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Sample records for vesical micturition pressure

  1. Effect of pelvic floor muscle contraction on vesical and rectal function with identification of puborectalis-rectovesical inhibitory reflex and levator-rectovesical excitatory reflex.

    Science.gov (United States)

    Shafik, A; El-Sibai, O

    2001-08-01

    The effects of pelvic floor muscle contraction on rectal and vesical function were studied in 19 healthy volunteers with the aim of shedding light on some of the hitherto vague aspects of the mechanisms involved in micturition and defecation and their disorders. Rectal and vesical pressures were recorded during puborectalis (PR) and levator ani (LA) muscle stimulation with the rectum or urinary bladder empty and full. Muscle stimulation was effected by needle EMG electrode. The pressure responses to stimulation of the PR and LA muscles were also recorded with these muscles and the rectum and urinary bladder individually anesthetized in 12 of the 19 subjects. The test was repeated using saline instead of xylocaine. PR and LA muscle stimulation produced no pressure response in the empty rectum or bladder. Upon rectal balloon distension with a mean of 156.6+/-34.2 ml of carbon dioxide the mean rectal pressure was 64.6+/-18.7 cm H2O, the subject felt the urge to evacuate and the balloon was expelled to the exterior. On PR muscle stimulation at rectal distension with the above volume, the subject did not feel the urge to evacuate, the rectal pressure was 8.2+/-1.6 cm H2O and the balloon was not expelled. Upon LA stimulation at the same volume, the urge persisted, the rectal pressure was higher and the balloon was expelled. Vesical filling with a mean of 378.2+/-23.6 ml of saline initiated the urge to urinate and elevated the vesical pressure. PR muscle stimulation at this volume aborted the urge and pressure elevation, while LA stimulation caused more elevation of the vesical pressure and spontaneous micturition. Bladder filling with a mean of 423.6+/-38.2 ml produced high vesical pressure and spontaneous urination, both of which were prevented by PR muscle stimulation but not by LA muscle stimulation. Stimulation of the PR and LA muscles during individual anesthetization of the rectum, bladder or PR and LA muscles resulted in no significant rectal or vesical pressure

  2. Micturition and the soul

    NARCIS (Netherlands)

    Holstege, G

    2005-01-01

    There is a close connection between micturition and emotion. Several species use micturition to signal important messages as territorial demarcation and sexual attraction. For this reason, micturition is coordinated not in the spinal cord but in the brainstem, where it is closely connected with the

  3. Congenital vesical diverticulum in a child

    OpenAIRE

    岩佐, 厚; 本城, 充; 中村, 正広; 松田, 稔; 児玉, 正道

    1988-01-01

    A case of congenital vesical diverticulum in childhood is reported and 28 other cases in children from the Japanese literature are reviewed. A 9-year-old boy presented with hematuria and two-phase micturition. Excretory urogram and voiding cystourethrogram showed a diverticulum of the bladder on the left side and left vesico-ureteral reflex. Diverticulectomy and left ureteroneocystostomy (by Paquin's method) were performed. Post-surgical recovery was very good. All 28 cases we reviewed were i...

  4. Micturition and the soul.

    Science.gov (United States)

    Holstege, Gert

    2005-12-05

    There is a close connection between micturition and emotion. Several species use micturition to signal important messages as territorial demarcation and sexual attraction. For this reason, micturition is coordinated not in the spinal cord but in the brainstem, where it is closely connected with the limbic system. In cat, bladder afferents terminate in a cell group in the lateral dorsal horn and lateral part of the intermediate zone. Neurons in this cell group project to supraspinal levels, not to the thalamus but to the central periaqueductal gray (PAG). Neurons in the lateral PAG, not receiving direct sacral cord afferents, project to the pontine micturition center (PMC). The PMC projects directly to the parasympathetic bladder motoneurons and to sacral GABA-ergic and glycinergic premotor interneurons that inhibit motoneurons in Onuf's nucleus innervating the external striated bladder sphincter. Thus, PMC stimulation causes bladder contraction and bladder sphincter relaxation, i.e., complete micturition. Other than the PAG, only the preoptic area and a cell group in the caudal hypothalamus project directly to the PMC. The ventromedial upper medullary tegmentum also sends projections to the PMC, but they are diffuse and also involve structures that adjoin the PMC. Neuroimaging studies in humans suggest that the systems controlling micturition in cat and human are very similar. It seems that the many structures in the brain that are known to influence micturition use the PAG as relay to the PMC. This basic organization has to be kept in mind in the fight against overactive bladder (OAB) and urge-incontinence. (c) 2005 Wiley-Liss, Inc.

  5. Effects of diuresis on micturition.

    Science.gov (United States)

    Levin, R M; Wein, A J; Eika, B; Tammela, T L; Longhurst, P A

    1995-01-01

    Micturition can be characterized experimentally by monitoring both the frequency and volume of micturition. Previous studies demonstrated that the functional capacity of the rat and rabbit bladder, as determined by cystometry, is approximately equal to the maximal single micturition volume as recorded over a 24 hour period. Studies in many laboratories have demonstrated that chronic increases in diuresis induce increases in micturition frequency and capacity, and an increase in bladder mass. The current study compares the temporal relationship among these parameters in three models of diuresis: streptozotocin-induced diabetes in rats, sucrose-induced diuresis in rats, and furosemide-induced diuresis in rabbits. In both sucrose diuresis in rats and furosemide diuresis in rabbits there were immediate increases in both the frequency and volume of micturition. The magnitude of the increases in micturition frequency and micturition volume paralleled the increase in the total volume of urine excreted. Bladder mass increased progressively over the time course of the study. Streptozotocin-induced diabetes resulted in a more gradual (but parallel) increase in micturition frequency and volume, and again a more gradual increase in bladder mass. These studies demonstrate that functional bladder capacity is increased immediately upon the initiation of diuresis with sucrose or furosemide, as is the frequency of micturition. This indicates that functional bladder capacity is probably under neuronal regulation and the change in capacity is not a function of the increased bladder mass which occurs at a later time period.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. Actions of tramadol on micturition in awake, freely moving rats

    Science.gov (United States)

    Pandita, Raj Kumar; Pehrson, Rikard; Christoph, Thomas; Friderichs, Elmar; Andersson, Karl-Erik

    2003-01-01

    (±)-Tramadol, a widely used analgesic, is a racemate stimulating opioid receptors and inhibiting reuptake of noradrenaline and serotonin, that is, pharmacological principles previously shown to influence rat micturition. We studied both (±)-tramadol and its enantiomers in conscious Sprague–Dawley rats undergoing continuous cystometry. The effects of these agents were compared to those of morphine (μ-opioid receptor agonist) and tested after pretreatment with naloxone (μ-opioid receptor antagonist). Cystometries were evaluated before and after intravenous (i.v.), intraperitoneal (i.p.) and intrathecal (i.t.) drug administrations. The most conspicuous effects of i.v. (±)-tramadol (0.1–10 mg kg−1) was an increase in threshold pressure and an increase in micturition volume. These effects were mimicked by (+)-tramadol (0.1–5 mg kg−1 i.v.), whereas (−)-tramadol (5 mg kg−1 i.v.) did not influence threshold pressure and micturition volume. The effects of (±)-tramadol 5 mg kg−1 on micturition volume were blocked by pretreatment with naloxone 0.3 mg kg−1. Morphine (0.3–10 mg kg−1 i.p.) increased threshold pressure but did not significantly increase micturition volume in doses not resulting in overflow incontinence. (±)-Tramadol 10 mg kg−1 increased urine production, an effect blocked by desmopressin 25 ng kg−1. (±)-Tramadol effectively inhibits micturition in conscious rats by stimulating μ-opioid receptors. A synergy between opioid receptor stimulation and monoamine reuptake inhibition may contribute to the micturition effects. PMID:12812997

  7. Disorders of micturition in small animal patients: clinical significance, etiologies, and management strategies.

    Science.gov (United States)

    Langfitt, Eric; Prittie, Jennifer E; Buriko, Yekaterina; Calabro, Janine M

    2017-03-01

    To review the physiology of micturition, the pathophysiology of micturition disorders, and current pharmacological agents used to treat these disorders. To discuss different urinary catheterization techniques, along with the risks of catheter-associated urinary tract infections attributed with these techniques. Many critically ill veterinary patients are at risk of developing a number of neurological and non neurological micturition-related disorders. Micturition disorders can be diagnosed based on physical examination findings, urinary voiding contrast studies, urethral pressure profiles, and diagnostic testing such as urinalysis and urine cultures. Therapy can be either pharmacological, involvement of urinary catheterization, surgical, or a combination of all the above. The goal of the treatment is to correct the underlying causes resulting in the micturition-related disorder, and if possible, allow the patient to regain their normal physiological micturition behavior. Depending on the underlying disease process and duration of the micturition disorder, the prognosis can be variable. In many instances, near-normal or normal function can return, but in severe cases, the patient may not regain its normal, appropriate micturition response. © Veterinary Emergency and Critical Care Society 2017.

  8. Brain activation during micturition in women

    NARCIS (Netherlands)

    Blok, Bertil F.M.; Sturms, Leontien M.; Holstege, Gert

    1998-01-01

    Experiments in the cat have led to a concept of how the CNS controls micturition. In a previous study this concept was tested in a PET study in male volunteers, It was demonstrated that specific brainstem and forebrain areas are activated during micturition, It was unfortunate that this study did

  9. Micturitional disturbance in Wernicke's encephalopathy.

    Science.gov (United States)

    Sakakibara, R; Hattori, T; Yasuda, K; Yamanishi, T; Tojo, M; Mori, M

    1997-01-01

    A 24-year-old pregnant woman started to have hyperemesis gravidarum 6 weeks before admission. Four weeks later she had vertigo, diplopia, staggering gait, mild dyspnea, dysphagia, and incontinence of urine. On admission she presented with ophthalmoplegia, ptosis, ataxia, decreased tendon reflex, and memory disturbance. Brain magnetic resonance imaging revealed abnormal intensities in medial thalamic-hypothalamic regions and the periaqueductal area, and she was diagnosed with Wernicke's encephalopathy. Urodynamic studies revealed decreased bladder volume and detrusor hyperreflexia. Six weeks after the administration of 100 mg/day of thiamine, urge incontinence gradually recovered, together with neurological signs. Lesions of the medial thalamic-hypothalamic area and the periaqueductal gray matter seemed to be mainly responsible for micturitional disturbance in our patient with Wernicke's encephalopathy.

  10. An Unusual Vesical Calculus

    Directory of Open Access Journals (Sweden)

    Umar Amin

    2009-01-01

    Full Text Available

    We report a 52 year old patient presenting with a bladder stone formed over a migrated intrauterine device (copper -T. Her history was pertinent for intrauterine contraceptive (IUCD device placement 10 years back. Investigations included plain ultrasound of abdomen, X-ray of abdomen, urinalysis, and urine culture. Ultrasound and plain X-ray of the pelvis confirmed a bladder stone formed over a migrated copper-T intrauterine device. The device was removed through suprapubic cystolithotomy. Of all the reported cases of vesical stone formation over a migrated IUCD, this case is unique as the patient was an elderly - 52 year old - female. All previously reported cases are of younger age.

  11. The emotional motor system and micturition control.

    Science.gov (United States)

    Holstege, Gert

    2010-01-01

    Micturition is, similar to all other movements of the body, the result of activation of the motor system in the central nervous system. This review explains how the brain and brainstem control micturition. The basic reflex system begins with a distinct cell group called Gert's Nucleus (GN) in the sacral cord. GN receives information about bladder contents via A-delta fibers from the bladder and bladder sphincter and relays this information to the central part of the midbrain periaqueductal gray (PAG), but not to the thalamus. The PAG, in turn, in case of substantial bladder filling, excites the pontine micturition center (PMC), which cell group, via its long descending pathways to the sacral cord, induces micturition. Higher brain regions in prefrontal cortex and limbic system, by means of its projections to the PAG are able to interrupt this basic reflex system. It allows the individual to postpone micturition until time and place are appropriate. Lesions in the pathways from prefrontal cortex and limbic system to the PAG probably cause urge-incontinence in the elderly.

  12. La sifilis latente vesical

    Directory of Open Access Journals (Sweden)

    Pablo Gómez Martínez

    1948-01-01

    Full Text Available Con este título me propongo presentar los conocimientos y experiencias sacados de la investigación cistoscópica llevada a cabo sobre un total de 400 enfermos examinados en el Departamento de Endoscopia del Hospital de la Samaritana, durante el año de 1946. El autor, describió y publicó por primera vez en Colombia en el año de 1944, 2 casos de sífilis vesical que se presentaron sobre un total de 3.323 pacientes sifilíticos examinados durante los años de 1939, 1940 Y parte de 1941, o sea una incidencia del 1/2 por mil. El porcentaje encontrado sobre enfermos que se quejaban de su aparato urinario fue de 0,30 (1. Entre la numerosa literatura consultada, figuran dos artículos de autores brasileros que nos llamaron mucho la atención, por la frecuencia con que ellos encontraron lesiones vesicales atribuibles a la sífilis y que denominaron "Sífilis latente de la Vejiga". Como sus idea no estaban de acuerdo con los hechos observados por nosotros, ni con la experiencia adquirida en varios años de continuos exámenes cistoscópicos, nos dimos al trabajo de investigar de una manera minuciosa, serena e imparcial, la presencia o ausencia de las lesiones vesicales descritas, lo mismo que la morfología que pudieran tener en nuestro medio.

  13. Fainting during Urination (Micturition Syncope): What Causes It?

    Science.gov (United States)

    ... causes this, and what can he do about it? Answers from Phillip A. Low, M.D. Micturition ( ... of micturition syncope isn't fully understood. But it may be related to opening (vasodilation) of the ...

  14. Serotonin and noradrenaline reuptake inhibitors improve micturition control in mice.

    Directory of Open Access Journals (Sweden)

    Marco Redaelli

    Full Text Available Poor micturition control may cause profound distress, because proper voiding is mandatory for an active social life. Micturition results from the subtle interplay of central and peripheral components. It involves the coordination of autonomic and neuromuscular activity at the brainstem level, under the executive control of the prefrontal cortex. We tested the hypothesis that administration of molecules acting as reuptake inhibitors of serotonin, noradrenaline or both may exert a strong effect on the control of urine release, in a mouse model of overactive bladder. Mice were injected with cyclophosphamide (40 mg/kg, to increase micturition acts. Mice were then given one of four molecules: the serotonin reuptake inhibitor imipramine, its metabolite desipramine that acts on noradrenaline reuptake, the serotonin and noradrenaline reuptake inhibitor duloxetine or its active metabolite 4-hydroxy-duloxetine. Cyclophosphamide increased urine release without inducing overt toxicity or inflammation, except for increase in urothelium thickness. All the antidepressants were able to decrease the cyclophosphamide effects, as apparent from longer latency to the first micturition act, decreased number of urine spots and volume of released urine. These results suggest that serotonin and noradrenaline reuptake inhibitors exert a strong and effective modulatory effect on the control of urine release and prompt to additional studies on their central effects on brain areas involved in the social and behavioral control of micturition.

  15. A PET study on brain control of micturition in humans

    NARCIS (Netherlands)

    Blok, BFM; Willemsen, ATM; Holstege, G

    Although the brain plays a crucial role in the control of micturition, little is known about the structures involved. Identification of these areas is important because their dysfunction is thought to cause urge incontinence, a major problem in the elderly. In the cat, three areas in the brainstem

  16. Vesical paragonimiasis diagnosed by histopathology: a case report.

    Science.gov (United States)

    Yue, Xuan; Wei, Xin; Zhu, Yuchun; Han, Ping; Li, Xiang; Wei, Qiang; Liu, Liangren

    2014-01-01

    Vesical paragonimiasis is an extremely rare form of ectopic infestation caused by Paragonimus spp. We reported a case of vesical paragonimiasis associated with urinary symptoms but without history of respiratory symptoms or cercarial dermatitis. The diagnosis was made by histopathological examination of the surgical specimens of the vesical masses. Identification of the species by morphometric analysis of the fluke body sections indicated that the vesical lesion was caused by Paragonimus. Postsurgical medication with the antiparasitic drug praziquantel was applied regularly, and the patient experienced a stable recovery. 2013 S. Karger AG, Basel.

  17. Functional magnetic resonance imaging during urodynamic testing identifies brain structures initiating micturition.

    Science.gov (United States)

    Shy, Michael; Fung, Steve; Boone, Timothy B; Karmonik, Christof; Fletcher, Sophie G; Khavari, Rose

    2014-10-01

    Normal voiding in neurologically intact patients is triggered by the release of tonic inhibition from suprapontine centers, allowing the pontine micturition center to trigger the voiding reflex. Supraspinal mechanisms of voluntary voiding in humans are just beginning to be described via functional neuroimaging. We further elucidated brain activity processes during voiding using functional magnetic resonance imaging in normal females to gain better understanding of normal voiding as well as changes that may occur in voiding dysfunction. We screened 13 healthy premenopausal female volunteers using baseline clinic urodynamics to document normal voiding parameters. We then recorded brain activity via functional magnetic resonance imaging and simultaneous urodynamics, including the pressure flow voiding phase. After motion correction of functional magnetic resonance images we performed activation and connectivity analyses in 10 subjects. Group analysis revealed consistent activation areas, including regions for motor control (cerebellum, thalamus, caudate, lentiform nucleus, red nucleus, supplementary motor area and post-central gyrus), emotion (anterior/posterior cingulate gyrus and insula), executive function (left superior frontal gyrus) and a focal region in the pons. Connectivity analysis demonstrated strong interconnectivity of the pontine micturition center with many short-range and long-range cortical clusters. Our study is one of the first reports of brain activation centers associated with micturition initiation in normal healthy females. Results show activation of a brain network consisting of regions for motor control, executive function and emotion processing. Further studies are planned to create and validate a model of brain activity during normal voiding in women. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  18. URETERO-VESICAL ANASTOMOTIC COMPLICATIONS AFTER KIDNEY TRANSPLANTATION

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    S. V. Shkodkin

    2011-01-01

    Full Text Available This article presents statistical analysis of vesico-ureteric reflux and uretero-vesical obstruction incidence after kidney transplantation depending on technique mode. In this item prevalence of chronic pyelonephritis and spe- cies of causative agent data are analyzed. The necessity of effective methods to accomplish the uretero-vesical anastomosis is suggested. 

  19. Study of the response of the penile corporal tissue and cavernosus muscles to micturition

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    El Sibai Olfat

    2008-03-01

    Full Text Available Abstract Background The reaction of the corpora cavernosa (CC, the corpus spongiosum (CS, the bulbocavernosus (BCM and ischiocavernosus (ICM muscles to passage of urine through the urethra during micturition is not known. We investigated the hypothesis that the passage of urine through the urethra stimulates the corporal tissue and cavernosus muscles. Methods In 30 healthy men (mean age 42.8 ± 11.7 years, the electromyographic activity (EMG of the CC, CS, BCM, and ICM were recorded before and during micturition, and on interruption of and straining during micturition. These tests were repeated after individual anesthetization of urethra, corporal tissue, and cavernosus muscles. Results During micturition, the slow wave variables (frequency, amplitude, conduction velocity of the CC and CS decreased while the motor unit action potentials of the BCM and ICM increased; these EMG changes were mild and returned to the basal values on interruption or termination of micturition. Micturition after individual anesthetization of urethra, corporal tissue and cavernosal muscles did not effect significant EMG changes in these structures, while saline administration produced changes similar to those occurring before saline administration. Conclusion The decrease of sinusoidal and increase of cavernosus muscles' EMG activity during micturition apparently denotes sinusoidal relaxation and cavernosus muscles contraction. Sinusoidal muscle relaxation and cavernosus muscles contraction upon micturition are suggested to be mediated through a 'urethro-corporocavernosal reflex'. These sinusoidal and cavernosus muscle changes appear to produce a mild degree of penile tumescence and stretch which might assist in urinary flow during micturition.

  20. Vesical hemangioma in patient with Klippel-Trenaunay-Weber syndrome

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    Favorito Luciano A.

    2003-01-01

    Full Text Available Klippel-Trenaunay-Weber syndrome is characterized by cutaneous hemangiomas, varicosity and bony hypertrophy of extremities. Urinary tract hemangiomas may occur in 3 to 6% of these patients. This work intends to report a case of a patient with a huge vesical hemangioma, who presented this syndrome. A 5 year-old boy with Klippel syndrome sought our services due to 3 episodes of gross hematuria in the past 30 days. Excretory urography and computerized tomography were performed, indicating the presence of a swelling in vesical dome. An exploratory cystotomy was conducted and the dark colored mass in vesical dome was excised by partial cystectomy. The histopathologic finding confirmed that it was a vesical hemangioma. Though rare, urinary tract hemangiomas must always be considered in patients with Klippel-Trenaunay syndrome.

  1. The central nervous system control of micturition in cats and humans

    NARCIS (Netherlands)

    Blok, BFM; Holstege, G

    Recent findings concerning the central control of micturition in cats are compared to findings obtained from dynamic imaging studies in humans. In the cat, three areas in the brainstem and diencephalon are specifically implicated in the control of micturition: (1) Barrington's nucleus or the pontine

  2. MANEJO LAPAROSCÓPICO DE DISPOSITIVO INTRAUTERINO INCRUSTADO EN PARED VESICAL CON LITIASIS VESICAL SECUNDARIA

    OpenAIRE

    Zarhi T,Jaime; Vacca G,Fernando; Sanhueza R,Pablo; Díaz M,Jorge; RIFFO R,RODRIGO

    2009-01-01

    Se presenta el caso clínico de la migración intravesical de dispositivo intrauterino con litiasis vesical secundaria. El diagnóstico se realizó 20 años después de la inserción del dispositivo, por la aparición de síntomas urinarios bajos a repetición y hematuria. La ultrasonografía y la radiografía de pelvis son herramientas diagnósticas relevantes en la sospecha inicial de esta patología, que debe siempre completarse con tomografía pélvica y cistoscopia.

  3. Implante uretero-vesical em ratos

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    Tucci Jr. Silvio

    2000-01-01

    Full Text Available Apresentar os resultados obtidos com técnica de implante ureterovesical em ratos após obstrução ureteral ipsilateral. Treze ratos foram submetidos à obstrução ureteral distal à direita e, após uma semana, realizou-se o implante desse ureter na bexiga seguido da nefrectomia contralateral. No período de observação de 4 semanas foram estudados os níveis séricos semanais de uréia e creatinina e, na quarta semana, foi realizada cistografia para pesquisa de refluxo vésico-ureteral. Nove animais sobreviveram ao período de obstrução ureteral. Observou-se aumento significativo dos valores de uréia e creatinina sérica no segundo dia pós-operatório, que regrediram para níveis semelhantes aos basais já na terceira semana de seguimento. Não foi observado refluxo vésico-ureteral à cistografia. Após o sacrifício, a avaliação da junção uretero-vesical não mostrava sinais de obstrução, havendo regressão da hidronefrose presente antes do implante ureteral. A técnica de reimplante ureteral utilizada é eficaz em proporcionar adequada drenagem do trato urinário, evitando refluxovésico-ureteral, sendo adequada para ser utilizada no estudo da recuperação da função renal após período de obstrução ureteral.

  4. Activation and inhibition of the micturition reflex by penile afferents in the cat

    National Research Council Canada - National Science Library

    John P. Woock; Paul B. Yoo; Warren M. Grill

    2008-01-01

    .... We quantified the effects on the micturition reflex of sensory inputs from genital afferents traveling in the penile component of the somatic pudendal nerve by electrical stimulation of the dorsal nerve of the penis (DNP) in α...

  5. vesical gossypiboma mimicking calculus: a report of two

    African Journals Online (AJOL)

    abdominal X-ray revealed calcified intra-vesical masses that were removed by open suprapubic cystotomy. Small gauze ... and use of radio-opaque markers have not eliminated the ... lead to two types of foreign body reactions: an exudative ...

  6. Atypical presentation of an enormous vesical calculus: A case report

    African Journals Online (AJOL)

    A.T. Lawal

    2016-05-20

    May 20, 2016 ... are detected on time. © 2016 Pan African Urological Surgeons' Association. Production and hosting by Elsevier B.V. All rights reserved. Introduction. Urinary bladder stones (vesical calculi) are generally uncommon, however, they represent the most common manifestation of lower urinary tract lithiasis [1].

  7. Giant vesical calculi: experience with management of two Nigerians ...

    African Journals Online (AJOL)

    Two cases of Giant Vesical Calculi were encountered in a semi-urban health facility (Nakowa Hospital, Yauri, Nigeria). careful clinical evaluation and investigation is important in the work up of the patients. surgical technique and accurate diagnosis are essential in their treatment. Nigerian Journal of Surgical Research Vol.

  8. Bladder Calculus Following an Unusual Vesical Foreign Body ...

    African Journals Online (AJOL)

    Bladder calculus following vesical foreign bodies is uncommon. The usual presentation is presence of lower urinary symptoms. Most of these foreign bodies are either left inadvertently after open bladder operations or migrate from adjacent structures. This is a case report of an unusual self inserted foreign body in a female ...

  9. Peri-Vesical Fat Interposition Flap Reinforcement in High Vesico ...

    African Journals Online (AJOL)

    Background and Aim: The urinary bladder becomes small, contracted and is associated with excess pelvic fat in long standing cases of vesico-vaginal fistulas (VVFs). The aim of this new technique was to use this excess pelvic fat for harvesting an interposition flap. Materials and Methods: An interposition flap of peri-vesical ...

  10. Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity.

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    Oki, Tomomi; Suzuki, Mayumi; Nishioka, Yasuhiko; Yasuda, Akio; Umegaki, Keizo; Yamada, Shizuo

    2005-04-01

    We examined the effects of saw palmetto extract (SPE) on the rat micturition reflex and on autonomic receptors in the lower urinary tract. The effect of SPE was examined on cystometrograms of anesthetized rats induced by intravesical infusion of saline or 0.1% acetic acid. SHR/NDmc-cp (cp/cp) rats received repeat oral administration of SPE and nighttime urodynamic function was determined. The autonomic receptor binding activity of SPE in the rat bladder and prostate was examined by radioligand binding assay. Intraduodenal administration of SPE (60 mg/kg) in anesthetized rat cystometry caused a significant increase in the micturition interval, micturition volume and bladder capacity during intravesical saline infusion. Also, similar administration of SPE at doses of 12 and 20 mg/kg significantly reversed the shortened micturition interval as well as the decreased micturition volume and bladder capacity due to 0.1% acetic acid infusion in a dose dependent manner. In conscious SHR/NDmc-cp (cp/cp) rats repeat oral administration of SPE (6 mg/kg daily) constantly increased the micturition interval and concomitantly decreased voiding frequency. SPE inhibited specific binding of [H]NMS ([N-methyl-H]scopolamine methyl chloride) (bladder) and [H]prazosin (prostate) with IC50 values of 46.1 and 183 microg/ml, respectively. SPE significantly alleviates urodynamic symptoms in hyperactive rat bladders by increasing bladder capacity and subsequently prolonging the micturition interval. Our data may support the clinical efficacy of SPE for the treatment of lower urinary tract symptoms.

  11. Vesical fistulae--an experience from a developing country.

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    Raut V

    1993-01-01

    Full Text Available This study analyses patients with vesical fistulae presenting at a teaching, referral hospital over the last ten years. There were 62 cases of vesical fistulae of which 60 were obstetric in origin (44 home and 16 hospital deliveries and 2 were following gynaecological surgery. Of the hospital deliveries which culminated in fistula formation, 8 were vaginal and 7 forceps deliveries. In one patient, lower segment caesarean section was carried out. After a thorough urological work-up, patients were subjected to standard technique of layered closure (61 by vaginal approach and one by abdominal. Repair was successful in 53 (87.09% patients. Of the 9 failures, 4 were repeat repairs.

  12. An exploration of the control of micturition using a novel in situ arterially perfused rat preparation

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    Prajni eSadananda

    2011-05-01

    Full Text Available Our goal was to develop and refine a decerebrate arterially perfused rat preparation (DAPR that allows the complete bladder filling and voiding cycle to be investigated without some of the restrictions inherent with in vivo experimentation (e.g. ease and speed of set up (30mins, control over the extracellular milieu and free of anaesthetic agents. Both spontaneous (naturalistic bladder filling from ureters and evoked (in response to intravesical infusion voids were routinely and reproducibly observed which had similar pressure characteristics. The DAPR allows the simultaneous measurement of bladder intra-luminal pressure, external urinary sphincter electromyogram (EUS–EMG, pelvic afferent nerve activity, pudendal motor activity and permits excellent visualisation of the entire lower urinary tract, during typical rat filling and voiding responses. The voiding responses were modulated or eliminated by interventions at a number of levels including at the afferent terminal fields (intravesical capsaicin sensitisation-desensitisation, autonomic (ganglion blockade with hexamethonium and somatic motor (vecuronium block of the EUS outflow and required intact brainstem/hindbrain-spinal coordination (as demonstrated by sequential hindbrain transections. Both innocuous (eg perineal stimulation and noxious (tail/paw pinch somatic stimuli elicited an increase in EUS-EMG indicating intact sensory feedback loops. Spontaneous non-micturition contractions were observed between fluid infusions at a frequency and amplitude of 1.4±0.9 per minute and 1.4±0.3mmHg, respectively, and their amplitude increased when autonomic control was compromised. In conclusion, the DAPR is a tractable and useful model for the study of neural bladder control showing intact afferent signaling, spinal and hindbrain co-ordination and efferent control over the lower urinary tract end organs and can be extended to study bladder pathologies and trial novel treatments.

  13. Effect of S-methyl-l-thiocitrulline dihydrochloride on rat micturition reflex

    Directory of Open Access Journals (Sweden)

    Jeová Nina Rocha

    Full Text Available ABSTRACT Objective: To evaluate the effect of neuronal nitric oxide synthase on the striated urethral sphincter and the urinary bladder. Materials and Methods: A coaxial catheter was implanted in the proximal urethra and another one in the bladder of female rats, which were anesthetized with subcutaneous injection of urethane. The urethral pressure with saline continuous infusion and bladder isovolumetric pressure were simultaneously recorded. Two groups of rats were formed. In group I, an intrathecal catheter was implanted on the day of the experiment at the L6-S1 level of the spinal cord; in group II, an intracerebroventricular cannula was placed 5-6 days before the experiment. Results: It was verified that the group treated with S-methyl-L-thio-citrulline, via intrathecal pathway, showed complete or partial inhibition of the urethral sphincter relaxation and total inhibition of the micturition reflexes. The urethral sphincter and the detrusor functions were recovered after L-Arginine administration. When S-methyl-L-thio-citrulline was administered via intracerebroventricular injection, there was a significant increase of urethral sphincter tonus while preserving the sphincter relaxation and the detrusor contractions, at similar levels as before the use of the drugs. Nevertheless there was normalization of the urethral tonus when L-Arginine was applied. Conclusions: The results indicate that, in female rats anaesthetized with urethane, the nNOS inhibitor administrated through the intrathecal route inhibits urethral sphincter relaxation, while intracerebroventricular injection increases the sphincter tonus, without changing bladder function. These changes were reverted by L-Arginine administration. These findings suggest that the urethral sphincter and detrusor muscle function is modulated by nitric oxide.

  14. Vesical schistosomiasis in north eastern part of Imo state, Nigeria ...

    African Journals Online (AJOL)

    More females (30.8%) than males (24.1%) were infected in all the age groups and high rate of hematuria (56.6%) was observed among the infected subjects. Prevalence of vesical schistosomiasis was significantly higher (77.9%) among those in the age group 11-20 years than those of 41-50 years (p<0.05). The intensity of ...

  15. Superior vesical fissure concealed by giant omphalocele: A case report

    OpenAIRE

    Hayek, Danial; Massanyi, Eric; Mancuso, Melissa; Krepkovich, Katherine; Garrison, Aaron

    2016-01-01

    Omphalocele is an abdominal wall defect characterized by exteriorization of abdominal viscera that is covered by a membrane. Omphalocele has a well-known association with chromosome abnormalities. Here we present a case of a superior vesical fissure (SVF) initially disguised as a giant omphalocele in a newborn with trisomy 18. We also show unique prenatal imaging and discuss the importance and limitations of prenatal genetic testing.

  16. Superior vesical fissure concealed by giant omphalocele: A case report

    Directory of Open Access Journals (Sweden)

    Danial Hayek

    2016-11-01

    Full Text Available Omphalocele is an abdominal wall defect characterized by exteriorization of abdominal viscera that is covered by a membrane. Omphalocele has a well-known association with chromosome abnormalities. Here we present a case of a superior vesical fissure (SVF initially disguised as a giant omphalocele in a newborn with trisomy 18. We also show unique prenatal imaging and discuss the importance and limitations of prenatal genetic testing.

  17. Electrical nerve stimulation to promote micturition in spinal cord injury patients: A review of current attempts.

    Science.gov (United States)

    Ren, Jian; Chew, Daniel J; Biers, Suzanne; Thiruchelvam, Nikesh

    2016-03-01

    In this review, we focus on the current attempts of electrical nerve stimulation for micturition in spinal cord injury (SCI) patients. A literature search was performed through PubMed using "spinal cord injury," "electrical nerve stimulation AND bladder," "sacral anterior root stimulation/stimulator" and "Brindley stimulator" from January 1975 to January 2014. Twenty studies were selected for this review. Electrical nerve stimulation is a clinical option for promoting micturition in SCI patients. Well-designed, randomized and controlled studies are essential for further investigation. © 2015 Wiley Periodicals, Inc.

  18. Balloon-occluded percutaneous transheptic obliteration of isolated vesical varices causing gross hematuria

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Dong Hoon; Kim, Dong Hyun; Kim, Min Seok; Kim, Chul Sung [Department of Urology, College of Medicine, Chosun University, Gwangju (Korea, Republic of)

    2013-01-15

    Gross hematuria secondary to vesical varices is an unusual presentation. We report such a case recurrent gross hematuria in a male patient who had a history of bladder substitution with ileal segments that had been treated by balloon-occluded percutaneous transhepatic obliteration of vesical varices.

  19. Displacement and recovery of the vesical neck position during pregnancy and after childbirth

    NARCIS (Netherlands)

    Wijma, Jacobus; Potters, AInemarie E. Weis; van der Mark, Thomas W.; Tinga, Dick J.; Aarnoudse, Jan G.

    2007-01-01

    Aims: (i) To describe the displacement and recovery of the vesical neck position during pregnancy and after childbirth and (ii) to discriminate between compliance of the vesical neck supporting structures with and without pelvic floor contraction. Methods: We focussed on the biomechanical properties

  20. Presentation of an ingested foreign body as a vesical calculus: a ...

    African Journals Online (AJOL)

    Vesical calculus is a common entity in children of developing countries. Foreign body ingestion is a common occurrence in the pediatric population. An ingested foreign body eroding into the urinary bladder and leading to the formation of a vesical calculus is an extremely rare condition. We encountered a 14-year-old girl ...

  1. Giant vesical calculus in a ten year-old boy - a case report | Saleh ...

    African Journals Online (AJOL)

    This is a case of longstanding urinary tract symptoms in a 10 year old boy in which multi-modality imaging revealed multiple radio-opaque calculi including a giant vesical calculus. He had surgical removal of the stone with no post-op complications. Keywords: Giant, Vesical Calculus, 10 years old ...

  2. Activation and inhibition of the micturition reflex by penile afferents in the cat.

    Science.gov (United States)

    Woock, John P; Yoo, Paul B; Grill, Warren M

    2008-06-01

    Coordination of the urinary bladder and the external urethral sphincter is controlled by descending projections from the pons and is also subject to modulation by segmental afferents. We quantified the effects on the micturition reflex of sensory inputs from genital afferents traveling in the penile component of the somatic pudendal nerve by electrical stimulation of the dorsal nerve of the penis (DNP) in alpha-chloralose anesthetized male cats. Depending on the frequency of stimulation (range, 1-40 Hz), activation of penile afferents either inhibited contractions of the bladder and promoted urine storage or activated the bladder and produced micturition. Stimulation of the DNP at 5-10 Hz inhibited distension-evoked contractions and increased the maximum bladder capacity before incontinence. Conversely, stimulation at 33 and 40 Hz augmented distension-evoked contractions. When the bladder was filled above a threshold volume (70% of the volume necessary for distension-evoked contractions), stimulation at 20-40 Hz activated de novo the micturition reflex and elicited detrusor contractions that increased voiding efficiency compared with distension-evoked voiding. Electrical stimulation of the DNP with a cuff electrode or percutaneous wire electrode produced similar results. The ability to evoke detrusor contractions by activation of the DNP was preserved following acute spinal cord transection. These results demonstrate a clear role of genital afferents in modulating the micturition reflex and suggest the DNP as a potential target for functional restoration of bladder control using electrical stimulation.

  3. Effect of chemical stimulation of the medial frontal lobe on the micturition reflex in rats.

    Science.gov (United States)

    Nishijima, Saori; Sugaya, Kimio; Kadekawa, Katsumi; Ashitomi, Katsuhiro; Yamamoto, Hideyuki

    2012-03-01

    We assessed the influence of the medial frontal lobe on micturition after chemical stimulation. We also examined the relation between the medial frontal lobe and the rostral pontine reticular formation, which has a strong inhibitory effect on micturition. A total of 35 female rats underwent continuous cystometry. Bladder activity changes were examined after physiological saline, glutamate, the glutamate receptor antagonist MK-801, noradrenaline or the adrenergic α-1 receptor antagonist naftopidil was injected in the medial frontal lobe. When glutamate was injected in the medial frontal lobe, MK-801 was also injected in the rostral pontine reticular formation. Glutamate injection in the medial frontal lobe prolonged the interval between bladder contractions while injection of the glutamate antagonist MK-801 shortened the interval. Glutamate injection in the medial frontal lobe just after MK-801 injection in the ipsilateral rostral pontine reticular formation also prolonged the interval between bladder contractions. However, after prior injection of MK-801 in the bilateral rostral pontine reticular formation glutamate injection in the medial frontal lobe did not influence cystometric parameters. Noradrenaline injection in the medial frontal lobe shortened the interval between bladder contractions while injection of its antagonist naftopidil prolonged the interval. Medial frontal lobe neurons excited by glutamate inhibited the micturition reflex via activation of the rostral pontine reticular formation by glutamatergic projection while medial frontal lobe neurons excited by noradrenaline facilitated the micturition reflex. Thus, the medial frontal lobe may be an important integration center for the initiation of micturition and urine storage mechanisms. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  4. Innervation of reconstructed bladder above the level of spinal cord injury for inducing micturition by contractions of the abdomen-to-bladder reflex arc.

    Science.gov (United States)

    Lin, Haodong; Hou, Chunlin; Chen, Aimin; Xu, Zhen

    2010-05-01

    To establish an artificial bladder reflex arc in dogs via an abdominal reflex pathway above the level of spinal cord injury to reinnervate the neurogenic bladder and restore controllable micturition. Ten beagles were used in the experiment. We anastomosed the proximal end of the right T12 ventral root and distal end of the right S2 ventral root by performing autogenous nerve grafting to build an abdomen-to-bladder reflex, whereas the right T12 dorsal root was kept intact. The early function of the reflex arc was evaluated by performing electrophysiological studies as well as by the measurement of intravesicular pressure and histological examination. Single focal stimulation of the right T12 intercostal nerves elicited evoked action potentials at the right vesicular plexus before and after horizontal spinal cord transaction between the L4 and S3 levels. Bladder contraction was successfully initiated by trains of stimuli targeting the right T12 intercostal nerves. The bladder pressures and amplitude of the complex action potentials at the bladder smooth muscles were unchanged after paraplegia was induced; they were comparable to those of the control. Prominent axonal sprouting was observed in the distal part of the nerve graft. Our data showed the effectiveness of bladder innervation above the level of spinal cord injury in inducing micturition by abdomen-to-bladder reflex contractions and, therefore, might provide a new clinical approach for restoring bladder function in individuals with paraplegia.

  5. Inhibitory effect of the nucleus reticularis pontis oralis on the pontine micturition center and pontine urine storage center in decerebrate cats.

    Science.gov (United States)

    Sugaya, Kimio; Nishijima, Saori; Miyazato, Minoru; Oda, Masami; Ogawa, Yoshihide

    2006-10-01

    The influence of the nucleus reticularis pontis oralis (PoO) on the pontine micturition center (PMC) and pontine urine storage center (PUSC) was examined in decerebrate cats by electrical and chemical stimulations of the PMC, PUSC or PoO. Microinjection of carbachol into the rostral and dorsolateral part of the PoO rapidly inhibited reflex micturition and external urethral sphincter (EUS) activity. After confirming the inhibition of reflex micturition and EUS activity by microinjection of carbachol into the PoO, intravenous injection of atropine sulfate or its microinjection into the PoO recovered both reflex micturition and EUS activity. Microinjection of carbachol into the PMC evoked micturition and then inhibited reflex micturition, but intravenous injection of atropine or its microinjection into the PoO recovered reflex micturition. After confi rming the inhibition of reflex micturition and EUS activity by microinjection of carbachol into the PoO, electrical stimulation of the PUSC enhanced EUS activity, but electrical stimulation of the PMC failed to evoke micturition. However, electrical stimulation of the PMC evoked micturition after microinjection of atropine into the PoO. These results suggest that the PoO strongly inhibits the PMC and less strongly inhibits the PUSC. Therefore, the PoO seems to be the pontine micturition inhibitory area.

  6. Primary Vesical Actinomycosis in a 23-Year-Old Man

    Directory of Open Access Journals (Sweden)

    Tevfik Ziypak

    2014-01-01

    Full Text Available Introduction. Actinomycosis can affect any organ of the body, although cutaneous fistulas are common in actinomycotic infections, and other organs such as the bladder are only rarely involved. Case Presentation. Herein we report and discuss a young male patient with primary vesical actinomycosis. A 23-year-old man was hospitalized complaining of intermittent gross hematuria over a 6-month duration. The patient underwent a cystoscopic examination under general anesthesia; an edematous, hyperemic, wide-based mass, which protruded from the dome of the bladder, was seen and incompletely resected. The histopathological examination of the material showed Actinomyces organisms surrounded by inflammation and a photomicrograph showed the microorganism. After confirmation of bladder actinomycosis, the patient received penicillin. A CT scan of the abdomen and pelvis showed no evidence of the mass at the postoperative 6th month. Cystoscopic examination showed complete healing of the transurethral resection area at the dome of the bladder. Conclusion. In conclusion, we believe that the gold standard treatment for vesical actinomycosis should include the combination of a transurethral resection of the mass and long-term penicillin treatment.

  7. Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats.

    Science.gov (United States)

    Stone, E; Coote, J H; Lovick, T A

    2015-05-01

    To understand how deep brain stimulation of the midbrain influences control of the urinary bladder. In urethane-anaesthetized male rats, saline was infused continuously into the bladder to evoke cycles of filling and voiding. The effect of electrical (0.1-2.0 ms pulses, 5-180 Hz, 0.5-2.5 V) compared to chemical stimulation (microinjection of D,L-homocysteic acid, 50 nL 0.1 M solution) at the same midbrain sites was tested. Electrical stimulation of the periaqueductal grey matter and surrounding midbrain disrupted normal coordinated voiding activity in detrusor and sphincters muscles and suppressed urine output. The effect occurred within seconds was reversible and not secondary to cardiorespiratory changes. Bladder compliance remained unchanged. Chemical stimulation over the same area using microinjection of D,L-homocysteic acid (DLH) to preferentially activate somatodendritic receptors decreased the frequency of micturition but did not disrupt the coordinated pattern of voiding. In contrast, chemical stimulation within the caudal ventrolateral periaqueductal grey, in the area where critical synapses in the micturition reflex pathway are located, increased the frequency of micturition. Electrical deep brain stimulation within the midbrain can inhibit reflex micturition. We suggest that the applied stimulus entrained activity in the neural circuitry locally, thereby imposing an unphysiological pattern of activity. In a way similar to the use of electrical signals to 'jam' radio transmission, this may prevent a synchronized pattern of efferent activity being transmitted to the spinal outflows to orchestrate a coordinated voiding response. Further experiments to record neuronal firing in the midbrain during the deep brain stimulation will be necessary to test this hypothesis. © 2015 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

  8. Activation and inhibition of the micturition reflex by penile afferents in the cat

    OpenAIRE

    Woock, John P; Yoo, Paul B.; Grill, Warren M.

    2008-01-01

    Coordination of the urinary bladder and the external urethral sphincter (EUS) is controlled by descending projections from the pons, and is also subject to modulation by segmental afferents. We quantified the effects on the micturition reflex of sensory inputs from genital afferents, traveling in the penile component of the somatic pudendal nerve, by electrical stimulation of the dorsal nerve of the penis (DNP) in α-chloralose anesthetized male cats. Depending on the frequency of stimulation ...

  9. Excitability changes in sacral afferents innervating the urethra, perineum and hindlimb skin of the cat during micturition

    Science.gov (United States)

    Buss, R R; Shefchyk, S J

    1999-01-01

    Excitability changes in afferents innervating the urethra, perineum and hindlimb were measured in decerebrated cats during micturition and in response to stimulation of lumbosacral afferents. Increases in excitability were interpreted as primary afferent depolarization (PAD) and decreases as primary afferent hyperpolarization.Excitability increases were observed in 11 of 19 urethral pudendal afferents during micturition. Four of these 11 afferents showed an excitability increase during voiding. Seven of these showed a biphasic change with a decrease in excitability when sphincter activity resumed at the end of the void. Three of 19 afferents showed an excitability decrease during micturition and no change was detected in five afferents.During micturition, the peak amplitude of urethral afferent-evoked excitatory postsynaptic potentials in seven of eight sphincter motoneurones was diminished to a mean of 36% of control values.Eighty per cent of hindlimb cutaneous afferents and 50% of dorsal penile/clitoral and superficial perineal nerve afferents in the sacral cord showed increased excitability during voiding. No excitability increases were measured in 13 hindlimb cutaneous fibres examined in the lumbar segments.PAD was observed in sacral urethral, perineal and hindlimb cutaneous afferents in response to electrical stimulation of other perineal, urethral, hindlimb cutaneous and group II muscle afferents.It is concluded that control of transmission from urethral afferents by the micturition circuitry is different to that by sensory transmission from hindlimb and perineal regions during micturition. We hypothesize that more than one population of sacral PAD-mediating interneurones is involved. PMID:9852338

  10. Autocateterismo vesical intermitente en la lesión medular

    OpenAIRE

    Assis, Gisela Maria; Faro, Ana Cristina Mancussi e

    2011-01-01

    O autocateterismo vesical intermitente-técnica limpa é uma técnica efetiva e segura para o tratamento e a prevenção das complicações vesico-urinárias decorrentes da lesão medular. Embora tenha sido descrita desde 1972, ainda existe resistência por parte dos profissionais de saúde em relação à sua utilização. Relataremos, no presente estudo, a metodologia utilizada no treinamento e na motivação dos pacientes para a utilização da técnica em um projeto de assistência de enfermagem clínica e volu...

  11. Vesical Artery Embolization in Haemorrhagic Cystitis in Children

    Energy Technology Data Exchange (ETDEWEB)

    García-Gámez, Andrés, E-mail: agargamez@gmail.com; Bermúdez Bencerrey, Patricia, E-mail: PBERMUDE@clinic.ub.es [Hospital Clinic (Spain); Brio-Sanagustin, Sonia, E-mail: sbrio@santpau.cat [Hospital de la Santa Creu y Sant Pau (Spain); Guerrero Vara, Rubén, E-mail: rguerrerov@santpau.cat [Hospital Clinic (Spain); Sisinni, Luisa, E-mail: lsisinni@santpau.cat [Hospital de la Santa Creu y Sant Pau (Spain); Stuart, Sam, E-mail: sam.stuart@gosh.nhs.uk; Roebuck, Derek, E-mail: Derek.Roebuck@gosh.nhs.uk [Great Ormond Street Hospital for Children (United Kingdom); Gómez Muñoz, Fernando, E-mail: FEGOMEZ@clinic.ub.es [Hospital Clinic (Spain)

    2016-07-15

    Haemorrhagic cystitis is an uncommon and, in its severe form, potentially life-threatening complication of haematopoietic stem cell transplantation or cancer therapy in children. The severe form involves macroscopic haematuria with blood clots, urinary obstruction and/or renal impairment. There are many therapeutic options to treat acute haemorrhage, but only recombinant factor VII has a high level of clinical evidence in children. Supraselective vesical artery embolization (SVAE) is an increasingly used therapeutic procedure for controlling haemorrhage in adults, but is less commonly used in children. This might be due to several factors, such as the invasive nature of the procedure, lack of appropriate medical experience and possible long-term side effects. We present three cases of children successfully treated by means of effective SVAE.

  12. New Surgical Approach for treatment of complex vesicovaginal fistula. Vesical autoplasty; Avances en la cirugia de la fistula vesicovaginal compleja. Autoplastia vesical

    Energy Technology Data Exchange (ETDEWEB)

    Gil-Vernet Vila, J. M.

    2009-07-01

    Although currently complex ve sico-vaginal fistulae are an uncommon finding, their solution still remains a problem since no effective surgical technique is yet available. We describe a new vesical autoplasty procedure for solving this entity. Once the fistulae has been thoroughly resected and its borders have been unfolded, a graft is obtained from the posterior-superior vesical wall, which is then slid down to the vesical neck thereby covering great extensions where tissue has been lost, even in the presence of low-capacity bladders. This new operation has led to a 100% cure rate of the 42 consecutive cases of vesico-vaginal fistulae operated on and that had undergone repeated surgery using other thecniques. (Author) 8 refs.

  13. On-screen vector-based ultrasound assessment of vesical neck movement.

    Science.gov (United States)

    Reddy, A P; DeLancey, J O; Zwica, L M; Ashton-Miller, J A

    2001-07-01

    We sought to develop a vector-based assessment to determine the magnitude and direction of bladder neck movements, as well as to assess whether probe movement relative to the pubis needs to be taken into account. Ten nulliparous continent, 10 primiparous continent, and 10 primiparous stress-incontinent women were recruited. Perineal ultrasound scanning was performed in standing women while they were resting, performing the Valsalva maneuver, coughing, and performing Kegel exercises. A direct on-screen assessment of bladder neck displacement from rest to the peak of dynamic activity relative to the pubic axis was made. Transducer movement was assessed by measuring the displacement of the pubic bone. The method was feasible because measurements were possible in all 30 subjects. Vesical neck and pubic point movement in millimeters (+/- SD) and the percentage error if pubic point movement is not accounted for are as follow: strain, vesical neck 16.9 +/- 6.1 and pubic point 4.8 +/- 3.9, 28%; cough, vesical neck 10.2 +/- 5.4, pubic point 2.9 +/- 3.4, 33%; Kegel exercise, vesical neck 7.0 +/- 3.6 and pubic point 0.7 +/- 1.4, 37%. Similar discrepancies in angle were found and are presented. Uncorrected direction of vesical neck and pubic point movement in degrees and the percentage error if pubic point movement is not accounted for are as follow: strain, vesical neck 169.4 +/- 18.5 and pubic point 214.0 +/- 56.7, 18%; cough, vesical neck 162.0 +/- 12.8, pubic point 238.4 +/- 27.4, 22%; Kegel exercise, vesical neck -0.9 +/- 12.7 and pubic point -4.8 +/- 20.6, 87%. Test-retest reliability correlations were more than an r value of 0.7 in all measures and 86% of the measurements greater than 0.8. The vector-based system provides a simple method for quantifying distance and direction of vesical neck motion, as well as localizing the resting vesical neck position.

  14. Endometriose Simulando Neoplasia Vesical Endometriosis Simulating Bladder Cancer

    Directory of Open Access Journals (Sweden)

    Marcos Tobias-Machado

    2000-04-01

    Full Text Available Objetivo: o acometimento do trato urinário pela endometriose é raro e quando ocorre, a bexiga é o órgão mais freqüentemente afetado. Observamos que algumas pacientes têm sido encaminhadas com o diagnóstico clínico de neoplasia vesical. Em geral, a literatura mostra relatos isolados de casos, tornando difícil a padronização de condutas. Tivemos por objetivo apresentar nossa experiência, mostrando os principais aspectos diagnósticos e terapêuticos desta entidade clínica. Métodos: avaliamos retrospectivamente os casos com diagnóstico de endometriose vesical por meio do arquivo do Departamento de Patologia, fazendo revisão dos dados clínicos de prontuário e convocando as pacientes para seguimento ambulatorial após tratamento. Resultados: os principais sinais e sintomas apresentados pelas pacientes foram disúria cíclica, massa e dor pélvica crônica. O diagnóstico presuntivo foi realizado mediante ultra-sonografia (USG, tomografia computadorizada (TC de abdome, cistoscopia e laparoscopia. O diagnóstico definitivo com confirmação anátomo-patológica foi obtido pela ressecção endoscópica em 3 casos e biópsia laparoscópica em 1 caso. As opções terapêuticas foram o tratamento medicamentoso exclusivo e a ressecção da lesão empregando a via endoscópica ou cistectomia parcial, sempre complementados por tratamento clínico adjuvante. Conclusões: revisamos os principais aspectos clínicos e terapêuticos da endometriose do trato urinário, lembrando que esta representa um importante diagnóstico diferencial de tumor vesical em mulheres jovens na idade reprodutiva.Purpose: urinary tract involvement by endometriosis is uncommon and the bladder is the most common site. We observed that clinical misdiagnosis of bladder cancer frequently is made. Because the disease is generally described in case reports there is not a consensual management. We present and discuss our experience of diagnostic and therapeutic issues

  15. Temporal changes in micturition and bladder contractility after sucrose diuresis and streptozotocin-induced diabetes mellitus in rats.

    Science.gov (United States)

    Tammela, T L; Leggett, R E; Levin, R M; Longhurst, P A

    1995-06-01

    Studies were done to compare the acute effects of streptozotocin-induced diabetes and sucrose consumption on micturition, bladder mass and contractile responses of bladder strips to field stimulation and contractile agonists. Micturition changes occurred gradually in diabetic rats, reached maximal values within 7 to 14 days, and were accompanied by significant increases in bladder mass after 7 days. Bladder strips from diabetics responded to field stimulation, carbachol and KCl with significantly greater contractions than did those from controls within 7 days. Sucrose-drinking rats had maximal increases in fluid consumption and micturition frequency on the first night after starting treatment. Increases in micturition volumes were slower to develop than in diabetics. Bladder mass was significantly increased 30 and 60 days after starting sucrose treatment. Bladder strips from sucrose-drinking rats responded to field stimulation and carbachol with significantly greater contractions than did those from controls only after 60 days. Monitoring of drinking and micturition patterns established that diabetic rats drink and urinate during both the dark and light cycles. In contrast, control and sucrose-drinking rats drink and urinate principally at night. The results demonstrate that differences in bladder function between diabetic and sucrose drinking rats are apparent during the first month after treatment begins. The data suggest that the effects of diabetes and sucrose consumption on contractile bladder function are related to the diuresis-induced increases in bladder mass.

  16. Increased heart rate caused by atrial pacing with the closed-loop stimulation function prevented micturition syncope

    Directory of Open Access Journals (Sweden)

    Tatsuo Haraki, MD,PhD

    2013-10-01

    Full Text Available A 70-year-old man had been experiencing syncope several times a year. We implanted a DDD pacemaker with closed-loop stimulation (CLS function. When he urinated early in the morning, his increased atrial pacing rates elevated his heart rate (HR during and after micturition. After implantation of the DDD-CLS mode, he did not experience symptoms. In contrast, in the DDD-R mode, his intrinsic HR changed to atrial pacing after micturition but decreased to the basal rate within 2 min, and he experienced a sense of cold perspiration and presyncope. Increased HRs caused by atrial pacing with the CLS function were useful in the prevention of micturition syncope.

  17. Diuretic renogram in the evaluation of uretero-vesical junction

    Energy Technology Data Exchange (ETDEWEB)

    Nonomura, Katsuya; Nantani, Masami; Taniguchi, Kotaro; Koyanagi, Tomohiko; Ito, Kazuo (Hokkaido Univ., Sapporo (Japan). School of Medicine)

    1984-04-01

    For assessing the drainage through the uretero-vesical junction (UVJ), diuretic renogram (DR) was performed in twenty-five cases of non-refluxing megaloureter and post-ureteral reimplantation. 1) DR analysis of UVJ should be done with the region of interest in the renal pelvis plus the ureter without overlapping the bladder. Although the excretion pattern of the renal pelvis in the cases of marked dilated ureter may disclose no obstruction, that of the renal pelvis plus the ureter will disclose no obstruction, that of the renal pelvis plus the ureter will disclose obstruction by ureteral RI stasis. 2) Compared to excretory urogram and other clinical examination, a poorly functioning kidney tends to show an obstructed pattern (false positive) and six of nine cases of non-refluxing megaloureter had no obstruction in the empty state of the bladder (false negative). 3) Non-refluxing megaloureter which showed non-obstructed pattern with bladder drainage turned out to be obstructed when the bladder is filled with saline. Thus, the state of bladder filling must be taken into consideration when evaluating the UVJ drainage by DR. It will play a valuable role in further study of UVJ kinetic when combined with other urodynamical examination.

  18. The long term outcome of micturition, defecation and sexual function after spinal surgery for cauda equina syndrome.

    Directory of Open Access Journals (Sweden)

    Nina S Korse

    Full Text Available Cauda equina syndrome (CES is a rare neurologic complication of lumbar herniated disc for which emergency surgical decompression should be undertaken. Despite the common belief that the restoration of functions that are affected by CES can take several years postoperatively, follow up seldom exceeds the first year after surgery. Long term outcome of especially micturition, defecation and sexual function-which are by definition affected in CES-are unknown. The aim of this study is to evaluate 1 postoperative long term outcome of micturition, defecation and sexual function in CES patients 2 attitude of patients towards received hospital care with regard to (recovery of these functions.CES patients were selected by screening the records of all patients operated on lumbar herniated disc in our university hospital between 1995-2010. A questionnaire was sent to the selected CES patients evaluating current complaints of micturition, defecation and sexual function and attitude towards delivered care with focus on micturition, defecation and sexual function.Thirty-seven of 66 eligible CES patients were included (response rate 71%, inclusion rate 56%. Median time after surgery was 13.8 years (range 5.8-21.8 years. Dysfunction at follow up was highly prevalent: 38% micturition dysfunction, 43% defecation dysfunction and 54% sexual dysfunction. Younger age at presentation was associated with sexual dysfunction at follow up: for every year younger at presentation, odds ratio for sexual dysfunction at follow up was 1.11 (p = 0.035. Other associations with outcome were not identified. Two-third of the CES patients wished their neurosurgeon had given them more prognostic information about micturition, defecation and sexual function.The presented data demonstrate that dysfunction of micturition, defecation and sexual function are still highly prevalent in a large number of CES patients even years postoperatively. These alarming follow up data probably have a

  19. Progressive changes in detrusor function and micturition patterns with chroinc bladder ischemia

    Directory of Open Access Journals (Sweden)

    Zuohui Zhao

    2016-07-01

    Full Text Available Purpose: Lower urinary tract symptoms (LUTS are bothersome constellation of voiding symptoms in men and women as they age. Multiple factors and comorbidities are attributed to this problem but underlying mechanisms of nonobstructive nonneurogenic detrusor overactivity, detrusor underactivity and LUTS remain largely unknown. Our goal was to characterize detrusor function and voiding patterns in relation to muscarinic receptors expression, nerve fiber density, and neural ultrastructure in chronic bladder ischemia. Materials and Methods: Iliac artery atherosclerosis and bladder ischemia were produced in male Sprague-Dawley rats. At 8 and 16 weeks after ischemia, micturition patterns and cystometrograms were recorded in conscious rats then bladder blood flow and nonvoiding spontaneous contractions were measured under general anesthesia. Bladder tissues were processed for Western blotting, immunostaining, and transmission electron microscopy. Results: Bladder responses to ischemic insult depended on the duration of ischemia. Micturition patterns and cystometric changes at 8-week ischemia suggested detrusor overactivity, while voiding behavior and cystometrograms at 16-week ischemia implied abnormal detrusor function resembling underactivity. Upregulation of muscarinic M2 receptor was found after 8- and 16 weeks of ischemia. Downregulation of M3 and upregulation of M1 were detected at 16-week ischemia. Neural structural damage and marked neurodegeneration were found after 8 and 16 weeks of ischemia, respectively. Conclusions: Prolonged ischemia may be a mediating variable in progression of overactive bladder to dysfunctional patterns similar to detrusor underactivity. The mechanism appears to involve differential expression of M1, M2, and M3 receptors, neural structural injury, and progressive loss of nerve fibers.

  20. The functional anatomy of the uretero-vesical junction. A historical review.

    Science.gov (United States)

    Abdel-Halim, Rabie E; Abdel-Maguid, Thoraya E

    2003-08-01

    This paper evaluates the progress of anatomy and dissection during the Middle Ages both in Europe and in the Muslim World. For that purpose, the functional anatomy of the ureterovesical junction and the mechanism of micturition were studied both in the works of Galen (130-200 AD) and in the works of 6 Islamic medical scholars who lived in the period from the ninth to the thirteenth centuries AD (Alrazi, Alzahrawi, Ibn Sina, Al-Baghdadi, Ibn El Nefis and Ibn El Quff). The study relied, only, on original sources in the form of authentic editions and manuscripts. In general, the ideas and findings of those 6 Islamic physicians, as regard the anti-reflux and the micturition mechanisms, differed and contradicted with those of Galen but conformed well with our present day concepts.

  1. Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Yoke-Chen; Wang, James D. [Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States); Svoboda, Kathy K. [Texas A and M University, Baylor College of Dentistry, Center for Craniofacial Research 3302 Gaston Ave, Dallas, Texas 75246 (United States); Casillas, Robert P. [MRIGlobal, 425 Volker Boulevard, Kansas City, MO 64110 (United States); Laskin, Jeffrey D. [UMDNJ-Robert Wood Johnson Medical School, Environmental and Occupational Medicine, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States); Gordon, Marion K. [Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States); Gerecke, Donald R., E-mail: gerecke@eohsi.rutgers.edu [Rutgers University, Pharmacology and Toxicology, 170 Frelinghuysen Rd, Piscataway, NJ 08854 (United States)

    2013-04-15

    The endoplasmic reticulum (ER) stress response is a cell survival pathway upregulated when cells are under severe stress. Severely damaged mouse ear skin exposed to the vesicant, sulfur mustard (bis-2-chloroethyl sulfide, SM), resulted in increased expression of ER chaperone proteins that accompany misfolded and incorrectly made proteins targeted for degradation. Time course studies with SM using the mouse ear vesicant model (MEVM) showed progressive histopathologic changes including edema, separation of the epidermis from the dermis, persistent inflammation, upregulation of laminin γ2 (one of the chains of laminin-332, a heterotrimeric skin glycoprotein required for wound repair), and delayed wound healing from 24 h to 168 h post exposure. This was associated with time related increased expression of the cell survival ER stress marker, GRP78/BiP, and the ER stress apoptosis marker, GADD153/CHOP, suggesting simultaneous activation of both cell survival and non-mitochondrial apoptosis pathways. Dual immunofluorescence labeling of a keratinocyte migration promoting protein, laminin γ2 and GRP78/BIP, showed colocalization of the two molecules 72 h post exposure indicating that the laminin γ2 was misfolded after SM exposure and trapped within the ER. Taken together, these data show that ER stress is induced in mouse skin within 24 h of vesicant exposure in a defensive response to promote cell survival; however, it appears that this response is rapidly overwhelmed by the apoptotic pathway as a consequence of severe SM-induced injury. - Highlights: ► We demonstrated ER stress response in the mouse ear vesicant model. ► We described the asymmetrical nature of wound repair in the MEVM. ► We identified the distribution of various ER stress markers in the MEVM.

  2. Laparoscopic conservative treatment of colo-vesical fistula: a new surgical approach

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    Cochetti Giovanni

    2013-09-01

    Full Text Available Introduction The standard treatment of colo-vesical fistula is the exeresis of fistula, suture of bladder wall, colic resection with or without temporary colostomy. Usually the approach is open because conversion rates and morbidity are lower than laparoscopy. The aim of video is to show the steps of a new mini-invasive approach of colo-vesical fistula without colic resection. Materials and Methods A 69 years old male underwent laparoscopic conservative treatment of colo-vesical fistula due to endoscopic polipectomy in sigmoid diverticulum. 12 mm trocar for the camera was placed at the umbilicus, two 10 mm trocars were placed along bisiliac line and 5 mm port was placed along left emiclavear line; Trendelenburg position was 20°. The fistulous loop was carefully isolated, clipped with Hem-o-lock® clips and removed. Since diverticular disease appeared slight and no inflammation signs were evident, colon resection was not performed. We sutured and sinked the sigmoid wall; after curettage of the fistula site, the bladder wall was sutured. Fat tissue was placed between sigmoid and bladder wall to reduce the risk of fistula recurrence. Results Operative time, estimated blood loss, catheterization time, time to flatus and hospital stay were respectively 210 minutes, 300 mL, 10 days, 48 h and 8 days. The histological examination showed colonic inflammatory and necrotic tissue. No complications or fistula recurrence occurred at 54 months follow-up. Conclusions The laparoscopic conservative treatment of colo-vesical fistula is a safe and feasible technique, in particular when the diverticular disease is limited and the fistula is not due to diverticulitis.

  3. Lesiones anatomo-patologicas en cuyes intoxicados experimentalmente con Pteridium aquilinum como modelo animal para bovinos con hematuria vesical enzootica bovina

    National Research Council Canada - National Science Library

    Ramos G., Mariella; Chavera C., Alfonso; Tabacchi N., Luis; Huaman U., Hector; Sandoval C., Nieves; Rodriguez G., Jose

    2012-01-01

    ...) intoxicados experimentalmente por via oral con pellets conteniendo Pteridium aquilinum (Pa) por 135 dias. El cuy se empleo como modelo experimental para bovinos con Hematuria Vesical Enzootica Bovina...

  4. Functional Magnetic Resonance Imaging with Concurrent Urodynamic Testing Identifies Brain Structures Involved in Micturition Cycle in Patients with Multiple Sclerosis.

    Science.gov (United States)

    Khavari, Rose; Karmonik, Christof; Shy, Michael; Fletcher, Sophie; Boone, Timothy

    2017-02-01

    Neurogenic lower urinary tract dysfunction, which is common in patients with multiple sclerosis, has a significant impact on quality of life. In this study we sought to determine brain activity processes during the micturition cycle in female patients with multiple sclerosis and neurogenic lower urinary tract dysfunction. We report brain activity on functional magnetic resonance imaging and simultaneous urodynamic testing in 23 ambulatory female patients with multiple sclerosis. Individual functional magnetic resonance imaging activation maps at strong desire to void and at initiation of voiding were calculated and averaged at Montreal Neuroimaging Institute. Areas of significant activation were identified in these average maps. Subgroup analysis was performed in patients with elicitable neurogenic detrusor overactivity or detrusor-sphincter dyssynergia. Group analysis of all patients at strong desire to void yielded areas of activation in regions associated with executive function (frontal gyrus), emotional regulation (cingulate gyrus) and motor control (putamen, cerebellum and precuneus). Comparison of the average change in activation between previously reported healthy controls and patients with multiple sclerosis showed predominantly stronger, more focal activation in the former and lower, more diffused activation in the latter. Patients with multiple sclerosis who had demonstrable neurogenic detrusor overactivity and detrusor-sphincter dyssynergia showed a trend toward distinct brain activation at full urge and at initiation of voiding respectively. We successfully studied brain activation during the entire micturition cycle in female patients with neurogenic lower urinary tract dysfunction and multiple sclerosis using a concurrent functional magnetic resonance imaging/urodynamic testing platform. Understanding the central neural processes involved in specific parts of micturition in patients with neurogenic lower urinary tract dysfunction may identify areas

  5. Resultados de la ileocistoplastia ortotópica en pacientes con tumor vesical Orthotopic ileocystoplasty results in patient presenting vesical tumor

    Directory of Open Access Journals (Sweden)

    Adolfo García García

    2010-03-01

    Full Text Available INTRODUCCIÓN. El cáncer de la vejiga es considerado un problema de salud tanto en Cuba como en el mundo. La cistectomía radical y sus variantes terapéuticas tienen la finalidad de curar o controlar la enfermedad, y conllevan la creación de un reservorio lo más semejante posible a la vejiga, por lo que se trabaja en la creación y perfeccionamiento de neovejigas a partir de un segmentointestinal. El objetivo de esta investigación fue evaluar los resultados de la ileocistoplastia ortotópica como procedimiento derivativo de la orina, después de la cistectomía total. MÉTODOS. Se realizó un estudio descriptivo, retrospectivo y prospectivo de 40 pacientes tratados en el Hospital «Hermanos Ameijeiras», en La Habana, entre los años 2000 y 2008. La fuente de información fueron los expedientes clínicos de los pacientes, y los datos se procesaron por medios automatizados. RESULTADOS. La mayor incidencia se encontró en los pacientes con 65 años de edad. La enuresis fue la forma de incontinencia urinaria que predominó y la mayoría de los pacientes tenían micciones voluntarias. Siete pacientes presentaron hidronefrosis y las fístulas del reservorio se relacionaron con la radioterapia. La mortalidad fue del 7,5 %. CONCLUSIONES. La ileocistoplastia ortotópica es un sustituto vesical aceptable en los pacientes con tumores vesicales.INTRODUCTION: The bladder cancer is considered a health problem in Cuba and worldwide. The aim of radical cystectomy and its therapeutical variants is to cure or control the disease and it is necessary the creation of a reservoir very similar to bladder and nowadays it is working in creation and improvement of the neo-bladders from an intestinal segment. The aim of present research was to assess the orthotopic ileocystoplasty results as urine derivative procedure after total cystectomy. METHODS: A prospective, retrospective and descriptive study was conducted in 40 patients seen in "Hermanos Ameijeiras

  6. Efeito do cloridrato de oxibutinina na hiperatividade vesical conseqüente a cistite hemorrágica Effects of oxybutynin in bladder hyperactivity caused by hemorrhagic cystitis

    Directory of Open Access Journals (Sweden)

    EK Mizuma

    2003-01-01

    ção dos parâmetros estudados depois da droga mostrou: Fc - p= 0,055; Ic - p=0,0002; Te - p=0,957; Tc - p=0,181; Cv - p=0,206. CONCLUSÕES: O cloridrato de oxibutinina nesse modelo experimental atuou de forma a alterar somente a freqüência das miccções, controlando a hiperatividade e não promovendo alterações nos demais parâmetros estudados.BACKGROUND: The oxybutynin is an anticholinergic agent that binds to muscarinic receptors of bladder muscle promoting an antispasmodic effect. As a consequence there is an increase in bladder capacity, reduction in frequency and a blockade in the initial stimuli of miction. OBJECTIVE: To verify the action of oxybutynin on bladder overactivity due to hemorrhagic cystitis. METHODS: Hemorrhagic cystitis was provoked through an intraperitoneal injection of 200mg/kg of cyclophosphamide in 10 female rats, weighting 200-250g, 24h before the experiment. The control group of 5 female rats received an intraperitoneal injection of 0.5ml of saline. In the experiment the animals were anesthetized with 1.25mg/kg of urethane followed by a cystostomy with a P-50 catheter connected in Y to an infusion pump (rate of infusion - 0.3ml/min and to a polygraph to register bladder pressure. The parameters studied were: frequency of bladder contraction (Fc, contraction intensity (Ci, time of bladder filling (Tf and contraction (Tc, and vesical capacity (Vc (Tf x flow. We determined the mean value for each parameter following of 10min of observation. After these determinations all rats received 71mg/kg of oxybutynin chloride through nasogastric tubing and 1h afterward the measures were repeated. The data were compared with the Kruskal-Wallis test considering significant a p<0.05. RESULTS: A comparison both groups (control versus experimental before the use of oxybutynin showed the following values of p: Fc - 0.007; Ci - 0.0002; Tf - 0.768; Tc - 0.492; Vc - 0.055. After the use of oxybutynin the corresponding values were: Fc - p=0.055; Ci - p=0.0002; Tf

  7. Tratamento cirúrgico da litíase vesical: revisão de literatura

    Directory of Open Access Journals (Sweden)

    Fabio Cesar Miranda Torricelli

    Full Text Available Cálculos vesicais são raros e a maioria dos casos ocorre em homens adultos com obstrução infravesical. Atualmente, existem poucos dados sobre o melhor tratamento desta doença. O objetivo desta revisão foi discutir alguns aspectos da patogênese e abordar o tratamento da litíase vesical. Uma ampla pesquisa na base de dados da "National Library of Medicine"/Pubmed foi realizada com os seguintes unitermos e descritores: vesical ou bexiga associados a cálculo, pedra ou litíase, e cistolitotripsia. Cento e setenta e um artigos foram identificados. Os artigos foram avaliados independentemente por dois revisores com experiência em urolitíase. Foram incluídos quando os resultados, complicações e seguimento foram claramente reportados. No final, 32 estudos preencheram os critérios de inclusão. Nota-se que diversas opções para o tratamento da litíase vesical estão disponíveis, porém não há estudos randomizados comparando-as. Diferentes taxas de pacientes livres de cálculo são descritas, sendo: litotripsia extracorpórea com ondas de choque (75-100%, cistolitotripsia transureteroscópica (63-100%, cistolitotripsia percutânea (89-100% e cirurgia aberta (100%. O acesso percutâneo apresenta menor morbidade com resultados semelhantes ao tratamento transuretral, enquanto a litotrispsia extracorpórea apresenta as menores de taxas de eliminação de cálculos e fica reservada aos pacientes de alto risco cirúrgico.

  8. General guidelines for medically screening mixed population groups potentially exposed to nerve or vesicant agents

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.P.; Munro, N.B. (Oak Ridge National Lab., TN (United States)); Sidell, F.R. (Army Medical Research Inst. of Chemical Defense, Aberdeen Proving Ground, MD (United States)); Leffingwell, S.S. (Centers for Disease Control, Atlanta, GA (United States). Center for Environmental Health and Injury Control)

    1992-01-01

    A number of state and local planners have requested guidance on screening protocols and have expressed interest in sampling body fluids from exposed or potentially exposed individuals as a means of estimating agent dose. These guidelines have been developed to provide a clear statement that could be used by state and local emergency response personnel in the event of a nerve or vesicant agent incident resulting in off-post contamination; maximum protection from harm is the goal. The assumption is that any population group so exposed would be heterogeneous for age, gender, reproductive status, and state of health.

  9. Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries

    Energy Technology Data Exchange (ETDEWEB)

    Tewari-Singh, Neera, E-mail: Neera.Tewari-Singh@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Jain, Anil K., E-mail: Anil.Jain@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Inturi, Swetha, E-mail: Swetha.Inturi@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Ammar, David A., E-mail: David.Ammar@ucdenver.edu [Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Agarwal, Chapla, E-mail: Chapla.Agarwal@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Tyagi, Puneet, E-mail: Puneet.Tyagi@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Kompella, Uday B., E-mail: Uday.Kompella@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States); Enzenauer, Robert W., E-mail: Robert.Enzenauer@ucdenver.edu [Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Petrash, J. Mark, E-mail: Mark.Petrash@ucdenver.edu [Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045 (United States); Agarwal, Rajesh, E-mail: Rajesh.Agarwal@ucdenver.edu [Department of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO 80045 (United States)

    2012-10-01

    There are no effective and approved therapies against devastating ocular injuries caused by vesicating chemical agents sulfur mustard (SM) and nitrogen mustard (NM). Herein, studies were carried out in rabbit corneal cultures to establish relevant ocular injury biomarkers with NM for screening potential efficacious agents in laboratory settings. NM (100 nmol) exposure of the corneas for 2 h (cultured for 24 h), showed increases in epithelial thickness, ulceration, apoptotic cell death, epithelial detachment microbullae formation, and the levels of VEGF, cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9). Employing these biomarkers, efficacy studies were performed with agent treatments 2 h and every 4 h thereafter, for 24 h following NM exposure. Three agents were evaluated, including prescription drugs dexamethasone (0.1%; anti-inflammatory steroid) and doxycycline (100 nmol; antibiotic and MMP inhibitor) that have been studied earlier for treating vesicant-induced eye injuries. We also examined silibinin (100 μg), a non-toxic natural flavanone found to be effective in treating SM analog-induced skin injuries in our earlier studies. Treatments of doxycycline + dexamethasone, and silibinin were more effective than doxycycline or dexamethasone alone in reversing NM-induced epithelial thickening, microbullae formation, apoptotic cell death, and MMP-9 elevation. However, dexamethasone and silibinin alone were more effective in reversing NM-induced VEGF levels. Doxycycline, dexamethasone and silibinin were all effective in reversing NM-induced COX-2 levels. Apart from therapeutic efficacy of doxycycline and dexamethasone, these results show strong multifunctional efficacy of silibinin in reversing NM-induced ocular injuries, which could help develop effective and safe therapeutics against ocular injuries by vesicants. -- Highlights: ► Established injury biomarkers in rabbit corneal culture with nitrogen mustard (NM) ► This NM model is a cost effective

  10. Superselective embolization of the inferior vesical artery for the treatment of intractable hematuria from pelvic malignancy: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyun Jung; Jeon, Eui Yong [Hallym Univ. Sacred Heart Hospital/Hallym Univ. College of Medicine, Anyang, (Korea, Republic of); Choi, Sun Young [Ewha Womans Univ. Seoul (Korea, Republic of); Han, Kum Hyun [Inje Univ. Ilsan Paik Hospital/Inje Univ. College of Medicine, Goyang (Korea, Republic of)

    2012-05-15

    Intractable hematuria in from pelvic malignancy can be managed with conservative treatment in most patients. However, when treatment fails, surgical intervention may be required. Unfortunately, in most cases, the general condition of most patients is unfavorable for major surgery, with many patients having an inoperable status. We present two cases where intractable hematuria was successfully controlled by bilateral embolization of the inferior vesical artery with polyvinyl alcohol particles. Hematuria did not recur during the subsequent period and no complication was observed. Thus, bilateral embolization of the inferior vesical artery should be considered as an alternative method for the treatment of massive intractable hematuria caused by pelvic malignancy.

  11. A técnica limpa do autocateterismo vesical intermitente: descrição do procedimento realizado pelos pacientes com lesão medular La tecnica limpia del autocateterismo vesical intermitente: descripción del preocdimento realizado por los pacientes com lesion medular The clean techinique of vesical autocatheterism inttermitent: description of the procedure accomphished by the pacient with medullar injury

    Directory of Open Access Journals (Sweden)

    Mitiko Moroóka

    2002-12-01

    Full Text Available Neste trabalho, as autoras descrevem a seqüência da técnica e os materiais utilizados na realização do autocateterismo vesical intermitente - técnica limpa. As informações foram obtidas junto aos pacientes que realizam este procedimento e que foram orientados no Serviço de Atendimento Interdisciplinar ao paciente com lesão medular traumática. Pretendemos, através da divulgação dos resultados, contribuir para a ampliação do conhecimento sobre o autocateterismo vesical e subsidiar a prática aos pacientes iniciantes neste processo terapêutico.En este trabajo, las autoras describen la secuencia de la técnica y los materiales utilizados en la realización del autocateterismo vesical intermitente-ténica limpia. Las informaciones fueron orientadas em el Servicio de Atendimiento Interdisciplinar al paciente con lesión medular traumática. Pretendemos, através de la divulgaciín de los resultados, contribuir para la ampliación del conocimiento sobre el autocateterismo vesical y subvencionar la práctica a los pacientes iniciantes en este procedimento terapéutico, paciente.The present study describes the sequence and its materials used in the vesical autocatheterism intermittent - clean technique. The information were obtained together with the patients, who go through such procedure and were directed to follow the instructions, given by the inter disciplinary Service, attending patients with traumatic medullar injury. The study intends to contribute to increase the knowledge about the vesical autocatheterism and provide to the patients this technique in a therapeutic way.

  12. Toxicity of vesicant agents scheduled for destruction by the chemical stockpile disposal program

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.P.; Griffin, G.D. (Oak Ridge National Lab., TN (United States))

    1992-11-01

    The vesicant agents of the unitary chemical munitions stockpile include various formulations of sulfur mustard [bis-(2-chloroethyl) sulfide; agents H, HD, and HT] and small quantities of the organic arsenical Lewisite [dichloro(2-chlorovinyl)arsine; agent L]. These agents can be dispersed in liquid, aerosol, or vapor form and are capable of producing severe chemical burns upon direct contact with tissue. Moist tissues such as the eyes, respiratory tract, and axillary areas are particularly affected. Available data summarizing acute dose response in humans and laboratory animals are summarized. Vesicant agents are also capable of generating delayed effects such as chronic bronchitis, carcinogenesis, or keratitis/keratopathy of the eye under appropriate conditions of exposure and dose. These effects may not become manifest until years following exposure. Risk analysis derived from carcinogenesis data indicates that sulfur mustard possesses a carcinogenic potency similar to that of benzo[a]pyrene. Because mustard agents are alkylating compounds, they destroy individual cells by reaction with cellular proteins, enzymes, RNA, and DNA. Once begun, tissue reaction is irreversible. Mustard agents are mutagenic; data for cellular and laboratory animal assays are presented. Reproductive effects have not been demonstrated in the offspring of laboratory rats. Acute Lewisite exposure has been implicated in cases of Bowen's disease, an intraepidermal squamous cell carcinoma. Lewisite is not known to generate reproductive or teratogenic effects. 112 refs., 1 fig., 6 tabs.

  13. Value of normalized apparent diffusion coefficient for estimating histological grade of vesical urothelial carcinoma.

    Science.gov (United States)

    Wang, H J; Pui, M H; Guo, Y; Li, S R; Liu, M J; Guan, J; Zhang, X L; Feng, Y

    2014-07-01

    To compare the efficacy of apparent diffusion coefficient (ADC) and normalized ADC (nADC) for estimating the histological grade of vesical urothelial carcinoma and to identify an optimal reference for nADC calculation. Thirty patients with histologically confirmed vesical urothelial carcinomas underwent preoperative diffusion-weighted magnetic resonance imaging (DW-MRI) of the pelvis. nADC of the tumour was calculated as ADC (tumour)/ADC (reference) using urine in the bladder lumen, and the obturator internus and gluteus maximus muscles as reference. Receiver operating characteristic (ROC) curves were constructed and compared to identify an optimal reference for nADC calculation. Both ADC and nADC of low-grade tumours (1.112 ± 0.159 × 10(-3) mm(2)/s, 0.403 ± 0.047 × 10(-3) mm(2)/s) were significantly (p obturator internus (0.960) and gluteus maximus (0.945). nADC is superior to ADC for estimating the histological grade of bladder carcinoma using urine in the bladder lumen as an optimal reference for nADC calculation. Copyright © 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

  14. Kolonialism või kognitiivne kapitalism? / Jelena Vesic, Branislav Dimitrijevic ; interv. Rael Artel, tõlk. Rael Artel

    Index Scriptorium Estoniae

    Vesic, Jelena

    2007-01-01

    Serbia-poolsed kuraatorid Jelena Vesic ja Branislav Dimitrijevic Belgradi Kaasaegse Kunsti Muuseumis avatud Briti Nõukogu initsieeritud briti kaasaegse kunsti näitusest "Breaking Step", kus osaleb 15 kunstnikku, näitusega seotud probleemidest, serbia kaasaegse kunsti näituse Londonis toimumise võimalikkusest

  15. Post-coital burning pain and pain at micturition: early symptoms of partial vaginismus with or without vulvar vestibulitis?

    Science.gov (United States)

    Engman, Maria; Wijma, Klaas; Wijma, Barbro

    2008-01-01

    Twenty-four women with partial vaginismus with or without vulvar vestibulitis participated in a semi-structured telephone interview concerning early signs and development of their pain symptoms during/after intercourse. At the onset of the problem, pain after intercourse was more common than pain during penetration. Pain intensity during penetration increased from the onset of the problem to when the women ceased having intercourse. Pain during penetration lasted for 1 minute, and was most often described as sharp/incisive/bursting, while pain after intercourse had a duration of 2 hours and was described as burning and/or smarting. Post-coital pain during micturition was described by 70% of the women.

  16. Uso excessivo do cateter vesical em pacientes internados em enfermarias de hospital universitário

    Directory of Open Access Journals (Sweden)

    Lucieni de Oliveira Conterno

    2011-10-01

    Full Text Available Este estudo de corte incluiu 254 pacientes adultos que usaram cateter vesical (CV durante a hospitalização em enfermarias de um hospital universitário. Foram avaliados: utilização do cateter, indicação, tempo de permanência, densidade de infecção urinária, mortalidade e permanência hospitalar. Durante o período de estudo, 14% dos pacientes internados usaram CV, totalizando 1.735 CV-dia. Em 23% dos casos, o procedimento não foi prescrito, nem sua indicação foi documentada. O tempo médio de uso do CV foi de 6,8 dias. Entre os pacientes clínicos, a indicação do CV foi inadequada em 29%; o tempo de permanência foi considerado inadequado em 49% dos pacientes clínicos e em 66,9% dos pacientes cirúrgicos. Pacientes com uso inadequado do CV tiveram mais infecção do trato urinário (RR 1,86 IC95% 1,4 a 3,04 e maior tempo de permanência hospitalar (11,9 e 8,9 dias, p=0,002. O estudo permitiu identificar no processo assistencial falhas potencialmente modificáveis e importantes para a prevenção da infecção do trato urinário por cateter vesical.

  17. A dorsal model for cutaneous vesicant injury by 2-chloroethyl ethyl sulfide using C57BL/6 mice.

    Science.gov (United States)

    Isidore, Myriane A; Castagna, Michael P; Steele, Keith E; Gordon, Richard K; Nambiar, Madhusoodana P

    2007-01-01

    To evaluate stem cell-derived therapeutics for cutaneous vesicant injuries, we developed a dorsal exposure model using C57BL/6 black mice and half-mustard, 2-chloroethyl ethyl sulfide (CEES). The dorsal side of a mouse was exposed to 1-5 microl of CEES for 10 minutes and then decontaminated. The data demonstrate that 3 microl of CEES induced edema and erythema that peaked 24 h post exposure. Histopathology showed a central area of deep injury characterized by severe necrosis of epidermis and dermis. The C57BL/6 is a unique model that can be used to unravel the molecular mechanism of injury, identify the effects of black skin pigmentation, and evaluate the efficacy of stem cell therapeutics for cutaneous vesicant exposure.

  18. Influence of antiplatelet-anticoagulant drugs on the need of blood components transfusion after vesical transurethral resection

    Directory of Open Access Journals (Sweden)

    Alvaro Julio Virseda-Rodríguez

    2015-07-01

    Full Text Available Aims: The effect of the antithrombotic preventive therapy on haemorrhage keeps uncertain. We investigate the influence of the antiplatelet and anticoagulant drugs (AP/AC drugs on the transfusion requirement after vesical transurethral resection (VTUR. We also describe the epidemiology of the blood components transfusion in our department. Materials and Methods: Retrospective observational study of a series of patients needing blood transfusion at the Urology Department between June 2010 and June 2013. Selection of 100 consecutive patients who were transfused after VTUR due to bladder transitional cell carcinoma (BTCC (group A = GA. Control group: 100 consecutive patients who underwent VTUR due to BTCC and were not transfused (group B = GB. Transfusion criteria: Haemoglobin < 8 g/dl + anaemia symptoms. Age, gender, associated AP/AC treatment, secondary diagnoses, toxics, tumour stage and grade were analysed. Results: 212 patients required transfusion of a blood component. 169 were men (79% and 43 women (21%. Median age 77.59 years (SD 9.42, range 50-92. Secondary diagnoses: Diabetes Mellitus 64%, high blood pressure 77%, dyslipidemia 52%. 60% of patients were previously treated with AP/AC drugs. Average Haemoglobin pre-transfusion values: 7.4 g/dl (DE ± 0.7. Average Haemoglobin post-transfusion values: 8.9 g/Dl (DE ± 0.72. Most frequent transfusion indications were bladder cancer (37%, kidney cancer (11%, prostate cancer (8%, benign prostatic hyperplasia (BHP (8%, other urological diagnoses (36%. Intraoperative transfusions indicated by the anaesthesiologist: kidney cancer (33%, BPH (28%. Patients who underwent VTUR due to BTCC were older in GA (77.59 years SD 9.42 than in GB (68.98 years SD 11.78 (p = 0.0001. Similar gender distribution (15 women in GA and 24 in GB. Less patients were asked to keep their treatment with ASA 100mg (AcetylSalicylicAcid in GA (25.64% than in GB (50% (p = 0.0330. More aggressive tumour grade in GA (p = 0.0003 and

  19. Cost-effectiveness analysis of main diagnosis tools in women with overactive bladder. Clinical history, micturition diary and urodynamic study.

    Science.gov (United States)

    López-Fando, L; Carracedo, D; Jiménez, M; Gómez de Vicente, J M; Martínez, L; Gómez-Cañizo, C; Gómez, V; Burgos, F J

    2015-01-01

    The aim of the present clinical research is to analyze, in the light of the best scientific evidence, the performance and the cost of the main diagnostic tools for overactive bladder (OAB). It is an exploratory transversal study in which 199 women diagnosed of OAB between 2006 and 2008 were selected and underwent to following prospective analyses: physical examination, urine analysis, micturition diary (MD) and urodynamic study (UDS). A percentage of 80% was assumed as highly sensitive and a diagnostic difference among tests of 10% would be considered clinically relevant. Tests' sensitivity for diagnosis of OAB was statistically established by two ways: isolated and combined. Besides, the direct and indirect costs of these tests performance were conducted. Cost-effectiveness study of clinical history (CH), MD and US for the diagnosis of OAB was performed. Overall sensitivity for OAB diagnosis is low for the 3 tests used in isolated way, whilst the combination of any two tests shows good overall sensitivity. The combination of CH and MD has appeared as the most cost-effective alternative to OAB diagnosis. For OAB diagnosis, CH-DM combination shows the same sensitivity than the association of either of them with the UDS, but unlike to these, it shows the lowest cost. Copyright © 2013 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  20. Extrofia vesical, una anomalía congénita

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    Roger Rojas Rojas

    2015-12-01

    Full Text Available Se realizó un trabajo descriptivo y representativo de un caso, para el que se utilizó la entrevista, la ultrasonografía y la evaluación del grupo Multidisciplinario de Genética Provincial. La paciente con 23 años de edad, con historia obstetricia de G2 P1 eutócico, clasificado de riesgo genético bajo, se le detectó en el ultrasonido del segundo semestre en la semana de gestación 19.6 una anomalía congénita, diagnosticada como extrofia vesical. Después de encontrado este hallazgo, la gestante fue remitida al Centro Genético Provincial. El equipo facultativo evaluó el caso y decidió la interrupción electiva del embarazo, siendo un feto de 450 gramos del sexo femenino. El resultado final de la anatomía patológica fue: ausencia de fusión del hueso pelviano; malformación de la vulva, clítoris prominente, labios mayores cortos y abiertos; vejiga insertada en la pared abdominal.

  1. Primary Intramural Vesical Endometriosis Mimicking Urothelial Carcinoma in a Middle Aged Female

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    Shirazi N

    2015-10-01

    Full Text Available Endometriosis is the presence of ectopic endometrial tissue outside the uterus. Presence of endometrial glands and/or stroma may interfere with the normal physiological process by their infiltrative nature or by forming adhesions. Endometriosis occurs in 15-20% of women of child bearing age and commonly involves the ovaries, utero-sacral ligaments, fallopian tubes, rectum, scar sites and cervico-vaginal regions. Incidence of urinary tract involvement is estimated to be 1%. We report a case of a 38 year female presenting with low back pain, single episode of haematuria and burning during micturition. Urine culture was negative. There was no past history of pelvic surgery. On cystoscopy, a growth was visualised in the posterior urinary bladder wall suspicious of neoplastic origin. Tansurethral resection of bladder nodule was done and sent for histopathology, on which it was diagnosed as endometriosis. The case merits interest due to its atypical clinical presentation and the rarity of the lesion at this site.

  2. ¿Deben realizarse las ecografías renal y vesical en pacientes con mamelones preauriculares? Should renal and vesical ultrasound be performed in patients with preauricular tags?

    Directory of Open Access Journals (Sweden)

    Marcela Tombesi

    2008-06-01

    Full Text Available Introducción: Los niños con malformaciones menores del pabellón auricular son estudiados habitualmente con ecografías renal y vesical, existiendo controversias en cuanto a la validez de esta práctica. Objetivo: Determinar si la prevalencia de malformaciones del tracto urinario es mayor entre niños con mamelones preauriculares aislados que entre aquellos que no los presentan. Población, material y métodos: Entre Junio de 1996 y Junio de 2006, 92 niños con mamelones preauriculares fueron estudiados con ecografía renal y vesical. Se incluyeron en la evaluación a niños sanos con mamelón preauricular aislado. Se excluyeron aquellos con hoyuelos preauriculares, una o más malformaciones menores asociadas, síndromes de malformaciones congénitas múltiples o anomalías mayores identificadas previamente. Ochenta y ocho niños cumplieron con los criterios de inclusión. Para la comparación estadística se utilizó un grupo control histórico de 300 lactantes sanos sin mamelón, estudiados en forma no concurrente con el grupo estudio y que mostró un prevalencia del 1% de malformaciones urinarias. Se realizó una prueba de hipótesis exacta para una proporción utilizando un nivel de significación del 5%, con el software Epidat 3.1. Resultados: Tres de los 88 niños (3,4% con mamelones preauriculares aislados presentaron malformaciones renales : ectopia renal derecha e hidroureteronefrosis, detectada prenatalmente; agenesia renal izquierda, existiendo antecedentes familiares de malformaciones renales y un quiste cortical simple. No se detectaron diferencias estadísticamente significativas con el grupo considerado control histórico (p = 0.11. Conclusión: La prevalencia de malformaciones renales fue similar entre los niños sanos con y sin mamelones preauriculares aislados, por lo que la indicación rutinaria de ecografías renal y vesical no sería necesaria.Introduction: The renal and vesical ultrasound in every patient with

  3. A comparative study of voiding in rat and guinea pig: simultaneous measurement of flow rate and pressure

    NARCIS (Netherlands)

    E. van Asselt (Els); J.M. Groen (Jan); R. van Mastrigt (Ron)

    1995-01-01

    textabstractIn this study, the voiding phase of the micturition cycle in the anesthetized rat and guinea pig is analyzed. In both animals, voiding is characterized by an increase in intravesical pressure and then a decrease, which is accompanied by flow through the urethra and emission of urine. An

  4. Careful Dissection of the Distal Ureter Is Highly Important in Nerve-sparing Radical Pelvic Surgery: A 3D Reconstruction and Immunohistochemical Characterization of the Vesical Plexus.

    Science.gov (United States)

    Kraima, Anne C; Derks, Marloes; Smit, Noeska N; van de Velde, Cornelis J H; Kenter, Gemma G; DeRuiter, Marco C

    2016-06-01

    Radical hysterectomy with pelvic lymphadenectomy (RHL) is the preferred treatment for early-stage cervical cancer. Although oncological outcome is good with regard to recurrence and survival rates, it is well known that RHL might result in postoperative bladder impairments due to autonomic nerve disruption. The pelvic autonomic network has been extensively studied, but the anatomy of nerve fibers branching off the inferior hypogastric plexus to innervate the bladder is less known. Besides, the pathogenesis of bladder dysfunction after RHL is multifactorial but remains unclear. We studied the 3-dimensional anatomy and neuroanatomical composition of the vesical plexus and describe implications for RHL. Six female adult cadaveric pelvises were macroscopically dissected. Additionally, a series of 10 female fetal pelvises (embryonic age, 10-22 weeks) was studied. Paraffin-embedded blocks were transversely sliced in 8-μm sections. (Immuno) histological analysis was performed with hematoxylin and eosin, azan, and antibodies against S-100 (Schwann cells), tyrosine hydroxylase (postganglionic sympathetic fibers), and vasoactive intestinal peptide (postganglionic parasympathetic fibers). The results were 3-dimensionally visualized. The vesical plexus formed a group of nerve fibers branching off the ventral part of the inferior hypogastric plexus to innervate the bladder. In all adult and fetal specimens, the vesical plexus was closely related to the distal ureter and located in both the superficial and deep layers of the vesicouterine ligament. Efferent nerve fibers belonging to the vesical plexus predominantly expressed tyrosine hydroxylase and little vasoactive intestinal peptide. The vesical plexus is located in both layers of the vesicouterine ligament and has a very close relationship with the distal ureter. Complete mobilization of the ureter in RHL might cause bladder dysfunction due to sympathetic and parasympathetic denervation. Hence, the distal ureter should be

  5. Intra-vesical Prostatic Protrusion (IPP) Can Be Reduced by Prostatic Artery Embolization

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Yen-Ting, E-mail: ymerically@gmail.com; Amouyal, Grégory, E-mail: gregamouyal@hotmail.com [Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Vascular and Oncological Interventional Radiology (France); Thiounn, Nicolas, E-mail: nicolas.thiounn@egp.aphp.fr [Assistance Publique Hopitaux de Paris, Hôpital Européen Georges-Pompidou, Urology (France); Pellerin, Olivier, E-mail: olivier.pellerin@aphp.fr [Université Paris Descartes, Sorbonne Paris-Cité (France); Pereira, Héléna, E-mail: helena.pereira@aphp.fr; Giudice, Costantino Del, E-mail: costantino.del-giudice@egp.aphp.fr; Déan, Carole, E-mail: carole.dean@aphp.fr [Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Vascular and Oncological Interventional Radiology (France); Sapoval, Marc, E-mail: marc.sapoval2@aphp.fr [Université Paris Descartes, Sorbonne Paris-Cité (France)

    2016-05-15

    BackgroundProstate artery embolization (PAE) is a new approach to improve lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia. PAE results in global reduction of prostate volume (PV). There are no data available on the efficacy of PAE in reducing intra-vesical prostatic protrusion (IPP), an anatomic feature that is clinically related with bladder outlet obstruction and LUTS.ObjectiveTo assess the results of PAE in patients with significant IPP due to median lobe hyperplasia and to compare the IPSS decrease and IPP change.Material and MethodsProspective analysis of 18 consecutive patients with significant IPP (>5 mm) related to median lobe hyperplasia undergoing PAE using 30–500-μm-calibrated trisacryl microspheres. We measured IPP on sagittal T2-weighted images before and 3 months after PAE. IPSS and clinical results were also evaluated at 3 months.ResultsPAE resulted in significant IPP reduction (1.57 cm ± 0.55 before PAE and 1.30 cm ± 0.46 after PAE, p = 0.0005) (Fig. 1) with no complication. IPSS, quality of life (QoL), total prostate-specific antigen (PSA) level, and PV showed significant reduction after PAE, and maximum urinary flow rate (Q{sub max}) showed significant increase after PAE. No significant change of International Index of Erectile Function (IIEF) for clinical evaluation after PAE. A significant correlation was found between the IPP change and the IPSS change (r = 0.636, p = 0.0045).ConclusionPatients had significant IPP reduction as well as significant symptomatic improvement after PAE, and these improvements were positively correlated.

  6. Prevenção da infeção na pessoa idosa hospitalizada com sonda vesical

    OpenAIRE

    Carvalho, Elodie Lopes

    2014-01-01

    Mestrado, Enfermagem Médico-Cirurgica - Pessoa Idosa, 2014, Escola Superior de Enfermagem de Lisboa Tendo em conta as múltiplas mudanças decorrentes do processo de envelhecimento e à iatrogenia à qual o idoso é sujeito aquando da hospitalização, o risco de ocorrência de infeção nesta população é maior. Nesta medida, este projeto tem como finalidade a redução do risco de infeção na pessoa idosa com sonda vesical, num serviço de Urologia de um hospital de Lisboa e Vale do Tejo, mobilizando a...

  7. Fungal urinary tract infection complicated by acute kidney injury in an infant with intestino-vesical fistula

    Directory of Open Access Journals (Sweden)

    Anna Jakubowska

    2013-08-01

    Full Text Available We report one infant, who in the course of therapy of bacterial urinary tract infection developed fungal UTI and acute kidney injury. It was caused by coexistence of well-known risk factors and additionally intestino-vesical fistula. Appropriate and timely introduced treatment with intravenous fluconazole proved to be therapeutic in the patient. Our report shows that in every case detailed analysis of predisposing factors should be performed and appropriate diagnostic studies ordered, including the possible presence of other – less common – factors, e.g. defects in the gastrointestinal tract.

  8. Fungal urinary tract infection complicated by acute kidney injury in an infant with intestino-vesical fistula.

    Science.gov (United States)

    Jakubowska, Anna; Kiliś-Pstrusińska, Katarzyna; Pukajło-Marczyk, Agnieszka; Samir, Sandra; Bagłaj, Maciej; Zwolińska, Danuta

    2013-08-02

    We report one infant, who in the course of therapy of bacterial urinary tract infection developed fungal UTI and acute kidney injury. It was caused by coexistence of well-known risk factors and additionally intestino-vesical fistula. Appropriate and timely introduced treatment with intravenous fluconazole proved to be therapeutic in the patient. Our report shows that in every case detailed analysis of predisposing factors should be performed and appropriate diagnostic studies ordered, including the possible presence of other - less common - factors, e.g. defects in the gastrointestinal tract.

  9. Evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall obtained by transurethral intravesical echotomography

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    Milošević Radovan

    2007-01-01

    Full Text Available Background/Aim. Transitional cell carcinoma (TCC is the most frequent tumor of the bladder and represents 95−98% of blader neoplasams and 2−3% of all carcinomas in the body. In urogenital oncology more frequent is only prostatic cancer. Evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall represents the clinical base in treatment planning and prognosis. Clinical investigation and convential radiological procedures have a low level of accuracy in estimating the local growth of the tumor. The aims of our investigation were to determine the depth of infiltration of urothelial carcinoma in the vesical wall in the investigated group of patients by transurethral intravesical echotomography (TIE and computerised tomography (CT scan and to compare results obtained by both methods with pathohistological (PH results, and, based on the difference of the results determine which method was more accurate in the evaluation of the depth of infiltration of urothelial carcinoma in the vesical wall. Methods. Thirty patients with TCC of the bladder both genders, aged 51−81 years were involved in our investigation. In all of these patients, radical cystectomy (RC was performed. This was neccessary to provide the defintive PH result. Transurethral intravesical echotomography was performed by ultrasound scanner type 1846 Bruel and Kjaer, sond type 1850, and the CT scan was perfomed by Pace plus, General Electric, U.S.A. The specimen for the definitive PH result obtained by RC includes all standards of the TNM classification. Results. Using CT scan, the most frequent was T1 stage (17 patients or 56.68%. Using TIE, the most frequent was T2 stage (22 patients or 73.33%. After RC the most frequent was T2 stage (21 patients or 70%. The Kolmogorov-Smirnov test, showed a high significant difference between the results obtained using CT and definitive PH results after RC. The same test showed no statistically significant difference between

  10. Rotura vesical intraperitoneal y reparación laparoscópica: ¿Es éste el nuevo gold standard?

    OpenAIRE

    TRONCOSO C,PABLO; Saavedra Z.,Álvaro; Sarras J,Miguel; Rojas R,Francisco

    2012-01-01

    Introducción: Actualmente la laparoscopia es el nuevo paradigma en muchos tratamientos quirúrgicos, pero su rol en trauma urológico es incipiente. Nuestro objetivo es mostrar una técnica factible y segura de cistorrafia laparoscópica por ruptura vesical intraperitoneal contusa. Caso: Un hombre de 28 años consulta por 6 horas de dolor hipogástrico, retención y globo vesical, después de una transgresión alcohólica. Ingresa con creatininemia y parámetros inflamatorios elevados. A pesar de un son...

  11. Infecções urinárias e uso de cateter vesical de demora em unidade pediátrica

    OpenAIRE

    Maria Iranilda Queirós; Maria Aneuma Bastos Cipriano; Míria Conceição Lavinas Santos; Maria Vera Lúcla Moreira Leitão Cardoso

    2011-01-01

    El objetivo fue identificar los agentes etiológicos de infección urinaria en niños sometidos al cateterismo vesical prolongado, ingresados en una Unidad de Cuidados Intensivos, el tiempo de uso y la indicación de ese catéter. La población estuvo constituida por niños atendidos en la Unidad Pedlátríca de un hospital escuela, de julio a diciembre/ 2006. Los datos fueron recogidos de los historiales médicos de 38 niños que usaban sonda vesical prolongada. La principal indicación del cateterismo ...

  12. Endoscopic treatment of vesical and urethral perforations after tension-free vaginal tape (TVT) procedure for female stress urinary incontinence.

    Science.gov (United States)

    Baracat, Fabio; Mitre, Anuar Ibrahim; Kanashiro, Hideki; Montellato, Nelson Ileo Dias

    2005-10-01

    Stress urinary incontinence is a problem that is prevalent in women, and its treatment with minimally invasive techniques using synthetic materials has increased recently, although the procedure has also brought increased occurrence of specific complications such as vesical and urethral perforations. We describe 11 cases of endoscopic correction of vesical and urethral perforations due to the use of synthetic material for the treatment of stress urinary incontinence. Eleven patients were treated for complications after undergoing the TVT(R) (tension-free vaginal tape) procedure; 6 of them had the polypropylene tape inside the bladder, and 5 had erosion of the urethra. Endoscopic resection of the polypropylene tapes was performed on all patients. A 6-month follow-up with cystoscopic control showed that the procedures were successful with complete relief of the symptoms except for 1 patient who persisted with the polypropylene tape in the bladder. This patient underwent a new endoscopic resection, and the cystoscopic control exam was normal 3 months later. Endoscopic resection of intravesical and intraurethral synthetic tapes can be considered a good alternative for the treatment of complications resulting from the TVT procedure.

  13. Infecções urinárias e uso de cateter vesical de demora em unidade pediátrica

    Directory of Open Access Journals (Sweden)

    Maria Iranilda Queirós

    2011-01-01

    Full Text Available El objetivo fue identificar los agentes etiológicos de infección urinaria en niños sometidos al cateterismo vesical prolongado, ingresados en una Unidad de Cuidados Intensivos, el tiempo de uso y la indicación de ese catéter. La población estuvo constituida por niños atendidos en la Unidad Pedlátríca de un hospital escuela, de julio a diciembre/ 2006. Los datos fueron recogidos de los historiales médicos de 38 niños que usaban sonda vesical prolongada. La principal indicación del cateterismo fue el monitoreo del débito urinario. El tiempo de uso del catéter vesical 21 (55,3% fue de 7 a 30 días, 14 (36,8% 30 días. El principal agente etiológico evidenciado fue el Escheríchia con (2,6%. Se constató que los niños que utilizaron catéter vesical prolongado presentaron un considerable índice de infección urinaria de acuerdo con los datos de la literatura.

  14. La ecografía Doppler en la detección de invasión vesical en la placenta percreta: nuestra experiencia

    Directory of Open Access Journals (Sweden)

    P. García Saraví

    2014-07-01

    Conclusión: La ecografía Doppler es un método muy útil para la detección de la invasión vesical en el percretismo placentario. Esta se observa con una vascularización parietal positiva en el Doppler color.

  15. Intra-abdominal pressure: an integrative review.

    Science.gov (United States)

    Milanesi, Rafaela; Caregnato, Rita Catalina Aquino

    2016-01-01

    There is a growing request for measuring intra-abdominal pressure in critically ill patients with acute abdominal pain to be clarified. Summarizing the research results on measurement of vesical intra-abdominal pressure and analyzing the level of evidence were the purposes of this integrative literature review, carried out based on the databases LILACS, MEDLINE and PubMed, from 2005 to July 2012. Twenty articles were identified, in that, 12 literature reviews, 4 descriptive and exploratory studies, 2 expert opinions, one prospective cohort study and one was an experience report. The vesical intra-abdominal pressure measurement was considered gold standard. There are variations in the technique however, but some common points were identified: complete supine position, in absence of abdominal contracture, in the end of expiration and expressed in mmHg. Most research results indicate keeping the transducer zeroed at the level of the mid-axillary line at the iliac crest level, and instill 25mL of sterile saline. Strong evidence must be developed. RESUMO Em pacientes críticos com quadros abdominais agudos a esclarecer é crescente a solicitação da aferição da pressão intra-abdominal. Sintetizar resultados de pesquisas sobre a mensuração da pressão intra-abdominal pela via vesical e analisar o nível de evidência foram os objetivos desta revisão integrativa da literatura, realizada nas bases LILACS, MEDLINE e PubMed, no período de 2005 a julho de 2012. Identificaram-se 20 artigos, sendo 12 revisões de literatura, 4 estudos exploratório-descritivos, 2 opiniões de especialistas, 1 estudo de coorte prospectivo e 1 relato de experiência. O método vesical para mensuração da pressão intra-abdominal foi considerado padrão-ouro. Existem variações na técnica, entretanto pontos em comum foram identificados: posição supina completa, na ausência de contratura abdominal, ao final da expiração e expressa em mmHg. A maioria indica posicionar o ponto zero do

  16. Recogida de urocultivo por sondaje vesical en niños: una observación sistemática/Coleta de urocultura por sonda vesical em criança: uma observação sistemática/Collect of uroculture by urinary catheter in child: a systematic observation

    National Research Council Canada - National Science Library

    Guimarães, Marcelle Sampaio de Freitas

    2015-01-01

    ... evaluativo, prospectivo y cuantitativo, tiene por objeto comparar los resultados de los urocultivos por sondaje vesical recogidos por enfermeras del Ambulatorio y Enfermería de un Hospital Universitario Pediátrico teniendo en cuenta el material y la técnica utilizada en el procedimiento.La población de estudio consistió en 12 enfermeros, 4 ...

  17. La ecografía Doppler en la detección de invasión vesical en la placenta percreta: nuestra experiencia

    OpenAIRE

    P. García Saraví; N.K. Patiño; M.L. Juana; J. Mariano; E. Reyna; R. Tizzano

    2014-01-01

    Objetivo: Demostrar la utilidad de la ecografía Doppler en la detección de la invasión vesical en el percretismo placentario. Materiales y métodos: Se evaluó por ecografía, desde noviembre de 2011 hasta mayo de 2013, a 21 pacientes de entre 20 y 44 años que tenían diagnóstico quirúrgico e histopatológico de acretismo placentario (AP). Se consideró invasión vesical a la presencia de estructuras vasculares parietales en la evaluación Doppler color, mientras que se estableció como probable...

  18. Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

    Science.gov (United States)

    Black, Adrienne T; Hayden, Patrick J; Casillas, Robert P; Heck, Diane E; Gerecke, Donald R; Sinko, Patrick J; Laskin, Debra L; Laskin, Jeffrey D

    2010-12-01

    Sulfur mustard is a potent vesicant that induces inflammation, edema and blistering following dermal exposure. To assess molecular mechanisms mediating these responses, we analyzed the effects of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide, on EpiDerm-FT™, a commercially available full-thickness human skin equivalent. CEES (100-1000 μM) caused a concentration-dependent increase in pyknotic nuclei and vacuolization in basal keratinocytes; at high concentrations (300-1000 μM), CEES also disrupted keratin filament architecture in the stratum corneum. This was associated with time-dependent increases in expression of proliferating cell nuclear antigen, a marker of cell proliferation, and poly(ADP-ribose) polymerase (PARP) and phosphorylated histone H2AX, markers of DNA damage. Concentration- and time-dependent increases in mRNA and protein expression of eicosanoid biosynthetic enzymes including COX-2, 5-lipoxygenase, microsomal PGE₂ synthases, leukotriene (LT) A₄ hydrolase and LTC₄ synthase were observed in CEES-treated skin equivalents, as well as in antioxidant enzymes, glutathione S-transferases A1-2 (GSTA1-2), GSTA3 and GSTA4. These data demonstrate that CEES induces rapid cellular damage, cytotoxicity and inflammation in full-thickness skin equivalents. These effects are similar to human responses to vesicants in vivo and suggest that the full thickness skin equivalent is a useful in vitro model to characterize the biological effects of mustards and to develop potential therapeutics. Copyright © 2010 Elsevier Inc. All rights reserved.

  19. Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species.

    Science.gov (United States)

    Gray, Joshua P; Mishin, Vladimir; Heck, Diane E; Laskin, Debra L; Laskin, Jeffrey D

    2010-09-01

    Inhalation of vesicants including sulfur mustard can cause significant damage to the upper airways. This is the result of vesicant-induced modifications of proteins important in maintaining the integrity of the lung. Cytochrome P450s are the major enzymes in the lung mediating detoxification of sulfur mustard and its metabolites. NADPH cytochrome P450 reductase is a flavin-containing electron donor for cytochrome P450. The present studies demonstrate that the sulfur mustard analog, 2-chloroethyl ethyl sulfide (CEES), is a potent inhibitor of human recombinant cytochrome P450 reductase, as well as native cytochrome P450 reductase from liver microsomes of saline and beta-naphthoflavone-treated rats, and cytochrome P450 reductase from type II lung epithelial cells. Using rat liver microsomes from beta-naphthoflavone-treated rats, CEES was found to inhibit CYP 1A1 activity. This inhibition was overcome by microsomal cytochrome P450 reductase from saline-treated rats, which lack CYP 1A1 activity, demonstrating that the CEES inhibitory activity was selective for cytochrome P450 reductase. Cytochrome P450 reductase also generates reactive oxygen species (ROS) via oxidation of NADPH. In contrast to its inhibitory effects on the reduction of cytochrome c and CYP1A1 activity, CEES was found to stimulate ROS formation. Taken together, these data demonstrate that sulfur mustard vesicants target cytochrome P450 reductase and that this effect may be an important mechanism mediating oxidative stress and lung injury. 2010. Published by Elsevier Inc.

  20. Development of pre-activated α-cyclodextrin as a mucoadhesive excipient for intra-vesical drug delivery.

    Science.gov (United States)

    Ijaz, Muhammad; Prantl, Maximilian; Lupo, Noemi; Laffleur, Flavia; Hussain Asim, Mulazim; Matuszczak, Barbara; Bernkop-Schnürch, Andreas

    2017-12-20

    The study was designed to synthesize and characterize pre-activated α-cyclodextrin (α-CD) derivatives as mucus adhering excipients for intra-vesical drug delivery. Sodium periodate (NaIO4) was used to oxidize α-CD and subsequently cysteamine was covalently attached to carbonyl groups of oxidized α-CD via reductive amination to produce thiolated α-CD. l-cysteine-2-mercaptonicotinic acid conjugate (Cys-MNA) was covalently attached to carbonyl groups of oxidized α-CD to produce pre-activated α-CD having enhance stability against oxidation at higher pH. Thiolated and pre-activated α-CD derivatives were quantitatively assayed for the attached thiol groups and MNA groups, respectively. Cell viability and tolerability was evaluated via resazurin assay and via red blood cells (RBC) lysis assay, respectively. Mucoadhesive properties were evaluated on porcine bladder mucosa. Trimethoprim (TMP) was encapsulated into thiolated and pre-activated α-CD derivatives and the dissolution behavior was evaluated in vitro. Thiol groups attached to thiolated α-CD derivatives α-CD-SH780 and α-CD-SH1426 were 780±68μmol/g and 1426±66μmol/g, respectively. For the entirely pre-activated α-CD derivatives, α-CD-MNA3609 and α-CD-MNA4285 number of attached MNA groups were 3609±19μmol/g and 4285±43μmol/g, respectively. Thiolated and pre-activated derivatives of α-CD did not show adverse effects to cells determined via resazurin and RBC lysis assays. Mucoadhesion on porcine bladder mucosa was significantly improved for thiolated and pre-activated α-CD derivatives. Thiolated α-CD-SH1426 showed 15-fold and pre-activated α-CD-MNA4285 showed 25-fold improved mucoadhesion compared to unmodified α-CD. Further, pre-activated α-CD-MNA4285 showed 2-fold enhanced dissolution of encapsulated TMP compared to free TMP over 3 h. The study shows that pre-activated α-CD could be an excipient of the choice for the formulations of mucoadhesive intra-vesical drug delivery systems

  1. Eversión vesical completa a través de una fístula vesicovaginal

    Directory of Open Access Journals (Sweden)

    Jhoan Aragón Charry

    2013-05-01

    Full Text Available La eversión vesical completa es rara. Se presenta el caso de una eversión de vejiga urinaria a través de una fístula vesicovaginal acompañada de prolapso útero-vaginal concurrente. Se trata de paciente de 70 años que presentó una tumoración compatible con un prolapso vaginal grado IV y una tumoración edematosa, pegajosa y piriforme por delante del prolapso compatible con la vejiga con un orificio en la pared anterior de la vagina a través del cual la mucosa de la vejiga estaba evertida, procediendo al reposicionamiento y corrección manual de la eversión para luego ser corregida quirúrgicamente. Complete bladder eversion through vesicovaginal fistula Abstract Complete bladder eversion is rare. A case of bladder eversion trough vesicovaginal fistula accompanied with concomitant uterovaginal prolapse is presented. A 70 year-old patients presented a tumor compatible with vaginal prolapse type IV and an edematous, sticky and piriform tumor ahead of prolapse compatible with bladder with an orifice on anterior wall of vagina through bladder mucosa was everted, proceeding to reduction and manual correction of eversion and then was surgical corrected.

  2. A case of rectovagino-vesical fistula due to radiation therapy for uterine cancer treated with covered expandable metallic stent

    Energy Technology Data Exchange (ETDEWEB)

    Ohtsukasa, Shunroh; Okabe, Satoshi; Tanami, Hideaki [Tokyo Medical and Dental Univ. (Japan). School of Medicine] (and others)

    2002-04-01

    A 65-year-old woman had received a panhysterectomy and radiation therapy for a uterine cancer in 1974 and underwent a drainage operation for a peritonitis due to rupture of the bladder associated with radiation cystitis in 1983. A rectovesical fistula was revealed and partial resection of the bladder and rectum was performed in 1996. In 1998, rectovesical fistula recurred and symptom of fecaluria and contact-type dermatitis at perineal region subsequently worsened. In February, 2000, colonoscopy and gastrograffin-enema revealed a giant recto-vagino-vesical fistula. Although we recommended ileostomy, the patient refused our offer. She gave informed consent to our proposal about the insertion of a covered expandable metallic stent (EMS) into the rectum to treat for fecaluria. After insertion of a covered EMS, fecaluria and contact-type dermatitis at perineal region subsequently improved. Three months later, fecaluria appeared again. Finally, seven months later, severe inflammation occurred at perineal and pubic region because of migration of the covered EMS into the bladder, then we removed the covered EMS and performed ileostomy. It is difficult to use the covered EMS treatment for benign rectovesical or rectovaginal fistula for a long term. (author)

  3. Projections from bed nuclei of the stria terminalis, magnocellular nucleus: implications for cerebral hemisphere regulation of micturition, defecation, and penile erection.

    Science.gov (United States)

    Dong, Hong-Wei; Swanson, Larry W

    2006-01-01

    The basic structural organization of axonal projections from the small but distinct magnocellular and ventral nuclei (of the bed nuclei of the stria terminalis) was analyzed with the Phaseolus vulgaris leucoagglutinin anterograde tract tracing method in adult male rats. The former's overall projection pattern is complex, with over 80 distinct terminal fields ipsilateral to injection sites. Innervated regions in the cerebral hemisphere and brainstem fall into nine general functional categories: cerebral nuclei, behavior control column, orofacial motor-related, humorosensory/thirst-related, brainstem autonomic control network, neuroendocrine, hypothalamic visceromotor pattern-generator network, thalamocortical feedback loops, and behavioral state control. The most novel findings indicate that the magnocellular nucleus projects to virtually all known major parts of the brain network that controls pelvic functions, including micturition, defecation, and penile erection, as well as to brain networks controlling nutrient and body water homeostasis. This and other evidence suggests that the magnocellular nucleus is part of a corticostriatopallidal differentiation modulating and coordinating pelvic functions with the maintenance of nutrient and body water homeostasis. Projections of the ventral nucleus are a subset of those generated by the magnocellular nucleus, with the obvious difference that the ventral nucleus does not project detectably to Barrington's nucleus, the subfornical organ, the median preoptic and parastrial nuclei, the neuroendocrine system, and midbrain orofacial motor-related regions.

  4. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning.

    Science.gov (United States)

    Sunil, Vasanthi R; Shen, Jianliang; Patel-Vayas, Kinal; Gow, Andrew J; Laskin, Jeffrey D; Laskin, Debra L

    2012-05-15

    Pulmonary toxicity induced by sulfur mustard and related vesicants is associated with oxidative stress. In the present studies we analyzed the role of reactive nitrogen species (RNS) generated via inducible nitric oxide synthase (iNOS) in lung injury and inflammation induced by vesicants using 2-chloroethyl ethyl sulfide (CEES) as a model. C57Bl/6 (WT) and iNOS-/- mice were sacrificed 3 days or 14 days following intratracheal administration of CEES (6 mg/kg) or control. CEES intoxication resulted in transient (3 days) increases in bronchoalveolar lavage (BAL) cell and protein content in WT, but not iNOS-/- mice. This correlated with expression of Ym1, a marker of oxidative stress in alveolar macrophages and epithelial cells. In contrast, in iNOS-/- mice, Ym1 was only observed 14 days post-exposure in enlarged alveolar macrophages, suggesting that they are alternatively activated. This is supported by findings that lung tumor necrosis factor and lipocalin Lcn2 expression, mediators involved in tissue repair were also upregulated at this time in iNOS-/- mice. Conversely, CEES-induced increases in the proinflammatory genes, monocyte chemotactic protein-1 and cyclooxygenase-2, were abrogated in iNOS-/- mice. In WT mice, CEES treatment also resulted in increases in total lung resistance and decreases in compliance in response to methacholine, effects blunted by loss of iNOS. These data demonstrate that RNS, generated via iNOS play a role in the pathogenic responses to CEES, augmenting oxidative stress and inflammation and suppressing tissue repair. Elucidating inflammatory mechanisms mediating vesicant-induced lung injury is key to the development of therapeutics to treat mustard poisoning. Copyright © 2012 Elsevier Inc. All rights reserved.

  5. Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning

    Energy Technology Data Exchange (ETDEWEB)

    Sunil, Vasanthi R., E-mail: sunilvr@eohsi.rutgers.edu [Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy Piscataway, NJ (United States); Shen, Jianliang; Patel-Vayas, Kinal; Gow, Andrew J. [Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy Piscataway, NJ (United States); Laskin, Jeffrey D. [Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ (United States); Laskin, Debra L. [Department of Pharmacology and Toxicology, Rutgers University, Ernest Mario School of Pharmacy Piscataway, NJ (United States)

    2012-05-15

    Pulmonary toxicity induced by sulfur mustard and related vesicants is associated with oxidative stress. In the present studies we analyzed the role of reactive nitrogen species (RNS) generated via inducible nitric oxide synthase (iNOS) in lung injury and inflammation induced by vesicants using 2-chloroethyl ethyl sulfide (CEES) as a model. C57Bl/6 (WT) and iNOS −/− mice were sacrificed 3 days or 14 days following intratracheal administration of CEES (6 mg/kg) or control. CEES intoxication resulted in transient (3 days) increases in bronchoalveolar lavage (BAL) cell and protein content in WT, but not iNOS −/− mice. This correlated with expression of Ym1, a marker of oxidative stress in alveolar macrophages and epithelial cells. In contrast, in iNOS −/− mice, Ym1 was only observed 14 days post-exposure in enlarged alveolar macrophages, suggesting that they are alternatively activated. This is supported by findings that lung tumor necrosis factor and lipocalin Lcn2 expression, mediators involved in tissue repair were also upregulated at this time in iNOS −/− mice. Conversely, CEES-induced increases in the proinflammatory genes, monocyte chemotactic protein-1 and cyclooxygenase-2, were abrogated in iNOS −/− mice. In WT mice, CEES treatment also resulted in increases in total lung resistance and decreases in compliance in response to methacholine, effects blunted by loss of iNOS. These data demonstrate that RNS, generated via iNOS play a role in the pathogenic responses to CEES, augmenting oxidative stress and inflammation and suppressing tissue repair. Elucidating inflammatory mechanisms mediating vesicant-induced lung injury is key to the development of therapeutics to treat mustard poisoning. -- Highlights: ► Lung injury, inflammation and oxidative stress are induced by the model vesicant CEES ► RNS generated via iNOS are important in the CEES-induced pulmonary toxicity ► iNOS −/− mice are protected from CEES-induced lung toxicity and

  6. Bicycling induced pudendal nerve pressure neuropathy.

    Science.gov (United States)

    Silbert, P L; Dunne, J W; Edis, R H; Stewart-Wynne, E G

    1991-01-01

    Pudendal neuropathies are well recognised as part of more generalised peripheral neuropathies; however, focal abnormalities of the pudendal nerve due to cycling-related injuries have been infrequently reported. We describe two patients who developed pudendal neuropathies secondary to pressure effects on the perineum from racing-bicycle saddles. Both were male competitive athletes, one of whom developed recurrent numbness of the penis and scrotum after prolonged cycling; the other developed numbness of the penis, an altered sensation of ejaculation, with disturbance of micturition and reduced awareness of defecation. Both patients improved with alterations in saddle position and riding techniques. We conclude that pudendal nerve pressure neuropathy can result from prolonged cycling, particularly when using a poor riding technique.

  7. Litiasis vesical por cuerpo extraño en vejiga. Presentación de un caso clínico.

    Directory of Open Access Journals (Sweden)

    Norys Sofía Aguiar Rodríguez

    2013-01-01

    Full Text Available La litiasis vesical es una patología frecuente en el sexo masculino mayor de 50 años. Los cálculos vesicales en la mujer son muy raros y usualmente están asociados a divertículo uretral o a ureterocele (7,8 dentro de las causas de litiasis vesical está la presencia de cuerpos extraños, como en el caso de mujeres operadas de incontinencia urinaria y la formación de litiasis a partir de restos de suturas, es importante sospechar la presencia de cuerpo extraño en la vejiga ante una paciente en edad fértil, con disuria y sepsis urinaria a repetición. Se presenta un caso clínico de una mujer con sepsis urinaria rebelde a tratamiento y disuria mantenida. Se diagnostica por cistoscopía la presencia de una litiasis urinaria en vejiga, es intervenida quirúrgicamente encontrándose una litiasis a partir de una guía de un Dispositivo Intrauterino (DIU que perforó la vejiga.

  8. Infecção do trato urinário relacionada ao cateter vesical de demora: incidência e fatores de risco

    Directory of Open Access Journals (Sweden)

    Stamm A.M.N. de F.

    1999-01-01

    Full Text Available OBJETIVO: Determinar a incidência e os fatores de risco relacionados a infecção do trato urinário (ITU em pacientes submetidos à sondagem vesical de demora (SVD. MÉTODOS E CASUÍSTICA: Cento e trinta e seis pacientes submetidos à SVD entre maio e dezembro de 1993 no Hospital Universitário(HU da Universidade Federal de Santa Catarina (UFSC. Estudo observacional de coorte contemporânea, não-controlado, em pacientes submetidos a SVD, que foram seguidos desde a inserção até a remoção da sonda. Culturas de urina no ato da inserção e da retirada foram realizadas em meios convencionais para bactérias aeróbicas; também foi cultivado material obtido com "swab" do meato uretral. Na análise estatística usou-se métodos paramétricos para variáveis categóricas e contínuas, e análise multivariada para determinação de fatores de risco para ITU. RESULTADOS: A incidência de ITU associada a SVD nesta amostra foi de 11 % . Na análise univariada três fatores foram significativos estatisticamente: a doença de base (clínica ou cirúrgica (p=0,01, a permanência em uma clínica durante a internação(p=0,02 e a duração (em dias da cateterização (p= 0,00003 Na análise multivariada, somente a duração da sondagem vesical foi preditiva para ITU (p = 0,03. CONCLUSÕES: A incidência de ITU relacionada a SVD na amostra analisada foi de 11,0%, porque no HU da UFSC existe um controle dos fatores de risco alteráveis. A duração da sondagem vesical é um importante fator de risco para este problema. Recomenda-se limitar ao mínimo necessário o tempo de cateterização em pacientes internados.

  9. Giant vesical calculus

    African Journals Online (AJOL)

    Foley carheter inserted for continuous bladder drainage. Postoperative course. A continuous keramine infusion was given for 24 hours as rhe only analgesic. Intravenous gentamicin and rerracycline were given for 7days. A fluid intake and ourpur chart was maintained; urinary excrerion increased rapidly and was normal by ...

  10. Comportamiento de los marcadores de estrés oxidativo en la orina de pacientes con tumor vesical no músculo invasivo.

    OpenAIRE

    Hernández Medina, José Alberto

    2015-01-01

    El carcinoma urotelial de vejiga constituye el tumor más frecuente del tracto urinario, siendo el séptimo cáncer más frecuente en varones, el decimoséptimo en mujeres y la octava causa de mortalidad cáncer específica en Europa. La clínica más habitual de presentación es la hematuria monosintomática, siendo otros síntomas posibles el tenesmo, disuria, polaquiuria y dolor pélvico. El diagnóstico y seguimiento del tumor vesical se basa en pruebas de imagen (principalmente ecografía y TAC) y, de...

  11. Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

    Science.gov (United States)

    Sunil, Vasanthi R; Patel-Vayas, Kinal; Shen, Jianliang; Gow, Andrew J; Laskin, Jeffrey D; Laskin, Debra L

    2011-02-01

    Lung toxicity induced by sulfur mustard is associated with inflammation and oxidative stress. To elucidate mechanisms mediating pulmonary damage, we used 2-chloroethyl ethyl sulfide (CEES), a model sulfur mustard vesicant. Male mice (B6129) were treated intratracheally with CEES (3 or 6 mg/kg) or control. Animals were sacrificed 3, 7 or 14 days later and bronchoalveolar lavage (BAL) fluid and lung tissue collected. Treatment of mice with CEES resulted in an increase in BAL protein, an indication of alveolar epithelial damage, within 3 days. Expression of Ym1, an oxidative stress marker also increased in the lung, along with inducible nitric oxide synthase, and at 14 days, cyclooxygenase-2 and monocyte chemotactic protein-1, inflammatory proteins implicated in tissue injury. These responses were attenuated in mice lacking the p55 receptor for TNFα (TNFR1-/-), demonstrating that signaling via TNFR1 is key to CEES-induced injury, oxidative stress, and inflammation. CEES-induced upregulation of CuZn-superoxide dismutase (SOD) and MnSOD was delayed or absent in TNFR1-/- mice, relative to WT mice, suggesting that TNFα mediates early antioxidant responses to lung toxicants. Treatment of WT mice with CEES also resulted in functional alterations in the lung including decreases in compliance and increases in elastance. Additionally, methacholine-induced alterations in total lung resistance and central airway resistance were dampened by CEES. Loss of TNFR1 resulted in blunted functional responses to CEES. These effects were most notable in the airways. These data suggest that targeting TNFα signaling may be useful in mitigating lung injury, inflammation and functional alterations induced by vesicants. Copyright © 2010 Elsevier Inc. All rights reserved.

  12. Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide.

    Science.gov (United States)

    Black, Adrienne T; Hayden, Patrick J; Casillas, Robert P; Heck, Diane E; Gerecke, Donald R; Sinko, Patrick J; Laskin, Debra L; Laskin, Jeffrey D

    2011-06-01

    Dermal exposure to the vesicant sulfur mustard causes marked inflammation and tissue damage. Basal keratinocytes appear to be a major target of sulfur mustard. In the present studies, mechanisms mediating skin toxicity were examined using a mouse skin construct model and a full-thickness human skin equivalent (EpiDerm-FT™). In both systems, administration of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide (CEES, 100-1000μM) at the air surface induced mRNA and protein expression of heat shock proteins 27 and 70 (Hsp27 and Hsp70). CEES treatment also resulted in increased expression of caveolin-1, the major structural component of caveolae. Immunohistochemistry revealed that Hsp27, Hsp70 and caveolin-1 were localized in basal and suprabasal layers of the epidermis. Caveolin-1 was also detected in fibroblasts in the dermal component of the full thickness human skin equivalent. Western blot analysis of caveolar membrane fractions isolated by sucrose density centrifugation demonstrated that Hsp27 and Hsp70 were localized in caveolae. Treatment of mouse keratinocytes with filipin III or methyl-β-cyclodextrin, which disrupt caveolar structure, markedly suppressed CEES-induced Hsp27 and Hsp70 mRNA and protein expression. CEES treatment is known to activate JNK and p38 MAP kinases; in mouse keratinocytes, inhibition of these enzymes suppressed CEES-induced expression of Hsp27 and Hsp70. These data suggest that MAP kinases regulate Hsp 27 and Hsp70; moreover, caveolae-mediated regulation of heat shock protein expression may be important in the pathophysiology of vesicant-induced skin toxicity. Copyright © 2011 Elsevier Inc. All rights reserved.

  13. Alkalinized lidocaine versus lidocaine gel as local anesthesia prior to intra-vesical botulinum toxin (BoNTA) injections: A prospective, single center, randomized, double-blind, parallel group trial of efficacy and morbidity.

    Science.gov (United States)

    Nambiar, Arjun K; Younis, Ayman; Khan, Zainab A; Hildrup, Iona; Emery, Simon J; Lucas, Malcolm G

    2016-04-01

    To assess the efficacy and morbidity of alkalinized lidocaine solution compared to lidocaine gel for intra-vesical anesthesia during botulinum toxin (BoNTA) injections in a statistically powered, prospective, parallel group, double-blind randomized controlled trial. Fifty-four patients of either sex were randomized to receive either alkalinized lidocaine (AL) solution (10 ml 8.4% sodium bicarbonate + 20 ml 2% lidocaine solution + 22 ml sterile Aquagel®) or lidocaine gel (LG) (22 ml standard 2% lidocaine gel Instillagel® + 30 ml 0.9% normal saline solution). Primary outcome was average pain (assessed by 100 mm visual analog score) felt during intra-vesical BoNTA injections performed at least 20 min after instillation. Secondary outcome was the rate of adverse events. Of 60 randomized patients 54 received the allocated intervention and were analyzed. Mean pain score in the AL group was 17.11 mm (95%CI 8.65-25.57 mm) and in the LG group was 19.53 mm (95%CI 13.03-26.03mm) with no significant difference between the groups. Cost of interventional medication in the AL group was almost double that of the LG group. No adverse events were attributable to local anesthetic instillation in either group. Alkalinized lidocaine solution is not superior to lidocaine gel for anesthesia during intra-vesical BoNTA injections, and the higher cost precludes its use over lidocaine gel at our centre. We have used the results of this study to adapt our local protocol for BoNTA injections and continue to use lidocaine gel as the local anesthetic of choice. Neurourol. Urodynam. 35:522-527, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  14. Relación del residuo post-miccional, grado de "trabeculación" vesical y el flujo urinario en pacientes con hiperplasia prostática benigna sintomática.

    Directory of Open Access Journals (Sweden)

    Humberto Condori

    2012-07-01

    Full Text Available Objetivo: Determinar la relación entre el grado de "trabeculación" vesical, el residuo pos miccional y el grado de obstrucción al flujo de salida urinario en pacientes con hiperplasia benigna de próstata (HBP sintomática. Material y métodos: Serie de casos analítico y retrospectivo que incluyó 37 pacientes con HBP sintomática atendidos ambulatoriamente en el servicio de Urología del Hospital Nacional Cayetano Heredia en el 2009. El grado de "trabeculación" vesical se determinó por cistoscopia, el residuo vesical post-miccional por ecografía y el grado de obstrucción mediante uroflujometría. Resultados: La edad de los pacientes fue: 68,2 ± 7,9 (50-83 años. Los valores del volumen prostático, porcentaje de residuo post-miccional y el flujo máximo fueron: 46,4 ± 20,6 cc (20-113; 33,4% ± 20,7 (5- 80 y 6,7 ± 2,12 7 ml/seg (3-10, respectivamente. No se encontró correlación entre: el porcentaje de residuo post-miccional y el flujo urinario máximo (rs = -0,07; p=0,67 y entre el volumen prostático y el flujo máximo con (rs= 0,05; p= 0,7. Tampoco se encontró concordancia entre el grado de "trabeculación" vesical y el flujo máximo (Kappa= 0,0034; p=0,5 y entre el porcentaje de residuo post-miccional y el grado de "trabeculación" (Kappa= 0,18; p=0,06. Conclusión: No se encontró relación entre el flujo máximo urinario, el porcentaje de residuo post-miccional y el grado de "trabeculación", en pacientes con HBP sintomática.

  15. Influence of nicotine on healing of vesical sutures in rabbits A influência da nicotina na cicatrização de suturas vesicais em coelhos

    Directory of Open Access Journals (Sweden)

    Christiano Machado

    2007-12-01

    Full Text Available PURPOSE: To study the effects of nicotine on inflammatory cells, deposition of collagen and its interference on the strength of tissue in vesical sutures in rabbits. METHODS: Twenty New Zealand rabbits were used, randomized into two groups: group N, consisting of 10 animals, to which nicotine was administered in the dose of 2mg/kg of weight as a subcutaneous injection, diluted in 1ml of saline solution at 0.9% in a daily administration during the 28 days prior to the surgery; and group C, consisting of 10 animals, to which saline solution at 0.9% was administered in the same conditions and time intervals of the nicotine group. All the animals underwent cystotomy and suture of the bladder wall 28 days after the administration of nicotine or saline solution. The measurements were performed on the fourth and seventh day in each group after cystectomy and euthanasia of the animals. A fragment of bladder was removed and sent for a tensile strength test to evaluate the tissue strength and another fragment underwent a histological analysis of inflammatory process and deposition of collagen. RESULTS: There was a decrease of neutrophils on the fourth postoperative day (p=0.079 and an increase of plasmocytes on the seventh postoperative day (p=0.053 in the animals that were given nicotine, without statistical difference in relation to the control group. In the analysis of the proliferation of fibroblasts, deposition of collagen and tensile strength test, there was no statistical difference in relation to the control group. CONCLUSION: The administration of nicotine in rabbits did not influence the healing process of vesical suture in relation to the inflammatory cells, deposit of collagen and tissue strength of the suture.OBJETIVO: Estudar os efeitos da nicotina sobre as células inflamatórias, deposição de colágeno e sua interferência sobre a força tecidual em suturas vesicais de coelhos. MÉTODOS: Foram utilizados 20 coelhos Nova Zel

  16. Diagnóstico y tratamiento de la esquistosomiasis vesical desde la atención primaria penitenciaria: a propósito de un caso Diagnosis and treatment of bladder schistosomiasis from penitentiary primary care: case report

    Directory of Open Access Journals (Sweden)

    A. Bedoya del Campillo

    2012-10-01

    Full Text Available Se describe un caso clínico de un paciente procedente de Senegal con síndrome miccional y hematuria microscópica que fue diagnosticado y tratado de esquistosomiasis vesical en los servicios médicos del Centro Penitenciario de Jóvenes de Barcelona. Según nuestra información en la base de datos Medline no existen casos de esquistosomiasis vesical abordados en atención primaria fuera de áreas endémicas. Los pacientes pueden diagnosticarse y tratarse antes de ser derivados a la asistencia especializada para continuar estudio de posibles complicaciones.We describe a case of a patient from Senegal with voiding symptoms and microscopic hematuria diagnosed and treated for bladder schistosomiasis in the medical services of the Youth Prison in Barcelona. According to our information in the Medline database no bladder schistosomiasis cases have been seen in primary care outside endemic areas. Patients can be diagnosed andtreated before referral to specialized care for further study of possible complications.

  17. Ação do citrato de sildenafil sobre a função uretral de ratas com desnervação vesical Effect of sildenafil citrate in the urethral function in rats with denervated bladder

    Directory of Open Access Journals (Sweden)

    Haylton Jorge Suaid

    2003-01-01

    urethane at a dosage of 1.25mg/kg. All animals underwent cystostomy with a catheter P50 connected by a Y to an infusion pump and to a polygraph Narco-Biosystem. The cystometry was performed trice in each animal: right after the cystostomy, after surgical of bladder denervation and 1h after gastric infusion of 1mg/kg of sildenafil citrate. Maximum (MaP and minimum (MiP vesical pressure were compared in the following moments: I - before bladder denervation, II - after bladder denervation and III - after bladder denervation and sildenafil administration. Wilcoxon test was used for a level of significance of 5%. RESULTS: Mean values of MaP were: I - 86.6±10.1, II - 42.6±15.0 and III - 30.8±12.4. The corresponding values of MiP were: : I - 72.1±18.9, II - 31.1±9.8 and III - 14.5±9.5. The comparison between MaP and MiP in each moment showed difference only in moment III (p0.05 in IIxIII. For MiP the p values were <0.004 in IxII, <0.002 in IxIII and <0.01 in IIxIII. CONCLUSION: 1 Bladder denervation reduces maximum and minimum urethral pressure; 2 Sildenafil citrate reduces the minimum urethral pressure widening the interval between the peak and bottom pressures; and, 3 Sildenafil citrate does not interfere on the peak urethral pressure after bladder denervation.

  18. Fatores associados à bacteriúria após sondagem vesical na cirurgia ginecológica Factors associated with bacteriuria after indwelling urethral catheterization in gynecologic surgery

    Directory of Open Access Journals (Sweden)

    Sonia Cristina Araújo Hinrichsen

    2009-01-01

    Full Text Available OBJETIVOS: Determinar a frequência e os principais fatores associados à bacteriúria após a sondagem vesical em mulheres submetidas à cirurgia ginecológica eletiva. MÉTODOS: Realizou-se um estudo do tipo coorte em mulheres submetidas à cirurgia ginecológica após sondagem vesical no Instituto de Medicina Integral Prof. Fernando Figueira, no período de janeiro a maio de 2007. As uroculturas foram coletadas até 24 horas após a retirada da sonda e 7/10 dias após a sondagem vesical. A análise estatística bivariada e multivariada foi realizada calculando-se a razão de risco e os seus intervalos de confiança a 95%. RESULTADOS: Foram incluídas no estudo 249 mulheres. A frequência de uroculturas positivas até 24 horas depois da retirada da sonda foi de 23,6%, diminuindo para 11,1% 7/10 dias após a sondagem. Destas, apenas 2,4% eram sintomáticas. Verificou-se menor risco de bacteriúria com 7/10 dias após a sondagem vesical quando a paciente referiu vulvovaginite tratada nos últimos três meses, não permanecendo estatisticamente significativa após a análise multivariada. Não houve associação significativa com idade, escolaridade, número de gestações, paridade, fase da vida reprodutiva, tipo e duração da cirurgia, tipo da anestesia, uso de antibiótico profilático, profissional que colocou a sonda e o tempo de permanência da sonda vesical. CONCLUSÃO: A frequência de bacteriúria foi de 23,6% e 11,1% com 24 horas e 7/10 dias, respectivamente. Não se encontrou associação significativa das variáveis pesquisadas com a bacteriúria evidenciada na urocultura com 7/10 dias.OBJECTIVES: To determine the frequency and risk factors associated to bacteriuria after urinary catheterization in women submitted to elective gynecological surgery. METHODS: A cohort study was carried out among women submitted to gynecological surgery after urinary catheterization. This study took place at the "Instituto de Medicina Integral Professor

  19. Tissue Engineering in Vesical Reconstruction

    African Journals Online (AJOL)

    mn

    specimen that initially covered a surface area of 1cm2, to one covering a surface area of. 4202 m2 within 8 weeks (the equivalent of one football field). These studies indicated that it should be possible to collect autologous .... Food and Drug Administration. A clinical trial in patients with bladder cancer requiring.

  20. Perfil dos microrganismos isolados no trato urinário após sondagem vesical em cirurgia ginecológica Profile of microorganisms found in urocultures after urinary catheterization in patients undergoing elective gynecological surgery

    Directory of Open Access Journals (Sweden)

    Sônia Cristina Hinrichsen

    2009-03-01

    Full Text Available OBJETIVOS: determinar os microrganismosfreqüentemente encontrados nas uroculturas apóssondagem vesical e o perfil de sensibilidade aos antibióticos em mulheres submetidas a cirurgia ginecológica eletiva. MÉTODOS: estudo de corte transversal em mulheres submetidas a cirurgia ginecológica com sondagem vesical, no Instituto de Medicina Integral Professor Fernando Figueira (IMIP, em Recife, Pernambuco, Brasil, de janeiro a maio de 2007. As uroculturas foram coletadas em dois períodos: até 24h da retirada do cateter e após sete/10 dias. RESULTADOS: amostras de urina foram colhidas em 249 mulheres. Encontrouse 23,6% (n=46 de uroculturas positivas com até 24h da retirada da sonda e 11,1% (n=25 com sete/10 dias após sondagem vesical. Não foi observada diferença significativa em relação aos microrganismos, quando se compararamas duas uroculturas. A Klebsiella spp. foi o principal microrganismo em ambas uroculturas (até 24h=47,8% vs sete/10 dias=44,0%; p=0,76, seguido de Escherichia coli e outros Gram-negativos. Os antibióticos amicacina, cefepima, ciprofloxacina, meropenem e ticarcilina-clavulanato foram os que apresentaram sensibilidade igual ou superior a 75%para os principais microrganismos isolados. CONCLUSÕES: Klebsiella spp. foi o microrganismo mais encontrado nas uroculturas após sondagem vesical em cirurgias ginecológicas e o antibiótico com sensibilidade igual ou maior a 95% com via de administração oral foi a ciprofloxacina.OBJECTIVES: to determine the microorganisms mostfrequently found in urocultures after urinary catheterization and their antibiotic sensitivities in women undergoing elective gynecological surgery. METHODS: the study was carried out at theInstituto de Medicina Integral Professor FernandoFigueira, IMIP, in Recife, Pernambuco, Brazil, between January and May 2007. Urine cultures wereobtained from these patients on two occasions subsequent to the removal of the catheter: within the first 24h and 710 days

  1. Pressure ulcers

    National Research Council Canada - National Science Library

    Reddy, Madhuri

    2011-01-01

    Unrelieved pressure or friction of the skin, particularly over bony prominences, can lead to pressure ulcers in up to one third of people in hospitals or community care, and one fifth of nursing home residents...

  2. Barometric pressure

    Science.gov (United States)

    Billings, C. E.

    1973-01-01

    The effects of alterations in barometric pressure on human beings are described. Human tolerances for gaseous environments and low and high barometric pressure are discussed, including effects on specific areas, such as the ear, lungs, teeth, and sinuses. Problems due to trapped gas within the body, high dynamic pressures on the body, and blasts are also considered.

  3. Effect of nicotine on the pelvic afferent nerve activity and bladder pressure in rats.

    Science.gov (United States)

    Kontani, Hitoshi; Okamura, Takashi; Kimura, Satoko; Ishida, Kazuumi; Takeno, Satoshi

    2009-08-01

    To record afferent nerve activity and bladder pressure in anesthetized male rats and to investigate whether increased afferent nerve activity induced by nicotine is able to evoke reflex bladder contractions. Using continuous infusion cystometrography, bladder pressure was measured via a bladder cannula. Afferent activity was recorded in the uncut L6 dorsal root. Nicotine was injected intra-arterially through a cannula placed near the bifurcation of the internal iliac artery a few minutes after micturition. Nicotine (0.15-1.5 micromol) evoked a marked elevation of afferent discharge without a simultaneous increase in bladder pressure. Bladder contractions appeared about 43 and 19 s after bolus injection of nicotine at 0.45 and 1.5 micromol, respectively. Firing rates of afferent nerves were reduced when the contraction appeared. Continuous infusion of nicotine at 0.75 micromol/min for 20 min evoked marked elevation of afferent discharge, which was maintained during infusion of nicotine and after it had been withdrawn. Repetitive contractions were observed thereafter and disappeared when the L6 dorsal roots were bilaterally resected. A transient increase in afferent discharges induced by bolus injection of nicotine was unable to evoke reflex bladder contraction. Repetitive bladder contractions after withdrawal of continuous nicotine infusion were induced in a reflex manner by the increased afferent activity.

  4. Biofilme em cateter vesical de demora e a segurança do paciente: uma revisão da literatura | Biofilm in indwelling urinary catheter and patient safety: a literature review

    Directory of Open Access Journals (Sweden)

    Écila Campos Mota

    2017-08-01

    Full Text Available Introdução: A infecção do trato urinário associada a cateter vesical de demora (ITU-CVD representa cerca de 40,0% das infecções relacionadas à assistência à saúde (IRAS. Objetivo: Identificar através da literatura os principais fatores associados à formação do biofilme em cateter vesical de demora (CVD. Método: Revisão nas bases de dados: Lilacs, Ibecs PubMed e Portal Capes, utilizando os descritores: “infecção do trato urinário”; “cateteres urinários” e “biofilme” de artigos publicados na íntegra entre 2009 e 2016, nos idiomas inglês, espanhol ou português. Resultados: Foram selecionados oito artigos, sendo quatro revisões sistemáticas e quatro estudos observacionais. Os biofilmes nos CVD são formados pela fixação de patógenos que se inicia pela deposição de urina na superfície do cateter. Os fatores associados à formação do biofilme no CVD foram: tipo de microrganismos (87,5%, presença de flagelos, motilidade e produção de urease, conformação estrutural (37,5% em látex (superfícies irregulares hidrofóbicas e hidrofílicas que permitem a adesão e colonização por vários microrganismos, e o sexo feminino (12,5%. Conclusões: a presente revisão identificou os fatores associados à formação do biofilme no CVD e assim contribuiu para a proposição de medidas eficazes na prevenção com foco na segurança do paciente. ============================================= Introduction: Urinary tract infection associated with indwelling urinary catheter accounts for about 40.0% of health care-related infection. Objective: To identify, based on literature review, the factors associated with biofilm formation in an indwelling urinary catheter. Method: An integrative review conducted in the databases: Medline, Lilacs, IBECS, PubMed and Portal Capes, using the descriptors “urinary tract infections”, “urinary catheters” and “biofilm”, with articles published in full between 2009 and 2016 in

  5. Pressure sensor

    Science.gov (United States)

    Mee, David K.; Ripley, Edward B.; Nienstedt, Zachary C.; Nienstedt, Alex W.; Howell, Jr., Layton N.

    2015-09-29

    Disclosed is a passive, in-situ pressure sensor. The sensor includes a sensing element having a ferromagnetic metal and a tension inducing mechanism coupled to the ferromagnetic metal. The tension inducing mechanism is operable to change a tensile stress upon the ferromagnetic metal based on a change in pressure in the sensing element. Changes in pressure are detected based on changes in the magnetic switching characteristics of the ferromagnetic metal when subjected to an alternating magnetic field caused by the change in the tensile stress. The sensing element is embeddable in a closed system for detecting pressure changes without the need for any penetrations of the system for power or data acquisition by detecting changes in the magnetic switching characteristics of the ferromagnetic metal caused by the tensile stress.

  6. Blood pressure measurement

    Science.gov (United States)

    ... reading; Measuring blood pressure; Hypertension - blood pressure measurement; High blood pressure - blood pressure measurement ... High blood pressure has no symptoms so you may not know if you have this problem. High blood pressure ...

  7. Urethral catheter removal 7 or 14 days after radical retropubic prostatectomy: clinical implications and complications in a randomized study Sete ou quatorze dias para a retirada da sonda vesical de demora após prostatectomia radical retropúbica: implicações clínicas e complicações em um estudo randomizado

    Directory of Open Access Journals (Sweden)

    Carlos Ary Vargas Souto

    2004-01-01

    Full Text Available PURPOSE: To evaluate the hypothesis that a 7-day period of indwelling catheter after radical retropubic prostatectomy is effective and safe without the need of performing cystography. METHODS: In the period from January of 2000 to July of 2002, 73 patients underwent radical retropubic prostatectomy, and these patients were prospectively randomized in 2 groups: Group 1-37 patients who had the urethral catheter removed 7 days after the procedure, and Group 2-36 patients who had the catheter removed 14 days after the surgery. The 2 groups were similar, the surgeons and the technique were the same, and no cystography was performed to evaluate the presence of leaks. RESULTS: Two patients in Group 1 had bleeding and clot retention after having the catheter taken out in the seventh postoperative day and were managed by putting the catheter back in for 7 more days. Two patients in Group 2 developed bladder neck stricture and were treated by bladder neck incision with success. The continence rate was the same, with 2 cases of incontinence in each group. About 2 pads a day were used by the patients with incontinence. The average follow-up was 17.5 months (12-36 months. No urinary fistula, urinoma, or pelvic abscesses developed after catheter removal. Two patients were excluded from the analysis of this series: 1 died with a pulmonary embolus in the third postoperative day, and 1 developed a urinary suprapubic fistula before catheter withdrawal, which was maintained for 16 days. CONCLUSION: Withdrawal of the urethral catheter 7 days after radical retropubic prostatectomy, without performing cystography, has a low rate of short-term complications that are equivalent to withdrawal 14 days after the surgery.OBJETIVO: Avaliar a hipótese de que um período de sete dias de sonda vesical de demora após prostatectomia radical retropúbica é efetivo e seguro, sem a necessidade da realização de cistografia. MÉTODOS: Entre janeiro de 2000 e julho de 2002

  8. Tissue Engineering in Vesical Reconstruction | Morsi | African ...

    African Journals Online (AJOL)

    African Journal of Urology. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 16, No 1 (2010) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected should load here if your Web ...

  9. Tissue Engineering in Vesical Reconstruction | Morsi | African ...

    African Journals Online (AJOL)

    TE) and describes the possible future clinical application in bladder reconstruction. Material and Methods: This review is based on an electronic search of the PubMed database and recently published presentations between November 2008 and ...

  10. Vesicant Therapeutics Collaborative Core Research Program

    Science.gov (United States)

    2012-12-01

    Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202- 4302. Respondents...labeled nanoparticles by this administration route . There were plentiful nanoparticles found at or near the site of injection. We are trouble-shooting...enhancement properties of three grades of hyaluronic acid using porcine buccal and vaginal tissue, Caco-2 cell lines, and rat jejunum. The Journal of

  11. Proceedings of the Vesicant Workshop, February 1987

    Science.gov (United States)

    1987-12-01

    det.xification of mustard in vivo and have included sodium thiosulfate and Unithiol (2,3--imercapto- propane -l-sulfonate, DMPS) for the pretreatment and...always be a problem, and will require a careful matching of specific responses. For example, study of hypersensitivity to mustard should be conducted

  12. Megabladder in experimental Chagas disease: pathological features of the bladder wall Mega bexiga na Doença de Chagas experimental. Caracteristicas patológicas da parede vesical

    Directory of Open Access Journals (Sweden)

    Luciano Henrique Gazoni Scremin

    1999-04-01

    Full Text Available Mega-organs, primarily in the digestive tract, are well known to occur in chronic Chagas disease. Acute experimental infection with Trypanosoma cruzi results in parasitism of a wide range of cells, tissues, and organs, including the urinary bladder. Infection of BALB/c mice with 100,000 bloodstream forms of the Y strain of T. cruzi induced acute infection with intense parasitism of all layers of the urinary bladder. Parasites were found in the mucosa, lamina propria, muscular, adventitial connective, and fat tissue. Desquamate epithelial cells with amastigotes in the bladder lumen were also found. After 60 days of infection, mice inoculated with 50 bloodstream forms developed dilated, thin-walled bladders that had inflammatory infiltrates and foci of fibrosis replacing areas of damaged muscular layer. These lesions result from direct damage to the muscle fibers by the T. cruzi, leading to myosites, muscle damage, and scarring. Direct damage of paraganglia cells secondary to parasitism, leading to dilatation, damage of muscle fibers, and scarring with replacement of muscular tissue with connective tissue, should also be considered as a cause of functional disturbance of the urinary bladder.Os "mega-órgãos" na Doença de Chagas são bem conhecidos, especialmente os desenvolvidos no sistema digestivo. A infecção aguda apresenta parasitismo de diversas células, tecidos e órgãos, dentre eles a bexiga urinária. Camundongos Balb/c infectados com 100.000 formas sanguíneas de cepa Y de T. cruzi mostraram intenso parasitismo de todas camadas da bexiga urinária na fase aguda. Os parasitas foram encontrados na mucosa, submucosa, lâmina própria, muscular, adventícia e tecido adiposo, além das células descamadas para a luz do órgão. Para produzir a fase crônica, os animais foram inoculados com a mesma cepa, porém apenas inóculo com 50 formas sangüíneas. Após sessenta dias de infecção, detectamos dilatações da parede vesical, assim

  13. Blood Pressure Test

    Science.gov (United States)

    ... several blood pressure readings at home. Tracking your blood pressure readings It can be helpful in diagnosing or ... medication options might work best for you. Low blood pressure Low blood pressure that either doesn't cause ...

  14. Low Blood Pressure (Hypotension)

    Science.gov (United States)

    ... lowest at night and rises sharply on waking. Blood pressure: How low can you go? What's considered low ... low blood pressure. Medications that can cause low blood pressure Some medications can cause low blood pressure, including: ...

  15. Micturitional dryness and attitude of parents towards enuresis in ...

    African Journals Online (AJOL)

    Achievement of dryness was significantly related to low maternal education (p = 0.022) and low social class (p= 0.009). Twenty-four (26.7 %) children had nocturnal enuresis. Four (4.4 %) of these children also had diurnal enuresis. All the parents/guardians were aware about enuresis but only 9.8 % correctly identified it as ...

  16. Sodium valproate induced increased frequency of micturition and enuresis

    Science.gov (United States)

    Gosavi, Devesh D.; Suman, Akanksha; Jain, Manish

    2013-01-01

    Sodium valproate is a commonly used antiepileptic drug (AED) for control of a broad range of seizures. Adverse drug reactions (ADR) due to sodium valproate range from sedation to nausea, vomiting, weight gain, idiosyncratic adverse effects like hepatotoxicity and life threatening conditions like pancreatitis. We present a case of sodium valproate induced enuresis in child. This ADR of valproate is an underreported ADR and requires special attention of pediatricians as it can interfere with the further treatment of the disease. PMID:23543036

  17. Mobilidade do Colo Vesical e Avaliação Funcional do Assoalho Pélvico em Mulheres Continentes e com Incontinência Urinária de Esforço, Consoante o Estado Hormonal Bladder Neck Mobility and Functional Pelvic Floor Evaluation in Women with and without Stress Urinary Incontinence, According to Hormonal Status

    Directory of Open Access Journals (Sweden)

    Sonia Fátima da Silva Moreira

    2002-07-01

    Full Text Available Objetivo: estudar a mobilidade do colo vesical e a força da musculatura perineal em mulheres com e sem incontinência urinária de esforço, no menacme e na pós-menopausa. Métodos: foram avaliadas 61 pacientes, das quais 31 estavam no menacme, sendo 17 com incontinência urinária de esforço (IUE e 14 continentes, e 30 estavam na pós-menopausa, das quais 15 com e 15 sem IUE. Todas as incontinentes foram submetidas ao teste da coluna d'água e ao teste de esforço com bexiga vazia. A mobilidade do colo vesical foi avaliada pelo teste do cotonete e por ultra-sonografia e, para estudo da função da musculatura perineal, foram utilizados a palpação digital e cones vaginais. Resultados: a posição do colo vesical nas mulheres com incontinência urinária de esforço (grupos A e C, tanto pela ultra-sonografia quanto pelo teste do cotonete, foi mais baixa, sendo --11,8 cm no grupo A e --12,5 cm no grupo C, do que as mulheres continentes, nas quais o colo encontrava-se, em média, a +4,4 cm no grupo B e +2,3 cm no grupo D. Quanto à mobilidade do colo vesical, avaliada pela ultra-sonografia e pelo teste do cotonete, não houve diferença significativa entre os grupos continentes no menacme (9,1 cm e na pós-menopausa (9,5 cm. Também não houve diferença significativa entre os dois grupos incontinentes entre si (17,1 cm para o grupo A e 16,6 cm para o C. No entanto, a mobilidade foi significativamente maior nos grupos com incontinência urinária de esforço (A e C do que nos grupos continentes (B e D Verificamos que, quanto à avaliação da musculatura do assoalho pélvico, o teste realizado com cones vaginais e a avaliação funcional do assoalho pélvico mostraram índice 4 no grupo B e 3,4 no grupo D, indicando maior força muscular nas mulheres continentes, quando comparadas às incontinentes (2,9 e 2,3, respectivamente no menacme e na pós-menopausa. Conclusão: a mobilidade do colo vesical, avaliada por meio do teste do cotonete e da

  18. High Blood Pressure (Hypertension)

    Science.gov (United States)

    ... Print Page Text Size: A A A Listen High Blood Pressure (Hypertension) Nearly 1 in 3 American adults has high ... weight. How Will I Know if I Have High Blood Pressure? High blood pressure is a silent problem — you ...

  19. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Cord Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores Adult Injuries Spinal Cord Injury 101 ... with a spinal cord injury to do to prevent pressure sores? play_arrow Why is pressure relief ...

  20. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... know about pressure sores? play_arrow What do family members and caregivers need to do to prevent pressure sores? play_arrow What role does diet and hydration play in preventing pressure ...

  1. Hypertension (High Blood Pressure)

    Science.gov (United States)

    ... Situations Talking to Your Parents - or Other Adults Hypertension (High Blood Pressure) KidsHealth > For Teens > Hypertension (High Blood Pressure) Print ... rest temperature diet emotions posture medicines Why Is High Blood Pressure Bad? High blood pressure means a person's heart ...

  2. Sitting: pressure ulcer development.

    Science.gov (United States)

    Collins, F

    Seating is a major factor in pressure ulcer development, but it is frequently overlooked in the literature on pressure area management. Pressure ulcers are largely preventable and nurses are integral to the promotion of good practice. The author examines how implementing careful patient assessment, correct positioning and providing optimum seating equipment can help to reduce the risk of pressure ulcer development.

  3. Validity and Reliability of an Instrumented Speculum Designed to Minimize the Effect of Intra-abdominal Pressure on the Measurement of Pelvic Floor Muscle Strength

    Science.gov (United States)

    Ashton-Miller, James A.; Zielinski, Ruth; Miller, Janis M.; DeLancey, John O.L.

    2015-01-01

    Background Existing clinical measurements of pelvic floor muscle strength are contaminated by crosstalk from intra-abdominal pressure. We tested an improved instrumented speculum designed to minimize this crosstalk. The hypotheses were that the speculum yields: 1) maximum vaginal closure forces unrelated to intra-abdominal pressure, 2) discriminatory validity between women who have strong vs. weak pelvic floor muscles, and 3) acceptable test-retest reliability. Methods Maximum voluntary vaginal closure force was measured in 40 incontinent women (20–77 years) using the improved instrumented speculum on two visits spaced one month apart. At the baseline visit, intra-abdominal pressure was also estimated via intra-vesical catheterization during the vaginal closure force measurement. Subjective estimate of pelvic floor muscle strength was also assessed using digital palpation by a skilled examiner to determine group placement as “strong” (n=31) or “weak” (n=9). Findings Vaginal closure force was not significantly correlated with intra-abdominal pressure (r = −.26, p = .109). The groups with subjectively scored strong and weak pelvic floor muscles differed significantly by mean [SD] maximum vaginal closure force (3.8 [1.7] vs. 1.9 [0.8] N respectively, p < .01.) Across both time points the mean vaginal closure force was 3.42 [1.67] N with a range of .68 to 9.05 N. Mean Visit 1 and Visit 2 vaginal closure force scores did not differ (3.41 [1.8] and 3.42 [1.6] N, respectively). The vaginal closure force repeatability coefficient was 3.1 N. Interpretation The improved speculum measured maximum vaginal closure force without evidence of crosstalk from intra-abdominal pressure, while retaining acceptable discriminant validity and repeatability. PMID:25307868

  4. Validity and reliability of an instrumented speculum designed to minimize the effect of intra-abdominal pressure on the measurement of pelvic floor muscle strength.

    Science.gov (United States)

    Ashton-Miller, James A; Zielinski, Ruth; DeLancey, John O L; Miller, Janis M

    2014-12-01

    Measurements of pelvic floor muscle strength are contaminated by crosstalk from intra-abdominal pressure. We tested an improved instrumented speculum designed to minimize this crosstalk. The hypotheses were that the speculum yields: 1) maximum vaginal closure forces unrelated to intra-abdominal pressure, 2) discriminatory validity between women with strong vs. weak pelvic floor muscles, and 3) acceptable test-retest reliability. Maximum voluntary vaginal closure force was measured in 40 incontinent women (20-77 years) on two visits spaced one month apart. At the baseline visit, intra-abdominal pressure was also estimated via intra-vesical catheterization during the vaginal closure force measurement. Subjective estimate of pelvic floor muscle strength was also assessed using digital palpation by a skilled examiner to determine group placement as "strong" (n=31) or "weak" (n=9). Vaginal closure force was not significantly correlated with intra-abdominal pressure (r=-.26, P=.109). The groups with subjectively scored strong and weak pelvic floor muscles differed significantly by mean [SD] maximum vaginal closure force (3.8 [1.7] vs. 1.9 [0.8] N respectively, P<.01.) Across both time points the mean vaginal closure force was 3.42 [1.67] N with a range of .68 to 9.05 N. Mean Visit 1 and Visit 2 vaginal closure force scores did not differ (3.41 [1.8] and 3.42 [1.6] N, respectively). The vaginal closure force repeatability coefficient was 3.1N. The improved speculum measured maximum vaginal closure force without evidence of crosstalk from intra-abdominal pressure, while retaining acceptable discriminant validity and repeatability. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Pressure Dome for High-Pressure Electrolyzer

    Science.gov (United States)

    Norman, Timothy; Schmitt, Edwin

    2012-01-01

    A high-strength, low-weight pressure vessel dome was designed specifically to house a high-pressure [2,000 psi (approx. = 13.8 MPa)] electrolyzer. In operation, the dome is filled with an inert gas pressurized to roughly 100 psi (approx. = 690 kPa) above the high, balanced pressure product oxygen and hydrogen gas streams. The inert gas acts to reduce the clamping load on electrolyzer stack tie bolts since the dome pressure acting axially inward helps offset the outward axial forces from the stack gas pressure. Likewise, radial and circumferential stresses on electrolyzer frames are minimized. Because the dome is operated at a higher pressure than the electrolyzer product gas, any external electrolyzer leak prevents oxygen or hydrogen from leaking into the dome. Instead the affected stack gas stream pressure rises detectably, thereby enabling a system shutdown. All electrical and fluid connections to the stack are made inside the pressure dome and require special plumbing and electrical dome interfaces for this to be accomplished. Further benefits of the dome are that it can act as a containment shield in the unlikely event of a catastrophic failure. Studies indicate that, for a given active area (and hence, cell ID), frame outside diameter must become ever larger to support stresses at higher operating pressures. This can lead to a large footprint and increased costs associated with thicker and/or larger diameter end-plates, tie-rods, and the frames themselves. One solution is to employ rings that fit snugly around the frame. This complicates stack assembly and is sometimes difficult to achieve in practice, as its success is strongly dependent on frame and ring tolerances, gas pressure, and operating temperature. A pressure dome permits an otherwise low-pressure stack to operate at higher pressures without growing the electrolyzer hardware. The pressure dome consists of two machined segments. An O-ring is placed in an O-ring groove in the flange of the bottom

  6. Tratamento endoscópico das perfurações vesicais e uretrais devidas à utilização do suporte suburetral sintético para correção de incontinência urinária de esforço Endoscopic treatment of vesical and urethral perforations after tension-free vaginal tape (TVT® procedure for female stress urinary incontinence

    Directory of Open Access Journals (Sweden)

    Fabio Baracat

    2005-10-01

    Full Text Available A incontinência urinária de esforço é um problema prevalente em mulheres. As opções para seu tratamento vêm aumentando nos últimos tempos, havendo um direcionamento para as técnicas minimamente invasivas, com auxílio de material sintético. Com a utilização desses procedimentos, surgiram complicações incomuns, como perfuração vesical e uretral. As complicações estudadas foram devido à utilização de material sintético no tratamento de incontinência urinária de esforço e o tratamento endoscópico empregado. MATERIAL E MÉTODO: Onze pacientes foram tratadas com complicações decorrentes do tension-free vaginal tape, seis com faixa de polipropileno dentro da bexiga e cinco com erosão para uretra. Foi realizada ressecção endoscópica em todas as pacientes. RESULTADOS: Uma paciente persistiu com a faixa de polipropileno e foi submetida à nova ressecção endoscópica e cistoscopia controle após três meses era normal. CONCLUSÃO: Realização de ressecção endoscópica de faixas sintéticas intravesicais e intra-uretrais deve ser considerada uma boa alternativa no tratamento dessas complicações.Stress urinary incontinence is a problem that is prevalent in women, and its treatment with minimally invasive techniques using synthetic materials has increased recently, although the procedure has also brought increased occurrence of specific complications such as vesical and urethral perforations. We describe 11 cases of endoscopic correction of vesical and urethral perforations due to the use of synthetic material for the treatment of stress urinary incontinence. MATERIALS AND METHOD: Eleven patients were treated for complications after undergoing the TVT® (tension-free vaginal tape procedure; 6 of them had the polypropylene tape inside the bladder, and 5 had erosion of the urethra. Endoscopic resection of the polypropylene tapes was performed on all patients. RESULTS: A 6-month follow-up with cystoscopic control showed

  7. The effect of different types of abdominal binders on intra-abdominal pressure

    Directory of Open Access Journals (Sweden)

    Hua-Yu Zhang

    2016-01-01

    Full Text Available Objectives: To investigate the effect of non-elastic/elastic abdominal binders on intra-vesical pressure (IVP, physiological functions, and clinical outcomes in laparotomy patients at the perioperative stage. Methods: This prospective study was conducted from May to October 2014 at the Trauma Surgery Department, Daping Hospital, Chongqing, China. Laparotomy patients were randomly divided into non-elastic abdominal binder group (28 patients, and elastic abdominal binder group (29 patients. Binders were applied for 14 days following the operation, or until discharge. Demographic information, Sequential Organ Failure Assessment (SOFA and Acute Physiology and Chronic Health Evaluation II (APACHE-II scores (prior to the operation, on the first day after operation, the day IVP measurement was stopped, and one day before discharge, and outcomes were recorded. The IVP was measured before the operation to postoperative day 7. Results: There were no significant differences in the demographic information, outcomes, SOFA or APACHE-II scores between the 2 groups. Initial out-of-bed mobilization occurred earlier in the elastic binder group (3.2 ± 2.0 versus 5.0 ± 3.7 days, p=0.028. A greater increase in IVP was observed in the non-elastic binder group than in the elastic binder group (2.9 ± 1.1 versus 1.1 ± 0.7 mm Hg, p=0.000. Conclusion: Elastic binders have relatively little effect on IVP and are more helpful at promoting postoperative recovery than non-elastic binders. Therefore, elastic binders are more suitable for clinical use.

  8. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... which blood flows through blood vessels (arteries) at higher than normal pressures. Measuring Blood Pressure Blood pressure ... blood pressure are defined as having blood pressures higher than 120/80 mmHg. The following table outlines ...

  9. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood, which leads to secondary high blood pressure. Risk Factors Anyone can develop high blood pressure; however, ... history of high blood pressure can increase your risk for developing high blood pressure. Age Blood pressure ...

  10. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Back To Health Topics / High Blood Pressure High Blood Pressure Also known as Hypertension Leer en español ... vessels (arteries) at higher than normal pressures. Measuring Blood Pressure Blood pressure is the force of blood ...

  11. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... To Health Topics / High Blood Pressure High Blood Pressure Also known as Hypertension See also Information for ... arteries) at higher than normal pressures. Measuring Blood Pressure Blood pressure is the force of blood pushing ...

  12. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Back To Health Topics / High Blood Pressure High Blood Pressure Also known as Hypertension See also Information ... vessels (arteries) at higher than normal pressures. Measuring Blood Pressure Blood pressure is the force of blood ...

  13. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Back To Health Topics / High Blood Pressure High Blood Pressure Also known as Hypertension See also Information for ... vessels (arteries) at higher than normal pressures. Measuring Blood Pressure Blood pressure is the force of blood pushing ...

  14. Preventing High Blood Pressure

    Science.gov (United States)

    ... Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN Preventing High Blood Pressure: Healthy Living Habits Recommend on Facebook Tweet Share ... meal and snack options can help you avoid high blood pressure and its complications. Be sure to eat plenty ...

  15. High blood pressure - children

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007696.htm High blood pressure - children To use the sharing features on this page, please enable JavaScript. High blood pressure (hypertension) is an increase in the force of ...

  16. Blood Pressure Medicines

    Science.gov (United States)

    High blood pressure, also called hypertension, usually has no symptoms. But it can cause serious problems such as stroke, ... and kidney failure. If you cannot control your high blood pressure through lifestyle changes such as losing weight and ...

  17. High blood pressure - infants

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007329.htm High blood pressure - infants To use the sharing features on this page, please enable JavaScript. High blood pressure (hypertension) is an increase in the force of ...

  18. High blood pressure medications

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007484.htm High blood pressure medicines To use the sharing features on this page, please enable JavaScript. Treating high blood pressure will help prevent problems such as heart disease, ...

  19. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... it be increased? play_arrow What do family members and caregivers need to know about pressure sores? play_arrow What do family members and caregivers need to do to prevent pressure ...

  20. Preventing Pressure Sores

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    Full Text Available ... especially prone to pressure sores? play_arrow What parts of the body are most likely to develop ... play_arrow How long is the typical healing time for a pressure sore? play_arrow Why do ...

  1. Preventing Pressure Sores

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    Full Text Available ... L Sarah Harrison, OT Anne Bryden, OT The Role of the Social Worker after Spinal Cord Injury ... do to prevent pressure sores? play_arrow What role does diet and hydration play in preventing pressure ...

  2. Pressure vessel design manual

    CERN Document Server

    Moss, Dennis R

    2013-01-01

    Pressure vessels are closed containers designed to hold gases or liquids at a pressure substantially different from the ambient pressure. They have a variety of applications in industry, including in oil refineries, nuclear reactors, vehicle airbrake reservoirs, and more. The pressure differential with such vessels is dangerous, and due to the risk of accident and fatality around their use, the design, manufacture, operation and inspection of pressure vessels is regulated by engineering authorities and guided by legal codes and standards. Pressure Vessel Design Manual is a solutions-focused guide to the many problems and technical challenges involved in the design of pressure vessels to match stringent standards and codes. It brings together otherwise scattered information and explanations into one easy-to-use resource to minimize research and take readers from problem to solution in the most direct manner possible. * Covers almost all problems that a working pressure vessel designer can expect to face, with ...

  3. High Blood Pressure (Hypertension)

    Science.gov (United States)

    ... two types of high blood pressure. Primary (essential) hypertension For most adults, there's no identifiable cause of ... tends to develop gradually over many years. Secondary hypertension Some people have high blood pressure caused by ...

  4. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... to prevent pressure sores? play_arrow What role does diet and hydration play in preventing pressure sores ... for families facing spinal cord injuries. The website does not provide medical advice, recommend or endorse health ...

  5. Pressure surge attenuator

    Science.gov (United States)

    Christie, Alan M.; Snyder, Kurt I.

    1985-01-01

    A pressure surge attenuation system for pipes having a fluted region opposite crushable metal foam. As adapted for nuclear reactor vessels and heads, crushable metal foam is disposed to attenuate pressure surges.

  6. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores ... how are they treated? play_arrow When is surgical repair of a pressure sore required? play_arrow ...

  7. Preventing Pressure Sores

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    Full Text Available ... Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores Adult Injuries Spinal Cord Injury 101 David Chen, MD Preventing Pressure Sores Mary Zeigler, MS Transition from Hospital to ...

  8. Tunable high pressure lasers

    Science.gov (United States)

    Hess, R. V.

    1976-01-01

    Atmospheric transmission of high energy CO2 lasers is considerably improved by high pressure operation which, due to pressure broadening, permits tuning the laser lines off atmospheric absorption lines. Pronounced improvement is shown for horizontal transmission at altitudes above several kilometers and for vertical transmission through the entire atmosphere. Applications of tunable high pressure CO2 lasers to energy transmission and to remote sensing are discussed along with initial efforts in tuning high pressure CO2 lasers.

  9. High-pressure microbiology

    National Research Council Canada - National Science Library

    Michiels, Chris; Bartlett, Douglas Hoyt; Aertsen, Abram

    2008-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1. High Hydrostatic Pressure Effects in the Biosphere: from Molecules to Microbiology * Filip Meersman and Karel Heremans . . . . . . . . . . . . 2. Effects...

  10. Ambulatory blood pressure monitoring.

    OpenAIRE

    Nicholson, W R; Matthews, J. N.; O'Sullivan, J J; WREN, C.

    1993-01-01

    Ambulatory blood pressure monitoring (ABPM) in adults is proving to be useful. The aim of this study was to determine if ABPM is accurate in the lower blood pressure range encountered in children and, equally important, whether it is acceptable to children. Thirty one children, between the ages of 6 and 18 years, were assessed using an ambulatory blood pressure monitor that uses an auscultatory method. Blood pressure was measured in the contralateral arm with a mercury sphygmomanometer and an...

  11. High Blood Pressure Facts

    Science.gov (United States)

    ... Stroke Heart Disease Cholesterol Salt Million Hearts® WISEWOMAN High Blood Pressure Facts Recommend on Facebook Tweet Share Compartir On ... the facts about high blood pressure [PDF-255K] . High Blood Pressure in the United States About 75 million American ...

  12. High Blood Pressure (Hypertension)

    Science.gov (United States)

    ... other risk factors, like diabetes, you may need treatment. How does high blood pressure affect pregnant women? A few women will get high blood pressure when they are pregnant. When pregnant women get high blood pressure, it is called preeclampsia or toxemia. How do I control my high ...

  13. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... six stages of a pressure sore and how are they treated? play_arrow When is surgical repair of a pressure sore required? play_arrow How long is the typical healing time for a pressure sore? play_arrow Why do ...

  14. Pressure relieving support surfaces (PRESSURE) trial: cost effectiveness analysis

    National Research Council Canada - National Science Library

    Iglesias, Cynthia; Nixon, Jane; Cranny, Gillian; Nelson, E Andrea; Hawkins, Kim; Phillips, Angela; Torgerson, David; Mason, Su; Cullum, Nicky

    2006-01-01

    Abstract Objective To assess the cost effectiveness of alternating pressure mattresses compared with alternating pressure overlays for the prevention of pressure ulcers in patients admitted to hospital...

  15. Pressure locking test results

    Energy Technology Data Exchange (ETDEWEB)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  16. Pressure cryocooling protein crystals

    Science.gov (United States)

    Kim, Chae Un [Ithaca, NY; Gruner, Sol M [Ithaca, NY

    2011-10-04

    Preparation of cryocooled protein crystal is provided by use of helium pressurizing and cryocooling to obtain cryocooled protein crystal allowing collection of high resolution data and by heavier noble gas (krypton or xenon) binding followed by helium pressurizing and cryocooling to obtain cryocooled protein crystal for collection of high resolution data and SAD phasing simultaneously. The helium pressurizing is carried out on crystal coated to prevent dehydration or on crystal grown in aqueous solution in a capillary.

  17. Thermistor Pressure Gauge Design

    Science.gov (United States)

    Flanick, A. P.; Ainsworth, J. E.

    1961-01-01

    Thermistor pressure gauges are characterized by large pressure range, good accuracy and stability, fast measurement, insensitivity to over-pressure, negligible out-gassing, ease in cleaning, and physical and electrical simplicity and ruggedness. A number of excellent papers have been published describing these gauges. However, a detailed account of design procedure and characteristics for a specific gauge would eliminate much of the trial and error encountered in designing a gauge having prescribed range, sensitivity, and stability.

  18. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... complications. Preventing High Blood Pressure Onset Healthy lifestyle habits can help prevent high blood pressure from developing. It is important to check your blood pressure regularly. Children should have their blood pressure checked starting at ...

  19. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... those used to diagnose high blood pressure, prehypertension can progress to high blood pressure and should be ... pressure weakens and damages your blood vessels, which can lead to complications . Types of High Blood Pressure ...

  20. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... can help you track your blood pressure. Pregnancy Planning High blood pressure can cause problems for mother ... View all news on High Blood Pressure RELATED EVENT The Role of Microbiota in Blood Pressure Regulation ...

  1. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... pressures. Measuring Blood Pressure Blood pressure is the force of blood pushing against the walls of the ... blood pressure, sometimes called hypertension, happens when this force is too high. Health care workers check blood ...

  2. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood pressure and should be taken seriously. Over time, consistently high blood pressure weakens and damages your ... Blood Pressure When blood pressure stays high over time, it can damage the body and cause complications. ...

  3. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Card can help you track your blood pressure. Pregnancy Planning High blood pressure can cause problems for ... control your blood pressure before and during the pregnancy. Some women develop high blood pressure during pregnancy. ...

  4. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... the development of high blood pressure later in life. Environmental Causes of High Blood Pressure Environmental causes ... Tend to get high blood pressure earlier in life. Often, on average, have higher blood pressure numbers. ...

  5. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... sensor, and a blood pressure cuff. With this equipment, they measure: Systolic Pressure: blood pressure when the ... or at other locations that have blood pressure equipment and to keep a written log of all ...

  6. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... and large arteries, which can affect blood pressure. Genetic Causes of High Blood Pressure Much of the ... involved in high blood pressure has come from genetic studies. High blood pressure often runs in families. ...

  7. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... or its complications. Preventing High Blood Pressure Onset Healthy lifestyle habits can help prevent high blood pressure from developing. It is important to check your blood pressure regularly. Children should have their blood pressure checked starting at ...

  8. Pressurizing new reactors

    Energy Technology Data Exchange (ETDEWEB)

    Neill, J.S.

    1956-01-30

    The Technical Division was asked recently to consider designs for new reactors that would add 8000 MW capacity to the Savannah River Plant. One modification of the existing SRP design that would enable a higher power rating, and therefore require fewer new reactors, is an increase in the maximum pressure in the D{sub 2}O system. The existing reactors at SRP are designed for a maximum pressure in the gas plenum of only 5 psig. Higher pressures enable higher D{sub 2} temperatures and higher sheath temperatures without local boiling or burnout. The requirements in reactor cooling facilities at any given power level would therefore be reduced by pressurizing.

  9. DIGITAL BLOOD PRESSURE MONITOR

    Directory of Open Access Journals (Sweden)

    R. Fuentes

    2004-12-01

    Full Text Available In this work we present a blood pressure monitor which measures both the high blood pressure (systolic pressure,and the low blood pressure (diastolic pressure. It is a semiautomatic meter because the inflation of the occlusivecuff is carried out in a manual way. The transducer used is a piezoresistive silicon pressure sensor integrated onchip which provides a proportional voltage to the input pressure, with a measurement range from 0 to 50 kPa (0–7.3 PSI. The oscillometric method is employed, which consists on detecting the oscillometric signal on brachialartery, being processed at each pressure step, when the cuff is gradually deflated. Signal sampling is carried out ata rate determined by the heart rate.In order to program the digital electronics of the circuit we used Altera tools, with the compiler MAX-PLUS II, andthe device selected to implement the design was an EPM7128SLC84-15 CPLD (Complex Programmable LogicDevice

  10. Clamp Restrains Pressure Line

    Science.gov (United States)

    Aliberti, J. A.

    1982-01-01

    Safety restraint protects people and property if a high-pressure fitting fails. As long as pressure line remains attached at the fitting, clamp exerts essentially no force on hose. If fitting fails, force of fluid leaving free end of hose causes the cam on the clamp to compress hose with a positive locking action.

  11. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... can it be increased? play_arrow What do family members and caregivers need to know about pressure sores? play_arrow What do family members and caregivers need to do to prevent pressure sores? play_arrow ...

  12. A life under pressure

    DEFF Research Database (Denmark)

    Jacobsen, Jens Christian Brings; von Holstein-Rathlou, Niels-Henrik

    2012-01-01

    Microvessels live 'a life under pressure' in several ways. In a literal sense, vessels of the microcirculation are exposed to high levels of stress caused primarily by the intravascular pressure head. In a figurative sense, the individual vessel and the microvascular network as a whole must...

  13. Pulse pressure and diurnal blood pressure variation

    DEFF Research Database (Denmark)

    Knudsen, Søren Tang; Poulsen, Per Løgstrup; Hansen, Klavs Würgler

    2002-01-01

    BACKGROUND: In nondiabetic subjects pulse pressure (PP) is an independent predictor of cardiovascular disease and microalbuminuria. Reduced circadian blood pressure (BP) variation is a potential risk factor for the development of diabetic complications. We investigated the association between...... retinopathy, nephropathy, macrovascular disease, PP, and diurnal BP variation in a group of type 2 diabetic patients. METHODS: In 80 type 2 diabetic patients we performed 24-h ambulatory BP (AMBP) and fundus photographs. Urinary albumin excretion was evaluated by urinary albumin/creatinine ratio. Presence...... or absence of macrovascular disease was assessed by an independent physician. RESULTS: Forty-nine patients had no detectable retinal changes (grade 1), 13 had grade 2 retinopathy, and 18 had more advanced retinopathy (grades 3-6). Compared to patients without retinopathy (grade 1), patients with grades 2...

  14. Pressure Ulcers Surveillance Report

    Directory of Open Access Journals (Sweden)

    Zehra Esin Gencer

    2015-04-01

    Full Text Available Objective: Pressure ulcer is a chronic wound. It reduces the quality of life of the elderly and individuals with restricted range of motion. It prolongs hospital stay and increases the risk of complications. The cost is quite high. Preventive actions for the prevention of pressure ulcers should be developed. Planning protocols and standards of care are among the main targets. Material and Method: Research was conducted in one-year period between 2012 May and 2013 May on patients who were followed up in Akdeniz University Hospital clinics and intensive care unit with pressure ulcers. The research population consisted of 569 patients. Patient data were recorded in SPSS 16 for Windows program. Statistical analyzes were performed with retrospective methods. The demographic characteristics of patients with pressure ulcers were analyzed as frequency and descriptive statistics. Prevalence and incidence of one year were calculated. Results: Of the patients, 58% were males, 42% were females. Of the patients, 36% were in the age range of 61-80 years, and their average length of stay was 42,9 days. Of the patients, 70% were at stage 2 and 3. In 15% of patients pressure ulcers occurred on the first day of hospitalization. Pressure ulcers were developed between days 2 and 10 in 59% of the patients. Prevalence rate was 2.5%, the incidence was 1.9%, the prevalence rate was 5.9% in the intensive care unit. Conclusion: It is easier to prevent pressure ulcers than treating.

  15. Superconductivity under high pressure

    Energy Technology Data Exchange (ETDEWEB)

    Amaya, K.; Shimizu, K.; Takeda, K.; Tateiwa, N.; Muramatsu, T.; Ishizuka, M.; Kobayashi, T.C

    2003-05-01

    In part 1, we review techniques developed in our laboratory for producing the complex extreme condition of very low temperature and ultra-high pressure and those for measuring electrical resistance and magnetization of the sample confined in the extremely small space of the used pressure cell. In part 2, we review our experimental results in search for pressure-induced superconductivity, which have been obtained by the use of developed techniques. Typical examples are shown in the case of simple inorganic and organic molecular crystals, ionic crystals, and magnetic metals.

  16. High pressure induced superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Amaya, K.; Shimizu, K

    2003-10-15

    We have developed complex extreme condition of very low temperature down to 30 mK and ultra high pressure exceeding 200 GPa by assembling compact diamond anvil cell (DAC) on a powerful {sup 3}He/{sup 4}He dilution refrigerator. We have also developed measuring techniques of electrical resistance, magnetization and optical measurement for the sample confined in the sample space of the DAC. Using the newly developed apparatus and techniques, we have searched for superconductivity in various materials under pressure. In this paper, we will shortly review our newly developed experimental apparatus and techniques and discuss a few examples of pressure induced superconductivity which were observed recently.

  17. Pressure Safety Orientation Live #769

    Energy Technology Data Exchange (ETDEWEB)

    Glass, George [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-17

    Pressure Safety Orientation (course #769) introduces workers at Los Alamos National Laboratory (LANL) to the Laboratory Pressure Safety Program and to pressure-related hazards. This course also affords a hands-on exercise involving the assembly of a simple pressure system. This course is required for all LANL personnel who work on or near pressure systems and are exposed to pressure-related hazards. These personnel include pressure-system engineers, designers, fabricators, installers, operators, inspectors, maintainers, and others who work with pressurized fluids and may be exposed to pressure-related hazards.

  18. Preventing Pressure Sores

    Science.gov (United States)

    ... Preventing Pressure Sores Mary Zeigler, MS Transition from Hospital to Home Kim Eberhardt Muir, MS Coping with ... Disabilities Photography by Rona Talcott Website by Mobile Marketing LLC Understanding Spinal Cord Injury About Us Expert ...

  19. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Preventing Pressure Sores Mary Zeigler, MS Transition from Hospital to Home Kim Eberhardt Muir, MS Coping with ... Disabilities Photography by Rona Talcott Website by Mobile Marketing LLC Understanding Spinal Cord Injury About Us Expert ...

  20. Increased intracranial pressure

    Science.gov (United States)

    ... by pressing on important structures and by restricting blood flow into the brain. Many conditions can increase intracranial pressure. Common causes include: Aneurysm rupture and subarachnoid hemorrhage Brain tumor Encephalitis Head ...

  1. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Living with SCI Personal Experiences by Topic Resources Peer Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores Adult Injuries Spinal Cord Injury 101 David ...

  2. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores ... sores? What is a Spinal Cord Injury? SCI Medical Experts People Living With SCI Personal Experiences By ...

  3. Pressure Transducer Locations

    Data.gov (United States)

    National Aeronautics and Space Administration — Files are located here, defining the locations of the pressure transducers on the HIRENASD model. These locations also correspond to the locations that analysts...

  4. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Injury Chart Spinal Cord Injury Facts and Figures Care and Treatment After SCI Spinal Cord Injury ... Pressure Sores Mary Zeigler, MS Transition from Hospital to Home Kim Eberhardt Muir, MS Coping with a New ...

  5. Gasoline Reid Vapor Pressure

    Science.gov (United States)

    EPA regulates the vapor pressure of gasoline sold at retail stations during the summer ozone season to reduce evaporative emissions from gasoline that contribute to ground-level ozone and diminish the effects of ozone-related health problems.

  6. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Adult Injuries Spinal Cord Injury 101 David Chen, MD Preventing Pressure Sores Mary Zeigler, MS Transition from ... Rosenberg, PsyD Understanding SCI Rehabilitation Donald Peck Leslie, MD Adjusting to Social Life in a Wheelchair Lisa ...

  7. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Peer Counseling Blog About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores Adult Injuries Spinal Cord Injury 101 David Chen, MD Preventing ...

  8. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... About Media Donate Spinal Cord Injury Medical Expert Videos Topics menu Topics Preventing Pressure Sores Adult Injuries ... LLC Understanding Spinal Cord Injury About Us Expert Videos Contact Us Personal Experience Videos Blog Videos By ...

  9. Understanding Blood Pressure Readings

    Science.gov (United States)

    ... Facts About HBP • Know Your Numbers Introduction Hypertensive Crisis Monitoring Your Blood Pressure At ... to lower your HBP and prevent a heart attack. Lower your HBP now . Watch, Learn and ...

  10. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... Pressure Sores Mary Zeigler, MS Transition from Hospital to Home Kim Eberhardt Muir, MS Coping with a ... Understanding SCI Rehabilitation Donald Peck Leslie, MD Adjusting to Social Life in a Wheelchair Lisa Rosen, MS ...

  11. High Blood Pressure Fact Sheet

    Science.gov (United States)

    ... High Blood Pressure Salt Cholesterol Million Hearts® WISEWOMAN High Blood Pressure Fact Sheet Language: English (US) Español (Spanish) Recommend ... time. High blood pressure is also called hypertension. High Blood Pressure in the United States Having high blood pressure ...

  12. Home monitoring of blood pressure

    OpenAIRE

    McGrath, Barry P.

    2015-01-01

    Home blood pressure monitoring is the self-measurement of blood pressure by patients. In the diagnosis and management of high blood pressure it is complementary to 24-hour ambulatory blood pressure monitoring and clinic blood pressure measurements. Home monitoring can also help to identify white-coat and masked hypertension.

  13. Pressure multiplying dispenser

    Science.gov (United States)

    DeFord, Henry S.; Moss, Owen R.

    1986-01-01

    A pressure multiplying dispenser for delivering fluid, preferably as a spray to the atmosphere, from a source of fluid, preferably a spray bottle, is described. The dispenser includes in combination a hollow cylindrical member, a nozzle delivery tube within the cylindrical member and a hollow actuator piston slideable within the cylindrical member which acts to multiply the pressure of a squeeze applied to the spray bottle.

  14. Fluctuating shells under pressure

    Science.gov (United States)

    Paulose, Jayson; Vliegenthart, Gerard A.; Gompper, Gerhard; Nelson, David R.

    2012-01-01

    Thermal fluctuations strongly modify the large length-scale elastic behavior of cross-linked membranes, giving rise to scale-dependent elastic moduli. Whereas thermal effects in flat membranes are well understood, many natural and artificial microstructures are modeled as thin elastic shells. Shells are distinguished from flat membranes by their nonzero curvature, which provides a size-dependent coupling between the in-plane stretching modes and the out-of-plane undulations. In addition, a shell can support a pressure difference between its interior and its exterior. Little is known about the effect of thermal fluctuations on the elastic properties of shells. Here, we study the statistical mechanics of shape fluctuations in a pressurized spherical shell, using perturbation theory and Monte Carlo computer simulations, explicitly including the effects of curvature and an inward pressure. We predict novel properties of fluctuating thin shells under point indentations and pressure-induced deformations. The contribution due to thermal fluctuations increases with increasing ratio of shell radius to thickness and dominates the response when the product of this ratio and the thermal energy becomes large compared with the bending rigidity of the shell. Thermal effects are enhanced when a large uniform inward pressure acts on the shell and diverge as this pressure approaches the classical buckling transition of the shell. Our results are relevant for the elasticity and osmotic collapse of microcapsules. PMID:23150558

  15. High-pressure microfluidics

    Science.gov (United States)

    Hjort, K.

    2015-03-01

    When using appropriate materials and microfabrication techniques, with the small dimensions the mechanical stability of microstructured devices allows for processes at high pressures without loss in safety. The largest area of applications has been demonstrated in green chemistry and bioprocesses, where extraction, synthesis and analyses often excel at high densities and high temperatures. This is accessible through high pressures. Capillary chemistry has been used since long but, just like in low-pressure applications, there are several potential advantages in using microfluidic platforms, e.g., planar isothermal set-ups, large local variations in geometries, dense form factors, small dead volumes and precisely positioned microstructures for control of reactions, catalysis, mixing and separation. Other potential applications are in, e.g., microhydraulics, exploration, gas driven vehicles, and high-pressure science. From a review of the state-of-art and frontiers of high pressure microfluidics, the focus will be on different solutions demonstrated for microfluidic handling at high pressures and challenges that remain.

  16. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... pressure and maintain normal blood pressure readings. Healthy Eating To help treat high blood pressure, health care ... more about the DASH eating plan. Heart-Healthy Eating Your health care provider also may recommend heart- ...

  17. Diagnosis of High Blood Pressure

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  18. Diagnosis of High Blood Pressure

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  19. Diagnosis of High Blood Pressure

    Medline Plus

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  20. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Nervous System Activity The sympathetic nervous system has important functions in blood pressure regulation, including heart rate, ... prevent high blood pressure from developing. It is important to check your blood pressure regularly. Children should ...

  1. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... page from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, health care providers ... are consistently 140/90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy ...

  2. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood pressure. Primary High Blood Pressure Primary, or essential, high blood pressure is the most common type ... has no known cause, it might be called essential hypertension, primary hypertension, or idiopathic (id-ee-o- ...

  3. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood pressure, he or she can order additional tests to determine if your blood pressure is due to other conditions or medicines or if you have primary high blood pressure. ...

  4. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... of your blood pressure, he or she can order additional tests to determine if your blood pressure ... health and can lower high blood pressure. Stress management techniques include: Being physically active Listening to music ...

  5. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, health care providers diagnose ... consistently 140/90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and ...

  6. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... increase your risk for developing high blood pressure. Age Blood pressure tends to rise with age. About 65 percent of Americans age 60 or older have high blood pressure. However, ...

  7. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... harder and leading to high blood pressure. Medicines Prescription medicines such as asthma or hormone therapies, including ... aldosterone system leading to high blood pressure. Other Medical Causes of High Blood Pressure Other medical causes ...

  8. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... your blood pressure returns to your normal baseline range. Blood pressure normally rises with age and body ... 160 or higher OR 100 or higher The ranges in the table are blood pressure guides for ...

  9. Pressure Effect on Entrance Flow

    DEFF Research Database (Denmark)

    Christensen, Jens Horslund; Couch, Mark

    1997-01-01

    The paper reports on experimentally determined pressure drops associated with orifice and capillary dies, where the exit pressure is elevated. The effect of hydrostatic pressure up to 70 MPa is reported for PS, LDPE and PP melts.......The paper reports on experimentally determined pressure drops associated with orifice and capillary dies, where the exit pressure is elevated. The effect of hydrostatic pressure up to 70 MPa is reported for PS, LDPE and PP melts....

  10. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... System Activity The sympathetic nervous system has important functions in blood pressure regulation, including heart rate, blood pressure, and breathing rate. Researchers are ...

  11. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... increased blood volumes and high blood pressure. Sympathetic Nervous System Activity The sympathetic nervous system has important functions in blood pressure regulation, including ...

  12. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... outlines and defines high blood pressure severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom number) Prehypertension 120– ...

  13. Validation of brachial artery pressure reconstruction from finger arterial pressure

    NARCIS (Netherlands)

    Guelen, Ilja; Westerhof, Berend E.; van der Sar, Gertrude L.; van Montfrans, Gert A.; Kiemeneij, Ferdinand; Wesseling, Karel H.; Bos, Willem Jan W.

    2008-01-01

    Objective Measurement of finger artery pressure with Finapres offers noninvasive continuous blood pressure, which, however, differs from brachial artery pressure. Generalized waveform filtering and level correction may convert the finger artery pressure waveform to a brachial waveform. An upper-arm

  14. High Blood Pressure (Hypertension) (For Parents)

    Science.gov (United States)

    ... Pregnancy Healthy Food Shopping Healthy Drinks for Kids High Blood Pressure (Hypertension) KidsHealth > For Parents > High Blood Pressure (Hypertension) ... How Is High Blood Pressure Treated? What Is High Blood Pressure? Blood pressure is the pressure of blood against ...

  15. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... High Blood Pressure Explore High Blood Pressure What Is... Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living ... Confirming High Blood Pressure A blood pressure test is easy and painless and can be done in ...

  16. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Home / < Back To Health Topics / High Blood Pressure High Blood Pressure Also known as Hypertension Leer en español See ... defines high blood pressure severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom ...

  17. Pressure Effect on Extensional Viscosity

    DEFF Research Database (Denmark)

    Christensen, Jens Horslund; Kjær, Erik Michael

    1999-01-01

    The primary object of these experiments was to investigate the influence of hydrostatic pressure on entrance flow. The effect of pressure on shear and extensional viscosity was evaluated using an axis symmetric capillary and a slit die where the hydrostatic pressure was raised with valves....... The experiments show a significant increase in extensional viscosity with increasing pressure....

  18. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Home / < Back To Health Topics / High Blood Pressure High Blood Pressure Also known as Hypertension See also Information for ... defines high blood pressure severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom ...

  19. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... care provider may need to change or add medicines to your treatment plan over time. NHLBI’s My Blood Pressure Wallet Card can help you track your blood pressure. Pregnancy Planning High blood pressure can cause problems for mother and baby. High blood pressure can ...

  20. Human gallbladder pressure and volume

    DEFF Research Database (Denmark)

    Borly, L; Højgaard, L; Grønvall, S

    1996-01-01

    Increased gallbladder (GB) pressure is probably a part of the pathogenesis of acute cholecystitis, and measurements of GB pressure might therefore be of interest. The aim of this study was to validate a microtip pressure transducer for intraluminal GB pressure measurements. In vitro precision and...

  1. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood pressure: primary and secondary high blood pressure. Primary High Blood Pressure Primary, or essential, high blood pressure is the most ... known cause, it might be called essential hypertension, primary hypertension, or idiopathic (id-ee-o-PATH-ick) ...

  2. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... may stiffen small and large arteries, which can affect blood pressure. Genetic Causes of High Blood Pressure Much of the understanding of the body systems involved in high blood pressure has come from genetic studies. High blood pressure often runs in families. Years ...

  3. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... are two main types of high blood pressure: primary and secondary high blood pressure. Primary High Blood Pressure Primary, ... plan based on whether you were diagnosed with primary or secondary high blood pressure and if there is a ...

  4. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless and can be done ... high blood pressure. Using the results of your blood pressure test, your health care provider will diagnose prehypertension or ...

  5. Pressure simulation program

    NARCIS (Netherlands)

    Knoll, B.; Phaff, J.C.; Gids, W.F. de

    1995-01-01

    A computer program has been developed to predict the wind pressure coefficients Cp on facades and roofs of block shaped buildings. The program is based on fits of measured data, including wind shielding by obstacles and terrain roughness. Main advantages of the program are: it needs no expertise of

  6. Preventing Pressure Sores

    Medline Plus

    Full Text Available ... arrow Is it true that a pressure sore can develop in a few hours? play_arrow What's ... play_arrow What is “skin tolerance” and how can it be increased? play_arrow What do family ...

  7. GOLD PRESSURE VESSEL SEAL

    Science.gov (United States)

    Smith, A.E.

    1963-11-26

    An improved seal between the piston and die member of a piston-cylinder type pressure vessel is presented. A layer of gold, of sufficient thickness to provide an interference fit between the piston and die member, is plated on the contacting surface of at least one of the members. (AEC)

  8. Raised intracranial pressure

    African Journals Online (AJOL)

    of the cranium to compensate for the added volume. Once this compensatory reserve is exhausted, pressure increases and brain shifts may occur and result in herniation (Fig. 2). e compliance curve is expressed by plotting the ICP against an expanding volume. Once the compensatory reserve is exceeded the increase in ...

  9. PRESSURE-RESISTANT VESSEL

    NARCIS (Netherlands)

    Beukers, A.; De Jong, T.

    1997-01-01

    Abstract of WO 9717570 (A1) The invention is directed to a wheel-shaped pressure-resistant vessel for gaseous, liquid or liquefied material having a substantially rigid shape, said vessel comprising a substantially continuous shell of a fiber-reinforced resin having a central opening, an inner

  10. Intracranial Pressure Monitoring

    DEFF Research Database (Denmark)

    Raboel, P H; Bartek, J; Andresen, M

    2012-01-01

    Monitoring of intracranial pressure (ICP) has been used for decades in the fields of neurosurgery and neurology. There are multiple techniques: invasive as well as noninvasive. This paper aims to provide an overview of the advantages and disadvantages of the most common and well-known methods...

  11. Farmers under pressure

    DEFF Research Database (Denmark)

    Andrade, Stefan Bastholm; Anneberg, Inger

    2013-01-01

    of them face severe financial difficulties, divorce and psychiatric problems, which are connected to an increased risk of being convicted for the neglect of farm animals. The narratives bring forward themes of pressure related to financial trouble, technological break down, family problems, stress...

  12. Pressurized Vessel Slurry Pumping

    Energy Technology Data Exchange (ETDEWEB)

    Pound, C.R.

    2001-09-17

    This report summarizes testing of an alternate ''pressurized vessel slurry pumping'' apparatus. The principle is similar to rural domestic water systems and ''acid eggs'' used in chemical laboratories in that material is extruded by displacement with compressed air.

  13. High Pressure Biomass Gasification

    Energy Technology Data Exchange (ETDEWEB)

    Agrawal, Pradeep K [Georgia Tech Research Corporation, Atlanta, GA (United States)

    2016-07-29

    According to the Billion Ton Report, the U.S. has a large supply of biomass available that can supplement fossil fuels for producing chemicals and transportation fuels. Agricultural waste, forest residue, and energy crops offer potential benefits: renewable feedstock, zero to low CO2 emissions depending on the specific source, and domestic supply availability. Biomass can be converted into chemicals and fuels using one of several approaches: (i) biological platform converts corn into ethanol by using depolymerization of cellulose to form sugars followed by fermentation, (ii) low-temperature pyrolysis to obtain bio-oils which must be treated to reduce oxygen content via HDO hydrodeoxygenation), and (iii) high temperature pyrolysis to produce syngas (CO + H2). This last approach consists of producing syngas using the thermal platform which can be used to produce a variety of chemicals and fuels. The goal of this project was to develop an improved understanding of the gasification of biomass at high pressure conditions and how various gasification parameters might affect the gasification behavior. Since most downstream applications of synags conversion (e.g., alcohol synthesis, Fischer-Tropsch synthesis etc) involve utilizing high pressure catalytic processes, there is an interest in carrying out the biomass gasification at high pressure which can potentially reduce the gasifier size and subsequent downstream cleaning processes. It is traditionally accepted that high pressure should increase the gasification rates (kinetic effect). There is also precedence from coal gasification literature from the 1970s that high pressure gasification would be a beneficial route to consider. Traditional approach of using thermogravimetric analyzer (TGA) or high-pressure themogravimetric analyzer (PTGA) worked well in understanding the gasification kinetics of coal gasification which was useful in designing high pressure coal gasification processes. However

  14. Idiopathic Normal Pressure Hydrocephalus

    Directory of Open Access Journals (Sweden)

    Basant R. Nassar BS

    2016-04-01

    Full Text Available Idiopathic normal pressure hydrocephalus (iNPH is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed search engine of keywords “normal pressure hydrocephalus,” “diagnosis,” “shunt treatment,” “biomarkers,” “gait disturbances,” “cognitive function,” “neuropsychology,” “imaging,” and “pathogenesis,” articles were obtained for this review. The majority of the articles were retrieved from the past 10 years. The purpose of this review article is to aid general practitioners in further understanding current findings on the pathogenesis, diagnosis, and treatment of iNPH.

  15. Low-pressure

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Richard [Membrane Technology And Research, Inc., Newark, CA (United States); Kniep, Jay [Membrane Technology And Research, Inc., Newark, CA (United States); Hao, Pingjiao [Membrane Technology And Research, Inc., Newark, CA (United States); Chan, Chi Cheng [Membrane Technology And Research, Inc., Newark, CA (United States); Nguyen, Vincent [Membrane Technology And Research, Inc., Newark, CA (United States); Huang, Ivy [Membrane Technology And Research, Inc., Newark, CA (United States); Amo, Karl [Membrane Technology And Research, Inc., Newark, CA (United States); Freeman, Brice [Membrane Technology And Research, Inc., Newark, CA (United States); Fulton, Don [Membrane Technology And Research, Inc., Newark, CA (United States); Ly, Jennifer [Membrane Technology And Research, Inc., Newark, CA (United States); Lipscomb, Glenn [Membrane Technology And Research, Inc., Newark, CA (United States); Lou, Yuecun [Membrane Technology And Research, Inc., Newark, CA (United States); Gogar, Ravikumar [Membrane Technology And Research, Inc., Newark, CA (United States)

    2015-01-29

    This final technical progress report describes work conducted by Membrane Technology and Research, Inc. (MTR) for the Department of Energy (DOE NETL) on development of low-pressure membrane contactors for carbon dioxide (CO2) capture from power plant flue gas (award number DE-FE0007553). The work was conducted from October 1, 2011 through September 30, 2014. The overall goal of this three-year project was to build and operate a prototype 500 m2 low-pressure sweep membrane module specifically designed to separate CO2 from coal-fired power plant flue gas. MTR was assisted in this project by a research group at the University of Toledo, which contributed to the computational fluid dynamics (CFD) analysis of module design and process simulation. This report details the work conducted to develop a new type of membrane contactor specifically designed for the high-gas-flow, low-pressure, countercurrent sweep operation required for affordable membrane-based CO2 capture at coal power plants. Work for this project included module development and testing, design and assembly of a large membrane module test unit at MTR, CFD comparative analysis of cross-flow, countercurrent, and novel partial-countercurrent sweep membrane module designs, CFD analysis of membrane spacers, design and fabrication of a 500 m2 membrane module skid for field tests, a detailed performance and cost analysis of the MTR CO2 capture process with low-pressure sweep modules, and a process design analysis of a membrane-hybrid separation process for CO2 removal from coal-fired flue gas. Key results for each major task are discussed in the report.

  16. Aspirated High Pressure Compressor

    Science.gov (United States)

    2006-08-01

    suggested by the General Electric Company based on an advanced military engine concept intended for high speed flight. The resultant high flight...section, consisting of the two rotors, each on an computed points. The peak pressure ratio is 3.08 and the peak independent, electric motor-driven...instrumentation along Moto . .. ,oto2 with the test error analysis were given by Onnee [14). SFlywheel 2 BLOWDOWN OPERATION T--’..Exit-t-rottle

  17. DEFLECTION PRESSURE TESTER

    Science.gov (United States)

    Cooper, C.M.

    1961-01-01

    A method and apparatus for determining whether the jacket of a nuclear- fuel slug has a leak are described. The region of the jacket to be leak-tested is sealed off, and gas under pressure is applied thereto. If there is an imperfection, the gas will enter the jacket and bulge another region of the jacket. The bulge occurring is measured by a gage.

  18. Microbes under pressure

    Science.gov (United States)

    Hallatschek, Oskar

    In natural settings, microbes tend to grow in dense populations where they need to push against their surroundings to accommodate space for new cells. The associated contact forces play a critical role in a variety of population-level processes, including biofilm formation, the colonization of porous media, and the invasion of biological tissues.Here, we reveal a collective mechanism of confinement that promotes the build-up of large mechanical pressures in microbial populations. Microfluidic experiments on budding yeast populations in space-limited environments show that self-driven jamming arises from the gradual formation and sudden collapse of force chains driven by microbial proliferation, extending the framework of driven granular matter. The resulting contact pressures can become large enough to slow down cell growth, to delay the cell cycle in the G1 phase, and to strain or even destroy the microenvironment through crack propagation. Finally, we discuss how discuss how collective pushing dynamics can promote the emergence of mutational jackpot events. Our results suggest that self-driven jamming and build-up of large mechanical pressures is a natural tendency of microbes growing in confined spaces, contributing to microbial pathogenesis and biofouling. NIH NIGMS R01, Simons Foundation.

  19. Pressure Controlled Chemical Gardens.

    Science.gov (United States)

    Bentley, Megan R; Batista, Bruno C; Steinbock, Oliver

    2016-06-30

    The dissolution of metal salts in silicate solution can result in the growth of hollow precipitate tubes. These "chemical gardens" are a model of self-organization far from the equilibrium and create permanent macroscopic structures. The reproducibility of the growth process is greatly improved if the solid salt seed is replaced by a salt solution that is steadily injected by a pump; however, this modification of the original experiment eliminates the membrane-based osmotic pump at the base of conventional chemical gardens and does not allow for analyses in terms of the involved pressure. Here we describe a new experimental method that delivers the salt solution according to a controlled hydrostatic pressure. In one form of the experiment, this pressure slowly decreases as zinc sulfate solution flows into the silicate-containing reaction vessel, whereas a second version holds the respective solution heights constant. In addition to three known growth regimes (jetting, popping, budding), we observe single tubes that fill the vessel in a horizontally undulating but vertically layered fashion (crowding). The resulting, dried product has a cylindrical shape, very low density, and one continuous connection from top to bottom. We also present phase diagrams of these growth modes and show that the flow characteristics of our experiments follow a reaction-independent Hagen-Poiseuille equation.

  20. Correlação entre a pressão de perda à manobra de Valsalva e a pressão máxima de fechamento uretral com a história clínica em mulheres com incontinência urinária de esforço Correlation of Valsalva leak point pressure and maximal urethral closure pressure with clinical history in women with stress urinary incontinence

    Directory of Open Access Journals (Sweden)

    Paulo Cezar Feldner Jr

    2002-08-01

    Full Text Available Objetivo: analisar a relação entre a pressão de perda com manobra de Valsalva e a pressão máxima de fechamento uretral com a queixa clínica em mulheres com incontinência urinária de esforço. Métodos: estudo retrospectivo no qual foram incluídas 164 pacientes com diagnóstico de incontinência urinária de esforço ou mista atendidas no setor de Uroginecologia e Cirurgia Vaginal do Departamento de Ginecologia da UNIFESP/EPM. As pacientes submeteram-se à anamnese padronizada, exame físico e estudo urodinâmico. A pressão de perda foi mensurada sob manobra de Valsalva (Valsalva leak point pressure - VLPP, com volume vesical de 200 mL. O perfil uretral foi realizado utilizando-se cateter de fluxo número 8, sendo medida a pressão máxima de fechamento uretral (PMFU. As pacientes foram agrupadas conforme a queixa clínica de perda urinária aos esforços e realizou-se análise estatística por meio do teste de chi² para verificar a proporção entre as variáveis. Utilizou-se, a seguir, a análise de variância (ANOVA para verificar diferenças entre VLPP e PMFU com relação à gravidade subjetiva da incontinência. Resultados: a média de idade foi de 51,2 anos (19-82, sendo que 79 encontravam-se no menacme (48,2% e 85 (51,8% na pós-menopausa. A paridade média foi de 4,0 filhos (0-18. Houve correlação entre o número de pacientes com VLPP inferior a 60 cmH2O e a queixa clínica (pPurpose: to analyze the correlation between Valsalva leak point pressure and maximum urethral closure pressure and clinical symptoms in women with stress urinary incontinence. Methods: we analyzed retrospectively 164 patients with urodynamic diagnosis of stress and mixed urinary incontinence established by the Urogynecology and Vaginal Surgery Sector of UNIFESP/EPM. All patients were submmited to medical interview, physical examination and urodynamic study. Patients were divided into groups according to the subjective degree of stress urinary

  1. Nanoparticle Delivery Of RNAi Therapeutics For Ocular Vesicant Injury

    Science.gov (United States)

    2014-12-01

    temperature, this yielded the parameter combinations listed in Table S2. The pair potential was cut off at 2.5σ and shifted at the cutoff to eliminate...camptothecin prodrug block to prepare particles of different shape including spheres, smooth disks, flower -like large compound vesicles (LCVs), and...information on siRNA sustainability in live cells: asymmetric degradation of siRNA strands. Mol. Biosyst. 7:2110–13 120. Collingwood MA, Rose SD, Huang L

  2. Female Urethral Malignant Melanoma With Vesical Invasion: A Case Report

    Directory of Open Access Journals (Sweden)

    Alpaslan Akbas

    2010-02-01

    Full Text Available We report a 75-year-old female with a primary urethral malignant melanoma. A mass protruding from inside the urethra was detected on physical examination. Abdominopelvic magnetic resonance imaging revealed a mass extending from the urethra with dimensions of 4 × 2 cm, and periurethral heterogenous fatty planes consistent with infiltration. The histopathologic examination was consistent with HMB45(+ malignant melanoma. We performed cystourethrectomy and bilateral inguinal and pelvic lymphadenectomy in one session. The pathology report revealed primary malignant melanoma of the urethra invading the inferior bladder wall. The patient received no adjuvant therapy because of cardiopulmonary morbidities and the presence of multiple pulmonary metastases. The patient eventually died 13 months after surgery.

  3. Case Report: Giant Vesical Calculus | Aliyu | Nigerian Journal of ...

    African Journals Online (AJOL)

    BACKGROUND: Giant bladder calculi are not common in modern urologic practice and many have been found to grow to enormous proportions with minimal symptoms. METHOD: We report a 1.6 kg stone removed from the urinary bladder of a 48 year old Nigerian man. The stone increase in size associated with ...

  4. Characterization and Modulation of Proteins Involved in SM Vesication

    Science.gov (United States)

    2005-05-01

    Schematic diagram of the Id2 promoter reporter constructs; nine fragments (Id2-2755 or deletion constructs Id2- del 980, Id2-1329, Id2-850, Id2-204...3063. 49. Heisler G M, Grant R H, Gao W, Slusser J R. Solar ultraviolet-B radiation in urban environments: the case of Baltimore, Maryland. Photochem

  5. Vesical Calculus 10 Years Post Missing Intrauterine Contraceptive ...

    African Journals Online (AJOL)

    2013-10-07

    www.jstcr.org on Monday, October 07, 2013, IP: 41.135.175.93] || Click here to download free Android application for this journal ... obvious advantages over open surgery where possible. In this patient, open surgery was performed because of.

  6. vesical gossypiboma mimicking calculus: a report of two

    African Journals Online (AJOL)

    should be considered in the differential diagnosis of patients with persistent bladder symptoms and intravesical calcification following open prostatectomy. Key Words: gossypiboma, urinary bladder, calculus. INTRODUCTION. Gossypiboma is an iatrogenic mass lesion resulting from retention of a surgical sponge. The word ...

  7. Characterization and Modulation of Proteins Involved in Sulfur Mustard Vesication

    Science.gov (United States)

    2000-06-01

    p53 may negatively regulate p53-mediated transcriptional activation of genes important in the cell cycle and apoptosis ( Malanga and Althaus, 1997...differentiation in vitro. J. Cell. Physiol. 163, 105-114. Malanga , M., and Althaus, F. (1997). Poly(ADP-ribose): a negative regulator of p53 functions. In The 12th...Aggarwal, B. (1996) J. Interferon ribosylation Reactions, Cancun, Mexico Cytokine Res. 16, 259-267 59. Malanga , M., and Althaus, F. (1997) in The

  8. Use of Epidermolysis Bullosa Biomarkers in Models of Vesicant Injury

    Science.gov (United States)

    2006-09-01

    and/or erythema ; 2 = focal areas of necrosis, but tissue still pliable; 3 = less than 50% of tissue is necrotic, tissue firm and dry, and 4 = more...Biophys Res Commun 2006; 343(3):692-699. (6) Christiano AM, Uitto J. Polymorphism of the human genome: markers for genetic linkage analyses in

  9. Vesical Calculus 10 Years Post Missing Intrauterine Contraceptive ...

    African Journals Online (AJOL)

    Intravesical migration of intrauterine contraceptive device (IUCD) is rare. Early diagnosis of this rare entity is difficult because of its non‑specific manifestations and very low index of suspicion. We present this case of bladder stone following intravesical migration of IUCD found to have been missing since insertion 10 years ...

  10. Giant vesical calculus | Laubscher | South African Medical Journal

    African Journals Online (AJOL)

    An exceptional case of bladder stone is presented. The case is unusual as regards the size of the stone and the fact that the patient did··not seek medical assistance much earlier, as this was readily available. Furthermore, recovery after removal of the stone was remarkably quick, as evidenced by the clinical picture as well ...

  11. Giant vesical calculus | Laubscher | South African Medical Journal

    African Journals Online (AJOL)

    South African Medical Journal. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 68, No 6 (1983) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Download this PDF file. The PDF file you selected should ...

  12. Chronic Serratiaodorifera Infra-vesical, Extra-peritoneal Pelvic ...

    African Journals Online (AJOL)

    Radiological evaluation revealed a cystic mass lesion of 80mm diameter which was thought to be an ovarian cyst. The mass could not be found at laparotomy. Repeat radiological evaluation revealed that the mass was extra-peritoneal with very thick walls. It was located para-vaginally, below and in front of the urinary ...

  13. Prevention and Treatment of Vesication and Poisoning Caused by Arsenicals.

    Science.gov (United States)

    1981-02-01

    the past for the treatment of heavy netal intoxication. For exanple, Jinercaprol (3AL) (1), polyaminocarboxylic acids (?), D-penicillanine (3), and 1...acetyl-DL-penicillanine are useful in the treatment of poisoning by other heavy metals, they are devoid of any protective action under these...investigators and West German investigators have recommended that it replace BAL for treatment of heavy metal poisoning. SECURITY CLASSIFICATION OF

  14. A Model of Medical Countermeasures for Vesicant Exposure

    Science.gov (United States)

    2015-10-01

    their final version in a graphical user interface. This implementation of the model will include feedback and adjustments made after review of the...erythema in hairless guinea pigs after cutaneous sulfur mustard vapor exposure by pretreatment with niacinamide, promethazine and indomethacin. J Appl

  15. Social Stress Induced Pressure Breathing and Consequent Blood Pressure Oscillation

    NARCIS (Netherlands)

    Fokkema, Dirk S.; Koolhaas, Jaap M.; Meulen, Jan van der; Schoemaker, Regien

    1986-01-01

    A large amplitude blood pressure oscillation occurs during social defeat in a territorial fight between male rats, and during the application of a psychosocial stimulus associated with this defeat. Synchronous recording of blood pressure, intrathoracic pressure and diaphragm activity shows that the

  16. Effects of blood pressure and blood pressure reactivity on ...

    African Journals Online (AJOL)

    The study investigated whether the relationship between sex and experimental pain report was explained by blood pressure at rest, or during pain task, or both in healthy, young adult females. Univariate analyses indicated significant positive correlation between baseline systolic blood pressure, systolic blood pressure ...

  17. Reconstruction of brachial pressure from finger arterial pressure during orthostasis

    DEFF Research Database (Denmark)

    Bogert, Lysander W J; Harms, Mark P M; Pott, Frank

    2004-01-01

    In patients with recurrent syncope, monitoring of intra-arterial pressure during orthostatic stress testing is recommended because of the potentially sudden and rapid development of hypotension. Replacing brachial arterial pressure (BAP) by the non-invasively obtained finger arterial pressure (Fin...

  18. Reconstruction of brachial artery pressure from noninvasive finger pressure measurements

    NARCIS (Netherlands)

    Bos, W. J.; van Goudoever, J.; van Montfrans, G. A.; van den Meiracker, A. H.; Wesseling, K. H.

    1996-01-01

    Pulse wave distortions, mainly caused by reflections, and pressure gradients, caused by flow in the resistive vascular tree, may cause differences between finger and brachial artery pressures. These differences may limit the use of finger pressure measurements. We investigated whether brachial

  19. Delay Pressure Detection Method to Eliminate Pump Pressure Interference on the Downhole Mud Pressure Signals

    Directory of Open Access Journals (Sweden)

    Yue Shen

    2013-01-01

    Full Text Available The feasibility of applying delay pressure detection method to eliminate mud pump pressure interference on the downhole mud pressure signals is studied. Two pressure sensors mounted on the mud pipe in some distance apart are provided to detect the downhole mud continuous pressure wave signals on the surface according to the delayed time produced by mud pressure wave transmitting between the two sensors. A mathematical model of delay pressure detection is built by analysis of transmission path between mud pump pressure interference and downhole mud pressure signals. Considering pressure signal transmission characteristics of the mud pipe, a mathematical model of ideal low-pass filter for limited frequency band signal is introduced to study the pole frequency impact on the signal reconstruction and the constraints of pressure sensor distance are obtained by pole frequencies analysis. Theoretical calculation and numerical simulation show that the method can effectively eliminate mud pump pressure interference and the downhole mud continuous pressure wave signals can be reconstructed successfully with a significant improvement in signal-to-noise ratio (SNR in the condition of satisfying the constraints of pressure sensor distance.

  20. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... above. Confirming High Blood Pressure A blood pressure test is easy and painless and can be done ... provider’s office or clinic. To prepare for the test: Don’t drink coffee or smoke cigarettes for ...

  1. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... of physical activity Drinking too much alcohol Stress Family History A family history of high blood pressure raises the risk ... for high blood pressure and may run in families. Genetic causes of this condition are why family ...

  2. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... control high blood pressure; lifestyle changes such as weight loss can be highly effective in treating high blood ... your risk for health problems. Greater amounts of weight loss can improve blood pressure readings, lower LDL cholesterol , ...

  3. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... too high. Health care workers check blood pressure readings the same way for children, teens, and adults. ... Complications Because diagnosis is based on blood pressure readings, this condition can go undetected for years, as ...

  4. Medications for High Blood Pressure

    Science.gov (United States)

    ... Consumers Home For Consumers Consumer Updates Medications for High Blood Pressure Share Tweet Linkedin Pin it More sharing options ... age and you cannot tell if you have high blood pressure by the way you feel, so have your ...

  5. High blood pressure and diet

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007483.htm High blood pressure and diet To use the sharing features on ... diet is a proven way to help control high blood pressure . These changes can also help you lose weight ...

  6. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom number) Prehypertension ... in the table are blood pressure guides for adults who do not have any short-term serious ...

  7. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... or hormone therapies, including birth control pills and estrogen, and over-the-counter medicines such as cold ... pressure. Medicines to lower blood pressure include: Diuretics (Water or Fluid Pills): Flush excess sodium from your ...

  8. Diagnosis of High Blood Pressure

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    Full Text Available ... check blood pressure readings the same way for children, teens, and adults. They use a gauge, stethoscope ... prehypertension and high blood pressure is increasing for children and teens, possibly due to the rise in ...

  9. Diagnosis of High Blood Pressure

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    Full Text Available ... blood pressure test is easy and painless and can be done in a health care provider’s office ... severity of your blood pressure, he or she can order additional tests to determine if your blood ...

  10. Diagnosis of High Blood Pressure

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    Full Text Available ... can cause high blood pressure. Renin-Angiotensin-Aldosterone System The renin-angiotensin-aldosterone system makes angiotensin and ... blood volumes and high blood pressure. Sympathetic Nervous System Activity The sympathetic nervous system has important functions ...

  11. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... and to follow your prescribed treatment plan, which will include healthy lifestyle habit recommendations and possibly medicines. ... your blood pressure test, your health care provider will diagnose prehypertension or high blood pressure if: Your ...

  12. Diagnosis of High Blood Pressure

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    Full Text Available ... renin-angiotensin-aldosterone pathways. However, these known genetic factors only account for 2 to 3 percent of ... which leads to secondary high blood pressure. Risk Factors Anyone can develop high blood pressure; however, age, ...

  13. Diagnosis of High Blood Pressure

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  17. Diagnosis of High Blood Pressure

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    Full Text Available ... blood pressure readings the same way for children, teens, and adults. They use a gauge, stethoscope or ... that are considered normal for babies, while older teens have numbers similar to adults. Abnormal Blood Pressure ...

  18. Diagnosis of High Blood Pressure

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  19. Diagnosis of High Blood Pressure

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    Full Text Available ... track blood pressure readings over a period of time, the health care provider may ask you to ... the office on different days and at different times to take your blood pressure. The health care ...

  20. Diagnosis of High Blood Pressure

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    Full Text Available ... term serious illnesses. People with diabetes or chronic kidney disease should keep their blood pressure below 130/80 ... pressure include other medical conditions such as chronic kidney disease , sleep apnea , thyroid problems, or certain tumors. This ...

  1. Diagnosis of High Blood Pressure

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    Full Text Available ... Institute on Drug Abuse) High Blood Pressure (MedlinePlus) High Blood Pressure and Kidney Disease (National Institute of Diabetes and Digestive and Kidney Diseases) RELATED NEWS December ...

  2. Diagnosis of High Blood Pressure

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    Full Text Available ... habits. The combination of the medicines and the healthy lifestyle habits helps control and lower your high blood pressure. Some people develop “resistant” or uncontrolled high blood pressure. This ...

  3. Diagnosis of High Blood Pressure

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    Full Text Available ... control high blood pressure. Possible future treatments under investigation include new combination medicines, vaccines, and interventions aimed ... researchers on June 10, 2016, to share current scientific k... View all events on High Blood Pressure ...

  4. Diagnosis of High Blood Pressure

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    Full Text Available ... risk for prehypertension and high blood pressure is increasing for children and teens, possibly due to the ... II is a hormone that narrows blood vessels, increasing blood pressure. ACE converts Angiotensin I to Angiotensin ...

  5. Diagnosis of High Blood Pressure

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    Full Text Available ... 139 OR 80–89 High blood pressure Stage 1 140–159 OR 90–99 High blood pressure ... To help make lifelong lifestyle changes, try making one healthy lifestyle change at a time and add ...

  6. Diagnosis of High Blood Pressure

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    Full Text Available ... potassium Lack of physical activity Drinking too much alcohol Stress Family History A family history of high blood pressure raises the risk of developing prehypertension or high blood pressure. Some ...

  7. Diagnosis of High Blood Pressure

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    Full Text Available ... and High Blood Pressure Researchers continue to study how various changes in normal body functions cause high ... to an increase in blood pressure. Aldosterone controls how the kidneys balance fluid and salt levels. Increased ...

  8. Diagnosis of High Blood Pressure

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    Full Text Available ... Signs and symptoms include memory loss, difficulty finding words, and losing focus during conversations. Eye Damage: When ... pressure. Medicines to lower blood pressure include: Diuretics (Water or Fluid Pills): Flush excess sodium from your ...

  9. Diagnosis of High Blood Pressure

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    Full Text Available ... may stiffen small and large arteries, which can affect blood pressure. Genetic Causes of High Blood Pressure ... which plaque builds up in leg arteries and affects blood flow in the legs. When people have ...

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  11. Diagnosis of High Blood Pressure

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    Full Text Available ... Also known as Hypertension See also Information for Health Professionals What Is High blood pressure is a common ... Before age 55, men are more likely than women to develop high blood pressure. After age 55, ...

  12. Diagnosis of High Blood Pressure

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    Full Text Available ... Operations and Administration Advisory Committees Budget and Legislative Information Jobs and Working at the NHLBI Contact and ... Blood Pressure Also known as Hypertension See also Information for Health Professionals What Is High blood pressure ...

  13. Diagnosis of High Blood Pressure

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    Full Text Available ... or tai chi Meditating Medicines Blood pressure medicines work in different ways to stop or slow some of the body’s functions that cause high blood pressure. Medicines to lower ...

  14. Diagnosis of High Blood Pressure

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    Full Text Available ... the body’s salt balance by retaining sodium and water and excreting potassium. Imbalances in this kidney function ... pressure. Medicines to lower blood pressure include: Diuretics (Water or Fluid Pills): Flush excess sodium from your ...

  15. Diagnosis of High Blood Pressure

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    Full Text Available ... narrow, which can lower your blood pressure. Calcium Channel Blockers: Keep calcium from entering the muscle cells ... talk with your health care provider and take steps to control your blood pressure by making healthy ...

  16. Diagnosis of High Blood Pressure

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  17. Diagnosis of High Blood Pressure

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    Full Text Available ... health and can lower high blood pressure. Stress management techniques include: Being physically active Listening to music ... With DASH My Blood Pressure Wallet Card Other Resources Cigarette and Tobacco Facts (National Institute on ... OIG USA.gov

  18. Diagnosis of High Blood Pressure

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    Full Text Available ... families. Genetic causes of this condition are why family history is a risk factor for ... blood pressure regularly. Children should have their blood pressure checked starting at ...

  19. Diagnosis of High Blood Pressure

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    Full Text Available ... structure and function. Biology and High Blood Pressure Researchers continue to study how various changes in normal ... including heart rate, blood pressure, and breathing rate. Researchers are investigating whether imbalances in this system cause ...

  20. Diagnosis of High Blood Pressure

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    Full Text Available ... health and can lower high blood pressure. Stress management techniques include: Being physically active Listening to music ... Blood Pressure and Kidney Disease (National Institute of Diabetes and Digestive and Kidney Diseases) RELATED NEWS December ...

  1. Diagnosis of High Blood Pressure

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    Full Text Available ... ask for your readings. Blood Pressure Severity and Type Your health care provider usually takes 2–3 ... any other location. Health care providers diagnose this type of high blood pressure by reviewing readings in ...

  2. Diagnosis of High Blood Pressure

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    Full Text Available ... hormones in your blood, which leads to secondary high blood pressure. Risk Factors Anyone can develop high blood pressure; however, age, race or ethnicity, being overweight, gender, ...

  3. High Blood Pressure in Pregnancy

    Science.gov (United States)

    ... of the baby. Controlling your blood pressure during pregnancy and getting regular prenatal care are important for ... your baby. Treatments for high blood pressure in pregnancy may include close monitoring of the baby, lifestyle ...

  4. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... lead to cognitive changes. Signs and symptoms include memory loss, difficulty finding words, and losing focus during ... above. Confirming High Blood Pressure A blood pressure test is easy and painless and can be done ...

  5. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... weakens and damages your blood vessels, which can lead to complications . Types of High Blood Pressure There ... Angiotensin narrows or constricts blood vessels, which can lead to an increase in blood pressure. Aldosterone controls ...

  6. Diagnosis of High Blood Pressure

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    Full Text Available ... to keep a written log of all your results. Whenever you have an appointment with the health ... appointments to diagnose high blood pressure. Using the results of your blood pressure test, your health care ...

  7. Diagnosis of High Blood Pressure

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    Full Text Available ... your blood vessels, which can lead to complications . Types of High Blood Pressure There are two main ... ask for your readings. Blood Pressure Severity and Type Your health care provider usually takes 2–3 ...

  8. Diagnosis of High Blood Pressure

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    Full Text Available ... Ethnicity High blood pressure is more common in African American adults than in Caucasian or Hispanic American adults. Compared with these ethnic groups, African Americans: Tend to get high blood pressure earlier in ...

  9. Diagnosis of High Blood Pressure

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    Full Text Available ... lifestyle habits, proper use of medicines, and regular medical care can prevent high blood pressure or its complications. ... blood pressure, it is important to obtain regular medical care and to follow your prescribed treatment plan, which ...

  10. Diagnosis of High Blood Pressure

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    Full Text Available ... being overweight or obese, and medicines. Unhealthy Lifestyle Habits Unhealthy lifestyle habits can cause high blood pressure, ... than men to develop high blood pressure. Lifestyle Habits Unhealthy lifestyle habits can raise your risk for ...

  11. Diagnosis of High Blood Pressure

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    Full Text Available ... talk with your health care provider and take steps to control your blood pressure by making healthy ... your health care team so you can take steps to control your blood pressure before and during ...

  12. Diagnosis of High Blood Pressure

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    Full Text Available ... normal for babies, while older teens have numbers similar to adults. Abnormal Blood Pressure Abnormal increases in ... Salt A low-sodium diet can help you manage your blood pressure. You should try to limit ...

  13. Diagnosis of High Blood Pressure

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    Full Text Available ... system activity , and blood vessel structure and function. Biology and High Blood Pressure Researchers continue to study ... blood pressure often runs in families. Years of research have identified many genes and other mutations associated ...

  14. Diagnosis of High Blood Pressure

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    Full Text Available ... short-term serious illnesses. People with diabetes or chronic kidney disease should keep their blood pressure below ... blood pressure include other medical conditions such as chronic kidney disease , sleep apnea , thyroid problems, or certain ...

  15. Diagnosis of High Blood Pressure

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    Full Text Available ... bring your log of blood pressure readings. Every time you visit the health care provider, he or she should tell you what your blood pressure numbers are; if he or she does not, you should ...

  16. Diagnosis of High Blood Pressure

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    Full Text Available ... Imbalances in this kidney function can expand blood volumes, which can cause high blood pressure. Renin-Angiotensin- ... change this kidney function, leading to increased blood volumes and high blood pressure. Sympathetic Nervous System Activity ...

  17. Diagnosis of High Blood Pressure

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    Full Text Available ... is too high. Health care workers check blood pressure readings the same way for children, teens, and adults. They use a gauge, stethoscope or electronic sensor, and a blood pressure ...

  18. Diagnosis of High Blood Pressure

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    Full Text Available ... for 2 to 3 percent of all cases. Emerging research suggests that certain DNA changes during fetal ... blood, which leads to secondary high blood pressure. Risk Factors Anyone can develop high blood pressure; however, ...

  19. Diagnosis of High Blood Pressure

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    Full Text Available ... and Obesity Smoking and Your Heart Stroke Send a link to NHLBI to someone by E-MAIL | ... 90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless and ...

  20. Diagnosis of High Blood Pressure

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    Full Text Available ... of all cases. Emerging research suggests that certain DNA changes during fetal development also may cause the development of high blood pressure later in life. Environmental Causes of High Blood Pressure Environmental causes of ...

  1. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood pressure. Angiotensin-Converting Enzyme (ACE) Inhibitors : Angiotensin-II is a hormone that narrows blood vessels, increasing blood pressure. ACE converts Angiotensin I to Angiotensin II. ACE inhibitors block this process, which stops the ...

  2. Blood pressure monitors for home

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007482.htm Blood pressure monitors for home To use the sharing features ... may ask you to keep track of your blood pressure at home. To do this, you will need ...

  3. INTRACRANIAL PRESSURE MONITORING

    Directory of Open Access Journals (Sweden)

    Retno Widiyanthi

    2013-07-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Intracranial pressure is total of pressure that is produced by brain, blood, and cerebrospinal fluid/CSF in the tight cranial space. As a respon to intracranial pressure increasing, compensation begin by movement of CSF from ventricle to cerebral subarachnoidal space, and increase the absorption of CSF. Increasing of ICP usually caused by increasing of brain volume (cerebral oedem, blood (intracranial bleeding, space occupying lesion, or CSF (hidrocephalus. Indication in ICP monitoring can be seen from : neurological criteria, abnormal CT-scan result when admission, normal CT-scan result, but had more two risk factors. According to the procedure that must be done, there are two methods in ICP monitoring: invasive ICP monitoring methodes and non-invasive measuring method. Increasing of ICP will decrease the compliance of brain, pulsation of artery more clearly, and the component of vein is lost. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  4. Saltstone Osmotic Pressure

    Energy Technology Data Exchange (ETDEWEB)

    Nichols, Ralph L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Dixon, Kenneth L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRN

    2013-09-23

    Recent research into the moisture retention properties of saltstone suggest that osmotic pressure may play a potentially significant role in contaminant transport (Dixon et al., 2009 and Dixon, 2011). The Savannah River Remediation Closure and Disposal Assessments Group requested the Savannah River National Laboratory (SRNL) to conduct a literature search on osmotic potential as it relates to contaminant transport and to develop a conceptual model of saltstone that incorporates osmotic potential. This report presents the findings of the literature review and presents a conceptual model for saltstone that incorporates osmotic potential. The task was requested through Task Technical Request HLW-SSF-TTR- 2013-0004.

  5. Pressure difference receiving ears

    DEFF Research Database (Denmark)

    Michelsen, Axel; Larsen, Ole Næsbye

    2007-01-01

    waves behave in the air spaces leading to the interior surfaces of eardrums. A linear mathematical model with well-defined inputs is used for exploring how the directionality varies with the binaural directional cues and the amplitude and phase gain of the sound pathway to the inner surface...... of such pressure difference receiving ears have been hampered by lack of suitable experimental methods. In this review, we review the methods for collecting reliable data on the binaural directional cues at the eardrums, on how the eardrum vibrations depend on the direction of sound incidence, and on how sound...

  6. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Blood Pressure Much of the understanding of the body systems involved in high blood pressure has come from ... happens because medicines can change the way your body controls fluid and salt ... system leading to high blood pressure. Other Medical Causes ...

  7. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... blood pressure and maintain normal blood pressure readings. Healthy Eating To help treat high blood pressure, health care providers recommend that you limit sodium and salt intake, increase potassium, and eat foods that are heart healthy. Limiting Sodium and Salt ...

  8. Micromachined pressure/flow-sensor

    NARCIS (Netherlands)

    Oosterbroek, R.E.; Lammerink, Theodorus S.J.; Berenschot, Johan W.; Krijnen, Gijsbertus J.M.; Elwenspoek, Michael Curt; van den Berg, Albert

    The micromechanical equivalent of a differential pressure flow-sensor, well known in macro mechanics, is discussed. Two separate pressure sensors are used for the device, enabling to measure both, pressure as well as volume flow-rate. An integrated sensor with capacitive read-out as well as a

  9. Pressure Safety: Advanced Live 11459

    Energy Technology Data Exchange (ETDEWEB)

    Glass, George [Los Alamos National Laboratory

    2016-03-02

    Many Los Alamos National Laboratory (LANL) operations use pressure equipment and systems. Failure to follow proper procedures when designing or operating pressure systems can result in injuries to personnel and damage to equipment and/or the environment. This manual presents an overview of the requirements and recommendations that address the safe design and operation of pressure systems at LANL.

  10. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Card can help you track your blood pressure. Pregnancy Planning High blood pressure can cause problems for mother and ... before and during the pregnancy. Some women develop high blood pressure during pregnancy. When this happens, your health care provider will ...

  11. The Myth of Peer Pressure.

    Science.gov (United States)

    Ungar, Michael T.

    2000-01-01

    The construct of peer pressure was examined as part of a qualitative study of the determinants of mental health for 41 high-risk adolescents. While the concept of peer pressure enables adults to explain youths' troubling behaviors, content analysis of the participants' accounts of their lives reveals peer pressure to be a myth. (Author/MKA)

  12. Gas Pressure-Drop Experiment

    Science.gov (United States)

    Luyben, William L.; Tuzla, Kemal

    2010-01-01

    Most chemical engineering undergraduate laboratories have fluid mechanics experiments in which pressure drops through pipes are measured over a range of Reynolds numbers. The standard fluid is liquid water, which is essentially incompressible. Since density is constant, pressure drop does not depend on the pressure in the pipe. In addition, flow…

  13. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Advisory Committees Jobs Contact Us FAQs Home » Health Information for the Public » Health Topics » High Blood Pressure » Diagnosis of High Blood Pressure Explore High Blood Pressure What Is... Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living With Clinical ...

  14. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... other conditions or medicines or if you have primary high blood pressure. Health care providers can use this information to develop your ... blood pressure persists or is first diagnosed as primary high blood pressure, your ... your health care provider may change or update your treatment plan ...

  15. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... for the test: Don’t drink coffee or smoke cigarettes for 30 minutes prior to the test. Go ... DASH My Blood Pressure Wallet Card Other Resources Cigarette and Tobacco Facts (National Institute on Drug Abuse) High Blood Pressure (MedlinePlus) High Blood Pressure ...

  16. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Diagnosis of High Blood Pressure For most patients, health care providers diagnose high blood pressure when blood pressure ... and painless and can be done in a health care provider’s office or clinic. To prepare for the ...

  17. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... page from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, health care providers diagnose high ... are consistently 140/90 mmHg or above. Confirming High Blood Pressure A blood pressure test is easy and painless ...

  18. Pressure transients in pipeline systems

    DEFF Research Database (Denmark)

    Voigt, Kristian

    1998-01-01

    This text is to give an overview of the necessary background to do investigation of pressure transients via simulations. It will describe briefly the Method of Characteristics which is the defacto standard for simulating pressure transients. Much of the text has been adopted from the book Pressure...

  19. ORANGE JUICE AND BLOOD PRESSURE

    Directory of Open Access Journals (Sweden)

    M. F. VALIM

    2009-01-01

    Full Text Available

    Blood pressure is the force of blood against artery walls. It is measured in millimeters of mercury (mm Hg and recorded as two numbers: systolic pressure (as the heart contracts over diastolic pressure (as the heart relaxes between beats. High blood pressure (hypertension is defined as chronically elevated high blood pressure, with systolic blood pressure (SBP of 140 mm Hg or greater, and diastolic blood pressure (DBP of 90 mm Hg or greater. High blood pressure (HBP, smoking, abnormal blood lipid levels, obesity and diabetes are risk factors for coronary heart disease, the leading cause of death in the US. Lifestyle modifications such as engaging in regular physical activity, quitting smoking and eating a healthy diet (limiting intake of saturated fat and sodium and increasing consumption of fiber, fruits and vegetables are advocated for the prevention, treatment, and control of HBP. As multiple factors influence blood pressure, the effects of each factor are typically modest, particularly in normotensive subjects, yet the combined effects can be substantial. Nutrition plays an important role in influencing blood pressure. Orange juice should be included as part of any low sodium diet and/or any blood pressure reducing eating plan, as it is sodium free, fat-free and can help meet recommended levels of potassium intake that may contribute to lower BP.

  20. Pressure vessel design manual

    Energy Technology Data Exchange (ETDEWEB)

    Moss, D.R.

    1987-01-01

    The first section of the book covers types of loadings, failures, and stress theories, and how they apply to pressure vessels. The book delineates the procedures for designing typical components as well as those for designing large openings in cylindrical shells, ring girders, davits, platforms, bins and elevated tanks. The techniques for designing conical transitions, cone-cylinder intersections, intermediate heads, flat heads, and spherically dished covers are also described. The book covers the design of vessel supports subject to wind and seismic loads and one section is devoted to the five major ways of analyzing loads on shells and heads. Each procedure is detailed enough to size all welds, bolts, and plate thicknesses and to determine actual stresses.

  1. Parent-Pressure

    DEFF Research Database (Denmark)

    Jensen, Helle Strandgaard

    2016-01-01

    In this article, I examine change and continuity in conceptions of parental agency in public debates about children’s media consumption in Scandinavia, 1945-1975. During this period, public debates about the various kinds of media products children consumed were dominated by different groups....... However, a strong continuity in the debates was the negative influence parents were seen as having on children’s media consumption due to their lack of insight and interest in the topic. Drawing upon recent works on children’s media, consumption and enculturation, I analyse why the negative description...... of parents as co-consumers prevailed despite radical changes in views on children’s media consumption. In particular, I examine the shared inter-Scandinavian socio-cultural contexts that structured the changing professional and political groups’ pressure on parents to perform according to their norms...

  2. Partial pressure gauges

    CERN Document Server

    Peter, G J

    2007-01-01

    The determination of partial pressures in vacuum systems is usually performed by mass spectrometers. The most common type is the QMS. Quadrupole mass spectrometers were developed decades ago and have been used by vacuum specialists as a diagnostic tool since then. In the first part of the paper the principles of these mass spectrometers are briefly reviewed together with the key features of the instruments. This is necessary to operate these instruments. In the second part the boundary conditions which arise from the application as residual gas analyser in UHV/XHV plants are described. These lead to special versions of mass spectrometers. Results obtained with these instruments and typical artefacts in mass spectra obtained in the UHV are discussed.

  3. Starch Gelatinization Induced by High Hydrostatic Pressure

    National Research Council Canada - National Science Library

    Kazutaka YAMAMOTO

    2013-01-01

    .... Starch gelatinization can also be induced by high hydrostatic pressure. Requirements for pressure gelatinization may also differ depending on botanical origin of starch, pressure, water, and temperature...

  4. Internal pressure and solubility parameter as a function of pressure

    DEFF Research Database (Denmark)

    Verdier, Sylvain Charles Roland; Andersen, Simon Ivar

    2005-01-01

    The main goal of this work was to measure the solubility parameter of a complex mixture, such as a crude oil, especially as a function of pressure. Thus, its definition is explained, as well as the main approximations generally used in literature. Then, the internal pressure is investigated, since...... it is presented as an alternative of the solubility parameter. In this work, the assumption that internal pressure is a measure of the physical solubility parameter was made, i.e. representing the dispersion and polar forces. As for the pressure influence, it was seen that internal pressure reaches a maximum...... contrary to solubility parameter. An indirect method was chosen to estimate internal pressure, using thermal expansivities (determined by microcalorimetry) and isothermal compressibilities (determined by density measurements). The uncertainty is within 2% for the expansivity and 0.1% for the density. Five...

  5. Thermodynamic equilibrium at heterogeneous pressure

    Science.gov (United States)

    Vrijmoed, Johannes C.; Podladchikov, Yuri Y.

    2014-05-01

    Recent advances in metamorphic petrology point out the importance of grain-scale pressure variations in high-temperature metamorphic rocks. Pressures derived from chemical zonation using unconventional geobarometry based on equal chemical potentials fit mechanically feasible pressure variations. Here a thermodynamic equilibrium method is presented that predicts chemical zoning as a result of pressure variations by Gibbs energy minimization. Equilibrium thermodynamic prediction of the chemical zoning in the case of pressure heterogeneity is done by constraint Gibbs minimization using linear programming techniques. Compositions of phases considered in the calculation are discretized into 'pseudo-compounds' spanning the entire compositional space. Gibbs energies of these discrete compounds are generated for a given range and resolution of pressures for example derived by barometry or from mechanical model predictions. Gibbs energy minimization is subsequently performed considering all compounds of different composition and pressure. In addition to constraining the system composition a certain proportion of the system is constraint at a specified pressure. Input pressure variations need to be discretized and each discrete pressure defines an additional constraint for the minimization. The proportion of the system at each different pressure is equally distributed over the number of input pressures. For example if two input pressures P1 and P2 are specified, two constraints are added: 50 percent of the system is constraint at P1 while the remaining 50 percent is constraint at P2. The method has been tested for a set of 10 input pressures obtained by Tajčmanová et al. (2014) using their unconventional geobarometry method in a plagioclase rim around kyanite. Each input pressure is added as constraint to the minimization (1/10 percent of the system for each discrete pressure). Constraining the system composition to the average composition of the plagioclase rim

  6. Iliac venous pressure estimates central venous pressure after laparotomy.

    Science.gov (United States)

    Boone, Brian A; Kirk, Katherine A; Tucker, Nikia; Gunn, Scott; Forsythe, Raquel

    2014-09-01

    Central venous pressure (CVP) is traditionally obtained through subclavian or internal jugular central catheters; however, many patients who could benefit from CVP monitoring have only femoral lines. The accuracy of illiac venous pressure (IVP) as a measure of CVP is unknown, particularly following laparotomy. This was a prospective, observational study. Patients who had both internal jugular or subclavian lines and femoral lines already in place were eligible for the study. Pressure measurements were taken from both lines in addition to measurement of bladder pressure, mean arterial pressure, and peak airway pressure. Data were evaluated using paired t-test, Bland-Altman analysis, and linear regression. Measurements were obtained from 40 patients, 26 of which had laparotomy. The mean difference between measurements was 2.2 mm Hg. There were no significant differences between patients who had laparotomy and nonsurgical patients (P = 0.93). Bland-Altman analysis revealed a bias of 1.63 ± 2.44 mm Hg. There was no correlation between IVP accuracy and bladder pressure, mean arterial pressure, or peak airway pressure. IVP is an adequate measure of CVP, even in surgical patients who have had recent laparotomy. Measurement of IVP to guide resuscitation is encouraged in patients who have only femoral venous catheter access. Copyright © 2014. Published by Elsevier Inc.

  7. Pressures Detector Calibration and Measurement

    CERN Document Server

    AUTHOR|(CDS)2156315

    2016-01-01

    This is report of my first and second projects (of 3) in NA61. I did data taking and analysis in order to do calibration of pressure detectors and verified it. I analyzed the data by ROOT software using the C ++ programming language. The first part of my project was determination of calibration factor of pressure sensors. Based on that result, I examined the relation between pressure drop, gas flow rate of in paper filter and its diameter.

  8. Why ambulatory blood pressure monitoring?

    Science.gov (United States)

    Punzi, H A

    1998-11-15

    Factors that affect the reliability and accuracy of blood pressure measurements are reviewed, and new technologies for measuring blood pressure are discussed. Blood pressure measurements obtained in an office, hospital, or clinic are subject to variation and error. Reasons for variations include the wrong cuff size, improper inflation or deflation technique, and patient apprehension ("white-coat syndrome"). Ambulatory blood pressure monitoring (ABPM) involves the use of a fully automated standard arm cuff that is inflated at predetermined intervals by a small battery-powered pump unit. The most reliable ABPM method is the oscillometric method, which detects subtle changes in air pressure within the cuff system caused by fluctuations of the brachial artery. The process for interpreting 24-hour ABPM data is still evolving. Twenty-four-hour ABPM has been shown to eliminate white-coat hypertension and is also useful for assessing patients whose blood pressure is inappropriately high in the absence of end organ damage, monitoring persons at risk of developing hypertension because of their race or family history, determining a medication's 24-hour effect on blood pressure, and assessing the early-morning rapid rise in blood pressure, which has been linked to an increased risk of nonembolic stroke and myocardial infarction. ABPM enables identification of patients whose blood pressure is elevated in the office but normal at home, allows more appropriate screening of patients for clinical trials, gives reproducible values, and enables evaluation of drug duration and action.

  9. The infinite line pressure probe

    Science.gov (United States)

    Englund, D. R.; Richards, W. B.

    1985-01-01

    The infinite line pressure probe provides a means for measuring high frequency fluctuating pressures in difficult environments. A properly designed infinite line probe does not resonate; thus its frequency response is not limited by acoustic resonance in the probe tubing, as in conventional probes. The characteristics of infinite line pressure probes are reviewed and some applications in turbine engine research are described. A probe with a flat-oval cross section, permitting a constant-impedance pressure transducer installation, is described. Techniques for predicting the frequency response of probes with both circular and flat-oval cross sections are also cited.

  10. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... of Intramural Research Research Resources Research Meeting Summaries Technology Transfer ... » Health Information for the Public » Health Topics » High Blood Pressure » ...

  11. Structure integrity assessment of pressurizer

    Energy Technology Data Exchange (ETDEWEB)

    Gubeljak, N.; Predan, J. (University of Maribor, Faculty of Mech. Eng., Maribor (Slovenia)); Vojvodie-Tuma, J. (Inst. for Metals and Technology, Ljubljana (Slovenia)); Kljajin, M. (University of Osijek, Faculty of Mech. Engineering , Brod (Croatia))

    2009-07-01

    Mechanical properties and fracture toughness testing of substrate pressurizer material is performed on simulated cast with same chemical composition and same production treatment as original material in Nuclear Power Plant. Tests were performed on artificially 2 years aged specimens at service temperature 300 deg C. The fracture toughness values in term of J-integral=81 N/mm was determined according to ASTM test procedure. Mechanical properties of clad and weld metal are taken from ASME Boiler and Pressure Vessel Code. Considering the material and physical properties of pressurizer bottom and internal pressure, the numerical analysis of displacement and stress distribution through the thickness was performed

  12. Advanced Pressure Boundary Materials

    Energy Technology Data Exchange (ETDEWEB)

    Santella, Michael L [ORNL; Shingledecker, John P [ORNL

    2007-01-01

    Increasing the operating temperatures of fossil power plants is fundamental to improving thermal efficiencies and reducing undesirable emissions such as CO{sub 2}. One group of alloys with the potential to satisfy the conditions required of higher operating temperatures is the advanced ferritic steels such as ASTM Grade 91, 9Cr-2W, and 12Cr-2W. These are Cr-Mo steels containing 9-12 wt% Cr that have martensitic microstructures. Research aimed at increasing the operating temperature limits of the 9-12 wt% Cr steels and optimizing them for specific power plant applications has been actively pursued since the 1970's. As with all of the high strength martensitic steels, specifying upper temperature limits for tempering the alloys and heat treating weldments is a critical issue. To support this aspect of development, thermodynamic analysis was used to estimate how this critical temperature, the A{sub 1} in steel terminology, varies with alloy composition. The results from the thermodynamic analysis were presented to the Strength of Weldments subgroup of the ASME Boiler & Pressure Vessel Code and are being considered in establishing maximum postweld heat treatment temperatures. Experiments are also being planned to verify predictions. This is part of a CRADA project being done with Alstom Power, Inc.

  13. Estimation of vapour pressure and partial pressure of subliming ...

    Indian Academy of Sciences (India)

    Administrator

    temperature curves are calculated at 80, 160 and 1000 mbar for salicylic acid and vanadyl bis-2,4- pentanedionate, a precursor used for chemical vapour deposition of vanadium oxides. Using a modification of the Langmuir equation, the partial pressure of these materials at different total pressures is also determined.

  14. PRESSURE ULCERS ASSESSMENT THROUGH THE PRESSURE ULCER SCALE FOR HEALING APPLICATION (PUSH

    Directory of Open Access Journals (Sweden)

    Stefy Letícia Pessoa Silveira

    2013-03-01

    Full Text Available OBJETIVO: avaliar úlceras por pressão(UPP com enfoque na aplicação da escala PUSH. METODOLOGIA: Realizou-se entre setembro-outubro de 2010, estudo longitudinal prospectivo em três Unidades de Terapia Intensiva de um Hospital, Teresina, Piauí com amostra de 19 pacientes e 134 aplicações da PUSH, não probabilística por conveniência. RESULTADOS: caracterizada pelo predomínio de UPP no sexo feminino(52,6%, ≥ 80 anos(36,8% e cor parda(52,6%;. Prevaleceu cuidadores diretos-filhos(73,7%. Todos os pacientes apresentaram sonda vesical, incontinência intestinal, restrição ao leito com média de 1,18 anos (±5,18, limitações em 73,68% causada pela doença de base e 84,2% inconscientes. A prevalência de UPP foi 61,29%, das quais 63,33% localizadas na região sacral, grau II, 29,6% tratadas com óleo AGE. Houve queda ou manutenção dos escores da escala. CONCLUSÃO: a PUSH é útil na avaliação da cicatrização de feridas permitindo monitorar resultados globais e apresentando-se válida para integrar protocolos, a fim de implementar a assistência de enfermagem.

  15. Pressurized Lunar Rover (PLR)

    Science.gov (United States)

    Creel, Kenneth; Frampton, Jeffrey; Honaker, David; McClure, Kerry; Zeinali, Mazyar; Bhardwaj, Manoj; Bulsara, Vatsal; Kokan, David; Shariff, Shaun; Svarverud, Eric

    The objective of this project was to design a manned pressurized lunar rover (PLR) for long-range transportation and for exploration of the lunar surface. The vehicle must be capable of operating on a 14-day mission, traveling within a radius of 500 km during a lunar day or within a 50-km radius during a lunar night. The vehicle must accommodate a nominal crew of four, support two 28-hour EVA's, and in case of emergency, support a crew of six when near the lunar base. A nominal speed of ten km/hr and capability of towing a trailer with a mass of two mt are required. Two preliminary designs have been developed by two independent student teams. The PLR 1 design proposes a seven meter long cylindrical main vehicle and a trailer which houses the power and heat rejection systems. The main vehicle carries the astronauts, life support systems, navigation and communication systems, lighting, robotic arms, tools, and equipment for exploratory experiments. The rover uses a simple mobility system with six wheels on the main vehicle and two on the trailer. The nonpressurized trailer contains a modular radioisotope thermoelectric generator (RTG) supplying 6.5 kW continuous power. A secondary energy storage for short-term peak power needs is provided by a bank of lithium-sulfur dioxide batteries. The life support system is partly a regenerative system with air and hygiene water being recycled. A layer of water inside the composite shell surrounds the command center allowing the center to be used as a safe haven during solar flares. The PLR 1 has a total mass of 6197 kg. It has a top speed of 18 km/hr and is capable of towing three metric tons, in addition to the RTG trailer. The PLR 2 configuration consists of two four-meter diameter, cylindrical hulls which are passively connected by a flexible passageway, resulting in the overall vehicle length of 11 m. The vehicle is driven by eight independently suspended wheels. The dual-cylinder concept allows articulated as well as double

  16. Solvation pressure as real pressure: I. Ethanol and starch under negative pressure

    CERN Document Server

    Uden, N W A V; Faux, D A; Tanczos, A C; Howlin, B; Dunstan, D J

    2003-01-01

    The reality of the solvation pressure generated by the cohesive energy density of liquids is demonstrated by three methods. Firstly, the Raman spectrum of ethanol as a function of cohesive energy density (solvation pressure) in ethanol-water and ethanol-chloroform mixtures is compared with the Raman spectrum of pure ethanol under external hydrostatic pressure and the solvation pressure and hydrostatic pressure are found to be equivalent for some transitions. Secondly, the bond lengths of ethanol are calculated by molecular dynamics modelling for liquid ethanol under pressure and for ethanol vapour. The difference in bond lengths between vapour and liquid are found to be equivalent to the solvation pressure for the C-H sub 3 , C-H sub 2 and O-H bond lengths, with discrepancies for the C-C and C-O bond lengths. Thirdly, the pressure-induced gelation of potato starch is measured in pure water and in mixtures of water and ethanol. The phase transition pressure varies in accordance with the change in solvation pre...

  17. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... health and can lower high blood pressure. Stress management techniques include: Being physically active Listening to music or focusing on something calm or peaceful Performing yoga or tai chi Meditating Medicines Blood pressure medicines work in different ways to stop or slow some of the ...

  18. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... of Intramural Research Research Resources Research Meeting Summaries Technology Transfer Clinical Trials What Are Clinical Trials? Children & ... or at other locations that have blood pressure equipment and to keep a written ... at several medical appointments to diagnose high blood pressure. Using the ...

  19. High Blood Pressure and Women

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More High Blood Pressure and Women Updated:Dec 14,2016 Pregnancy and ... Women . This content was last reviewed October 2016. High Blood Pressure • Home • Get the Facts About HBP • Know Your ...

  20. Common High Blood Pressure Myths

    Science.gov (United States)

    ... Artery Disease Venous Thromboembolism Aortic Aneurysm More Common High Blood Pressure Myths Updated:Dec 8,2017 Knowing the facts ... health. This content was last reviewed October 2016. High Blood Pressure • Home • Get the Facts About HBP Introduction What ...

  1. What Is High Blood Pressure?

    Science.gov (United States)

    ... Disease Venous Thromboembolism Aortic Aneurysm More What is High Blood Pressure? Updated:Oct 5,2017 First, let’s define high ... resources . This content was last reviewed October 2016. High Blood Pressure • Home • Get the Facts About HBP Introduction What ...

  2. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... your risk for health problems. Greater amounts of weight loss can improve blood pressure readings, lower LDL cholesterol , ... blood pressure and triglyceride levels, a type of fat found in the blood. Alcohol also adds extra calories, which may cause weight gain. Men should have no more than two ...

  3. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... other conditions or medicines or if you have primary high blood pressure. Health care providers can use this information to develop your treatment plan. Some people have “white coat hypertension.” This happens when blood pressure readings are only high when taken in a health ...

  4. High Pressure Research on Materials

    Indian Academy of Sciences (India)

    basic types of apparatus that are now being used throughout the world. He was awarded the Nobel Prize in Physics in 1946. The static high pressure generating devices can be divided into two categories: piston-cylinder and opposed anvil devices. These devices with their pressure capabilities are listed in Figure 4.

  5. Pressure drop in contraction flow

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz

    This note is a supplement to Dynamic of Polymeric Liquids (DPL) page 178. DPL gives an equation for the pressure drop in a tapered (and circular) contraction, valid only at low angles. Here the general definition of contraction flow (the Bagley correction) and a more general method to find...... the pressure drop in a contraction are given....

  6. High Pressure Research on Materials

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 12; Issue 6. High Pressure Research on Materials - Production and Measurement of High Pressures in the Laboratory. P Ch Sahu N V Chandra Shekar. General Article Volume 12 Issue 6 June 2007 pp 10-23 ...

  7. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... pressure readings, lower LDL cholesterol , and increase HDL cholesterol . However, research shows that no matter your weight, it is important to control high blood pressure to maintain good health. A useful measure of overweight and obesity is body mass index (BMI). BMI measures your ...

  8. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... learn how to check your blood pressure at home. Your health care provider can help you learn how to do ... to lower the chance of complications. With such care, most women and babies have good ... Resources Healthy Hearts, Healthy Homes: Keep the Beat: Control Your High Blood Pressure/ ...

  9. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... short-term serious illnesses. People with diabetes or chronic kidney disease should keep their blood pressure below 130/80 ... blood pressure include other medical conditions such as chronic kidney disease , sleep apnea , thyroid problems, or certain tumors. This ...

  10. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... cause high blood pressure. Blood Vessel Structure and Function Changes in the structure and function of small and large arteries may contribute to ... to stop or slow some of the body’s functions that cause high blood pressure. Medicines to lower ...

  11. Diabetes and blood pressure (image)

    Science.gov (United States)

    People with diabetes have a higher risk for heart attacks and strokes. Your doctor or nurse should check your blood pressure ... People with diabetes have a higher risk for heart attacks and strokes. Your doctor or nurse should check your blood pressure ...

  12. Pressure distribution on spinning spinnerets

    Directory of Open Access Journals (Sweden)

    Zhang Li

    2013-01-01

    Full Text Available A two-dimensional model is used to study the pressure distribution in a chamber of a spinneret system. Darcy’s law is adopted for determining the inlet and outlet velocities of the flow. The pressure distribution on the spinneret plate is obtained, and the dead zone, where no nozzle exists, can be optimally determined.

  13. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory Committees Budget ... health and can lower high blood pressure. Stress management techniques include: Being physically ... SPRINT trial played a key role in the evolution of the new blood pressure ...

  14. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... physical health and can lower high blood pressure. Stress management techniques include: Being physically active Listening to music or focusing on something calm or peaceful Performing yoga or tai chi Meditating Medicines Blood pressure medicines work in different ways to stop or slow some ...

  15. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... can help you control high blood pressure. These habits include: Healthy eating Being physically active Maintaining a healthy weight Limiting ... earlier changes. When you practice several healthy lifestyle habits, you are more likely to lower ... Eating To help treat high blood pressure, health care ...

  16. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... provider’s office compared with readings taken in any other location. Health care providers diagnose this type of high blood pressure ... high blood pressure and reduce your risk for other health problems. Talk with your health care provider before you start a new exercise plan. ...

  17. Electronically-Scanned Pressure Sensors

    Science.gov (United States)

    Coe, C. F.; Parra, G. T.; Kauffman, R. C.

    1984-01-01

    Sensors not pneumatically switched. Electronic pressure-transducer scanning system constructed in modular form. Pressure transducer modules and analog to digital converter module small enough to fit within cavities of average-sized wind-tunnel models. All switching done electronically. Temperature controlled environment maintained within sensor modules so accuracy maintained while ambient temperature varies.

  18. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory Committees Budget ... health and can lower high blood pressure. Stress management techniques include: Being physically ... pressure medicines work in different ways to stop or slow some of the ...

  19. Earth Pressure on Tunnel Crown

    DEFF Research Database (Denmark)

    Andersen, Lars

    Two different analyses have been carried out in order to find the vertical earth pressure, or overburden pressure, at the crown of a tunnel going through a dike. Firstly, a hand calculation is performed using a simple dispersion of the stresses over depth. Secondly, the finite‐element program...

  20. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Stroke Other Resources Many resources are available for support and to provide additional information on high blood pressure not found elsewhere in this Health Topic. NHLBI Resources Healthy Hearts, Healthy Homes: Keep the Beat: Control Your High Blood Pressure/ ...

  1. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... provider may ask you to come into the office on different days and at different times to take your blood pressure. The health care provider also may ask you to check readings at home or at other locations that have blood pressure ...

  2. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... or focusing on something calm or peaceful Performing yoga or tai chi Meditating Medicines Blood pressure medicines work in different ways to stop or slow some of the body’s functions that cause high blood pressure. Medicines to ...

  3. Diagnosis of High Blood Pressure

    Medline Plus

    Full Text Available ... Severity and Type Your health care provider usually takes 2–3 readings at several medical appointments to diagnose high blood pressure. Using the results of your blood pressure test, your health care provider will diagnose prehypertension or ...

  4. Blood Pressure Drugs and AMD

    Science.gov (United States)

    ... Patient Stories Español Eye Health / News Research News: Blood Pressure Drugs and AMD Leer en Español: Noticias de ... also found an association between AMD and high blood pressure, but this has been inconsistent. To help clarify ...

  5. Wrinkling of Pressurized Elastic Shells

    Science.gov (United States)

    Vella, Dominic; Ajdari, Amin; Vaziri, Ashkan; Boudaoud, Arezki

    2011-10-01

    We study the formation of localized structures formed by the point loading of an internally pressurized elastic shell. While unpressurized shells (such as a ping-pong ball) buckle into polygonal structures, we show that pressurized shells are subject to a wrinkling instability. We study wrinkling in depth, presenting scaling laws for the critical indentation at which wrinkling occurs and the number of wrinkles formed in terms of the internal pressurization and material properties of the shell. These results are validated by numerical simulations. We show that the evolution of the wrinkle length with increasing indentation can be understood for highly pressurized shells from membrane theory. These results suggest that the position and number of wrinkles may be used in combination to give simple methods for the estimation of the mechanical properties of highly pressurized shells.

  6. Wrinkling of Pressurized Elastic Shells

    KAUST Repository

    Vella, Dominic

    2011-10-01

    We study the formation of localized structures formed by the point loading of an internally pressurized elastic shell. While unpressurized shells (such as a ping-pong ball) buckle into polygonal structures, we show that pressurized shells are subject to a wrinkling instability. We study wrinkling in depth, presenting scaling laws for the critical indentation at which wrinkling occurs and the number of wrinkles formed in terms of the internal pressurization and material properties of the shell. These results are validated by numerical simulations. We show that the evolution of the wrinkle length with increasing indentation can be understood for highly pressurized shells from membrane theory. These results suggest that the position and number of wrinkles may be used in combination to give simple methods for the estimation of the mechanical properties of highly pressurized shells. © 2011 American Physical Society.

  7. Pressure rig for repetitive casting

    Science.gov (United States)

    Vasquez, Peter; Hutto, William R.; Philips, Albert R.

    1989-09-01

    The invention is a pressure rig for repetitive casting of metal. The pressure rig performs like a piston for feeding molten metal into a mold. Pressure is applied to an expandable rubber diaphragm which expands like a balloon to force the metal into the mold. A ceramic cavity which holds molten metal is lined with blanket-type insulating material, necessitating only a relining for subsequent use and eliminating the lengthy cavity preparation inherent in previous rigs. In addition, the expandable rubber diaphragm is protected by the insulating material thereby decreasing its vulnerability to heat damage. As a result of the improved design the life expectancy of the pressure rig contemplated by the present invention is more than doubled. Moreover, the improved heat protection has allowed the casting of brass and other alloys with higher melting temperatures than possible in the conventional pressure rigs.

  8. Pressurized waterproof case electronic device

    KAUST Repository

    Berumen, Michael L.

    2013-01-31

    A pressurized waterproof case for an electronic device is particularly adapted for fluid-tight containment and operation of a touch-screen electronic device or the like therein at some appreciable water depth. In one example, the case may be formed as an enclosure having an open top panel or face covered by a flexible, transparent membrane or the like for the operation of the touchscreen device within the case. A pressurizing system is provided for the case to pressurize the case and the electronic device therein to slightly greater than ambient in order to prevent the external water pressure from bearing against the transparent membrane and pressing it against the touch screen, thereby precluding operation of the touch screen device within the case. The pressurizing system may include a small gas cartridge or may be provided from an external source.

  9. Organic electronics based pressure sensor towards intracranial pressure monitoring

    Science.gov (United States)

    Rai, Pratyush; Varadan, Vijay K.

    2010-04-01

    The intra-cranial space, which houses the brain, contains cerebrospinal fluid (CSF) that acts as a fluid suspension medium for the brain. The CSF is always in circulation, is secreted in the cranium and is drained out through ducts called epidural veins. The venous drainage system has inherent resistance to the flow. Pressure is developed inside the cranium, which is similar to a rigid compartment. Normally a pressure of 5-15 mm Hg, in excess of atmospheric pressure, is observed at different locations inside the cranium. Increase in Intra-Cranial Pressure (ICP) can be caused by change in CSF volume caused by cerebral tumors, meningitis, by edema of a head injury or diseases related to cerebral atrophy. Hence, efficient ways of monitoring ICP need to be developed. A sensor system and monitoring scheme has been discussed here. The system architecture consists of a membrane less piezoelectric pressure sensitive element, organic thin film transistor (OTFT) based signal transduction, and signal telemetry. The components were fabricated on flexible substrate and have been assembled using flip-chip packaging technology. Material science and fabrication processes, subjective to the device performance, have been discussed. Capability of the device in detecting pressure variation, within the ICP pressure range, is investigated and applicability of measurement scheme to medical conditions has been argued for. Also, applications of such a sensor-OTFT assembly for logic sensor switching and patient specific-secure monitoring system have been discussed.

  10. Pressurized lunar rover

    Science.gov (United States)

    Creel, Kenneth; Frampton, Jeffrey; Honaker, David; McClure, Kerry; Zeinali, Mazyar

    1992-05-01

    The pressurized lunar rover (PLR) consists of a 7 m long, 3 m diameter cylindrical main vehicle and a trailer which houses the power and heat rejection systems. The main vehicle carries the astronauts, life support systems, navigation and communication systems, directional lighting, cameras, and equipment for exploratory experiments. The PLR shell is constructed of a layered carbon-fiber/foam composite. The rover has six 1.5 m diameter wheels on the main body and two 1.5 m diameter wheels on the trailer. The wheels are constructed of composites and flex to increase traction and shock absorption. The wheels are each attached to a double A-arm aluminum suspension, which allows each wheel 1 m of vertical motion. In conjunction with a 0.75 m ground clearance, the suspension aids the rover in negotiating the uneven lunar terrain. The 15 N-m torque brushless electric motors are mounted with harmonic drive units inside each of the wheels. The rover is steered by electrically varying the speeds of the wheels on either side of the rover. The PLR trailer contains a radiosotope thermoelectric generator providing 6.7 kW. A secondary back-up energy storage system for short-term high-power needs is provided by a bank of batteries. The trailer can be detached to facilitate docking of the main body with the lunar base via an airlock located in the rear of the PLR. The airlock is also used for EVA operation during missions. Life support is a partly regenerative system with air and hygiene water being recycled. A layer of water inside the composite shell surrounds the command center. The water absorbs any damaging radiation, allowing the command center to be used as a safe haven during solar flares. Guidance, navigation, and control are supplied by a strapdown inertial measurement unit that works with the on-board computer. Star mappers provide periodic error correction.

  11. High pressure direct injection

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J. [Cummins Westport Inc., Vancouver, BC (Canada)

    2002-07-01

    A brief overview of Cummins Westport was provided, indicating that Westport originated in the 1980s through a research team at the University of British Columbia, and the hiring of the first employees began in 1996. The joint venture between Cummins and Westport was formed in March 2001. Cummins is the largest builder of commercial diesels in the world, and Westport is a small incubation technology company with emphasis on natural gas. The contribution of each company benefits the joint venture. Cummins brings traditional expertise in product and process development and distribution system, while Westport contributes new high pressure direct injection (HPDI) technology, funding and enthusiasm. The same base engine is kept and only the fuel system is changed. HPDI uses diesel cycle combustion and diesel pilot ignites natural gas. It allows for low emissions, high performance, high efficiency and economic payback. The pilot-ignited HPDI technology was explained, and its application to large class-8 trucks was discussed. The efficiency and performance of diesel engines is maintained by HPDI technology, there are 40 per cent reductions in nitrous oxide emissions, particulate matter emissions are reduced by 60 per cent, and carbon dioxide emissions are reduced by 20 per cent. A field demonstration was reviewed, and the major test at Norcal in San Francisco was discussed. The key success factors were found to be: formalized customer support plan, on-site technical support, parts availability, driver support and interaction, and training. Liquid natural gas fuel contamination was found to cause component wear. The emphasis has now been placed on three issues: injector life improvements, fuel debris and liquid natural gas pump/dome regulator life, and fuel economy improvements. The accomplishments for 2001 were identified, such as rapidly improving reliability, 17 HPDI trucks are upfit and in-service to name a few. The goals for 2002 include the placement of permanent fuel

  12. Diet, blood pressure, and multicollinearity.

    Science.gov (United States)

    Reed, D; McGee, D; Yano, K; Hankin, J

    1985-01-01

    Recent reports of an inverse association between dietary calcium intake and hypertension stimulated this analysis of the relationship of blood pressure to more than 20 dietary factors among a group of 8000 Japanese men in Hawaii. Reported intakes of potassium, calcium, protein, and milk were all inversely associated with blood pressure levels when examined one at a time while controlling for other risk factors. Alcohol intake was directly associated with blood pressure, and was treated as a confounding variable in the analysis. The association of potassium intake with blood pressure was relatively stronger than the associations for other nutrients, but the intake of potassium was so highly correlated with intakes of calcium, milk, and protein that it was not statistically possible to identify the independent association of potassium and blood pressure. Calcium intake was strongly correlated with milk and potassium intakes, and only calcium from dairy sources was associated with blood pressure. These data thus indicate that several dietary factors are inversely related to blood pressure levels independently of other risk factors such as age, body mass, and alcohol intake. The high degree of intercorrelation (multicollinearity) among these dietary factors, however, indicates that the independent role of any specific nutrient cannot be conclusively separated from the possible effects of other nutrients in this type of study.

  13. Products formed under pressurized pyrolysis

    Energy Technology Data Exchange (ETDEWEB)

    Girard, P.; Numazawa, S.; Mouras, S.; Napoli, A. [Cirad-Foret, Montpellier Cedex (France)

    1999-07-01

    Pressure is responsible for very high charcoal yields (varying from 40% to 48% depending on the raw material and process parameters). This high solid yield induces products quality changes. A primary goal of this ongoing research is to quantitatively measure the effect of process parameters (e.g., temperature, pressure) and feedstock composition (species, moisture) on the quality of pyrolysis products. Reaction pressure was achieved either by adding nitrogen into a seated reactor or by self-increase due to gas formation during load heating. Charcoal proximate and ultimate analyses have been performed. Gas and vapour analyses by GC are not completed yet and will be discussed later. The experimental results on Brazilian tropical hardwoods show the influence of the initial pressure on product quality compared with atmospheric pressure reaction. The paper will then compare and discuss results on the role of water during the reaction. Temperature and pressure profiles suggest that water has no chemical action in the reaction but allows faster pressure increase when heated. (author)

  14. Minimum miscibility pressure from EOS

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, T. [Montana Univ., Butte, MT (United States)

    2000-06-01

    Pressure is the main factor influencing the displacement efficiency of crude oil systems by gas injection. A certain minimum pressure, called Minimum Miscibility Pressure (MMP), is required in order to achieve miscible displacement. MMP is defined as the pressure at which the oil recovery versus pressure curve (generated from the slim-tube test) displays a sharp change in slope, also called the inflection point. The author described a simple, practical method that allows the MMP to be determined. The methodology involved the application of a modified version of the Peng and Robinson Equation of State, used in conjunction with a miscibility function. The Peng and Robinson Equation of State was modified by measured molecular weight and specific gravity of the heptanes-plus fraction for the determination of parameters. The necessary criteria for the prediction of the required injection pressure in miscible gas injection were taken into account in the formulation of the mathematical miscibility function. The demonstration of the use of the miscibility function for the determination of the required conditions for miscible displacement of hydrocarbon systems by gas injection was made. The author validated the methodology through a comparison with numerous experimentally measured minimum miscibility pressure values. The results indicated that the methodology presented by the author is capable of accurately predicting MMP for carbon dioxide and other gases with an absolute average error of 3.4 per cent. 32 refs., 2 tabs., 4 figs.

  15. Serotonin and Blood Pressure Regulation

    Science.gov (United States)

    Morrison, Shaun F.; Davis, Robert Patrick; Barman, Susan M.

    2012-01-01

    5-Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a substance isolated from blood. The neural effects of 5-HT have been well investigated and understood, thanks in part to the pharmacological tools available to dissect the serotonergic system and the development of the frequently prescribed selective serotonin-reuptake inhibitors. By contrast, our understanding of the role of 5-HT in the control and modification of blood pressure pales in comparison. Here we focus on the role of 5-HT in systemic blood pressure control. This review provides an in-depth study of the function and pharmacology of 5-HT in those tissues that can modify blood pressure (blood, vasculature, heart, adrenal gland, kidney, brain), with a focus on the autonomic nervous system that includes mechanisms of action and pharmacology of 5-HT within each system. We compare the change in blood pressure produced in different species by short- and long-term administration of 5-HT or selective serotonin receptor agonists. To further our understanding of the mechanisms through which 5-HT modifies blood pressure, we also describe the blood pressure effects of commonly used drugs that modify the actions of 5-HT. The pharmacology and physiological actions of 5-HT in modifying blood pressure are important, given its involvement in circulatory shock, orthostatic hypotension, serotonin syndrome and hypertension. PMID:22407614

  16. Pressure Measurement Based on Thermocouples

    Science.gov (United States)

    Thomsen, K.

    2010-12-01

    Measuring gas pressures reliably in a harsh radiation environment was confirmed to be tricky during operation of the liquid spallation target of MEGAPIE at the Paul Scherrer Institute (PSI). Severe drift of calibration and the loss of a sensor were experienced. At the same time, the only instrumentation that worked flawlessly in the system were thermocouples. Motivated by this experience, a novel pressure sensor for application in high radiation fields has been developed, which is based on temperature measurement. The new sensor takes advantage of the fact that the thermal conductivity over a mechanical joint exhibits a strong dependence on the contact pressure. In the novel sensor heating is applied at one point and temperatures are measured at different specific locations of the pressure gage; in particular, the temperatures on the two sides of a mechanical contact are monitored. From the observed temperature distribution the gas pressure can be derived. By choosing specific mechanical details in the lay-out, it is possible to tailor the useful measurement range. In addition to yielding pressure values, the new sensor concept admits for obtaining a measure for the accuracy of the result. This is done by continuous self monitoring of the device. The health status and based thereupon the plausibility of the indicated pressure value can be deducted by comparing sensed temperatures to expectation values for any given heating power. Malfunctioning of the pressure gage is reliably detected from the diverse readings of only one device; this can be seen as providing internal redundancy while at the same time immunity to common mode failure. After some analytical and finite element studies to verify the concept in principle, a first prototype of such a novel pressure sensor has been built at PSI. Initial measurement campaigns demonstrated the correct operation of the device as anticipated. Further potential for optimization, like designing a gage for high temperature

  17. 14 CFR 29.1325 - Static pressure and pressure altimeter systems.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Static pressure and pressure altimeter...: Installation § 29.1325 Static pressure and pressure altimeter systems. (a) Each instrument with static air case... between air pressure in the static pressure system and true ambient atmospheric static pressure is not...

  18. An experimental study of artificial murine bladder reflex arc established by abdominal reflex.

    Science.gov (United States)

    Wang, Jin-Wu; Zhao, Yu-Wu; Hou, Chun-Lin; Ni, Wei-Feng; Rui, Bi-Yu; Guo, Shang-Chun; Zheng, Xian-You; Dai, Ke-Rong

    2011-02-01

    The neurogenic bladder dysfunction caused by spinal cord injury is difficult to treat clinically. The aim of this research was to establish an artificial bladder reflex arc in rats through abdominal reflex pathway above the level of spinal cord injury, reinnervate the neurogenic bladder and restore bladder micturition. The outcome was achieved by intradural microanastomosis of the right T13 ventral root to S2 ventral root with autogenous nerve grafting, leaving the right T13 dorsal root intact. Long-term function of the reflex arc was assessed from nerve electrophysiological data and intravesical pressure tests during 8 months postoperation. Horseradish peroxidase (HRP) tracing was performed to observe the effectiveness of the artificial reflex. Single stimulus (3 mA, 0.3 ms pulses, 20 Hz, 5-second duration) on the right T13 dorsal root resulted in evoked action potentials, raised intravesical pressures and bladder smooth muscle, compound action potential recorded from the right vesical plexus before and after the spinal cord transaction injury between L5 and S4 segmental in 12 Sprague-Dawley rats. There were HRP labelled cells in T13 ventral horn on the experimental side and in the intermediolateral nucleus on both sides of the L6-S4 segments after HRP injection. There was no HRP labelled cell in T13 ventral horn on the control side. Using the surviving somatic reflex above the level of spinal cord injury to reconstruct the bladder autonomous reflex arc by intradural microanastomosis of ventral root with a segment of autologous nerve grafting is practical in rats and may have clinical applications for humans.

  19. Electrokinetic high pressure hydraulic system

    Science.gov (United States)

    Paul, Phillip H.; Rakestraw, David J.

    2000-01-01

    A compact high pressure hydraulic pump having no moving mechanical parts for converting electric potential to hydraulic force. The electrokinetic pump, which can generate hydraulic pressures greater than 2500 psi, can be employed to compress a fluid, either liquid or gas, and manipulate fluid flow. The pump is particularly useful for capillary-base systems. By combining the electrokinetic pump with a housing having chambers separated by a flexible member, fluid flow, including high pressure fluids, is controlled by the application of an electric potential, that can vary with time.

  20. [Diabetes Infobus 1999. Blood pressure].

    Science.gov (United States)

    Ecker, J

    2002-01-01

    In comparison to non-diabetic normotensive control subjects, hypertensive diabetic patients have a four-fold increased risk for cardiovascular morbidity and mortality. Additional to WHO/IHS definition, the terminus "high-normal blood pressure" (systolic 130-140 mm Hg and diastolic 85 - 28 kg/m2) subjects, whose percentage in our population were 32%, blood pressure was elevated (RR > 150/90) in 51%. In subclasses with high blood pressure, an increased cholesterol level was often seen; 64% of these subjects had a cholesterol level of greater 200 mg/dl.

  1. The physics of osmotic pressure

    Science.gov (United States)

    Bowler, M. G.

    2017-09-01

    Osmosis drives the development of a pressure difference of many atmospheres between a dilute solution and pure solvent with which it is in contact through a semi-permeable membrane. The educational importance of this paper is that it presents a novel treatment in terms of fluid mechanics that is quantitative and exact. It is also simple and intuitive, showing vividly how osmotic pressures are generated and maintained in equilibrium, driven by differential solvent pressures. The present rigorous analysis using the virial theorem seems unknown and can be easily understood—and taught—at various different levels. It should be valuable to undergraduates, graduate students and indeed to the general physicist.

  2. Micro packaged MEMS pressure sensor for intracranial pressure measurement

    Science.gov (United States)

    Xiong, Liu; Yan, Yao; Jiahao, Ma; Yanhang, Zhang; Qian, Wang; Zhaohua, Zhang; Tianling, Ren

    2015-06-01

    This paper presents a micro packaged MEMS pressure sensor for intracranial pressure measurement which belongs to BioMEMS. It can be used in lumbar puncture surgery to measure intracranial pressure. Miniaturization is key for lumbar puncture surgery because the sensor must be small enough to allow it be placed in the reagent chamber of the lumbar puncture needle. The size of the sensor is decided by the size of the sensor chip and package. Our sensor chip is based on silicon piezoresistive effect and the size is 400 × 400 μm2. It is much smaller than the reported polymer intracranial pressure sensors such as liquid crystal polymer sensors. In terms of package, the traditional dual in-line package obviously could not match the size need, the minimal size of recently reported MEMS-based intracranial pressure sensors after packaging is 10 × 10 mm2. In this work, we are the first to introduce a quad flat no-lead package as the package form of piezoresistive intracranial pressure sensors, the whole size of the sensor is minimized to only 3 × 3 mm2. Considering the liquid measurement environment, the sensor is gummed and waterproof performance is tested; the sensitivity of the sensor is 0.9 × 10-2 mV/kPa. Project supported by the National Natural Science Foundation of China (Nos. 61025021, 61434001), and the ‘Thousands Talents’ Program for Pioneer Researchers and Its Innovation Team, China.

  3. Laplace pressure based disjoining pressure isotherm in non symmetric conditions

    Science.gov (United States)

    Huerre, Axel; Valignat, Marie-Pierre; Maggs, A. C.; Theodoly, Olivier; Jullien, Marie-Caroline

    2017-11-01

    Understanding the stability and dynamics of two phase systems, such as foams and emulsions, in porous media is still a challenge for physicists and calls for a better understanding of the intermolecular interactions between interfaces. In a classical approach, these interactions are investigated in the framework of Derjaguin, Landau, Verwey, and Overbeek (DLVO) theory by building disjoining pressure isotherms. This paper reports on a technique allowing the measurement of disjoining pressure isotherms in a thin liquid film squeezed by either a gas or a liquid phase on a solid substrate. We couple a Reflection Interference Contrast Microscopy set-up to a microfluidic channel that sets the disjoining pressure through the Laplace pressure. This simple technique is found to be both accurate and precise. The Laplace pressure mechanism provides extremely stable conditions and offers opportunity for parallelizing experiments by producing several drops in channels of different heights. We illustrate its potential by comparing experimental isotherms for oil—[(water and sodium dodecyl sulfate (SDS)]—glass systems with different models focusing on the electrostatic contribution of the disjoining pressure. The extracted values of the interface potentials are in agreement with the constant surface potential model and with a full computation. The derived SDS surface concentration agrees with values reported in the literature. We believe that this technique is suitable for investigating other working fluids and intermolecular interactions at smaller scales.

  4. Diagnosis of High Blood Pressure

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  20. 'Peer pressure' in larval Drosophila?

    National Research Council Canada - National Science Library

    Niewalda, Thomas; Jeske, Ines; Michels, Birgit; Gerber, Bertram

    2014-01-01

    .... Here we focused in a more strict sense on 'peer pressure', that is on the question of whether the behaviour of a target individual larva is affected by what a surrounding group of larvae is doing...

  1. Diagnosis of High Blood Pressure

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    Full Text Available ... renin-angiotensin-aldosterone system makes angiotensin and aldosterone hormones . Angiotensin narrows or constricts blood vessels, which can ... pressure. Medicines Prescription medicines such as asthma or hormone therapies, including birth control pills and estrogen, and ...

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    Full Text Available ... help to lower your blood pressure. Angiotensin-Converting Enzyme (ACE) Inhibitors : Angiotensin-II is a hormone that ... and Kidney Disease (National Institute of Diabetes and Digestive and Kidney Diseases) RELATED NEWS December 13, 2017 | ...

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    Full Text Available ... NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory Committees Budget ... in the blood vessels, causing the heart to work harder and leading to high blood pressure. Medicines ...

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    Full Text Available ... such as chronic kidney disease , sleep apnea , thyroid problems, or certain tumors. This happens because these other ... blood pressure or prevent complications and long-term problems associated with this condition, such as coronary heart ...

  14. Diagnosis of High Blood Pressure

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    Full Text Available ... Science Science Home Blood Disorders and Blood Safety Sleep Science and Sleep Disorders Lung Diseases Heart and Vascular Diseases Precision ... normal for blood pressures to change when you sleep, wake up, or are excited or nervous. When ...

  15. Helping Teens Resist Sexual Pressure

    Science.gov (United States)

    ... Pediatrician Ages & Stages Prenatal Baby Toddler Preschool Gradeschool Teen Dating & Sex Fitness Nutrition Driving Safety School Substance Use Young Adult Healthy Children > Ages & Stages > Teen > Dating & Sex > Helping Teens Resist Sexual Pressure Ages & Stages Listen ...

  16. Diagnosis of High Blood Pressure

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    Full Text Available ... and adults. They use a gauge, stethoscope or electronic sensor, and a blood pressure cuff. With this ... the American College of Cardiology (ACC), the guidelines now define hypertension as a systolic blood... View all ...

  17. Diagnosis of High Blood Pressure

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    Full Text Available ... of physical activity Drinking too much alcohol Stress Family History A family history of high blood pressure ... Stroke Other Resources Many resources are available for support and to provide additional information on high blood ...

  18. Reverse Flow Pressure Limiting Aperture.

    Science.gov (United States)

    Danilatos

    2000-01-01

    The reverse flow pressure limiting aperture is a device that creates and sustains a substantial gas pressure difference between two chambers connected via an aperture. The aperture is surrounded by an annular orifice leading to a third chamber. The third chamber is maintained at a relatively high pressure that forces gas to flow through the annular aperture into the first of said two chambers. The ensuing gas flow develops into a supersonic annular gas jet, the core of which is coaxial with the central aperture. A pumping action is created at the core of the jet and any gas molecules leaking through the aperture from the second chamber are entrained and forced into the first chamber, thus creating a substantial pressure difference between the first and second chamber.

  19. Diagnosis of High Blood Pressure

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    Full Text Available ... physical activity Drinking too much alcohol Stress Family History A family history of high blood pressure raises the risk of ... Genetic causes of this condition are why family history is a risk factor for this condition. Screening ...

  20. Controlling your high blood pressure

    Science.gov (United States)

    ... medicine or your blood pressure Alternative Names Controlling hypertension ... Diabetes Association. Standards of Medical Care in Diabetes-2016 Abridged for Primary Care Providers. Clin Diabetes . 2016;34(1):3- ...

  1. Diagnosis of High Blood Pressure

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    Full Text Available ... for a certain height. Gender Before age 55, men are more likely than women to develop high ... After age 55, women are more likely than men to develop high blood pressure. Lifestyle Habits Unhealthy ...

  2. Diagnosis of High Blood Pressure

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    Full Text Available ... Are less likely to achieve target blood pressure goals with treatment. Overweight You are more likely to ... 30 or more is considered obese. A general goal to aim for is a BMI below 25. ...

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    Full Text Available ... system activity , and blood vessel structure and function. Biology and High Blood Pressure Researchers continue to study ... balances, cause your blood vessels to constrict, or impact the renin-angiotensin-aldosterone system leading to high ...

  4. Cryogenic MEMS Pressure Sensor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — A directly immersible cryogenic MEMS pressure sensor will be developed. Each silicon die will contain a vacuum-reference and a tent-like membrane. Offsetting thermal...

  5. Diagnosis of High Blood Pressure

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    Full Text Available ... of alcohol Lack of physical activity Overweight and Obesity Research studies show that being overweight or obese ... EVENT The Role of Microbiota in Blood Pressure Regulation Executive Summary June 10, 2016 Bethesda, MD The ...

  6. Diagnosis of High Blood Pressure

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    Full Text Available ... volumes and high blood pressure. Sympathetic Nervous System Activity The sympathetic nervous system has important functions in ... Drinking excess amounts of alcohol Lack of physical activity Overweight and Obesity Research studies show that being ...

  7. Diagnosis of High Blood Pressure

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    Full Text Available ... numbers are too high. Causes Changes, either from genes or the environment, in the body’s normal functions ... in families. Years of research have identified many genes and other mutations associated with high blood pressure, ...

  8. Electrokinetic high pressure hydraulic system

    Science.gov (United States)

    Paul, Phillip H.; Rakestraw, David J.; Arnold, Don W.; Hencken, Kenneth R.; Schoeniger, Joseph S.; Neyer, David W.

    2001-01-01

    An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.

  9. Diagnosis of High Blood Pressure

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    Full Text Available ... Tumblr. Share this page from the NHLBI on Twitter. Diagnosis of High Blood Pressure For most patients, ... events, activities, and resources at www.hearttruth.gov . Twitter Facebook YouTube Google+ SITE INDEX ACCESSIBILITY PRIVACY STATEMENT ...

  10. Diagnosis of High Blood Pressure

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    Full Text Available ... to the bathroom before the test. Sit for 5 minutes before the test. To track blood pressure ... and Type Your health care provider usually takes 2–3 readings at several medical appointments to diagnose ...

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    Full Text Available ... to Aim for a Healthy Weight . Limiting Alcohol Intake Limit alcohol intake. Too much alcohol will raise your blood pressure ... physically active. Maintain a healthy weight. Limit alcohol intake. Other lifestyle changes can improve your overall health, ...

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    Full Text Available ... a risk factor for this condition. Screening and Prevention Healthy lifestyle habits, proper use of medicines, and regular medical care can prevent high blood pressure or its complications. Preventing High ...

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  15. Diagnosis of High Blood Pressure

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    Full Text Available ... a period of time, the health care provider may ask you to come into the office on ... your blood pressure. The health care provider also may ask you to check readings at home or ...

  16. Diagnosis of High Blood Pressure

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    Full Text Available ... severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom number) Prehypertension ... lead to cognitive changes. Signs and symptoms include memory loss, difficulty finding words, and losing focus during ...

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  18. Diagnosis of High Blood Pressure

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  20. Diagnosis of High Blood Pressure

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    Full Text Available ... ACE inhibitors block this process, which stops the production of Angiotensin II, lowering blood pressure. Angiotensin II ... The National Heart, Lung, and Blood Institute (NHLBI) leads or sponsors many studies aimed at preventing, diagnosing, ...

  1. Diagnosis of High Blood Pressure

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  3. Diagnosis of High Blood Pressure

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  5. Diagnosis of High Blood Pressure

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    Full Text Available ... Health care workers check blood pressure readings the same way for children, teens, and adults. They use ... are outside average numbers for children of the same age, gender, and height . Once your health care ...

  6. Diagnosis of High Blood Pressure

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    Full Text Available ... pressure is a common disease in which blood flows through blood vessels (arteries) at higher than normal ... press on nearby body parts, or block blood flow. The signs and symptoms that develop depend on ...

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  8. Diagnosis of High Blood Pressure

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    Full Text Available ... may contribute to high blood pressure. The angiotensin pathway and the immune system may stiffen small and ... the renal salt regulatory and renin-angiotensin-aldosterone pathways. However, these known genetic factors only account for ...

  9. Diagnosis of High Blood Pressure

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  10. High Blood Pressure and Pregnancy

    Science.gov (United States)

    Healthy Lifestyle Pregnancy week by week High blood pressure and pregnancy isn't necessarily a dangerous combination. Here's what you ... 2017 Original article: http://www.mayoclinic.org/healthy-lifestyle/pregnancy-week-by-week/in-depth/pregnancy/art-20046098 . ...

  11. Diagnosis of High Blood Pressure

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    Full Text Available ... NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory Committees Budget ... normal for babies, while older teens have numbers similar to adults. Abnormal Blood Pressure Abnormal increases in ...

  12. Diagnosis of High Blood Pressure

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  13. Diagnosis of High Blood Pressure

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    Full Text Available ... Salt A low-sodium diet can help you manage your blood pressure. You should try to limit ... Managing and Coping With Stress Learning how to manage stress, relax, and cope with problems can improve ...

  14. Diagnosis of High Blood Pressure

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    Full Text Available ... control high blood pressure. Possible future treatments under investigation include new combination medicines, vaccines, and interventions aimed ... 2016 Bethesda, MD The NHLBI convened a working group of multidisciplinary researchers on June 10, 2016, to ...

  15. Diagnosis of High Blood Pressure

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  19. Diagnosis of High Blood Pressure

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    Full Text Available ... severity levels. Stages of High Blood Pressure in Adults Stages Systolic (top number) Diastolic (bottom number) Prehypertension ... bleed. Signs and symptoms include vision changes or blindness. Heart Attack : When the flow of oxygen-rich ...

  20. Diagnosis of High Blood Pressure

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    Full Text Available ... 2016 Bethesda, MD The NHLBI convened a working group of multidisciplinary researchers on June 10, 2016, to share current scientific k... View all events on High Blood Pressure Building 31 ...