WorldWideScience

Sample records for versatile startup reactivity

  1. Efficient Synthesis and Versatile Reactivity of Porphyrinyl Grignard Reagents

    OpenAIRE

    Fujimoto, Keisuke; Yorimitsu, Hideki; Osuka, Atsuhiro

    2014-01-01

    Iodine–magnesium exchange between iodoporphyrins and iPrMgCl·LiCl proceeded successfully without decomposition of the porphyrin core. The resulting porphyrinyl Grignard reagents are nucleophilic enough to react with various carbonyl compounds, such as aldehydes, ketones, and amides. Furthermore, the porphyrinyl Grignard reagents underwent transmetalation to afford porphyrinyl copper and zinc species of mild and unique reactivity. These could be engaged in 1, 4-addition and Negishi coupling, r...

  2. Boiler startup under conditions of convective heating of the highly reactive coal dust

    Science.gov (United States)

    Zhuikov, A. V.; Kulagin, V. A.; Baranova, M. P.; Glushkov, D. O.

    2016-12-01

    Experimental research of conditions and characteristics of ignition of the pulverized coal (with a particle size of approximately 80 μm) of different-type brown coals (1B, 2B, and 3B) during convective heating by a heated airflow (at a temperature of 425-600°C and velocity of 1-5 m/s) is carried out. The use of low-inertia thermocouples, a high-speed video camera, and dedicated software has made it possible to determine the minimum oxidizer parameters needed for coal dust ignition, and the approximation dependences of a main characteristic of the process under study―ignition delay time―on the air temperature. Results of experimental studies provide a basis for developing an optimal scheme of the boiler startup without heavy oil, which differs from the known schemes by the relatively low energy consumption for fuel-burning initiation. By example of the BKZ 75-39FB boiler, the economic usefulness of applying the boiler startup without heavy oil is shown. This scheme can be implemented using the proposed ignition burner that functions as a part of the direct system of pulverized-fuel preparation.

  3. Versatile synthesis of end-reactive polyrotaxanes applicable to fabrication of supramolecular biomaterials

    Directory of Open Access Journals (Sweden)

    Atsushi Tamura

    2016-12-01

    Full Text Available Cyclodextrin (CD-threaded polyrotaxanes (PRXs with reactive functional groups at the terminals of the axle polymers are attractive candidates for the design of supramolecular materials. Herein, we describe a novel and simple synthetic method for end-reactive PRXs using bis(2-amino-3-phenylpropyl poly(ethylene glycol (PEG-Ph-NH2 as an axle polymer and commercially available 4-substituted benzoic acids as capping reagents. The terminal 2-amino-3-phenylpropyl groups of PEG-Ph-NH2 block the dethreading of the α-CDs after capping with 4-substituted benzoic acids. By this method, two series of azide group-terminated polyrotaxanes (benzylazide: PRX-Bn-N3, phenylazide: PRX-Ph-N3, were synthesized for functionalization via click reactions. The PRX-Bn-N3 and PRX-Ph-N3 reacted quickly and efficiently with p-(tert-butylphenylacetylene via copper-catalyzed click reactions. Additionally, the terminal azide groups of the PRX-Bn-N3 could be modified with dibenzylcyclooctyne (DBCO-conjugated fluorescent molecules via a copper-free click reaction; this fluorescently labeled PRX was utilized for intracellular fluorescence imaging. The method of synthesizing end-reactive PRXs described herein is simple and versatile for the design of diverse functional PRXs and can be applied to the fabrication of PRX-based supramolecular biomaterials.

  4. Versatile supramolecular reactivity of zinc-tetra(4-pyridylporphyrin in crystalline solids: Polymeric grids with zinc dichloride and hydrogen-bonded networks with mellitic acid

    Directory of Open Access Journals (Sweden)

    Sophia Lipstman

    2009-12-01

    Full Text Available Crystal engineering studies confirm that the zinc-tetra(4-pyridylporphyrin building block reveals versatile supramolecular chemistry. In this work, it was found to be reactive in the assembly of both (a a 2D polymeric array by a unique combination of self-coordination and coordination through external zinc dichloride linkers and (b an extended heteromolecular hydrogen-bonded network with mellitic acid sustained by multiple connectivity between the component species.

  5. Versatile and Biomass Synthesis of Iron-based Nanoparticles Supported on Carbon Matrix with High Iron Content and Tunable Reactivity

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Dongmao [ORNL; Shi, Sheldon Q [ORNL; Jiang, Dongping [Mississippi State University (MSU); Che, Wen [Mississippi State University (MSU); Gai, Zheng [ORNL; Howe, Jane Y [ORNL; More, Karren Leslie [ORNL; Arockiasamy, Antonyraj [Mississippi State University (MSU)

    2012-01-01

    Iron-based nanoparticles supported on carbon (FeNPs{at}C) have enormous potential for environmental applications. Reported is a biomass-based method for FeNP{at}C synthesis that involves pyrolysis of bleached wood fiber pre-mixed with Fe{sub 3}O{sub 4} nanoparticles. This method allows synthesis of iron-based nanoparticles with tunable chemical reactivity by changing the pyrolysis temperature. The FeNP{at}C synthesized at a pyrolysis temperature of 500 C (FeNP{at}C-500) reacts violently (pyrophoric) when exposed to air, while FeNP{at}C prepared at 800 C (FeNP{at}C-800) remains stable in ambient condition for at least 3 months. The FeNPs in FeNP{at}C-800 are mostly below 50 nm in diameter and are surrounded by carbon. The immediate carbon layer (within 5-15 nm radius) on the FeNPs is graphitized. Proof-of-concept environmental applications of FeNPs{at}C-800 were demonstrated by Rhodamine 6G and arsenate (V) removal from water. This biomass-based method provides an effective way for iron-based nanoparticle fabrication and biomass utilization.

  6. Versatile and biomass synthesis of iron-based nanoparticles supported on carbon matrix with high iron content and tunable reactivity

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Dongmao, E-mail: DZ33@msstate.edu [Mississippi State University, Department of Chemistry (United States); Shi, Sheldon Q. [University of North Texas, Mechanical and Energy Engineering (United States); Pittman, Charles U.; Jiang Dongping [Mississippi State University, Department of Chemistry (United States); Che Wen [University of North Texas, Mechanical and Energy Engineering (United States); Gai Zheng; Howe, Jane Y.; More, Karren L. [Oak Ridge National Laboratory, Center for Nanophase Materials Sciences (United States); Antonyraj, Arockiasamy [Mississippi State University, Center for Advanced Vehicular Systems (United States)

    2012-08-15

    Iron-based nanoparticles supported on carbon (FeNPs-C) have enormous potential for environmental applications. Reported is a biomass-based method for FeNP-C synthesis that involves pyrolysis of bleached wood fiber pre-mixed with Fe{sub 3}O{sub 4} nanoparticles. This method allows synthesis of iron-based nanoparticles with tunable chemical reactivity by changing the pyrolysis temperature. The FeNP-C synthesized at a pyrolysis temperature of 500 Degree-Sign C (FeNP-C-500) reacts violently (pyrophoric) when exposed to air, while FeNP-C prepared at 800 Degree-Sign C (FeNP-C-800) remains stable in ambient condition for at least 3 months. The FeNPs in FeNP-C-800 are mostly below 50 nm in diameter and are surrounded by carbon. The immediate carbon layer (within 5-15 nm radius) on the FeNPs is graphitized. Proof-of-concept environmental applications of FeNPs-C-800 were demonstrated by Rhodamine 6G and arsenate (V) removal from water. This biomass-based method provides an effective way for iron-based nanoparticle fabrication and biomass utilization.

  7. Lean Startup Practice in Finland

    OpenAIRE

    Chu, Quynh

    2015-01-01

    The thesis examines the movement of lean startup phenomenon within startups in Finland. The research questions for the thesis are: “How are Lean Startups principles changing the way startups are managed?” And “Why are startups in Finland practicing lean startup principles?” The research’s target is to provide a supporting document to evaluate if Lean Startup should be consider as the management philosophy for the startups belonging to JAMK Incubator and Generator Programs. The research is ...

  8. On Startups and Doublethink

    DEFF Research Database (Denmark)

    Egan-Wyer, Carys; Muhr, Sara L.; Rehn, Alf

    2018-01-01

    Startup entrepreneurship is – in the literature, in the discourse of those engaging in it, and in cultural representations of the same – presented both as resistance against prevailing corporate logics and as a path towards becoming a corporate entity. Resistance, claimed or otherwise, is not just...... a reaction to a perceived outrage or a power imbalance, but isin itselfa constitutive part of contemporary entrepreneurship,particularly as this is culturally constructed. We study this paradox, where a discourse of resistance becomes a productive part of entrepreneurial culture, by way of a case study...... of a successful startup. We analyze the manner in which people working in the startup utilize ‘doublethink’ to portray the organization both as resistance to an assumed, more corporate, ‘Other’ and also as a budding corporation unto itself. By doing so, we highlight how a discourse of resistance works as a value...

  9. Lean start-up

    DEFF Research Database (Denmark)

    Rasmussen, Erik Stavnsager; Tanev, Stoyan

    2016-01-01

    The risk of launching new products and starting new firms is known to be extremely high. The Lean Start-up approach is a way of reducing these risks and enhancing the chances for success by validating the products and services in the market with customers before launching it in full scale. The main...... and the final business model. In other words: The start-up must first nail the problem together with the customers, then develop the solution and test, and then in the end scale it to a full-grown business model....

  10. Editorial: Startups (February 2010

    Directory of Open Access Journals (Sweden)

    Dru Lavigne

    2010-01-01

    Full Text Available Bob Sutor, Vice President of the Open Source and Linux division at IBM, recently stated that "there doesn't seem to be very many good guides about the nuts and bolts of starting an open source business". He speculates that one reason is that "there is no one way to start and run a business that involves open source". The authors in this issue of the OSBR are serial entrepreneurs, startup founders, and professionals who provide services to and interact daily with startups.

  11. Effect of startup circuit exercise on derivatives reactive oxygen metabolites, biological antioxidant potential levels and physical fitness of adolescents boys with intellectual disabilities.

    Science.gov (United States)

    Kim, Chang-Gyun; Lee, Jin-Seok

    2016-10-01

    The purpose of this study was to examine the effect of starup circuit exercise program on derivatives reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP) levels and physical fitness of adolescents with intellectual disabilities, and to sugesst exercise programs to promote the health and physical development of such adolescents. Twelve students with intellectual disabilities were divided into two groups; circuit exercise group (CE group: n=6; age, 14.83±0.98 years; height, 163.83±5.78 cm; body mass, 67.08±3.32 kg; %Fat, 25.68±2.42), control group (CON group: n=6; age: 15.00±0.63 years; height, 162.33±4.41 cm; body mass, 67.50±3.62 kg; %Fat, 26.96±2.06). The CE group performed the CE program 4 times a week over a 12-week period. The CON group maintained their activities of daily living. The following were measured before and after intervention: physical fitness by before and after the completion of the training programm, and were measured and blood samples were assessed. The results of the study indicate that the 12-week CE program increased significantly physical fitness ( P <0.05). Furthermore, This study proved that the CE program improved physical fitness, and reduced the d-ROM levels, and increased the BAP levels of the adolescents with intellectual disabilities. Therefore, it may enhance the health and physical development of adolescents boys with intellectual disabilities.

  12. Startup development: strategic point of view

    OpenAIRE

    ZOPUNYAN Y.S.

    2015-01-01

    The article analyses different strategies of the startup development. The author considers such phases of the startup development as pre-startup, launch, post-startup. The author analyzes factors that affect startup development. The paper presents conclusions about key elements of startup's strategic development.

  13. Software Startups - A Research Agenda

    Directory of Open Access Journals (Sweden)

    Michael Unterkalmsteiner

    2016-10-01

    Full Text Available Software startup companies develop innovative, software-intensive products within limited time frames and with few resources, searching for sustainable and scalable business models. Software startups are quite distinct from traditional mature software companies, but also from micro-, small-, and medium-sized enterprises, introducing new challenges relevant for software engineering research. This paper's research agenda focuses on software engineering in startups, identifying, in particular, 70+ research questions in the areas of supporting startup engineering activities, startup evolution models and patterns, ecosystems and innovation hubs, human aspects in software startups, applying startup concepts in non-startup environments, and methodologies and theories for startup research. We connect and motivate this research agenda with past studies in software startup research, while pointing out possible future directions. While all authors of this research agenda have their main background in Software Engineering or Computer Science, their interest in software startups broadens the perspective to the challenges, but also to the opportunities that emerge from multi-disciplinary research. Our audience is therefore primarily software engineering researchers, even though we aim at stimulating collaborations and research that crosses disciplinary boundaries. We believe that with this research agenda we cover a wide spectrum of the software startup industry current needs.

  14. Online communication of startups

    OpenAIRE

    Nezhybová, Linda

    2014-01-01

    This thesis deals with a plan of marketing strategy for Psaní Hravě project. The main objective is to suggest a communication strategy and show practical utilization of social media. The first chapter describes communication of successful Czech startups. The second chapter comments on possibilities of social media. Subsequently I explore utilization for brands, especially for SMEs and online projects. The third chapter introduces Psaní Hravě project, its image and target group. In the last ch...

  15. Design Thinking in Startups

    OpenAIRE

    Nguyen, Bao Marianna

    2016-01-01

    Recognizing the knowledge and opportunities that customers and users can provide, a shift toward user-centered approaches to innovation has been gaining a large interest. Design thinking has been introduced as an innovation approach that brings creativity and user-centeredness to businesses. Despite this, little attention has been given to design thinking in startups. Though design thinking has gained considerable interest, there is still a lack of empirical research and literature on how des...

  16. Human resource management in startups

    OpenAIRE

    Šumavský, Sebastián

    2015-01-01

    This bachelor thesis is focused on personnel management in small companies, startups in particular, which are companies in the state of development and market research. It deals with main personnel activities in small companies, history of startups and influence of soft factors onto it's success. In the empiric part of this thesis are presented result of an examination, which was used to explore how personnel management work in specific startup companies and how much different it is comparing...

  17. Improvement of Interfacial Adhesion by Bio-Inspired Catechol-Functionalized Soy Protein with Versatile Reactivity: Preparation of Fully Utilizable Soy-Based Film

    Directory of Open Access Journals (Sweden)

    Zhong Wang

    2017-03-01

    Full Text Available The development of materials based on renewable resources with enhanced mechanical and physicochemical properties is hampered by the abundance of hydrophilic groups because of their structural instability. Bio-inspired from the strong adhesion ability of mussel proteins, renewable and robust soy-based composite films were fabricated from two soybean-derived industrial materials: soluble soybean polysaccharide (SSPS and catechol-functionalized soy protein isolate (SPI-CH. The conjugation of SPI with multiple catechol moieties as a versatile adhesive component for SSPS matrix efficiently improved the interfacial adhesion between each segment of biopolymer. The biomimetic adherent catechol moieties were successfully bonded in the polymeric network based on catechol crosslinking chemistry through simple oxidative coupling and/or coordinative interaction. A combination of H-bonding, strong adhesion between the SPI-CH conjugation and SSPS matrix resulted in remarkable enhancements for mechanical properties. It was found that the tensile strength and Young’s modulus was improved from 2.80 and 17.24 MPa of unmodified SP film to 4.04 and 97.22 MPa of modified one, respectively. More importantly, the resultant films exhibited favorable water resistance and gas (water vapor barrier performances. The results suggested that the promising way improved the phase adhesion of graft copolymers using catechol-functionalized polymers as versatile adhesive components.

  18. FICHe Digital Health startup portfolio

    NARCIS (Netherlands)

    2016-01-01

    The FICHe (Future Internet CHallenge eHealth) project challenged European SMEs and start-ups to develop innovative applications and businesses in the eHealth market using FIWARE technology. 80 SMEs and start-ups entered the challenge and were offered mentoring, training, technical support, a real

  19. The Family Startup Program

    DEFF Research Database (Denmark)

    Trillingsgaard, Tea; Maimburg, Rikke Damkjær; Simonsen, Marianne

    2015-01-01

    . However, little is known about effect of universal approaches to parenting support during the transition to parenthood. This protocol describes and experimental evaluation of group based parenting support, the Family Startup Program (FSP), currently implemented large scale in Denmark. Methods....../design: Participants will be approximately 2500 pregnant women and partners. Inclusion criteria are parental age above 18 and the mother expecting first child. Families are recruited when attending routine pregnancy scans provided as a part of the publicly available prenatal care program at Aarhus University Hospital...... and community resources. The program consists of twelve group sessions, with nine families in each group, continuing from pregnancy until the child is 15 months old. TAU is the publicly available pre- and postnatal care available to families in both conditions. Analyses will employ survey data, administrative...

  20. Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines.

    Science.gov (United States)

    Heller, Philipp; Hobernik, Dominika; Lächelt, Ulrich; Schinnerer, Meike; Weber, Benjamin; Schmidt, Manfred; Wagner, Ernst; Bros, Matthias; Barz, Matthias

    2017-07-28

    Therapeutic nucleic acids such as pDNA hold great promise for the treatment of multiple diseases. These therapeutic interventions are, however, compromised by the lack of efficient and safe non-viral delivery systems, which guarantee stability during blood circulation together with high transfection efficiency. To provide these desired properties within one system, we propose the use of reactive triblock copolypept(o)ides, which include a stealth-like block for efficient shielding, a hydrophobic block based on reactive disulfides for cross-linking and a cationic block for complexation of pDNA. After the complexation step, bifunctional cross-linkers can be employed to bio-reversibly stabilize derived polyplexes by disulfide bond formation and to introduce endosomolytic moieties at the same time. Cross-linked polyplexes show no aggregation in human blood serum. Upon cellular uptake and cleavage of disulfide bonds, the cross-linkers can interact with the endosomal membrane, leading to lysis and efficient endosomal translocation. In principal, the approach allows for the combination of one polymer with various different cross-linkers and thus enables the fast forward creation of a polyplex library. Here, we provide a first insight into the potential of this concept and use a screening strategy to identify a lead candidate, which is able to transfect dendritic cells with a model DNA vaccine. Copyright © 2017. Published by Elsevier B.V.

  1. Startup, Shutdown, & Malfunction (SSM) Emissions

    Science.gov (United States)

    EPA issued a final action to ensure states have plans in place that are fully consistent with the Clean Air Act and recent court decisions concerning startup, shutdown and malfunction (SSM) operations.

  2. Benchmark problems of start-up core physics of High Temperature Engineering Test Reactor (HTTR)

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, Kiyonobu; Nojiri, Naoki; Fujimoto, Nozomu; Nakano, Masaaki; Ando, Hiroei; Nagao, Yoshiharu; Nagaya, Yasunobu; Akino, Fujiyosi; Takeuchi, Mituo; Fujisaki, Shingo; Shiozawa, Shusaku [Japan Atomic Energy Research Institute JAERI, Ibaraki-ken (Japan)

    1998-09-01

    The experimental data of the HTTRs start-up core physics are useful to verify design codes of commercial HTGRs due to the similarities in the core size and excess reactivity. Form these viewpoints, it is significant to carry out the bench mark tests of design codes by using data of start-up core physics experiments planned for the HTTR. The evaluations of the first criticality, excess reactivity of annular cores, etc., are proposed for the benchmark problem. It was found from our precalculations that diffusion calculations provide larger excess reactivity and small number of fuel columns for the first criticality than Monte Carlo calculations. 19 refs.

  3. MODEL OF IT-STARTUPS MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Ольга Андреевна КОЗИНА

    2017-03-01

    Full Text Available Decrease mortality of startups during first three years of existing is an important task of the economy of any country. It has been established that the existing methods of enterprise management have some disadvantages or limits for using in IT-startups management. Analysis of mortality reasons of startups in different stages of their life cycle has been carried out. The comparing of reasons why startups in different time intervals, in different areas of them functioning are failure showed that the run out of cash and the use of not viable business model have appeared mortality factors most often denoted by ex-leaders of startups. The model of startup management based on the lean startup model has been developed. Steps for the management of startups along first two stages of their life cycle were added. We noted that it is important to select set of static points and changeable points of startup during the process of formulation of the business model. Steps to reduce the number of iterations in the method of the lean startup are proposed.

  4. An enhanced tokamak startup model

    Science.gov (United States)

    Goswami, Rajiv; Artaud, Jean-François

    2017-01-01

    The startup of tokamaks has been examined in the past in varying degree of detail. This phase typically involves the burnthrough of impurities and the subsequent rampup of plasma current. A zero-dimensional (0D) model is most widely used where the time evolution of volume averaged quantities determines the detailed balance between the input and loss of particle and power. But, being a 0D setup, these studies do not take into consideration the co-evolution of plasma size and shape, and instead assume an unchanging minor and major radius. However, it is known that the plasma position and its minor radius can change appreciably as the plasma evolves in time to fill in the entire available volume. In this paper, an enhanced model for the tokamak startup is introduced, which for the first time takes into account the evolution of plasma geometry during this brief but highly dynamic period by including realistic one-dimensional (1D) effects within the broad 0D framework. In addition the effect of runaway electrons (REs) has also been incorporated. The paper demonstrates that the inclusion of plasma cross section evolution in conjunction with REs plays an important role in the formation and development of tokamak startup. The model is benchmarked against experimental results from ADITYA tokamak.

  5. Preliminary analyses for HTTR`s start-up physics tests by Monte Carlo code MVP

    Energy Technology Data Exchange (ETDEWEB)

    Nojiri, Naoki [Science and Technology Agency, Tokyo (Japan); Nakano, Masaaki; Ando, Hiroei; Fujimoto, Nozomu; Takeuchi, Mitsuo; Fujisaki, Shingo; Yamashita, Kiyonobu

    1998-08-01

    Analyses of start-up physics tests for High Temperature Engineering Test Reactor (HTTR) have been carried out by Monte Carlo code MVP based on continuous energy method. Heterogeneous core structures were modified precisely, such as the fuel compacts, fuel rods, coolant channels, burnable poisons, control rods, control rod insertion holes, reserved shutdown pellet insertion holes, gaps between graphite blocks, etc. Such precise modification of the core structures was difficult with diffusion calculation. From the analytical results, the followings were confirmed; The first criticality will be achieved around 16 fuel columns loaded. The reactivity at the first criticality can be controlled by only one control rod located at the center of the core with other fifteen control rods fully withdrawn. The excess reactivity, reactor shutdown margin and control rod criticality positions have been evaluated. These results were used for planning of the start-up physics tests. This report presents analyses of start-up physics tests for HTTR by MVP code. (author)

  6. Power plant start-up demands productive methods and practices

    Energy Technology Data Exchange (ETDEWEB)

    Follett, R.E.

    1993-05-01

    This article examines the factors affecting power plant start-up. The article addresses cogeneration plants in particular. The topics of the article include the start-up schedule, start-up program administration, safety tagging procedure, system boundary identification, mechanical test procedures, electrical test procedures, pre-operational tests, loop calibration reports, performance test procedure, instrument calibration, checkout philosophy, plant start-up organization, plant start-up sequence, operator training, and typical plant start-up conditions.

  7. Lean and global technology start-ups

    DEFF Research Database (Denmark)

    Tanev, Stoyan; Rasmussen, Erik Stavnsager; Zijdemans, Erik

    2015-01-01

    In this paper the authors introduce the concept of Lean Global Start-up (LGS) as a way of emphasizing the impossibility for new technology start-ups to deal separately with business development, innovation and early internationalization. For a newly established technology firm the task of being...

  8. 20 CFR 632.254 - Program startup.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Program startup. 632.254 Section 632.254 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR INDIAN AND NATIVE AMERICAN EMPLOYMENT AND TRAINING PROGRAMS Summer Youth Employment and Training Programs § 632.254 Program startup...

  9. When Do Start-Ups Make Sense?

    Science.gov (United States)

    Langemeyer, Clement J.

    2005-01-01

    The start-up has received considerable attention in the last few years. While the National Research Council of Canada has generated many start-ups over its 88-year history, the creation of a formal entrepreneurship programme in the mid-1990s dramatically accelerated the pace at which they were created. Many factors come into play in the decision…

  10. Startup Report for Ground Water Extraction, Treatment, and Recharge System

    National Research Council Canada - National Science Library

    Lamb, Steve

    1997-01-01

    The document presents startup procedures, observations and measurements conducted during the startup of the Groundwater Extraction, Treatment and Recharge System, built for the 162nd Fighter Wing, Air...

  11. Entrepreneurial patent management in pharmaceutical startups.

    Science.gov (United States)

    Holgersson, Marcus; Phan, Tai; Hedner, Thomas

    2016-07-01

    Startups fill an increasingly important role as innovators in the pharmaceutical industry, and patenting is typically central to their success. This article aims to explore patent management in pharmaceutical startups. The results show that startups need to deal with several challenges related to patenting and an 'entrepreneurial' approach to patent management is called for. Resource constraints, venture capital provision, exits and other conditions and events must be readily considered in the patent management process to build a successful pharmaceutical venture, something that could benefit the pharmaceutical industry as a whole. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. 40 CFR 63.1111 - Startup, shutdown, and malfunction.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Startup, shutdown, and malfunction. 63... Control Technology Standards § 63.1111 Startup, shutdown, and malfunction. (a) Startup, shutdown, and... develop a written startup, shutdown, and malfunction plan that describes, in detail, procedures for...

  13. Negishi Cross-Coupling Is Compatible with a Reactive B-Cl Bond: Development of a Versatile Late-Stage Functionalization of 1,2-Azaborines and Its Application to the Synthesis of New BN Isosteres of Naphthalene and Indenyl.

    Science.gov (United States)

    Brown, Alec N; Li, Bo; Liu, Shih-Yuan

    2015-07-22

    The compatibility of the Negishi cross-coupling reaction with the versatile B-Cl functionality has been demonstrated in the context of late-stage functionalization of 1,2-azaborines. Alkyl-, aryl-, and alkenylzinc reagents have been utilized for the functionalization of the triply orthogonal precursor 3-bromo-1-(tert-butyldimethylsilyl)-2-chloro-1,2-dihydro-1,2-azaborine (2) to furnish new 2,3-substituted monocyclic 1,2-azaborines. This methodology has enabled the synthesis of previously elusive BN-naphthalene and BN-indenyl structures from a common intermediate.

  14. Is There a Lean Future for Global Startups?

    OpenAIRE

    Stoyan Tanev

    2017-01-01

    This article integrates insights from the latest research on the lean startup entrepreneurial method, born-global firms, and global startups. It contributes to the clarification of terminology referring to the global aspects of startups, summarizes insights from previous literature focusing on global startups, and further substantiates the articulation of the need for considering the lean global startup as a new type of firm. The main message is that the lessons learned from the emergence of ...

  15. Versatility of microbial transglutaminase.

    Science.gov (United States)

    Strop, Pavel

    2014-05-21

    Although microbial transglutaminases (mTGs) were initially discovered to offset the cost of producing mammalian transglutaminases for food applications, they have quickly become important tools in research and biotechnology. Today, mTGs are utilized for a large number of applications to conjugate proteins and peptides to small molecules, polymers, surfaces, and DNA, as well as to other proteins. It is important to know how to maximize the advantages of the enzymatic approach and avoid undesired cross-linking. This review focuses on the versatility of transglutaminases in the field of bioconjugation and covers recent developments in utilizing mTG for generating antibody drug conjugates (ADCs) for therapeutic applications.

  16. Reconstruction of recycling flux from synthetic camera images, evaluated for the Wendelstein 7-X startup limiter

    Science.gov (United States)

    Frerichs, H.; Effenberg, F.; Feng, Y.; Schmitz, O.; Stephey, L.; Reiter, D.; Börner, P.; The W7-X Team

    2017-12-01

    The interpretation of spectroscopic measurements in the edge region of high-temperature plasmas can be guided by modeling with the EMC3-EIRENE code. A versatile synthetic diagnostic module, initially developed for the generation of synthetic camera images, has been extended for the evaluation of the inverse problem in which the observable photon flux is related back to the originating particle flux (recycling). An application of this synthetic diagnostic to the startup phase (inboard) limiter in Wendelstein 7-X (W7-X) is presented, and reconstruction of recycling from synthetic observation of \\renewcommand{\

  17. DISP: Optimizations towards Scalable MPI Startup

    Energy Technology Data Exchange (ETDEWEB)

    Fu, Huansong [Florida State University, Tallahassee; Pophale, Swaroop S [ORNL; Gorentla Venkata, Manjunath [ORNL; Yu, Weikuan [Florida State University, Tallahassee

    2016-01-01

    Despite the popularity of MPI for high performance computing, the startup of MPI programs faces a scalability challenge as both the execution time and memory consumption increase drastically at scale. We have examined this problem using the collective modules of Cheetah and Tuned in Open MPI as representative implementations. Previous improvements for collectives have focused on algorithmic advances and hardware off-load. In this paper, we examine the startup cost of the collective module within a communicator and explore various techniques to improve its efficiency and scalability. Accordingly, we have developed a new scalable startup scheme with three internal techniques, namely Delayed Initialization, Module Sharing and Prediction-based Topology Setup (DISP). Our DISP scheme greatly benefits the collective initialization of the Cheetah module. At the same time, it helps boost the performance of non-collective initialization in the Tuned module. We evaluate the performance of our implementation on Titan supercomputer at ORNL with up to 4096 processes. The results show that our delayed initialization can speed up the startup of Tuned and Cheetah by an average of 32.0% and 29.2%, respectively, our module sharing can reduce the memory consumption of Tuned and Cheetah by up to 24.1% and 83.5%, respectively, and our prediction-based topology setup can speed up the startup of Cheetah by up to 80%.

  18. Applying technical versatility

    Energy Technology Data Exchange (ETDEWEB)

    None

    1970-01-01

    The breadth and depth of the diversified technical programs at Mound Laboratory since its inception are characterized by a record of competence and versatility during the past generation. A spectrum of mission assignments has been completed successfully in such diverse technical areas as process development and manufacturing of explosive components, research on fuels for the Civilian Power Reactor Program, separation of radioactive materials, fabrication of radioisotopic heat sources, stable gaseous isotope separation and purification, and many other areas. Mound Laboratory is one of the key U.S. Atomic Energy Commission sites that has demonstrated its technical competence in both weapons and non-weapons activities. This report has been prepared to complement the AEC’s vigorous program of scientific information dissemination. Three broad areas of technical competence are highlighted here: explosive technology, radionuclide technology, and stable gaseous isotope separation, which encompass a broad variety of techniques and supporting disciplines.

  19. Holographic versatile disc system

    Science.gov (United States)

    Horimai, Hideyoshi; Tan, Xiaodi

    2005-09-01

    A Holographic Versatile Disc (HVD) system, using Collinear Technologies for a high capacity and high data transfer rates storage system, is proposed. With its unique configuration the optical pickup can be designed as small as a DVD's, and can be placed on one side of the disc. With the HVD's special structure, the system can servo the focus/track and locate reading/writing address. A unique selectable capacity recording format of HVD and its standardization activity are also introduced. Experimental and theoretical studies suggest that the tilt, wavelength, defocus and de-track margins are wide enough to miniaturize the HVD system at a low cost. HVD systems using Collinear Technologies will be compatible with existing disc storage systems, like CD and DVD, and will enable us to expand its applications into other optical information storage systems.

  20. Versatile by design

    CERN Multimedia

    Katarina Anthony

    2014-01-01

    CHARM (CERN High energy AcceleRator Mixed field) is a new and unique testing facility that will complete CERN's radiation testing installations. Located in the East Area, CHARM will provide teams with a venue to test their equipment in radiation environments similar to those found in the accelerator chain.   Team at work in the irradiation zone of the CHARM facility. First envisaged in 2007, the CHARM facility fulfils a growing demand for a large-scale tailor-made radiation testing facility. Unlike commercial facilities, CHARM features a wide spectrum of radiation types and energies (called mixed-field radiation environments), the space to test large equipment and even the possibility to adjust the environment using mobile shielding. "CHARM is versatile by design, allowing us to recreate any of the radiation environments found in the accelerator chain," says Markus Brugger, head of the R2E (Radiation to Electronics) project team that developed the CHARM facility. &a...

  1. Company start-up costs and employment

    OpenAIRE

    Christopher Pissarides

    2002-01-01

    I study the role of company start-up costs for employment performance. The model is search equilibrium with a new concept for firms. Agents have an innate managerial ability and make a career choice to become either managers or workers. Managers set up firms, post jobs and match with workers. Managers set up firms, post jobs and match with workers. I show that in equilibrium, career choice and job creation are jointly determined. Higher start-up costs reduce overall employment but increase th...

  2. Smart or Diverse Start-up Teams?

    DEFF Research Database (Denmark)

    Hoogendoorn, Sander; Parker, Simon C.; Van Praag, Mirjam

    2017-01-01

    This paper explores the relationship between cognitive abilities and team performance in a start-up setting. We argue that performance in this setting hinges on three tasks: opportunity recognition, problem solving, and implementation. We theorize that cognitive ability at the individual level has...... by assigning students to teams based on their measured cognitive abilities. Each team performed a variety of tasks, often involving complex decision making. The key result of the experiment is that the performance of start-up teams first increases and then decreases with ability dispersion. Strikingly, average...

  3. The Lean and Global Start-up

    DEFF Research Database (Denmark)

    Tanev, Stoyan; Rasmussen, Erik Stavnsager

    For several decades researchers have studied start-up companies with a focus on international markets, suppliers and networks from their inception and on companies that are establishing new, agile business models. This has resulted in two streams of research: The Born Global and International New...... Ventures research and research with a focus on the Lean Start-up company. It is our intention in this paper to give a short presentation of the two research streams and show how they can be merged into one with a focus on newly established technology oriented firms that are lean and global from...

  4. Rent seeking and entrepreneurship: internet startups in China

    National Research Council Canada - National Science Library

    Chen, Tain-Jy; Ku, Ying-Hua

    2016-01-01

      According to Atomico (2015), which tracked venture capital (VC)-funded startups in the world, there were 156 Internet startups that had been founded in 2003-14 and that had become billion-dollar companies...

  5. Analisis Faktor Keberhasilan SDM Startup yang Ada di YOGYAKARTA

    OpenAIRE

    Jaya, Mardi Arya; Ferdiana, Ridi; Fauziati, Silmi

    2017-01-01

    Kemajuan teknologi yang semakin pesat menyebabkan banyak startup baru muncul, banyak yang berhasil tetapi tidak sedikit yang gagal dan harus gulung tikar, berdasarkan survey dari majalah forbes 90% startup didunia gagal mengembangkan startupnya, banyak faktor yang mempengaruhi kesuksesan startup salah satunya adalah SDM, tetapi masih sedikit pelaku startup yang peduli tentang faktor SDM, oleh karena itu penelitian ini dilakukan untuk mengetahui faktor apa saja yang mempengaruhi kesuksesan SDM...

  6. 40 CFR 52.271 - Malfunction, startup, and shutdown regulations.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Malfunction, startup, and shutdown..., startup, and shutdown regulations. (a) The following regulations are disapproved because they would permit... malfunctions and/or fail to sufficiently limit startup and shutdown exemptions to those periods where it is...

  7. 40 CFR 61.09 - Notification of startup.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Notification of startup. 61.09 Section...) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS General Provisions § 61.09 Notification of startup. (a) The owner or operator of each stationary source which has an initial startup after the effective...

  8. 40 CFR 68.77 - Pre-startup review.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Pre-startup review. 68.77 Section 68...) CHEMICAL ACCIDENT PREVENTION PROVISIONS Program 3 Prevention Program § 68.77 Pre-startup review. (a) The owner or operator shall perform a pre-startup safety review for new stationary sources and for modified...

  9. 40 CFR 63.1272 - Startups, shutdowns, and malfunctions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Startups, shutdowns, and malfunctions... Facilities § 63.1272 Startups, shutdowns, and malfunctions. (a) The provisions set forth in this subpart shall apply at all times except during startups or shutdowns, during malfunctions, and during periods of...

  10. 40 CFR 63.762 - Startups, shutdowns, and malfunctions.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Startups, shutdowns, and malfunctions... Facilities § 63.762 Startups, shutdowns, and malfunctions. (a) The provisions set forth in this subpart shall apply at all times except during startups or shutdowns, during malfunctions, and during periods of non...

  11. Trypanosomes - versatile microswimmers

    Science.gov (United States)

    Krüger, Timothy; Engstler, Markus

    2016-11-01

    Evolution has generated a plethora of flagellate microswimmers. They populate all natural waters, from the deep sea to the ponds in our neighbourhood. But flagellates also thrive in the bodies of higher organisms, where they mostly remain undetected, but can also become pathogenic. Trypanosomes comprise a large group of mostly parasitic flagellates that cause many diseases, such as human sleeping sickness or the cattle plague nagana. We consider African trypanosomes as extremely versatile microswimmers, as they have to adapt to very diverse microenvironments. They swim efficiently in the blood of their mammalian hosts, but also in various tissue spaces and even in the human brain. Furthermore, in the transmitting tsetse fly, trypanosomes undergo characteristic morphological changes that are accompanied by amazing transitions between solitary and collective types of motion. In this review, we provide a basic introduction to trypanosome biology and then focus on the complex type of rotational movement that trypanosomes display. We relate their swimming performance to morphological parameters and the respective microenvironment, developing a contemporary view on the physics of trypanosome motility. The genetically programmed successions of life style-dependent motion patterns provide challenges and opportunities for interdisciplinary studies of microswimmers.

  12. Startup - Philippines Community Electronic Centres Academy | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Startup - Philippines Community Electronic Centres Academy. The Philippines telecentre movement has gathered momentum in recent years, mainly due to the Philippines Community e-Centres Network (PhilCeCNet) developed with financial and technical support from IDRC's telecentre.org under project 104285. Over 800 ...

  13. From Jam to Start-up

    DEFF Research Database (Denmark)

    Bering Kjæhr, Emil; Lyngbye Hvid Jensen, Jane; Schoenau-Fog, Henrik

    2015-01-01

    the foundation for new start-up companies. There are, however, an even larger group of very creative and innovative games and artifacts with great potential that go unpublished. This potentially leads to a loss of entrepreneurial opportunities and ultimately the jobs and careers such games could have fostered...

  14. Startup Hopefuls Test Their Ideas with Educators

    Science.gov (United States)

    Tomassini, Jason

    2012-01-01

    "Educator day" is one of the most important and nerve-racking for the people taking part in Imagine K12, the biggest incubator program in the United States specifically for education technology startups. Many entrepreneurs in K-12 believe technology can solve education's problems, but don't work to understand those problems before prescribing…

  15. Start-up incentives the Netherlands

    NARCIS (Netherlands)

    Bekker, S.; van den Eijnden, J.

    2014-01-01

    Generally, there are three different types of start-up incentive for unemployed and inactive people in the Netherlands. The first is a set of incentives for potential entrepreneurs receiving Unemployment Benefits (UB) (Werloosheidwet - WW). Such incentives have existed since 2006 and were adjusted

  16. Tokamak startup with electron cyclotron heating

    Energy Technology Data Exchange (ETDEWEB)

    Holly, D J; Prager, S C; Shepard, D A; Sprott, J C

    1980-04-01

    Experiments are described in which the startup voltage in a tokamak is reduced by approx. 60% by the use of a modest amount of electron cyclotron resonance heating power for preionization. A 50% reduction in volt-second requirement and impurity reflux are also observed.

  17. Developing a Lean Startup Plan for Online Business

    OpenAIRE

    Myllykoski, Mari

    2015-01-01

    The purpose of this thesis was to develop a lean startup plan for an online company Kiddsafe Ltd. The company is a UK based startup company selling children’s locator devices, which resemble wristbands. The lean startup plan aimed to validate the bu-siness idea of the company by using practical methods of testing as defined in the lean startup methodology. The design and tactics of the research methods used were those defined by the lean startup methodology itself. The aim was to build a lean...

  18. Lean Startup: A success factor? A quantitative study of how use of the Lean Startup framework affects the success of Norwegian high-tech startups.

    OpenAIRE

    Ramm, Nicolay Arguillere

    2015-01-01

    Lean Startup is a framework for entrepreneurship that has gained considerable popularity among entrepreneurs, yet the framework has not been thoroughly scrutinized in academic circles. This thesis aims to fill this gap in two ways. First, by comparing Lean Startup to more established models on entrepreneurship in a theoretical perspective. Second, by conducting an empirical study of how Lean Startup influences entrepreneurial success in practice. In our theoretical review, we found that while...

  19. Is there a lean future for global startups?

    DEFF Research Database (Denmark)

    Tanev, Stoyan

    2017-01-01

    This article integrates insights from the latest research on the lean startup entrepreneurial method, born-global firms, and global startups. It contributes to the clarification of terminology referring to the global aspects of startups, summarizes insights from previous literature focusing...... on global startups, and further substantiates the articulation of the need for considering the lean global startup as a new type of firm. The main message is that the lessons learned from the emergence of lean startup entrepreneurship offer a basis for promoting a similar lean phase in technology......-based global startup research and practice. The analysis should benefit both researchers and practitioners in technology entrepreneurship, international entrepreneurship, and global innovation management....

  20. Is There a Lean Future for Global Startups?

    Directory of Open Access Journals (Sweden)

    Stoyan Tanev

    2017-05-01

    Full Text Available This article integrates insights from the latest research on the lean startup entrepreneurial method, born-global firms, and global startups. It contributes to the clarification of terminology referring to the global aspects of startups, summarizes insights from previous literature focusing on global startups, and further substantiates the articulation of the need for considering the lean global startup as a new type of firm. The main message is that the lessons learned from the emergence of lean startup entrepreneurship offer a basis for promoting a similar lean phase in technology-based global startup research and practice. The analysis should benefit both researchers and practitioners in technology entrepreneurship, international entrepreneurship, and global innovation management.

  1. Versatile Wireless Data Net Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed R&D is to develop a wireless data networking capability. A prototype capability will result from the Phase 1 and 2 contracts. The Versatile Wireless...

  2. DVD - digital versatile disks

    Energy Technology Data Exchange (ETDEWEB)

    Gaunt, R.

    1997-05-01

    An international standard has emerged for the first true multimedia format. Digital Versatile Disk (by its official name), you may know it as Digital Video Disks. DVD has applications in movies, music, games, information CD-ROMS, and many other areas where massive amounts of digital information is needed. Did I say massive amounts of data? Would you believe over 17 gigabytes on a single piece of plastic the size of an audio-CD? That`s the promise, at least, by the group of nine electronics manufacturers who have agreed to the format specification, and who hope to make this goal a reality by 1998. In this major agreement, which didn`t come easily, the manufacturers will combine Sony and Phillip`s one side double-layer NMCD format with Toshiba and Matsushita`s double sided Super-Density disk. By Spring of this year, they plan to market the first 4.7 gigabyte units. The question is: Will DVD take off? Some believe that read-only disks recorded with movies will be about as popular as video laser disks. They say that until the eraseable/writable DVD arrives, the consumer will most likely not buy it. Also, DVD has a good market for replacement of CD- Roms. Back in the early 80`s, the international committee deciding the format of the audio compact disk decided its length would be 73 minutes. This, they declared, would allow Beethoven`s 9th Symphony to be contained entirely on a single CD. Similarly, today it was agreed that playback length of a single sided, single layer DVD would be 133 minutes, long enough to hold 94% of all feature-length movies. Further, audio can be in Dolby`s AC-3 stereo or 5.1 tracks of surround sound, better than CD-quality audio (16-bits at 48kHz). In addition, there are three to five language tracks, copy protection and parental ``locks`` for R rated movies. DVD will be backwards compatible with current CD-ROM and audio CD formats. Added versatility comes by way of multiple aspect rations: 4:3 pan-scan, 4:3 letterbox, and 16:9 widescreen. MPEG

  3. Growth Hacking for Startups : How Growth Hacking can utilised for growing startups

    OpenAIRE

    Lee, Jin

    2016-01-01

    In the era of start-ups, many failed to put out their prototypes or products to the market due to lack of funds or experience in marketing. Growth Hacking is a tool that start-ups can benefit from if they learn what Growth Hacking is and how to implement it. The aim of this thesis is to explore what Growth Hacking is and how to implement it for the commissioner CubiCasa Oy. A couple of Growth Hacking tactics are used for CubiCasa Oy and the process of implementation and findings are rec...

  4. Temperature characterization of versatile transceivers

    CERN Document Server

    Olanterä, L.; Storey, S; Sigaud, C; Soos, C; Troska, J; Vasey, F

    2013-01-01

    The Versatile Transceiver is a part of the Versatile Link project, which is developing optical link architectures and components for future HL-LHC experiments. While having considerable size and weight constraints, Versatile Transceivers must work under severe environmental conditions. One such environmental parameter is the temperature: the operating temperature range is specified to be from -30 to +60°C. In this contribution we present the results of the temperature characterization of the VTRx transmitter and receiver. Several transmitter candidates from three different manufacturers have been characterized: multi-mode Vertical Cavity Surface-Emitting Lasers and a single-mode Edge-Emitter Laser. Also both single- and multi-mode receivers have been tested.

  5. Plasma Current Start-up in a Spherical Tokamak

    Science.gov (United States)

    Mitarai, Osamu; Kessel, Charles; Hirose, Akira

    The various plasma current start-up techniques and related topics in a spherical tokamak (ST) device are described. The Ohmic heating coil current clamp experiments in NSTX are described and discussed, and the plasma current start-up experiments in the STOR-M tokamak with iron core and the outer vertical field coil is presented as one of technique for a plasma current start-up in a ST.

  6. Learning in the business start-up process

    OpenAIRE

    Niels Bosma; Joris Meijaard; Gijs van Popta

    2002-01-01

    The start-up process is an important source for learning opportunities. The present study investigates different types of entrepreneurial learning in the start-up process. Combining contributions from psychology, sociology, organisational and entrepreneurship literature, an appropriate conceptual framework emerges, in which different types of entrepreneurial learning are distinguished. Based on this framework, and using panel data on start-up entrepreneurs, we empirically rediscovered this ty...

  7. Start-up Financing Choice and Post-entry Performance

    OpenAIRE

    Kenji Kutsuna; Yuji Honjo

    2006-01-01

    Using an original data set of start-up firms in Japan, this paper investigates whether post-entry performance differs between start-up firms, according to the source of finance. In particular, the difference among firms that used entrepreneur' s own savings (insider finance), bank borrowing, and risk capital from business angels or venture capital firms is focused upon. It is found that start-up firms financed by business angels are more likely to increase sales even after controlling entrepr...

  8. Start-up financing in the age of Globalisation

    OpenAIRE

    Korosteleva, J.; Mickiewicz, T.

    2010-01-01

    We investigate the determinants of start-up financing in 54 countries, using the Global Entrepreneurship Monitor (GEM) surveys for years 2001-2006. We find that financial liberalisation increases the total financial size of the individual start-up entrepreneurial project both via the increased use of external and of own funds. In addition, the volume of start-up finance responds positively to international capital inflows as represented by loans from non-resident banks and remittances, and ne...

  9. Start-up financing:a comparative perspective

    OpenAIRE

    Korosteleva, Julia; Mickiewicz, Tomasz

    2008-01-01

    We investigate the determinants of start-up financing in 41 countries, using the Global Entrepreneurship Monitor surveys for 1998-20032. High quality of property rights increases both the total volume of finance and the use of external finance for the individual start-up. The size of the formal financial sector affects the start-up finance via enhancing the volume of self-finance. In addition, the use of external finance by start-ups correlates with the extent of financial restrictions in a c...

  10. Replacement of Cross-Site Transfer System Startup Plan

    Energy Technology Data Exchange (ETDEWEB)

    Gerken, M.D.

    1996-01-01

    This Startup Plan provides a discussion of organizational responsibilities, work planning, quality assurance (QA), personnel qualifications, and testing requirements for the Cross-Site Transfer System.

  11. Xanthan-A Versatile Gum

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 9; Issue 10. Xanthan – A Versatile Gum. Anil Lachke. General Article Volume 9 Issue 10 October 2004 pp 25-33. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/009/10/0025-0033. Keywords. Xanthan ...

  12. 75 FR 68989 - Approval and Promulgation of Implementation Plans; Texas; Excess Emissions During Startup...

    Science.gov (United States)

    2010-11-10

    ... Startup, Shutdown, Maintenance, and Malfunction Activities AGENCY: Environmental Protection Agency (EPA... Scheduled Maintenance, Startup, and Shutdown Activities. We are finalizing our proposed approval of those... against civil penalties for excess emissions during planned maintenance, startup, or shutdown activities...

  13. 75 FR 26892 - Approval and Promulgation of Implementation Plans; Texas; Excess Emissions During Startup...

    Science.gov (United States)

    2010-05-13

    ... Startup, Shutdown, Maintenance, and Malfunction Activities AGENCY: Environmental Protection Agency (EPA... A General Rules; and Subchapter F Emissions Events and Scheduled Maintenance, Startup, and Shutdown... penalties for excess emissions during planned maintenance, startup, or shutdown activities. A disapproval of...

  14. Reactor power system deployment and startup

    Science.gov (United States)

    Wetch, J. R.; Nelin, C. J.; Britt, E. J.; Klein, G.

    1985-01-01

    This paper addresses issues that should receive further examination in the near-term as concept selection for development of a U.S. space reactor power system is approached. The issues include: the economics, practicality and system reliability associated with transfer of nuclear spacecraft from low earth shuttle orbits to operational orbits, via chemical propulsion versus nuclear electric propulsion; possible astronaut supervised reactor and nuclear electric propulsion startup in low altitude Shuttle orbit; potential deployment methods for nuclear powered spacecraft from Shuttle; the general public safety of low altitude startup and nuclear safe and disposal orbits; the question of preferred reactor power level; and the question of frozen versus molten alkali metal coolant during launch and deployment. These issues must be considered now because they impact the SP-100 concept selection, power level selection, weight and size limits, use of deployable radiators, reliability requirements, and economics, as well as the degree of need for and the urgency of developing space reactor power systems.

  15. Social capital of venture capitalists and start-up funding

    NARCIS (Netherlands)

    O.T. Alexy (Oliver); J.H. Block (Jörn); P.G. Sandner (Philipp); A.L.J. Ter Wal (Anne)

    2012-01-01

    textabstractHow does the social capital of venture capitalists (VCs) affect the funding of start-ups? By building on the rich social capital literature, we hypothesize a positive effect of VCs' social capital, derived from past syndication, on the amount of money that start-ups receive.

  16. Genetic Counselors in Startup Companies: Redefining the Genetic Counselor Role.

    Science.gov (United States)

    Rabideau, Marina M; Wong, Kenny; Gordon, Erynn S; Ryan, Lauren

    2016-08-01

    Genetic counselors (GCs) have recently begun moving into non-clinic based roles in increasing numbers. A relatively new role for GCs is working for startup companies. Startups are newly established companies in the phase of developing and researching new scalable businesses. This article explores the experiences of four GCs working at different startup companies and aims to provide resources for GCs interested in learning more about these types of roles. The article describes startup culture, including a relatively flat organizational structure, quick product iterations, and flexibility, among other unique cultural characteristics. Financial considerations are described, including how to understand and evaluate a company's financial status, along with a brief explanation of alternate forms of compensation including stock options and equity. Specifically, the article details the uncertainties and rewards of working in a fast-paced startup environment that affords opportunities to try new roles and use the genetic counseling skill set in new ways. This article aims to aid GCs in determining whether a startup environment would be a good fit, learning how to evaluate a specific startup, and understanding how to market themselves for positions at startups.

  17. Start-up Costs, Taxes and Innovative Entrepreneurship

    NARCIS (Netherlands)

    P. Darnihamedani (Pourya); J.H. Block (Jörn); S.J.A. Hessels (Jolanda); A. Simonyan (Aram)

    2015-01-01

    markdownabstract__Abstract__ Prior research suggests that start-up costs and taxes negatively influence entry into entrepreneurship. Yet, no distinction is made regarding the type of entrepreneurship, particularly innovative versus non-innovative entrepreneurship. Start-up costs, being one-off

  18. Project start-up in the architectual design processes

    NARCIS (Netherlands)

    Schaap, A; van der Voordt, Theo; Heintz, John Linke

    2010-01-01

    The goal of this paper is to discuss if knowledge from Project Start-Up theory can be of benefit in the initiation of architectural design projects, and if so, which and what form it should take. Previous research showed that Project Start-Up is a method that can improve the result of a project

  19. 30 CFR 57.14201 - Conveyor start-up warnings.

    Science.gov (United States)

    2010-07-01

    ... entire length of the conveyor is not visible from the starting switch, a system which provides visible or... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Conveyor start-up warnings. 57.14201 Section 57... Equipment Safety Practices and Operational Procedures § 57.14201 Conveyor start-up warnings. (a) When the...

  20. 30 CFR 56.14201 - Conveyor start-up warnings.

    Science.gov (United States)

    2010-07-01

    ... entire length of the conveyor is not visible from the starting switch, a system which provides visible or... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Conveyor start-up warnings. 56.14201 Section 56... Equipment Safety Practices and Operational Procedures § 56.14201 Conveyor start-up warnings. (a) When the...

  1. How Does Personal Bankruptcy Law Affect Start-ups?

    NARCIS (Netherlands)

    Cerqueiro, G.M.; Penas, M.F.

    2011-01-01

    We analyze the effect of changes in U.S. state personal exemptions on the financing structure and performance of a representative sample of start-ups. An increase in the amount of borrower’s personal wealth protected in bankruptcy reduces the availability of bank credit to all start-ups. Owners of

  2. Strategies, Uncertainty and Performance of Small Business Startups

    NARCIS (Netherlands)

    A.M. van Gelderen (Marco); M. Frese (Michael); A.R. Thurik (Roy)

    2000-01-01

    textabstractPersonal strategies of owners/founders of small business startups are related to performance and to environmental uncertainty. This is done using a longitudinal data set of some 50 Dutch startups. The results suggest a dynamic process between strategy and performance. A discrimination is

  3. New Solutions to the Funding Dilemma of Technology Startups

    Directory of Open Access Journals (Sweden)

    Ali Kousari

    2011-05-01

    Full Text Available This article explores the current funding challenges facing technology startups and describes new models based on smaller investments and collective action. First, the advantages and disadvantages of traditional startup funding models are presented, with an emphasis on venture capital and angel investment. Next, an overview of existing seed funds, or seed accelerators, shows how entrepreneurs can leverage this approach to access subsequent rounds of funding and create successful ventures. Then, an overview of crowd funding is provided, including examples of companies that have adopted this approach to funding startups and their founders. Finally, the article presents the basis of a new approach that uses crowd funding as means of attracting investors to collectives. In these business ecosystems, startups are exposed to less risk and investors can benefit from attractive returns by investing in these promising startups.

  4. Startup analysis for a high temperature gas loaded heat pipe

    Science.gov (United States)

    Sockol, P. M.

    1973-01-01

    A model for the rapid startup of a high-temperature gas-loaded heat pipe is presented. A two-dimensional diffusion analysis is used to determine the rate of energy transport by the vapor between the hot and cold zones of the pipe. The vapor transport rate is then incorporated in a simple thermal model of the startup of a radiation-cooled heat pipe. Numerical results for an argon-lithium system show that radial diffusion to the cold wall can produce large vapor flow rates during a rapid startup. The results also show that startup is not initiated until the vapor pressure p sub v in the hot zone reaches a precise value proportional to the initial gas pressure p sub i. Through proper choice of p sub i, startup can be delayed until p sub v is large enough to support a heat-transfer rate sufficient to overcome a thermal load on the heat pipe.

  5. Impact of startup scheme on Francis runner life expectancy

    Energy Technology Data Exchange (ETDEWEB)

    Gagnon, M; Tahan, S A; Bocher, P [Department of Mechanical Engineering, Ecole de technologie superieure (ETS) 1100, rue Notre-Dame Ouest, Montreal (Canada); Thibault, D, E-mail: martin.gagnon.8@ens.etsmtl.c [Institut de recherche d' Hydro-Quebec (IREQ), 1800, boul. Lionel-Boulet, Varennes, J3X 1S1 (Canada)

    2010-08-15

    Francis runners are subject to complex dynamic forces which might lead to eventual blade cracking and the need for corrective measure. Damage due to cracks in runner blades are usually not a safety issues but might generate unexpected down time and high repair cost. Avoiding the main damaging operating conditions is often the only option left to plant operators to maximize the life expectancy of their runner. The startup scheme is one of the available parameter which is controlled by the end user and could be used to minimize the damage induced to the runner. In this study, two startup schemes have been used to investigate life expectancy of Francis runner using in situ measurements. The results obtained show that the induced damage during the startup event could be significantly reduced with change to the startup scheme. In our opinion, an optimization of the startup scheme with regard to fatigue damage could extend significantly the life expectancy and the reliability of Francis runner.

  6. Various startup system designs of HPLWR and their thermal analysis

    Energy Technology Data Exchange (ETDEWEB)

    Tang, Qi [School of Physics and Engineering, Sun Yat-sen University, Guangzhou (China); Cai, Jiejin, E-mail: chiven77@hotmail.com [School of Physics and Engineering, Sun Yat-sen University, Guangzhou (China); Sino-French Institute of Nuclear Engineering and Technology, Sun Yat-sen University, Guangzhou (China)

    2013-12-15

    Highlights: • An axial one-dimensional (1D) single channel model is developed for the HPLWR core. • Various startup systems for HPLWR have been investigated and found feasible. • Characteristics of the component required for HPLWR startup designs are studied. -- Abstract: This paper summarizes the results of various startup system designs and their thermal analysis of the high performance light water reactor (HPLWR) which is the European version of the various supercritical water cooled reactor proposals. In order to study the thermal-hydraulic characteristics of the HPLWR core, a simplified axial one-dimensional (1D) single channel model is developed, which consists of fuel, cladding, coolant and moderator. The model is verified by the related results of Seppälä (2008). Both constant pressure startup systems and sliding pressure startup systems of HPLWR are presented. In constant pressure startup system, the reactor starts at supercritical pressure. It appears that compared with other SCWR designs, the weight of the component required for constant pressure startup of HPLWR is medium and reasonable. Constant pressure startup systems are found feasible from thermal analysis. And for sliding pressure startup, the reactor starts at subcritical pressure. The adequate core power of 25% with 28% flow rate and a feedwater temperature of 280 °C are determined during pressurization phase. The thermal analysis results show that the sliding pressure startup systems for HPLWR are also feasible. Considering the same flow rate as the supercritical-pressure light water-cooled fast reactor (SCFR), the component weight required is reduced in HPLWR.

  7. Start-up Strategy for Continuous Bioreactors

    Directory of Open Access Journals (Sweden)

    A.C. da Costa

    1997-06-01

    Full Text Available Abstract - The start-up of continuous bioreactors is solved as an optimal control problem. The choice of the dilution rate as the control variable reduces the dimension of the system by making the use of the global balance equation unnecessary for the solution of the optimization problem. Therefore, for systems described by four or less mass balance equations, it is always possible to obtain an analytical expression for the singular arc as a function of only the state variables. The steady state conditions are shown to satisfy the singular arc expression and, based on this knowledge, a feeding strategy is proposed which leads the reactor from an initial state to the steady state of maximum productivity

  8. Innovative Startup-Projects: Experience, Evaluation, Implementation Contradictions

    Directory of Open Access Journals (Sweden)

    Inshakov Maksim Olegovich

    2015-09-01

    Full Text Available Innovative companies in the conditions of global post-crisis economic recovery and increased economic activity become again a promising area for investments of large investment and venture capital funds, venture divisions of large transnational corporations, business angels and other private investors. This is confirmed by the data on the increase in the volume of venture capital market in the US and Europe and on a significant increase in the cost of the leading foreign and Russian start-up companies which are rated as of 2014 in the present article. The comparative analysis of the leading Russian and foreign start-ups showed the prevalence of companies engaged in the field of IT-Internet-Mobile and focused on the provision of various kinds of innovative services to consumers among the foreign participants of the rating. Among Russian startups-winners the companies of technological orientation (biological, medical, and “clean” technologies dominate. They reflect the increasing importance of start-ups in the innovative development of the Russian economy. Participation in such competitions and ratings is a favorable factor of promoting start-ups, increasing awareness of potential investors and consumers of start-up products. The importance of start-ups formation and the development of effective regional and national innovation systems update the studies related to the identification of the fundamental contradictions in the activities of Russian start-ups and to the development of recommendations for their resolution. The article identifies the key issues of economic, organizational, informational and marketing character causing the collapse of start-up projects in the Russian economy in modern conditions.

  9. Product innovation and commercialization in lean global start-ups

    DEFF Research Database (Denmark)

    Tanev, Stoyan; Rasmussen, Erik Stavnsager; Zijdemans, Erik

    2015-01-01

    The paper examines the distinctive characteristics of product innovation and commercialization in Lean Global Start-up (LGS) – new technology firms which have adopted a lean and global path from or near to their inception. It suggests an uncertainty vs risk framework which allows integrating two...... research streams – Born Global (BG) firms and lean start-ups. In addition to its integrative theoretical value, the paper offers insights for lean start-up managers dealing with the challenges of a global start....

  10. "Size Matters": Women in High Tech Start-Ups

    Science.gov (United States)

    Lackritz, Hilary

    2001-03-01

    For those who want constant excitement, change, and rapid opportunities to have an impact in the technical world, start-up companies offer wonderful challenges. This talk will focus realistically on rewards and risks in the start-up world. An outline of the differences between the high tech start-ups and the academic and consulting worlds from a personal viewpoint will be presented. Size usually does matter, and in this case, small size can equal independence, entrepreneurship, and other advantages that are hard to come by in Dilbert’s corporate world.

  11. Knowledge Sharing Dan Inovasi Pada Industri Startup (Studi pada 15 Perusahaan Startup di Program Indigo Incubator, Bandung Digital Valley

    Directory of Open Access Journals (Sweden)

    Dodi Jayen Suwarno

    2017-04-01

    ABSTRACT Year 2014 become the beginning of massive investments of foreign investors to several startups in Indonesia. It triggers the creation of making startup incubation program by considering the use of knowledge sharing activity, which has been previously known as a success factor of former startups in the world. Knowledge sharing itself can increase innovation. Indigo Incubator program made by Telkom Group is of the example located in Bandung Digital Valley. With the expectation of innovation enhancement after incubation, we still know there are some startups that failed and dipersed at the end. This study aims to determine whether there is influence of knowledge sharing on innovation, and the statistical amount of the contributions. The object of research are determined based on the 15 startups incubated at Indigo Incubator program batch 2015. The method used by distributing a questionnaire, which is then processed using linear regression technique. Based on the analysis that there is significant influence of knowledge sharing on innovation. Tthe result illustrates that knowledge sharing need to be considered for various parties in the future to create high competitive startup with advanced innovation. This research is also beneficial for scientific literature development, especially Human Resources, as well can become the reference materials for business related to knowledge sharing practice and its linking to Innovation. Keywords: knowledge sharing, innovation, startup, incubation.

  12. Decision Enhancement Services for Small and Medium Enterprise Start-Ups in Uganda

    NARCIS (Netherlands)

    Sol, H G; Basaza, Habinka; Sprague, Ralph H.

    2012-01-01

    While start-up firms create a substantial economic impact on most economies, the failure rate of start-up firms seems to remain high due to inadequate agile decision services. Deciding to start-up mining Small and Medium Enterprises (SME) is a challenging task in Uganda. Research on SME start-up

  13. Sources of persistence in regional start-up rates-evidence from Sweden

    NARCIS (Netherlands)

    Andersson, Martin; Koster, Sierdjan

    This article assesses the spatial-temporal persistence of a dynamic phenomenon: start-ups. Two mechanisms that explain persistence in start-up rates are distinguished: (i) determinants of start-ups that are spatially 'sticky' and durable and (ii) path dependence in start-up activities in the form of

  14. 77 FR 71323 - Reconsideration of Certain New Source and Startup/Shutdown Issues: National Emission Standards...

    Science.gov (United States)

    2012-11-30

    ... AGENCY 40 CFR Parts 60 and 63 RIN 2060-AR62 Reconsideration of Certain New Source and Startup/Shutdown..., the requirements applicable during periods of startup and shutdown for MATS, the startup and shutdown... C. Startup and Shutdown Provisions V. Discussion of Provisions Subject to Reconsideration--Utility...

  15. Řízení rozvoje start-up společnosti

    OpenAIRE

    Paluch, Juraj

    2013-01-01

    Thesis deals with startup companies and their development methodology. The main aim is to present a model of startup company development. Within the theoretical part successful and unsuccessful businesses are analyzed and selected approaches to the development of startup companies are explained. In practical part, based on the findings a model for startup company development is proposed.

  16. Are start-ups the same everywhere? The urban-rural skill gap in Swedish entrepreneurship

    NARCIS (Netherlands)

    Andersson, Martin; Koster, Sierdjan; Lavesson, Niclas

    2016-01-01

    There is a vast literature documenting the geography of start-ups and their impact on regional economic development. A shortcoming of many studies is their focus on the frequency of start-ups rather than the characteristics of start-ups. Understanding the heterogeneity in start-ups is important as

  17. CERN confident of LHC start-up in 2007

    CERN Multimedia

    2007-01-01

    "Delegates attending the 140th meeting of CERN Council heard a confident report from the Laboratory about the scheduled start-up of the world's highest energy particle accelerator, the Large Hadron Collier (LHC), in 2007." (1 page)

  18. Intellectual property and financing strategies for technology startups

    CERN Document Server

    Halt, Jr , Gerald B; Stiles, Amber R; Fesnak, Robert

    2017-01-01

    This book offers a comprehensive, easy to understand guide for startup entities and developing companies, providing insight on the various sources of funding that are available, how these funding sources are useful at each stage of a company’s development, and offers a comprehensive intellectual property strategy that parallels each stage of development. The IP strategies offered in this book take into consideration the goals that most startups and companies have at each stage of development, as well as the limitations that exist at each stage (i.e., limited available resources earmarked for intellectual property asset development), and provides solutions that startups and companies can implement to maximize their return on intellectual property investments. This book also includes a number of descriptive examples, case studies and scenarios to illustrate the topics discussed, and is intended for use by startups and companies across all industries. Readers will garner an appreciation for the value that inte...

  19. Startup, Shutdown, & Malfunction (SSM) Emissions at Industrial Facilities

    Science.gov (United States)

    EPA issued a final action to ensure states have plans in place that are fully consistent with the Clean Air Act and recent court decisions concerning startup, shutdown and malfunction (SSM) operations.

  20. Accelerating Research Innovation by Adopting the Lean Startup Paradigm

    National Research Council Canada - National Science Library

    Kaisa Still

    2017-01-01

    .... In this article, we explore how the lean startup paradigm, which validates the market for a product with a business model that can sustain subsequent scaling, has led to a new process model to accelerate innovation...

  1. The Rationality and Irrationality of Financing Green Start-Ups

    National Research Council Canada - National Science Library

    Linda Bergset

    2015-01-01

    ... market. Due to specific product/service characteristics, entrepreneurial motivation and company strategies that might differ from that of other start-ups, these companies might struggle even more than...

  2. University Knowledge Spillovers & Regional Start-up Rates

    DEFF Research Database (Denmark)

    Hellerstedt, Karin; Wennberg, Karl; Frederiksen, Lars

    2014-01-01

    This chapter investigates how regional start-up rates in the knowledge-intensive services and high-tech industries are influenced by knowledge spillovers from both universities and firm-based R&D activities. Integrating insights from economic geography and organizational ecology into the literature...... on entrepreneurship, we develop a theoretical framework which captures how both supply- and demand-side factors mold the regional bedrock for start-ups in knowledge-intensive industries. Using multilevel data of all knowledge-intensive start-ups across 286 Swedish municipalities between 1994 and 2002 we demonstrate...... how characteristics of the economic and political milieu within each region influence the ratio of firm births. We find that knowledge spillovers from universities and firm-based R&D strongly affect the start-up rates for both high-tech firms and knowledge-intensive services firms. Further, the start...

  3. Impact of entrepreneurship policies on opportunity to startup

    Directory of Open Access Journals (Sweden)

    Ali Davari

    2017-09-01

    Full Text Available During the previous decades, policy makers have formulated policies for developing entrepreneurship in different countries in order to decrease unemployment and poverty toward sustainable development. Some of these policies include encouraging people to be an entrepreneur, opportunity creation, educating new skills to entrepreneurs and so on. In recent years an appropriate context has been formed for entrepreneurship development in Iran and some programs have been executed. Therefore, formulating appropriate frameworks to guide Iranian government in this way is a necessity. This paper evaluates the impact of entrepreneurship policies on opportunity to startup in Iran. The results of path analysis indicate that supportive financial and non-financial actions influence positively on opportunity to startup. In addition, education and culture also influence positively on opportunity to startup. Finally, legislation also positively influences on opportunity to startup.

  4. Device for start-up of gas-lift wells

    Energy Technology Data Exchange (ETDEWEB)

    Poladov, A.R.; Melkumov, R.M.; Ramazanova, R.A.; Trostnikov, B.N.

    1982-01-01

    A device is proposed for start-up of gas lift wells containing a coupling with radial channels in which valves are arranged installed with the possibility of interaction with the sliding bushing. In order to decrease the time for start-up of the gas-lift wells, the coupling valves are spherical, while the sliding bushing has a reduced through section in the upper part. In the sliding bushing, the radial channels are made at an acute angle to its axis.

  5. The Rationality and Irrationality of Financing Green Start-Ups

    OpenAIRE

    Bergset, Linda

    2015-01-01

    Green start-ups contribute towards a transition to a more sustainable economy by developing sustainable and environmentally friendly innovation and bringing it to the market. Due to specific product/service characteristics, entrepreneurial motivation and company strategies that might differ from that of other start-ups, these companies might struggle even more than usual with access to finance in the early stages. This conceptual paper seeks to explain these challenges through the theoretical...

  6. The role of relationships in start-up development

    DEFF Research Database (Denmark)

    Mattsson, Jan; Helmersson, Helge; Standing, Craig

    2017-01-01

    Relationships are important in the business start-up phase for a variety of reasons. Internal relationships can support knowledge exchange that determines the business model development and external relationships can facilitate a wide range of opportunities, support and insights. The paper explains...... important relationships were formed during the initial start-up period targeting international expansion. Interaction with early adopters enabled a rapid evolution of the business platform with the aim to build a community of users to support development....

  7. Startup and mode competition in a 420 GHz gyrotron

    Science.gov (United States)

    Qixiang Zhao, A.; Sheng Yu, B.; Tianzhong Zhang, C.

    2017-09-01

    In the experiments of a 420 GHz second-harmonic gyrotron, it is found that the electron beam voltage and current ranges for single mode operation of TE17.4 are slightly narrower than those in the simulation. To explain this phenomenon, the startup scenario has been investigated with special emphasis on mode competition. The calculations indicate that the decreases of the operating ranges are caused by the voltage overshoot in the startup scenario.

  8. University Start-ups: A Better Business Model

    Science.gov (United States)

    Dehn, J.; Webley, P. W.

    2015-12-01

    Many universities look to start-up companies as a way to attract faculty, supporting research and students as traditional federal sources become harder to come by. University affiliated start-up companies can apply for a broader suite of grants, as well as market their services to a broad customer base. Often university administrators see this as a potential panacea, but national statistics show this is not the case. Rarely do universities profit significantly from their start-ups. With a success rates of around 20%, most start-ups end up costing the university money as well as faculty-time. For the faculty, assuming they want to continue in academia, a start-up is often unattractive because it commonly leads out of academia. Running a successful business as well as maintaining a strong teaching and research load is almost impossible to do at the same time. Most business models and business professionals work outside of academia, and the models taught in business schools do not merge well in a university environment. To mitigate this a new business model is proposed where university start-ups are aligned with the academic and research missions of the university. A university start-up must work within the university, directly support research and students, and the work done maintaining the business be recognized as part of the faculty member's university obligations. This requires a complex conflict of interest management plan and for the companies to be non-profit in order to not jeopardize the university's status. This approach may not work well for all universities, but would be ideal for many to conserve resources and ensure a harmonious relationship with their start-ups and faculty.

  9. Evidence of Bootstrap Financing among Small Start-Up Firms

    OpenAIRE

    Howard E. Van Auken; Lynn Neeley

    1996-01-01

    This study examines the use of bootstrap financing for a sample of 78 firms in a Midwestern state. The results show that traditional sources of capital accounted for 65% of the firms' start-up capital and 35% of the start-up capital was obtained from bootstrap sources. A Chi-squared analysis indicates a significant difference between the percentage of (!) sole proprietorship versus other firms and (2) construction/manufacturing versus other types of firms using bootstrap financing as compared...

  10. Aeroelastic Modeling of a Nozzle Startup Transient

    Science.gov (United States)

    Wang, Ten-See; Zhao, Xiang; Zhang, Sijun; Chen, Yen-Sen

    2014-01-01

    Lateral nozzle forces are known to cause severe structural damage to any new rocket engine in development during test. While three-dimensional, transient, turbulent, chemically reacting computational fluid dynamics methodology has been demonstrated to capture major side load physics with rigid nozzles, hot-fire tests often show nozzle structure deformation during major side load events, leading to structural damages if structural strengthening measures were not taken. The modeling picture is incomplete without the capability to address the two-way responses between the structure and fluid. The objective of this study is to develop a tightly coupled aeroelastic modeling algorithm by implementing the necessary structural dynamics component into an anchored computational fluid dynamics methodology. The computational fluid dynamics component is based on an unstructured-grid, pressure-based computational fluid dynamics formulation, while the computational structural dynamics component is developed under the framework of modal analysis. Transient aeroelastic nozzle startup analyses at sea level were performed, and the computed transient nozzle fluid-structure interaction physics presented,

  11. Giving start-ups a helping hand

    CERN Multimedia

    2008-01-01

    The French-Swiss foundation for research and technology (FFSRT) joined forces with CERN to organise an information day on setting up new businesses, at the Globe of Science and Innovation. The participants heard talks by entrepreneurs who started out at CERN, sharing their experiences and difficulties.CERN is a hot-bed of high-tech skills and know-how, and the Organization works actively to transfer this expertise to society. Some such innovations can lead to new business start-ups, but it can be extremely difficult to obtain the information and support you need to find your way through the inevitable administrative labyrinth. By opening its doors to the Fondation franco-suisse pour la recherche et la technologie (FFSRT) and hosting this "Entrepreneurial Day" on 7 March, CERN has clearly flagged its desire to assist budding entrepreneurs. The day was jointly kicked off by Olga Hooft, General Manager of the FFSRT, and Maximilian Metzger, CERN’s Se...

  12. Reactivity Measurement and Analysis System (RMAS-7)

    Energy Technology Data Exchange (ETDEWEB)

    Cordero, D.; Izquierdo, J.

    2015-07-01

    This paper tries to describe the Reactivity Measurement and Analysis System 7 (RMAS-7), which is an Areva’s hardware and software solution capable of accomplishing the physic startup tests in a work shift. RMAS-7 is a modular solution designed to be a powerful, convenient data collection and analysis system based on Ethernet communication network. This last feature allows RMAS-7 to have a distributed architecture. (Author)

  13. Start-up and safety systems of a high performance light water reactor

    Energy Technology Data Exchange (ETDEWEB)

    Schlagenhaufer, Marc; Straflinger, Joerg; Schulenberg, Thomas [Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen (Germany). Inst. for Nuclear and Energy Technologies; Bittermann, Dietmar [AREVA NP GmbH, Erlangen (Germany). NEP-G Process

    2010-05-15

    The HPLWR steam cycle is analysed with the commercial system code APROS. A combined shut-down and start-up plant control system is designed, which is operated below 50% load under constant pressure and tripped turbine. An additional controlling system is implemented, which enables the constant pressure operation and allows preheating of the feedwater as long as possible to avoid severe material temperature changes in thick-walled components. The same shut-down system is used in the opposite direction to start-up the plant at constant pressure. In a future detailed design, the reactivity feedback should be included to allow a realistic tuning of the control parameters. The safety systems of the HPLWR, which allow maintaining the core coolant flow rate, were presented. The ADS, LPCI and HPCI are implemented in the HPLWR steam cycle, which is modelled in APROS, and are currently investigated in respect to needed coolant injection rates at low and high pressure, ADS flow cross sections, ADS actuation pressures and safety response times. (orig.)

  14. Effect of bioaugmentation and biostimulation on sulfate-reducing column startup captured by functional gene profiling.

    Science.gov (United States)

    Pereyra, Luciana P; Hiibel, Sage R; Perrault, Elizabeth M; Reardon, Kenneth F; Pruden, Amy

    2012-10-01

    Sulfate-reducing permeable reactive zones (SR-PRZs) depend upon a complex microbial community to utilize a lignocellulosic substrate and produce sulfides, which remediate mine drainage by binding heavy metals. To gain insight into the impact of the microbial community composition on the startup time and pseudo-steady-state performance, functional genes corresponding to cellulose-degrading (CD), fermentative, sulfate-reducing, and methanogenic microorganisms were characterized in columns simulating SR-PRZs using quantitative polymerase chain reaction (qPCR) and denaturing gradient gel electrophoresis (DGGE). Duplicate columns were bioaugmented with sulfate-reducing or CD bacteria or biostimulated with ethanol or carboxymethyl cellulose and compared with baseline dairy manure inoculum and uninoculated controls. Sulfate removal began after ~ 15 days for all columns and pseudo-steady state was achieved by Day 30. Despite similar performance, DGGE profiles of 16S rRNA gene and functional genes at pseudo-steady state were distinct among the column treatments, suggesting the potential to control ultimate microbial community composition via bioaugmentation and biostimulation. qPCR revealed enrichment of functional genes in all columns between the initial and pseudo-steady-state time points. This is the first functional gene-based study of CD, fermentative and sulfate-reducing bacteria and methanogenic archaea in a lignocellulose-based environment and provides new qualitative and quantitative insight into startup of a complex microbial system. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  15. Sources of Persistence in Regional Start-Up Rates - evidence from Sweden

    OpenAIRE

    Andersson, Martin; Koster, Sierdjan

    2009-01-01

    The relationship between start-up rates and regional economic development has been studied rather extensively in recent years. Dynamics in start-up rates have however received considerably less attention. In this paper we analyze the persistence of start-up rates across Swedish regions over a decade and analyze the sources of persistence. We find overall persistence in start-up rates. Start-up rates of a decade earlier are able to explain over 40 % of the variation in current start-up rates a...

  16. Lean Start-up in Established Companies: Potentials and Challenges

    DEFF Research Database (Denmark)

    Goduscheit, René Chester

    2018-01-01

    Lean start-up is an emergent perspective on how entrepreneurs can bring new products and services to the market. This approach challenges the dominant role of lengthy business plans, linear product development processes, and seeking complete overview of the potential of the new products/services ......Lean start-up is an emergent perspective on how entrepreneurs can bring new products and services to the market. This approach challenges the dominant role of lengthy business plans, linear product development processes, and seeking complete overview of the potential of the new products....../services before market launch. Instead it suggests that start-ups could benefit from a ‘minimum-viable product’ approach where products and services are launched when they contain critical features. The emphasis in the lean start-up approach is on business models rather than the elaborate business plan...... at the companies (strategy meetings, development workshops etc.). The aim is to shed light on the implications for companies that seek to employ lean start-up. These implications will be aimed at aspects like innovation management, organizational structure, customer relations etc....

  17. The Rationality and Irrationality of Financing Green Start-Ups

    Directory of Open Access Journals (Sweden)

    Linda Bergset

    2015-11-01

    Full Text Available Green start-ups contribute towards a transition to a more sustainable economy by developing sustainable and environmentally friendly innovation and bringing it to the market. Due to specific product/service characteristics, entrepreneurial motivation and company strategies that might differ from that of other start-ups, these companies might struggle even more than usual with access to finance in the early stages. This conceptual paper seeks to explain these challenges through the theoretical lenses of entrepreneurial finance and behavioural finance. While entrepreneurial finance theory contributes to a partial understanding of green start-up finance, behavioural finance is able to solve a remaining explanatory deficit produced by entrepreneurial finance theory. Although some behavioural finance theorists are suggesting that the current understanding of economic rationality underlying behavioural finance research is inadequate, most scholars have not yet challenged these assumptions, which constrict a comprehensive and realistic description of the reality of entrepreneurial finance in green start-ups. The aim of the paper is thus, first, to explore the specifics of entrepreneurial finance in green start-ups and, second, to demonstrate the need for a more up-to-date conception of rationality in behavioural finance theory in order to enable realistic empirical research in this field.

  18. Start-up Funding via Equity Crowdfunding in Germany

    DEFF Research Database (Denmark)

    Angerer, Martin; Brem, Alexander; Kraus, Sascha

    2017-01-01

    Entrepreneurs often struggle to find sufficient funding for their start-ups. A relatively new way for companies to attract capital is via an internet platform, locating investors who in return receive something in return for their ventures. Equity crowdfunding is one of several types of crowdfund......Entrepreneurs often struggle to find sufficient funding for their start-ups. A relatively new way for companies to attract capital is via an internet platform, locating investors who in return receive something in return for their ventures. Equity crowdfunding is one of several types...... of crowdfunding, and is also known as crowdinvesting in the German-speaking realm. This article predominantly advances the scientific knowledge regarding the success factors of equity crowdfunding for German start-ups. The study conducted nine qualitative interviews with start-ups and crowdinvesting platforms....... Its first result is that German start-ups select crowdinvesting because (1) it is a funding opportunity and (2) it has an expected marketing effect. To organize the results of relevant success factors, the Crowdinvesting Success Model was designed by the researchers. This supports German entrepreneurs...

  19. Coordination chemistry and applications of versatile 4,5-diazafluorene derivatives.

    Science.gov (United States)

    Annibale, Vincent T; Song, Datong

    2016-01-07

    This perspective review will examine the coordination chemistry and applications of metal complexes of 4,5-diazafluorene derivatives. The versatile derivatives of 4,5-diazafluorene can serve multiple roles, and display a number of coordination modes. The ambidentate derivatives with multiple coordination sites can allow for the syntheses of coordination polymers, multimetallic, and macrocyclic complexes. In addition, certain 4,5-diazafluorene derivatives can serve as spectator ligands to support reactivity at the metal centre, or as reactive actor ligands engaging in atypical reactivity patterns. The applications of metal complexes of 4,5-diazafluorene derivatives in catalysis, photochemistry and photophysics, as well as in bioinorganic chemistry are also surveyed.

  20. Glycodendrimers: versatile tools for nanotechnology

    Directory of Open Access Journals (Sweden)

    René Roy

    2013-01-01

    Full Text Available Combining nanotechnology with glycobiology has triggered an exponential growth of research activities in the design of novel functional bionanomaterials (glyconanotechnology. More specifically, recent synthetic advances towards the tailored and versatile design of glycosylated nanoparticles namely glyconanoparticles, considered as synthetic mimetics of natural glycoconjugates, paved the way toward diverse biomedical applications. The accessibility of a wide variety of these structured nanosystems, in terms of shapes, sizes, and organized around stable nanoparticles have readily contributed to their development and applications in nanomedicine. In this context, glycosylated gold-nanoparticles (GNPs, glycosylated quantum dots (QDs, fullerenes, single-wall natotubes (SWNTs, and self-assembled glycononanoparticles using amphiphilic glycopolymers or glycodendrimers have received considerable attention to afford powerful imaging, therapeutic, and biodiagnostic devices. This review will provide an overview of the most recent syntheses and applications of glycodendrimers in glycoscience that have permitted to deepen our understanding of multivalent carbohydrate-protein interactions. Together with synthetic breast cancer vaccines, inhibitors of bacterial adhesions to host tissues including sensitive detection devices, these novel bionanomaterials are finding extensive relevance.

  1. Imidazole: Having Versatile Biological Activities

    Directory of Open Access Journals (Sweden)

    Amita Verma

    2013-01-01

    Full Text Available Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it improves pharmacokinetic characteristics of lead molecules and thus is used as a remedy to optimize solubility and bioavailability parameters of proposed poorly soluble lead molecules. There are several methods used for the synthesis of imidazole-containing compounds, and also their various structure reactions offer enormous scope in the field of medicinal chemistry. The imidazole derivatives possess extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to review the biological activities of imidazole during the past years.

  2. Versatile Chemical Derivatizations to Design Glycol Chitosan-Based Drug Carriers

    Directory of Open Access Journals (Sweden)

    Sung Eun Kim

    2017-10-01

    Full Text Available Glycol chitosan (GC and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules, and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.

  3. Quel contrôle de gestion pour les startups ?

    OpenAIRE

    Meyssonnier, François

    2015-01-01

    Une étude de huit PME fondées sur la science permet d’identifier les spécificités du contrôle de gestion des startups. Dans les startups émergentes le dirigeant n’utilise que des linéaments de contrôle de gestion essentiellement pour développer son approche cognitive du business model. Dans les startups en croissance le contrôle de gestion a un rôle de garde-fou et les outils de pilotage de la performance sont utilisés essentiellement de façon interactive et pour la prévision. Les principaux ...

  4. Start-up processes’ efficiency of turbine jet engines

    Directory of Open Access Journals (Sweden)

    Jankowski Antoni

    2016-12-01

    Full Text Available The paper presents diagnoses of example start-up processes of drive units built in military aircraft operated in the Dęblin's “School of Eaglets” during the flight. The significance of this process is very important, especially from the point of view of flight safety, especially as it concerns the training aircraft, on which officer cadets-candidates for pilots are trained. The diagnosis of the start-up process was conducted using data from on-board flight recorders recorded during a flight training, whose aim was an emergency launch of particular drive units, and with the help of the so-called phase mapping of the selected operating parameters of the particular flight drive systems. The standard diagram of typical start-up systems was shown, while presenting their base subassemblies. At the end, the obtained results and the main problems that need intervention were commented, as well as further preventive activities were proposed.

  5. A Sales Execution Strategy Guide for Technology Startups

    Directory of Open Access Journals (Sweden)

    Ian Gilbert

    2011-10-01

    Full Text Available The majority of startups fail to consider sales execution as part of their overall strategy. This article demonstrates how a sales execution strategy can help a company take a product or service to market more efficiently and effectively by focusing on the customers that are key to generating revenue. Combined with techniques for recruiting effectively and measuring sales outcomes, a sales execution strategy helps technology startups exceed growth aspirations and potentially reduce or even eliminate the requirement for external investment. In this article, we first describe the focus of assistance currently given to startups and the reasons why sales execution strategies are often overlooked. Next, we outline recommendations for developing, implementing, and supporting a sales execution strategy. Finally, we summarize the key points presented in the article.

  6. A Data Scientist's Guide to Start-Ups.

    Science.gov (United States)

    Provost, Foster; Webb, Geoffrey I; Bekkerman, Ron; Etzioni, Oren; Fayyad, Usama; Perlich, Claudia

    2014-09-01

    In August 2013, we held a panel discussion at the KDD 2013 conference in Chicago on the subject of data science, data scientists, and start-ups. KDD is the premier conference on data science research and practice. The panel discussed the pros and cons for top-notch data scientists of the hot data science start-up scene. In this article, we first present background on our panelists. Our four panelists have unquestionable pedigrees in data science and substantial experience with start-ups from multiple perspectives (founders, employees, chief scientists, venture capitalists). For the casual reader, we next present a brief summary of the experts' opinions on eight of the issues the panel discussed. The rest of the article presents a lightly edited transcription of the entire panel discussion.

  7. Porovnanie slovenského a českého start-up ekosystému

    OpenAIRE

    Pipasová, Jaroslava

    2017-01-01

    This master thesis deals with the comparison of startup ecosystems in the Czech Republic and Slovakia. The goal is to discover which of these two countries has more developed startup ecosystem. The first chapter aims to define startup and illustrates its importance and development in both countries. The second chapter analyzes the characteristic of startup ecosystem, startup financing and supporting institutions in the 2 countries. The final chapter contains a comparison of the startup ecosys...

  8. Start-up business plan: organic food restaurant in Bilbao

    OpenAIRE

    Sharafutdinova, Alisa

    2016-01-01

    My thesis is a start-up business plan for a restaurant in Bilbao, Spain. This product-oriented thesis is a part of the Hospitality Management program of Haaga-Helia UAS. The purpose of this work is to build a theoretical framework about successful business plan writing and follow it up by writing a start-up business plan according to the studied theory. A business plan is a first important step for starting a business and the practice of writing it will be beneficial while helping me to ...

  9. Methanol: A Versatile Fuel for Immediate Use

    Science.gov (United States)

    Reed, T. B.; Lerner, R. M.

    1973-01-01

    Advocates the large-scale production and use of methanol as a substitute for the diminishing reserves of low-cost petroleum resources. Describes the manufacturing process and advantages of the versatile fuel. (JR)

  10. Aloittelevan start-up yrittäjän opas rahoitukseen

    OpenAIRE

    Lamminsalo, Matti

    2015-01-01

    Opinnäytetyö käsittelee start-up rahoitusta ja siihen liittyviä toimintamalleja. Opinnäytetyön tuloksena on syntynyt opaskirja: Aloittelevan start-up yrittäjän opas rahoitukseen. Research about start-up ecosystem with investment aspect. As a result guidebook for start-up investment and how to raise a fund was writen.

  11. 40 CFR 65.6 - Startup, shutdown, and malfunction plan and procedures.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Startup, shutdown, and malfunction... (CONTINUED) AIR PROGRAMS (CONTINUED) CONSOLIDATED FEDERAL AIR RULE General Provisions § 65.6 Startup... Group 2A or Group 2B process vents. (b) Startup, shutdown, and malfunction plan—(1) Description and...

  12. 40 CFR 63.2852 - What is a startup, shutdown, and malfunction plan?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What is a startup, shutdown, and... Production Compliance Requirements § 63.2852 What is a startup, shutdown, and malfunction plan? You must...)(2) malfunction period, or the § 63.2850(c)(2) or (d)(2) initial startup period. The SSM plan must...

  13. 77 FR 73968 - Reconsideration of Certain New Source and Startup/Shutdown Issues: National Emission Standards...

    Science.gov (United States)

    2012-12-12

    ... AGENCY 40 CFR Parts 60 and 63 RIN 2060-AR62 Reconsideration of Certain New Source and Startup/Shutdown... ``Reconsideration of Certain New Source and Startup/Shutdown Issues: National Emission Standards for Hazardous Air... November 30, 2012, proposed ``Reconsideration of Certain New Source and Startup/Shutdown Issues: National...

  14. 40 CFR 62.14645 - What happens during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false What happens during periods of startup... Limits § 62.14645 What happens during periods of startup, shutdown, and malfunction? (a) The emission limitations and operating limits apply at all times except during periods of CISWI unit startup, shutdown, or...

  15. 40 CFR 60.2918 - What happens during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... of startup, shutdown, and malfunction? The emission limitations and operating limits apply at all times except during OSWI unit startups, shutdowns, or malfunctions. Performance Testing ...

  16. 40 CFR 60.3025 - What happens during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... during periods of startup, shutdown, and malfunction? The emission limitations and operating limits apply at all times except during OSWI unit startups, shutdowns, or malfunctions. Model Rule—Performance...

  17. 40 CFR 60.2120 - What happens during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... 1, 2001 Emission Limitations and Operating Limits § 60.2120 What happens during periods of startup... during CISWI unit startups, shutdowns, or malfunctions. (b) Each malfunction must last no longer than 3...

  18. 40 CFR 60.2685 - What happens during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 6 2010-07-01 2010-07-01 false What happens during periods of startup... happens during periods of startup, shutdown, and malfunction? (a) The emission limitations and operating limits apply at all times except during CISWI unit startups, shutdowns, or malfunctions. (b) Each...

  19. 40 CFR 60.2195 - What information must I submit prior to initial startup?

    Science.gov (United States)

    2010-07-01

    ... initial startup? 60.2195 Section 60.2195 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY..., 2001 Recordkeeping and Reporting § 60.2195 What information must I submit prior to initial startup? You... startup. (a) The type(s) of waste to be burned. (b) The maximum design waste burning capacity. (c) The...

  20. 40 CFR 60.2953 - What information must I submit prior to initial startup?

    Science.gov (United States)

    2010-07-01

    ... initial startup? 60.2953 Section 60.2953 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... initial startup? You must submit the information specified in paragraphs (a) through (e) of this section prior to initial startup. (a) The type(s) of waste to be burned. (b) The maximum design waste burning...

  1. 78 FR 38001 - Reconsideration of Certain Startup/Shutdown Issues: National Emission Standards for Hazardous Air...

    Science.gov (United States)

    2013-06-25

    ..., FRL-9827-1] RIN 2060-AR62 Reconsideration of Certain Startup/Shutdown Issues: National Emission... published in the Federal Register the proposed rule, ``Reconsideration of Certain New Source and Startup....'' That proposal opened for reconsideration certain issues, including those related to startup and...

  2. Power in a startup's relationships with its established partners : Interactions between structural and behavioural power

    NARCIS (Netherlands)

    Oukes, Tamara; von Raesfeld Meijer, Ariane; Groen, Aard

    2017-01-01

    Power plays a key role in the relationships between startups and established organisations. Yet researchers have devoted little attention to the startup's perspective on power in such relationships. To study startups' view on power, a useful starting point is their structural power, but this also

  3. The Performance Of Team Start-Ups In The First Phases Of The Life Course

    NARCIS (Netherlands)

    F.C. Stam (Erik); V. Schutjens (Veronique)

    2004-01-01

    textabstractThis article describes the benefits and pitfalls of starting a firm with an entrepreneurial team, drawing on a longitudinal empirical analysis of the life course of 90 team start-ups and 1196 solo start-ups in the Netherlands. In the first three years of their existence, team start-ups

  4. Skill Heterogeneity in Startups and its Development over Time

    DEFF Research Database (Denmark)

    Kaiser, Ulrich; Müller, Bettina

    2015-01-01

    We study how startup teams are assembled in terms of team member human capital characteristics. To this end, we derive a statistically motivated benchmark for new venture team heterogeneity in terms of observed team member characteristics to generate stylized facts about team member diversity at ...

  5. CERN confident of LHC start-up in 2007

    CERN Multimedia

    2006-01-01

    "Delegates attending the 140th meeting of CERN Council today heard a confident report from the Laboratory about the scheduled start-up of the world's highest energy particle accelerator, the Large Hadron Collider (LHC) in 2007." (1/2 page)

  6. CERN confident of LHC start-up in 2007

    CERN Multimedia

    Vanden Broeck, Renilde

    2007-01-01

    "Delegates attending the 140th meeting of CERN Council today heard a confident report from the Laboratory about the scheduled start-up of the world's highest energy particle accelerator, the Large Hadron Collier (LHC) in 2007. (1/2 page)

  7. Characteristics Contributing to High-Technology Start-Up Success

    DEFF Research Database (Denmark)

    Goslin, L.; Brown, W.; Palm, T.

    1993-01-01

    The factors contributing to the success of high technology start-up firms have received much discussion in current business literature. The discussion of the characteristics of success has been based on increasing substantiation by empirical research. The available information suggests that the p......The factors contributing to the success of high technology start-up firms have received much discussion in current business literature. The discussion of the characteristics of success has been based on increasing substantiation by empirical research. The available information suggests...... across national borders and how, if at all, national origin may influence the successful high technology firm. This paper discusses the results of a limited study, which compared the management/organizational characteristics of a small sample of firms. Some of the firms were venture capital funded high...... technology start-up firms. For each country set an information base was developed on characteristics of the high technology start-up situation. The information relates to an expanding common data base (U.S.: Goslin, Kiehi; Canadian: Doutriaux) which is being developed. Additional information was obtained...

  8. Impedance estimation of photovoltaic modules for inverter start-up ...

    Indian Academy of Sciences (India)

    Starting-up of photovoltaic (PV) inverters involves pre-charging of the input dc bus capacitance. Ideally, direct ... The start-up transient is also affected by the contactor connecting the PV modules to the inverter input dc bus. ... The analysis of this paper can be used to estimate the expected peak inrush current in PV inverters.

  9. Personality Traits and the Evaluation of Start-up Subsidies

    NARCIS (Netherlands)

    Caliendo, M.; Künn, Steffen; M., Weißenberger,

    2016-01-01

    Many countries support business start-ups to spur economic growth and reduce unemployment with different programmes. Evaluation studies of such programmes commonly rely on the conditional independence assumption (CIA), allowing a causal interpretation of the results only if all relevant variables

  10. Trends in the Crowdfunding of Educational Technology Startups

    Science.gov (United States)

    Antonenko, Pavlo D.; Lee, Brenda R.; Kleinheksel, A. J.

    2014-01-01

    This article presents an analysis of active crowdfunding campaigns posted on ten crowdfunding platforms in May 2013 to provide a glimpse of the recent trends in the crowdfunding of educational technology startups. We describe the characteristics of the most successful crowdfunding campaigns in educational technology and identify the most popular…

  11. Construction, start-up and operation of a continuously aerated ...

    African Journals Online (AJOL)

    scale SHARON reactor are discussed, along with the construction of the reactor. Special attention is given to the start-up in view of possible toxic effects of high nitrogen concentrations (up to 4 000 mgN·ℓ-1) on the nitrifier population and ...

  12. Creating Start-up Companies around NCI Inventions | Poster

    Science.gov (United States)

    By Karen Surabian, Thomas Stackhouse, and Rose Freel, Contributing Writers, and Rosemarie Truman, Guest Writer The National Cancer Institute (NCI), led by the Technology Transfer Center (TTC),  the Avon Foundation, and The Center for Advancing Innovation have partnered to create a “first-of-a-kind” Breast Cancer Start-up Challenge.

  13. Accelerating Research Innovation by Adopting the Lean Startup Paradigm

    Directory of Open Access Journals (Sweden)

    Kaisa Still

    2017-05-01

    Full Text Available Converting scientific expertise into marketable products and services is playing an increasingly important role in the launching of new ventures, the growth of existing firms, and the creation of new jobs. In this article, we explore how the lean startup paradigm, which validates the market for a product with a business model that can sustain subsequent scaling, has led to a new process model to accelerate innovation. We then apply this paradigm to the context of research at universities and other research organizations. The article is based on the assumption that the organizational context matters, and it shows how a deeper understanding of the research context could enable an acceleration of the innovation process. We complement theoretical examples with a case example from VTT Technical Research Institute of Finland. Our findings show that many of the concepts from early-acceleration phases – and the lean startup paradigm – can also be relevant in innovation discussions within the research context. However, the phase of value-proposition discovery is less adequately addressed, and that of growth discovery, with its emphasis on building on a scalable, sustainable business does not seem to be addressed with the presented innovation approaches from the research context. Hence, the entrepreneurial activities at the research context differ from those in startups and internal startups in established organizations.

  14. Start-up Funding via Equity Crowdfunding in Germany

    DEFF Research Database (Denmark)

    Angerer, Martin; Brem, Alexander; Kraus, Sascha

    2017-01-01

    Entrepreneurs often struggle to find sufficient funding for their start-ups. A relatively new way for companies to attract capital is via an internet platform, locating investors who in return receive something in return for their ventures. Equity crowdfunding is one of several types of crowdfund...

  15. Social Capital in Knowledge Intensive Start-Ups

    DEFF Research Database (Denmark)

    Neergaard, Helle; Madsen, Henning

    This paper addresses social capital in biotechnology, medico and information communication start-ups using both quantitative and qualitative data. It shows that founding teams are primarily composed of 'trusted alters' and that networking patterns are highly influenced by the entrepreneur...

  16. Acetate enhances startup of a H₂-producing microbial biocathode.

    Science.gov (United States)

    Jeremiasse, Adriaan W; Hamelers, Hubertus V M; Croese, Elsemiek; Buisman, Cees J N

    2012-03-01

    H(2) can be produced from organic matter with a microbial electrolysis cell (MEC). To decrease MEC capital costs, a cathode is needed that is made of low-cost material and produces H(2) at high rate. A microbial biocathode is a low-cost candidate, but suffers from a long startup and a low H(2) production rate. In this study, the effects of cathode potential and carbon source on microbial biocathode startup were investigated. Application of a more negative cathode potential did not decrease the startup time of the biocathode. If acetate instead of bicarbonate was used as carbon source, the biocathode started up more than two times faster. The faster startup was likely caused by a higher biomass yield for acetate than for bicarbonate, which was supported by thermodynamic calculations. To increase the H(2) production rate, a flow through biocathode fed with acetate was investigated. This biocathode produced 2.2 m(3) H(2) m(-3)  reactor day(-1) at a cathode potential of -0.7 V versus NHE, which was seven times that of a parallel flow biocathode of a previous study. Copyright © 2011 Wiley Periodicals, Inc.

  17. Success of Breast Cancer Startup Challenge Inspires Second Challenge | Poster

    Science.gov (United States)

    By Thomas Stackhouse, Joseph Conrad, and Michele Newton, Contributing Writers, and Rosemarie Truman, Guest Writer Sixty-one teams have been accepted into, and are now competing in, the Neuro Startup Challenge, a new collaboration established by the National Institutes of Health (NIH) with The Center for Advancing Innovation (CAI) and Heritage Provider Network, Inc.

  18. Startup : Philippine Community eCentres Network | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Startup : Philippine Community eCentres Network. More than 300 Community eCenters or telecentres are currently operating as part of local government units throughout the Philippines. Exchange visits with the M.S. Swaminathan Research Foundation of India have enabled these centres to evolve in such a way as to ...

  19. Startup : Jouw zoektocht naar een schaalbaar en herhaalbaar businessmodel

    NARCIS (Netherlands)

    Coelman, B. (Berrie)

    2014-01-01

    Dit ebook gaat over hoe je een kansrijke Startup wordt. Ongelooflijk veel wijsheid van veel deskundigen is samengekomen in dit (digitale) werkboek. Op verschillende manieren word je in dit boek uitgedaagd: invuloefeningen, lees - en nadenkwerk, schrijfopdrachten en toetsen van je verbeterde idee aan

  20. Start-up of a drinking water biofilter

    DEFF Research Database (Denmark)

    Ramsay, Loren; Søborg, Ditte; Breda, Inês Lousinha Ribeiro

    When virgin filter media is placed in drinking water biofilters, a start-up period of some months typically ensues. During this period, the necessary inorganic coating and bacterial community are established on the filter medium, after which the treated water complies with drinking water criteria...

  1. Evaluating effectiveness of project start-ups: an exploratory study

    NARCIS (Netherlands)

    Halman, Johannes I.M.; Burger, G.T.N.

    In this paper an exploratory study is reported about the effectiveness of project start-up (PSU) practices within a world-scale operating, high technology innovating and manufacturing company. The emphasis is on the focal position of both project owner and project manager. To uncover potential

  2. Dampak Mentoring Pada Keberhasilan Start-Up Business: Studi Kasus Pada Start-Up Business di Indonesia [Mentoring the Impact of Success of a Start-Up Business: A Case Study of a Start-Up Business in Indonesia

    Directory of Open Access Journals (Sweden)

    Christina Yanita Setyawati

    2016-10-01

    Full Text Available Entrepreneurship is a highly developed science today, as well as in the world of education in Indonesia. Teaching entrepreneurship at the university level, especially at some universities in Surabaya, the second largest city in Indonesia, shows the positive impact that there were 74.03% of start-up businesses that survived and thrived in 2014. Based on the previous observation, some business start-ups are accompanied by a mentor. Mentoring is a process of forming and maintaining lasting relationships that develop intensively among seniors with juniors. The mentoring function includes career and psychosocial functions. The main purpose of this research is to study the relationship between mentoring and the success of a start-up business. This study is a quantitative descriptive study using a random sampling method to obtain 100 samples. The tool used to collect data was a questionnaire. The methodology used to analyze the quantitative description to test the hypothesis. The results of this study indicate that mentoring influences the success of a start-up business that was owned by university students in Surabaya, Indonesia by 32% and 78% was influenced by other variables.

  3. Beta: An Experiment in Funded Undergraduate Start-Up

    Science.gov (United States)

    Jones, Paul; Forbes-Simpson, Kellie; Maas, Gideon; Newbery, Robert

    2015-01-01

    This paper reports on an evaluation of a funded undergraduate project designed to enable student business start-up. The programme, entitled "Beta", provides undergraduate students with £1,500 of seed-corn funding. The key objective of the project is for the participants to exit it with a viable and legal business entity through which…

  4. Localization effects of firm startups and closures in the Netherlands

    NARCIS (Netherlands)

    Huisman, Corina; van Wissen, L

    In this article localization trends as a result of startups and closures are investigated in the Netherlands, using a distance-based approach. A major advantage of this method is that it does not suffer from aggregation bias that is inherent in area-based methods. This method controls for the

  5. Start-Up Rhetoric in Eight Speeches of Barack Obama

    Science.gov (United States)

    O'Connell, Daniel C.; Kowal, Sabine; Sabin, Edward J.; Lamia, John F.; Dannevik, Margaret

    2010-01-01

    Our purpose in the following was to investigate the start-up rhetoric employed by U.S. President Barack Obama in his speeches. The initial 5 min from eight of his speeches from May to September of 2009 were selected for their variety of setting, audience, theme, and purpose. It was generally hypothesized that Barack Obama, widely recognized for…

  6. A Boom Time for Education Start-Ups

    Science.gov (United States)

    DeSantis, Nick

    2012-01-01

    Harsh economic realities mean trouble for college leaders. But where administrators perceive an impending crisis, investors increasingly see opportunity. In recent years, venture capitalists have poured millions into education-technology start-ups, trying to cash in on a market they see as ripe for a digital makeover. And lately, those wagers have…

  7. Foundations as Promoters of Life Science Start-ups

    National Research Council Canada - National Science Library

    Vonmont, Pascale

    2014-01-01

    .... One promising field is the very early-stage support for high-risk but high-potential business cases in order to increase the number of start-ups, not only but very often in the field of life sciences...

  8. Startup : Philippine Community eCentres Network | CRDI - Centre ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Startup : Philippine Community eCentres Network. More than 300 Community eCenters or telecentres are currently operating as part of local government units throughout the Philippines. Exchange visits with the M.S. Swaminathan Research Foundation of India have enabled these centres to evolve in such a way as to ...

  9. Reactive Systems

    DEFF Research Database (Denmark)

    Aceto, Luca; Ingolfsdottir, Anna; Larsen, Kim Guldstrand

    A reactive system comprises networks of computing components, achieving their goals through interaction among themselves and their environment. Thus even relatively small systems may exhibit unexpectedly complex behaviours. As moreover reactive systems are often used in safety critical systems, t...

  10. Iron: a versatile element to produce materials for environmental applications

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Ana Paula C.; Araujo, Maria H.; Oliveira, Luiz C.A.; Moura, Flavia C.C.; Lago, Rochel M., E-mail: rochel@ufmg.br, E-mail: anapct@ufmg.br [Departamento de Quimica, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil); Tristao, Juliana C. [Universidade Federal de Vicosa, Florestal, MG (Brazil); Ardisson, Jose D. [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil). Lab. de Fisica Aplicada; Amorim, Camila C., E-mail: juliana@ufv.br [Departamento de Engenharia Sanitaria e Ambiental, Universidade Federal de Minas Gerais, Belo Horizonte, MG (Brazil)

    2012-09-15

    Iron is a versatile element forming several phases with different oxidation states and {sup s}tructures, such as Fe{sup 0}, FeO, Fe{sub 3}O{sub 4}, {gamma}-Fe{sub 2}O{sub 3}, {alpha}-Fe{sub 2}O{sub 3} and FeOOH. All these phases have unique physicochemical properties which can be used for different applications. In this work, it is described the use of different iron compounds, synthetic and also from natural and waste sources, in environmental and technological applications. Two main research areas are described. The first one is related to strategies to increase the reactivity of Fe phases, mainly by the formation of Fe{sup 0}/iron oxide composites and by the introduction of new metals in the iron oxide structure to promote new surface reactions. The second area is the use of the magnetic properties of some iron phases to produce versatile magnetic materials with focus in adsorption, catalysis and emulsions. (author)

  11. Open innovation and the comparison between startups and incumbent firms in Spain

    DEFF Research Database (Denmark)

    Gimenez Fernandez, Elena Maria; Beukel, Karin

    2017-01-01

    This study compares the open innovation strategy between startups and incumbent firms over a period of ten years (2004-2013). Using a sample of startups and incumbent Spanish firms, we find that they differ considerably, and that this has implications for management. Incumbent firms and startups...... differ in terms of their use of external cooperation activities as a source of innovation. The lack of financial and human resources of startups leads them to open their borders more than incumbent firms, and startups benefit from being flexible, as they have yet to implement routines. This boosts...... startups’ innovation performance....

  12. Study of startup conditions of a pulsed annular reactor; Estudo das reacoes de partida de um reator anelar pulsado

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Mario Augusto Bezerra da

    2003-10-15

    A new concept of reactor, which combines features of pulsed and stationary reactors, was proposed so as to produce intense neutronic fluxes. Such a reactor, known as VICHFPR (Very Intense Continuous High Flux Pulsed Reactor), consists of a subcritical core with an annular geometry and pulsed by a rotating reflector which acts as a reactivity modulator as it produces a short pulse (approximately equal to 1 ms) of high intensity, guiding the region near the pulser to super-prompt critical state. This dissertation intends to analyze the startup conditions of a Pulsed Annular Reactor. The evolution of the neutron pulse intensity is analyzed when the reactivity modulator is brought upwards according to a helicoidal path from its initial position (far away from the core), when the multiplication factor has a subcritical value, up to the final position (near the core), in which a super-prompt critical state is reached. Part of the analysis is based on the variation of neutron reflection, which is a uniform function of the exit and reflection angles between the core and the modulator. It must be emphasized that this work is an approximation of the real situation. As the initial and final reactor parameters are known, a programming code in Fortran is worked out to provide the multiplication factor and the flux intensity evolution. According to the results obtained with this code, the conditions under which the modulator must be lifted up during the startup are established. Basically, these conditions are related to the analysis of the rising and the rotation velocities, the reflector saving and the initial distance between the reactor and the modulator. The Pulsed Annular Reactor startup was divided into three stages. Because of its negative reactivity in the first two stages, the neutron multiplication is not large, while the last one, having a positive reactivity, shows an intense multiplication as is usually expected when handling pulsed systems. This last stage is quite

  13. Dynamics and Control During Start-up of Energy Integrated Distillation Column

    DEFF Research Database (Denmark)

    Eden, Mario Richard; Koggersbøl, Arne; Hallager, L.

    2000-01-01

    To advocate the usage of process integration in industrial practice, it is important to be able to guarantee not only robust control during near steady state operation, but also to provide procedures for generating fast and reliable start-up sequences. This contribution concentrates on describing...... a systematic procedure for development of plant start-up sequences. The basis for the start-up procedure development is available qualitative process knowledge. Application of the start-up sequence generation procedure is demonstrated upon an energy integrated distillation plant. This plant illustrates some...... of the inherent effects of process integration upon a start-up procedure. In particular the effect of energy recycle upon the possible start-up sequence, and the effect of using an actuator f or control purposes, i.e. the heat pump, which in itself requires significant start-up time. The experimental application...

  14. Dynamics and Control During Start-Up of Energy Integrated Distillation Column

    DEFF Research Database (Denmark)

    To advocate the usage of process integration in industrial practice, it is important to be able to guarantee not only robust control during near steady state operation, but also to provide procedures for generating fast and reliable start-up sequences. This contribution concentrates on describing...... a systematic procedure for development of plant start-up sequences. The basis for the start-up procedure development is available qualitative process knowledge. Application of the start-up sequence generation procedure is demonstrated upon an energy integrated distillation plant. This plant illustrates some...... of the inherent effects of process integration upon a start-up procedure. In particular the effect of energy recycle upon the possible start-up sequence, and the effect of using an actuator for control purposes, i.e. the heat pump, which in itself requires significant start-up time. The experimental application...

  15. 40 CFR 60.1695 - What happens to the operating requirements during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... requirements during periods of startup, shutdown, and malfunction? 60.1695 Section 60.1695 Protection of... Requirements § 60.1695 What happens to the operating requirements during periods of startup, shutdown, and... municipal waste combustion unit startup, shutdown, or malfunction. (b) Each startup, shutdown, or...

  16. 40 CFR 60.1220 - What happens to the emission limits during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... during periods of startup, shutdown, and malfunction? 60.1220 Section 60.1220 Protection of Environment... Emission Limits § 60.1220 What happens to the emission limits during periods of startup, shutdown, and... waste combustion unit startup, shutdown, or malfunction. (b) Each startup, shutdown, or malfunction must...

  17. 40 CFR 62.15150 - What happens to the operating requirements during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... requirements during periods of startup, shutdown, and malfunction? 62.15150 Section 62.15150 Protection of... § 62.15150 What happens to the operating requirements during periods of startup, shutdown, and... municipal waste combustion unit startup, shutdown, or malfunction. (b) Each startup, shutdown, or...

  18. Versatile Protecting-Group Free Tetrazolomethane Amine Synthesis by Ugi Reaction.

    Science.gov (United States)

    Patil, Pravin; de Haan, Michel; Kurpiewska, Katarzyna; Kalinowska-Tłuścik, Justyna; Dömling, Alexander

    2016-03-14

    The use of ammonia in the Ugi reaction is often problematic due to low yields and multiple side reactions. Here, we report the use of ammonia in the tetrazole Ugi variation providing a clean, good-to-high yielding reaction, especially with ketones as oxo components. The scope and limitations of this reaction and a structure-reactivity relationship are provided by performing >85 reactions. The primary amine component of the α-amino tetrazole is a versatile starting material for further reactions.

  19. A reload and startup plan for conversion of the NIST research reactor

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, D. J. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-03-31

    The National Institute of Standards and Technology operates a 20 MW research reactor for neutron-based research. The heavy-water moderated and cooled reactor is fueled with high-enriched uranium (HEU) but a program to convert the reactor to low-enriched uranium (LEU) fuel is underway. Among other requirements, a reload and startup test plan must be submitted to the U.S. Nuclear Regulatory Commission (NRC) for their approval. The NRC provides guidance for what should be in the plan to ensure that the licensee has sufficient information to operate the reactor safely. Hence, a plan has been generated consisting of two parts. The reload portion of the plan specifies the fuel management whereby initially only two LEU fuel elements are in the core for eight fuel cycles. This is repeated until a point when the optimum approach is to place four fresh LEU elements into the reactor each cycle. This final transition is repeated and after eight cycles the reactor is completely fueled with LEU. By only adding two LEU fuel elements initially, the plan allows for the consumption of HEU fuel elements that are expected to be in storage at the time of conversion and provides additional qualification of production LEU fuel under actual operating conditions. Because the reload is to take place over many fuel cycles, startup tests will be done at different stages of the conversion. The tests, to be compared with calculations to show that the reactor will operate as planned, are the measurement of critical shim arm position and shim arm and regulating rod reactivity worths. An acceptance criterion for each test is specified based on technical specifications that relate to safe operation. Additional tests are being considered that have less safety significance but may be of interest to bolster the validation of analysis tools.

  20. A Reload and Startup Plan for and #8233;Conversion of the NIST Research Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Diamond, D. J. [Brookhaven National Lab. (BNL), Upton, NY (United States); Varuttamaseni, A. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2017-09-30

    The National Institute of Standards and Technology operates a 20 MW research reactor for neutron-based research. The heavy-water moderated and cooled reactor is fueled with high-enriched uranium (HEU) but a program to convert the reactor to low-enriched uranium (LEU) fuel is underway. Among other requirements, a reload and startup test plan must be submitted to the U.S. Nuclear Regulatory Commission (NRC) for their approval. The NRC provides guidance for what should be in the plan to ensure that the licensee has sufficient information to operate the reactor safely. Hence, a plan has been generated consisting of two parts.The reload portion of the plan specifies the fuel management whereby initially only two LEU fuel elements are in the core for eight fuel cycles. This is repeated until a point when the optimum approach is to place four fresh LEU elements into the reactor each cycle. This final transition is repeated and after eight cycles the reactor is completely fueled with LEU. By only adding two LEU fuel elements initially, the plan allows for the consumption of HEU fuel elements that are expected to be in storage at the time of conversion and provides additional qualification of production LEU fuel under actual operating conditions. Because the reload is to take place over many fuel cycles, startup tests will be done at different stages of the conversion. The tests, to be compared with calculations to show that the reactor will operate as planned, are the measurement of critical shim arm position and shim arm and regulating rod reactivity worths. An acceptance criterion for each test is specified based on technical specifications that relate to safe operation. Additional tests are being considered that have less safety significance but may be of interest to bolster the validation of analysis tools.

  1. Intellectual property in consumer electronics, software and technology startups

    CERN Document Server

    Halt, Jr , Gerald B; Stiles, Amber R; Fesnak, Robert

    2014-01-01

    This book provides a comprehensive guide to procuring, utilizing and monetizing intellectual property rights, tailored for readers in the high-tech consumer electronics and software industries, as well as technology startups.  Numerous, real examples, case studies and scenarios are incorporated throughout the book to illustrate the topics discussed.  Readers will learn what to consider throughout the various creative phases of a product’s lifespan from initial research and development initiatives through post-production.  Readers will gain an understanding of the intellectual property protections afforded to U.S. corporations, methods to pro-actively reduce potential problems, and guidelines for future considerations to reduce legal spending, prevent IP theft, and allow for greater profitability from corporate innovation and inventiveness. • Offers a comprehensive guide to intellectual property for readers in high-tech consumer electronics, software and technology startups; • Uses real case studies...

  2. Watts Bar Unit 2 Startup Results with VERA

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, Andrew T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Collins, Benjamin S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gentry, Cole A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ritchie, John A. [Tennessee Valley Authority (TVA), Knoxville, TN (United States)

    2017-03-01

    CASL members TVA, Westinghouse, and Oak Ridge National Laboratory have successfully completed a detailed simulation of the initial startup of Watts Bar Nuclear Unit 2 (WBN2) using the advanced reactor simulation tools known as VERA. WBN2 is the first commercial power reactor to join the nation’s electrical grid in over two decades, and the modern core design and availability of data make it an excellent benchmark for CASL. Calculations were performed three months prior to the startup, and in the first blind application of VERA to a new reactor, predicted criticality and physics parameters very close to those later measured by TVA. Subsequent calculations with the latest version of VERA and using exact measurement conditions improved the results even further.

  3. Startup and stability of thermophilic anaerobic digestion of OFMSW

    KAUST Repository

    El-Fadel, Mutasem E.

    2013-01-01

    Anaerobic digestion (AD) of the organic fraction of municipal solid waste (OFMSW) is promoted as an energy source and more recently as a greenhouse gas (GHG) mitigation measure. In this context, AD systems operating at thermophilic temperatures (55-60°C)-compared to mesophilic temperatures (35-40°C)-have the unique feature of producing hygienic soil conditioners with greater process efficiency, higher energy yield, and more GHG savings. Startup of AD systems is often constrained by the lack of acclimated seeds, leading to process instability and failure. The authors focus on strategies to startup thermophilic digesters treating OFMSW in the absence of acclimated seeds and examines constraints associated with process stability and ways to overcome them. Relevant gaps in the literature and future research needs are delineated. © 2013 Taylor & Francis Group, LLC.

  4. Lean Startup and Lean Canvas Using for Innovative Product Development

    Directory of Open Access Journals (Sweden)

    Alena Buchalcevová

    2016-06-01

    Full Text Available Recently, new approaches to product development have emerged that focus on idea generation techniques and customer itself. One of them is the Lean Startup method that is described in this article along with the Lean Canvas method. The main goal of the article is to demonstrate the application of both methods to an innovative product development focused on providing interactive trips for families with children. The development of the product during individual phases is described and application of the Lean Startup and Lean Canvas principles is demonstrated. Finally, benefits of both methods contributing to the product success are discussed. Similar case studies start emerging worldwide, however in the Czech context are quite rare.

  5. Fehlertoleranzanalyse des FlexRay Startup-Prozesses

    Science.gov (United States)

    Bünte, Sven; Milbredt, Paul

    Die PlexfiRay-Prozeduren Wakeup und Startup sollen eine konsistent-synchrone Kommunikation bezüglich eines TDMA verwandten Verfuhrens herstellen. Beide Algorithmen werden in dieser Arbeit ubstrukt modelliert und mit Hilfe des Model Checkers SPIN bezüglich Terminierung analysiert. Die Ergebnisse zeigen, dass in bestimmten Fehlerszenarios die Verwendung von Central Bus Guardians, die Clusterkonfiguration und das Verhalten des Hosts darüber entscheiden, ob Fehlertoleranz und Laufzeitbeschränkungen garantiert werden können.

  6. A Start-Up Demonstration Test Involving Distant Failures

    OpenAIRE

    Gera, Amos E.

    2013-01-01

    A new procedure for determining the acceptance or rejection of a system that undergoes a start-up demonstration set of tests is presented. It is a generalization of the recently introduced CSDF model (consecutive successes distant failures). According to the new total successes consecutive successes total failures distant failures (TSCSTFDF) procedure, a unit is accepted when either a total number of successful tests or a specified number of consecutive successes are observed before a total n...

  7. Strategy Development of PT XYZ a Startup Technology Company

    OpenAIRE

    Rahman, Leila Fatmasari; Mangkusubroto, Kuntoro; Sunitiyoso, Yos

    2012-01-01

    PT. XYZ (XYZ) is an Indonesian startup technology company which provides IT Consulting and System Integration services. In this research, XYZ's strategy for the next three years (until 2015) will be crafted by going through the strategic management process which consists of the following stages: (1) environment analysis of XYZ, (2) setting strategic vision, (3) setting objective, (4) crafting strategy and (5) executing the strategy. Based on the result of the environment analysis, XYZ's visio...

  8. Tokamak startup using point-source dc helicity injection.

    Science.gov (United States)

    Battaglia, D J; Bongard, M W; Fonck, R J; Redd, A J; Sontag, A C

    2009-06-05

    Startup of a 0.1 MA tokamak plasma is demonstrated on the ultralow aspect ratio Pegasus Toroidal Experiment using three localized, high-current density sources mounted near the outboard midplane. The injected open field current relaxes via helicity-conserving magnetic turbulence into a tokamaklike magnetic topology where the maximum sustained plasma current is determined by helicity balance and the requirements for magnetic relaxation.

  9. ECommerce Strategy for Footwear Manufacturing Start-up

    OpenAIRE

    Kuzmanovic, Slobodan

    2010-01-01

    This paper defines and analyzes an eCommerce strategy for a footwear manufacturing start-up firm and assesses the financial impact this eCommerce strategy has in supporting the firm’s business model. The market analysis of the importance of eCommerce determined the online channel’s market share and influence on consumer purchasing decisions, while the industry analysis examined the competitive landscape and industry forces as drivers of forward integration from manufacturing to wholesale and ...

  10. Webometrics for an Open Access Start-Up Journal (Editorial)

    OpenAIRE

    Ulf-Dietrich Reips; Uwe Matzat

    2009-01-01

    Before you stands the fourth issue of the International Journal of Internet Science. It will be the last one that is the only issue in its volume, because an increasing rate of manuscript submissions of high quality to this start-up journal forces us to jump to two issues next year. From citation analysis to webometrics Our citation analysis in the previous issue (Reips & Matzat, 2008) revealed a surprisingly high journal impact for the International Journal of Internet Science. To publish ve...

  11. Market Channels of Technology Startups that Internationalize Rapidly from Inception

    Directory of Open Access Journals (Sweden)

    Simar Yoos

    2012-10-01

    Full Text Available The study of technology startups that internationalize rapidly from inception has increased in recent years. However, little is known about their channels to market. This article addresses a gap in the "born global" literature by examining the channels used by six startups that internationalized rapidly from inception as well as the programs they used to support their channel partners and customers. The six startups examined combined the use of the Internet with: i a relationship with a multi-national, ii distributors, iii re-sellers, or iv a direct sales force. They also delivered programs to support partners and customers that focused on communications, alliance and network development, education, marketing and promotion, and financial incentives. This article informs entrepreneurs who need to design go-to-market channels to exploit global opportunities about decisions made by other entrepreneurs who launched born-global companies. Normative rules and practitioner-oriented approaches are needed to help entrepreneurs explain and apply the results presented in this article.

  12. Long Pulse EBW Start-up Experiments in MAST

    Directory of Open Access Journals (Sweden)

    Shevchenko V.F.

    2015-01-01

    Full Text Available Start-up technique reported here relies on a double mode conversion (MC for electron Bernstein wave (EBW excitation. It consists of MC of the ordinary (O mode, entering the plasma from the low field side of the tokamak, into the extraordinary (X mode at a mirror-polarizer located at the high field side. The X mode propagates back to the plasma, passes through electron cyclotron resonance (ECR and experiences a subsequent X to EBW MC near the upper hybrid resonance (UHR. Finally the excited EBW mode is totally absorbed at the Doppler shifted ECR. The absorption of EBW remains high even in cold rarefied plasmas. Furthermore, EBW can generate significant plasma current giving the prospect of a fully solenoid-free plasma start-up. First experiments using this scheme were carried out on MAST [1]. Plasma currents up to 33 kA have been achieved using 28 GHz 100kW 90ms RF pulses. Recently experimental results were extended to longer RF pulses showing further increase of plasma currents generated by RF power alone. A record current of 73kA has been achieved with 450ms RF pulse of similar power. The current drive enhancement was mainly achieved due to RF pulse extension and further optimisation of the start-up scenario.

  13. Patent Value: A Business Perspective for Technology Startups

    Directory of Open Access Journals (Sweden)

    Angela de Wilton

    2011-12-01

    Full Text Available In the last year, news headlines have highlighted record patent infringement settlements, multibillion dollar auctions of large corporate patent portfolios, and ongoing patent battles between key technology industry players. Despite this acknowledgment of the significant value of patents for large corporations, many small technology companies are understandably more focused on the near-term costs of obtaining a patent rather than future value. Costs may seem prohibitive to an early stage technology startup. Some software startups question whether patents are relevant to their business. In practice, effective intellectual property (IP strategy and management is dependent on many factors, such as technology or industry sector, size and maturity of the business, technology lifecycle, and the business and market environment. IP strategy must be aligned to business strategy from the outset. By considering IP in the broader context of the overall business plan and the competitive environment, opportunities for generating increased return on R&D investment and added business value through patents or other forms of IP can be recognized early on. This approach ensures that a decision about whether or not to patent is driven by business reasons rather than budget constraints. This article examines the costs and benefits of patents from the perspective of early-stage technology startups and growing businesses, and it provides some general guidance on best practices for developing an IP and patent activity plan and for building a patent portfolio that appropriately supports business objectives.

  14. Start-up and operating costs for artisan cheese companies.

    Science.gov (United States)

    Bouma, Andrea; Durham, Catherine A; Meunier-Goddik, Lisbeth

    2014-01-01

    Lack of valid economic data for artisan cheese making is a serious impediment to developing a realistic business plan and obtaining financing. The objective of this study was to determine approximate start-up and operating costs for an artisan cheese company. In addition, values are provided for the required size of processing and aging facilities associated with specific production volumes. Following in-depth interviews with existing artisan cheese makers, an economic model was developed to predict costs based on input variables such as production volume, production frequency, cheese types, milk types and cost, labor expenses, and financing. Estimated values for start-up cost for processing and aging facility ranged from $267,248 to $623,874 for annual production volumes of 3,402 kg (7,500 lb) and 27,216 kg (60,000 lb), respectively. First-year production costs ranged from $65,245 to $620,094 for the above-mentioned production volumes. It is likely that high start-up and operating costs remain a significant entry barrier for artisan cheese entrepreneurs. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  15. Feasibility study of ECRH in NSTX-U startup plasma

    Science.gov (United States)

    Lopez, N. A.; Poli, F.; Taylor, G.; Harvey, R.; Petrov, Yu.

    2016-10-01

    A key mission goal of the National Spherical Torus eXperiment Upgrade (NSTX-U) is the demonstration of fully non-inductive startup and operation. In part to accomplish this, a 1MW, 28 GHz ECRH system is presently being developed for implementation on NSTX-U in 2018. Like most spherical tokamaks, NSTX-U operates in the overdense regime (fpe>fce) , which limits traditional ECRH to the early startup phase. An extensive modelling effort of the propagation and absorption of EC waves in the evolving plasma is thus required to define the most effective window of operation, and to optimize the launcher geometry for maximal heating and for current drive during this window. In fact, the ECRH system will play an important role in preparing a target plasma for subsequent injection of IC waves and NBI. Here we assess the feasibility of O1-mode ECRH in NSTX-U startup plasma at full field of 1T through time-dependent simulations performed with the transport solver TRANSP. Linear ray-tracing calculations conducted by GENRAY are coupled into the TRANSP framework, allowing the plasma equilibrium and the temperature profiles to evolve self-consistently in response to the injected microwave power. Furthermore, we investigate additional possibilities of heating and current drive made available through coupling the injected O-mode power to the electrostatic EBW via the slow X-mode as an intermediary.

  16. Guinea Pigs: Versatile Animals for the Classroom

    Science.gov (United States)

    Barman, Charles R.

    1977-01-01

    Guinea pigs are presented as versatile classroom animals. Suggestions for animal behavior and genetics studies are given. Also included is information concerning sex determination and the breeding of guinea pigs, and hints on keeping these animals in the classroom. References and illustrations complete the article. (MA)

  17. A Versatile Technique for Solving Quintic Equations

    Science.gov (United States)

    Kulkarni, Raghavendra G.

    2006-01-01

    In this paper we present a versatile technique to solve several types of solvable quintic equations. In the technique described here, the given quintic is first converted to a sextic equation by adding a root, and the resulting sextic equation is decomposed into two cubic polynomials as factors in a novel fashion. The resultant cubic equations are…

  18. Versatility of nodal affiliation to communities.

    Science.gov (United States)

    Shinn, Maxwell; Romero-Garcia, Rafael; Seidlitz, Jakob; Váša, František; Vértes, Petra E; Bullmore, Edward

    2017-06-27

    Graph theoretical analysis of the community structure of networks attempts to identify the communities (or modules) to which each node affiliates. However, this is in most cases an ill-posed problem, as the affiliation of a node to a single community is often ambiguous. Previous solutions have attempted to identify all of the communities to which each node affiliates. Instead of taking this approach, we introduce versatility, V, as a novel metric of nodal affiliation: V ≈ 0 means that a node is consistently assigned to a specific community; V > 0 means it is inconsistently assigned to different communities. Versatility works in conjunction with existing community detection algorithms, and it satisfies many theoretically desirable properties in idealised networks designed to maximise ambiguity of modular decomposition. The local minima of global mean versatility identified the resolution parameters of a hierarchical community detection algorithm that least ambiguously decomposed the community structure of a social (karate club) network and the mouse brain connectome. Our results suggest that nodal versatility is useful in quantifying the inherent ambiguity of modular decomposition.

  19. BUSINESS PLANNING STARTUPS IN CONTEXT, ATTRACTING VENTURE CAPITAL INVESTMENT

    Directory of Open Access Journals (Sweden)

    V. A. Vernikov

    2014-01-01

    Full Text Available The topic of this article is relevant, as the hallmark of innovative business development inRussiais a gradual but steady transition from uncivilized forms of business to the latest international study using the methods and tools of business planning. As the experience of western businessmen prerequisite for the success of creating a business from scratch, is to develop a business plan that allows you to specify how the essence and purpose of the project and the number of required investment funds.Purpose / Objectives. The aim of the article is to analyze the theoretical and methodological foundations of business planning for startups to attract venture capital investment based on the study of foreign experience. Objectives of the article: consider the theoretical basis for planning a startup; - To analyze the experience of entrepreneurs planning a startup in Western countries.Methodology. Methodological basis of this article appeared comparative and structural analysis methods.Results. Preparing a business plan for a startup project is a complex and labor-intensive process, where the business plan is a business card needed to attract external funding, the road map for the initiator of the project, so its preparation no trifl es. As the experience of western businessmen, errors that may have occurred during the development of a business plan: the unreliability and incompleteness of the input information; ignoring the need to prepare an analysis of the market or use in its preparation unreliable sources; errors in the calculations carried out, their incompleteness; errors in the text part of the business plan, as well as non-compliance with the logic of the material, its scarcity, unprofessional calculations; lack of risk analysis. With the right approach to the preparation of a business plan it can be not only a formal document, but also a practical guide to the implementation of business ideas that will allow for timely assessment of the impact

  20. [Reactive arthritis].

    Science.gov (United States)

    Gerloni, V; Fantini, F

    1990-01-01

    The term reactive arthritis was introduced to describe an acute non-purulent arthritis complicating an infection elsewhere in the body. Reactive arthritis can also be classified into HLA-B27 associated and non-associated forms. Rheumatic fever is an example of the HLA-B27 non-associated forms with genetic factors other than HLA-B27 involved. HLA-B27 associated reactive arthritis includes enteric, urogenic and idiopathic arthritides. The bacteria known to trigger post-enteritic reactive arthritis are: Yersinia, Salmonella, Shigella, Campylobacter, Clostridium difficile and Brucella; those known to trigger post-urethritic reactive arthritis are Chlamydia trachomatis and Ureaplasma urealyticum, but often the germ remains unidentified. Mechanisms through which susceptibility to reactive arthritis is linked to HLA-B27 antigen are still incompletely understood, but a clue could be cross-reactivity between B27 and a surface antigen of pathogenic germs. The clinical profile of the disease is characterized by an asymmetrical oligoarthritis with involvement particularly of the peripheral joints of the lower limbs. The arthritis generally recovers without sequelae within a few weeks or months. Accompanying features can be the involvement of enthesis and tendon sheets in form of a talalgia or dactylitis. In some cases the arthritis can relapse and chronicize. In some cases, in addition, involvement of the axial skeleton can occur (spondylitis and/or sacroiliitis). Another feature of the disease is the frequent association with typical extra-articular manifestations such as uveitis and muco-cutaneous lesions.

  1. The start-up analysis of a PEM fuel cell system in vehicles

    DEFF Research Database (Denmark)

    Rabbani, Raja Abid; Rokni, Masoud; Hosseinzadeh, Elham

    2014-01-01

    results for start-up scenario are presented. It is shown that system stability is influenced by slow thermal management controls. High loads at start-up affect voltage and system efficiency adversely. Cathode inlet water levels are found to be adequate for humidification of recirculated fuel stream....... Liquid water at cathode outlet is considerably higher at high current density start-ups, pertaining to water removal issues. © 2013 Copyright Taylor and Francis Group, LLC....

  2. Agile metodologies use for software development in Slovenian start-ups

    OpenAIRE

    Kašnik, Matic

    2014-01-01

    The thesis presents and describes the use of agile methodologies which are being used by Slovenian tech start-up companies. It describes the basic features, advantages and disadvantages of various agile methodologies such as Scrum, extreme programming, lean start-up and method Kanban. We made a review of the most used agile methodologies in Slovenian technology start-up companies. In particular, we focus on variety of tools, technics and approaches used by the development teams and where do t...

  3. Impact of chemical plant start-up emissions on ambient ozone concentration

    Science.gov (United States)

    Ge, Sijie; Wang, Sujing; Xu, Qiang; Ho, Thomas

    2017-09-01

    Flare emissions, especially start-up flare emissions, during chemical plant operations generate large amounts of ozone precursors that may cause highly localized and transient ground-level ozone increment. Such an adverse ozone impact could be aggravated by the synergies of multiple plant start-ups in an industrial zone. In this paper, a systematic study on ozone increment superposition due to chemical plant start-up emissions has been performed. It employs dynamic flaring profiles of two olefin plants' start-ups to investigate the superposition of the regional 1-hr ozone increment. It also summaries the superposition trend by manipulating the starting time (00:00-10:00) of plant start-up operations and the plant distance (4-32 km). The study indicates that the ozone increment induced by simultaneous start-up emissions from multiple chemical plants generally does not follow the linear superposition of the ozone increment induced by individual plant start-ups. Meanwhile, the trend of such nonlinear superposition related to the temporal (starting time and operating hours of plant start-ups) and spatial (plant distance) factors is also disclosed. This paper couples dynamic simulations of chemical plant start-up operations with air-quality modeling and statistical methods to examine the regional ozone impact. It could be helpful for technical decision support for cost-effective air-quality and industrial flare emission controls.

  4. Startup-vaiheen ekosysteemi : Yrityksen alkuvaiheen yrittäjän ekosysteemi ja liiketoimintaekosysteemi

    OpenAIRE

    Hakola, Jennika

    2015-01-01

    Opinnäytetyön tavoitteena oli tutkia millainen on startup-vaiheen ekosysteemi. Tavoitteena oli tutkia millainen on startup-vaiheen liiketoimintaekosysteemi ja millainen on yrittäjän startup-vaiheen ekosysteemi. Työn tavoitteena oli luoda malli siitä, millaisena kokonaisuutena yrittäjät kokevat startup-vaiheen ekosysteemin. Opinnäytetyön teoreettisessa viitekehyksessä käsitellään liike-elämässä, uutta ja nousevaa käsitettä: liiketoimintaekosysteemi, joka hakee mallia biologisesta ekosystee...

  5. Novel start-up circuit with enhanced power-up characteristic for bandgap references

    DEFF Research Database (Denmark)

    Tuan Vu, Cao; Wisland, Dag T.; Lande, Tor Sverre

    This paper presents a new start-up circuit for low-power bandgap reference (BGR) voltage generators. The BGR is designed for providing a stable 0.3 V power supply for application in low power wireless sensor nodes. The BGR has an enhanced power-up characteristic and demonstrates a reduction...... of the total stand-by current. Simulated results confirm that the proposed start-up circuit does not affect the performance of the BGR even though the supply voltage (VDD) is higher and has more stable power-up characteristic than the conventional start-up circuits. The new start-up circuit is designed with 65...

  6. Start-Up Size Strategy and Risk Management: Impact on New Venture Performance

    OpenAIRE

    André van Stel; Andrew Burke; José Maria Millán; Concepcion Roman

    2013-01-01

    Start-up size is a key strategic decision for entrepreneurs. Should entrepreneurs start up close to minimum efficient scale or should they take less risks and start-up on a smaller scale? Previously, this strategic decision appeared to be one of simply making a choice between a higher risk/reward larger start-up versus a lower risk/reward smaller scale start-up. However, recent research on the relationship between risk management and performance (Burke, 2009) indicates that in situations of g...

  7. The Versatile Link Demo Board (VLDB)

    Science.gov (United States)

    Martín Lesma, R.; Alessio, F.; Barbosa, J.; Baron, S.; Caplan, C.; Leitao, P.; Pecoraro, C.; Porret, D.; Wyllie, K.

    2017-02-01

    The Versatile Link Demonstrator Board (VLDB) is the evaluation kit for the radiation-hard Optical Link ecosystem, which provides a 4.8 Gbps data transfer link for communication between front-end (FE) and back-end (BE) of the High Energy Physics experiments. It gathers the Versatile link main radiation-hard custom Application-Specific Integrated Circuits (ASICs) and modules: GBTx, GBT-SCA and VTRx/VTTx plus the FeastMP, a radiation-hard in-house designed DC-DC converter. This board is the first design allowing system-level tests of the Link with a complete interconnection of the constitutive components, allowing data acquisition, control and monitoring of FE devices with the GBT-SCA pair.

  8. Reactive Systems

    DEFF Research Database (Denmark)

    Aceto, Luca; Ingolfsdottir, Anna; Larsen, Kim Guldstrand

    A reactive system comprises networks of computing components, achieving their goals through interaction among themselves and their environment. Thus even relatively small systems may exhibit unexpectedly complex behaviours. As moreover reactive systems are often used in safety critical systems......, the need for mathematically based formal methodology is increasingly important. There are many books that look at particular methodologies for such systems. This book offers a more balanced introduction for graduate students and describes the various approaches, their strengths and weaknesses, and when...

  9. Reactive Systems

    DEFF Research Database (Denmark)

    Aceto, Luca; Ingolfsdottir, Anna; Larsen, Kim Guldstrand

    A reactive system comprises networks of computing components, achieving their goals through interaction among themselves and their environment. Thus even relatively small systems may exhibit unexpectedly complex behaviours. As moreover reactive systems are often used in safety critical systems, t...... into account. The book has arisen from various courses taught in Denmark and Iceland and is designed to give students a broad introduction to the area, with exercises throughout....

  10. How versatile are inositol phosphate kinases?

    OpenAIRE

    Shears, Stephen B.

    2004-01-01

    This review assesses the extent and the significance of catalytic versatility shown by several inositol phosphate kinases: the inositol phosphate multikinase, the reversible Ins(1,3,4) P (3)/Ins(3,4,5,6) P (4) kinase, and the kinases that synthesize diphosphoinositol polyphosphates. Particular emphasis is placed upon data that are relevant to the situation in vivo. It will be shown that catalytic promiscuity towards different inositol phosphates is not typically an evolutionary compromise, bu...

  11. Isatin, a versatile molecule: studies in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Barbara, E-mail: barbara.iq@gmail.com [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil)

    2013-05-15

    Isatin is a small, versatile and widely applicable pharmacological molecule. These characteristics make isatin and its derivatives attractive to many research groups as resources for chemical and pharmacological studies. Although it has a relatively simple structure, isatin is a useful chemical scaffold for a variety of chemical transformations. This article discusses several studies performed by Brazilian groups, including investigations of its structural changes, biological assay designs and new methods for the synthesis of isatin. (author)

  12. Success and Failure in University-Based Startups

    Science.gov (United States)

    Dehn, J.; Webley, P.; Cunningham, K. W.

    2014-12-01

    Adapting from a traditional government-funded research program to supporting the work through a start-up company is a difficult (and often not successful) transition. This is made more challenging in that with the relative decline in federal funding for the sciences the transition is forced on many researchers as a matter of survival. The business model of traditional research is not that different from that of the private sector; the development of an idea, models or mock-ups of the product, pitching to sources of funding, creating and marketing the product. However they differ significantly in the environment in which they are applied, as well as in the life span of a project or product. The environments for pitching an idea and gaining investment are very different in academia from that of the private sector, and most academics are stymied by the new approach. In addition, many universities labor under the illusion that start-ups will be a windfall, when in reality they represent a long term investment that will not pay out for many years. This extended timeline is also something new to academics, though persistence pays and a project may take years to fund, after it is complete and the publications written, many in the geosciences go on to new ideas. If a business is to be successful it must continue with a product long term, and develop new ideas around it. A hopefully successful balance of these approaches is being tried at the University of Alaska Fairbanks, where start-ups can build upon university intellectual property and use university resources to build a successful business. In turn the business supports research and development, primarily through faculty, staff and students at the university.

  13. Bootstrap finance: the art of start-ups.

    Science.gov (United States)

    Bhide, A

    1992-01-01

    Entrepreneurship is more popular than ever: courses are full, policymakers emphasize new ventures, managers yearn to go off on their own. Would-be founders often misplace their energies, however. Believing in a "big money" model of entrepreneurship, they spend a lot of time trying to attract investors instead of using wits and hustle to get their ideas off the ground. A study of 100 of the 1989 Inc. "500" list of fastest growing U.S. start-ups attests to the value of bootstrapping. In fact, what it takes to start a business often conflicts with what venture capitalists require. Investors prefer solid plans, well-defined markets, and track records. Entrepreneurs are heavy on energy and enthusiasm but may be short on credentials. They thrive in rapidly changing environments where uncertain prospects may scare off established companies. Rolling with the punches is often more important than formal plans. Striving to adhere to investors' criteria can diminish the flexibility--the try-it, fix-it approach--an entrepreneur needs to make a new venture work. Seven principles are basic for successful start-ups: get operational fast; look for quick break-even, cash-generating projects; offer high-value products or services that can sustain direct personal selling; don't try to hire the crack team; keep growth in check; focus on cash; and cultivate banks early. Growth and change are the start-up's natural environment. But change is also the reward for success: just as ventures grow, their founders usually have to take a fresh look at everything again: roles, organization, even the very policies that got the business up and running.

  14. Business Plan for a Startup Company VRDA | HELSINKI

    OpenAIRE

    Bergström, Bettina

    2012-01-01

    The Bachelor’s thesis in question is composed to help the founders of a startup company called VRDA | HELSINKI to discover a successful path to a sustainable business. The author of the thesis is one of the two co-founders of the company and therefore, the process of writing the business plan is planned to function as a great tool for receiving an in-depth understanding about the business processes and to evoke ideas how to cultivate the business. Since the business plan is written alongside ...

  15. Research Strategies in Science-based Start-ups

    DEFF Research Database (Denmark)

    Valentin, Finn; Dahlgren, Johan Henrich; Lund Jensen, Rasmus

    instead the attention to the quality of their science, or the roles of boards, management, and collaborative networks etc. Using a unique comprehensive dataset on Danish and Swedish biotech start-ups in drug discovery this paper analyzes their research strategies. Adopting a Simonean point of departure we...... developed as congruent responses to problem architectures; 3) Testing and confirming that financial valuation of firms is driven by achievements conforming to requisite research strategies. These strategies, in turn, require careful combination of multiple dimensions of research.Findings demonstrate...

  16. Royal Society offers funds for technology start-ups

    Science.gov (United States)

    Clery, Daniel

    2008-04-01

    Scientists with a good idea ripe for commercial exploitation will no longer have to hawk their wares to bankers and private investors to get financial backing: the Royal Society is also about to get into the venture-capital business. The society is planning to set up an enterprise fund to buy equity in start-up companies based on outstanding technology - covering everything from renewable energy and carbon capture to water purification. "If there are difficulties getting science into the marketplace, the society has a role helping with that," says chemical physicist Andrew Mackintosh, a former chief executive of Oxford Instruments who has been brought in to manage the fund.

  17. Blogging business step-by-step startup guide

    CERN Document Server

    magazine, Entrepreneur

    2014-01-01

    This kit includes: Essential industry and business-specific startup steps with worksheets, calculators, checklists and more. Entrepreneur Editors' Start Your Own Business, a guide to starting any business and surviving the first three years. Downloadable, customizable business letters, sales letters, and other sample documents. Entrepreneur's Small Business Legal Toolkit. Blogs are still one of the internet's fastest-growing phenomena–and one of the best and easiest ways to make money online. Packed with the latest blog tools, tricks, and up-and-coming trends, this fully revised edition teache

  18. Sustainability Strategies for Regional Health Information Organization Startups

    DEFF Research Database (Denmark)

    Winkler, Till J.; Ozturk, Pinar; Brown, Carol V.

    2016-01-01

    HIOs that became operational during the SHIECAP grant period faced similar startup challenges, the two HIOs that demonstrated sustainability pursued distinct technology and sustainability strategies to develop HIE capabilities to fit their very different regional needs: an HIE capability to improve...... the population health of an underserved urban population, and an HIE capability to enable the transition to a healthcare landscape that rewards care coordination across suburban hospitals and physician practices. Conclusions: We propose two models of technology and sustainability strategies for developing bottom...

  19. NEW VENTURE CREATION: HOW START-UPS GROW?

    Directory of Open Access Journals (Sweden)

    AIDIN SALAMZADEH

    Full Text Available ABSTRACT Start-ups, often seen as sources of innovation and change, are prone to failure and accordingly they are attracting considerable attention not least from policy makers and Government officials. However, the various new venture creation studies that have emerged since the early 1980s lack cohesiveness, and the domain remains controversial. This article not only exposes the limitations of the existing body of understanding on the topic but attempts to develop a more comprehensive and comprehendible framework for start up (new venture creation. To do so it uses the frameworks proposed by Whetten, and March and Smith to develop 11 propositions. The resultant model suggests that the creation of a start up involves the identification of an idea or opportunity by an entrepreneur who subsequently organizes a series of activities, mobilizes resources and creates competence using his/her networks in an environment in order to create value. It sheds light on the start-up (new venture creation process and has relevance for entrepreneurs, policy makers and researchers.

  20. Start-up analysis for automotive PEM fuel cell systems

    Science.gov (United States)

    De Francesco, M.; Arato, E.

    The development of fuel cell cars can play an important role in resolving transport problems, due to the high environmental compatibility and high efficiency of this kind of vehicle. Among the different types of fuel cells, proton-exchange membrane fuel cells (PEMFCs) are considered the best solution for automotive applications at the moment. In this work, constructive criteria are discussed with the aim of obtaining a power generation module adaptable to a wide range of cars. A particular problem in accomplishing the overall project is represented by the definition of the compressor system for air feeding. In this work, the design approach to the problem will be delineated: some options are reviewed and the best solution is analysed. The transient response of the system (fuel cell and compressor) is investigated in order to optimise the start-up running through a model of a fuel cell stack and a compressor simulation. The model and its results are proposed as a work procedure to solve the problem, by varying external conditions: in fact, to perform the system start-up under stable conditions, the air relative humidity and temperature must be maintained in a proper range of values. The approach here presented has been utilised for the definition of the characteristics of the power module and layout of a middle-size hybrid city bus in the framework of a project promoted by the European Union.

  1. A Studio Based Approach to Enhancing Decision Making in Sme Start-Up

    NARCIS (Netherlands)

    Sol, H G; Ejiri, A.H.; Nabukenya, J.

    2011-01-01

    The start-up phase plays an important role in the success and survival of many enterprises, which greatly depends on adequate and timely services for decision making. However, deciding to startup a mining Small and Medium Enterprise (SME) is a challenging task for many entrepreneurs in Uganda.

  2. What Technology Startups Must Get Right to Globalize Early and Rapidly

    Directory of Open Access Journals (Sweden)

    Tony Bailetti

    2012-10-01

    Full Text Available Upon or shortly after inception, growth-oriented technology startups must operate in a market that is global. Management teams and investors of technology startups can benefit from approaches and models that can help them operate in a global market early and rapidly. How well a technology startup addresses the realities of globalization will determine its success. A better understanding of what management teams and investors of technology startups must get right to globalize their startups is needed. This article is an attempt to meet this need. In this article, lessons that have been extracted from six literature streams and from information on 21 startups founded in 12 countries are used to identify the six elements that a startup must get right to globalize early and rapidly. These six elements are: i Problem scope, ii Stakeholders’ commitments, iii Collaborative entrepreneurship, iv Relational capital, v Legitimacy, and vi Global capability. The main contribution of this article is that it throws the spotlight on the need to develop prescriptive rules and practitioner-oriented models that can help a technology startup operate globally from an early stage.

  3. Start-up of a UASB effluent treatment plant on distillery wastewater ...

    African Journals Online (AJOL)

    This paper reports on the seasonal operation of a UASB treatment plant treating a distillery wastewater stream with particular focus on seasonal start-up conditions after the first process commissioning. The start-up period was typically one week before process stability could be achieved. It is recommended that the loading ...

  4. Network brokers or hit makers? Analyzing the influence of incubation on start-up investments

    NARCIS (Netherlands)

    Van Rijnsoever, Frank J.|info:eu-repo/dai/nl/314100334; Van Weele, Marijn A.; Eveleens, Chris P.|info:eu-repo/dai/nl/369284704

    Incubators are a prominent way to support technology based start-ups. Yet, it remains unclear to what extent these incubators enhance start-up performance, nor is it known through which mechanisms this would occur. In this paper we test two mechanisms to explain the relationship between incubation

  5. Navigating the Interface between Design Education and Fashion Business Start-up

    Science.gov (United States)

    Mills, Colleen E.

    2012-01-01

    Purpose: The purpose of this paper is to address the interface between design education and business start-up in the designer fashion industry (DFI) and provide a new framework for reflecting on ways to improve design education and graduates' business start-up preparedness. Design/methodology/approach: This interpretive study employed…

  6. Kinetic start-up performance of two large treatment plants for nutrient removal

    DEFF Research Database (Denmark)

    Haarbo, A.; Harremoës, Poul; Thirsing, C.

    2001-01-01

    of the start-up of the two full-scale plants with the main emphasis laid on the kinetic performance in relation to the information achieved from the pilot tests. The results showed that the start-up of the full scale plants proceeded with great accuracy as expected from the investigations. Accordingly...

  7. Start-up strategies of membrane-aerated biofilm reactor (MABR) for completely autotrophic nitrogen removal

    DEFF Research Database (Denmark)

    Sun, Sheng-Peng; Pellicer i Nàcher, Carles; Terada, Akihiko

    2009-01-01

    downside of this process stems from a long start-up period due to the slow growth rate of AnAOB. Therefore, two different start-up strategies, i.e., continuous inoculation of AnAOB and sequential batch inoculation of AOB and AnAOB, were tested in two laboratory scale membrane-aerated biofilm reactor (MABRs...

  8. Going Boldly Into the Future: Skills and Australian High Technology Start-Up Firms.

    Science.gov (United States)

    Whittingham, Karen

    The skill needs of Australian high-technology start-up companies and the implications of those skill needs for vocational education and training (VET) were examined through a study of 14 start-ups' inherent abilities to access the VET system and on VET's relevance to their needs. The case studies documented a strong demand and role for VET in the…

  9. Help Wanted: Exploring the Value of Entrepreneurial Mentoring at Start-Up

    Science.gov (United States)

    Brodie, Jacqueline; Van Saane, Sebastiaan Huib; Osowska, Renata

    2017-01-01

    The purpose of the research presented in this article was to investigate the added value of mentoring for entrepreneurs during the start-up phase. This small-scale exploratory research focused on five start-up entrepreneurs in Scotland to determine the entrepreneurs' perceptions regarding the "added" value of their mentoring support. To…

  10. Manual of Considerations and Techniques for Start-Up of Municipal Wastewater Treatment Facilities.

    Science.gov (United States)

    Rader, R. D.; And Others

    This manual provides guidance for putting into initial operation a new municipal wastewater treatment plant, a new addition to an existing treatment plant, or a change in the mode of a treatment plant's operation. Information is provided on preparing for actual treatment plant start-up. Preparation for start-up includes: staffing the plant,…

  11. 76 FR 50887 - Elections Regarding Start-Up Expenditures, Corporation Organizational Expenditures, and...

    Science.gov (United States)

    2011-08-17

    ... expenses and provide guidance on how to elect to deduct the expenses in accordance with the new rules... make an election to capitalize start-up and organizational costs must ``affirmatively elect to... general. Under section 195(b), a taxpayer may elect to amortize start-up expenditures as defined in...

  12. The Emergence of the Lean Global Startup as a New Type of Firm

    Directory of Open Access Journals (Sweden)

    Erik Stavnsager Rasmussen

    2015-11-01

    Full Text Available This article contributes to the interplay between international entrepreneurship, innovation networks, and early internationalization research by emphasizing the need to conceptualize and introduce a new type of firm: the lean global startup. It discussed two different paths in linking the lean startup and born-global internationalization strategies. The first path refers to generic lean startups that have undertaken a rapid internationalization strategy (i.e., lean-to-global startups. The second path refers to startups that have started operating on global scale since their inception and adopted the lean startup approach by seamlessly synergizing their global and lean product development activities. The article emphasizes several aspects that could be used as part of the theoretical foundation for conceptualizing lean global startups as a special new type of firm: i the emergent nature of their business models, including the challenges of partnership development on a global scale; ii the inherently relational nature of the global resource allocation processes; iii the integration of the entrepreneurial, effectuation, and global marketing perspectives; iv the need to deal with a high degree of uncertainty, including the uncertainty associated with cross-border business operations; and v linking the ex-ante characteristics of lean startups with the ex-post characteristics of born-global firms in order to develop a technology adoption marketing perspective that considers the “crossing the chasm” process as a successful entry into a global market niche.

  13. Storytelling at Its Best: Using the StartUp Podcast in the Classroom

    Science.gov (United States)

    Teckchandani, Atul; Obstfeld, David

    2017-01-01

    This article discusses the virtues of using podcasts in the classroom by focusing on the pedagogical merits of one podcast: StartUp. The StartUp podcast provides a compelling first-person account of the entrepreneurial journey, as told by an award-winning radio journalist. Episodes from the podcast can be used to engage students and improve their…

  14. Leadership toward Creativity in Virtual Work in a Start-Up Context

    Science.gov (United States)

    Humala, Iris Annukka

    2015-01-01

    Purpose: This paper aims to better understand how to lead toward creativity in virtual work in a start-up context. Design/methodology/approach: The study investigates the participants' experiences about the learning challenges in leadership toward creativity in virtual work in a start-up company and the meanings attributed to their experiences,…

  15. Start-ups, long- and short-term survivors, and their contribution to employment growth

    NARCIS (Netherlands)

    Fritsch, Michael; Noseleit, Florian

    This study documents that the survival of start-ups is central in explaining the relationship between entry and regional employment growth. Distinguishing between start-ups according to the period of their survival shows that the positive effect of new business formation on employment growth is

  16. Resourcing Lab Experiments for New Ventures: The Potential of a Start-Up Database

    Science.gov (United States)

    Pietrobon, Alberto

    2009-01-01

    This article responds to "Laboratory experiments as a tool in the empirical economic analysis of high-expectation start-ups" by Martin Curley and Piero Formica, published in the December 2008 issue of "Industry and Higher Education". Curley and Formica introduce a new concept for high-expectation start-ups, involving the use of "laboratory…

  17. Successful IT Start-Ups' HRD Practices: Four Cases in South Korea

    Science.gov (United States)

    Cho, Yonjoo; McLean, Gary N.

    2009-01-01

    Purpose: The purpose of this paper is to identify South Korea's successful IT start-ups' HRD practices to determine whether there are steps that must be taken to maintain their HRD expertise for continued growth. Design/methodology/approach: A case study approach employing four fast-growing IT start-up cases was undertaken based on semi-structured…

  18. The Ecosystem of Startups as a Component of the Innovation Ecosystem

    Directory of Open Access Journals (Sweden)

    Sytnik Natalia I.

    2017-08-01

    Full Text Available The article analyzes the current theoretical perceptions of the ecosystem of startups and presents the author’s own vision of this entity. It has been proposed to consider the ecosystem of startups as a subsystem of the innovation ecosystem, which aims at creating innovative products and services by startup companies. The ecosystem of startups is an open dynamic system in which the backbone subject is a startup company at various stages of the life cycle. The sustenance subjects in an ecosystem are the organizations, associations and individuals that cause impacts, to varying degrees, on the establishing or development of startups. The activities of the subjects are carried out in the following directions: public regulation, financing, training, information, and infrastructure support for startups. The ecosystem consists of a number of economic, material-and-technical, market, and socio-cultural factors that directly or indirectly influence the actions of the subjects. The vital activity of the ecosystem of startups is maintained by the active interaction of the subjects, connected by a network of internal links with the environment and between themselves.

  19. Reactive arthritis.

    Science.gov (United States)

    Keat, A

    1999-01-01

    Reactive arthritis is one of the spondyloarthropathy family of clinical syndromes. The clinical features are those shared by other members of the spondyloarthritis family, though it is distinguished by a clear relationship with a precipitating infection. Susceptibility to reactive arthritis is closely linked with the class 1 HLA allele B27; it is likely that all sub-types pre-dispose to this condition. The link between HLA B27 and infection is mirrored by the development of arthritis in HLA B27-transgenic rats. In this model, arthritis does not develop in animals maintained in a germ-free environment. Infections of the gastrointestinal, genitourinary and respiratory tract appear to provoke reactive arthritis and a wide range of pathogens has now been implicated. Although mechanistic parallels may exist, reactive arthritis is distinguished from Lyme disease, rheumatic fever and Whipple's disease by virtue of the distinct clinical features and the link with HLA B27. As in these conditions both antigens and DNA of several micro-organisms have been detected in joint material from patients with reactive arthritis. The role of such disseminated microbial elements in the provocation or maintenance of arthritis remains unclear. HLA B27-restricted T-cell responses to microbial antigens have been demonstrated and these may be important in disease pathogenesis. The importance of dissemination of bacteria from sites of mucosal infection and their deposition in joints has yet to be fully understood. The role of antibiotic therapy in the treatment of reactive arthritis is being explored; in some circumstances, both the anti-inflammatory and anti-microbial effects of certain antibiotics appear to be valuable. The term reactive arthritis should be seen as a transitory one, reflecting a concept which may itself be on the verge of replacement, as our understanding of the condition develops. Nevertheless it appropriately describes arthritis that is associated with demonstrable

  20. Pengaruh Faktor Keuangan dan Non-keuangan Mencapai Keberhasilan Start-up Bisnis [Factors Influencing Financial and Non-Financial Start-up Business Success

    Directory of Open Access Journals (Sweden)

    Sri Nathasya Br Sitepu

    2015-09-01

    Full Text Available Business start-up is the term used for the many new efforts applied when business growth is fairly rapid. The success of start-up businesses can be measured by financial and non-financial factors. Financial factors are reflected in the magnitude of profits obtained by start-up business. Non-financial factors are measured from the attitudes of young entrepreneurs: self-efficacy and risk taking propensity. The business start-up community can have difficulty growing due to the lack of knowledge about measuring business success based on financial and non-financial factors. The purpose of this research is to help entrepreneurs measure the success of the start-up businesses they run. The object of the research is a start-up business that produces chips of banana at Mojowarno. This research uses a quantitative approach to process data and information research. The results of the research presents that financial and non-financial achievements affect simultaneously results.

  1. Start-up Success in a Small Island State: A Study among Entrepreneurs in Malta

    Directory of Open Access Journals (Sweden)

    Leonie Baldacchino

    2008-05-01

    Full Text Available This study focuses on entrepreneurs in the small island state of Malta and investigates whether starting up and running an enterprise is facilitated or hindered by being in a small island environment. Specifically it asks (1 whether being on a small island, on the periphery of a major market facilitates or hinders entrepreneurship and start-up success; (2 whether Malta’s cultural context and enterprise environment affect entrepreneurship and start-up success; (3 what the key success factors among Maltese start-ups are; and (4 how are creativity and innovation reflected in Maltese start-ups. Qualitative research among 13 start-ups is supported by telephone-based research among a sample of 90 respondents. Findings contribute to the pool of business expertise and context-specific information from small island states that is often missing from the international literature.

  2. Constraints on Liquidity for Start-ups: Entrepreneurial Motivation and the Effect of Government Funding Schemes (Japanese)

    OpenAIRE

    Yasuda, Takehiko

    2004-01-01

    This paper analyzes factors determining the scale of business start-ups using data sets from Japan. It shows that age, education, parents' occupation (company manager), business experience, and assets owned at the time of start-up have a significant positive impact on the scale of start-up funding, while independent start-up has a significantly negative impact. Furthermore, entrepreneurs motivated by a desire to contribute to society, a desire to make use of assets, the influence of others an...

  3. Effective and versatile software beamformation toolbox

    DEFF Research Database (Denmark)

    Kortbek, Jacob; Nikolov, Svetoslav; Jensen, Jørgen Arendt

    2007-01-01

    aperture to obtain a preferred constant F-number. An effective and versatile software toolbox for off-line beamformation designed to address all of these issues has been developed. It is capable of exploiting parallelization of computations on a Linux cluster and is written in C++ with a MATLAB (Math Works...... and stored in lookup-tables (LUT). Parametric beamforming can also be applied where calculations are done by demand, thus, reducing the storage demand dramatically. On a standard PC with a Pentium 4, 2.66 GHz processor running Linux the toolbox can beamform 100,000 points in lines of various directions in 20...

  4. 40 CFR 60.1205 - What happens to the operating requirements during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... requirements during periods of startup, shutdown, and malfunction? 60.1205 Section 60.1205 Protection of... requirements during periods of startup, shutdown, and malfunction? (a) The operating requirements of this subpart apply at all times except during periods of municipal waste combustion unit startup, shutdown, or...

  5. 40 CFR 62.15165 - What happens to the emission limits during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... during periods of startup, shutdown, and malfunction? 62.15165 Section 62.15165 Protection of Environment... emission limits during periods of startup, shutdown, and malfunction? (a) The emission limits of this subpart apply at all times except during periods of municipal waste combustion unit startup, shutdown, or...

  6. 40 CFR 60.1710 - What happens to the emission limits during periods of startup, shutdown, and malfunction?

    Science.gov (United States)

    2010-07-01

    ... during periods of startup, shutdown, and malfunction? 60.1710 Section 60.1710 Protection of Environment... during periods of startup, shutdown, and malfunction? (a) The emission limits of this subpart apply at all times except during periods of municipal waste combustion unit startup, shutdown, or malfunction...

  7. The relationship between start-ups, market mobility and employment growth : An empirical analysis for Dutch regions

    NARCIS (Netherlands)

    Koster, Sierdjan; van Stel, Andre

    Abstract Recent literature suggests two mechanisms through which the start-up of new firms contributes to economic development: the growth of start-ups and competition among incumbent firms induced by the start-ups. While existing studies derive the competition effect indirectly, this paper deploys

  8. Digital acceleration: from CERN to my startup and beyond

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    This seminar is organised in collaboration with CERN openlab. Our society has entered a disruption era, undertaking several consecutive digital transformations which will have an impact comparable to the industrial revolution. In order to keep up with the pace of innovation, it is necessary for society to digitally transform and thus embrace base technologies such as big data, deep learning and blockchain. From a real life example, this talk will analyse the journey made from CERN technology to a startup and conclude with ongoing innovative developments in a large French group specialised in digital trust, looking to address digital transformation. Find out more about David here: https://www.linkedin.com/in/manset Please join us for coffee at 10.30 Registration is only compulsory if you do not have a CERN access card.  

  9. Start-up of Rapsodie; Le demarrage de Rapsodie

    Energy Technology Data Exchange (ETDEWEB)

    Pontier, R. [Commissariat a l' Energie Atomique, 13 - Cadarache (France). Centre d' Etudes Nucleaires

    1967-07-01

    After giving a general description of Rapsodie this report presents the conditions in which the start-up occurred and in which the tests were carried out. A chronological account is given of the operations and of the main events which occurred. The modifications made to the reactor during this period are described and a synthesis of the results obtained is presented. (author) [French] Apres avoir donne de RAPSODIE une description tres generale, ce rapport expose le cadre dans lequel ont ete effectues le demarrage et les essais de l'installation, fait un historique du deroulement des operations et des principaux evenements qui sont intervenus, indique les modifications apportees au reacteur au cours de cette periode et presente une synthese des resultats obtenus. (auteur)

  10. A Start-Up Demonstration Test Involving Distant Failures

    Directory of Open Access Journals (Sweden)

    Amos E. Gera

    2013-01-01

    Full Text Available A new procedure for determining the acceptance or rejection of a system that undergoes a start-up demonstration set of tests is presented. It is a generalization of the recently introduced CSDF model (consecutive successes distant failures. According to the new total successes consecutive successes total failures distant failures (TSCSTFDF procedure, a unit is accepted when either a total number of successful tests or a specified number of consecutive successes are observed before a total number of failures or the occurrence of near failures which are too close to each other. The practical advantage of this new procedure is the significant reduction in the expected number of required tests together with improved second-order statistics (standard deviation.

  11. [Startup mechanism of moxibustion warming and dredging function].

    Science.gov (United States)

    Huang, Kaiyu; Liang, Shuang; Sun, Zheng; Zhang, Jianbin

    2017-09-12

    With "moxibustion" and "warm stimulation" as the keywords, the literature on moxibustion mechanism of warming and dredging from June 1st, 1995 to June 1st, 2016 was collected from PubMed, China National Knowledge Infrastructure (CNKI) and Wanfang database. The startup mechanism of moxibustion warming and dredging function was analyzed in terms of moxibustion warming stimulation. The results were found that moxibustion was based on local rising temperature of acupoint. It activated local specific receptors, heat sensitive immune cells, heat shock proteins and so on to start the warming and dredging function and produce various local effects. The warming stimulation signals as well as subsequent effects through nerve and body fluid pathways induced the effects of further specific target organs and body systems.

  12. Perempuan Pebisnis Startup di Indonesia dalam Perspektif Cybertopia

    Directory of Open Access Journals (Sweden)

    Rizka Kurnia Ayu

    2017-07-01

    Full Text Available This research aim to show the internet from cyberthopia perspective to discribe that the dogma in the society such as technologi as man extenions, It is not entirely true. To support this research,  ten indonesian statrtup women, with income hundreds of millions per month, were chosen as the main object in this research. Furthermore, the results of this study show that the Internet has blurred the gender boundary between femininity and masculinity. The statement of the existence of a man is no longer fully valid with the great success that has been achieved by these ten business startup women as economic agents of the family without releasing identity as a female figure.

  13. Foundations as Promoters of Life Science Start-ups.

    Science.gov (United States)

    Vonmont, Pascale

    2014-12-01

    Because private foundations have only modest financial resources compared to public and private-sector research funding, the only way in which foundations can play a key role is in the initial and risk financing of gap areas. This is generally in what is known as the 'valley of death', but even there an additional focus is needed. One promising field is the very early-stage support for high-risk but high-potential business cases in order to increase the number of start-ups, not only but very often in the field of life sciences. The pre-seed fund venture kick, an initiative by private foundations, is a good example of success. There is still a gap in the innovation chain in Switzerland from the first research results to becoming a successful life science company. However, for the first time promising solutions are on the way, and here too, foundations can play an important role.

  14. Careers at Biotech Start-Ups and in Entrepreneurship.

    Science.gov (United States)

    Froshauer, Susan

    2017-11-01

    The world of biotechnology "start-ups" and entrepreneurship offers exciting new avenues for driving state-of-the-art research using an arsenal of multidisciplinary skills, whether your role is as part of a team or as a leader. Although traditionally these positions may not be as secure as those offered by some of the larger companies, the small start-up culture provides opportunities for contributing at many levels to a wide range of responsibilities: from scientific discovery to delivery of proof of concept and intellectual property; from analysis of market opportunities and competitive intelligence to creation of time lines and business plans for a first product. Often, if you get in on the ground level, you get to validate your own concept, pitch to potential investors, argue value, build a team, engage advisors, and then, with funding in hand, launch an entirely new research and development (R&D) enterprise. Many of the skills and much of the experience gained while pursuing a graduate degree can be put to good use in these arenas as well. This path, however, is not for the faint of heart; it requires not only a strong scientific background and organizational skills, but also the ability to work well on a team, excellent communication skills, and persistence when faced with delays or disappointment. With increasing responsibilities in the small company come the requirements for aptitudes for leadership, strategic and financial planning, networking, negotiating, and managing both projects and personnel. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  15. Reactive Systems

    DEFF Research Database (Denmark)

    Aceto, Luca; Ingolfsdottir, Anna; Larsen, Kim Guldstrand

    A reactive system comprises networks of computing components, achieving their goals through interaction among themselves and their environment. Thus even relatively small systems may exhibit unexpectedly complex behaviours. As moreover reactive systems are often used in safety critical systems, t...... into account. The book has arisen from various courses taught in Denmark and Iceland and is designed to give students a broad introduction to the area, with exercises throughout......., the need for mathematically based formal methodology is increasingly important. There are many books that look at particular methodologies for such systems. This book offers a more balanced introduction for graduate students and describes the various approaches, their strengths and weaknesses, and when...... they are best used. Milner's CCS and its operational semantics are introduced, together with the notions of behavioural equivalences based on bisimulation techniques and with recursive extensions of Hennessy-Milner logic. In the second part of the book, the presented theories are extended to take timing issues...

  16. Versatile and Extensible, Continuous-Thrust Trajectory Optimization Tool Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop an innovative, versatile and extensible, continuous-thrust trajectory optimization tool for planetary mission design and optimization of...

  17. L'évaluation et le financement des start-up Internet

    OpenAIRE

    Ulrich Hege

    2001-01-01

    This paper discusses some phenomena in the corporate finance of internet start-ups that emerged during the “internet buble” between 1998-2000. The advent of nternet start-ups had a major impact on the investment flow and the operations of the venture capital industry in the US and in Europe. It is argued that some of these transformations could be explained by the potential for specific agency conflicts in the financing of internet start-ups. The paper then turns to a discussion of initial pu...

  18. Composition of regional conditions for start-up activity- evidence based on Swiss Mobilite Spatiale regions

    OpenAIRE

    Kronthaler, Franz; Becker, Katharina; Wagner, Kerstin

    2011-01-01

    Start-up activities are considered to be important for regional economic development and vary considerably between regions. As entrepreneurial activity in a region is strongly influenced by its regional conditions, we analyse the role of the conditions and their impact on start-up activities. The main objective of the paper is to identify the variables which are relevant for a typology of regions in terms of their start-up activity and to have a closer look on their region specific characteri...

  19. STARTUP IN SECONDARY EDUCATION AS A STIMULUS FOR THE LABOUR MARKET

    Directory of Open Access Journals (Sweden)

    Jerzy DYCHAŁA

    2015-07-01

    Full Text Available The aim of the article was to point out and characterize different problems connected with cooperation between sec-ondary schools and employers and benefits for local and national economy. The work discusses examples of cooperation among secondary schools, employers and higher education institutions. It also talks about introduction of practical en-trepreneurship to schools in form of startups. The article discusses forms of academic entrepreneurship i.e. entrepre-neurship incubator, spin off and spin out as continuation of secondary schools startups. It also characterizes startup in Great Britain.

  20. Lean Startup-metodologian hyödyntäminen kasvuyrityksessä

    OpenAIRE

    Louhi, Tapio

    2014-01-01

    Tämän työn tavoitteena oli tarjota kattava lähdemateriaali Lean Startup -metodologian mahdollisuuksista ja ohjeita sen työkalujen käytöstä. Työn tarkoituksena oli myös tutkia Lean Startup -ilmiötä ja sen syntyyn vaikuttaneita tekijöitä sekä opastaa lukijoita tuotekehityksessä ja Lean Startup -työkalujen käyttöönotossa. Metodologiaa tutkittiin lähdekirjallisuuden ja internet-tutkimuksen keinoin, sekä osallistumalla Nuori Yrittäjyys ry:n NY S...

  1. Lean Startup -menetelmien kehittäminen Collapick Company Oy:lle

    OpenAIRE

    Paakinaho, Henna

    2014-01-01

    Tässä opinnäytetyössä käsitellään Lean Startup –metodologiaa ja metodologian mukaisten mallien ja menetelmien rakentamista yrityksen tarpeiden mukaiseksi kokonaisuudeksi. Opinnäytetyössä esitellään Lean Startup –metodologian taustalla olevia menetelmiä sekä itse metodologiaa, sen ominaispiirteitä ja sille ominaisia toimintatapoja. Opinnäytetyön tarkoituksena oli rakentaa Lean Startup -metodologian mukaisia malleja ja menetelmiä hyödynnettäväksi toimeksiantajaryityksen liiketoiminnassa. O...

  2. Start-up problem with an induction machine and a permanent magnet gear

    DEFF Research Database (Denmark)

    Frandsen, Tommy; Berg, Nick Ilsø; Holm, Rasmus Koldborg

    2014-01-01

    This paper presents the preliminary work conducted to design a magnetic gear (MG) integrated with a fan and driven by an grid connected induction machine (IM). A start-up problem with a MG, which occurs due to a high oscillating torque and a high breakdown torque of the IM when starting up directly...... between the mass moment of inertia of the low and high speed side of the MG and their effects on the start-up problem have been examined. It is concluded by simulation that an increased mass moment of inertia on the high speed side of the MG can overcome the start-up problem, and this is verified...

  3. Collinear technology for a holographic versatile disk

    Science.gov (United States)

    Horimai, Hideyoshi; Tan, Xiaodi

    2006-02-01

    A novel reading and writing technology for a holographic versatile disk (HVD) system called collinear technology is developed. With this method a two-dimensional data page can be recorded as volumetric holograms generated by a reference beam and a signal beam that are bundled on the same axis and that are irradiated on the recording medium through a single objective lens. The multiplex recording and reconstruction process is demonstrated, and it is shown that the optical configuration and the dichroic medium disk structure are suitable for a compact system. With the HVD's special structure, the system can use a servo to focus, track, and locate the reading and writing addresses. A unique selectable-capacity recording format of a HVD and its standardization activity are also introduced. This method will enable us to construct a small HVD system with CD and DVD upper compatibilities.

  4. Californium-252: a remarkable versatile radioisotope

    Energy Technology Data Exchange (ETDEWEB)

    Osborne-Lee, I.W.; Alexander, C.W.

    1995-10-10

    A product of the nuclear age, Californium-252 ({sup 252}Cf) has found many applications in medicine, scientific research, industry, and nuclear science education. Californium-252 is unique as a neutron source in that it provides a highly concentrated flux and extremely reliable neutron spectrum from a very small assembly. During the past 40 years, {sup 252}Cf has been applied with great success to cancer therapy, neutron radiography of objects ranging from flowers to entire aircraft, startup sources for nuclear reactors, fission activation for quality analysis of all commercial nuclear fuel, and many other beneficial uses, some of which are now ready for further growth. Californium-252 is produced in the High Flux Isotope Reactor (HFIR) and processed in the Radiochemical Engineering Development Center (REDC), both of which are located at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The REDC/HFIR facility is virtually the sole supplier of {sup 252}Cf in the western world and is the major supplier worldwide. Extensive exploitation of this product was made possible through the {sup 252}Cf Market Evaluation Program, sponsored by the United States Department of Energy (DOE) [then the Atomic Energy Commission (AEC) and later the Energy Research and Development Administration (ERDA)]. This program included training series, demonstration centers, seminars, and a liberal loan policy for fabricated sources. The Market Evaluation Program was instituted, in part, to determine if large-quantity production capability was required at the Savannah River Laboratory (SRL). Because of the nature of the product and the means by which it is produced, {sup 252}Cf can be produced only in government-owned facilities. It is evident at this time that the Oak Ridge research facility can meet present and projected near-term requirements. The production, shipment, and sales history of {sup 252}Cf from ORNL is summarized herein.

  5. Mathematical modeling and analysis of heat pipe start-up from the frozen state

    Energy Technology Data Exchange (ETDEWEB)

    Jang, J.H.; Faghri, A. [Wright State Univ., Dayton, OH (United States); Chang, W.S.; Mahefkey, E.T. [Wright Research and Development Center, Wright-Patterson, OH (United States)

    1989-08-01

    The start-up process of a frozen heat pipe is described and a complete mathematical model for the start-up of the frozen heat pipe is developed based on the existing experimental data, which is simplified and solved numerically. The two-dimensional transient model for the wall and wick is coupled with the one-dimensional transient model for the vapor flow when vaporization and condensation occur at the interface. A parametric study is performed to examine the effect of the boundary specification at the surface of the outer wall on the successful start-up from the frozen state. For successful start-up, the boundary specification at the outer wall surface must melt the working substance in the condenser before dry-out takes place in the evaporator.

  6. Knowledge Management in Startups: Systematic Literature Review and Future Research Agenda

    National Research Council Canada - National Science Library

    Piera Centobelli; Roberto Cerchione; Emilio Esposito

    2017-01-01

    This paper conducts a systematic literature review on knowledge management (KM) in the context of startups in order to analyze the state of the art, identify research gaps and define a future research agenda...

  7. Cool-down and frozen start-up behavior of a grooved water heat pipe

    Science.gov (United States)

    Jang, Jong Hoon

    1990-01-01

    A grooved water heat pipe was tested to study its characteristics during the cool-down and start-up periods. The water heat pipe was cooled down from the ambient temperature to below the freezing temperature of water. During the cool-down, isothermal conditions were maintained at the evaporator and adiabatic sections until the working fluid was frozen. When water was frozen along the entire heat pipe, the heat pipe was rendered inactive. The start-up of the heat pipe from this state was studied under several different operating conditions. The results show the existence of large temperature gradients between the evaporator and the condenser, and the moving of the melting front of the working fluid along the heat pipe. Successful start-up was achieved for some test cases using partial gravity assist. The start-up behavior depended largely on the operating conditions.

  8. A single center analysis of factors influencing study start-up timeline in clinical trials.

    Science.gov (United States)

    Krafcik, Brianna M; Doros, Gheorghe; Malikova, Marina A

    2017-11-01

    Efficient start-up phase in clinical trials is crucial to execution. The goal was to determine factors contributing to delays. The start-up milestones were assessed for 38 studies and analyzed. Total start-up time was shorter for following studies: device trials, no outsourcing, fewer ancillary services used and in interventional versus observational designs. The use of a centralized Institutional Review Board (IRB) versus a local IRB reduced time to approval. Studies that never enrolled took longer on average to finalize their budget/contract, and obtain IRB than ones that did enroll. Different features of clinical trials can affect timeline of start-up process. An understanding of the impact of each feature allows for optimization.

  9. Mathematical modeling and analysis of heat pipe start-up from the frozen state

    Science.gov (United States)

    Jang, J. H.; Faghri, A.; Chang, W. S.; Mahefkey, E. T.

    1990-01-01

    The start-up process of a frozen heat pipe is described and a complete mathematical model for the start-up of the frozen heat pipe is developed based on the existing experimental data, which is simplified and solved numerically. The two-dimensional transient model for the wall and wick is coupled with the one-dimensional transient model for the vapor flow when vaporization and condensation occur at the interface. A parametric study is performed to examine the effect of the boundary specification at the surface of the outer wall on the successful start-up from the frozen state. For successful start-up, the boundary specification at the outer wall surface must melt the working substance in the condenser before dry-out takes place in the evaporator.

  10. Challenges in Bootstrapping a Start-Up Venture: Keenga Research Turning the Tables on Venture Capitalists

    National Research Council Canada - National Science Library

    Ensign, Prescott C; Woods, Anthony A

    2016-01-01

    ...). What makes this case unique is that Keenga Research was a lean start-up. Bootstrapping is a situation in which the entrepreneur chooses to fund the venture with his/her own personal resources...

  11. Legal Challenges and Pitfalls for Start-up Companies - 48 Common Questions and Answers.

    Science.gov (United States)

    Staehelin, Matthias

    2014-12-01

    Transforming a business idea into reality requires a legal implementation plan. The following 48 questions and answers address key issues that typically arise in start-up situations. Early planning can help avoid costly mistakes.

  12. Sensorless start-up of traction switched reluctance motors of the railway rolling stock

    Directory of Open Access Journals (Sweden)

    Maxim TCHAVYCHALOV

    2013-01-01

    Full Text Available The problem of SRM sensorless start is described. The new algorithm of traction switched reluctance motor sensorless start-up in a course is adduced. Results of physical modeling of the described method are given.

  13. Markkinointiviestintäsuunnitelman laadinta tulevalle matkailualan start-up yritykselle

    OpenAIRE

    Tammi, Karoliina

    2016-01-01

    Opinnäytetyön aiheena oli laatia tulevalle matkailualan start-up yritykselle markkinointiviestintäsuunnitelma. Start-up yrityksen liikeideana on tarjota extreme-painotteisia luontomatkailun ohjelmapalveluita Suomessa kansainvälisille nuorille aikuisille. Opinnäytetyön tarkoituksena oli antaa laaditulla markkinointiviestintäsuunnitelmalla yrittäjälle markkinoinnillista suuntaviivaa liiketoiminnan aloittamisvaiheessa. Tutkimuksen tavoitteena oli laatia yritykselle käytännönläheinen markkinointi...

  14. Experimental characterization of plasma start-up using ECRH in preparation of W7-X operation

    Directory of Open Access Journals (Sweden)

    Preynas M.

    2015-01-01

    Full Text Available The upcoming operation of Wendelstein 7-X (W7-X will be supported by an Electron Cyclotron Resonance Heating (ECRH system working at 140 GHz in second harmonic at the nominal magnetic field of 2.5T. Because the optimization of the plasma breakdown is crucial to ensure a successful plasma build-up, dedicated plasma start-up experiments were performed on three stellarator/heliotron devices: Heliotron J, LHD and WEGA. Start-up behavior and dependencies on ECRH injected power, neutral gas pressure and rotational transform were obtained in X2 heating. Plasma start-up delay time decreases with the increase in ECRH input power. However, this behavior saturates when low pre-fill neutral gas pressure conditions are met. Both the delay time and the electron density are an increasing function of the gas pressure. On Heliotron J and WEGA devices, the higher the rotational transform is, the faster the start-up and the higher the plasma density are. Analysis of the temporal evolution of the plasma start-up shows that plasma start-up on stellarators is a two-step process. In addition, off-axis heating experiments are characterized by a longer plasma start-up duration compared to on-axis heating discharges. Third harmonic in X-mode has been attempted on LHD for different neutral gas puffing settings but no plasma breakdown was achieved. This multi-machine study was useful to define ECRH start-up scenarios for W7-X.

  15. >venture>: Support for Early Stage Start-ups and Potential Entrepreneurs.

    Science.gov (United States)

    Kauz, Lukas

    2014-12-01

    >venture>, the leading Swiss-wide business plan competition, is an ideal partner for young start-ups and entrepreneurs. For the upcoming tenth anniversary edition the competition will receive an update. Building upon a successful base of the past nine editions and equipped with contemporary networking events and more know-how transferring seminars, >venture> will fit even better into the Swiss start-up ecosystem.

  16. Patterns in Student Perceptions of Start-Up and Conversion Small High Schools

    Science.gov (United States)

    Feldman, Jay; O'Dwyer, Anne

    2010-01-01

    Schools created as part of the small schools movement have been in operation for almost a decade, allowing identification of patterns in their growth. This study examines 4 years of survey data on 12 start-up and 13 conversion small high schools. Start-up small schools, almost all of which began with one grade level and grew by one grade per year,…

  17. On the Role of Entrepreneurial Experience for Start-up Financing: An Empirical Investigation for Germany

    OpenAIRE

    Metzger, Georg

    2007-01-01

    Entrepreneurs are often faced with problems regarding start-up financing. But compared to novice entrepreneurs, experienced entrepreneurs should have both more knowledge and better contacts, which should potentially reduce the occurrence of problems and affect finance composition. However, experience of business failure might result in additional effects. This analysis therefore investigates the effects of experience on several aspects of start-up financing. It is based on data from the KfW S...

  18. Phosphatidic acid, a versatile water-stress signal in roots

    Directory of Open Access Journals (Sweden)

    Fionn eMcLoughlin

    2013-12-01

    Full Text Available Adequate water supply is of utmost importance for growth and reproduction of plants. In order to cope with water deprivation, plants have to adapt their development and metabolism to ensure survival. To maximize water use efficiency, plants use a large array of signaling mediators such as hormones, protein kinases and phosphatases, Ca2+, reactive oxygen species and low abundant phospholipids that together form complex signaling cascades. Phosphatidic acid (PA is a signaling lipid that rapidly accumulates in response to a wide array of abiotic stress stimuli. PA formation provides the cell with spatial and transient information about the external environment by acting as a protein-docking site in cellular membranes. PA reportedly binds to a number of proteins that play a role during water limiting conditions, such as drought and salinity and has been shown to play an important role in maintaining root system architecture. Members of two osmotic stress-activated protein kinase families, sucrose non-fermenting 1-related protein kinase 2 (SnRK2 and mitogen activated protein kinases (MAPKs were recently shown bind PA and are also involved in the maintenance of root system architecture and salinity stress tolerance. In addition, PA regulates several proteins involved in abscisic acid (ABA-signaling. PA-dependent recruitment of glyceraldehyde-3-phosphate dehydrogenase (GAPDH under water limiting conditions indicates a role in regulating metabolic processes. Finally, a recent study also shows the PA recruits the clathrin heavy chain and a potassium channel subunit, hinting towards additional roles in cellular trafficking and potassium homeostasis. Taken together, the rapidly increasing number of proteins reported to interact with PA implies a broad role for this versatile signaling phospholipid in mediating salt and water stress responses.

  19. Innovative start-ups and young entrepreneurs: Definition of venturem capital and findings from Switzerland

    Directory of Open Access Journals (Sweden)

    Simon Zaby

    2017-02-01

    Full Text Available This paper aims to investigate success factors of innovative start-up firms from the perspective of young start-up managers. Which key factors did they experience before and since the foundation of their company? The experience from the quite young Swiss start-up scene pro-vides important insights to entrepreneurs and policy-makers in emerging countries that cur-rently face the necessity of building up a start-up environment. One part of the data has been collected by the author, the other part originates from the Swiss Venture Capital Database (total sample size: 306. The results show a significant role of venture capital financing for the success of innovative start-ups. Interestingly, this is to some extent because the start-ups see various additional benefits from venture capitalists involved in their firm. Thus, the findings shed new light on a proper definition of venture capital that should not solely focus on the flow of funds.

  20. Does Social Innovation Contribute to Sustainability? The Case of Italian Innovative Start-Ups

    Directory of Open Access Journals (Sweden)

    Michela Piccarozzi

    2017-12-01

    Full Text Available Start-ups, among other enterprises, play a major role in the development and/or commercialization of new technologies and the development of national economies, given that firms are the innovation locus for an entire society. In Italy, a recent regulatory intervention has focused on start-ups creating a framework where innovative start-ups are defined and regulated. Among innovative start-ups, those with a social vocation are of particular interest, since they are understudied in the literature. Indeed, the aim of this paper is twofold: to analyze the relationship between social innovation and sustainability in the latter businesses, and try to understand how sustainability could be fostered through them. Italian cases of innovative start-ups will be studied through content analysis applied to the Social Impact Assessment Document provided by firms. Results show that the Social Impact Assessment Document provided by innovative start-ups explicitly pays attention to social innovation and sustainability in different ways. However, the document does not show the link between social innovation and sustainability. Nonetheless, going through these documents, the link between social innovation and the three aspects of sustainability (economic, social and environmental clearly emerge and therefore could be better managed.

  1. SOP 98-5 brings uniformity to reporting start-up costs.

    Science.gov (United States)

    Luecke, R W; Meeting, D T

    1999-08-01

    The American Institute of Certified Public Accountants (AICPA) issued Statement of Position (SOP) No. 98-5, Reporting on the Costs of Start-Up Activities, in April 1998 to provide organizations with guidance on how to report start-up and organization costs. Because some companies were expensing start-up costs while other companies were capitalizing start-up costs with a variety of periods over which to amortize costs, it was difficult to compare companies' financial statements. SOP No. 98-5 will bring uniformity to the treatment of start-up and organization costs by dictating that these costs be expensed as incurred. AICPA's Accounting Standards Executive Committee adopted an intentionally broad definition of start-up costs to capture the vast majority of costs associated with starting up an organization. SOP No. 98-5 takes effect for financial statements for fiscal years beginning after December 15, 1998, but can be applied earlier for fiscal years for which financial statements have not been issued.

  2. Critical Incidents of Growth in Nordic eHealth Service Start-Ups

    Directory of Open Access Journals (Sweden)

    Martti Saarela

    2017-06-01

    Full Text Available Digitalisation can revolutionise healthcare delivery and provide new business opportunities for innovative start-ups. Start-up businesses in the healthcare service sector are a promising source of new employment and innovations. The start-up stage is the most critical period for the survival of a business, as decisions made during the early stages have a definitive influence on success. This study seeks to clarify the early development of eHealth service start-ups. To summarise the research problem, the authors ask the following question: What are the critical incidents related to the early development of eHealth service start-ups? The units of analysis in this study are 14 Nordic eHealth service start-ups located in Sweden and Finland. The Critical Incident Technique (CIT and semi-structured interviews were applied for data collection. The results are of interest to the public sector, which plays an essential role in healthcare as a service producer, but also as a creator of the business conditions of and opportunities for small businesses.

  3. Influence of start-up on PCDD/F emission of incinerators.

    Science.gov (United States)

    Wang, Lin-Chi; Hsi, Hsing-Cheng; Chang, Juu-En; Yang, Xing-Yi; Chang-Chien, Guo-Ping; Lee, Wei-Shan

    2007-04-01

    This study aims to evaluate the influence of start-up on polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) concentration in the stack flue gas of incinerators and its contributing PCDD/F emission. The PCDD/F emission of the first sample among three consecutive stack flue gas samples of five intermittent incinerators, which sampled at a stable combustion condition after start-up, is 2-3 times higher than the mean of the others. For verifying the PCDD/F characteristics of incinerators during start-up, one continuous MSWI was investigated for two years. The elevated PCDD/F emissions of the MSWI during start-up could reach 96.9 ng I-TEQN m(-3) and still maintained a high PCDD/F emission (40 times higher than the Taiwan emission limit) even 18 h after the injection of activated carbon, indicating the memory effect. Taking the MSWI for example, which consists of four incinerators, the estimated annual PCDD/F emission from normal operational conditions was 0.112 g I-TEQ. However, one start-up procedure can generate approximately 60% of the PCDD/F emissions for one whole year of normal operations. And the PCDD/F emission, which is the result of the start-ups of four incinerators, was at least two times larger than that of a whole year's normal operations, without consideration for the PCDD/F emission contributed by the long lasting memory effect.

  4. Pinon Pine power project nears start-up

    Energy Technology Data Exchange (ETDEWEB)

    Tatar, G.A. [Sierra Pacific Power Co., Reno, NV (United States); Gonzalez, M. [Foster Wheeler USA Corp., Clinton, NJ (United States); Mathur, G.K. [M.W. Kellogg Co., Houston, TX (United States)

    1997-12-31

    The IGCC facility being built by Sierra Pacific Power Company (SPPCo) at their Tracy Station in Nevada is one of three IGCC facilities being cost-shared by the US Department of Energy (DOE) under their Clean Coal Technology Program. The specific technology to be demonstrated in SPPCo`s Round Four Project, known as the Pinon Pine IGCC Project, includes the KRW air blown pressurized fluidized bed gasification process with hot gas cleanup coupled with a combined cycle facility based on a new GE 6FA gas turbine. Construction of the 100 MW IGCC facility began in February 1995 and the first firing of the gas turbine occurred as scheduled on August 15, 1996 with natural gas. Mechanical completion of the gasifier and other outstanding work is due in January 1997. Following the startup of the plant, the project will enter a 42 month operating and testing period during which low sulfur western and high sulfur eastern or midwestern coals will be processed.

  5. Electron-cyclotron plasma startup in the GDT experiment

    CERN Document Server

    Yakovlev, D V; Gospodchikov, E D; Solomakhin, A L; Savkin, V Ya; Bagryansky, P A

    2016-01-01

    The paper reports on a new plasma startup scenario in the Gas Dynamic Trap (GDT) magnetic mirror device. The primary 5 MW neutral beam injection (NBI) plasma heating system fires into a sufficiently dense plasma target ("seed plasma"), which is commonly supplied by an arc plasma generator. In the reported experiments, a different approach to seed plasma generation is explored. One of the channels of the electron cyclotron resonance (ECR) heating system is used to ionize the neutral gas and build up the density of plasma to a level suitable for NBI capture. After a short transition (about 1 ms) the discharge becomes essentially similar to a standard one initiated by the plasma gun. The paper presents the discharge scenario and experimental data on the seed plasma evolution during ECR heating, along with the dependencies on incident microwave power, magnetic configuration and pressure of a neutral gas. The characteristics of consequent high-power NBI discharge are studied and differences to the conventional sce...

  6. Start-up rhetoric in eight speeches of Barack Obama.

    Science.gov (United States)

    O'Connell, Daniel C; Kowal, Sabine; Sabin, Edward J; Lamia, John F; Dannevik, Margaret

    2010-10-01

    Our purpose in the following was to investigate the start-up rhetoric employed by U.S. President Barack Obama in his speeches. The initial 5 min from eight of his speeches from May to September of 2009 were selected for their variety of setting, audience, theme, and purpose. It was generally hypothesized that Barack Obama, widely recognized for the excellence of his rhetorical performance, would pursue both constant and variable strategies in his effort to establish contact with his audience. More specifically, it was hypothesized that the make-up of the audience--primarily native or non-native speakers of English--would be a prominent independent variable. A number of temporal and verbal measures were used as dependent variables. Variations were evident in mean length in syllables and duration in seconds of utterances (articulatory phrases), articulation rate in syllables per second of ontime, mean duration of silent pauses in seconds, and frequency of fillers, hesitations, colloquial words and phrases, introductory phrases, and 1st person singular pronominals. Results indicated that formality versus informality of the setting and presence or absence of a teleprompter were more prominent than native versus non-native audiences. Our analyses confirm Obama's skillfulness in challenging and variable settings and clearly detect orderliness and scientific generalizability in language use. The concept of orality/literacy provides a theoretical background and emphasizes dialogical interaction of audience and speaker.

  7. Acquisition Integration Models: How Large Companies Successfully Integrate Startups

    Directory of Open Access Journals (Sweden)

    Peter Carbone

    2011-10-01

    Full Text Available Mergers and acquisitions (M&A have been popular means for many companies to address the increasing pace and level of competition that they face. Large companies have pursued acquisitions to more quickly access technology, markets, and customers, and this approach has always been a viable exit strategy for startups. However, not all deals deliver the anticipated benefits, in large part due to poor integration of the acquired assets into the acquiring company. Integration can greatly impact the success of the acquisition and, indeed, the combined company’s overall market success. In this article, I explore the implementation of several integration models that have been put into place by a large company and extract principles that may assist negotiating parties with maximizing success. This perspective may also be of interest to smaller companies as they explore exit options while trying to ensure continued market success after acquisition. I assert that business success with acquisitions is dependent on an appropriate integration model, but that asset integration is not formulaic. Any integration effort must consider the specific market context and personnel involved.

  8. Rapid start-up and improvement of granulation in SBR.

    Science.gov (United States)

    Jalali, Sajjad; Shayegan, Jalal; Rezasoltani, Samira

    2015-01-01

    The aim of this study is to accelerate and improve aerobic granulation within a Sequencing Batch Reactor (SBR) by cationic polymer addition. To identify whether the polymer additive is capable of enhancing granule formation, two SBRs (R1 and R2, each 0.15 m in diameter and 2 m in height) are used by feeding synthetic wastewater. The cationic polymer with concentration of 30 to 2 ppm is added to R2, while no cationic polymer is added to R1. Results show that the cationic polymer addition causes faster granule formation and consequently shorter reactor start-up period. The polymer-amended reactor contains higher concentration of biomass with better settling ability (23% reduction in SVI15) and larger and denser granules (112% increase of granular diameter). In addition, the results demonstrate that the cationic polymer improve the sludge granulation process by 31% increase in Extracellular Polymer Substance(EPS) concentration, 7% increase in Specific Oxygen Uptake Rate(SOUR), 18% increase in hydrophobicity, and 17% reduction in effluent Mixed Liquor Suspended Solid(MLSS) concentration. Concludingly, it is found that using the cationic polymer to an aerobic granular system has the potential to enhance the sludge granulation process.

  9. Startup, Commissioning and Operation of Fenyi 100MW CFB Boiler

    Science.gov (United States)

    Wang, Zhiwei; Yu, Wugao; Bo, Shi

    The first 100MW CFB boiler, designed by the Thermal Power Research Institute and manufactured by Harbin Boiler Company Limited, has been successfully running in Jiangxi Fenyi Power Plant since 2003. Local high ash content anthracite and lean coal that are very difficult to burn out are used in the 100 MW CFB boiler. The results of the 100MW CFB boiler shows that the CFB boiler can run in 30% MCR and startup with two under bed burners, and the boiler efficiency higher than 88% can be got after the combustion modification test. The CFB boiler can be operated with full load and reaches design parameters. The emissions of NO, N2O and CO are less than 7Omg/m3, 30mg/m3, and 125mg/m3, respectively, and SO2 less than 400mg/m3 after limestone injection. The bottom ash temperature from bed ash coolers is less than 120°C after its modification. Coal blockage at the coal storage silo is the main problem influencing the CFB boiler continuous operation. The running experiences for 5 years proved that the CFB boiler performance is successful, and the results were applied in 210 MW and 330 MW CFB Boiler design of Fenyi Power Plant.

  10. International Space Station Lithium-Ion Battery Start-Up

    Science.gov (United States)

    Dalton, Penni J.; North, Tim; Bowens, Ebony; Balcer, Sonia

    2017-01-01

    International Space Station Lithium-Ion Battery Start-Up.The International Space Station (ISS) primary Electric Power System (EPS) was originally designed to use Nickel-Hydrogen (Ni-H2) batteries to store electrical energy. The electricity for the space station is generated by its solar arrays, which charge batteries during insolation for subsequent discharge during eclipse. The Ni-H2 batteries are designed to operate at a 35 depth of discharge (DOD) maximum during normal operation in a Low Earth Orbit. As the oldest of the 48 Ni-H2 battery Orbital Replacement Units (ORUs) has been cycling since September 2006, these batteries are now approaching their end of useful life. In 2010, the ISS Program began the development of Lithium-Ion (Li-ion) batteries to replace the Ni-H2 batteries and concurrently funded a Li-Ion ORU and cell life testing project. The first set of 6 Li-ion battery replacements were launched in December 2016 and deployed in January 2017. This paper will discuss the Li-ion battery on-orbit start-up and the status of the Li-Ion cell and ORU life cycle testing.

  11. Pilot-scale hydrogen fermentation system start-up performance

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Chiu-Yue; Lay, Chyi-How [Department of Environmental Engineering and Science, Feng Chia University, Taichung 40724 (China); Wu, Shu-Yii; Lin, Ping-Jei; Chang, Alex C. [Department of Chemical Engineering, Feng Chia University, Taichung 40724 (China); Chang, Jo-Shu [Department of Chemical Engineering, National Cheng Kung University, Taichung 40724 (China); Hung, Chun-Hsiung; Cheng, Chin-Hung [Department of Environmental Engineering, National Chung-Hsing University, Taichung 402 (China); Lee, Kuo-Shing [Department of Safety Health and Environmental Engineering, Central Taiwan University of Science and Technology (China); Chang, Feng-Yuan; Chu, Chen-Yeon [Research Center for Energy and Resources, Feng Chia University, Taichung 40724 (China)

    2010-12-15

    A high-rate hydrogen production process able to produce H{sub 2} at a maximum rate of 15 L/L/h was successfully developed by the Feng Chia University (FCU) biohydrogen research team. This highly efficient hydrogen fermentation system includes a 400 L pilot-scale system constructed for determining scale-up operation parameters for commercializing the bioH{sub 2} production technology. The pilot-scale system is composed of a feedstock tank, mixing system, fermentor, gas/liquid separator and automatic control system. The fermentor is fed with sucrose (20 g COD/L) and operated at 35 C. A batch strategy is used for system start-up. The fermentor was first operated in a batch mode for two days and then switched to a continuous-feeding mode (HRT 12 h) for one month. During the continuous operation, pH notably affected H{sub 2} production efficiency and bacterial community. For the first 14-day operation, the H{sub 2} production rate increased from 0.017 to 0.256 L/L/h with a pH variation from 5.0 to 7.0. The DGGE results indicate the presence of two Clostridium species (namely, Clostridium butyricum and Clostridium pasteurianum) in the fermenter. Stable hydrogen production rate was obtained at pH 5.5-6.0 when C. pasteurianum became dominant in the mixed culture. (author)

  12. Control Valve Trajectories for SOFC Hybrid System Startup

    Energy Technology Data Exchange (ETDEWEB)

    Gorrell, Megan; Banta, Larry; Rosen, William; Restrepo, Bernardo; Tucker, David

    2012-07-01

    Control and management of cathode airflow in a solid oxide fuel cell gas turbine hybrid power system was analyzed using the Hybrid Performance (HyPer) hardware simulation at the National Energy Technology (NETL), U.S. Department of Energy. This work delves into previously unexplored operating practices for HyPer, via simultaneous manipulation of bypass valves and the electric load on the generator. The work is preparatory to the development of a Multi-Input, Multi-Output (MIMO) controller for HyPer. A factorial design of experiments was conducted to acquire data for 81 different combinations of the manipulated variables, which consisted of three air flow control valves and the electric load on the turbine generator. From this data the response surface for the cathode airflow with respect to bypass valve positions was analyzed. Of particular interest is the control of airflow through the cathode during system startup and during large load swings. This paper presents an algorithm for controlling air mass flow through the cathode based on a modification of the steepest ascent method.

  13. Electron cyclotron plasma startup in the GDT experiment

    Science.gov (United States)

    Yakovlev, D. V.; Shalashov, A. G.; Gospodchikov, E. D.; Solomakhin, A. L.; Savkin, V. Ya.; Bagryansky, P. A.

    2017-01-01

    We report on a new plasma startup scenario in the gas dynamic trap (GDT) magnetic mirror device. The primary 5 MW neutral beam injection (NBI) plasma heating system fires into a sufficiently dense plasma target (‘seed plasma’), which is commonly supplied by an arc plasma generator. In the reported experiments, a different approach to seed plasma generation is explored. One of the channels of the electron cyclotron resonance (ECR) heating system is used to ionize the neutral gas and build up the density of plasma to a level suitable for NBI capture. After a short transition of approximately 1 ms the discharge becomes essentially similar to a standard one initiated by the plasma gun. This paper presents the discharge scenario and experimental data on the seed plasma evolution during ECRH, along with the dependencies on incident microwave power, magnetic configuration and pressure of a neutral gas. The characteristics of the consequent high-power NBI discharge are studied and differences from the conventional scenario are discussed. A theoretical model describing the ECR breakdown and the seed plasma accumulation in a large-scale mirror trap is developed on the basis of the GDT experiment.

  14. Advancing Non-Solenoidal Startup on the Pegasus ST

    Science.gov (United States)

    Reusch, J. A.; Barr, J. L.; Bodner, G. M.; Bongard, M. W.; Burke, M. G.; Fonck, R. J.; Pachicano, J. L.; Perry, J. M.; Richner, N. J.; Rodriguez Sanchez, C.; Schlossberg, D. J.

    2016-10-01

    The Pegasus experiment utilizes compact, edge-localized current sources (Ainj 2 - 4 cm2, Iinj 10 kA, Vinj 1 kV) for non-solenoidal local helicity injection (LHI) startup. Recent campaigns are comparing two injector geometries that vary the differing relative contributions of DC helicity input and non-solenoidal inductive voltages. A predictive 0-D model that treats the plasma as a resistive element with time-varying inductance and enforces Ip limits from Taylor relaxation was tested with inward growth of the plasma current channel using injectors on the outboard midplane. Strong inductive drive arises from plasma shape evolution and poloidal field (PF) induction. A major unknown in the model is the resistive dissipation, and hence the electron confinement. Te (R) profile measurements in LHI show centrally-peaked Te > 100 eV while the plasma is coupled to the injectors, suggesting LHI confinement is not strongly stochastic. A second campaign utilizes new injectors in the lower divertor region. This geometry trades subtler relaxation field programming and reduced PF induction for higher HI rates. Present efforts are developing relaxation methods at high BT, with relaxation at BT , inj > 0.15 T achieved to date via higher Iinj and PF manipulation. Conceptual design studies of coaxial helicity injection (CHI) and ECH heating systems for Pegasus have been initiated to explore direct comparison of LHI to CHI with and without ECH assist. Supported by US DOE Grants DE-FG02-96ER54375, DE-SC0006928.

  15. Conceptual design of the IFMIF Start-Up monitoring module

    Energy Technology Data Exchange (ETDEWEB)

    Gouat, Philippe, E-mail: philippe.gouat@sckcen.be [SCK-CEN – The Belgian Nuclear Research Centre, Boeretang 200, B-2400 Mol (Belgium); Leysen, Willem; Goussarov, Andrei; Galledou, Papa Sally [SCK-CEN – The Belgian Nuclear Research Centre, Boeretang 200, B-2400 Mol (Belgium); Rapisarda, David; Mota, Fernando; Garcia, Angela [CIEMAT – Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, Avda. Complutense 40, 28040 Madrid (Spain)

    2013-10-15

    Highlights: ► IFMIF test module conceptual design. ► IFMIF test module foreseen instrumentation. ► Cerenkov photon flux monitor. -- Abstract: The preliminary engineering design of the test facilities, including the various test modules to be used in the IFMIF plant is a part of the IFMIF/EVEDA (Engineering Validation and Engineering Design Activities) project from the Broader Approach to fusion. One presents the current status of the conceptual development of the IFMIF Start-Up Monitoring Module, a dedicated device used in the IFMIF test cell during the commissioning phase of the installation, in order to completely characterise the irradiation conditions behind the target on which the beam of deuterons will be focused. This STUMM embarks a lot of instrumentation to precisely characterise the neutron field, the nuclear heating and the temperatures in the test cell. One briefly describes the measuring instruments (including a specific radiation flux monitor under development), the possible layouts and the possible positioning. One also defines which types of measurements are expected by this especially dedicated commissioning module.

  16. Development of versatile multiaperture negative ion sources

    Science.gov (United States)

    Cavenago, M.; Serianni, G.; Antoni, V.; Bigi, M.; De Muri, M.; Pasqualotto, R.; Recchia, M.; Veltri, P.; Agostinetti, P.; Barbisan, M.; Baseggio, L.; Cervaro, V.; Cazzador, M.; Degli Agostini, F.; Franchin, L.; Kulevoy, T.; Laterza, B.; Mimo, A.; Minarello, A.; Petrenko, S.; Ravarotto, D.; Rossetto, F.; Sattin, M.; Zaniol, B.; Zucchetti, S.

    2015-04-01

    Enhancement of negative ion sources for production of large ion beams is a very active research field nowadays, driven from demand of plasma heating in nuclear fusion devices and accelerator applications. As a versatile test bench, the ion source NIO1 (Negative Ion Optimization 1) is being commissioned by Consorzio RFX and INFN. The nominal beam current of 135 mA at -60 kV is divided into 9 beamlets, with multiaperture extraction electrodes. The plasma is sustained by a 2 MHz radiofrequency power supply, with a standard matching box. A High Voltage Deck (HVD) placed inside the lead shielding surrounding NIO1 contains the radiofrequency generator, the gas control, electronics and power supplies for the ion source. An autonomous closed circuit water cooling system was installed for the whole system, with a branch towards the HVD, using carefully optimized helical tubing. Insulation transformer is installed in a nearby box. Tests of several magnetic configurations can be performed. Status of experiments, measured spectra and plasma luminosity are described. Upgrades of magnetic filter, beam calorimeter and extraction grid and related theoretical issues are reviewed.

  17. Versatility of hydrocarbon production in cyanobacteria.

    Science.gov (United States)

    Xie, Min; Wang, Weihua; Zhang, Weiwen; Chen, Lei; Lu, Xuefeng

    2017-02-01

    Cyanobacteria are photosynthetic microorganisms using solar energy, H2O, and CO2 as the primary inputs. Compared to plants and eukaryotic microalgae, cyanobacteria are easier to be genetically engineered and possess higher growth rate. Extensive genomic information and well-established genetic platform make cyanobacteria good candidates to build efficient biosynthetic pathways for biofuels and chemicals by genetic engineering. Hydrocarbons are a family of compounds consisting entirely of hydrogen and carbon. Structural diversity of the hydrocarbon family is enabled by variation in chain length, degree of saturation, and rearrangements of the carbon skeleton. The diversified hydrocarbons can be used as valuable chemicals in the field of food, fuels, pharmaceuticals, nutrition, and cosmetics. Hydrocarbon biosynthesis is ubiquitous in bacteria, yeasts, fungi, plants, and insects. A wide variety of pathways for the hydrocarbon biosynthesis have been identified in recent years. Cyanobacteria may be superior chassis for hydrocabon production in a photosynthetic manner. A diversity of hydrocarbons including ethylene, alkanes, alkenes, and terpenes can be produced by cyanobacteria. Metabolic engineering and synthetic biology strategies can be employed to improve hydrocarbon production in cyanobacteria. This review mainly summarizes versatility and perspectives of hydrocarbon production in cyanobacteria.

  18. Plasmonic Biofoam: A Versatile Optically Active Material.

    Science.gov (United States)

    Tian, Limei; Luan, Jingyi; Liu, Keng-Ku; Jiang, Qisheng; Tadepalli, Sirimuvva; Gupta, Maneesh K; Naik, Rajesh R; Singamaneni, Srikanth

    2016-01-13

    Owing to their ability to confine and manipulate light at the nanoscale, plasmonic nanostructures are highly attractive for a broad range of applications. While tremendous progress has been made in the synthesis of size- and shape-controlled plasmonic nanostructures, their integration with other materials and application in solid-state is primarily through their assembly on rigid two-dimensional (2D) substrates, which limits the plasmonically active space to a few nanometers above the substrate. In this work, we demonstrate a simple method to create plasmonically active three-dimensional biofoams by integrating plasmonic nanostructures with highly porous biomaterial aerogels. We demonstrate that plasmonic biofoam is a versatile optically active platform that can be harnessed for numerous applications including (i) ultrasensitive chemical detection using surface-enhanced Raman scattering; (ii) highly efficient energy harvesting and steam generation through plasmonic photothermal heating; and (iii) optical control of enzymatic activity by triggered release of biomolecules encapsulated within the aerogel. Our results demonstrate that 3D plasmonic biofoam exhibits significantly higher sensing, photothermal, and loading efficiency compared to conventional 2D counterparts. The design principles and processing methodology of plasmonic aerogels demonstrated here can be broadly applied in the fabrication of other functional foams.

  19. Start-up costs of thermal power plants in markets with increasing shares of variable renewable generation

    Science.gov (United States)

    Schill, Wolf-Peter; Pahle, Michael; Gambardella, Christian

    2017-06-01

    The emerging literature on power markets with high shares of variable renewable energy sources suggests that the costs of more frequent start-ups of thermal power plants may become an increasing concern. Here we investigate how this develops in Germany, where the share of variable renewables is expected to grow from 14% in 2013 to 34% in 2030. We show that the overall number of start-ups grows by 81%, while respective costs increase by 119% in this period. Related to variable renewables' production, start-up costs increase by a mere €0.70 per additional megawatt hour. While the expansion of variable renewables alone would increase start-up costs, more flexible biomass power plants and additional power storage have counteracting effects. Yet changes in reserve provision and fuel prices increase start-up costs again. The relevance of start-up costs may grow further under continued renewable expansion, but could be mitigated by increasing system flexibility.

  20. Startup of new plants and process technology in the process industries:organizing for an extreme event

    OpenAIRE

    Lager, T. (Thomas)

    2012-01-01

    In the startup of new process plants or in the introduction of new process technology, even minor installation work can cause plant downtime. On the other hand, the increased income from compressing time schedules for the introduction of new process technology or launching of associated new products on the market surely offers an incentive for securing efficient startups, which is the purpose of this study. A review of publications in the area of startup of process plants shows that organizat...

  1. Comparing the Entrepreneurial Ecosystems for Technology Startups in Bangalore and Hyderabad, India

    Directory of Open Access Journals (Sweden)

    M H Bala Subrahmanya

    2017-07-01

    Full Text Available Technology startups are gaining increasing attention from policy makers the world over because they are seen as a means of encouraging innovations, spurring the development of new products and services, and generating employment. Technology startups tend to thrive when inserted in a conducive entrepreneurial ecosystem. Therefore, ecosystem promotion is being given increasing policy support. However, the emergence and structure of entrepreneurial ecosystems for technology startups have hardly been traced and examined in detail. In India, Bangalore occupies a unique position in the startup world, and Hyderabad is fast emerging as one of the promising startup hubs in the country. Given this background, we set out to explore and examine the structure, evolution, and growth of ecosystems for technology startups in the context of Bangalore and Hyderabad. Both the ecosystems emerged due to the initial foundation laid in the form of government–industry–academia triple helix and their interactions leading to the emergence of a modern industrial cluster followed by an information technology and biotechnology cluster, which then led to R&D cluster serving both the cities. These three clusters together, gradually and steadily, facilitated an entrepreneurial ecosystem for technology startups to emerge. The ecosystem operates within the triple helix model and has a nucleus with two outer layers: i an inner layer of primary (indispensable factors and ii an outer layer of supplementary (secondary factors. Through the analysis of the experiences of Bangalore and Hyderabad and their ecosystem evolution, its structure, and components, we derive key lessons for others within and beyond India.

  2. Developing competitive advantage through startups and venture capital in emerging markets: A view from Israel.

    Directory of Open Access Journals (Sweden)

    Alexander Maune

    2017-06-01

    Full Text Available This article presents an examination of the emergence and co-evolution of startups and venture capital that led to the transformation of Israel into a Start-Up and Innovation Nation since its inception in 1948. Throughout, the co-evolution of startups and venture capital was considered a critical linkage between venture capital emergence and startup intensive cluster. The article also examined the three phased evolutionary model of 1969 to 2000. A discursive approach of related relevant literature was used. The study found out that the co-evolution of startups and venture capital, policy targeting and a network of a number of other factors as will be discussed in the three phased evolutionary model were critical to the emergence and change of the Israeli high-technology industry into a high-technology startup intensive industry. Israel has become the second largest world market for venture capital with more than 240 venture capitals since 1992. Israel has also become the lead in research and development attracting more than 270 multinational companies with more than 250 establishing research centers and employing over 108 000 in the country. The study also found that Israel leads other nations in per capita startups, engineers, scientists and technicians. This article will be critical for policy formulation and implementation especially in Emerging Markets. This article may lead to a shift in strategy in many emerging countries. This article will also help expand the academic knowledge by filling the existing gaps within the body of knowledge. Therefore, the article has academic, economic and policy value.

  3. NCI Start-Up Program 2.0: An Evaluation Option License Program | NCI Technology Transfer Center | TTC

    Science.gov (United States)

    NCI's Start-Up Evaluation Option License minimizes barriers to entry faced by start-up companies that seek to license NIH technologies. The license encourages and supports the commercial development of early-stage technologies developed in the NIH Intramural Research Program. While the NIH has been quite flexible in structuring licenses for the benefit of start-up companies, one of the goals of the NIH Start-up License program is to further reduce the time and capital to negotiate and finalize an exclusive license agreement. | [google6f4cd5334ac394ab.html

  4. Versatile transmission ellipsometry to study linear ferrofluid magneto-optics

    NARCIS (Netherlands)

    Kooij, Ernst S.; Galca, A.C.; Poelsema, Bene

    2006-01-01

    Linear birefringence and dichroism of magnetite ferrofluids are studied simultaneously using spectroscopic ellipsometry in transmission mode. It is shown that this versatile technique enables highly accurate characterisation of magneto-optical phenomena. Magnetic field-dependent linear birefringence

  5. A versatile hardware platform for brain computer interfaces.

    Science.gov (United States)

    Garcia, Pablo A; Haberman, Marcelo; Spinelli, Enrique M

    2010-01-01

    This article presents the development of a versatile hardware platform for brain computer interfaces (BCI). The aim of this work is to produce a small, autonomous and configurable BCI platform adaptable to the user's needs.

  6. Electrospun nanofibers as versatile interfaces for efficient gene delivery

    National Research Council Canada - National Science Library

    Lee, Slgirim; Jin, Gyuhyung; Jang, Jae-Hyung

    2014-01-01

    The integration of gene delivery technologies with electrospun nanofibers is a versatile strategy to increase the potential of gene therapy as a key platform technology that can be readily utilized...

  7. Intentions to Apply as Internship Students on Digital Start-Up Companies in Jakarta

    Directory of Open Access Journals (Sweden)

    Liza Agustina Maureen Nelloh

    2017-11-01

    Full Text Available Human capital plays an important role in explaining organizational performance and survival, not only for well-established firms but also for digital startup companies. However no previous human resource literature, especially on employers’ brand, investigates the internship program in the startup digital firms. Our pre-test shows that students are less attracted to apply to startup digital companies. Consequently, this study aims to test students’ intention to be on an internship in startup digital companies with its several antecedents (organizational attractiveness, job meaning, organizational attributes, and institutional image. My purposive sampling generates 101 business and management students in Jakarta as my sample. I run Partial Least Square (PLS to test my hypothesis. The results indicate that organizational attributes do not affect intention to be on an internship and other hypothesis tests exhibit positive results. Further, the findings also show that organizational attributes do not exhibit mediating effect. Overall, the results suggest that digital startup companies cooperate and collaborate with universities, especially business and management departments in research and student projects in order to attract the best students to be on internship on these companies that eventually will improve their performance. Abstrak Sumber Daya Manusia memegang peran penting dalam ketahanan dan peningkatan kinerja perusahaan baik berskala besar ataupun berskala startup digital. Akan tetapi, penelitian sebelumnya mengenai sumber daya manusia khususnya merek perekrut yang menguji secara khusus pada program magang yang banyak dilakukan oleh jurusan bisnis dan manajemen atau sejenisnya masih jarang dilakukan. Kemudian, hasil prates menunjukkan rendahnya ketertarikan dan keinginan mahasiswa untuk melamar di perusahaan startup digital. Oleh karena itu, penelitian ini bertujuan untuk menguji intensi melamar calon mahasiswa magang di perusahaan

  8. Organising a conference? Think about what you can do for start-ups!

    CERN Multimedia

    David Mazur

    2016-01-01

    ICTR-PHE 2016 welcomed 16 exhibitors and sponsors as part of its industrial exhibition. If you have ever (co-)organised a large scientific conference, you almost certainly have your own list of major industrial actors who could be interested in becoming exhibitors or sponsors.   The six start-ups present at ICTR-PHE 2016 – Oncoradiomics, Colnec Health, Dixit Solutions, e-Learning4Health, I-See Computing and SmART Scientific Solutions (not pictured). (Image: Salvatore Fiore) ICTR-PHE has shown that scientific conferences can have a catalysing role in transforming young start-ups and spin-off companies into the key industrial players of tomorrow. A special start-up corner was provided in the industrial exhibition, where small stands were made available for a modest fee to start-ups and spin-off companies in fields relevant to the conference theme, together with a 5-minute timeslot for a pitch to the audience. Six start-ups, from the Netherlands, Italy and France...

  9. Effect of zero-valent iron and trivalent iron on UASB rapid start-up.

    Science.gov (United States)

    Wang, Jie; Fang, Hongyan; Jia, Hui; Yang, Guang; Gao, Fei; Liu, Wenbin

    2018-01-01

    In order to realize the rapid start-up of upflow anaerobic sludge blanket (UASB) reactor, the iron ion in different valence state was added to UASB. The results indicated that the start-up time of R3 (FeCl 3 ) was 48 h faster than that of R2 (zero-valent iron (ZVI)). It was because the FeCl 3 could rapidly promote granulation of sludge as a flocculant. However, ZVI released Fe 2+ through corrosion slowly, and then the Fe 2+ increased start-up speed by enhancing enzyme activity and enriching methanogens. In addition, the ZVI and FeCl 3 could promote hydrolysis acidification and strengthen the decomposition of long-chain fatty acids. The detection of iron ions showed that iron ions mainly existed in the sludge. Because the high concentration of Fe 2+ could inhibit anaerobic bacteria activity, excess Fe 3+ could be changed into iron hydroxide precipitation to hinder the mass transfer process of anaerobic bacteria under the alkaline condition. The FeCl 3 was suitable to be added at the initial stage of UASB start-up, and the ZVI was more fitted to be used in the middle stage of reactor start-up to improve the redox ability.

  10. Historical aspects of arising and features of activity of startup companies: accounting and economic aspects

    Directory of Open Access Journals (Sweden)

    S.F. Legenchuk

    2016-07-01

    Full Text Available The history of arising and development of the concept of «startup company» have been studied and the importance of their activities have been determined. Using the largest startups (Amazon, Google, Salesforce, VMware, Facebook, Twitter, Groupon, Zynga and Аpple the main components of their activity have been determined. Because of the lack of the scientific literature that directly investigated this topic the approaches of different authors from electronic sources have been systematized and the most used of them have been analyzed. The own vision of the definition of «startup company» and its key features have been formulated as a result of the research. The place of a startup company in the system of economic categories such as an economic activity, results of company activities, accounting, analysis and risks have been determined. The impact of the consequences of risks (positive and negative of economic activity on the future of companies have been considered. The value of accounting and analysis for the economic activity of startup companies have been evaluated.

  11. Numerical Investigation of Transient Flow in a Prototype Centrifugal Pump during Startup Period

    Science.gov (United States)

    Zhang, Yu-Liang; Zhu, Zu-Chao; Dou, Hua-Shu; Cui, Bao-Ling; Li, Yi; Zhou, Zhao-Zhong

    2017-05-01

    Transient performance of pumps during transient operating periods, such as startup and stopping, has drawn more and more attentions recently due to the growing engineering needs. During the startup period of a pump, the performance parameters such as the flow rate and head would vary significantly in a broad range. Therefore, it is very difficult to accurately specify the unsteady boundary conditions for a pump alone to solve the transient flow in the absence of experimental results. The closed-loop pipe system including a centrifugal pump is built to accomplish the self-coupling calculation. The three-dimensional unsteady incompressible viscous flow inside the passage of the pump during startup period is numerically simulated using the dynamic mesh method. Simulation results show that there are tiny fluctuations in the flow rate even under stable operating conditions and this can be attributed to influence of the rotor-stator interaction. At the very beginning of the startup, the rising speed of the flow rate is lower than that of the rotational speed. It is also found that it is not suitable to predict the transient performance of pumps using the calculation method of quasi-steady flow, especially at the earlier period of the startup.

  12. Preliminary investigation of flow dynamics during the start-up of a bulb turbine model

    Science.gov (United States)

    Coulaud, M.; Fraser, R.; Lemay, J.; Duquesne, P.; Aeschlimann, V.; Deschênes, C.

    2016-11-01

    Nowadays, the electricity network undergoes more perturbations due to the market demand. Additionally, an increase of the production from alternative resources such as wind or solar also induces important variations on the grid. Hydraulic power plants are used to respond quickly to these variations to stabilize the network. Hydraulic turbines have to face more frequent start-up and stop sequences that might shorten significantly their life time. In this context, an experimental analysis of start-up sequences has been conducted on the bulb turbine model of the BulbT project at the Hydraulic Machines Laboratory (LAMH) of Laval University. Maintaining a constant head, guide vanes are opened from 0 ° to 30 °. Three guide vanes opening speed have been chosen from 5 °/s to 20 °/s. Several repetitions were done for each guide vanes opening speed. During these sequences, synchronous time resolved measurements have been performed. Pressure signals were recorded at the runner inlet and outlet and along the draft tube. Also, 25 pressure measurements and strain measurements were obtained on the runner blades. Time resolved particle image velocimetry were used to evaluate flowrate during start-up for some repetitions. Torque fluctuations at shaft were also monitored. This paper presents the experimental set-up and start-up conditions chosen to simulate a prototype start-up. Transient flowrate methodology is explained and validation measurements are detailed. The preliminary results of global performances and runner pressure measurements are presented.

  13. Model based analysis of the time scales associated to pump start-ups

    Energy Technology Data Exchange (ETDEWEB)

    Dazin, Antoine, E-mail: antoine.dazin@lille.ensam.fr [Arts et métiers ParisTech/LML Laboratory UMR CNRS 8107, 8 bld Louis XIV, 59046 Lille cedex (France); Caignaert, Guy [Arts et métiers ParisTech/LML Laboratory UMR CNRS 8107, 8 bld Louis XIV, 59046 Lille cedex (France); Dauphin-Tanguy, Geneviève, E-mail: genevieve.dauphin-tanguy@ec-lille.fr [Univ Lille Nord de France, Ecole Centrale de Lille/CRISTAL UMR CNRS 9189, BP 48, 59651, Villeneuve d’Ascq cedex F 59000 (France)

    2015-11-15

    Highlights: • A dynamic model of a hydraulic system has been built. • Three periods in a pump start-up have been identified. • The time scales of each period have been estimated. • The parameters affecting the rapidity of a pump start-up have been explored. - Abstract: The paper refers to a non dimensional analysis of the behaviour of a hydraulic system during pump fast start-ups. The system is composed of a radial flow pump and its suction and delivery pipes. It is modelled using the bond graph methodology. The prediction of the model is validated by comparison to experimental results. An analysis of the time evolution of the terms acting on the total pump pressure is proposed. It allows for a decomposition of the start-up into three consecutive periods. The time scales associated with these periods are estimated. The effects of parameters (angular acceleration, final rotation speed, pipe length and resistance) affecting the start-up rapidity are then explored.

  14. Advanced automation concepts applied to Experimental Breeder Reactor-II startup

    Energy Technology Data Exchange (ETDEWEB)

    Berkan, R.C.; Upadhyaya, B.R.; Bywater, R.L. (Tennessee Univ., Knoxville, TN (United States). Dept. of Nuclear Engineering); Kisner, R.A. (Oak Ridge National Lab., TN (United States))

    1991-08-01

    The major objective of this work is to demonstrate through simulations that advanced liquid-metal reactor plants can be operated from low power by computer control. Development of an automatic control system with this objective will help resolve specific issues and provide proof through demonstration that automatic control for plant startup is feasible. This paper presents an advanced control system design for startup of the Experimental Breeder Reactor-2 (EBR-2) located at Idaho Falls, Idaho. The design incorporates recent methods in nonlinear control with advanced diagnostics techniques such as neural networks to form an integrated architecture. The preliminary evaluations are obtained in a simulated environment by a low-order, valid nonlinear model. Within the framework of phase 1 research, the design includes an inverse dynamics controller, a fuzzy controller, and an artificial neural network controller. These three nonlinear control modules are designed to follow the EBR-2 startup trajectories in a multi-input/output regime. They are coordinated by a supervisory routine to yield a fault-tolerant, parallel operation. The control system operates in three modes: manual, semiautomatic, and fully automatic control. The simulation results of the EBR-2 startup transients proved the effectiveness of the advanced concepts. The work presented in this paper is a preliminary feasibility analysis and does not constitute a final design of an automated startup control system for EBR-2. 14 refs., 43 figs.

  15. Assessment of Startup Fuel Options for the GNEP Advanced Burner Reactor (ABR)

    Energy Technology Data Exchange (ETDEWEB)

    Jon Carmack (062056); Kemal O. Pasamehmetoglu (103171); David Alberstein

    2008-02-01

    The Global Nuclear Energy Program (GNEP) includes a program element for the development and construction of an advanced sodium cooled fast reactor to demonstrate the burning (transmutation) of significant quantities of minor actinides obtained from a separations process and fabricated into a transuranic bearing fuel assembly. To demonstrate and qualify transuranic (TRU) fuel in a fast reactor, an Advanced Burner Reactor (ABR) prototype is needed. The ABR would necessarily be started up using conventional metal alloy or oxide (U or U, Pu) fuel. Startup fuel is needed for the ABR for the first 2 to 4 core loads of fuel in the ABR. Following start up, a series of advanced TRU bearing fuel assemblies will be irradiated in qualification lead test assemblies in the ABR. There are multiple options for this startup fuel. This report provides a description of the possible startup fuel options as well as possible fabrication alternatives available to the program in the current domestic and international facilities and infrastructure.

  16. The value of business incubation services for early stage start-ups

    DEFF Research Database (Denmark)

    Jakobsen, Brian; Tanev, Stoyan; Jensen, Søren

    2017-01-01

    The paper focuses on conceptualizing the value of business incubation services for early stage start-ups that are typical of university-based entrepreneurial ecosystems. The challenge of such conceptualization consists in two main issues. The first issue is taking into account the specificity...... of the needs of early stage start-ups since they: i) do not have a well-articulated business model but work towards establishing one; ii) operate under conditions of significantly high risks and uncertainties; and iii) have not developed the minimum viable set of partners that would enable them to demonstrate...... that they could create value for the different stakeholders involved in their business ecosystem. The second issue is the need to categorize the various types of business incubators before examining the way they create value for early start-ups. In most national or regional entrepreneurial ecosystems...

  17. Practical Considerations of the Start-up Procedure for an Active Capacitor

    DEFF Research Database (Denmark)

    Wang, Haoran; Wang, Qian; Geng, Tao

    2017-01-01

    Capacitive DC links provide the only low-impedance current path connected with an input source during the start-up of many voltage source converters. A soft-start circuit is usually implemented to limit the inrush current. A two-terminal active capacitor is recently proposed which can directly...... replace conventional passive capacitors in DC links, with reduced cost or size for a given application. The active capacitor has the same level of convenience with two power terminals only as a passive capacitor. This paper proposes two start-up schemes for the active capacitor to overcome the drawbacks...... of existing methods previously widely used for passive capacitors. One scheme is based on a trade-off design between the start-up performance and the component sizing of the active capacitor. The other scheme is based on either an additional bypass switch together with the existing soft-start circuit...

  18. The Impact of Institutional Settings on Learning Behavior by Venture Capitalists and Start-Ups

    DEFF Research Database (Denmark)

    Gatti, Anna; Vendelø, Morten Thanning

    2005-01-01

    differen-ces in local institutional settings affect learning and adaptation by European venture ca-pitalists and start-ups, and thus, affect the processes of field formation. For example, it has been observed that institutional settings can facilitate or discourage learning from direct experience (Herriot...... et al., 1985). Thus, depending on the institutional settings venture capitalists and start-ups may rely on diffusion of experience in various degrees. Experiences can diffuse from the US, where venture capitalism as an entrepreneurial form evolved in Silicon Valley in the 1970s. In the US venture...... capitalists represent an institutionalized type of organization with formalized rules and standards, codified be-havior and roles (Suchman, 1995; Suchman et al., 2001). European venture capitalists and start-ups may imitate behavior and rules developed in Silicon Valley, and thus, a second research objective...

  19. Capital Structure in Start-up Firms in the Conditions of the Czech Economy

    Directory of Open Access Journals (Sweden)

    Gabriela Chmelíková

    2014-01-01

    Full Text Available The aim of this article is to characterise the form of capital structures in start-up companies in the Czech economy and to identify what determines them. The choice of theme for this research was motivated by the important role that start-up companies have played in the development of economies especially in its contribution to employment, while having a low empirical understanding of the structure of capital resources of the firms. In this contribution, we have managed to identify the average form of the capital structures of start-up companies in the Czech economy. Moreover, they were in keeping with the Trade-Off Theory of Capital Structure testing the factors determining the composition of the capital resources of the firms. However it was only possible to empirically support the conclusions in part.

  20. Comparison between MBR and SBR on Anammox start-up process from the conventional activated sludge.

    Science.gov (United States)

    Wang, Tao; Zhang, Hanmin; Gao, Dawen; Yang, Fenglin; Zhang, Guangyi

    2012-10-01

    Anammox start-up performances from the conventional activated sludge were compared between a MBR and SBR. Both the reactors successfully started up Anammox process. The start-up period in the MBR (59 days) was notably shorter than that in the SBR (101 days), and the max nitrogen (NH(4)(+)+NO(2)(-)) removal capacity of 345.2 mg N L(-1) d(-1) in the MBR was also higher than that of 292.0 mg N L(-1) d(-1) in the SBR. FISH analysis showed that Anammox bacteria predominated in both reactors. Phylogenetic analysis further disclosed that the MBR had the better biodiversity of Anammox bacteria and gained a higher ecological stability. Generally, the results showed that MBR exhibited a more excellent performance for Anammox start-up. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

  1. Ophthalmic Start-Up Chief Executive Officers' Perceptions of Development Hurdles.

    Science.gov (United States)

    Stewart, William C; Nelson, Lindsay A; Kruft, Bonnie; Stewart, Jeanette A

    2017-08-26

    To identify current challenges facing ophthalmic pharmaceutical start-ups in developing new products. Surveys were distributed to the chief executive officer (CEO) or president of ophthalmic start-ups. The survey attracted 24 responses from 78 surveys distributed (31%). The CEOs stated that a lack of financial capital (n = 18, 75%), FDA regulations (n = 6, 25%), and failure to meet clinical endpoints (n = 6, 25%) were their greatest development hurdles. Risk aversion to medicines in early development (n = 18, 75%), mergers and acquisitions reducing corporate choice for licensing agreements (n = 7, 29%), the emergence of large pharmaceutical-based venture capital funding groups (n = 12, 50%), and the failure of many large pharmaceutical companies to develop their own medicines (n = 10, 42%) were noted as recent prominent trends affecting fundraising. The study suggests that development funding, regulatory burden, and meeting clinical endpoints are the greatest development challenges faced by ophthalmic start-up CEOs. © 2017 S. Karger AG, Basel.

  2. Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers

    Science.gov (United States)

    Park, Joonyoung; Brust, Tarsis F.; Lee, Hong Jae; Lee, Sang Cheon; Watts, Val J.; Yeo, Yoon

    2014-01-01

    The surface of a polymeric nanoparticle (NP) is often functionalized with cell-interactive ligands and/or additional polymeric layers to control NP interaction with cells and proteins. However, such modification is not always straightforward when the surface is not chemically reactive. For this reason, most NP functionalization processes employ reactive linkers or coupling agents or involve pre-functionalization of the polymer, which are complicated and inefficient. Moreover, pre-functionalized polymers can lose the ability to encapsulate and retain a drug if the added ligands change chemical properties of the polymer. To overcome this challenge, we use dopamine polymerization as a way of functionalizing NP surfaces. This method includes brief incubation of the pre-formed NPs in a weak alkaline solution of dopamine, followed by secondary incubation with desired ligands. Using this method, we have functionalized poly(lactic-co-glycolic acid) (PLGA) NPs with three representative surface modifiers: a small molecule (folate), a peptide (Arg-Gly-Asp), and a polymer [poly(carboxybetaine methacrylate)]. We confirmed that the modified NPs showed the expected cellular interactions with no cytotoxicity or residual bioactivity of dopamine. The dopamine polymerization method is a simple and versatile surface modification method, applicable to a variety of NP drug carriers irrespective of their chemical reactivity and the types of ligands. PMID:24628245

  3. Polydopamine-based simple and versatile surface modification of polymeric nano drug carriers.

    Science.gov (United States)

    Park, Joonyoung; Brust, Tarsis F; Lee, Hong Jae; Lee, Sang Cheon; Watts, Val J; Yeo, Yoon

    2014-04-22

    The surface of a polymeric nanoparticle (NP) is often functionalized with cell-interactive ligands and/or additional polymeric layers to control NP interaction with cells and proteins. However, such modification is not always straightforward when the surface is not chemically reactive. For this reason, most NP functionalization processes employ reactive linkers or coupling agents or involve prefunctionalization of the polymer, which are complicated and inefficient. Moreover, prefunctionalized polymers can lose the ability to encapsulate and retain a drug if the added ligands change the chemical properties of the polymer. To overcome this challenge, we use dopamine polymerization as a way of functionalizing NP surfaces. This method includes brief incubation of the preformed NPs in a weak alkaline solution of dopamine, followed by secondary incubation with desired ligands. Using this method, we have functionalized poly(lactic-co-glycolic acid) (PLGA) NPs with three representative surface modifiers: a small molecule (folate), a peptide (Arg-Gly-Asp), and a polymer [poly(carboxybetaine methacrylate)]. We confirmed that the modified NPs showed the expected cellular interactions with no cytotoxicity or residual bioactivity of dopamine. The dopamine polymerization method is a simple and versatile surface modification method, applicable to a variety of NP drug carriers irrespective of their chemical reactivity and the types of ligands.

  4. Strategies for the startup of methanogenic inverse fluidized-bed reactors using colonized particles.

    Science.gov (United States)

    Alvarado-Lassman, A; Sandoval-Ramos, A; Flores-Altamirano, M G; Vallejo-Cantú, N A; Méndez-Contreras, J M

    2010-05-01

    One of the inconveniences in the startup of methanogenic inverse fluidized-bed reactors (IFBRs) is the long period required for biofilm formation and stabilization of the system. Previous researchers have preferred to start up in batch mode to shorten stabilization times. Much less work has been done with continuous-mode startup for the IFBR configuration of reactors. In this study, we prepared two IFBRs with similar characteristics to compare startup times for batch- and continuous-operation modes. The reactors were inoculated with a small quantity of colonized particles and run for a period of 3 months, to establish the optimal startup strategy using synthetic media as a substrate (glucose as a source of carbon). After the startup stage, the continuous- and batch-mode reactors removed more than 80% of the chemical oxygen demand (COD) in 51 and 60 days of operation, respectively; however, at the end of the experiments, the continuous-mode reactor had more biomass attached to the support media than the batch-mode reactor. Both reactors developed fully covered support media, but only the continuous-mode reactor had methane yields close to the theoretical value that is typical of stable reactors. Then, a combined startup strategy was proposed, with industrial wastewater as the substrate, using a sequence of batch cycles followed by continuous operation, which allows stable operation at an organic loading rate of 20 g COD/L x d in 15 days. Using a fraction of colonized support as an inoculum presents advantages, with respect to previously reported strategies.

  5. Starptautiska startup akseleratora izveide Latvijā - nepieciešamības izvērtējums un startup akseleratora modeļa izstrāde

    OpenAIRE

    Zaļais, Kristaps

    2014-01-01

    Bakalaura darba tēma ir „Starptautiska startup akseleratora izveide Latvijā – nepieciešamības izvērtējums un startup akseleratora modeļa izstrāde” Bakalaura darba mērķis ir izvērtēt Latvijas startup vidi, nepieciešamību pēc starptautiska startup akseleratora, kā arī izstrādāt ekonomiski pamatotu potenciālo akseleratoru modeli. Darbs sastāv no trim daļām, kur pirmajā daļā tiek pētītas inovāciju kā arī uzņēmējdarbības nozīme ekonomikā, ka arī teorētiskie aspekti par startup, akseleratoriem. ...

  6. Pomen ustrezne podjetniške ekipe in njene motivacije za uspeh start-up podjetja

    OpenAIRE

    Kumer, Špela

    2015-01-01

    V diplomskem projektu smo podrobneje preučevali vpliv podjetniške ekipe in njene motivacije na uspeh start-up podjetja. V teoretičnem delu smo najprej razložili osnovne pojme, povezane s start-up podjetji ter opisali načine dela, ki se v takih podjetjih uporabljajo. Na kratko smo opisali tudi podjetniški proces, katerega sestavni del je med drugim podjetniška ekipa. Podjetniško ekipo smo raziskovali podrobneje – navedli smo njeno optimalno sestavo, potrebne lastnosti ekipe in izkušnje...

  7. Life Sciences Start-ups in Switzerland: CTI and its Support for Young Entrepreneurs.

    Science.gov (United States)

    Sekanina, Klara

    2014-12-01

    According to the Global Entrepreneurship Monitor 2013, perceived opportunities to start a business in Switzerland are high and rank above average compared to other innovation-based countries. 2013 was a record year for start-ups in Switzerland. Around 40,000 new businesses were recorded in the commercial register and the trend is set to continue. There are two main criteria that lead to success, particularly for science- or technology- based start-ups: first of all, it is the business or product idea itself, and secondly it is the entrepreneurial team. CTI is supporting innovation in a manner that responds to a need in the market identified by industry.

  8. TRAINING OF INNOVATIVE ENTREPRENEURSHIP – A KEY TO CREATION OF STARTUPS

    Directory of Open Access Journals (Sweden)

    Olena KURCHENKO

    2016-07-01

    Full Text Available Innovative startup companies that emerged in the late 1990s are now widely supported by countries with developed innovation systems. The aim of this article is to analyse the experience of creation innovative programs in entrepreneurship, with a further perspective for introducing similar programmes into Ukrainian universities. For this, the authors presented their own developed program of monitoring the Ukrainian universities on availability of courses of innovative entrepreneurship. The results of this survey will be analytical prerequisite for decision-making of establishment special curriculum of innovative entrepreneurship in technical and natural Sciences universities for the development of startup-ecosystem in Ukraine.

  9. Lean and Global Technology Start-ups: Linking the Two Research Streams

    DEFF Research Database (Denmark)

    Lemminger, Roy; Svendsen, Lars Limkilde; Zijdemans, Erik

    2014-01-01

    stream is well established focuses on International New Ventures (INVs) or Born Global (BG) firms (Oviatt & McDougall, 1994; Knight and Cavusgil, 1996); the second one is in the process of emerging and deals with lean start-ups (Ries, 2011; Blank, 2013). It is our intention to show that the problems...... be summarized as follows: a) How do new technology start-ups narrow down the scope of their business activities by effectuating the global dimensions of their businesses? What are the reasons for such firms to look for global resources, partnerships or markets right from inception? b) What makes it possible...

  10. Start-up conditions and the performance of women - and men - controlled businesses in manufacturing industries

    Directory of Open Access Journals (Sweden)

    Otilia Driga

    2010-01-01

    Full Text Available Recent research into the economic performance of women-controlled firms suggests that their underperformance may not be the result of differences in the managerial ability of women as compared to men, and that it may in fact be a consequence of differing levels of start-up resources. Using accounting data, we examine the effects that selected start-up conditions have had on the observed economic performance of a sample of 4450 Spanish manufacturing firms. The results, which indicate significant differences in the initial conditions and show lower levels of assets and employee numbers in women-controlled firms, have implications for the economic performance of such firms.

  11. An investigation of the side force that is sometimes observed in rocket start-up

    Science.gov (United States)

    Bowyer, J. M., Jr.; Kreiter, G. W.; Petersen, R. E.

    1978-01-01

    The occurrence of a large but momentary side force during the start-up of rocket motors employing convergent-divergent nozzles has been noted occasionally. Asymmetric flow separation within the divergent section of the nozzle is proposed as the principal source of this lateral force. A method for estimating this force and its concomitant lateral impulse is outlined, and results obtained by applying the method to Scout vehicle first-, second-, and third-stage rocket motor start-ups are presented and compared with similar estimates that other researchers obtained by a different method.

  12. Creating E-Commerce Start-Ups with Information Systems Students: Lessons Learned from New Venture Successes and Failures

    Science.gov (United States)

    Abrahams, Alan

    2010-01-01

    In this paper, we review a variety of e-commerce startups created by senior information systems students, under the author's guidance, over a number of years at multiple universities. We compare the characteristics of the start-ups and comment on various factors which appear to have contributed to their success or failure. Our recommendations are…

  13. A New Method for Start-up of Isolated Boost Converters Using Magnetic- and Winding-Integration

    DEFF Research Database (Denmark)

    Lindberg-Poulsen, Kristian; Ouyang, Ziwei; Sen, Gökhan

    2012-01-01

    A new solution to the start-up and low output voltage operation of isolated boost family converters is presented. By the use of integrated magnetics and winding integration, the transformer secondary winding is re-used during start-up as a flyback winding coupled to the boost inductor. The tradit...

  14. Study on ECH-assisted start-up using trapped particle configuration in KSTAR and application to ITER

    Science.gov (United States)

    Lee, Jeongwon; Kim, Jayhyun; An, YoungHwa; Yoo, Min-Gu; Hwang, Y. S.; Na, Yong-Su

    2017-12-01

    ECH-assisted start-up using trapped particle configuration (TPC) is firstly studied in a superconducting, conventional tokamak, KSTAR. First, improved and efficient start-up using TPC than conventional field null configuration (FNC) is achieved by enhanced pre-ionization plasma quality. TPC shows the broader operation window in terms of the poloidal field quality and the deuterium prefill pressure than that of FNC. Surprisingly the particle trapping enhances the plasma start-up performance even with much lower particle trapping ratio than that of spherical torus. Reliability of TPC with low trapping ratio is investigated by 0D plasma evolution code, TECHP0D. Second, the characteristics of TPC start-up are explored with experiments and modellings. Two kind of start-up failure conditions are identified by the magnetic pitch and prefill pressure scan experiments: (i) low ionization rate; and (ii) low density condition. These experimental observation has consistency with TECHP0D modeling result. Finally, reliable ITER-relevant low toroidal electric field start-up using TPC is achieved with drastically improved success rate of start-up in KSTAR. In this experiments, validity of the ITER-like toroidally inclined ECH/ECCD injection is also expected. Time dependent ITER start-up scenario using TPC is proposed and the superiority of it than FNC is discussed.

  15. Trademark or patent? The effects of market structure, customer type and venture capital financing on start-ups' IP decisions

    NARCIS (Netherlands)

    A.G.B. de Vries (Geertjan); H.P.G. Pennings (Enrico); J.H. Block (Jörn)

    2013-01-01

    textabstractWe analyze the initial intellectual property (IP) right of 4,703 start-up entrants in the US, distinguishing between trademark and patent applications. The results show that start-ups are more likely to file for a trademark instead of a patent when entering into more competitive market

  16. Versatility of peroxisomes: An evolving concept.

    Science.gov (United States)

    Deb, Rachayeeta; Nagotu, Shirisha

    2017-04-01

    Research spanning almost 50 years has highlighted unique characteristics and irreplaceable list of diverse functions performed by peroxisomes in various model systems. Peroxisomes are single membrane bound highly dynamic organelles ubiquitous to most eukaryotic cells. Proliferation by division of pre-existing organelles and the role of endoplasmic reticulum in the biogenesis of these organelles is now well established. The earliest identified conserved functions of peroxisomes are β-oxidation of fatty acids and reactive oxygen species metabolism. Several studies over the last few decades have reported the importance of this organelle and its numerous cell type, tissue and environment-dependent functions. Their role in several aspects of human health and disease is now under investigation. Studies related to peroxisome biology and functions are now also extended to diverse model systems like Drosophila melanogaster, trypanosomatids, etc. Peroxisomes also intricately collaborate and carry out these functions together with several other organelles in a cell. In this review, we aim to present an overview of our current knowledge of the repertoire of functions of peroxisomes in various model systems. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Start-Up of an Anaerobic Dynamic Membrane Digester for Waste Activated Sludge Digestion: Temporal Variations in Microbial Communities

    Science.gov (United States)

    Yu, Hongguang; Wang, Qiaoying; Wang, Zhiwei; Sahinkaya, Erkan; Li, Yongli; Ma, Jinxing; Wu, Zhichao

    2014-01-01

    An anaerobic dynamic membrane digester (ADMD) was developed to digest waste sludge, and pyrosequencing was used to analyze the variations of the bacterial and archaeal communities during the start-up. Results showed that bacterial community richness decreased and then increased over time, while bacterial diversity remained almost the same during the start-up. Proteobacteria and Bacteroidetes were the major phyla. At the class level, Betaproteobacteria was the most abundant at the end of start-up, followed by Sphingobacteria. In the archaeal community, richness and diversity peaked at the end of the start-up stage. Principle component and cluster analyses demonstrated that archaeal consortia experienced a distinct shift and became stable after day 38. Methanomicrobiales and Methanosarcinales were the two predominant orders. Further investigations indicated that Methanolinea and Methanosaeta were responsible for methane production in the ADMD system. Hydrogenotrophic pathways might prevail over acetoclastic means for methanogenesis during the start-up, supported by specific methanogenic activity tests. PMID:24695488

  18. Start-up of an anaerobic dynamic membrane digester for waste activated sludge digestion: temporal variations in microbial communities.

    Science.gov (United States)

    Yu, Hongguang; Wang, Qiaoying; Wang, Zhiwei; Sahinkaya, Erkan; Li, Yongli; Ma, Jinxing; Wu, Zhichao

    2014-01-01

    An anaerobic dynamic membrane digester (ADMD) was developed to digest waste sludge, and pyrosequencing was used to analyze the variations of the bacterial and archaeal communities during the start-up. Results showed that bacterial community richness decreased and then increased over time, while bacterial diversity remained almost the same during the start-up. Proteobacteria and Bacteroidetes were the major phyla. At the class level, Betaproteobacteria was the most abundant at the end of start-up, followed by Sphingobacteria. In the archaeal community, richness and diversity peaked at the end of the start-up stage. Principle component and cluster analyses demonstrated that archaeal consortia experienced a distinct shift and became stable after day 38. Methanomicrobiales and Methanosarcinales were the two predominant orders. Further investigations indicated that Methanolinea and Methanosaeta were responsible for methane production in the ADMD system. Hydrogenotrophic pathways might prevail over acetoclastic means for methanogenesis during the start-up, supported by specific methanogenic activity tests.

  19. Start-Up Entrepreneurs and University Students in a Co-Learning Mode: Learning Effects of a Collaborative Entrepreneurial Coaching Programme

    Science.gov (United States)

    Saukkonen, Juha; Nukari, Jussi; Ballard, Sharon; Levie, Jonathan

    2016-01-01

    Start-up companies have been recognized as key drivers of wealth and job creation. Many students now in universities will therefore find their future employment in start-up companies, or will found them. Success in the start-up environment requires a specific set of skills. There is a growing supply of university education for new venture creation…

  20. Entrepreneurship Education: Enhancing or Discouraging Graduate Start-Up at the University of Pretoria

    Science.gov (United States)

    Botha, Melodi; Ras, Rochelle

    2016-01-01

    In-depth interviews were conducted with a sample of BCom Entrepreneurship graduates, as well as a control group to determine whether the exposure to entrepreneurship education can enhance actual business start-up. Information was collected on how they experienced the learning approaches, and the value which they had derived from the degree. This…

  1. The Perfect Pairing: The Adult Learner and the Boutique Winery in the Start-Up Phase

    Science.gov (United States)

    Heath-Simpson, Delta F.

    2011-01-01

    The purpose of this phenomenological study was to understand and describe the lived experiences of adult learners who are owners and managers of small winery businesses operating in the start-up phase of the organizational life cycle. The study explored and identified the meaning of adult learning in the entrepreneurial context and its affect on…

  2. Internet of Things: Business plan for an early-stage technology driven start-up

    OpenAIRE

    Verteletskyi, Maksym

    2016-01-01

    The goal of the thesis is to write a business plan for an early stage internet of things startup, specializing in indoor safety & facility management. Evaluate the potential of this business idea and its value proposition. Select the proper entry markets and calculate financial projections. Do it in such way that it would be acceptable by investors interested in making capital inputs.

  3. Start-up of world's largest isobutane dehydrogenation plant for MTBE production

    Energy Technology Data Exchange (ETDEWEB)

    Al-Ghamdi, A.A. (Saudi European Petrochemical Co. Ibn Zahr, Al-Sinaiyah (Saudi Arabia)); Al-Bassam, A.M. (Saudi Basic Industries Corp., Riyadh (Saudi Arabia)); Draus, J.L. (ABB Lummus Crest, Inc., Bloomfield, NJ (United States))

    1994-01-01

    Ibn Zahr's second CATOFIN[reg sign] dehydrogenation unit started on schedule with an exceptionally smooth and fast start-up. The success of the start-up can be attributed to many factors, including: competent and experienced commissioning and operations teams from both the owner and licensor (ABB Lummus Crest); well proven CATOFIN technology; and vendor representation on site. All process guarantees were met in a test run completed three weeks after the start-up. Ibn Zahr chose the CATOFIN process to produce isobutylene feed for both of their MTBE plants located in the Al Jubail Industrial City in the Kingdom of Saudi Arabia. The first CATOFIN plant came on stream in 1988 producing 320,000 MTA of isobutylene. The second CATOFIN plant is the largest dehydrogenation unit in the world, producing 452,000 MTA of isobutylene. It came on stream in October, 1993. With the two CATOFIN plants, Ibn Zahr has a combined MTBE production of 1,200,000 MTA (equivalent to 30,000 BPSD). This paper describes the successful start-up of Ibn Zahr's second CATOFIN plant.

  4. Rapid startup of thermophilic anaerobic digester to remove tetracycline and sulfonamides resistance genes from sewage sludge.

    Science.gov (United States)

    Xu, Rui; Yang, Zhao-Hui; Wang, Qing-Peng; Bai, Yang; Liu, Jian-Bo; Zheng, Yue; Zhang, Yan-Ru; Xiong, Wei-Ping; Ahmad, Kito; Fan, Chang-Zheng

    2018-01-15

    Spread of antibiotic resistance genes (ARGs) originating from sewage sludge is highlighted as an eminent health threat. This study established a thermophilic anaerobic digester using one-step startup strategy to quickly remove tetracycline and sulfonamides resistance genes from sewage sludge. At least 20days were saved in the startup period from mesophilic to thermophilic condition. Based on the results of 16S rDNA amplicons sequencing and predicted metagenomic method, the successful startup largely relied on the fast colonization of core thermophilic microbial population (e.g. Firmicutes, Proteobacteria, Actinobacteria). Microbial metabolic gene pathways for substrate degradation and methane production was also increased by one-step mode. In addition, real-time quantitative PCR approach revealed that most targeted tetracycline and sulfonamides resistance genes ARGs (sulI, tetA, tetO, tetX) were substantially removed during thermophilic digestion (removal efficiency>80%). Network analysis showed that the elimination of ARGs was attributed to the decline of their horizontal (intI1 item) and vertical (potential hosts) transfer-related elements under high-temperature. This research demonstrated that rapid startup thermophilic anaerobic digestion of wastewater solids would be a suitable technology for reducing quantities of various ARGs. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Barriers to Start-Up and Their Effect on Aspirant Entrepreneurs

    Science.gov (United States)

    Robertson, Martyn; Collins, Amanda; Medeira, Natasha; Slater, James

    2003-01-01

    The importance of new business start-ups cannot be over-emphasised. The UK government has taken actions designed to stimulate the growth of new businesses and aid their survival. The identification of barriers to entry is important, together with strategies to minimise their impact. The UK continues to lag behind the USA in its levels of…

  6. LightCDD: a lightweight capability-driven development method for start-ups

    NARCIS (Netherlands)

    Koç, Hasan; Ruiz Carmona, L.M.; Espana Cubillo, S.

    2016-01-01

    Novice innovators and entrepreneurs face the risk of designing naive business models. In fact, lack of realism and failing to envision contextual constraints is one of the main threats to start-up success. Both the literature and the responses we gathered from experts in incubation confirm this

  7. LightCDD: Application of a Capability-Driven Development Method for Start-ups Development

    NARCIS (Netherlands)

    Koç, Hasan; Ruiz, Marcela|info:eu-repo/dai/nl/413321002; España, Sergio|info:eu-repo/dai/nl/412500949

    2017-01-01

    Novice innovators and entrepreneurs face the risk of designing naive business models. In fact, lack of viability in business models is perceived to be a major threat for the start-up success. Both the literature and the responses we gathered from experts in incubation present evidences of this

  8. PCDD/F emissions during startup and shutdown of a hazardous waste incinerator.

    Science.gov (United States)

    Li, Min; Wang, Chao; Cen, Kefa; Ni, Mingjiang; Li, Xiaodong

    2017-08-01

    Compared with municipal solid waste incineration, studies on the PCDD/F emissions of hazardous waste incineration (HWI) under transient conditions are rather few. This study investigates the PCDD/F emission level, congener profile and removal efficiency recorded during startup and shutdown by collecting flue gas samples at the bag filter inlet and outlet and at the stack. The PCDD/F concentration measured in the stack gas during startup and shutdown were 0.56-4.16 ng I-TEQ Nm(-3) and 1.09-3.36 ng I-TEQ Nm(-3), respectively, far exceeding the present codes in China. The total amount of PCDD/F emissions, resulting from three shutdown-startup cycles of this HWI-unit is almost equal to that generated during one year under normal operating conditions. Upstream the filter, the PCDD/F in the flue gas is mainly in the particle phase; however, after being filtered PCDD/F prevails in the gas phase. The PCDD/F fraction in the gas phase even exceeds 98% after passing through the alkaline scrubber. Especially higher chlorinated PCDD/F accumulate on inner walls of filters and ducts during these startup periods and could be released again during normal operation, significantly increasing PCDD/F emissions. Copyright © 2017. Published by Elsevier Ltd.

  9. Improving startup performance with carbon mesh anodes in separator electrode assembly microbial fuel cells

    KAUST Repository

    Zhang, Fang

    2013-04-01

    In a separator electrode assembly microbial fuel cell, oxygen crossover from the cathode inhibits current generation by exoelectrogenic bacteria, resulting in poor reactor startup and performance. To determine the best approach for improving startup performance, the effect of acclimation to a low set potential (-0.2V, versus standard hydrogen electrode) was compared to startup at a higher potential (+0.2V) or no set potential, and inoculation with wastewater or pre-acclimated cultures. Anodes acclimated to -0.2V produced the highest power of 1330±60mWm-2 for these different anode conditions, but unacclimated wastewater inocula produced inconsistent results despite the use of this set potential. By inoculating reactors with transferred cell suspensions, however, startup time was reduced and high power was consistently produced. These results show that pre-acclimation at -0.2V consistently improves power production compared to use of a more positive potential or the lack of a set potential. © 2013 Elsevier Ltd.

  10. 40 CFR 63.310 - Requirements for startups, shutdowns, and malfunctions.

    Science.gov (United States)

    2010-07-01

    ... occurred. (j) The owner or operator of a nonrecovery coke oven battery subject to the work practice... CATEGORIES National Emission Standards for Coke Oven Batteries § 63.310 Requirements for startups, shutdowns... or operator shall operate and maintain the coke oven battery and its pollution control equipment...

  11. Ed Tech Developer's Guide: A Primer for Software Developers, Startups, and Entrepreneurs

    Science.gov (United States)

    Bienkowski, Marie; Gerard, Sarah Nixon; Rubin, Shawn; Sanford, Cathy; Borrelli-Murray, Dana; Driscoll, Tom; Arora, Jessie; Hruska, Mike; Beck, Katie; Murray, Thomas; Hoekstra, Jason; Gannes, Stuart; Metz, Edward; Midgley, Steve; Castilla, Stephanie; Tomassini, Jason; Madda, Mary Jo; Chase, Zac; Martin, Erik; Noel, Marcus; Styles, Kathleen

    2015-01-01

    Opportunities abound for software designers and developers to create impactful tools for teachers, school leaders, students, and their families. This guide for developers, startups, and entrepreneurs addresses key questions about the education ecosystem and highlights critical needs and opportunities to develop digital tools and apps for learning.…

  12. The Impact of Start-up Grants on Firm Performance in Estonia

    Directory of Open Access Journals (Sweden)

    Siret Vildo

    2013-01-01

    Full Text Available As in economic theory start-up enterprises have been seen as important sources of growth, the government support measures to enterprises have been a common practice around the world for decades. As the governmental support to enterprises is often of a considerable amount of money there is a need to assess its efficiency. In the present article we study the impact of Estonian start-up grants distributed in 2002 and 2003 on various indicators of firm performance with econometric methods, namely propensity score matching. We use the data from the Estonian Business Register in order to study the impact of start-up grants on various economic indicators like the number of employees, turnover, equity, fixed assets and firm survival. The results showed that the start-up grants proved to affect positively the number of employed people and turnover, yet the impact on productivity was negative. One implication of the study is that it is difficult to achieve different goals to the same extent with a single governmental grant

  13. Smart or diverse start-up teams? Evidence from a field experiment

    NARCIS (Netherlands)

    Hoogendoorn, S.; Parker, S.C.; van Praag, M.

    2017-01-01

    This paper explores the relationship between cognitive abilities and team performance in a start-up setting. We argue that performance in this setting hinges on three tasks: opportunity recognition, problem solving, and implementation. We theorize that cognitive ability at the individual level has a

  14. Ideology as Resource in Entrepreneurial Journalism : The French online news startup Mediapart

    NARCIS (Netherlands)

    Wagemans, Andrea; Witschge, Tamara; Deuze, Mark

    2016-01-01

    The emergence of a startup culture in the field of journalism is global: since the early years of the twenty-first century, new independent journalism companies have formed around the world. Although setting up one's own journalistic practice is not particularly novel in the news industry, the last

  15. Achieving and Sustaining New Knowledge Development in High-Expectation Start-Ups

    Science.gov (United States)

    Matricano, Diego

    2010-01-01

    In markets characterized by strong competition, new knowledge and new knowledge development are generally recognized as the key means for an enterprise to gain competitive advantage. This knowledge-based competitive advantage is critical for all commercial ventures, but is especially so for high-expectation start-ups (technology-based ventures…

  16. The Influence of Innovation and Entrepreneurial Self-Efficacy to Digital Startup Success

    Directory of Open Access Journals (Sweden)

    Agnes Dessyana

    2017-08-01

    Full Text Available Establishing and developing a startup business is not easy. Startup success depend on various aspects, such as financial,business model, and learning organizations. Personalities factor of founders have a contribution in business development, especially entrepreneurial self-efficacy (ESE and innovation. But, in Indonesia, there is still no psychological study who see the contribution of those factors on business success in digital startup. This study aimed to understand how both factors influence startup digital. The sample is 64 founders. The research instrument is ESE, KAI, and Business Success questionnaire (Kirton in Riyanti, 2003; Chen et al, 1998; Kaplan & Norton, 2006. Multiple-regression analyses reveal ESE and innovation contributes 20.8% to business success. ESE regression coefficient is 0.200 (P 0.05. This means, ESE has significant positive effect, while innovation has a positive relationship but insignificant. Interventions in the form of booklets that inform how to increase ESE. The booklet is already conducted trials on five founders.

  17. Analysis of Startup Process and Its Optimization for a Two-Stand Reversible Cold Rolling Mill

    Directory of Open Access Journals (Sweden)

    Guangming Liu

    2017-01-01

    Full Text Available Dynamic characteristic analysis of a two-stand reversible cold rolling mill in the startup process was carried out. The delay algorithm of the interstand thickness was proposed. A new method combined with the accelerated secant and the tangent methods was established to solve the simultaneous equations. The thickness and interstand tension transition processes with different static tension establishing processes were analyzed. Both mills were operated under constant rolling force control mode in the above process. The results show that the strip thickness in the rolling gap reduces in the static mill screwdown process. The entry stand runs inversely to establish the static interstand tension. This area becomes an abnormal thickness reduction area of the incoming strip. It results in several abnormal interstand tension increases in the subsequent startup process. The tension increase leads to an impact force on the strip that is the main reason of the strip breakage in the startup process. So the static tension establishing process was optimized, and the interstand tension fluctuation and the strip breakage accidents both reduced significantly. The results are beneficial to the startup process of the two-stand reversible cold rolling mill.

  18. Improving startup performance with carbon mesh anodes in separator electrode assembly microbial fuel cells.

    Science.gov (United States)

    Zhang, Fang; Xia, Xue; Luo, Yong; Sun, Dan; Call, Douglas F; Logan, Bruce E

    2013-04-01

    In a separator electrode assembly microbial fuel cell, oxygen crossover from the cathode inhibits current generation by exoelectrogenic bacteria, resulting in poor reactor startup and performance. To determine the best approach for improving startup performance, the effect of acclimation to a low set potential (-0.2V, versus standard hydrogen electrode) was compared to startup at a higher potential (+0.2 V) or no set potential, and inoculation with wastewater or pre-acclimated cultures. Anodes acclimated to -0.2 V produced the highest power of 1330±60 mW m(-2) for these different anode conditions, but unacclimated wastewater inocula produced inconsistent results despite the use of this set potential. By inoculating reactors with transferred cell suspensions, however, startup time was reduced and high power was consistently produced. These results show that pre-acclimation at -0.2 V consistently improves power production compared to use of a more positive potential or the lack of a set potential. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. Running Lean Startup in the Classroom: From Idea to Experiment in 1 Week

    Science.gov (United States)

    Armstrong, Craig E.

    2017-01-01

    Entrepreneurship education is increasingly shifting from learning about entrepreneurship to developing entrepreneurial skills. One skill all entrepreneurship students need to develop is the ability to assess whether or not there is a market for their new product or service. Recent popular trade books like Eric Ries's "Lean Startup" and…

  20. On the breakdown modes and parameter space of Ohmic Tokamak startup

    Science.gov (United States)

    Peng, Yanli; Jiang, Wei; Zhang, Ya; Hu, Xiwei; Zhuang, Ge; Innocenti, Maria; Lapenta, Giovanni

    2017-10-01

    Tokamak plasma has to be hot. The process of turning the initial dilute neutral hydrogen gas at room temperature into fully ionized plasma is called tokamak startup. Even with over 40 years of research, the parameter ranges for the successful startup still aren't determined by numerical simulations but by trial and errors. However, in recent years it has drawn much attention due to one of the challenges faced by ITER: the maximum electric field for startup can't exceed 0.3 V/m, which makes the parameter range for successful startup narrower. Besides, this physical mechanism is far from being understood either theoretically or numerically. In this work, we have simulated the plasma breakdown phase driven by pure Ohmic heating using a particle-in-cell/Monte Carlo code, with the aim of giving a predictive parameter range for most tokamaks, even for ITER. We have found three situations during the discharge, as a function of the initial parameters: no breakdown, breakdown and runaway. Moreover, breakdown delay and volt-second consumption under different initial conditions are evaluated. In addition, we have simulated breakdown on ITER and confirmed that when the electric field is 0.3 V/m, the optimal pre-filling pressure is 0.001 Pa, which is in good agreement with ITER's design.

  1. Ideology as resource in entrepreneurial journalism: The French online news startup Mediapart

    NARCIS (Netherlands)

    Wagemans, A.; Witschge, T.; Deuze, M.

    2016-01-01

    The emergence of a startup culture in the field of journalism is global: since the early years of the twenty-first century, new independent journalism companies have formed around the world. Although setting up one’s own journalistic practice is not particularly novel in the news industry, the last

  2. Haiti Start-Up mission design cold chain mango-avocado

    NARCIS (Netherlands)

    Oostewechel, René; Régis, Yves-Laurent; Brouwers, Jan

    2018-01-01

    This report shares the findings of the first start-up mission to Haiti, exploring all relevant elements pertaining to the design of the mango and avocado cold chain for fruit export to the USA, with the possibility to extend logistics services to other fruits like pineapple. Findings of the mission

  3. Network effects on Entrepreneurial Processes: Start-ups in the Dutch ICT Industry 1990-2000

    NARCIS (Netherlands)

    W. Hulsink (Wim); T. Elfring (Tom)

    2003-01-01

    textabstractThe value of networks as an integral part of the explanation of entrepreneurial success is widely acknowledged. It is unclear, however, in what way certain networks influence the success of start-up companies. The question of this paper is: 'in what way does the entrepreneur's network

  4. Human Resource Blueprints in Irish High-Tech Start-Up Firms

    Science.gov (United States)

    Keating, Mary A.; Olivares, Mariabrisa

    2006-01-01

    Focusing on Irish high-tech start-ups, this paper reports on the results of an empirical study of organization building by entrepreneurial firms, specifically in relation to human resource practices. The research findings are benchmarked with findings from SPEC, the Stanford Project of Emerging Companies (Baron and Hannan, 2002). Human resources…

  5. What's New in the Launching of Start-Ups? Features and Implications of Laboratory Experiments

    Science.gov (United States)

    Matricano, Diego

    2009-01-01

    This article responds to "Laboratory experiments as a tool in the empirical economic analysis of high-expectation start-ups" by Martin Curley and Piero Formica, published in the December 2008 issue of "Industry and Higher Education." The exploitation of knowledge and experience is increasingly important to companies operating in the globalized…

  6. Experimental Labs for Start-Ups: The Role of the "Venture-Sitter"

    Science.gov (United States)

    Matricano, Diego; Pietrobon, Alberto

    2010-01-01

    Curley and Formica's (2008, 2010) studies of high-expectation entrepreneurship focus on the role of "experimental laboratories" in promoting the start-up and successful development of high-expectation firms. Although it is not difficult to understand the potential usefulness of these experimental labs--business simulators in which skilled partners…

  7. Knowledge Management in Startups: Systematic Literature Review and Future Research Agenda

    Directory of Open Access Journals (Sweden)

    Piera Centobelli

    2017-03-01

    Full Text Available This paper conducts a systematic literature review on knowledge management (KM in the context of startups in order to analyze the state of the art, identify research gaps and define a future research agenda. The main findings highlight that, even though there is an increasing number of papers on the topic of KM in startups, several issues are still neglected. Specifically, the paper identifies four main gaps in the body of literature. The first gap deals with the environmental and socio-political factors influencing the adoption of KM in startups. The second gap regards the lack of a comprehensive taxonomy of knowledge management systems (KMSs that may support the processes of knowledge creation, acquisition, storage, transfer, sharing and application. This second gap allows us to identify a third gap concerning the level of alignment between startup’s strategies and technologies adopted. Finally, the fourth gap deals with the issue of the impact of KM on startup’s performances with regard to economic, financial, market, technical, technological, organizational, human and relational performance. From these four gaps, six research questions (RQs have been proposed. These RQs allow us to identify possible areas of analysis to define a future research agenda. Neglecting these issues means underestimating all the possible advantages of KM adoption for a startup to achieve efficiency, effectiveness and scalability goals.

  8. The Impact of Domestic Drivers and Barriers on the Entrepreneurial Start-up Decision

    NARCIS (Netherlands)

    Lubberink, R.J.B.; Blok, V.; Ophem, van J.; Omta, S.W.F.

    2013-01-01

    This paper explores the impact of the family network on the start-up decision byidentifying domestic drivers and barriers to entrepreneurship. For this, we used anadjusted model of work-family conflict theory, with special attention to the family lifecycle stages. In order to identify the drivers

  9. Optimisation of sampling system for a faster start-up of cycling power plants

    Energy Technology Data Exchange (ETDEWEB)

    Soellner, Anke [Siemens AG Energy Solution, Erlangen (Germany). Center of Technology; Rziha, Michael [Siemens AG Energy Solution, Erlangen (Germany). Plant Cleaning and Chemistry; Wuhrmann, Peter [Swan Analytische Instrumente AG, Hinwil (Switzerland)

    2010-07-01

    Due to the ongoing liberalisation of the power market, combined cycle power plants operate frequently in cycling mode (approximately 200 hot starts, 50 warm starts per year). The Siemens turbine guideline allows an earlier start of the steam turbine (ST) under restricted conditions. Test results showed that about 100 minutes start-up time can be gained. (orig.)

  10. Social and Environmental Considerations within the IT Sector: Evidence from Romanian Start-Ups

    Directory of Open Access Journals (Sweden)

    Irina-Eugenia Iamandi

    2016-12-01

    Full Text Available The research purpose of the present paper is to investigate the nature and depth of integrating social and environmental requirements into daily economic activities of Romanian start-ups from technology and Internet-related business sectors. As such, more than 150 already launched start-ups in Romania were analysed according to their economic, social and environmental scopes, on a scale quantifying their involvement degree. The results emphasize that, although economically-driven in most of the cases, the technology and Internet-related start-ups in Romania are increasingly considering the social and environmental concerns. This finding refers to the strategic inclusion of the sustainability requirements in their object of activity and inner core of their business, and not to mere corporate social responsibility (CSR pursuits. The conclusion emphasizes a new business pattern implemented by Romanian start-ups in the technology, information and Internet-related domains, where economic, social and environmental requirements are considered together when the corporate business strategy is formulated on the long run.

  11. Harvesting the results of the mentoring process of knowledge intensive startups

    NARCIS (Netherlands)

    Weijman, Geertjan; van der Sijde, Peter; van Benthem, Jann W.L.

    2008-01-01

    Mentoring is often used by business development programs to assist startups. In this paper we look at the perceptions of protégés and mentors about this process, hereby different business development programs in Europe were incorporated. It was hypothesized that there is a relationship between

  12. Unpainting the black box : exploring mechanisms and practices of start-up incubators

    NARCIS (Netherlands)

    van Weele, M.A.

    2016-01-01

    Although incubators have become one of the most prominent instruments to stimulate the emergence and growth of start-ups, questions are being raised about their effectiveness. One major obstacle to evaluate the effectiveness of incubators is that the incubator remains a ‘black box’: the extant

  13. Graduate Career-Making and Business Start-Up: A Literature Review

    Science.gov (United States)

    Nabi, Ghulam; Holden, Rick; Walmsley, Andreas

    2006-01-01

    Purpose: The purpose of this article is to provide a selective review of literature on the career-related decision-making processes in terms of the transition from student to business start-up, and the nature and influence of support and guidance. Design/methodology/approach: Primarily, a critical review of a range of recently published literature…

  14. Partnering with the NIH: Now part of the "Value Proposition" for start-ups.

    Science.gov (United States)

    Ferguson, Steven M

    2012-04-01

    With its "value proposition" statement a start-up company needs to convince potential investors or pharma partners how it will add more value or solve a problem better than others. High value, low cost assets such as those from the NIH ranging from technology to funding to assistance provide such biomedical firms an excellent jump-start in reaching their goals.

  15. StartUp Workbook : Your quest for a scalable and repeatable business model

    NARCIS (Netherlands)

    Coelman, B. (Berrie)

    2014-01-01

    This is the second edition of the Startup Workbook. This workbook is different from the first version. The first version, which was made with a so called touch-grant from Saxion, was primarily a digital version. In addition, the book was printed as a deluxe edition in a limited number of copies. The

  16. LightCDD: Application of a Capability-Driven Development Method for Start-ups Development

    Directory of Open Access Journals (Sweden)

    Hasan Koç

    2017-04-01

    Full Text Available Novice innovators and entrepreneurs face the risk of designing naive business models. In fact, lack of viability in business models is perceived to be a major threat for the start-up success. Both the literature and the responses we gathered from experts in incubation present evidences of this problem. The LightCDD method helps entrepreneurs in the analysis, design and specification of start-ups that are context aware and adaptive to contextual changes and evolution. In this article we describe the LightCDD method, a context-aware enterprise modeling method that is tailored for business model generation. The LightCDD applies a lightweight Capability‑Driven Development (CDD methodology. It reduces the set of modeling constructs and guidelines to facilitate its adoption by entrepreneurs, yet keeping it expressive enough for their purposes and, at the same time, compatible with the CDD methodology. We provide a booklet with the LightCDD method for start-ups development. The feasibility of the LightCDD method is validated by means of its application to one start-up development case. From a practitioner viewpoint (entrepreneurs and experts in incubation, it is important to provide integrative modeling perspectives to specify business ideas, but it is vital to keep it light. The LightCDD is giving a step forward in this direction. From a researcher point of view, the LightCDD booklet facilitates the application of LightCDD to different start-up development cases. The feasibility validation has produced important feedback for further empirical validation exercises in which is necessary to study the scalability and sensitivity of LightCDD.

  17. Reactive Kripke semantics

    CERN Document Server

    Gabbay, Dov M

    2013-01-01

    This text offers an extension to the traditional Kripke semantics for non-classical logics by adding the notion of reactivity. Reactive Kripke models change their accessibility relation as we progress in the evaluation process of formulas in the model. This feature makes the reactive Kripke semantics strictly stronger and more applicable than the traditional one. Here we investigate the properties and axiomatisations of this new and most effective semantics, and we offer a wide landscape of applications of the idea of reactivity. Applied topics include reactive automata, reactive grammars, rea

  18. Versatile Hydrogen-Hydrogen Bond with a Difference

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 1; Issue 6. Versatile Hydrogen-Hydrogen Bond with a Difference. A G Samuelson. Research News Volume 1 Issue 6 June 1996 pp 87-89. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/001/06/0087-0089 ...

  19. Flexible macrocycles as versatile supports for catalytically active metal clusters

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, JD; Gagnon, KJ; Teat, SJ; McIntosh, RD

    2016-02-12

    Here we present three structurally diverse clusters stabilised by the same macrocyclic polyphenol; t-butylcalix[8]arene. This work demonstrates the range of conformations the flexible ligand is capable of adopting, highlighting its versatility in metal coordination. In addition, a Ti complex displays activity for the ring-opening polymerisation of lactide

  20. A versatile route to benzodiazocine and spiropyran derivatives ...

    Indian Academy of Sciences (India)

    125, No. 3, May 2013, pp. 517–524. c Indian Academy of Sciences. A versatile route to benzodiazocine and spiropyran derivatives through chalcones. JOHNSON GEORGEa, SAURABH SINGHa,. RAHUL JOSHIa and RAMCHAND T PARDASANIb,∗. aDepartment of Chemistry, University of Rajasthan, Jaipur 302 055, India.

  1. Propeller Flap for Complex Distal Leg Reconstruction: A Versatile ...

    African Journals Online (AJOL)

    A Versatile Alternative when Reverse Sural Artery Flap is. Not Feasible. Samuel A. Ademola, Afieharo I. Michael, Femi .... flaps that were raised in the patient and the logistics of limb positioning after application of external fixators for bone ... Financial support and sponsorship. Nil. Conflicts of interest. There are no conflicts of ...

  2. Soybean ( Glycine max ) as a versatile biocatalyst for organic ...

    African Journals Online (AJOL)

    Soybean ( Glycine max ) as a versatile biocatalyst for organic synthesis. ... Most of the obtained alcohols have commercial value as cosmetic fragrances. Although, the enzymes present in soybean (reductase/lipase) has not been defined, the reaction is an important route for the preparation of pure alcohols and carboxylic ...

  3. Propeller Flap for Complex Distal Leg Reconstruction: A Versatile ...

    African Journals Online (AJOL)

    Reverse sural artery fasciocutaneous flap has become a workhorse for the reconstruction of distal leg soft ... A Versatile Alternative when Reverse Sural Artery Flap is. Not Feasible. Samuel A. Ademola, Afieharo I. .... flaps that were raised in the patient and the logistics of limb positioning after application of external fixators ...

  4. Versatile Desktop Experiment Module (DEMo) on Heat Transfer

    Science.gov (United States)

    Minerick, Adrienne R.

    2010-01-01

    This paper outlines a new Desktop Experiment Module (DEMo) engineered for a chemical engineering junior-level Heat Transfer course. This new DEMo learning tool is versatile, fairly inexpensive, and portable such that it can be positioned on student desks throughout a classroom. The DEMo system can illustrate conduction of various materials,…

  5. Versatile Supramolecular Gene Vector Based on Host-Guest Interaction

    NARCIS (Netherlands)

    Liu, Jia; Hennink, Wim E.; Van Steenbergen, Mies J.; Zhuo, Renxi; Jiang, Xulin

    2016-01-01

    It is a great challenge to arrange multiple functional components into one gene vector system to overcome the extra- and intracellular obstacles for gene therapy. In this study, we developed a supramolecular approach for constructing a versatile gene delivery system composed of adamantyl-terminated

  6. Comparison of dioxins and related compounds in the emission during the start-up procedures at a municipal waste incinerator

    Energy Technology Data Exchange (ETDEWEB)

    Gass, H.C.; Suenderhauf, W. [GfA - Gesellschaft fuer Arbeitsplatz und Umweltanalytik mbH, Berlin (Germany); Lueder, K. [MVB Muellverwertung Borsigstrasse GmbH, Hamburg (Germany); Wilken, M. [MWC - Michael Wilken Consulting, Berlin (Germany)

    2004-09-15

    In 2002/2003 we reported about PCDD/F-emissions during the start-up of a municipal waste incinerator. With primary and secondary measures during the optimization of the cold start-up phase we could show a sustainable reduction of the stack gas emissions of PCDD/F down to the range of normal operation even in the start-up phase. The measurement results of chlorophenols (ClP) and chlorobenzenes (ClB) in the flue gas (sampling point ''after boiler'') during cold-start up procedure of selected campaigns will be discussed in this paper.

  7. Start-up of a power unit of a thermal power plant auxiliary system with supply from a hydropower plant

    OpenAIRE

    Zbigniew Lubośny; Krzysztof Dobrzyński; Jacek Klucznik

    2013-01-01

    This article discusses the issues related to a power unit of a thermal power plant start-up with the use of a hydropower plant. Hydropower plant can supply and will enable start-up of auxiliary equipment in a power unit of a thermal power plant. Due to high capacity of auxiliary drives, startup of auxiliaries in a thermal power plant after blackout (and boiler shutdown) is not possible from emergency energy sources in the power plant. In such a case an external electricity source with high ca...

  8. Start-up of a power unit of a thermal power plant auxiliary system with supply from a hydropower plant

    Directory of Open Access Journals (Sweden)

    Zbigniew Lubośny

    2013-09-01

    Full Text Available This article discusses the issues related to a power unit of a thermal power plant start-up with the use of a hydropower plant. Hydropower plant can supply and will enable start-up of auxiliary equipment in a power unit of a thermal power plant. Due to high capacity of auxiliary drives, startup of auxiliaries in a thermal power plant after blackout (and boiler shutdown is not possible from emergency energy sources in the power plant. In such a case an external electricity source with high capacity is required.

  9. AUDIT OF INNOVATIVE IDEAS AS THE PREVIOUS STAGE OF THE BUSINESS-PLAN OF START-UP PROJECTS

    Directory of Open Access Journals (Sweden)

    O. Zhylinska

    2014-09-01

    Full Text Available The phenomenon of feasibility reasoning of venture capital investment for the implementation of innovative ideas is revealed. The main elements of the methodology for feasibility of start-up projects, based on the concept of combination of life cycle of the market, product innovation and startup companies, are characterized. The comparative analysis of methods feasibility study and business plan start-up project is made, the importance of innovative ideas audit in future economic information generation and investment decisions of informal venture capital investors are shown.

  10. Digital computer study of nuclear reactor thermal transients during startup of 60-kWe Brayton power conversion system

    Science.gov (United States)

    Jefferies, K. S.; Tew, R. C.

    1974-01-01

    A digital computer study was made of reactor thermal transients during startup of the Brayton power conversion loop of a 60-kWe reactor Brayton power system. A startup procedure requiring the least Brayton system complication was tried first; this procedure caused violations of design limits on key reactor variables. Several modifications of this procedure were then found which caused no design limit violations. These modifications involved: (1) using a slower rate of increase in gas flow; (2) increasing the initial reactor power level to make the reactor respond faster; and (3) appropriate reactor control drum manipulation during the startup transient.

  11. START-UP FINANCING SOURCES: DOES GENDER MATTER? SOME EVIDENCE FOR EU AND ROMANIA

    Directory of Open Access Journals (Sweden)

    Badulescu Alina

    2011-07-01

    Full Text Available Although financial resources are very important in SMEs in general, and for start-ups in particular, many entrepreneurs face numerous restrictions in finding sources for start-up financing. The present article aims to investigate the similarities or differences in start-up financing sources due to gender issues, otherwise to investigate if female entrepreneurs use (or have access different financial sources in the early stage of their business. As reported by the literature, access to finance is one of the most important issues for SMEs and nascent entrepreneurs. Moreover, among the main financial issues, the first one is the access to start-up finance (Schwartz, 1976; Carter and Cannon, 1992; Johnson and Storey, 1993; Koper, 1993; Van Auken et al, 1993; Carter and Rosa, 1998, FOBS survey 2005. In all sectors, women use for starting up businesses substantially less capital then men. Women encounter, more then men, credibility problems when dealing with bankers. This problem causes important effects concerning the performance, survival and growth of women-run businesses. The present research focuses on revealing how male and female entrepreneurs face and solve the problem of start-up financing sources. The methodology is based on using the dataset "Enterprises managed by the founder - broken down by gender of the entrepreneur", available in EUROSTAT database. The data selected refers to the start-up financing sources available for European Union and Romania, regarding activities included in NACE: Industry and services excluding public administration and management activities of holding companies and 2005 as time of reference. The data were used to make some comparison between: male versus female entrepreneurs in EU; male versus female entrepreneurs in Romania; EU entrepreneurs versus Romanian entrepreneurs. The main findings reveal that there are no significant differences between men and women concerning the start-up financing sources. The main

  12. Monadic Functional Reactive Programming

    NARCIS (Netherlands)

    A.J. van der Ploeg (Atze); C Shan

    2013-01-01

    htmlabstractFunctional Reactive Programming (FRP) is a way to program reactive systems in functional style, eliminating many of the problems that arise from imperative techniques. In this paper, we present an alternative FRP formulation that is based on the notion of a reactive computation: a

  13. Effect of Start-Up Strategies and Electrode Materials on Carbon Dioxide Reduction on Biocathodes.

    Science.gov (United States)

    Saheb-Alam, Soroush; Singh, Abhijeet; Hermansson, Malte; Persson, Frank; Schnürer, Anna; Wilén, Britt-Marie; Modin, Oskar

    2018-02-15

    The enrichment of CO 2 -reducing microbial biocathodes is challenging. Previous research has shown that a promising approach could be to first enrich bioanodes and then lower the potential so the electrodes are converted into biocathodes. However, the effect of such a transition on the microbial community on the electrode has not been studied. The goal of this study was thus to compare the start-up of biocathodes from preenriched anodes with direct start-up from bare electrodes and to investigate changes in microbial community composition. The effect of three electrode materials on the long-term performance of the biocathodes was also investigated. In this study, preenrichment of acetate-oxidizing bioanodes did not facilitate the start-up of biocathodes. It took about 170 days for the preenriched electrodes to generate substantial cathodic current, compared to 83 days for the bare electrodes. Graphite foil and carbon felt cathodes produced higher current at the beginning of the experiment than did graphite rods. However, all electrodes produced similar current densities at the end of the over 1-year-long study (2.5 A/m 2 ). Methane was the only product detected during operation of the biocathodes. Acetate was the only product detected after inhibition of the methanogens. Microbial community analysis showed that Geobacter sp. dominated the bioanodes. On the biocathodes, the Geobacter sp. was succeeded by Methanobacterium spp., which made up more than 80% of the population. After inhibition of the methanogens, Acetobacterium sp. became dominant on the electrodes (40% relative abundance). The results suggested that bioelectrochemically generated H 2 acted as an electron donor for CO 2 reduction. IMPORTANCE In microbial electrochemical systems, living microorganisms function as catalysts for reactions on the anode and/or the cathode. There is a variety of potential applications, ranging from wastewater treatment and biogas generation to production of chemicals. Systems

  14. Strenthening Opportunities Of Economic Relations Between Lithuania And Sweden Within The Perspective Of It Startup Company’s Development

    National Research Council Canada - National Science Library

    Živilė Tunčikienė; Gabrielė Sinkevičiūtė

    2017-01-01

    .... In order to develop and utilize the potential for economic cooperation in the IT field, it is relevant to structuralize IT startup business success factors and to jointly develop base for decisions...

  15. MANAGEMENT PRACTICES THAT COMBINE VALUE COCREATION AND USER EXPERIENCE An Analysis of the Nubank Startup in the Brazilian Market

    National Research Council Canada - National Science Library

    Simone Carvalho da Rosa; Dusan Schreiber; Serje Schmidt; Norberto Kuhn Junior

    2017-01-01

    Taking into account the scenario of economic instability, registered in Brazil in 2016, it was possible to observe sectors that presented growth, especially startups, innovative and disruptive business models. In Fonseca's view (2006...

  16. Environmental versatility promotes modularity in genome-scale metabolic networks.

    Science.gov (United States)

    Samal, Areejit; Wagner, Andreas; Martin, Olivier C

    2011-08-24

    The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new arrangements that may benefit their carrier. Conversely, modularity may emerge as a by-product of some trait. We here ask whether this last scenario may play a role in genome-scale metabolic networks that need to sustain life in one or more chemical environments. For such networks, we define a network module as a maximal set of reactions that are fully coupled, i.e., whose fluxes can only vary in fixed proportions. This definition overcomes limitations of purely graph based analyses of metabolism by exploiting the functional links between reactions. We call a metabolic network viable in a given chemical environment if it can synthesize all of an organism's biomass compounds from nutrients in this environment. An organism's metabolism is highly versatile if it can sustain life in many different chemical environments. We here ask whether versatility affects the modularity of metabolic networks. Using recently developed techniques to randomly sample large numbers of viable metabolic networks from a vast space of metabolic networks, we use flux balance analysis to study in silico metabolic networks that differ in their versatility. We find that highly versatile networks are also highly modular. They contain more modules and more reactions that are organized into modules. Most or all reactions in a module are associated with the same biochemical pathways. Modules that arise in highly versatile networks generally involve reactions that process nutrients or closely related chemicals. We also observe that the metabolism of E. coli is significantly more modular than even our most versatile networks. Our work shows that modularity in metabolic networks can be a by-product of functional constraints, e.g., the need to sustain life in multiple

  17. Environmental versatility promotes modularity in genome-scale metabolic networks

    Science.gov (United States)

    2011-01-01

    Background The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new arrangements that may benefit their carrier. Conversely, modularity may emerge as a by-product of some trait. We here ask whether this last scenario may play a role in genome-scale metabolic networks that need to sustain life in one or more chemical environments. For such networks, we define a network module as a maximal set of reactions that are fully coupled, i.e., whose fluxes can only vary in fixed proportions. This definition overcomes limitations of purely graph based analyses of metabolism by exploiting the functional links between reactions. We call a metabolic network viable in a given chemical environment if it can synthesize all of an organism's biomass compounds from nutrients in this environment. An organism's metabolism is highly versatile if it can sustain life in many different chemical environments. We here ask whether versatility affects the modularity of metabolic networks. Results Using recently developed techniques to randomly sample large numbers of viable metabolic networks from a vast space of metabolic networks, we use flux balance analysis to study in silico metabolic networks that differ in their versatility. We find that highly versatile networks are also highly modular. They contain more modules and more reactions that are organized into modules. Most or all reactions in a module are associated with the same biochemical pathways. Modules that arise in highly versatile networks generally involve reactions that process nutrients or closely related chemicals. We also observe that the metabolism of E. coli is significantly more modular than even our most versatile networks. Conclusions Our work shows that modularity in metabolic networks can be a by-product of functional constraints, e.g., the need to

  18. Environmental versatility promotes modularity in genome-scale metabolic networks

    Directory of Open Access Journals (Sweden)

    Wagner Andreas

    2011-08-01

    Full Text Available Abstract Background The ubiquity of modules in biological networks may result from an evolutionary benefit of a modular organization. For instance, modularity may increase the rate of adaptive evolution, because modules can be easily combined into new arrangements that may benefit their carrier. Conversely, modularity may emerge as a by-product of some trait. We here ask whether this last scenario may play a role in genome-scale metabolic networks that need to sustain life in one or more chemical environments. For such networks, we define a network module as a maximal set of reactions that are fully coupled, i.e., whose fluxes can only vary in fixed proportions. This definition overcomes limitations of purely graph based analyses of metabolism by exploiting the functional links between reactions. We call a metabolic network viable in a given chemical environment if it can synthesize all of an organism's biomass compounds from nutrients in this environment. An organism's metabolism is highly versatile if it can sustain life in many different chemical environments. We here ask whether versatility affects the modularity of metabolic networks. Results Using recently developed techniques to randomly sample large numbers of viable metabolic networks from a vast space of metabolic networks, we use flux balance analysis to study in silico metabolic networks that differ in their versatility. We find that highly versatile networks are also highly modular. They contain more modules and more reactions that are organized into modules. Most or all reactions in a module are associated with the same biochemical pathways. Modules that arise in highly versatile networks generally involve reactions that process nutrients or closely related chemicals. We also observe that the metabolism of E. coli is significantly more modular than even our most versatile networks. Conclusions Our work shows that modularity in metabolic networks can be a by-product of functional

  19. Light water reactor fuel response during reactivity initiated accident experiments

    Energy Technology Data Exchange (ETDEWEB)

    MacDonald, P. E.; McCardell, R. K.; Martinson, Z. R.; Seiffert, S. L.

    1979-01-01

    Experimental results from six recent Power Burst Facility (PBF) reactivity initiated accident (RIA) tests are compared with data from previous Special Power Excursion Reactor Test (SPERT), and Japanese Nuclear Safety Research Reactor (NSRR) tests. The RIA fuel behavior experimental program recently started in the PBF is being conducted with coolant conditions typical of hot-startup conditions in a commercial boiling water reactor. The SPERT and NSRR test programs investigated the behavior of single or small clusters of light water reactor (LWR) type fuel rods under approximate room temperature and atmospheric pressure conditions in capsules containing stagnant water. As observed in the SPERT and NSRR tests, energy deposition, and consequent enthalpy increase in the PBF test fuel, appears to be the single most important variable. However, the consequences of failure at boiling water hot-startup system conditions appear to be more severe than previously observed in either the stagnant capsule SPERT or NSRR tests. Metallographic examination of both previously unirradiated and irradiated PBF fuel rod cross sections revealed extensive variation in cladding wall thicknesses (involving considerable plastic flow) and fuel shattering along grain boundaries in both restructured and unrestructured fuel regions. Oxidation of the cladding resulted in fracture at the location of cladding thinning and disintegration of the rods during quench. In addition,swelling of the gaseous and potentially volatile fission products in previously irradiated fuel resulted in volume increases of up to 180% and blockage of the coolant channels within the flow shrouds surrounding the fuel rods.

  20. Start-up analysis of partial nitrification process in SBR reactors for different initial conditions

    Directory of Open Access Journals (Sweden)

    Iliaszewicz Paula

    2017-01-01

    Full Text Available There are a lot of technical solutions that are designed to improve the efficiency of nitrogen removal from wastewater. One of the most interesting processes are autotrophic nitrogen removal process ANAMMOX. Essential for the ANAMMOX process is prepare the wastewater containing the correct proportion of ammonium and nitrite. The study tested strategies for start-up of the partial nitrification from wastewater streams from sludge dewatering after the methane fermentation process. The start-up was tested for partial nitrification process from full nitrification process in pilot scale. For the initial conditions was developed strategies. In this strategy was chosen initial parameters such as pH, temperature, and DO to the partial nitrification process will be well.

  1. Solid oxide fuel cell power plant having a bootstrap start-up system

    Science.gov (United States)

    Lines, Michael T

    2016-10-04

    The bootstrap start-up system (42) achieves an efficient start-up of the power plant (10) that minimizes formation of soot within a reformed hydrogen rich fuel. A burner (48) receives un-reformed fuel directly from the fuel supply (30) and combusts the fuel to heat cathode air which then heats an electrolyte (24) within the fuel cell (12). A dilute hydrogen forming gas (68) cycles through a sealed heat-cycling loop (66) to transfer heat and generated steam from an anode side (32) of the electrolyte (24) through fuel processing system (36) components (38, 40) and back to an anode flow field (26) until fuel processing system components (38, 40) achieve predetermined optimal temperatures and steam content. Then, the heat-cycling loop (66) is unsealed and the un-reformed fuel is admitted into the fuel processing system (36) and anode flow (26) field to commence ordinary operation of the power plant (10).

  2. Missing links between lean startup, design thinking, and experiential learning approaches in entrepreneurship education

    DEFF Research Database (Denmark)

    Ramsgaard, Michael Breum; Christensen, Marie Ernst

    2016-01-01

    , design thinking, and experiential learning be identified? • How can new concepts of learning models, taking lean startup, design thinking and experiential learning approaches into account, be developed in entrepreneurship education? Approach This 3e conference paper begins as a conceptual paper...... topics through a later case study. The research project will develop empirical qualitative data to further elaborate the discussion. Qualitative interviews with five entrepreneurship educators from three educational institutions will shape the platform for condensation of meaning and new knowledge...... valuable for research in entrepreneurship education. In-depth interviews will provide data to be analyzed in combination with vignette methods that seeks to test the following research question: How do entrepreneurship educators reflect upon the three approaches lean startup, design thinking...

  3. Lean Startup -menetelmien hyödyntäminen matkailuyritystä perustaessa

    OpenAIRE

    Junnonen, Anssi

    2015-01-01

    Tämän toiminnallisen opinnäytetyön aiheena on Lean Startup –menetelmien hyödyntäminen matkailuyritystä perustettaessa. Työn tavoitteena oli luoda matkailuyritykselle sopiva teoriapohja Lean Startup –menetelmistä ja luoda yksinkertainen tuote(MVP) Lean Canvasta käyttäen, jonka avulla voidaan pienellä taloudellisella riskillä testata onko liiketoiminnalle edellytyksiä. Opinnäytetyö sisältää osion jossa esitellään Lean Startupin ominais-piirteitä ja keskeisiä menetelmiä. Työssä käsitellään myös ...

  4. Missing links between lean startup, design thinking, and experiential learning approaches in entrepreneurship education

    DEFF Research Database (Denmark)

    Ramsgaard, Michael Breum; Christensen, Marie Ernst

    2016-01-01

    , design thinking, and experiential learning be identified? • How can new concepts of learning models, taking lean startup, design thinking and experiential learning approaches into account, be developed in entrepreneurship education? Approach This 3e conference paper begins as a conceptual paper...... highlighting the theories and underlying learning models behind three pedagogical approaches within entrepreneurship education, namely lean startup, design thinking and experiential learning. The paper builds this knowledge framework in order to set the design for an empirical investigation of the proposed...... topics through a later case study. The research project will develop empirical qualitative data to further elaborate the discussion. Qualitative interviews with five entrepreneurship educators from three educational institutions will shape the platform for condensation of meaning and new knowledge...

  5. Minimum Viable Product and the Importance of Experimentation in Technology Startups

    Directory of Open Access Journals (Sweden)

    Dobrila Rancic Moogk

    2012-03-01

    Full Text Available Entrepreneurs are often faced with limited resources in their quest to commercialize new technology. This article presents the model of a lean startup, which can be applied to an organization regardless of its size or environment. It also emphasizes the conditions of extreme uncertainty under which the commercialization of new technology is carried out. The lean startup philosophy advocates efficient use of resources by introducing a minimum viable product to the market as soon as possible in order to test its value and the entrepreneur’s growth projections. This testing is done by running experiments that examine the metrics relevant to three distinct types of the growth. These experiments bring about accelerated learning to help reduce the uncertainty that accompanies commercialization projects, thereby bringing the resulting new technology to market faster.

  6. Training Future Entrepreneurs Using European Funds. A Descriptive Research on Start-Up Romania Programs

    Directory of Open Access Journals (Sweden)

    Cristina Nicolau

    2016-01-01

    Full Text Available This paper focuses on the mutual relationship among the concepts of entrepreneurship, trainingpersonnel and business start-up and development. From our point of view, Romania shallencourage as much as possible entrepreneurship so as to create SMEs, the most flexible andnumerous in number in the Romanian total number of companies. Hence, the main objective of thispaper is to highlight the importance of accessing European funds in increasing the number ofRomanians properly trained so as to become successful entrepreneurs and to manage successfulbusinesses. At the same time, another main objective is to present the need of entrepreneurshiptraining and support in business start-up and development by using the descriptive method ofresearch.

  7. Market Segmentation, Customers, and Value Propositions Analysis for Polymer Clay Art Business Start-Up

    Directory of Open Access Journals (Sweden)

    Desman Hidayat

    2016-05-01

    Full Text Available Polymer clay art is one of the creative businesses that are recently starting to get a lot of attentions. To prepare a startup business in this field, analysis from a lot of aspects is needed. The purpose of this article was to explain the approach of the polymer clay art business startup from the market segmentation, customer, and value proposition side of the business. The method was applied by analyzing those steps in details. The analysis started from brainstorming to choose the market matching to business, the customer side, value proposition, and between both aspects. The result of the analysis shows the business focus of the polymer clay art business, where the value propositions are focusing on unique decorations, and several types of customer segments.

  8. Performance evaluation of startup for a yeast membrane bioreactor (MBRy) treating landfill leachate.

    Science.gov (United States)

    Amaral, Míriam C S; Gomes, Rosimeire F; Brasil, Yara L; Oliveira, Sílvia M A; Moravia, Wagner G

    2017-12-06

    The startup process of a membrane bioreactor inoculated with yeast biomass (Saccharomyces cerevisiae) and used in the treatment of landfill leachate was evaluated. The yeast membrane bioreactor (MBRy) was inoculated with an exogenous inoculum, a granulated active dry commercial bakers' yeast. The MBRy was successfully started up with a progressive increase in the landfill leachate percentage in the MBRy feed and the use of Sabouraud Dextrose Broth. The membrane plays an important role in the startup phase because of its full biomass retention and removal of organic matter. MBRy is a suitable and promising process to treat recalcitrant landfill leachate. After the acclimation period, the COD and NH 3 removal efficiency reached values of 72 ± 3% and 39 ± 2% respectively. MBRy shows a low membrane-fouling potential. The membrane fouling was influenced by soluble microbial products, extracellular polymeric substances, sludge particle size, and colloidal dissolved organic carbon.

  9. Von Start-ups lernen - Methoden und Entwicklungsprozesse, die Jungunternehmen erfolgreich machen

    Science.gov (United States)

    Böhme, Eckhart

    Die Start-up-Bewegung bringt beständig sog. Disruptoren hervor, die jede Branche betreffen und so gut wie keinen Lebensbereich auslassen. Diese Jungunternehmen, insbesondere aus der Softwarebranche, verfügen zwar nicht über Ressourcen wie etablierte Unternehmen, sie sind jedoch agil, "hungrig", können frei von "Ballast" agieren und treiben die Digitalisierung aller Branchen voran. Aber auch Start-ups können nicht einfach ungetestete Ideen in erfolgreiche Produkte oder Dienstleistungen umwandeln und ihren Erfolg dem Zufall überlassen. Erfolgreiche Jungunternehmen folgen vielmehr einem strukturierten Prozess, um marktgetestete Nutzenversprechen und Geschäftsmodelle zu entwickeln. Zunehmend adaptieren etablierte Unternehmen innovative Entwicklungsprozesse und Methoden. Die Fragestellung für Energieversorgungsunternehmen (EVUs) lautet, welche Methoden, Werkzeuge und Entwicklungsprozesse, die heute bei vielen Start-ups eingesetzt werden, sie aufgreifen können, um das Unternehmen gegenüber Disruptoren robust zu machen?

  10. Start-up performance of parabolic trough concentrating solar power plants

    DEFF Research Database (Denmark)

    Ferruzza, Davide; Topel, Monika; Basaran, Ibrahim

    2017-01-01

    . In this regard, two of the key components identified are the steam generation system and steam turbine. In general it is desirable to have fast ramp-up rates during the start-up of a power plant. However ramp-up rates are limited by, among other things, thermal stresses, which if high enough can compromise...... the life of the components. Moreover, from an operability perspective it might not be optimal to have designs for the highest heating rates, as there may be other components limiting the power plant start-up. Therefore, it is important to look at the interaction between the steam turbine and steam...... generator to determine the optimal ramp rates. This paper presents a methodology to account for thermal stresses limitations during the power plant start up, aiming at identifying which components limit the ramp rates. A detailed dynamic model of a parabolic trough power plant was developed and integrated...

  11. Life Science Start-up Activities at the Universities of Applied Sciences (UAS).

    Science.gov (United States)

    Huber, Gerda

    2014-12-01

    The universities of applied sciences (UAS) provide several values for the society and economy of a country. Besides education of high level professionals, transfer of knowledge from research to applications in industry or as new start-up companies is an important task. This is done in different ways in the various disciplines. In Life Sciences, a key industry branch in Switzerland, innovation is a competitive success factor and research findings from UAS/Life Sciences contribute to the valorization of new technologies to products, services and to business performance. In order to foster awareness for the innovation need of industry, UAS install processes and support for transfer of research and technology results to marketable applications. Furthermore they may facilitate contacts of researchers and students with entrepreneurs in order to animate start-up founding as a true alternative to being employed. Access to coaching and entrepreneurial training completes the essential basis.

  12. How To Design A Triple Bottom Line Organization: A Start-Up Case Study

    Directory of Open Access Journals (Sweden)

    Bernhard Schroeder

    2014-05-01

    Full Text Available In today’s business environment, where success for a start-up company is measured by early revenue and profit, it can be quite challenging to design a triple bottom line organization (people/planet/profit from the very beginning. We present a case study of a U.S.-based start-up firm and discuss its early challenges, developmental processes, and current success as a triple bottom line firm. The company’s founder and CEO, with no initial product, distribution, or revenue strategy, sought to develop a company that could provide the marketplace with a valuable product while also staying true to a corporate vision of positively affecting less fortunate people. Our analysis of the case suggests that the founder’s vision, passion, transparent communication, and leveraging of partners’ resources were key elements in building the firm. We draw implications of our case study for the designers of future triple bottom line organizations.

  13. Exploring entrepreneurial readiness of youth and startup success components: Entrepreneurship training as a moderator

    Directory of Open Access Journals (Sweden)

    Seun Azeez Olugbola

    2017-09-01

    Full Text Available From the behavioral perspective, this study analyzed the entrepreneurial readiness of youth in terms of opportunity identification, motivational factors, resources, and entrepreneurial ability. The study examined the effect of entrepreneurship training on young people's readiness to engage in entrepreneurial activity and the components behind successful startups. SEM was applied to a sample of 490 students from the Universiti Sains Islam Malaysia. The findings highlight the positive effect of opportunity identification, motivation, and resources on entrepreneurship and the central role of entrepreneurship training in all factors, including entrepreneurial ability. The role of entrepreneurship training implies that young individuals are able to develop their entrepreneurial ability. The study thus shows the individual's ability to change over the course of a lifetime. For individuals interested in the startup process, this study provides information capable of influencing their new business ventures.

  14. Startup of pilot-scale aerobic granular sludge reactor by stored granules.

    Science.gov (United States)

    Liu, Q S; Liu, Y; Tay, S T L; Show, K Y; Ivanov, V; Benjamin, M; Tay, J H

    2005-12-01

    The startup of a pilot-scale aerobic granular sludge reactor was investigated by seeding with 4-month stored aerobic granules. Two liters of granules were inoculated into the reactor (5.9% of reactor volume), which gave a biomass concentration of 1.03 g l(-1). Experimental results showed that seeding granules could be successfully maintained in the reactor. The microbial activity of seeding granules could be fully recovered to that of fresh granules after 2 days of operation, and new granules started to grow after day 5. Newly developed aerobic granules at stable period had similar size and morphology as seeding granules, and a biomass concentration of 6.0 g l(-1) was achieved in the reactor. The experiment demonstrated for the first time that stored aerobic granules could be used for easy and quick startup of aerobic granular sludge reactor.

  15. The optimal control in batch arrival queue with server vacations, startup and breakdowns

    Directory of Open Access Journals (Sweden)

    Ke Jau-Chuan

    2004-01-01

    Full Text Available This paper studies the N policy M[x]/G/1 queue with server vacations; startup and breakdowns, where arrivals form a compound Poisson process and service times are generally distributed. The server is turned off and takes a vacation whenever the system is empty. If the number of customers waiting in the system at the instant of a vacation completion is less than N, the server will take another vacation. If the server returns from a vacation and finds at least N customers in the system, he is immediately turned on and requires a startup time before providing the service until the system is empty again. It is assumed that the server breaks down according to a Poisson process whose repair time has a general distribution. The system characteristics of such a model are analyzed and the total expected cost function per unit time is developed to determine the optimal threshold of N at a minimum cost.

  16. A study of technological capability among product based telecom start-ups in India: Role of knowledge, learning and bricolage

    OpenAIRE

    Aeron, Prageet; Jain, Rekha

    2015-01-01

    Present work explores the development of new products among telecom start-ups in India. This paper weaves together threads of literature including innovation, bricolage, learning and knowledge acquisition and technological capability. We employ a qualitative research method and works through the data collected from seven independent start-ups. Our work proposes a process model for the evolution of technological capability as a result of complex interplay between existing knowledge, bricolage,...

  17. Planning and management of E-commerce Website : Guide for startup B2C E-commerce companies

    OpenAIRE

    Wang, Ying

    2016-01-01

    The purpose of this thesis is to help startup B2C E-commerce companies to plan and manage e-commerce website. This thesis is intended to equip current and future e-commerce managers or entrepreneurs with some basic knowledge and practical skills to help them navigate their organisations towards e-business. It does not have any specific commissioner. Thesis will contain most aspects when plan and manage e-commerce website for startups.

  18. Emissions of polychlorinated diphenyl ethers from a municipal solid waste incinerator during the start-up operation

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Jing-Sing [Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan (China); Lin, Sheng-Lun, E-mail: cbmsgml@gmail.com [Department of Civil Engineering and Geomatics, Cheng Shiu University, Kaohsiung 83347, Taiwan (China); Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan (China); Lin, Ta-Chang; Wu, Yee-Lin [Department of Environmental Engineering, National Cheng Kung University, Tainan 70101, Taiwan (China); Wang, Lin-Chi [Department of Civil Engineering and Geomatics, Cheng Shiu University, Kaohsiung 83347, Taiwan (China); Chang-Chien, Guo-Ping, E-mail: guoping@csu.edu.tw [Super Micro Mass Research and Technology Center, Cheng Shiu University, Kaohsiung 83347, Taiwan (China); Department of Cosmetic and Fashion Styling, Kaohsiung 83347, Taiwan (China)

    2015-12-15

    Highlights: • This is the first study on the PCDE emission during a MSWI start-up procedure. • The highest PCDE level occurred similar to the PCDD/F reformation temperature. • The pollution control were modified and reduce 86% PCDE peak emission. • Multiple start-ups are analyzed for their effects on the annual PCDE emission. - Abstract: This study examines the emissions of polychlorinated diphenyl ethers (PCDEs) during the start-up processes of a municipal solid waste incinerator (MSWI). Both normal and modified emission control start-ups were tested. Fifteen samples were taken from the flue gas with increasing furnace temperature. Peak PCDE concentrations of 1.48–10.3 ng/Nm{sup 3} were observed at 8–11 h after the start of combustion, when the furnace temperature was in the range of 267–440 °C, that also needed for PCDD/F formation by de novo synthesis. The PCDE emissions could thus, be reduced by current control techniques. Furthermore, the modified control strategies inhibited PCDE formation at the beginning of combustion, and led to an 86% reduction in the maximum PCDE concentration. The overall start-up emissions were calculated as 1.01–3.08 mg, while the annual PCDE emissions with one start-up operation were found to be 7.48–9.64 mg. However, total PCDE emissions will increase by 12–69% if the number of start-up runs increases to between two and eight times per year. Consequently, the prevention of the unnecessary start-ups and advanced activation of the related emission control system are both efficient ways to reduce PCDE emissions.

  19. Start-Up of an Anaerobic Dynamic Membrane Digester for Waste Activated Sludge Digestion: Temporal Variations in Microbial Communities

    OpenAIRE

    Yu, Hongguang; Wang, Qiaoying; Wang, Zhiwei; Sahinkaya, Erkan; Li, Yongli; Ma, Jinxing; Wu, Zhichao

    2014-01-01

    An anaerobic dynamic membrane digester (ADMD) was developed to digest waste sludge, and pyrosequencing was used to analyze the variations of the bacterial and archaeal communities during the start-up. Results showed that bacterial community richness decreased and then increased over time, while bacterial diversity remained almost the same during the start-up. Proteobacteria and Bacteroidetes were the major phyla. At the class level, Betaproteobacteria was the most abundant at the end of start...

  20. Perceived financial barriers and the start-up decision: An econometric analysis of gender differences using GEM data

    OpenAIRE

    Roper, Stephen; Scott, Jonathan

    2009-01-01

    Although accessing finance is key to the foundation of any business, particular concerns have been expressed about the ability of UK women-owned firms to obtain external finance. In this paper we use an econometric approach to explore the effect of perceptions of financial barriers to start-up on the start-up decision itself. Our analysis is based on the Global Entrepreneurship Monitor (GEM) UK 2004 database. Standardising for a range of individual characteristics, we find that women are arou...

  1. Informal Networks and Start-Up Entrepreneurs in Spain: Networking Other Entrepreneurs and Angel Investors

    OpenAIRE

    Aliaga Isla, Rocio

    2014-01-01

    This paper contributes by containing an examination of the impact of informal networks, such as personally knowing other entrepreneurs and having access to business angel investors, have upon start-up entrepreneurs in Spain. In addition, a pseudo-panel approach is used with micro data from the Spanish Global Entrepreneurship Monitor (GEM) adult population survey over the period 2006-2009. This technique overcomes limitations found when using cross-sectional data. Moreover, this includes a sho...

  2. ENTREPRENEURIAL FINANCE: ANGEL INVESTING AS A SOURCE OF FUNDING HIGH-GROWTH START-UP FIRMS

    Directory of Open Access Journals (Sweden)

    SONJA MARKOVA

    2010-01-01

    Full Text Available One of the most difficult components in starting and growing a new venture is securing funding and other resources to sustain the firm’s survival and growth. Funding for many new ventures comes from a large, yet relatively unidentified, group called angel investors. This paper provides an overview of angel investing as a source of funding for start-up firms.

  3. Assessment of Startup Fuel Options for a Test or Demonstration Fast Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Carmack, Jon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hayes, Steven [Idaho National Lab. (INL), Idaho Falls, ID (United States); Walters, L. C. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    This document explores startup fuel options for a proposed test/demonstration fast reactor. The fuel options considered are the metallic fuels U-Zr and U-Pu-Zr and the ceramic fuels UO2 and UO2-PuO2 (MOX). Attributes of the candidate fuel choices considered were feedstock availability, fabrication feasibility, rough order of magnitude cost and schedule, and the existing irradiation performance database. The reactor-grade plutonium bearing fuels (U-Pu-Zr and MOX) were eliminated from consideration as the initial startup fuels because the availability and isotopics of domestic plutonium feedstock is uncertain. There are international sources of reactor grade plutonium feedstock but isotopics and availability are also uncertain. Weapons grade plutonium is the only possible source of Pu feedstock in sufficient quantities needed to fuel a startup core. Currently, the available U.S. source of (excess) weapons-grade plutonium is designated for irradiation in commercial light water reactors (LWR) to a level that would preclude diversion. Weapons-grade plutonium also contains a significant concentration of gallium. Gallium presents a potential issue for both the fabrication of MOX fuel as well as possible performance issues for metallic fuel. Also, the construction of a fuel fabrication line for plutonium fuels, with or without a line to remove gallium, is expected to be considerably more expensive than for uranium fuels. In the case of U-Pu-Zr, a relatively small number of fuel pins have been irradiated to high burnup, and in no case has a full assembly been irradiated to high burnup without disassembly and re-constitution. For MOX fuel, the irradiation database from the Fast Flux Test Facility (FFTF) is extensive. If a significant source of either weapons-grade or reactor-grade Pu became available (i.e., from an international source), a startup core based on Pu could be reconsidered.

  4. Charter Schools: Guidance Needed for Military Base Schools on Startup and Operational Issues

    Science.gov (United States)

    2013-02-01

    losses resulting from federal activities and to help students connected with these federal activities —which may include military- connected students...to the school on weekends, which would prevent the school from holding extracurricular activities , such as morning tutorials or enrichment programs...Schools on Startup and Operational Issues Why GAO Did This Study Many families struggle to balance their job demands with ensuring that their

  5. Preheating of fluid in a supercritical Brayton cycle power generation system at cold startup

    Science.gov (United States)

    Wright, Steven A.; Fuller, Robert L.

    2016-07-12

    Various technologies pertaining to causing fluid in a supercritical Brayton cycle power generation system to flow in a desired direction at cold startup of the system are described herein. A sensor is positioned at an inlet of a turbine, wherein the sensor is configured to output sensed temperatures of fluid at the inlet of the turbine. If the sensed temperature surpasses a predefined threshold, at least one operating parameter of the power generation system is altered.

  6. Strain hardening in startup shear of long-chain branched polymer solutions.

    Science.gov (United States)

    Liu, Gengxin; Cheng, Shiwang; Lee, Hyojoon; Ma, Hongwei; Xu, Hongde; Chang, Taihyun; Quirk, Roderic P; Wang, Shi-Qing

    2013-08-09

    We show for the first time that entangled polymeric liquids containing long-chain branching can exhibit strain hardening upon startup shear. As the significant long-chain branching impedes chain disentanglement, Gaussian coils between entanglements can deform to reach the finite extensibility limit where the intrachain retraction force exceeds the value expected from the usual conformational entropy loss evaluated based on Gaussian chain statistics. The phenomenon is expected to lead to further theoretical understanding.

  7. Effectuation and the influence of social networks on the internationalization of accelerated startups

    OpenAIRE

    Sarmento, Carolaine Fabricia Bonk; Carvalho, Carlos Augusto Septimio de; Dib, Luis Antonio da Rocha

    2016-01-01

    Accelerators recently became a more active alternative to incubators as a mechanism for supporting and developing technology-based startups, especially in their internationalization. At the same time, social networks enable and increase the speed of the process of small firms' internationalization by allowing the attainment of third-party resources and market knowledge. The objective of this research was to better understand how accelerators speed up the process of internationalization for in...

  8. Start-up performance of parabolic trough concentrating solar power plants

    Science.gov (United States)

    Ferruzza, Davide; Topel, Monika; Basaran, Ibrahim; Laumert, Björn; Haglind, Fredrik

    2017-06-01

    Concentrating solar power plants, even though they can be integrated with thermal energy storage, are still subjected to cyclic start-up and shut-downs. As a consequence, in order to maximize their profitability and performance, the flexibility with respect to transient operations is essential. In this regard, two of the key components identified are the steam generation system and steam turbine. In general it is desirable to have fast ramp-up rates during the start-up of a power plant. However ramp-up rates are limited by, among other things, thermal stresses, which if high enough can compromise the life of the components. Moreover, from an operability perspective it might not be optimal to have designs for the highest heating rates, as there may be other components limiting the power plant start-up. Therefore, it is important to look at the interaction between the steam turbine and steam generator to determine the optimal ramp rates. This paper presents a methodology to account for thermal stresses limitations during the power plant start up, aiming at identifying which components limit the ramp rates. A detailed dynamic model of a parabolic trough power plant was developed and integrated with a control strategy to account for the start-up limitations of both the turbine and steam generator. The models have been introduced in an existing techno-economic tool developed by the authors (DYESOPT). The results indicated that for each application, an optimal heating rates range can be identified. For the specific case presented in the paper, an optimal range of 7-10 K/min of evaporator heating rate can result in a 1.7-2.1% increase in electricity production compared to a slower component (4 K/min).

  9. Optimizing social media channels for B2B startups : Case of Odd Expert Oy

    OpenAIRE

    Nguyen, Thi Ngoc Anh

    2016-01-01

    In recent years, the dramatic development of social media and its huge advances on global businesses cannot be deniable. With a large user base and useful analytics support, it helps many companies, especially startups, to reach their target audiences. Additionally, it requires low budget on advertising which stimulates all kinds of businesses to utilize social media channels. This thesis analyzes the effectiveness of social media marketing from perspectives of business-to-business (B2B) ...

  10. Experience from start-ups of the first ANITA Mox plants.

    Science.gov (United States)

    Christensson, M; Ekström, S; Andersson Chan, A; Le Vaillant, E; Lemaire, R

    2013-01-01

    ANITA™ Mox is a new one-stage deammonification Moving-Bed Biofilm Reactor (MBBR) developed for partial nitrification to nitrite and autotrophic N-removal from N-rich effluents. This deammonification process offers many advantages such as dramatically reduced oxygen requirements, no chemical oxygen demand requirement, lower sludge production, no pre-treatment or requirement of chemicals and thereby being an energy and cost efficient nitrogen removal process. An innovative seeding strategy, the 'BioFarm concept', has been developed in order to decrease the start-up time of new ANITA Mox installations. New ANITA Mox installations are started with typically 3-15% of the added carriers being from the 'BioFarm', with already established anammox biofilm, the rest being new carriers. The first ANITA Mox plant, started up in 2010 at Sjölunda wastewater treatment plant (WWTP) in Malmö, Sweden, proved this seeding concept, reaching an ammonium removal rate of 1.2 kgN/m³ d and approximately 90% ammonia removal within 4 months from start-up. This first ANITA Mox plant is also the BioFarm used for forthcoming installations. Typical features of this first installation were low energy consumption, 1.5 kW/NH4-N-removed, low N₂O emissions, started up at Sundets WWTP in Växjö, Sweden, reached full capacity with more than 90% ammonia removal within 2 months from start-up. By applying a nitrogen loading strategy to the reactor that matches the capacity of the seeding carriers, more than 80% nitrogen removal could be obtained throughout the start-up period.

  11. NTN Swiss Biotech - A Look at Support Measures for Dynamic Start-ups.

    Science.gov (United States)

    Heinzelmann, Elsbeth

    2016-01-01

    The Swiss biotech landscape seems to be on a healthy footing: There are many imaginative start-ups, we have first-class hospitals, highly advanced clinical research and the availability of a great deal of capital. But we have no reason to rest on our laurels as countries like the USA lead the field. We must lay down the tracks today to remain an attractive country and maintain our ranking among the 10 best locations.

  12. Partnering with the NIH: Now part of the “Value Proposition” for start-ups

    Science.gov (United States)

    Ferguson, Steven M.

    2012-01-01

    With its “value proposition” statement a start-up company needs to convince potential investors or pharma partners how it will add more value or solve a problem better than others. High value, low cost assets such as those from the NIH ranging from technology to funding to assistance provide such biomedical firms an excellent jump-start in reaching their goals. PMID:23476116

  13. Public policy for start-up entrepreneurship with venture capital and bank finance

    DEFF Research Database (Denmark)

    Keuschnigg, Christian; Nielsen, Søren Bo

    2003-01-01

    This paper proposes and analyses a model of start-up investment. Innovative entrepreneursare commercially inexperienced and can benefit from venture capital support. Only part ofthem succeed in matching with a venture capitalist while the rest must resort to standard bankfinance. We consider...... a number of policies to promote entrepreneurship and venture capitalbacked innovation.JEL Classification: D82, G24, G28, H24.Keywords: venture capital bank finance, matching, moral hazard, public policy....

  14. Strenthening Opportunities of Economic Relations between Lithuania and Sweden within the Perspective of IT Startup Company’s Development

    Directory of Open Access Journals (Sweden)

    Živilė Tunčikienė

    2017-06-01

    Full Text Available Cooperation with Sweden – one of the key priorities of Lithuania. Economic cooperation potential is promising. One of the priority areas of economic activity, in which Sweden invests in Lithuania, is information and communication. In order to develop and utilize the potential for economic cooperation in the IT field, it is relevant to structuralize IT startup business success factors and to jointly develop base for decisions, execution of which would help ensure effective, economic co-operation development based with Sweden, beginning of IT startup business and such business’s continuity. To achieve the objective, following tasks were resolved: concepts of startup business and the startup company were purified, specifics inconcept’s application in the context of the parties were defined; systematized the startup business success factors and ways of strengthening them, focusing on the factors relevant for strengthening economic ties between Lithuania and Sweden within the perspective of IT startup company’s development. Systematic method of research was applied.

  15. Effect of the Modification of the Start-Up Sequence on the Thermal Stresses for a Microgas Turbine

    Directory of Open Access Journals (Sweden)

    Oscar Tenango-Pirin

    2016-01-01

    Full Text Available Microgas turbines (MGT are an alternative for small-scale energy production; however, their small size becomes a drawback since it enhances the heat transfer among their components. Moreover, heat transfer drives to temperature gradients which become higher during transient cycles like start-up. The influence of different start-up curves on temperature and thermal stresses of a microgas turbine was investigated. Stationary and rotational blades of the turbine were numerically simulated using CFD and FEM commercial codes. Conjugated heat transfer cases were solved for obtaining heat transfer from fluid toward the blades. Changes of temperature gradients within the blades during the start-ups were calculated under transient state with boundary conditions according to each curve to assess accurate thermal stresses calculations. Results showed that the modification of the start-up curves had an impact on the thermal stresses levels and on the time when highest stresses appeared on each component. Furthermore, zones highly stressed were located near the constraints of blades where thermal strains are restricted. It was also found that the curve that had a warming period at the beginning of the start-up allowed reducing the peaks of stresses making it more feasible and safer for the turbine start-up operation.

  16. Effects of Gravity on Start-up of a Miniature Loop Heat Pipe with Multiple Evaporators and Multiple Condensers

    Science.gov (United States)

    Ku, Jentung; Nagano, Hosei

    2007-01-01

    This paper describes an experimental study on the effect of gravity on the start-up of a miniature loop heat pipe (MLHP) with two evaporators and two condensers. Each evaporator has an outer diameter of 9 mm and has its own integral compensation chamber (CC). The MLHP was placed under five configurations where the relative elevation and tilt among the loop components were varied. The four well-known initial conditions between the evaporator and CC prior to the LHP start-up were created in this experimental study through combinations of: 1) the test configuration; 2) the method of preconditioning the loop prior to start-up, and 3) the heat load distribution among the evaporators. A total of 165 start-ups were conducted under the five test configurations. All of these start-ups were successful. However, the effect of gravity on start-up transients was clearly seen under otherwise the same heat load distribution and sink temperatures. An analytical model was used to simulate the MLHP transient behaviors, and the model predictions agreed very well with the experimental results.

  17. Emissions of polychlorinated diphenyl ethers from a municipal solid waste incinerator during the start-up operation.

    Science.gov (United States)

    Yang, Jing-Sing; Lin, Sheng-Lun; Lin, Ta-Chang; Wu, Yee-Lin; Wang, Lin-Chi; Chang-Chien, Guo-Ping

    2015-12-15

    This study examines the emissions of polychlorinated diphenyl ethers (PCDEs) during the start-up processes of a municipal solid waste incinerator (MSWI). Both normal and modified emission control start-ups were tested. Fifteen samples were taken from the flue gas with increasing furnace temperature. Peak PCDE concentrations of 1.48-10.3 ng/Nm(3) were observed at 8-11 h after the start of combustion, when the furnace temperature was in the range of 267-440 °C, that also needed for PCDD/F formation by de novo synthesis. The PCDE emissions could thus, be reduced by current control techniques. Furthermore, the modified control strategies inhibited PCDE formation at the beginning of combustion, and led to an 86% reduction in the maximum PCDE concentration. The overall start-up emissions were calculated as 1.01-3.08 mg, while the annual PCDE emissions with one start-up operation were found to be 7.48-9.64 mg. However, total PCDE emissions will increase by 12-69% if the number of start-up runs increases to between two and eight times per year. Consequently, the prevention of the unnecessary start-ups and advanced activation of the related emission control system are both efficient ways to reduce PCDE emissions. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Versatile module for experiments with focussing neutron guides

    Energy Technology Data Exchange (ETDEWEB)

    Adams, T.; Pfleiderer, C.; Böni, P. [Physik-Department, Technische Universität München, D-85748 Garching (Germany); Brandl, G.; Chacon, A.; Wagner, J. N.; Rahn, M.; Mühlbauer, S.; Georgii, R. [Physik-Department, Technische Universität München, D-85748 Garching (Germany); Heinz Maier-Leibnitz Zentrum, FRM II, Technische Universität München, D-85748 Garching (Germany)

    2014-09-22

    We report the development of a versatile module that permits fast and reliable use of focussing neutron guides under varying scattering angles. A simple procedure for setting up the module and neutron guides is illustrated by typical intensity patterns to highlight operational aspects as well as typical parasitic artefacts. Combining a high-precision alignment table with separate housings for the neutron guides on kinematic mounts, the change-over between neutron guides with different focussing characteristics requires no readjustments of the experimental setup. Exploiting substantial gain factors, we demonstrate the performance of this versatile neutron scattering module in a study of the effects of uniaxial stress on the domain populations in the transverse spin density wave phase of single crystal Cr.

  19. Research and development of a versatile portable speech prosthesis

    Science.gov (United States)

    1981-01-01

    The Versatile Portable Speech Prosthesis (VPSP), a synthetic speech output communication aid for non-speaking people is described. It was intended initially for severely physically limited people with cerebral palsy who are in electric wheelchairs. Hence, it was designed to be placed on a wheelchair and powered from a wheelchair battery. It can easily be separated from the wheelchair. The VPSP is versatile because it is designed to accept any means of single switch, multiple switch, or keyboard control which physically limited people have the ability to use. It is portable because it is mounted on and can go with the electric wheelchair. It is a speech prosthesis, obviously, because it speaks with a synthetic voice for people unable to speak with their own voices. Both hardware and software are described.

  20. Examination of microbial fuel cell start-up times with domestic wastewater and additional amendments

    KAUST Repository

    Liu, Guangli

    2011-08-01

    Rapid startup of microbial fuel cells (MFCs) and other bioreactors is desirable when treating wastewaters. The startup time with unamended wastewater (118h) was similar to that obtained by adding acetate or fumarate (110-115h), and less than that with glucose (181h) or Fe(III) (353h). Initial current production took longer when phosphate buffer was added, with startup times increasing with concentration from 149h (25mM) to 251h (50mM) and 526h (100mM). Microbial communities that developed in the reactors contained Betaproteobacteria, Acetoanaerobium noterae, and Chlorobium sp. Anode biomass densities ranged from 200 to 600μg/cm2 for all amendments except Fe(Sh{cyrillic}) (1650μg/cm2). Wastewater produced 91mW/m2, with the other MFCs producing 50mW/m2 (fumarate) to 103mW/m2 (Fe(III)) when amendments were removed. These experiments show that wastewater alone is sufficient to acclimate the reactor without the need for additional chemical amendments. © 2011 Elsevier Ltd.

  1. On a difficulty in eigenfunction expansion solutions for the start-up of fluid flow

    Science.gov (United States)

    Christov, Ivan C.

    2015-11-01

    Most mathematics and engineering textbooks describe the process of ``subtracting off'' the steady state of a linear parabolic partial differential equation as a technique for obtaining a boundary-value problem with homogeneous boundary conditions that can be solved by separation of variables (i.e., eigenfunction expansions). While this method produces the correct solution for the start-up of the flow of, e.g., a Newtonian fluid between parallel plates, it can lead to erroneous solutions to the corresponding problem for a class of non-Newtonian fluids. We show that the reason for this is the non-rigorous enforcement of the start-up condition in the textbook approach, which leads to a violation of the principle of causality. Nevertheless, these boundary-value problems can be solved correctly using eigenfunction expansions, and we present the formulation that makes this possible (in essence, an application of Duhamel's principle). The solutions obtained by this new approach are shown to agree identically with those obtained by using the Laplace transform in time only, a technique that enforces the proper start-up condition implicitly (hence, the same error cannot be committed). Supported, in part, by NSF Grant DMS-1104047 and the U.S. DOE (Contract No. DE-AC52-06NA25396) through the LANL/LDRD Program.

  2. Start-up and incremental practice expenses for behavior change interventions in primary care.

    Science.gov (United States)

    Dodoo, Martey S; Krist, Alex H; Cifuentes, Maribel; Green, Larry A

    2008-11-01

    If behavior-change services are to be offered routinely in primary care practices, providers must be appropriately compensated. Estimating what is spent by practices in providing such services is a critical component of establishing appropriate payment and was the objective of this study. In-practice expenditure data were collected for ten different interventions, using a standardized instrument in 29 practices nested in ten practice-based research networks across the U.S. during 2006-2007. The data were analyzed using standard templates to create credible estimates of the expenses incurred for both the start-up period and the implementation phase of the interventions. Average monthly start-up expenses were $1860 per practice (SE=$455). Most start-up expenditures were for staff training. Average monthly incremental costs were $58 ($15 for provision of direct care [SE=$5]; $43 in overhead [SE=$17]) per patient participant. The bulk of the intervention expenditures was spent on the recruitment and screening of patient participants. Primary care practices must spend money to address their patients' unhealthy behaviors--at least $1860 to initiate systematic approaches and $58 monthly per participating patient to implement the approaches routinely. Until primary care payment systems incorporate these expenses, it is unlikely that these services will be readily available.

  3. Start-Up and Transient Flow Effects From the Molecular Weight Distribution

    Science.gov (United States)

    Borg, Tommi; Pääkkönen, Esko J.

    2008-07-01

    Start-up and transient shear-stress flows are modeled here using the recently generated constitutive model for linear viscoelasticity of polymers. The relation derived from control theory and the melt calibration procedure has been developed between the relaxation modulus, dynamic viscosity, and molecular-weight distribution (MWD). This study extends the start-up, and transient effects of linear viscoelasticity on stress and viscosity from the novel viewpoint of the classical Boltzmann superposition principle. The shear viscosity measurements of well-characterized classical low-density polyethylene (LDPE IUPAC A) with a known MWD were used to obtain time-dependent stress and viscosity transitions. The developed formulas model the start-up situation with an overshoot effect and shear-stress growth coefficient. Simulations were performed for relaxation modulus measurements at different shear histories defined by the effective viscosity. As an example of practical application, injection molding for producing a cellular-phone cover were modeled to obtain the pressure loss and orientation level for every element in finite element models, which predicted the shrinking and warping of the end products.

  4. Effects of Feedstock Sources on Inoculant Acclimatization: Start-up Strategies and Reactor Performance.

    Science.gov (United States)

    Yang, Qian; Wei, Liang-Huan; Li, Wei-Zun; Chen, Yu; Ju, Mei-Ting

    2017-11-01

    Different inoculum sources and acclimatization methods result in different substrate adaptation and biodegradability. To increase straw degradation rate, shorten the digester start-up time, and enhance the biogas production, we domesticated anaerobic sludge by adding microcrystalline cellulose (MCC). During acclimatization, the start-up strategies and reactor performance were investigated to analyze changes in feedstock adaption, biodegradability, and methanogen activity. The effect of the domesticated inoculum was evaluated by testing batch un-pretreated corn stover with a dewatered sludge (DS)-domesticated inoculum as a control. The results showed that (1) using MCC as a substrate rapidly improved microorganism biodegradability and adaptation. (2) MCC as domesticated substrate has relatively stable system and high mass conversion, but with low buffer capacity. (3) Macro- and micronutrients should be added for improving the activity of methanogenic and system's buffer capacity. (4) Using the domesticated inoculums and batch tests to anaerobically digest untreated corn stover yielded rapid biogas production of 292 mL, with an early peak value on the first day. The results indicated that cultivating directional inoculum can efficiently and quickly start-up digester. These investigated results to promote anaerobic digestion of straw for producing biogas speed up the transformation of achievements of biomass solid waste utilization have a positive promoting significance.

  5. Entrepreneurism from the ground up: Entrepreneurism, innovation, and responsiveness in a start-up university

    Science.gov (United States)

    Wong, Michael Paul Anthony

    Colleges and universities are under increased pressure from internal and external constituencies for increased innovation and responsiveness. Entrepreneurial private industry models such as start-up businesses, corporate ventures and spin-off organizations have been recognized for their ability to quickly adapt to changing business environments and rapidly innovate to take advantage of new opportunities. This case study investigates these claims with regard to a start-up university founded with the identity of an entrepreneurial, interdisciplinary institution that prepares graduate level students for leadership careers as entrepreneurs in the bio-tech industry. By interviewing twenty-four administrators, faculty, and members of the Board of Trustees, including all but one of the founding full-time faculty, I present an "insider's" depiction of the lived experience of those most closely associated with the founding and subsequent institution building of this unique higher education organization. Initial chapters present a theory of higher education organizations, derived from Birnbaum (1988) and Bolman and Deal (1991), as driven by two primary tasks: resolving identity and establishing power and resources in relation to that identity. I also present Russell and Russell's (1992) theory of "entrepreneurial posture" in relation to a higher education organization. Subsequent chapters analyze the start-up university's environment, strategy, culture, and structure within the framework of the two primary organizational tasks and Russell and Russell's (1992) definition of an entrepreneurial organization.

  6. Analysis of Three Actors: Roles of Government, Private Sector, and University toward Startup Growth in Yogyakarta

    Directory of Open Access Journals (Sweden)

    Cinintya Audori Fathin

    2016-05-01

    Full Text Available Information, communication, and technology advancements in 21st century encourage startups to innovate and develop their business further. Because it’s an ICT based business which is supported by the existence of internet, this kind of business starts to become borderless. As a result, the distributions of the products start to become unlimited. The conveniences offered by these advancements invite more ICT based product developers. The positive impact as a result of that such as more new jobs, easier way to access the markets, and also cheaper production cost with guaranteed profits. In addition to that, this of course also becomes an added value to the country because it increases Network Readiness Index and nation’s income from taxes. This research aims to analyze startup’s growth, in addition to its relation with related actors such as government, private sectors, and universities. Analysis on every actor will emphasize on their contribution to startup developments in Daerah Istimewa Yogyakarta directly or indirectly. In conclusion, there will be an illustration about how big the contributions and how close the actors are between startups and the three actors.

  7. Start-Up Scenario in Gyrotrons with a Nonstationary Microwave-Field Structure

    Science.gov (United States)

    Nusinovich, G. S.; Yeddulla, M.; Antonsen, T. M., Jr.; Vlasov, A. N.

    2006-03-01

    Megawatt class gyrotrons operate in very high-order modes. Therefore, control of a gyrotron oscillator’s start-up is important for excitation of the desired mode in the presence of the many undesired modes. Analysis of such scenario using the self-consistent code MAGY [M. Botton , IEEE Trans. Plasma Sci. 26,ITPSBD0093-3813 882 (1998)10.1109/27.700860] reveals that during start-up not only mode amplitudes vary in time, but also their axial structure can be time dependent. Simulations done for a 1.5 MW gyrotron show that the excitation of a single operating TE22,6 mode can exhibit a sort of intermittency when, first, it is excited as a mode whose axial structure extends outside the interaction cavity, then it ceases and then reappears as a mode mostly localized in the cavity. This phenomenon makes it necessary to analyze start-up scenarios in such gyrotrons with the use of codes that account for the possible evolution of field profiles.

  8. Modeling the Financial Distress of Microenterprise StartUps Using Support Vector Machines: A Case Study

    Directory of Open Access Journals (Sweden)

    Antonio Blanco-Oliver

    2014-10-01

    Full Text Available Despite the leading role that micro-entrepreneurship plays in economic development, and the high failure rate of microenterprise start-ups in their early years, very few studies have designed financial distress models to detect the financial problems of micro-entrepreneurs. Moreover, due to a lack of research, nothing is known about whether non-financial information and nonparametric statistical techniques improve the predictive capacity of these models. Therefore, this paper provides an innovative financial distress model specifically designed for microenterprise startups via support vector machines (SVMs that employs financial, non-financial, and macroeconomic variables. Based on a sample of almost 5,500 micro- entrepreneurs from a Peruvian Microfinance Institution (MFI, our findings show that the introduction of non-financial information related to the zone in which the entrepreneurs live and situate their business, the duration of the MFI-entrepreneur relationship, the number of loans granted by the MFI in the last year, the loan destination, and the opinion of experts on the probability that microenterprise start-ups may experience financial problems, significantly increases the accuracy performance of our financial distress model. Furthermore, the results reveal that the models that use SVMs outperform those which employ traditional logistic regression (LR analysis.

  9. Physical startup tests for VVER-1200 of Novovoronezh NPP. Advanced technique and some results

    Energy Technology Data Exchange (ETDEWEB)

    Afanasiev, Dmitry A.; Kraynov, Yury A.; Pinegin, Anatoly A.; Tsyganov, Sergey V. [National Research Centre, Moscow (Russian Federation). Kurchatov Inst.

    2017-09-15

    The intention of the startup physics tests was to confirm design characteristics of the core loading and their compliance with safety analysis preconditions. The program of startup tests for the leading unit is usually composed in such a way that is is possible to study as much neutron-physical characteristics as possible in the safest condition of zero power. State-of-the-art safety analysis is including computer codes that use three dimensional neutron kinetics and thermohydraulics models. For the substantiation of such models, for its validation and verification there is a need in reactor experiments that implementing spatially distributed transients. We based on such statements when composing hot zero power physical startup program for the new VVER-1200 unit of Novovoronezh NPP. Several tests unconventional for VVER were developed for that program. It includes measuring the worth for each of control rod groups and measuring of single rod worth from the inserted groups - test that models rod ejection event in some sense.

  10. Using Social Media to Accelerate the Internationalization of Startups from Inception

    Directory of Open Access Journals (Sweden)

    Tony Maltby

    2012-10-01

    Full Text Available A set of principles, processes, and tools that entrepreneurs can use to rapidly internationalize their technology startups from inception does not exist. This article discusses entrepreneurs’ use of online social media networks to rapidly internationalize their startups from inception. The article was inspired by how the founders of Dewak S.A. rapidly internationalized their technology startup. Dewak was founded by five unemployed Colombians in June 2008. Two years later, foreign sales comprised 95% of the firm’s revenue and provided the founders with full-time employment. Dewak’s only channel to market was via online social media networks. Recognizing that entrepreneurs can use social media to amplify their tacit knowledge and convert it into sellable products and services contributes to the development of a learning-based view of rapid internationalization from inception. The article provides entrepreneurs seeking to launch and grow global businesses with four recommendations that may save them time and money and increase the size of their addressable markets.

  11. Gazelles, unicorns, and dragons battle cancer through the Nanotechnology Startup Challenge.

    Science.gov (United States)

    Truman, Rosemarie; Locke, Cody J

    On March 4th, 2016, Springer's C ancer Nanotechnology office promoted the launch of the Nanotechnology Startup Challenge in Cancer ( NSC 2 ). This innovation-development model is a partnership among our company, the Center for Advancing Innovation (CAI), MedImmune, the global biologics arm of AstraZeneca, and multiple institutes at the National Institutes of Health (NIH). NSC 2 "crowdsources" talent from around the world to launch startups with near-term, commercially viable cancer nanotechnology inventions, which were developed by the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI), and the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Crowdsourcing is a process in which one uses the internet to engage a large group of people in an activity, such as NSC 2 . For this initiative, CAI engaged universities, industry professionals, foundations, investors, relevant media outlets, seasoned entrepreneurs, and life sciences membership organizations to request that they participate in the challenge. From this outreach, fifty-six key thought leaders have enrolled in NSC 2 as judges, mentors, and/or advisors to challenge teams (http://www.nscsquared.org/judges.html). Along with crowdsourcing talent to bolt startups around NIH inventions, NSC 2 will also catalyze the launch of companies around "third-party" cancer nanotechnology inventions, which were conceived and developed outside of the NIH. Twenty-eight robust teams were accepted to the challenge on March 14th, 2016.

  12. [Factors of the rapid startup for nitrosation in sequencing batch reactor].

    Science.gov (United States)

    Li, Dong; Tao, Xiao-Xiao; Li, Zhan; Wang, Jun-An; Zhang, Jie

    2011-08-01

    The approach and factors for realizing the rapid startup of nitrosation were researched at the low level of dissolved oxygen (DO) in sequencing batch reactor (SBR). The main parameters of the reactor were controlled as follows: DO were 0.15-0.40 mg/L, pH values kept from 7.52 to 8.30, temperature maintained at 22.3-27.1 degrees C, and time of aeration was 8 hours. The purpose of rapid startup for nitrosation was achieved after 57 cycles (36 d) with the alternative influent of high and low ammonium wastewater (the mean values were 245.28 mg/L and 58.08 mg/L respectively) in a SBR, and the nitrosation rate was even 100%. Factors of accumulation of nitrite were investigated and the effects of DO and pH were analyzed during the startup for nitrosation. The results showed that it could improve the efficiency of nitrosation when DO concentration was increased appropriately. The activity of nitrite oxidizing bacteria (NOB) was recovered gradually when DO was higher than 0.72 mg/L. The key factor of controlling nitrosation reaction was the concentration of free ammonia (FA), while the final factor was the concentration of DO. pH was a desired controlling parameter to show the end of nitrification in a SBR cycle, while DO concentration did not indicate the finishing of SBR nitrification accurately because it increased rapidly before ammonia nitrogen was oxidized absolutely.

  13. Numerical analysis of start-up operation of a tubular solid oxide fuel cell

    Energy Technology Data Exchange (ETDEWEB)

    Barzi, Y. Mollayi; Ghassemi, M.; Hamedi, M.H. [Department of Mechanical Engineering, K.N. Toosi University of Technology, Tehran (Iran)

    2009-02-15

    The purpose of the current study is to numerically predict the start up behavior of a tubular solid oxide fuel cell (SOFC) using a 2-D transient model. The developed model provides the transient response of the start-up mode as well as the steady state operation of the SOFC. A code based on finite volume method is utilized to solve the transient nonlinear transport equations of the cell (momentum, species and energy equations). To account for the Ohmic losses and Joule heating of the current that passes through the cell body, a discretized network circuit is adopted. The local electrochemical parameters are calculated based on the local pressure, temperature, and concentrations of the species. At each time step an iterative procedure is used to solve the electrochemical, electrical and transport equations simultaneously. The model predicts the cell output voltage, the local EMF and the state variables (pressure, temperature and species concentration) during the start up. It also predicts the cell heat-up rate for hot input gases as well as the start up time of the SOFC. The results show that the gases mass flow rate and temperature affect the heat-up rate. Also during the start-up, the cell electrical response is about 2.5 times quicker than the cell temperature response. The start-up time for the cell output voltage is about 50 min. (author)

  14. Impact of reactor configuration on anammox process start-up: MBR versus SBR.

    Science.gov (United States)

    Tao, Yu; Gao, Da-Wen; Fu, Yuan; Wu, Wei-Min; Ren, Nan-Qi

    2012-01-01

    Anaerobic ammonium oxidation (anammox) is an energy saving biological nitrogen removal process which was limited to slow growth rate of anammox bacteria during start-up period. This study investigated the start-up of anammox process by a laboratory sequential batch reactor (SBR) for 218 days and subsequently modified the reactor as a membrane bioreactor (MBR) for 178 days. Modification of a SBR as MBR with installation of an external membrane module resulted in acceleration of specific anammox activity by 19 times. The acceleration of specific anammox activity with MBR was further confirmed by starting-up another MBR for a 242 day period. Molecular microbial analyses showed that Candidatus "Brocadia anammoxidans" and Candidatus "Kuenenia stuttgartiensis" were the dominant species in the inocula and biomass developed in the reactor. The start-up with MBR appeared to be more effective than SBR for the enrichment of anammox bacteria due to high sludge retention property of MBR configuration. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Theoretical analysis of start-up power in helium pulsating heat pipe

    Science.gov (United States)

    Li, Monan; Huang, Rongjin; Xu, Dong; Li, Laifeng

    2017-02-01

    An analytical model for one-turn helium pulsating heat pipes (PHPs) with single liquid slug and vapor plug is established in present study. When an additional heat power takes place in the evaporating section, temperature and pressure will increase. The pressure wave travels through vapor and liquid phases at different speed, producing a pressure difference in the system, which acts as an exciting force to start up the oscillating motion. Results show that the start-up power of helium PHP is related to the filling ratio. The start-up power increases with the filling ration. However, there exist an upper limit. Furthermore, the start-up power also depends on the inclination angle of PHP. When the inclination angle increases, the heat input needed to start up the oscillating motion decreases. But for one-turn helium PHP, it can not be started up when the inclination angle is up to 90°, equalling to horizontal position,. While the inclination angle ranges between 0° (vertical position) and 75°, it can operate successfully.

  16. Flow rate, syringe size and architecture are critical to start-up performance of syringe pumps.

    Science.gov (United States)

    Neff, S B; Neff, T A; Gerber, S; Weiss, M M

    2007-07-01

    Significant start-up delays are inherent to syringe infusion pumps, particularly at low infusion rates, as routinely used in children's anaesthesia and intensive care. Such delays are mainly the result of engagement of gears in the mechanical drive or compliance of the syringe assembly. The purpose of the present study was to determine the effect of flow rate, syringe size and syringe architecture on fluid delivery during infusion start-up. Elapsed time from infusion start to achievement of steady-state flow was gravimetrically determined for various infusion rates (0.1, 0.5, 1 mL h-1), different syringe sizes (10-, 20-, 30-, 50-mL) and syringes of two different brands (BD and Codan). Four measurements for each condition were performed with two identical Alaris Asena GH syringe infusion pumps (total of eight experiments). Statistical analysis was done by two-way ANOVA with Bonferroni's post-test; P brand in comparison with the Codan syringes (P < 0.01). Highest possible flow rate, smaller sized syringes and syringe plungers with reduced compressibility should be preferred in order to avoid significant start-up delays in fluid delivery.

  17. Rapid start-up of one-stage deammonification MBBR without addition of external inoculum.

    Science.gov (United States)

    Kanders, Linda; Ling, Daniel; Nehrenheim, Emma

    2016-12-01

    In recent years, the anammox process has emerged as a useful method for robust and efficient nitrogen removal in wastewater treatment plants (WWTPs). This paper evaluates a one-stage deammonification (nitritation and anammox) start-up using carrier material without using anammox inoculum. A continuous laboratory-scale process was followed by full-scale operation with reject water from the digesters at Bekkelaget WWTP in Oslo, Norway. A third laboratory reactor was run in operational mode to verify the suitability of reject water from thermophilic digestion for the deammonification process. The two start-ups presented were run with indigenous bacterial populations, intermittent aeration and dilution, to favour growth of the anammox bacterial branches. Evaluation was done by chemical and fluorescence in situ hybridization analyses. The results demonstrate that anammox culture can be set up in a one-stage process only using indigenous anammox bacteria and that a full-scale start-up process can be completed in less than 120 days.

  18. Time-Frequency Analysis of Rocket Nozzle Wall Pressures During Start-up Transients

    Science.gov (United States)

    Baars, Woutijn J.; Tinney, Charles E.; Ruf, Joseph H.

    2011-01-01

    Surveys of the fluctuating wall pressure were conducted on a sub-scale, thrust- optimized parabolic nozzle in order to develop a physical intuition for its Fourier-azimuthal mode behavior during fixed and transient start-up conditions. These unsteady signatures are driven by shock wave turbulent boundary layer interactions which depend on the nozzle pressure ratio and nozzle geometry. The focus however, is on the degree of similarity between the spectral footprints of these modes obtained from transient start-ups as opposed to a sequence of fixed nozzle pressure ratio conditions. For the latter, statistically converged spectra are computed using conventional Fourier analyses techniques, whereas the former are investigated by way of time-frequency analysis. The findings suggest that at low nozzle pressure ratios -- where the flow resides in a Free Shock Separation state -- strong spectral similarities occur between fixed and transient conditions. Conversely, at higher nozzle pressure ratios -- where the flow resides in Restricted Shock Separation -- stark differences are observed between the fixed and transient conditions and depends greatly on the ramping rate of the transient period. And so, it appears that an understanding of the dynamics during transient start-up conditions cannot be furnished by a way of fixed flow analysis.

  19. Start-up designs for response-adaptive randomization procedures with sequential estimation.

    Science.gov (United States)

    Haines, Linda M; Sadiq, Hassan

    2015-09-20

    Response-adaptive randomization procedures are appropriate for clinical trials in which two or more treatments are to be compared, patients arrive sequentially and the response of each patient is recorded before the next patient arrives. However, for those procedures that involve sequential estimation of model parameters, start-up designs are commonly required in order to provide initial estimates of the parameters. In this paper, a suite of such start-up designs for two treatments and binary patient responses are considered and compared in terms of the numbers of patients required in order to give meaningful parameters estimates, the number of patients allocated to the better treatment, and the bias in the parameter estimates. It is shown that permuted block designs with blocks of size 4 are to be preferred over a wide range of parameter values. For the case of two treatments, normal responses and selected start-up procedures, a design incorporating complete randomization followed appropriately by repeats of one of the treatments yields the minimum expected number of patients and is to be preferred. Copyright © 2015 John Wiley & Sons, Ltd.

  20. Electrospun nanofibers as versatile interfaces for efficient gene delivery

    OpenAIRE

    Lee, Slgirim; Jin, Gyuhyung; Jang, Jae-Hyung

    2014-01-01

    The integration of gene delivery technologies with electrospun nanofibers is a versatile strategy to increase the potential of gene therapy as a key platform technology that can be readily utilized for numerous biomedical applications, including cancer therapy, stem cell therapy, and tissue engineering. As a spatial template for gene delivery, electrospun nanofibers possess highly advantageous characteristics, such as their ease of production, their ECM-analogue nature, the broad range of cho...

  1. Connecting leadership and learning: Do versatile learners make connective leaders?

    OpenAIRE

    Robinson, Jill L.

    2016-01-01

    Recent failures in leadership, suggest that creating better-quality leadership development programs is critical. In moving from theory to practice, this paper examined the relationship between learning style and leadership style which may enable us to move away from one-size-fits-all leadership development programs. Utilizing Kolb’s Experiential Learning Model and Connective Leadership theory, approximately 3600 college students were analyzed to discover whether versatility in learning styles...

  2. Connecting Leadership and Learning: Do Versatile Learners make Connective Leaders?

    OpenAIRE

    Jill L. Robinson

    2016-01-01

    Abstract Recent failures in leadership, suggest that creating better-quality leadership development programs is critical. In moving from theory to practice, this paper examined the relationship between learning style and leadership style which may enable us to move away from one-size-fits-all leadership development programs. Utilizing Kolb’s Experiential Learning Model and Connective Leadership theory, approximately 3600 college students were analyzed to discover whether versatility in le...

  3. Versatile composite resins simplifying the practice of restorative dentistry.

    Science.gov (United States)

    Margeas, Robert

    2014-01-01

    After decades of technical development and refinement, composite resins continue to simplify the practice of restorative dentistry, offering clinicians versatility, predictability, and enhanced physical properties. With a wide range of products available today, composite resins are a reliable, conservative, multi-functional restorative material option. As manufacturers strive to improve such properties as compression strength, flexural strength, elastic modulus, coefficient of thermal expansion, water sorption, and wear resistance, several classification systems of composite resins have been developed.

  4. A Combinatorial Auction among Versatile Experts and Amateurs

    Science.gov (United States)

    Ito, Takayuki; Yokoo, Makoto; Matsubara, Shigeo

    Auctions have become an integral part of electronic commerce and a promising field for applying multi-agent technologies. Correctly judging the quality of auctioned goods is often difficult for amateurs, in particular, in Internet auctions. However, experts can correctly judge the quality of goods. In this situation, it is difficult to make experts tell the truth and attain an efficient allocation, since experts have a clear advantage over amateurs and they would not reveal their valuable information without some reward. In our previous work, we have succeeded in developing such auction protocols under the following two cases: (1) the case of a single-unit auction among experts and amateurs, and (2) the case of a combinatorial auction among single-skilled experts and amateurs. In this paper, we focus on versatile experts. Versatile experts have an interest in, and expert knowledge on the qualities of several goods. In the case of versatile experts, there would be several problems, e.g., free riding problems, if we simply extended the previous VCG-style auction protocol. Thus, in this paper, we employ PORF (price-oriented, rationing-free) protocol for designing our new protocol to realize a strategy-proof auction protocol for experts. In the protocol, the dominant strategy for experts is truth-telling. Also, for amateurs, truth-telling is the best response when two or more experts select the dominant strategy. Furthermore, the protocol is false-name-proof.

  5. Connecting Leadership and Learning: Do Versatile Learners make Connective Leaders?

    Directory of Open Access Journals (Sweden)

    Jill L. Robinson

    2016-03-01

    Full Text Available Abstract Recent failures in leadership, suggest that creating better-quality leadership development programs is critical. In moving from theory to practice, this paper examined the relationship between learning style and leadership style which may enable us to move away from one-size-fits-all leadership development programs. Utilizing Kolb’s Experiential Learning Model and Connective Leadership theory, approximately 3600 college students were analyzed to discover whether versatility in learning styles translates into versatility in leadership styles. One group of versatile learners reported using a wider range of leadership styles suggesting that learning flexibility may transfer to leadership flexibility. Surprisingly, learners of all types reported utilizing Power and Intrinsic styles of leadership above all others. Implications for leadership development include considering individual differences when crafting leadership programs, matching learning styles to leader training, and the need to move beyond one set of leadership behaviors to increase flexibility in dealing with complex situations. Using a large sample rarely seen in management studies, this paper makes key contributions to the literature. 

  6. Neuro-estimator based GMC control of a batch reactive distillation.

    Science.gov (United States)

    Prakash, K J Jithin; Patle, Dipesh S; Jana, Amiya K

    2011-07-01

    In this paper, an artificial neural network (ANN)-based nonlinear control algorithm is proposed for a simulated batch reactive distillation (RD) column. In the homogeneously catalyzed reactive process, an esterification reaction takes place for the production of ethyl acetate. The fundamental model has been derived incorporating the reaction term in the model structure of the nonreactive distillation process. The process operation is simulated at the startup phase under total reflux conditions. The open-loop process dynamics is also addressed running the batch process at the production phase under partial reflux conditions. In this study, a neuro-estimator based generic model controller (GMC), which consists of an ANN-based state predictor and the GMC law, has been synthesized. Finally, this proposed control law has been tested on the representative batch reactive distillation comparing with a gain-scheduled proportional integral (GSPI) controller and with its ideal performance (ideal GMC). Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

  7. Reactive Programming in Java

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Reactive Programming in gaining a lot of excitement. Many libraries, tools, and frameworks are beginning to make use of reactive libraries. Besides, applications dealing with big data or high frequency data can benefit from this programming paradigm. Come to this presentation to learn about what reactive programming is, what kind of problems it solves, how it solves them. We will take an example oriented approach to learning the programming model and the abstraction.

  8. Impeller radial force evolution in a large double-suction centrifugal pump during startup at the shut-off condition

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Zhichao [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Wang, Fujun, E-mail: wangfj@cau.edu.cn [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System, China Agricultural University, Beijing 100083 (China); Yao, Zhifeng [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System, China Agricultural University, Beijing 100083 (China); Tao, Ran [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Xiao, Ruofu [College of Water Resources and Civil Engineering, China Agricultural University, Beijing 100083 (China); Beijing Engineering Research Center of Safety and Energy Saving Technology for Water Supply Network System, China Agricultural University, Beijing 100083 (China); Li, Huaicheng [Shanghai Liancheng (Group) Co., Ltd., Shanghai 201812 (China)

    2016-12-15

    Highlights: • Conclude the characteristics of transient radial force in the startup process for a large double-suction centrifugal pump. • The overall direction of the radial force during startup process is also confirmed. • A formula used to calculate the transient radial force during startup process is proposed. • A relationship between radial force variation and axial vortex development in blade channel during the startup process is established. The mechanism of the radial force evolution is revealed. - Abstract: Double-suction centrifugal pumps play an important role in the main feedwater systems of nuclear power plant. The impeller radial force in a centrifugal pump varies dramatically during startup at the shut-off condition. In this study, the startup process of a large double-suction centrifugal pump is investigated using CFD. During testing, the impeller speed is accelerated from zero to its rated speed in 1.0 s (marked as t{sub 0}) and is then maintained at the rated speed. The results show that the radial force increase lags behind the impeller speed increase. At 0–0.4t{sub 0}, the radial force is small (approaching zero). At 0.4–1.4t{sub 0}, the radial force increases rapidly. After 1.4t{sub 0}, the average radial force stabilizes and reaches its maximum value of 55,619 N. The observed maximum radial force value during startup is approximately nine times as high as the radial force under rated condition. During startup, the overall radial force direction is proximate to the radial line located 25° from the volute tongue along circumferential direction. A transient radial force formula is proposed to evaluate the changes in radial force during startup. The streamline distribution in impeller passages and the impeller outlet pressure profile varying over time are produced. The relationship between radial force evolution and the varying axial-to-spiral vortex structure is analyzed. The radial force change mechanism is revealed. This research

  9. Flows of Reactive Fluids

    CERN Document Server

    Prud'homme, Roger

    2010-01-01

    The modeling of reactive flows has progressed mainly with advances in aerospace, which gave birth to a new science called aerothermochemistry, as well as through developments in chemical and process engineering. The methods employed, the phenomena investigated, and the aims of modeling differ for each field; however, in all cases, the results obtained have considerably enriched the working knowledge of reactive flows. This work examines basic concepts and methods necessary to study reactive flows and transfer phenomena in areas such as fluid mechanics, thermodynamics, and chemistry. Specific topics covered include: * Equations of state * Transfer phenomena and chemical kinetics * Balance equations of reactive flows * Dimensionless numbers and similarity * Chemical reactors * Coupled phenomena * Turbulent flow concepts * Boundary layers and fluid layers * Reactive and nonreactive waves * Interface phenomena * Multiphase flow concepts The book presents tools of interest to graduate students, researchers in math...

  10. How to start a company? Analysis of three start-up companies in Finland : ClipMe, JerryBag and Tutor Tigers

    OpenAIRE

    Lam, Phuc

    2014-01-01

    Start-up is becoming a trend in the current economy condition while huge and global companies are still not a safe place. However, there are not so many start-ups that have succeeded in their paths. Majority of failures come from financing aspects of start-up in the early stage. This paper studies the effective financing methods for start-ups in general. The thesis aims to construct and consolidate theories around financing topic in order to offer recommendations after the finding. The th...

  11. Versatility of Alkyne-Modified Poly(Glycidyl Methacrylate) Layers for Click Reactions

    Energy Technology Data Exchange (ETDEWEB)

    Soto-Cantu, Dr. Erick [University of Tennessee, Knoxville (UTK); Lokitz, Bradley S [ORNL; Hinestrosa Salazar, Juan Pablo [Clemson University; Deodhar, Chaitra [University of Tennessee, Knoxville (UTK); Messman, Jamie M [ORNL; Ankner, John Francis [ORNL; Kilbey, II, S Michael [ORNL

    2011-01-01

    Functional soft interfaces are of interest for a variety of technologies. We describe three methods for preparing substrates with alkyne groups, which show versatility for 'click' chemistry reactions. Two of the methods have the same root: formation of thin, covalently attached, reactive interfacial layers of poly(glycidyl methacrylate) (PGMA) via spin coating onto silicon wafers followed by reactive modification with either propargylamine or 5-hexynoic acid. The amine or the carboxylic acid moieties react with the epoxy groups of PGMA, creating interfacial polymer layers decorated with alkyne groups. The third method consists of using copolymers comprising glycidyl methacrylate and propargyl methacrylate (pGP). The pGP copolymers are spin coated and covalently attached on silicon wafers. For each method, we investigate the factors that control film thickness and content of alkyne groups using ellipsometry, and study the nanophase structure of the films using neutron reflectometry. Azide-terminated polymers of methacrylic acid and 2-vinyl-4,4-dimethylazlactone synthesized via reversible addition-fragmentation chain transfer polymerization were attached to the alkyne-modified substrates using 'click' chemistry, and grafting densities in the range of 0.007-0.95 chains nm{sup -2} were attained. The maximum density of alkyne groups attained by functionalization of PGMA with propargylamine or 5-hexynoic acid was approximately 2 alkynes nm{sup -3}. The alkyne content obtained by the three decorating approaches was sufficiently high that it was not the limiting factor for the click reaction of azide-capped polymers.

  12. Design of a Compact and Versatile Bench Scale Tubular Reactor

    Directory of Open Access Journals (Sweden)

    R. Prasad

    2009-06-01

    Full Text Available A compact and versatile laboratory tubular reactor has been designed and fabricated keeping in view of reducing capital cost and minimising energy consumption for gas/vapor-phase heterogeneous catalytic reactions. The reactor is consisted of two coaxial corning glass tubes with a helical coil of glass tube in between the coaxial tubes serving as vaporiser and pre-heater, the catalyst bed is in the inner tube. A schematic diagram of the reactor with detailed dimensions and working principles are described. The attractive feature of the reactor is that the vaporiser, pre-heater and fixed bed reactor are merged in a single compact unit. Thus, the unit minimises separate vaporiser and pre-heater, also avoids separate furnaces used for them and eliminate auxiliary instrumentation such as temperature controller etc. To demonstrate the system operation and illustrate the key features, catalyst screening data and the efficient collection of complete, and accurate intrinsic kinetic data are provided for oxidation of CO over copper chromite catalyst. CO oxidation is an important reaction for auto-exhaust pollution control. The suitability of the versatile nature of the reactor has been ascertained for catalytic reactions where either volatile or vaporizable feeds can be introduced to the reaction zone, e.g. oxidation of iso-octane, reduction of nitric oxide, dehydrogenation of methanol, ethanol and iso-propanol, hydrogenation of nitrobenzene to aniline, etc. Copyright (c 2009 by BCREC. All Rights reserved.[Received: 10 February 2009, Accepted: 9 May 2009][How to Cite: R. Prasad, G. Rattan. (2009. Design of a Compact and Versatile Bench Scale Tubular Reactor. Bulletin of Chemical Reaction Engineering and Catalysis, 4(1: 5-9.  doi:10.9767/bcrec.4.1.1250.5-9][How to Link/ DOI: http://dx.doi.org/10.9767/bcrec.4.1.1250.5-9

  13. Versatile transmission ellipsometry to study linear ferrofluid magneto-optics.

    Science.gov (United States)

    Kooij, E S; Gâlcă, A C; Poelsema, B

    2006-12-01

    Linear birefringence and dichroism of magnetite ferrofluids are studied simultaneously using spectroscopic ellipsometry in transmission mode. It is shown that this versatile technique enables highly accurate characterisation of magneto-optical phenomena. Magnetic field-dependent linear birefringence and dichroism as well as the spectral dependence are shown to be in line with previous results. Despite the qualitative agreement with established models for magneto-optical phenomena, these fail to provide an accurate, quantitative description of our experimental results using the bulk dielectric function of magnetite. We discuss the results in relation to these models, and indicate how the modified dielectric function of the magnetite nanoparticles can be obtained.

  14. Versatile supramolecular organogel with outstanding stability toward aqueous interfaces.

    Science.gov (United States)

    Bonifazi, Evelyn L; Edelsztein, Valeria C; Menéndez, Guillermo O; Samaniego López, Cecilia; Spagnuolo, Carla C; Di Chenna, Pablo H

    2014-06-25

    In this communication, we report on a novel and versatile low-molecular-weight organogelator. The methanolic gel exhibits an exceptional water-enhanced stability as evidenced by a 30 °C increase in Tg with up to 10%v/v of water. This atypical property not observed with other solvents makes of this supramolecular gel a highly stable matrix compatible with aqueous interfaces. As a proof of principle we present the sensing performance of a symmetric tricarbocyanine fluorophore bearing a Zn(II)chelator unit. The system retained its remarkable physical integrity for a long period of time opening new possibilities for other organic-aqueous interface applications.

  15. A Versatile Glass Processor for High-Performance Photonic Platforms

    Science.gov (United States)

    2015-12-08

    SECURITY CLASSIFICATION OF: With the DURIP fund, we acquire a glass processing station to enhance our capabilities to achieve ultra-high performance...funded by PECASE (supported by DoD-ARO under the contract/grant number W911NF-12-1-0026) on high performance optical sensors. The multipurpose glass ...Distribution Unlimited UU UU UU UU 08-12-2016 1-Aug-2014 31-Jul-2015 Final Report: A Versatile Glass Processor for High-Performance Photonic Platforms The views

  16. CORRTEX: a compact and versatile system for time domain reflectometry

    Energy Technology Data Exchange (ETDEWEB)

    Deupree, R.G.; Eilers, D.D.; McKown, T.O.; Storey, W.H.

    1981-01-01

    The CORRTEX (COntinuous Reflectometry for Radius versus Time EXperiments) system was designed to be an adaptable and versatile unit for performing time domain reflectometry (TDR). The system consists of a coaxial cable, a digital TDR, which uses a Motorola 6800 microprocessor, a power source or battery pack, and an output terminal or recording driver. Desirable criteria for the system are discussed as well as the operation of the CORRTEX system. The types of present applications of the CORRTEX system are summarized and data presented.

  17. Read-only holographic versatile disc system using laser diode

    Science.gov (United States)

    Horimai, Hideyoshi; Tan, Xiaodi

    2006-05-01

    A Read-only Holographic Versatile Disc (HVD-ROM) system, using a laser diode for high capacity and high data transfer rates storage system, is proposed. With the collinear technologies' unique configuration the optical pickup can be designed as small as a DVD's, and can be placed on one side of the disc. With the HVD's special structure, the system can servo the focus/tracking and locate reading/writing address. The experiments and theoretical studies suggest that a laser diode is very suitable as a light source of our HVD-ROM system.

  18. The Q-System: A Versatile Expression System for Drosophila.

    Science.gov (United States)

    Riabinina, Olena; Potter, Christopher J

    2016-01-01

    Binary expression systems are flexible and versatile genetic tools in Drosophila. The Q-system is a recently developed repressible binary expression system that offers new possibilities for transgene expression and genetic manipulations. In this review chapter, we focus on current state-of-the-art Q-system tools and reagents. We also discuss in vivo applications of the Q-system, together with GAL4/UAS and LexA/LexAop systems, for simultaneous expression of multiple effectors, intersectional labeling, and clonal analysis.

  19. Versatile test rig for the evaluation of thermionic electron guns

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, H.; Cleaver, J.R.A. (Cambridge Univ. (UK). Dept. of Engineering); Catto, C.J.D. (Cambridge Sanning Ltd. (UK)); Kanitkar, P.L. (Poona Univ. (India). Dept. of Physics); Smith, D.J. (Cambridge Univ. (UK). High Resolution Electron Microscope)

    1982-12-01

    Measurements of the brightness and the electron energy distribution for high-performance electron guns for electron-optical instruments must take account of the small effective size of the electron source and the directional dependence of the emission from it. A versatile electron gun test rig has been developed to enable measurements to be made under realistic operating conditions. Energy distribution can be determined with a hemispherical cup retarding-field analyser, and brightness can be measured at up to 100 kV by both two-aperture and crossover-projection methods. Some measured characteristics of lanthanum hexaboride cathodes are given, with measurements of conventional tungsten cathodes for comparison.

  20. Versatile Organic Chemistry on Vanadium-Based Multi-Electron Reservoirs.

    Science.gov (United States)

    Nachtigall, Olaf; Spandl, Johann

    2018-01-04

    We report the synthesis, post-functionalization, and redox behavior of two organically functionalized aggregates, [V 6 O 7 (OMe) 9 {(OCH 2 ) 3 C-CH 2 N 3 }] and [V 6 O 7 (OMe) 9 {(OCH 2 ) 3 C-NH 2 }]. All twelve μ 2 -oxo groups on the edges of the Lindqvist-type {V 6 O 19 } core were replaced by alkoxo ligands. The absence of a negative charge and the closed organic shell make these neutral mixed-valence compounds very stable towards hydrolysis and well soluble in almost all common organic solvents. These are important advantages over classical POMs. By post-functionalization through copper(I)-catalyzed Huisgen cycloaddition or imine formation, various organic moieties could be introduced. Even a well-soluble trimer composed of three hexanuclear vanadium units connected through an aromatic triimino core was synthesized and studied. The diverse redox behavior, the versatile reactivity, the good stability, and the excellent solubility make our vanadium compounds highly interesting for applications as building blocks in macromolecular chemistry as well as redox labels in biochemistry. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. The effect of house prices on business start-ups: A review and analysis using Swedish regional data

    Directory of Open Access Journals (Sweden)

    Björn Berggren

    2017-01-01

    Full Text Available Entrepreneurs are at the core of economic development in that they start new businesses or make existing firms grow. To fulfill this important role, entrepreneurs need access to finance. Owing to information asymmetry and the relatively high risk associated with business start-ups, many financiers shy away from engaging in relationships with firms during the early stages of their development. Based on the existing body of knowledge on the financing of entrepreneurship, we know that insider finance is of paramount importance in the early stages of firms’ development. We expand this knowledge base by analyzing the influence of house prices on business start-ups across municipalities in Sweden. In our analysis, we include data from all municipalities in Sweden. Our data on house prices and control variables are collected in period one, and our data on the frequency of start-ups are collected in period two. We find that rising house prices in a municipality lead to a higher frequency of start-ups. In our regression analysis, we find that a 1% increase in house prices leads to a 0.14% increase in start-ups. Our findings are in line with the limited international research that has been previously conducted, and for this reason, they could be seen as a vital addition to the existing body of knowledge within the area of entrepreneurship and regional development.

  2. Finding competitive intelligence on Internet start-up companies: a study of secondary resource use and information-seeking processes

    Directory of Open Access Journals (Sweden)

    2001-01-01

    Full Text Available The paper reports findings from a study of CI activities involving Internet start-up companies in the telecommunications industry. The CI gathering was conducted by graduate students in library and information science in the context of a class project for a real business client, itself a small Internet start-up company. The primary objective of the study was to provide empirical insights into the applicability of specific types of secondary information resources to finding competitive intelligence information on small Internet start-up companies. An additional objective was to identify the characteristics of research strategies applied in the collection of CI on Internet start-ups from the perspective of current conceptual frameworks of information-seeking behaviour presented in the library and information science literature. This study revealed some interesting findings regarding the types of secondary information resources that can be used to find competitive intelligence on small, Internet start-up companies. The study also provided insight into the characteristics of the overall information-seeking strategies that are applied in this type of competitive intelligence research.

  3. 3RIP trip startup test simulation of TRACE/PARCS model for Lungmen ABWR under different power and flow conditions

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shu-Ming; Wang, Jong-Rong; Chen, Hsiung-Chih; Shih, Chunkuan; Chen, Shao-Wen [National Tsing Hua Univ., Hsin Chu, Taiwan (China). Inst. of Nuclear Engineering and Science; Lin, Hao-Tzu [Atomic Energy Council, Taoyuan City, Taiwan (China). Inst. of Nuclear Energy Research

    2015-12-15

    Lungmen nuclear power plant project started long time ago, it is not yet commercially operated but Taiwan Power Company has already prepared for its startup tests. 3RIP trip startup test is one of them. Three of the 10 RIPs will be manually tripped in the test. Response of the plant for this transient will be watched and recorded to check if the test criteria are satisfied. This paper is a result of code simulation of 3RIP trip startup test of Lungmen ABWR nuclear power plant. Thermal hydraulic code TRACE coupled with neutronics code PARCS were used to build the simulation model of Lungmen nuclear power plant. Startup tests under different plant power and flow conditions are considered in this research. A sensitivity study on the impact of different pump moment of inertia has been performed. Simulation results with TRACE and PARCS shows that the acceptance criteria for this startup test can be satisfied and the impact of different pump inertia is little.

  4. Having your cake and eating it too; effective engagement in start-ups from an academic seat

    Science.gov (United States)

    Mirkin, Chad

    2012-02-01

    In order for scientific advances to have a positive impact on society, they must be successfully transitioned from conceptually fundamental endeavors in academic research laboratories to valuable enabling technologies at start-up companies. Nanosphere, NanoInk, and AuraSense are three start-up companies that have been spun out of Northwestern based on research initiated in my laboratory. These companies are focused on commercializing nanotechnology-based applications in the life science and semiconductor industries and have turned discoveries from my lab into viable commercial products. For example, several of the systems developed at these start-ups are in the clinical trial phase, with one already approved by the FDA, and they are poised to have a positive world-wide impact. Herein, I discuss the challenges associated with identifying commercial value in academic research projects, securing intellectual property, forming a company as a legal entity, and locating sources of start-up funds. Further, I will discuss the rewards of venturing into such enterprises and the ways of ensuring a start-up company's long-term success, while juggling the numerous responsibilities of an academic seat. I argue that these two activities are done not in competition, but rather are integral for driving the type of high-level, synergistic scientific research that is being done today.

  5. Surface-to-surface biofilm transfer: a quick and reliable startup strategy for mixed culture microbial fuel cells.

    Science.gov (United States)

    Vogl, Andreas; Bischof, Franz; Wichern, Marc

    2016-01-01

    The startup of microbial fuel cells (MFCs) is known to be prone to failure or result in erratic performance impeding the research. The aim of this study was to advise a quick launch strategy for laboratory-scale MFCs that ensures steady operation performance in a short period of time. Different startup strategies were investigated and compared with membraneless single chamber MFCs. A direct surface-to-surface biofilm transfer (BFT) in an operating MFC proved to be the most efficient method. It provided steady power densities of 163 ± 13 mWm(-2) 4 days after inoculation compared to 58 ± 15 mWm(-2) after 30 days following a conventional inoculation approach. The in situ BFT eliminates the need for microbial acclimation during startup and reduces performance fluctuations caused by shifts in microbial biodiversity. Anaerobic pretreatment of the substrate and addition of suspended enzymes from an operating MFC into the new MFC proved to have a beneficial effect on startup and subsequent operation. Polarization methods were applied to characterize the startup phase and the steady state operation in terms of power densities, internal resistance and power overshoot during biofilm maturation. Applying this method a well-working MFC can be multiplied into an array of identically performing MFCs.

  6. Development and optimization of new generation Start-Up Instrumentation systems (SUI) for domestic CANDU reactors

    Science.gov (United States)

    Nasimi, Elnara

    Due to the age and operating experience of Bruce Power units, equipment ageing and obsolescence has become one of the main challenges that need to be resolved for all systems, structures and components in order to ensure a safe and reliable production of energy. The research objectives of this thesis will focus on methodology for modernization of Start-Up Instrumentation (SUI), both in-core and Control Room equipment, using a new generation of detectors and cables in order to manage obsolescence. The main objective of this thesis is to develop a new systematic approach to SUI installation/replacement procedure development and optimization. Although some additional features, such as real-time data monitoring and storage/archiving solutions for SUI systems are also examined to take full advantage of today's digital technology, the objective of this thesis does not include detailed parametrical studies of detector or system performance. Instead, a number of technological, operational and maintenance issues associated with Start-Up Instrumentation systems at Bruce Power will be identified in this project and a structured approach to developing a replacement/installation procedure that can be standardized and used across all of the domestic CANDU stations is proposed. Finally, benefits of Hierarchical Control Chart (HCC) methodology for all stages of plant life management, such as system design, development, operation and maintenance are demonstrated. Keywords: Task Breakdown and Analysis methodology, installation/removal procedure development and optimization, risk-based analysis and optimization, Hierarchical Control Chart (HCC) methodology for system maintenance and troubleshooting, Start-Up Instrumentation (SUI), Ion Chambers, Fission Chambers, proportional counters, Shutdown System 1 (SDS1), Shutdown System 2 (SDS2).

  7. Enhanced start-up of anaerobic facultatively autotrophic biocathodes in bioelectrochemical systems

    KAUST Repository

    Zaybak, Zehra

    2013-12-01

    Biocathodes in bioelectrochemical systems (BESs) can be used to convert CO2 into diverse organic compounds through a process called microbial electrosynthesis. Unfortunately, start-up of anaerobic biocathodes in BESs is a difficult and time consuming process. Here, a pre-enrichment method was developed to improve start-up of anaerobic facultatively autotrophic biocathodes capable of using cathodes as the electron donor (electrotrophs) and CO2 as the electron acceptor. Anaerobic enrichment of bacteria from freshwater bog sediment samples was first performed in batch cultures fed with glucose and then used to inoculate BES cathode chambers set at -0.4V (versus a standard hydrogen electrode; SHE). After two weeks of heterotrophic operation of BESs, CO2 was provided as the sole electron acceptor and carbon source. Consumption of electrons from cathodes increased gradually and was sustained for about two months in concert with a significant decrease in cathode chamber headspace CO2. The maximum current density consumed was -34±4mA/m2. Biosynthesis resulted in organic compounds that included butanol, ethanol, acetate, propionate, butyrate, and hydrogen gas. Bacterial community analyses based on 16S rRNA gene clone libraries revealed Trichococcus palustris DSM 9172 (99% sequence identity) as the prevailing species in biocathode communities, followed by Oscillibacter sp. and Clostridium sp. Isolates from autotrophic cultivation were most closely related to Clostridium propionicum (99% sequence identity; ZZ16), Clostridium celerecrescens (98-99%; ZZ22, ZZ23), Desulfotomaculum sp. (97%; ZZ21), and Tissierella sp. (98%; ZZ25). This pre-enrichment procedure enables simplified start-up of anaerobic biocathodes for applications such as electrofuel production by facultatively autotrophic electrotrophs. © 2013 Elsevier B.V.

  8. UASB reactor startup for the treatment of municipal wastewater followed by advanced oxidation process

    Directory of Open Access Journals (Sweden)

    Z. A. Bhatti

    2014-09-01

    Full Text Available The present study was done to shorten the start-up time of up-flow anaerobic sludge blanket (UASB reactor. Two different nutrients were used during the UASB start-up period, which was designed to decrease the hydraulic retention time (HRT from 48 to 24 and 12 to 6 hrs at average temperatures of 25-34 ºC. In the first stage, start-up was with glucose for 14 days and then the reactor was also fed with macro- and micronutrients as a synthetic nutrient influent (SNI from 15 to 45 days as the second stage. For the control, a second reactor was kept on glucose feeding from day 1 to 45. The removal efficiencies of the chemical oxygen demand (COD were 80% and 98% on the 6th and 32nd day of the first and second stage, respectively. The maximum substrate removal rate of 0.08 mg COD mg-1 VSS d-1 was observed for glucose and synthetic nutrient influent (SNI on the 8th and 40th days, respectively. When the reactor reached the maximum COD removal efficiency it was then shifted to municipal wastewater (MWW mixed with industrial wastewater. The HRT was reduced gradually with a one week gap while treating MWW. For further cleaning, the UASB effluent was treated with 40% waste hydrogen peroxide. The whole integrated treatment process was successful to reduce the COD by 99%, total suspended solids (TSS by 73%, total nitrogen (TN by 84% and turbidity by 67%.

  9. Fusion core start-up, ignition and burn simulations of reversed-field pinch (RFP) reactors

    Energy Technology Data Exchange (ETDEWEB)

    Chu, Yuh-Yi

    1988-01-01

    A transient reactor simulation model is developed to investigate and simulate the start-up, ignition and burn of a reversed-field pinch reactor. The simulation is based upon a spatially averaged plasma balance model with field profiles obtained from MHD quasi-equilibrium analysis. Alpha particle heating is estimated from Fokker-Planck calculations. The instantaneous plasma current is derived from a self-consistent circuit analysis for plasma/coil/eddy current interactions. The simulation code is applied to the TITAN RFP reactor design which features a compact, high-power-density reversed-field pinch fusion system. A contour analysis is performed using the steady-state global plasma balance. The results are presented with contours of constant plasma current. A saddle point is identified in the contour plot which determines the minimum value of plasma current required to achieve ignition. An optimized start-up to ignition and burn path can be obtained by passing through the saddle point. The simulation code is used to study and optimize the start-up scenario. In the simulations of the TITAN RFP reactor, the OH-driven superconducting EF coils are found to deviate from the required equilibrium values as the induced plasma current increases. This results in the modification of superconducting EF coils and the addition of a set of EF trim coils. The design of the EF coil system is performed with the simulation code subject to the optimization of trim-coil power and current. In addition, the trim-coil design is subject to the constraints of vertical-field stability index and maintenance access. A power crowbar is also needed to prevent the superconducting EF coils from generating excessive vertical field. A set of basic results from the simulation of TITAN RFP reactor yield a picture of RFP plasma operation in a reactor. Investigations of eddy current are also presented. 145 refs., 37 figs., 2 tabs.

  10. Impact of seeding on the start-up of one-stage deammonification MBBRs.

    Science.gov (United States)

    Kanders, Linda; Areskoug, Therese; Schneider, Yvonne; Ling, Daniel; Punzi, Marisa; Beier, Maike

    2014-01-01

    Treating nitrogen-rich reject water from anaerobically digested sludge with deammonification has become a very beneficial side stream process. One common technique is the one-stage moving bed bioreactors (MBBRs), which in comparison with the other deammonification techniques can be started up without seeding anammox bacteria. This study investigated the impact of biofilm seeding on the start-up of one-stage deammonification MBBRs. Two lab-scale reactors were run in parallel with partial nitritation for 56 days until 11% of the carrier area in one reactor was replaced with fully developed deammonification biofilm to work as the seeding material. The seeded reactor started nitrogen reduction immediately up to a plateau of 1.3 g N m⁻² d⁻¹; after another 54 days on day 110, the reduction significantly increased. At the same time, the non-seeded reactor also started to reduce nitrogen due to deammonification. The development was followed with both nitrogen analyses and fluorescence in situ hybridization analyses. On day 134, the biofilm in both reactors contained>90% anammox bacteria and reached maximum nitrogen removal rates of 7.5 and 5.6 g N m⁻² d⁻¹ in the seeded and non-seeded reactor, respectively. Over 80% of the inorganic nitrogen was reduced. In conclusion, the seeding did not contribute to a shorter start-up time or the achieved anammox enrichment, although it did contribute to a partial, immediate nitrogen reduction. The boundary conditions are the most important factors for a successful start-up in a deammonification MBBR system.

  11. Determining the marketing mix for a start-up travel agency aimed at the Belgian market

    OpenAIRE

    Hanák, Marek

    2014-01-01

    This thesis suggests a marketing mix consisting of 4 P's for a start-up travel agency. It created a product according to the quantitative research, n=140, and a qualitative research on the Belgian market. It includes the price of the product according to a competitor analysis, price expectation of the segment and a calculation of all costs connected with providing the service. It suggests also a promotion strategy aimed at the target audience and describes the place in terms point of sale ded...

  12. Study of the Start-Up Ecosystem in Lima, Peru: Analysis of Interorganizational Networks

    Directory of Open Access Journals (Sweden)

    Carlos Hernandez

    2017-04-01

    Full Text Available According to the literature, In the context of changes at a global level the formation of new businesses drives the economy, being important start-ups, which are linked to a community of entrepreneurs, mentors, incubators, accelerators, providers of common services, angel investors, venture capitalists, universities and public support entities, which together configure an ecosystem that is linked to other ecosystems. In this way, this work focuses on the Lima, Peru ecosystem with the aim of providing an understanding of the interorganizational networks that are established based on the analysis of the interactions that occur in the LinkedIn social network. Definitions, methodology, results and conclusions are presented.

  13. Robotic surgery start-up with a fellow as the console surgeon

    DEFF Research Database (Denmark)

    Reinhardt, Susanne; Ifaoui, Inge Boetker; Thorup, Jorgen

    2017-01-01

    OBJECTIVE: Owing to the encouraging data on fellowship training in robotic pyeloplasty and the documented benefits of robotic pyeloplasty, the aim of this study was to test the feasibility of starting up pediatric urological robotic surgery in a center with a limited case volume. MATERIALS AND ME...... learning curve for robotic pyeloplasty will allow pediatric urology fellowship programs to be integrated in the start-up phase of a pediatric robotic program even though the case material is limited. Operative success rates were in accordance with the gold standard of open surgery....

  14. Startup of the Anammox Process in a Membrane Bioreactor (AnMBR) from Conventional Activated Sludge.

    Science.gov (United States)

    Gutwiński, P; Cema, G; Ziembińska-Buczyńska, A; Surmacz-Górska, J; Osadnik, M

    2016-12-01

      In this study, a laboratory-scale anammox process in a membrane bioreactor (AnMBR) was used to startup the anaerobic ammonium oxidation (anammox) process from conventional activated sludge. Stable operation was achieved after 125 days. From that time, nitrogen load was gradually increased. After six months, the average nitrogen removal efficiency exceeded 80%. The highest obtained special anammox activity (SAA) achieved was 0.17 g (-N + -N) (g VSS × d)-1. Fluorescent in situ hybridization also proved the presence of the anammox bacteria, typically a genus of Brocadia anammoxidans and Kuenenia stuttgartiensis.

  15. Modeling startup and shutdown transient of the microlinear piezo drive via ANSYS

    Science.gov (United States)

    Azin, A. V.; Bogdanov, E. P.; Rikkonen, S. V.; Ponomarev, S. V.; Khramtsov, A. M.

    2017-02-01

    The article describes the construction-design of the micro linear piezo drive intended for a peripheral cord tensioner in the reflecting surface shape regulator system for large-sized transformable spacecraft antenna reflectors. The research target -the development method of modeling startup and shutdown transient of the micro linear piezo drive. This method is based on application software package ANSYS. The method embraces a detailed description of the calculation stages to determine the operating characteristics of the designed piezo drive. Based on the numerical solutions, the time characteristics of the designed piezo drive are determined.

  16. Market research and plan for Chinese fast-food restaurant start-up

    OpenAIRE

    Song, Tianhao

    2017-01-01

    CENTRIA UNIVERSITY OF APPLIED SCIENCES Market research and plan for Chinese fast-food restaurant start-up Instructor Due to the popularity of fast-food services in the Helsinki region, this thesis studies the possibility to find out the market opportunities for Chinese traditional fast-food business. Most of the fast-food restaurants opened are according to European flavor, so there is almost a void for Chinese fast-food to fill in, plus the Helsinki region is an area of ...

  17. The Start-up Test of Mechanical Sodium Pump installed in STELLA-1

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Chungho; Kim, Jong-Man; Ko, Yung Joo; Kim, Byeongyeon; Cho, Youngil; Jung, Min-Hwan; Gam, Da-Young; Lee, Yong Bum; Jeong, Ji-Young; Kim, Jong-Bum [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    Testing at the high temperature sodium environments is more expensive and time consuming because of difficulties of operating and maintaining of sodium experimental facilities. Consequent upon those problems, water is often selected as a surrogate test fluid because its important hydraulic properties such as a density and a kinematic viscosity are not only very similar to that of the sodium but also it is cheap, easily available and easy to handle. SFR NSSS System Design Division of Korea Atomic Energy Research Institute (KAERI) is performing a development and demonstration of sodium technology using various sodium experimental facilities, especially STELLA-1. STELLA-1 (Sodium inTegral Effect test Loop for safety simuLation and Assessment) is a large-scale separated effect test facility for demonstrating the thermal-hydraulic performances of major components such as a Sodium-to-Sodium heat exchanger (DHX), Sodium-to-Air heat exchanger (AHX) of the decay heat removal system, and mechanical sodium pump of the primary heat transport system (PHTS). The result of start-up test, most of the instruments and components except for flow control valve are functionally work. Also, we confirmed that performance test of mechanical sodium pump is unable at the high flow rate with lower RPM because pressure drops of pump performance test loop are bigger than the pump head of some cases. To confirm the safety and operability of major components in the sodium-cooled fast reactor (SFR), demonstration of component performance should be carried out before its installation in reactor. So, in order to estimate the hydraulic behavior of the mechanical sodium pump, the performance tests of the model pump with water environment was carried out using a pump vender's experimental facility. Also, to compare the hydraulic characteristic of model pump with water and sodium, the performance test of model pump with sodium environment were performed using STELLA-1. The present paper describes

  18. Social network analysis for startups finding connections on the social web

    CERN Document Server

    Tsvetovat, Maksim

    2011-01-01

    Does your startup rely on social network analysis? This concise guide provides a statistical framework to help you identify social processes hidden among the tons of data now available. Social network analysis (SNA) is a discipline that predates Facebook and Twitter by 30 years. Through expert SNA researchers, you''ll learn concepts and techniques for recognizing patterns in social media, political groups, companies, cultural trends, and interpersonal networks. You''ll also learn how to use Python and other open source tools-such as NetworkX, NumPy, and Matplotlib-to gather, analyze, and vis

  19. Recent Developments In Reactively Sputtered Optical Thin Films

    Science.gov (United States)

    Pawlewicz, W. T.; Martin, P. M.; Hays, D. D.; Mann, I. B.

    1982-04-01

    Highlights of a multiyear effort to develop new or improved thin-film, optical-coating materials through the use of reactive sputtering techniques are presented. Reactive sputtering is shown to be an extremely versatile technique capable of straightforward synthesis of broad classes of materials. The exceptional utility of sputtering for preparation of hard coatings such as oxides, nitrides and novel materials based on Si and Ge is described. Some of these coating materials cannot be made by conventional evaporative techniques. Reactive sputtering allows precise control of coating composition, microstructure and the resulting optical properties. Supporting data are presented for TiO2, for which record high damage thresholds were obtained, and for Si-based coatings, for which record low infrared absorptance was achieved. Transparent conductive indium tin oxide (ITO) coatings with low sheet resistance and high visible and near infrared transmission can also be made. These coatings have many electro-optic contact and electromagnetic shielding applications. Examples of multilayer coatings such as all-dielectric and dielectric-enhanced mirrors made from reactively sputtered materials are included, and simple yet elegant fabrication techniques are introduced. The reactive sputtering technique and equipment used specifically for optical coatings are briefly described, and comparison is made with the conventional evaporative approach.

  20. Versatile aggressive mimicry of cicadas by an Australian predatory katydid.

    Directory of Open Access Journals (Sweden)

    David C Marshall

    Full Text Available BACKGROUND: In aggressive mimicry, a predator or parasite imitates a signal of another species in order to exploit the recipient of the signal. Some of the most remarkable examples of aggressive mimicry involve exploitation of a complex signal-response system by an unrelated predator species. METHODOLOGY/PRINCIPAL FINDINGS: We have found that predatory Chlorobalius leucoviridis katydids (Orthoptera: Tettigoniidae can attract male cicadas (Hemiptera: Cicadidae by imitating the species-specific wing-flick replies of sexually receptive female cicadas. This aggressive mimicry is accomplished both acoustically, with tegminal clicks, and visually, with synchronized body jerks. Remarkably, the katydids respond effectively to a variety of complex, species-specific Cicadettini songs, including songs of many cicada species that the predator has never encountered. CONCLUSIONS/SIGNIFICANCE: We propose that the versatility of aggressive mimicry in C. leucoviridis is accomplished by exploiting general design elements common to the songs of many acoustically signaling insects that use duets in pair-formation. Consideration of the mechanism of versatile mimicry in C. leucoviridis may illuminate processes driving the evolution of insect acoustic signals, which play a central role in reproductive isolation of populations and the formation of species.