A novel BEV concept based on fixed and swappable li-ion battery packs

DEFF Research Database (Denmark)

Barreras, Jorge Varela; Pinto, C.; de Castro, R.

2015-01-01

-based ownership models to distribute the cost of the large battery pack over the vehicle lifetime. A methodology is proposed for the analysis and evaluation of the proposed concept in comparison with a direct owned non swappable single pack BEV, proving that significant improvements on city fuel economy (up to 20......In this paper a novel battery electric vehicle (BEV) concept based on a small fixed and a big swappable li-ion battery pack is proposed in order to achieve: longer range, lower initial purchase price and lower energy consumption at short ranges. For short ranges the BEV is only powered...... by the relatively small fixed battery pack, without the large swappable battery pack. In this way the mass of the vehicle is reduced and therefore the energy consumed per unit distance is improved. For higher ranges the BEV is powered by both battery packs. This concept allows the introduction of subscription...

National trivselsdag med fokus på bevægelse

DEFF Research Database (Denmark)

Holt, Anne-Didde

2016-01-01

breaks”, skriver tre elever. Trivselsdagen gav ligeledes anledning til at dele de gode erfaringer, der indtil nu er udsprunget af ’Trivsel og Bevægelse i Skolen’ - P1 Morgen, P4 Fyn og TV-avisen bragte historier fra dagen på Glamsbjergskolen i Assens, mens P4 Midt og Vest besøgte Haldgård Skole i...... til at fordybe sig i, videreudvikle og vise omverdenen, hvordan der arbejdes med at fremme trivsel gennem bevægelse. Eleverne arbejdede bl.a. med at udvikle og afprøve brain breaks, som er små pauser med bevægelsesaktiviteter, der lægges ind i løbet af den stillesiddende undervisning. Formålet var...... for dem. ”Vi synes brain breaks er vigtige fordi med brain breaks får vi meget mere energi og fordi at man får et bedre forhold til sine klassekammerater, som man måske ikke snakker med så tit. Man kan holde til mere og det er vigtigt at få en pause til at tænke så derfor vil vi gerne have flere brain...

Techno-Economic Analysis of BEV Service Providers Offering Battery Swapping Services: Preprint

Energy Technology Data Exchange (ETDEWEB)

Neubauer, J.; Pesaran, A.

2013-03-01

Battery electric vehicles (BEVs) offer the potential to reduce both oil imports and greenhouse gas emissions, but high upfront costs, battery-limited vehicle range, and concern over high battery replacement costs may discourage potential buyers. A subscription model in which a service provider owns the battery and supplies access to battery swapping infrastructure could reduce upfront and replacement costs for batteries with a predictable monthly fee, while expanding BEV range. Assessing the costs and benefits of such a proposal are complicated by many factors, including customer drive patterns, the amount of required infrastructure, battery life, etc. The National Renewable Energy Laboratory has applied its Battery Ownership Model to compare the economics and utility of BEV battery swapping service plan options to more traditional direct ownership options. Our evaluation process followed four steps: (1) identifying drive patterns best suited to battery swapping service plans, (2) modeling service usage statistics for the selected drive patterns, (3) calculating the cost-of-service plan options, and (4) evaluating the economics of individual drivers under realistically priced service plans. A service plan option can be more cost-effective than direct ownership for drivers who wish to operate a BEV as their primary vehicle where alternative options for travel beyond the single-charge range are expensive, and a full-coverage-yet-cost-effective regional infrastructure network can be deployed. However, when assumed cost of gasoline, tax structure, and absence of purchase incentives are factored in, our calculations show the service plan BEV is rarely more cost-effective than direct ownership of a conventional vehicle.

En verden i bevægelse

DEFF Research Database (Denmark)

Brøgger, Ditte Rasmussen

2016-01-01

Migration er ikke noget nyt fænomen, men det er et fænomen i konstant forandring – både kvantitativt og kvalitativt. Mennesker har nemlig altid bevæget sig. Tag f.eks. jæger-samlerfolket, der var cirkulære migranter, størstedelen af USA’s befolkning, som de fleste nok er bekendte med er...

Evaluation of a Novel BEV Concept Based on Fixed and Swappable Li-Ion Battery Packs

DEFF Research Database (Denmark)

Barreras, Jorge Varela; Pinto, Claudio; de Castro, Ricardo

2016-01-01

-based ownership models to distribute the cost of the large battery pack over the vehicle lifetime. A methodology is proposed for the analysis and evaluation of the proposed concept in comparison with a direct owned nonswappable single-pack BEV, proving that significant improvements on city fuel economy (up to 14......In this paper, a novel battery electric vehicle (BEV) concept based on a small fixed and a big swappable Li-ion battery pack is proposed in order to achieve longer range, lower initial purchase priceand lower energy consumption at short ranges. For short ranges, the BEV is only powered...... by the relatively small-fixed battery pack, without the large swappable battery pack. In this way, the mass of the vehicle is reduced and, therefore, the energy consumed per unit distance is improved. For higher ranges, the BEV is powered by both battery packs. This concept allows the introduction of subscription...

Evaluating the TU/e Lupo EL BEV performance

NARCIS (Netherlands)

Besselink, I.J.M.; Wang, J.; Nijmeijer, H.

2013-01-01

The TU/e has developed a battery electric vehicle (BEV) using a VW Lupo 3L as donor platform. The differences between the initial design calculations and actual vehicle performance are analysed. Battery charging and discharging efficiency, acceleration performance and top speed are as expected. The

Motion og bevægelse i skolen

DEFF Research Database (Denmark)

I den første egentlige skolelov i Danmark fra 1814 var det intentionen, at eleverne skulle bevæge sig ”Een Time Dagligen”, som det hed i Anordning for Almue-Skolevæsenet paa Landet i Danmark (XXXX). Mange reformer og skolelove senere blev der i 2014 efter præcis 200 år gjort endnu et forsøg på...

Future mobility case studies. Life cycle assessments of BEVs and ICVs with a global perspective

Energy Technology Data Exchange (ETDEWEB)

Ma, Hongrui; Riera-Palou, Xavier; Tait, Nigel [Shell Global Solutions (United Kingdom), Chester (United Kingdom). Shell Technology Center Thornton; Balthasar, Felix; Warnecke, Wolfgang [Shell Global Solutions (Deutschland) GmbH, Hamburg (Germany). PAE-Labor

2012-11-01

To highlight the potential risks associated with simplification, we present a relevant case study on electric vehicles, where the outcome of the analysis changes substantially with the methodological/system boundary choices made. Electric vehicles have increasingly gained worldwide interest as one of the most promising potential long-term solutions to sustainable personal mobility; in particular, battery electric vehicles (BEVs) offer zero tailpipe emissions enabling them not only to reduce transport GHG emissions but also to reduce other regulated emissions (e.g. smog). However, their true ability to contribute to GHG emissions reductions can only be properly assessed by comparing a full life cycle assessment of their GHG emissions with a similar assessment for conventional internal combustion vehicles (ICVs). In this study, we have carried out an analysis for vehicles typical of those expected to be introduced in 2012 in Western Europe, the U.S. and China, taking into account the impact of three important factors: (a) like-forlike vehicle comparison and effect of real-world driving conditions, (b) accounting for the GHG emissions associated with meeting the additional electricity demand for charging the batteries, and (c) the GHG emissions associated with the vehicle life cycle (e.g. manufacture and disposal, etc). We find that BEVs can deliver significant GHG savings compared to ICVs providing that the grid GHG intensity used to charge the batteries is sufficiently low. In particular, BEVs perform best relative to ICVs in terms of GHG emissions in low speed (e.g. urban) driving and when lightly loaded with weight and auxiliaries. However, vehicle life cycle emissions are higher for BEVs than ICVs due to the GHG emissions associated with battery manufacture. Furthermore, our analysis illustrates that it is inappropriate to draw general conclusions about the relative GHG performance of BEVs and ICVs without due reference to the context - such relative performance

Karakterstyrker, mindfulness og bevægelse i børnehave og skole

DEFF Research Database (Denmark)

Rasmussen, Kristian; Feldt-Rasmussen, Sanne; Ottesen, Claus Løgstrup

2017-01-01

Artiklen beskriver, hvordan man via arbejdet med karakterstyrker, mindfulness og bevægelsesaktiviteter kan skabe inkluderende læringsmiljøer i børnehave og skole. Kapitlet tager udgangspunkt i forskningsprojektet KaMiBe, som er gennemført på udvalgte børnehaver og skoler i Haderslev Kommune i...... skoleåret 2015-2016. Kapitlet redegør for projektets teoretiske forankring og giver eksempler på konkrete aktiviteter inden for mindfulness, bevægelse, herunder yoga, med afsæt i arbejdet med karakterstyrker. KaMiBe-projektet har vist gode resultater i form af markante forbedringer af det sociale miljø i...

Roles of silkworm endoplasmic reticulum chaperones in the secretion of recombinant proteins expressed by baculovirus system.

Science.gov (United States)

Imai, Saki; Kusakabe, Takahiro; Xu, Jian; Li, Zhiqing; Shirai, Shintaro; Mon, Hiroaki; Morokuma, Daisuke; Lee, Jae Man

2015-11-01

Baculovirus expression vector system (BEVS) is widely used for production of recombinant eukaryotic proteins in insect larvae or cultured cells. BEVS has advantages over bacterial expression system in producing post-translationally modified secreted proteins. However, for some unknown reason, it is very difficult for insects to secrete sufficiently for certain proteins of interest. To understand the reasons why insect cells fail to secrete some kinds of recombinant proteins, we here employed three mammalian proteins as targets, EPO, HGF, and Wnt3A, with different secretion levels in BEVS and investigated their mRNA transcriptions from the viral genome, subcellular localizations, and interactions with silkworm ER chaperones. Moreover, we observed that no significantly influence on the secretion amounts of all three proteins when depleting or overexpressing most endogenous ER chaperone genes in cultured silkworm cells. However, among all detected ER chaperones, the depletion of BiP severely decreased the recombinant protein secretion in BEVS, indicating the possible central role of Bip in silkworm secretion pathway.

The Influence of SV40 polyA on Gene Expression of Baculovirus Expression Vector Systems.

Directory of Open Access Journals (Sweden)

Tamer Z Salem

Full Text Available The simian virus 40 polyadenylation signal (SV40 polyA has been routinely inserted downstream of the polyhedrin promoter in many baculovirus expression vector systems (BEVS. In the baculovirus prototype Autographa californica multiple nucleopolyhedrovirus (AcMNPV, the polyhedrin promoter (very late promoter transcribes its gene by a viral RNA polymerase therefore there is no supporting evidence that SV40 polyA is required for the proper gene expression under the polyhedrin promoter. Moreover, the effect of the SV40 polyA sequence on the polyhedrin promoter activity has not been tested either at its natural polyhedrin locus or in other loci in the viral genome. In order to test the significance of adding the SV40 polyA sequence on gene expression, the expression of the enhanced green fluorescent protein (egfp was evaluated with and without the presence of SV40 polyA under the control of the polyhedrin promoter at different genomic loci (polyherin, ecdysteroid UDP-glucosyltransferase (egt, and gp37. In this study, spectrofluorometry and western blot showed reduction of EGFP protein for all recombinant viruses with SV40 polyA, whereas qPCR showed an increase in the egfp mRNA levels. Therefore, we conclude that SV40 polyA increases mRNA levels but decreases protein production in the BEVS when the polyhedrin promoter is used at different loci. This work suggests that SV40 polyA in BEVSs should be replaced by an AcMNPV late gene polyA for optimal protein production or left untouched for optimal RNA production (RNA interference applications.

The Influence of SV40 polyA on Gene Expression of Baculovirus Expression Vector Systems

Science.gov (United States)

Salem, Tamer Z.; Seaborn, Craig P.; Turney, Colin M.; Xue, Jianli; Shang, Hui; Cheng, Xiao-Wen

2015-01-01

The simian virus 40 polyadenylation signal (SV40 polyA) has been routinely inserted downstream of the polyhedrin promoter in many baculovirus expression vector systems (BEVS). In the baculovirus prototype Autographa californica multiple nucleopolyhedrovirus (AcMNPV), the polyhedrin promoter (very late promoter) transcribes its gene by a viral RNA polymerase therefore there is no supporting evidence that SV40 polyA is required for the proper gene expression under the polyhedrin promoter. Moreover, the effect of the SV40 polyA sequence on the polyhedrin promoter activity has not been tested either at its natural polyhedrin locus or in other loci in the viral genome. In order to test the significance of adding the SV40 polyA sequence on gene expression, the expression of the enhanced green fluorescent protein (egfp) was evaluated with and without the presence of SV40 polyA under the control of the polyhedrin promoter at different genomic loci (polyherin, ecdysteroid UDP-glucosyltransferase (egt), and gp37). In this study, spectrofluorometry and western blot showed reduction of EGFP protein for all recombinant viruses with SV40 polyA, whereas qPCR showed an increase in the egfp mRNA levels. Therefore, we conclude that SV40 polyA increases mRNA levels but decreases protein production in the BEVS when the polyhedrin promoter is used at different loci. This work suggests that SV40 polyA in BEVSs should be replaced by an AcMNPV late gene polyA for optimal protein production or left untouched for optimal RNA production (RNA interference applications). PMID:26659470

MAGNETIC SPECTROMETER DESIGN FOR ELECTRON SCATTERING ABOVE 1 Bev

Energy Technology Data Exchange (ETDEWEB)

Schopper, H.

1963-06-15

Design considerations are discussed for magnetic spectrometer electron scattering investigations with the higher energy (above 1 Bev) electron sources which are being developed. The spectrometers are to be used to discriminate between elastic and inelastic processes. A momentum resolution of the order of one per cent is required for these experiments. Various spectrometers are compared according to their optical properties and the number of magnets they consist of. (R.E.U.)

Extending the Range of a BEV - Early Progress

Energy Technology Data Exchange (ETDEWEB)

Meyer, John; Agathocleous, Nicos; Kang, SH; Vespa, Tony

2015-09-30

The 2015 BEV Kia Soul is available with either a Positive Temperature Coefficient (PTC) heater only or an air-source R134a heat pump with PTC heater combination. Hanon, HATCI, and NREL are jointly, with financial support from the DoE, working towards extending the driving range of the heat pump vehicle. This presentation will focus on the early findings of the project, including test data of the baseline vehicle, early data from a modified vehicle, and range extension goals of the project.

Raster images vectorization system

OpenAIRE

Genytė, Jurgita

2006-01-01

The problem of raster images vectorization was analyzed and researched in this work. Existing vectorization systems are quite expensive, the results are inaccurate, and the manual vectorization of a large number of drafts is impossible. That‘s why our goal was to design and develop a new raster images vectorization system using our suggested automatic vectorization algorithm and the way to record results in a new universal vectorial file format. The work consists of these main parts: analysis...

Karakterstyrker, mindfulness og bevægelse - en vej til inkluderende læringsmiljøer

DEFF Research Database (Denmark)

Feldt-Rasmussen, Sanne; Rasmussen, Kristian; Ottesen, Claus Løgstrup

2017-01-01

Kapitlet beskriver, hvordan man via arbejdet med karakterstyrker, mindfulness og bevægelsesaktiviteter kan skabe inkluderende læringsmiljøer i skolen. I kapitlet giver vi først en kort teoretisk indføring i begreberne, hvorefter vi gennemgår en række praktiske øvelser, som er blevet udviklet og...

Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system

International Nuclear Information System (INIS)

Kajikawa, Mizuho; Sasaki, Kaori; Wakimoto, Yoshitaro; Toyooka, Masaru; Motohashi, Tomoko; Shimojima, Tsukasa; Takeda, Shigeki; Park, Enoch Y.; Maenaka, Katsumi

2009-01-01

Guanine nucleotide-binding protein (G protein) coupled receptors (GPCRs) are frequently expressed by a baculovirus expression vector system (BEVS). We recently established a novel BEVS using the bacmid system of Bombyx mori nucleopolyhedrovirus (BmNPV), which is directly applicable for protein expression in silkworms. Here, we report the first example of GPCR expression in silkworms by the simple injection of BmNPV bacmid DNA. Human nociceptin receptor, an inhibitory GPCR, and its fusion protein with inhibitory G protein alpha subunit (G i α) were both successfully expressed in the fat bodies of silkworm larvae as well as in the BmNPV viral fraction. Its yield was much higher than that from Sf9 cells. The microsomal fractions including the nociceptin receptor fusion, which are easily prepared by only centrifugation steps, exhibited [ 35 S]GTPγS-binding activity upon specific stimulation by nociceptin. Therefore, this rapid method is easy-to-use and has a high expression level, and thus will be an important tool for human GPCR production.

100 år i bevægelse

DEFF Research Database (Denmark)

Jacobsen, Kurt

Fysioterapi er i dag en anerkendt del af det danske sundhedsvæsen. Fysioterapeuter behandler årligt omkring 700.000 patienter på sygehuse, i kommuner og privat praksis, og har ph.d.-grader, er professorer og udfører forskning på højeste internationale niveau. Sådan har det ikke altid været...... havde fra begyndelsen en stærk standsfølelse, og i 100 år i bevægelse fortælles første gang historien om, hvorledes de satte en udvikling gang, der kom til at præge det danske sundhedsvæsen og vores forståelse af sundhed. I årtier kæmpede massøserne for anerkendelse som faggruppe, inden de i 1952 kunne...... kalde sig fysioterapeuter. De kæmpede med lægerne om kontrollen over faget, til de i 1968 fik statsautorisation. De kæmpede for en akademisk uddannelse, som de fik i 2002, og for retten til på egen hånd at stille diagnoser og behandle patienter, hvilket først blev en realitet så sent som i 2007. 100 år...

Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system

Energy Technology Data Exchange (ETDEWEB)

Kajikawa, Mizuho; Sasaki, Kaori [Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 (Japan); Wakimoto, Yoshitaro; Toyooka, Masaru [Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan); Motohashi, Tomoko; Shimojima, Tsukasa [National Institute of Genetics, 1111 Yata, Mishima, Shizuoka 411-8540 (Japan); Takeda, Shigeki [Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan); Park, Enoch Y. [Laboratory of Biotechnology, Integrated Bioscience Section, Graduate School of Science and Technology, Shizuoka University, 836 Oya, Suruga-ku, Shizuoka, Shizuoka 422-8529 (Japan); Maenaka, Katsumi, E-mail: kmaenaka-umin@umin.net [Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582 (Japan)

2009-07-31

Guanine nucleotide-binding protein (G protein) coupled receptors (GPCRs) are frequently expressed by a baculovirus expression vector system (BEVS). We recently established a novel BEVS using the bacmid system of Bombyx mori nucleopolyhedrovirus (BmNPV), which is directly applicable for protein expression in silkworms. Here, we report the first example of GPCR expression in silkworms by the simple injection of BmNPV bacmid DNA. Human nociceptin receptor, an inhibitory GPCR, and its fusion protein with inhibitory G protein alpha subunit (G{sub i}{alpha}) were both successfully expressed in the fat bodies of silkworm larvae as well as in the BmNPV viral fraction. Its yield was much higher than that from Sf9 cells. The microsomal fractions including the nociceptin receptor fusion, which are easily prepared by only centrifugation steps, exhibited [{sup 35}S]GTP{gamma}S-binding activity upon specific stimulation by nociceptin. Therefore, this rapid method is easy-to-use and has a high expression level, and thus will be an important tool for human GPCR production.

Chapter 15. transforming lepidopteran insect cells for continuous recombinant protein expression

Science.gov (United States)

The baculovirus expression vector system (BEVS) is widely used to produce large quantities of recombinant proteins. However, yields of extracellular and membrane-bound proteins obtained with this system often are very low, possibly due to the adverse effects of baculovirus infection on the host ins...

Comparison of the air-kerma standards of the BEV and the BIPM in the low-energy X-ray range

International Nuclear Information System (INIS)

Burns, D.T.; Witzani, J.

2002-09-01

A direct comparison has been made between the air-kerma standards of the BEV and the BIPM in the low-energy x-ray range. The results at the different radiation qualities show the standards to be in reasonable agreement with respect to the combined relative standard uncertainty of the comparison of 2.4 x 10 -3 . (authors)

Result of the intercomparison exercise on radon measuring instruments and radon detectors 'bev- radon ring 2005'

International Nuclear Information System (INIS)

Baumgartner, A.; Maringer, F.J.; Michai, P.; Kreuziger, M.

2006-01-01

In spring 2005 the Federal Office of Metrology and Surveying (B.E.V.) invited all in Austria working radon measuring institutes to an intercomparison exercise at the radon calibration laboratory in the Arsenal. The aim of this intercomparison was on the one hand an objective inquiry and documentation of the current metrological potential on the section of radon measurement in Austria - both quantitative and qualitative- and on the other hand an initiative for the participating laboratories to optimize and improve their applied calibration-, measurement and analyse technique. Ten contacted Austrian radon laboratories were prepared to participate on the radon intercomparison exercise. The intercomparison exercise was carried out from 14. till 29. June at the radon calibration laboratory in the Arsenal of the B.E.V.. As radon emanation source a five stepped arranged, at the Arsenal built radon source was used. The source ( A.D.O.T.T.O. 1 is filled with a certified Ra- 226-standard solution of the Czech Metrological Institute (C.M.I.), Prag. A simple statistic based model was used for the evaluation and assessment of the results from the participants, which consider the statistic nature of the radioactive decay combined uncertainty. Altogether 183 measuring instruments participated the intercomparison exercise. Two reference measuring instruments, 22 active and 159 passive measuring instruments. The active measuring instruments formed 6 types of instruments and as passive radon detectors were 7 different types used from the participants. The positioning of the radon measuring instruments and detectors in the radon calibration laboratory was executed in regard to statistic points of view. From the active measuring instruments 17 could qualify and from the passive methods six from eight participants were in compliance to the given criteria. Radon measurements, which could have financial and economics relating implications (e.g. architectural redevelopment or

An introduction to vectors, vector operators and vector analysis

CERN Document Server

Joag, Pramod S

2016-01-01

Ideal for undergraduate and graduate students of science and engineering, this book covers fundamental concepts of vectors and their applications in a single volume. The first unit deals with basic formulation, both conceptual and theoretical. It discusses applications of algebraic operations, Levi-Civita notation, and curvilinear coordinate systems like spherical polar and parabolic systems and structures, and analytical geometry of curves and surfaces. The second unit delves into the algebra of operators and their types and also explains the equivalence between the algebra of vector operators and the algebra of matrices. Formulation of eigen vectors and eigen values of a linear vector operator are elaborated using vector algebra. The third unit deals with vector analysis, discussing vector valued functions of a scalar variable and functions of vector argument (both scalar valued and vector valued), thus covering both the scalar vector fields and vector integration.

A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure

NARCIS (Netherlands)

Antonis, A.F.G.; Bruschke, C.J.M.; Rueda, P.; Maranga, L.; Casal, J.; Vela, C.; Hilgers, L.A.T.; Belt, P.B.G.M.; Weerdmeester, K.; Carrondo, M.J.; Langeveld, J.P.M.

2006-01-01

A novel vaccine against porcine parvovirus (PPV), composed of recombinant virus-like particles (PPV-VLPs) produced with the baculovirus expression vector system (BEVS) at industrial scale, was tested for its immunogenicity and protective potency. A formulation of submicrogram amounts of PPV-VLPs in

Da fusão Antárctica/Brahma à fusão com a Interbrew: uma análise da trajetória econômico-financeira e estratégica da AmBev AmBev from the merger of Antarctica and Brahma to the merger with Interbrew: an analysis of financial, economic and strategic progress

Directory of Open Access Journals (Sweden)

Marcos Antônio de Camargos

2005-09-01

Full Text Available Criada em julho de 1999, resultante da controversa união entre as duas principais concorrentes no segmento de bebidas brasileiro - a Antárctica e a Brahma -, a AmBev, com uma gestão moderna, eficiente, voltada para resultados a curto prazo e com um controle gerencial compartilhado entre os principais executivos das duas empresas de origem, tornou-se em menos de cinco anos uma das empresas mais admiradas e bem administradas do cenário empresarial brasileiro e latino-americano. Fundamentado na teoria das fusões e aquisições, este artigo faz uma análise da trajetória da AmBev, no que se refere a seus aspectos econômico-financeiros e estratégicos, desde a sua criação até a sua fusão com a Interbrew, cuja concretização resultou em mudanças significativas para ambas e para o segmento de bebidas nacional e internacional, visto que se trata da união de empresas líderes ou vice-líderes no segmento de cervejas em diversos países e que atuam em mercados mundiais complementares.AmBev rapidly became a well managed company, one of the most admired in Brazil and on the continent. This was in less than five years after its structure in July of 1999 with the controversial merger between Antarctica and Brahma, the two main competitors in the beverage industry. This prominence was the result of modern and efficient management focused on short term results and control shared by the top executives of both Antarctica and Brahma. An analysis was made of the financial, economic and strategic progress of AmBev from the beginning up to the merger with Interbrew, using the Theory of Mergers and Acquisitions. After this merger both participants will undergo significant changes as will the national and international beverage segments where they enjoyed first and second places in the beer segment of several countries in addition to participating in complementary world markets.

High-speed vector-processing system of the MELCOM-COSMO 900II

Energy Technology Data Exchange (ETDEWEB)

Masuda, K; Mori, H; Fujikake, J; Sasaki, Y

1983-01-01

Progress in scientific and technical calculations has lead to a growing demand for high-speed vector calculations. Mitsubishi electric has developed an integrated array processor and automatic-vectorizing fortran compiler as an option for the MELCOM-COSMO 900II computer system. This facilitates the performance of vector calculations and matrix calculations, achieving significant gains in cost-effectiveness. The article outlines the high-speed vector system, includes discussion of compiler structuring, and cites examples of effective system application. 1 reference.

An improved ternary vector system for Agrobacterium-mediated rapid maize transformation.

Science.gov (United States)

Anand, Ajith; Bass, Steven H; Wu, Emily; Wang, Ning; McBride, Kevin E; Annaluru, Narayana; Miller, Michael; Hua, Mo; Jones, Todd J

2018-05-01

A simple and versatile ternary vector system that utilizes improved accessory plasmids for rapid maize transformation is described. This system facilitates high-throughput vector construction and plant transformation. The super binary plasmid pSB1 is a mainstay of maize transformation. However, the large size of the base vector makes it challenging to clone, the process of co-integration is cumbersome and inefficient, and some Agrobacterium strains are known to give rise to spontaneous mutants resistant to tetracycline. These limitations present substantial barriers to high throughput vector construction. Here we describe a smaller, simpler and versatile ternary vector system for maize transformation that utilizes improved accessory plasmids requiring no co-integration step. In addition, the newly described accessory plasmids have restored virulence genes found to be defective in pSB1, as well as added virulence genes. Testing of different configurations of the accessory plasmids in combination with T-DNA binary vector as ternary vectors nearly doubles both the raw transformation frequency and the number of transformation events of usable quality in difficult-to-transform maize inbreds. The newly described ternary vectors enabled the development of a rapid maize transformation method for elite inbreds. This vector system facilitated screening different origins of replication on the accessory plasmid and T-DNA vector, and four combinations were identified that have high (86-103%) raw transformation frequency in an elite maize inbred.

Lyapunov, singular and bred vectors in a multi-scale system: an empirical exploration of vectors related to instabilities

International Nuclear Information System (INIS)

Norwood, Adrienne; Kalnay, Eugenia; Ide, Kayo; Yang, Shu-Chih; Wolfe, Christopher

2013-01-01

We compute and compare the three types of vectors frequently used to explore the instability properties of dynamical models, namely Lyapunov vectors (LVs), singular vectors (SVs) and bred vectors (BVs) in two systems, using the Wolfe–Samelson (2007 Tellus A 59 355–66) algorithm to compute all of the Lyapunov vectors. The first system is the Lorenz (1963 J. Atmos. Sci. 20 130–41) three-variable model. Although the leading Lyapunov vector, LV1, grows fastest globally, the second Lyapunov vector, LV2, which has zero growth globally, often grows faster than LV1 locally. Whenever this happens, BVs grow closer to LV2, suggesting that in larger atmospheric or oceanic models where several instabilities can grow in different areas of the world, BVs will grow toward the fastest growing local unstable mode. A comparison of their growth rates at different times shows that all three types of dynamical vectors have the ability to predict regime changes and the duration of the new regime based on their growth rates in the last orbit of the old regime, as shown for BVs by Evans et al (2004 Bull. Am. Meteorol. Soc. 520–4). LV1 and BVs have similar predictive skill, LV2 has a tendency to produce false alarms, and even LV3 shows that maximum decay is also associated with regime change. Initial and final SVs grow much faster and are the most accurate predictors of regime change, although the characteristics of the initial SVs are strongly dependent on the length of the optimization window. The second system is the toy ‘ocean-atmosphere’ model developed by Peña and Kalnay (2004 Nonlinear Process. Geophys. 11 319–27) coupling three Lorenz (1963 J. Atmos. Sci. 20 130–41) systems with different time scales, in order to test the effects of fast and slow modes of growth on the dynamical vectors. A fast ‘extratropical atmosphere’ is weakly coupled to a fast ‘tropical atmosphere’ which is, in turn, strongly coupled to a slow ‘ocean’ system, the latter coupling

Result of the intercomparison exercise on radon measuring instruments and radon detectors 'bev- radon ring 2005'

Energy Technology Data Exchange (ETDEWEB)

Baumgartner, A. [Vienna Univ. of Technology, Atominstitut, Wien (Austria); Maringer, F.J.; Michai, P.; Kreuziger, M. [BEV-Federal Office of Metrology and Surveying, Wien (Austria)

2006-07-01

In spring 2005 the Federal Office of Metrology and Surveying (B.E.V.) invited all in Austria working radon measuring institutes to an intercomparison exercise at the radon calibration laboratory in the Arsenal. The aim of this intercomparison was on the one hand an objective inquiry and documentation of the current metrological potential on the section of radon measurement in Austria - both quantitative and qualitative- and on the other hand an initiative for the participating laboratories to optimize and improve their applied calibration-, measurement and analyse technique. Ten contacted Austrian radon laboratories were prepared to participate on the radon intercomparison exercise. The intercomparison exercise was carried out from 14. till 29. June at the radon calibration laboratory in the Arsenal of the B.E.V.. As radon emanation source a five stepped arranged, at the Arsenal built radon source was used. The source ( A.D.O.T.T.O. 1 is filled with a certified Ra- 226-standard solution of the Czech Metrological Institute (C.M.I.), Prag. A simple statistic based model was used for the evaluation and assessment of the results from the participants, which consider the statistic nature of the radioactive decay combined uncertainty. Altogether 183 measuring instruments participated the intercomparison exercise. Two reference measuring instruments, 22 active and 159 passive measuring instruments. The active measuring instruments formed 6 types of instruments and as passive radon detectors were 7 different types used from the participants. The positioning of the radon measuring instruments and detectors in the radon calibration laboratory was executed in regard to statistic points of view. From the active measuring instruments 17 could qualify and from the passive methods six from eight participants were in compliance to the given criteria. Radon measurements, which could have financial and economics relating implications (e.g. architectural redevelopment or

System for Automated Calibration of Vector Modulators

Science.gov (United States)

Lux, James; Boas, Amy; Li, Samuel

2009-01-01

Vector modulators are used to impose baseband modulation on RF signals, but non-ideal behavior limits the overall performance. The non-ideal behavior of the vector modulator is compensated using data collected with the use of an automated test system driven by a LabVIEW program that systematically applies thousands of control-signal values to the device under test and collects RF measurement data. The technology innovation automates several steps in the process. First, an automated test system, using computer controlled digital-to-analog converters (DACs) and a computer-controlled vector network analyzer (VNA) systematically can apply different I and Q signals (which represent the complex number by which the RF signal is multiplied) to the vector modulator under test (VMUT), while measuring the RF performance specifically, gain and phase. The automated test system uses the LabVIEW software to control the test equipment, collect the data, and write it to a file. The input to the Lab - VIEW program is either user-input for systematic variation, or is provided in a file containing specific test values that should be fed to the VMUT. The output file contains both the control signals and the measured data. The second step is to post-process the file to determine the correction functions as needed. The result of the entire process is a tabular representation, which allows translation of a desired I/Q value to the required analog control signals to produce a particular RF behavior. In some applications, corrected performance is needed only for a limited range. If the vector modulator is being used as a phase shifter, there is only a need to correct I and Q values that represent points on a circle, not the entire plane. This innovation has been used to calibrate 2-GHz MMIC (monolithic microwave integrated circuit) vector modulators in the High EIRP Cluster Array project (EIRP is high effective isotropic radiated power). These calibrations were then used to create

Battery Electric Vehicle (BEV or Range Extended Electric Vehicle (REEV? —Deciding Between Different Alternative Drives Based on Measured Individual Operational Profiles Véhicule électrique à batteries (BEV ou véhicule électrique à prolongateur d’autonomie (REEV ? — Choisir entre différents entraînements alternatifs sur la base de profils opérationnels individuels mesurés

Directory of Open Access Journals (Sweden)

Marker S.

2013-05-01

Full Text Available In recent years, a large number of concepts for drive train electrification and a corresponding broad variety of available drive train configurations were presented to the public. They all have their pros and cons for the customer. This paper discusses a tool enabling the customer to select the drive train which is best suited to his individual purposes. The presented approach focuses on BEV and REEV and is characterized by a three-step procedure: the customer’s individual driving behaviour is measured: individualized driving cycles and operational habits including the daily kilometrage are derived; numerical models of the alternative drive train concepts are run to simulate the energy consumption by applying these individualized cycles. The study reveals that battery sizing is the most important component. It would be more efficient to use a REEV with a smaller battery instead of a BEV: at a given range of 50 km the BEV covers 50% of the kilometers (corresponding to 90% of all daily distances while the REEV covers 100% of all daily distances, out of it 70% on electric driving. This leads to less CO2 emission compared to the combined use of BEV and conventional cars. The REEV with the smallest battery is amortized first referred to conventional cars. The influence of the individual usage pattern can be translated to operational costs. The REEV urban driver covers 85% by electric driving and has thus lower operational costs than the REEV inter-urban driver with 64% electric driving. Récemment, un grand nombre de concepts d’électrification des groupes motopropulseurs et une large variété correspondante de configurations disponibles ont été présentés au public. Tous possèdent des avantages et des inconvénients pour le client. Cet article traite d’un outil permettant au client de sélectionner le groupe motopropulseur le plus adapté à ses besoins individuels. L’approche présentée se focalise sur les véhicules BEV (Battery

Genetic modification of neurons to express bevacizumab for local anti-angiogenesis treatment of glioblastoma.

Science.gov (United States)

Hicks, Martin J; Funato, Kosuke; Wang, Lan; Aronowitz, Eric; Dyke, Jonathan P; Ballon, Douglas J; Havlicek, David F; Frenk, Esther Z; De, Bishnu P; Chiuchiolo, Maria J; Sondhi, Dolan; Hackett, Neil R; Kaminsky, Stephen M; Tabar, Viviane; Crystal, Ronald G

2015-01-01

The median survival of glioblastoma multiforme (GBM) is approximately 1 year. Following surgical removal, systemic therapies are limited by the blood-brain barrier. To circumvent this, we developed a method to modify neurons with the genetic sequence for therapeutic monoclonal antibodies using adeno-associated virus (AAV) gene transfer vectors, directing persistent, local expression in the tumor milieu. The human U87MG GBM cell line or patient-derived early passage GBM cells were administered to the striatum of NOD/SCID immunodeficient mice. AAVrh.10BevMab, an AAVrh.10-based vector coding for bevacizumab (Avastin), an anti-human vascular endothelial growth factor (VEGF) monoclonal antibody, was delivered to the area of the GBM xenograft. Localized expression of bevacizumab was demonstrated by quantitative PCR, ELISA and western blotting. Immunohistochemistry showed that bevacizumab was expressed in neurons. Concurrent administration of AAVrh.10BevMab with the U87MG tumor reduced tumor blood vessel density and tumor volume, and increased survival. Administration of AAVrh.10BevMab 1 week after U87MG xenograft reduced growth and increased survival. Studies with patient-derived early passage GBM primary cells showed a reduction in primary tumor burden with an increased survival. These data support the strategy of AAV-mediated central nervous system gene therapy to treat GBM, overcoming the blood-brain barrier through local, persistent delivery of an anti-angiogenesis monoclonal antibody.

Vectorization, parallelization and porting of nuclear codes on the VPP500 system (vectorization). Progress report fiscal 1997

International Nuclear Information System (INIS)

Kawasaki, Nobuo; Ogasawara, Shinobu; Adachi, Masaaki; Kume, Etsuo; Ishizuki, Shigeru; Tanabe, Hidenobu; Nemoto, Toshiyuki; Kawai, Wataru; Watanabe, Hideo

1999-05-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system and/or the AP3000 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 14 codes in fiscal 1997. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the vectorization. In this vectorization part, the vectorization of multidimensional two-fluid model code ACE-3D for evaluation of constitutive equations, statistical decay code SD and three-dimensional thermal analysis code for in-core test section (T2) of HENDEL SSPHEAT are described. In the parallelization part, the parallelization of cylindrical direct numerical simulation code CYLDNS44N, worldwide version of system for prediction of environmental emergency dose information code WSPEEDI, extension of quantum molecular dynamics code EQMD and three-dimensional non-steady compressible fluid dynamics code STREAM are described. In the porting part, the porting of transient reactor analysis code TRAC-BF1 and Monte Carlo radiation transport code MCNP4A on the AP3000 are described. In addition, a modification of program libraries for command-driven interactive data analysis plotting program IPLOT is described. (author)

Vectorization, parallelization and porting of nuclear codes on the VPP500 system (vectorization). Progress report fiscal 1996

Energy Technology Data Exchange (ETDEWEB)

Nemoto, Toshiyuki; Kawai, Wataru [Fujitsu Ltd., Tokyo (Japan); Kawasaki, Nobuo [and others

1997-12-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the vectorization. In this vectorization part, the vectorization of two and three dimensional discrete ordinates simulation code DORT-TORT, gas dynamics analysis code FLOWGR and relativistic Boltzmann-Uehling-Uhlenbeck simulation code RBUU are described. In the parallelization part, the parallelization of 2-Dimensional relativistic electromagnetic particle code EM2D, Cylindrical Direct Numerical Simulation code CYLDNS and molecular dynamics code for simulating radiation damages in diamond crystals DGR are described. And then, in the porting part, the porting of reactor safety analysis code RELAP5/MOD3.2 and RELAP5/MOD3.2.1.2, nuclear data processing system NJOY and 2-D multigroup discrete ordinate transport code TWOTRAN-II are described. And also, a survey for the porting of command-driven interactive data analysis plotting program IPLOT are described. (author)

Expression of polyhedrin-hEGF fusion protein in cultured cells and ...

African Journals Online (AJOL)

For mass production of human epidermal growth factor (hEGF), silkworm baculovirus expression vector system (BEVS) was adopted in this study. hEGF gene was in-frame fused with polyhedrin (Ph) gene under the control of Ph promoter and was used to co-transfect BmN cell with the modified. Bombyx mori baculovirus ...

Generalized decompositions of dynamic systems and vector Lyapunov functions

Science.gov (United States)

Ikeda, M.; Siljak, D. D.

1981-10-01

The notion of decomposition is generalized to provide more freedom in constructing vector Lyapunov functions for stability analysis of nonlinear dynamic systems. A generalized decomposition is defined as a disjoint decomposition of a system which is obtained by expanding the state-space of a given system. An inclusion principle is formulated for the solutions of the expansion to include the solutions of the original system, so that stability of the expansion implies stability of the original system. Stability of the expansion can then be established by standard disjoint decompositions and vector Lyapunov functions. The applicability of the new approach is demonstrated using the Lotka-Volterra equations.

Stability and Control of Large-Scale Dynamical Systems A Vector Dissipative Systems Approach

CERN Document Server

Haddad, Wassim M

2011-01-01

Modern complex large-scale dynamical systems exist in virtually every aspect of science and engineering, and are associated with a wide variety of physical, technological, environmental, and social phenomena, including aerospace, power, communications, and network systems, to name just a few. This book develops a general stability analysis and control design framework for nonlinear large-scale interconnected dynamical systems, and presents the most complete treatment on vector Lyapunov function methods, vector dissipativity theory, and decentralized control architectures. Large-scale dynami

High performance computing on vector systems

CERN Document Server

Roller, Sabine

2008-01-01

Presents the developments in high-performance computing and simulation on modern supercomputer architectures. This book covers trends in hardware and software development in general and specifically the vector-based systems and heterogeneous architectures. It presents innovative fields like coupled multi-physics or multi-scale simulations.

Large-scale production of lentiviral vector in a closed system hollow fiber bioreactor

Directory of Open Access Journals (Sweden)

Jonathan Sheu

Full Text Available Lentiviral vectors are widely used in the field of gene therapy as an effective method for permanent gene delivery. While current methods of producing small scale vector batches for research purposes depend largely on culture flasks, the emergence and popularity of lentiviral vectors in translational, preclinical and clinical research has demanded their production on a much larger scale, a task that can be difficult to manage with the numbers of producer cell culture flasks required for large volumes of vector. To generate a large scale, partially closed system method for the manufacturing of clinical grade lentiviral vector suitable for the generation of induced pluripotent stem cells (iPSCs, we developed a method employing a hollow fiber bioreactor traditionally used for cell expansion. We have demonstrated the growth, transfection, and vector-producing capability of 293T producer cells in this system. Vector particle RNA titers after subsequent vector concentration yielded values comparable to lentiviral iPSC induction vector batches produced using traditional culture methods in 225 cm2 flasks (T225s and in 10-layer cell factories (CF10s, while yielding a volume nearly 145 times larger than the yield from a T225 flask and nearly three times larger than the yield from a CF10. Employing a closed system hollow fiber bioreactor for vector production offers the possibility of manufacturing large quantities of gene therapy vector while minimizing reagent usage, equipment footprint, and open system manipulation.

Expression and Characterization of Human β-1, 4-Galactosyltransferase 1 (β4GalT1) Using Silkworm–Baculovirus Expression System

KAUST Repository

Morokuma, Daisuke

2017-03-24

Baculovirus expression vector system (BEVS) is widely known as a mass-production tool to produce functional recombinant glycoproteins except that it may not be always suitable for medical practice due to the differences in the structure of N-linked glycans between insects and mammalian. Currently, various approaches have been reported to alter N-linked glycan structures of glycoproteins derived from insects into terminally sialylated complex-type N-glycans. In the light of those studies, we also proposed in vitro maturation of N-glycan with mass-produced and purified glycosyltransferases by silkworm–BEVS. β-1,4-Galactosyltransferase 1 (β4GalT1) is known as one of type II transmembrane enzymes that transfer galactose in a β-1, 4 linkage to accepter sugars, and a key enzyme for further sialylation of N-glycans. In this study, we developed a large-scale production of recombinant human β4GalT1 (rhβ4GalT1) with N- or C-terminal tags in silkworm–BEVS. We demonstrated that rhβ4GalT1 is N-glycosylated and without mucin-type glycosylation. Interestingly, we found that purified rhβ4GalT1 from silkworm serum presented higher galactosyltransferase activity than that expressed from cultured mammalian cells. We also validated the UDP-galactose transferase activity of produced rhβ4GalT1 proteins by using protein subtracts from silkworm silk gland. Taken together, rhβ4GalT1 from silkworms can become a valuable tool for producing high-quality recombinant glycoproteins with mammalian-like N-glycans.

Linear Matrix Inequalities for Analysis and Control of Linear Vector Second-Order Systems

DEFF Research Database (Denmark)

Adegas, Fabiano Daher; Stoustrup, Jakob

2015-01-01

the Lyapunov matrix and the system matrices by introducing matrix multipliers, which potentially reduce conservativeness in hard control problems. Multipliers facilitate the usage of parameter-dependent Lyapunov functions as certificates of stability of uncertain and time-varying vector second-order systems......SUMMARY Many dynamical systems are modeled as vector second-order differential equations. This paper presents analysis and synthesis conditions in terms of LMI with explicit dependence in the coefficient matrices of vector second-order systems. These conditions benefit from the separation between....... The conditions introduced in this work have the potential to increase the practice of analyzing and controlling systems directly in vector second-order form. Copyright © 2014 John Wiley & Sons, Ltd....

Reversible Vector Ratchet Effect in Skyrmion Systems

Science.gov (United States)

Ma, Xiaoyu; Reichhardt, Charles; Reichhardt, Cynthia

Magnetic skyrmions are topological non-trivial spin textures found in several magnetic materials. Since their motion can be controlled using ultralow current densities, skyrmions are appealing for potential applications in spintronics as information carriers and processing devices. In this work, we studied the collective transport properties of driven skyrmions based on a particle-like model with molecular dynamics (MD) simulation. Our results show that ac driven skyrmions interacting with an asymmetric substrate provide a realization of a new class of ratchet system, which we call a vector ratchet, that arises due to the effect of the Magnus term on the skyrmion dynamics. In a vector ratchet, the dc motion induced by the ac drive can be described as a vector that can be rotated up to 360 degrees relative to the substrate asymmetry direction. This could represent a new method for controlling skyrmion motion for spintronic applications.

Managing the resilience space of the German energy system - A vector analysis.

Science.gov (United States)

Schlör, Holger; Venghaus, Sandra; Märker, Carolin; Hake, Jürgen-Friedrich

2018-07-15

The UN Sustainable Development Goals formulated in 2016 confirmed the sustainability concept of the Earth Summit of 1992 and supported UNEP's green economy transition concept. The transformation of the energy system (Energiewende) is the keystone of Germany's sustainability strategy and of the German green economy concept. We use ten updated energy-related indicators of the German sustainability strategy to analyse the German energy system. The development of the sustainable indicators is examined in the monitoring process by a vector analysis performed in two-dimensional Euclidean space (Euclidean plane). The aim of the novel vector analysis is to measure the current status of the Energiewende in Germany and thereby provide decision makers with information about the strains for the specific remaining pathway of the single indicators and of the total system in order to meet the sustainability targets of the Energiewende. Within this vector model, three vectors (the normative sustainable development vector, the real development vector, and the green economy vector) define the resilience space of our analysis. The resilience space encloses a number of vectors representing different pathways with different technological and socio-economic strains to achieve a sustainable development of the green economy. In this space, the decision will be made as to whether the government measures will lead to a resilient energy system or whether a readjustment of indicator targets or political measures is necessary. The vector analysis enables us to analyse both the government's ambitiousness, which is expressed in the sustainability target for the indicators at the start of the sustainability strategy representing the starting preference order of the German government (SPO) and, secondly, the current preference order of German society in order to bridge the remaining distance to reach the specific sustainability goals of the strategy summarized in the current preference order (CPO

Diagnosis of nutrient imbalances with vector analysis in agroforestry systems.

Science.gov (United States)

Isaac, Marney E; Kimaro, Anthony A

2011-01-01

Agricultural intensification has had unintended environmental consequences, including increased nutrient leaching and surface runoff and other agrarian-derived pollutants. Improved diagnosis of on-farm nutrient dynamics will have the advantage of increasing yields and will diminish financial and environmental costs. To achieve this, a management support system that allows for site-specific rapid evaluation of nutrient production imbalances and subsequent management prescriptions is needed for agroecological design. Vector diagnosis, a bivariate model to depict changes in yield and nutritional response simultaneously in a single graph, facilitates identification of nutritional status such as growth dilution, deficiency, sufficiency, luxury uptake, and toxicity. Quantitative data from cocoa agroforestry systems and pigeonpea intercropping trials in Ghana and Tanzania, respectively, were re-evaluated with vector analysis. Relative to monoculture, biomass increase in cocoa ( L.) under shade (35-80%) was accompanied by a 17 to 25% decline in P concentration, the most limiting nutrient on this site. Similarly, increasing biomass with declining P concentrations was noted for pigeonpea [ (L). Millsp.] in response to soil moisture availability under intercropping. Although vector analysis depicted nutrient responses, the current vector model does not consider non-nutrient resource effects on growth, such as ameliorated light and soil moisture, which were particularly active in these systems. We revisit and develop vector analysis into a framework for diagnosing nutrient and non-nutrient interactions in agroforestry systems. Such a diagnostic technique advances management decision-making by increasing nutrient precision and reducing environmental issues associated with agrarian-derived soil contamination. American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.

Prediction of Banking Systemic Risk Based on Support Vector Machine

Directory of Open Access Journals (Sweden)

Shouwei Li

2013-01-01

Full Text Available Banking systemic risk is a complex nonlinear phenomenon and has shed light on the importance of safeguarding financial stability by recent financial crisis. According to the complex nonlinear characteristics of banking systemic risk, in this paper we apply support vector machine (SVM to the prediction of banking systemic risk in an attempt to suggest a new model with better explanatory power and stability. We conduct a case study of an SVM-based prediction model for Chinese banking systemic risk and find the experiment results showing that support vector machine is an efficient method in such case.

Efficient modeling of vector hysteresis using fuzzy inference systems

International Nuclear Information System (INIS)

Adly, A.A.; Abd-El-Hafiz, S.K.

2008-01-01

Vector hysteresis models have always been regarded as important tools to determine which multi-dimensional magnetic field-media interactions may be predicted. In the past, considerable efforts have been focused on mathematical modeling methodologies of vector hysteresis. This paper presents an efficient approach based upon fuzzy inference systems for modeling vector hysteresis. Computational efficiency of the proposed approach stems from the fact that the basic non-local memory Preisach-type hysteresis model is approximated by a local memory model. The proposed computational low-cost methodology can be easily integrated in field calculation packages involving massive multi-dimensional discretizations. Details of the modeling methodology and its experimental testing are presented

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer.

Science.gov (United States)

Morille, Marie; Passirani, Catherine; Vonarbourg, Arnaud; Clavreul, Anne; Benoit, Jean-Pierre

2008-01-01

Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its potential role in the treatment of acquired diseases such as cancer is now widely recognized. The understanding of the molecular mechanisms involved in cancer and the development of nucleic acid delivery systems are two concepts that have led to this development. Systemic gene delivery systems are needed for therapeutic application to cells inaccessible by percutaneous injection and for multi-located tumor sites, i.e. metastases. Non-viral vectors based on the use of cationic lipids or polymers appear to have promising potential, given the problems of safety encountered with viral vectors. Using these non-viral vectors, the current challenge is to obtain a similarly effective transfection to viral ones. Based on the advantages and disadvantages of existing vectors and on the hurdles encountered with these carriers, the aim of this review is to describe the "perfect vector" for systemic gene therapy against cancer.

Virus Database and Online Inquiry System Based on Natural Vectors.

Science.gov (United States)

Dong, Rui; Zheng, Hui; Tian, Kun; Yau, Shek-Chung; Mao, Weiguang; Yu, Wenping; Yin, Changchuan; Yu, Chenglong; He, Rong Lucy; Yang, Jie; Yau, Stephen St

2017-01-01

We construct a virus database called VirusDB (http://yaulab.math.tsinghua.edu.cn/VirusDB/) and an online inquiry system to serve people who are interested in viral classification and prediction. The database stores all viral genomes, their corresponding natural vectors, and the classification information of the single/multiple-segmented viral reference sequences downloaded from National Center for Biotechnology Information. The online inquiry system serves the purpose of computing natural vectors and their distances based on submitted genomes, providing an online interface for accessing and using the database for viral classification and prediction, and back-end processes for automatic and manual updating of database content to synchronize with GenBank. Submitted genomes data in FASTA format will be carried out and the prediction results with 5 closest neighbors and their classifications will be returned by email. Considering the one-to-one correspondence between sequence and natural vector, time efficiency, and high accuracy, natural vector is a significant advance compared with alignment methods, which makes VirusDB a useful database in further research.

Energy Systems in the Era of Energy Vectors A Key to Define, Analyze and Design Energy Systems Beyond Fossil Fuels

CERN Document Server

Orecchini, Fabio

2012-01-01

What lies beyond the era of fossil fuels? While most answers focus on different primary energy resources, Energy Systems in the Era of Energy Vectors provides a completely new approach. Instead of providing a traditional consumption analysis of classical primary energy resources such as oil, coal, nuclear power and gas, Energy Systems in the Era of Energy Vectors describes and assesses energy technologies, markets and future strategies, focusing on their capacity to produce, exchange, and use energy vectors. Special attention is given to the renewable energy resources available in different areas of the world and made exploitable by the integration of energy vectors in the global energy system. Clear definitions of energy vectors and energy systems are used as the basis for a complete explanation and assessment of up-to-date, available technologies for energy resources, transport and storage systems, conversion and use. The energy vectors scheme allows the potential realisation of a worldwide sustainable ener...

A versatile system for USER cloning-based assembly of expression vectors for mammalian cell engineering.

Directory of Open Access Journals (Sweden)

Anne Mathilde Lund

Full Text Available A new versatile mammalian vector system for protein production, cell biology analyses, and cell factory engineering was developed. The vector system applies the ligation-free uracil-excision based technique--USER cloning--to rapidly construct mammalian expression vectors of multiple DNA fragments and with maximum flexibility, both for choice of vector backbone and cargo. The vector system includes a set of basic vectors and a toolbox containing a multitude of DNA building blocks including promoters, terminators, selectable marker- and reporter genes, and sequences encoding an internal ribosome entry site, cellular localization signals and epitope- and purification tags. Building blocks in the toolbox can be easily combined as they contain defined and tested Flexible Assembly Sequence Tags, FASTs. USER cloning with FASTs allows rapid swaps of gene, promoter or selection marker in existing plasmids and simple construction of vectors encoding proteins, which are fused to fluorescence-, purification-, localization-, or epitope tags. The mammalian expression vector assembly platform currently allows for the assembly of up to seven fragments in a single cloning step with correct directionality and with a cloning efficiency above 90%. The functionality of basic vectors for FAST assembly was tested and validated by transient expression of fluorescent model proteins in CHO, U-2-OS and HEK293 cell lines. In this test, we included many of the most common vector elements for heterologous gene expression in mammalian cells, in addition the system is fully extendable by other users. The vector system is designed to facilitate high-throughput genome-scale studies of mammalian cells, such as the newly sequenced CHO cell lines, through the ability to rapidly generate high-fidelity assembly of customizable gene expression vectors.

Global Positioning Systems (GPS) Technology to Study Vector-Pathogen-Host Interactions

Science.gov (United States)

2016-12-01

Award Number: W81XWH-11-2-0175 TITLE: Global Positioning Systems (GPS) Technology to Study Vector-Pathogen-Host Interactions PRINCIPAL...Positioning Systems (GPS) Technology to Study Vector-Pathogen-Host Interactions 5b. GRANT NUMBER W81XWH-11-2-0175 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...genetic diversity in the population, in hospitalized children with severe dengue illness and cluster investigation of their neighborhoods, and by using

Availability of thermodynamic system with multiple performance parameters based on vector-universal generating function

International Nuclear Information System (INIS)

Cai Qi; Shang Yanlong; Chen Lisheng; Zhao Yuguang

2013-01-01

Vector-universal generating function was presented to analyze the availability of thermodynamic system with multiple performance parameters. Vector-universal generating function of component's performance was defined, the arithmetic model based on vector-universal generating function was derived for the thermodynamic system, and the calculation method was given for state probability of multi-state component. With the stochastic simulation of the degeneration trend of the multiple factors, the system availability with multiple performance parameters was obtained under composite factors. It is shown by an example that the results of the availability obtained by the binary availability analysis method are somewhat conservative, and the results considering parameter failure based on vector-universal generating function reflect the operation characteristics of the thermodynamic system better. (authors)

Ces-VP: consultation expert system for vector programming of nuclear codes

International Nuclear Information System (INIS)

Fujisaki, Masahide; Makino, Mitsuhiro; Ishiguro, Misako

1988-08-01

Ces-VP is a prototype rule-based expert system for consulting the vector programming, based on the knowledge of vectorization of nuclear codes at JAERI during these 10 years. Experts in vectorization can restructure nuclear codes with high performance on vector processors, since they have know-how for choosing the best technique among a lot of techniques that were acquired from the experience of vectorization in the past. Frequency in trial and error will be reduced if a beginner can easily use the know-how of experts. In this report, at first the contents of Ces-VP and its intention are shown. Then, the method for acquiring the know-how of vectorization and the method for making rules from the know-how are described. The outline of Ces-VP implemented on Fujitsu expert tool ESHELL is described. Finally, the availability of Ces-VP is evaluated from the data gathered from practical use and its present problems are discussed. (author)

Vectorization, parallelization and porting of nuclear codes. Vectorization and parallelization. Progress report fiscal 1999

Energy Technology Data Exchange (ETDEWEB)

Adachi, Masaaki; Ogasawara, Shinobu; Kume, Etsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Ishizuki, Shigeru; Nemoto, Toshiyuki; Kawasaki, Nobuo; Kawai, Wataru [Fujitsu Ltd., Tokyo (Japan); Yatake, Yo-ichi [Hitachi Ltd., Tokyo (Japan)

2001-02-01

Several computer codes in the nuclear field have been vectorized, parallelized and trans-ported on the FUJITSU VPP500 system, the AP3000 system, the SX-4 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 18 codes in fiscal 1999. These results are reported in 3 parts, i.e., the vectorization and the parallelization part on vector processors, the parallelization part on scalar processors and the porting part. In this report, we describe the vectorization and parallelization on vector processors. In this vectorization and parallelization on vector processors part, the vectorization of Relativistic Molecular Orbital Calculation code RSCAT, a microscopic transport code for high energy nuclear collisions code JAM, three-dimensional non-steady thermal-fluid analysis code STREAM, Relativistic Density Functional Theory code RDFT and High Speed Three-Dimensional Nodal Diffusion code MOSRA-Light on the VPP500 system and the SX-4 system are described. (author)

Testing resonating vector strength: Auditory system, electric fish, and noise

Science.gov (United States)

Leo van Hemmen, J.; Longtin, André; Vollmayr, Andreas N.

2011-12-01

Quite often a response to some input with a specific frequency ν○ can be described through a sequence of discrete events. Here, we study the synchrony vector, whose length stands for the vector strength, and in doing so focus on neuronal response in terms of spike times. The latter are supposed to be given by experiment. Instead of singling out the stimulus frequency ν○ we study the synchrony vector as a function of the real frequency variable ν. Its length turns out to be a resonating vector strength in that it shows clear maxima in the neighborhood of ν○ and multiples thereof, hence, allowing an easy way of determining response frequencies. We study this "resonating" vector strength for two concrete but rather different cases, viz., a specific midbrain neuron in the auditory system of cat and a primary detector neuron belonging to the electric sense of the wave-type electric fish Apteronotus leptorhynchus. We show that the resonating vector strength always performs a clear resonance correlated with the phase locking that it quantifies. We analyze the influence of noise and demonstrate how well the resonance associated with maximal vector strength indicates the dominant stimulus frequency. Furthermore, we exhibit how one can obtain a specific phase associated with, for instance, a delay in auditory analysis.

Kochen-Specker vectors

International Nuclear Information System (INIS)

Pavicic, Mladen; Merlet, Jean-Pierre; McKay, Brendan; Megill, Norman D

2005-01-01

We give a constructive and exhaustive definition of Kochen-Specker (KS) vectors in a Hilbert space of any dimension as well as of all the remaining vectors of the space. KS vectors are elements of any set of orthonormal states, i.e., vectors in an n-dimensional Hilbert space, H n , n≥3, to which it is impossible to assign 1s and 0s in such a way that no two mutually orthogonal vectors from the set are both assigned 1 and that not all mutually orthogonal vectors are assigned 0. Our constructive definition of such KS vectors is based on algorithms that generate MMP diagrams corresponding to blocks of orthogonal vectors in R n , on algorithms that single out those diagrams on which algebraic (0)-(1) states cannot be defined, and on algorithms that solve nonlinear equations describing the orthogonalities of the vectors by means of statistically polynomially complex interval analysis and self-teaching programs. The algorithms are limited neither by the number of dimensions nor by the number of vectors. To demonstrate the power of the algorithms, all four-dimensional KS vector systems containing up to 24 vectors were generated and described, all three-dimensional vector systems containing up to 30 vectors were scanned, and several general properties of KS vectors were found

Vector disparity sensor with vergence control for active vision systems.

Science.gov (United States)

Barranco, Francisco; Diaz, Javier; Gibaldi, Agostino; Sabatini, Silvio P; Ros, Eduardo

2012-01-01

This paper presents an architecture for computing vector disparity for active vision systems as used on robotics applications. The control of the vergence angle of a binocular system allows us to efficiently explore dynamic environments, but requires a generalization of the disparity computation with respect to a static camera setup, where the disparity is strictly 1-D after the image rectification. The interaction between vision and motor control allows us to develop an active sensor that achieves high accuracy of the disparity computation around the fixation point, and fast reaction time for the vergence control. In this contribution, we address the development of a real-time architecture for vector disparity computation using an FPGA device. We implement the disparity unit and the control module for vergence, version, and tilt to determine the fixation point. In addition, two on-chip different alternatives for the vector disparity engines are discussed based on the luminance (gradient-based) and phase information of the binocular images. The multiscale versions of these engines are able to estimate the vector disparity up to 32 fps on VGA resolution images with very good accuracy as shown using benchmark sequences with known ground-truth. The performances in terms of frame-rate, resource utilization, and accuracy of the presented approaches are discussed. On the basis of these results, our study indicates that the gradient-based approach leads to the best trade-off choice for the integration with the active vision system.

Efficient VEGF targeting delivery of DOX using Bevacizumab conjugated SiO2@LDH for anti-neuroblastoma therapy.

Science.gov (United States)

Zhu, Rongrong; Wang, Zhaoqi; Liang, Peng; He, Xiaolie; Zhuang, Xizhen; Huang, Ruiqi; Wang, Mei; Wang, Qigang; Qian, Yechang; Wang, Shilong

2017-11-01

Bevacizumab (Bev) to form a new tumor vasculature targeting nanocarrier SiO 2 @LDH-Bev as vector of DOX, which was not reported before. The results indicated that SiO 2 @LDH-Bev could improve the VEGF targeting ability, anti-neuroblastoma and anti-angiogenesis efficiency of DOX. At the same time, SiO 2 @LDH-Bev-DOX could erase the cardiac toxicity and hepatic injury coming from DOX. Tube formation showed SiO 2 @LDH-Bev-DOX had the strongest effect on inhibiting angiogenesis among all the four formulations. SiO 2 @LDH-Bev-DOX could downregulate expression of p-VEGFR and inhibit activation of the Raf/MEK/ERK, p38MAPK, PI3K/Akt and FAK signaling pathways to achieve the goal of anti-angiogenesis. This work provides a novel system for the safe and efficient use of Bev and DOX on Neuroblastoma and explores the mechanism of the function of nano carrier in cancer therapy both in vitro and in vivo. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Experimental analysis of Hybridised Energy Storage Systems for automotive applications

Science.gov (United States)

Sarwar, Wasim; Engstrom, Timothy; Marinescu, Monica; Green, Nick; Taylor, Nigel; Offer, Gregory J.

2016-08-01

The requirements of the Energy Storage System (ESS) for an electrified vehicle portfolio consisting of a range of vehicles from micro Hybrid Electric Vehicle (mHEV) to a Battery Electric Vehicle (BEV) vary considerably. To reduce development cost of an electrified powertrain portfolio, a modular system would ideally be scaled across each vehicle; however, the conflicting requirements of a mHEV and BEV prevent this. This study investigates whether it is possible to combine supercapacitors suitable for an mHEV with high-energy batteries suitable for use in a BEV to create a Hybridised Energy Storage System (HESS) suitable for use in a HEV. A passive HESS is found to be capable of meeting the electrical demands of a HEV drive cycle; the operating principles of HESSs are discussed and factors limiting system performance are explored. The performance of the HESS is found to be significantly less temperature dependent than battery-only systems, however the heat generated suggests a requirement for thermal management. As the HESS degrades (at a similar rate to a specialised high-power-battery), battery resistance rises faster than supercapacitor resistance; as a result, the supercapacitor provides a greater current contribution, therefore the energy throughput, temperature rise and degradation of the batteries is reduced.

Vehicle energy consumption - A contribution to the Coherent Energy and Environmental System Analysis (CEESA) project

Energy Technology Data Exchange (ETDEWEB)

Schaltz, E.

2011-01-15

In this report simulation models of a Battery Electric Vehicle (BEV) and a Fuel Cell Hybrid Electric Vehicle (FCHEV) have been developed. The models have two features: they both design the vehicles and calculates the energy consumption, efficiency, mass, volume, and cost due to a given drive cycle. The vehicles are designed to fulfill a drive cycle which consist of city, road, and motorway driving, as it is desired that the vehicles should have the same performance as traditional internal combustion engine (ICE) vehicles. For this reason its also chosen to use a midsize car, i.e. a Toyota Avensis, as reference vehicle. The simulation models consist of several sub-models, which have been modeled by use of data sheets. The models have therefore not been verified be experimental results, which is strongly recommenced for future work. The energy consumption per km and efficiency are significant better for the BEV than for the FCHEV. The average energy consumption per km is 304.1 Wh/km and 635.7 Wh/km for the BEV and FCHEV, respectively. The average tank-to-wheel efficiency of the BEV and FCHEV are 54.0% and 23.4%, respectively. For the total car mass and cost and volume of the power system, the results are two-sided. For short distance the BEV is lighter, has smaller volume of the power system, and are cheaper than the FCHEV. However, when the traveling distance increases the difference becomes smaller, and at long distances the FCHEV are the lightest, smallest, and cheapest. (Author)

Vector Development for the Expression of Foreign Proteins in the Vaccine Strain Brucella abortus S19

Science.gov (United States)

Comerci, Diego J.; Pollevick, Guido D.; Vigliocco, Ana M.; Frasch, Alberto C. C.; Ugalde, Rodolfo A.

1998-01-01

A vector for the expression of foreign antigens in the vaccine strain Brucella abortus S19 was developed by using a DNA fragment containing the regulatory sequences and the signal peptide of the Brucella bcsp31 gene. This fragment was cloned in broad-host-range plasmid pBBR4MCS, resulting in plasmid pBEV. As a reporter protein, a repetitive antigen of Trypanosoma cruzi was used. The recombinant fusion protein is stably expressed and secreted into the Brucella periplasmic space, inducing a good antibody response against the T. cruzi antigen. The expression of the repetitive antigen in Brucella neither altered its growth pattern nor generated a toxic or lethal effect during experimental infection. The application of this strategy for the generation of live recombinant vaccines and the tagging of B. abortus S19 vaccine is discussed. This is the first time that a recombinant protein has been expressed in the periplasm of brucellae. PMID:9673273

Bevægelser i og på tværs af ekstreme grupper og bande- og rockermiljøet

DEFF Research Database (Denmark)

Christensen, Tina Wilchen; Mørck, Line Lerche

/ekstreme grupper og netværk. Denne rapport giver således et billede af de komplekse bevægelsesmønstre i og på tværs af kriminelle netværk, bander, rockere og ekstreme grupper. Den giver en nuanceret forståelse af de veje ind, processer og perspektiver, der er nødvendige at begribe, når man skal udvikle og arbejde...... udsagn og handling. Når ”Cross-over” bygger videre på disse etablerede antagelser risikerer vi, at antagelserne med tiden etableres som forklaringer. Den etablerede ”Cross-over” kategori kan derved utilsigtet medvirke til, at vi overser de komplekse dynamikker, der er på spil i og på tværs af kriminelle...

Sequential Bethe vectors and the quantum Ernst system

International Nuclear Information System (INIS)

Niedermaier, M.; Samtleben, H.

2000-01-01

We give a brief review on the use of Bethe Ansatz techniques to construct solutions of recursive functional equations which emerged in a bootstrap approach to the quantum Ernst system. The construction involves two particular limits of a rational Bethe Ansatz system with complex inhomogeneities. First, we pinch two insertions to the critical value. This links Bethe systems with different number of insertions and leads to the concept of sequential Bethe vectors. Second, we study the semiclassical limit of the system in which the scale parameter of the insertions tends to infinity. (author)

MODELING OF DYNAMIC SYSTEMS WITH MODULATION BY MEANS OF KRONECKER VECTOR-MATRIX REPRESENTATION

Directory of Open Access Journals (Sweden)

A. S. Vasilyev

2015-09-01

Full Text Available The paper deals with modeling of dynamic systems with modulation by the possibilities of state-space method. This method, being the basis of modern control theory, is based on the possibilities of vector-matrix formalism of linear algebra and helps to solve various problems of technical control of continuous and discrete nature invariant with respect to the dimension of their “input-output” objects. Unfortunately, it turned its back on the wide group of control systems, which hardware environment modulates signals. The marked system deficiency is partially offset by this paper, which proposes Kronecker vector-matrix representations for purposes of system representation of processes with signal modulation. The main result is vector-matrix representation of processes with modulation with no formal difference from continuous systems. It has been found that abilities of these representations could be effectively used in research of systems with modulation. Obtained model representations of processes with modulation are best adapted to the state-space method. These approaches for counting eigenvalues of Kronecker matrix summaries, that are matrix basis of model representations of processes described by Kronecker vector products, give the possibility to use modal direction in research of dynamics for systems with modulation. It is shown that the use of controllability for eigenvalues of general matrixes applied to Kronecker structures enabled to divide successfully eigenvalue spectrum into directed and not directed components. Obtained findings including design problems for models of dynamic processes with modulation based on the features of Kronecker vector and matrix structures, invariant with respect to the dimension of input-output relations, are applicable in the development of alternate current servo drives.

Strategic vectors of transformational shifts in the national tourism system of Ukraine

Directory of Open Access Journals (Sweden)

Alla OKHRIMENKO

2017-10-01

Full Text Available The article determines transformational factors, which influence a national tourism system (NTS of Ukraine and proposes strategical vectors of its development. Research of the NTS as an economic system is a pre-condition for formation of strategic vectors of development. Transformational driving forces principally change scales, components, and proportions between external and internal factors of development of the NTS. Correspondingly, the mentioned processes objectively encourage modernization of the national tourism system and application of innovative managerial methods. The following Strategical vectors of transformational shifts in the NTS were grounded: 1 Safety of tourists and investors; 2 The normative and legislative framework of the NTS development; 3 Development of infrastructure of the NTS component; 4 Human resources development; 5 A marketing policy of the NTS promotion; 6 Ecological and cultural policies. Their implementation will improve efficiency and competitiveness of the NTS and the national economy.

Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system.

Science.gov (United States)

Han, Seung-Soo; Lee, Jinjoo; Jung, Yideul; Kang, Myeong-Ho; Hong, Jung-Hyub; Cha, Min-Suk; Park, Yu-Jin; Lee, Ezra; Yoon, Cheol-Hee; Bae, Yong-Soo

2015-09-11

We developed a CTL vaccine vector by modification of the RPS-Vax system, a mucosal vaccine vector derived from a poliovirus Sabin 1 strain, and generated an oral CTL vaccine against HIV-1. A DNA fragment encoding a cytoplasmic transduction peptide (CTP) was integrated into the RPS-Vax system to generate RPS-CTP, a CTL vaccine vector. An HIV-1 p24 cDNA fragment was introduced into the RPS-CTP vector system and a recombinant poliovirus (rec-PV) named vRPS-CTP/p24 was produced. vRPS-CTP/p24 was genetically stable and efficiently induced Th1 immunity and p24-specific CTLs in immunized poliovirus receptor-transgenic (PVR-Tg) mice. In challenge experiments, PVR-Tg mice that were pre-immunized orally with vRPS-CTP/p24 were resistant to challenge with a lethal dose of p24-expressing recombinant vaccinia virus (rMVA-p24). These results suggested that the RPS-CTP vector system had potential for developing oral CTL vaccines against infectious diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

A static investigation of the thrust vectoring system of the F/A-18 high-alpha research vehicle

Science.gov (United States)

Mason, Mary L.; Capone, Francis J.; Asbury, Scott C.

1992-01-01

A static (wind-off) test was conducted in the static test facility of the Langley 16-foot Transonic Tunnel to evaluate the vectoring capability and isolated nozzle performance of the proposed thrust vectoring system of the F/A-18 high alpha research vehicle (HARV). The thrust vectoring system consisted of three asymmetrically spaced vanes installed externally on a single test nozzle. Two nozzle configurations were tested: A maximum afterburner-power nozzle and a military-power nozzle. Vane size and vane actuation geometry were investigated, and an extensive matrix of vane deflection angles was tested. The nozzle pressure ratios ranged from two to six. The results indicate that the three vane system can successfully generate multiaxis (pitch and yaw) thrust vectoring. However, large resultant vector angles incurred large thrust losses. Resultant vector angles were always lower than the vane deflection angles. The maximum thrust vectoring angles achieved for the military-power nozzle were larger than the angles achieved for the maximum afterburner-power nozzle.

Novel scanning procedure enabling the vectorization of entire rhizotron-grown root systems

Directory of Open Access Journals (Sweden)

Lobet Guillaume

2013-01-01

Full Text Available Abstract This paper presents an original spit-and-combine imaging procedure that enables the complete vectorization of complex root systems grown in rhizotrons. The general principle of the method is to (1 separate the root system into a small number of large pieces to reduce root overlap, (2 scan these pieces one by one, (3 analyze separate images with a root tracing software and (4 combine all tracings into a single vectorized root system. This method generates a rich dataset containing morphological, topological and geometrical information of entire root systems grown in rhizotrons. The utility of the method is illustrated with a detailed architectural analysis of a 20-day old maize root system, coupled with a spatial analysis of water uptake patterns.

Novel scanning procedure enabling the vectorization of entire rhizotron-grown root systems.

Science.gov (United States)

Lobet, Guillaume; Draye, Xavier

2013-01-04

: This paper presents an original spit-and-combine imaging procedure that enables the complete vectorization of complex root systems grown in rhizotrons. The general principle of the method is to (1) separate the root system into a small number of large pieces to reduce root overlap, (2) scan these pieces one by one, (3) analyze separate images with a root tracing software and (4) combine all tracings into a single vectorized root system. This method generates a rich dataset containing morphological, topological and geometrical information of entire root systems grown in rhizotrons. The utility of the method is illustrated with a detailed architectural analysis of a 20-day old maize root system, coupled with a spatial analysis of water uptake patterns.

Complex Polynomial Vector Fields

DEFF Research Database (Denmark)

The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...... or meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...

Baculovirus expression vector system: An efficient tool for the ...

African Journals Online (AJOL)

Baculovirus expression vector system is considered one of the most successful and widely acceptable means for the production of recombinant proteins in extremely large quantities. Proper posttranslational modifications of the expressed proteins in insect cells, the usual host of baculoviruses, get them soluble, correctly ...

Vectorization, parallelization and porting of nuclear codes (vectorization and parallelization). Progress report fiscal 1998

International Nuclear Information System (INIS)

Ishizuki, Shigeru; Kawai, Wataru; Nemoto, Toshiyuki; Ogasawara, Shinobu; Kume, Etsuo; Adachi, Masaaki; Kawasaki, Nobuo; Yatake, Yo-ichi

2000-03-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system, the AP3000 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 12 codes in fiscal 1998. These results are reported in 3 parts, i.e., the vectorization and parallelization on vector processors part, the parallelization on scalar processors part and the porting part. In this report, we describe the vectorization and parallelization on vector processors. In this vectorization and parallelization on vector processors part, the vectorization of General Tokamak Circuit Simulation Program code GTCSP, the vectorization and parallelization of Molecular Dynamics NTV (n-particle, Temperature and Velocity) Simulation code MSP2, Eddy Current Analysis code EDDYCAL, Thermal Analysis Code for Test of Passive Cooling System by HENDEL T2 code THANPACST2 and MHD Equilibrium code SELENEJ on the VPP500 are described. In the parallelization on scalar processors part, the parallelization of Monte Carlo N-Particle Transport code MCNP4B2, Plasma Hydrodynamics code using Cubic Interpolated Propagation Method PHCIP and Vectorized Monte Carlo code (continuous energy model / multi-group model) MVP/GMVP on the Paragon are described. In the porting part, the porting of Monte Carlo N-Particle Transport code MCNP4B2 and Reactor Safety Analysis code RELAP5 on the AP3000 are described. (author)

Axial-vector gluons and the fine structure of heavy quark--antiquark systems

International Nuclear Information System (INIS)

Feinberg, G.; Lynn, B.; Sucher, J.

1979-01-01

We point out that two models of the origin of spin-dependent forces in heavy quark systems make very different predictions about the relative size of these forces in c-barc and b-barb. The model in which these forces are relativistic corrections to vector or scalar gluon exchange predicts smaller spin-dependent effects in b-barb than in c-barc while a model in which these forces are due to exchange of axial-vector gluons predicts a similar size for spin-dependent splittings in the two systems

A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering

DEFF Research Database (Denmark)

Lund, Anne Mathilde; Kildegaard, Helene Faustrup; Petersen, Maja Borup Kjær

2014-01-01

, in addition the system is fully extendable by other users. The vector system is designed to facilitate high-throughput genome-scale studies of mammalian cells, such as the newly sequenced CHO cell lines, through the ability to rapidly generate high-fidelity assembly of customizable gene expression vectors....

A simple vector system to improve performance and utilisation of recombinant antibodies

Directory of Open Access Journals (Sweden)

Vincent Karen J

2006-12-01

Full Text Available Abstract Background Isolation of recombinant antibody fragments from antibody libraries is well established using technologies such as phage display. Phage display vectors are ideal for efficient display of antibody fragments on the surface of bacteriophage particles. However, they are often inefficient for expression of soluble antibody fragments, and sub-cloning of selected antibody populations into dedicated soluble antibody fragment expression vectors can enhance expression. Results We have developed a simple vector system for expression, dimerisation and detection of recombinant antibody fragments in the form of single chain Fvs (scFvs. Expression is driven by the T7 RNA polymerase promoter in conjunction with the inducible lysogen strain BL21 (DE3. The system is compatible with a simple auto-induction culture system for scFv production. As an alternative to periplasmic expression, expression directly in the cytoplasm of a mutant strain with a more oxidising cytoplasmic environment (Origami 2™ (DE3 was investigated and found to be inferior to periplasmic expression in BL21 (DE3 cells. The effect on yield and binding activity of fusing scFvs to the N terminus of maltose binding protein (a solubility enhancing partner, bacterial alkaline phosphatase (a naturally dimeric enzymatic reporter molecule, or the addition of a free C-terminal cysteine was determined. Fusion of scFvs to the N-terminus of maltose binding protein increased scFv yield but binding activity of the scFv was compromised. In contrast, fusion to the N-terminus of bacterial alkaline phosphatase led to an improved performance. Alkaline phosphatase provides a convenient tag allowing direct enzymatic detection of scFv fusions within crude extracts without the need for secondary reagents. Alkaline phosphatase also drives dimerisation of the scFv leading to an improvement in performance compared to monovalent constructs. This is illustrated by ELISA, western blot and

Complex Polynomial Vector Fields

DEFF Research Database (Denmark)

Dias, Kealey

vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields.......The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions...

Command vector memory systems: high performance at low cost

OpenAIRE

Corbal San Adrián, Jesús; Espasa Sans, Roger; Valero Cortés, Mateo

1998-01-01

The focus of this paper is on designing both a low cost and high performance, high bandwidth vector memory system that takes advantage of modern commodity SDRAM memory chips. To successfully extract the full bandwidth from SDRAM parts, we propose a new memory system organization based on sending commands to the memory system as opposed to sending individual addresses. A command specifies, in a few bytes, a request for multiple independent memory words. A command is similar to a burst found in...

Modelling and Simulation of SVPWM Based Vector Controlled HVDC Light Systems

Directory of Open Access Journals (Sweden)

Ajay Kumar MOODADLA

2012-11-01

Full Text Available Recent upgrades in power electronics technology have lead to the improvements of insulated gate bipolar transistor (IGBT based Voltage source converter High voltage direct current (VSC HVDC transmission systems. These are also commercially known as HVDC Light systems, which are popular in renewable, micro grid, and electric power systems. Out of different pulse width modulation (PWM schemes, Space vector PWM (SVPWM control scheme finds growing importance in power system applications because of its better dc bus utilization. In this paper, modelling of the converter is described, and SVPWM scheme is utilized to control the HVDC Light system in order to achieve better DC bus utilization, harmonic reduction, and for reduced power fluctuations. The simulations are carried out in the MATLAB/SIMULINK environment and the results are provided for steady state and dynamic conditions. Finally, the performance of SVPWM based vector controlled HVDC Light transmission system is compared with sinusoidal pulse width modulation (SPWM based HVDC Light system in terms of output voltage and total harmonic distortion (THD.

Hyperbolic-symmetry vector fields.

Science.gov (United States)

Gao, Xu-Zhen; Pan, Yue; Cai, Meng-Qiang; Li, Yongnan; Tu, Chenghou; Wang, Hui-Tian

2015-12-14

We present and construct a new kind of orthogonal coordinate system, hyperbolic coordinate system. We present and design a new kind of local linearly polarized vector fields, which is defined as the hyperbolic-symmetry vector fields because the points with the same polarization form a series of hyperbolae. We experimentally demonstrate the generation of such a kind of hyperbolic-symmetry vector optical fields. In particular, we also study the modified hyperbolic-symmetry vector optical fields with the twofold and fourfold symmetric states of polarization when introducing the mirror symmetry. The tight focusing behaviors of these vector fields are also investigated. In addition, we also fabricate micro-structures on the K9 glass surfaces by several tightly focused (modified) hyperbolic-symmetry vector fields patterns, which demonstrate that the simulated tightly focused fields are in good agreement with the fabricated micro-structures.

A formula for the Bloch vector of some Lindblad quantum systems

International Nuclear Information System (INIS)

Salgado, D.; Sanchez-Gomez, J.L.

2004-01-01

Using the Bloch representation of an N-dimensional quantum system and immediate results from quantum stochastic calculus, we establish a closed formula for the Bloch vector, hence also for the density operator, of a quantum system following a Lindblad evolution with selfadjoint Lindblad operators

Symbolic computer vector analysis

Science.gov (United States)

Stoutemyer, D. R.

1977-01-01

A MACSYMA program is described which performs symbolic vector algebra and vector calculus. The program can combine and simplify symbolic expressions including dot products and cross products, together with the gradient, divergence, curl, and Laplacian operators. The distribution of these operators over sums or products is under user control, as are various other expansions, including expansion into components in any specific orthogonal coordinate system. There is also a capability for deriving the scalar or vector potential of a vector field. Examples include derivation of the partial differential equations describing fluid flow and magnetohydrodynamics, for 12 different classic orthogonal curvilinear coordinate systems.

Vectorization of KENO IV code and an estimate of vector-parallel processing

International Nuclear Information System (INIS)

Asai, Kiyoshi; Higuchi, Kenji; Katakura, Jun-ichi; Kurita, Yutaka.

1986-10-01

The multi-group criticality safety code KENO IV has been vectorized and tested on FACOM VP-100 vector processor. At first the vectorized KENO IV on a scalar processor became slower than the original one by a factor of 1.4 because of the overhead introduced by the vectorization. Making modifications of algorithms and techniques for vectorization, the vectorized version has become faster than the original one by a factor of 1.4 and 3.0 on the vector processor for sample problems of complex and simple geometries, respectively. For further speedup of the code, some improvements on compiler and hardware, especially on addition of Monte Carlo pipelines to the vector processor, are discussed. Finally a pipelined parallel processor system is proposed and its performance is estimated. (author)

Multiscale asymmetric orthogonal wavelet kernel for linear programming support vector learning and nonlinear dynamic systems identification.

Science.gov (United States)

Lu, Zhao; Sun, Jing; Butts, Kenneth

2014-05-01

Support vector regression for approximating nonlinear dynamic systems is more delicate than the approximation of indicator functions in support vector classification, particularly for systems that involve multitudes of time scales in their sampled data. The kernel used for support vector learning determines the class of functions from which a support vector machine can draw its solution, and the choice of kernel significantly influences the performance of a support vector machine. In this paper, to bridge the gap between wavelet multiresolution analysis and kernel learning, the closed-form orthogonal wavelet is exploited to construct new multiscale asymmetric orthogonal wavelet kernels for linear programming support vector learning. The closed-form multiscale orthogonal wavelet kernel provides a systematic framework to implement multiscale kernel learning via dyadic dilations and also enables us to represent complex nonlinear dynamics effectively. To demonstrate the superiority of the proposed multiscale wavelet kernel in identifying complex nonlinear dynamic systems, two case studies are presented that aim at building parallel models on benchmark datasets. The development of parallel models that address the long-term/mid-term prediction issue is more intricate and challenging than the identification of series-parallel models where only one-step ahead prediction is required. Simulation results illustrate the effectiveness of the proposed multiscale kernel learning.

Vectorization of phase space Monte Carlo code in FACOM vector processor VP-200

International Nuclear Information System (INIS)

Miura, Kenichi

1986-01-01

This paper describes the vectorization techniques for Monte Carlo codes in Fujitsu's Vector Processor System. The phase space Monte Carlo code FOWL is selected as a benchmark, and scalar and vector performances are compared. The vectorized kernel Monte Carlo routine which contains heavily nested IF tests runs up to 7.9 times faster in vector mode than in scalar mode. The overall performance improvement of the vectorized FOWL code over the original scalar code reaches 3.3. The results of this study strongly indicate that supercomputer can be a powerful tool for Monte Carlo simulations in high energy physics. (Auth.)

Vector grammars and PN machines

Institute of Scientific and Technical Information of China (English)

蒋昌俊

1996-01-01

The concept of vector grammars under the string semantic is introduced.The dass of vector grammars is given,which is similar to the dass of Chomsky grammars.The regular vector grammar is divided further.The strong and weak relation between the vector grammar and scalar grammar is discussed,so the spectrum system graph of scalar and vector grammars is made.The equivalent relation between the regular vector grammar and Petri nets (also called PN machine) is pointed.The hybrid PN machine is introduced,and its language is proved equivalent to the language of the context-free vector grammar.So the perfect relation structure between vector grammars and PN machines is formed.

A Novel Rotor and Stator Magnetic Fields Direct-Orthogonalized Vector Control Scheme for the PMSM Servo System

Directory of Open Access Journals (Sweden)

Shi-Xiong Zhang

2014-02-01

Full Text Available Permanent Magnet Synchronous motor (PMSM has received widespread acceptance in recent years. In this paper, a new rotor and stator Magnetic Fields Direct-Orthogonalized Vector Control (MFDOVC scheme is proposed for PMSM servo system. This method simplified the complex calculation of traditional vector control, a part of the system resource is economized. At the same time, through the simulation illustration validation, the performance of PMSM servo system with the proposed MFDOVC scheme can achieve the same with the complex traditional vector control method, but much simpler calculation is implemented using the proposed method.

Energy efficiency analysis: biomass-to-wheel efficiency related with biofuels production, fuel distribution, and powertrain systems.

Directory of Open Access Journals (Sweden)

Wei-Dong Huang

Full Text Available BACKGROUND: Energy efficiency analysis for different biomass-utilization scenarios would help make more informed decisions for developing future biomass-based transportation systems. Diverse biofuels produced from biomass include cellulosic ethanol, butanol, fatty acid ethyl esters, methane, hydrogen, methanol, dimethyether, Fischer-Tropsch diesel, and bioelectricity; the respective powertrain systems include internal combustion engine (ICE vehicles, hybrid electric vehicles based on gasoline or diesel ICEs, hydrogen fuel cell vehicles, sugar fuel cell vehicles (SFCV, and battery electric vehicles (BEV. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a simple, straightforward, and transparent biomass-to-wheel (BTW analysis including three separate conversion elements--biomass-to-fuel conversion, fuel transport and distribution, and respective powertrain systems. BTW efficiency is a ratio of the kinetic energy of an automobile's wheels to the chemical energy of delivered biomass just before entering biorefineries. Up to 13 scenarios were analyzed and compared to a base line case--corn ethanol/ICE. This analysis suggests that BEV, whose electricity is generated from stationary fuel cells, and SFCV, based on a hydrogen fuel cell vehicle with an on-board sugar-to-hydrogen bioreformer, would have the highest BTW efficiencies, nearly four times that of ethanol-ICE. SIGNIFICANCE: In the long term, a small fraction of the annual US biomass (e.g., 7.1%, or 700 million tons of biomass would be sufficient to meet 100% of light-duty passenger vehicle fuel needs (i.e., 150 billion gallons of gasoline/ethanol per year, through up to four-fold enhanced BTW efficiencies by using SFCV or BEV. SFCV would have several advantages over BEV: much higher energy storage densities, faster refilling rates, better safety, and less environmental burdens.

Energy Efficiency Analysis: Biomass-to-Wheel Efficiency Related with Biofuels Production, Fuel Distribution, and Powertrain Systems

Science.gov (United States)

Huang, Wei-Dong; Zhang, Y-H Percival

2011-01-01

Background Energy efficiency analysis for different biomass-utilization scenarios would help make more informed decisions for developing future biomass-based transportation systems. Diverse biofuels produced from biomass include cellulosic ethanol, butanol, fatty acid ethyl esters, methane, hydrogen, methanol, dimethyether, Fischer-Tropsch diesel, and bioelectricity; the respective powertrain systems include internal combustion engine (ICE) vehicles, hybrid electric vehicles based on gasoline or diesel ICEs, hydrogen fuel cell vehicles, sugar fuel cell vehicles (SFCV), and battery electric vehicles (BEV). Methodology/Principal Findings We conducted a simple, straightforward, and transparent biomass-to-wheel (BTW) analysis including three separate conversion elements -- biomass-to-fuel conversion, fuel transport and distribution, and respective powertrain systems. BTW efficiency is a ratio of the kinetic energy of an automobile's wheels to the chemical energy of delivered biomass just before entering biorefineries. Up to 13 scenarios were analyzed and compared to a base line case – corn ethanol/ICE. This analysis suggests that BEV, whose electricity is generated from stationary fuel cells, and SFCV, based on a hydrogen fuel cell vehicle with an on-board sugar-to-hydrogen bioreformer, would have the highest BTW efficiencies, nearly four times that of ethanol-ICE. Significance In the long term, a small fraction of the annual US biomass (e.g., 7.1%, or 700 million tons of biomass) would be sufficient to meet 100% of light-duty passenger vehicle fuel needs (i.e., 150 billion gallons of gasoline/ethanol per year), through up to four-fold enhanced BTW efficiencies by using SFCV or BEV. SFCV would have several advantages over BEV: much higher energy storage densities, faster refilling rates, better safety, and less environmental burdens. PMID:21765941

Energy efficiency analysis: biomass-to-wheel efficiency related with biofuels production, fuel distribution, and powertrain systems.

Science.gov (United States)

Huang, Wei-Dong; Zhang, Y-H Percival

2011-01-01

Energy efficiency analysis for different biomass-utilization scenarios would help make more informed decisions for developing future biomass-based transportation systems. Diverse biofuels produced from biomass include cellulosic ethanol, butanol, fatty acid ethyl esters, methane, hydrogen, methanol, dimethyether, Fischer-Tropsch diesel, and bioelectricity; the respective powertrain systems include internal combustion engine (ICE) vehicles, hybrid electric vehicles based on gasoline or diesel ICEs, hydrogen fuel cell vehicles, sugar fuel cell vehicles (SFCV), and battery electric vehicles (BEV). We conducted a simple, straightforward, and transparent biomass-to-wheel (BTW) analysis including three separate conversion elements--biomass-to-fuel conversion, fuel transport and distribution, and respective powertrain systems. BTW efficiency is a ratio of the kinetic energy of an automobile's wheels to the chemical energy of delivered biomass just before entering biorefineries. Up to 13 scenarios were analyzed and compared to a base line case--corn ethanol/ICE. This analysis suggests that BEV, whose electricity is generated from stationary fuel cells, and SFCV, based on a hydrogen fuel cell vehicle with an on-board sugar-to-hydrogen bioreformer, would have the highest BTW efficiencies, nearly four times that of ethanol-ICE. In the long term, a small fraction of the annual US biomass (e.g., 7.1%, or 700 million tons of biomass) would be sufficient to meet 100% of light-duty passenger vehicle fuel needs (i.e., 150 billion gallons of gasoline/ethanol per year), through up to four-fold enhanced BTW efficiencies by using SFCV or BEV. SFCV would have several advantages over BEV: much higher energy storage densities, faster refilling rates, better safety, and less environmental burdens.

The establishment of Saccharomyces boulardii surface display system using a single expression vector.

Science.gov (United States)

Wang, Tiantian; Sun, Hui; Zhang, Jie; Liu, Qing; Wang, Longjiang; Chen, Peipei; Wang, Fangkun; Li, Hongmei; Xiao, Yihong; Zhao, Xiaomin

2014-03-01

In the present study, an a-agglutinin-based Saccharomyces boulardii surface display system was successfully established using a single expression vector. Based on the two protein co-expression vector pSP-G1 built by Partow et al., a S. boulardii surface display vector-pSDSb containing all the display elements was constructed. The display results of heterologous proteins were confirmed by successfully displaying enhanced green fluorescent protein (EGFP) and chicken Eimeria tenella Microneme-2 proteins (EtMic2) on the S. boulardii cell surface. The DNA sequence of AGA1 gene from S. boulardii (SbAGA1) was determined and used as the cell wall anchor partner. This is the first time heterologous proteins have been displayed on the cell surface of S. boulardii. Because S. boulardii is probiotic and eukaryotic, its surface display system would be very valuable, particularly in the development of a live vaccine against various pathogenic organisms especially eukaryotic pathogens such as protistan parasites. Copyright © 2013 Elsevier Inc. All rights reserved.

Vector 33: A reduce program for vector algebra and calculus in orthogonal curvilinear coordinates

Science.gov (United States)

Harper, David

1989-06-01

This paper describes a package with enables REDUCE 3.3 to perform algebra and calculus operations upon vectors. Basic algebraic operations between vectors and between scalars and vectors are provided, including scalar (dot) product and vector (cross) product. The vector differential operators curl, divergence, gradient and Laplacian are also defined, and are valid in any orthogonal curvilinear coordinate system. The package is written in RLISP to allow algebra and calculus to be performed using notation identical to that for operations. Scalars and vectors can be mixed quite freely in the same expression. The package will be of interest to mathematicians, engineers and scientists who need to perform vector calculations in orthogonal curvilinear coordinates.

Output-only modal parameter estimator of linear time-varying structural systems based on vector TAR model and least squares support vector machine

Science.gov (United States)

Zhou, Si-Da; Ma, Yuan-Chen; Liu, Li; Kang, Jie; Ma, Zhi-Sai; Yu, Lei

2018-01-01

Identification of time-varying modal parameters contributes to the structural health monitoring, fault detection, vibration control, etc. of the operational time-varying structural systems. However, it is a challenging task because there is not more information for the identification of the time-varying systems than that of the time-invariant systems. This paper presents a vector time-dependent autoregressive model and least squares support vector machine based modal parameter estimator for linear time-varying structural systems in case of output-only measurements. To reduce the computational cost, a Wendland's compactly supported radial basis function is used to achieve the sparsity of the Gram matrix. A Gamma-test-based non-parametric approach of selecting the regularization factor is adapted for the proposed estimator to replace the time-consuming n-fold cross validation. A series of numerical examples have illustrated the advantages of the proposed modal parameter estimator on the suppression of the overestimate and the short data. A laboratory experiment has further validated the proposed estimator.

Elliptic-symmetry vector optical fields.

Science.gov (United States)

Pan, Yue; Li, Yongnan; Li, Si-Min; Ren, Zhi-Cheng; Kong, Ling-Jun; Tu, Chenghou; Wang, Hui-Tian

2014-08-11

We present in principle and demonstrate experimentally a new kind of vector fields: elliptic-symmetry vector optical fields. This is a significant development in vector fields, as this breaks the cylindrical symmetry and enriches the family of vector fields. Due to the presence of an additional degrees of freedom, which is the interval between the foci in the elliptic coordinate system, the elliptic-symmetry vector fields are more flexible than the cylindrical vector fields for controlling the spatial structure of polarization and for engineering the focusing fields. The elliptic-symmetry vector fields can find many specific applications from optical trapping to optical machining and so on.

Multi-disease data management system platform for vector-borne diseases.

Directory of Open Access Journals (Sweden)

Lars Eisen

2011-03-01

Full Text Available Emerging information technologies present new opportunities to reduce the burden of malaria, dengue and other infectious diseases. For example, use of a data management system software package can help disease control programs to better manage and analyze their data, and thus enhances their ability to carry out continuous surveillance, monitor interventions and evaluate control program performance.We describe a novel multi-disease data management system platform (hereinafter referred to as the system with current capacity for dengue and malaria that supports data entry, storage and query. It also allows for production of maps and both standardized and customized reports. The system is comprised exclusively of software components that can be distributed without the user incurring licensing costs. It was designed to maximize the ability of the user to adapt the system to local conditions without involvement of software developers. Key points of system adaptability include 1 customizable functionality content by disease, 2 configurable roles and permissions, 3 customizable user interfaces and display labels and 4 configurable information trees including a geographical entity tree and a term tree. The system includes significant portions of functionality that is entirely or in large part re-used across diseases, which provides an economy of scope as new diseases downstream are added to the system at decreased cost.We have developed a system with great potential for aiding disease control programs in their task to reduce the burden of dengue and malaria, including the implementation of integrated vector management programs. Next steps include evaluations of operational implementations of the current system with capacity for dengue and malaria, and the inclusion in the system platform of other important vector-borne diseases.

A classification system for one Killing vector solutions of Einstein's equations

International Nuclear Information System (INIS)

Hoenselaers, C.

1978-01-01

A double classification system for one Killing vector solutions in terms of the eigenvectors and eigenvalues of the Ricci and Bach tensor of the associated three manifold is proposed. The calculations of the Bach tensor are carried out for special cases. (author)

Ultrasound Vector Flow Imaging: Part I: Sequential Systems

DEFF Research Database (Denmark)

Jensen, Jørgen Arendt; Nikolov, Svetoslav Ivanov; Yu, Alfred C. H.

2016-01-01

, and variants of these. The review covers both 2-D and 3-D velocity estimation and gives a historical perspective on the development along with a summary of various vector flow visualization algorithms. The current state-of-the-art is explained along with an overview of clinical studies conducted and methods......The paper gives a review of the most important methods for blood velocity vector flow imaging (VFI) for conventional, sequential data acquisition. This includes multibeam methods, speckle tracking, transverse oscillation, color flow mapping derived vector flow imaging, directional beamforming...

Algevir: An Expression System for Microalgae Based on Viral Vectors

Directory of Open Access Journals (Sweden)

Bernardo Bañuelos-Hernández

2017-06-01

Full Text Available The use of recombinant algae for the production of valuable compounds is opening promising biotechnological applications. However, the development of efficient expression approaches is still needed to expand the exploitation of microalgae in biotechnology. Herein, the concept of using viral expression vectors in microalgae was explored for the first time. An inducible geminiviral vector leading to Rep-mediated replication of the expression cassette allowed the production of antigenic proteins at high levels. This system, called Algevir, allows the production of complex viral proteins (GP1 from Zaire ebolavirus and bacterial toxin subunits (B subunit of the heat-labile Escherichia coli enterotoxin, which retained their antigenic activity. The highest achieved yield was 1.25 mg/g fresh biomass (6 mg/L of culture, which was attained 3 days after transformation. The Algevir system allows for a fast and efficient production of recombinant proteins, overcoming the difficulties imposed by the low yields and unstable expression patterns frequently observed in stably transformed microalgae at the nuclear level; as well as the toxicity of some target proteins.

Algevir: An Expression System for Microalgae Based on Viral Vectors

Science.gov (United States)

Bañuelos-Hernández, Bernardo; Monreal-Escalante, Elizabeth; González-Ortega, Omar; Angulo, Carlos; Rosales-Mendoza, Sergio

2017-01-01

The use of recombinant algae for the production of valuable compounds is opening promising biotechnological applications. However, the development of efficient expression approaches is still needed to expand the exploitation of microalgae in biotechnology. Herein, the concept of using viral expression vectors in microalgae was explored for the first time. An inducible geminiviral vector leading to Rep-mediated replication of the expression cassette allowed the production of antigenic proteins at high levels. This system, called Algevir, allows the production of complex viral proteins (GP1 from Zaire ebolavirus) and bacterial toxin subunits (B subunit of the heat-labile Escherichia coli enterotoxin), which retained their antigenic activity. The highest achieved yield was 1.25 mg/g fresh biomass (6 mg/L of culture), which was attained 3 days after transformation. The Algevir system allows for a fast and efficient production of recombinant proteins, overcoming the difficulties imposed by the low yields and unstable expression patterns frequently observed in stably transformed microalgae at the nuclear level; as well as the toxicity of some target proteins. PMID:28713333

"Lollipop-shaped" high-sensitivity Microelectromechanical Systems vector hydrophone based on Parylene encapsulation

Science.gov (United States)

Liu, Yuan; Wang, Renxin; Zhang, Guojun; Du, Jin; Zhao, Long; Xue, Chenyang; Zhang, Wendong; Liu, Jun

2015-07-01

This paper presents methods of promoting the sensitivity of Microelectromechanical Systems (MEMS) vector hydrophone by increasing the sensing area of cilium and perfect insulative Parylene membrane. First, a low-density sphere is integrated with the cilium to compose a "lollipop shape," which can considerably increase the sensing area. A mathematic model on the sensitivity of the "lollipop-shaped" MEMS vector hydrophone is presented, and the influences of different structural parameters on the sensitivity are analyzed via simulation. Second, the MEMS vector hydrophone is encapsulated through the conformal deposition of insulative Parylene membrane, which enables underwater acoustic monitoring without any typed sound-transparent encapsulation. Finally, the characterization results demonstrate that the sensitivity reaches up to -183 dB (500 Hz 0dB at 1 V/ μPa ), which is increased by more than 10 dB, comparing with the previous cilium-shaped MEMS vector hydrophone. Besides, the frequency response takes on a sensitivity increment of 6 dB per octave. The working frequency band is 20-500 Hz and the concave point depth of 8-shaped directivity is beyond 30 dB, indicating that the hydrophone is promising in underwater acoustic application.

On-line transient stability assessment of large-scale power systems by using ball vector machines

International Nuclear Information System (INIS)

Mohammadi, M.; Gharehpetian, G.B.

2010-01-01

In this paper ball vector machine (BVM) has been used for on-line transient stability assessment of large-scale power systems. To classify the system transient security status, a BVM has been trained for all contingencies. The proposed BVM based security assessment algorithm has very small training time and space in comparison with artificial neural networks (ANN), support vector machines (SVM) and other machine learning based algorithms. In addition, the proposed algorithm has less support vectors (SV) and therefore is faster than existing algorithms for on-line applications. One of the main points, to apply a machine learning method is feature selection. In this paper, a new Decision Tree (DT) based feature selection technique has been presented. The proposed BVM based algorithm has been applied to New England 39-bus power system. The simulation results show the effectiveness and the stability of the proposed method for on-line transient stability assessment procedure of large-scale power system. The proposed feature selection algorithm has been compared with different feature selection algorithms. The simulation results demonstrate the effectiveness of the proposed feature algorithm.

Selection vector filter framework

Science.gov (United States)

Lukac, Rastislav; Plataniotis, Konstantinos N.; Smolka, Bogdan; Venetsanopoulos, Anastasios N.

2003-10-01

We provide a unified framework of nonlinear vector techniques outputting the lowest ranked vector. The proposed framework constitutes a generalized filter class for multichannel signal processing. A new class of nonlinear selection filters are based on the robust order-statistic theory and the minimization of the weighted distance function to other input samples. The proposed method can be designed to perform a variety of filtering operations including previously developed filtering techniques such as vector median, basic vector directional filter, directional distance filter, weighted vector median filters and weighted directional filters. A wide range of filtering operations is guaranteed by the filter structure with two independent weight vectors for angular and distance domains of the vector space. In order to adapt the filter parameters to varying signal and noise statistics, we provide also the generalized optimization algorithms taking the advantage of the weighted median filters and the relationship between standard median filter and vector median filter. Thus, we can deal with both statistical and deterministic aspects of the filter design process. It will be shown that the proposed method holds the required properties such as the capability of modelling the underlying system in the application at hand, the robustness with respect to errors in the model of underlying system, the availability of the training procedure and finally, the simplicity of filter representation, analysis, design and implementation. Simulation studies also indicate that the new filters are computationally attractive and have excellent performance in environments corrupted by bit errors and impulsive noise.

Effective data compaction algorithm for vector scan EB writing system

Science.gov (United States)

Ueki, Shinichi; Ashida, Isao; Kawahira, Hiroichi

2001-01-01

We have developed a new mask data compaction algorithm dedicated to vector scan electron beam (EB) writing systems for 0.13 μm device generation. Large mask data size has become a significant problem at mask data processing for which data compaction is an important technique. In our new mask data compaction, 'array' representation and 'cell' representation are used. The mask data format for the EB writing system with vector scan supports these representations. The array representation has a pitch and a number of repetitions in both X and Y direction. The cell representation has a definition of figure group and its reference. The new data compaction method has the following three steps. (1) Search arrays of figures by selecting pitches of array so that a number of figures are included. (2) Find out same arrays that have same repetitive pitch and number of figures. (3) Search cells of figures, where the figures in each cell take identical positional relationship. By this new method for the mask data of a 4M-DRAM block gate layer with peripheral circuits, 202 Mbytes without compaction was highly compacted to 6.7 Mbytes in 20 minutes on a 500 MHz PC.

Vector-valued measure and the necessary conditions for the optimal control problems of linear systems

International Nuclear Information System (INIS)

Xunjing, L.

1981-12-01

The vector-valued measure defined by the well-posed linear boundary value problems is discussed. The maximum principle of the optimal control problem with non-convex constraint is proved by using the vector-valued measure. Especially, the necessary conditions of the optimal control of elliptic systems is derived without the convexity of the control domain and the cost function. (author)

Meromorphic Vector Fields and Circle Packings

DEFF Research Database (Denmark)

Dias, Kealey

The objective of the Ph.D. project is to initiate a classification of bifurcations of meromorphic vector fields and to clarify their relation to circle packings. Technological applications are to image analysis and to effective grid generation using discrete conformal mappings. The two branches...... of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions or meromorphic (allowing poles...... as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic vector fields. Restricting...

Adeno-associated viral vectors as agents for gene delivery : application in disorders and trauma of the central nervous system

NARCIS (Netherlands)

Ruitenberg, Marc J; Eggers, Ruben; Boer, Gerard J; Verhaagen, J.

2002-01-01

The use of viral vectors as agents for gene delivery provides a direct approach to manipulate gene expression in the mammalian central nervous system (CNS). The present article describes in detail the methodology for the injection of viral vectors, in particular adeno-associated virus (AAV) vectors,

CW-THz vector spectroscopy and imaging system based on 1.55-µm fiber-optics.

Science.gov (United States)

Kim, Jae-Young; Song, Ho-Jin; Yaita, Makoto; Hirata, Akihiko; Ajito, Katsuhiro

2014-01-27

We present a continuous-wave terahertz (THz) vector spectroscopy and imaging system based on a 1.5-µm fiber optic uni-traveling-carrier photodiode and InGaAs photo-conductive receiver. Using electro-optic (EO) phase modulators for THz phase control with shortened optical paths, the system achieves fast vector measurement with effective phase stabilization. Dynamic ranges of 100 dB · Hz and 75 dB · Hz at 300 GHz and 1 THz, and phase stability of 1.5° per minute are obtained. With the simultaneous measurement of absorbance and relative permittivity, we demonstrate non-destructive analyses of pharmaceutical cocrystals inside tablets within a few minutes.

Large-scale deployment of electric vehicles in Germany by 2030: An analysis of grid-to-vehicle and vehicle-to-grid concepts

International Nuclear Information System (INIS)

Loisel, Rodica; Pasaoglu, Guzay; Thiel, Christian

2014-01-01

This study analyses battery electric vehicles (BEVs) in the future German power system and makes projections of the BEVs hourly load profile by car size (‘mini’, ‘small’, ‘compact’ and ‘large’). By means of a power plant dispatching optimisation model, the study assesses the optimal BEV charging/discharging strategies in grid-to-vehicle (G2V) and vehicle-to-grid (V2G) schemes. The results show that the 2% rise in power demand required to power these BEVs does not hamper system stability provided an optimal G2V scheme is applied. Moreover, such BEV deployment can contribute to further integrating wind and solar power generation. Applying a V2G scheme would increase the capacity factors of base and mid-load power plants, leading to a higher integration of intermittent renewables and resulting in a decrease in system costs. However, the evaluation of the profitability of BEVs shows that applying a V2G scheme is not a viable economic option due to the high cost of investing in batteries. Some BEV owners would make modest profits (€6 a year), but a higher number would sustain losses, for reasons of scale. For BEVs to become part of the power system, further incentives are necessary to make the business model attractive to car owners. - Highlights: • Optimal strategies for charging/discharging battery electric vehicles are assessed. • G2V scheme improves the stability of the future German power system. • V2G scheme would increase the capacity factors of base and mid-load power plants. • V2G scheme is not a viable economic option due to high batteries investment cost. • Further incentives are necessary to make the business model attractive to car owners

Design and Potential of Non-Integrating Lentiviral Vectors

Directory of Open Access Journals (Sweden)

Aaron Shaw

2014-01-01

Full Text Available Lentiviral vectors have demonstrated promising results in clinical trials that target cells of the hematopoietic system. For these applications, they are the vectors of choice since they provide stable integration into cells that will undergo extensive expansion in vivo. Unfortunately, integration can have unintended consequences including dysregulated cell growth. Therefore, lentiviral vectors that do not integrate are predicted to have a safer profile compared to integrating vectors and should be considered for applications where transient expression is required or for sustained episomal expression such as in quiescent cells. In this review, the system for generating lentiviral vectors will be described and used to illustrate how alterations in the viral integrase or vector Long Terminal Repeats have been used to generate vectors that lack the ability to integrate. In addition to their safety advantages, these non-integrating lentiviral vectors can be used when persistent expression would have adverse consequences. Vectors are currently in development for use in vaccinations, cancer therapy, site-directed gene insertions, gene disruption strategies, and cell reprogramming. Preclinical work will be described that illustrates the potential of this unique vector system in human gene therapy.

Implementation of a vector-based tracking loop receiver in a pseudolite navigation system.

Science.gov (United States)

So, Hyoungmin; Lee, Taikjin; Jeon, Sanghoon; Kim, Chongwon; Kee, Changdon; Kim, Taehee; Lee, Sanguk

2010-01-01

We propose a vector tracking loop (VTL) algorithm for an asynchronous pseudolite navigation system. It was implemented in a software receiver and experiments in an indoor navigation system were conducted. Test results show that the VTL successfully tracks signals against the near-far problem, one of the major limitations in pseudolite navigation systems, and could improve positioning availability by extending pseudolite navigation coverage.

Misalignment calibration of geomagnetic vector measurement system using parallelepiped frame rotation method

International Nuclear Information System (INIS)

Pang, Hongfeng; Zhu, XueJun; Pan, Mengchun; Zhang, Qi; Wan, Chengbiao; Luo, Shitu; Chen, Dixiang; Chen, Jinfei; Li, Ji; Lv, Yunxiao

2016-01-01

Misalignment error is one key factor influencing the measurement accuracy of geomagnetic vector measurement system, which should be calibrated with the difficulties that sensors measure different physical information and coordinates are invisible. A new misalignment calibration method by rotating a parallelepiped frame is proposed. Simulation and experiment result show the effectiveness of calibration method. The experimental system mainly contains DM-050 three-axis fluxgate magnetometer, INS (inertia navigation system), aluminium parallelepiped frame, aluminium plane base. Misalignment angles are calculated by measured data of magnetometer and INS after rotating the aluminium parallelepiped frame on aluminium plane base. After calibration, RMS error of geomagnetic north, vertical and east are reduced from 349.441 nT, 392.530 nT and 562.316 nT to 40.130 nT, 91.586 nT and 141.989 nT respectively. - Highlights: • A new misalignment calibration method by rotating a parallelepiped frame is proposed. • It does not need to know sensor attitude information or local dip angle. • The calibration system attitude change angle is not strictly required. • It can be widely used when sensors measure different physical information. • Geomagnetic vector measurement error is reduced evidently.

Misalignment calibration of geomagnetic vector measurement system using parallelepiped frame rotation method

Energy Technology Data Exchange (ETDEWEB)

Pang, Hongfeng [Academy of Equipment, Beijing 101416 (China); College of Mechatronics Engineering and Automation, National University of Defense Technology, Changsha 410073 (China); Zhu, XueJun, E-mail: zhuxuejun1990@126.com [College of Mechatronics Engineering and Automation, National University of Defense Technology, Changsha 410073 (China); Pan, Mengchun; Zhang, Qi; Wan, Chengbiao; Luo, Shitu; Chen, Dixiang; Chen, Jinfei; Li, Ji; Lv, Yunxiao [College of Mechatronics Engineering and Automation, National University of Defense Technology, Changsha 410073 (China)

2016-12-01

Misalignment error is one key factor influencing the measurement accuracy of geomagnetic vector measurement system, which should be calibrated with the difficulties that sensors measure different physical information and coordinates are invisible. A new misalignment calibration method by rotating a parallelepiped frame is proposed. Simulation and experiment result show the effectiveness of calibration method. The experimental system mainly contains DM-050 three-axis fluxgate magnetometer, INS (inertia navigation system), aluminium parallelepiped frame, aluminium plane base. Misalignment angles are calculated by measured data of magnetometer and INS after rotating the aluminium parallelepiped frame on aluminium plane base. After calibration, RMS error of geomagnetic north, vertical and east are reduced from 349.441 nT, 392.530 nT and 562.316 nT to 40.130 nT, 91.586 nT and 141.989 nT respectively. - Highlights: • A new misalignment calibration method by rotating a parallelepiped frame is proposed. • It does not need to know sensor attitude information or local dip angle. • The calibration system attitude change angle is not strictly required. • It can be widely used when sensors measure different physical information. • Geomagnetic vector measurement error is reduced evidently.

Usability Evaluation of an Augmented Reality System for Teaching Euclidean Vectors

Science.gov (United States)

Martin-Gonzalez, Anabel; Chi-Poot, Angel; Uc-Cetina, Victor

2016-01-01

Augmented reality (AR) is one of the emerging technologies that has demonstrated to be an efficient technological tool to enhance learning techniques. In this paper, we describe the development and evaluation of an AR system for teaching Euclidean vectors in physics and mathematics. The goal of this pedagogical tool is to facilitate user's…

A multi vector energy analysis for interconnected power and gas systems

International Nuclear Information System (INIS)

Devlin, Joseph; Li, Kang; Higgins, Paraic; Foley, Aoife

2017-01-01

Highlights: • The first multi vector energy system analysis for Britain and Ireland is performed. • Extreme weather driven gas demands were utilised to increase gas system stress. • GB gas system is capable of satisfying demand but restricts gas generator ramping. • Irish gas system congestion causes a 40% increase in gas generator short run cost. • Gas storage in Ireland relieved congestion reduced operational costs by 14%. - Abstract: This paper presents the first multi vector energy analysis for the interconnected energy systems of Great Britain (GB) and Ireland. Both systems share a common high penetration of wind power, but significantly different security of supply outlooks. Ireland is heavily dependent on gas imports from GB, giving significance to the interconnected aspect of the methodology in addition to the gas and power interactions analysed. A fully realistic unit commitment and economic dispatch model coupled to an energy flow model of the gas supply network is developed. Extreme weather events driving increased domestic gas demand and low wind power output were utilised to increase gas supply network stress. Decreased wind profiles had a larger impact on system security than high domestic gas demand. However, the GB energy system was resilient during high demand periods but gas network stress limited the ramping capability of localised generating units. Additionally, gas system entry node congestion in the Irish system was shown to deliver a 40% increase in short run costs for generators. Gas storage was shown to reduce the impact of high demand driven congestion delivering a reduction in total generation costs of 14% in the period studied and reducing electricity imports from GB, significantly contributing to security of supply.

Evaluation of systemic insecticides mixed in rodenticide baits for plague vector control

DEFF Research Database (Denmark)

Larsen, Kim Søholt; Lodal, Jens

1997-01-01

Rodenticide baits containing systemic insecticides were evaluated in the laboratory for their palatability to the house rat Rattus rattus and for their toxicity against the oriental rat flea Xenopsylla cheopis - both animals are important Vectors of plague in Africa. The test bait and a non...

A simple and robust vector-based shRNA expression system used for RNA interference.

Science.gov (United States)

Wang, Xue-jun; Li, Ying; Huang, Hai; Zhang, Xiu-juan; Xie, Pei-wen; Hu, Wei; Li, Dan-dan; Wang, Sheng-qi

2013-01-01

RNA interference (RNAi) mediated by small interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) has become a powerful genetic tool for conducting functional studies. Previously, vector-based shRNA-expression strategies capable of inducing RNAi in viable cells have been developed, however, these vector systems have some disadvantages, either because they were error-prone or cost prohibitive. In this report we described the development of a simple, robust shRNA expression system utilizing 1 long oligonucleotide or 2 short oligonucleotides for half the cost of conventional shRNA construction methods and with a >95% cloning success rate. The shRNA loop sequence and stem structure were also compared and carefully selected for better RNAi efficiency. Furthermore, an easier strategy was developed based on isocaudomers which permit rapid combination of the most efficient promoter-shRNA cassettes. Finally, using this method, the conservative target sites for hepatitis B virus (HBV) knockdown were systemically screened and HBV antigen expression shown to be successfully suppressed in the presence of connected multiple shRNAs both in vitro and in vivo. This novel design describes an inexpensive and effective way to clone and express single or multiple shRNAs from the same vector with the capacity for potent and effective silencing of target genes.

A Fiber-Optic Borehole Seismic Vector Sensor System for Geothermal Site Characterization and Monitoring

Energy Technology Data Exchange (ETDEWEB)

Paulsson, Bjorn N.P. [Paulsson, Inc., Van Nuys, CA (United States); Thornburg, Jon A. [Paulsson, Inc., Van Nuys, CA (United States); He, Ruiqing [Paulsson, Inc., Van Nuys, CA (United States)

2015-04-21

Seismic techniques are the dominant geophysical techniques for the characterization of subsurface structures and stratigraphy. The seismic techniques also dominate the monitoring and mapping of reservoir injection and production processes. Borehole seismology, of all the seismic techniques, despite its current shortcomings, has been shown to provide the highest resolution characterization and most precise monitoring results because it generates higher signal to noise ratio and higher frequency data than surface seismic techniques. The operational environments for borehole seismic instruments are however much more demanding than for surface seismic instruments making both the instruments and the installation much more expensive. The current state-of-the-art borehole seismic instruments have not been robust enough for long term monitoring compounding the problems with expensive instruments and installations. Furthermore, they have also not been able to record the large bandwidth data available in boreholes or having the sensitivity allowing them to record small high frequency micro seismic events with high vector fidelity. To reliably achieve high resolution characterization and long term monitoring of Enhanced Geothermal Systems (EGS) sites a new generation of borehole seismic instruments must therefore be developed and deployed. To address the critical site characterization and monitoring needs for EGS programs, US Department of Energy (DOE) funded Paulsson, Inc. in 2010 to develop a fiber optic based ultra-large bandwidth clamped borehole seismic vector array capable of deploying up to one thousand 3C sensor pods suitable for deployment into ultra-high temperature and high pressure boreholes. Tests of the fiber optic seismic vector sensors developed on the DOE funding have shown that the new borehole seismic sensor technology is capable of generating outstanding high vector fidelity data with extremely large bandwidth: 0.01 – 6,000 Hz. Field tests have shown

A sustainability assessment of electric vehicles as a personal mobility system

International Nuclear Information System (INIS)

Faria, Ricardo; Moura, Pedro; Delgado, Joaquim; Almeida, Anibal T. de

2012-01-01

Highlights: ► Ownership cost and CO 2 emissions for electric and internal combustion engine vehicles. ► Well-to-Wheel energy assessment in electric vehicles. ► Main factors that contribute to overall energy consumption. ► Real world experiments to characterize electric vehicles energy consumption. - Abstract: This paper presents a study of the economic and environmental balances for Electric Vehicles (EVs) versus Internal Combustion Engine Vehicle (ICEV). The analyses were based on the Well-to-Wheel (WTW) methodology, a specific type of Life Cycle Assessment (LCA). WTW balances were carried out taking into account different scenarios for the primary energy supply and different vehicle technologies. The primary energy supply includes non-renewable sources (fossil fuels and nuclear) and Renewable Energy Source (RES). Vehicle technologies include Battery Electric Vehicle (BEV), Hybrid Electric Vehicle (HEV) and Plug-in Hybrid Electric Vehicle (PHEV). The generation scenarios considered in the study include the present European Union (EU) average mix and a planned increasing contribution from RESs. For the BEV, several real world driving cycle scenarios were investigated, using a custom built data acquisition system, in order to characterize the main factors that contribute to the overall energy consumption, associated cost and emissions. In terms of environmental impact, for the average EU electricity mix, BEVs have less than a half of the emissions than an ICEV. However, the ownership costs during its life cycle (about 10 y) are similar to an equivalent ICEV, despite the lower operational costs for BEVs. The likely battery price reduction, leading to a lower investment cost, will gradually tip the balance in favour of EVs.

Using Vector and Extended Boolean Matching in an Expert System for Selecting Foster Homes.

Science.gov (United States)

Fox, Edward A.; Winett, Sheila G.

1990-01-01

Describes FOCES (Foster Care Expert System), a prototype expert system for choosing foster care placements for children which integrates information retrieval techniques with artificial intelligence. The use of prototypes and queries in Prolog routines, extended Boolean matching, and vector correlation are explained, as well as evaluation by…

Effective genetic modification and differentiation of hMSCs upon controlled release of rAAV vectors using alginate/poloxamer composite systems.

Science.gov (United States)

Díaz-Rodríguez, P; Rey-Rico, A; Madry, H; Landin, M; Cucchiarini, M

2015-12-30

Viral vectors are common tools in gene therapy to deliver foreign therapeutic sequences in a specific target population via their natural cellular entry mechanisms. Incorporating such vectors in implantable systems may provide strong alternatives to conventional gene transfer procedures. The goal of the present study was to generate different hydrogel structures based on alginate (AlgPH155) and poloxamer PF127 as new systems to encapsulate and release recombinant adeno-associated viral (rAAV) vectors. Inclusion of rAAV in such polymeric capsules revealed an influence of the hydrogel composition and crosslinking temperature upon the vector release profiles, with alginate (AlgPH155) structures showing the fastest release profiles early on while over time vector release was more effective from AlgPH155+PF127 [H] capsules crosslinked at a high temperature (50°C). Systems prepared at room temperature (AlgPH155+PF127 [C]) allowed instead to achieve a more controlled release profile. When tested for their ability to target human mesenchymal stem cells, the different systems led to high transduction efficiencies over time and to gene expression levels in the range of those achieved upon direct vector application, especially when using AlgPH155+PF127 [H]. No detrimental effects were reported on either cell viability or on the potential for chondrogenic differentiation. Inclusion of PF127 in the capsules was also capable of delaying undesirable hypertrophic cell differentiation. These findings are of promising value for the further development of viral vector controlled release strategies. Copyright © 2015 Elsevier B.V. All rights reserved.

Generalized correlation integral vectors: A distance concept for chaotic dynamical systems

Energy Technology Data Exchange (ETDEWEB)

Haario, Heikki, E-mail: heikki.haario@lut.fi [School of Engineering Science, Lappeenranta University of Technology, Lappeenranta (Finland); Kalachev, Leonid, E-mail: KalachevL@mso.umt.edu [Department of Mathematical Sciences, University of Montana, Missoula, Montana 59812-0864 (United States); Hakkarainen, Janne [Earth Observation Unit, Finnish Meteorological Institute, Helsinki (Finland)

2015-06-15

Several concepts of fractal dimension have been developed to characterise properties of attractors of chaotic dynamical systems. Numerical approximations of them must be calculated by finite samples of simulated trajectories. In principle, the quantities should not depend on the choice of the trajectory, as long as it provides properly distributed samples of the underlying attractor. In practice, however, the trajectories are sensitive with respect to varying initial values, small changes of the model parameters, to the choice of a solver, numeric tolerances, etc. The purpose of this paper is to present a statistically sound approach to quantify this variability. We modify the concept of correlation integral to produce a vector that summarises the variability at all selected scales. The distribution of this stochastic vector can be estimated, and it provides a statistical distance concept between trajectories. Here, we demonstrate the use of the distance for the purpose of estimating model parameters of a chaotic dynamic model. The methodology is illustrated using computational examples for the Lorenz 63 and Lorenz 95 systems, together with a framework for Markov chain Monte Carlo sampling to produce posterior distributions of model parameters.

A simple and robust vector-based shRNA expression system used for RNA interference.

Directory of Open Access Journals (Sweden)

Xue-jun Wang

Full Text Available BACKGROUND: RNA interference (RNAi mediated by small interfering RNAs (siRNAs or short hairpin RNAs (shRNAs has become a powerful genetic tool for conducting functional studies. Previously, vector-based shRNA-expression strategies capable of inducing RNAi in viable cells have been developed, however, these vector systems have some disadvantages, either because they were error-prone or cost prohibitive. RESULTS: In this report we described the development of a simple, robust shRNA expression system utilizing 1 long oligonucleotide or 2 short oligonucleotides for half the cost of conventional shRNA construction methods and with a >95% cloning success rate. The shRNA loop sequence and stem structure were also compared and carefully selected for better RNAi efficiency. Furthermore, an easier strategy was developed based on isocaudomers which permit rapid combination of the most efficient promoter-shRNA cassettes. Finally, using this method, the conservative target sites for hepatitis B virus (HBV knockdown were systemically screened and HBV antigen expression shown to be successfully suppressed in the presence of connected multiple shRNAs both in vitro and in vivo. CONCLUSION: This novel design describes an inexpensive and effective way to clone and express single or multiple shRNAs from the same vector with the capacity for potent and effective silencing of target genes.

Vectorization, parallelization and porting of nuclear codes on the VPP500 system (porting). Progress report fiscal 1997

International Nuclear Information System (INIS)

Ishizuki, Shigeru; Nemoto, Toshiyuki; Kawai, Wataru; Watanabe, Hideo; Tanabe, Hidenobu; Kawasaki, Nobuo; Adachi, Masaaki; Ogasawara, Shinobu; Kume, Etsuo

1999-05-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system and/or the AP3000 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 14 codes in fiscal 1997. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the porting. In this porting part, the porting of transient reactor analysis code TRAC-BF1 and Monte Carlo radiation transport code MCNP4A on the AP3000 are described. In addition, a modification of program libraries for command-driven interactive data analysis plotting program IPLOT is described. In the vectorization part, the vectorization of multidimensional two-fluid model code ACE-3D for evaluation of constitutive equations, statistical decay code SD and three-dimensional thermal analysis code for in-core test section (T2) of HENDEL SSPHEAT are described. In the parallelization part, the parallelization of cylindrical direct numerical simulation code CYLDNS44N, worldwide version of system for prediction of environmental emergency dose information code WSPEEDI, extension of quantum molecular dynamics code EQMD and three-dimensional non-steady compressible fluid dynamics code STREAM are described. (author)

EU-domme med bemærkninger og spørgsmål - 3. udgave

DEFF Research Database (Denmark)

Broberg, Morten Petersen

EU-ret, fri bevægelighed, varernes fri bevægelighed, fri bevægelighed for tjenesteydelser, fri bevægelse for personer, arbejdskraftens fri bevægelighed, den fri etableringsret, kapitalens fri bevægelighed......EU-ret, fri bevægelighed, varernes fri bevægelighed, fri bevægelighed for tjenesteydelser, fri bevægelse for personer, arbejdskraftens fri bevægelighed, den fri etableringsret, kapitalens fri bevægelighed...

Relativistic gravitation from massless systems of scalar and vector fields

International Nuclear Information System (INIS)

Fonseca Teixeira, A.F. da.

1979-01-01

Under the laws of Einstein's gravitational theory, a massless system consisting of the diffuse sources of two fields is discussed. One fields is scalar, of long range, the other is a vector field of short range. A proportionality between the sources is assumed. Both fields are minimally coupled to gravitation, and contribute positive definitely to the time component of the energy momentum tensor. A class of static, spherically symmetric solutions of the equations is obtained, in the weak field limit. The solutions are regular everywhere, stable, and can represent large or small physical systems. The gravitational field presents a Schwarzschild-type asymptotic behavior. The dependence of the energy on the various parameters characterizing the system is discussed in some detail. (Author) [pt

Design of a mixer for the thrust-vectoring system on the high-alpha research vehicle

Science.gov (United States)

Pahle, Joseph W.; Bundick, W. Thomas; Yeager, Jessie C.; Beissner, Fred L., Jr.

1996-01-01

One of the advanced control concepts being investigated on the High-Alpha Research Vehicle (HARV) is multi-axis thrust vectoring using an experimental thrust-vectoring (TV) system consisting of three hydraulically actuated vanes per engine. A mixer is used to translate the pitch-, roll-, and yaw-TV commands into the appropriate TV-vane commands for distribution to the vane actuators. A computer-aided optimization process was developed to perform the inversion of the thrust-vectoring effectiveness data for use by the mixer in performing this command translation. Using this process a new mixer was designed for the HARV and evaluated in simulation and flight. An important element of the Mixer is the priority logic, which determines priority among the pitch-, roll-, and yaw-TV commands.

CO2 Mitigation Potential of Plug-in Hybrid Electric Vehicles larger than expected.

Science.gov (United States)

Plötz, P; Funke, S A; Jochem, P; Wietschel, M

2017-11-28

The actual contribution of plug-in hybrid and battery electric vehicles (PHEV and BEV) to greenhouse gas mitigation depends on their real-world usage. Often BEV are seen as superior as they drive only electrically and do not have any direct emissions during driving. However, empirical evidence on which vehicle electrifies more mileage with a given battery capacity is lacking. Here, we present the first systematic overview of empirical findings on actual PHEV and BEV usage for the US and Germany. Contrary to common belief, PHEV with about 60 km of real-world range currently electrify as many annual vehicles kilometres as BEV with a much smaller battery. Accordingly, PHEV recharged from renewable electricity can highly contribute to green house gas mitigation in car transport. Including the higher CO 2eq emissions during the production phase of BEV compared to PHEV, PHEV show today higher CO 2eq savings then BEVs compared to conventional vehicles. However, for significant CO 2eq improvements of PHEV and particularly of BEVs the decarbonisation of the electricity system should go on.

Scanning vector Hall probe microscopy

International Nuclear Information System (INIS)

Cambel, V.; Gregusova, D.; Fedor, J.; Kudela, R.; Bending, S.J.

2004-01-01

We have developed a scanning vector Hall probe microscope for mapping magnetic field vector over magnetic samples. The microscope is based on a micromachined Hall sensor and the cryostat with scanning system. The vector Hall sensor active area is ∼5x5 μm 2 . It is realized by patterning three Hall probes on the tilted faces of GaAs pyramids. Data from these 'tilted' Hall probes are used to reconstruct the full magnetic field vector. The scanning area of the microscope is 5x5 mm 2 , space resolution 2.5 μm, field resolution ∼1 μT Hz -1/2 at temperatures 10-300 K

Vector mesons on the light front

International Nuclear Information System (INIS)

Naito, K.; Maedan, S.; Itakura, K.

2004-01-01

We apply the light-front quantization to the Nambu-Jona-Lasinio model with the vector interaction, and compute vector meson's mass and light-cone wavefunction in the large N limit. Following the same procedure as in the previous analyses for scalar and pseudo-scalar mesons, we derive the bound-state equations of a qq-bar system in the vector channel. We include the lowest order effects of the vector interaction. The resulting transverse and longitudinal components of the bound-state equation look different from each other. But eventually after imposing an appropriate cutoff, one finds these two are identical, giving the same mass and the same (spin-independent) light-cone wavefunction. Mass of the vector meson decreases as one increases the strength of the vector interaction

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: Potential applications to human gene therapy and neuronal physiology

International Nuclear Information System (INIS)

Geller, A.I.; Keyomarsi, K.; Bryan, J.; Pardee, A.B.

1990-01-01

The authors have previously described a defective herpes simplex virus (HSV-1) vector system that permits that introduction of virtually any gene into nonmitotic cells. pHSVlac, the prototype vector, stably expresses Escherichia coli β-galactosidase from a constitutive promoter in many human cell lines, in cultured rat neurons from throughout the nervous system, and in cells in the adult rat brain. HSV-1 vectors expressing other genes may prove useful for studying neuronal physiology or performing human gene therapy for neurological diseases, such as Parkinson disease or brain tumors. A HSV-1 temperature-sensitive (ts) mutant, ts K, has been used as helper virus; ts mutants revert to wild type. In contrast, HSV-1 deletion mutants essentially cannot revert to wild type; therefore, use of a deletion mutant as helper virus might permit human gene therapy with HSV-1 vectors. They now report an efficient packaging system for HSV-1 VECTORS USING A DELETION MUTANT, d30EBA, as helper virus; virus is grown on the complementing cell line M64A. pHSVlac virus prepared using the deletion mutant packaging system stably expresses β-galactosidase in cultured rat sympathetic neurons and glia. Both D30EBA and ts K contain a mutation in the IE3 gene of HSV-1 strain 17 and have the same phenotype; therefore, changing the helper virus from ts K to D30EBA does not alter the host range or other properties of the HSV-1 vector system

Design of a Two-level Adaptive Multi-Agent System for Malaria Vectors driven by an ontology

Directory of Open Access Journals (Sweden)

Etang Josiane

2007-07-01

Full Text Available Abstract Background The understanding of heterogeneities in disease transmission dynamics as far as malaria vectors are concerned is a big challenge. Many studies while tackling this problem don't find exact models to explain the malaria vectors propagation. Methods To solve the problem we define an Adaptive Multi-Agent System (AMAS which has the property to be elastic and is a two-level system as well. This AMAS is a dynamic system where the two levels are linked by an Ontology which allows it to function as a reduced system and as an extended system. In a primary level, the AMAS comprises organization agents and in a secondary level, it is constituted of analysis agents. Its entry point, a User Interface Agent, can reproduce itself because it is given a minimum of background knowledge and it learns appropriate "behavior" from the user in the presence of ambiguous queries and from other agents of the AMAS in other situations. Results Some of the outputs of our system present a series of tables, diagrams showing some factors like Entomological parameters of malaria transmission, Percentages of malaria transmission per malaria vectors, Entomological inoculation rate. Many others parameters can be produced by the system depending on the inputted data. Conclusion Our approach is an intelligent one which differs from statistical approaches that are sometimes used in the field. This intelligent approach aligns itself with the distributed artificial intelligence. In terms of fight against malaria disease our system offers opportunities of reducing efforts of human resources who are not obliged to cover the entire territory while conducting surveys. Secondly the AMAS can determine the presence or the absence of malaria vectors even when specific data have not been collected in the geographical area. In the difference of a statistical technique, in our case the projection of the results in the field can sometimes appeared to be more general.

FUSION DECISION FOR A BIMODAL BIOMETRIC VERIFICATION SYSTEM USING SUPPORT VECTOR MACHINE AND ITS VARIATIONS

Directory of Open Access Journals (Sweden)

A. Teoh

2017-12-01

Full Text Available This paw presents fusion detection technique comparisons based on support vector machine and its variations for a bimodal biometric verification system that makes use of face images and speech utterances. The system is essentially constructed by a face expert, a speech expert and a fusion decision module. Each individual expert has been optimized to operate in automatic mode and designed for security access application. Fusion decision schemes considered are linear, weighted Support Vector Machine (SVM and linear SVM with quadratic transformation. The conditions tested include the balanced and unbalanced conditions between the two experts in order to obtain the optimum fusion module from  these techniques best suited to the target application.

A comparative assessment of battery and fuel cell electric vehicles using a well-to-wheel analysis

International Nuclear Information System (INIS)

Li, Mengyu; Zhang, Xiongwen; Li, Guojun

2016-01-01

Battery electric vehicles (BEVs) and fuel cell electric vehicles (FCEVs) are increasingly prevalent in the transportation sector due to growing concerns about climate change, urban air pollution and oil dependence. This theoretical study reports the results of well-to-wheel (WTW) analyses for BEVs and FCEVs in different energy resource and technology pathways in China in terms of fossil energy use, total energy use and greenhouse gas (GHG) emissions. The energy types include coal, natural gas, renewable energy and nuclear energy resources. Special attention is given to the effects of vehicle heating loads on the WTW performances of BEVs and FCEVs. Energy use and GHG emissions reductions from BEVs and FCEVs in different pathways are examined and compared to those of gasoline-based internal engine vehicles (ICEVs). When considering the cabin heating load in vehicles, FCEVs using natural gas as the energy source outperformed all the BEVs in terms of total energy use and GHG emissions. FCEVs adopting new energy-based pathways can achieve the same WTW efficiencies as BEVs, and these efficiencies may be even higher if the hydrogen used by FCEVs is produced by the pathways of solar-solid oxide electrolysis cell (SOEC) systems, solar-thermochemical systems or nuclear-SOEC systems. - Highlights: • A well-to-wheel analysis is performed for electric vehicle technologies in China. • The effects of cabin heating on well-to-wheel performances are investigated. • The performances of different electric vehicle pathways are presented in detail. • FCEVs with natural gas pathways outperformed BEVs.

The design and implementation of cost-effective algorithms for direct solution of banded linear systems on the vector processor system 32 supercomputer

Science.gov (United States)

Samba, A. S.

1985-01-01

The problem of solving banded linear systems by direct (non-iterative) techniques on the Vector Processor System (VPS) 32 supercomputer is considered. Two efficient direct methods for solving banded linear systems on the VPS 32 are described. The vector cyclic reduction (VCR) algorithm is discussed in detail. The performance of the VCR on a three parameter model problem is also illustrated. The VCR is an adaptation of the conventional point cyclic reduction algorithm. The second direct method is the Customized Reduction of Augmented Triangles' (CRAT). CRAT has the dominant characteristics of an efficient VPS 32 algorithm. CRAT is tailored to the pipeline architecture of the VPS 32 and as a consequence the algorithm is implicitly vectorizable.

Modeling a ground-coupled heat pump system by a support vector machine

Energy Technology Data Exchange (ETDEWEB)

Esen, Hikmet; Esen, Mehmet [Department of Mechanical Education, Faculty of Technical Education, Firat University, 23119 Elazig (Turkey); Inalli, Mustafa [Department of Mechanical Engineering, Faculty of Engineering, Firat University, 23279 Elazig (Turkey); Sengur, Abdulkadir [Department of Electronic and Computer Science, Faculty of Technical Education, Firat University, 23119 Elazig (Turkey)

2008-08-15

This paper reports on a modeling study of ground coupled heat pump (GCHP) system performance (COP) by using a support vector machine (SVM) method. A GCHP system is a multi-variable system that is hard to model by conventional methods. As regards the SVM, it has a superior capability for generalization, and this capability is independent of the dimensionality of the input data. In this study, a SVM based method was intended to adopt GCHP system for efficient modeling. The Lin-kernel SVM method was quite efficient in modeling purposes and did not require a pre-knowledge about the system. The performance of the proposed methodology was evaluated by using several statistical validation parameters. It is found that the root-mean squared (RMS) value is 0.002722, the coefficient of multiple determinations (R{sup 2}) value is 0.999999, coefficient of variation (cov) value is 0.077295, and mean error function (MEF) value is 0.507437 for the proposed Lin-kernel SVM method. The optimum parameters of the SVM method were determined by using a greedy search algorithm. This search algorithm was effective for obtaining the optimum parameters. The simulation results show that the SVM is a good method for prediction of the COP of the GCHP system. The computation of SVM model is faster compared with other machine learning techniques (artificial neural networks (ANN) and adaptive neuro-fuzzy inference system (ANFIS)); because there are fewer free parameters and only support vectors (only a fraction of all data) are used in the generalization process. (author)

Solution of single linear tridiagonal systems and vectorization of the ICCG algorithm on the Cray 1

International Nuclear Information System (INIS)

Kershaw, D.S.

1981-01-01

The numerical algorithms used to solve the physics equation in codes which model laser fusion are examined, it is found that a large number of subroutines require the solution of tridiagonal linear systems of equations. One dimensional radiation transport, thermal and suprathermal electron transport, ion thermal conduction, charged particle and neutron transport, all require the solution of tridiagonal systems of equations. The standard algorithm that has been used in the past on CDC 7600's will not vectorize and so cannot take advantage of the large speed increases possible on the Cray-1 through vectorization. There is however, an alternate algorithm for solving tridiagonal systems, called cyclic reduction, which allows for vectorization, and which is optimal for the Cray-1. Software based on this algorithm is now being used in LASNEX to solve tridiagonal linear systems in the subroutines mentioned above. The new algorithm runs as much as five times faster than the standard algorithm on the Cray-1. The ICCG method is being used to solve the diffusion equation with a nine-point coupling scheme on the CDC 7600. In going from the CDC 7600 to the Cray-1, a large part of the algorithm consists of solving tridiagonal linear systems on each L line of the Lagrangian mesh in a manner which is not vectorizable. An alternate ICCG algorithm for the Cray-1 was developed which utilizes a block form of the cyclic reduction algorithm. This new algorithm allows full vectorization and runs as much as five times faster than the old algorithm on the Cray-1. It is now being used in Cray LASNEX to solve the two-dimensional diffusion equation in all the physics subroutines mentioned above

Design and Modeling of a Novel Torque Vectoring Differential System

Directory of Open Access Journals (Sweden)

Chen Yu-Fan

2017-01-01

Full Text Available In this paper, a new concept torque vectoring differential (TVD system is presented. It is shown that the structure and the mechanism of the system, the operating methods, and the parameters design by a simulation program, i.e. SimulationX. First of all, the structure of the new TVD system is introduced, as well as the relevant mechanic equations. Second, we attempt to verify the feasibility and accuracy of SimulationX through establishing a simple mechanical model by MATLAB, so that the further modeling and simulation results of the new TVD system will be credible. Then, the simulation results at the setting conditions are presented. Finally, the sensitivity of the design parameters is analyzed, including adjusting the braking torque and the dimensions of the gear sets in the differential. According to these results, the characteristics of the new TVD system can be derived in order to develop the whole system with vehicle dynamic model in the next stage.

On the Vectorization of FIR Filterbanks

Directory of Open Access Journals (Sweden)

Barbedo Jayme Garcia Arnal

2007-01-01

Full Text Available This paper presents a vectorization technique to implement FIR filterbanks. The word vectorization, in the context of this work, refers to a strategy in which all iterative operations are replaced by equivalent vector and matrix operations. This approach allows that the increasing parallelism of the most recent computer processors and systems be properly explored. The vectorization techniques are applied to two kinds of FIR filterbanks (conventional and recursi ve, and are presented in such a way that they can be easily extended to any kind of FIR filterbanks. The vectorization approach is compared to other kinds of implementation that do not explore the parallelism, and also to a previous FIR filter vectorization approach. The tests were performed in Matlab and , in order to explore different aspects of the proposed technique.

On the Vectorization of FIR Filterbanks

Directory of Open Access Journals (Sweden)

Amauri Lopes

2007-01-01

Full Text Available This paper presents a vectorization technique to implement FIR filterbanks. The word vectorization, in the context of this work, refers to a strategy in which all iterative operations are replaced by equivalent vector and matrix operations. This approach allows that the increasing parallelism of the most recent computer processors and systems be properly explored. The vectorization techniques are applied to two kinds of FIR filterbanks (conventional and recursi ve, and are presented in such a way that they can be easily extended to any kind of FIR filterbanks. The vectorization approach is compared to other kinds of implementation that do not explore the parallelism, and also to a previous FIR filter vectorization approach. The tests were performed in Matlab and C, in order to explore different aspects of the proposed technique.

Parameter identification based synchronization for a class of chaotic systems with offset vectors

International Nuclear Information System (INIS)

Chen Cailian; Feng Gang; Guan Xinping

2004-01-01

Based on a parameter identification scheme, a novel synchronization method is presented for a class of chaotic systems with offset vectors which can be represented by the so-called T-S fuzzy model. It is shown that the slave system can synchronize the master system and the unknown parameters of the master system can be identified simultaneously. The delayed feedback technique is also developed in order to reduce the energy and time required for the identification and synchronization. Numerical simulations demonstrate the effectiveness of the proposed method

Problems and worked solutions in vector analysis

CERN Document Server

Shorter, LR

2014-01-01

""A handy book like this,"" noted The Mathematical Gazette, ""will fill a great want."" Devoted to fully worked out examples, this unique text constitutes a self-contained introductory course in vector analysis for undergraduate and graduate students of applied mathematics.Opening chapters define vector addition and subtraction, show how to resolve and determine the direction of two or more vectors, and explain systems of coordinates, vector equations of a plane and straight line, relative velocity and acceleration, and infinitely small vectors. The following chapters deal with scalar and vect

Cosmological evolution in vector-tensor theories of gravity

International Nuclear Information System (INIS)

Beltran Jimenez, Jose; Maroto, Antonio L.

2009-01-01

We present a detailed study of the cosmological evolution in general vector-tensor theories of gravity without potential terms. We consider the evolution of the vector field throughout the expansion history of the Universe and carry out a classification of models according to the behavior of the vector field in each cosmological epoch. We also analyze the case in which the Universe is dominated by the vector field, performing a complete analysis of the system phase map and identifying those attracting solutions which give rise to accelerated expansion. Moreover, we consider the evolution in a universe filled with a pressureless fluid in addition to the vector field and study the existence of attractors in which we can have a transition from matter domination to vector domination with accelerated expansion so that the vector field may play the role of dark energy. We find that the existence of solutions with late-time accelerated expansion is a generic prediction of vector-tensor theories and that such solutions typically lead to the presence of future singularities. Finally, limits from local gravity tests are used to get constraints on the value of the vector field at small (Solar System) scales.

A program system for ab initio MO calculations on vector and parallel processing machines. Pt. 1

International Nuclear Information System (INIS)

Ernenwein, R.; Rohmer, M.M.; Benard, M.

1990-01-01

We present a program system for ab initio molecular orbital calculations on vector and parallel computers. The present article is devoted to the computation of one- and two-electron integrals over contracted Gaussian basis sets involving s-, p-, d- and f-type functions. The McMurchie and Davidson (MMD) algorithm has been implemented and parallelized by distributing over a limited number of logical tasks the calculation of the 55 relevant classes of integrals. All sections of the MMD algorithm have been efficiently vectorized, leading to a scalar/vector ratio of 5.8. Different algorithms are proposed and compared for an optimal vectorization of the contraction of the 'intermediate integrals' generated by the MMD formalism. Advantage is taken of the dynamic storage allocation for tuning the length of the vector loops (i.e. the size of the vectorization buffer) as a function of (i) the total memory available for the job, (ii) the number of logical tasks defined by the user (≤13), and (iii) the storage requested by each specific class of integrals. Test calculations carried out on a CRAY-2 computer show that the average number of finite integrals computed over a (s, p, d, f) CGTO basis set is about 1180000 per second and per processor. The combination of vectorization and parallelism on this 4-processor machine reduces the CPU time by a factor larger than 20 with respect to the scalar and sequential performance. (orig.)

Problems of vector Lagrangians in field theories

International Nuclear Information System (INIS)

Krivsky, I.Yu.; Simulik, V.M.

1997-01-01

A vector Lagrange approach to the Dirac spinor field and the relationship between the vector Lagrangians for the spinor and electromagnetic fields are considered. A vector Lagrange approach for the system of interacting electromagnetic B=(B μ υ)=(E-bar,H-bar) and spinor Ψ fields is constructed. New Lagrangians (scalar and vector) for electromagnetic field in terms of field strengths are found. The foundations of two new QED models are formulated

VectorH : Taking SQL-on-Hadoop to the next level

NARCIS (Netherlands)

Costea, Andrei; Ionescu, Adrian; Raducanu, Bogdan; Świtakowski, Michał; Bârca, Cristian; Sompolski, Juliusz; Łuszczak, Alicja; Szafrański, Michał; De Nijs, Giel; Boncz, Peter

2016-01-01

Actian Vector in Hadoop (VectorH for short) is a new SQL-on-Hadoop system built on top of the fast Vectorwise analytical database system. VectorH achieves fault tolerance and storage scalability by relying on HDFS, and extends the state-of-the-art in SQL-on-Hadoop systems by instrumenting the HDFS

Isomorphism Theorem on Vector Spaces over a Ring

Directory of Open Access Journals (Sweden)

Futa Yuichi

2017-10-01

Full Text Available In this article, we formalize in the Mizar system [1, 4] some properties of vector spaces over a ring. We formally prove the first isomorphism theorem of vector spaces over a ring. We also formalize the product space of vector spaces. ℤ-modules are useful for lattice problems such as LLL (Lenstra, Lenstra and Lovász [5] base reduction algorithm and cryptographic systems [6, 2].

Vectorization, parallelization and porting of nuclear codes on the VPP500 system (parallelization). Progress report fiscal 1996

Energy Technology Data Exchange (ETDEWEB)

Watanabe, Hideo; Kawai, Wataru; Nemoto, Toshiyuki [Fujitsu Ltd., Tokyo (Japan); and others

1997-12-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the parallelization. In this parallelization part, the parallelization of 2-Dimensional relativistic electromagnetic particle code EM2D, Cylindrical Direct Numerical Simulation code CYLDNS and molecular dynamics code for simulating radiation damages in diamond crystals DGR are described. In the vectorization part, the vectorization of two and three dimensional discrete ordinates simulation code DORT-TORT, gas dynamics analysis code FLOWGR and relativistic Boltzmann-Uehling-Uhlenbeck simulation code RBUU are described. And then, in the porting part, the porting of reactor safety analysis code RELAP5/MOD3.2 and RELAP5/MOD3.2.1.2, nuclear data processing system NJOY and 2-D multigroup discrete ordinate transport code TWOTRAN-II are described. And also, a survey for the porting of command-driven interactive data analysis plotting program IPLOT are described. (author)

Vectorization, parallelization and porting of nuclear codes on the VPP500 system (porting). Progress report fiscal 1996

Energy Technology Data Exchange (ETDEWEB)

Nemoto, Toshiyuki [Fujitsu Ltd., Tokyo (Japan); Kawasaki, Nobuo; Tanabe, Hidenobu [and others

1998-01-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. These results are reported in 3 parts, i.e., the vectorization part, the parallelization part and the porting part. In this report, we describe the porting. In this porting part, the porting of reactor safety analysis code RELAP5/MOD3.2 and RELAP5/MOD3.2.1.2, nuclear data processing system NJOY and 2-D multigroup discrete ordinate transport code TWOTRAN-II are described. And also, a survey for the porting of command-driven interactive data analysis plotting program IPLOT are described. In the parallelization part, the parallelization of 2-Dimensional relativistic electromagnetic particle code EM2D, Cylindrical Direct Numerical Simulation code CYLDNS and molecular dynamics code for simulating radiation damages in diamond crystals DGR are described. And then, in the vectorization part, the vectorization of two and three dimensional discrete ordinates simulation code DORT-TORT, gas dynamics analysis code FLOWGR and relativistic Boltzmann-Uehling-Uhlenbeck simulation code RBUU are described. (author)

Performance monitoring for coherent DP-QPSK systems based on stokes vectors analysis

Science.gov (United States)

Louchet, Hadrien; Koltchanov, Igor; Richter, André

2010-12-01

We show how to estimate accurately the Jones matrix of the transmission line by analyzing the Stokes vectors of DP-QPSK signals. This method can be used to perform in-situ PMD measurement in dual-polarization QPSK systems, and in addition to the constant modulus algorithm (CMA) to mitigate polarization-induced impairments. The applicability of this method to other modulation formats is discussed.

Which Factors Can Protect Against Range Stress in Everyday Usage of Battery Electric Vehicles? Toward Enhancing Sustainability of Electric Mobility Systems.

Science.gov (United States)

Franke, Thomas; Rauh, Nadine; Günther, Madlen; Trantow, Maria; Krems, Josef F

2016-02-01

The objective of the present research was to advance understanding of factors that can protect against range anxiety, specifically range stress in everyday usage of battery electric vehicles (BEVs). Range anxiety is a major barrier to the broad adoption of sustainable electric mobility systems. To develop strategies aimed at overcoming range anxiety, a clear understanding of this phenomenon and influencing factors is needed. We examined range anxiety in the form of everyday range stress (ERS) in a field study setting. Seventy-two customers leased a BEV for 3 months. The field study was specifically designed to enable examination of factors that can contribute to lower ERS. In particular, study design and sample recruitment were targeted at generating vehicle usage profiles that would lead to relatively frequent experience of situations requiring active management of range resources and thereby potentially leading to experienced range stress. Less frequent encounter with critical range situations, higher practical experience, subjective range competence, tolerance of low range, and experienced trustworthiness of the range estimation system were related to lower ERS. Moreover, range stress was found to be related to range satisfaction and BEV acceptance. The results underline the importance of the human factors perspective to overcome range anxiety and enhance sustainability of electric mobility systems. Trustworthiness should be employed as a key benchmark variable in the design of range estimation systems, and assistance systems should target increasing drivers' adaptive capacity (i.e., resilience) to cope with critical range situations. © 2015, Human Factors and Ergonomics Society.

Back-to-back three-level converter controlled by a novel space-vector hysteresis current control for wind conversion systems

Energy Technology Data Exchange (ETDEWEB)

Ghennam, Tarak [Laboratoire d' Electronique de Puissance (LEP), UER: Electrotechnique, Ecole Militaire Polytechnique d' Alger, BP 17, Bordj EL Bahri, Alger (Algeria); Berkouk, El-Madjid [Laboratoire de Commande des Processus (LCP), Ecole Nationale Polytechnique d' Alger, BP 182, 10 avenue Hassen Badi, 16200 el Harrach (Algeria)

2010-04-15

In this paper, a novel space-vector hysteresis current control (SVHCC) is proposed for a back-to-back three-level converter which is used as an electronic interface in a wind conversion system. The proposed SVHCC controls the active and reactive powers delivered to the grid by the doubly fed induction machine (DFIM) through the control of its rotor currents. In addition, it controls the neutral point voltage by using the redundant inverter switching states. The three rotor current errors are gathered into a single space-vector quantity. The magnitude of the error vector is limited within boundary areas of a square shape. The control scheme is based firstly on the detection of the area and sector in which the vector tip of the current error can be located. Then, an appropriate voltage vector among the 27 voltage vectors of the three-level voltage source inverter (VSI) is applied to push the error vector towards the hysteresis boundaries. Simple look-up tables are required for the area and sector detection, and also for vector selection. The performance of the proposed control technique has been verified by simulations. (author)

Comparative analysis of battery electric, hydrogen fuel cell and hybrid vehicles in a future sustainable road transport system

Energy Technology Data Exchange (ETDEWEB)

Offer, G.J.; Brandon, N.P. [Department Earth Science Engineering, Imperial College London, SW7 2AZ (United Kingdom); Howey, D. [Department of Electrical and Electronic Engineering, Imperial College London, SW7 2AZ (United Kingdom); Contestabile, M. [Centre for Environmental Policy, Imperial College London, SW7 2AZ (United Kingdom); Clague, R. [Energy Futures Lab, Imperial College London, SW7 2AZ (United Kingdom)

2010-01-15

This paper compares battery electric vehicles (BEV) to hydrogen fuel cell electric vehicles (FCEV) and hydrogen fuel cell plug-in hybrid vehicles (FCHEV). Qualitative comparisons of technologies and infrastructural requirements, and quantitative comparisons of the lifecycle cost of the powertrain over 100,000 mile are undertaken, accounting for capital and fuel costs. A common vehicle platform is assumed. The 2030 scenario is discussed and compared to a conventional gasoline-fuelled internal combustion engine (ICE) powertrain. A comprehensive sensitivity analysis shows that in 2030 FCEVs could achieve lifecycle cost parity with conventional gasoline vehicles. However, both the BEV and FCHEV have significantly lower lifecycle costs. In the 2030 scenario, powertrain lifecycle costs of FCEVs range from $7360 to $22,580, whereas those for BEVs range from $6460 to $11,420 and FCHEVs, from $4310 to $12,540. All vehicle platforms exhibit significant cost sensitivity to powertrain capital cost. The BEV and FCHEV are relatively insensitive to electricity costs but the FCHEV and FCV are sensitive to hydrogen cost. The BEV and FCHEV are reasonably similar in lifecycle cost and one may offer an advantage over the other depending on driving patterns. A key conclusion is that the best path for future development of FCEVs is the FCHEV. (author)

Comparative analysis of battery electric, hydrogen fuel cell and hybrid vehicles in a future sustainable road transport system

International Nuclear Information System (INIS)

Offer, G.J.; Howey, D.; Contestabile, M.; Clague, R.; Brandon, N.P.

2010-01-01

This paper compares battery electric vehicles (BEV) to hydrogen fuel cell electric vehicles (FCEV) and hydrogen fuel cell plug-in hybrid vehicles (FCHEV). Qualitative comparisons of technologies and infrastructural requirements, and quantitative comparisons of the lifecycle cost of the powertrain over 100,000 mile are undertaken, accounting for capital and fuel costs. A common vehicle platform is assumed. The 2030 scenario is discussed and compared to a conventional gasoline-fuelled internal combustion engine (ICE) powertrain. A comprehensive sensitivity analysis shows that in 2030 FCEVs could achieve lifecycle cost parity with conventional gasoline vehicles. However, both the BEV and FCHEV have significantly lower lifecycle costs. In the 2030 scenario, powertrain lifecycle costs of FCEVs range from $7360 to $22,580, whereas those for BEVs range from $6460 to $11,420 and FCHEVs, from $4310 to $12,540. All vehicle platforms exhibit significant cost sensitivity to powertrain capital cost. The BEV and FCHEV are relatively insensitive to electricity costs but the FCHEV and FCV are sensitive to hydrogen cost. The BEV and FCHEV are reasonably similar in lifecycle cost and one may offer an advantage over the other depending on driving patterns. A key conclusion is that the best path for future development of FCEVs is the FCHEV.

Space vector modulation strategy for neutral-point voltage balancing in three-level inverter systems

DEFF Research Database (Denmark)

Choi, Uimin; Lee, Kyo Beum

2013-01-01

This study proposes a space vector modulation (SVM) strategy to balance the neutral-point voltage of three-level inverter systems. The proposed method is implemented by combining conventional symmetric SVM with nearest three-vector (NTV) modulation. The conventional SVM is converted to NTV...... modulation by properly adding or subtracting a minimum gate-on time. In addition, using this method, the switching frequency is reduced and a decrease of switching loss would be yielded. The neutral-point voltage is balanced by the proposed SVM strategy without additional hardware or complex calculations....... Simulation and experimental results are shown to verify the validity and feasibility of the proposed SVM strategy....

Environmental management: a re-emerging vector control strategy.

Science.gov (United States)

Ault, S K

1994-01-01

Vector control may be accomplished by environmental management (EM), which consists of permanent or long-term modification of the environment, temporary or seasonal manipulation of the environment, and modifying or changing our life styles and practices to reduce human contact with infective vectors. The primary focus of this paper is EM in the control of human malaria, filariasis, arboviruses, Chagas' disease, and schistosomiasis. Modern EM developed as a discipline based primarily in ecologic principles and lessons learned from the adverse environmental impacts of rural development projects. Strategies such as the suppression of vector populations through the provision of safe water supplies, proper sanitation, solid waste management facilities, sewerage and excreta disposal systems, water manipulation in dams and irrigation systems, vector diversion by zooprophylaxis, and vector exclusion by improved housing, are discussed with appropriate examples. Vectors of malaria, filariasis, Chagas' disease, and schistosomiasis have been controlled by drainage or filling aquatic breeding sites, improved housing and sanitation, the use of expanded polystyrene beads, zooprophylaxis, or the provision of household water supplies. Community participation has been effective in the suppression of dengue vectors in Mexico and the Dominican Republic. Alone or combined with other vector control methods, EM has been proven to be a successful approach to vector control in a number of places. The future of EM in vector control looks promising.

Anticipatory Monitoring and Control of Complex Systems using a Fuzzy based Fusion of Support Vector Regressors

Energy Technology Data Exchange (ETDEWEB)

Miltiadis Alamaniotis; Vivek Agarwal

2014-10-01

This paper places itself in the realm of anticipatory systems and envisions monitoring and control methods being capable of making predictions over system critical parameters. Anticipatory systems allow intelligent control of complex systems by predicting their future state. In the current work, an intelligent model aimed at implementing anticipatory monitoring and control in energy industry is presented and tested. More particularly, a set of support vector regressors (SVRs) are trained using both historical and observed data. The trained SVRs are used to predict the future value of the system based on current operational system parameter. The predicted values are then inputted to a fuzzy logic based module where the values are fused to obtain a single value, i.e., final system output prediction. The methodology is tested on real turbine degradation datasets. The outcome of the approach presented in this paper highlights the superiority over single support vector regressors. In addition, it is shown that appropriate selection of fuzzy sets and fuzzy rules plays an important role in improving system performance.

Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases.

Directory of Open Access Journals (Sweden)

Kenichi W Okamoto

2016-03-01

Full Text Available Many vector-borne diseases lack effective vaccines and medications, and the limitations of traditional vector control have inspired novel approaches based on using genetic engineering to manipulate vector populations and thereby reduce transmission. Yet both the short- and long-term epidemiological effects of these transgenic strategies are highly uncertain. If neither vaccines, medications, nor transgenic strategies can by themselves suffice for managing vector-borne diseases, integrating these approaches becomes key. Here we develop a framework to evaluate how clinical interventions (i.e., vaccination and medication can be integrated with transgenic vector manipulation strategies to prevent disease invasion and reduce disease incidence. We show that the ability of clinical interventions to accelerate disease suppression can depend on the nature of the transgenic manipulation deployed (e.g., whether vector population reduction or replacement is attempted. We find that making a specific, individual strategy highly effective may not be necessary for attaining public-health objectives, provided suitable combinations can be adopted. However, we show how combining only partially effective antimicrobial drugs or vaccination with transgenic vector manipulations that merely temporarily lower vector competence can amplify disease resurgence following transient suppression. Thus, transgenic vector manipulation that cannot be sustained can have adverse consequences-consequences which ineffective clinical interventions can at best only mitigate, and at worst temporarily exacerbate. This result, which arises from differences between the time scale on which the interventions affect disease dynamics and the time scale of host population dynamics, highlights the importance of accounting for the potential delay in the effects of deploying public health strategies on long-term disease incidence. We find that for systems at the disease-endemic equilibrium, even

Emerging Vector-Borne Diseases - Incidence through Vectors.

Science.gov (United States)

Savić, Sara; Vidić, Branka; Grgić, Zivoslav; Potkonjak, Aleksandar; Spasojevic, Ljubica

2014-01-01

Vector-borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowadays, in intercontinental countries, there is a struggle with emerging diseases, which have found their way to appear through vectors. Vector-borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens, and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector-borne infectious diseases and disease outbreaks. It could affect the range and population of pathogens, host and vectors, transmission season, etc. Reliable surveillance for diseases that are most likely to emerge is required. Canine vector-borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, ehrlichiosis, and leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fundamental role at primarily prevention and then treatment of vector-borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases. During a 4-year period, from 2009 to 2013, a total number of 551 dog samples were analyzed for vector-borne diseases (borreliosis, babesiosis, ehrlichiosis, anaplasmosis, dirofilariosis, and leishmaniasis) in routine laboratory work. The analysis was done by serological tests - ELISA for borreliosis, dirofilariosis, and leishmaniasis, modified Knott test for dirofilariosis, and blood smear for babesiosis, ehrlichiosis, and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on average more then half of the samples

Viral vector-based influenza vaccines

Science.gov (United States)

de Vries, Rory D.; Rimmelzwaan, Guus F.

2016-01-01

ABSTRACT Antigenic drift of seasonal influenza viruses and the occasional introduction of influenza viruses of novel subtypes into the human population complicate the timely production of effective vaccines that antigenically match the virus strains that cause epidemic or pandemic outbreaks. The development of game-changing vaccines that induce broadly protective immunity against a wide variety of influenza viruses is an unmet need, in which recombinant viral vectors may provide. Use of viral vectors allows the delivery of any influenza virus antigen, or derivative thereof, to the immune system, resulting in the optimal induction of virus-specific B- and T-cell responses against this antigen of choice. This systematic review discusses results obtained with vectored influenza virus vaccines and advantages and disadvantages of the currently available viral vectors. PMID:27455345

Vector analysis

CERN Document Server

Newell, Homer E

2006-01-01

When employed with skill and understanding, vector analysis can be a practical and powerful tool. This text develops the algebra and calculus of vectors in a manner useful to physicists and engineers. Numerous exercises (with answers) not only provide practice in manipulation but also help establish students' physical and geometric intuition in regard to vectors and vector concepts.Part I, the basic portion of the text, consists of a thorough treatment of vector algebra and the vector calculus. Part II presents the illustrative matter, demonstrating applications to kinematics, mechanics, and e

Single vector system for efficient N-myristoylation of recombinant proteins in E. coli.

Directory of Open Access Journals (Sweden)

Julian M Glück

Full Text Available BACKGROUND: N-myristoylation is a crucial covalent modification of numerous eukaryotic and viral proteins that is catalyzed by N-myristoyltransferase (NMT. Prokaryotes are lacking endogenous NMT activity. Recombinant production of N-myristoylated proteins in E. coli cells can be achieved by coexpression of heterologous NMT with the target protein. In the past, dual plasmid systems were used for this purpose. METHODOLOGY/PRINCIPAL FINDINGS: Here we describe a single vector system for efficient coexpression of substrate and enzyme suitable for production of co- or posttranslationally modified proteins. The approach was validated using the HIV-1 Nef protein as an example. A simple and efficient protocol for production of highly pure and completely N-myristoylated Nef is presented. The yield is about 20 mg myristoylated Nef per liter growth medium. CONCLUSIONS/SIGNIFICANCE: The single vector strategy allows diverse modifications of target proteins recombinantly coexpressed in E. coli with heterologous enzymes. The method is generally applicable and provides large amounts of quantitatively processed target protein that are sufficient for comprehensive biophysical and structural studies.

Thru-life impacts of driver aggression, climate, cabin thermal management, and battery thermal management on battery electric vehicle utility

Science.gov (United States)

Neubauer, Jeremy; Wood, Eric

2014-08-01

Battery electric vehicles (BEVs) offer the potential to reduce both oil imports and greenhouse gas emissions, but have a limited utility that is affected by driver aggression and effects of climate-both directly on battery temperature and indirectly through the loads of cabin and battery thermal management systems. Utility is further affected as the battery wears through life in response to travel patterns, climate, and other factors. In this paper we apply the National Renewable Energy Laboratory's Battery Lifetime Analysis and Simulation Tool for Vehicles (BLAST-V) to examine the sensitivity of BEV utility to driver aggression and climate effects over the life of the vehicle. We find the primary challenge to cold-climate BEV operation to be inefficient cabin heating systems, and to hot-climate BEV operation to be high peak on-road battery temperatures and excessive battery degradation. Active cooling systems appear necessary to manage peak battery temperatures of aggressive, hot-climate drivers, which can then be employed to maximize thru-life vehicle utility.

Vector-Tensor and Vector-Vector Decay Amplitude Analysis of B0→φK*0

International Nuclear Information System (INIS)

Aubert, B.; Bona, M.; Boutigny, D.; Couderc, F.; Karyotakis, Y.; Lees, J. P.; Poireau, V.; Tisserand, V.; Zghiche, A.; Grauges, E.; Palano, A.; Chen, J. C.; Qi, N. D.; Rong, G.; Wang, P.; Zhu, Y. S.; Eigen, G.; Ofte, I.; Stugu, B.; Abrams, G. S.

2007-01-01

We perform an amplitude analysis of the decays B 0 →φK 2 * (1430) 0 , φK * (892) 0 , and φ(Kπ) S-wave 0 with a sample of about 384x10 6 BB pairs recorded with the BABAR detector. The fractions of longitudinal polarization f L of the vector-tensor and vector-vector decay modes are measured to be 0.853 -0.069 +0.061 ±0.036 and 0.506±0.040±0.015, respectively. Overall, twelve parameters are measured for the vector-vector decay and seven parameters for the vector-tensor decay, including the branching fractions and parameters sensitive to CP violation

About vectors

CERN Document Server

Hoffmann, Banesh

1975-01-01

From his unusual beginning in ""Defining a vector"" to his final comments on ""What then is a vector?"" author Banesh Hoffmann has written a book that is provocative and unconventional. In his emphasis on the unresolved issue of defining a vector, Hoffmann mixes pure and applied mathematics without using calculus. The result is a treatment that can serve as a supplement and corrective to textbooks, as well as collateral reading in all courses that deal with vectors. Major topics include vectors and the parallelogram law; algebraic notation and basic ideas; vector algebra; scalars and scalar p

Object Recognition System-on-Chip Using the Support Vector Machines

Directory of Open Access Journals (Sweden)

Houzet Dominique

2005-01-01

Full Text Available The first aim of this work is to propose the design of a system-on-chip (SoC platform dedicated to digital image and signal processing, which is tuned to implement efficiently multiply-and-accumulate (MAC vector/matrix operations. The second aim of this work is to implement a recent promising neural network method, namely, the support vector machine (SVM used for real-time object recognition, in order to build a vision machine. With such a reconfigurable and programmable SoC platform, it is possible to implement any SVM function dedicated to any object recognition problem. The final aim is to obtain an automatic reconfiguration of the SoC platform, based on the results of the learning phase on an objects' database, which makes it possible to recognize practically any object without manual programming. Recognition can be of any kind that is from image to signal data. Such a system is a general-purpose automatic classifier. Many applications can be considered as a classification problem, but are usually treated specifically in order to optimize the cost of the implemented solution. The cost of our approach is more important than a dedicated one, but in a near future, hundreds of millions of gates will be common and affordable compared to the design cost. What we are proposing here is a general-purpose classification neural network implemented on a reconfigurable SoC platform. The first version presented here is limited in size and thus in object recognition performances, but can be easily upgraded according to technology improvements.

Adenoviral vector immunity: its implications and circumvention strategies.

Science.gov (United States)

Ahi, Yadvinder S; Bangari, Dinesh S; Mittal, Suresh K

2011-08-01

Adenoviral (Ad) vectors have emerged as a promising gene delivery platform for a variety of therapeutic and vaccine purposes during last two decades. However, the presence of preexisting Ad immunity and the rapid development of Ad vector immunity still pose significant challenges to the clinical use of these vectors. Innate inflammatory response following Ad vector administration may lead to systemic toxicity, drastically limit vector transduction efficiency and significantly abbreviate the duration of transgene expression. Currently, a number of approaches are being extensively pursued to overcome these drawbacks by strategies that target either the host or the Ad vector. In addition, significant progress has been made in the development of novel Ad vectors based on less prevalent human Ad serotypes and nonhuman Ad. This review provides an update on our current understanding of immune responses to Ad vectors and delineates various approaches for eluding Ad vector immunity. Approaches targeting the host and those targeting the vector are discussed in light of their promises and limitations.

Upport vector machines for nonlinear kernel ARMA system identification.

Science.gov (United States)

Martínez-Ramón, Manel; Rojo-Alvarez, José Luis; Camps-Valls, Gustavo; Muñioz-Marí, Jordi; Navia-Vázquez, Angel; Soria-Olivas, Emilio; Figueiras-Vidal, Aníbal R

2006-11-01

Nonlinear system identification based on support vector machines (SVM) has been usually addressed by means of the standard SVM regression (SVR), which can be seen as an implicit nonlinear autoregressive and moving average (ARMA) model in some reproducing kernel Hilbert space (RKHS). The proposal of this letter is twofold. First, the explicit consideration of an ARMA model in an RKHS (SVM-ARMA2K) is proposed. We show that stating the ARMA equations in an RKHS leads to solving the regularized normal equations in that RKHS, in terms of the autocorrelation and cross correlation of the (nonlinearly) transformed input and output discrete time processes. Second, a general class of SVM-based system identification nonlinear models is presented, based on the use of composite Mercer's kernels. This general class can improve model flexibility by emphasizing the input-output cross information (SVM-ARMA4K), which leads to straightforward and natural combinations of implicit and explicit ARMA models (SVR-ARMA2K and SVR-ARMA4K). Capabilities of these different SVM-based system identification schemes are illustrated with two benchmark problems.

Vectors

DEFF Research Database (Denmark)

Boeriis, Morten; van Leeuwen, Theo

2017-01-01

should be taken into account in discussing ‘reactions’, which Kress and van Leeuwen link only to eyeline vectors. Finally, the question can be raised as to whether actions are always realized by vectors. Drawing on a re-reading of Rudolf Arnheim’s account of vectors, these issues are outlined......This article revisits the concept of vectors, which, in Kress and van Leeuwen’s Reading Images (2006), plays a crucial role in distinguishing between ‘narrative’, action-oriented processes and ‘conceptual’, state-oriented processes. The use of this concept in image analysis has usually focused...

Vector regression introduced

Directory of Open Access Journals (Sweden)

Mok Tik

2014-06-01

Full Text Available This study formulates regression of vector data that will enable statistical analysis of various geodetic phenomena such as, polar motion, ocean currents, typhoon/hurricane tracking, crustal deformations, and precursory earthquake signals. The observed vector variable of an event (dependent vector variable is expressed as a function of a number of hypothesized phenomena realized also as vector variables (independent vector variables and/or scalar variables that are likely to impact the dependent vector variable. The proposed representation has the unique property of solving the coefficients of independent vector variables (explanatory variables also as vectors, hence it supersedes multivariate multiple regression models, in which the unknown coefficients are scalar quantities. For the solution, complex numbers are used to rep- resent vector information, and the method of least squares is deployed to estimate the vector model parameters after transforming the complex vector regression model into a real vector regression model through isomorphism. Various operational statistics for testing the predictive significance of the estimated vector parameter coefficients are also derived. A simple numerical example demonstrates the use of the proposed vector regression analysis in modeling typhoon paths.

Mapping of courses on vector biology and vector-borne diseases systems: time for a worldwide effort

Science.gov (United States)

Casas, Jérôme; Lazzari, Claudio; Insausti, Teresita; Launois, Pascal; Fouque, Florence

2016-01-01

Major emergency efforts are being mounted for each vector-borne disease epidemiological crisis anew, while knowledge about the biology of arthropods vectors is dwindling slowly but continuously, as is the number of field entomologists. The discrepancy between the rates of production of knowledge and its use and need for solving crises is widening, in particular due to the highly differing time spans of the two concurrent processes. A worldwide web based search using multiple key words and search engines of onsite and online courses in English, Spanish, Portuguese, French, Italian and German concerned with the biology of vectors identified over 140 courses. They are geographically and thematically scattered, the vast majority of them are on-site, with very few courses using the latest massive open online course (MOOC) powerfulness. Over two third of them is given in English and Western Africa is particularity poorly represented. The taxonomic groups covered are highly unbalanced towards mosquitoes. A worldwide unique portal to guide students of all grades and levels of expertise, in particular those in remote locations, is badly needed. This is the objective a new activity supported by the Special Programme for Research and Training in Tropical Diseases (TDR). PMID:27759770

Design of 2D time-varying vector fields.

Science.gov (United States)

Chen, Guoning; Kwatra, Vivek; Wei, Li-Yi; Hansen, Charles D; Zhang, Eugene

2012-10-01

Design of time-varying vector fields, i.e., vector fields that can change over time, has a wide variety of important applications in computer graphics. Existing vector field design techniques do not address time-varying vector fields. In this paper, we present a framework for the design of time-varying vector fields, both for planar domains as well as manifold surfaces. Our system supports the creation and modification of various time-varying vector fields with desired spatial and temporal characteristics through several design metaphors, including streamlines, pathlines, singularity paths, and bifurcations. These design metaphors are integrated into an element-based design to generate the time-varying vector fields via a sequence of basis field summations or spatial constrained optimizations at the sampled times. The key-frame design and field deformation are also introduced to support other user design scenarios. Accordingly, a spatial-temporal constrained optimization and the time-varying transformation are employed to generate the desired fields for these two design scenarios, respectively. We apply the time-varying vector fields generated using our design system to a number of important computer graphics applications that require controllable dynamic effects, such as evolving surface appearance, dynamic scene design, steerable crowd movement, and painterly animation. Many of these are difficult or impossible to achieve via prior simulation-based methods. In these applications, the time-varying vector fields have been applied as either orientation fields or advection fields to control the instantaneous appearance or evolving trajectories of the dynamic effects.

A vector-product information retrieval system adapted to heterogeneous, distributed computing environments

Science.gov (United States)

Rorvig, Mark E.

1991-01-01

Vector-product information retrieval (IR) systems produce retrieval results superior to all other searching methods but presently have no commercial implementations beyond the personal computer environment. The NASA Electronic Library Systems (NELS) provides a ranked list of the most likely relevant objects in collections in response to a natural language query. Additionally, the system is constructed using standards and tools (Unix, X-Windows, Notif, and TCP/IP) that permit its operation in organizations that possess many different hosts, workstations, and platforms. There are no known commercial equivalents to this product at this time. The product has applications in all corporate management environments, particularly those that are information intensive, such as finance, manufacturing, biotechnology, and research and development.

Multiscale benchmarking of drug delivery vectors.

Science.gov (United States)

Summers, Huw D; Ware, Matthew J; Majithia, Ravish; Meissner, Kenith E; Godin, Biana; Rees, Paul

2016-10-01

Cross-system comparisons of drug delivery vectors are essential to ensure optimal design. An in-vitro experimental protocol is presented that separates the role of the delivery vector from that of its cargo in determining the cell response, thus allowing quantitative comparison of different systems. The technique is validated through benchmarking of the dose-response of human fibroblast cells exposed to the cationic molecule, polyethylene imine (PEI); delivered as a free molecule and as a cargo on the surface of CdSe nanoparticles and Silica microparticles. The exposure metrics are converted to a delivered dose with the transport properties of the different scale systems characterized by a delivery time, τ. The benchmarking highlights an agglomeration of the free PEI molecules into micron sized clusters and identifies the metric determining cell death as the total number of PEI molecules presented to cells, determined by the delivery vector dose and the surface density of the cargo. Copyright © 2016 Elsevier Inc. All rights reserved.

Elementary vectors

CERN Document Server

Wolstenholme, E Œ

1978-01-01

Elementary Vectors, Third Edition serves as an introductory course in vector analysis and is intended to present the theoretical and application aspects of vectors. The book covers topics that rigorously explain and provide definitions, principles, equations, and methods in vector analysis. Applications of vector methods to simple kinematical and dynamical problems; central forces and orbits; and solutions to geometrical problems are discussed as well. This edition of the text also provides an appendix, intended for students, which the author hopes to bridge the gap between theory and appl

An episomal vector-based CRISPR/Cas9 system for highly efficient gene knockout in human pluripotent stem cells.

Science.gov (United States)

Xie, Yifang; Wang, Daqi; Lan, Feng; Wei, Gang; Ni, Ting; Chai, Renjie; Liu, Dong; Hu, Shijun; Li, Mingqing; Li, Dajin; Wang, Hongyan; Wang, Yongming

2017-05-24

Human pluripotent stem cells (hPSCs) represent a unique opportunity for understanding the molecular mechanisms underlying complex traits and diseases. CRISPR/Cas9 is a powerful tool to introduce genetic mutations into the hPSCs for loss-of-function studies. Here, we developed an episomal vector-based CRISPR/Cas9 system, which we called epiCRISPR, for highly efficient gene knockout in hPSCs. The epiCRISPR system enables generation of up to 100% Insertion/Deletion (indel) rates. In addition, the epiCRISPR system enables efficient double-gene knockout and genomic deletion. To minimize off-target cleavage, we combined the episomal vector technology with double-nicking strategy and recent developed high fidelity Cas9. Thus the epiCRISPR system offers a highly efficient platform for genetic analysis in hPSCs.

A concurrent visualization system for large-scale unsteady simulations. Parallel vector performance on an NEC SX-4

International Nuclear Information System (INIS)

Takei, Toshifumi; Doi, Shun; Matsumoto, Hideki; Muramatsu, Kazuhiro

2000-01-01

We have developed a concurrent visualization system RVSLIB (Real-time Visual Simulation Library). This paper shows the effectiveness of the system when it is applied to large-scale unsteady simulations, for which the conventional post-processing approach may no longer work, on high-performance parallel vector supercomputers. The system performs almost all of the visualization tasks on a computation server and uses compressed visualized image data for efficient communication between the server and the user terminal. We have introduced several techniques, including vectorization and parallelization, into the system to minimize the computational costs of the visualization tools. The performance of RVSLIB was evaluated by using an actual CFD code on an NEC SX-4. The computational time increase due to the concurrent visualization was at most 3% for a smaller (1.6 million) grid and less than 1% for a larger (6.2 million) one. (author)

Multithreading in vector processors

Science.gov (United States)

Evangelinos, Constantinos; Kim, Changhoan; Nair, Ravi

2018-01-16

In one embodiment, a system includes a processor having a vector processing mode and a multithreading mode. The processor is configured to operate on one thread per cycle in the multithreading mode. The processor includes a program counter register having a plurality of program counters, and the program counter register is vectorized. Each program counter in the program counter register represents a distinct corresponding thread of a plurality of threads. The processor is configured to execute the plurality of threads by activating the plurality of program counters in a round robin cycle.

Monitoring by Use of Clusters of Sensor-Data Vectors

Science.gov (United States)

Iverson, David L.

2007-01-01

The inductive monitoring system (IMS) is a system of computer hardware and software for automated monitoring of the performance, operational condition, physical integrity, and other aspects of the health of a complex engineering system (e.g., an industrial process line or a spacecraft). The input to the IMS consists of streams of digitized readings from sensors in the monitored system. The IMS determines the type and amount of any deviation of the monitored system from a nominal or normal ( healthy ) condition on the basis of a comparison between (1) vectors constructed from the incoming sensor data and (2) corresponding vectors in a database of nominal or normal behavior. The term inductive reflects the use of a process reminiscent of traditional mathematical induction to learn about normal operation and build the nominal-condition database. The IMS offers two major advantages over prior computational monitoring systems: The computational burden of the IMS is significantly smaller, and there is no need for abnormal-condition sensor data for training the IMS to recognize abnormal conditions. The figure schematically depicts the relationships among the computational processes effected by the IMS. Training sensor data are gathered during normal operation of the monitored system, detailed computational simulation of operation of the monitored system, or both. The training data are formed into vectors that are used to generate the database. The vectors in the database are clustered into regions that represent normal or nominal operation. Once the database has been generated, the IMS compares the vectors of incoming sensor data with vectors representative of the clusters. The monitored system is deemed to be operating normally or abnormally, depending on whether the vector of incoming sensor data is or is not, respectively, sufficiently close to one of the clusters. For this purpose, a distance between two vectors is calculated by a suitable metric (e.g., Euclidean

Space Vector Modulation Technique to Reduce Leakage Current of a Transformerless Three-Phase Four-Leg Photovoltaic System

Directory of Open Access Journals (Sweden)

F. Hasanzad

2017-06-01

Full Text Available Photovoltaic systems integrated to the grid have received considerable attention around the world. They can be connected to the electrical grid via galvanic isolation (transformer or without it (transformerless. Despite making galvanic isolation, low frequency transformer increases size, cost and losses. On the other hand, transformerless PV systems increase the leakage current (common-mode current, (CMC through the parasitic capacitors of the PV array. Inverter topology and switching technique are the most important parameters the leakage current depends on. As there is no need to extra hardware for switching scheme modification, it's an economical method for reducing leakage current. This paper evaluates the effect of different space vector modulation techniques on leakage current for a two-level three-phase four-leg inverter used in PV system. It proposes an efficient space vector modulation method which decreases the leakage current to below the quantity specified in VDE-0126-1-1 standard. furthermore, some other characteristics of the space vector modulation schemes that have not been significantly discussed for four-leg inverter, are considered, such as, modulation index, switching actions per period, common-mode voltage (CMV, and total harmonic distortion (THD. An extend software simulation using MATLAB/Simulink is performed to verify the effectiveness of the modulation technique.

ON THE ISSUE OF VECTOR CONTROL OF THE ASYNCHRONOUS MOTORS

Directory of Open Access Journals (Sweden)

B. I. Firago

2015-01-01

Full Text Available The paper considers the issue of one of the widespread types of vector control realization for the asynchronous motors with a short-circuited rotor. Of all more than 20 vector control types known presently, the following are applied most frequently: direct vector control with velocity pickup (VP, direct vector control without VP, indirect vector control with VP and indirect vector control without VP. Despite the fact that the asynchronous-motor indirect vector control without VP is the easiest and most spread, the absence of VP does not allow controlling the motor electromagnetic torque at zero velocity. This is the reason why for electric motor drives of such requirements they utilize the vector control with a velocity transducer. The systems of widest dissemination became the direct and indirect vector control systems with X-axis alignment of the synchronously rotating x–y-coordinate frame along the rotor flux-linkage vector inasmuch as this provides the simplest correlations for controlling variables. Although these two types of vector control are well presented in literature, a number of issues concerning their realization and practical application require further elaboration. These include: the block schemes adequate representation as consisted with the modern realization of vector control and clarification of the analytical expressions for evaluating the regulator parameters.The authors present a technique for evaluating the dynamics of an asynchronous electric motor drive with direct vector control and x-axis alignment along the vector of rotor flux linkage. The article offers a generalized structure of this vector control type with detailed description of its principal blocks: controlling system, frequency converter, and the asynchronous motor.The paper presents a direct vector control simulating model developed in the MatLab environment on the grounds of this structure. The authors illustrate the described technique with the results

Identification of Civil Engineering Structures using Vector ARMA Models

DEFF Research Database (Denmark)

Andersen, P.

The dissertation treats the matter of systems identification and modelling of load-bearing constructions using Auto-Regressive Moving Average Vector (ARMAV) models.......The dissertation treats the matter of systems identification and modelling of load-bearing constructions using Auto-Regressive Moving Average Vector (ARMAV) models....

Design of 2D Time-Varying Vector Fields

KAUST Repository

Chen, Guoning

2012-10-01

Design of time-varying vector fields, i.e., vector fields that can change over time, has a wide variety of important applications in computer graphics. Existing vector field design techniques do not address time-varying vector fields. In this paper, we present a framework for the design of time-varying vector fields, both for planar domains as well as manifold surfaces. Our system supports the creation and modification of various time-varying vector fields with desired spatial and temporal characteristics through several design metaphors, including streamlines, pathlines, singularity paths, and bifurcations. These design metaphors are integrated into an element-based design to generate the time-varying vector fields via a sequence of basis field summations or spatial constrained optimizations at the sampled times. The key-frame design and field deformation are also introduced to support other user design scenarios. Accordingly, a spatial-temporal constrained optimization and the time-varying transformation are employed to generate the desired fields for these two design scenarios, respectively. We apply the time-varying vector fields generated using our design system to a number of important computer graphics applications that require controllable dynamic effects, such as evolving surface appearance, dynamic scene design, steerable crowd movement, and painterly animation. Many of these are difficult or impossible to achieve via prior simulation-based methods. In these applications, the time-varying vector fields have been applied as either orientation fields or advection fields to control the instantaneous appearance or evolving trajectories of the dynamic effects. © 1995-2012 IEEE.

Design of 2D Time-Varying Vector Fields

KAUST Repository

Chen, Guoning; Kwatra, Vivek; Wei, Li-Yi; Hansen, Charles D.; Zhang, Eugene

2012-01-01

Design of time-varying vector fields, i.e., vector fields that can change over time, has a wide variety of important applications in computer graphics. Existing vector field design techniques do not address time-varying vector fields. In this paper, we present a framework for the design of time-varying vector fields, both for planar domains as well as manifold surfaces. Our system supports the creation and modification of various time-varying vector fields with desired spatial and temporal characteristics through several design metaphors, including streamlines, pathlines, singularity paths, and bifurcations. These design metaphors are integrated into an element-based design to generate the time-varying vector fields via a sequence of basis field summations or spatial constrained optimizations at the sampled times. The key-frame design and field deformation are also introduced to support other user design scenarios. Accordingly, a spatial-temporal constrained optimization and the time-varying transformation are employed to generate the desired fields for these two design scenarios, respectively. We apply the time-varying vector fields generated using our design system to a number of important computer graphics applications that require controllable dynamic effects, such as evolving surface appearance, dynamic scene design, steerable crowd movement, and painterly animation. Many of these are difficult or impossible to achieve via prior simulation-based methods. In these applications, the time-varying vector fields have been applied as either orientation fields or advection fields to control the instantaneous appearance or evolving trajectories of the dynamic effects. © 1995-2012 IEEE.

A load predictive energy management system for supercapacitor-battery hybrid energy storage system in solar application using the Support Vector Machine

International Nuclear Information System (INIS)

Chia, Yen Yee; Lee, Lam Hong; Shafiabady, Niusha; Isa, Dino

2015-01-01

Highlights: • A novel energy management system (EMS) for supercapacitor-battery hybrid energy storage system is implemented. • It is a load predictive EMS which is implemented using Support Vector Machine (SVM). • An optimum SVM load prediction model is obtained, which yields 100% accuracy in 0.004866 s of training time. • The implemented load predictive EMS is compared with the conventional sequential programming control. • This methodology reduces the number of power electronics used and prolong battery lifespan. - Abstract: This paper presents the use of a Support Vector Machine load predictive energy management system to control the energy flow between a solar energy source, a supercapacitor-battery hybrid energy storage combination and the load. The supercapacitor-battery hybrid energy storage system is deployed in a solar energy system to improve the reliability of delivered power. The combination of batteries and supercapacitors makes use of complementary characteristic that allow the overlapping of a battery’s high energy density with a supercapacitors’ high power density. This hybrid system produces a straightforward benefit over either individual system, by taking advantage of each characteristic. When the supercapacitor caters for the instantaneous peak power which prolongs the battery lifespan, it also minimizes the system cost and ensures a greener system by reducing the number of batteries. The resulting performance is highly dependent on the energy controls implemented in the system to exploit the strengths of the energy storage devices and minimize its weaknesses. It is crucial to use energy from the supercapacitor and therefore minimize jeopardizing the power system reliability especially when there is a sudden peak power demand. This study has been divided into two stages. The first stage is to obtain the optimum SVM load prediction model, and the second stage carries out the performance comparison of the proposed SVM-load predictive

Acoustic Biometric System Based on Preprocessing Techniques and Linear Support Vector Machines.

Science.gov (United States)

del Val, Lara; Izquierdo-Fuente, Alberto; Villacorta, Juan J; Raboso, Mariano

2015-06-17

Drawing on the results of an acoustic biometric system based on a MSE classifier, a new biometric system has been implemented. This new system preprocesses acoustic images, extracts several parameters and finally classifies them, based on Support Vector Machine (SVM). The preprocessing techniques used are spatial filtering, segmentation-based on a Gaussian Mixture Model (GMM) to separate the person from the background, masking-to reduce the dimensions of images-and binarization-to reduce the size of each image. An analysis of classification error and a study of the sensitivity of the error versus the computational burden of each implemented algorithm are presented. This allows the selection of the most relevant algorithms, according to the benefits required by the system. A significant improvement of the biometric system has been achieved by reducing the classification error, the computational burden and the storage requirements.

Controllability of linear vector fields on Lie groups

International Nuclear Information System (INIS)

Ayala, V.; Tirao, J.

1994-11-01

In this paper, we shall deal with a linear control system Σ defined on a Lie group G with Lie algebra g. The dynamic of Σ is determined by the drift vector field which is an element in the normalizer of g in the Lie algebra of all smooth vector field on G and by the control vectors which are elements in g considered as left-invariant vector fields. We characterize the normalizer of g identifying vector fields on G with C ∞ -functions defined on G into g. For this class of control systems we study algebraic conditions for the controllability problem. Indeed, we prove that if the drift vector field has a singularity then the Lie algebra rank condition is necessary for the controllability property, but in general this condition does not determine this property. On the other hand, we show that the rank (ad-rank) condition is sufficient for the controllability of Σ. In particular, we extend the fundamental Kalman's theorem when G is an Abelian connected Lie group. Our work is related with a paper of L. Markus and we also improve his results. (author). 7 refs

Perinatal systemic gene delivery using adeno-associated viral vectors

Directory of Open Access Journals (Sweden)

Rajvinder eKarda

2014-11-01

Full Text Available Neurodegenerative monogenic diseases can also affect a broad range of tissues and organs throughout the body. An effective treatment would require a systemic approach. The intravenous administration of novel therapies is ideal but is hampered by the inability of such drugs to cross the blood-brain barrier and precludes efficacy in the central nervous system. A number of these early lethal intractable diseases also present devastating irreversible pathology at birth or soon after. Therefore, any therapy would ideally be administered during the perinatal period to prevent, stop or ameliorate disease progression. The concept of perinatal gene therapy has moved a step further towards being a feasible approach to treating such disorders. This has primarily been driven by the recent discoveries that particular serotypes of adeno-associated virus (AAV gene delivery vectors have the ability to cross the blood-brain barrier following intravenous administration. Furthermore, this has been safely demonstrated in perinatal mice and non-human primates. This review focuses on the progress made in using AAV to achieve systemic transduction and what this means for developing perinatal gene therapy for early lethal neurodegenerative diseases.

Parameter Improved Particle Swarm Optimization Based Direct-Current Vector Control Strategy for Solar PV System

Directory of Open Access Journals (Sweden)

NAMMALVAR, P.

2018-02-01

Full Text Available This paper projects Parameter Improved Particle Swarm Optimization (PIPSO based direct current vector control technology for the integration of photovoltaic array in an AC micro-grid to enhance the system performance and stability. A photovoltaic system incorporated with AC micro-grid is taken as the pursuit of research study. The test system features two power converters namely, PV side converter which consists of DC-DC boost converter with Perturbation and Observe (P&O MPPT control to reap most extreme power from the PV array, and grid side converter which consists of Grid Side-Voltage Source Converter (GS-VSC with proposed direct current vector control strategy. The gain of the proposed controller is chosen from a set of three values obtained using apriori test and tuned through the PIPSO algorithm so that the Integral of Time multiplied Absolute Error (ITAE between the actual and the desired DC link capacitor voltage reaches a minimum and allows the system to extract maximum power from PV system, whereas the existing d-q control strategy is found to perform slowly to control the DC link voltage under varying solar insolation and load fluctuations. From simulation results, it is evident that the proposed optimal control technique provides robust control and improved efficiency.

Recent Advances in Non-viral Vectors for Gene Delivery

Science.gov (United States)

Guo, Xia; Huang, Leaf

2011-01-01

CONSPECTUS Non-viral vectors, typically based on cationic lipids or polymers, are preferred due to safety concerns with viral vectors. So far, non-viral vectors can proficiently transfect cells in culture, but obtaining efficient nanomedicines is far from evident. To overcome the hurdles associated with non-viral vectors is significant for improving delivery efficiency and therapeutic effect of nucleic acid. The drawbacks include the strong interaction of cationic delivery vehicles with blood components, uptake by the reticuloendothelial system (RES), toxicity, targeting ability of the carriers to the cells of interest, and so on. PEGylation is the predominant method used to reduce the binding of plasma proteins with non-viral vectors and minimize the clearance by RES after intravenous administration. The nanoparticles that are not rapidly cleared from the circulation accumulate in the tumors due to the enhanced permeability and retention effect, and the targeting ligands attached to the distal end of the PEGylated components allow binding to the receptors on the target cell surface. Neutral or anionic liposomes have been also developed for systemic delivery of nucleic acids in experimental animal model. Designing and synthesizing novel cationic lipids and polymers, and binding nucleic acid with peptides, targeting ligands, polymers, or environmentally sensitive moieties also attract many attentions for resolving the problems encountered by non-viral vectors. The application of inorganic nanoparticles in nucleic acid delivery is an emerging field, too. Recently, different classes of non-viral vectors appear to be converging and the features of different classes of non-viral vectors could be combined in one strategy. More hurdles associated with efficient nucleic acid delivery therefore might be expected to be overcome. In this account, we will focus on these novel non-viral vectors, which are classified into multifunctional hybrid nucleic acid vectors, novel

Genetic manipulation of endosymbionts to control vector and vector borne diseases

Directory of Open Access Journals (Sweden)

Jay Prakash Gupta

Full Text Available Vector borne diseases (VBD are on the rise because of failure of the existing methods of control of vector and vector borne diseases and the climate change. A steep rise of VBDs are due to several factors like selection of insecticide resistant vector population, drug resistant parasite population and lack of effective vaccines against the VBDs. Environmental pollution, public health hazard and insecticide resistant vector population indicate that the insecticides are no longer a sustainable control method of vector and vector-borne diseases. Amongst the various alternative control strategies, symbiont based approach utilizing endosymbionts of arthropod vectors could be explored to control the vector and vector borne diseases. The endosymbiont population of arthropod vectors could be exploited in different ways viz., as a chemotherapeutic target, vaccine target for the control of vectors. Expression of molecules with antiparasitic activity by genetically transformed symbiotic bacteria of disease-transmitting arthropods may serve as a powerful approach to control certain arthropod-borne diseases. Genetic transformation of symbiotic bacteria of the arthropod vector to alter the vector’s ability to transmit pathogen is an alternative means of blocking the transmission of VBDs. In Indian scenario, where dengue, chikungunya, malaria and filariosis are prevalent, paratransgenic based approach can be used effectively. [Vet World 2012; 5(9.000: 571-576

Using Vector Projection Method to evaluate maintainability of mechanical system in design review

International Nuclear Information System (INIS)

Chen Lu; Cai Jianguo

2003-01-01

Maintainability of a mechanical system is one of the system design parameters that has a great impact in terms of ease of maintenance. In this article, based on the definition of the terms of maintenance and maintainability, an important tool of Design for Maintenance is developed as a way to improve maintainability through design. A set of standard and organized guidelines is provided and maintainability factors in terms of physical design, logistics support and ergonomics are identified. As a specific application of design review, a methodology so called Vector Projection Method is developed to evaluate the maintainability of the mechanical system. Lastly, an example is discussed

Vector assembly of colloids on monolayer substrates

Science.gov (United States)

Jiang, Lingxiang; Yang, Shenyu; Tsang, Boyce; Tu, Mei; Granick, Steve

2017-06-01

The key to spontaneous and directed assembly is to encode the desired assembly information to building blocks in a programmable and efficient way. In computer graphics, raster graphics encodes images on a single-pixel level, conferring fine details at the expense of large file sizes, whereas vector graphics encrypts shape information into vectors that allow small file sizes and operational transformations. Here, we adapt this raster/vector concept to a 2D colloidal system and realize `vector assembly' by manipulating particles on a colloidal monolayer substrate with optical tweezers. In contrast to raster assembly that assigns optical tweezers to each particle, vector assembly requires a minimal number of optical tweezers that allow operations like chain elongation and shortening. This vector approach enables simple uniform particles to form a vast collection of colloidal arenes and colloidenes, the spontaneous dissociation of which is achieved with precision and stage-by-stage complexity by simply removing the optical tweezers.

Modified montmorillonite as vector for gene delivery.

Science.gov (United States)

Lin, Feng-Huei; Chen, Chia-Hao; Cheng, Winston T K; Kuo, Tzang-Fu

2006-06-01

Currently, gene delivery systems can be divided into two parts: viral or non-viral vectors. In general, viral vectors have a higher efficiency on gene delivery. However, they may sometimes provoke mutagenesis and carcinogenesis once re-activating in human body. Lots of non-viral vectors have been developed that tried to solve the problems happened on viral vectors. Unfortunately, most of non-viral vectors showed relatively lower transfection rate. The aim of this study is to develop a non-viral vector for gene delivery system. Montmorillonite (MMT) is one of clay minerals that consist of hydrated aluminum with Si-O tetrahedrons on the bottom of the layer and Al-O(OH)2 octahedrons on the top. The inter-layer space is about 12 A. The room is not enough to accommodate DNA for gene delivery. In the study, the cationic hexadecyltrimethylammonium (HDTMA) will be intercalated into the interlayer of MMT as a layer expander to expand the layer space for DNA accommodation. The optimal condition for the preparation of DNA-HDTMA-MMT is as follows: 1 mg of 1.5CEC HDTMA-MMT was prepared under pH value of 10.7 and with soaking time for 2 h. The DNA molecules can be protected from nuclease degradation, which can be proven by the electrophoresis analysis. DNA was successfully transfected into the nucleus of human dermal fibroblast and expressed enhanced green fluorescent protein (EGFP) gene with green fluorescence emission. The HDTMA-MMT has a great potential as a vector for gene delivery in the future.

Emerging vector borne diseases – incidence through vectors

Directory of Open Access Journals (Sweden)

Sara eSavic

2014-12-01

Full Text Available Vector borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowdays, in intercontinetal countries, there is a struggle with emerging diseases which have found their way to appear through vectors. Vector borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector borne infectious diseases and disease outbreaks. It could affect the range and popultion of pathogens, host and vectors, transmission season, etc. Reliable surveilance for diseases that are most likely to emerge is required. Canine vector borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, erlichiosis, leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fudamental role at primeraly prevention and then treatment of vector borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases.During a four year period, from 2009-2013, a total number of 551 dog samples were analysed for vector borne diseases (borreliosis, babesiosis, erlichiosis, anaplasmosis, dirofilariosis and leishmaniasis in routine laboratory work. The analysis were done by serological tests – ELISA for borreliosis, dirofilariosis and leishmaniasis, modified Knott test for dirofilariosis and blood smear for babesiosis, erlichiosis and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on avarege more then half of the samples

The consequences of poor vectorization

CERN Multimedia

CERN. Geneva

2016-01-01

This talk briefly discusses the vectorization problem and how it impacts scientific and engineering systems. A simple cost model of designing such system in context of different phases of software lifetime is considered. Finally a concept for scalable solution is presented.

Product demand forecasts using wavelet kernel support vector machine and particle swarm optimization in manufacture system

Science.gov (United States)

Wu, Qi

2010-03-01

Demand forecasts play a crucial role in supply chain management. The future demand for a certain product is the basis for the respective replenishment systems. Aiming at demand series with small samples, seasonal character, nonlinearity, randomicity and fuzziness, the existing support vector kernel does not approach the random curve of the sales time series in the space (quadratic continuous integral space). In this paper, we present a hybrid intelligent system combining the wavelet kernel support vector machine and particle swarm optimization for demand forecasting. The results of application in car sale series forecasting show that the forecasting approach based on the hybrid PSOWv-SVM model is effective and feasible, the comparison between the method proposed in this paper and other ones is also given, which proves that this method is, for the discussed example, better than hybrid PSOv-SVM and other traditional methods.

Vector-vector production in photon-photon interactions

International Nuclear Information System (INIS)

Ronan, M.T.

1988-01-01

Measurements of exclusive untagged /rho/ 0 /rho/ 0 , /rho//phi/, K/sup *//bar K//sup */, and /rho/ω production and tagged /rho/ 0 /rho/ 0 production in photon-photon interactions by the TPC/Two-Gamma experiment are reviewed. Comparisons to the results of other experiments and to models of vector-vector production are made. Fits to the data following a four quark model prescription for vector meson pair production are also presented. 10 refs., 9 figs

Two-host, two-vector basic reproduction ratio (R(0 for bluetongue.

Directory of Open Access Journals (Sweden)

Joanne Turner

Full Text Available Mathematical formulations for the basic reproduction ratio (R(0 exist for several vector-borne diseases. Generally, these are based on models of one-host, one-vector systems or two-host, one-vector systems. For many vector borne diseases, however, two or more vector species often co-occur and, therefore, there is a need for more complex formulations. Here we derive a two-host, two-vector formulation for the R(0 of bluetongue, a vector-borne infection of ruminants that can have serious economic consequences; since 1998 for example, it has led to the deaths of well over 1 million sheep in Europe alone. We illustrate our results by considering the situation in South Africa, where there are two major hosts (sheep, cattle and two vector species with differing ecologies and competencies as vectors, for which good data exist. We investigate the effects on R(0 of differences in vector abundance, vector competence and vector host preference between vector species. Our results indicate that R(0 can be underestimated if we assume that there is only one vector transmitting the infection (when there are in fact two or more and/or vector host preferences are overlooked (unless the preferred host is less beneficial or more abundant. The two-host, one-vector formula provides a good approximation when the level of cross-infection between vector species is very small. As this approaches the level of intraspecies infection, a combination of the two-host, one-vector R(0 for each vector species becomes a better estimate. Otherwise, particularly when the level of cross-infection is high, the two-host, two-vector formula is required for accurate estimation of R(0. Our results are equally relevant to Europe, where at least two vector species, which co-occur in parts of the south, have been implicated in the recent epizootic of bluetongue.

Vector-Parallel processing of the successive overrelaxation method

International Nuclear Information System (INIS)

Yokokawa, Mitsuo

1988-02-01

Successive overrelaxation method, called SOR method, is one of iterative methods for solving linear system of equations, and it has been calculated in serial with a natural ordering in many nuclear codes. After the appearance of vector processors, this natural SOR method has been changed for the parallel algorithm such as hyperplane or red-black method, in which the calculation order is modified. These methods are suitable for vector processors, and more high-speed calculation can be obtained compared with the natural SOR method on vector processors. In this report, a new scheme named 4-colors SOR method is proposed. We find that the 4-colors SOR method can be executed on vector-parallel processors and it gives the most high-speed calculation among all SOR methods according to results of the vector-parallel execution on the Alliant FX/8 multiprocessor system. It is also shown that the theoretical optimal acceleration parameters are equal among five different ordering SOR methods, and the difference between convergence rates of these SOR methods are examined. (author)

Manga Vectorization and Manipulation with Procedural Simple Screentone.

Science.gov (United States)

Yao, Chih-Yuan; Hung, Shih-Hsuan; Li, Guo-Wei; Chen, I-Yu; Adhitya, Reza; Lai, Yu-Chi

2017-02-01

Manga are a popular artistic form around the world, and artists use simple line drawing and screentone to create all kinds of interesting productions. Vectorization is helpful to digitally reproduce these elements for proper content and intention delivery on electronic devices. Therefore, this study aims at transforming scanned Manga to a vector representation for interactive manipulation and real-time rendering with arbitrary resolution. Our system first decomposes the patch into rough Manga elements including possible borders and shading regions using adaptive binarization and screentone detector. We classify detected screentone into simple and complex patterns: our system extracts simple screentone properties for refining screentone borders, estimating lighting, compensating missing strokes inside screentone regions, and later resolution independently rendering with our procedural shaders. Our system treats the others as complex screentone areas and vectorizes them with our proposed line tracer which aims at locating boundaries of all shading regions and polishing all shading borders with the curve-based Gaussian refiner. A user can lay down simple scribbles to cluster Manga elements intuitively for the formation of semantic components, and our system vectorizes these components into shading meshes along with embedded Bézier curves as a unified foundation for consistent manipulation including pattern manipulation, deformation, and lighting addition. Our system can real-time and resolution independently render the shading regions with our procedural shaders and drawing borders with the curve-based shader. For Manga manipulation, the proposed vector representation can be not only magnified without artifacts but also deformed easily to generate interesting results.

Rare Hadronic B Decays to Vector, Axial-Vector and Tensors

International Nuclear Information System (INIS)

Gao, Y.Y.

2011-01-01

The authors review BABAR measurements of several rare B decays, including vector-axial-vector decays B ± → φK 1 ± (1270), B ± → φ K 1 ± (1400) and B ± → b 1 # -+ρ# ± , vector-vector decays B ± → φK* ± (1410), B 0 → K* 0 (bar K)* 0 , B 0 → K*0K*0 and B 0 → K*+K*-, vector-tensor decays B ± → φK* 2 (1430) ± and φK 2 (1770)/ ± (1820), and vector-scalar decays B ± → φK* 0 (1430) ± . Understanding the observed polarization pattern requires amplitude contributions from an uncertain source.

VectorH: taking SQL-on-Hadoop to the next level

NARCIS (Netherlands)

M. Switakowski; A. Costea (Andrei); A. Ionescu (Adrian); B. Raducanu (Bogdan); C. Bârca; J. Sompolski (Juliusz); A. Łuszczak; M. Szafranski (Michal); G. De Nijs; P.A. Boncz (Peter)

2016-01-01

htmlabstractIn this paper we describe VectorH: a new SQL-on-Hadoop system built on top of the fast Vectorwise analytical database system. VectorH achieves fault tolerance and scalable data storage by relying on HDFS, extending the state-of-the-art in SQL-on-Hadoop systems by instrumenting the HDFS

Bioreactor production of recombinant herpes simplex virus vectors.

Science.gov (United States)

Knop, David R; Harrell, Heather

2007-01-01

Serotypical application of herpes simplex virus (HSV) vectors to gene therapy (type 1) and prophylactic vaccines (types 1 and 2) has garnered substantial clinical interest recently. HSV vectors and amplicons have also been employed as helper virus constructs for manufacture of the dependovirus adeno-associated virus (AAV). Large quantities of infectious HSV stocks are requisite for these therapeutic applications, requiring a scalable vector manufacturing and processing platform comprised of unit operations which accommodate the fragility of HSV. In this study, production of a replication deficient rHSV-1 vector bearing the rep and cap genes of AAV-2 (denoted rHSV-rep2/cap2) was investigated. Adaptation of rHSV production from T225 flasks to a packed bed, fed-batch bioreactor permitted an 1100-fold increment in total vector production without a decrease in specific vector yield (pfu/cell). The fed-batch bioreactor system afforded a rHSV-rep2/cap2 vector recovery of 2.8 x 10(12) pfu. The recovered vector was concentrated by tangential flow filtration (TFF), permitting vector stocks to be formulated at greater than 1.5 x 10(9) pfu/mL.

Gateway-compatible vectors for high-throughput protein expression in pro- and eukaryotic cell-free systems.

Science.gov (United States)

Gagoski, Dejan; Mureev, Sergey; Giles, Nichole; Johnston, Wayne; Dahmer-Heath, Mareike; Škalamera, Dubravka; Gonda, Thomas J; Alexandrov, Kirill

2015-02-10

Although numerous techniques for protein expression and production are available the pace of genome sequencing outstrips our ability to analyze the encoded proteins. To address this bottleneck, we have established a system for parallelized cloning, DNA production and cell-free expression of large numbers of proteins. This system is based on a suite of pCellFree Gateway destination vectors that utilize a Species Independent Translation Initiation Sequence (SITS) that mediates recombinant protein expression in any in vitro translation system. These vectors introduce C or N terminal EGFP and mCherry fluorescent and affinity tags, enabling direct analysis and purification of the expressed proteins. To maximize throughput and minimize the cost of protein production we combined Gateway cloning with Rolling Circle DNA Amplification. We demonstrate that as little as 0.1 ng of plasmid DNA is sufficient for template amplification and production of recombinant human protein in Leishmania tarentolae and Escherichia coli cell-free expression systems. Our experiments indicate that this approach can be applied to large gene libraries as it can be reliably performed in multi-well plates. The resulting protein expression pipeline provides a valuable new tool for applications of the post genomic era. Copyright © 2014 Elsevier B.V. All rights reserved.

Singular vectors, predictability and ensemble forecasting for weather and climate

International Nuclear Information System (INIS)

Palmer, T N; Zanna, Laure

2013-01-01

The local instabilities of a nonlinear dynamical system can be characterized by the leading singular vectors of its linearized operator. The leading singular vectors are perturbations with the greatest linear growth and are therefore key in assessing the system’s predictability. In this paper, the analysis of singular vectors for the predictability of weather and climate and ensemble forecasting is discussed. An overview of the role of singular vectors in informing about the error growth rate in numerical models of the atmosphere is given. This is followed by their use in the initialization of ensemble weather forecasts. Singular vectors for the ocean and coupled ocean–atmosphere system in order to understand the predictability of climate phenomena such as ENSO and meridional overturning circulation are reviewed and their potential use to initialize seasonal and decadal forecasts is considered. As stochastic parameterizations are being implemented, some speculations are made about the future of singular vectors for the predictability of weather and climate for theoretical applications and at the operational level. This article is part of a special issue of Journal of Physics A: Mathematical and Theoretical devoted to ‘Lyapunov analysis: from dynamical systems theory to applications’. (review)

Design, development and evaluation of an online grading system for peeled pistachios equipped with machine vision technology and support vector machine

Directory of Open Access Journals (Sweden)

Hosein Nouri-Ahmadabadi

2017-12-01

Full Text Available In this study, an intelligent system based on combined machine vision (MV and Support Vector Machine (SVM was developed for sorting of peeled pistachio kernels and shells. The system was composed of conveyor belt, lighting box, camera, processing unit and sorting unit. A color CCD camera was used to capture images. The images were digitalized by a capture card and transferred to a personal computer for further analysis. Initially, images were converted from RGB color space to HSV color ones. For segmentation of the acquired images, H-component in the HSV color space and Otsu thresholding method were applied. A feature vector containing 30 color features was extracted from the captured images. A feature selection method based on sensitivity analysis was carried out to select superior features. The selected features were presented to SVM classifier. Various SVM models having a different kernel function were developed and tested. The SVM model having cubic polynomial kernel function and 38 support vectors achieved the best accuracy (99.17% and then was selected to use in online decision-making unit of the system. By launching the online system, it was found that limiting factors of the system capacity were related to the hardware parts of the system (conveyor belt and pneumatic valves used in the sorting unit. The limiting factors led to a distance of 8 mm between the samples. The overall accuracy and capacity of the sorter were obtained 94.33% and 22.74 kg/h, respectively. Keywords: Pistachio kernel, Sorting, Machine vision, Sensitivity analysis, Support vector machine

Breast cancer risk assessment and diagnosis model using fuzzy support vector machine based expert system

Science.gov (United States)

Dheeba, J.; Jaya, T.; Singh, N. Albert

2017-09-01

Classification of cancerous masses is a challenging task in many computerised detection systems. Cancerous masses are difficult to detect because these masses are obscured and subtle in mammograms. This paper investigates an intelligent classifier - fuzzy support vector machine (FSVM) applied to classify the tissues containing masses on mammograms for breast cancer diagnosis. The algorithm utilises texture features extracted using Laws texture energy measures and a FSVM to classify the suspicious masses. The new FSVM treats every feature as both normal and abnormal samples, but with different membership. By this way, the new FSVM have more generalisation ability to classify the masses in mammograms. The classifier analysed 219 clinical mammograms collected from breast cancer screening laboratory. The tests made on the real clinical mammograms shows that the proposed detection system has better discriminating power than the conventional support vector machine. With the best combination of FSVM and Laws texture features, the area under the Receiver operating characteristic curve reached .95, which corresponds to a sensitivity of 93.27% with a specificity of 87.17%. The results suggest that detecting masses using FSVM contribute to computer-aided detection of breast cancer and as a decision support system for radiologists.

Using Covariant Lyapunov Vectors to Understand Spatiotemporal Chaos in Fluids

Science.gov (United States)

Paul, Mark; Xu, Mu; Barbish, Johnathon; Mukherjee, Saikat

2017-11-01

The spatiotemporal chaos of fluids present many difficult and fascinating challenges. Recent progress in computing covariant Lyapunov vectors for a variety of model systems has made it possible to probe fundamental ideas from dynamical systems theory including the degree of hyperbolicity, the fractal dimension, the dimension of the inertial manifold, and the decomposition of the dynamics into a finite number of physical modes and spurious modes. We are interested in building upon insights such as these for fluid systems. We first demonstrate the power of covariant Lyapunov vectors using a system of maps on a lattice with a nonlinear coupling. We then compute the covariant Lyapunov vectors for chaotic Rayleigh-Bénard convection for experimentally accessible conditions. We show that chaotic convection is non-hyperbolic and we quantify the spatiotemporal features of the spectrum of covariant Lyapunov vectors. NSF DMS-1622299 and DARPA/DSO Models, Dynamics, and Learning (MoDyL).

A support vector machine integrated system for the classification of operation anomalies in nuclear components and systems

International Nuclear Information System (INIS)

Rocco S, Claudio M.; Zio, Enrico

2007-01-01

A support vector machine (SVM) approach to the classification of transients in nuclear power plants is presented. SVM is a machine-learning algorithm that has been successfully used in pattern recognition for cluster analysis. In the present work, single- and multiclass SVM are combined into a hierarchical structure for distinguishing among transients in nuclear systems on the basis of measured data. An example of application of the approach is presented with respect to the classification of anomalies and malfunctions occurring in the feedwater system of a boiling water reactor. The data used in the example are provided by the HAMBO simulator of the Halden Reactor Project

Vector analysis

CERN Document Server

Brand, Louis

2006-01-01

The use of vectors not only simplifies treatments of differential geometry, mechanics, hydrodynamics, and electrodynamics, but also makes mathematical and physical concepts more tangible and easy to grasp. This text for undergraduates was designed as a short introductory course to give students the tools of vector algebra and calculus, as well as a brief glimpse into these subjects' manifold applications. The applications are developed to the extent that the uses of the potential function, both scalar and vector, are fully illustrated. Moreover, the basic postulates of vector analysis are brou

The evaporative vector: Homogeneous systems

International Nuclear Information System (INIS)

Klots, C.E.

1987-05-01

Molecular beams of van der Waals molecules are the subject of much current research. Among the methods used to form these beams, three-sputtering, laser ablation, and the sonic nozzle expansion of neat gases - yield what are now recognized to be ''warm clusters.'' They contain enough internal energy to undergo a number of first-order processes, in particular that of evaporation. Because of this evaporation and its attendant cooling, the properties of such clusters are time-dependent. The states of matter which can be arrived at via an evaporative vector on a typical laboratory time-scale are discussed. Topics include the (1) temperatures, (2) metastability, (3) phase transitions, (4) kinetic energies of fragmentation, and (5) the expression of magical properties, all for evaporating homogeneous clusters

Biosensor method and system based on feature vector extraction

Science.gov (United States)

Greenbaum, Elias [Knoxville, TN; Rodriguez, Jr., Miguel; Qi, Hairong [Knoxville, TN; Wang, Xiaoling [San Jose, CA

2012-04-17

A method of biosensor-based detection of toxins comprises the steps of providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time-frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal.

Broad patterns in domestic vector-borne Trypanosoma cruzi transmission dynamics: synanthropic animals and vector control.

Science.gov (United States)

Peterson, Jennifer K; Bartsch, Sarah M; Lee, Bruce Y; Dobson, Andrew P

2015-10-22

Chagas disease (caused by Trypanosoma cruzi) is the most important neglected tropical disease (NTD) in Latin America, infecting an estimated 5.7 million people in the 21 countries where it is endemic. It is one of the NTDs targeted for control and elimination by the 2020 London Declaration goals, with the first goal being to interrupt intra-domiciliary vector-borne T. cruzi transmission. A key question in domestic T. cruzi transmission is the role that synanthropic animals play in T. cruzi transmission to humans. Here, we ask, (1) do synanthropic animals need to be targeted in Chagas disease prevention policies?, and (2) how does the presence of animals affect the efficacy of vector control? We developed a simple mathematical model to simulate domestic vector-borne T. cruzi transmission and to specifically examine the interaction between the presence of synanthropic animals and effects of vector control. We used the model to explore how the interactions between triatomine bugs, humans and animals impact the number and proportion of T. cruzi-infected bugs and humans. We then examined how T. cruzi dynamics change when control measures targeting vector abundance are introduced into the system. We found that the presence of synanthropic animals slows the speed of T. cruzi transmission to humans, and increases the sensitivity of T. cruzi transmission dynamics to vector control measures at comparable triatomine carrying capacities. However, T. cruzi transmission is amplified when triatomine carrying capacity increases with the abundance of syntathoropic hosts. Our results suggest that in domestic T. cruzi transmission scenarios where no vector control measures are in place, a reduction in synanthropic animals may slow T. cruzi transmission to humans, but it would not completely eliminate transmission. To reach the 2020 goal of interrupting intra-domiciliary T. cruzi transmission, it is critical to target vector populations. Additionally, where vector control measures

Vectors and Rotations in 3-Dimensions: Vector Algebra for the C++ Programmer

Science.gov (United States)

2016-12-01

release; distribution is unlimited. 1. Introduction This report describes 2 C++ classes: a Vector class for performing vector algebra in 3-dimensional...ARL-TR-7894•DEC 2016 US Army Research Laboratory Vectors and Rotations in 3-Dimensions:Vector Algebra for the C++ Programmer by Richard Saucier...Army Research Laboratory Vectors and Rotations in 3-Dimensions:Vector Algebra for the C++ Programmer by Richard Saucier Survivability/Lethality

Lagrangian vector field and Lagrangian formulation of partial differential equations

Directory of Open Access Journals (Sweden)

M.Chen

2005-01-01

Full Text Available In this paper we consider the Lagrangian formulation of a system of second order quasilinear partial differential equations. Specifically we construct a Lagrangian vector field such that the flows of the vector field satisfy the original system of partial differential equations.

Completeness of the System of Root Vectors of 2 × 2 Upper Triangular Infinite-Dimensional Hamiltonian Operators in Symplectic Spaces and Applications

Institute of Scientific and Technical Information of China (English)

Hua WANG; ALATANCANG; Junjie HUANG

2011-01-01

The authors investigate the completeness of the system of eigen or root vectors of the 2 x 2 upper triangular infinite-dimensional Hamiltonian operator H0.First,the geometrical multiplicity and the algebraic index of the eigenvalue of H0 are considered.Next,some necessary and sufficient conditions for the completeness of the system of eigen or root vectors of H0 are obtained. Finally,the obtained results are tested in several examples.

On spectral resolutions of differential vector-operators

International Nuclear Information System (INIS)

Ashurov, R.R.; Sokolov, M.S.

2004-04-01

We show that spectral resolutions of differential vector-operators may be represented as a specific direct sum integral operator with a kernel written in terms of generalized vector-operator eigenfunctions. Then we prove that a generalized eigenfunction measurable with respect to the spectral parameter may be decomposed using a set of analytical defining systems of coordinate operators. (author)

Researches on Key Algorithms in Analogue Seismogram Records Vectorization

Directory of Open Access Journals (Sweden)

Maofa WANG

2014-09-01

Full Text Available History paper seismograms are very important information for earthquake monitoring and prediction, and the vectorization of paper seismograms is a very import problem to be resolved. In our study, a new tracing algorithm for simulated seismogram curves based on visual filed feature is presented. We also give out the technological process to vectorizing simulated seismograms, and an analog seismic record vectorization system has been accomplished independently. Using it, we can precisely and speedy vectorize analog seismic records (need professionals to participate interactively.

An Adaptive Supervisory Sliding Fuzzy Cerebellar Model Articulation Controller for Sensorless Vector-Controlled Induction Motor Drive Systems

Directory of Open Access Journals (Sweden)

Shun-Yuan Wang

2015-03-01

Full Text Available This paper presents the implementation of an adaptive supervisory sliding fuzzy cerebellar model articulation controller (FCMAC in the speed sensorless vector control of an induction motor (IM drive system. The proposed adaptive supervisory sliding FCMAC comprised a supervisory controller, integral sliding surface, and an adaptive FCMAC. The integral sliding surface was employed to eliminate steady-state errors and enhance the responsiveness of the system. The adaptive FCMAC incorporated an FCMAC with a compensating controller to perform a desired control action. The proposed controller was derived using the Lyapunov approach, which guarantees learning-error convergence. The implementation of three intelligent control schemes—the adaptive supervisory sliding FCMAC, adaptive sliding FCMAC, and adaptive sliding CMAC—were experimentally investigated under various conditions in a realistic sensorless vector-controlled IM drive system. The root mean square error (RMSE was used as a performance index to evaluate the experimental results of each control scheme. The analysis results indicated that the proposed adaptive supervisory sliding FCMAC substantially improved the system performance compared with the other control schemes.

Vectorization, parallelization and porting of nuclear codes (porting). Progress report fiscal 1998

International Nuclear Information System (INIS)

Nemoto, Toshiyuki; Kawai, Wataru; Ishizuki, Shigeru; Kawasaki, Nobuo; Kume, Etsuo; Adachi, Masaaki; Ogasawara, Shinobu

2000-03-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system, the AP3000 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 12 codes in fiscal 1998. These results are reported in 3 parts, i.e., the vectorization and parallelization on vector processors part, the parallelization on scalar processors part and the porting part. In this report, we describe the porting. In this porting part, the porting of Monte Carlo N-Particle Transport code MCNP4B2 and Reactor Safety Analysis code RELAP5 on the AP3000 are described. In the vectorization and parallelization on vector processors part, the vectorization of General Tokamak Circuit Simulation Program code GTCSP, the vectorization and parallelization of Molecular Dynamics Ntv Simulation code MSP2, Eddy Current Analysis code EDDYCAL, Thermal Analysis Code for Test of Passive Cooling System by HENDEL T2 code THANPACST2 and MHD Equilibrium code SELENEJ on the VPP500 are described. In the parallelization on scalar processors part, the parallelization of Monte Carlo N-Particle Transport code MCNP4B2, Plasma Hydrodynamics code using Cubic Interpolated propagation Method PHCIP and Vectorized Monte Carlo code (continuous energy model/multi-group model) MVP/GMVP on the Paragon are described. (author)

Measurement of Charmless B to Vector-Vector decays at BaBar

International Nuclear Information System (INIS)

Olaiya, Emmanuel

2011-01-01

The authors present results of B → vector-vector (VV) and B → vector-axial vector (VA) decays B 0 → φX(X = φ,ρ + or ρ 0 ), B + → φK (*)+ , B 0 → K*K*, B 0 → ρ + b 1 - and B + → K* 0 α 1 + . The largest dataset used for these results is based on 465 x 10 6 Υ(4S) → B(bar B) decays, collected with the BABAR detector at the PEP-II B meson factory located at the Stanford Linear Accelerator Center (SLAC). Using larger datasets, the BABAR experiment has provided more precise B → VV measurements, further supporting the smaller than expected longitudinal polarization fraction of B → φK*. Additional B meson to vector-vector and vector-axial vector decays have also been studied with a view to shedding light on the polarization anomaly. Taking into account the available errors, we find no disagreement between theory and experiment for these additional decays.

Systemic Errors in Quantitative Polymerase Chain Reaction Titration of Self-Complementary Adeno-Associated Viral Vectors and Improved Alternative Methods

Science.gov (United States)

Fagone, Paolo; Wright, J. Fraser; Nathwani, Amit C.; Nienhuis, Arthur W.; Davidoff, Andrew M.

2012-01-01

Abstract Self-complementary AAV (scAAV) vector genomes contain a covalently closed hairpin derived from a mutated inverted terminal repeat that connects the two monomer single-stranded genomes into a head-to-head or tail-to-tail dimer. We found that during quantitative PCR (qPCR) this structure inhibits the amplification of proximal amplicons and causes the systemic underreporting of copy number by as much as 10-fold. We show that cleavage of scAAV vector genomes with restriction endonuclease to liberate amplicons from the covalently closed terminal hairpin restores quantitative amplification, and we implement this procedure in a simple, modified qPCR titration method for scAAV vectors. In addition, we developed and present an AAV genome titration procedure based on gel electrophoresis that requires minimal sample processing and has low interassay variability, and as such is well suited for the rigorous quality control demands of clinical vector production facilities. PMID:22428975

A novel and highly efficient production system for recombinant adeno-associated virus vector.

Science.gov (United States)

Wu, Zhijian; Wu, Xiaobing; Cao, Hui; Dong, Xiaoyan; Wang, Hong; Hou, Yunde

2002-02-01

Recombinant adeno-associated virus (rAAV) has proven to be a promising gene delivery vector for human gene therapy. However, its application has been limited by difficulty in obtaining enough quantities of high-titer vector stocks. In this paper, a novel and highly efficient production system for rAAV is described. A recombinant herpes simplex virus type 1 (rHSV-1) designated HSV1-rc/DeltaUL2, which expressed adeno-associated virus type2 (AAV-2) Rep and Cap proteins, was constructed previously. The data confirmed that its functions were to support rAAV replication and packaging, and the generated rAAV was infectious. Meanwhile, an rAAV proviral cell line designated BHK/SG2, which carried the green fluorescent protein (GFP) gene expression cassette, was established by transfecting BHK-21 cells with rAAV vector plasmid pSNAV-2-GFP. Infecting BHK/SG2 with HSV1-rc/DeltaUL2 at an MOI of 0.1 resulted in the optimal yields of rAAV, reaching 250 transducing unit (TU) or 4.28x10(4) particles per cell. Therefore, compared with the conventional transfection method, the yield of rAAV using this "one proviral cell line, one helper virus" strategy was increased by two orders of magnitude. Large-scale production of rAAV can be easily achieved using this strategy and might meet the demands for clinical trials of rAAV-mediated gene therapy.

Interactions between parasites and insects vectors

Directory of Open Access Journals (Sweden)

Hilary Hurd

1994-01-01

Full Text Available This review stresses the importance of studies that will provide a basic understanding of the pathology of parasite-infected vector insects. This knowledge should be a vital component of the very focussed initiatives currently being funded in the areas of vector control. Vector fecundity reduction is discussed as an example of such pathology. Underlying mechanisms are being investigated in a model system, Hymenolepis diminuta-infected Tenebrio molitor and in Onchocerca-infected blackflies and Plasmodium-infected Anopheles stephensi. In all cases, host vitellogenesis is disrupted by the parasite and, in the tapeworm/beetle model, interaction between the parasite and the endocrine control of the insect's reproductive physiology has been demonstrated.

Synthetic Aperture Vector Flow Imaging

DEFF Research Database (Denmark)

Villagómez Hoyos, Carlos Armando

The main objective of this project was to continue the development of a synthetic aperture vector flow estimator. This type of estimator is capable of overcoming two of the major limitations in conventional ultrasound systems: 1) the inability to scan large region of interest with high temporal......, this thesis showed that novel information can be obtained with vector velocity methods providing quantitative estimates of blood flow and insight into the complexity of the hemodynamics dynamics. This could give the clinician a new tool in assessment and treatment of a broad range of diseases....

Vector control of three-phase AC machines system development in the practice

CERN Document Server

Quang, Nguyen Phung; Dittrich, J

2015-01-01

This book addresses the vector control of three-phase AC machines, in particular induction motors with squirrel-cage rotors (IM), permanent magnet synchronous motors (PMSM) and doubly-fed induction machines (DFIM), from a practical design and development perspective. The main focus is on the application of IM and PMSM in electrical drive systems, where field-orientated control has been successfully established in practice. It also discusses the use of grid-voltage oriented control of DFIMs in wind power plants. This second, enlarged edition includes new insights into flatness-based  nonlinear

Forecasting systems reliability based on support vector regression with genetic algorithms

International Nuclear Information System (INIS)

Chen, K.-Y.

2007-01-01

This study applies a novel neural-network technique, support vector regression (SVR), to forecast reliability in engine systems. The aim of this study is to examine the feasibility of SVR in systems reliability prediction by comparing it with the existing neural-network approaches and the autoregressive integrated moving average (ARIMA) model. To build an effective SVR model, SVR's parameters must be set carefully. This study proposes a novel approach, known as GA-SVR, which searches for SVR's optimal parameters using real-value genetic algorithms, and then adopts the optimal parameters to construct the SVR models. A real reliability data for 40 suits of turbochargers were employed as the data set. The experimental results demonstrate that SVR outperforms the existing neural-network approaches and the traditional ARIMA models based on the normalized root mean square error and mean absolute percentage error

First measurement of the helicity-dependent vector gamma)vector(p)->p eta differential cross-section

CERN Document Server

Ahrens, J; Aulenbacher, K; Beck, R; Drechsel, D; Von Harrach, D; Heid, E; Altieri, S; Annand, J R M; Anton, G; Bradtke, C; Görtz, S; Harmsen, J; Braghieri, A; D'Hose, N; Dutz, H; Grabmayr, P; Hansen, K; Hasegawa, S; Hasegawa, T; Helbing, K; Holvoet, H; Van Hoorebeke, L; Horikawa, N; Iwata, T; Jahn, O; Jennewein, P; Kageya, T; Kiel, B; Klein, F; Kondratiev, R; Kossert, K; Krimmer, J; Lang, M; Lannoy, B; Leukel, R; Lisin, V; Matsuda, T; McGeorge, J C; Meier, A; Menze, D; Meyer, Werner T; Michel, T; Naumann, J; Panzeri, A; Pedroni, P; Pinelli, T; Preobrajenski, I; Radtke, E; Reichert, E; Reicherz, G; Rohlof, C; Rosner, G; Ryckbosch, D; Sauer, M C; Schoch, B; Schumacher, M; Seitz, B; Speckner, T; Takabayashi, N; Tamas, G; Thomas, A; Van De Vyver, R; Wakai, A; Weihofen, W; Wissmann, F; Zapadtka, F; Zeitler, G

2003-01-01

The helicity dependence of the vector(gamma)vector(p)->p eta reaction has been measured for the first time at a center-of-mass angle theta sup * subeta=70 in the photon energy range from 780 MeV to 790 MeV. The experiment, performed at the Mainz microtron MAMI, used a 4 pi-detector system, a circularly polarized, tagged photon beam, and a longitudinally polarized frozen-spin target. The helicity 3/2 cross-section is found to be small and the results for helicity 1/2 agree with predictions from the MAID analysis. (orig.)

A Semisupervised Support Vector Machines Algorithm for BCI Systems

Science.gov (United States)

Qin, Jianzhao; Li, Yuanqing; Sun, Wei

2007-01-01

As an emerging technology, brain-computer interfaces (BCIs) bring us new communication interfaces which translate brain activities into control signals for devices like computers, robots, and so forth. In this study, we propose a semisupervised support vector machine (SVM) algorithm for brain-computer interface (BCI) systems, aiming at reducing the time-consuming training process. In this algorithm, we apply a semisupervised SVM for translating the features extracted from the electrical recordings of brain into control signals. This SVM classifier is built from a small labeled data set and a large unlabeled data set. Meanwhile, to reduce the time for training semisupervised SVM, we propose a batch-mode incremental learning method, which can also be easily applied to the online BCI systems. Additionally, it is suggested in many studies that common spatial pattern (CSP) is very effective in discriminating two different brain states. However, CSP needs a sufficient labeled data set. In order to overcome the drawback of CSP, we suggest a two-stage feature extraction method for the semisupervised learning algorithm. We apply our algorithm to two BCI experimental data sets. The offline data analysis results demonstrate the effectiveness of our algorithm. PMID:18368141

Vectorization of nuclear codes 90-1

International Nuclear Information System (INIS)

Nonomiya, Iwao; Nemoto, Toshiyuki; Ishiguro, Misako; Harada, Hiroo; Hori, Takeo.

1990-09-01

The vectorization has been made for four codes: SONATINA-2V HTTR version, TRIDOSE, VIENUS, and SCRYU. SONATINA-2V HTTR version is a code for analyzing the dynamic behavior of fuel blocks in the vertical slice of the HTGR (High Temperature Gas-cooled Reactor) core under seismic perturbation, TRIDOSE is a code for calculating environmental tritium concentration and dose, VIENUS is a code for analyzing visco elastic stress of the fuel block of HTTR (High Temperature gas-cooled Test Reactor), and SCRYU is a thermal-hydraulics code with boundary fitted coordinate system. The total speedup ratio of the vectorized versions to the original scalar ones is 5.2 for SONATINA-2V HTTR version. 5.9 ∼ 6.9 for TRIDOSE, 6.7 for VIENUS, 7.6 for SCRYU, respectively. In this report, we describe outline of codes, techniques used for the vectorization, verification of computed results, and speedup effect on the vectorized codes. (author)

Plasmid Vectors for Xylella fastidiosa Utilizing a Toxin-Antitoxin System for Stability in the Absence of Antibiotic Selection.

Science.gov (United States)

Burbank, Lindsey P; Stenger, Drake C

2016-08-01

The phytopathogen Xylella fastidiosa causes disease in a variety of important crop and landscape plants. Functional genetic studies have led to a broader understanding of virulence mechanisms used by this pathogen in the grapevine host. Plasmid shuttle vectors are important tools in studies of bacterial genetics but there are only a limited number of plasmid vectors available that replicate in X. fastidiosa, and even fewer that are retained without antibiotic selection. Two plasmids are described here that show stable replication in X. fastidiosa and are effective for gene complementation both in vitro and in planta. Plasmid maintenance is facilitated by incorporation of the PemI/PemK plasmid addiction system, consisting of PemK, an endoribonuclease toxin, and its cognate antitoxin, PemI. Vector pXf20pemIK utilizes a native X. fastidiosa replication origin as well as a high-copy-number pUC origin for propagation in Escherichia coli cloning strains. Broad-host-range vector pBBR5pemIK is a medium- to low-copy-number plasmid based on the pBBR1 backbone. Both plasmids are maintained for extended periods of time in the absence of antibiotic selection, as well as up to 14 weeks in grapevine, without affecting bacterial fitness. These plasmids present an alternative to traditional complementation and expression vectors which rely on antibiotic selection for plasmid retention.

Classification of polynomial integrable systems of mixed scalar and vector evolution equations: I

International Nuclear Information System (INIS)

Tsuchida, Takayuki; Wolf, Thomas

2005-01-01

We perform a classification of integrable systems of mixed scalar and vector evolution equations with respect to higher symmetries. We consider polynomial systems that are homogeneous under a suitable weighting of variables. This paper deals with the KdV weighting, the Burgers (or potential KdV or modified KdV) weighting, the Ibragimov-Shabat weighting and two unfamiliar weightings. The case of other weightings will be studied in a subsequent paper. Making an ansatz for undetermined coefficients and using a computer package for solving bilinear algebraic systems, we give the complete lists of second-order systems with a third-order or a fourth-order symmetry and third-order systems with a fifth-order symmetry. For all but a few systems in the lists, we show that the system (or, at least a subsystem of it) admits either a Lax representation or a linearizing transformation. A thorough comparison with recent work of Foursov and Olver is made

Classification of polynomial integrable systems of mixed scalar and vector evolution equations: I

Energy Technology Data Exchange (ETDEWEB)

Tsuchida, Takayuki [Department of Physics, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337 (Japan); Wolf, Thomas [Department of Mathematics, Brock University, St Catharines, ON L2S 3A1 (Canada)

2005-09-02

We perform a classification of integrable systems of mixed scalar and vector evolution equations with respect to higher symmetries. We consider polynomial systems that are homogeneous under a suitable weighting of variables. This paper deals with the KdV weighting, the Burgers (or potential KdV or modified KdV) weighting, the Ibragimov-Shabat weighting and two unfamiliar weightings. The case of other weightings will be studied in a subsequent paper. Making an ansatz for undetermined coefficients and using a computer package for solving bilinear algebraic systems, we give the complete lists of second-order systems with a third-order or a fourth-order symmetry and third-order systems with a fifth-order symmetry. For all but a few systems in the lists, we show that the system (or, at least a subsystem of it) admits either a Lax representation or a linearizing transformation. A thorough comparison with recent work of Foursov and Olver is made.

Introduction to matrices and vectors

CERN Document Server

Schwartz, Jacob T

2001-01-01

In this concise undergraduate text, the first three chapters present the basics of matrices - in later chapters the author shows how to use vectors and matrices to solve systems of linear equations. 1961 edition.

Versatile generation of optical vector fields and vector beams using a non-interferometric approach.

Science.gov (United States)

Tripathi, Santosh; Toussaint, Kimani C

2012-05-07

We present a versatile, non-interferometric method for generating vector fields and vector beams which can produce all the states of polarization represented on a higher-order Poincaré sphere. The versatility and non-interferometric nature of this method is expected to enable exploration of various exotic properties of vector fields and vector beams. To illustrate this, we study the propagation properties of some vector fields and find that, in general, propagation alters both their intensity and polarization distribution, and more interestingly, converts some vector fields into vector beams. In the article, we also suggest a modified Jones vector formalism to represent vector fields and vector beams.

A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome.

Science.gov (United States)

Suzuki, Teruhiko; Kazuki, Yasuhiro; Oshimura, Mitsuo; Hara, Takahiko

2014-01-01

Human artificial chromosomes (HACs) are gene-delivery vectors suitable for introducing large DNA fragments into mammalian cells. Although a HAC theoretically incorporates multiple gene expression cassettes of unlimited DNA size, its application has been limited because the conventional gene-loading system accepts only one gene-loading vector (GLV) into a HAC. We report a novel method for the simultaneous or sequential integration of multiple GLVs into a HAC vector (designated as the SIM system) via combined usage of Cre, FLP, Bxb1, and φC31 recombinase/integrase. As a proof of principle, we first attempted simultaneous integration of three GLVs encoding EGFP, Venus, and TdTomato into a gene-loading site of a HAC in CHO cells. These cells successfully expressed all three fluorescent proteins. Furthermore, microcell-mediated transfer of HACs enabled the expression of those fluorescent proteins in recipient cells. We next demonstrated that GLVs could be introduced into a HAC one-by-one via reciprocal usage of recombinase/integrase. Lastly, we introduced a fourth GLV into a HAC after simultaneous integration of three GLVs by FLP-mediated DNA recombination. The SIM system expands the applicability of HAC vectors and is useful for various biomedical studies, including cell reprogramming.

A novel system for simultaneous or sequential integration of multiple gene-loading vectors into a defined site of a human artificial chromosome.

Directory of Open Access Journals (Sweden)

Teruhiko Suzuki

Full Text Available Human artificial chromosomes (HACs are gene-delivery vectors suitable for introducing large DNA fragments into mammalian cells. Although a HAC theoretically incorporates multiple gene expression cassettes of unlimited DNA size, its application has been limited because the conventional gene-loading system accepts only one gene-loading vector (GLV into a HAC. We report a novel method for the simultaneous or sequential integration of multiple GLVs into a HAC vector (designated as the SIM system via combined usage of Cre, FLP, Bxb1, and φC31 recombinase/integrase. As a proof of principle, we first attempted simultaneous integration of three GLVs encoding EGFP, Venus, and TdTomato into a gene-loading site of a HAC in CHO cells. These cells successfully expressed all three fluorescent proteins. Furthermore, microcell-mediated transfer of HACs enabled the expression of those fluorescent proteins in recipient cells. We next demonstrated that GLVs could be introduced into a HAC one-by-one via reciprocal usage of recombinase/integrase. Lastly, we introduced a fourth GLV into a HAC after simultaneous integration of three GLVs by FLP-mediated DNA recombination. The SIM system expands the applicability of HAC vectors and is useful for various biomedical studies, including cell reprogramming.

Engineering BioBrick vectors from BioBrick parts

Directory of Open Access Journals (Sweden)

Knight Thomas F

2008-04-01

Full Text Available Abstract Background The underlying goal of synthetic biology is to make the process of engineering biological systems easier. Recent work has focused on defining and developing standard biological parts. The technical standard that has gained the most traction in the synthetic biology community is the BioBrick standard for physical composition of genetic parts. Parts that conform to the BioBrick assembly standard are BioBrick standard biological parts. To date, over 2,000 BioBrick parts have been contributed to, and are available from, the Registry of Standard Biological Parts. Results Here we extended the same advantages of BioBrick standard biological parts to the plasmid-based vectors that are used to provide and propagate BioBrick parts. We developed a process for engineering BioBrick vectors from BioBrick parts. We designed a new set of BioBrick parts that encode many useful vector functions. We combined the new parts to make a BioBrick base vector that facilitates BioBrick vector construction. We demonstrated the utility of the process by constructing seven new BioBrick vectors. We also successfully used the resulting vectors to assemble and propagate other BioBrick standard biological parts. Conclusion We extended the principles of part reuse and standardization to BioBrick vectors. As a result, myriad new BioBrick vectors can be readily produced from all existing and newly designed BioBrick parts. We invite the synthetic biology community to (1 use the process to make and share new BioBrick vectors; (2 expand the current collection of BioBrick vector parts; and (3 characterize and improve the available collection of BioBrick vector parts.

Vector and Raster Data Storage Based on Morton Code

Science.gov (United States)

Zhou, G.; Pan, Q.; Yue, T.; Wang, Q.; Sha, H.; Huang, S.; Liu, X.

2018-05-01

Even though geomatique is so developed nowadays, the integration of spatial data in vector and raster formats is still a very tricky problem in geographic information system environment. And there is still not a proper way to solve the problem. This article proposes a method to interpret vector data and raster data. In this paper, we saved the image data and building vector data of Guilin University of Technology to Oracle database. Then we use ADO interface to connect database to Visual C++ and convert row and column numbers of raster data and X Y of vector data to Morton code in Visual C++ environment. This method stores vector and raster data to Oracle Database and uses Morton code instead of row and column and X Y to mark the position information of vector and raster data. Using Morton code to mark geographic information enables storage of data make full use of storage space, simultaneous analysis of vector and raster data more efficient and visualization of vector and raster more intuitive. This method is very helpful for some situations that need to analyse or display vector data and raster data at the same time.

Vectorized Monte Carlo

International Nuclear Information System (INIS)

Brown, F.B.

1981-01-01

Examination of the global algorithms and local kernels of conventional general-purpose Monte Carlo codes shows that multigroup Monte Carlo methods have sufficient structure to permit efficient vectorization. A structured multigroup Monte Carlo algorithm for vector computers is developed in which many particle events are treated at once on a cell-by-cell basis. Vectorization of kernels for tracking and variance reduction is described, and a new method for discrete sampling is developed to facilitate the vectorization of collision analysis. To demonstrate the potential of the new method, a vectorized Monte Carlo code for multigroup radiation transport analysis was developed. This code incorporates many features of conventional general-purpose production codes, including general geometry, splitting and Russian roulette, survival biasing, variance estimation via batching, a number of cutoffs, and generalized tallies of collision, tracklength, and surface crossing estimators with response functions. Predictions of vectorized performance characteristics for the CYBER-205 were made using emulated coding and a dynamic model of vector instruction timing. Computation rates were examined for a variety of test problems to determine sensitivities to batch size and vector lengths. Significant speedups are predicted for even a few hundred particles per batch, and asymptotic speedups by about 40 over equivalent Amdahl 470V/8 scalar codes arepredicted for a few thousand particles per batch. The principal conclusion is that vectorization of a general-purpose multigroup Monte Carlo code is well worth the significant effort required for stylized coding and major algorithmic changes

Word-level recognition of multifont Arabic text using a feature vector matching approach

Science.gov (United States)

Erlandson, Erik J.; Trenkle, John M.; Vogt, Robert C., III

1996-03-01

Many text recognition systems recognize text imagery at the character level and assemble words from the recognized characters. An alternative approach is to recognize text imagery at the word level, without analyzing individual characters. This approach avoids the problem of individual character segmentation, and can overcome local errors in character recognition. A word-level recognition system for machine-printed Arabic text has been implemented. Arabic is a script language, and is therefore difficult to segment at the character level. Character segmentation has been avoided by recognizing text imagery of complete words. The Arabic recognition system computes a vector of image-morphological features on a query word image. This vector is matched against a precomputed database of vectors from a lexicon of Arabic words. Vectors from the database with the highest match score are returned as hypotheses for the unknown image. Several feature vectors may be stored for each word in the database. Database feature vectors generated using multiple fonts and noise models allow the system to be tuned to its input stream. Used in conjunction with database pruning techniques, this Arabic recognition system has obtained promising word recognition rates on low-quality multifont text imagery.

VEST: Abstract vector calculus simplification in Mathematica

Science.gov (United States)

Squire, J.; Burby, J.; Qin, H.

2014-01-01

We present a new package, VEST (Vector Einstein Summation Tools), that performs abstract vector calculus computations in Mathematica. Through the use of index notation, VEST is able to reduce three-dimensional scalar and vector expressions of a very general type to a well defined standard form. In addition, utilizing properties of the Levi-Civita symbol, the program can derive types of multi-term vector identities that are not recognized by reduction, subsequently applying these to simplify large expressions. In a companion paper Burby et al. (2013) [12], we employ VEST in the automation of the calculation of high-order Lagrangians for the single particle guiding center system in plasma physics, a computation which illustrates its ability to handle very large expressions. VEST has been designed to be simple and intuitive to use, both for basic checking of work and more involved computations.

Vector Network Coding

OpenAIRE

Ebrahimi, Javad; Fragouli, Christina

2010-01-01

We develop new algebraic algorithms for scalar and vector network coding. In vector network coding, the source multicasts information by transmitting vectors of length L, while intermediate nodes process and combine their incoming packets by multiplying them with L X L coding matrices that play a similar role as coding coefficients in scalar coding. Our algorithms for scalar network jointly optimize the employed field size while selecting the coding coefficients. Similarly, for vector co...

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9.

Directory of Open Access Journals (Sweden)

Kazuhisa Honma

Full Text Available Mouse artificial chromosome (MAC vectors have several advantages as gene delivery vectors, such as stable and independent maintenance in host cells without integration, transferability from donor cells to recipient cells via microcell-mediated chromosome transfer (MMCT, and the potential for loading a megabase-sized DNA fragment. Previously, a MAC containing a multi-integrase platform (MI-MAC was developed to facilitate the transfer of multiple genes into desired cells. Although the MI system can theoretically hold five gene-loading vectors (GLVs, there are a limited number of drugs available for the selection of multiple-GLV integration. To overcome this issue, we attempted to knock out and reuse drug resistance genes (DRGs using the CRISPR-Cas9 system. In this study, we developed new methods for multiple-GLV integration. As a proof of concept, we introduced five GLVs in the MI-MAC by these methods, in which each GLV contained a gene encoding a fluorescent or luminescent protein (EGFP, mCherry, BFP, Eluc, and Cluc. Genes of interest (GOI on the MI-MAC were expressed stably and functionally without silencing in the host cells. Furthermore, the MI-MAC carrying five GLVs was transferred to other cells by MMCT, and the resultant recipient cells exhibited all five fluorescence/luminescence signals. Thus, the MI-MAC was successfully used as a multiple-GLV integration vector using the CRISPR-Cas9 system. The MI-MAC employing these methods may resolve bottlenecks in developing multiple-gene humanized models, multiple-gene monitoring models, disease models, reprogramming, and inducible gene expression systems.

Robust and accurate vectorization of line drawings.

Science.gov (United States)

Hilaire, Xavier; Tombre, Karl

2006-06-01

This paper presents a method for vectorizing the graphical parts of paper-based line drawings. The method consists of separating the input binary image into layers of homogeneous thickness, skeletonizing each layer, segmenting the skeleton by a method based on random sampling, and simplifying the result. The segmentation method is robust with a best bound of 50 percent noise reached for indefinitely long primitives. Accurate estimation of the recognized vector's parameters is enabled by explicitly computing their feasibility domains. Theoretical performance analysis and expression of the complexity of the segmentation method are derived. Experimental results and comparisons with other vectorization systems are also provided.

Design development of the Apollo command and service module thrust vector attitude control systems

Science.gov (United States)

Peters, W. H.

1978-01-01

Development of the Apollo thrust vector control digital autopilot (TVC DAP) was summarized. This is the control system that provided pitch and yaw attitude control during velocity change maneuvers using the main rocket engine on the Apollo service module. A list of ten primary functional requirements for this control system are presented, each being subordinate to a more general requirement appearing earlier on the list. Development process functions were then identified and the essential information flow paths were explored. This provided some visibility into the particular NASA/contractor interface, as well as relationships between the many individual activities.

The economic competitiveness and emissions of battery electric vehicles in China

International Nuclear Information System (INIS)

Zhao, Xin; Doering, Otto C.; Tyner, Wallace E.

2015-01-01

Highlights: • We evaluate the life-cycle cost and emissions of BEVs in China. • BEVs are not economically competitive compared with ICEVs in the Chinese market. • The value of emission reductions is small compared with the subsidy on BEVs. • The CO 2 emission reduction from BEVs is relatively constant over the time. • BEVs likely will not be economically competitive in China before 2031. - Abstract: Electric vehicles (EVs) have high energy efficiency and low pollutant and greenhouse gas (GHG) emissions compared with conventional internal combustion engine vehicles (ICEVs). This study examines the economic competitiveness of battery electric vehicles (BEVs) in the Chinese market. BEVs are compared with ICEVs using benefit-cost analyses from the perspectives of consumers, society and GHG emissions. A life-cycle cost model is developed to evaluate the lifetime cost of a vehicle. The results show that, with central government subsidies, the BEV life-cycle private cost (LCPC) is about 1.4 times higher than comparable ICEVs. Central government subsidies on BEVs will not be cost effective and efficient unless the annual external cost reduction from using BEV reaches $2500 for a compact vehicle or $3600 for a multi-purpose vehicle. That total cost level would imply a carbon cost of more than $2100 per ton. The current life-cycle external cost reductions from using BEV are around $2000–$2300, which are smaller than government subsidies or LCPC differences between BEV and ICEV. Further projections show that BEVs likely will not be economically competitive in the Chinese market before 2031

Biased motion vector interpolation for reduced video artifacts.

NARCIS (Netherlands)

2011-01-01

In a video processing system where motion vectors are estimated for a subset of the blocks of data forming a video frame, and motion vectors are interpolated for the remainder of the blocks of the frame, a method includes determining, for at least at least one block of the current frame for which a

Vector independent transmission of the vector-borne bluetongue virus.

Science.gov (United States)

van der Sluijs, Mirjam Tineke Willemijn; de Smit, Abraham J; Moormann, Rob J M

2016-01-01

Bluetongue is an economically important disease of ruminants. The causative agent, Bluetongue virus (BTV), is mainly transmitted by insect vectors. This review focuses on vector-free BTV transmission, and its epizootic and economic consequences. Vector-free transmission can either be vertical, from dam to fetus, or horizontal via direct contract. For several BTV-serotypes, vertical (transplacental) transmission has been described, resulting in severe congenital malformations. Transplacental transmission had been mainly associated with live vaccine strains. Yet, the European BTV-8 strain demonstrated a high incidence of transplacental transmission in natural circumstances. The relevance of transplacental transmission for the epizootiology is considered limited, especially in enzootic areas. However, transplacental transmission can have a substantial economic impact due to the loss of progeny. Inactivated vaccines have demonstrated to prevent transplacental transmission. Vector-free horizontal transmission has also been demonstrated. Since direct horizontal transmission requires close contact of animals, it is considered only relevant for within-farm spreading of BTV. The genetic determinants which enable vector-free transmission are present in virus strains circulating in the field. More research into the genetic changes which enable vector-free transmission is essential to better evaluate the risks associated with outbreaks of new BTV serotypes and to design more appropriate control measures.

Vector field statistical analysis of kinematic and force trajectories.

Science.gov (United States)

Pataky, Todd C; Robinson, Mark A; Vanrenterghem, Jos

2013-09-27

When investigating the dynamics of three-dimensional multi-body biomechanical systems it is often difficult to derive spatiotemporally directed predictions regarding experimentally induced effects. A paradigm of 'non-directed' hypothesis testing has emerged in the literature as a result. Non-directed analyses typically consist of ad hoc scalar extraction, an approach which substantially simplifies the original, highly multivariate datasets (many time points, many vector components). This paper describes a commensurately multivariate method as an alternative to scalar extraction. The method, called 'statistical parametric mapping' (SPM), uses random field theory to objectively identify field regions which co-vary significantly with the experimental design. We compared SPM to scalar extraction by re-analyzing three publicly available datasets: 3D knee kinematics, a ten-muscle force system, and 3D ground reaction forces. Scalar extraction was found to bias the analyses of all three datasets by failing to consider sufficient portions of the dataset, and/or by failing to consider covariance amongst vector components. SPM overcame both problems by conducting hypothesis testing at the (massively multivariate) vector trajectory level, with random field corrections simultaneously accounting for temporal correlation and vector covariance. While SPM has been widely demonstrated to be effective for analyzing 3D scalar fields, the current results are the first to demonstrate its effectiveness for 1D vector field analysis. It was concluded that SPM offers a generalized, statistically comprehensive solution to scalar extraction's over-simplification of vector trajectories, thereby making it useful for objectively guiding analyses of complex biomechanical systems. © 2013 Published by Elsevier Ltd. All rights reserved.

Models for discrete-time self-similar vector processes with application to network traffic

Science.gov (United States)

Lee, Seungsin; Rao, Raghuveer M.; Narasimha, Rajesh

2003-07-01

The paper defines self-similarity for vector processes by employing the discrete-time continuous-dilation operation which has successfully been used previously by the authors to define 1-D discrete-time stochastic self-similar processes. To define self-similarity of vector processes, it is required to consider the cross-correlation functions between different 1-D processes as well as the autocorrelation function of each constituent 1-D process in it. System models to synthesize self-similar vector processes are constructed based on the definition. With these systems, it is possible to generate self-similar vector processes from white noise inputs. An important aspect of the proposed models is that they can be used to synthesize various types of self-similar vector processes by choosing proper parameters. Additionally, the paper presents evidence of vector self-similarity in two-channel wireless LAN data and applies the aforementioned systems to simulate the corresponding network traffic traces.

Cradle-to-Gate Emissions from a Commercial Electric Vehicle Li-Ion Battery: A Comparative Analysis.

Science.gov (United States)

Kim, Hyung Chul; Wallington, Timothy J; Arsenault, Renata; Bae, Chulheung; Ahn, Suckwon; Lee, Jaeran

2016-07-19

We report the first cradle-to-gate emissions assessment for a mass-produced battery in a commercial battery electric vehicle (BEV); the lithium-ion battery pack used in the Ford Focus BEV. The assessment was based on the bill of materials and primary data from the battery industry, that is, energy and materials input data from the battery cell and pack supplier. Cradle-to-gate greenhouse gas (GHG) emissions for the 24 kWh Ford Focus lithium-ion battery are 3.4 metric tonnes of CO2-eq (140 kg CO2-eq per kWh or 11 kg CO2-eq per kg of battery). Cell manufacturing is the key contributor accounting for 45% of the GHG emissions. We review published studies of GHG emissions associated with battery production to compare and contrast with our results. Extending the system boundary to include the entire vehicle we estimate a 39% increase in the cradle-to-gate GHG emissions of the Focus BEV compared to the Focus internal combustion engine vehicle (ICEV), which falls within the range of literature estimates of 27-63% increases for hypothetical nonproduction BEVs. Our results reduce the uncertainties associated with assessment of BEV battery production, serve to identify opportunities to reduce emissions, and confirm previous assessments that BEVs have great potential to reduce GHG emissions over the full life cycle and provide local emission free mobility.

VectorBase

Data.gov (United States)

U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

Vector boson excitations near deconfined quantum critical points.

Science.gov (United States)

Huh, Yejin; Strack, Philipp; Sachdev, Subir

2013-10-18

We show that the Néel states of two-dimensional antiferromagnets have low energy vector boson excitations in the vicinity of deconfined quantum critical points. We compute the universal damping of these excitations arising from spin-wave emission. Detection of such a vector boson will demonstrate the existence of emergent topological gauge excitations in a quantum spin system.

Custodial vector model

DEFF Research Database (Denmark)

Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan

2015-01-01

We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...

Comparison of 2D and 3D modeled tumor motion estimation/prediction for dynamic tumor tracking during arc radiotherapy

Science.gov (United States)

Liu, Wu; Ma, Xiangyu; Yan, Huagang; Chen, Zhe; Nath, Ravinder; Li, Haiyun

2017-05-01

Many real-time imaging techniques have been developed to localize a target in 3D space or in a 2D beam’s eye view (BEV) plane for intrafraction motion tracking in radiation therapy. With tracking system latency, the 3D-modeled method is expected to be more accurate even in terms of 2D BEV tracking error. No quantitative analysis, however, has been reported. In this study, we simulated co-planar arc deliveries using respiratory motion data acquired from 42 patients to quantitatively compare the accuracy between 2D BEV and 3D-modeled tracking in arc therapy and to determine whether 3D information is needed for motion tracking. We used our previously developed low kV dose adaptive MV-kV imaging and motion compensation framework as a representative of 3D-modeled methods. It optimizes the balance between additional kV imaging dose and 3D tracking accuracy and solves the MLC blockage issue. With simulated Gaussian marker detection errors (zero mean and 0.39 mm standard deviation) and ~155/310/460 ms tracking system latencies, the mean percentage of time that the target moved  >2 mm from the predicted 2D BEV position are 1.1%/4.0%/7.8% and 1.3%/5.8%/11.6% for the 3D-modeled and 2D-only tracking, respectively. The corresponding average BEV RMS errors are 0.67/0.90/1.13 mm and 0.79/1.10/1.37 mm. Compared to the 2D method, the 3D method reduced the average RMS unresolved motion along the beam direction from ~3 mm to ~1 mm, resulting in on average only  <1% dosimetric advantage in the depth direction. Only for a small fraction of the patients, when tracking latency is long, the 3D-modeled method showed significant improvement of BEV tracking accuracy, indicating potential dosimetric advantage. However, if the tracking latency is short (~150 ms or less), those improvements are limited. Therefore, 2D BEV tracking has sufficient targeting accuracy for most clinical cases. The 3D technique is, however, still important in solving the MLC blockage problem

Anticoagulant therapy for venous thromboembolism detected by Doppler ultrasound in patients with metastatic colorectal cancer receiving bevacizumab

Directory of Open Access Journals (Sweden)

Suenaga M

2015-01-01

Full Text Available Mitsukuni Suenaga, Nobuyuki Mizunuma, Eiji Shinozaki, Satoshi Matsusaka, Masato Ozaka, Mariko Ogura, Keisho Chin, Toshiharu Yamaguchi Department of Gastroenterology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan Background: Doppler ultrasound imaging is useful for management of venous thromboembolism associated with a subclavicular implantable central venous access system in patients receiving bevacizumab (Bev. We investigated the efficacy and safety of our anticoagulant regimen based on Doppler findings.Methods: Patients aged ≤75 years with metastatic colorectal cancer, no history of thromboembolism, and no prior use of Bev received chemotherapy plus Bev. Doppler ultrasound imaging of the deep venous system to detect thrombosis was performed after the first course of Bev and repeated after the third course in patients with asymptomatic thrombosis. Indications for anticoagulant therapy in patients with asymptomatic thrombosis were as follows: enlarging thrombus (E, thrombus >40 mm in diameter (S, thrombus involving the superior vena cava (C, and decreased blood flow (V.Results: Among 79 patients enrolled in this study, asymptomatic thrombosis was detected in 56 patients (70.9% by Doppler ultrasound imaging after the first course of Bev and there was no thrombus in 23 patients (29.1%. Of these 56 patients, 11 (19.6% received anticoagulant therapy with warfarin, including eight after the first course and three after follow-up imaging. S + V was observed in four of 11 patients (36.4%, as well as V in two (18.2%, S + V + C in one (9.1%, E + S + V in one (9.1%, E + C in one (9.1%, E in one (9.1%, and C in one (9.1%. All patients resumed chemotherapy, including seven who resumed Bev. Improvement or stabilization of thrombi was achieved in ten patients (90.9%. Only one patient had symptomatic thromboembolism. Mild bleeding due to anticoagulant therapy occurred in six patients (54.5%, but there were no treatment

Learn the Lagrangian: A Vector-Valued RKHS Approach to Identifying Lagrangian Systems.

Science.gov (United States)

Cheng, Ching-An; Huang, Han-Pang

2016-12-01

We study the modeling of Lagrangian systems with multiple degrees of freedom. Based on system dynamics, canonical parametric models require ad hoc derivations and sometimes simplification for a computable solution; on the other hand, due to the lack of prior knowledge in the system's structure, modern nonparametric models in machine learning face the curse of dimensionality, especially in learning large systems. In this paper, we bridge this gap by unifying the theories of Lagrangian systems and vector-valued reproducing kernel Hilbert space. We reformulate Lagrangian systems with kernels that embed the governing Euler-Lagrange equation-the Lagrangian kernels-and show that these kernels span a subspace capturing the Lagrangian's projection as inverse dynamics. By such property, our model uses only inputs and outputs as in machine learning and inherits the structured form as in system dynamics, thereby removing the need for the mundane derivations for new systems as well as the generalization problem in learning from scratches. In effect, it learns the system's Lagrangian, a simpler task than directly learning the dynamics. To demonstrate, we applied the proposed kernel to identify the robot inverse dynamics in simulations and experiments. Our results present a competitive novel approach to identifying Lagrangian systems, despite using only inputs and outputs.

Experimental demonstration of vector E x vector B plasma divertor

International Nuclear Information System (INIS)

Strait, E.J.; Kerst, D.W.; Sprott, J.C.

1977-01-01

The vector E x vector B drift due to an applied radial electric field in a tokamak with poloidal divertor can speed the flow of plasma out of the scrape-off region, and provide a means of externally controlling the flow rate and thus the width of the density fall-off. An experiment in the Wisconsin levitated toroidal octupole, using vector E x vector B drifts alone, demonstrates divertor-like behavior, including 70% reduction of plasma density near the wall and 40% reduction of plasma flux to the wall, with no adverse effects on confinement of the main plasma

MTR-18 Predictive Biomarkers Of Bevacizumab Response In Recurrent Glioblastoma Patients

DEFF Research Database (Denmark)

Urup, Thomas; Michaelsen, Signe Regner; Olsen, Lars Rønn

2015-01-01

Bevacizumab (BEV) plus chemotherapy has shown activity in recurrent glioblastoma (GBM). However, the prognosis varies and only one third of patients have a durable clinical response to BEV combination therapy. Recent findings from a randomized phase-3 study (AVAglio) indicate that patients...... with the proneural GBM subtype have a survival benefit when treated with BEV in combination with standard treatment. However, no validated biomarkers able to predict BEV response have been identified and the biology reflecting a clinical BEV response is poorly understood. The primary objective of this study...... was to evaluate the predictive and prognostic value of GBM subtypes in recurrent GBM patients treated with BEV therapy. The secondary objective was to identify biomarkers able to predict response to BEV therapy in recurrent GBM patients. METHODS: A total of 90 recurrent GBM patients treated with BEV combination...

Speaker Recognition from Emotional Speech Using I-vector Approach

Directory of Open Access Journals (Sweden)

MACKOVÁ Lenka

2014-05-01

Full Text Available In recent years the concept of i-vectors become very popular and successful in the field of the speaker verification. The basic principle of i-vectors is that each utterance is represented by fixed-length feature vector of low-dimension. In the literature for purpose of speaker verification various recordings obtained from telephones or microphones were used. The aim of this experiment was to perform speaker verification using speaker model trained with emotional recordings on i-vector basis. The Mel Frequency Cepstral Coefficients (MFCC, log energy, their deltas and acceleration coefficients were used in process of features extraction. As the classification methods of the verification system Mahalanobis distance metric in combination with Eigen Factor Radial normalization was used and in the second approach Cosine Distance Scoring (CSS metric with Within-class Covariance Normalization as a channel compensation was employed. This verification system used emotional recordings of male subjects from freely available German emotional database (Emo-DB.

Rotations with Rodrigues' vector

International Nuclear Information System (INIS)

Pina, E

2011-01-01

The rotational dynamics was studied from the point of view of Rodrigues' vector. This vector is defined here by its connection with other forms of parametrization of the rotation matrix. The rotation matrix was expressed in terms of this vector. The angular velocity was computed using the components of Rodrigues' vector as coordinates. It appears to be a fundamental matrix that is used to express the components of the angular velocity, the rotation matrix and the angular momentum vector. The Hamiltonian formalism of rotational dynamics in terms of this vector uses the same matrix. The quantization of the rotational dynamics is performed with simple rules if one uses Rodrigues' vector and similar formal expressions for the quantum operators that mimic the Hamiltonian classical dynamics.

Violation of vector dominance in the vector manifestation

International Nuclear Information System (INIS)

Sasaki, Chihiro

2003-01-01

The vector manifestation (VM) is a new pattern for realizing the chiral symmetry in QCD. In the VM, the massless vector meson becomes the chiral partner of pion at the critical point, in contrast with the restoration based on the linear sigma model. Including the intrinsic temperature dependences of the parameters of the hidden local symmetry (HLS) Lagrangian determined from the underlying QCD through the Wilsonian matching together with the hadronic thermal corrections, we present a new prediction of the VM on the direct photon-π-π coupling which measures the validity of the vector dominance (VD) of the electromagnetic form factor of the pion. We find that the VD is largely violated at the critical temperature, which indicates that the assumption of the VD made in several analysis on the dilepton spectra in hot matter may need to be weakened for consistently including the effect of the dropping mass of the vector meson. (author)

Generation of arbitrary vector beams with liquid crystal polarization converters and vector-photoaligned q-plates

International Nuclear Information System (INIS)

Chen, Peng; Ji, Wei; Wei, Bing-Yan; Hu, Wei; Lu, Yan-Qing; Chigrinov, Vladimir

2015-01-01

Arbitrary vector beams (VBs) are realized by the designed polarization converters and corresponding vector-photoaligned q-plates. The polarization converter is a specific twisted nematic cell with one substrate homogeneously aligned and the other space-variantly aligned. By combining a polarization-sensitive alignment agent with a dynamic micro-lithography system, various categories of liquid crystal polarization converters are demonstrated. Besides, traditional radially/azimuthally polarized light, high-order and multi-ringed VBs, and a VB array with different orders are generated. The obtained converters are further utilized as polarization masks to implement vector-photoaligning. The technique facilitates both the volume duplication of these converters and the generation of another promising optical element, the q-plate, which is suitable for the generation of VBs for coherent lasers. The combination of proposed polarization converters and correspondingly fabricated q-plates would drastically enhance the capability of polarization control and may bring more possibilities for the design of photonic devices

A novel recombinant virus-like particle vaccine for prevention of porcine parvovirus-induced reproductive failure.

Science.gov (United States)

Antonis, Adriaan F G; Bruschke, Christianne J M; Rueda, Paloma; Maranga, Luis; Casal, J Ignacio; Vela, Carmen; Hilgers, Luuk A Th; Belt, Peter B G M; Weerdmeester, Klaas; Carrondo, Manuel J T; Langeveld, Jan P M

2006-06-29

A novel vaccine against porcine parvovirus (PPV), composed of recombinant virus-like particles (PPV-VLPs) produced with the baculovirus expression vector system (BEVS) at industrial scale, was tested for its immunogenicity and protective potency. A formulation of submicrogram amounts of PPV-VLPs in a water-in-mineral oil adjuvant evoked high serum antibody titres in both guinea pigs, used as reference model, and target species, pigs. A single immunisation with 0.7microg of this antigen yielded complete foetal protection against PPV infection after challenge with a virulent strain of this virus. Furthermore, also in the presence of mild adjuvants the protective action of these PPV-VLPs is excellent. This recombinant subunit vaccine overcomes some of the drawbacks of classical PPV vaccines.

Arthropod Innate Immune Systems and Vector-Borne Diseases.

Science.gov (United States)

Baxter, Richard H G; Contet, Alicia; Krueger, Kathryn

2017-02-21

Arthropods, especially ticks and mosquitoes, are the vectors for a number of parasitic and viral human diseases, including malaria, sleeping sickness, Dengue, and Zika, yet arthropods show tremendous individual variation in their capacity to transmit disease. A key factor in this capacity is the group of genetically encoded immune factors that counteract infection by the pathogen. Arthropod-specific pattern recognition receptors and protease cascades detect and respond to infection. Proteins such as antimicrobial peptides, thioester-containing proteins, and transglutaminases effect responses such as lysis, phagocytosis, melanization, and agglutination. Effector responses are initiated by damage signals such as reactive oxygen species signaling from epithelial cells and recognized by cell surface receptors on hemocytes. Antiviral immunity is primarily mediated by siRNA pathways but coupled with interferon-like signaling, antimicrobial peptides, and thioester-containing proteins. Molecular mechanisms of immunity are closely linked to related traits of longevity and fertility, and arthropods have the capacity for innate immunological memory. Advances in understanding vector immunity can be leveraged to develop novel control strategies for reducing the rate of transmission of both ancient and emerging threats to global health.

Measurement of K/sub NN/, K/sub LL/ in p vector d → n vector X and p vector 9Be → n vector X at 800 MeV

International Nuclear Information System (INIS)

Riley, P.J.; Hollas, C.L.; Newsom, C.R.

1980-01-01

The spin transfer parameters, K/sub NN/ and K/sub LL/, have been measured in p vector d → n vector X and p vector 9 Be → n vector X at 0 0 and 800 MeV. The rather large values of K/sub LL/ demonstrate that this transfer mechanism will provide a useful source of polarized neutrons at LAMPF energies

An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes.

Science.gov (United States)

Kang, W; Wang, L; Harrell, H; Liu, J; Thomas, D L; Mayfield, T L; Scotti, M M; Ye, G J; Veres, G; Knop, D R

2009-02-01

Recombinant herpes simplex virus type 1 (rHSV)-assisted recombinant adeno-associated virus (rAAV) vector production provides a highly efficient and scalable method for manufacture of clinical grade rAAV vectors. Here, we present an rHSV co-infection system for rAAV production, which uses two ICP27-deficient rHSV constructs, one bearing the rep2 and cap (1, 2 or 9) genes of rAAV, and the second bearing an AAV2 ITR-gene of interest (GOI) cassette. The optimum rAAV production parameters were defined by producing rAAV2/GFP in HEK293 cells, yielding greater than 9000 infectious particles per cell with a 14:1 DNase resistance particle to infectious particle (DRP/ip) ratio. The optimized co-infection parameters were then used to generate large-scale stocks of rAAV1/AAT, which encode the human alpha-1-antitrypsin (hAAT) protein, and purified by column chromatography. The purified vector was extensively characterized by rAAV- and rHSV-specific assays and compared to transfection-made vector for in vivo efficacy in mice through intramuscular injection. The co-infection method was also used to produce rAAV9/AAT for comparison to rAAV1/AAT in vivo. Intramuscular administration of 1 x 10(11) DRP per animal of rHSV-produced rAAV1/AAT and rAAV9/AAT resulted in hAAT protein expression of 5.4 x 10(4) and 9.4 x 10(5) ng ml(-1) serum respectively, the latter being clinically relevant.

Real-world Direct Health Care Costs for Metastatic Colorectal Cancer Patients Treated With Cetuximab or Bevacizumab-containing Regimens in First-line or First-line Through Second-line Therapy.

Science.gov (United States)

Johnston, Stephen; Wilson, Kathleen; Varker, Helen; Malangone-Monaco, Elisabetta; Juneau, Paul; Riehle, Ellen; Satram-Hoang, Sacha; Sommer, Nicolas; Ogale, Sarika

2017-12-01

The present study examined real-world direct health care costs for metastatic colorectal cancer (mCRC) patients initiating first-line (1L) bevacizumab (BEV)- or cetuximab (CET)-containing regimen in 1L or 1L-through-second-line (1L-2L) therapy. Using a large US insurance claims database, patients with mCRC initiating 1L BEV- or 1L CET-containing regimen from January 1, 2008 to September 30, 2014 were identified. The per-patient per-month (PPPM) all-cause health care costs (2014 US dollars) were measured during 1L therapy and, for patients continuing to a 2L biologic-containing regimen, 1L-2L therapy. Multivariable regression analyses were used to compare PPPM total health care costs between patients initiating a 1L BEV- versus 1L CET-containing regimen. A total of 6095 patients initiating a 1L BEV- and 453 initiating a 1L CET-containing regimen were evaluated for 1L costs; 2218 patients initiating a 1L BEV- and 134 initiating a 1L CET-containing regimen were evaluated for 1L-2L costs. In 1L therapy, 1L CET had adjusted PPPM costs that were $3135 (95% confidence interval [CI], $1174-$5040; P < .001) greater on average than 1L BEV. In 1L-2L therapy, 1L BEV-2L CET had adjusted PPPM costs that were $1402 (95% CI, $1365-$1442; P = .010) greater than those for 1L BEV-2L BEV, and 1L CET-2L BEV had adjusted PPPM costs that were $4279 (95% CI, $4167-$4400; P = .001) greater on average than those for 1L BEV-2L BEV. The adjusted PPPM cost differences for 1L BEV-2L other biologic or 1L CET-2L other biologic agent were numerically greater but statistically insignificant. PPPM total health care costs for 1L and 2L therapy tended to be greater for patients treated with 1L CET-containing regimens than for 1L BEV-containing regimens. Also, continuing treatment with BEV-containing regimens 1L-2L was less costly than switching between BEV and CET. The cost differences between BEV and CET hold important implications for treatment decisions of mCRC patients in real-world clinical

Integration of multidisciplinary technologies for real time target visualization and verification for radiotherapy.

Science.gov (United States)

Chang, Wen-Chung; Chen, Chin-Sheng; Tai, Hung-Chi; Liu, Chia-Yuan; Chen, Yu-Jen

2014-01-01

The current practice of radiotherapy examines target coverage solely from digitally reconstructed beam's eye view (BEV) in a way that is indirectly accessible and that is not in real time. We aimed to visualize treatment targets in real time from each BEV. The image data of phantom or patients from ultrasound (US) and computed tomography (CT) scans were captured to perform image registration. We integrated US, CT, US/CT image registration, robotic manipulation of US, a radiation treatment planning system, and a linear accelerator to constitute an innovative target visualization system. The performance of this algorithm segmented the target organ in CT images, transformed and reconstructed US images to match each orientation, and generated image registration in real time mode with acceptable accuracy. This image transformation allowed physicians to visualize the CT image-reconstructed target via a US probe outside the BEV that was non-coplanar to the beam's plane. It allowed the physicians to remotely control the US probe that was equipped on a robotic arm to dynamically trace and real time monitor the coverage of the target within the BEV during a simulated beam-on situation. This target visualization system may provide a direct remotely accessible and real time way to visualize, verify, and ensure tumor targeting during radiotherapy.

Cloud Monitoring for Solar Plants with Support Vector Machine Based Fault Detection System

Directory of Open Access Journals (Sweden)

Hong-Chan Chang

2014-01-01

Full Text Available This study endeavors to develop a cloud monitoring system for solar plants. This system incorporates numerous subsystems, such as a geographic information system, an instantaneous power-consumption information system, a reporting system, and a failure diagnosis system. Visual C# was integrated with ASP.NET and SQL technologies for the proposed monitoring system. A user interface for database management system was developed to enable users to access solar power information and management systems. In addition, by using peer-to-peer (P2P streaming technology and audio/video encoding/decoding technology, real-time video data can be transmitted to the client end, providing instantaneous and direct information. Regarding smart failure diagnosis, the proposed system employs the support vector machine (SVM theory to train failure mathematical models. The solar power data are provided to the SVM for analysis in order to determine the failure types and subsequently eliminate failures at an early stage. The cloud energy-management platform developed in this study not only enhances the management and maintenance efficiency of solar power plants but also increases the market competitiveness of solar power generation and renewable energy.

Factors of electric vehicle adoption: A comparison of conventional and electric car users based on an extended theory of planned behavior

DEFF Research Database (Denmark)

Haustein, Sonja; Jensen, Anders Fjendbo

2018-01-01

and norms than CV users. The different profiles of these user groups suggest a separate analysis of potential factors of BEV adoption in both groups. In regression analyses, CV and BEV users' intention to use/purchase a BEV is modeled based on factors of the Theory of Planned Behavior extended by personal...... distance seems of particular relevance. In multiple car households, we found the percentage of actual BEV usage related to the type of other cars in the household, perceived functional barriers of BEVs as well as (successful) behavioral adaption to longer trips by BEVs. Based on the results, we discuss...

Automated Vectorization of Decision-Based Algorithms

Science.gov (United States)

James, Mark

2006-01-01

Virtually all existing vectorization algorithms are designed to only analyze the numeric properties of an algorithm and distribute those elements across multiple processors. This advances the state of the practice because it is the only known system, at the time of this reporting, that takes high-level statements and analyzes them for their decision properties and converts them to a form that allows them to automatically be executed in parallel. The software takes a high-level source program that describes a complex decision- based condition and rewrites it as a disjunctive set of component Boolean relations that can then be executed in parallel. This is important because parallel architectures are becoming more commonplace in conventional systems and they have always been present in NASA flight systems. This technology allows one to take existing condition-based code and automatically vectorize it so it naturally decomposes across parallel architectures.

First measurement of the helicity-dependent (vector)({gamma})(vector)(p){yields}p{eta} differential cross-section

Energy Technology Data Exchange (ETDEWEB)

Ahrens, J.; Arends, H.J.; Aulenbacher, K.; Beck, R.; Drechsel, D.; Harrach, D. van; Heid, E. [Institut fuer Kernphysik, Universitaet Mainz, D-55099 Mainz (Germany); Altieri, S. [INFN, Sezione di Pavia, I-27100 Pavia (Italy); Dipartimento di Fisica Nucleare e Teorica, Universita di Pavia, I-27100 Pavia (Italy); Annand, J.R.M. [Department of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Anton, G. [Physikalisches Institut, Universitaet Erlangen-Nuernberg, D-91058 Erlangen (Germany); Bradtke, C.; Goertz, S.; Harmsen, J. [Institut fuer Experimentalphysik, Ruhr-Universitaet Bochum, D-44801 Bochum (Germany); Braghieri, A. [INFN, Sezione di Pavia, I-27100 Pavia (Italy); d' Hose, N. [CEA Saclay, DSM/DAPNIA/SPhN, F-91191 Gif-sur-Yvette Cedex (France); Dutz, H. [Physikalisches Institut, Universitaet Bonn, D-53115 Bonn (Germany); Grabmayr, P. [Physikalisches Institut, Universitaet Tuebingen, D-72076 Tuebingen (Germany); Hansen, K. [Department of Physics, University of Lund, Lund (Sweden); Hasegawa, S. [Department of Physics, Nagoya University, Chikusa-ku, Nagoya (Japan); Hasegawa, T. [Faculty of Engineering, Miyazaki University, Miyazaki (Japan); Helbing, K.; Holvoet, H.; Van Hoorebeke, L.; Horikawa, N.; Iwata, T.; Jahn, O.; Jennewein, P.; Kageya, T.; Kiel, B.; Klein, F.; Kondratiev, R.; Kossert, K.; Krimmer, J.; Lang, M.; Lannoy, B.; Leukel, R.; Lisin, V.; Matsuda, T.; McGeorge, J.C.; Meier, A.; Menze, D.; Meyer, W.; Michel, T.; Naumann, J.; Panzeri, A.; Pedroni, P.; Pinelli, T.; Preobrajenski, I.; Radtke, E.; Reichert, E.; Reicherz, G.; Rohlof, Ch.; Rosner, G.; Ryckbosch, D.; Sauer, M.; Schoch, B.; Schumacher, M.; Seitz, B.; Speckner, T.; Takabayashi, N.; Tamas, G.; Thomas, A.; Van de Vyver, R.; Wakai, A.; Weihofen, W.; Wissmann, F.; Zapadtka, F.; Zeitler, G.

2003-06-01

The helicity dependence of the (vector)({gamma})(vector)(p){yields}p{eta} reaction has been measured for the first time at a center-of-mass angle {theta}{sup *}{sub {eta}}=70 in the photon energy range from 780 MeV to 790 MeV. The experiment, performed at the Mainz microtron MAMI, used a 4{pi}-detector system, a circularly polarized, tagged photon beam, and a longitudinally polarized frozen-spin target. The helicity 3/2 cross-section is found to be small and the results for helicity 1/2 agree with predictions from the MAID analysis. (orig.)

Existence and Hadamard well-posedness of a system of simultaneous generalized vector quasi-equilibrium problems

Directory of Open Access Journals (Sweden)

Wenyan Zhang

2017-03-01

Full Text Available Abstract An existence result for the solution set of a system of simultaneous generalized vector quasi-equilibrium problems (for short, (SSGVQEP is obtained, which improves Theorem 3.1 of the work of Ansari et al. (J. Optim. Theory Appl. 127:27-44, 2005. Moreover, a definition of Hadamard-type well-posedness for (SSGVQEP is introduced and sufficient conditions for Hadamard well-posedness of (SSGVQEP are established.

Construction of gateway-compatible yeast two-hybrid vectors for ...

African Journals Online (AJOL)

Yeast two-hybrid system combined with the gateway technology will greatly facilitate the cloning of interested DNA fragment into yeast two-hybrid vectors and therefore increase the efficiency of yeast two-hybrid analysis. In this study, we constructed a pair of Gateway-compatible yeast two-hybrid vectors pBTM116GW and ...

Novel strategy for generation and titration of recombinant adeno-associated virus vectors.

Science.gov (United States)

Shiau, Ai-Li; Liu, Pu-Ste; Wu, Chao-Liang

2005-01-01

Recombinant adeno-associated virus (rAAV) vectors have many advantages for gene therapeutic applications compared with other vector systems. Several methods that use plasmids or helper viruses have been reported for the generation of rAAV vectors. Unfortunately, the preparation of large-scale rAAV stocks is labor-intensive. Moreover, the biological titration of rAAV is still difficult, which may limit its preclinical and clinical applications. For this study, we developed a novel strategy to generate and biologically titrate rAAV vectors. A recombinant pseudorabies virus (PrV) with defects in its gD, gE, and thymidine kinase genes was engineered to express the AAV rep and cap genes, yielding PS virus, which served as a packaging and helper virus for the generation of rAAV vectors. PS virus was useful not only for generating high-titer rAAV vectors by cotransfection with an rAAV vector plasmid, but also for amplifying rAAV stocks. Notably, the biological titration of rAAV vectors was also feasible when cells were coinfected with rAAV and PS virus. Based on this strategy, we produced an rAAV that expresses prothymosin alpha (ProT). Expression of the ProT protein in vitro and in vivo mediated by rAAV/ProT gene transfer was detected by immunohistochemistry and a bioassay. Taken together, our results demonstrate that the PrV vector-based system is useful for generating rAAV vectors carrying various transgenes.

Vector velocimeter

DEFF Research Database (Denmark)

2012-01-01

The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...

Cloning vector

Science.gov (United States)

Guilfoyle, Richard A.; Smith, Lloyd M.

1994-01-01

A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site.

Cloning vector

Science.gov (United States)

Guilfoyle, R.A.; Smith, L.M.

1994-12-27

A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site. 2 figures.

Arthropod Innate Immune Systems and Vector-Borne Diseases

OpenAIRE

Baxter, Richard H. G.; Contet, Alicia; Krueger, Kathryn

2017-01-01

Arthropods, especially ticks and mosquitoes, are the vectors for a number of parasitic and viral human diseases, including malaria, sleeping sickness, Dengue, and Zika, yet arthropods show tremendous individual variation in their capacity to transmit disease. A key factor in this capacity is the group of genetically encoded immune factors that counteract infection by the pathogen. Arthropod-specific pattern recognition receptors and protease cascades detect and respond to infection. Proteins ...

Quantum nonlinear lattices and coherent state vectors

DEFF Research Database (Denmark)

Ellinas, Demosthenes; Johansson, M.; Christiansen, Peter Leth

1999-01-01

for the state vectors invokes the study of the Riemannian and symplectic geometry of the CSV manifolds as generalized phase spaces. Next, we investigate analytically and numerically the behavior of mean values and uncertainties of some physically interesting observables as well as the modifications...... (FP) model. Based on the respective dynamical symmetries of the models, a method is put forward which by use of the associated boson and spin coherent state vectors (CSV) and a factorization ansatz for the solution of the Schrodinger equation, leads to quasiclassical Hamiltonian equations of motion...... state vectors, and accounts for the quantum correlations of the lattice sites that develop during the time evolution of the systems. (C) 1999 Elsevier Science B.V. All rights reserved....

Does this range suit me? Range satisfaction of battery electric vehicle users.

Science.gov (United States)

Franke, Thomas; Günther, Madlen; Trantow, Maria; Krems, Josef F

2017-11-01

User satisfaction is a vital design criterion for sustainable systems. The present research aimed to understand factors relating to individually perceived range satisfaction of battery electric vehicle (BEV) users. Data from a large-scale BEV field trial (N = 72) were analyzed. Apart from an initial drop in range satisfaction, increasing practical experience was related to increased range satisfaction. Classical indicators of users' mobility profiles (daily travel distances) were only weakly related to lower range satisfaction (not significant), after controlling for practical experience and preferred coverage of mobility needs. The regularity/predictability of users' mobility patterns, the percentage of journeys not coverable because of range issues, and users' individual comfortable range accounted for variance in range satisfaction. Finally, range satisfaction was related to key indicators of general BEV acceptance (e.g., purchase intentions). These results underline the complex dynamics involved in individual range satisfaction, as well as its central role for BEV acceptance. Copyright © 2017 Elsevier Ltd. All rights reserved.

A New Waveform Mosaic Algorithm in the Vectorization of Paper Seismograms

Directory of Open Access Journals (Sweden)

Maofa Wang

2014-11-01

Full Text Available History paper seismograms are very important information for earthquake monitoring and prediction, and the vectorization of paper seismograms is a very import problem to be resolved. In this paper, a new waveform mosaic algorithm in the vectorization of paper seismograms is presented. We also give out the technological process to waveform mosaic, and a waveform mosaic system used to vectorize analog seismic record has been accomplished independently. Using it, we can precisely and speedy accomplish waveform mosaic for vectorizing analog seismic records.

Control Instabilities in a Pulsed Multi-Cavity RF System with Vector Sum Feedback (A Mathematical Analysis)

CERN Document Server

Tückmantel, Joachim

2001-01-01

Upcoming projects relying on pulsed linear accelerators intend to use superconducting RF systems. Cost reasons suggest driving several cavities by a common transmitter, controlled over a vector sum feedback system, possibly supported by a feed forward system. Numerical simulations hint that such a system may become uncontrollable under certain conditions. In the present paper, for a model very close to reality, we will present a mathematical proof that in fact spontaneous symmetry braking is possible for these configurations, defining also the precise conditions under which it will take place. These can be used as an estimate for the real RF system stability limits. The listing of a small program demonstrating the mechanism numerically for two cavities is attached.

Extending the length and time scales of Gram–Schmidt Lyapunov vector computations

Energy Technology Data Exchange (ETDEWEB)

Costa, Anthony B., E-mail: acosta@northwestern.edu [Department of Chemistry, Northwestern University, Evanston, IL 60208 (United States); Green, Jason R., E-mail: jason.green@umb.edu [Department of Chemistry, Northwestern University, Evanston, IL 60208 (United States); Department of Chemistry, University of Massachusetts Boston, Boston, MA 02125 (United States)

2013-08-01

Lyapunov vectors have found growing interest recently due to their ability to characterize systems out of thermodynamic equilibrium. The computation of orthogonal Gram–Schmidt vectors requires multiplication and QR decomposition of large matrices, which grow as N{sup 2} (with the particle count). This expense has limited such calculations to relatively small systems and short time scales. Here, we detail two implementations of an algorithm for computing Gram–Schmidt vectors. The first is a distributed-memory message-passing method using Scalapack. The second uses the newly-released MAGMA library for GPUs. We compare the performance of both codes for Lennard–Jones fluids from N=100 to 1300 between Intel Nahalem/Infiniband DDR and NVIDIA C2050 architectures. To our best knowledge, these are the largest systems for which the Gram–Schmidt Lyapunov vectors have been computed, and the first time their calculation has been GPU-accelerated. We conclude that Lyapunov vector calculations can be significantly extended in length and time by leveraging the power of GPU-accelerated linear algebra.

Extending the length and time scales of Gram–Schmidt Lyapunov vector computations

International Nuclear Information System (INIS)

Costa, Anthony B.; Green, Jason R.

2013-01-01

Lyapunov vectors have found growing interest recently due to their ability to characterize systems out of thermodynamic equilibrium. The computation of orthogonal Gram–Schmidt vectors requires multiplication and QR decomposition of large matrices, which grow as N 2 (with the particle count). This expense has limited such calculations to relatively small systems and short time scales. Here, we detail two implementations of an algorithm for computing Gram–Schmidt vectors. The first is a distributed-memory message-passing method using Scalapack. The second uses the newly-released MAGMA library for GPUs. We compare the performance of both codes for Lennard–Jones fluids from N=100 to 1300 between Intel Nahalem/Infiniband DDR and NVIDIA C2050 architectures. To our best knowledge, these are the largest systems for which the Gram–Schmidt Lyapunov vectors have been computed, and the first time their calculation has been GPU-accelerated. We conclude that Lyapunov vector calculations can be significantly extended in length and time by leveraging the power of GPU-accelerated linear algebra

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution?

Directory of Open Access Journals (Sweden)

Anja Ehrhardt

2009-12-01

Full Text Available The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based on these findings major improvements in vector design including the development of viral hybrid vectors for somatic integration have been achieved. This review provides a state-of-the-art overview of available hybrid vectors utilizing viruses for high transduction efficiencies in concert with various integration machineries for random and targeted integration patterns. It discusses advantages but also limitations of each vector system.

Complex vector triads in spinor theory in Minkowski space

International Nuclear Information System (INIS)

Zhelnorovich, V.A.

1990-01-01

It is shown that tensor equations corresponding to the spinor Dirac equations represent a three-dimensional part of four-dimensional vector equations. The equations are formulated in an evidently invariant form in antisymmetric tensor components and in the corresponding components of a complex vector triad. A complete system of relativistically invariant tensor equations is ascertained

Rotation vectors for homeomorphisms of non-positively curved manifolds

International Nuclear Information System (INIS)

Lessa, Pablo

2011-01-01

Rotation vectors, as defined for homeomorphisms of the torus that are isotopic to the identity, are generalized to such homeomorphisms of any complete Riemannian manifold with non-positive sectional curvature. These generalized rotation vectors are shown to exist for almost every orbit of such a dynamical system with respect to any invariant measure with compact support. The concept is then extended to flows and, as an application, it is shown how non-null rotation vectors can be used to construct a measurable semi-conjugacy between a given flow and the geodesic flow of a manifold

Probing deformed orbitals with vector A( vector e, e' N)B reactions

International Nuclear Information System (INIS)

Garrido, E.; Caballero, J.A.; Moya de Guerra, E.; Sarriguren, P.; Udias, J.M.

1995-01-01

We present results for response functions and asymmetries in the nuclear reactions 37 vector Ar( vector e, e' n) 36 Ar and 37 vector K( vector e,e' p) 36 Ar at quasifree kinematics. We compare PWIA results obtained using deformed HF wave functions with PWIA and DWIA results obtained assuming a spherical mean field. We show that the complex structure of the deformed orbitals can be probed by coincidence measurements with polarized beam and targets. ((orig.))

Cost-Effectiveness Analysis of Different Sequences of the Use of Epidermal Growth Factor Receptor Inhibitors for Wild-Type KRAS Unresectable Metastatic Colorectal Cancer.

Science.gov (United States)

Riesco-Martínez, Maria Carmen; Berry, Scott R; Ko, Yoo-Joung; Mittmann, Nicole; Giotis, Angie; Lien, Kelly; Wong, William W L; Chan, Kelvin K W

2016-06-01

Patients with unresectable wild-type KRAS metastatic colorectal cancer benefit from fluoropyrimidines (FP), oxaliplatin (O), irinotecan (I), bevacizumab (Bev), and epithelial growth factor receptor inhibitors (EGFRI). The most cost-effective regimen remains unclear. A Markov model was constructed to examine the costs and outcomes of three treatment strategies: strategy A (reference strategy): EGFRI monotherapy in third line ([3L]; ie, first-line [1L]: Bev + FOLFIRI [FP + I] or FOLFOX [FP + O]; second line [2L]: FOLFIRI/FOLFOX; 3L: EGFRI); strategy B: EGFRI and I in 3L (ie, 1L: Bev + FOLFIRI/FOLFOX; 2L: FOLFIRI/FOLFOX; 3L: EGFRI + I); and strategy C: EGFRI in 1L (ie, 1L: EGFRI + FOLFIRI/FOLFOX; 2L: Bev + FOLFIRI/FOLFOX; 3L: best supportive care). Efficacy data of the treatments were obtained from the literature. Health system resource use information was derived from chart review and the literature. Using Euro-QOL 5 Dimensions, utilities were obtained by surveying medical oncologists and costs from the Ontario Ministry of Health and the literature. The perspective of the Canadian public health care system was used over a 5-year time horizon with a 5% discount in 2012 Canadian dollars. All three strategies had similar efficacy, but strategy C was most expensive. The incremental cost-effectiveness ratios (ICERs) for strategies B and C compared with A were 119,623 and 3,176,591, respectively. The model was primarily driven by the acquisition cost of the drugs. Strategy B was most cost effective when the willingness-to-pay threshold was > $130,000 per quality-adjusted life-year. Sensitivity analysis showed that strategy C would be cost-effective only when the progression-free survival of EGFRI is better than Bev in 1L with hazard ratio pricing relative to Bev. Copyright © 2016 by American Society of Clinical Oncology.

Molecular design for recombinant adeno-associated virus (rAAV) vector production.

Science.gov (United States)

Aponte-Ubillus, Juan Jose; Barajas, Daniel; Peltier, Joseph; Bardliving, Cameron; Shamlou, Parviz; Gold, Daniel

2018-02-01

Recombinant adeno-associated virus (rAAV) vectors are increasingly popular tools for gene therapy applications. Their non-pathogenic status, low inflammatory potential, availability of viral serotypes with different tissue tropisms, and prospective long-lasting gene expression are important attributes that make rAAVs safe and efficient therapeutic options. Over the last three decades, several groups have engineered recombinant AAV-producing platforms, yielding high titers of transducing vector particles. Current specific productivity yields from different platforms range from 10 3 to 10 5 vector genomes (vg) per cell, and there is an ongoing effort to improve vector yields in order to satisfy high product demands required for clinical trials and future commercialization.Crucial aspects of vector production include the molecular design of the rAAV-producing host cell line along with the design of AAV genes, promoters, and regulatory elements. Appropriately, configuring and balancing the expression of these elements not only contributes toward high productivity, it also improves process robustness and product quality. In this mini-review, the rational design of rAAV-producing expression systems is discussed, with special attention to molecular strategies that contribute to high-yielding, biomanufacturing-amenable rAAV production processes. Details on molecular optimization from four rAAV expression systems are covered: adenovirus, herpesvirus, and baculovirus complementation systems, as well as a recently explored yeast expression system.

Retreatment with bevacizumab in patients with gynecologic malignancy is associated with clinical response and does not increase morbidity

Directory of Open Access Journals (Sweden)

Laskey RA

2014-03-01

Full Text Available Robin A Laskey,1 Scott D Richard,2 Ashlee L Smith,1 Jeff F Lin,1 Tiffany L Beck,3 Jamie L Lesnock,1 Joseph L Kelley 3rd,1 Alexander B Olawaiye,1 Paniti Sukumvanich,1 Thomas C Krivak4 1Division of Gynecologic Oncology, Magee-Womens Hospital of UPMC, Pittsburgh, 2Division of Gynecologic Oncology, Drexel University College of Medicine/Hahnemann University Hospital, Philadelphia, 3Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of UPMC, Pittsburgh, 4Division of Gynecologic Oncology, Western Pennsylvania Hospital, Pittsburgh, PA, USA Purpose: Bevacizumab (Bev is associated with improved progression-free survival in advanced epithelial ovarian cancer. The use of Bev in patients with gynecologic malignancy is increasing; however, little is known about cumulative toxicity and response in patients retreated with Bev. Our goal was to determine cumulative side effects and response in patients retreated with Bev. Patients and methods: Women with recurrent gynecologic malignancy treated with Bev between January 2007 and March 2012 at a single institution were identified, including a subset who received Bev in a subsequent regimen. The primary outcome was Bev-associated toxicity, and the secondary outcome was response. Results: Of 83 patients that received Bev for recurrent disease, 23 were retreated with Bev and four received Bev maintenance. Three patients (13% developed grade 3 or 4 hypertension; all had a history of chronic hypertension. One (4.3% patient developed grade 3 proteinuria, and one (4.3% developed an enterovaginal fistula. Four patients discontinued Bev secondary to toxicity. Toxicity was not related to the cumulative number of cycles. Twenty-six percent of patients responded to Bev retreatment. On univariate analysis, there was a significant (P=0.003 overall survival advantage when the Bev-free interval was >9 months (95% confidence interval [CI] 4.9–43.7 compared to ≤9 months (95% CI 2.1–11.5, 24

Automorphisms of Algebras and Bochner's Property for Vector Orthogonal Polynomials

Science.gov (United States)

Horozov, Emil

2016-05-01

We construct new families of vector orthogonal polynomials that have the property to be eigenfunctions of some differential operator. They are extensions of the Hermite and Laguerre polynomial systems. A third family, whose first member has been found by Y. Ben Cheikh and K. Douak is also constructed. The ideas behind our approach lie in the studies of bispectral operators. We exploit automorphisms of associative algebras which transform elementary vector orthogonal polynomial systems which are eigenfunctions of a differential operator into other systems of this type.

Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1

DEFF Research Database (Denmark)

End, Caroline; Lyer, Stefan; Renner, Marcus

2005-01-01

of a vector system that facilitates cloning of DMBT1 variants. We demonstrate applicability of the vector system by expression of the largest DMBT1 variant in a tetracycline-inducible mammalian expression system using the Chinese hamster ovary cell line. Yields up to 30 mg rDMBT1 per litre of cell culture......Deleted in malignant brain tumours 1 (DMBT1) codes for a approximately 340kDa glycoprotein with highly repetitive scavenger receptor cysteine-rich (SRCR) domains. DMBT1 was implicated in cancer, defence against viral and bacterial infections, and differentiation of epithelial cells. Recombinant...... yields, and protein preparations which may substantially vary due to differential processing and genetic polymorphism, all of which impedes functional research on DMBT1. Cloning of DMBT1 cDNAs is hampered because of the size and the 13 highly homologous SRCR exons. In this study, we report on the setup...

Battery electric vehicles - implications for the driver interface.

Science.gov (United States)

Neumann, Isabel; Krems, Josef F

2016-03-01

The current study examines the human-machine interface of a battery electric vehicle (BEV) from a user-perspective, focussing on the evaluation of BEV-specific displays, the relevance of provided information and challenges for drivers due to the concept of electricity in a road vehicle. A sample of 40 users drove a BEV for 6 months. Data were gathered at three points of data collection. Participants perceived the BEV-specific displays as only moderately reliable and helpful for estimating the displayed parameters. This was even less the case after driving the BEV for 3 months. A taxonomy of user requirements was compiled revealing the need for improved and additional information, especially regarding energy consumption and efficiency. Drivers had difficulty understanding electrical units and the energy consumption of the BEV. On the background of general principles for display design, results provide implications how to display relevant information and how to facilitate drivers' understanding of energy consumption in BEVs. Practitioner Summary: Battery electric vehicle (BEV) displays need to incorporate new information. A taxonomy of user requirements was compiled revealing the need for improved and additional information in the BEV interface. Furthermore, drivers had trouble understanding electrical units and energy consumption; therefore, appropriate assistance is required. Design principles which are specifically important in the BEV context are discussed.

The ecological foundations of transmission potential and vector-borne disease in urban landscapes.

Science.gov (United States)

LaDeau, Shannon L; Allan, Brian F; Leisnham, Paul T; Levy, Michael Z

2015-07-01

Urban transmission of arthropod-vectored disease has increased in recent decades. Understanding and managing transmission potential in urban landscapes requires integration of sociological and ecological processes that regulate vector population dynamics, feeding behavior, and vector-pathogen interactions in these unique ecosystems. Vectorial capacity is a key metric for generating predictive understanding about transmission potential in systems with obligate vector transmission. This review evaluates how urban conditions, specifically habitat suitability and local temperature regimes, and the heterogeneity of urban landscapes can influence the biologically-relevant parameters that define vectorial capacity: vector density, survivorship, biting rate, extrinsic incubation period, and vector competence.Urban landscapes represent unique mosaics of habitat. Incidence of vector-borne disease in urban host populations is rarely, if ever, evenly distributed across an urban area. The persistence and quality of vector habitat can vary significantly across socio-economic boundaries to influence vector species composition and abundance, often generating socio-economically distinct gradients of transmission potential across neighborhoods.Urban regions often experience unique temperature regimes, broadly termed urban heat islands (UHI). Arthropod vectors are ectothermic organisms and their growth, survival, and behavior are highly sensitive to environmental temperatures. Vector response to UHI conditions is dependent on regional temperature profiles relative to the vector's thermal performance range. In temperate climates UHI can facilitate increased vector development rates while having countervailing influence on survival and feeding behavior. Understanding how urban heat island (UHI) conditions alter thermal and moisture constraints across the vector life cycle to influence transmission processes is an important direction for both empirical and modeling research.There remain

Support vector machine based diagnostic system for breast cancer using swarm intelligence.

Science.gov (United States)

Chen, Hui-Ling; Yang, Bo; Wang, Gang; Wang, Su-Jing; Liu, Jie; Liu, Da-You

2012-08-01

Breast cancer is becoming a leading cause of death among women in the whole world, meanwhile, it is confirmed that the early detection and accurate diagnosis of this disease can ensure a long survival of the patients. In this paper, a swarm intelligence technique based support vector machine classifier (PSO_SVM) is proposed for breast cancer diagnosis. In the proposed PSO-SVM, the issue of model selection and feature selection in SVM is simultaneously solved under particle swarm (PSO optimization) framework. A weighted function is adopted to design the objective function of PSO, which takes into account the average accuracy rates of SVM (ACC), the number of support vectors (SVs) and the selected features simultaneously. Furthermore, time varying acceleration coefficients (TVAC) and inertia weight (TVIW) are employed to efficiently control the local and global search in PSO algorithm. The effectiveness of PSO-SVM has been rigorously evaluated against the Wisconsin Breast Cancer Dataset (WBCD), which is commonly used among researchers who use machine learning methods for breast cancer diagnosis. The proposed system is compared with the grid search method with feature selection by F-score. The experimental results demonstrate that the proposed approach not only obtains much more appropriate model parameters and discriminative feature subset, but also needs smaller set of SVs for training, giving high predictive accuracy. In addition, Compared to the existing methods in previous studies, the proposed system can also be regarded as a promising success with the excellent classification accuracy of 99.3% via 10-fold cross validation (CV) analysis. Moreover, a combination of five informative features is identified, which might provide important insights to the nature of the breast cancer disease and give an important clue for the physicians to take a closer attention. We believe the promising result can ensure that the physicians make very accurate diagnostic decision in

Multi-perspective views of students’ difficulties with one-dimensional vector and two-dimensional vector

Science.gov (United States)

Fauzi, Ahmad; Ratna Kawuri, Kunthi; Pratiwi, Retno

2017-01-01

Researchers of students’ conceptual change usually collects data from written tests and interviews. Moreover, reports of conceptual change often simply refer to changes in concepts, such as on a test, without any identification of the learning processes that have taken place. Research has shown that students have difficulties with vectors in university introductory physics courses and high school physics courses. In this study, we intended to explore students’ understanding of one-dimensional and two-dimensional vector in multi perspective views. In this research, we explore students’ understanding through test perspective and interviews perspective. Our research study adopted the mixed-methodology design. The participants of this research were sixty students of third semester of physics education department. The data of this research were collected by testand interviews. In this study, we divided the students’ understanding of one-dimensional vector and two-dimensional vector in two categories, namely vector skills of the addition of one-dimensionaland two-dimensional vector and the relation between vector skills and conceptual understanding. From the investigation, only 44% of students provided correct answer for vector skills of the addition of one-dimensional and two-dimensional vector and only 27% students provided correct answer for the relation between vector skills and conceptual understanding.

Custodial vector model

Science.gov (United States)

Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan; Frandsen, Mads T.; Hapola, Tuomas; Sannino, Francesco

2015-07-01

We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a S U (2 )L×S U (2 )R spectral global symmetry. This symmetry partially protects the electroweak S parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum and interactions with the standard model fields lead to distinct signatures at the LHC in the diboson, dilepton, and associated Higgs channels.

Vector Differential Calculus

OpenAIRE

HITZER, Eckhard MS

2002-01-01

This paper treats the fundamentals of the vector differential calculus part of universal geometric calculus. Geometric calculus simplifies and unifies the structure and notation of mathematics for all of science and engineering, and for technological applications. In order to make the treatment self-contained, I first compile all important geometric algebra relationships,which are necesssary for vector differential calculus. Then differentiation by vectors is introduced and a host of major ve...

Toxicity and efficacy of lomustine and bevacizumab in recurrent glioblastoma patients

DEFF Research Database (Denmark)

Jakobsen, J N; Urup, T; Grunnet, K

2018-01-01

The combination of lomustine and bevacizumab is a commonly used salvage treatment for recurrent glioblastoma (GBM). We investigated the toxicity and efficacy of lomustine plus bevacizumab (lom-bev) in a community-based patient cohort and made a comparison to another frequently used combination...... therapy consisting of irinotecan plus bevacizumab (iri-bev). Seventy patients with recurrent GBM were treated with lomustine 90 mg/m2 every 6 weeks and bevacizumab 10 mg/kg every 2 weeks. Toxicity was registered and compared to the toxicity observed in 219 recurrent GBM patients who had previously been......-bev is a well-tolerated treatment for recurrent GBM, although hematological toxicity may be a dose limiting factor. No significant differences between lom-bev and iri-bev were observed with regard to PFS or OS. The differences in toxicity profiles between lom-bev and iri-bev could guide treatment decision...

Application of Bred Vectors To Data Assimilation

Science.gov (United States)

Corazza, M.; Kalnay, E.; Patil, Dj

We introduced a statistic, the BV-dimension, to measure the effective local finite-time dimensionality of the atmosphere. We show that this dimension is often quite low, and suggest that this finding has important implications for data assimilation and the accuracy of weather forecasting (Patil et al, 2001). The original database for this study was the forecasts of the NCEP global ensemble forecasting system. The initial differences between the control forecast and the per- turbed forecasts are called bred vectors. The control and perturbed initial conditions valid at time t=n(t are evolved using the forecast model until time t=(n+1) (t. The differences between the perturbed and the control forecasts are scaled down to their initial amplitude, and constitute the bred vectors valid at (n+1) (t. Their growth rate is typically about 1.5/day. The bred vectors are similar by construction to leading Lya- punov vectors except that they have small but finite amplitude, and they are valid at finite times. The original NCEP ensemble data set has 5 independent bred vectors. We define a local bred vector at each grid point by choosing the 5 by 5 grid points centered at the grid point (a region of about 1100km by 1100km), and using the north-south and east- west velocity components at 500mb pressure level to form a 50 dimensional column vector. Since we have k=5 global bred vectors, we also have k local bred vectors at each grid point. We estimate the effective dimensionality of the subspace spanned by the local bred vectors by performing a singular value decomposition (EOF analysis). The k local bred vector columns form a 50xk matrix M. The singular values s(i) of M measure the extent to which the k column unit vectors making up the matrix M point in the direction of v(i). We define the bred vector dimension as BVDIM={Sum[s(i)]}^2/{Sum[s(i)]^2} For example, if 4 out of the 5 vectors lie along v, and one lies along v, the BV- dimension would be BVDIM[sqrt(4), 1, 0

Chikungunya Virus–Vector Interactions

Directory of Open Access Journals (Sweden)

Lark L. Coffey

2014-11-01

Full Text Available Chikungunya virus (CHIKV is a mosquito-borne alphavirus that causes chikungunya fever, a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has emerged in Africa, Indian Ocean islands, Asia, Europe, and the Americas, causing millions of human infections. Central to understanding CHIKV emergence is knowledge of the natural ecology of transmission and vector infection dynamics. This review presents current understanding of CHIKV infection dynamics in mosquito vectors and its relationship to human disease emergence. The following topics are reviewed: CHIKV infection and vector life history traits including transmission cycles, genetic origins, distribution, emergence and spread, dispersal, vector competence, vector immunity and microbial interactions, and co-infection by CHIKV and other arboviruses. The genetics of vector susceptibility and host range changes, population heterogeneity and selection for the fittest viral genomes, dual host cycling and its impact on CHIKV adaptation, viral bottlenecks and intrahost diversity, and adaptive constraints on CHIKV evolution are also discussed. The potential for CHIKV re-emergence and expansion into new areas and prospects for prevention via vector control are also briefly reviewed.

Extended vector-tensor theories

Energy Technology Data Exchange (ETDEWEB)

Kimura, Rampei; Naruko, Atsushi; Yoshida, Daisuke, E-mail: rampei@th.phys.titech.ac.jp, E-mail: naruko@th.phys.titech.ac.jp, E-mail: yoshida@th.phys.titech.ac.jp [Department of Physics, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551 (Japan)

2017-01-01

Recently, several extensions of massive vector theory in curved space-time have been proposed in many literatures. In this paper, we consider the most general vector-tensor theories that contain up to two derivatives with respect to metric and vector field. By imposing a degeneracy condition of the Lagrangian in the context of ADM decomposition of space-time to eliminate an unwanted mode, we construct a new class of massive vector theories where five degrees of freedom can propagate, corresponding to three for massive vector modes and two for massless tensor modes. We find that the generalized Proca and the beyond generalized Proca theories up to the quartic Lagrangian, which should be included in this formulation, are degenerate theories even in curved space-time. Finally, introducing new metric and vector field transformations, we investigate the properties of thus obtained theories under such transformations.

Supergravity inspired vector curvaton

International Nuclear Information System (INIS)

Dimopoulos, Konstantinos

2007-01-01

It is investigated whether a massive Abelian vector field, whose gauge kinetic function is growing during inflation, can be responsible for the generation of the curvature perturbation in the Universe. Particle production is studied and it is shown that the vector field can obtain a scale-invariant superhorizon spectrum of perturbations with a reasonable choice of kinetic function. After inflation the vector field begins coherent oscillations, during which it corresponds to pressureless isotropic matter. When the vector field dominates the Universe, its perturbations give rise to the observed curvature perturbation following the curvaton scenario. It is found that this is possible if, after the end of inflation, the mass of the vector field increases at a phase transition at temperature of order 1 TeV or lower. Inhomogeneous reheating, whereby the vector field modulates the decay rate of the inflaton, is also studied

Constraining vectors and axial-vectors in walking technicolour by a holographic principle

DEFF Research Database (Denmark)

D. Dietrich, Dennis; Kouvaris, Christoforos

2008-01-01

We use a holographic principle to study the low-energy spectrum of walking technicolour models. In particular, we predict the masses of the axial vectors as well as the decay constants of vectors and axial vectors as functions of the mass of the techni-rho. Given that there are very few...

Recommendation on vectors and vector-transmitted diseases

OpenAIRE

Netherlands Food and Consumer Product Safety Authority

2009-01-01

In view of their increasing risk of introduction and their possible implications in causing major disease outbreaks, vectors, as well as vector-transmitted diseases like dengue, West Nile disease, Lyme disease and bluetongue need to be recognised as a threat to public and animal health and to the economy, also in the Netherlands. There has been an increase in the incidence of these diseases in the past two to three decades. Climate changes and changes in the use of land, water managemen...

Direct-current vector control of three-phase grid-connected rectifier-inverter

Energy Technology Data Exchange (ETDEWEB)

Li, Shuhui; Haskew, Timothy A.; Hong, Yang-Ki; Xu, Ling [Department of Electrical and Computer Engineering, University of Alabama, Tuscaloosa, AL 35475 (United States)

2011-02-15

The three-phase grid-connected converter is widely used in renewable and electric power system applications. Traditionally, control of the three-phase grid-connected converter is based on the standard decoupled d-q vector control mechanism. Nevertheless, the study of this paper shows that there is a limitation in the conventional standard vector control method. Some of the limitations have also been found recently by other researchers. To overcome the shortage of the conventional vector control technique, this paper proposes a new direct-current d-q vector control mechanism in a nested-loop control structure, based on which an optimal control strategy is developed in a nonlinear programming formulation. The behaviors of both the conventional and proposed control methods are compared and evaluated in simulation and laboratory hardware experiment environments, both of which demonstrates that the proposed approach is effective for grid-connected power converter control in a wide system conditions while the conventional standard vector control approach may behave improperly especially when the converter operates beyond its PWM saturation limit. (author)

Gauge anomaly with vector and axial-vector fields in 6D curved space

Science.gov (United States)

Yajima, Satoshi; Eguchi, Kohei; Fukuda, Makoto; Oka, Tomonori

2018-03-01

Imposing the conservation equation of the vector current for a fermion of spin 1/2 at the quantum level, a gauge anomaly for the fermion coupling with non-Abelian vector and axial-vector fields in 6D curved space is expressed in tensorial form. The anomaly consists of terms that resemble the chiral U(1) anomaly and the commutator terms that disappear if the axial-vector field is Abelian.

MHD thrust vectoring of a rocket engine

Science.gov (United States)

Labaune, Julien; Packan, Denis; Tholin, Fabien; Chemartin, Laurent; Stillace, Thierry; Masson, Frederic

2016-09-01

In this work, the possibility to use MagnetoHydroDynamics (MHD) to vectorize the thrust of a solid propellant rocket engine exhaust is investigated. Using a magnetic field for vectoring offers a mass gain and a reusability advantage compared to standard gimbaled, elastomer-joint systems. Analytical and numerical models were used to evaluate the flow deviation with a 1 Tesla magnetic field inside the nozzle. The fluid flow in the resistive MHD approximation is calculated using the KRONOS code from ONERA, coupling the hypersonic CFD platform CEDRE and the electrical code SATURNE from EDF. A critical parameter of these simulations is the electrical conductivity, which was evaluated using a set of equilibrium calculations with 25 species. Two models were used: local thermodynamic equilibrium and frozen flow. In both cases, chlorine captures a large fraction of free electrons, limiting the electrical conductivity to a value inadequate for thrust vectoring applications. However, when using chlorine-free propergols with 1% in mass of alkali, an MHD thrust vectoring of several degrees was obtained.

Prolonged Integration Site Selection of a Lentiviral Vector in the Genome of Human Keratinocytes.

Science.gov (United States)

Qian, Wei; Wang, Yong; Li, Rui-Fu; Zhou, Xin; Liu, Jing; Peng, Dai-Zhi

2017-03-03

BACKGROUND Lentiviral vectors have been successfully used for human skin cell gene transfer studies. Defining the selection of integration sites for retroviral vectors in the host genome is crucial in risk assessment analysis of gene therapy. However, genome-wide analyses of lentiviral integration sites in human keratinocytes, especially after prolonged growth, are poorly understood. MATERIAL AND METHODS In this study, 874 unique lentiviral vector integration sites in human HaCaT keratinocytes after long-term culture were identified and analyzed with the online tool GTSG-QuickMap and SPSS software. RESULTS The data indicated that lentiviral vectors showed integration site preferences for genes and gene-rich regions. CONCLUSIONS This study will likely assist in determining the relative risks of the lentiviral vector system and in the design of a safe lentiviral vector system in the gene therapy of skin diseases.

Vector manifestation and violation of vector dominance in hot matter

International Nuclear Information System (INIS)

Harada, Masayasu; Sasaki, Chihiro

2004-01-01

We show the details of the calculation of the hadronic thermal corrections to the two-point functions in the effective field theory of QCD for pions and vector mesons based on the hidden local symmetry (HLS) in hot matter using the background field gauge. We study the temperature dependence of the pion velocity in the low-temperature region determined from the hadronic thermal corrections, and show that, due to the presence of the dynamical vector meson, the pion velocity is smaller than the speed of the light already at one-loop level, in contrast to the result obtained in the ordinary chiral perturbation theory including only the pion at one-loop. Including the intrinsic temperature dependences of the parameters of the HLS Lagrangian determined from the underlying QCD through the Wilsonian matching, we show how the vector manifestation (VM), in which the massless vector meson becomes the chiral partner of pion, is realized at the critical temperature. We present a new prediction of the VM on the direct photon-π-π coupling which measures the validity of the vector dominance (VD) of the electromagnetic form factor of the pion: we find that the VD is largely violated at the critical temperature, which indicates that the assumption of the VD made in several analyses on the dilepton spectra in hot matter may need to be weakened for consistently including the effect of the dropping mass of the vector meson

Analysis of low carbon super credit policy efficiency in European Union greenhouse gas emissions

International Nuclear Information System (INIS)

Álvarez, Roberto; Zubelzu, Sergio; Díaz, Guzmán; López, Alberto

2015-01-01

In this paper we address the current European Union's support policy for BEV (battery electric vehicles) manufacturing under the Super-credit modality, and its actual relationship with the reduction of carbon emissions derived from the use of battery electric vehicles (BEV). Particularly, we have estimated the BEV associated carbon emissions through the method provided by Intergovernmental Panel on Climate Change (IPCC). In this sense, we have employed a BEV model to investigate the BEV emissions by country in the EU according to the regional electricity mix. We additionally have accounted for the particularities of real-world driving, which further affects the results. We have employed a measure of driving aggressiveness by modifying the standard benchmarking driving cycle fostered by the European Union and of necessary application by vehicle manufacturers—the NEDC—to show that BEV emissions are not negligible when compared with internal combustion vehicles; mainly in urban environments. On the whole, in this paper we provide a revision framework of the Super Credits meant to support the increase of the BEV fleet in the European Union. In its current form, the Super-credits support policy is a constant ratio depending on the manufactured internal combustion vehicles. We claim, however, that they should depend on the BEV recipient country instead. By revising the European electricity mix, we demonstrate for instance that countries such as Poland, though indirectly, largely exceed the allowed limits of CO 2 emissions derived from the upstream generation of electricity required to load the BEV. - Highlights: • Super-credit support policy is aimed at promoting the manufacturing of BEV in the EU. • It does not account for upstream electricity generation in the BEV user country. • We analyze the generation emissions ensuing from the use of the BEV in EU countries. • We show that indirect carbon emissions in some countries exceed proposed targets. �

Heavy Scalar, Vector, and Axial-Vector Mesons in Hot and Dense Nuclear Medium

Directory of Open Access Journals (Sweden)

Arvind Kumar

2014-01-01

Full Text Available In this work we shall investigate the mass modifications of scalar mesons (D0; B0, vector mesons (D*; B*, and axial-vector mesons (D1; B1 at finite density and temperature of the nuclear medium. The above mesons are modified in the nuclear medium through the modification of quark and gluon condensates. We will find the medium modification of quark and gluon condensates within chiral SU(3 model through the medium modification of scalar-isoscalar fields σ and ζ at finite density and temperature. These medium modified quark and gluon condensates will further be used through QCD sum rules for the evaluation of in-medium properties of the above mentioned scalar, vector, and axial vector mesons. We will also discuss the effects of density and temperature of the nuclear medium on the scattering lengths of the above scalar, vector, and axial-vector mesons. The study of the medium modifications of the above mesons may be helpful for understanding their production rates in heavy-ion collision experiments. The results of present investigations of medium modifications of scalar, vector, and axial-vector mesons at finite density and temperature can be verified in the compressed baryonic matter (CBM experiment of FAIR facility at GSI, Germany.

Vector Fields on Product Manifolds

OpenAIRE

Kurz, Stefan

2011-01-01

This short report establishes some basic properties of smooth vector fields on product manifolds. The main results are: (i) On a product manifold there always exists a direct sum decomposition into horizontal and vertical vector fields. (ii) Horizontal and vertical vector fields are naturally isomorphic to smooth families of vector fields defined on the factors. Vector fields are regarded as derivations of the algebra of smooth functions.

Light scattering of rectangular slot antennas: parallel magnetic vector vs perpendicular electric vector

Science.gov (United States)

Lee, Dukhyung; Kim, Dai-Sik

2016-01-01

We study light scattering off rectangular slot nano antennas on a metal film varying incident polarization and incident angle, to examine which field vector of light is more important: electric vector perpendicular to, versus magnetic vector parallel to the long axis of the rectangle. While vector Babinet’s principle would prefer magnetic field along the long axis for optimizing slot antenna function, convention and intuition most often refer to the electric field perpendicular to it. Here, we demonstrate experimentally that in accordance with vector Babinet’s principle, the incident magnetic vector parallel to the long axis is the dominant component, with the perpendicular incident electric field making a small contribution of the factor of 1/|ε|, the reciprocal of the absolute value of the dielectric constant of the metal, owing to the non-perfectness of metals at optical frequencies.

Molecular dynamics simulation of a nanofluidic energy absorption system: effects of the chiral vector of carbon nanotubes.

Science.gov (United States)

Ganjiani, Sayed Hossein; Hossein Nezhad, Alireza

2018-02-14

A Nanofluidic Energy Absorption System (NEAS) is a novel nanofluidic system with a small volume and weight. In this system, the input mechanical energy is converted to surface tension energy during liquid infiltration in the nanotube. The NEAS is made of a mixture of nanoporous material particles in a functional liquid. In this work, the effects of the chiral vector of a carbon nanotube (CNT) on the performance characteristics of the NEAS are investigated by using molecular dynamics simulation. For this purpose, six CNTs with different diameters for each type of armchair, zigzag and chiral, and several chiral CNTs with different chiral vectors (different values of indices (m,n)) are selected and studied. The results show that in the chiral CNTs, the contact angle shows the hydrophobicity of the CNT, and infiltration pressure is reduced by increasing the values of m and n (increasing the CNT diameter). Contact angle and infiltration pressure are decreased by almost 1.4% and 9% at all diameters, as the type of CNT is changed from chiral to zigzag and then to armchair. Absorbed energy density and efficiency are also decreased by increasing m and n and by changing the type of CNT from chiral to zigzag and then to armchair.

Paralleled comparison of vectors for the generation of CAR-T cells.

Science.gov (United States)

Qin, Di-Yuan; Huang, Yong; Li, Dan; Wang, Yong-Sheng; Wang, Wei; Wei, Yu-Quan

2016-09-01

T-lymphocytes genetically engineered with the chimeric antigen receptor (CAR-T) have shown great therapeutic potential in cancer treatment. A variety of preclinical researches and clinical trials of CAR-T therapy have been carried out to lay the foundation for future clinical application. In these researches, several gene-transfer methods were used to deliver CARs or other genes into T-lymphocytes, equipping CAR-modified T cells with a property of recognizing and attacking antigen-expressing tumor cells in a major histocompatibility complex-independent manner. Here, we summarize the gene-transfer vectors commonly used in the generation of CAR-T cell, including retrovirus vectors, lentivirus vectors, the transposon/transposase system, the plasmid-based system, and the messenger RNA electroporation system. The following aspects were compared in parallel: efficiency of gene transfer, the integration methods in the modified T cells, foreground of scale-up production, and application and development in clinical trials. These aspects should be taken into account to generate the optimal CAR-gene vector that may be suitable for future clinical application.

Generalization of concurrence vectors

International Nuclear Information System (INIS)

Yu Changshui; Song Heshan

2004-01-01

In this Letter, based on the generalization of concurrence vectors for bipartite pure state with respect to employing tensor product of generators of the corresponding rotation groups, we generalize concurrence vectors to the case of mixed states; a new criterion of separability of multipartite pure states is given out, for which we define a concurrence vector; we generalize the vector to the case of multipartite mixed state and give out a good measure of free entanglement

Vector Network Coding Algorithms

OpenAIRE

Ebrahimi, Javad; Fragouli, Christina

2010-01-01

We develop new algebraic algorithms for scalar and vector network coding. In vector network coding, the source multicasts information by transmitting vectors of length L, while intermediate nodes process and combine their incoming packets by multiplying them with L x L coding matrices that play a similar role as coding c in scalar coding. Our algorithms for scalar network jointly optimize the employed field size while selecting the coding coefficients. Similarly, for vector coding, our algori...

Higher-dimensional generalizations of the Watanabe–Strogatz transform for vector models of synchronization

Science.gov (United States)

Lohe, M. A.

2018-06-01

We generalize the Watanabe–Strogatz (WS) transform, which acts on the Kuramoto model in d  =  2 dimensions, to a higher-dimensional vector transform which operates on vector oscillator models of synchronization in any dimension , for the case of identical frequency matrices. These models have conserved quantities constructed from the cross ratios of inner products of the vector variables, which are invariant under the vector transform, and have trajectories which lie on the unit sphere S d‑1. Application of the vector transform leads to a partial integration of the equations of motion, leaving independent equations to be solved, for any number of nodes N. We discuss properties of complete synchronization and use the reduced equations to derive a stability condition for completely synchronized trajectories on S d‑1. We further generalize the vector transform to a mapping which acts in and in particular preserves the unit ball , and leaves invariant the cross ratios constructed from inner products of vectors in . This mapping can be used to partially integrate a system of vector oscillators with trajectories in , and for d  =  2 leads to an extension of the Kuramoto system to a system of oscillators with time-dependent amplitudes and trajectories in the unit disk. We find an inequivalent generalization of the Möbius map which also preserves but leaves invariant a different set of cross ratios, this time constructed from the vector norms. This leads to a different extension of the Kuramoto model with trajectories in the complex plane that can be partially integrated by means of fractional linear transformations.

Is Vector Control Sufficient to Limit Pathogen Spread in Vineyards?

Science.gov (United States)

Daugherty, M P; O'Neill, S; Byrne, F; Zeilinger, A

2015-06-01

Vector control is widely viewed as an integral part of disease management. Yet epidemiological theory suggests that the effectiveness of control programs at limiting pathogen spread depends on a variety of intrinsic and extrinsic aspects of a pathosystem. Moreover, control programs rarely evaluate whether reductions in vector density or activity translate into reduced disease prevalence. In areas of California invaded by the glassy-winged sharpshooter (Homalodisca vitripennis Germar), Pierce's disease management relies heavily on chemical control of this vector, primarily via systemic conventional insecticides (i.e., imidacloprid). But, data are lacking that attribute reduced vector pressure and pathogen spread to sharpshooter control. We surveyed 34 vineyards over successive years to assess the epidemiological value of within-vineyard chemical control. The results showed that imidacloprid reduced vector pressure without clear nontarget effects or secondary pest outbreaks. Effects on disease prevalence were more nuanced. Treatment history over the preceding 5 yr affected disease prevalence, with significantly more diseased vines in untreated compared with regularly or intermittently treated vineyards. Yet, the change in disease prevalence between years was low, with no significant effects of insecticide treatment or vector abundance. Collectively, the results suggest that within-vineyard applications of imidacloprid can reduce pathogen spread, but with benefits that may take multiple seasons to become apparent. The relatively modest effect of vector control on disease prevalence in this system may be attributable in part to the currently low regional sharpshooter population densities stemming from area-wide control, without which the need for within-vineyard vector control would be more pronounced. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Experimental Evaluation of Integral Transformations for Engineering Drawings Vectorization

Directory of Open Access Journals (Sweden)

Vaský Jozef

2014-12-01

Full Text Available The concept of digital manufacturing supposes application of digital technologies in the whole product life cycle. Direct digital manufacturing includes such information technology processes, where products are directly manufactured from 3D CAD model. In digital manufacturing, engineering drawing is replaced by CAD product model. In the contemporary practice, lots of engineering paper-based drawings are still archived. They could be digitalized by scanner and stored to one of the raster graphics format and after that vectorized for interactive editing in the specific software system for technical drawing or for archiving in some of the standard vector graphics file format. The vector format is suitable for 3D model generating, too.The article deals with using of selected integral transformations (Fourier, Hough in the phase of digitalized raster engineering drawings vectorization.

Quantile Acoustic Vectors vs. MFCC Applied to Speaker Verification

Directory of Open Access Journals (Sweden)

Mayorga-Ortiz Pedro

2014-02-01

Full Text Available In this paper we describe speaker and command recognition related experiments, through quantile vectors and Gaussian Mixture Modelling (GMM. Over the past several years GMM and MFCC have become two of the dominant approaches for modelling speaker and speech recognition applications. However, memory and computational costs are important drawbacks, because autonomous systems suffer processing and power consumption constraints; thus, having a good trade-off between accuracy and computational requirements is mandatory. We decided to explore another approach (quantile vectors in several tasks and a comparison with MFCC was made. Quantile acoustic vectors are proposed for speaker verification and command recognition tasks and the results showed very good recognition efficiency. This method offered a good trade-off between computation times, characteristics vector complexity and overall achieved efficiency.

Support vector machine for automatic pain recognition

Science.gov (United States)

Monwar, Md Maruf; Rezaei, Siamak

2009-02-01

Facial expressions are a key index of emotion and the interpretation of such expressions of emotion is critical to everyday social functioning. In this paper, we present an efficient video analysis technique for recognition of a specific expression, pain, from human faces. We employ an automatic face detector which detects face from the stored video frame using skin color modeling technique. For pain recognition, location and shape features of the detected faces are computed. These features are then used as inputs to a support vector machine (SVM) for classification. We compare the results with neural network based and eigenimage based automatic pain recognition systems. The experiment results indicate that using support vector machine as classifier can certainly improve the performance of automatic pain recognition system.

Combining nonlinear multiresolution system and vector quantization for still image compression

Energy Technology Data Exchange (ETDEWEB)

Wong, Y.

1993-12-17

It is popular to use multiresolution systems for image coding and compression. However, general-purpose techniques such as filter banks and wavelets are linear. While these systems are rigorous, nonlinear features in the signals cannot be utilized in a single entity for compression. Linear filters are known to blur the edges. Thus, the low-resolution images are typically blurred, carrying little information. We propose and demonstrate that edge-preserving filters such as median filters can be used in generating a multiresolution system using the Laplacian pyramid. The signals in the detail images are small and localized to the edge areas. Principal component vector quantization (PCVQ) is used to encode the detail images. PCVQ is a tree-structured VQ which allows fast codebook design and encoding/decoding. In encoding, the quantization error at each level is fed back through the pyramid to the previous level so that ultimately all the error is confined to the first level. With simple coding methods, we demonstrate that images with PSNR 33 dB can be obtained at 0.66 bpp without the use of entropy coding. When the rate is decreased to 0.25 bpp, the PSNR of 30 dB can still be achieved. Combined with an earlier result, our work demonstrate that nonlinear filters can be used for multiresolution systems and image coding.

Effects of Vector Backbone and Pseudotype on Lentiviral Vector-mediated Gene Transfer: Studies in Infant ADA-Deficient Mice and Rhesus Monkeys

Science.gov (United States)

Carbonaro Sarracino, Denise; Tarantal, Alice F; Lee, C Chang I.; Martinez, Michele; Jin, Xiangyang; Wang, Xiaoyan; Hardee, Cinnamon L; Geiger, Sabine; Kahl, Christoph A; Kohn, Donald B

2014-01-01

Systemic delivery of a lentiviral vector carrying a therapeutic gene represents a new treatment for monogenic disease. Previously, we have shown that transfer of the adenosine deaminase (ADA) cDNA in vivo rescues the lethal phenotype and reconstitutes immune function in ADA-deficient mice. In order to translate this approach to ADA-deficient severe combined immune deficiency patients, neonatal ADA-deficient mice and newborn rhesus monkeys were treated with species-matched and mismatched vectors and pseudotypes. We compared gene delivery by the HIV-1-based vector to murine γ-retroviral vectors pseudotyped with vesicular stomatitis virus-glycoprotein or murine retroviral envelopes in ADA-deficient mice. The vesicular stomatitis virus-glycoprotein pseudotyped lentiviral vectors had the highest titer and resulted in the highest vector copy number in multiple tissues, particularly liver and lung. In monkeys, HIV-1 or simian immunodeficiency virus vectors resulted in similar biodistribution in most tissues including bone marrow, spleen, liver, and lung. Simian immunodeficiency virus pseudotyped with the gibbon ape leukemia virus envelope produced 10- to 30-fold lower titers than the vesicular stomatitis virus-glycoprotein pseudotype, but had a similar tissue biodistribution and similar copy number in blood cells. The relative copy numbers achieved in mice and monkeys were similar when adjusted to the administered dose per kg. These results suggest that this approach can be scaled-up to clinical levels for treatment of ADA-deficient severe combined immune deficiency subjects with suboptimal hematopoietic stem cell transplantation options. PMID:24925206

Effects of vector backbone and pseudotype on lentiviral vector-mediated gene transfer: studies in infant ADA-deficient mice and rhesus monkeys.

Science.gov (United States)

Carbonaro Sarracino, Denise; Tarantal, Alice F; Lee, C Chang I; Martinez, Michele; Jin, Xiangyang; Wang, Xiaoyan; Hardee, Cinnamon L; Geiger, Sabine; Kahl, Christoph A; Kohn, Donald B

2014-10-01

Systemic delivery of a lentiviral vector carrying a therapeutic gene represents a new treatment for monogenic disease. Previously, we have shown that transfer of the adenosine deaminase (ADA) cDNA in vivo rescues the lethal phenotype and reconstitutes immune function in ADA-deficient mice. In order to translate this approach to ADA-deficient severe combined immune deficiency patients, neonatal ADA-deficient mice and newborn rhesus monkeys were treated with species-matched and mismatched vectors and pseudotypes. We compared gene delivery by the HIV-1-based vector to murine γ-retroviral vectors pseudotyped with vesicular stomatitis virus-glycoprotein or murine retroviral envelopes in ADA-deficient mice. The vesicular stomatitis virus-glycoprotein pseudotyped lentiviral vectors had the highest titer and resulted in the highest vector copy number in multiple tissues, particularly liver and lung. In monkeys, HIV-1 or simian immunodeficiency virus vectors resulted in similar biodistribution in most tissues including bone marrow, spleen, liver, and lung. Simian immunodeficiency virus pseudotyped with the gibbon ape leukemia virus envelope produced 10- to 30-fold lower titers than the vesicular stomatitis virus-glycoprotein pseudotype, but had a similar tissue biodistribution and similar copy number in blood cells. The relative copy numbers achieved in mice and monkeys were similar when adjusted to the administered dose per kg. These results suggest that this approach can be scaled-up to clinical levels for treatment of ADA-deficient severe combined immune deficiency subjects with suboptimal hematopoietic stem cell transplantation options.

Validation of SplitVectors Encoding for Quantitative Visualization of Large-Magnitude-Range Vector Fields.

Science.gov (United States)

Henan Zhao; Bryant, Garnett W; Griffin, Wesley; Terrill, Judith E; Jian Chen

2017-06-01

We designed and evaluated SplitVectors, a new vector field display approach to help scientists perform new discrimination tasks on large-magnitude-range scientific data shown in three-dimensional (3D) visualization environments. SplitVectors uses scientific notation to display vector magnitude, thus improving legibility. We present an empirical study comparing the SplitVectors approach with three other approaches - direct linear representation, logarithmic, and text display commonly used in scientific visualizations. Twenty participants performed three domain analysis tasks: reading numerical values (a discrimination task), finding the ratio between values (a discrimination task), and finding the larger of two vectors (a pattern detection task). Participants used both mono and stereo conditions. Our results suggest the following: (1) SplitVectors improve accuracy by about 10 times compared to linear mapping and by four times to logarithmic in discrimination tasks; (2) SplitVectors have no significant differences from the textual display approach, but reduce cluttering in the scene; (3) SplitVectors and textual display are less sensitive to data scale than linear and logarithmic approaches; (4) using logarithmic can be problematic as participants' confidence was as high as directly reading from the textual display, but their accuracy was poor; and (5) Stereoscopy improved performance, especially in more challenging discrimination tasks.

Page segmentation using script identification vectors: A first look

Energy Technology Data Exchange (ETDEWEB)

Hochberg, J.; Cannon, M.; Kelly, P.; White, J.

1997-07-01

Document images in which different scripts, such as Chinese and Roman, appear on a single page pose a problem for optical character recognition (OCR) systems. This paper explores the use of script identification vectors in the analysis of multilingual document images. A script identification vector is calculated for each connected component in a document. The vector expresses the closest distance between the component and templates developed for each of thirteen scripts, including Arabic, Chinese, Cyrillic, and Roman. The authors calculate the first three principal components within the resulting thirteen-dimensional space for each image. By mapping these components to red, green, and blue, they can visualize the information contained in the script identification vectors. The visualization of several multilingual images suggests that the script identification vectors can be used to segment images into script-specific regions as large as several paragraphs or as small as a few characters. The visualized vectors also reveal distinctions within scripts, such as font in Roman documents, and kanji vs. kana in Japanese. Results are best for documents containing highly dissimilar scripts such as Roman and Japanese. Documents containing similar scripts, such as Roman and Cyrillic will require further investigation.

Traditional and robust vector selection methods for use with similarity based models

International Nuclear Information System (INIS)

Hines, J. W.; Garvey, D. R.

2006-01-01

Vector selection, or instance selection as it is often called in the data mining literature, performs a critical task in the development of nonparametric, similarity based models. Nonparametric, similarity based modeling (SBM) is a form of 'lazy learning' which constructs a local model 'on the fly' by comparing a query vector to historical, training vectors. For large training sets the creation of local models may become cumbersome, since each training vector must be compared to the query vector. To alleviate this computational burden, varying forms of training vector sampling may be employed with the goal of selecting a subset of the training data such that the samples are representative of the underlying process. This paper describes one such SBM, namely auto-associative kernel regression (AAKR), and presents five traditional vector selection methods and one robust vector selection method that may be used to select prototype vectors from a larger data set in model training. The five traditional vector selection methods considered are min-max, vector ordering, combination min-max and vector ordering, fuzzy c-means clustering, and Adeli-Hung clustering. Each method is described in detail and compared using artificially generated data and data collected from the steam system of an operating nuclear power plant. (authors)

Equivalent Vectors

Science.gov (United States)

Levine, Robert

2004-01-01

The cross-product is a mathematical operation that is performed between two 3-dimensional vectors. The result is a vector that is orthogonal or perpendicular to both of them. Learning about this for the first time while taking Calculus-III, the class was taught that if AxB = AxC, it does not necessarily follow that B = C. This seemed baffling. The…

Speculative dynamic vectorization to assist static vectorization in a HW/SW co-designed environment

OpenAIRE

Kumar, R.; Martinez, A.; Gonzalez, A.

2013-01-01

Compiler based static vectorization is used widely to extract data level parallelism from computation intensive applications. Static vectorization is very effective in vectorizing traditional array based applications. However, compilers inability to reorder ambiguous memory references severely limits vectorization opportunities, especially in pointer rich applications. HW/SW co-designed processors provide an excellent opportunity to optimize the applications at runtime. The availability of dy...

Stokes vector and its relationship to Discrete Wigner Functions of multiqubit states

Energy Technology Data Exchange (ETDEWEB)

Srinivasan, K., E-mail: sriniphysics@gmail.com; Raghavan, G.

2016-07-29

A Stokes vectors and Discrete Wigner Functions (DWF) provide two alternate ways of representing the state of multiqubit systems. A general relationship between the Stokes vector and the DWF is derived for arbitrary n-qubit states for all possible choices of quantum nets. The Stokes vector and the DWF are shown to be related through a Hadamard Matrix. Using these results, a relationship between the Stokes vector of a spin-flipped state and the DWF is derived. Finally, we also present a method to express the Minkowskian squared norm of the Stokes vector, corresponding to n-concurrence in terms of the DWF. - Highlights: • Relationship between Stokes vector (SV) and discrete Wigner function (DWF) for arbitrary multiqubit states is presented. • It is shown that SV and DWF are related to one another through Hadamard matrices. • We show that the Hadamard matrices depend on the choice of the quantum net. • Relationship between SV of the spin flipped state and the DWF is derived. • Expression to compute n-concurrence of the pure n-qubit systems purely in terms of DWF is given.

Stokes vector and its relationship to Discrete Wigner Functions of multiqubit states

International Nuclear Information System (INIS)

Srinivasan, K.; Raghavan, G.

2016-01-01

A Stokes vectors and Discrete Wigner Functions (DWF) provide two alternate ways of representing the state of multiqubit systems. A general relationship between the Stokes vector and the DWF is derived for arbitrary n-qubit states for all possible choices of quantum nets. The Stokes vector and the DWF are shown to be related through a Hadamard Matrix. Using these results, a relationship between the Stokes vector of a spin-flipped state and the DWF is derived. Finally, we also present a method to express the Minkowskian squared norm of the Stokes vector, corresponding to n-concurrence in terms of the DWF. - Highlights: • Relationship between Stokes vector (SV) and discrete Wigner function (DWF) for arbitrary multiqubit states is presented. • It is shown that SV and DWF are related to one another through Hadamard matrices. • We show that the Hadamard matrices depend on the choice of the quantum net. • Relationship between SV of the spin flipped state and the DWF is derived. • Expression to compute n-concurrence of the pure n-qubit systems purely in terms of DWF is given.

An Update on Canine Adenovirus Type 2 and Its Vectors

Science.gov (United States)

Bru, Thierry; Salinas, Sara; Kremer, Eric J.

2010-01-01

Adenovirus vectors have significant potential for long- or short-term gene transfer. Preclinical and clinical studies using human derived adenoviruses (HAd) have demonstrated the feasibility of flexible hybrid vector designs, robust expression and induction of protective immunity. However, clinical use of HAd vectors can, under some conditions, be limited by pre-existing vector immunity. Pre-existing humoral and cellular anti-capsid immunity limits the efficacy and duration of transgene expression and is poorly circumvented by injections of larger doses and immuno-suppressing drugs. This review updates canine adenovirus serotype 2 (CAV-2, also known as CAdV-2) biology and gives an overview of the generation of early region 1 (E1)-deleted to helper-dependent (HD) CAV-2 vectors. We also summarize the essential characteristics concerning their interaction with the anti-HAd memory immune responses in humans, the preferential transduction of neurons, and its high level of retrograde axonal transport in the central and peripheral nervous system. CAV-2 vectors are particularly interesting tools to study the pathophysiology and potential treatment of neurodegenerative diseases, as anti-tumoral and anti-viral vaccines, tracer of synaptic junctions, oncolytic virus and as a platform to generate chimeric vectors. PMID:21994722

Inadvertent gene silencing of argininosuccinate synthase (bcass1) in Botrytis cinerea by the pLOB1 vector system

NARCIS (Netherlands)

Patel, R.M.; Kan, van J.A.L.; Bailey, A.M.; Foster, G.D.

2010-01-01

For several years, researchers working on the plant pathogen Botrytis cinerea and a number of other related fungi have routinely used the pLOB1 vector system, based on hygromycin resistance, under the control of the Aspergillus nidulans oliC promoter and what was reported to be the ß-tubulin (tubA)

Observability of B0 - B vector0 mixing in the e+e- → BB vector X reaction at √s approx. = 15 - 30 GeV

International Nuclear Information System (INIS)

Fridman, A.; Schwarz, A.

1985-01-01

The possibility of observing mixing in the B 0 B vector B 0 system has been rather widely discussed. In particular theoretical estimates have been made for the case of B 0 B vector 0 production in the e + e - → upsilon (4S) → B 0 B vector 0 reaction. Mixing in this specific channel is expected to appear as a small effect and might thus be hardly measurable. Here the authors will therefore consider the e + e - → BB vector X reaction (X meaning anything well above the BB vector threshold where any combination of BB vector mesons (B/sub u/B vector/sub u/, B/sub u/B vector/sub d/, B/sub u/B vector/sub s/, etc.) can be produced. This reaction might be advantageous as mixing is expected to be almost complete for the B/sub s/ mesons. In this respect the study of mixing effects in the e + e - → BB vector X reaction is complementary to that in the e + e - → upsilon (4S) → B/sub d/ 0 B vector /sub e/ 0 process. In Section B.2 the authors recall briefly the parameters used to describe the BB vector mixing and in Section B.3 they give estimates for the mixing effects which could be observed in the e + e - → BB vector X reaction as well as in the upsilon (4S) decays. The authors have also evaluated the influence of a non-spectator component in the B-decay on the observability of the mixing phenomenon. Finally, in Section B.4 they give estimates for the number of signal and background events which could be observed in an e + e - experiment with an accumulated luminosity of 1000 pb -1 . 33 references, 4 figures

Control Instabilities in a Pulsed Multi-Cavity RF System with Vector Sum Feedback (A Mathematical Analysis) 052

CERN Document Server

Tückmantel, Joachim

2001-01-01

Upcoming projects relying on pulsed linear accelerators intend to use superconducting RF systems. Cost reasons suggest driving several cavities by a common transmitter, controlled over a vector sum feedback system, possibly supported by a feed forward system. Numerical simulations hint that such a system may become uncontrollable under certain conditions. In the present paper, for a model very close to reality, we will present a mathematical proof that in fact spontaneous symmetry braking is possible for these configurations, defining also the precise conditions under which it will take place. These can be used as an estimate for the real RF system stability limits. The listing of a small program demonstrating the mechanism numerically for two cavities is attached.

Large-scale adenovirus and poxvirus-vectored vaccine manufacturing to enable clinical trials.

Science.gov (United States)

Kallel, Héla; Kamen, Amine A

2015-05-01

Efforts to make vaccines against infectious diseases and immunotherapies for cancer have evolved to utilize a variety of heterologous expression systems such as viral vectors. These vectors are often attenuated or engineered to safely deliver genes encoding antigens of different pathogens. Adenovirus and poxvirus vectors are among the viral vectors that are most frequently used to develop prophylactic vaccines against infectious diseases as well as therapeutic cancer vaccines. This mini-review describes the trends and processes in large-scale production of adenovirus and poxvirus vectors to meet the needs of clinical applications. We briefly describe the general principles for the production and purification of adenovirus and poxvirus viral vectors. Currently, adenovirus and poxvirus vector manufacturing methods rely on well-established cell culture technologies. Several improvements have been evaluated to increase the yield and to reduce the overall manufacturing cost, such as cultivation at high cell densities and continuous downstream processing. Additionally, advancements in vector characterization will greatly facilitate the development of novel vectored vaccine candidates. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Vector parametrization, partial angular momenta and unusual commutation relations in physics

International Nuclear Information System (INIS)

Gatti, Fabien; Nauts, Andre

2003-01-01

When studying an N-particle system by means of N-1 vectors i.e., by means of a vector parametrization, one unavoidably comes across several angular momenta: not only the total angular momentum of the system but also the various partial angular momenta corresponding to the motion of the various vectors. All these momenta can, in addition, be referred to a variety of reference frames. The use of vector parametrizations and partial angular momenta in physics greatly simplifies the classical as well as quantum expressions of the kinetic energy. The present paper is devoted to a detailed and rigorous study of the partial angular momenta and the various commutation relations they satisfy, in particular the unusual commutation relations whose origin is traced back to the very structure of the coordinate changes used to define the Body-Fixed (BF) frames. The direct quantization of the classical expressions of the kinetic energy obtained in the context of various vector parametrizations is also given in detail. It turns out to be an efficient extension of well-known quantization procedures to the case where supernumerary quasi-momenta are used. As an illustration, the case of a four-particle system is treated in detail for a particular choice of the BF frames. Finally, the analogies between the classical and quantum approaches are emphasized

Vectorization at the KENO-IV code

International Nuclear Information System (INIS)

Asai, K.; Higuchi, K.; Katakura, J.

1986-01-01

The multigroup criticality safety code KENO-IV has been vectorized and tested on the FACOM VP-100 vector processor. At first, the vectorized KENO-IV on a scalar processor was slower than the original one by a factor of 1.4 because of the overhead introduced by vectorization. Making modifications of algorithms and techniques for vectorization, the vectorized version has become faster than the original one by a factor of 1.4 on the vector processor. For further speedup of the code, some improvements on compiler and hardware, especially on addition of Monte Carlo pipelines to the vector processor, are discussed

Reciprocity relationships in vector acoustics and their application to vector field calculations.

Science.gov (United States)

Deal, Thomas J; Smith, Kevin B

2017-08-01

The reciprocity equation commonly stated in underwater acoustics relates pressure fields and monopole sources. It is often used to predict the pressure measured by a hydrophone for multiple source locations by placing a source at the hydrophone location and calculating the field everywhere for that source. A similar equation that governs the orthogonal components of the particle velocity field is needed to enable this computational method to be used for acoustic vector sensors. This paper derives a general reciprocity equation that accounts for both monopole and dipole sources. This vector-scalar reciprocity equation can be used to calculate individual components of the received vector field by altering the source type used in the propagation calculation. This enables a propagation model to calculate the received vector field components for an arbitrary number of source locations with a single model run for each vector field component instead of requiring one model run for each source location. Application of the vector-scalar reciprocity principle is demonstrated with analytic solutions for a range-independent environment and with numerical solutions for a range-dependent environment using a parabolic equation model.

Vectors and their applications

CERN Document Server

Pettofrezzo, Anthony J

2005-01-01

Geared toward undergraduate students, this text illustrates the use of vectors as a mathematical tool in plane synthetic geometry, plane and spherical trigonometry, and analytic geometry of two- and three-dimensional space. Its rigorous development includes a complete treatment of the algebra of vectors in the first two chapters.Among the text's outstanding features are numbered definitions and theorems in the development of vector algebra, which appear in italics for easy reference. Most of the theorems include proofs, and coordinate position vectors receive an in-depth treatment. Key concept

Modulated molecular beam mass spectrometry: A generalized expression for the ''reaction product vector'' for linear systems

International Nuclear Information System (INIS)

Chang, H.; Weinberg, W.H.

1977-01-01

A generalized expression is developed that relates the ''reaction product vector'', epsilon exp(-iphi), to the kinetic parameters of a linear system. The formalism is appropriate for the analysis of modulated molecular beam mass spectrometry data and facilitates the correlation of experimental results to (proposed) linear models. A study of stability criteria appropriate for modulated molecular beam mass spectrometry experiments is also presented. This investigation has led to interesting inherent limitations which have not heretofore been emphasized, as well as a delineation of the conditions under which stable chemical oscillations may occur in the reacting system

Convexity and Marginal Vectors

NARCIS (Netherlands)

van Velzen, S.; Hamers, H.J.M.; Norde, H.W.

2002-01-01

In this paper we construct sets of marginal vectors of a TU game with the property that if the marginal vectors from these sets are core elements, then the game is convex.This approach leads to new upperbounds on the number of marginal vectors needed to characterize convexity.An other result is that

Hobo-like transposable elements as non-drosophilid gene vectors

International Nuclear Information System (INIS)

O'Brochta, D.A.; Warren, W.D.; Saville, K.J.; Whyard, S.; Mende, H.A.; Pinkerton, A.C.; Coates, C.J.; Atkinson, P.W.

1998-01-01

Using genetic and physical methods we discovered short-inverted repeat type transposable elements in non-drosophilid insects including, Bactorcera tryoni, Musca domestica, Musca vetustissima and Lucilia cuprina. These elements are related to hobo, Ac and Tam3. The Hermes element from M domestica is 2749 bp in length and has terminal inverted repeats and a transposase coding region very similar to those in hobo. Hermes is functional in M Domestic and can act as a gene vector in this species. When Hermes is introduced into D. melanogaster it is hyperactive, relative to existing vector systems used in this species. Hermes will be useful as a gene vector. (author)

Geminivirus vectors for high-level expression of foreign proteins in plant cells.

Science.gov (United States)

Mor, Tsafrir S; Moon, Yong-Sun; Palmer, Kenneth E; Mason, Hugh S

2003-02-20

Bean yellow dwarf virus (BeYDV) is a monopartite geminivirus that can infect dicotyledonous plants. We have developed a high-level expression system that utilizes elements of the replication machinery of this single-stranded DNA virus. The replication initiator protein (Rep) mediates release and replication of a replicon from a DNA construct ("LSL vector") that contains an expression cassette for a gene of interest flanked by cis-acting elements of the virus. We used tobacco NT1 cells and biolistic delivery of plasmid DNA for evaluation of replication and expression of reporter genes contained within an LSL vector. By codelivery of a GUS reporter-LSL vector and a Rep-supplying vector, we obtained up to 40-fold increase in expression levels compared to delivery of the reporter-LSL vectors alone. High-copy replication of the LSL vector was correlated with enhanced expression of GUS. Rep expression using a whole BeYDV clone, a cauliflower mosaic virus 35S promoter driving either genomic rep or an intron-deleted rep gene, or 35S-rep contained in the LSL vector all achieved efficient replication and enhancement of GUS expression. We anticipate that this system can be adapted for use in transgenic plants or plant cell cultures with appropriately regulated expression of Rep, with the potential to greatly increase yield of recombinant proteins. Copyright 2003 Wiley Periodicals, Inc. Biotechnol Bioeng 81: 430-437, 2003.

Retroviral Vectors: Post Entry Events and Genomic Alterations

Directory of Open Access Journals (Sweden)

Christof von Kalle

2011-04-01

Full Text Available The curative potential of retroviral vectors for somatic gene therapy has been demonstrated impressively in several clinical trials leading to sustained long-term correction of the underlying genetic defect. Preclinical studies and clinical monitoring of gene modified hematopoietic stem and progenitor cells in patients have shown that biologically relevant vector induced side effects, ranging from in vitro immortalization to clonal dominance and oncogenesis in vivo, accompany therapeutic efficiency of integrating retroviral gene transfer systems. Most importantly, it has been demonstrated that the genotoxic potential is not identical among all retroviral vector systems designed for clinical application. Large scale viral integration site determination has uncovered significant differences in the target site selection of retrovirus subfamilies influencing the propensity for inducing genetic alterations in the host genome. In this review we will summarize recent insights gained on the mechanisms of insertional mutagenesis based on intrinsic target site selection of different retrovirus families. We will also discuss examples of side effects occurring in ongoing human gene therapy trials and future prospectives in the field.

Indonesian Stock Prediction using Support Vector Machine (SVM

Directory of Open Access Journals (Sweden)

Santoso Murtiyanto

2018-01-01

Full Text Available This project is part of developing software to provide predictive information technology-based services artificial intelligence (Machine Intelligence or Machine Learning that will be utilized in the money market community. The prediction method used in this early stages uses the combination of Gaussian Mixture Model and Support Vector Machine with Python programming. The system predicts the price of Astra International (stock code: ASII.JK stock data. The data used was taken during 17 yr period of January 2000 until September 2017. Some data was used for training/modeling (80 % of data and the remainder (20 % was used for testing. An integrated model comprising Gaussian Mixture Model and Support Vector Machine system has been tested to predict stock market of ASII.JK for l d in advance. This model has been compared with the Market Cummulative Return. From the results, it is depicts that the Gaussian Mixture Model-Support Vector Machine based stock predicted model, offers significant improvement over the compared models resulting sharpe ratio of 3.22.

Vector financial rogue waves

International Nuclear Information System (INIS)

Yan, Zhenya

2011-01-01

The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black–Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields. -- Highlights: ► We investigate the coupled nonlinear volatility and option pricing model. ► We analytically present vector financial rogue waves. ► The vector financial rogue waves may be used to describe the extreme events in financial markets. ► This results may excite the relative researches and potential applications of vector rogue waves.

Video Vectorization via Tetrahedral Remeshing.

Science.gov (United States)

Wang, Chuan; Zhu, Jie; Guo, Yanwen; Wang, Wenping

2017-02-09

We present a video vectorization method that generates a video in vector representation from an input video in raster representation. A vector-based video representation offers the benefits of vector graphics, such as compactness and scalability. The vector video we generate is represented by a simplified tetrahedral control mesh over the spatial-temporal video volume, with color attributes defined at the mesh vertices. We present novel techniques for simplification and subdivision of a tetrahedral mesh to achieve high simplification ratio while preserving features and ensuring color fidelity. From an input raster video, our method is capable of generating a compact video in vector representation that allows a faithful reconstruction with low reconstruction errors.

Estimation of the environmental values of electric vehicles in Chinese cities

International Nuclear Information System (INIS)

Lin, Boqiang; Tan, Ruipeng

2017-01-01

Automobile exhaust emissions have been one of the serious air pollution sources in most Chinese cities and the adoption of new energy vehicles (NEVs) can solve this problem to some extent. In this context, NEVs can be seen as a kind of public good, part of whose value cannot be reflected in a market price. This paper estimates the environmental values of battery electric vehicles (BEVs) and studies the influencing factors based on a survey conducted in China's four biggest and developed cities: Beijing, Shanghai, Guangzhou, and Shenzhen. Contingent valuation method (CVM) and the ordered Probit model are employed to achieve the objective. The results show that the least average environmental values of a BEV are 30.60 thousand CNY in the four cities. People with higher income, already having private cars, knowing more about BEVs, thinking that BEVs can improve air quality or with higher levels of education are willing to pay more. Therefore, the policymakers should take the positive WTP of consumers for the environmental effects of BEVs into consideration when pricing the BEVs and reconsider the existing subsidies to BEVs. - Highlights: • The environmental values of a BEV are estimated by CVM and an ordered Probit model. • The study is based on a random survey in the four biggest and developed cities in China. • The survey is concerning public's attitude towards battery electric vehicles (BEVs). • People who are males, with a higher income, knowing more about BEVs or with a higher level of education have a higher WTP.

Improved stability and performance from sigma-delta modulators using 1-bit vector quantization

DEFF Research Database (Denmark)

Risbo, Lars

1993-01-01

A novel class of sigma-delta modulators is presented. The usual scalar 1-b quantizer in a sigma-delta modulator is replaced by a 1-b vector quantizer with a N-dimensional input state-vector from the linear feedback filter. Generally, the vector quantizer changes the nonlinear dynamics...... of the modulator, and a proper choice of vector quantizer can improve both system stability and coding performance. It is shown how to construct the vector quantizer in order to limit the excursions in state-space. The proposed method is demonstrated graphically for a simple second-order modulator...

A new approach to radiative transfer theory using Jones's vectors. I

International Nuclear Information System (INIS)

Fymat, A.L.; Vasudevan, R.

1975-01-01

Radiative transfer of partially polarized radiation in an anisotropically scattering, inhomogeneous atmosphere containing arbitrary polydispersion of particles is described using Jones's amplitude vectors and matrices. This novel approach exploits the close analogy between the quantum mechanical states of spin 1/2 systems and the polarization states of electromagnetic radiation described by Jones's vector, and draws on the methodology of such spin 1/2 systems. The complete equivalence between the transport equation for Jones's vectors and the classical radiative transfer equation for Stokes's intensity vectors is demonstrated in two independent ways after deriving the transport equations for the polarization coherency matrices and for the quaternions corresponding to the Jones's vectors. A compact operator formulation of the theory is provided, and used to derive the necessary equations for both a local and a global description of the transport of Jones's vectors. Lastly, the integro-differential equations for the amplitude reflection and transmission matrices are derived, and related to the usual corresponding equations. The present formulation is the most succinct and the most convenient one for both theoretical and experimental studies. It yields a simpler analysis than the classical formulation since it reduces by a factor of two the dimensionality of transfer problems. It preserves information on phases, and thus can be used directly across the entire electromagnetic spectrum without any further conversion into intensities. (Auth.)

Fault tolerant vector control of induction motor drive

International Nuclear Information System (INIS)

Odnokopylov, G; Bragin, A

2014-01-01

For electric composed of technical objects hazardous industries, such as nuclear, military, chemical, etc. an urgent task is to increase their resiliency and survivability. The construction principle of vector control system fault-tolerant asynchronous electric. Displaying recovery efficiency three-phase induction motor drive in emergency mode using two-phase vector control system. The process of formation of a simulation model of the asynchronous electric unbalance in emergency mode. When modeling used coordinate transformation, providing emergency operation electric unbalance work. The results of modeling transient phase loss motor stator. During a power failure phase induction motor cannot save circular rotating field in the air gap of the motor and ensure the restoration of its efficiency at rated torque and speed

The distribution and elimination of Bothrops erythromelas venom labeled with 131 I after intravenous injection in mice

International Nuclear Information System (INIS)

Rocha, M.L.

1999-01-01

Pharmacokinetic studies can be used to study the systemic effects of snake venoms and to develop standard serotherapy protocols for envenomation. Bothrops erythromelas is probably responsible for most of the snakebite in Pernambuco. The objective of this study was to investigate the pharmacokinetics of B. erythromelas venom (BeV) in mice, and to evaluate the efficacy of bothropic antivenom. BeV showed bicompartmental distribution in the blood of the experimental animals. (author)

The distribution and elimination of Bothrops erythromelas venom labeled with {sup 131} I after intravenous injection in mice

Energy Technology Data Exchange (ETDEWEB)

Rocha, M.L. [Pernambuco Univ., Recife, PE (Brazil). Dept. de Zoologia]. E-mail: rocha@cascavel.uefs.br

1999-07-01

Pharmacokinetic studies can be used to study the systemic effects of snake venoms and to develop standard serotherapy protocols for envenomation. Bothrops erythromelas is probably responsible for most of the snakebite in Pernambuco. The objective of this study was to investigate the pharmacokinetics of B. erythromelas venom (BeV) in mice, and to evaluate the efficacy of bothropic antivenom. BeV showed bicompartmental distribution in the blood of the experimental animals. (author)

Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement.

Science.gov (United States)

Wang, Yong; Yuan, Fan

2006-01-01

It is a challenge to deliver therapeutic genes to tumor cells using viral vectors because (i) the size of these vectors are close to or larger than the space between fibers in extracellular matrix and (ii) viral proteins are potentially toxic in normal tissues. In general, gene delivery is hindered by various physiological barriers to virus transport from the site of injection to the nucleus of tumor cells and is limited by normal tissue tolerance of toxicity determined by local concentrations of transgene products and viral proteins. To illustrate the obstacles encountered in the delivery and yet limit the scope of discussion, this review focuses only on extracellular transport in solid tumors and distribution of viral vectors in normal organs after they are injected intravenously or intratumorally. This review also discusses current strategies for improving intratumoral transport and specificity of viral vectors.

NI-60RECURRENT PATTERNS OF BEVACIZUMAB MONOTHERAPY FOR RECURRENT PRIMARY GLIOBLASTOMA AND PERSPECTIVES ON BEVACIZUMAB-BASED THERAPIES

Science.gov (United States)

Nagane, Motoo; Kobayashi, Keiichi; Saito, Kuniaki; Shiokawa, Yoshiaki

2014-01-01

BACKGROUND. Prognosis of patients with recurrent glioblastoma (GBM) remains dismal, their median overall survival (mOS) ranging from 7 to 10 months. Currently, bevacizumab (BEV), a monoclonal antibody against VEGF, has been widely used since it prolonged progression-free survival (PFS) accompanied with symptom relief in BEV trials. However, improvement of OS seems modest at most, and issues regarding short survival after BEV failure, invasive relapse, and difficulty in determining true progression remain unsolved. Here we examined the patterns of radiological BEV failure in relationship with survival of several post-treatment periods. METHODS. Twenty-five patients with primary GBM who were treated with BEV monotherapy at recurrence in Kyorin University hospital since August 2009 were included in this study. Mean age was 53 yo, 13 males/12 females, median KPS was 60 (30-100), and mOS from the initial surgery was 23.2 months. MRI patterns at BEV progression were determined using modified classification by Nowosielsky et al. (Neurology 2014) as follows: 1) T2-diffuse, 2) cT1-flare up, 3) Primary non-responders, 4) T2-circumscribed, and 5) Remote metastasis. RESULTS. mPFS and mOS of BEV monotherapy were 3.4 and 7.6 months, respectively, and post-BEV mOS was 4.7 months. Frequency and BEV-PFS/post-BEV OS were 1) 20%, 3.8/0.8 months; 2) 40%, 3.4/7.1 months, 3) 24%, 0.9/3.3 months, 4) 8%, 3.7/3.9 months, 5) 8%, 2.0/4.2 months. The cT1-flare up recurrent pattern was found most frequently with relatively better survivals, whereas the T2-diffuse recurrence included fatal brain stem invasion in two cases, resulting in poorer prognosis. CONCLUSIONS. BEV monotherapy showed limited survival benefit and the clinical course after BEV failure may differ by patterns of relapse. Although RANO criteria have been a standard method to determine progression, measurement of T2/FLAIR hyperintensity remains critically controversial. Efforts to improve BEV-based therapy for recurrent GBM

A Foxtail mosaic virus Vector for Virus-Induced Gene Silencing in Maize.

Science.gov (United States)

Mei, Yu; Zhang, Chunquan; Kernodle, Bliss M; Hill, John H; Whitham, Steven A

2016-06-01

Plant viruses have been widely used as vectors for foreign gene expression and virus-induced gene silencing (VIGS). A limited number of viruses have been developed into viral vectors for the purposes of gene expression or VIGS in monocotyledonous plants, and among these, the tripartite viruses Brome mosaic virus and Cucumber mosaic virus have been shown to induce VIGS in maize (Zea mays). We describe here a new DNA-based VIGS system derived from Foxtail mosaic virus (FoMV), a monopartite virus that is able to establish systemic infection and silencing of endogenous maize genes homologous to gene fragments inserted into the FoMV genome. To demonstrate VIGS applications of this FoMV vector system, four genes, phytoene desaturase (functions in carotenoid biosynthesis), lesion mimic22 (encodes a key enzyme of the porphyrin pathway), iojap (functions in plastid development), and brown midrib3 (caffeic acid O-methyltransferase), were silenced and characterized in the sweet corn line Golden × Bantam. Furthermore, we demonstrate that the FoMV infectious clone establishes systemic infection in maize inbred lines, sorghum (Sorghum bicolor), and green foxtail (Setaria viridis), indicating the potential wide applications of this viral vector system for functional genomics studies in maize and other monocots. © 2016 American Society of Plant Biologists. All Rights Reserved.

Vertical vector face lift.

Science.gov (United States)

Somoano, Brian; Chan, Joanna; Morganroth, Greg

2011-01-01

Facial rejuvenation using local anesthesia has evolved in the past decade as a safer option for patients seeking fewer complications and minimal downtime. Mini- and short-scar face lifts using more conservative incision lengths and extent of undermining can be effective in the younger patient with lower face laxity and minimal loose, elastotic neck skin. By incorporating both an anterior and posterior approach and using an incision length between the mini and more traditional face lift, the Vertical Vector Face Lift can achieve longer-lasting and natural results with lesser cost and risk. Submentoplasty and liposuction of the neck and jawline, fundamental components of the vertical vector face lift, act synergistically with superficial musculoaponeurotic system plication to reestablish a more youthful, sculpted cervicomental angle, even in patients with prominent jowls. Dramatic results can be achieved in the right patient by combining with other procedures such as injectable fillers, chin implants, laser resurfacing, or upper and lower blepharoplasties. © 2011 Wiley Periodicals, Inc.

Vector continued fractions using a generalized inverse

International Nuclear Information System (INIS)

Haydock, Roger; Nex, C M M; Wexler, Geoffrey

2004-01-01

A real vector space combined with an inverse (involution) for vectors is sufficient to define a vector continued fraction whose parameters consist of vector shifts and changes of scale. The choice of sign for different components of the vector inverse permits construction of vector analogues of the Jacobi continued fraction. These vector Jacobi fractions are related to vector and scalar-valued polynomial functions of the vectors, which satisfy recurrence relations similar to those of orthogonal polynomials. The vector Jacobi fraction has strong convergence properties which are demonstrated analytically, and illustrated numerically

Real Time Monitoring System of Pollution Waste on Musi River Using Support Vector Machine (SVM) Method

Science.gov (United States)

Fachrurrozi, Muhammad; Saparudin; Erwin

2017-04-01

Real-time Monitoring and early detection system which measures the quality standard of waste in Musi River, Palembang, Indonesia is a system for determining air and water pollution level. This system was designed in order to create an integrated monitoring system and provide real time information that can be read. It is designed to measure acidity and water turbidity polluted by industrial waste, as well as to show and provide conditional data integrated in one system. This system consists of inputting and processing the data, and giving output based on processed data. Turbidity, substances, and pH sensor is used as a detector that produce analog electrical direct current voltage (DC). Early detection system works by determining the value of the ammonia threshold, acidity, and turbidity level of water in Musi River. The results is then presented based on the level group pollution by the Support Vector Machine classification method.

An efficient transgenic system by TA cloning vectors and RNAi for C. elegans

International Nuclear Information System (INIS)

Gengyo-Ando, Keiko; Yoshina, Sawako; Inoue, Hideshi; Mitani, Shohei

2006-01-01

In the nematode, transgenic analyses have been performed by microinjection of DNA from various sources into the syncytium gonad. To expedite these transgenic analyses, we solved two potential problems in this work. First, we constructed an efficient TA-cloning vector system which is useful for any promoter. By amplifying the genomic DNA fragments which contain regulatory sequences with or without the coding region, we could easily construct plasmids expressing fluorescent protein fusion without considering restriction sites. We could dissect motor neurons with three colors in a single animal. Second, we used feeding RNAi to isolate transgenic strains which express lag-2::venus fusion gene. We found that the fusion protein is toxic when ectopically expressed in embryos but is functional to rescue a loss of function mutant in the lag-2 gene. Thus, the transgenic system described here should be useful to examine the protein function in the nematode

Genomic Analysis and Isolation of RNA Polymerase II Dependent Promoters from Spodoptera frugiperda.

Science.gov (United States)

Bleckmann, Maren; Fritz, Markus H-Y; Bhuju, Sabin; Jarek, Michael; Schürig, Margitta; Geffers, Robert; Benes, Vladimir; Besir, Hüseyin; van den Heuvel, Joop

2015-01-01

The Baculoviral Expression Vector System (BEVS) is the most commonly used method for high expression of recombinant protein in insect cells. Nevertheless, expression of some target proteins--especially those entering the secretory pathway--provides a severe challenge for the baculovirus infected insect cells, due to the reorganisation of intracellular compounds upon viral infection. Therefore, alternative strategies for recombinant protein production in insect cells like transient plasmid-based expression or stable expression cell lines are becoming more popular. However, the major bottleneck of these systems is the lack of strong endogenous polymerase II dependent promoters, as the strong baculoviral p10 and polH promoters used in BEVS are only functional in presence of the viral transcription machinery during the late phase of infection. In this work we present a draft genome and a transcriptome analysis of Sf21 cells for the identification of the first known endogenous Spodoptera frugiperda promoters. Therefore, putative promoter sequences were identified and selected because of high mRNA level or in analogy to other strong promoters in other eukaryotic organism. The chosen endogenous Sf21 promoters were compared to early viral promoters for their efficiency to trigger eGFP expression using transient plasmid based transfection in a BioLector Microfermentation system. Furthermore, promoter activity was not only shown in Sf21 cells but also in Hi5 cells. The novel endogenous Sf21 promoters were ranked according to their activity and expand the small pool of available promoters for stable insect cell line development and transient plasmid expression in insect cells. The best promoter was used to improve plasmid based transient transfection in insect cells substantially.

The Cross Product of Two Vectors Is Not Just Another Vector--A Major Misconception Being Perpetuated in Calculus and Vector Analysis Textbooks.

Science.gov (United States)

Elk, Seymour B.

1997-01-01

Suggests that the cross product of two vectors can be more easily and accurately explained by starting from the perspective of dyadics because then the concept of vector multiplication has a simple geometrical picture that encompasses both the dot and cross products in any number of dimensions in terms of orthogonal unit vector components. (AIM)

Major vectors and vector-borne diseases in small ruminants in Ethiopia: A systematic review.

Science.gov (United States)

Asmare, Kassahun; Abayneh, Takele; Sibhat, Berhanu; Shiferaw, Dessie; Szonyi, Barbara; Krontveit, Randi I; Skjerve, Eystein; Wieland, Barbara

2017-06-01

Vector-borne diseases are among major health constraints of small ruminant in Ethiopia. While various studies on single vector-borne diseases or presence of vectors have been conducted, no summarized evidence is available on the occurrence of these diseases and the related vectors. This systematic literature review provides a comprehensive summary on major vectors and vector-borne diseases in small ruminants in Ethiopia. Search for published and unpublished literature was conducted between 8th of January and 25th of June 2015. The search was both manual and electronic. The databases used in electronic search were PubMed, Web of Science, CAB Direct and AJOL. For most of the vector-borne diseases, the summary was limited to narrative synthesis due to lack of sufficient data. Meta-analysis was computed for trypanosomosis and dermatophilosis while meta-regression and sensitivity analysis was done only for trypanososmosis due to lack of sufficient reports on dermatophilosis. Owing emphasis to their vector role, ticks and flies were summarized narratively at genera/species level. In line with inclusion criteria, out of 106 initially identified research reports 43 peer-reviewed articles passed the quality assessment. Data on 7 vector-borne diseases were extracted at species and region level from each source. Accordingly, the pooled prevalence estimate of trypanosomosis was 3.7% with 95% confidence interval (CI) 2.8, 4.9), while that of dermatophilosis was 3.1% (95% CI: 1.6, 6.0). The in-between study variance noted for trypanosomosis was statistically significant (pparasitic presence in blood was documented for babesiosis (3.7% in goats); and anaplasmosis (3.9% in sheep). Serological evidence was retrieved for bluetongue ranging from 34.1% to 46.67% in sheep, and coxiellosis was 10.4% in goats. There was also molecular evidence on the presence of theileriosis in sheep (93%, n=160) and goats (1.9%, n=265). Regarding vectors of veterinary importance, 14 species of ticks in

Reduction of the state vector by a nonlinear Schrodinger equation

International Nuclear Information System (INIS)

Pearle, P.

1976-01-01

It is hypothesized that the state vector describes the physical state of a single system in nature. Then it is necessary that the state vector of a macroscopic apparatus not assume the form of a superposition of macroscopically distinguishable state vectors. To prevent this, it is suggested that a nonlinear term be added to the Schrodinger equation, which rapidly drives the amplitude of one or another of the state vectors in such a superposition to one, and the rest to zero. It is proposed that it is the phase angles of the amplitudes immediately after a measurement which determine which amplitude is driven to one. A diffusion equation is arrived at to describe the reduction of an ensemble of state vectors corresponding to an ensemble of macroscopically identically prepared experiments. Then a nonlinear term to add to the Schrodinger equation is presented, and it is shown that this leads to the diffusion equation in a weak-coupling approximation

Optical cage generated by azimuthal- and radial-variant vector beams.

Science.gov (United States)

Man, Zhongsheng; Bai, Zhidong; Li, Jinjian; Zhang, Shuoshuo; Li, Xiaoyu; Zhang, Yuquan; Ge, Xiaolu; Fu, Shenggui

2018-05-01

We propose a method to generate an optical cage using azimuthal- and radial-variant vector beams in a high numerical aperture optical system. A new kind of vector beam that has azimuthal- and radial-variant polarization states is proposed and demonstrated theoretically. Then, an integrated analytical model to calculate the electromagnetic field and Poynting vector distributions of the input azimuthal- and radial-variant vector beams is derived and built based on the vector diffraction theory of Richards and Wolf. From calculations, a full polarization-controlled optical cage is obtained by simply tailoring the radial index of the polarization, the uniformity U of which is up to 0.7748, and the cleanness C is zero. Additionally, a perfect optical cage can be achieved with U=1, and C=0 by introducing an amplitude modulation; its magnetic field and energy flow are also demonstrated in detail. Such optical cages may be helpful in applications such as optical trapping and high-resolution imaging.

Development of new USER-based cloning vectors for multiple genes expression in Saccharomyces cerevisiae

DEFF Research Database (Denmark)

Kildegaard, Kanchana Rueksomtawin; Jensen, Niels Bjerg; Maury, Jerome

2013-01-01

auxotrophic and dominant markers for convenience of use. Our vector set also contains both integrating and multicopy vectors for stability of protein expression and high expression level. We will make the new vector system available to the yeast community and provide a comprehensive protocol for cloning...... the production strain with the proper phenotype and product yield. However, the sequential number of metabolic engineering is time-consuming. Furthermore, the number of available selectable markers is also limiting the number of genetic modifications. To overcome these limitations, we have developed a new set...... of shuttle vectors for convenience of use for high-throughput cloning and selectable marker recycling. The new USER-based cloning vectors consist of a unique USER site and a CRE-loxP-mediated marker recycling system. The USER site allows insertion of genes of interest along with a bidirectional promoter...

GPU Accelerated Vector Median Filter

Science.gov (United States)

Aras, Rifat; Shen, Yuzhong

2011-01-01

Noise reduction is an important step for most image processing tasks. For three channel color images, a widely used technique is vector median filter in which color values of pixels are treated as 3-component vectors. Vector median filters are computationally expensive; for a window size of n x n, each of the n(sup 2) vectors has to be compared with other n(sup 2) - 1 vectors in distances. General purpose computation on graphics processing units (GPUs) is the paradigm of utilizing high-performance many-core GPU architectures for computation tasks that are normally handled by CPUs. In this work. NVIDIA's Compute Unified Device Architecture (CUDA) paradigm is used to accelerate vector median filtering. which has to the best of our knowledge never been done before. The performance of GPU accelerated vector median filter is compared to that of the CPU and MPI-based versions for different image and window sizes, Initial findings of the study showed 100x improvement of performance of vector median filter implementation on GPUs over CPU implementations and further speed-up is expected after more extensive optimizations of the GPU algorithm .

Design and experimental verification for optical module of optical vector-matrix multiplier.

Science.gov (United States)

Zhu, Weiwei; Zhang, Lei; Lu, Yangyang; Zhou, Ping; Yang, Lin

2013-06-20

Optical computing is a new method to implement signal processing functions. The multiplication between a vector and a matrix is an important arithmetic algorithm in the signal processing domain. The optical vector-matrix multiplier (OVMM) is an optoelectronic system to carry out this operation, which consists of an electronic module and an optical module. In this paper, we propose an optical module for OVMM. To eliminate the cross talk and make full use of the optical elements, an elaborately designed structure that involves spherical lenses and cylindrical lenses is utilized in this optical system. The optical design software package ZEMAX is used to optimize the parameters and simulate the whole system. Finally, experimental data is obtained through experiments to evaluate the overall performance of the system. The results of both simulation and experiment indicate that the system constructed can implement the multiplication between a matrix with dimensions of 16 by 16 and a vector with a dimension of 16 successfully.

Vectorization, parallelization and porting of nuclear codes (porting). Progress report fiscal 1999

Energy Technology Data Exchange (ETDEWEB)

Kawasaki, Nobuo; Nemoto, Toshiyuki; Kawai, Wataru; Ishizuki, Shigeru [Fujitsu Ltd., Tokyo (Japan); Ogasawara, Shinobu; Kume, Etsuo; Adachi, Masaaki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Yatake, Yo-ichi [Hitachi Ltd., Tokyo (Japan)

2001-01-01

Several computer codes in the nuclear field have been vectorized, parallelized and transported on the FUJITSU VPP500 system, the AP3000 system, the SX-4 system and the Paragon system at Center for Promotion of Computational Science and Engineering in Japan Atomic Energy Research Institute. We dealt with 18 codes in fiscal 1999. These results are reported in 3 parts, i.e., the vectorization and the parallelization part on vector processors, the parallelization port on scalar processors and the porting part. In this report, we describe the porting. In this porting part, the porting of Assisted Model Building with Energy Refinement code version 5 (AMBER5), general purpose Monte Carlo codes far neutron and photon transport calculations based on continuous energy and multigroup methods (MVP/GMVP), automatic editing system for MCNP library code (autonj), neutron damage calculations for materials irradiations and neutron damage calculations for compounds code (SPECTER/SPECOMP), severe accident analysis code (MELCOR) and COolant Boiling in Rod Arrays, Two-Fluid code (COBRA-TF) on the VPP500 system and/or the AP3000 system are described. (author)

Sleeping Beauty-baculovirus hybrid vectors for long-term gene expression in the eye.

Science.gov (United States)

Turunen, Tytteli Anni Kaarina; Laakkonen, Johanna Päivikki; Alasaarela, Laura; Airenne, Kari Juhani; Ylä-Herttuala, Seppo

2014-01-01

A baculovirus vector is capable of efficiently transducing many nondiving and diving cell types. However, the potential of baculovirus is restricted for many gene delivery applications as a result of the transient gene expression that it mediates. The plasmid-based Sleeping Beauty (SB) transposon system integrates transgenes into target cell genome efficiently with a genomic integration pattern that is generally considered safer than the integration of many other integrating vectors; yet efficient delivery of therapeutic genes into cells of target tissues in vivo is a major challenge for nonviral gene therapy. In the present study, SB was introduced into baculovirus to obtain novel hybrid vectors that would combine the best features of the two vector systems (i.e. effective gene delivery and efficient integration into the genome), thus circumventing the major limitations of these vectors. We constructed and optimized SB-baculovirus hybrid vectors that bear either SB100x transposase or SB transposon in the forward or reverse orientations with respect to the viral backbone The functionality of the novel hybrid vectors was investigated in cell cultures and in a proof-of-concept study in the mouse eye. The hybrid vectors showed high and sustained transgene expression that remained stable and demonstrated no signs of decline during the 2 months follow-up in vitro. These results were verified in the mouse eye where persistent transgene expression was detected two months after intravitreal injection. Our results confirm that (i) SB-baculovirus hybrid vectors mediate long-term gene expression in vitro and in vivo, and (ii) the hybrid vectors are potential new tools for the treatment of ocular diseases. Copyright © 2014 John Wiley & Sons, Ltd.

Effects of Climate and Climate Change on Vectors and Vector-Borne Diseases: Ticks Are Different.

Science.gov (United States)

Ogden, Nick H; Lindsay, L Robbin

2016-08-01

There has been considerable debate as to whether global risk from vector-borne diseases will be impacted by climate change. This has focussed on important mosquito-borne diseases that are transmitted by the vectors from infected to uninfected humans. However, this debate has mostly ignored the biological diversity of vectors and vector-borne diseases. Here, we review how climate and climate change may impact those most divergent of arthropod disease vector groups: multivoltine insects and hard-bodied (ixodid) ticks. We contrast features of the life cycles and behaviour of these arthropods, and how weather, climate, and climate change may have very different impacts on the spatiotemporal occurrence and abundance of vectors, and the pathogens they transmit. Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Hierarchal scalar and vector tetrahedra

International Nuclear Information System (INIS)

Webb, J.P.; Forghani, B.

1993-01-01

A new set of scalar and vector tetrahedral finite elements are presented. The elements are hierarchal, allowing mixing of polynomial orders; scalar orders up to 3 and vector orders up to 2 are defined. The vector elements impose tangential continuity on the field but not normal continuity, making them suitable for representing the vector electric or magnetic field. Further, the scalar and vector elements are such that they can easily be used in the same mesh, a requirement of many quasi-static formulations. Results are presented for two 50 Hz problems: the Bath Cube, and TEAM Problem 7

Optimizing structure of complex technical system by heterogeneous vector criterion in interval form

Science.gov (United States)

Lysenko, A. V.; Kochegarov, I. I.; Yurkov, N. K.; Grishko, A. K.

2018-05-01

The article examines the methods of development and multi-criteria choice of the preferred structural variant of the complex technical system at the early stages of its life cycle in the absence of sufficient knowledge of parameters and variables for optimizing this structure. The suggested methods takes into consideration the various fuzzy input data connected with the heterogeneous quality criteria of the designed system and the parameters set by their variation range. The suggested approach is based on the complex use of methods of interval analysis, fuzzy sets theory, and the decision-making theory. As a result, the method for normalizing heterogeneous quality criteria has been developed on the basis of establishing preference relations in the interval form. The method of building preferential relations in the interval form on the basis of the vector of heterogeneous quality criteria suggest the use of membership functions instead of the coefficients considering the criteria value. The former show the degree of proximity of the realization of the designed system to the efficient or Pareto optimal variants. The study analyzes the example of choosing the optimal variant for the complex system using heterogeneous quality criteria.

Patient setup aid with wireless CCTV system in radiation therapy

Energy Technology Data Exchange (ETDEWEB)

Park, Yang Kyun; Cho, Woong; Park, Jong Min [Seoul National University Graduate School, Seoul (Korea, Republic of); Ha, Sung Whan; Ye, Sung Joon [Seoul National University College of Medicine, Seoul (Korea, Republic of); Park, Suk Won [Chung-Ang University Cellege of Medicine, Seoul (Korea, Republic of); Huh, Soon Nyung [Seoul National University Hospital, Seoul (Korea, Republic of)

2006-12-15

To develop a wireless CCTV system in semi-beam's eye view (BEV) to monitor daily patient setup in radiation therapy. In order to get patient images in semi-BEV, CCTV cameras are installed in a custom-made acrylic applicator below the treatment head of a linear accelerator. The images from the cameras are transmitted via radio frequency signal ( {approx} 2.4 GHz and 10 mW RF output). An expected problem with this system is radio frequency interference, which is solved utilizing RF shielding with Cu foils and median filtering software. The images are analyzed by our custom-made software. In the software, three anatomical landmarks in the patient surface are indicated by a user, then automatically the 3 dimensional structures are obtained and registered by utilizing a localization procedure consisting mainly of stereo matching algorithm and Gauss-Newton optimization. This algorithm is applied to phantom images in investigate the setup accuracy. Respiratory gating system is also researched with real-time image processing. A line-laser marker projected on a patient's surface is extracted by binary image processing and the breath pattern is calculated and displayed in real-time. More than 80% of the camera noises from the linear accelerator are eliminated by wrapping the camera with copper foils. The accuracy of the localization procedure is found to be on the order of 1.5 {+-} 0.7 mm with a point phantom and sub-millimeters and degrees with a custom-made head/neck phantom. With line-laser marker, real-time respiratory monitoring is possible in the delay time of {approx} 0.7 sec. The wireless CCTV camera system is the novel tool which can monitor daily patient setups. The feasibility of respiratory gating system with the wireless CCTV is hopeful.

Patient setup aid with wireless CCTV system in radiation therapy

International Nuclear Information System (INIS)

Park, Yang Kyun; Cho, Woong; Park, Jong Min; Ha, Sung Whan; Ye, Sung Joon; Park, Suk Won; Huh, Soon Nyung

2006-01-01

To develop a wireless CCTV system in semi-beam's eye view (BEV) to monitor daily patient setup in radiation therapy. In order to get patient images in semi-BEV, CCTV cameras are installed in a custom-made acrylic applicator below the treatment head of a linear accelerator. The images from the cameras are transmitted via radio frequency signal ( ∼ 2.4 GHz and 10 mW RF output). An expected problem with this system is radio frequency interference, which is solved utilizing RF shielding with Cu foils and median filtering software. The images are analyzed by our custom-made software. In the software, three anatomical landmarks in the patient surface are indicated by a user, then automatically the 3 dimensional structures are obtained and registered by utilizing a localization procedure consisting mainly of stereo matching algorithm and Gauss-Newton optimization. This algorithm is applied to phantom images in investigate the setup accuracy. Respiratory gating system is also researched with real-time image processing. A line-laser marker projected on a patient's surface is extracted by binary image processing and the breath pattern is calculated and displayed in real-time. More than 80% of the camera noises from the linear accelerator are eliminated by wrapping the camera with copper foils. The accuracy of the localization procedure is found to be on the order of 1.5 ± 0.7 mm with a point phantom and sub-millimeters and degrees with a custom-made head/neck phantom. With line-laser marker, real-time respiratory monitoring is possible in the delay time of ∼ 0.7 sec. The wireless CCTV camera system is the novel tool which can monitor daily patient setups. The feasibility of respiratory gating system with the wireless CCTV is hopeful

Preliminary examples of 3D vector flow imaging

DEFF Research Database (Denmark)

Pihl, Michael Johannes; Stuart, Matthias Bo; Tomov, Borislav Gueorguiev

2013-01-01

This paper presents 3D vector flow images obtained using the 3D Transverse Oscillation (TO) method. The method employs a 2D transducer and estimates the three velocity components simultaneously, which is important for visualizing complex flow patterns. Data are acquired using the experimental ult...... as opposed to magnetic resonance imaging (MRI). The results demonstrate that the 3D TO method is capable of performing 3D vector flow imaging.......This paper presents 3D vector flow images obtained using the 3D Transverse Oscillation (TO) method. The method employs a 2D transducer and estimates the three velocity components simultaneously, which is important for visualizing complex flow patterns. Data are acquired using the experimental...... ultrasound scanner SARUS on a flow rig system with steady flow. The vessel of the flow-rig is centered at a depth of 30 mm, and the flow has an expected 2D circular-symmetric parabolic prole with a peak velocity of 1 m/s. Ten frames of 3D vector flow images are acquired in a cross-sectional plane orthogonal...

On the population dynamics of the malaria vector

International Nuclear Information System (INIS)

Ngwa, G.A.

2005-10-01

A deterministic differential equation model for the population dynamics of the human malaria vector is derived and studied. Conditions for the existence and stability of a non-zero steady state vector population density are derived. These reveal that a threshold parameter, the vectorial basic reproduction number, exist and the vector can establish itself in the community if and only if this parameter exceeds unity. When a non-zero steady state population density exists, it can be stable but it can also be driven to instability via a Hopf Bifurcation to periodic solutions, as a parameter is varied in parameter space. By considering a special case, an asymptotic perturbation analysis is used to derive the amplitude of the oscillating solutions for the full non-linear system. The present modelling exercise and results show that it is possible to study the population dynamics of disease vectors, and hence oscillatory behaviour as it is often observed in most indirectly transmitted infectious diseases of humans, without recourse to external seasonal forcing. (author)

Stealth configurations in vector-tensor theories of gravity

Science.gov (United States)

Chagoya, Javier; Tasinato, Gianmassimo

2018-01-01

Studying the physics of compact objects in modified theories of gravity is important for understanding how future observations can test alternatives to General Relativity. We consider a subset of vector-tensor Galileon theories of gravity characterized by new symmetries, which can prevent the propagation of the vector longitudinal polarization, even in absence of Abelian gauge invariance. We investigate new spherically symmetric and slowly rotating solutions for these systems, including an arbitrary matter Lagrangian. We show that, under certain conditions, there always exist stealth configurations whose geometry coincides with solutions of Einstein gravity coupled with the additional matter. Such solutions have a non-trivial profile for the vector field, characterized by independent integration constants, which extends to asymptotic infinity. We interpret our findings in terms of the symmetries and features of the original vector-tensor action, and on the number of degrees of freedom that it propagates. These results are important to eventually describe gravitationally bound configurations in modified theories of gravity, such as black holes and neutron stars, including realistic matter fields forming or surrounding the object.

Generation of arbitrary vector fields based on a pair of orthogonal elliptically polarized base vectors.

Science.gov (United States)

Xu, Danfeng; Gu, Bing; Rui, Guanghao; Zhan, Qiwen; Cui, Yiping

2016-02-22

We present an arbitrary vector field with hybrid polarization based on the combination of a pair of orthogonal elliptically polarized base vectors on the Poincaré sphere. It is shown that the created vector field is only dependent on the latitude angle 2χ but is independent on the longitude angle 2ψ on the Poincaré sphere. By adjusting the latitude angle 2χ, which is related to two identical waveplates in a common path interferometric arrangement, one could obtain arbitrary type of vector fields. Experimentally, we demonstrate the generation of such kind of vector fields and confirm the distribution of state of polarization by the measurement of Stokes parameters. Besides, we investigate the tight focusing properties of these vector fields. It is found that the additional degree of freedom 2χ provided by arbitrary vector field with hybrid polarization allows one to control the spatial structure of polarization and to engineer the focusing field.

Parallel computation for distributed parameter system-from vector processors to Adena computer

Energy Technology Data Exchange (ETDEWEB)

Nogi, T

1983-04-01

Research on advanced parallel hardware and software architectures for very high-speed computation deserves and needs more support and attention to fulfil its promise. Novel architectures for parallel processing are being made ready. Architectures for parallel processing can be roughly divided into two groups. One is a vector processor in which a single central processing unit involves multiple vector-arithmetic registers. The other is a processor array in which slave processors are connected to a host processor to perform parallel computation. In this review, the concept and data structure of the Adena (alternating-direction edition nexus array) architecture, which is conformable to distributed-parameter simulation algorithms, are described. 5 references.

Calculus with vectors

CERN Document Server

Treiman, Jay S

2014-01-01

Calculus with Vectors grew out of a strong need for a beginning calculus textbook for undergraduates who intend to pursue careers in STEM. fields. The approach introduces vector-valued functions from the start, emphasizing the connections between one-variable and multi-variable calculus. The text includes early vectors and early transcendentals and includes a rigorous but informal approach to vectors. Examples and focused applications are well presented along with an abundance of motivating exercises. All three-dimensional graphs have rotatable versions included as extra source materials and may be freely downloaded and manipulated with Maple Player; a free Maple Player App is available for the iPad on iTunes. The approaches taken to topics such as the derivation of the derivatives of sine and cosine, the approach to limits, and the use of "tables" of integration have been modified from the standards seen in other textbooks in order to maximize the ease with which students may comprehend the material. Additio...

Test of understanding of vectors: A reliable multiple-choice vector concept test

Science.gov (United States)

Barniol, Pablo; Zavala, Genaro

2014-06-01

In this article we discuss the findings of our research on students' understanding of vector concepts in problems without physical context. First, we develop a complete taxonomy of the most frequent errors made by university students when learning vector concepts. This study is based on the results of several test administrations of open-ended problems in which a total of 2067 students participated. Using this taxonomy, we then designed a 20-item multiple-choice test [Test of understanding of vectors (TUV)] and administered it in English to 423 students who were completing the required sequence of introductory physics courses at a large private Mexican university. We evaluated the test's content validity, reliability, and discriminatory power. The results indicate that the TUV is a reliable assessment tool. We also conducted a detailed analysis of the students' understanding of the vector concepts evaluated in the test. The TUV is included in the Supplemental Material as a resource for other researchers studying vector learning, as well as instructors teaching the material.

DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations

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Maria Schnödt

2016-01-01

Full Text Available Adeno-associated viral (AAV vectors are considered as one of the most promising delivery systems in human gene therapy. In addition, AAV vectors are frequently applied tools in preclinical and basic research. Despite this success, manufacturing pure AAV vector preparations remains a difficult task. While empty capsids can be removed from vector preparations owing to their lower density, state-of-the-art purification strategies as of yet failed to remove antibiotic resistance genes or other plasmid backbone sequences. Here, we report the development of minicircle (MC constructs to replace AAV vector and helper plasmids for production of both, single-stranded (ss and self-complementary (sc AAV vectors. As bacterial backbone sequences are removed during MC production, encapsidation of prokaryotic plasmid backbone sequences is avoided. This is of particular importance for scAAV vector preparations, which contained an unproportionally high amount of plasmid backbone sequences (up to 26.1% versus up to 2.9% (ssAAV. Replacing standard packaging plasmids by MC constructs not only allowed to reduce these contaminations below quantification limit, but in addition improved transduction efficiencies of scAAV preparations up to 30-fold. Thus, MC technology offers an easy to implement modification of standard AAV packaging protocols that significantly improves the quality of AAV vector preparations.

Leishmaniasis vector behaviour in Kenya

International Nuclear Information System (INIS)

Mutinga, M.J.

1980-01-01

Leishmaniasis in Kenya exists in two forms: cutaneous and visceral. The vectors of visceral leishmaniasis have been the subject of investigation by various researchers since World War II, when the outbreak of the disease was first noticed. The vectors of cutaneous leishmaniasis were first worked on only a decade ago after the discovery of the disease focus in Mt. Elgon. The vector behaviour of these diseases, namely Phlebotomus pedifer, the vector of cutaneous leishmaniasis, and Phlebotomus martini, the vector of visceral leishmaniasis, are discussed in detail. P. pedifer has been found to breed and bite inside caves, whereas P. martini mainly bites inside houses. (author)

A stable RNA virus-based vector for citrus trees

International Nuclear Information System (INIS)

Folimonov, Alexey S.; Folimonova, Svetlana Y.; Bar-Joseph, Moshe; Dawson, William O.

2007-01-01

Virus-based vectors are important tools in plant molecular biology and plant genomics. A number of vectors based on viruses that infect herbaceous plants are in use for expression or silencing of genes in plants as well as screening unknown sequences for function. Yet there is a need for useful virus-based vectors for woody plants, which demand much greater stability because of the longer time required for systemic infection and analysis. We examined several strategies to develop a Citrus tristeza virus (CTV)-based vector for transient expression of foreign genes in citrus trees using a green fluorescent protein (GFP) as a reporter. These strategies included substitution of the p13 open reading frame (ORF) by the ORF of GFP, construction of a self-processing fusion of GFP in-frame with the major coat protein (CP), or expression of the GFP ORF as an extra gene from a subgenomic (sg) mRNA controlled either by a duplicated CTV CP sgRNA controller element (CE) or an introduced heterologous CE of Beet yellows virus. Engineered vector constructs were examined for replication, encapsidation, GFP expression during multiple passages in protoplasts, and for their ability to infect, move, express GFP, and be maintained in citrus plants. The most successful vectors based on the 'add-a-gene' strategy have been unusually stable, continuing to produce GFP fluorescence after more than 4 years in citrus trees

Learning with LOGO: Logo and Vectors.

Science.gov (United States)

Lough, Tom; Tipps, Steve

1986-01-01

This is the first of a two-part series on the general concept of vector space. Provides tool procedures to allow investigation of vector properties, vector addition and subtraction, and X and Y components. Lists several sources of additional vector ideas. (JM)

GOOD AND EVIL AS VECTORS OF FREE WILL IN THE STRUCTURE OF ANTHROPIC TIME

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V. B. Khanzhy

2017-12-01

Full Text Available Purpose. The work is aimed at comprehending good and evil as vectors of free will in the structure of anthropic time. Methodology. The study is based on: 1 the general theory of systems (A. I. Uyomov, A. Yu. Tsofnas, L. N. Terentyeva – while justifying the possibility of representing the anthropic time as a system in general; 2 synergetics – while considering the anthropic time as a complex self-organizing system; 3 the concept of «а whole in a whole» (I. V. Yershova-Babenko – while identifying the optimal principle of correlation of the time units, taking into attention their ethical multi-vectority. Originality. In the context of the reconstruction of the concept of anthropic time: 1 the authors revealed ethical vectors of expansion of free will as the driving principle of human temporality (the vectors of «freedom for good» and «freedom for evil»; 2 the authors justified the optimality of using the principle of complementarity in solving the problem of harmonizing the coexistence of units of anthropic time («matryoshkas of time». Conclusion. 1 In a line with the tradition of anthropologization of the problem of good and evil, these intentions of human activity are interpreted as vectors of free will in the structure of anthropic time; 2 the paper represented anthropic time as a system in general (based on the general theory of systems and as a complex self-organizing system in particular (based on a synergetic methodology; 3 constituting of the system of anthropic time by the existential-actionable concept allowed to overcome the position of the one-vectored time, i.e.to reveal the ethical binarity of the anthropic time vectors prepared by the duality of expansion of free will as its driving principle; 4 formulation of the problem of discrepancy between the intentions of different temporal systems showed the optimality of the complementarity principle in solving the question how to harmonize the relations of anthropic time

Topological invariants and the dynamics of an axial vector torsion field

International Nuclear Information System (INIS)

Drechsler, W.

1983-01-01

A generalized throry of gravitation is discussed which is based on a Riemann-Cartan space-time, U 4 , with an axial vector torsion field. Besides Einstein's equations determining the metric of the U 4 a system of nonlinear field equations is established coupling an axial vector source current to the axial vector torsion field. The properties of the solutions of these equations are discussed assuming a London-type condition relating the axial current and torsion field. To characterize the solutions use is made of the Euler and Pontrjagin forms and the associated quadratic curvature invariants for the U 4 space-time. It is found that there exists for a Riemann-Cartan space-time a relation between the zeros of the axial vector torsion field and the singularities of the Pontrjagin invariant, which is analogous to the well-known Hopf relation between the zeros of vector fields and the Euler characteristic. (author)

Malaria in Kakuma refugee camp, Turkana, Kenya: facilitation of Anopheles arabiensis vector populations by installed water distribution and catchment systems

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Cetron Martin S

2011-06-01

Full Text Available Abstract Background Malaria is a major health concern for displaced persons occupying refugee camps in sub-Saharan Africa, yet there is little information on the incidence of infection and nature of transmission in these settings. Kakuma Refugee Camp, located in a dry area of north-western Kenya, has hosted ca. 60,000 to 90,000 refugees since 1992, primarily from Sudan and Somalia. The purpose of this study was to investigate malaria prevalence and attack rate and sources of Anopheles vectors in Kakuma refugee camp, in 2005-2006, after a malaria epidemic was observed by staff at camp clinics. Methods Malaria prevalence and attack rate was estimated from cases of fever presenting to camp clinics and the hospital in August 2005, using rapid diagnostic tests and microscopy of blood smears. Larval habitats of vectors were sampled and mapped. Houses were sampled for adult vectors using the pyrethrum knockdown spray method, and mapped. Vectors were identified to species level and their infection with Plasmodium falciparum determined. Results Prevalence of febrile illness with P. falciparum was highest among the 5 to 17 year olds (62.4% while malaria attack rate was highest among the two to 4 year olds (5.2/1,000/day. Infected individuals were spatially concentrated in three of the 11 residential zones of the camp. The indoor densities of Anopheles arabiensis, the sole malaria vector, were similar during the wet and dry seasons, but were distributed in an aggregated fashion and predominantly in the same zones where malaria attack rates were high. Larval habitats and larval populations were also concentrated in these zones. Larval habitats were man-made pits of water associated with tap-stands installed as the water delivery system to residents with year round availability in the camp. Three percent of A. arabiensis adult females were infected with P. falciparum sporozoites in the rainy season. Conclusions Malaria in Kakuma refugee camp was due mainly

Landslide susceptibility mapping using support vector machine and ...

Indian Academy of Sciences (India)

the prediction rate methods, the validation process was performed by ... support vector machine (SVM); geographical information systems (GIS); ... 2012a), decision tree methods (Akgun .... gence or divergence of water during downhill flow.

Multi-agent systems in epidemiology: a first step for computational biology in the study of vector-borne disease transmission

Directory of Open Access Journals (Sweden)

Guégan Jean-François

2008-10-01

Full Text Available Abstract Background Computational biology is often associated with genetic or genomic studies only. However, thanks to the increase of computational resources, computational models are appreciated as useful tools in many other scientific fields. Such modeling systems are particularly relevant for the study of complex systems, like the epidemiology of emerging infectious diseases. So far, mathematical models remain the main tool for the epidemiological and ecological analysis of infectious diseases, with SIR models could be seen as an implicit standard in epidemiology. Unfortunately, these models are based on differential equations and, therefore, can become very rapidly unmanageable due to the too many parameters which need to be taken into consideration. For instance, in the case of zoonotic and vector-borne diseases in wildlife many different potential host species could be involved in the life-cycle of disease transmission, and SIR models might not be the most suitable tool to truly capture the overall disease circulation within that environment. This limitation underlines the necessity to develop a standard spatial model that can cope with the transmission of disease in realistic ecosystems. Results Computational biology may prove to be flexible enough to take into account the natural complexity observed in both natural and man-made ecosystems. In this paper, we propose a new computational model to study the transmission of infectious diseases in a spatially explicit context. We developed a multi-agent system model for vector-borne disease transmission in a realistic spatial environment. Conclusion Here we describe in detail the general behavior of this model that we hope will become a standard reference for the study of vector-borne disease transmission in wildlife. To conclude, we show how this simple model could be easily adapted and modified to be used as a common framework for further research developments in this field.

Measuring magnetic field vector by stimulated Raman transitions

International Nuclear Information System (INIS)

Wang, Wenli; Wei, Rong; Lin, Jinda; Wang, Yuzhu; Dong, Richang; Zou, Fan; Chen, Tingting

2016-01-01

We present a method for measuring the magnetic field vector in an atomic fountain by probing the line strength of stimulated Raman transitions. The relative line strength for a Λ-type level system with an existing magnetic field is theoretically analyzed. The magnetic field vector measured by our proposed method is consistent well with that by the traditional bias magnetic field method with an axial resolution of 6.1 mrad and a radial resolution of 0.16 rad. Dependences of the Raman transitions on laser polarization schemes are also analyzed. Our method offers the potential advantages for magnetic field measurement without requiring additional bias fields, beyond the limitation of magnetic field intensity, and extending the spatial measurement range. The proposed method can be widely used for measuring magnetic field vector in other precision measurement fields.

Student difficulties regarding symbolic and graphical representations of vector fields

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Laurens Bollen

2017-08-01

Full Text Available The ability to switch between various representations is an invaluable problem-solving skill in physics. In addition, research has shown that using multiple representations can greatly enhance a person’s understanding of mathematical and physical concepts. This paper describes a study of student difficulties regarding interpreting, constructing, and switching between representations of vector fields, using both qualitative and quantitative methods. We first identified to what extent students are fluent with the use of field vector plots, field line diagrams, and symbolic expressions of vector fields by conducting individual student interviews and analyzing in-class student activities. Based on those findings, we designed the Vector Field Representations test, a free response assessment tool that has been given to 196 second- and third-year physics, mathematics, and engineering students from four different universities. From the obtained results we gained a comprehensive overview of typical errors that students make when switching between vector field representations. In addition, the study allowed us to determine the relative prevalence of the observed difficulties. Although the results varied greatly between institutions, a general trend revealed that many students struggle with vector addition, fail to recognize the field line density as an indication of the magnitude of the field, confuse characteristics of field lines and equipotential lines, and do not choose the appropriate coordinate system when writing out mathematical expressions of vector fields.

Student difficulties regarding symbolic and graphical representations of vector fields

Science.gov (United States)

Bollen, Laurens; van Kampen, Paul; Baily, Charles; Kelly, Mossy; De Cock, Mieke

2017-12-01

The ability to switch between various representations is an invaluable problem-solving skill in physics. In addition, research has shown that using multiple representations can greatly enhance a person's understanding of mathematical and physical concepts. This paper describes a study of student difficulties regarding interpreting, constructing, and switching between representations of vector fields, using both qualitative and quantitative methods. We first identified to what extent students are fluent with the use of field vector plots, field line diagrams, and symbolic expressions of vector fields by conducting individual student interviews and analyzing in-class student activities. Based on those findings, we designed the Vector Field Representations test, a free response assessment tool that has been given to 196 second- and third-year physics, mathematics, and engineering students from four different universities. From the obtained results we gained a comprehensive overview of typical errors that students make when switching between vector field representations. In addition, the study allowed us to determine the relative prevalence of the observed difficulties. Although the results varied greatly between institutions, a general trend revealed that many students struggle with vector addition, fail to recognize the field line density as an indication of the magnitude of the field, confuse characteristics of field lines and equipotential lines, and do not choose the appropriate coordinate system when writing out mathematical expressions of vector fields.

Direct vector controlled six-phase asymmetrical induction motor with power balanced space vector PWM multilevel operation

DEFF Research Database (Denmark)

Padmanaban, Sanjeevi Kumar; Grandi, Gabriele; Ojo, Joseph Olorunfemi

2016-01-01

In this paper, a six-phase (asymmetrical) machine is investigated, 300 phase displacement is set between two three-phase stator windings keeping deliberately in open-end configuration. Power supply consists of four classical three-phase voltage inverters (VSIs), each one connected to the open......-winding terminals. An original synchronous field oriented control (FOC) algorithm with three variables as degree of freedom is proposed, allowing power sharing among the four VSIs in symmetric/asymmetric conditions. A standard three-level space vector pulse width modulation (SVPWM) by nearest three vector (NTV......) approach was adopted for each couple of VSIs to operate as multilevel output voltage generators. The proposed power sharing algorithm is verified for the ac drive system by observing the dynamic behaviours in different set conditions by complete simulation modelling in software (Matlab...

Hybrid Lentivirus-transposon Vectors With a Random Integration Profile in Human Cells

DEFF Research Database (Denmark)

Staunstrup, Nicklas H; Moldt, Brian; Mátés, Lajos

2009-01-01

Gene delivery by human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) is efficient, but genomic integration of the viral DNA is strongly biased toward transcriptionally active loci resulting in an increased risk of insertional mutagenesis in gene therapy protocols. Nonviral...... Sleeping Beauty (SB) transposon vectors have a significantly safer insertion profile, but efficient delivery into relevant cell/tissue types is a limitation. In an attempt to combine the favorable features of the two vector systems we established a novel hybrid vector technology based on SB transposase......-mediated insertion of lentiviral DNA circles generated during transduction of target cells with integrase (IN)-defective LVs (IDLVs). By construction of a lentivirus-transposon hybrid vector allowing transposition exclusively from circular viral DNA substrates, we demonstrate that SB transposase added in trans...

Strangeness Vector and Axial-Vector Form Factors of the Nucleon

Directory of Open Access Journals (Sweden)

Pate Stephen

2014-03-01

Full Text Available A revised global fit of electroweak ep and vp elastic scattering data has been performed, with the goal of determining the strange quark contribution to the vector and axial-vector form factors of the nucleon in the momentum-transfer range 0 < Q2 < 1 GeV2. The two vector (electric and magnetic form factors GsE(Q2 and GsM(Q2 are strongly constrained by ep elastic scattering data, while the major source of information on the axial-vector form factor GsA(Q2 is vp scattering data. Combining the two kinds of data into a single global fit makes possible additional precision in the determination of these form factors, and provides a unique way to determine the strange quark contribution to the nucleon spin, ΔS , independently of leptonic deep-inelastic scattering. The fit makes use of data from the BNL-E734, SAMPLE, HAPPEx, G0, and PVA4 experiments; we will also compare the result of the fit with recent data from MiniBooNE, and anticipate how this fit can be improved when new data from MicroBooNE become available.

Vectorization of DOT3.5 code

International Nuclear Information System (INIS)

Nonomiya, Iwao; Ishiguro, Misako; Tsutsui, Tsuneo

1990-07-01

In this report, we describe the vectorization of two-dimensional Sn-method radiation transport code DOT3.5. Vectorized codes are not only the NEA original version developed at ORNL but also the versions improved by JAERI: DOT3.5 FNS version for fusion neutronics analyses, DOT3.5 FER version for fusion reactor design, and ESPRIT module of RADHEAT-V4 code system for radiation shielding and radiation transport analyses. In DOT3.5, input/output processing time amounts to a great part of the elapsed time when a large number of energy groups and/or a large number of spatial mesh points are used in the calculated problem. Therefore, an improvement has been made for the speedup of input/output processing in the DOT3.5 FNS version, and DOT-DD (Double Differential cross section) code. The total speedup ratio of vectorized version to the original scalar one is 1.7∼1.9 for DOT3.5 NEA version, 2.2∼2.3 fro DOT3.5 FNS version, 1.7 for DOT3.5 FER version, and 3.1∼4.4 for RADHEAT-V4, respectively. The elapsed times for improved DOT3.5 FNS version and DOT-DD are reduced to 50∼65% that of the original version by the input/output speedup. In this report, we describe summary of codes, the techniques used for the vectorization and input/output speedup, verification of computed results, and speedup effect. (author)

Multi-task Vector Field Learning.

Science.gov (United States)

Lin, Binbin; Yang, Sen; Zhang, Chiyuan; Ye, Jieping; He, Xiaofei

2012-01-01

Multi-task learning (MTL) aims to improve generalization performance by learning multiple related tasks simultaneously and identifying the shared information among tasks. Most of existing MTL methods focus on learning linear models under the supervised setting. We propose a novel semi-supervised and nonlinear approach for MTL using vector fields. A vector field is a smooth mapping from the manifold to the tangent spaces which can be viewed as a directional derivative of functions on the manifold. We argue that vector fields provide a natural way to exploit the geometric structure of data as well as the shared differential structure of tasks, both of which are crucial for semi-supervised multi-task learning. In this paper, we develop multi-task vector field learning (MTVFL) which learns the predictor functions and the vector fields simultaneously. MTVFL has the following key properties. (1) The vector fields MTVFL learns are close to the gradient fields of the predictor functions. (2) Within each task, the vector field is required to be as parallel as possible which is expected to span a low dimensional subspace. (3) The vector fields from all tasks share a low dimensional subspace. We formalize our idea in a regularization framework and also provide a convex relaxation method to solve the original non-convex problem. The experimental results on synthetic and real data demonstrate the effectiveness of our proposed approach.

Bevacizumab Exacerbates Paclitaxel-Induced Neuropathy: A Retrospective Cohort Study.

Directory of Open Access Journals (Sweden)

Ayumu Matsuoka

Full Text Available Bevacizumab (BEV, a humanized anti-vascular endothelial growth factor (VEGF monoclonal antibody, enhances the antitumor effectiveness of paclitaxel (PTX-based chemotherapy in many metastatic cancers. A recent study in mice showed that VEGF receptor inhibitors can interfere with the neuroprotective effects of endogenous VEGF, potentially triggering the exacerbation of PTX-induced neuropathy. In clinical trials, exacerbation of neuropathy in patients who received PTX combined with BEV (PTX+BEV has generally been explained by increased exposure to PTX owing to the extended duration of chemotherapy. We investigated whether the concurrent use of BEV is associated with the exacerbation of PTX-induced neuropathy.Female patients with breast cancer who had received weekly PTX or PTX+BEV from September 2011 through May 2016 were studied retrospectively. PTX-induced neuropathy was evaluated at the same time points (at the 6th and 12th courses of chemotherapy in both cohorts. A multivariate Cox proportional-hazards model was used to assess the independent effect of BEV on the time to the onset of neuropathy.A total of 107 patients (median age, 55 years; range, 32-83 were studied. Sixty-one patients received PTX as adjuvant chemotherapy, 23 received PTX for metastatic disease, and 23 received PTX+BEV for metastatic disease. Peripheral sensory neuropathy was worse in patients who received PTX+BEV than in those who received PTX alone: at the 6th course, Grade 0/1/2/3 = 4/13/4/0 vs. 25/42/6/0 (P = 0.095; at the 12th course, 2/3/11/3 vs. 7/30/23/2 (P = 0.016. At the 12th course, the incidence of Grade 2 or higher neuropathy was significantly higher in patients treated with PTX+BEV than in those treated with PTX alone (74% vs. 40%; P = 0.017. In multivariate analysis, BEV was significantly associated with an increased risk of neuropathy (HR 2.32, 95% CI 1.21-4.44, P = 0.012.The concurrent use of BEV could worsen PTX-induced neuropathy in patients with breast

An evaluation method of cross-type H-coil angle for accurate two-dimensional vector magnetic measurement

International Nuclear Information System (INIS)

Maeda, Yoshitaka; Todaka, Takashi; Shimoji, Hiroyasu; Enokizono, Masato; Sievert, Johanes

2006-01-01

Recently, two-dimensional vector magnetic measurement has become popular and many researchers concerned with this field have attracted to develop more accurate measuring systems and standard measurement systems. Because the two-dimensional vector magnetic property is the relationship between the magnetic flux density vector B and the magnetic field strength vector H , the most important parameter is those components. For the accurate measurement of the field strength vector, we have developed an evaluation apparatus, which consists of a standard solenoid coil and a high-precision turntable. Angle errors of a double H-coil (a cross-type H-coil), which is wound one after the other around a former, can be evaluated with this apparatus. The magnetic field strength is compensated with the measured angle error

Optimal Routing and Scheduling of Charge for Electric Vehicles: Case Study

OpenAIRE

Barco, John; Guerra, Andres; Muñoz, Luis; Quijano, Nicanor

2013-01-01

In Colombia, there is an increasing interest about improving public transportation. One of the proposed strategies in that way is the use battery electric vehicles (BEVs). One of the new challenges is the BEVs routing problem, which is subjected to the traditional issues of the routing problems, and must also consider the particularities of autonomy, charge and battery degradation of the BEVs. In this work, a scheme that coordinates the routing, scheduling of charge and operating costs of BEV...

Enhancing poxvirus vectors vaccine immunogenicity.