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Sample records for vavilov-cherenkov radiation arising

  1. The mechanism of Vavilov-Cherenkov radiation

    Science.gov (United States)

    Kobzev, A. P.

    2010-05-01

    The mechanism of generation of Vavilov-Cherenkov radiation is discussed in this article. The developers of the theory of the Vavilov-Cherenkov effect, I.E. Tamm and I.M. Frank, attributed this effect to their discovery of a new mechanism of radiation when a charged particle moves uniformly and rectilinearly in the medium. As such a mechanism presupposes the violation of the laws of conservation of energy and momentum, they proposed the abolition of these laws to account for the Vavilov-Cherenkov radiation mechanism. This idea has received a considerably wide acceptance in the creation of other theories, for example, transition radiation theory. In this paper, the radiation mechanism for the charge constant motion is demonstrated to be incorrect, because it contradicts not only the laws of conservation of energy and momentum, but also the very definitions of uniform and rectilinear motion (Newton's First Law). A consistent explanation of the Vavilov-Cherenkov radiation microscopic mechanism that does not contradict the basic laws is proposed. It is shown that the radiation arises from the interaction of the moving charge with bound charges that are spaced fairly far away from its trajectory. The Vavilov-Cherenkov radiation mechanism bears a slowing down character, but it differs fundamentally from bremsstrahlung, primarily because the Vavilov-Cherenkov radiation onset results from a two-stage process. First, the moving particle polarizes the medium; then, the already polarized atoms radiate coherently, provided that the particle velocity exceeds the phase speed of light in the medium. If the particle velocity is less than the phase speed of light in the medium, the polarized atoms return energy to the outgoing particle. In this case, radiation is not observed. Special attention is given to the relatively constant particle velocity as the condition of the coherent composition of waves. However, its motion cannot be designated as a uniform and rectilinear one in the

  2. Vavilov-Cherenkov and Synchrotron Radiation Foundations and Applications

    CERN Document Server

    Afanasiev, G. N

    2005-01-01

    The theory of the Vavilov-Cherenkov radiation observed by Cherenkov in 1934 was created by Tamm, Frank and Ginsburg who associated the observed blue light with the uniform charge motion of a charge at a velocity greater than the velocity of light in the medium. On the other hand, Vavilov, Cherenkov's teacher, attributed the observed blue light to the deceleration of electrons. This has given rise to the appearance of papers in which the radiation of a charge uniformly moving in a finite space interval was related to the Bremsstrahlung arising at the end points of the motion interval. This monograph is intended for students of the third year and higher, for postgraduates, for professional scientists (both experimentalists and theoreticians) dealing with Vavilov-Cherenkov and synchrotron radiation. An acquaintance with the three volumes of the Landau and Lifshitz course (Quantum Mechanics, Classical Field Theory and Macroscopic Electrodynamics) is sufficient for understanding the text.

  3. Radiation of superluminal sources in vacuum

    Energy Technology Data Exchange (ETDEWEB)

    Bolotovskii, B.M. [P.N. Lebedev Physical Institute, Leninsky prospect 53, Moscow 119991 (Russian Federation)]. E-mail: bolot@lpi.ru; Serov, A.V. [P.N. Lebedev Physical Institute, Leninsky prospect 53, Moscow 119991 (Russian Federation)]. E-mail: serov@x4u.levedev.ru

    2006-08-15

    Vavilov-Cherenkov radiation is emitted by a charged body uniformly moving in a medium when the body velocity exceeds that of light in the medium. Therefore, it was believed that Vavilov-Cherenkov radiation is impossible in vacuum, because the velocity of any material body cannot exceed the light velocity in vacuum. However, it is possible to realize distributions of charges and currents which propagate with any given velocity. Such a superluminal distribution can be used as a source of Vavilov-Cherenkov radiation in vacuum.

  4. Transient radiation in an anisotropic magnetodielectric plate in a waveguide

    Science.gov (United States)

    Gevorkyan, E. A.

    2017-02-01

    We have considered transient radiation of a charged particle in an anisotropic magnetodielectric plate placed into a regular waveguide. It is assumed that the charged particle passes through the plate moving at a constant velocity perpendicularly to the waveguide axis. Wave equations and analytical expressions for transverse electric (TE) and transverse magnetic (TM) fields in different regions of the waveguide have been obtained. Energies of transient radiation of the moving particle have been calculated. The properties of transient radiation and Vavilov-Cherenkov radiation have been analyzed for the case of a rectangular waveguide. Energies of transient radiation have been calculated for the case of a "thin" plate in the waveguide, when the wavelength in the plate is much greater than the length of the plate.

  5. Two cases of basal cell carcinoma arising from chronic radiation dermatitis

    Energy Technology Data Exchange (ETDEWEB)

    Wakamori, Takeshi; Takenaka, Hideya; Ueda, Eiichiro; Katoh, Norito; Kishimoto, Saburo [Kyoto Prefectural Univ. of Medicine (Japan)

    2003-04-01

    A 48-year-old female and a 51-year-old male with basal cell carcinoma (BCC) arising from chronic radiation dermatitis are reviewed. They are treated with radiotherapy for hemangioma on their right cheek in their childhood. Review in the literature showed high incidence of the histological diagnosis of malignant skin tumors arising from chronic radiation dermatitis are follows: squamous cell carcinoma (SCC), BCC, sarcoma, and Bowen's disease. (author)

  6. Guidance notes for the protection of persons against ionising radiations arising from veterinary use

    Energy Technology Data Exchange (ETDEWEB)

    Bland, W.F.

    1988-05-01

    New Guidance Notes for the protection of persons against ionizing radiations arising from veterinary use have been prepared by the NRPB and the Health and Safety Executive. A brief article outlines the main changes made to the 1983 Guidance Notes in updating to the New Guidance Notes. (U.K.).

  7. SCC, Bowen's disease and BCC arising on chronic radiation dermatitis due to radiation therapy for tinea pedis

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, Eri; Aoki, Mikako; Ikemura, Akiko; Igarashi, Tsukasa; Suzuki, Kayano; Kawana, Seiji [Nippon Medical School, Tokyo (Japan). Hospital

    2000-05-01

    We reported a case who developed three different types of skin cancers: SCC, BCC, and Bowen's disease, on the chronic radiation dermatitis. He had been treated for his tinea pedis et palmaris with radiotherapy in 1940's. It is very ratre that three different types of skin cancers arise in the same patient. This is a second case reported in Japan. (author)

  8. Radiation of a uniformly moving line charge in a zero-index metamaterial and other periodic media.

    Science.gov (United States)

    Yanai, Avner; Levy, Uriel

    2012-07-30

    Radiation of electromagnetic waves by a uniformly moving charge is the subject of extensive research over the last several decades. Fascinating effects such as Vavilov-Cherenkov radiation, transition radiation and the Smith-Purcell effect were discovered and studied in depth. In this letter we study the radiation of a line charge moving with relativistic constant velocity within an average zero index metamaterial consisting of periodically alternating layers with negative and positive refractive index. We observe a strong radiation enhancement, ~3 orders of magnitude, for specific combinations of velocities and radiation frequencies. This surprising finding is attributed to a gigantic increase in the density of states at the positive/negative index boundary. Furthermore, we shed light on radiation effects of such a line charge propagating within the more "traditional" structure of periodically alternating layers consisting of positive and different refractive index with focus on frequencies satisfying the quarter wave stack and the half wave stack conditions. We show that the quarter-wave-stack case results in emission propagating vertically to the line charge trajectory, while the half-wave-stack results in negligible radiation. All these findings were obtained using a computationally efficient and conceptually intuitive computation method, based on eigenmode expansion of specific frequency components. For validation purposes this method was compared with the finite-difference-time-domain method.

  9. Radiative Impact of Arctic Stratus Over Varying Sea Ice Conditions During ARISE

    Science.gov (United States)

    Bucholtz, A.; Schmidt, S.; Chen, H.; Moore, R.; Reid, E. A.

    2016-12-01

    We present measurements of the solar and infrared radiative heating rates of Arctic stratus sampled by the NASA C130 aircraft during the Arctic Radiation-IceBridge Sea and Ice Experiment (ARISE) in September 2014. Measurements of the up- and down-welling broadband solar irradiance, broadband infrared irradiance, and spectral solar irradiance, combined with measurements of the downwelling diffuse broadband solar irradiance are used to characterize the radiative impact of the stratus. Heating rates are directly determined from the divergence of the net irradiance measurements with altitude and indirectly from cloud microphysical measurements (ice and liquid water content, cloud droplet number and size distribution) in a closure type study. In particular, we will present results from the flight on September 19, 2014 where the aircraft sampled a low level stratus deck overlying a distinct gradient in sea ice conditions, from open ocean to solid ice pack, that provided a unique opportunity to quantify the impact of surface conditions on the radiative properties of Arctic stratus.

  10. Chondrosarcoma arising within a radiation-induced osteochondroma several years following childhood total body irradiation: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Nagata, Shuji [Kurume University Hospital, Department of Radiology, Fukuoka (Japan); Shen, Robert K. [Mayo Clinic, Department of Surgery, Rochester, MN (United States); Laack, Nadia N. [Mayo Clinic, Department of Radiation Oncology, Rochester, MN (United States); Inwards, Carrie Y. [Mayo Clinic, Department of Pathology, Rochester, MN (United States); Wenger, Doris E.; Amrami, Kimberly K. [Mayo Clinic, Department of Radiology, Rochester, MN (United States)

    2013-08-15

    Malignant degeneration arising in radiation-induced osteochondromas is extremely rare. We report a case of a 34-year-old man with a chondrosarcoma arising from an osteochondroma of the left posterior eighth rib that developed following total body irradiation received as part of the conditioning regimen prior to bone marrow transplantation at age 8. To our knowledge, this is only the fourth reported case of a chondrosarcoma arising within a radiation-induced osteochondroma and the first case occurring following childhood total body irradiation. (orig.)

  11. Panhypopituitarism arising after radiation therapy for germinoma in the suprasellar region. Case report

    Energy Technology Data Exchange (ETDEWEB)

    Maeyama, Masataka; Toribe, Yasuhisa; Adachi, Kouichi; Arita, Kouji [Itami Municipal Hospital, Hyogo (Japan)

    1995-01-01

    A case is presented in which panhypopituitarism occurred in an 8-year-old girl after radiation therapy for germinoma in the suprasellar region. The patient was referred to the hospital because of polydipsia and polyhydruria. She was diagnosed as having pituitary diabetes insipidus by water limitation test. Cranial CT and MRI revealed germinoma in the suprasellar region. Tumor cells were remarkably reduced by tentative irradiation. Thus the patient was treated with whole-body irradiation. Subsequently, she had general fatigue, loss of appetite, and activity decrease. The reaction to TRH test was low. ACTH secretion insufficiency was revealed by insulin test. The patient developed panhypopituitarism associated with GH and ADH secretion insufficiency. She has been managed on hormonal therapy, including DDAVP, hydrocortisone, and Levothyroxine. Although germinoma is highly sensitive to radiation, a long-term follow up is required because of the potential occurrence of postoperative sequelae. (N.K.).

  12. Guidance notes for the protection of persons against ionising radiations arising from veterinary use

    Energy Technology Data Exchange (ETDEWEB)

    1988-01-01

    These notes are not intended to provide detailed guidance on all the conditions that apply to veterinary practice but rather to indicate the types of arrangements which should be employed in order to comply with the main requirements of the Regulations. They also aim to establish a pattern by which good radiological practice can be achieved and radiation doses to veterinary surgeons, radiographic staff, and anyone else involved, minimised.

  13. The effect of steroids for the treatment of delayed urological involvement arising from radiation therapy; A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kawano, Shinichi; Tasaki, Yoshihisa; Fukunaga, Yoshikazu (Oita National Hospital (Japan))

    1992-07-01

    A 55-year-old woman visited our hospital with the chief complaint of high fever. She had received whole pelvic radiation therapy following radical hysterectomy 22 years earlier. Excretory urography revealed bilateral severe hydrone phrosis. Urological examinations were carried out. Urethral stricture and marked small bladder were found. This case was diagnosed as delayed urological involvement arising from radiation therapy complicated with neurogenic bladder. Prednisolone at a total dose of 1,060 mg was administered over 51 days under indwelling catheters to the urethra and to both ureters. The function of the urinary bladder has been maintained at an improved level over a period of 2 months following the removal of the ureteral and urethral catheters. (author).

  14. UV-B radiation arising from stratospheric ozone depletion influences the pigmentation of the Antarctic moss Andreaea regularis.

    Science.gov (United States)

    Newsham, K K

    2003-05-01

    Changes to the radiative environment arising from stratospheric ozone (O(3)) depletion and subsequent associations between these changes and the pigmentation of the moss Andreaea regularis were measured in late austral spring and early summer 1998 at Rothera Point on the western Antarctic Peninsula (67 degrees S, 68 degrees W). A strong relationship between O(3) column depth and the ratio of UV-B to PAR irradiance ( F(uv-b)/ F(par)) was recorded at ground level ( r(2)=92%, Pdepletion. The data derived from this study suggest that changes to the radiative environment associated with stratospheric O(3) depletion influence the pigmentation of A. regularis. As a corollary, flavonoids are shown to be present in tissues of A. regularis.

  15. Microcystic adnexal carcinoma arising in the setting of previous radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Antley, C.A. [Univ. of Arkansas for Medical Sciences, Dept. of Pathology, Little Rock, Arkansas (United States); Carney, M.; Smoller, B.R. [Univ. of Arkansas for Medical Sciences, Dept. of Dermatology, Little Rock, Arkansas (United States)

    1999-01-01

    While there are several reports of microcystic adnexal carcinoma developing in patients within sites of previous therapeutic irradiation, this relationship is not well described in the dermatological literature. We report a case of 42-year-old man with a remote history of therapeutic irradiation following surgical resection of periorbital rhabdomyosarcoma. Subsequently, he developed multiple basal cell carcinomas and a microcystic adnexal carcinoma within the field of irradiation. The histologic features were those of a classic microcystic adnexal carcinoma, with well differentiated nests and cords of keratinocytes displaying follicular and ductular differentiation infiltrating diffusely into the reticular dermis. Dense fibrosis was present surrounding the neoplastic keratinocytes. Nuclear atypia and mitotic figures were not identified. A carcinoembryonic antigen (CEA) stain demonstrated glandular differentiation. It is important for dermatologists to be aware of the apparent relationship between the rare microcystic adnexal carcinoma with its innocuous scar-like clinical appearance and prior local radiation therapy. (au) 11 refs.

  16. Megavolt parallel potentials arising from double-layer streams in the Earth's outer radiation belt.

    Science.gov (United States)

    Mozer, F S; Bale, S D; Bonnell, J W; Chaston, C C; Roth, I; Wygant, J

    2013-12-06

    Huge numbers of double layers carrying electric fields parallel to the local magnetic field line have been observed on the Van Allen probes in connection with in situ relativistic electron acceleration in the Earth's outer radiation belt. For one case with adequate high time resolution data, 7000 double layers were observed in an interval of 1 min to produce a 230,000 V net parallel potential drop crossing the spacecraft. Lower resolution data show that this event lasted for 6 min and that more than 1,000,000 volts of net parallel potential crossed the spacecraft during this time. A double layer traverses the length of a magnetic field line in about 15 s and the orbital motion of the spacecraft perpendicular to the magnetic field was about 700 km during this 6 min interval. Thus, the instantaneous parallel potential along a single magnetic field line was the order of tens of kilovolts. Electrons on the field line might experience many such potential steps in their lifetimes to accelerate them to energies where they serve as the seed population for relativistic acceleration by coherent, large amplitude whistler mode waves. Because the double-layer speed of 3100  km/s is the order of the electron acoustic speed (and not the ion acoustic speed) of a 25 eV plasma, the double layers may result from a new electron acoustic mode. Acceleration mechanisms involving double layers may also be important in planetary radiation belts such as Jupiter, Saturn, Uranus, and Neptune, in the solar corona during flares, and in astrophysical objects.

  17. Non-relativistic limit of the compressible Navier-Stokes-Fourier-P1 approximation model arising in radiation hydrodynamics

    OpenAIRE

    Jiang, Song; Li, Fucai; Xie, Feng

    2015-01-01

    As is well-known that the general radiation hydrodynamics models include two mainly coupled parts: one is macroscopic fluid part, which is governed by the compressible Navier-Stokes-Fourier equations, another is radiation field part, which is described by the transport equation of photons. Under the two physical approximations: "gray" approximation and P1 approximation, one can derive the so-called Navier-Stokes-Fourier-P1 approximation radiation hydrodynamics model from the general one. In t...

  18. Superluminal motion (review)

    Science.gov (United States)

    Malykin, G. B.; Romanets, E. A.

    2012-06-01

    Prior to the development of Special Relativity, no restrictions were imposed on the velocity of the motion of particles and material bodies, as well as on energy transfer and signal propagation. At the end of the 19th century and the beginning of the 20th century, it was shown that a charge that moves at a velocity faster than the speed of light in an optical medium, in particular, in vacuum, gives rise to impact radiation, which later was termed the Vavilov-Cherenkov radiation. Shortly after the development of Special Relativity, some researchers considered the possibility of superluminal motion. In 1923, the Soviet physicist L.Ya. Strum suggested the existence of tachyons, which, however, have not been discovered yet. Superluminal motions can occur only for images, e.g., for so-called "light spots," which were considered in 1972 by V.L. Ginzburg and B.M. Bolotovskii. These spots can move with a superluminal phase velocity but are incapable of transferring energy and information. Nevertheless, these light spots may induce quite real generation of microwave radiation in closed waveguides and create the Vavilov-Cherenkov radiation in vacuum. In this work, we consider various paradoxes, illusions, and artifacts associated with superluminal motion.

  19. Eletromagnetic radiation and the mechanical reactions arising from it

    CERN Document Server

    Schott, G A

    1912-01-01

    Fundamental equations of the electron theory ; transformation of the potentials ; other types of solution ; physical interpretation of the solutions obtained ; illustrative examples ; remarks on the solutions obtained and on the methods of calculating the potentials in general ; periodic motions ; on the distant field due to a moving charge ; pseudo-periodic and aperiodic motions ; on the field near the orbit of a moving charge or group ; the mechanical forces acting on electric charges in motion ; the motion of groups of electric charges ; on the Doppler effect ; on the disturbed motion of a ring of electrons ; on the field close to a point charge in motion ; the mechanical force exterted by an electron on itself ; the mechanical explanation of the electron ; the mechanics of the Lorentz electron ; problems illustrative of the motion of the Lorentz electron.

  20. Hawking radiation

    Science.gov (United States)

    Parentani, Renaud; Spindel, Philippe

    2011-12-01

    Hawking radiation is the thermal radiation predicted to be spontaneously emitted by black holes. It arises from the steady conversion of quantum vacuum fluctuations into pairs of particles, one of which escaping at infinity while the other is trapped inside the black hole horizon. It is named after the physicist Stephen Hawking who derived its existence in 1974. This radiation reduces the mass of black holes and is therefore also known as black hole evaporation.

  1. Primary extradural meningioma arising from the calvarium

    Directory of Open Access Journals (Sweden)

    N Ravi

    2013-06-01

    Full Text Available Meningiomas are the most common intracranial tumours. Meningiomas arising at other locations are termed primary extradural meningiomas (EDM and are rare. Here we report a case of EDM arising from the calvarium – a primary calvarial meningioma (PCM.

  2. Cutaneous osteosarcoma arising from a burn scar

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Min A.; Yi, Jaehyuck [Kyungpook National University, Department of Radiology, College of Medicine, Daegu (Korea, Republic of); Kyungpook National University Hospital, Department of Radiology, Daegu (Korea, Republic of); Chae, Jong Min [Kyungpook National University, Department of Pathology, College of Medicine, Daegu (Korea, Republic of)

    2017-04-15

    Tumors that develop in old burn scars are usually squamous cell carcinomas. Sarcomas have also been reported, albeit rarely. To our knowledge, there has been only one case report of an extraskeletal osteosarcoma arising in a prior burn scar reported in the English-language literature, mainly discussing the clinicopathological features. Herein, we present a case of cutaneous osteosarcoma visualized as a mineralized soft-tissue mass arising from the scar associated with a previous skin burn over the back. This seems to be the first report describing the imaging features of a cutaneous osteosarcoma from an old burn scar. (orig.)

  3. Cavernous lymphangioma arising from uterine corpus.

    Science.gov (United States)

    Furui, Tatsuro; Imai, Atsushi; Yokoyama, Yasuhiro; Sato, Eriko; Tamaya, Teruhiko

    2003-07-01

    A rare case of giant uterine lymphangioma was experienced. A 44-year-old female noted a rapidly grown abdominal tumor and its accompanied symptoms, progressive abdominal distension, lumbago, and developed leg edema. Ultrasonography made a possible diagnosis of a huge ovarian tumor; postoperative diagnosis was cavernous lymphangioma arising from the uterus. According to the literature, lymphangioma itself is a rare tumor, and giant lymphangioma arising from uterine corpus is extremely rare. We experienced an extremely rare case of uterine lymphangioma and ultrasound tomography better imaged the tumor inside.

  4. ARISE: American renaissance in science education

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-14

    The national standards and state derivatives must be reinforced by models of curricular reform. In this paper, ARISE presents one model based on a set of principles--coherence, integration of the sciences, movement from concrete ideas to abstract ones, inquiry, connection and application, sequencing that is responsive to how people learn.

  5. Cellular schwannoma arising from sigmoid mesocolon presenting ...

    African Journals Online (AJOL)

    We present a case of a 58‑year‑old female with a massive twisted tumor arising from sigmoid mesocolon. The tumor was diagnosed to be a case of cellular schwannoma, an exceedingly rare tumor in this location with rare presentation. Keywords: Pelvis, Retroperitoneum, Schwannoma, Sigmoid mesocolon, Torsion, Tumor ...

  6. Cellular Schwannoma Arising from Sigmoid Mesocolon Presenting ...

    African Journals Online (AJOL)

    We present a case of a 58‑year‑old female with a massive twisted tumor arising from sigmoid mesocolon. The tumor was diagnosed to be a case of cellular schwannoma, an exceedingly rare tumor in this location with rare presentation. Keywords: Pelvis, Retroperitoneum, Schwannoma, Sigmoid mesocolon, Torsion, Tumor.

  7. Sclerosing haemangioma arising within extralobar pulmonary sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Ahmetoglu, Ali; Kosucu, Polat; Guemele, Halit Resit [Department of Radiology, Farabi Hospital, Karadeniz Technical University, 61080 Trabzon (Turkey); Imamoglu, Mustafa; Cay, Ali [Department of Paediatric Surgery, Farabi Hospital, Karadeniz Technical University, Trabzon (Turkey); Reis, Abdulkadir [Department of Pathology, Farabi Hospital, Karadeniz Technical University, Trabzon (Turkey)

    2003-09-01

    Extralobar pulmonary sequestration is a rare anomaly of abnormal pulmonary tissue without any communication to the bronchial tree. Sclerosing haemangioma is a rare lung tumour, generally seen in middle-aged women. The combination of these two rare pathologies has not been previously reported. We describe the CT and CT angiographic findings of sclerosing haemangioma arising within an extralobar pulmonary sequestration in a 2-year-old girl. (orig.)

  8. Malignant fibrous histiocytoma arising on chronic osteomyelitis.

    Science.gov (United States)

    Foti, C; Giannelli, G; Berloco, A; Mascolo, V; Ingravallo, G; Giardina, C

    2002-07-01

    We present a case of a primary malignant fibrous histiocytoma of the skin (MFH) arising on chronic osteomyelitis in a 67-year-old woman. Although this condition seems to be a predisposing factor for the onset of the malignancy, MFH complicating chronic osteomyelitis is generally localized at the level of the bone tissue. In the case we report the neoplasm was primitively localized at the dermal and subcutaneous level and presented as a rapidly growing mass.

  9. Conjunctival lymphoma arising from reactive lymphoid hyperplasia

    Directory of Open Access Journals (Sweden)

    Fukuhara Junichi

    2012-09-01

    Full Text Available Abstract Extra nodal marginal zone B-cell lymphoma (EMZL of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU. Specimens from conjunctival tumors in the right eye, oculus dexter (OD, revealed a collection of small lymphoid cells in the stroma. Immunohistochemically, immunoglobulin (Ig light chain restriction was not detected. In contrast, diffuse atypical lymphoid cell infiltration was noted in the left eye, oculus sinister (OS, and positive for CD20, a marker for B cells OS. The tumors were histologically diagnosed as RLH OD, and EMZL OS. PCR analysis detected IgH gene rearrangement in the joining region (JH region OU. After 11 months, a re-biopsy specimen demonstrated EMZL based on compatible pathological and genetic findings OD, arising from RLH. This case suggests that even if the diagnosis of the conjunctival lymphoproliferative lesions is histologically benign, confirmation of the B-cell clonality by checking IgH gene rearrangement should be useful to predict the incidence of malignancy.

  10. Eccrine Poroma Arising within Nevus Sebaceous

    Directory of Open Access Journals (Sweden)

    Natnicha Girdwichai

    2016-04-01

    Full Text Available Nevus sebaceous is a congenital, benign hamartomatous lesion, characterized by a yellowish to skin-colored, hairless, verrucous plaque on the head and neck region. In later life, a secondary tumor, either benign or malignant, can develop within nevus sebaceous. Eccrine poroma developing on nevus sebaceous is extremely rare. There are few case reports of eccrine poroma developing within nevus sebaceous. We report a case of a 30-year-old female who presented with a congenital, hairless, verrucous, yellowish lesion on the scalp and an erythematous nodule arising within the yellowish lesion for 8 months. Her clinical presentation and histopathological findings were compatible with nevus sebaceous and eccrine poroma.

  11. Spinal cord injury arising in anaesthesia practice.

    Science.gov (United States)

    Hewson, D W; Bedforth, N M; Hardman, J G

    2018-01-01

    Spinal cord injury arising during anaesthetic practice is a rare event, but one that carries a significant burden in terms of morbidity and mortality. In this article, we will review the pathophysiology of spinal cord injury. We will then discuss injuries relating to patient position, spinal cord hypoperfusion and neuraxial techniques. The most serious causes of spinal cord injury - vertebral canal haematoma, spinal epidural abscess, meningitis and adhesive arachnoiditis - will be discussed in turn. For each condition, we draw attention to practical, evidence-based measures clinicians can undertake to reduce their incidence, or mitigate their severity. Finally, we will discuss transient neurological symptoms. Some cases of spinal cord injury during anaesthesia can be ascribed to anaesthesia itself, arising as a direct consequence of its conduct. The injury to a spinal nerve root by inaccurate and/or incautious needling during spinal anaesthesia is an obvious example. But in many cases, spinal cord injury during anaesthesia is not caused by, related to, or even associated with, the conduct of the anaesthetic. Surgical factors, whether direct (e.g. spinal nerve root damage due to incorrect pedicle screw placement) or indirect (e.g. cord ischaemia following aortic surgery) are responsible for a significant proportion of spinal cord injuries that occur concurrently with the delivery of regional or general anaesthesia. © 2018 The Association of Anaesthetists of Great Britain and Ireland.

  12. Melanotic paraganglioma arising in the temporal horn following Langerhans cell histiocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jeong Hyun [Baylor College of Medicine, Neuroradiology Department, Houston, TX (United States); Ewha Womans University, Radiology Department, School of Medicine, Seoul (Korea); Rivera, Andreana [Baylor College of Medicine, Pathology Department, Houston, TX (United States); Naeini, Ramin M.; Yedururi, Sireesha; Megahead, Hatem [Baylor College of Medicine, Radiology Department, Houston, TX (United States); Bayindir, Petek [Ege Universitesi, Radiology Department, Lojmanlari (Turkey); Fuller, Gregory N. [MD Anderson Cancer Center, Pathology Department, Houston, TX (United States); Suh, Jeong Soo [Ewha Womans University, Radiology Department, School of Medicine, Seoul (Korea); Adesina, Adekunle M. [Baylor College of Medicine, Pathology Department, Houston, TX (United States); Texas Children' s Cancer Center, Houston, TX (United States); Hunter, Jill V. [Texas Children' s Cancer Center, Houston, TX (United States); Baylor College of Medicine, Neuroradiology Department, Houston, TX (United States)

    2008-05-15

    Intracerebral paragangliomas are rare because of the lack of paraganglial cells in the cerebral tissue. We report a rare case of melanotic paraganglioma arising from the temporal horn of the lateral ventricle in a patient with prior Langerhans cell histiocytosis (LCH) treated with chemotherapy and radiation. (orig.)

  13. Periorbital nodular fasciitis arising during pregnancy

    Directory of Open Access Journals (Sweden)

    Brandon N Phillips

    2014-01-01

    Full Text Available Nodular fasciitis (NF is a benign proliferation of fibroblasts and myofibroblasts that rarely occurs in the periorbital region. We report what we believe to be the first case of periorbital NF associated with pregnancy. A case of intravascular fasciitis, a NF variant, has been reported during pregnancy, but it was not located in the periorbital region. A weak presence of estrogen receptors has been reported in NF. This may make it more susceptible to the hormone-related changes during pregnancy and contribute to the development of the lesion by stimulating fibroblasts and smooth muscle cell types. Although rare, NF should be considered in the differential diagnosis of periorbital soft-tissue masses arising during pregnancy.

  14. Cutaneous leiomyosarcoma arising in a smallpox scar

    Science.gov (United States)

    2012-01-01

    Background Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2–3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case presentation A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months’ review the patient was doing well with no evidence of tumour recurrence. Conclusions This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation. PMID:22799750

  15. [Chemical hazards arising from shale gas extraction].

    Science.gov (United States)

    Pakulska, Daria

    2015-01-01

    The development of the shale industry is gaining momentum and hence the analysis of chemical hazards to the environment and health of the local population is extreiely timely and important. Chemical hazards are created during the exploitation of all minerals, but in the case of shale gas production, there is much more uncertainty as regards to the effects of new technologies application. American experience suggests the increasing risk of environmental contamination, mainly groundwater. The greatest, concern is the incomplete knowledge of the composition of fluids used for fracturing shale rock and unpredictability of long-term effects of hydraulic fracturing for the environment and health of residents. High population density in the old continent causes the problem of chemical hazards which is much larger than in the USA. Despite the growing public discontent data on this subject are limited. First of all, there is no epidemiological studies to assess the relationship between risk factors, such as air and water pollution, and health effects in populations living in close proximity to gas wells. The aim of this article is to identify and discuss existing concepts on the sources of environmental contamination, an indication of the environment elements under pressure and potential health risks arising from shale gas extraction.

  16. Chemical hazards arising from shale gas extraction

    Directory of Open Access Journals (Sweden)

    Daria Pakulska

    2015-02-01

    Full Text Available The development of the shale industry is gaining momentum and hence the analysis of chemical hazards to the environment and health of the local population is extremely timely and important. Chemical hazards are created during the exploitation of all minerals, but in the case of shale gas production, there is much more uncertainty as regards to the effects of new technologies application. American experience suggests the increasing risk of environmental contamination, mainly groundwater. The greatest concern is the incomplete knowledge of the composition of fluids used for fracturing shale rock and unpredictability of long-term effects of hydraulic fracturing for the environment and health of residents. High population density in the old continent causes the problem of chemical hazards which is much larger than in the USA. Despite the growing public discontent data on this subject are limited. First of all, there is no epidemiological studies to assess the relationship between risk factors, such as air and water pollution, and health effects in populations living in close proximity to gas wells. The aim of this article is to identify and discuss existing concepts on the sources of environmental contamination, an indication of the environment elements under pressure and potential health risks arising from shale gas extraction. Med Pr 2015;66(1:99–117

  17. Cutaneous leiomyosarcoma arising in a smallpox scar.

    Science.gov (United States)

    Pol, Robert A; Dannenberg, Hilde; Robertus, Jan-Lukas; van Ginkel, Robert J

    2012-07-16

    Cutaneous leiomyosarcoma (CLM) is a very rare smooth muscle tumour that accounts for about 2-3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months' review the patient was doing well with no evidence of tumour recurrence. This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation.

  18. Cutaneous leiomyosarcoma arising in a smallpox scar

    Directory of Open Access Journals (Sweden)

    Pol Robert A

    2012-07-01

    Full Text Available Abstract Background Cutaneous leiomyosarcoma (CLM is a very rare smooth muscle tumour that accounts for about 2–3% of all superficial soft tissue sarcomas. Although the development of various malignancies in scar tissue is well known, we report the first case of a CLM developing in a small pox scar. Case presentation A 66-year-old man presented with a painless, slow-growing lump in a small pox scar on his left shoulder. Histological biopsies showed the lesion to be a primary, well-differentiated cutaneous leiomyosarcoma. A CT scan of the thorax was conducted, which showed no signs of metastases. The complete lesion was then surgically excised, and histopathological examination revealed a radically excised cutaneous type leiomyosarcoma After 13 months’ review the patient was doing well with no evidence of tumour recurrence. Conclusions This is the first report of a CLM arising in a small pox scar. Although the extended time interval between scarring and malignant changes makes it difficult to advise strict follow-up for patients with small pox scars, one should be aware that atypical changes and/or symptoms occurring in a small pox scar could potentially mean malignant transformation.

  19. Wilms tumor arising in extracoelomic paravertebral soft tissues.

    LENUS (Irish Health Repository)

    Mulligan, Linda

    2012-02-01

    Extrarenal Wilms tumor (ERWT) is a well-established entity which most commonly arises within the genitourinary tract, including intracoelomic paranephric soft tissue. Rarely, ERWT arises within teratoma, and it tends to occur predominantly in distinct settings, such as females with spinal defects and males with testicular teratomas. We report a unique ERWT arising within an extracoelomic teratoma of the paraspinal musculature, thereby expanding the range of reported locations for this unusual tumor.

  20. Squamous cell carcinoma arising in mature cystic teratoma of ovary

    Directory of Open Access Journals (Sweden)

    Ranu Patni

    2014-01-01

    Full Text Available Squamous cell carcinoma of the ovary is a rare condition and usually arises in mature cystic teratoma (MCT or dermoid cyst of the ovary. The reported incidence of malignant transformation in MCT is approximately 2%. A case of squamous cell carcinoma arising in a dermoid cyst of the ovary presenting at an early stage is presented here. A 53-year-old postmenopausal lady, presented with the complaint of pain in right lower abdomen since one month and a large complex abdomino-pelvic mass on examination and investigations. Final histopathology was reported as squamous cell carcinoma of left ovary arising from dermoid cyst and a benign dermoid cyst in the right ovary. The patient was assigned to squamous cell carcinoma of the ovary arising in a mature cystic teratoma, surgical stage Ic2. In view of the poor prognosis, adjuvant chemotherapy was started.

  1. Blacks More Prone to Colon Cancers That Arise Between Colonoscopies

    Science.gov (United States)

    ... news/fullstory_165821.html Blacks More Prone to Colon Cancers That Arise Between Colonoscopies: Study Differences in biology ... 22, 2017 MONDAY, May 22, 2017 (HealthDay News) -- Colon cancer guidelines now recommend a colonoscopy every 10 years, ...

  2. Number theory arising from finite fields analytic and probabilistic theory

    CERN Document Server

    Knopfmacher, John

    2001-01-01

    ""Number Theory Arising from Finite Fields: Analytic and Probabilistic Theory"" offers a discussion of the advances and developments in the field of number theory arising from finite fields. It emphasizes mean-value theorems of multiplicative functions, the theory of additive formulations, and the normal distribution of values from additive functions. The work explores calculations from classical stages to emerging discoveries in alternative abstract prime number theorems.

  3. Radiological protection issues arising during and after the Fukushima nuclear reactor accident.

    Science.gov (United States)

    González, Abel J; Akashi, Makoto; Boice, John D; Chino, Masamichi; Homma, Toshimitsu; Ishigure, Nobuhito; Kai, Michiaki; Kusumi, Shizuyo; Lee, Jai-Ki; Menzel, Hans-Georg; Niwa, Ohtsura; Sakai, Kazuo; Weiss, Wolfgang; Yamashita, Shunichi; Yonekura, Yoshiharu

    2013-09-01

    Following the Fukushima accident, the International Commission on Radiological Protection (ICRP) convened a task group to compile lessons learned from the nuclear reactor accident at the Fukushima Daiichi nuclear power plant in Japan, with respect to the ICRP system of radiological protection. In this memorandum the members of the task group express their personal views on issues arising during and after the accident, without explicit endorsement of or approval by the ICRP. While the affected people were largely protected against radiation exposure and no one incurred a lethal dose of radiation (or a dose sufficiently large to cause radiation sickness), many radiological protection questions were raised. The following issues were identified: inferring radiation risks (and the misunderstanding of nominal risk coefficients); attributing radiation effects from low dose exposures; quantifying radiation exposure; assessing the importance of internal exposures; managing emergency crises; protecting rescuers and volunteers; responding with medical aid; justifying necessary but disruptive protective actions; transiting from an emergency to an existing situation; rehabilitating evacuated areas; restricting individual doses of members of the public; caring for infants and children; categorising public exposures due to an accident; considering pregnant women and their foetuses and embryos; monitoring public protection; dealing with 'contamination' of territories, rubble and residues and consumer products; recognising the importance of psychological consequences; and fostering the sharing of information. Relevant ICRP Recommendations were scrutinised, lessons were collected and suggestions were compiled. It was concluded that the radiological protection community has an ethical duty to learn from the lessons of Fukushima and resolve any identified challenges. Before another large accident occurs, it should be ensured that inter alia: radiation risk coefficients of potential

  4. Four Different Tumors Arising in a Nevus Sebaceous

    Directory of Open Access Journals (Sweden)

    Takeshi Namiki

    2016-04-01

    Full Text Available Nevus sebaceous is known by its association with one or more secondary tumors, but more than three multiple tumors arising from a nevus sebaceous is extremely rare. A 67-year-old female presented with a light brown plaque on the back of her head that contained a dome-shaped black node and an erosive lesion. Histopathological examination showed atypical basaloid cells in the black node. At the periphery of that node, structures resembling follicular germs extruded from interlacing cords in the upper portion and tumor nests with sebocytes were in the lower portion. In the erosive lesion, papillated structures with an apocrine epithelium were observed. In the light brown plaque, enlargement of sebaceous lobules was noted. From those histopathological features, a diagnosis of syringocystadenoma papilliferum, sebaceoma, trichoblastoma and basal cell carcinoma arising from a nevus sebaceous was made. We discuss the rarity of multiple tumors arising from a nevus sebaceous.

  5. Anomalous Posterior Intercostal Arterial Trunk Arising From the Abdominal Aorta

    Energy Technology Data Exchange (ETDEWEB)

    Jie, Bing, E-mail: jbshh@163.com; Yu, Dong, E-mail: yudong-mail@126.com; Jiang, Sen, E-mail: jasfly77@vip.163.com [Tongji University School of Medicine, Department of Radiology, Shanghai Pulmonary Hospital (China)

    2016-04-15

    A common trunk of the ipsilateral posterior intercostal artery (PIA) arising from the thoracic aorta is usually an anatomical variation. However, a common trunk of bilateral posterior intercostal arterial trunk (PIAT) arising from the abdominal aorta is rare. It is important to recognize this anatomical variation of PIA when performing interventional radiological procedures. We present a rare case of an anomalous PIAT that originated from the abdominal aorta in a patient with hemoptysis caused by tuberculosis sequelae. Bilateral 4th to 11th PIAs arose from a common trunk and the trunk arising from the posterior aspect of the abdominal aorta at the level of T12/L1 intervertebral space. The pathological right 4th and 5th PIAs and bronchial arteries were embolized. Hemoptysis has been controlled for 3 months.

  6. Papillary Carcinoma Arising from the Pyramidal Lobe of the Thyroid

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Gi; Lee, Sarah; Kim, Eun Kyung; Moon, Hee Jung; Kwak, Jin Young [Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2012-03-15

    The authors present a rare case of papillary carcinoma arising from the pyramidal lobe of the thyroid in a 54-year-old woman, who presented with a right submental palpable mass. An ultrasound evaluation depicted a 3 cm mixed echoic mass from the thyroid cartilage level without a focal lesion in the thyroid gland. Surgical specimens obtained during bilateral thyroidectomy confirmed papillary carcinoma of the pyramidal lobe. To the authors' knowledge, this is the first case report to describe papillary carcinoma arising from the pyramidal lobe of the thyroid gland

  7. Osteosarcoma Arising in a S,olitary Osteochondroma

    African Journals Online (AJOL)

    1971-07-24

    Jul 24, 1971 ... In his patients osteo- sarcoma arose from an osteochondroma at the distal end of the femur. The complete files of the Mayo Clinic contain only 3 such cases.' Anderson et al.' reported a case of a sarcoma arising from an osteochondroma of the upper tibia. There was some doubt a to the precise histology of.

  8. Primary Malignant Amelanotic Melanoma Arising From a Vitiligo ...

    African Journals Online (AJOL)

    Skin cancer is rare in people of African origin while vitiligo occurs worldwide. The occurrence of primary malignant melanoma and vitiligo together is very rare. We present a rare case of primary malignant amelanotic melanoma arising from a depigmented patch of a patient with vitiligo. It was completely excised and followed ...

  9. Solitary fibrous tumor arising in an intrathoracic goiter

    DEFF Research Database (Denmark)

    Larsen, Stine Rosenkilde; Godballe, Christian; Krogdahl, Annelise

    2010-01-01

    BACKGROUND: Solitary fibrous tumor (SFT) is a rare spindle cell tumor most often found in the mediastinal pleura. Nineteen cases of SFT arising in the thyroid gland have been reported. We report a case of SFT of the thyroid gland with immunohistochemical and cytogenetic investigation. SUMMARY: A 58...

  10. Infiltrative Oncocytoma arising from minor salivary glands of palate ...

    African Journals Online (AJOL)

    Oncocytoma of salivary gland origin is an uncommon tumor found mainly in the parotid gland. On rare occasions, oncocytoma arise in the intra-oral minor salivary glands; having a greater tendency for locally aggressive behavior and infiltrating the adjacent tissues due to incomplete encapsulation. The current case is of ...

  11. Lower Limb Injuries Arising From Motorcycle Crashes | Kortor ...

    African Journals Online (AJOL)

    Methods: All the patients with lower limb injuries arising from motorcycle accidents who presented in our hospital between 1st October 2006 and 30th September 2007 were reviewed. History was obtained and detailed examination was done after resuscitation to determine the site, nature and the characteristics of injuries.

  12. Transcultural Knowledge and Skills Transfer: Issues Arising from Evaluation Processes

    Science.gov (United States)

    Green, Anita J.; Holloway, David G.

    2007-01-01

    The transfer of knowledge, policy and practice between nations increasingly involves knowledge of the theory and practice of evaluation. This article examines issues arising from the transcultural evaluation of a drug and alcohol misuse knowledge and skills transfer programme for nurses, nurse teachers and medical staff in the narcology service in…

  13. Marjolin's ulcer arising from cutaneous lichen planus | Olawoye ...

    African Journals Online (AJOL)

    The association between cutaneous lichen planus and Squamous cell carcinoma has been controversial. The rarity of documented cases, has led some to suggest that it may represent a chance association. Whilst there have been many reports of Marjolin's ulcer arising from oral lichen planus, reports of Squamous cell ...

  14. A rare case of Cystic artery arising from Gastroduodenal artery ...

    African Journals Online (AJOL)

    An uncommon anatomical variation in the origin and course of cystic artery was found during human cadaveric dissection in our laboratory. A blood vessel was seen arising from the gastroduodenal artery about 1 cm distal to its origin from the common hepatic artery. The vessel when traced towards its termination was found ...

  15. Knowledge Protection and Input Complexity Arising from Open Innovation

    DEFF Research Database (Denmark)

    Peeters, Thijs; Sofka, Wolfgang

    Controlling unique knowledge is of increasing importance to firms. Therefore, firms use knowledge protection mechanisms to prevent competitors from imitating their knowledge. We study the effects of the complexity of knowledge inputs that arises from open innovation on the importance of two widely...

  16. Atypical compound nevus arising in mature cystic ovarian teratoma.

    Science.gov (United States)

    McHugh, Jonathan B; Fullen, Douglas R

    2006-04-01

    Mature cystic ovarian teratoma (MCOT) is the most common primary ovarian tumor. Rarely, MCOT may undergo malignant transformation. Melanoma arising primarily in MCOT is a rare event. Melanocytic nevi have also rarely been reported in MCOT. A 28 year-old female presented with a palpable, 4.6 cm, right pelvic mass on physical examination. Histologically, the cystic neoplasm demonstrated epidermis with numerous pilosebaceous units and respiratory-type epithelium (endoderm) surrounded by adipose tissue and cartilage (mesoderm). A 2.0 x 1.0 cm pigmented area corresponded to a nevus with architectural and cytologic features of the so-called "dysplastic nevus," including variable-sized nests of nevomelanocytes irregularly distributed on distorted rete ridges, bridging of nests between rete ridges, fibroplasia around rete ridges, and junctional shouldering beyond the dermal nevus. The nevomelanocytes demonstrated moderate cytologic atypia. Diagnostic criteria of melanoma were not identified. Herein, we report, to the best of our knowledge, the first case of an atypical ("dysplastic") nevus, arising in a MCOT. No features of melanoma were present and the patient is disease-free at one-year follow-up. Rarely, melanocytic nevi and melanomas arise from the ectodermal component of MCOTs. Moreover, melanomas may arise de novo or in association with a nevus. Distinction between a melanocytic nevus, as in our case, and a primary melanoma is critical for determining the patient's prognosis and need for additional therapy. As primary ovarian melanomas, like their skin counterpart, may arise from a precursor lesion, removal of a melanocytic nevus, such as this atypical nevus, could theoretically prevent melanoma transformation.

  17. Partial difference equations arising from the Cauchy-Riemann equations

    Directory of Open Access Journals (Sweden)

    S. Haruki

    2006-06-01

    Full Text Available We consider some functional equations arising from the Cauchy-Riemann equations, and certain related functional equations. First we propose a new functional equation (E.1 below, over a $2$-divisible Abelian group, which is a discrete version of the Cauchy-Riemann equations, and give the general solutions of (E.1. Next we study a functional equation which is equivalent to (E.1. Further we propose and solve partial difference-differential functional equations and nonsymmetric partial difference equations which are also arising from the Cauchy--Riemann equations. [ f(x+t,y- f(x-t,y = - i [f(x,y+t- f(x,y-t].    (E.1

  18. Angiosarcoma Arising in an Ovarian Fibroma: A Case Report

    Directory of Open Access Journals (Sweden)

    Eduardo Cambruzzi

    2010-01-01

    Full Text Available Primary ovarian angiosarcoma is a very rare gynaecological sarcoma, with poor prognosis. These tumors are though to arise from carcinosarcomas, teratomas, or the ovarian vasculature and occur at any age. There are only a few cases reported in the international literature, most commonly associated to surface epithelial-stromal or germ cell tumours. Herein, the authors report the clinicopathologic features of an angiosarcoma arising in an ovarian fibroma. A 65-year-old patient was admitted with a palpable mass in the hypogastrium. Grossly, the removed ovary was completely replaced by a solid tumor mass. On histological analysis, the lesion revealed the typical histological features of angiosarcoma with sinusoidal patterns and anaplastic cells, admixed with spindle-shaped cells arranged in fascicles or in a storiform pattern, compatible with a fibroma. The vascular component was strongly immunopositive for CD31 and CD34. The patient was submitted to chemotherapy, and she was alive for two months after surgical proceedings.

  19. Autopsy case of squamous cell carcinoma arising from pancreas

    Energy Technology Data Exchange (ETDEWEB)

    Saijo, Noboru; Maeda, Ken (Rumoi City General Hospital, Hokkaido (Japan)); Kita, Shinichiro; Ishigaki, Seishi; Sone, Hisao

    1983-02-01

    An 80-year-old male patient was admitted complaining of abdominal mass. The mass showed a large doughnut shape in scintigraphy with /sup 67/Ga and a honeycomb appearance in abdominal echography. Continuous fever, ascitis and anuria caused the patient to be inoperable and death occurred. Postmortem examination revealed a rare case of squamous cell carcinoma arising from pancreas. Diagnosis for the squamous cell carcinoma of the pancreas was discussed in this paper.

  20. Mucosa-associated lymphoid tissue lymphoma arising from the kidney

    Science.gov (United States)

    Niwa, Naoya; Tanaka, Nobuyuki; Horinaga, Minoru; Hongo, Hiroshi; Ito, Yujiro; Watanabe, Takuro; Masuda, Takeshi

    2014-01-01

    Primary renal lymphoma is rare, and most are intermediate- and high-grade lymphomas of B-cell lineage, such as diffuse large B-cell or Burkitt lymphoma. We report a case of low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) arising from the kidney. Only a few cases of primary renal MALT lymphoma have been published. PMID:24554980

  1. Primary Osteosarcoma of the Breast Arising in an Intraductal Papilloma

    OpenAIRE

    Khalefa Ali Alghofaily; Musab Hamoud Almushayqih; Muhannad Faleh Alanazi; Abdullah Abdulrahman Bin Salamah; Halldor Benediktsson

    2017-01-01

    Introduction. Primary osteosarcoma of the breast is extremely rare, and an osteosarcoma arising from an intraductal papilloma is exceptional. Case Presentation. A 72-year-old Saudi Arabian woman presented with a solid, bone-containing breast mass that was diagnosed as primary osteosarcoma of the breast on biopsy. She had a history of untreated intraductal papilloma. Treatment was completed with a modified mastectomy after excluding extramammary metastases. However, she subsequently developed ...

  2. Isolated Sessile Chondrosarcoma Arising in Osteochondroma: A Case Report

    OpenAIRE

    Kalem, Mahmut; Sevimli, Reşit; Ünlü, Adem; Sağlık, Yener

    2014-01-01

    Osteochondroma of the most common benign bone tumors are from youth, mostly in the metaphyses of long bones is determined as a single mass. Causing severe pain and surgical treatment is recommended due to the risk of development chondrosarcoma. In this paper, an osteochondroma arising from the proximal humerus osteochondroma developed in the case of chondrosarcoma diagnosis, treatment and follow-up of patients was presented.

  3. Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management.

    Science.gov (United States)

    Junqueira, A L; Wanat, K A; Farah, R S

    2017-08-01

    Tattooing, which involves the placement of ink into the skin, is an ancient decorative technique that has remained popular in modern society. Tattoos have long been known to cause cutaneous reactions, which include the emergence of neoplasms such as keratoacanthoma (KA) and squamous cell carcinoma (SCC) in tattooed areas of the skin. We review the clinical presentations, histology and treatment options for squamous neoplasms, primarily KA and SCC, arising in tattoos. © 2017 British Association of Dermatologists.

  4. Mycobacterium fortuitum infection arising in a new tattoo

    OpenAIRE

    Philips, Rebecca C.; Hunter-Ellul, Lindsey A; Martin, Julie E; Wilkerson, Michael G.

    2014-01-01

    We report an uncommon case of a cutaneous infection with Mycobacterium fortuitum arising in a new tattoo. A 29-year-old man presented with a several month history of a non-pruritic papular eruption within a tattoo; the papules developed 1-to-2 weeks after the tattoo procedure. He denied similar symptoms with previous tattoos. He had been treated unsuccessfully with cephalexin. Histopathologic examination revealed perifollicular chronic and granulomatous inflammation, consistent with chronic f...

  5. EPR-dosimetry of ionizing radiation

    Science.gov (United States)

    Popova, Mariia; Vakhnin, Dmitrii; Tyshchenko, Igor

    2017-09-01

    This article discusses the problems that arise during the radiation sterilization of medical products. It is propose the solution based on alanine EPR-dosimetry. The parameters of spectrometer and methods of absorbed dose calculation are given. In addition, the problems that arise during heavy particles irradiation are investigated.

  6. Radiation incidents in dentistry

    Energy Technology Data Exchange (ETDEWEB)

    Lovelock, D.J. [Dental Hospital and School, Newcastle upon Tyne (United Kingdom). Dept. of Radiology

    1996-12-31

    Most dental practitioners act as their own radiographer and radiologist, unlike their medical colleagues. Virtually all dental surgeons have a dental X-ray machine for intraoral radiography available to them and 40% of dental practices have equipment for dental panoramic tomography. Because of the low energy of X-ray equipment used in dentistry, radiation incidents tend to be less serious than those associated with other aspects of patient care. Details of 47 known incidents are given. The advent of the 1985 and 1988 Ionising Radiation Regulations has made dental surgeons more aware of the hazards of radiation. These regulations, and general health and safety legislation, have led to a few dental surgeons facing legal action. Because of the publicity associated with these court cases, it is expected that there will be a decrease in radiation incidents arising from the practice of dentistry. (author).

  7. Primary Osteosarcoma of the Breast Arising in an Intraductal Papilloma

    Directory of Open Access Journals (Sweden)

    Khalefa Ali Alghofaily

    2017-01-01

    Full Text Available Introduction. Primary osteosarcoma of the breast is extremely rare, and an osteosarcoma arising from an intraductal papilloma is exceptional. Case Presentation. A 72-year-old Saudi Arabian woman presented with a solid, bone-containing breast mass that was diagnosed as primary osteosarcoma of the breast on biopsy. She had a history of untreated intraductal papilloma. Treatment was completed with a modified mastectomy after excluding extramammary metastases. However, she subsequently developed multiple recurrent lesions at the same site. Conclusion. Primary osteogenic sarcomas of the breast are very rare. Although the main treatment is resection the optimal management remains uncertain and prognosis is poor.

  8. Dealing with uncertainty arising out of probabilistic risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, K.A.; Kastenberg, W.E.; Nelson, P.F.

    1984-03-01

    In addressing the area of safety goal implementation, the question of uncertainty arises. This report suggests that the Nuclear Regulatory Commission (NRC) should examine how other regulatory organizations have addressed the issue. Several examples are given from the chemical industry, and comparisons are made to nuclear power risks. Recommendations are made as to various considerations that the NRC should require in probabilistic risk assessments in order to properly treat uncertainties in the implementation of the safety goal policy. 40 references, 7 figures, 5 tables.

  9. Facial Cellulitis Arising from Dens Evaginatus: A Case Report

    Directory of Open Access Journals (Sweden)

    Chun-Ming Chen

    2005-07-01

    Full Text Available Dens evaginatus is a developmental anomaly that produces a tubercle on the occlusal surface of a tooth. It is found most frequently in the mandibular premolars. The occlusal tubercle easily causes occlusal interferences. Attrition or fracture of the tubercle can lead to pulpitis, pulp necrosis, periapical pathosis, and periapical infection. This case report illustrates the treatment of facial cellulitis arising from dens evaginatus with open apex. Calcium hydroxide was used for the apexification procedure. One year after canal obturation, radiography revealed no apical pathosis and the apical seal was evident.

  10. Foregut duplication cyst arising in the floor of mouth.

    Science.gov (United States)

    Kong, Kelvin; Walker, Paul; Cassey, John; O'Callaghan, Stephen

    2004-06-01

    Enteric duplications are uncommon. A rare foregut duplication cyst arising in the floor of mouth is reported. Diagnosis of cystic lesion within the oral cavity was made in utero. Enteric duplications have not yet been attributed to a single embryogenesis but are likely to represent an error in migration of normal cells that rest in an abnormal position. Immediately following delivery of the neonate via an ex-utero intrapartum treatment (EXIT) procedure, the cyst was marsupialised but required definitive surgical excision at 5 weeks of age.

  11. Some problems arising in analysis of large-scale animal irradiation are described experiments

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.; Staffeldt, E.; Tyler, S.A.

    1978-01-01

    Problems that occur in experiments designed particularly to study the effects of irradiation are described. One of the purposes of such experiments is to provide data that allow an informed judgment on estimates of the risks for man after exposue to radiation. It is no trivial matter to establish whether exposure to agents, such as radiation, increases the probability of a tumor arising de novo or whether the effect is an advancement of the time of appearance of naturally occurring tumors. In many murine tumors, the problem of establishing which of these two possibilities is the case is increased by the high natural incidence. In order to interpret the data from carcinogenesis experiments, a knowledge of the natural history of the tumor of interest is necessary. In this paper we present data that help to elucidate the biology of lung tumors in hybrid B6CF/sub 1//An1 mice. The rising incidence of many tumors late in life raises the question of whether a common systemic factor is involved. In experiments with female mice, relatively low doses of radiation may sterilize the ovary with subsequent hormonal imbalances that in turn may influence the appearance of tumors in a number of hormone-influenced tissues. We have found that radiation may increase not only the age-specific rates of tumors but also the probability of the number of different tumor types. The possibility of a lack of independence of the occurrences of different tumors complicates the data analysis. To answer some of the questions we have raised, it would be of considerable help to have data on the prevalence of tumors; however, such data usually involve serial killing which is costly. We have examined the possibility of obtaining prevalence data for lung tumors by the determination of the incidence of lung tumors in mice dying from causes other than lung tumors.

  12. Extradural Myxopapillary Ependymoma arising in the lower lumbar ...

    African Journals Online (AJOL)

    Spinal extradural ependymoma is a rare tumor; we report an unusual case of extradural lumbar ependymoma and review the relevant literature. A 58 years old male presented with the history of low back pain of 4 months duration radiating to both the lower limbs (left more than the right), difficulty in gripping footwear and ...

  13. Basal Cell Carcinoma Arising in a Breast Augmentation Scar.

    Science.gov (United States)

    Edwards, Lisa R; Cresce, Nicole D; Russell, Mark A

    2017-04-01

    We report a case of a 46-year-old female who presented with a persistent lesion on the inferior right breast. The lesion was located within the scar from a breast augmentation procedure 12 years ago. The lesion had been treated as several conditions with no improvement. Biopsy revealed a superficial and nodular basal cell carcinoma, and the lesion was successfully removed with Mohs micrographic surgery. Basal cell carcinoma arising in a surgical scar is exceedingly rare with only 13 reported cases to date. This is the first reported case of basal cell carcinoma arising in a breast augmentation scar. We emphasize the importance of biopsy for suspicious lesions or those refractory to treatment, particularly those lesions that form within a scar. Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

  14. Poorly Differentiated Squamous Cell Carcinoma Arising in Tattooed Skin

    Directory of Open Access Journals (Sweden)

    Deba P. Sarma

    2010-01-01

    Full Text Available Introduction. Tattoos have increasingly become accepted by mainstream Western society. As a result, the incidence of tattoo-associated dermatoses is on the rise. The presence of a poorly differentiated squamous cell carcinoma in an old tattooed skin is of interest as it has not been previously documented. Case Presentation. A 79-year-old white homeless man of European descent presented to the dermatology clinic with a painless raised nodule on his left forearm arising in a tattooed area. A biopsy of the lesion revealed a poorly differentiated squamous cell carcinoma infiltrating into a tattoo. The lesion was completely excised and the patient remains disease-free one year later. Conclusion. All previous reports of squamous cell carcinomas arising in tattoos have been well-differentiated low-grade type or keratoacanthoma-type and are considered to be coincidental rather than related to any carcinogenic effect of the tattoo pigments. Tattoo-associated poorly differentiated invasive carcinoma appears to be extremely rare.

  15. Trichoepithelioma Arising in an Ovarian Mature Cystic Teratoma

    Directory of Open Access Journals (Sweden)

    Takashi Suzuki

    2016-01-01

    Full Text Available Here, we report an extremely rare case of trichoepithelioma (TE—a benign epithelial tumor originating from the outer root sheath of a hair follicle—arising in an ovarian mature cystic teratoma (MCT with fluorodeoxyglucose-positron emission tomography (FDG-PET findings. A 48-year-old Japanese woman presented to our hospital for her annual follow-up of adenomyosis. Ultrasonography and magnetic resonance imaging revealed a left ovarian tumor with irregular-shaped septum, which was suspicious of malignancy. However, tumor marker levels were within normal range. On FDG-PET, the maximum standardized uptake value (SUVmax of the tumor was 2.9. Laparotomy with left salpingooophorectomy was performed. Pathologic examination revealed the probability of TE, rather than basal cell carcinoma (BCC, arising in an ovarian MCT. After five years of follow-up, the patient had no sign of recurrence. The FDG-PET SUVmax was low in TE, as with other benign tumor. However, future investigation is needed to evaluate the findings of FDG-PET imaging in TE cases.

  16. Oscillations in biochemical reaction networks arising from pairs of subnetworks.

    Science.gov (United States)

    Mincheva, Maya

    2011-10-01

    Biochemical reaction models show a variety of dynamical behaviors, such as stable steady states, multistability, and oscillations. Biochemical reaction networks with generalized mass action kinetics are represented as directed bipartite graphs with nodes for species and reactions. The bipartite graph of a biochemical reaction network usually contains at least one cycle, i.e., a sequence of nodes and directed edges which starts and ends at the same species node. Cycles can be positive or negative, and it has been shown that oscillations can arise as a result of either a positive cycle or a negative cycle. In earlier work it was shown that oscillations associated with a positive cycle can arise from subnetworks with an odd number of positive cycles. In this article we formulate a similar graph-theoretic condition, which generalizes the negative cycle condition for oscillations. This new graph-theoretic condition for oscillations involves pairs of subnetworks with an even number of positive cycles. An example of a calcium reaction network with generalized mass action kinetics is discussed in detail.

  17. High-Grade Leiomyosarcoma Arising in a Previously Replanted Limb

    Directory of Open Access Journals (Sweden)

    Tiffany J. Pan

    2015-01-01

    Full Text Available Sarcoma development has been associated with genetics, irradiation, viral infections, and immunodeficiency. Reports of sarcomas arising in the setting of prior trauma, as in burn scars or fracture sites, are rare. We report a case of a leiomyosarcoma arising in an arm that had previously been replanted at the level of the elbow joint following traumatic amputation when the patient was eight years old. He presented twenty-four years later with a 10.8 cm mass in the replanted arm located on the volar forearm. The tumor was completely resected and pathology examination showed a high-grade, subfascial spindle cell sarcoma diagnosed as a grade 3 leiomyosarcoma with stage pT2bNxMx. The patient underwent treatment with brachytherapy, reconstruction with a free flap, and subsequently chemotherapy. To the best of our knowledge, this is the first case report of leiomyosarcoma developing in a replanted extremity. Development of leiomyosarcoma in this case could be related to revascularization, scar formation, or chronic injury after replantation. The patient remains healthy without signs of recurrence at three-year follow-up.

  18. An Aberrant Artery Arising From Common Hepatic Artery

    Directory of Open Access Journals (Sweden)

    Surekha D. Jadhav

    2015-01-01

    Full Text Available Common hepatic artery is the branch of celiac trunk which is chief artery of the foregut. Branches of celiac trunk supply the gastrointestinal tract and its associated glands which are derived from foregut. Anatomy and variations of hepatic arterial system have become increasingly important due to increasing number of laparoscopic procedures, oncologic surgical interventions, and organ transplant cases. This case report describes a rare anatomical variation of an aberrant artery arising from common hepatic artery before the origin of gastroduodenal artery and proper hepatic artery.The aberrant artery traversed inferiorly and behind the body of the pancreas which divided into a right and left branches. The right branch ran behind the neck of the pancreas and it ended after giving few branches to head and body of pancreas. However, the left branch gave off branches to the proximal part of the jejunum. The presence of a branch arising directly from the common hepatic artery supplying the pancreas and jejunum is uncommon. Knowledge of such a rare variation is important not only for surgeons but also interventional radiologists and those studying anatomy

  19. Multiple Ectopic Hepatocellular Carcinomas Arising in the Abdominal Cavity

    Directory of Open Access Journals (Sweden)

    Toru Miyake

    2012-09-01

    Full Text Available Ectopic hepatocellular carcinoma (HCC is a very rare clinical entity that is defined as HCC arising from extrahepatic liver tissue. This report presents a case of ectopic multiple HCC arising in the abdominal cavity. A 42-year-old otherwise healthy male presented with liver dysfunction at a general health checkup. Both HCV antibody and hepatitis B surface antigen were negative. Laboratory examination showed elevations in serum alpha-fetoprotein and PIVKA-II. Ultrasonography and computed tomography revealed multiple nodular lesions in the abdominal cavity with ascites without a possible primary tumor. Exploratory laparoscopy was performed, which revealed bloody ascites and multiple brown nodular tumors measuring approximately 10 mm in size that were disseminated on the perineum and mesentery. A postoperative PET-CT scan was performed but it did not reveal any evidence of a tumor in the liver. The tumors resected from the peritoneum were diagnosed as HCC. The present case of HCC was thought to have possibly developed from ectopic liver on the peritoneum or mesentery.

  20. Radiation Therapy

    Science.gov (United States)

    ... Be extra careful not to spend time with children or pregnant women. Internal Radiation Therapy Makes You Give Off Radiation With systemic radiation, your body fluids ( urine , sweat, and saliva ) will give off radiation for a while. With ...

  1. Radiation enteritis

    Science.gov (United States)

    Radiation enteropathy; Radiation-induced small bowel injury; Post-radiation enteritis ... Radiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells. The therapy ...

  2. Lymphatic vessels arise from specialized angioblasts within a venous niche.

    Science.gov (United States)

    Nicenboim, J; Malkinson, G; Lupo, T; Asaf, L; Sela, Y; Mayseless, O; Gibbs-Bar, L; Senderovich, N; Hashimshony, T; Shin, M; Jerafi-Vider, A; Avraham-Davidi, I; Krupalnik, V; Hofi, R; Almog, G; Astin, J W; Golani, O; Ben-Dor, S; Crosier, P S; Herzog, W; Lawson, N D; Hanna, J H; Yanai, I; Yaniv, K

    2015-06-04

    How cells acquire their fate is a fundamental question in developmental and regenerative biology. Multipotent progenitors undergo cell-fate restriction in response to cues from the microenvironment, the nature of which is poorly understood. In the case of the lymphatic system, venous cells from the cardinal vein are thought to generate lymphatic vessels through trans-differentiation. Here we show that in zebrafish, lymphatic progenitors arise from a previously uncharacterized niche of specialized angioblasts within the cardinal vein, which also generates arterial and venous fates. We further identify Wnt5b as a novel lymphatic inductive signal and show that it also promotes the ‘angioblast-to-lymphatic’ transition in human embryonic stem cells, suggesting that this process is evolutionarily conserved. Our results uncover a novel mechanism of lymphatic specification, and provide the first characterization of the lymphatic inductive niche. More broadly, our findings highlight the cardinal vein as a heterogeneous structure, analogous to the haematopoietic niche in the aortic floor.

  3. Oral squamous cell carcinoma arising around osseointegrated dental implants.

    Science.gov (United States)

    Javed, Fawad; Al-Askar, Mansour; Qayyum, Faisal; Wang, Hom-Lay; Al-Hezaimi, Khalid

    2012-08-01

    This literature review investigates the occurrence of oral squamous cell carcinoma (OSCC) around osseointegrated dental implants (DI). Databases were searched from 1989 up to and including November 2011. The eligibility criteria were as follows: (1) original studies, (2) clinical studies and case reports, (3) reference lists of the relevant original and review articles, (4) intervention: occurrence of OSSC around osseointegrated DI, and (5) articles published only in English language. Fourteen studies were included. In nine studies, the dental implant patients with diagnosed OSCC had previously been exposed to cancer. In five studies, the patients presented with a history of habitual tobacco smoking and alcohol consumption. OSCC is more likely to arise around osseointegrated DI in patients with a previous history of cancer. However, the role of other factors including tobacco and alcohol usage cannot be disregarded.

  4. Clear Cell Adenocarcinoma Arising from Abdominal Wall Endometriosis

    Directory of Open Access Journals (Sweden)

    Thouraya Achach

    2008-01-01

    Full Text Available Endometriosis is a frequent benign disorder. Malignancy arising in extraovarian endometriosis is a rare event. A 49-year-old woman is presented with a large painful abdominal wall mass. She underwent a myomectomy, 20 years before, for uterus leiomyoma. Computed tomography suggested that this was a desmoid tumor and she underwent surgery. Histological examination showed a clear cell adenocarcinoma associated with endometriosis foci. Pelvic ultrasound, computed tomography, and endometrial curettage did not show any malignancy or endometriosis in the uterus and ovaries. Adjuvant chemotherapy was recommended, but the patient was lost to follow up. Six months later, she returned with a recurrence of the abdominal wall mass. She was given chemotherapy and then she was reoperated.

  5. [Gender stereotypes arising in a state of gender awareness].

    Science.gov (United States)

    Ito, Y

    2001-12-01

    This study examined the structure of gender stereotypes which might arise in the state of gender awareness that was triggered by social situations where people perceived their gender differences strongly. Out of 1,500 residents in Tokyo aged between 20-60, 342 females and 313 males were randomly chosen and answered the questions about gender consciousness in the state of gender awareness. A factor analysis revealed that "maternity" and "trustworthiness" were the dominant dimensions of gender stereotypes in the state of gender awareness, and that trustworthiness particularly formed the basis of gender stereotypes. Generation differences in gender stereotypes were also revealed between women in their 40 s and 50 s, and between men in their 30 s and 40 s. Generally, power for men and nurture for women were more likely to be perceived in a state of gender awareness.

  6. Cesium vapor thermionic converter anomalies arising from negative ion emission

    Science.gov (United States)

    Rasor, Ned S.

    2016-08-01

    Compelling experimental evidence is given that a longstanding limit encountered on cesium vapor thermionic energy converter performance improvement and other anomalies arise from thermionic emission of cesium negative ions. It is shown that the energy that characterizes thermionic emission of cesium negative ions is 1.38 eV and, understandably, is not the electron affinity 0.47 eV determined for the photodetachment threshold of the cesium negative ion. The experimental evidence includes measurements of collector work functions and volt-ampere characteristics in quasi-vacuum cesium vapor thermionic diodes, along with reinterpretation of the classic Taylor-Langmuir S-curve data on electron emission in cesium vapor. The quantitative effects of negative ion emission on performance in the ignited, unignited, and quasi-vacuum modes of cesium vapor thermionic converter operation are estimated.

  7. Optimal control of switched systems arising in fermentation processes

    CERN Document Server

    Liu, Chongyang

    2014-01-01

    The book presents, in a systematic manner, the optimal controls under different mathematical models in fermentation processes. Variant mathematical models – i.e., those for multistage systems; switched autonomous systems; time-dependent and state-dependent switched systems; multistage time-delay systems and switched time-delay systems – for fed-batch fermentation processes are proposed and the theories and algorithms of their optimal control problems are studied and discussed. By putting forward novel methods and innovative tools, the book provides a state-of-the-art and comprehensive systematic treatment of optimal control problems arising in fermentation processes. It not only develops nonlinear dynamical system, optimal control theory and optimization algorithms, but can also help to increase productivity and provide valuable reference material on commercial fermentation processes.

  8. Dioxins: diagnostic and prognostic challenges arising from complex mechanisms

    DEFF Research Database (Denmark)

    Rysavy, Noel M.; Maaetoft-Udsen, Kristina; Turner, Helen

    2013-01-01

    Dioxins are ubiquitous environmental challenges to humans, with a pervasiveness that arises from 200?years of rapid industrialization and mechanization of Western societies and which is now extending into the developing world. In spite of their penetrance of the human biota, these compounds...... are poorly understood in terms of their true physiological potential for harm, and the mechanisms by which they impact cellular and organ level function are only recently becoming clear. Emerging awareness that chronic exposures to toxins may have generational and subtle effects on the outcomes of diseases...... exogenous ligands, as well as the mechanisms by which these ligands impact acute and chronic cellular processes, are discussed. We develop the idea that the diagnosis of dioxin exposure, the subtleties of the cellular effects of the compounds and prognosis of the long-term effects of exposure are problems...

  9. Irregular activity arises as a natural consequence of synaptic inhibition

    Energy Technology Data Exchange (ETDEWEB)

    Terman, D., E-mail: terman@math.ohio-state.edu [Department of Mathematics, The Ohio State University, Columbus, Ohio 43210 (United States); Rubin, J. E., E-mail: jonrubin@pitt.edu [Department of Mathematics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 (United States); Diekman, C. O., E-mail: diekman@njit.edu [Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102 (United States)

    2013-12-15

    Irregular neuronal activity is observed in a variety of brain regions and states. This work illustrates a novel mechanism by which irregular activity naturally emerges in two-cell neuronal networks featuring coupling by synaptic inhibition. We introduce a one-dimensional map that captures the irregular activity occurring in our simulations of conductance-based differential equations and mathematically analyze the instability of fixed points corresponding to synchronous and antiphase spiking for this map. We find that the irregular solutions that arise exhibit expansion, contraction, and folding in phase space, as expected in chaotic dynamics. Our analysis shows that these features are produced from the interplay of synaptic inhibition with sodium, potassium, and leak currents in a conductance-based framework and provides precise conditions on parameters that ensure that irregular activity will occur. In particular, the temporal details of spiking dynamics must be present for a model to exhibit this irregularity mechanism and must be considered analytically to capture these effects.

  10. Estimation of measurement uncertainty arising from manual sampling of fuels.

    Science.gov (United States)

    Theodorou, Dimitrios; Liapis, Nikolaos; Zannikos, Fanourios

    2013-02-15

    Sampling is an important part of any measurement process and is therefore recognized as an important contributor to the measurement uncertainty. A reliable estimation of the uncertainty arising from sampling of fuels leads to a better control of risks associated with decisions concerning whether product specifications are met or not. The present work describes and compares the results of three empirical statistical methodologies (classical ANOVA, robust ANOVA and range statistics) using data from a balanced experimental design, which includes duplicate samples analyzed in duplicate from 104 sampling targets (petroleum retail stations). These methodologies are used for the estimation of the uncertainty arising from the manual sampling of fuel (automotive diesel) and the subsequent sulfur mass content determination. The results of the three methodologies statistically differ, with the expanded uncertainty of sampling being in the range of 0.34-0.40 mg kg(-1), while the relative expanded uncertainty lying in the range of 4.8-5.1%, depending on the methodology used. The estimation of robust ANOVA (sampling expanded uncertainty of 0.34 mg kg(-1) or 4.8% in relative terms) is considered more reliable, because of the presence of outliers within the 104 datasets used for the calculations. Robust ANOVA, in contrast to classical ANOVA and range statistics, accommodates outlying values, lessening their effects on the produced estimates. The results of this work also show that, in the case of manual sampling of fuels, the main contributor to the whole measurement uncertainty is the analytical measurement uncertainty, with the sampling uncertainty accounting only for the 29% of the total measurement uncertainty. Copyright © 2012 Elsevier B.V. All rights reserved.

  11. On a model in radiation hydrodynamics

    OpenAIRE

    Ducomet, Bernard; Feireisl, Eduard; Nečasová, Šárka

    2011-01-01

    We consider a simplified model arising in radiation hydrodynamics based on the Navier–Stokes–Fourier system describing the macroscopic fluid motion, and a transport equation modeling the propagation of radiative intensity. We establish global-in-time existence for the associated initial–boundary value problem in the framework of weak solutions.

  12. Multiple ITS copies reveal extensive hybridization within Rheum (Polygonaceae), a genus that has undergone rapid radiation

    National Research Council Canada - National Science Library

    Wan, Dongshi; Sun, Yongshuai; Zhang, Xu; Bai, Xiaotao; Wang, Jun; Wang, Ailan; Milne, Richard

    2014-01-01

    During adaptive radiation events, characters can arise multiple times due to parallel evolution, but transfer of traits through hybridization provides an alternative explanation for the same character...

  13. Radiation Protection Research: Radiobiology

    Energy Technology Data Exchange (ETDEWEB)

    Desaintes, C

    2000-07-01

    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are (1) to study cancer mortality in nuclear workers in Belgium; to document the feasibility of retrospective cohort studies in Belgium; (2) to participate in the IARC study; (3) to elucidate the molecular basis of the effects of ionising radiation in the mammalian embryo during the early phases of its development; (4) to assess the genetic risk of maternal exposure to ionizing radiation; (5) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 1999 are reported.

  14. Unicentric Castleman's Disease Arising from an Intrapulmonary Lymph Node

    Directory of Open Access Journals (Sweden)

    Hideki Ota

    2013-01-01

    Full Text Available Castleman's disease is an uncommon lymphoproliferative disorder of unknown etiology, most often involving the mediastinum. It has 2 distinct clinical forms: unicentric and multicentric. Unicentric Castleman's disease arising from an intrapulmonary lymph node is rare, and establishing a preoperative diagnosis of this disease is very difficult mainly due to a lack of specific imaging features. We report a case of intrapulmonary unicentric Castleman's disease in an asymptomatic 19-year-old male patient who was accurately diagnosed by preoperative computed tomography (CT. The mass was incidentally found on a routine chest X-ray. A subsequent dynamic CT showed a well-defined, hypervascular, soft-tissue mass with small calcifications located in the perihilar area of the right lower lung. Three-dimensional CT (3D-CT angiography indicated that the mass was receiving its blood supply through a vascular network at its surface that originated from 2 right bronchial arteries. The clinical history and CT findings were consistent with a diagnosis of unicentric Castleman's disease, and we safely and successfully removed the tumor via video-assisted thoracoscopic surgical lobectomy. This case shows that the imaging characteristics of these rare tumors on contrast-enhanced CT combined with 3D-CT angiography can be helpful in reliably establishing a correct preoperative diagnosis.

  15. Massive odontoameloblastoma arising in the maxilla: a case report.

    Science.gov (United States)

    Kudoh, Masanori; Harada, Hiroyuki; Sato, Yuriko; Omura, Ken; Ishii, Yoshimasa

    2015-12-08

    Odontoameloblastoma is an extremely rare mixed odontogenic tumor with both epithelial and mesenchymal components. The term odontoameloblastoma first appeared in the 1971 World Health Organization classification (Pindborg JJ., et al.) and is defined as "a neoplasm that includes odontogenic ectomesenchyme in addition to odontogenic epithelium that resembles an ameloblastoma in both structures and behavior." Because of the aggressive nature and risk of recurrence of the tumor, complete resection is essential. In this report, we describe an extremely rare case of a patient with massive odontoameloblastoma arising in the maxilla and occupying maxillary sinus. In 2013, an 11-year-old Japanese boy was referred to our department for a painless and large mass of the right maxillary region. A panoramic X-ray showed a unilocular cystic lesion in the right maxilla containing a calcified mass in the lesion associated with an impacted tooth. Computed tomography showed a cystic lesion that included calcified structures and measured 3.6×3.1×2.7 cm. In 2013, the patient underwent tumor extirpation combined with impacted tooth extraction. The histopathological diagnosis was an odontoameloblastoma. No recurrence was noted 27 months after the operation. The patient has undergone postoperative occlusal guidance and functional orthodontic treatment, and his postoperative condition is excellent. However, postoperative recurrence or malignant transformation can occur in cases of odontoameloblastoma, and close long-term follow-up will be continued for our patient.

  16. Metabolic network modularity arising from simple growth processes.

    Science.gov (United States)

    Takemoto, Kazuhiro

    2012-09-01

    Metabolic networks consist of linked functional components, or modules. The mechanism underlying metabolic network modularity is of great interest not only to researchers of basic science but also to those in fields of engineering. Previous studies have suggested a theoretical model, which proposes that a change in the evolutionary goal (system-specific purpose) increases network modularity, and this hypothesis was supported by statistical data analysis. Nevertheless, further investigation has uncovered additional possibilities that might explain the origin of network modularity. In this work we propose an evolving network model without tuning parameters to describe metabolic networks. We demonstrate, quantitatively, that metabolic network modularity can arise from simple growth processes, independent of the change in the evolutionary goal. Our model is applicable to a wide range of organisms and appears to suggest that metabolic network modularity can be more simply determined than previously thought. Nonetheless, our proposition does not serve to contradict the previous model; it strives to provide an insight from a different angle in the ongoing efforts to understand metabolic evolution, with the hope of eventually achieving the synthetic engineering of metabolic networks.

  17. Thyroid gland metastasis arising from breast cancer: A case report.

    Science.gov (United States)

    Yang, Mei; Wang, Wei; Zhang, Chenfang

    2013-06-01

    The thyroid gland is an uncommon site for metastasis to develop and thus metastases arising from breast cancer are rarely observed. In the present study, we describe a case of a 45-year-old female with a three-year history of breast cancer who presented with a thyroid mass that was diagnosed as metastatic breast carcinoma by histopathological analysis of the subtotal thyroidectomy specimen. To ascertain the diagnosis of metastatic breast cancer, we evaluated two types of markers; those that possessed a similar expression status in the original and metastatic lesions [ER, PR and CerbB-2 (HER2/neu)], and those that are capable of differentiating between metastatic lesions and the surrounding thyroid components (TG and TTF-1). The results showed that ER, PR and CerbB-2 demonstrated a similar expression pattern in primary breast carcinoma and thyroid lesions. Meanwhile, in the thyroid lesions, the malignant cells showed negative staining for TG and TTF-1, which confirmed that lesions were not thyroid in origin. This case may prompt clinicians that although thyroid gland are uncommon metastatic site, a diagnosis of metastatic disease should be considered when new aggregates are identified in the thyroid glands and histopathological analysis may aid the diagnosis.

  18. Esophageal Adenocarcinoma Arising from Barrett's Epithelium in Taiwan

    Directory of Open Access Journals (Sweden)

    Chia-Hung Tu

    2007-08-01

    Full Text Available The prevalence of Barrett's esophagus (BE in Eastern countries is rising to match the prevalence in the West. However, a corresponding trend of BE-associated adenocarcinoma has yet to be observed in Asia. Historically, adenocarcinoma complicating BE has been considered a rare event in Taiwan. In the present report, we collected three Taiwanese cases of esophageal adenocarcinoma arising from BE. The first case was a 37-year-old man with an advanced cancer that developed on pre-existing BE after a 3-year interval without endoscopic surveillance. The second case was a 63-year-old man who presented with odynophagia and was found to have an ulcerative tumor centered on the characteristic Barrett's mucosa. The final case was a 44-year-old man who presented with gradual-onset dysphagia and weight loss, without typical reflux symptom. Our report emphasizes the need for an updated epidemiologic study to determine the incidence of BE-associated adenocarcinoma in Taiwan.

  19. Risk analysis for renewable energy projects due to constraints arising

    Science.gov (United States)

    Prostean, G.; Vasar, C.; Prostean, O.; Vartosu, A.

    2016-02-01

    Starting from the target of the European Union (EU) to use renewable energy in the area that aims a binding target of 20% renewable energy in final energy consumption by 2020, this article illustrates the identification of risks for implementation of wind energy projects in Romania, which could lead to complex technical implications, social and administrative. In specific projects analyzed in this paper were identified critical bottlenecks in the future wind power supply chain and reasonable time periods that may arise. Renewable energy technologies have to face a number of constraints that delayed scaling-up their production process, their transport process, the equipment reliability, etc. so implementing these types of projects requiring complex specialized team, the coordination of which also involve specific risks. The research team applied an analytical risk approach to identify major risks encountered within a wind farm project developed in Romania in isolated regions with different particularities, configured for different geographical areas (hill and mountain locations in Romania). Identification of major risks was based on the conceptual model set up for the entire project implementation process. Throughout this conceptual model there were identified specific constraints of such process. Integration risks were examined by an empirical study based on the method HAZOP (Hazard and Operability). The discussion describes the analysis of our results implementation context of renewable energy projects in Romania and creates a framework for assessing energy supply to any entity from renewable sources.

  20. Atmospheric dynamics InfraStructure in Europe: The ARISE project

    Science.gov (United States)

    Blanc, Elisabeth

    2013-04-01

    ARISE proposes to design a new infrastructure that integrates different station networks in order to provide a new "3D" image of the atmospheric dynamics from the ground up to the mesosphere with unprecedented spatio-temporal resolution. The implied networks are: - the International infrasound network developed for the verification of the Comprehensive nuclear Test Ban Treaty (CTBT). This system is unique by its quality for infrasound and atmospheric wave observations, - the Network for the Detection of Atmospheric Composition Changes (NDACC) which uses Lidar to measure stratospheric dynamics, - the Network for the Detection of Mesopause Changes (NDMC), dedicated to airglow layer measurements in the mesosphere, and additional complementary stations and satellite data. The infrastructure extends across Europe and outlying regions, including polar and equatorial regions. The measurements will be used to improve the parameterization of gravity waves in the stratosphere to better resolve climate models. Such description is crucial to estimate the impact of stratospheric climate forcing on the troposphere. In the long term, data will be used for monitoring changes in the occurrence of extreme events and trends in the middle atmosphere climate. The project impact also concerns civil applications related to monitoring of natural hazards as volcanoes. The presentation will focus on the first results obtained using three technologies during specific events as stratospheric warming, volcanic eruptions and severe weather. The benefits of using the three technologies will be discussed.

  1. Novel ethical dilemmas arising in geriatric clinical practice.

    Science.gov (United States)

    Calleja-Sordo, Elisa Constanza; de Hoyos, Adalberto; Méndez-Jiménez, Jorge; Altamirano-Bustamante, Nelly F; Islas-Andrade, Sergio; Valderrama, Alejandro; García-Peña, Carmen; Altamirano-Bustamante, Myriam M

    2015-05-01

    The purpose of this study is to determine empirically the state of the art of the medical care, when healthcare personal is confronted with ethical dilemmas related with the care they give to the geriatric population. An observational, longitudinal, prospective and qualitative study was conducted by analyzing the correlation between healthcare personnel-patient relationship, and ethical judgments regarding dilemmas that arise in daily clinical practice with geriatric patients. Mexican healthcare personnel with current active practices were asked to write up an ethical dilemma that arose frequently or that had impacted their medical practice. From the narrative input, we were able to draw up a database with 421 dilemmas, and those corresponding to patients 60 years and older were selected (n = 54, 12.8 %). The axiological analysis of the narrative dilemmas of geriatric patients was made using dialectical empiricism. The axiological analysis values found most frequently were classified into three groups: the impact of healthcare, the roles of the physician, and refusal of therapy; the healthcare role of educator, caring for the patients' life and the risk of imminent death where the values found more often. The persistence and universality of certain dilemmas in geriatrics calls for awareness and requires a good training in the ethical discernment of these dilemmas. This would help to improve substantially the care and the life quality of this population.

  2. A case of cystadenoma arising in the upper lip.

    Science.gov (United States)

    Onda, Takeshi; Hayashi, Kamichika; Takano, Nobuo; Matsuzaka, Kenichi; Shibahara, Takahiko

    2015-01-01

    Cystadenoma, a common benign tumor derived from glandular tissue, generally occurs in the appendix, ovaries, kidney, or pancreas. While rare in the oral and maxillofacial region, they do sometimes occur in the parotid or minor salivary glands. We report a case of cystadenoma arising in the upper lip region. The patient was a 37-year-old woman referred to our hospital with a painless mass on the left upper lip initially found during treatment at a local dental clinic. The medical history was non-contributory. The 7×5-mm mass was well-defined, elastic, and flexible. The surface of the mucosa appeared healthy. The mass was clinically diagnosed as a benign tumor of the left upper lip. Because the tumor was painless and slow-growing, and magnetic resonance imaging suggested that it was benign, resection was performed under local anesthesia without biopsy. Histopathologically, cystadenoma was diagnosed. No signs of recurrence or metastasis have been seen as of 24 months postoperatively and the progress of the patient has been satisfactory.

  3. Metaplastic Carcinoma with Chondroid Differentiation Arising in Microglandular Adenosis

    Directory of Open Access Journals (Sweden)

    Ga-Eon Kim

    2017-07-01

    Full Text Available Microglandular adenosis (MGA of the breast is a rare, benign proliferative lesion but with a significant rate of associated carcinoma. Herein, we report an unusual case of metaplastic carcinoma with chondroid differentiation associated with typical MGA. Histologically, MGA showed a direct transition to metaplastic carcinoma without an intervening atypical MGA or ductal carcinoma in situ component. The immunohistochemical profile of the metaplastic carcinoma was mostly similar to that of MGA. In both areas, all the epithelial cells were positive for S-100 protein, but negative for estrogen receptor, progesterone receptor, HER2/neu, and epidermal growth factor receptor. An increase in the Ki-67 and p53 labelling index was observed from MGA to invasive carcinoma. To the best of our knowledge, this is the first case of metaplastic carcinoma with chondroid differentiation arising in MGA in Korea. This case supports the hypothesis that a subset of MGA may be a non-obligate morphologic precursor of breast carcinoma, especially the triple-negative subtype.

  4. Mycobacterium fortuitum infection arising in a new tattoo.

    Science.gov (United States)

    Philips, Rebecca C; Hunter-Ellul, Lindsey A; Martin, Julie E; Wilkerson, Michael G

    2014-06-15

    We report an uncommon case of a cutaneous infection with Mycobacterium fortuitum arising in a new tattoo. A 29-year-old man presented with a several month history of a non-pruritic papular eruption within a tattoo; the papules developed 1-to-2 weeks after the tattoo procedure. He denied similar symptoms with previous tattoos. He had been treated unsuccessfully with cephalexin. Histopathologic examination revealed perifollicular chronic and granulomatous inflammation, consistent with chronic folliculitis. Acid-fast bacilli culture identified Mycobacterium fortuitum complex. The patient was treated with a 2-month course of oral trimethoprim-sulfamethoxazole (160mg/800mg twice daily) and ciprofloxacin (250 mg twice daily), with clinical improvement at follow up after three weeks of the antibiotic regimen. Rapidly growing mycobacteria have emerged as a cause of tattoo-associated cutaneous infection in recent years. Diagnosis and treatment can be difficult without clinical suspicion. M. fortuitum and other rapidly growing mycobacteria should be considered in the differential diagnosis of tattoo-associated dermatologic complications.

  5. Giant lipoma arising from deep lobe of the parotid gland

    Directory of Open Access Journals (Sweden)

    Hsu Ying-Che

    2006-06-01

    Full Text Available Abstract Background Lipomas are common benign soft tissue neoplasms but they are found very rarely in the deep lobe of parotid gland. Surgical intervention in these tumors is challenging because of the proximity of the facial nerve, and thus knowledge of the anatomy and meticulous surgical technique are essential. Case presentation A 71-year-old female presented with a large asymptomatic mass, which had occupied the left facial area for over the past fifteen years, and she requested surgical excision for a cosmetically better facial appearance. The computed tomography (CT scan showed a well-defined giant lipoma arising from the left deep parotid gland. The lipoma was successfully enucleated after full exposure and mobilization of the overlying facial nerve branches. The surgical specimen measured 9 × 6 cm in size, and histopathology revealed fibrolipoma. The patient experienced an uneventful recovery, with a satisfying facial contour and intact facial nerve function. Conclusion Giant lipomas involving the deep parotid lobe are extremely rare. The high-resolution CT scan provides an accurate and cost-effective preoperative investigative method. Surgical management of deep lobe lipoma should be performed by experienced surgeons due to the need for meticulous dissection of the facial nerve branches. Superficial parotidectomy before deep lobe lipoma removal may be unnecessary in selected cases because preservation of the superficial lobe may contribute to a better aesthetic and functional result.

  6. Primary Extraskeletal Mesenchymal Chondrosarcoma Arising from the Pancreas

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Bae Geun; Han, Yoon Hee; Lee, Byung Hoon; Kim, Su Young; Hwang, Yoon Joon; Seo, Jung Wook; Kim, Yong Hoon; Cha, Soon Joo; Hur, Gham; Joo, Mee [Inje University, School of Medicine, Goyang (Korea, Republic of)

    2007-12-15

    The CT scans showed a heterogeneously enhancing necrotic mass with numerous areas of coarse calcification, and this was located in the left side of the retroperitoneal space and involved the body and tail of the pancreas. Portal venography via the celiac axis also showed invasion of the splenic vein. It represents approximately 1% of all chondrosarcomas and it carries a poor prognosis. It can occur in extraskeletal locations and mainly in the soft tissues of the orbit, the cranial and spinal meningeal coverings and the lower limbs. To the best of our knowledge, there has been no reported case of primary extraskeletal mesenchymal chondrosarcoma of the pancreas. Only two instances of metastatic chondrosarcomas in the pancreas have been reported in the literature. We report here on a case of primary mesenchymal chondrosarcoma arising from the pancreas in a 41-year-old man. In summary, we present here a case of primary extraskeletal mesenchymal chondrosarcoma that arose from the pancreas. Radiologically, it manifested as a necrotic soft tissue mass with chondroid calcifications.

  7. Sparse gamma rhythms arising through clustering in adapting neuronal networks.

    Directory of Open Access Journals (Sweden)

    Zachary P Kilpatrick

    2011-11-01

    Full Text Available Gamma rhythms (30-100 Hz are an extensively studied synchronous brain state responsible for a number of sensory, memory, and motor processes. Experimental evidence suggests that fast-spiking interneurons are responsible for carrying the high frequency components of the rhythm, while regular-spiking pyramidal neurons fire sparsely. We propose that a combination of spike frequency adaptation and global inhibition may be responsible for this behavior. Excitatory neurons form several clusters that fire every few cycles of the fast oscillation. This is first shown in a detailed biophysical network model and then analyzed thoroughly in an idealized model. We exploit the fact that the timescale of adaptation is much slower than that of the other variables. Singular perturbation theory is used to derive an approximate periodic solution for a single spiking unit. This is then used to predict the relationship between the number of clusters arising spontaneously in the network as it relates to the adaptation time constant. We compare this to a complementary analysis that employs a weak coupling assumption to predict the first Fourier mode to destabilize from the incoherent state of an associated phase model as the external noise is reduced. Both approaches predict the same scaling of cluster number with respect to the adaptation time constant, which is corroborated in numerical simulations of the full system. Thus, we develop several testable predictions regarding the formation and characteristics of gamma rhythms with sparsely firing excitatory neurons.

  8. Hidden geometries in networks arising from cooperative self-assembly.

    Science.gov (United States)

    Šuvakov, Milovan; Andjelković, Miroslav; Tadić, Bosiljka

    2018-01-31

    Multilevel self-assembly involving small structured groups of nano-particles provides new routes to development of functional materials with a sophisticated architecture. Apart from the inter-particle forces, the geometrical shapes and compatibility of the building blocks are decisive factors. Therefore, a comprehensive understanding of these processes is essential for the design of assemblies of desired properties. Here, we introduce a computational model for cooperative self-assembly with the simultaneous attachment of structured groups of particles, which can be described by simplexes (connected pairs, triangles, tetrahedrons and higher order cliques) to a growing network. The model incorporates geometric rules that provide suitable nesting spaces for the new group and the chemical affinity of the system to accept excess particles. For varying chemical affinity, we grow different classes of assemblies by binding the cliques of distributed sizes. Furthermore, we characterize the emergent structures by metrics of graph theory and algebraic topology of graphs, and 4-point test for the intrinsic hyperbolicity of the networks. Our results show that higher Q-connectedness of the appearing simplicial complexes can arise due to only geometric factors and that it can be efficiently modulated by changing the chemical potential and the polydispersity of the binding simplexes.

  9. Ovarian Endometrioid Borderline Tumor Arising From an Endometriotic Cyst

    Directory of Open Access Journals (Sweden)

    Huzlinda Hussin

    2017-06-01

    Full Text Available Endometrioid borderline tumor of the ovary is defined as a solid or cystic tumor composed of crowded glands lined by atypical endometrioid type cells and lacking destructive stromal invasion and/or confluent glandular growth. In the literature, it was reported to comprise 2-19% of endometrioid tumors and 2-10% of all borderline tumors. The prognosis for ovarian endometrioid borderline tumor is excellent including that with features of intraepithelial carcinoma or microinvasion. Recurrences and metastases are extremely rare. A 34 years old Chinese lady presented with vaginal bleeding for many months. Intraoperatively, an intact right ovarian tumor measuring 55×10×10 mm was found. Cut sectioned showed a unilocular cyst with hemorrhagic fluid content and a solid tan nodule of 15 mm in diameter was found within the wall. Microscopically, the cystic ovarian tumor showed features of the endometriotic cyst and the solid nodule arising from the cyst wall showed an adenofibromatous pattern of an endometrioid borderline tumor. She also presented with disseminated endometriosis in the omentum and pelvic peritoneum. This kind of case was rarely reported for clinical reference especially on the macroscopic and microscopic features. [J Interdiscipl Histopathol 2017; 5(2.000: 58-59

  10. Radiation Therapy

    Science.gov (United States)

    Radiation therapy is a cancer treatment. It uses high doses of radiation to kill cancer cells and stop them from ... half of all cancer patients receive it. The radiation may be external, from special machines, or internal, ...

  11. Movement timing and invariance arise from several geometries.

    Directory of Open Access Journals (Sweden)

    Daniel Bennequin

    2009-07-01

    Full Text Available Human movements show several prominent features; movement duration is nearly independent of movement size (the isochrony principle, instantaneous speed depends on movement curvature (captured by the 2/3 power law, and complex movements are composed of simpler elements (movement compositionality. No existing theory can successfully account for all of these features, and the nature of the underlying motion primitives is still unknown. Also unknown is how the brain selects movement duration. Here we present a new theory of movement timing based on geometrical invariance. We propose that movement duration and compositionality arise from cooperation among Euclidian, equi-affine and full affine geometries. Each geometry posses a canonical measure of distance along curves, an invariant arc-length parameter. We suggest that for continuous movements, the actual movement duration reflects a particular tensorial mixture of these canonical parameters. Near geometrical singularities, specific combinations are selected to compensate for time expansion or compression in individual parameters. The theory was mathematically formulated using Cartan's moving frame method. Its predictions were tested on three data sets: drawings of elliptical curves, locomotion and drawing trajectories of complex figural forms (cloverleaves, lemniscates and limaçons, with varying ratios between the sizes of the large versus the small loops. Our theory accounted well for the kinematic and temporal features of these movements, in most cases better than the constrained Minimum Jerk model, even when taking into account the number of estimated free parameters. During both drawing and locomotion equi-affine geometry was the most dominant geometry, with affine geometry second most important during drawing; Euclidian geometry was second most important during locomotion. We further discuss the implications of this theory: the origin of the dominance of equi-affine geometry, the possibility

  12. Fast multipole preconditioners for sparse matrices arising from elliptic equations

    KAUST Repository

    Ibeid, Huda

    2017-11-09

    Among optimal hierarchical algorithms for the computational solution of elliptic problems, the fast multipole method (FMM) stands out for its adaptability to emerging architectures, having high arithmetic intensity, tunable accuracy, and relaxable global synchronization requirements. We demonstrate that, beyond its traditional use as a solver in problems for which explicit free-space kernel representations are available, the FMM has applicability as a preconditioner in finite domain elliptic boundary value problems, by equipping it with boundary integral capability for satisfying conditions at finite boundaries and by wrapping it in a Krylov method for extensibility to more general operators. Here, we do not discuss the well developed applications of FMM to implement matrix-vector multiplications within Krylov solvers of boundary element methods. Instead, we propose using FMM for the volume-to-volume contribution of inhomogeneous Poisson-like problems, where the boundary integral is a small part of the overall computation. Our method may be used to precondition sparse matrices arising from finite difference/element discretizations, and can handle a broader range of scientific applications. It is capable of algebraic convergence rates down to the truncation error of the discretized PDE comparable to those of multigrid methods, and it offers potentially superior multicore and distributed memory scalability properties on commodity architecture supercomputers. Compared with other methods exploiting the low-rank character of off-diagonal blocks of the dense resolvent operator, FMM-preconditioned Krylov iteration may reduce the amount of communication because it is matrix-free and exploits the tree structure of FMM. We describe our tests in reproducible detail with freely available codes and outline directions for further extensibility.

  13. Sewage sludge - arisings, composition, disposal capacities; Klaerschlamm - Mengen, Zusammensetzung, Entsorgungskapazitaeten

    Energy Technology Data Exchange (ETDEWEB)

    Faulstich, M.; Rabus, J. [Technische Univ. Muenchen, Garching (Germany). Lehrstuhl fuer Wasserguete- und Abfallwirtschaft; Urban, A.I.; Friedel, M. [Kassel Univ. (Gesamthochschule) (Germany). Fachgebiet Abfalltechnik

    1998-09-01

    One of the main disposal paths for sewage sludge in the past was landfilling. This option was severely restricted by the issue of the Technical Code on Household Waste in 1993. In its agricultural applications sewage sludge serves as a fertiliser and a soil improvement agent. Estimates on potential thermal treatment capacities have shown that there are enough public power plants to accommodate and provide thermal treatment for the total of sewage sludge arisings in Germany. As can be seen from the estimates presented in this paper, it would not even be necessary to restrict oneself to public power plant capacities. The paper points out possibilities of using plant capacities already existing in industrial firing plants and certain production sectors. It uses a comparison to show that sewage sludge would have to be dried in order to permit its thermal treatment in these private facilities. Aside from this, there are a number of new techniques entering the market which from the technical viewpoint also appear to be well suited for thermal sewage sludge treatment. [Deutsch] Ein wesentlicher Entsorgungsweg von Klaerschlamm war in der Vergangenheit die Verbringung auf eine Deponie. Diese Moeglichkeit ist durch die TA Siedlungsabfall von 1993 stark eingeschraenkt. Bei der landwirtschaftlichen Verwertung wird durch den Klaerschlamm eine Duengewirkung sowie eine Bodenverbesserung erreicht. Eine Abschaetzung der potentiellen thermischen Behandlungskapazitaeten zeigt, dass die gesamte bundesdeutsche Klaerschlammenge in oeffentlichen Kraftwerken unterzubringen und thermisch zu behandeln waere. Wie die hier dargestellten Abschaetzungen gezeigt haben, ist man durchaus nicht allein auf die Nutzung oeffentlicher Kraftwerkskapazitaeten angewiesen. Es wurden Moeglichkeiten zur Nutzung vorhandener Anlagenkapazitaeten in industriellen Feuerungsanlagen und in Produktionsbereichen aufgezeigt. Wie aus einem Vergleich erkennbar wird, ist allerdings eine Trocknung der Klaerschlaemme

  14. Obesity, the endocannabinoid system, and bias arising from pharmaceutical sponsorship.

    Directory of Open Access Journals (Sweden)

    John M McPartland

    Full Text Available BACKGROUND: Previous research has shown that academic physicians conflicted by funding from the pharmaceutical industry have corrupted evidence based medicine and helped enlarge the market for drugs. Physicians made pharmaceutical-friendly statements, engaged in disease mongering, and signed biased review articles ghost-authored by corporate employees. This paper tested the hypothesis that bias affects review articles regarding rimonabant, an anti-obesity drug that blocks the central cannabinoid receptor. METHODS/PRINCIPAL FINDINGS: A MEDLINE search was performed for rimonabant review articles, limited to articles authored by USA physicians who served as consultants for the company that manufactures rimonabant. Extracted articles were examined for industry-friendly bias, identified by three methods: analysis with a validated instrument for monitoring bias in continuing medical education (CME; analysis for bias defined as statements that ran contrary to external evidence; and a tally of misrepresentations about the endocannabinoid system. Eight review articles were identified, but only three disclosed authors' financial conflicts of interest, despite easily accessible information to the contrary. The Takhar CME bias instrument demonstrated statistically significant bias in all the review articles. Biased statements that were nearly identical reappeared in the articles, including disease mongering, exaggerating rimonabant's efficacy and safety, lack of criticisms regarding rimonabant clinical trials, and speculations about surrogate markers stated as facts. Distinctive and identical misrepresentations regarding the endocannabinoid system also reappeared in articles by different authors. CONCLUSIONS: The findings are characteristic of bias that arises from financial conflicts of interest, and suggestive of ghostwriting by a common author. Resolutions for this scenario are proposed.

  15. Movement Timing and Invariance Arise from Several Geometries

    Science.gov (United States)

    Bennequin, Daniel; Fuchs, Ronit; Berthoz, Alain; Flash, Tamar

    2009-01-01

    Human movements show several prominent features; movement duration is nearly independent of movement size (the isochrony principle), instantaneous speed depends on movement curvature (captured by the 2/3 power law), and complex movements are composed of simpler elements (movement compositionality). No existing theory can successfully account for all of these features, and the nature of the underlying motion primitives is still unknown. Also unknown is how the brain selects movement duration. Here we present a new theory of movement timing based on geometrical invariance. We propose that movement duration and compositionality arise from cooperation among Euclidian, equi-affine and full affine geometries. Each geometry posses a canonical measure of distance along curves, an invariant arc-length parameter. We suggest that for continuous movements, the actual movement duration reflects a particular tensorial mixture of these canonical parameters. Near geometrical singularities, specific combinations are selected to compensate for time expansion or compression in individual parameters. The theory was mathematically formulated using Cartan's moving frame method. Its predictions were tested on three data sets: drawings of elliptical curves, locomotion and drawing trajectories of complex figural forms (cloverleaves, lemniscates and limaçons, with varying ratios between the sizes of the large versus the small loops). Our theory accounted well for the kinematic and temporal features of these movements, in most cases better than the constrained Minimum Jerk model, even when taking into account the number of estimated free parameters. During both drawing and locomotion equi-affine geometry was the most dominant geometry, with affine geometry second most important during drawing; Euclidian geometry was second most important during locomotion. We further discuss the implications of this theory: the origin of the dominance of equi-affine geometry, the possibility that the brain

  16. Dracunculiasis eradication--finishing the job before surprises arise.

    Science.gov (United States)

    Visser, Benjamin Jelle

    2012-07-01

    Dracunculiasis (Guinea worm disease) is a preventable waterborne parasitic disease that affects the poorest people living in remote rural areas in sub-Saharan African countries, who do not have access to safe drinking water. The Guinea Worm Eradication Program, a 25-year old campaign to rid the world of Guinea Worm disease has now reached its final stage accelerating to zero cases in all endemic countries. During the 19th and 20th centuries, dracunculiasis was common in much of Southern Asia and the African continent. The overall number of cases has been reduced tremendously by ≥99%, from the 3.32 million cases estimated to have occurred in 1986 in Africa to only 1,797 cases reported in 2010 reported in only five countries (Sudan, Mali, Ethiopia, Chad and Ghana) and Asia free of the disease. This achievement is unique in its kind--the only previously eradicated disease is smallpox, a viral infection for which vaccination was possible--and it has been achieved through primary community-based prevention and health education programs. Most efforts need to be taken in two countries, South Sudan (comprising 94% or 1,698 out of 1,797 of the cases reported world-wide in 2010) and Mali because of frequent movements of nomads in a vast area inside and outside Mali's borders. All factors favourable to dracunculiasis eradication are available including adequate financial resources, community and political support and high levels of advocacy. Thus there is no reason that this disabling parasitic disease cannot be eradicated soon before surprises arise such as new civil conflicts in currently endemic countries. Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

  17. Radiation dosimetry

    CERN Document Server

    Hine, Gerald J; Hine, Gerald J

    1956-01-01

    Radiation Dosimetry focuses on the advancements, processes, technologies, techniques, and principles involved in radiation dosimetry, including counters and calibration and standardization techniques. The selection first offers information on radiation units and the theory of ionization dosimetry and interaction of radiation with matter. Topics include quantities derivable from roentgens, determination of dose in roentgens, ionization dosimetry of high-energy photons and corpuscular radiations, and heavy charged particles. The text then examines the biological and medical effects of radiation,

  18. Single Molecule Scanning of DNA Radiation Oxidative Damage Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal will develop an assay to map genomic DNA, at the single molecule level and in a nanodevice, for oxidative DNA damage arising from radiation exposure;...

  19. Radiation Therapy: Professions in Radiation Therapy

    Science.gov (United States)

    ... Resources Professions Site Index A-Z Professions in Radiation Therapy Radiation Oncologist Therapeutic Medical Physicist Radiation Therapist Dosimetrist Radiation Oncology Nurse Social Worker Dietitian Radiation Oncologist Radiation oncologists are physicians who oversee the ...

  20. Radiation-induced leiomyosarcoma of the oropharynx

    Directory of Open Access Journals (Sweden)

    Maier Wolfgang

    2006-08-01

    Full Text Available Abstract Leiomyosarcoma is a malignant mesenchymal tumor originating from smooth muscle cells, which most frequently develops in the myometrium and in the gastro-intestinal tract. Reviewing the international literature, radiation-induced sarcoma arise in 0.035 to 0.2 % of all irradiated patients. Especially in the head and neck region, radiation-induced leiomyosarcoma is an extremely rare lesion. The authors report a case of a radiation-induced leiomyosarcoma of the tonsillar region of the oropharynx in a 51-year-old male patient, who had undergone radiation therapy of this region 38 years before. The lesion was treated by radical surgery. Diagnostic steps, histological presentation and therapy are described in detail and the literature concerning radiation induced malignancies in general as well as radiation induced leiomyosarcoma in particular is reviewed. The highlights of this case are an extremely uncommon location and a rare pathological entity of radiation induced malignancies.

  1. Plasma scattering of electromagnetic radiation

    CERN Document Server

    Sheffield, John

    1975-01-01

    Plasma Scattering of Electromagnetic Radiation covers the theory and experimental application of plasma scattering. The book discusses the basic properties of a plasma and of the interaction of radiation with a plasma; the relationship between the scattered power spectrum and the fluctuations in plasma density; and the incoherent scattering of low-temperature plasma. The text also describes the constraints and problems that arise in the application of scattering as a diagnostic technique; the characteristic performance of various dispersion elements, image dissectors, and detectors; and the ge

  2. RADIATION ACOUSTICS

    OpenAIRE

    Lyamshev, L.

    1990-01-01

    Radiation acoustics is a new branch of acoustics. Its' fundamentals are lying in the research of acoustical effects due to the interaction of a radiation with matter. The sound excitation in liquids and solids by modulated or pulsed particle beams (electron, proton, ion beams, γ-radiation and single high-energy elementary particles) and some practical applications are discussed.

  3. Ewing sarcoma-family tumors that arise after treatment of primary childhood cancer.

    Science.gov (United States)

    Spunt, Sheri L; Rodriguez-Galindo, Carlos; Fuller, Christine E; Harper, JoAnn; Krasin, Matthew J; Billups, Catherine A; Khoury, Joseph D

    2006-07-01

    Unlike osteosarcoma, the Ewing sarcoma family of tumors (ESFT) has rarely been reported as secondary malignant neoplasms after treatment of childhood cancer. ESFT arising as a second cancer was reviewed and characterized at our childhood cancer center. A retrospective review was undertaken of 11,183 patients age <21 years who were treated for a primary cancer between March 1962 and December 2003 at St. Jude Children's Research Hospital. All cases of ESFT were confirmed to have a rearranged EWS gene. Six cases of ESFT (1.3% of 479 second cancers) were identified in patients previously treated for lymphoma (n = 3), leukemia (n = 1), retinoblastoma (n = 1), or Wilms tumor (n = 1). None of these patients had a family history suggestive of a familial cancer syndrome. The median time between diagnosis of primary cancer and diagnosis of ESFT was 5.9 years (range, 3.1-18.3 years). ESFT occurred in typical anatomic locations: rib (n = 2), chest wall soft tissues (n = 2), pelvis (n = 1), and extremity (n = 1). One tumor arose at the margin of a previous radiotherapy field and 1 arose distant from previous radiotherapy fields; all other patients had not received radiotherapy. Three patients are alive at the time of this report, including 2 whose ESFT was diagnosed more than 8 years ago. ESFT occurs rarely after treatment of a primary cancer during childhood, and most cases do not appear to be related to radiation therapy. Long-term survival can be achieved in some patients, and therefore secondary ESFT should be treated with curative intent. Copyright 2006 American Cancer Society.

  4. Rhabdomyosarcoma Arising in a Previously Irradiated Field: An Analysis of 43 Patients

    Energy Technology Data Exchange (ETDEWEB)

    Dang, Nguyen D. [Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas (United States); Teh, Bin S. [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States); Paulino, Arnold C., E-mail: apaulino@tmhs.org [Department of Radiation Oncology, The Methodist Hospital and Methodist Hospital Research Institute, Houston, Texas (United States)

    2013-03-01

    Patients with soft tissue sarcomas that arise from previously irradiated fields have traditionally been reported to have a poor prognosis. In this report, we examined the characteristics and outcomes of patients who developed a rhabdomyosarcoma in a previously irradiated field (RMS-RIF); we hypothesize that these patients should have a better outcome compared to other postradiation soft tissue sarcomas as these tumors are chemosensitive and radiosensitive. A PubMed search of the literature from 1961-2010 yielded 33 studies with data for patients with RMS-RIF. The study included 43 patients with a median age of 6.5 years at the time of radiation therapy (RT) for the initial tumor. The median RT dose was 48 Gy. The median latency period, the time from RT to development of RMS-RIF, was 8 years. The 3-year overall survival for RMS-RIF was 42%. The 3-year overall survival was 66% for patients receiving chemotherapy and local treatment (surgery and/or RT) compared to 29% for those who had systemic treatment only or local treatment only (P=.049). Other factors associated with increased 3-year overall survival included retinoblastoma initial diagnosis (P<.001), age ≤18 years at diagnosis of RMS-RIF (P=.003), favorable site (P=.008), and stage 1 disease (P=.002). Age at time of RMS-RIF, retinoblastoma initial tumor, favorable site, stage 1 disease, and use of both systemic and local treatment were found to be favorable prognostic factors for 3-year overall survival.

  5. Radiation shielding concrete made of Basalt aggregates.

    Science.gov (United States)

    Alhajali, S; Yousef, S; Kanbour, M; Naoum, B

    2013-04-01

    In spite of the fact that Basalt is a widespread type of rock, there is very little available information on using it as aggregates for concrete radiation shielding. This paper investigates the possibility of using Basalt for the aforementioned purpose. The results have shown that Basalt could be used successfully for preparing radiation shielding concrete, but some attention should be paid to the choice of the suitable types of Basalt and for the neutron activation problem that could arise in the concrete shield.

  6. Radiation hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Pomraning, G.C.

    1982-12-31

    This course was intended to provide the participant with an introduction to the theory of radiative transfer, and an understanding of the coupling of radiative processes to the equations describing compressible flow. At moderate temperatures (thousands of degrees), the role of the radiation is primarily one of transporting energy by radiative processes. At higher temperatures (millions of degrees), the energy and momentum densities of the radiation field may become comparable to or even dominate the corresponding fluid quantities. In this case, the radiation field significantly affects the dynamics of the fluid, and it is the description of this regime which is generally the charter of radiation hydrodynamics. The course provided a discussion of the relevant physics and a derivation of the corresponding equations, as well as an examination of several simplified models. Practical applications include astrophysics and nuclear weapons effects phenomena.

  7. Atoms, Radiation, and Radiation Protection

    CERN Document Server

    Turner, James E

    2007-01-01

    Atoms, Radiation, and Radiation Protection offers professionals and advanced students a comprehensive coverage of the major concepts that underlie the origins and transport of ionizing radiation in matter. Understanding atomic structure and the physical mechanisms of radiation interactions is the foundation on which much of the current practice of radiological health protection is based. The work covers the detection and measurement of radiation and the statistical interpretation of the data. The procedures that are used to protect man and the environment from the potential harmful effects of

  8. Epicardial Ablation of Focal Atrial Tachycardia Arising From Left Atrial Appendage in Children

    Directory of Open Access Journals (Sweden)

    Abdhija Hanumandla

    2014-07-01

    Full Text Available Focal left atrial tachycardia (FLAT although a common cause of supraventricular tachycardia(SVT among children, the one's arising from left atrial appendage (LAA present a unique challenge for successful ablation because of anatomical location. We present two children with FLAT arising from the epicardial LAA, successfully mapped and ablated through percutaneuous epicardial approach.

  9. 31 CFR 535.335 - Claim arising out of events in Iran.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Claim arising out of events in Iran. 535.335 Section 535.335 Money and Finance: Treasury Regulations Relating to Money and Finance... General Definitions § 535.335 Claim arising out of events in Iran. For purposes of § 535.216, a claim is...

  10. Radiation Chemistry

    Science.gov (United States)

    Wojnárovits, L.

    Ionizing radiation causes chemical changes in the molecules of the interacting medium. The initial molecules change to new molecules, resulting in changes of the physical, chemical, and eventually biological properties of the material. For instance, water decomposes to its elements H2 and O2. In polymers, degradation and crosslinking take place. In biopolymers, e.g., DNS strand breaks and other alterations occur. Such changes are to be avoided in some cases (radiation protection), however, in other cases they are used for technological purposes (radiation processing). This chapter introduces radiation chemistry by discussing the sources of ionizing radiation (radionuclide sources, machine sources), absorption of radiation energy, techniques used in radiation chemistry research, and methods of absorbed energy (absorbed dose) measurements. Radiation chemistry of different classes of inorganic (water and aqueous solutions, inorganic solids, ionic liquids (ILs)) and organic substances (hydrocarbons, halogenated compounds, polymers, and biomolecules) is discussed in concise form together with theoretical and experimental backgrounds. An essential part of the chapter is the introduction of radiation processing technologies in the fields of polymer chemistry, food processing, and sterilization. The application of radiation chemistry to nuclear technology and to protection of environment (flue gas treatment, wastewater treatment) is also discussed.

  11. Solar ultraviolet radiation in a changing climate

    Science.gov (United States)

    The projected large increases in damaging ultraviolet radiation as a result of global emissions of ozone-depleting substances have been forestalled by the success of the Montreal Protocol. New challenges are now arising in relation to climate change. We highlight the complex inte...

  12. Radiation carcinogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.

    1976-01-01

    The risk of iatrogenic tumors with radiation therapy is so outweighed by the benefit of cure that estimates of risk have not been considered necessary. However, with the introduction of chemotherapy, combined therapy, and particle radiation therapy, the comparative risks should be examined. In the case of radiation, total dose, fractionation, dose rate, dose distribution, and radiation quality should be considered in the estimation of risk. The biological factors that must be considered include incidence of tumors, latent period, degree of malignancy, and multiplicity of tumors. The risk of radiation induction of tumors is influenced by the genotype, sex, and age of the patient, the tissues that will be exposed, and previous therapy. With chemotherapy the number of cells at risk is usually markedly higher than with radiation therapy. Clearly the problem of the estimation of comparative risks is complex. This paper presents the current views on the comparative risks and the importance of the various factors that influence the estimation of risk.

  13. GRAVITATIONAL RADIATION

    Directory of Open Access Journals (Sweden)

    Metin SALTIK

    1996-03-01

    Full Text Available According to classical electromagnetic theory, an accelerated charge or system of charges radiates electromagnetic waves. In a radio transmitter antenna charges are accelerated along the antenna and release electromagnetic waves, which is radiated at the velocity of light in the surrounding medium. All of the radio transmitters work on this principle today. In this study an analogy is established between the principles by which accelerated charge systems markes radiation and the accelerated mass system, and the systems cousing gravitational radiation are investigated.

  14. Differences in Radiation Dosimetry and Anorectal Function Testing Imply That Anorectal Symptoms May Arise From Different Anatomic Substrates

    Energy Technology Data Exchange (ETDEWEB)

    Smeenk, Robert Jan, E-mail: r.smeenk@rther.umcn.nl [Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen (Netherlands); Hopman, Wim P.M. [Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen (Netherlands); Hoffmann, Aswin L.; Lin, Emile N.J.Th. van; Kaanders, Johannes H.A.M. [Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen (Netherlands)

    2012-01-01

    Purpose: To explore the influence of functional changes and dosimetric parameters on specific incontinence-related anorectal complaints after prostate external beam radiotherapy and to estimate dose-effect relations for the anal wall and rectal wall. Methods and Materials: Sixty patients, irradiated for localized prostate cancer, underwent anorectal manometry and barostat measurements to evaluate anal pressures, rectal capacity, and rectal sensory functions. In addition, 30 untreated men were analyzed as a control group. In 36 irradiated patients, the anal wall and rectal wall were retrospectively delineated on planning computed tomography scans, and dosimetric parameters were retrieved from the treatment plans. Functional and dosimetric parameters were compared between patients with and without complaints, focusing on urgency, incontinence, and frequency. Results: After external beam radiotherapy, reduced anal pressures and tolerated rectal volumes were observed, irrespective of complaints. Patients with urgency and/or incontinence showed significantly lower anal resting pressures (mean 38 and 39 vs. 49 and 50 mm Hg) and lower tolerated rectal pressures (mean 28 and 28 vs. 33 and 34 mm Hg), compared to patients without these complaints. In patients with frequency, almost all rectal parameters were reduced. Several dosimetric parameters to the anal wall and rectal wall were predictive for urgency (e.g., anal D{sub mean}>38Gy), whereas some anal wall parameters correlated to incontinence and no dose-effect relation for frequency was found. Conclusions: Anorectal function deteriorates after external beam radiotherapy. Different incontinence-related complaints show specific anorectal dysfunctions, suggesting different anatomic and pathophysiologic substrates: urgency and incontinence seem to originate from both anal wall and rectal wall, whereas frequency seems associated with rectal wall dysfunction. Also, dose-effect relations differed between these complaints. This implies that anal wall and rectal wall should be considered separate organs in radiotherapy planning.

  15. Endometrial Stromal Sarcoma Arising in Colorectal Endometriosis: A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Qiao Wang

    2015-01-01

    Full Text Available Extrauterine endometrial stromal sarcoma (ESS arising in endometriosis is extremely rare, particularly in the colorectum. It should always be included in the differential diagnosis of primary tumors originating from gastrointestinal tract in females, given that preoperative endoscopical biopsy may reveal no specific changes. We reported a case of ESS arising in colorectal endometriosis and reviewed the previous 7 cases reported in the English literature. Our patient, who was unavailable for tumor resection and refused further adjuvant therapy, played a role in representing the natural history of low-grade extragenital ESS. This case was the only death from ESS arising in colorectal endometriosis.

  16. Radiation Protection

    Energy Technology Data Exchange (ETDEWEB)

    Loos, M

    2002-04-01

    Major achievements of SCK-CEN's Radiation Protection Department in 2001 are described. The main areas for R and D of the department are enviromnental remediation, emergency planning, radiation protection research, low-level radioactvity measurements, safeguards and physics measurements, decision strategy research and policy support and social sciences in nuclear research. Main achievements for 2001 in these areas are reported.

  17. Dedifferentiated chondrosarcoma arising in fibrous dysplasia: A case report and review of the current literature

    Directory of Open Access Journals (Sweden)

    Nicole MD Riddle

    2009-06-01

    Full Text Available Nicole MD Riddle1, Hideko Yamauchi2, Jamie T Caracciolo4, David Johnson2, G Douglas Letson2, Ardeshir Hakam1,3, Prudence V Smith1,2,3, Marilyn M Bui1,2,31Department of Pathology and Cell Biology, University of South Florida, Tampa, FL, USA; 2Department of Sarcoma, 3Department of Anatomic Pathology, 4Department of Radiology, Moffitt Cancer Center, Tampa, FL, USABackground: Fibrous dysplasia is an uncommon bone disease that has rare but clear potential for malignant transformation. The frequency is increased in polyostotic forms, McCune–Albright syndrome, Mazabraud’s syndrome, and previously irradiated sites. Rapidly progressing pain unrelated to trauma is the most concerning symptom. The early radiological features of sarcomatous transformation are moth-eaten or cystic areas of osteolysis, cortical destruction, and gradual formation of a soft tissue mass. The prognosis is unfavorable as most of the cases are in an advanced stage at the time of diagnosis.Methods: This case was diagnosed at a large cancer center in Florida. Pertinent clinical findings were obtained from chart review and inter-departmental consultation.Results: Histopathological examination revealed dysplastic lamellar bone with no osteoblastic rimming and “Chinese letter” shapes, areas composed of lobulated hyaline cartilage with mild to severe nuclear atypia, and areas of poorly differentiated cells with a spindled appearance, consistent with chondrosarcoma arising within fibrous dysplasia.Conclusions: Sarcomatous transformation of fibrous dysplasia is an uncommon occurrence, yet has significant importance for those with the disease. There may be difficulty with diagnosis given the symptoms and radiologic findings of benign fibrous dysplasia. We report a case of chondrosarcoma rising in fibrous dysplasia and review the current literature. This case is of interest due to the fact that the diagnosis of monostotic fibrous dysplasia was first made at the age of 59 and

  18. Radiative light dark matter

    Science.gov (United States)

    Dedes, A.; Karamitros, D.; Pilaftsis, A.

    2017-06-01

    We present a Peccei-Quinn (PQ)-symmetric two-Higgs doublet model that naturally predicts a fermionic singlet dark matter in the mass range 10 keV-1 GeV. The origin of the smallness of the mass of this light singlet fermion arises predominantly at the one-loop level, upon soft or spontaneous breakdown of the PQ symmetry via a complex scalar field in a fashion similar to the so-called Dine-Fischler-Sredniki-Zhitnitsky axion model. The mass generation of this fermionic radiative light dark matter (RLDM) requires the existence of two heavy vectorlike SU(2) isodoublets, which are not charged under the PQ symmetry. We show how the RLDM can be produced via the freeze-in mechanism, thus accounting for the missing matter in the Universe. Finally, we briefly discuss possible theoretical and phenomenological implications of the RLDM model for the strong C P problem and the CERN Large Hadron Collider (LHC).

  19. 32 CFR 536.136 - Scope for claims arising under the Foreign Claims Act.

    Science.gov (United States)

    2010-07-01

    ... member of the U.S. armed forces, a U.S. civilian employee, or a family member of either category. In a... noncombat activities of the armed forces. (b) Effect of Military Claims Act (MCA). Claims arising in foreign...

  20. Squamous cell carcinoma arising within a maxillary odontogenic keratocyst: A rare occurrence

    Energy Technology Data Exchange (ETDEWEB)

    Jalali, Elnaz [Eliray Oral and Maxillofacial Radiology Consulting Services, Miami (United States); Tadinada, Aditya; Rengasamy, Kandasamy; Ferneini, Elie M. [University of Connecticut, School of Dental Medicine, Farmington (United States)

    2017-06-15

    Squamous cell carcinoma (SCC) arising within the lining of an odontogenic keratocyst (OKC) is a rare occurrence. Although potentially locally destructive, OKC is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. We present the clinical and radiographic features of a maxillary mass that demonstrated SCC arising from the lining of an OKC. Although the initial clinical and radiographic presentation suggested an infection or malignant neoplasm, biopsies revealed an infiltrative well-differentiated SCC contiguous with and arising from the focus of a pre-existing OKC. The patient subsequently underwent a type II hemi-maxillectomy with neoadjuvant chemoradiation. This report discusses the clinical and radiographic features associated with intraosseous malignancies, especially those arising from an otherwise benign odontogenic lesion. While the majority of OKCs are benign, the current report illustrates the potential for carcinomatous transformation within the lining of an OKC.

  1. Cryoablation of ventricular tachycardia arising from the left-coronary sinus cusp.

    Science.gov (United States)

    Uppu, Santosh C; Tuzcu, Volkan

    2013-03-01

    Ventricular tachycardia (VT) arising from the coronary sinus cusps and mimicking right-ventricular morphology is a rare entity. In this report, we report the successful cryoablation of left-coronary sinus cusp VT.

  2. Tall cell variant of papillary carcinoma arising from strumaovarii: A rare case report

    Directory of Open Access Journals (Sweden)

    Kavita Mardi

    2013-01-01

    Full Text Available Struma ovarii is the presence of thyroid tissue as the major cellular component in an ovarian tumour. Papillary carcinoma in strumaovarii is exceptionally rare. A tall cell variant of papillary carcinoma arising from a strumaovarii has not been reported so far. We present a case of a 40-year-old female with a tall cell variant of papillary carcinoma arising in strumaovarii.

  3. Multi-focal lobular carcinoma in situ arising in benign phylodes tumor: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Taeg Ki; Choi, Chang Hwan; Kim, Youn Jeong; Kim, Mi Young; Lee, Kyung Hee; Cho, Soon Gu [Inha University Hospital, Incheon (Korea, Republic of)

    2015-08-15

    Coexistent breast malignancy arising in phyllodes tumor is extremely rare, and most of them are incidental reports after surgical excision. Coexistent malignancy in phyllodes tumor can vary from in-situ to invasive carcinoma. Lobular neoplasia is separated into atypical lobular hyperplasia and lobular carcinoma in situ (LCIS). LCIS is known to have a higher risk of developing invasive cancer. We reported imaging findings of multifocal LCIS arising in benign phyllodes tumor.

  4. Eccrine syringofibroadenoma arising in peristomal skin: a report of two cases.

    Science.gov (United States)

    Clarke, Loren E; Ioffreda, Michael; Abt, Arthur B

    2003-01-01

    Eccrine syringofibroadenoma (ESFA) is a benign neoplasm arising from the intraepidermal portion of eccrine ducts. It is characterized by a distinctive histologic pattern of epithelial cells arranged in anastomosing cords surrounded by a fibrovascular stroma. Approximately 50 cases of ESFA have been reported, and in recent years the lesion has been described occurring in association with other skin conditions. We report 2 cases of ESFA arising in abdominal skin adjacent to enterostomy sites.

  5. Radiation shield

    Energy Technology Data Exchange (ETDEWEB)

    Nemezawa, Isao; Kimura, Tadahiro [Hitachi Ltd., Tokyo (Japan); Omori, Tetsu; Mizuochi, Akira

    1997-11-18

    A radiation shield is constituted by using a flexible bag made of a synthetic resin, a rubber plate or a composite member of them. Water is charged therein as a shielding liquid. Water injection ports are formed at the lower surface, and gas exhaustion ports are formed on the upper surface of the radiation shield. A plurality of vertical ribs made of the same material as the bag of the radiation shield are formed, integral with the bag, each at a space on the outer surface of the radiation shield. A reinforcing tube are inserted to the vertical ribs integral with the bag. The reinforcing tube may be made of an metal or non-metal material, but material having a bending strength greater than that of the bag is used. When wide surfaces are constituted in the horizontal direction as radiation shielding surfaces, a plurality of the radiation shields are used being in adjacent in the horizontal direction. The reinforcing tubes in adjacent with each other among the adjacent radiation shields are connected by connectors. (I.N.)

  6. Malignancy arising within cutaneous tattoos: case of dermatofibrosarcoma protuberans and review of literature.

    Science.gov (United States)

    Reddy, Kavitha K; Hanke, C William; Tierney, Emily P

    2011-08-01

    Dermatofibrosarcoma protuberans (DFSP) is an uncommon tumor of the skin with high rates of local recurrence. Several reports describe a frequent history of local trauma. In one prior case, a DFSP arising in a tattoo site has been reported. Mohs micrographic surgery (MMS) has been used successfully for treatment. To present a case of dermatofibrosarcoma protuberans arising in the site of a prior and current tattoo, and treated with Mohs micrographic surgery. We present findings of a case of a DFSP arising in a tattoo and a review of Medline literature on the association between tattoos and cutaneous malignancy, and treatment of DFSP with MMS. Review of the literature confirms multiple reports of DFSP arising in sites of local trauma, as well as malignancies arising in sites of tattoos. The recurrence rate for MMS treatment of DFSP (0-6.6%) was found to be significantly lower than that for patients treated with wide local excision (13% to 95%). DFSP should be considered in the differential diagnosis of neoplasms arising within areas of tattoos. Sites of local trauma and tattoos may show predilection for benign and malignant changes and should be evaluated during regular skin exams. Review of the literature confirms MMS is an ideal treatment modality for DFSP as the tumor often extends far beyond clinical margins.

  7. Avoidable cancers in the Nordic countries. Radiation

    DEFF Research Database (Denmark)

    Winther, J F; Ulbak, Kaare; Dreyer, L

    1997-01-01

    Exposure to solar and ionizing radiation increases the risk for cancer in humans. Some 5% of solar radiation is within the ultraviolet spectrum and may cause both malignant melanoma and non-melanocytic skin cancer; the latter is regarded as a benign disease and is accordingly not included in our...... estimation of avoidable cancers. Under the assumption that the rate of occurrence of malignant melanoma of the buttocks of both men and women and of the scalp of women would apply to all parts of the body in people completely unexposed to solar radiation, it was estimated that approximately 95% of all...... malignant melanomas arising in the Nordic populations around the year 2000 will be due to exposure to natural ultraviolet radiation, equivalent to an annual number of about 4700 cases, with 2100 in men and 2600 in women, or some 4% of all cancers notified. Exposure to ionizing radiation in the Nordic...

  8. Radiation Hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Castor, J I

    2003-10-16

    The discipline of radiation hydrodynamics is the branch of hydrodynamics in which the moving fluid absorbs and emits electromagnetic radiation, and in so doing modifies its dynamical behavior. That is, the net gain or loss of energy by parcels of the fluid material through absorption or emission of radiation are sufficient to change the pressure of the material, and therefore change its motion; alternatively, the net momentum exchange between radiation and matter may alter the motion of the matter directly. Ignoring the radiation contributions to energy and momentum will give a wrong prediction of the hydrodynamic motion when the correct description is radiation hydrodynamics. Of course, there are circumstances when a large quantity of radiation is present, yet can be ignored without causing the model to be in error. This happens when radiation from an exterior source streams through the problem, but the latter is so transparent that the energy and momentum coupling is negligible. Everything we say about radiation hydrodynamics applies equally well to neutrinos and photons (apart from the Einstein relations, specific to bosons), but in almost every area of astrophysics neutrino hydrodynamics is ignored, simply because the systems are exceedingly transparent to neutrinos, even though the energy flux in neutrinos may be substantial. Another place where we can do ''radiation hydrodynamics'' without using any sophisticated theory is deep within stars or other bodies, where the material is so opaque to the radiation that the mean free path of photons is entirely negligible compared with the size of the system, the distance over which any fluid quantity varies, and so on. In this case we can suppose that the radiation is in equilibrium with the matter locally, and its energy, pressure and momentum can be lumped in with those of the rest of the fluid. That is, it is no more necessary to distinguish photons from atoms, nuclei and electrons, than it is

  9. Radiation damage

    CERN Document Server

    Heijne, Erik H M; CERN. Geneva

    1998-01-01

    a) Radiation damage in organic materials. This series of lectures will give an overview of radiation effects on materials and components frequently used in accelerator engineering and experiments. Basic degradation phenomena will be presented for organic materials with comprehensive damage threshold doses for commonly used rubbers, thermoplastics, thermosets and composite materials. Some indications will be given for glass, scintillators and optical fibres. b) Radiation effects in semiconductor materials and devices. The major part of the time will be devoted to treat radiation effects in semiconductor sensors and the associated electronics, in particular displacement damage, interface and single event phenomena. Evaluation methods and practical aspects will be shown. Strategies will be developed for the survival of the materials under the expected environmental conditions of the LHC machine and detectors. I will describe profound revolution in our understanding of black holes and their relation to quantum me...

  10. Radiation Transport

    Energy Technology Data Exchange (ETDEWEB)

    Urbatsch, Todd James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-06-15

    We present an overview of radiation transport, covering terminology, blackbody raditation, opacities, Boltzmann transport theory, approximations to the transport equation. Next we introduce several transport methods. We present a section on Caseology, observing transport boundary layers. We briefly broach topics of software development, including verification and validation, and we close with a section on high energy-density experiments that highlight and support radiation transport.

  11. Radiation Protection

    Energy Technology Data Exchange (ETDEWEB)

    Loos, M

    2001-04-01

    Major achievements of SCK-CEN's Radiation Protection Department in 2000 are described. The main areas for R and D of the department remain neutron dosimetry and neutron activation analysis, safeguards information handling and non-destructive assay techniques. Further activities include low-level radioactivity measurements in environmental and biological samples and radiation protection research. Finally, achievements in decision strategy research and social sciences in nuclear research are reported.

  12. Brain radiation - discharge

    Science.gov (United States)

    Radiation - brain - discharge; Cancer-brain radiation; Lymphoma - brain radiation; Leukemia - brain radiation ... Decadron) while you are getting radiation to the brain. It may make you hungrier, cause leg swelling ...

  13. Radiation Therapy (For Parents)

    Science.gov (United States)

    ... Giving Teens a Voice in Health Care Decisions Radiation Therapy KidsHealth > For Parents > Radiation Therapy Print A ... have many questions and concerns about it. About Radiation Therapy In radiation therapy, high-energy radiation from ...

  14. Abdominal radiation - discharge

    Science.gov (United States)

    Radiation - abdomen - discharge; Cancer - abdominal radiation; Lymphoma - abdominal radiation ... When you have radiation treatment for cancer, your body goes through changes. About 2 weeks after radiation treatment starts, you might notice changes ...

  15. CONFERENCES AND SYMPOSIA: P N Lebedev Physical Institute RAS — 75 years(Joint session of the P N Lebedev Physical Institute Research Council and the Scientific session of the Physical Sciences Division of the Russian Academy of Sciences and the United Physical Society of the Russian Federation, 6 April 2009)

    Science.gov (United States)

    Mesyats, Gennadii A.; Bolotovskii, Boris M.; Kopaev, Yurii V.; Kardashev, Nikolai S.; Zatsepin, Georgii T.; Roganova, Tat'yana M.; Masalov, Anatolii V.; Gubin, Mikhail A.; Velichansky, Vladimir L.; Dagkesamanskii, Rustam D.

    2009-11-01

    A Joint session of the P N Lebedev Physical Institute Research Council of the Academy of Sciences and the Scientific session of the Physical Sciences Division of the Russian Academy of Sciences and the United Physical Society of the Russian Federation was convened on 6 April 2009 to mark the 75th anniversary of the P N Lebedev Physical Institute of the Academy of Sciences (FIAN). The following papers were read to the session: (1) Mesyats G A (P N Lebedev Physical Institute RAS) "75 years of the P N Lebedev Physical Institute RAS which traces back its origin to the Physics Room of Peter the Great's Kunstkamera created 225 years ago"; (2) Bolotovskii B M (Division of Theoretical Physics, P N Lebedev Physical Institute RAS) "Vavilov-Cherenkov radiation"; (3) Kopaev Yu V (Division of Solid State Physics, P N Lebedev Physical Institute RAS) "Toroidal states in crystals"; (4) Kardashev N S (Astro-Cosmic Center of the P N Lebedev Physical Institute RAS) "Science program of the Radioastron mission"; (5) Zatsepin G T (Nuclear Research Institute RAS), Roganova T M (M V Lomonosov Moscow State University, D V Skobeltsyn Nuclear Physics Research Institute) "Cosmic ray studies"; (6) Masalov A V (Optics Division, P N Lebedev Physical Institute RAS) "Spectroscopy: from atoms to cosmic objects"; (7) Gubin M A, Velichansky V L (Division of Quantum Radiophysics, P N Lebedev Physical Institute RAS) "Small-size optical frequency standards"; (8) Dagkesamanskii R D (Radioastronomical Observatory in Pushchino of the Astro-Cosmic Center of the P N Lebedev Physical Institute RAS) "Prospects for radioastronomical research in Pushchino". Articles written on the basis of these talks are printed in this special issue of Uspekhi Fizicheskikh Nauk (Usp. Fiz. Nauk 179 (11) 1145 - 1256 (2009) [English version: Phys. Usp. 52 (11) (2009] journal. • P N Lebedev Physical Institute RAS: past, present, and future, G A Mesyats Physics-Uspekhi, 2009, Volume 52, Number 11, Pages 1084-1097 • Vavilov-Cherenkov

  16. Myoepithelial carcinoma arising within an adenomyoepithelioma of the breast: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, You Yeon; Cho, Kyu Ran; Song, Sung Eun [Dept. of Radiology, Anam Hospital, Korea University College of Medicine, Seoul (Korea, Republic of); Seo, Bo Kyoung [Dept. of Radiology, Ansan Hospital, Korea University College of Medicine, Ansan (Korea, Republic of); Woo, Ok Hee [Dept. of Radiology, Guro Hospital, Korea University College of Medicine, Seoul (Korea, Republic of); Lee, Jeong Hyun [Dept. of Radiology, Anam Hospital, Korea University College of Medicine, Seoul (Korea, Republic of)

    2017-07-15

    Adenomyoepithelioma of the breast is a rare tumor. A myoepithelial carcinoma arising within an adenomyoepithelioma is even more unusual. There are a limited number of reports discussing myoepithelial carcinoma; most of them describe pathological findings, but not imaging findings. We present a case of a 55-year-old woman who had a screen-detected myoepithelial carcinoma arising within an adenomyoepithelioma in her right breast. Upon the completion of a mammography and sonography an oval shaped mass with an indistinct margin in the upper portion of the right breast had been seen. It as appeared to be a spiculated, irregular-shaped, peripheral-enhancing mass on an MRI. On sonography-guided biopsy, an epithelial-myothelial tumor was confirmed, and the possibility of myoepithelial carcinoma was suggested. Breast-conserving surgery with a sentinel lymph node dissection was performed, and a pathological examination revealed a myoepithelial carcinoma arising within an adenomyoepithelioma.

  17. Spindle cell variant of ameloblastic carcinoma arising from an unicystic amelobastoma: Report of a rare case

    Directory of Open Access Journals (Sweden)

    Venkatesh V Kamath

    2012-01-01

    Full Text Available Malignant transformation of ameloblastomas arising from an odontogenic cyst or de novo is well-recognized. Malignancies in ameloblastomas may involve metastasis or a local dysplastic change in the tissue. The latter are classified as ameloblastic carcinomas. A 75-year-old male presented with a mandibular cystic swelling, with no evidence of metastasis. Dysplastic ameloblastic cells with spindle-cell transformation were seen arising from a cystic lining with features of a unicystic ameloblastoma. Immunohistochemically the lesion stained positive with cytokeratin 8,19 and alpha smooth muscle actin, but was negative for vimentin. A diagnosis of spindle-cell ameloblastic carcinoma was made. Spindle-cell ameloblastic carcinomas are rare and this is the second case arising from a unicystic ameloblastoma reported in literature. The recognition of this transformation and inclusion of this entity in the classification of ameloblastic carcinomas is stressed.

  18. Mucinous adenocarcinoma arising at the anastomotic site after operation for hirschsprung's disease: case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyung Soo; Yoon, Kwon Ha [College of Medicine, Wonkwang Univ., Iksan (Korea, Republic of)

    2004-02-01

    To our knowledge, rectal cancer arising at the anastomotic site after surgery for Hirschsprung's disease has not been reported. We report a case of mucinous adenocarcinoma arising at the anastomotic site after Soave operation 26 years ago.

  19. Cystic papillary renal cell carcinoma arising from an involutional multicystic dysplastic kidney

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jeong Jae; Kim, Bong Soo; Huh, Jung Sik; Park, Kyung Gi; Choi, Guk Myung; Kim, Seung Hyoung; Maeng, Young Hee [Jeju National University School of Medicine, Jeju National University Hospital, Jeju (Korea, Republic of)

    2015-11-15

    Multicystic dysplastic kidney is a common cystic renal disease that often occurs in infancy. Recent studies demonstrate the possibility for spontaneous involution of a dysplastic kidney. In such cases, the prognosis is generally excellent and there is a very low incidence of complications. Complications associated with multicystic dysplastic kidney include pain, infection, hypertension, and neoplasia. Renal cell carcinomas are extremely rare in multicystic dysplastic kidneys. To our knowledge, no case report has described a radiologic finding of renal cell carcinoma arising from an involutional multicystic dysplastic kidney. We report a case of histopathologically validated cystic papillary renal cell carcinoma arising from an involutional multicystic dysplastic kidney and describe its sonographic and CT features.

  20. Solitary osteochondroma arising in lumbar spinous process: Case report

    Directory of Open Access Journals (Sweden)

    Khaled Hadhri

    2016-12-01

    Full Text Available Solitary osteochondromas rarely occur in the axial skeleton. Those tumors mostly arise on the posterior elements of the cervical column causing various symptoms especially when developing within the spinal canal. Exophytic lumbar variety is uncommon presenting with palpable mass or spinal deformity. We report a 20-year-old man presenting with a solid painless mass at the lower lumbar region. Radiological examinations revealed an exophytic lesion arising in the third lumbar spinous process appearing to be a solitary osteochondroma. The lesion was treated by en-bloc resection; histopathological examination confirmed the diagnosis of osteochondroma with no evidence of recurrence at the end of 2-year follow up.

  1. Aneurysmal Bone Cyst Arising from the First Rib: A Rare Cause of Thoracic Outlet Syndrome.

    Science.gov (United States)

    Medina, Manuel; Paul, Subroto

    2016-12-01

    Aneurysmal bone cyst is a rare benign cystic bone lesion with an incidence of only 0.14 per 100,000 individuals and most commonly affects the metaphyses of long bones, spine, and pelvis. We present a very rare case of a 17-year-old boy with a rapidly expanding aneurysmal bone cyst arising from the first rib, resulting in neurogenic thoracic outlet syndrome secondary to its compression of the brachial plexus. The patient's symptoms resolved after en bloc resection. To our knowledge there have been no other reports in the literature of thoracic outlet syndrome due to aneurysmal bone cyst arising from the first rib.

  2. Fibrosarcoma arising from gouty tophi: report of a unique case and review of literature.

    Science.gov (United States)

    Wang, Jian-Jun; Wang, Hai-Yan; Cheng, Kai; Wang, Xuan; Yu, Bo; Shi, Shan-Shan; Zhou, Xiao-Jun; Shi, Qun-Li

    2015-01-01

    Fibrosarcoma is a malignant mesenchymal tumor. To the author's best knowledge, no previous case of fibrosarcoma arising from gouty tophi has been reported. Here we reported the first case of fibrosarcoma arising from gouty tophi. A case of 58-year-old man was presented with a mass with ulcer and infection in the second joint of left middle finger for 2 months, with long standing gouty tophi. The tumor was biopsied and the biopsy showed complete excision of the tumor. With the pathological and immunohistochemical features considered, the diagnosis of fibrosarcoma associated with gouty tophi was made. The clinical findings, pathological characteristics and treatment were described.

  3. Obstructing in utero oropharyngeal mass: Case report of a lymphatic malformation arising within an oropharyngeal teratoma.

    Science.gov (United States)

    Wannemuehler, Todd J; Deig, Christopher R; Brown, Brandon P; Morgenstein, Stuart A

    2017-01-01

    An ex utero intrapartum treatment procedure was performed to deliver a fetus with a multiseptated, entirely cystic, 4.5 × 5.0 × 4.0-cm mass occupying the oropharynx and oral cavity with protrusion from the mouth. Surgical excision was performed, and final pathologic diagnosis revealed a lymphatic malformation arising within a cystic oropharyngeal teratoma. Lymphatic malformations are virtually indistinguishable radiologically from rare, purely cystic teratomata, and efforts have been made to distinguish between the two in utero because of differing available treatment modalities. This represents the first documented case in the literature of a lymphatic malformation arising from within an oropharyngeal teratoma.

  4. On time-dependent diffusion coefficients arising from stochastic processes with memory

    Science.gov (United States)

    Carpio-Bernido, M. Victoria; Barredo, Wilson I.; Bernido, Christopher C.

    2017-08-01

    Time-dependent diffusion coefficients arise from anomalous diffusion encountered in many physical systems such as protein transport in cells. We compare these coefficients with those arising from analysis of stochastic processes with memory that go beyond fractional Brownian motion. Facilitated by the Hida white noise functional integral approach, diffusion propagators or probability density functions (pdf) are obtained and shown to be solutions of modified diffusion equations with time-dependent diffusion coefficients. This should be useful in the study of complex transport processes.

  5. Adenocarcinomas arising from primary retroperitoneal mature teratomas: CT and MR imaging

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Li-Jen; Wong, Yon-Cheong [Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Taipei (Taiwan); Chu, Sheng-Hsien [Department of Urology, Chang Gung Memorial Hospital, Taipei (Taiwan); Ng, Kwai-Fong [Department of Pathology, Chang Gung Memorial Hospital, Taipei (Taiwan)

    2002-06-01

    An adenocarcinoma arising from mature teratoma is one form of teratoma with malignant transformation. It is extremely rare but highly malignant. The authors report two patients with adenocarcinomas arising from primary retroperitoneal teratomas. The CT and MRI findings of the tumors are presented with emphasis on imaging features implying the presence of malignant transformation and differing from those of pure benign mature teratoma. Correct diagnosis of the presence of malignant transformation from a benign mature teratoma can be made as early as possible by awareness of the imaging features. (orig.)

  6. Radiation myelopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sutherland, I.A.; Myers, S.J.

    1976-02-01

    Myelopathy secondary to radiation is a relatively uncommon entity which was reported initially in 1941 by Ahlbom. From a total of 65 patients who were seen in our spinal injury clinic during the past four years, three patients have received a diagnosis of radiation myelopathy. This is 4.6 percent of the total number. The case histories of two patients with radiation myelopathy are presented. The clinical and pathologic features are discussed. Since the three patients with this diagnosis whose cases are followed in the clinic are still alive, the second case that is reported is taken from the files of the pathology department so that autopsy and histologic data also can be presented.

  7. Directional radiation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Dowell, Jonathan L.

    2017-09-12

    Directional radiation detectors and systems, methods, and computer-readable media for using directional radiation detectors to locate a radiation source are provided herein. A directional radiation detector includes a radiation sensor. A radiation attenuator partially surrounds the radiation sensor and defines an aperture through which incident radiation is received by the radiation sensor. The aperture is positioned such that when incident radiation is received directly through the aperture and by the radiation sensor, a source of the incident radiation is located within a solid angle defined by the aperture. The radiation sensor senses at least one of alpha particles, beta particles, gamma particles, or neutrons.

  8. Toward an Improved Representation of Middle Atmospheric Dynamics Thanks to the ARISE Project

    NARCIS (Netherlands)

    Blanc, E; Ceranna, L.; Hauchecorne, A; Charlton-Perez, A; Marchetti, E.; Evers, L.G.; Kvaerna, T; Lastovicka, J.; Eliasson, L.; Crosby, N. B.; Blanc-Benon, P.; le Pichon, A; Brachet, N; Pilger, C; Keckhut, P; Assink, J. D.; Smets, P.S.M.; Lee, C. F.; Kero, J.; Sindelarova, T.; Kämpfer, N.; Rufenacht, R; Farges, T.; Millet, C.; Näsholm, S. P.; Gibbons, S. J.; Espy, P. J.; Hibbins, R. E.; Heinrich, P; Ripepe, M; Khaykin, S.; Mze, N.; Chum, J.

    2017-01-01

    This paper reviews recent progress toward understanding the dynamics of the middle atmosphere in the framework of the Atmospheric Dynamics Research InfraStructure in Europe (ARISE) initiative. The middle atmosphere, integrating the stratosphere and mesosphere, is a crucial region which influences

  9. Paneth cells in the developing gut : when do they arise and when are they immune competent?

    NARCIS (Netherlands)

    Heida, Fardou H.; Beyduz, Gaia; Bulthuis, Marian L. C.; Kooi, Elisabeth M. W.; Bos, Arend F.; Timmer, Albertus; Hulscher, Jan B. F.

    Background: Little is known about the perinatal development of Paneth cells (PCs) during gestation and the relation with necrotizing enterocolitis (NEC). We aimed to investigate when PCs arise and when they become immune competent during gestation. Methods: We included 57 samples of ileum tissue of

  10. A comparative study of iterative solutions to linear systems arising in quantum mechanics

    NARCIS (Netherlands)

    Jing, Yan-Fei; Huang, Ting-Zhu; Duan, Yong; Carpentieri, Bruno

    2010-01-01

    This study is mainly focused on iterative solutions with simple diagonal preconditioning to two complex-valued nonsymmetric systems of linear equations arising from a computational chemistry model problem proposed by Sherry Li of NERSC. Numerical experiments show the feasibility of iterative methods

  11. Saliva DHEAS Changes in Patients Suffering from Psychopathological Disorders Arising from Bullying at Work

    Science.gov (United States)

    Lac, Gerard; Dutheil, Frederic; Brousse, Georges; Triboulet-Kelly, Celine; Chamoux, Alain

    2012-01-01

    Background: Psychological disorders arising from bullying at work (BW) are common. The relationship between these disorders and putative markers is not well established. Aims: To measure saliva dehydroepiandrosterone sulphate (DHEAS) and saliva cortisol as putative markers in individuals suffering from BW. Methods: Forty one subjects suffering…

  12. Single string planning problem arising in liner shipping industries: A heuristic approach

    DEFF Research Database (Denmark)

    Gelareh, Shahin; Neamatian Monemi, Rahimeh; Mahey, Philippe

    2013-01-01

    We propose an efficient heuristic approach for solving instances of the Single String Planning Problem (SSPP) arising in the liner shipping industry. In the SSPP a Liner Service Provider (LSP) only revises one of its many operational strings, and it is assumed that the other strings are unchangea...

  13. Multicentric extra-abdominal desmoid tumors arising in bilateral lower limbs

    Directory of Open Access Journals (Sweden)

    Nobuhiro Fukushima

    2010-03-01

    Full Text Available Extra-abdominal desmoid tumors preferentially affect the shoulders, arms, backs, buttocks, and thighs of young adults. Multicentric occurrence is rather rare but seems to be another distinctive feature of extra-abdominal desmoid tumors. In this article we report a rare case of multicentric extra-abdominal desmoid tumors arising in bilateral lower limbs.

  14. Dynamics at infinity and a Hopf bifurcation arising in a quadratic ...

    Indian Academy of Sciences (India)

    Zhen Wang

    2017-12-27

    Dec 27, 2017 ... Dynamics at infinity and a Hopf bifurcation arising in a quadratic system with ... quadratic autonomous system, we raise the question: does there ..... 3200. + i. 41. 3200. , N22 = −. 23. 3200. − i. 41. 3200. ,. N12 = −. 41. 800 . The dynamics on the centre manifold is then governed by the equation. ˙w = 1. 2 iw +.

  15. Modification of the Absorption Edge of GaAs Arising from Hot-Electron Effects

    DEFF Research Database (Denmark)

    McGroddy, J. C.; Christensen, Ove

    1973-01-01

    We have observed a large enhancement of the electric-field-induced optical absorption arising from hot-electron effects in n-type GaAs at 77 K. The magnitude and field dependence of the enhancement can be approximately accounted for by a theory attributing the effect to broadening of the final...

  16. Where Cognitive Conflict Arises from?: The Structure of Creating Cognitive Conflict

    Science.gov (United States)

    Lee, Gyoungho; Yi, Jinseog

    2013-01-01

    In this study, our basic contention was that it is essential for researchers to answer the question, "Where does cognitive conflict really arise from?" with more precision than has heretofore been attempted. First, we examined how the term "cognitive conflict" has been treated in the existing literature and try to pinpoint some difficulties,…

  17. Aberrant ovarian artery arising from the common Iliac artery: Case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Won Kyung [Dept. of Radiology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon (Korea, Republic of); Yang, Seung Boo; Lee, Jae Myeong [Dept. of Radiology, Soonchunhyang University Gumi Hospital, Soonchunhyang University College of Medicine, Gumi (Korea, Republic of); Goo, Dong Erk; Kim, Yong Jae; Chang, Yun Woo [Dept. of Radiology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul (Korea, Republic of)

    2013-01-15

    A 46-year-old Vietnamese woman received embolization therapy in order to control postpartum hemorrhage. Angiography revealed an aberrant ovarian artery arising from the right common iliac artery. Superselective catheterization and subsequent embolization of the aberrant ovarian artery and bilateral uterine arteries were performed. Precise knowledge of the anatomic variations of the ovarian artery is important for successful embolization.

  18. On series involving zeros of trascendental functions arising from Volterra integral equations

    Directory of Open Access Journals (Sweden)

    Pietro Cerone

    2001-05-01

    Full Text Available Series arising from Volterra integral equations of the second kind are summed. The series involve inverse powers of roots of the characteristic equation. It is shown how previous similar series obtained from differential-difference equations are particular cases of the present development. A number of novel and interesting results are obtained. The techniques are demonstrated through illustrative examples.

  19. Exploring Ethical Dilemmas for Principals Arising from Role Conflict with School Counsellors

    Science.gov (United States)

    Kimber, Megan; Campbell, Marilyn

    2014-01-01

    Acting in the best interests of students is central to the moral and ethical work of schools. Yet tensions can arise between principals and school counsellors as they work from at times opposing professional paradigms. In this article we report on principals' and counsellors' responses to scenarios covering confidentiality and the law,…

  20. Monotonicity of a Key Function Arised in Studies of Nematic Liquid Crystal Polymers

    Directory of Open Access Journals (Sweden)

    Hongyun Wang

    2007-01-01

    Full Text Available We revisit a key function arised in studies of nematic liquid crystal polymers. Previously, it was conjectured that the function is strictly decreasing and the conjecture was numerically confirmed. Here we prove the conjecture analytically. More specifically, we write the derivative of the function into two parts and prove that each part is strictly negative.

  1. Conservation laws arising in the study of forward-forward Mean-Field Games

    KAUST Repository

    Gomes, Diogo A.

    2017-04-24

    We consider forward-forward Mean Field Game (MFG) models that arise in numerical approximations of stationary MFGs. First, we establish a link between these models and a class of hyperbolic conservation laws as well as certain nonlinear wave equations. Second, we investigate existence and long-time behavior of solutions for such models.

  2. An analysis of the perceived difficulties arising during the process of integrating management systems

    Directory of Open Access Journals (Sweden)

    Jesus Abad

    2016-09-01

    Originality/value: Most research emphasises the benefits of integrated management systems. By analysing the difficulties that arise during the integration process, this study contributes to fill a gap in the literature on the problems associated with processes of organisational change, in our case the integration of management systems.

  3. Selective Short-Term Memory Deficits Arise from Impaired Domain-General Semantic Control Mechanisms

    Science.gov (United States)

    Hoffman, Paul; Jefferies, Elizabeth; Ehsan, Sheeba; Hopper, Samantha; Lambon Ralph, Matthew A.

    2009-01-01

    Semantic short-term memory (STM) patients have a reduced ability to retain semantic information over brief delays but perform well on other semantic tasks; this pattern suggests damage to a dedicated buffer for semantic information. Alternatively, these difficulties may arise from mild disruption to domain-general semantic processes that have…

  4. Chest wall secondary chondrosarcoma arising from enchondroma in a young Asian female

    Directory of Open Access Journals (Sweden)

    Chih Chiang Nieh

    2014-01-01

    CONCLUSION: Secondary chondrosarcoma in a young Asian female arising from a benign solitary enchondroma in the absence of multiple enchondromatosis, such as Ollier disease or Maffucci syndrome, is extremely rare. Regular follow up including physical assessment and radiological imaging can result in earlier detection of malignant transformation obviating the need for aggressive surgical treatment involving multiple rib resections.

  5. An adaptive variable neighborhood search algorithm for a vehicle routing problem arising in small package shipping

    NARCIS (Netherlands)

    Stenger, Andreas; Vigo, Daniele; Enz, Steffen; Schwind, Michael

    2013-01-01

    In this paper, we investigate a routing problem arising in the last-mile delivery of small packages. The problem, called Multi-Depot Vehicle Routing Problem with Private fleet and Common carriers (MDVRPPC), is an extension of the Multi-Depot Vehicle Routing Problem (MDVRP) where customers can either

  6. Epithelioid sarcoma and squamous cell carcinoma arising in a burn scar

    Directory of Open Access Journals (Sweden)

    Kusum D Jashnani

    2011-01-01

    Full Text Available Development of a malignant tumor is a well known complication of a chronic burn scar. Most of these tumors are squamous cell carcinomas and only 28 cases of burn scar sarcomas have been reported in literature. We report the first occurrence of the combination of squamous cell carcinoma and epithelioid sarcoma arising in a burn scar.

  7. Flow features that arise due to the interaction of a plane shock wave with concave profiles

    CSIR Research Space (South Africa)

    MacLucas, David A

    2012-10-01

    Full Text Available The focus of the author's thesis was the aerodynamic flow field that develops as a result of the interaction of a moving plane shock wave with concave profiles. In this presentation, he discusses some of the interesting flow phenomena that arise...

  8. SOME PECULIARITIES ARISING IN THE STUDY OF NONLINEAR REGRESSION USING EXCEL AND OTHER PROGRAMS

    Directory of Open Access Journals (Sweden)

    Irina Vladlenovna Orlova

    2014-01-01

    Full Text Available The article considers the methodological and algorithmic features arising in modeling economic processes with the help of nonlinear regression models. Questions related to different approaches to estimation of nonlinear regression parameters are discussed in the article. Recommendations to build better models of non-linear regression are made.

  9. Ectopic breasts: familial functional axillary breasts and breast cancer arising in an axillary breast.

    Science.gov (United States)

    Osswald, Sandra S; Osswald, Michael B; Elston, Dirk M

    2011-06-01

    Supernumerary breasts and nipples are not uncommon and have familial and syndrome associations. Although usually of only cosmetic concern, hormonal changes and inflammatory or neoplastic conditions that affect primary breast tissue also may occur in areas of ectopic breast tissue. We describe cases of familial functional axillary breasts and primary carcinoma of the breast arising in ectopic axillary breast tissue.

  10. On Matrices Arising in the Finite Field Analogue of Euler’s Integral Transform

    Directory of Open Access Journals (Sweden)

    Michael Griffin

    2013-02-01

    Full Text Available In his 1984 Ph.D. thesis, J. Greene defined an analogue of the Euler integral transform for finite field hypergeometric series. Here we consider a special family of matrices which arise naturally in the study of this transform and prove a conjecture of Ono about the decomposition of certain finite field hypergeometric functions into functions of lower dimension.

  11. Land-use change arising from rural land exchange : an agent-based simulation model

    NARCIS (Netherlands)

    Bakker, Martha M.; Alam, Shah Jamal; van Dijk, Jerry; Rounsevell, Mark D. A.

    Land exchange can be a major factor driving land-use change in regions with high pressure on land, but is generally not incorporated in land-use change models. Here we present an agent-based model to simulate land-use change arising from land exchange between multiple agent types representing

  12. Land-use change arising from rural land exchange: an agent-based simulation model

    NARCIS (Netherlands)

    Bakker, M.M.; Alam, S.J.; Dijk, van J.; Rounsevell, M.D.A.

    2015-01-01

    Land exchange can be a major factor driving land-use change in regions with high pressure on land, but is generally not incorporated in land-use change models. Here we present an agent-based model to simulate land-use change arising from land exchange between multiple agent types representing

  13. Ionizing radiations in Italian health care structures

    Energy Technology Data Exchange (ETDEWEB)

    Fizzano, M.R.; Frusteri, L. [Technical Advisory Dept. for Risk Assessment and Prevention, Italian Workers Compensation Authority, Rome (Italy)

    2006-07-01

    The Council of the European Union has completely renewed the framework regarding radiation protection by adopting some directives: Directive 97/43 EURATOM lays down the general principles of the radiation protection of individuals undergoing exposure to ionising radiations related to medical exposures, as a supplement of Directive 96/29 EURATOM laying down the basic safety standards for the protection of the health of workers and the general public against the dangers arising from ionising radiations.The incorporation into Italian legislation of the European Community directives on the improvement of health and safety at work has promoted a vast effort in order to revise the surveillance approach in many facilities, including hospitals. In Italy, safety law is referred to every workplace; anyway the use of ionising radiations is ruled by specific laws. So in the health care structures it is necessary integrating both the laws and this process is often difficult to carry on. The Italian Legislative Decree 230/95, one the main laws that aim to protect workers against ionising radiations, introduced Directive 96/29/EURATOM. This Decree asks that a doctor and a technical expert analyse the workplace and classify area and workers in according to dose of ionising radiation established by law. The Italian Legislative Decree 626/94 asks that risk analysis in general is made by doctor and specialist in risk. So, in case of risk from ionising radiation, all these figures have to cooperate in order to make an evaluation risk document. (N.C.)

  14. Space Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Corliss, William R.

    1968-01-01

    This booklet discusses three kinds of space radiation, cosmic rays, Van Allen Belts, and solar plasma. Cosmic rays are penetrating particles that we cannot see, hear or feel, which come from distant stars. Van Allen Belts, named after their discoverer are great belts of protons and electrons that the earth has captured in its magnetic trap. Solar plasma is a gaseous, electrically neutral mixture of positive and negative ions that the sun spews out from convulsed regions on its surface.

  15. Radiation Engineering for Designers

    Science.gov (United States)

    Pellish, Jonathan A.

    2015-01-01

    This tutorial provides an overview of the natural space radiation environment, an introduction to radiation effect types, an overview of EEE parts selection, scrubbing, and radiation mitigation, and an introduction to radiation testing.

  16. Risk Factors: Radiation

    Science.gov (United States)

    Radiation of certain wavelengths, called ionizing radiation, has enough energy to damage DNA and cause cancer. Ionizing radiation includes radon, x-rays, gamma rays, and other forms of high-energy radiation.

  17. Acute Radiation Syndrome

    Science.gov (United States)

    ... Matters Information on Specific Types of Emergencies Acute Radiation Syndrome (ARS): A Fact Sheet for the Public ... is called the radiation dose. People exposed to radiation will get ARS only if: The radiation dose ...

  18. Chest radiation - discharge

    Science.gov (United States)

    Radiation - chest - discharge; Cancer - chest radiation; Lymphoma - chest radiation ... When you have radiation treatment for cancer, your body goes through changes. About 2 weeks after your first treatment: It may be hard ...

  19. Radiative entropy generation in a gray absorbing, emitting, and scattering planar medium at radiative equilibrium

    Science.gov (United States)

    Sadeghi, Pegah; Safavinejad, Ali

    2017-11-01

    Radiative entropy generation through a gray absorbing, emitting, and scattering planar medium at radiative equilibrium with diffuse-gray walls is investigated. The radiative transfer equation and radiative entropy generation equations are solved using discrete ordinates method. Components of the radiative entropy generation are considered for two different boundary conditions: two walls are at a prescribed temperature and mixed boundary conditions, which one wall is at a prescribed temperature and the other is at a prescribed heat flux. The effect of wall emissivities, optical thickness, single scattering albedo, and anisotropic-scattering factor on the entropy generation is attentively investigated. The results reveal that entropy generation in the system mainly arises from irreversible radiative transfer at wall with lower temperature. Total entropy generation rate for the system with prescribed temperature at walls remarkably increases as wall emissivity increases; conversely, for system with mixed boundary conditions, total entropy generation rate slightly decreases. Furthermore, as the optical thickness increases, total entropy generation rate remarkably decreases for the system with prescribed temperature at walls; nevertheless, for the system with mixed boundary conditions, total entropy generation rate increases. The variation of single scattering albedo does not considerably affect total entropy generation rate. This parametric analysis demonstrates that the optical thickness and wall emissivities have a significant effect on the entropy generation in the system at radiative equilibrium. Considering the parameters affecting radiative entropy generation significantly, provides an opportunity to optimally design or increase overall performance and efficiency by applying entropy minimization techniques for the systems at radiative equilibrium.

  20. Radiation Diffusion: An Overview of Physical and Numerical Concepts

    Energy Technology Data Exchange (ETDEWEB)

    Graziani, F R

    2005-01-14

    An overview of the physical and mathematical foundations of radiation transport is given. Emphasis is placed on how the diffusion approximation and its transport corrections arise. An overview of the numerical handling of radiation diffusion coupled to matter is also given. Discussions center on partial temperature and grey methods with comments concerning fully implicit methods. In addition finite difference, finite element and Pert representations of the div-grad operator is also discussed

  1. Intraosseous verrucous carcinoma arising from an infected dentigerous cyst—A case report

    Directory of Open Access Journals (Sweden)

    Chih-Yu Peng

    2015-08-01

    Full Text Available Intraosseous verrucous carcinoma (IOVC arising from an odontogenic cyst is extremely rare. We report a case of intraosseous verrucous carcinoma in a 74-year-old male who presented with a left mandibular swelling with recurrent pus discharge from gingiva of tooth #35. Panoramic radiography revealed an impacted tooth #34 and a large well-defined, radiolucent lesion surrounding the crown of tooth #34. The clinical diagnosis was an infected dentigerous cyst. Surgical excision of the cyst together with extraction of tooth #34 was performed. Histopathological examination showed proliferation of hyperparakeratotic stratified squamous cyst lining epithelium and down-growth of broad and bulbous epithelial ridges with pushing border invasion into the fibrous cystic wall. A verrucous carcinoma arising from an infected dentigerous cyst was diagnosed. There was no recurrence of the tumor 5 months after surgery.

  2. Automatic detection of EEG artefacts arising from head movements using EEG and gyroscope signals.

    Science.gov (United States)

    O'Regan, Simon; Faul, Stephen; Marnane, William

    2013-07-01

    Contamination of EEG signals by artefacts arising from head movements has been a serious obstacle in the deployment of automatic neurological event detection systems in ambulatory EEG. In this paper, we present work on categorizing these head-movement artefacts as one distinct class and on using support vector machines to automatically detect their presence. The use of additional physical signals in detecting head-movement artefacts is also investigated by means of support vector machines classifiers implemented with gyroscope waveforms. Finally, the combination of features extracted from EEG and gyroscope signals is explored in order to design an algorithm which incorporates both physical and physiological signals in accurately detecting artefacts arising from head-movements. Copyright © 2012 IPEM. Published by Elsevier Ltd. All rights reserved.

  3. The Settlement of Litigations Arising from the Interpretation and Enforcement of Administrative Contracts

    Directory of Open Access Journals (Sweden)

    Vasilica NEGRUŢ

    2015-03-01

    Full Text Available Regarded nowadays as an instrument of strategy implementation of government policy and establishment mechanism of public administration, the administrative contract raises many debates on its applicable regime, but also on the jurisdiction, to solve litigations arising from their interpretation and execution. In this paper we proposed, based on the analysis of the laws in force, doctrine, jurisprudence, and previous research results related to the subject, using the comparative method, to clarify the mentioned issues. The conclusions of this paper will strengthen the practice on the referral of courts competent to solve litigations arising from the implementation of the administrative contracts in the context where the administrative contract has profound implications in the administrative, economic and social field.

  4. The pressure equation arising in reservoir simulation. Mathematical properties, numerical methods and upscaling

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Bjoern Fredrik

    1997-12-31

    The main purpose of this thesis has been to analyse self-adjoint second order elliptic partial differential equations arising in reservoir simulation. It studies several mathematical and numerical problems for the pressure equation arising in models of fluid flow in porous media. The theoretical results obtained have been illustrated by a series of numerical experiments. The influence of large variations in the mobility tensor upon the solution of the pressure equation is analysed. The performance of numerical methods applied to such problems have been studied. A new upscaling technique for one-phase flow in heterogeneous reservoirs is developed. The stability of the solution of the pressure equation with respect to small perturbations of the mobility tensor is studied. The results are used to develop a new numerical method for a model of fully nonlinear water waves. 158 refs, 39 figs., 12 tabs.

  5. [Effects of cognitive load on responses arising from a sense of unwanted transparency].

    Science.gov (United States)

    Tabata, Naoya

    2008-10-01

    The sense of unwanted transparency refers to feelings that are experienced when someone appears to notice something during an interaction which one would rather not have them notice. This study investigated the effect of cognitive load on responses arising from the sense of unwanted transparency. First, the cognitive load required for intentional control of self-presentation and the sense of unwanted transparency were manipulated and nonverbal responses were measured. These activities with participants were videotaped. Then, observers were asked to rate videotapes of the participants for verbal content and their overall impressions. The results indicated that participants with a higher cognitive load displayed more nonverbal responses and less adequate verbal responses than participants with a lower cognitive load. Furthermore, the cognitive load affected the observers' impressions through responses arising from the sense of unwanted transparency.

  6. Anaplastic carcinoma arising in an ovarian mucinous cystadenocarcinoma in a 17-year-old female.

    Science.gov (United States)

    Vella, Joseph; Cracchiolo, Bernadette; Heller, Debra S

    2006-02-01

    Anaplastic carcinoma arising within a mucinous ovarian neoplasm is rare, with only about 30 reported cases. Reported cases have given a broad age range, ranging from 17 to 72 years of age, but occurrence in adolescents is exceptional, with only a few cases reported. We report a case of anaplastic carcinoma arising in a mucinous cystadenocarcinoma in a 17-year-old female who presented with severe abdominal pain, an unusual symptom for an ovarian malignancy in the postmenopausal patient, but not in the adolescent. The patient had widespread metastases at the time of presentation, consistent with the aggressive behavior of this neoplasm. This case illustrates that, although rare, epithelial ovarian malignancy is in the differential diagnosis of abdominal pain in an adolescent.

  7. Malignant mixed mullerian tumor arising from the uterine cervix: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Jong Joon; Shim, Jae Chan; Lee, Kyoung Eun; Lee, Ghi Jai; Kim, Ho Kyun; Suh, Jung Ho; Lee, Hye Kyung [Seoul Paik Hospital/Inje Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-10-15

    Malignant mixed mullerian tumors (MMMTs) are a rare uterine tumor and contribute to approximately 1-3% of all corpus malignant tumors. MMMTs are usually in the uterine corpus, but can also arise from the uterine cervix, vagina, ovaries and fallofian tubes. MMMTs of the uterine cervix are extremely rare. MMMTs are highly malignant and tend to maintain a rapid growth and exhibit a high rate of recurrence. Therefore, the prognosis of patients diagnosed with these types of tumors is extremely poor. We report a rare case of a malignant mixed mullerian tumor arising from the uterine cervix and introduce CT and MRI findings. CT and magnetic resonance findings of the uterine cervical MMMT in our case show highly aggressive features, such as parametrial involvement, pelvic and paraaortic lymphadenopathy, and distant metastasis and high enhancement.

  8. On the relationship of steady states of continuous and discrete models arising from biology.

    Science.gov (United States)

    Veliz-Cuba, Alan; Arthur, Joseph; Hochstetler, Laura; Klomps, Victoria; Korpi, Erikka

    2012-12-01

    For many biological systems that have been modeled using continuous and discrete models, it has been shown that such models have similar dynamical properties. In this paper, we prove that this happens in more general cases. We show that under some conditions there is a bijection between the steady states of continuous and discrete models arising from biological systems. Our results also provide a novel method to analyze certain classes of nonlinear models using discrete mathematics.

  9. Sustainable and responsible preventive medicine: Conceptualising ethical dilemmas arising from clinical implementation of advancing medical technology

    OpenAIRE

    Getz, Linn

    2006-01-01

    Background and setting Health care has become one of the most expansive activities in contemporary societies, and technology is one of its most influential factors. The modern medical-technological enterprise is however facing unprecedented practical, ethical and epistemic challenges. This thesis arises from a well-founded concern that medicine in general, and individually targeted preventive medicine in particular, may be about to become technified and dehumanised to an extent where its inte...

  10. An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota

    OpenAIRE

    Buntinx-Krieg, Talayesa; Ouyang, Jie; Cartwright, Mont

    2016-01-01

    Melanomas arising from orbital melanocytic proliferations are exceedingly rare. Many questions remain regarding their development and malignant transformation. We report on a 45-year-old Caucasian woman with a nevus of Ota that presented with visual disturbances involving her right eye and was found to have a biopsy-proven cellular blue nevus in the orbital space. Five years later, she presented with proptosis and worsening symptoms. Biopsy at that time showed a cellular blue nevus with areas...

  11. An unprecedented alpha-olefin distribution arising from a homogeneous ethylene oligomerization catalyst.

    Science.gov (United States)

    Tomov, Atanas K; Chirinos, Juan J; Long, Richard J; Gibson, Vernon C; Elsegood, Mark R J

    2006-06-21

    Treatment of the bis(benzimidazolyl)amine chromium complex 2 with ethylene in the presence of MAO affords an exceptionally active oligomerization catalyst and an unprecedented distribution of 1-olefin products in which the C4n series is much more abundant than the C4n+2 series. Deuterium labeling studies are consistent with a metallacyclic chain growth mechanism in which the unusual product distribution arises from the interplay of two sites.

  12. Squamous cell carcinoma arising in mature cystic teratoma with sigmoid invasion

    Directory of Open Access Journals (Sweden)

    Pooja Srivastava

    2015-01-01

    Full Text Available Malignant transformation in a mature cystic teratoma (MCT is rare occurring in 1.8% out of 8000 cases of MCT. The most common histological types are squamous cell carcinoma (SCC followed by adenocarcinoma and melanoma. Clinically, these tumors are usually asymptomatic but may be discovered accidentally during gynecologic examination due to mass effect. We present cytology and histology correlation of a rare case of SCC arising in a dermoid cyst with metastasis to sigmoid.

  13. Analysis of low energy electron emission arising during slow multicharged ion-surface interactions

    Energy Technology Data Exchange (ETDEWEB)

    Emmichoven, P.A.Z.v. (Oak Ridge National Laboratory, Oak Ridge, TN 37831-6372 (United States) Joint Institute for Heavy Ion Research, Holified Heavy Ion Research Facility, Oak Ridge, TN 37831-6734 (United States)); Havener, C.C. (Oak Ridge National Laboratory, Oak Ridge, TN 37831-6372 (United States)); Hughes, I.G. (Oak Ridge National Laboratory, Oak Ridge, TN 37831-6372 (United States) Joint Institute for Heavy Ion Research, Holifield Heavy Ion Research Facility, Oak Ridge, TN 37831-6374 (United States)); Zehner, D.M.; Meyer, F.W. (Oak Ridge National Laboratory, Oak Ridge, TN 37831-6732 (United States))

    1993-06-05

    We have undertaken a search for low energy electrons expected to arise in low energy multicharged ion-surface interactions when electrons captured into Rydberg levels of the projectile are promoted to the continuum as the projectile impacts the surface. Measurements are presented for 30--100 keV N[sup 2+] -N[sup 6+] ions incident at 20[degree] with the surface on Cu(001) and Au(011) single crystals, for a series of observation angles.

  14. Analysis of low energy electron emission arising during slow multicharged ion-surface interactions

    Energy Technology Data Exchange (ETDEWEB)

    Zeijlmans van Emmichoven, P.A.; Hughes, I.G. (Oak Ridge National Lab., TN (United States) Joint Institute for Heavy Ion Research, Holifield Heavy Ion Research Facility, Oak Ridge, TN (United States)); Havener, C.C.; Zehner, D.M.; Meyer, F.W. (Oak Ridge National Lab., TN (United States))

    1992-01-01

    We have undertaken a search for low energy electrons expected to arise in low energy multicharged ion-surface interactions when electrons captured into Rydberg levels of the projectile are promoted to the continuum as the projectile impacts the surface. Measurements are presented for 30--100 keV N{sup 2+} -- N{sup 6+} ions incident at 20{sup o} with the surface on Cu(001) and Au(0ll) single crystals, for a series of observation angles.

  15. Filiform serrated adenomatous polyposis arising in a diverted rectum of an inflammatory bowel disease patient

    DEFF Research Database (Denmark)

    Klarskov, Louise; Mogensen, Anne Mellon; Jespersen, Niels

    2011-01-01

    in the inflamed rectum stump. The malignant growth was surrounded by a filiform polyposis, grossly considered as pseudopolyps. The histology disclosed, however, a morphology corresponding to the recently described filiform subset of serrated adenoma (FSA). The clustering of the FSA amounted to a filiform serrated...... lesions of colorectal carcinoma arising in a chronically inflamed bowel as opposed to the generally more monotonous appearance of adenomas in a sporadic context....

  16. Highway filter drain waste arisings: a challenge for urban source control management?

    Science.gov (United States)

    Ellis, J B; Rowlands, E G

    2007-01-01

    Essential maintenance activities on highway BMP drainage controls involve refurbishment of filter (French) drains which can generate substantial amounts of "controlled waste". An innovative procedure for their re-instatement is described which offers a more sustainable option for filter drain/trench management. The quality classification of these waste arisings is problematical and it is difficult to reliably identify the risks posed by such materials and the most effective forms of management and disposal options.

  17. MR imaging findings of extraovarian endocervical mucinous borderline tumors arising from pelvic endometriosis

    Energy Technology Data Exchange (ETDEWEB)

    Yeo, Dong Myung; Rha, Sung Eun; Byun, Jae Young; Lee, Ahwon; Kim, Mee Ran [Seoul St. Mary' s Hospital, The Catholic University of Korea, Seoul (Korea, Republic of)

    2013-12-15

    We report MR imaging findings of a rare case of endocervical mucinous borderline tumor (MBT) involving the cul-de-sac and left fallopian tube arising from extensive pelvic endometriosis with pathologic correlation in a 35-year-old woman presented with vague pelvic pain. Endocervical MBT is a type of endometriosis-associated carcinoma. Imaging findings of endocervical MBT are unilocular or oligolocular cystic lesions with enhancing mural nodules, which are different from those of the more common intestinal type MBT.

  18. Cellular neurothekeomas arising on a café-au-lait macule.

    Science.gov (United States)

    Hernández-Martín, Angela; Colmenero, Isabel; Torrelo, Antonio

    2011-01-01

    Neurothekeoma is a tumor probably derived from the nerve sheath, which usually appears during the first 2 decades of life as a solitary papule or nodule; multiple neurothekeomas are very unusual. We present a case of multiple cellular neurothekeomas arising on a café-au-lait macule in a child, a situation that has not been reported to our knowledge. © 2011 Wiley Periodicals, Inc.

  19. Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence.

    Science.gov (United States)

    Sancheti, Sankalp M; Sawaimoon, Satyakam K; Ahmed, Rosina

    2015-01-01

    Primary malignant phyllodes tumor of the breast accounts for 0.3-1% of all the tumors of breast and only a couple of cases of pleomorphic liposarcoma (PL) arising in a malignant phyllodes (MP) tumor have been reported. A thorough sampling is most essential in phyllodes tumor, not only to detect high grade component of the neoplasm but also to diagnose heterologous elements in the same lesion elsewhere, as it may affect the prognosis adversely and may have a greater metastatic potential.

  20. Lipoma arborescens arising in the extra-articular bursa of the knee joint

    Science.gov (United States)

    Minami, Shinji; Miyake, Yusuke; Kinoshita, Hirofumi

    2016-01-01

    Lipoma arborescens arising in the extra-articular bursa of the knee joint is extremely rare. We describe an 11-year-old boy who complained of a gradual swelling mass of the lateral knee joint. Magnetic resonance imaging (MRI) showed a high signal intensity tumor on T1- and T2-weighted images with a thickened septa and nodular lesion that showed low signal intensity. The radiologist suggested the possible differential diagnosis of well-differentiated liposarcoma. At operation, the tumor was found under the iliotibial tract and was not in contact with the knee joint. Histopathologically, this lesion was diagnosed as lipoma arborescens arising in the extra-articular bursa of the knee joint. On MRI, the appearance of lipoma arborescens arising in the extra-articular bursa of the knee joint differed from that of conventional intra-articular lipoma arborescens. In this report, we describe a case of extra-articular lipoma arborescens of the knee joint bursa and discuss the diagnosis and etiology. PMID:27382924

  1. Clinical efficacy of stereotactic ablative radiotherapy for lung metastases arising from colorectal cancer.

    Science.gov (United States)

    Jung, Jinhong; Song, Si Yeol; Kim, Jong Hoon; Yu, Chang Sik; Kim, Jin Cheon; Kim, Tae Won; Jeong, Seong-Yun; Kim, Su Ssan; Choi, Eun Kyung

    2015-11-21

    Limited data describe the prognosis after stereotactic ablative radiotherapy for lung metastases arising from colorectal cancer. Thus, we evaluated treatment outcomes of stereotactic ablative radiotherapy for those patients. The study involved patients received stereotactic ablative radiotherapy for one to three lung metastases arising from colorectal cancer at a single institution. A total dose of 40-60 Gy (median, 48 Gy) in three or four fractions was prescribed. A total of 79 metastatic lung lesions from 50 patients who underwent curative resection for their primary colorectal cancer or salvage treatment at a recurrent site were included. The one- and three-year local control rates were 88.7 % and 70.6 %, respectively. The three-year overall survival and progression-free survival rates were 64.0 % and 24.0 %, respectively. Patients with tumor volume ≤1.5 mL had a significantly better overall survival rate than those with tumor volume >1.5 mL (68.0 % vs. 60.0 % at three-year, p = 0.02). Local control was associated with a trend towards better survival (p = 0.06). No pulmonary complications greater than grade 2 were observed. Stereotactic ablative radiotherapy is a competitive treatment modality for the management of lung metastases arising from colorectal cancer.

  2. Plasma radiation in tokamak disruption simulation experiments

    Energy Technology Data Exchange (ETDEWEB)

    Arkhipov, N.; Bakhtin, V.; Safronov, V.; Toporkov, D.; Vasenin, S.; Zhitlukhin, A. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Wuerz, H. [Forschungszentrum Karlsruhe (Germany)

    1995-12-31

    Plasma impact results in sudden evaporation of divertor plate material and produces a plasma cloud which acts as a protective shield. The incoming energy flux is absorbed in the plasma shield and is converted mainly into radiation. Thus the radiative characteristics of the target plasma determine the dissipation of the incoming energy and the heat load at the target. Radiation of target plasma is studied at the two plasma gun facility 2MK-200 at Troitsk. Space- and time-resolved spectroscopy and time-integrated space-resolved calorimetry are employed as diagnostics. Graphite and tungsten samples are exposed to deuterium plasma streams. It is found that the radiative characteristics depend strongly on the target material. Tungsten plasma arises within 1 {micro}s close to the surface and shows continuum radiation only. Expansion of tungsten plasma is restricted. For a graphite target the plasma shield is a mixture of carbon and deuterium. It expands along the magnetic field lines with a velocity of v = (3--4) 10{sub 6} cm/s. The plasma shield is a two zone plasma with a hot low dense corona and a cold dense layer close to the target. The plasma corona emits intense soft x-ray (SXR) line radiation in the frequency range from 300--380 eV mainly from CV ions. It acts as effective dissipation system and converts volumetrically the incoming energy flux into SXR radiation.

  3. Covariant anomalies and Hawking radiation from Kaluza–Klein AdS ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 80; Issue 2. Covariant anomalies and Hawking radiation from Kaluza–Klein AdS ... angular momentum and energy momentum tensor are derived here. Our results support the common view that Hawking radiation is the quantum effect arising at the event horizon.

  4. Radiation-induced vascular lesions of the skin: an overview

    NARCIS (Netherlands)

    Flucke, U.E.; Requena, L.; Mentzel, T.

    2013-01-01

    Radiation-induced cutaneous vascular neoplasms occur infrequently and comprise benign, so-called atypical vascular lesions (AVL) and angiosarcomas (AS), often being high-grade malignant tumors. Both arise most frequently within previously irradiated skin in breast-conserving-treated mammary cancer

  5. New materials for radiation hard semiconductor detectors

    CERN Document Server

    Sellin, P J; CERN. Geneva

    2006-01-01

    We present a review of the current status of research into new semiconductor materials for use as particle tracking detectors in very high radiation environments. This work is carried out within the framework of the CERN RD50 collaboration, which is investigating detector technologies suitable for operation at the proposed Super-LHC facility (SLHC). Tracking detectors operating at the SLHC in this environment will have to be capable of withstanding radiation levels arising from a luminosity of 1035 cm-2s-1 which will present severe challenges to current tracking detector technologies. The "new materials" activity within RD50 is investigating the performance of various semiconductor materials that potentially offer radiation hard alternatives to silicon devices. The main contenders in this study are silicon carbide, gallium nitride and amorphous silicon. In this paper we review the current status of these materials, in terms of material quality, commercial availability, charge transport properties, and radiati...

  6. Serous papillary adenocarcinoma probably arising from epithelial inclusions of the hepatic hilar lymph node.

    Science.gov (United States)

    Terada, Tadashi

    2012-07-01

    Only three cases of serous adenocarcinoma arising from Mullerian epithelial inclusions of the lymph node have been reported. Herein reported is a case of serous papillary adenocarcinoma arising probably from epithelial (Mullerian) inclusions of the hepatic hilar lymph node. A 73-year-old woman presented with peripheral neuropathy, which was thought to be a paraneoplastic syndrome associated with visceral malignancy. Total body examination, including X-P, US, CT, MRI, PET, and upper and lower gastrointestinal endoscopy was done. As the results, only lymph node swelling was detected in the hepatic hilus. Tumor was not identified in other sites. The physicians considered malignant lymphoma, and laparotomic excision of the hepatic hilar mass was performed. Cytological examination of abdominal cavity washing revealed no malignant cells. Grossly, the mass was firm and white and measured 4 × 5 × 5 cm. Microscopically, the mass showed carcinoma cells arranged in papillary and tubular patterns. The appearances strongly resembled serous papillary adenocarcinoma of the ovary. Lymph node structures were noted in some peripheral areas. No benign epithelial inclusions were recognized. Immunohistochemically, the carcinoma cells were positive for ER, PgR, CA125, WT1, p53. They were negative for TTF-1 and CDX-2. Because the positive ER, PgR, CA125, WT1, p53 and p16 are indicative of gynecologic malignancy, simple hysterectomy and bilateral salpingo-oophorectomy were performed, which showed no abnormalities. Cytological examination of abdominal cavity washing fluid revealed no malignant cells. The patient was treated by paclitaxel and carboplatin, and is now alive without metastasis 2 years after the first manifestation. The author reported a case of serous papillary adenocarcinoma arising probably from epithelial (Mullerian) inclusions of the hepatic hilar lymph node.

  7. Small cell carcinoma arising in Barrett's esophagus: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Markogiannakis Haridimos

    2008-01-01

    Full Text Available Abstract Introduction Gastrointestinal tract small cell carcinoma is an infrequent and aggressive neoplasm that represents 0.1–1% of gastrointestinal malignancies. Very few cases of small cell esophageal carcinoma arising in Barrett's esophagus have been reported in the literature. An extremely rare case of primary small cell carcinoma of the distal third of the esophagus arising from dysplastic Barrett's esophagus is herein presented. Case presentation A 62-year-old man with gastroesophageal reflux history presented with epigastric pain, epigastric fullness, dysphagia, anorexia, and weight loss. Esophagogastroscopy revealed an ulceroproliferative, intraluminar mass in the distal esophagus obstructing the esophageal lumen. Biopsy showed small cell esophageal carcinoma. Contrast-enhanced chest and abdominal computed tomography demonstrated a large tumor of the distal third of the esophagus without any lymphadenopathy or distant metastasis. Preoperative chemotherapy with cisplatine and etoposide for 3 months resulted in a significant reduction of the tumor. After en block esophagectomy with two field lymph node dissection, proximal gastrectomy, and cervical esophagogastric anastomosis, the patient was discharged on the 14th postoperative day. Histopathology revealed a primary small cell carcinoma of the distal third of the esophagus arising from dysplastic Barrett's esophagus. The patient received another 3 month course of postoperative chemotherapy with the same agents and remained free of disease at 12 month review. Conclusion Although small cell esophageal carcinoma is rare and its association with dysplastic Barrett's esophagus is extremely infrequent, the high carcinogenic risk of Barrett's epithelium should be kept in mind. Prognosis is quite unfavorable; a better prognosis might be possible with early diagnosis and treatment strategies incorporating chemotherapy along with oncological radical surgery and/or radiotherapy as part of a

  8. Toward an Improved Representation of Middle Atmospheric Dynamics Thanks to the ARISE Project

    Science.gov (United States)

    Blanc, E.; Ceranna, L.; Hauchecorne, A.; Charlton-Perez, A.; Marchetti, E.; Evers, L. G.; Kvaerna, T.; Lastovicka, J.; Eliasson, L.; Crosby, N. B.; Blanc-Benon, P.; Le Pichon, A.; Brachet, N.; Pilger, C.; Keckhut, P.; Assink, J. D.; Smets, P. S. M.; Lee, C. F.; Kero, J.; Sindelarova, T.; Kämpfer, N.; Rüfenacht, R.; Farges, T.; Millet, C.; Näsholm, S. P.; Gibbons, S. J.; Espy, P. J.; Hibbins, R. E.; Heinrich, P.; Ripepe, M.; Khaykin, S.; Mze, N.; Chum, J.

    2017-11-01

    This paper reviews recent progress toward understanding the dynamics of the middle atmosphere in the framework of the Atmospheric Dynamics Research InfraStructure in Europe (ARISE) initiative. The middle atmosphere, integrating the stratosphere and mesosphere, is a crucial region which influences tropospheric weather and climate. Enhancing the understanding of middle atmosphere dynamics requires improved measurement of the propagation and breaking of planetary and gravity waves originating in the lowest levels of the atmosphere. Inter-comparison studies have shown large discrepancies between observations and models, especially during unresolved disturbances such as sudden stratospheric warmings for which model accuracy is poorer due to a lack of observational constraints. Correctly predicting the variability of the middle atmosphere can lead to improvements in tropospheric weather forecasts on timescales of weeks to season. The ARISE project integrates different station networks providing observations from ground to the lower thermosphere, including the infrasound system developed for the Comprehensive Nuclear-Test-Ban Treaty verification, the Lidar Network for the Detection of Atmospheric Composition Change, complementary meteor radars, wind radiometers, ionospheric sounders and satellites. This paper presents several examples which show how multi-instrument observations can provide a better description of the vertical dynamics structure of the middle atmosphere, especially during large disturbances such as gravity waves activity and stratospheric warming events. The paper then demonstrates the interest of ARISE data in data assimilation for weather forecasting and re-analyzes the determination of dynamics evolution with climate change and the monitoring of atmospheric extreme events which have an atmospheric signature, such as thunderstorms or volcanic eruptions.

  9. A mild mutator phenotype arises in a mouse model for malignancies associated with neurofibromatosis type 1

    Energy Technology Data Exchange (ETDEWEB)

    Garza, Rene [Department of Cellular and Structural Biology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900 (United States); Hudson, Robert A. [Department of Cellular and Structural Biology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900 (United States); McMahan, C. Alex [Department of Pathology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900 (United States); Walter, Christi A. [Department of Cellular and Structural Biology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900 (United States); South Texas Veterans Healthcare System, San Antonio, TX 78229 (United States); Vogel, Kristine S. [Department of Cellular and Structural Biology, University of Texas, Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900 (United States)]. E-mail: vogelk@uthscsa.edu

    2007-02-03

    Defects in genes that control DNA repair, proliferation, and apoptosis can increase genomic instability, and thus promote malignant progression. Although most tumors that arise in humans with neurofibromatosis type 1 (NF1) are benign, these individuals are at increased risk for malignant peripheral nerve sheath tumors (MPNST). To characterize additional mutations required for the development of MPNST from benign plexiform neurofibromas, we generated a mouse model for these tumors by combining targeted null mutations in Nf1 and p53, in cis. CisNf1+/-; p53+/- mice spontaneously develop PNST, and these tumors exhibit loss-of-heterozygosity at both the Nf1 and p53 loci. Because p53 has well-characterized roles in the DNA damage response, DNA repair, and apoptosis, and because DNA repair genes have been proposed to act as modifiers in NF1, we used the cisNf1+/-; p53+/- mice to determine whether a mutator phenotype arises in NF1-associated malignancies. To quantitate spontaneous mutant frequencies (MF), we crossed the Big Blue mouse, which harbors a lacI transgene, to the cisNf1+/-; p53+/- mice, and isolated genomic DNA from both tumor and normal tissues in compound heterozygotes and wild-type siblings. Many of the PNST exhibited increased mutant frequencies (MF = 4.70) when compared to normal peripheral nerve and brain (MF = 2.09); mutations occurred throughout the entire lacI gene, and included base substitutions, insertions, and deletions. Moreover, the brains, spleens, and livers of these cisNf1+/-; p53+/- animals exhibited increased mutant frequencies when compared to tissues from wild-type littermates. We conclude that a mild mutator phenotype arises in the tumors and tissues of cisNf1+/-; p53+/- mice, and propose that genomic instability influences NF1 tumor progression and disease severity.

  10. Persistent dorsal ophthalmic artery arising from the internal carotid artery: Report of three cases

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Jae Hwan; Lee, Ghi Jai; Shim, Jae Chan; Lee, Kyoung Eun; Kim, Ho Kyun; Suh, Jung Ho [Dept. of Radiology, Seoul Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2016-12-15

    Normally, the ophthalmic artery (OA) arises from the supraclinoid segment of the internal carotid artery (ICA) and enters the orbit via the optic canal. A persistent dorsal OA is a rare variation that originates from the cavernous segment of the ICA and enters the orbit via the superior orbital fissure. To the best of our knowledge, persistent dorsal OA has not been described in the Korean literature. In this paper, we report three cases of persistent dorsal OA with review of the literature on embryogenesis and other origins of the OA.

  11. Assessment of two analytical approaches in some nonlinear problems arising in engineering sciences

    Energy Technology Data Exchange (ETDEWEB)

    Ganji, D.D. [Babol (Noushiravani) University of Technology, Department of Mechanical Engineering, P.O. Box 484, Babol (Iran, Islamic Republic of)], E-mail: ddg_davood@yahoo.com; Sadighi, A. [Babol (Noushiravani) University of Technology, Department of Mechanical Engineering, P.O. Box 484, Babol (Iran, Islamic Republic of)], E-mail: am_sadighi@yahoo.com; Khatami, I. [Babol (Noushiravani) University of Technology, Department of Mechanical Engineering, P.O. Box 484, Babol (Iran, Islamic Republic of)

    2008-06-09

    In this research, two powerful analytical methods are introduced to handle nonlinear good Boussinesq, heat transfer and coupled Burgers' equations. One is the homotopy-perturbation method (HPM) and the other is the variational iteration method (VIM). VIM is used to construct correction functionals using general Lagrange multipliers identified optimally via the variational theory. HPM converts a difficult problem into a simple one, which can be easily handled. The results attained in this paper confirm the idea that HPM and VIM are powerful mathematical tools and that they can be applied to a large class of linear and nonlinear problems arising in different fields of science and engineering.

  12. Assessment of two analytical approaches in some nonlinear problems arising in engineering sciences

    Science.gov (United States)

    Ganji, D. D.; Sadighi, A.; Khatami, I.

    2008-06-01

    In this research, two powerful analytical methods are introduced to handle nonlinear good Boussinesq, heat transfer and coupled Burgers' equations. One is the homotopy-perturbation method (HPM) and the other is the variational iteration method (VIM). VIM is used to construct correction functionals using general Lagrange multipliers identified optimally via the variational theory. HPM converts a difficult problem into a simple one, which can be easily handled. The results attained in this paper confirm the idea that HPM and VIM are powerful mathematical tools and that they can be applied to a large class of linear and nonlinear problems arising in different fields of science and engineering.

  13. Invasive Ductal Carcinoma Arising in Phyllodes Tumor With Isolated Tumor Cells in Sentinel Lymph Node

    Directory of Open Access Journals (Sweden)

    Ying-Ju Kuo

    2010-11-01

    Full Text Available Phyllodes tumor (PT consists of stroma of variable grading and benign ductal epithelium. Although exceptional, carcinomas that arise from the epithelium in PTs do exist, and seem to behave less aggressively than the usually encountered breast carcinoma. To the best of our knowledge, among the invasive carcinomas that have arisen in PTs, only 1 has been proved to have metastatic carcinoma in the lymph nodes. Here, we describe the youngest woman to have invasive ductal carcinoma that arose in a borderline PT, with isolated carcinoma cells in the sentinel lymph node. Whether such a combined lesion carries a more indolent course is also discussed.

  14. Left bronchial artery arising from a replaced left hepatic artery in a patient with massive hemoptysis

    Energy Technology Data Exchange (ETDEWEB)

    Khil, Eun Kyung; Lee, Jae Myung [Dept. of Radiology, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon (Korea, Republic of)

    2015-09-15

    A 70-year-old man with a 3-year history of bronchiectasis presented with massive hemoptysis that had lasted for 3 days. In our attempt to perform bronchial artery embolization, upper abdominal angiography was required to locate the left bronchial artery, which in this case was of anomalous origin, arising from a replaced left hepatic artery, which arose from the left gastric artery-a very unusual anatomical variant. We performed embolization with polyvinyl alcohol particles, and the patient's symptoms resolved completely, with no additional complications after conservative treatment.

  15. Variational Iteration Method for Nonlinear Singular Two-Point Boundary Value Problems Arising in Human Physiology

    Directory of Open Access Journals (Sweden)

    Marwan Abukhaled

    2013-01-01

    Full Text Available The variational iteration method is applied to solve a class of nonlinear singular boundary value problems that arise in physiology. The process of the method, which produces solutions in terms of convergent series, is explained. The Lagrange multipliers needed to construct the correctional functional are found in terms of the exponential integral and Whittaker functions. The method easily overcomes the obstacle of singularities. Examples will be presented to test the method and compare it to other existing methods in order to confirm fast convergence and significant accuracy.

  16. Anterior abdominal wall leiomyoma arising de novo in a fertile women: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Je Young; Woo, Ji Young; Hong, Hye Suk; Yang, Ik; Lee, Yul; Hwang, Ji Young; Kim, Han Myun; Shin, Mi Kyung [Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul (Korea, Republic of)

    2016-01-15

    Abdominal wall leiomyoma arising de novo is very rare, hence the reported imaging findings of this disease are also rare. We reported the case of a 33-year-old woman who presented with an abdominal wall mass without antecedent gynecological surgeries. The initial abdominal computed tomography (CT) showed thickening of the left rectus abdominis and the loss of intervening fat between the rectus abdominis and the lateral abdominal muscles. After 8 months, the follow-up contrast-enhanced CT and ultrasonography (US) showed a lentiform-shaped mass with isodensity to the adjacent muscles. The US-guided biopsy was consistent with leiomyoma.

  17. Kinetic study of coupled field-induced aggregation and sedimentation processes arising in magnetic fluids.

    Science.gov (United States)

    Martínez-Pedrero, F; El-Harrak, A; Fernández-Toledano, J C; Tirado-Miranda, M; Baudry, J; Schmitt, A; Bibette, J; Callejas-Fernández, J

    2008-07-01

    In this work, the kinetics of coupled aggregation and sedimentation processes arising in magnetic fluids has been studied. Aggregation was induced applying a constant uniaxial magnetic field. The time evolution of the cluster-size distribution and the weight-average chain length was monitored using optical microscopy and digital image analysis. The experimental results are compared with the corresponding solutions of Smoluchowski's equation. For this purpose, a recently proposed aggregation kernel was employed. When sedimentation effects are taken into account, the fits improve especially at long aggregation times.

  18. Magnetohydrodynamic perturbations arising in metallic conductors under the action of the discharge current

    Science.gov (United States)

    Surkaev, A. L.

    2015-07-01

    The presence of radial and axial mechanical perturbations in metallic conductors (cylinders and flat plates) arising under the action of a nanosecond discharge current are proved experimentally. The amplitude of the mechanical perturbations in solid-state conductors oscillates. The radial component of the mechanical perturbation should be considered as a reason for a magnetohydrodynamic instability with mode m = 0 and, accordingly, for the formation of strata at the electrical explosion of the conductor. Data for the electrical explosion of the metallic cylindrical conductor and flat metal sheet (foil) are presented.

  19. Myxofibrosarcoma: First report of myxofibrosarcoma of bone arising at a bone infarct.

    Science.gov (United States)

    Kayser, Dietrich; Walton, Zeke; Bruner, Evelyn; Chapin, Russell W

    2017-08-01

    Approximately 3300 new primary bone tumors will present to American physicians this year. This small but important group of malignancies has become more defined with developments in pathologic morphology, immunohistochemistry, and molecular studies. As tumor types are better partitioned, their specific characteristics are more readily observed. In this article we present the first reported case of a myxofibrosarcoma of bone developing within a bone infarct. With improved delineation of rarer tumor types, it is expected that additional cases of myxofibrosarcoma of bone will be recognized, potentially arising from a bone infarct. By framing the context, describing the case, and sharing pertinent figures, we hope to facilitate this recognition.

  20. Rapidly lethal metastatic melanoma arising from a large congenital melanocytic naevus

    OpenAIRE

    Wei, Christina Hsiao; Shoo, Brenda A.; Zedek, Daniel C.; Kashani-Sabet, Mohammed; Sagebiel, Richard W.; Leong, Stanley P L

    2009-01-01

    A case of fatal metastatic melanoma arising from a very large congenital melanocytic naevus (VLCMN) is reported. Large congenital naevi (LCMN) are naevi >20 cm in diameter. VLCMN is used in this report to mean an extensive LCMN involving a large percentage of the body, including smaller so-called satellite naevi. A 19-year-old man with a large congenital melanocytic naevus (LCMN) presented with a new nodule on the left chest wall, which was diagnosed as a thick melanoma with synchronous axill...

  1. Distribution-valued weak solutions to a parabolic problem arising in financial mathematics

    Directory of Open Access Journals (Sweden)

    Michael Eydenberg

    2009-07-01

    Full Text Available We study distribution-valued solutions to a parabolic problem that arises from a model of the Black-Scholes equation in option pricing. We give a minor generalization of known existence and uniqueness results for solutions in bounded domains $Omega subset mathbb{R}^{n+1}$ to give existence of solutions for certain classes of distributions $fin mathcal{D}'(Omega$. We also study growth conditions for smooth solutions of certain parabolic equations on $mathbb{R}^nimes (0,T$ that have initial values in the space of distributions.

  2. MR findings of squamous cell carcinoma arising from chronic osteomyelitis of the tibia: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Han, Dong Hwa; Lee, Ji Hae; Cho, Woo Ho; Kim, Jae Hyung; Jeong, Myeong Ja; Kim, Soung Hee; Kim, Ji Young; Kim, Soo Hyun; Kang, Mi Jin; Bae, Kyung Eun [Dept. of Radiology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul (Korea, Republic of)

    2016-05-15

    Malignant transformation is a rare and late complication of untreated chronic osteomyelitis. Known radiographic findings of the malignant transformation of chronic osteomyelitis are osteolytic or mixed sclerotic and osteolytic lesions with or without soft tissue mass. But its magnetic resonance (MR) imaging findings are rarely described in the literature. We experienced a case of an 82-year-old man diagnosed with squamous cell carcinoma arising from long standing chronic osteomyelitis of the tibia. Our case indicates that radiologists should consider the possibility of malignant transformation in patients with untreated chronic osteomyelitis, with enhancing soft tissue mass invading and extending through underlying bone cortex and medulla on MR imaging.

  3. The Genetic Counselor's Role in Managing Ethical Dilemmas Arising in the Laboratory Setting.

    Science.gov (United States)

    Balcom, Jessica R; Kotzer, Katrina E; Waltman, Lindsey A; Kemppainen, Jennifer L; Thomas, Brittany C

    2016-10-01

    Ethical dilemmas are encountered commonly in the setting of the clinical genetic testing laboratory due to the complexity of genetic testing and the number of relevant stakeholders involved in the genetic testing process. Based on their clinical training and role within the laboratory, genetic counselors are uniquely equipped to identify and facilitate management of ethical dilemmas. This paper reviews the historical context of ethical theory and its application to the field of genetic counseling. Theoretical and applied ethics are explored in the context of dilemmas arising in the laboratory setting, with a focus on the role of the laboratory genetic counselor in managing ethical dilemmas. Two illustrative case examples are provided.

  4. A non-local free boundary problem arising in a theory of financial bubbles

    OpenAIRE

    Berestycki, Henri; Monneau, Regis; Scheinkman, José A.

    2014-01-01

    We consider an evolution non-local free boundary problem that arises in the modelling of speculative bubbles. The solution of the model is the speculative component in the price of an asset. In the framework of viscosity solutions, we show the existence and uniqueness of the solution. We also show that the solution is convex in space, and establish several monotonicity properties of the solution and of the free boundary with respect to parameters of the problem. To study the free boundary, we...

  5. Land-use change arising from rural land exchange: an agent-based simulation model

    OpenAIRE

    Martha M. Bakker; Alam, Shah Jamal; van Dijk, Jerry; Rounsevell, Mark D A

    2015-01-01

    Land exchange can be a major factor driving land-use change in regions with high pressure on land, but is generally not incorporated in land-use change models. Here we present an agent-based model to simulate land-use change arising from land exchange between multiple agent types representing farmers, nature organizations, and estate owners. The RULEX model (Rural Land EXchange) was calibrated and applied to a 300 km(2) case study area in the east of the Netherlands. Decision rules about whic...

  6. Squamous Cell Carcinomas on Bilateral Feet Arising in Long-Standing Eczematous Lesions.

    Science.gov (United States)

    Yamase, Aya; Funasaka, Yoko; Ueno, Takashi; Ito, Michiko; Otsuka, Yohei; Kawana, Seiji; Saeki, Hidehisa

    2017-01-01

    We present a woman with squamous cell carcinomas on both feet in long-standing eczematous lesions. Histopathological examination of biopsies from the both feet revealed highly atypical cells invading the reticular layer of the dermis in the hyperkeratotic lesion and they were associated with surrounding dermatitis with spongiosis. Although the cause and etiology of eczema in our case is unclear, we speculate that the exceptionally long-lasting dermatitis might have induced double SCCs on bilateral feet with an unusual constitution. To the best of our knowledge, this is a first case of SCC on bilateral feet arising in long-standing eczematous lesions.

  7. Electromagnetic radiation due to nonlinear oscillations of a charged drop

    Science.gov (United States)

    Shiryaeva, S. O.; Grigor'ev, A. N.; Kolbneva, N. Yu.

    2016-03-01

    The nonlinear oscillations of a spherical charged drop are asymptotically analyzed under the conditions of a multimode initial deformation of its equilibrium shape. It is found that if the spectrum of initially excited modes contains two adjacent modes, the translation mode of oscillations is excited among others. In this case, the center of the drop's charge oscillates about the equilibrium position, generating a dipole electromagnetic radiation. It is shown that the intensity of this radiation is many orders of magnitude higher than the intensity of the drop's radiation, which arises in calculations of the first order of smallness and is related to the drop's charged surface oscillations.

  8. RADIATION COUNTER

    Science.gov (United States)

    Goldsworthy, W.W.

    1958-02-01

    This patent relates to a radiation counter, and more particularly, to a scintillation counter having high uniform sensitivity over a wide area and capable of measuring alpha, beta, and gamma contamination over wide energy ranges, for use in quickly checking the contami-nation of personnel. Several photomultiplier tubes are disposed in parallel relationship with a light tight housing behind a wall of scintillation material. Mounted within the housing with the photomultipliers are circuit means for producing an audible sound for each pulse detected, and a range selector developing a voltage proportional to the repetition rate of the detected pulses and automatically altering its time constant when the voltage reaches a predetermined value, so that manual range adjustment of associated metering means is not required.

  9. Radiation pneumonitis

    Energy Technology Data Exchange (ETDEWEB)

    Amla, T.R.; Chakravarti, R.N.; Lal, K.

    1975-07-01

    Adult healthy rhesus monkeys were exposed to a course of roentgen irradiation over the chest and back to produce pulmonary changes simulating human radiation pneumonitis. Macroscopic and morphologic changes included dense adhesions, pleural thickening and increased consistency of the lungs. Microscopically the early reaction was characterized by dilatation of pulmonary vessels, microhaemorrhages, collapse of alveoli, permeation of the interstitial tissue with a fibrinous fluid and cells. In the late stage the fibrinous interstitial matrix was replaced by hyaline eosinophilic mass, fragmentation and dissolution of the elastic tissue and thickening of the alveolar walls. The cell population in the interstitial tissue showed decline and at places radiolytic effect. There was peribronchial and perivascular fibrosis and hyalinization and pulmonary arteries revealed marked degree of arteriosclerosis. The present study opens a new field for experimental research on the development of pulmonary hypertension as a post-irradiation complication.

  10. RADIATION DOSIMETER

    Science.gov (United States)

    Balkwell, W.R. Jr.; Adams, G.D. Jr.

    1960-05-10

    An improvement was made in the determination of amounts of ionizing radiation, particularly low-energy beta particles of less than 1000 rad total dose by means of fluid-phase dosimeter employing a stabilized-- sensitized ferrous-ferric colorimetric system in a sulphuric acid medium. The improvement in the dosimeter consists of adding to the ferrous-ferric system in concentrations of 10/sub -2/ to 10/sup -4/M an organic compound having one or more carboxylic or equivalent groups, such compounds being capable of chelating or complexing the iron ions in the solution. Suitable sensitizing and stabilizing agents are benzoic, phthalic, salicylic, malonic, lactic, maleic, oxalic, citric, succinic, phenolic tartaric, acetic, and adipic acid, as well as other compounds which are added to the solution alone or in certain combinations. As in conventional fluid-phase dosimeters, the absorbed dosage is correlated with a corresponding change in optical density at particular wavelengths of the solution.

  11. Correction of Proofs in "Purely Infinite Simple C*-algebras Arising from Free Product Constructions'' and a Subsequent Paper

    DEFF Research Database (Denmark)

    Ara, Pere; Dykema, Kenneth J.; Rørdam, Mikael

    2013-01-01

    The proofs of Theorem 2.2 of K. J. Dykema and M. Rørdam, Purely infinite simple C∗-algebras arising from free product constructions}, Canad. J. Math. 50 (1998), 323--341 and of Theorem 3.1 of K. J. Dykema, Purely infinite simple C∗-algebras arising from free product constructions, II, Math. Scand...

  12. Radiation tolerant semiconductor sensors for tracking detectors

    CERN Document Server

    Moll, M

    2006-01-01

    The CERN RD50 collaboration “Development of Radiation Hard Semiconductor Devices for Very High Luminosity Colliders” is developing radiation tolerant tracking detectors for the upgrade of the Large Hadron Collider at CERN (Super-LHC). One of the main challenges arising from the target luminosity of 1035 cm−2 s−1 are the unprecedented high radiation levels. Over the anticipated 5 years lifetime of the experiment a cumulated fast hadron fluence of about 1016 cm−2 will be reached for the innermost tracking layers. Further challenges are the expected reduced bunch crossing time of about 10 ns and the high track density calling for fast and high granularity detectors which also fulfill the boundary conditions of low radiation length and low costs. After a short description of the expected radiation damage after a fast hadron fluence of 1016 cm−2, several R&D approaches aiming for radiation tolerant sensor materials (defect and material engineering) and sensor designs (device engineering) are review...

  13. A safe transoral surgical approach to parapharyngeal tumor arising from deep lobe of parotid gland

    Directory of Open Access Journals (Sweden)

    Manuele Casale

    2016-12-01

    Full Text Available The management of parapharyngeal tumor is surgical, but the approach remains a challenge. Attention should be paid to avoidance intra-operative bleeding or cranial nerves damage. We report a case of a 67-year-old male complaining of left-ear fullness. A submucosal mass arising from the lateral wall of oropharynx on the left side was observed. Magnetic resonance imaging detected a mass arising from the parotid gland, in particular from the deep lobe, and a fine needle biopsy was compatible with “Warthin tumor.” We performed a mini-invasive transoral approach under magnification, previous isolation of homolateral vessels. The decision on which surgical approach to be used is determined by site, size vascularity, and histology of the tumor. A literature review of the main surgical approaches was performed. We performed a combined transoral dissection under magnification with cervicotomic exposure of the neck vascular bundle allowing to dissect the tumor and manage any intra-operative complications.

  14. Upper limits on the probability of an interstellar civilization arising in the local Solar neighbourhood

    Science.gov (United States)

    Cartin, Daniel

    2015-10-01

    At this point in time, there is very little empirical evidence on the likelihood of a space-faring species originating in the biosphere of a habitable world. However, there is a tension between the expectation that such a probability is relatively high (given our own origins on Earth), and the lack of any basis for believing the Solar System has ever been visited by an extraterrestrial colonization effort. From the latter observational fact, this paper seeks to place upper limits on the probability of an interstellar civilization arising on a habitable planet in its stellar system, using a percolation model to simulate the progress of such a hypothetical civilization's colonization efforts in the local Solar neighbourhood. To be as realistic as possible, the actual physical positions and characteristics of all stars within 40 parsecs of the Solar System are used as possible colony sites in the percolation process. If an interstellar civilization is very likely to have such colonization programmes, and they can travel over large distances, then the upper bound on the likelihood of such a species arising per habitable world is of the order of 10-3 on the other hand, if civilizations are not prone to colonize their neighbours, or do not travel very far, then the upper limiting probability is much larger, even of order one.

  15. Pancreatic analogue solid pseudopapillary neoplasm arising in the paratesticular location. The first case report.

    Science.gov (United States)

    Michal, Michal; Bulimbasic, Stela; Coric, Marijana; Sedivcova, Monika; Kazakov, Dmitry V; Michal, Michael; Hes, Ondrej

    2016-10-01

    We describe the first pancreatic analogue of solid pseudopapillary neoplasm arising in paratesticular location. It was a tumor arising in 32-year-old man adhering closely to the testis. The tumor had several morphologic components. The greatest was represented by signet ring cells which gradually changed into solid, non-signet ring cell areas, often being mixed together. It also formed distinct trabeculae and pseudopapillae frequently adhering to cystic areas of the tumor. Immunohistochemically, the tumor had an identical profile to its pancreatic counterpart. The tumor cells reacted diffusely with S100 protein, β-catenin, cyclin D1, Fli-1, vimentin, CD10, galectin-3, and neuron-specific enolase and focally with synaptophysin. CD56 and E-cadherin reacted only in those parts of the tumor, which formed pseudopapillae. Cytokeratin antibody AE1-AE3 was strongly positive in the areas of trabecular formation of the tumor. The mutational analysis of exon 3 of the CTNNB1 gene confirmed mutation in this exon. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Central projection of pain arising from delayed onset muscle soreness (DOMS in human subjects.

    Directory of Open Access Journals (Sweden)

    Katharina Zimmermann

    Full Text Available Delayed onset muscle soreness (DOMS is a subacute pain state arising 24-48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1 cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2 areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not.

  17. EBV+ diffuse large B-cell lymphoma arising within atrial myxoma in Chinese immunocompetent patient.

    Science.gov (United States)

    Liu, Xiaoyan; Liu, Pu; Li, Jun

    2015-01-01

    The incidence rate of Primary cardiac lymphoma is very low. Primary cardiac lymphoma within myxoma is extremely rare disease. So far, these cases have been reported only eight in the world, which has not reported in Chinese so far. Hence, we reported the unique Chinese case of 52-year-old immunocompetent male with primary Epstein-Barr virus positive diffuse large B-cell lymphoma arising within atrial myxoma, and had no evidence of systemic lymphoma. The patient presented right sided body numbness, arm weakness no incentive and mouth twitch. A transthoracic echocardiogram revealed a large intraatrial mass, attached to the left atrial wall. The mass was removed by open thoracic surgery and subsequently diagnosed as malignant diffuse large B-cell lymphoma with myxoma by histopathology. This was the fourth case of discovered Epstein-Barr virus positive diffuse large B-cell lymphoma in a cardiac myxoma reported so far. The patient has been well by followed up for 5 months without chemotherapy. Now we discuss the importance of histodiagnosis and the proper treatment. Epstein-Barr virus positive diffuse large B-cell lymphoma arising within atrial myxoma is an extraordinary lymphoma for better prognosis, avoiding excessive treatment.

  18. Ovarian adenosarcoma arising from benign cystadenoma and associated intraoperative consultation pitfalls.

    Science.gov (United States)

    Chen, Zhongchuan Will; Saad, Reda S

    2010-09-01

    An unusual case of ovarian adenosarcoma arising from a smooth-walled serous cystadenoma is described. The ovary was replaced by a multiloculated, fluid-filled cyst without any solid or papillary areas. The malignant component was underdiagnosed during frozen section examination as benign cystadenoma because of the deceptively benign gross appearance of the tumor. On the permanent sections, a phyllodes-like pattern of stromal proliferation and periglandular condensation of atypical stromal cells with a mitotic count of 3 per 10 high-power fields was more apparent and led to the diagnosis of adenosarcoma. The malignant component could not be distinguished from the benign component using immunohistochemical analysis. To our knowledge, this is the first reported case of an adenosarcoma arising from a grossly benign cystadenoma and the third case in the literature of an adenosarcoma associated with a cystadeno(fibro)ma. This case also shows the challenges in differentiating adenosarcoma from a benign counterpart on both frozen and permanent sections.

  19. Data-driven research: open data opportunities for growing knowledge, and ethical issues that arise

    Directory of Open Access Journals (Sweden)

    Aleksandra K Krotoski

    2012-03-01

    Full Text Available The Open Data Initiative in the UK offers incredible opportunities for researchers who seek to gain insight from the wealth of public and institutional data that is increasingly available from government sources – like NHS prescription and GP referral information – or the information we freely offer online. Coupled with digital technologies that can help teams generate connections and collaborations, these data sets can support large-scale innovation and insight. However, by looking at a comparable explosion in data-driven journalism, this article hopes to highlight some of the ethical questions that may arise from big data. The popularity of the social networking service Twitter to share information during the riots in London in August 2011 produced a real-time record of sense-making of enormous interest to academics, reporters and to Twitter users themselves; however, when analysed and published, academic and journalistic interpretations of aggregate content was transformed and individualized, with potential implications for a user-base that was unaware it was being observed. Similar issues arise in academic research with human subjects. Here, the questions of reflexivity in data design and research ethics are considered through a popular media frame.

  20. Near-Infrared Localized Surface Plasmon Resonances Arising from Free Carriers in Doped Quantum Dots

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Prashant K.; Luther, Joey; Ewers, Trevor; Alivisatos, A. Paul

    2010-10-12

    Quantum confinement of electronic wavefunctions in semiconductor quantum dots (QDs) yields discrete atom-like and tunable electronic levels, thereby allowing the engineering of excitation and emission spectra. Metal nanoparticles, on the other hand, display strong resonant interactions with light from localized surface plasmon resonance (LSPR) oscillations of free carriers, resulting in enhanced and geometrically tunable absorption and scattering resonances. The complementary attributes of these nanostructures lends strong interest toward integration into hybrid nanostructures to explore enhanced properties or the emergence of unique attributes arising from their interaction. However, the physicochemical interface between the two components can be limiting for energy transfer and synergistic coupling within such a hybrid nanostructure. Therefore, it is advantageous to realize both attributes, i.e., LSPRs and quantum confinement within the same nanostructure. Here, we describe well-defined LSPRs arising from p-type carriers in vacancy-doped semiconductor quantum dots. This opens up possibilities for light harvesting, non-linear optics, optical sensing and manipulation of solid-state processes in single nanocrystals.

  1. Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin.

    Directory of Open Access Journals (Sweden)

    Sunggu Yang

    Full Text Available Thalamocortical neurons in the dorsal lateral geniculate nucleus (dLGN transfer visual information from retina to primary visual cortex. This information is modulated by inhibitory input arising from local interneurons and thalamic reticular nucleus (TRN neurons, leading to alterations of receptive field properties of thalamocortical neurons. Local GABAergic interneurons provide two distinct synaptic outputs: axonal (F1 terminals and dendritic (F2 terminals onto dLGN thalamocortical neurons. By contrast, TRN neurons provide only axonal output (F1 terminals onto dLGN thalamocortical neurons. It is unclear if GABAA receptor-mediated currents originating from F1 and F2 terminals have different characteristics. In the present study, we examined multiple characteristics (rise time, slope, halfwidth and decay τ of GABAA receptor-mediated miniature inhibitory postsynaptic synaptic currents (mIPSCs originating from F1 and F2 terminals. The mIPSCs arising from F2 terminals showed slower kinetics relative to those from F1 terminals. Such differential kinetics of GABAAR-mediated responses could be an important role in temporal coding of visual signals.

  2. Primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma: A case report

    Directory of Open Access Journals (Sweden)

    Nicolas M. Orsi

    2016-08-01

    Full Text Available Primary ovarian carcinoid tumors are exceptionally rare entities accounting for approximately 0.1% of all ovarian neoplasms. This report describes a primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma in a 65 year-old woman. Macroscopically, the unilateral adnexal tumor was composed of cystic, solid and mucinous elements which resolved into a dual component lesion histologically. The majority of the tumor displayed an organoid architecture with mild to moderate pleomorphism and no discernible mitotic activity, while approximately 10% consisted of sheets and groups of cells with highly pleomorphic nuclei, necrosis and occasional mitoses. Features of a mature cystic teratoma were seen very focally. Immunohistochemistry revealed strong, diffuse positivity for CD56 and synaptophysin. Chromogranin immunonegativity was noted and there was an absence of nuclear β-catenin accumulation. Ki-67 index was 10–12%. Although there is no established diagnostic framework for primary ovarian carcinoid tumors, this case was diagnosed as a well-differentiated neuroendocrine tumor, Grade 2 (intermediate grade, arising in association with a mature cystic teratoma/dermoid cyst. This case highlights the need to develop ovarian diagnostic criteria in this area.

  3. A Study on Problems Arises in Practicing Fire Drill in High Rise Building in Kuala Lumpur

    Directory of Open Access Journals (Sweden)

    Zahari N.F.

    2014-01-01

    Full Text Available Fire drill is one of the steps taken to mitigate the risk trapped in a building during outbreak of fire. Hence, it is very important for every building to practice fire drill, especially high-rise building. Referring to Fire and Rescue Department of Malaysia(BOMBA, high-rise building had a higher risk compared to other type of buildings. However, there might be problems arise to practice fire drill especially in high-rise building. This research intends to study on fire drill procedure and identify any possible common problems arises when practicing fire drill in high-rise building in Kuala Lumpur. Information was gained through regulations and guidelines associated with fire drill procedure and also parties involved in the practice. Besides, a survey is done for awareness of occupants in high-rise building on fire drill practice. For the case study, three high-rise building are selected in Kuala Lumpur based on specific criteria. Analysis for this research comprises of comparative and descriptive approach as well as statistical analysis which are documented based on case studies and questionnaire survey. The findings indicates that there is no standardized procedure in fire drill, while the most common problems that can be seen in practicing fire drill are lack of commitment among occupants, lack of information on fire drill and output on weaknesses after fire drill been practiced.

  4. Differential diagnosis of pancreatic cancer from other solid tumours arising from the periampullary area on MDCT

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Suk Ki [Bundang Jesaeng General Hospital, Departments of Radiology, Daejin Medical Center, Seognam-si, Gyeonggi-do (Korea, Republic of); Kim, Jung Hoon; Joo, Ijin; Jeon, Ju Hyun; Han, Joon Koo; Choi, Byung Ihn [Seoul National University College of Medicine, Department of Radiology and Institute of Radiation Medicine, Chongno-gu, Seoul (Korea, Republic of); Shin, Kyung Sook [Chungnam National University School of Medicine, Department of Radiology, 266 Munhwa-ro, Jung-gu, Daejeon (Korea, Republic of)

    2015-10-15

    To investigate CT features and differential diagnosis of pancreatic adenocarcinoma compared to other solid tumours arising in the periampullary area. One hundred and ninety-five patients with pathologically proven, solid periampullary tumours, including pancreatic adenocarcinoma (n = 98), neuroendocrine tumours (n = 52), gastrointestinal stromal tumours (n = 31), and solid pseudopapillary neoplasms (n = 14), underwent preoperative CT. Two radiologists reviewed CT features and rated the possibility of pancreatic adenocarcinoma. Statistically common findings for pancreatic adenocarcinoma included: patient age >50 years; ill-defined margin; completely solid mass; homogeneous enhancement; hypoenhancement on arterial and venous phases; atrophy; and duct dilatation. Statistically common findings for GIST included: heterogeneous enhancement; hyperenhancement on arterial and venous phases; rim enhancement; and prominent feeding arteries. The hyperenhancement on arterial and venous phases is statistically common in NET, and heterogeneous enhancement, hypoenhancement on the arterial and venous phases are statistically common in SPN. Diagnostic performance of CT for differentiating pancreatic adenocarcinomas from other solid periampullary tumours was 0.962 and 0.977 with excellent interobserver agreement (κ = 0.824). CT is useful not only for differentiating pancreatic adenocarcinoma form other solid tumours but also for differentiating between other solid tumours, including NET, SPN, and GIST, arising in the periampullary area. (orig.)

  5. Papillary Thyroid Microcarcinoma Arising Within a Mature Ovarian Teratoma: Case Report and Review of the Literature

    Science.gov (United States)

    Pineyro, Maria M; Pereda, Jimena; Schou, Pamela; de los Santos, Karina; de la Peña, Soledad; Caserta, Benedicta; Pisabarro, Raul

    2017-01-01

    Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. We report a case of a 34-year-old woman who presented with abdominal pain and an ovarian mass. After surgery, the patient was diagnosed with a follicular variant papillary thyroid microcarcinoma that arose within a mature cystic ovarian teratoma. Based on the small size of the primary lesion and patient preferences, no further treatment was performed. To our knowledge, this is the third reported case of papillary thyroid microcarcinoma arising within a mature ovarian teratoma without struma ovarii. There is no consensus on the surgical approach and postoperative management of this condition. Whether further therapy with total thyroidectomy and radioiodine ablation may be beneficial is unknown. In conclusion, papillary thyroid microcarcinoma can also arise within mature ovarian teratomas. Although a favorable prognosis is anticipated, there is limited information about its history or prognosis. PMID:28615984

  6. Galectin-3 as a Potential Therapeutic Target in Tumors Arising from Malignant Endothelia

    Directory of Open Access Journals (Sweden)

    Kim D. Johnson

    2007-08-01

    Full Text Available Angiosarcoma (ASA in humans, hemangiosarcoma (HSA in dogs are deadly neoplastic diseases characterized by an aggressive growth of malignant cells with endothelial phenotype, widespread metastasis, poor response to chemotherapy. Galectin-3 (Gal-3, a p-galactoside-binding lectin implicated in tumor progression, metastasis, endothelial cell biology, angiogenesis, regulation of apoptosis, neoplastic cell response to cytotoxic drugs, has not been studied before in tumors arising from malignant endothelia. Here, we tested the hypothesis that Gal-3 could be widely expressed in human ASA, canine HSA, could play an important role in malignant endothelial cell biology. Immunohistochemical analysis demonstrated that 100% of the human ASA (10 of 10, canine HSA (17 of 17 samples analyzed expressed Gal-3. Two carbohydrate-based Gal-3 inhibitors, modified citrus pectin (MCP, lactulosyl-l-leucine (LL, caused a dose-dependent reduction of SVR murine ASA cell clonogenic survival through the inhibition of Gal-3 antiapoptotic function. Furthermore, both MCP, LL sensitized SVR cells to the cytotoxic drug doxorubicin to a degree sufficient to reduce the in vitro IC50 of doxorubicin by 10.7-fold, 3.64old, respectively. These results highlight the important role of Gal-3 in the biology of ASA, identify Gal-3 as a potential therapeutic target in tumors arising from malignant endothelial cells.

  7. Carcinosarcoma of monoclonal origin arising in a dermoid cyst of ovary: a case report

    Directory of Open Access Journals (Sweden)

    Di Gangi Claudio

    2006-03-01

    Full Text Available Abstract Background Transformation of a cystic benign teratoma of the ovary into a "carcinosarcoma" has very rarely been reported and its histogenetic origin is still debated. Case presentation A case of carcinosarcoma arising from a dermoid cyst is reported. The tumor showed cystic areas delimited by normal squamous epithelium, with transitional areas through dysplastic epithelium to "in situ" and infiltrating squamous cell carcinoma (SCC. The sarcomatous component showed compact tissue composed of round cells concentrically arranged around small vessels, spindle, and pleomorphic cells with a high nuclear-cytoplasmic ratio. Positive staining for vimentin, alpha smooth muscle actin and CD10, as well as P53 and P63, was found in the sarcomatous component and in some atypical basal cells of the squamous epithelium, which also showed the usual epithelial markers. Conclusion To the best of our knowledge, this is the first case of carcinosarcoma arising from a dermoid cyst in which a histogenetic origin from totipotent stem cells, located in the basal squamous layer, is supported by immunohistochemical findings.

  8. Management of a Prenatally Diagnosed Huge Teratoma Arising from the Soft Palate

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Tamura

    2006-07-01

    Full Text Available Teratomas arising from the oral cavity are relatively rare and can cause life-threatening airway obstruction immediately after birth. We report a case of a huge teratoma arising from the soft palate detected prenatally. To save the patient, a caesarean section and ex utero intrapartum treatment (EXIT were planned at 29 weeks of gestation. However, during EXIT, the patient's cardiopulmonary status deteriorated due to unstable cord blood flow secondary to uterine contractions. EXIT was abandoned, the patient was delivered and an emergency tracheotomy performed. The tumour was successfully excised 4 hours after tracheotomy. The tumour weighed 1,591 g and was 20 × 22 × 12 cm. The patient, a female, weighed 715 g. Histopathology showed Grade II teratoma. The postoperative course was uneventful and she is now 5 years old with no neurological sequelae. EXIT is indicated in patients who have a high risk for airway obstruction immediately after birth. However, if EXIT must be abandoned, as in this case, urgent tracheotomy is mandatory. Planned prevention of airway obstruction at delivery is indispensable for successful outcome and requires excellent coordination among obstetricians, neonatologists, anaesthesiologists and paediatric surgeons.

  9. Radiation chemistry comes before radiation biology.

    Science.gov (United States)

    O'Neill, Peter; Wardman, Peter

    2009-01-01

    This article seeks to illustrate some contributions of radiation chemistry to radiobiology and related science, and to draw attention to examples where radiation chemistry is central to our knowledge of specific aspects. Radiation chemistry is a mature branch of radiation science which is continually evolving and finding wider applications. This is particularly apparent in the study of the roles of free radicals in biology generally, and radiation biology specifically. The chemical viewpoint helps unite the spatial and temporal insight coming from radiation physics with the diversity of biological responses. While historically, the main application of radiation chemistry of relevance to radiation biology has been investigations of the free-radical processes leading to radiation-induced DNA damage and its chemical characterization, two features of radiation chemistry point to its wider importance. First, its emphasis on quantification and characterization at the molecular level helps provide links between DNA damage, biochemical repair processes, and mutagenicity and radiosensitivity. Second, its central pillar of chemical kinetics aids understanding of the roles of 'reactive oxygen species' in cell signalling and diverse biological effects more generally, and application of radiation chemistry in the development of drugs to enhance radiotherapy and as hypoxia-specific cytotoxins or diagnostic agents. The illustrations of the broader applications of radiation chemistry in this article focus on their relevance to radiation biology and demonstrate the importance of synergy in the radiation sciences. The past contributions of radiation chemistry to radiation biology are evident, but there remains considerable potential to help advance future biological understanding using the knowledge and techniques of radiation chemistry.

  10. Black-Body Radiation

    Indian Academy of Sciences (India)

    Keywords. Black-body radiation; thermal radiation; heat; electromagnetic radiation; Stefan's Law; Stefan–Boltzmann Law; Wien's Law; Rayleigh–Jeans Law; black-body spectrum; ultraviolet catastrophe; zero point energy; photon.

  11. Radiation Therapy for Cancer

    Science.gov (United States)

    ... is exposed to radiation. Whether IMRT leads to improved control of tumor growth and better survival compared ... treatments. Some patients may receive radiation therapy and chemotherapy at the same time. The timing of radiation ...

  12. Radiation Exposure and Pregnancy

    Science.gov (United States)

    ... Updated: June 2017 Health Physics Society Specialists in Radiation Safety Radiation Exposure and Pregnancy The birth of a child ... experience. It is In addition to unavoidable background radiation, one hard to prepare yourself for the joys— ...

  13. Thermal radiation heat transfer

    CERN Document Server

    Howell, John R; Siegel, Robert

    2016-01-01

    Further expanding on the changes made to the fifth edition, Thermal Radiation Heat Transfer, 6th Edition continues to highlight the relevance of thermal radiative transfer and focus on concepts that develop the radiative transfer equation (RTE). The book explains the fundamentals of radiative transfer, introduces the energy and radiative transfer equations, covers a variety of approaches used to gauge radiative heat exchange between different surfaces and structures, and provides solution techniques for solving the RTE.

  14. Naturally arising strains of polyomaviruses with severely attenuated microRNA expression.

    Science.gov (United States)

    Chen, Chun Jung; Burke, James M; Kincaid, Rodney P; Azarm, Kristopher D; Mireles, Noel; Butel, Janet S; Sullivan, Christopher S

    2014-11-01

    Several different polyomaviruses (PyVs) encode microRNAs (miRNAs) that regulate viral as well as host gene expression. However, the functions of polyomaviral miRNAs, particularly during in vivo infection, remain poorly understood. Here we identify rare naturally arising PyVs that are severely attenuated or null for miRNA expression. We identify hypomorphic or null strains for miRNA expression from rhesus macaque simian virus 40 (SV40) and human JC virus. These strains were isolated from immunocompromised hosts and derive from insertions or deletions in the viral DNA that preserve the amino acid reading frame of opposing-strand large T antigen gene. Characterization of the SV40 miRNA hypomorph, K661, shows that it is inhibited at the early miRNA biogenesis step of Drosha-mediated processing. Despite having a nonrearranged enhancer, which a previous study has shown renders some PyVs more susceptible to the autoregulatory activities of the miRNA, restoring miRNA expression to K661 has little effect on virus growth in either immortalized or primary monkey kidney cells. Thus, in addition to any effect of accompanying genomic elements, these results suggest that the cellular context also determines susceptibility to PyV miRNA-mediated effects. Combined, these results demonstrate that polyomaviruses lacking miRNAs can arise infrequently and that the functional importance of polyomaviral miRNAs is context dependent, consistent with an activity connected to the immune status of the host. Diverse virus families encode miRNAs, yet much remains unknown about viral miRNA function and contribution to the infectious cycle. Polyomaviruses (PyVs) are small DNA viruses, long known to be important as etiological agents of rare diseases and valuable models of DNA virus infection. Here, in immunosuppressed hosts, we uncover rare naturally arising variants of different PyVs that have lost the ability to express miRNAs. This represents some of the only known natural viruses to have lost

  15. De novo melanoma and melanoma arising from pre-existing nevus: in vivo morphologic differences as evaluated by confocal microscopy.

    Science.gov (United States)

    Longo, Caterina; Rito, Cintia; Beretti, Francesca; Cesinaro, Anna Maria; Piñeiro-Maceira, Juan; Seidenari, Stefania; Pellacani, Giovanni

    2011-09-01

    Although in the majority of melanomas there is no evidence of pre-existing melanocytic nevus, it is believed that malignant transformation may sometimes occur within a benign precursor. We sought to describe the morphologic features of de novo melanoma and melanoma arising from nevi by means of in vivo confocal microscopy, and to correlate them with their corresponding histopathologic features. A total of 113 consecutive, histopathologically proven melanoma cases, 33 arising from a nevus and 80 occurring de novo, were imaged by confocal microscopy and retrospectively evaluated. Cyto-architectural features preferentially expressed in melanomas arising from nevi and in de novo melanomas were defined. By confocal microscopy, abrupt transition, localized distribution of junctional atypical cells, and the presence of dense dermal nests were the most helpful criteria for categorizing a melanoma as arising from a nevus. Melanomas arising from common and congenital nevi were predominantly composed of roundish, monomorphous cells, whereas melanomas arising either de novo or from dysplastic nevi were characterized by markedly pleomorphic cells. The study is retrospective. Confocal microscopy is effective in identifying melanoma even when a nevus is simultaneously present, confirming the clinical usefulness of this methodology. Moreover, distinctive features were observed in de novo melanomas and melanomas arising from nevi, permitting accurate distinction between the two groups. Finally, differences in cell morphology, easily detectable by confocal microscopy, seemed to characterize different melanoma types. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  16. Proxy-produced ethnographic work: what are the problems, issues, and dilemmas arising from proxy ethnography?

    DEFF Research Database (Denmark)

    Martinussen, Marie Louise; Højbjerg, Karin; Tamborg, Andreas Lindenskov

    2018-01-01

    and positions arising from such a setup between the teacher/researcher and the proxy ethnographer/student are found to have implications for the ethnographies produced. This article’s main focus is to show how these relations and positions have not distorted the ethnographic work and the ethnographies but......This article addresses the implications of research-student cooperation in the production of empirical material. For the student to replace the experienced researcher and work under the researcher’s supervision, we call such work proxy-produced ethnographic work. The specific relations...... the research process. These ethnographic distortions will be generated and described within a framework drawn primarily on the work of sociologist Pierre Bourdieu....

  17. Platform and receptacle: Musings of modernity arising from Utzon׳s own houses

    Directory of Open Access Journals (Sweden)

    Xing Ruan

    2016-09-01

    Full Text Available Utzon throughout his life time designed and built three houses for himself and his family. A study of these houses shows the slow development of a doubt, albeit understated, on his early architectural belief that was much celebrated in his public buildings, such as the Sydney Opera House. But Utzon is not unique in this instance. Some other modern architects too had experienced a similar change, gradual or sudden, in their attitudes towards life and the world, hence the transformation of their architecture as a consequence. This change, on the surface and as represented in architecture, is from a building that boldly embraces outside vista to that of a more internalized receptacle. But unlike Corbusier, Utzon, instead of a complete transformation, showed an inner conflict arising from this doubt, which is between the modern urge to conquer the capacious space out there and a yearning for an interior life.

  18. CALCULUS FROM THE PAST: MULTIPLE DELAY SYSTEMS ARISING IN CANCER CELL MODELLING

    KAUST Repository

    WAKE, G. C.

    2013-01-01

    Nonlocal calculus is often overlooked in the mathematics curriculum. In this paper we present an interesting new class of nonlocal problems that arise from modelling the growth and division of cells, especially cancer cells, as they progress through the cell cycle. The cellular biomass is assumed to be unstructured in size or position, and its evolution governed by a time-dependent system of ordinary differential equations with multiple time delays. The system is linear and taken to be autonomous. As a result, it is possible to reduce its solution to that of a nonlinear matrix eigenvalue problem. This method is illustrated by considering case studies, including a model of the cell cycle developed recently by Simms, Bean and Koeber. The paper concludes by explaining how asymptotic expressions for the distribution of cells across the compartments can be determined and used to assess the impact of different chemotherapeutic agents. Copyright © 2013 Australian Mathematical Society.

  19. Estimation of uncertainty arising from different soil sampling devices: the use of variogram parameters.

    Science.gov (United States)

    de Zorzi, Paolo; Barbizzi, Sabrina; Belli, Maria; Barbina, Maria; Fajgelj, Ales; Jacimovic, Radojko; Jeran, Zvonka; Menegon, Sandro; Pati, Alessandra; Petruzzelli, Giannantonio; Sansone, Umberto; Van der Perk, Marcel

    2008-01-01

    In the frame of the international SOILSAMP project, funded and coordinated by the National Environmental Protection Agency of Italy (APAT), uncertainties due to field soil sampling were assessed. Three different sampling devices were applied in an agricultural area using the same sampling protocol. Cr, Sc and Zn mass fractions in the collected soil samples were measured by k(0)-instrumental neutron activation analysis (k(0)-INAA). For each element-device combination the experimental variograms were calculated using geostatistical tools. The variogram parameters were used to estimate the standard uncertainty arising from sampling. The sampling component represents the dominant contribution of the measurement uncertainty with a sampling uncertainty to measurement uncertainty ratio ranging between 0.6 and 0.9. The approach based on the use of variogram parameters leads to uncertainty values of the sampling component in agreement with those estimated by replicate sampling approach.

  20. Youngest case of ductal carcinoma in situ arising within a benign phyllodes tumour: A case report.

    Science.gov (United States)

    Chopra, Sharat; Muralikrishnan, Vummiti; Brotto, Maurizio

    2016-01-01

    Phyllodes tumour (PT) is a rare tumour of the female breast. The tumour clinically and radiologically mimics the features of a fibroadenoma. Ductal carcinoma in situ (DCIS) in the epithelial component of PT is a very rare finding. We present youngest ever case of a 23-year-old nulliparous woman with high-grade ductal carcinoma in situ arising within a benign phyllodes tumor. Macroscopically, it is a homogeneous tumour with solid components. Microscopically, it features typical leaf-like pattern with hypercellular stroma with high-grade ductal carcinoma in situ. To date, eight such rare cases of benign phyllodes tumour with ductal carcinoma in situ have been documented. We report the youngest case known in literature so far. As this is a very rare presentation, it poses several challenges in regard to both management and follow-up. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  1. A case of multiple squamous cell carcinomas arising from red tattoo pigment

    Directory of Open Access Journals (Sweden)

    E. Maxim, BS, MS

    2017-12-01

    Full Text Available Ornamental tattooing involves the administration of exogenous pigments into the skin to create a permanent design. Our case focuses on a 62-year-old woman who presented with an inflamed enlarging nodule on her right proximal calf, which arose within the red pigment of an ornamental tattoo. The nodule was diagnosed as squamous cell carcinoma (SCC and subsequently excised. Over the course of the following year, the patient was diagnosed with a total of five additional SCCs that also arose within the red pigment of the tattoo. The increased popularity of tattooing and the lack of industry safety standards for tattoo ink production, especially metal-laden red pigments, may lead to more cases of skin cancer arising within tattoos among patients of all ages.

  2. Solitary synovial chondromatosis arising in the gluteus maximus bursa: computed tomography and magnetic resonance imaging findings.

    Science.gov (United States)

    Sumida, Kaoru; Kobayashi, Noriko; Nambu, Atsushi; Tago, Masao; Shibuya, Isao; Kawamoto, Masashi

    2016-03-01

    Chondral tumors in soft tissue are referred to as soft-tissue chondromas or extraskeletal chondromas, or as synovial chondromatosis if they arise in synovial tissue. We report the case of a 29-year-old man with synovial chondromatosis, also called synovial osteochondromatosis, which appeared in a solitary and extra-articular form. On magnetic resonance imaging (MRI) and computed tomography, the central portion of the tumor showed similar characteristics to bone marrow, despite the absence of any connection to adjacent bone. T2-weighted imaging displayed marked peripheral hyperintensity consistent with a cartilaginous area. These findings suggested the presence of enchondral ossification and were similar to those of skeletal osteochondroma, with the exception of the absence of attachment to bone. MRI is useful for distinguishing solitary synovial chondromatosis from other lesions, such as myositis ossificans, extraskeletal chondrosarcoma, and parosteal osteosarcoma.

  3. Concurrent Papillary Carcinoma Arising in Thyroglossal Duct Cyst and Thyroid Gland: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyoung Tae; Kim, Yeo Ju; Jeon, Yong Sun; Kim, Youn Jeong [Dept. of Radiology, Inha University School of Medicine, Seoul (Korea, Republic of); Kim, Sei Joong; Cho, Young Up [Dept. of General Surgery, Inha University School of Medicine, Seoul (Korea, Republic of)

    2011-05-15

    The occurrence and diagnosis of thyroglossal duct carcinoma is very rare. The synchronous occurrence of papillary carcinomas arising in a thyroglossal duct cyst (TGDC) and thyroid gland is extremely rare. Sistrunk's surgical technique must always be the initial treatment for a TGDC. However, if there is an intra-thyroidal carcinoma or local invasion, thyroidectomy has to be considered. Accurate pre-operative radiological evaluation should be performed in order to plan a surgical strategy. The aim of this report was to review our experience in the management of papillary thyroid carcinoma associated with TGDC. Our patient was a 67-year-old man who had a mural, micro- calcified nodule within a palpable, thick-walled cyst at the level of the hyoid and synchronously, a small macro-calcified mass in the isthmus of the thyroid gland.

  4. Case report 343: Neurofibroma arising in sympathetic ganglion with probable associated spinal neuroarthopathy (presumptive diagnosis)

    Energy Technology Data Exchange (ETDEWEB)

    Sartoris, D.J.; Jones, H.

    1986-01-01

    In summary, the case of a 50-year-old man with a past medical history of neurofibromatosis is presented. The patient had developed the symptoms and signs of a neurological disorder, which radiologically was localized to the L1-L2 area. Infective spondylitis was simulated, but at surgery a neurofibroma arising from the sympathetic ganglion near L1-L2 was discovered. The clinical, radiological and pathological findings were considered compatible with spinal neuroarthropathy, which has not been reported previously in neurofibromatosis. Due to inherent problems of sampling, associated with a surgical biopsy, the involvement of the L1-L2 are by neurofibromatous tissue without associated Charcot arthropathy cannot be excluded in this case as a tenable diagnosis and indeed the radiological features are consistent with such a diagnosis. (orig./SHA).

  5. Cardiac Sarcoma Arising From Malignant Transformation of a Preexisting Atrial Myxoma.

    Science.gov (United States)

    Nguyen, Anita; Awad, Wael I

    2016-04-01

    A 49-year-old man presented with shortness of breath on exertion, orthopnea, and chest pain. On transthoracic echocardiography, a myxomatous mass was seen in the left atrium. A diagnosis of atrial myxoma was made and the patient underwent urgent surgical intervention. At operation, the mass, which extended into the anterior leaflet of the mitral valve, was excised. Histopathologic examination showed a primary cardiac sarcoma arising within a preexisting atrial myxoma. The patient received no further treatment and died 7 months postoperatively. We report the first case of a malignant transformation of an atrial myxoma to a cardiac sarcoma. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  6. Primary oral squamous cell carcinoma arising around dental osseointegrated implants mimicking peri-implantitis.

    Science.gov (United States)

    Eguia del Valle, Asier; Martínez-Conde Llamosas, Rafael; López Vicente, José; Uribarri Etxebarria, Agurne; Aguirre Urizar, José Manuel

    2008-08-01

    Prosthodontic rehabilitation using dental implants has become a common practice in dentistry at the present time. The number of complications related to dental osseointegrated implants has increased according to the generalization of its use along the last decade. Among the most common of these complications are chronic inflammatory conditions affecting both hard and soft tissues around dental implants. Although severe complications are uncommon, in recent years several cases of oral squamous cell carcinoma adjacent to dental implants have been published. In this paper we present a new unusual case of primary oral squamous cell carcinoma arising around a dental fixed prosthesis over osseointegrated implants in a 76 male patient with no previous history of malignance and no risk factors related to oral cancer.

  7. Stochastic differential equation applied to high frequency data arising in geophysics and other disciplines

    Science.gov (United States)

    Tweneboah, Osei Kofi

    Estimating future seismic hazards of a region constitutes an important study many scholars have shown a renewed interest in the past few decades. A good estimation of the seismic hazard in a region requires predicting the location and magnitude of future seismic events. As the knowledge of the geophysical mechanisms that drive seismic events have increased, so have the corresponding mathematical model representations. This thesis is devoted to the study of modeling geophysical data. We propose a stochastic differential equation arising on the superposition of independent Ornstein-Uhlenbeck processes driven by a Gamma process. Superposition of independent Gamma Ornstein-Uhlenbeck processes offers analytic flexibility and provides a class of continuous time processes capable of exhibiting long memory behavior. The stochastic differential equation is applied to geophysics by fitting the superposed Gamma Ornstein-Uhlenbeck model to high frequency data series in California and Chile.

  8. An analytical method for space–time fractional nonlinear differential equations arising in plasma physics

    Directory of Open Access Journals (Sweden)

    Mohamed Aly Abdou

    2017-12-01

    Full Text Available Here, a new fractional sub-equation method with a fractional complex transform is proposed for constructing exact solutions of fractional partial differential equations arising in plasma physics in the sense of modified Riemann–Liouville derivative, which is the fractional version of the known DξαG(ξG(ξ method. To illustrate the validity of this method, we apply it to the space–time fractional KdV equation on the dust ion acoustic waves in dusty plasma and space–time Boussinesq fractional equation. The proposed approach is efficient and powerful for solving wide classes of nonlinear evolution fractional order equations. The solutions obtained here are new and have not been reported in former literature.

  9. Bio-inspired computational heuristics to study Lane-Emden systems arising in astrophysics model.

    Science.gov (United States)

    Ahmad, Iftikhar; Raja, Muhammad Asif Zahoor; Bilal, Muhammad; Ashraf, Farooq

    2016-01-01

    This study reports novel hybrid computational methods for the solutions of nonlinear singular Lane-Emden type differential equation arising in astrophysics models by exploiting the strength of unsupervised neural network models and stochastic optimization techniques. In the scheme the neural network, sub-part of large field called soft computing, is exploited for modelling of the equation in an unsupervised manner. The proposed approximated solutions of higher order ordinary differential equation are calculated with the weights of neural networks trained with genetic algorithm, and pattern search hybrid with sequential quadratic programming for rapid local convergence. The results of proposed solvers for solving the nonlinear singular systems are in good agreements with the standard solutions. Accuracy and convergence the design schemes are demonstrated by the results of statistical performance measures based on the sufficient large number of independent runs.

  10. A case of primary retroperitoneal mucinous cystadenoma arising from the retropancreatic area.

    Science.gov (United States)

    Nam, Yoon Jeong; Kim, Tae Nyeun; Kim, Kook Hyun; Gu, Min Geun; Lee, Jae Young

    2014-03-25

    Primary retroperitoneal mucinous cystadenoma is an extremely uncommon tumor, even though mucinous cystadenoma often develops in the ovary and less frequently in the pancreas. A 21-year-old female was admitted to our hospital due to severe abdominal pain. A well-demarcated, oval shaped cystic tumor at the retropancreatic area with displacement of the pancreas and surrounding major vessels was observed on CT and MRI. Exploratory laparotomy was performed, and complete excision of the entire cyst was performed without complication. The pathologic finding was consistent with primary retropancreatic mucinous cystadenoma. To the best of our knowledge, this report is the first to describe a case of retropancreatic mucinous cystadenoma arising from the retropancreatic area in Korea.

  11. Wavelet Based Analytical Expressions to Steady State Biofilm Model Arising in Biochemical Engineering.

    Science.gov (United States)

    Padma, S; Hariharan, G

    2016-06-01

    In this paper, we have developed an efficient wavelet based approximation method to biofilm model under steady state arising in enzyme kinetics. Chebyshev wavelet based approximation method is successfully introduced in solving nonlinear steady state biofilm reaction model. To the best of our knowledge, until now there is no rigorous wavelet based solution has been addressed for the proposed model. Analytical solutions for substrate concentration have been derived for all values of the parameters δ and SL. The power of the manageable method is confirmed. Some numerical examples are presented to demonstrate the validity and applicability of the wavelet method. Moreover the use of Chebyshev wavelets is found to be simple, efficient, flexible, convenient, small computation costs and computationally attractive.

  12. Cutaneous mucinous carcinoma arising in extramammary Paget disease of the perineum.

    Science.gov (United States)

    Matin, Rubeta N; Gibbon, Karen; Rizvi, Hasan; Harwood, Catherine A; Cerio, Rino

    2011-10-01

    We present the case of a 74-year-old woman with a 7-year history of an expanding vulval and perianal erythematous plaque, which failed to respond to topical treatments in the community. Biopsy of the affected skin showed typical features of extramammary Paget disease. No underlying associated malignancy was identified. After 2 months of treatment with 5% topical imiquimod, the patient developed a new tender nodule in the perineal region. Histological examination revealed a mucinous carcinoma, which, after careful clinical assessment, was deemed to be a primary cutaneous mucinous carcinoma. This is the second reported case of a primary cutaneous mucinous carcinoma arising on a background of extramammary Paget disease of the vulva and perineum.

  13. A Selective Mutism Arising from First Language Attrition, Successfully Treated with Paroxetine-CBT Combination Treatment.

    Science.gov (United States)

    Serra, Agostino; Di Mauro, Paola; Andaloro, Claudio; Maiolino, Luigi; Pavone, Piero; Cocuzza, Salvatore

    2015-10-01

    After immersion in a foreign language, speakers often have difficulty retrieving native-language words and may experience a decrease in its proficiency, this phenomenon, in the non-pathological form, is known as first language attrition. Self-perception of this low native-language proficiency and apprehension occurring when speaking is expected and, may sometimes lead these people to a state of social anxiety and, in extreme forms, can involve the withholding of speech as a primitive tool for self-protection, linking them to selective mutism. We report an unusual case of selective mutism arising from first language attrition in an Italian girl after attending a two-year "German language school", who successfully responded to a paroxetine-cognitive behavioral treatment (CBT) combination treatment.

  14. A non-local free boundary problem arising in a theory of financial bubbles.

    Science.gov (United States)

    Berestycki, Henri; Monneau, Regis; Scheinkman, José A

    2014-11-13

    We consider an evolution non-local free boundary problem that arises in the modelling of speculative bubbles. The solution of the model is the speculative component in the price of an asset. In the framework of viscosity solutions, we show the existence and uniqueness of the solution. We also show that the solution is convex in space, and establish several monotonicity properties of the solution and of the free boundary with respect to parameters of the problem. To study the free boundary, we use, in particular, the fact that the odd part of the solution solves a more standard obstacle problem. We show that the free boundary is [Formula: see text] and describe the asymptotics of the free boundary as c, the cost of transacting the asset, goes to zero. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  15. A non-local free boundary problem arising in a theory of financial bubbles

    Science.gov (United States)

    Berestycki, Henri; Monneau, Regis; Scheinkman, José A.

    2014-01-01

    We consider an evolution non-local free boundary problem that arises in the modelling of speculative bubbles. The solution of the model is the speculative component in the price of an asset. In the framework of viscosity solutions, we show the existence and uniqueness of the solution. We also show that the solution is convex in space, and establish several monotonicity properties of the solution and of the free boundary with respect to parameters of the problem. To study the free boundary, we use, in particular, the fact that the odd part of the solution solves a more standard obstacle problem. We show that the free boundary is and describe the asymptotics of the free boundary as c, the cost of transacting the asset, goes to zero. PMID:25288815

  16. A problem of estimating a contingency table arising in demographic analysis.

    Science.gov (United States)

    Swee-Hock, S

    1966-03-01

    Abstract This note deals with a special problem of estimating a contingency table arising in demographic analysis. What we require are the estimates of the numbers of births and deaths in Malaya crossclassified by state and race for the years of the Japanese occcupation, 1942-45. For many reasons this period had an adverse effect on the Chinese and Indian Communities, and hence the two-fold result of a greater reduction in the number of births and a larger increase in the number of deaths in states with a smaller proportion of Malay population. The estimates are worked out by means of a technique which takes into consideration this actual demographic situation.

  17. Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.

    Science.gov (United States)

    McCampbell, A S; Mittelstadt, M L; Dere, R; Kim, S; Zhou, L; Djordjevic, B; Soliman, P T; Zhang, Q; Wei, C; Hursting, S D; Lu, K H; Broaddus, R R; Walker, C L

    2016-01-01

    Endometrial carcinoma (EC) exhibits the strongest association with obesity of all cancers. Growth of these tumors is driven by PI3K/AKT activation, and opposed by tumor suppressors, including the tuberous sclerosis complex 2 (TSC-2) and p27, with inactivation of TSC2 and loss or cytoplasmic mislocalization of p27 both being linked to PI3K/AKT activation. However, little is known about the involvement of p27 in the development of EC arising in the setting of obesity, especially its role early in disease progression. Using a panel of EC cell lines, in vitro studies using PI3K inhibitors provided evidence that p27 rescue contributes to the efficacy of interventions that inhibit endometrial cell growth. In "at risk" obese patients, and in an animal model of obesity-associated EC (Tsc2-deficient Eker rats), p27 was moderately-to-severely reduced in both "normal" endometrial glands as well as in endometrial complex atypical hyperplasia (obese women), and endometrial hyperplasia (obese rats). In obese Eker rats, an energy balance intervention; caloric restriction from 2-4 months of age, reduced weight, increased adiponectin and lowered leptin to produce a favorable leptin:adiponectin ratio, and reduced circulating insulin levels. Caloric restriction also increased p27 levels, relocalized this tumor suppressor to the nucleus, and significantly decreased hyperplasia incidence. Thus, dietary and pharmacologic interventions that inhibit growth and decrease risk for development of endometrial lesions are associated with increased expression and nuclear (re)localization of p27. These data suggest that p27 levels and localization may be useful as a biomarker, and possible determinant, of risk for EC arising in the setting of obesity.

  18. Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity

    Science.gov (United States)

    McCampbell, Adrienne S.; Mittelstadt, Megan L.; Dere, Ruhee; Kim, Sunam; Zhou, Lijun; Djordjevic, Bojana; Soliman, Pamela T.; Zhang, Qian; Wei, Caimiao; Hursting, Stephen D.; Lu, Karen H.; Broaddus, Russell R.; Walker, Cheryl Lyn

    2017-01-01

    Endometrial carcinoma (EC) exhibits the strongest association with obesity of all cancers. Growth of these tumors is driven by PI3K/AKT activation, and opposed by tumor suppressors, including the tuberous sclerosis complex 2 (TSC-2) and p27, with inactivation of TSC2 and loss or cytoplasmic mislocalization of p27 both being linked to PI3K/AKT activation. However, little is known about the involvement of p27 in the development of EC arising in the setting of obesity, especially its role early in disease progression. Using a panel of EC cell lines, in vitro studies using PI3K inhibitors provided evidence that p27 rescue contributes to the efficacy of interventions that inhibit endometrial cell growth. In “at risk” obese patients, and in an animal model of obesity-associated EC (Tsc2-deficient Eker rats), p27 was moderately-to-severely reduced in both “normal” endometrial glands as well as in endometrial complex atypical hyperplasia (obese women), and endometrial hyperplasia (obese rats). In obese Eker rats, an energy balance intervention; caloric restriction from 2–4 months of age, reduced weight, increased adiponectin and lowered leptin to produce a favorable leptin:adiponectin ratio, and reduced circulating insulin levels. Caloric restriction also increased p27 levels, relocalized this tumor suppressor to the nucleus, and significantly decreased hyperplasia incidence. Thus, dietary and pharmacologic interventions that inhibit growth and decrease risk for development of endometrial lesions are associated with increased expression and nuclear (re)localization of p27. These data suggest that p27 levels and localization may be useful as a biomarker, and possible determinant, of risk for EC arising in the setting of obesity. PMID:26917264

  19. [Hospital emergencies arising from nursing homes in a region: evolution, characteristics and appropriateness].

    Science.gov (United States)

    Sánchez-Pérez, Inma; Comes Garcia, Nuri; Romero Piniella, Lola; Prats Martos, Gemma; Arnau Bataller, Gemma; Coderch, Jordi

    2017-02-10

    Hospital emergencies (HE) arising from nursing homes (NH) are on the rise. We analyse the evolution, characteristics and appropriateness of HE of NH residents in a region, as well as resulting hospital admissions. Retrospective descriptive study between 2010 and 2013 of institutionalised residents of 11 NH located in Baix Empordà (704 beds) and Palamós Hospital. Gender, age, morbidity and relative weight according to clinical risk groups (CRG), NH, length of stay, diagnosis of the emergency, appropriateness of HE according to Bermejo's criteria and the HE appropriateness protocol (HEAP), and appropriateness of hospitalisations according to the Appropriateness Evaluation Protocol (AEP). Sample to evaluate appropriateness: 159 HE and 91 hospitalisations. frequency, mean, standard deviation, percentiles, Fisher's exact test and ANOVA, with a confidence interval of 95% and using IBM SPSS Statistics 23. 1,474 people were enrolled, of which 73% were women. Group ≥85 years increased to 60.3% and the mean weight of morbidity was 3.2 to 4.0 (p <0.001). 1,805 HE were generated. The annual rate per 1,000 stays arising from NH increased from 1.64 to 2.05, of which 90.6% were appropriate according to Bermejo's criteria and 93.7% according to the HEAP. Of these, 502 involved hospitalisation. The annual rate per 10 emergencies fell from 2.96 to 2.64 and 98.9% were appropriate according to the AEP. Hospital emergencies and hospitalisations of NH residents are increasing and are appropriate. Increasing age and disease burden could explain this phenomenon. NH and hospitals should react appropriately, considering the specific needs of this population sector. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  20. Gliosarcomas arising from the pineal gland region: uncommon localization and rare tumors.

    Science.gov (United States)

    Sugita, Yasuo; Terasaki, Mizuhiko; Tanigawa, Ken; Ohshima, Koichi; Morioka, Motohiro; Higaki, Koichi; Nakagawa, Setsuko; Shimokawa, Shoko; Nakashima, Susumu

    2016-02-01

    Gliosarcomas are a variant of glioblastomas and present a biphasic pattern, with coexisting glial and mesenchymal components. In this study, two unusual cases are presented. Case 1 is a 52-year-old woman with a headache and memory disturbance for a month. Case 2 is an 18-year-old man with a headache lasting two weeks. In both cases, an MRI revealed enhancing T1-low to iso, T2-iso to high intensity lesions in the pineal gland region. Histologically, in case 1, the tumor showed spindle cell proliferation with disorganized fascicles and cellular pleomorphism. Tumor cells variously exhibited oncocytic transformation. Immunohistochemically, most of the spindle tumor cells were positive for myoglobin and desmin. Some of the tumor cells were positive for GFAP and S-100 protein. On the other hand, all tumor cells were positive for CD133, Musashi1, and SOX-2 which are the markers of neural stem cells. In case 2, the tumor showed monotonous proliferation of short spindle cells with disorganized fascicles and cellular atypism. The morphological distinction between glial and mesenchymal components was not apparent. Immunohistochemically, most of the spindle tumor cells were positive for desmin. Glial tumor cells that were dispersed within the sarcoma as single cells were positive for GFAP. In addition, all tumor cells were positive for CD133, Musashi1 and SOX-2. Based on these microscopic appearances, and immunohistochemical findings, these cases were diagnosed as gliosarcomas arising from the pineal gland region. These results also indicated that pluripotential cancer stem cells differentiated into glial and muscle cell lines at the time of tumor growth. In a survey of previous publications on gliosarcoma arising from the pineal gland, these cases are the second and third reports found in English scientific writings. © 2015 Japanese Society of Neuropathology.

  1. Interference between source-free radiation and radiation from sources: Particle-like behavior for classical radiation

    Science.gov (United States)

    Boyer, Timothy H.

    2017-09-01

    A simple junior-level electrodynamics problem is used to illustrate the interference between a source-free standing plane wave and a wave generated by a pulse in a current sheet. Depending upon the relative phases between the standing wave and the current pulse and also upon the relative magnitudes, we can find quite different patterns of emitted energy and momentum. If the source gives a large radiation pulse so that the source-free plane wave can be neglected, then the radiation spreads out symmetrically on either side of the current sheet. However, if the radiation sheet gives a pulse with fields comparable to those of the standing wave, then we can find a single radiation pulse moving to the right while the current sheet recoils to the left or the situation with the directions reversed. The example is a crude illustration of particle-like behavior arising from conventional classical electromagnetic behavior in the presence of source-free radiation. The discussion makes contact with the ideas of photons in modern physics.

  2. [Radiation protection. Implications for clinical practice on the new regulations governing roentgen ray irradiation and radioprotection].

    Science.gov (United States)

    Nestle, U; Berlich, J

    2006-08-01

    In 2001 or 2002, the legislator made substantial alterations to the "Röntgenverordnung" [regulations governing use of roentgen ray radiation] and "Strahlenschutzverordnung" [regulations governing radiation protection]. This was done to bring German law in line with EU Directives 96/29/Euratom (basic safety standards for the protection of the health of workers and the general public against the dangers arising from ionizing radiation) and 97/43/Euratom (health protection of individuals against the dangers of ionizing radiation in relation to medical exposure). Proper use of radiation in medicine requires that those involved in its application are aware of the biological effect of radiation. When staff and others are protected good organization and appropriate technology at the workplace can achieve a great deal. In the new directives, the radiation protection for the patient is quantified and the responsibility of the physician is clearly pointed out. The most important aim is uniform quality throughout Europe in radiological diagnosis and radiation protection.

  3. Gravitation radiation observations

    OpenAIRE

    Glass, E. N.

    2017-01-01

    The notion of gravitational radiation begins with electromagnetic radiation. In 1887 Heinrich Hertz, working in one room, generated and received electromagnetic radiation. Maxwell's equations describe the electromagnetic field. The quanta of electromagnetic radiation are spin 1 photons. They are fundamental to atomic physics and quantum electrodynamics.

  4. Detection of Terahertz Radiation

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a system for detecting terahertz radiation, a camera device, and a method for detecting terahertz radiation.......The present invention relates to a system for detecting terahertz radiation, a camera device, and a method for detecting terahertz radiation....

  5. Primary mediastinal large B-cell lymphoma arising from thyroid in a renal recipient with Hashimoto’s thyroiditis

    OpenAIRE

    Wu, Fang; Qu, Lu; Li, Dai-Qiang; Hu, Chun-Hong

    2015-01-01

    Primary mediastinal large B-cell lymphoma is a subtype of diffuse large B-cell lymphoma, arising in the mediastinum from putative thymic B-cell origin with distinctive clinical and genetic features. Generally, primary mediastinal large B-cell lymphoma is believed as only deriving in the mediastinum. The current study presents a rare case of primary mediastinal large B-cell lymphoma which arising from thyroid in a renal recipient with Hashimoto’s thyroiditis. Moreover, we devoted a discussion ...

  6. Model of a laser heated plasma interacting with walls arising in laser keyhole welding

    Science.gov (United States)

    Tix, C.; Simon, G.

    1994-07-01

    In laser welding with laser intensities of approximately 1011 W/m2, a hole, called a keyhole, is formed in the material. In this keyhole a plasma is detected, which is characterized by high pressure as well as being influenced by the boundary of the keyhole. Experimental data on plasma parameters are rare and difficult to obtain [W. Sokolowski, G. Herziger, and E. Beyer, in High Power Lasers and Laser Machining Technology, edited by A. Quenzer, SPIE Proc. Vol. 1132 (SPIE, Bellingham, WA, 1989), pp. 288-295]. In a previous paper [C. Tix and G. Simon, J. Phys. D 26, 2066 (1993)] we considered just a simple plasma model without excited states and with constant ion-neutral-atom temperature. Therefore we neglected radiative transport of excitations and underestimated the ion-neutral-atom temperature and the ionization rate. Here we extend our previous model for a continuous CO2 laser and iron and take into account radiative transfer of excitations and a variable ion-neutral-atom temperature. We consider singly charged ions, electrons, and three excitation states of neutral atoms. The plasma is divided in plasma bulk, presheath, and sheath. The transport equations are solved with boundary conditions mainly determined through the appearance of walls. Some effort is made to clarify the energy transport mechanism from the laser beam into the material. Dependent on the incident laser power, the mean electron temperature and density are obtained to be 1.0-1.3 eV and 2.5×1023-3×1023 m-3. Radiative transport of excitations does not contribute significantly to the energy transport.

  7. Serf studies of mass motions arising in flares. [Study of Energy Release in Flares

    Science.gov (United States)

    Wagner, W. J.

    1982-01-01

    It is believed that radio type IVs, co-spatial with dense hot plasmoids, may be the result of a plasma radiation emission mechanism. The injection of mass into the corona was recently observed in chromospheric and coronal lines with magnetic field changes and also at very high speeds into loops. The start time of coronal loop transients, if extrapolated to the chromosphere, in most cases precedes flare H-alpha or X-ray emission. Observational inferences from polarization and other studies are seen as favoring the three-dimensional bubble over the planar loop as a description of coronal mass motions.

  8. Ganglioglioma Arising From Desmoplastic Medulloblastoma: A Case Report and Review of Literature.

    Science.gov (United States)

    Valvi, Santosh; Ziegler, David S

    2017-03-01

    We describe a case of medulloblastoma maturating into ganglioglioma during therapy. A 10-month-old boy was diagnosed with a desmoplastic medulloblastoma and was treated with gross total resection followed by induction chemotherapy. A recurrence in the tumor bed during therapy was managed with focal radiation therapy and consolidation chemotherapy. After further progression, the recurrent tumor was resected completely. The histopathology revealed a benign ganglioglioma with no residual medulloblastoma. This case raises the possibility that a malignant medulloblastoma can differentiate into a benign tumor and suggests that differentiation therapy may have value in the treatment of medulloblastoma. Copyright © 2017 by the American Academy of Pediatrics.

  9. Left main stem/LCA arising from right coronary sinus with an interarterial course.

    Science.gov (United States)

    Waleed, Mohammad; Raza, Ali; Minhaj, Tariq; Houghton, Timothy

    2014-07-11

    A 67-year-old woman presented to the accident and emergency department with central chest pain for the past 4 months. She described the pain as severe, retrosternal, intermittent, indigestion/burning type, with radiations to the left arm. She had used antacids with no relief. Her medical history included hypertension, chronic obstructive pulmonary disease, pulmonary fibrosis, left mastectomy for breast cancer, hypercholesterolaemia and osteoarthritis. Her medications included anastrazole, indapamide, perindopril, aspirin, clopidogrel, atorvastatin, salbutamol and atrovent inhalers. She was a non-smoker and vegetarian. Two brothers each had a myocardial infarction when in their early 40s. 2014 BMJ Publishing Group Ltd.

  10. Thermal radiation heat transfer.

    Science.gov (United States)

    Siegel, R.; Howell, J. R.

    1972-01-01

    A comprehensive discussion of heat transfer by thermal radiation is presented, including the radiative behavior of materials, radiation between surfaces, and gas radiation. Among the topics considered are property prediction by electromagnetic theory, the observed properties of solid materials, radiation in the presence of other modes of energy transfer, the equations of transfer for an absorbing-emitting gas, and radiative transfer in scattering and absorbing media. Also considered are radiation exchange between black isothermal surfaces, radiation exchange in enclosures composed of diffuse gray surfaces and in enclosures having some specularly reflecting surfaces, and radiation exchange between nondiffuse nongray surfaces. The use of the Monte Carlo technique in solving radiant-exchange problems and problems of radiative transfer through absorbing-emitting media is explained.

  11. [Diagnosis and treatment of diffuse tenosynovial giant cell tumor arising from temporomandibular joints].

    Science.gov (United States)

    Meng, J H; Guo, Y X; Luo, H Y; Guo, C B; Ma, X C

    2016-12-18

    To retrospectively analyze the clinical features, treatment and prognosis to the diffuse tenosynovial giant cell tumor (D-TSGCT) arising from the temporomandibular joint (TMJ), and to give a reference for the early diagnosis and treatment of this disease. In this study, 15 patients finally diagnosed as D-TSGCT of TMJ histopathologically at the Peking University Hospital of Stomatology from October 2003 to August 2015 were selected and reviewed. Their clinical manifestations, imaging and histological features, diagnoses and differential diagnoses, treatments and follow-ups were summarized and discussed. D-TSGCT of TMJ showed obvious female predominance (12/15), the main symptoms included painful preauricular swelling or mass, limited mouth-opening and mandibular deviation with movement. D-TSGCT on computed tomography (CT) scan often showed ill-defined soft tissue masses around TMJ, enhancement after contrast administration, usually with widening of the joint spaces and with bone destruction of the condyle, the fossa and even the skull base. On magnetic resonance images (MRI), the majority of lesions on T1 weighted images and T2 weighted images both showed the characteristics of low signals (6/11). The lesions could extend beyond the joints (9/11) and into the infratemporal fossa (4/11) and the middle cranial fossa (4/11). Surgical resection was performed in 14 cases and biopsy in 1 case. Postoperative radiotherapy was performed in 3 cases. In follow-ups, 3 cases showed recurrence postoperatively. D-TSGCT arising from TMJ should be differentiated with TMJ disorders, other tumors and tumor-like lesions of TMJ and parotid neoplasms, etc. CT and MRI examinations have important values in the diagnosis and treatment design of D-TSGCT. Because of the local aggressive and extensive behavior, complete resection should be performed as soon as possible. Postoperative radiotherapy was helpful for the extensive lesions including destruction of skull base and may be a good

  12. The clinico-anatomic explanation for tibial intraneural ganglion cysts arising from the superior tibiofibular joint.

    Science.gov (United States)

    Spinner, Robert J; Mokhtarzadeh, Ali; Schiefer, Terry K; Krishnan, Kartik G; Kliot, Michel; Amrami, Kimberly K

    2007-04-01

    To demonstrate that tibial intraneural ganglia in the popliteal fossa are derived from the posterior portion of the superior tibiofibular joint, in a mechanism similar to that of peroneal intraneural ganglia, which have recently been shown to arise from the anterior portion of the same joint. Retrospective clinical study and prospective anatomic study. The clinical records and MRI findings of three patients with tibial intraneural ganglion cysts were analyzed and compared with those of one patient with a tibial extraneural ganglion cyst and one volunteer. Seven cadaveric limbs were dissected to define the articular anatomy of the posterior aspect of the superior tibiofibular joint. The condition of the three patients with intraneural ganglia recurred because their joint connections were not identified initially. In two patients there was no cyst recurrence when the joint connection was treated at revision surgery; the third patient did not wish to undergo additional surgery. The one patient with an extraneural ganglion had the joint connection identified at initial assessment and had successful surgery addressing the cyst and the joint connection. Retrospective evaluation of the tibial intraneural ganglion cysts revealed stereotypic features, which allowed their accurate diagnosis and distinction from extraneural cases. The intraneural cysts had tubular (rather than globular) appearances. They derived from the postero-inferior portion of the superior tibiofibular joint and followed the expected course of the articular branch on the posterior surface of the popliteus muscle. The cysts then extended intra-epineurially into the parent tibial nerves, where they contained displaced nerve fascicles. The extraneural cyst extrinsically compressed the tibial nerve but did not directly involve it. All cadaveric specimens demonstrated a small single articular branch, which derived from the tibial nerve to the popliteus. The branch coursed obliquely across the posterior

  13. Radiation by moving charges

    Energy Technology Data Exchange (ETDEWEB)

    Geloni, Gianluca [European XFEL GmbH, Hamburg (Germany); Kocharyan, Vitali; Saldin, Evgeni [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2017-04-15

    It is generally accepted that in order to describe the dynamics of relativistic particles in the laboratory (lab) frame it is sufficient to take into account the relativistic dependence of the particle momenta on the velocity. This solution of the dynamics problem in the lab frame makes no reference to Lorentz transformations. For this reason they are not discussed in particle tracking calculations in accelerator and plasma physics. It is generally believed that the electrodynamics problem can be treated within the same ''single inertial frame'' description without reference to Lorentz transformations. In particular, in order to evaluate radiation fields arising from charged particles in motion we need to know their velocities and positions as a function of the lab frame time t. The relativistic motion of a particle in the lab frame is described by Newton's second law ''corrected'' for the relativistic dependence of momentum on velocity. It is assumed in all standard derivations that one can perform identification of the trajectories in the source part of the usual Maxwell's equations with the trajectories vector x(t) measured (or calculated by using the corrected Newton's second law) in the lab frame. This way of coupling fields and particles is considered since more than a century as the relativistically correct procedure.We argue that this procedure needs to be changed, and we demonstrate the following, completely counterintuitive statement: the results of conventional theory of radiation by relativistically moving charges are not consistent with the principle of relativity. In order to find the trajectory of a particle in the lab frame consistent with the usual Maxwell's equations, one needs to solve the dynamic equation inmanifestly covariant form by using the coordinate-independent proper time τ to parameterize the particle world-line in space-time. We show that there is a difference between &apos

  14. Primary adenocarcinoid tumor of the ovary arising in mature cystic teratoma. A case report.

    Science.gov (United States)

    Gungor, T; Altinkaya, O; Ozat, M; Sirvan, L; Yalcin, H; Mollamahmutoglu, L

    2009-01-01

    Primary carcinoid tumors of the ovary are rare, forming 0.3 % of all carcinoid tumors and less than 0.1 % of ovarian malignancies. We present a case of a 47-year-old woman with abnormal vaginal bleeding and abdominal discomfort. Pelvic ultrasonography revealed a right-sided, 4 cm solid ovarian mass. At laparoscopy, a smooth surfaced, firm and mobile right adnexal mass with solid and cystic portions was detected and the tumor was excised. Pathologic and immunohistochemical examination revealed carcinoid tumor. After the evaluation of gastrointestinal and respiratory systems by imaging and endoscopic studies, no evidence of tumor tissue or metastases were found. Based on this finding, total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendectomy were performed and pelvic-paraaortic lymph nodes were also removed. All histological findings were similar to the features of mature cystic teratoma and carcinoid tumor. Examination of the resected lymphatic, omental and appendiceal tissue indicated no tumoral invasion. Thus, the diagnosis was primary ovarian carcinoid arising from a mature cystic teratoma. This case, in the setting of a normal appendix and negative workup for an extraovarian origin, is one of a primary ovarian adenocarcinoid tumor. The primary carcinoid tumor should be differentiated from a metastatic carcinoid inside the ovary, which is always bilateral. It is important to be aware of this unusual entity in diagnoses of ovarian tumors, even in the absence of any clinical symptoms of carcinoid syndrome.

  15. Elucidating the relationship between work attention performance and emotions arising from listening to music.

    Science.gov (United States)

    Shih, Yi-Nuo; Chien, Wei-Hsien; Chiang, Han-Sun

    2016-10-17

    In addition to demonstrating that human emotions improve work attention performance, numerous studies have also established that music alters human emotions. Given the pervasiveness of background music in the workplace, exactly how work attention, emotions and music listening are related is of priority concern in human resource management. This preliminary study investigates the relationship between work attention performance and emotions arising from listening to music. Thirty one males and 34 females, ranging from 20-24 years old, participated in this study following written informed consent. A randomized controlled trial (RCT) was performed in this study, which consisted of six steps and the use of the standard attention test and emotion questionnaire. Background music with lyrics adversely impacts attention performance more than that without lyrics. Analysis results also indicate that listeners self-reported feeling "loved" while music played that implied a higher score on their work-attention performance. Moreover, a greater ability of music to make listeners feel sad implied a lower score on their work-attention performance. Results of this preliminary study demonstrate that background music in the workplace should focus mainly on creating an environment in which listeners feel loved or taken care and avoiding music that causes individuals to feel stressed or sad. We recommend that future research increase the number of research participants to enhance the applicability and replicability of these findings.

  16. Abscess of the orbit arising 48 h after root canal treatment of a maxillary first molar.

    Science.gov (United States)

    Koch, F; Breil, P; Marroquín, B B; Gawehn, J; Kunkel, M

    2006-08-01

    To discuss a rare, but severe complication arising following routine root canal treatment. An orbital abscess is reported that occurred following routine root canal treatment. A young, healthy female patient, with no history of chronic paranasal infection had undergone root canal treatment of the right maxillary first molar. On hospital admission, she presented with extensive periorbital swelling and discreet diplopia. Computed tomography imaging identified massive purulent sinusitis and subsequent involvement of the orbit via the inferior and medial orbital wall within 48 h after completion of root canal treatment. Immediate surgical drainage of the maxillary sinus and the orbit was established and a high dose of perioperative antibiotics (Amoxicillin/Clavulanic acid, Gentamycin, Metronidazole) were administered. Vision remained undisturbed and mobility of the globe recovered within 10 days. Rapid exacerbation of a periapical inflammation may occur following root canal treatment and may even involve the orbit. A typical speed of disease progression or ophthalmic symptoms should alert the clinician to at least consider unusual early orbital spread of odontogenic infection. When extra-alveolar spread and especially orbital spread is suspected, immediate referral to a maxillofacial or other specialized unit is mandatory.

  17. Self: an adaptive pressure arising from self-organization, chaotic dynamics, and neural Darwinism.

    Science.gov (United States)

    Bruzzo, Angela Alessia; Vimal, Ram Lakhan Pandey

    2007-12-01

    In this article, we establish a model to delineate the emergence of "self" in the brain making recourse to the theory of chaos. Self is considered as the subjective experience of a subject. As essential ingredients of subjective experiences, our model includes wakefulness, re-entry, attention, memory, and proto-experiences. The stability as stated by chaos theory can potentially describe the non-linear function of "self" as sensitive to initial conditions and can characterize it as underlying order from apparently random signals. Self-similarity is discussed as a latent menace of a pathological confusion between "self" and "others". Our test hypothesis is that (1) consciousness might have emerged and evolved from a primordial potential or proto-experience in matter, such as the physical attractions and repulsions experienced by electrons, and (2) "self" arises from chaotic dynamics, self-organization and selective mechanisms during ontogenesis, while emerging post-ontogenically as an adaptive pressure driven by both volume and synaptic-neural transmission and influencing the functional connectivity of neural nets (structure).

  18. Squamous Cell Carcinoma Arising in Hypertrophic Lichen Planus: A Review and Analysis of 38 Cases.

    Science.gov (United States)

    Knackstedt, Thomas J; Collins, Lindsey K; Li, Zhongze; Yan, Shaofeng; Samie, Faramarz H

    2015-12-01

    Hypertrophic lichen planus is a chronic variant of lichen planus with controversial malignant association. To describe and analyze the relationship of squamous cell carcinoma (SCC) and hypertrophic lichen planus. A retrospective chart review of patients with hypertrophic lichen planus and SCC was performed at the authors' institution. Thereafter, scientific databases were searched for articles reporting cases of SCC arising in hypertrophic lichen planus. Patient demographics, immune status, lichen planus features, and SCC data points were extracted for each patient and evaluated. Thirty-eight cases of SCC in hypertrophic lichen planus occurred in 16 women, average age: 61.4, and 22 men, average age: 51.3, after a lag time of 88 days to 40 years. Squamous cell carcinoma was uniformly located on the lower extremity. Men had larger SCC than women (p = .027) and a significantly longer lag time to SCC development (p = .002). Long lag time was associated with a smaller SCC size (p = .032). In the past, hypertrophic lichen planus and SCC have been considered isolated diseases. Based on an increasing number of cases, the association between hypertrophic lichen planus and keratinocyte malignancies warrants surveillance.

  19. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.

    Science.gov (United States)

    Cheung, Kevin J; Padmanaban, Veena; Silvestri, Vanesa; Schipper, Koen; Cohen, Joshua D; Fairchild, Amanda N; Gorin, Michael A; Verdone, James E; Pienta, Kenneth J; Bader, Joel S; Ewald, Andrew J

    2016-02-16

    Recent genomic studies challenge the conventional model that each metastasis must arise from a single tumor cell and instead reveal that metastases can be composed of multiple genetically distinct clones. These intriguing observations raise the question: How do polyclonal metastases emerge from the primary tumor? In this study, we used multicolor lineage tracing to demonstrate that polyclonal seeding by cell clusters is a frequent mechanism in a common mouse model of breast cancer, accounting for >90% of metastases. We directly observed multicolored tumor cell clusters across major stages of metastasis, including collective invasion, local dissemination, intravascular emboli, circulating tumor cell clusters, and micrometastases. Experimentally aggregating tumor cells into clusters induced a >15-fold increase in colony formation ex vivo and a >100-fold increase in metastasis formation in vivo. Intriguingly, locally disseminated clusters, circulating tumor cell clusters, and lung micrometastases frequently expressed the epithelial cytoskeletal protein, keratin 14 (K14). RNA-seq analysis revealed that K14(+) cells were enriched for desmosome and hemidesmosome adhesion complex genes, and were depleted for MHC class II genes. Depletion of K14 expression abrogated distant metastases and disrupted expression of multiple metastasis effectors, including Tenascin C (Tnc), Jagged1 (Jag1), and Epiregulin (Ereg). Taken together, our findings reveal K14 as a key regulator of metastasis and establish the concept that K14(+) epithelial tumor cell clusters disseminate collectively to colonize distant organs.

  20. Thyroid papillary carcinoma arising in ectopic thyroid tissue within a neck branchial cyst

    Directory of Open Access Journals (Sweden)

    Di Fiore Agnese

    2006-05-01

    Full Text Available Abstract Background Thyroid gland derives from one median anlage at the base of the tongue, and from the two fourth branchial pouches. A number of anomalies may occur during their migration. These can be in form of ectopic tissues, which are frequently found along the course of thyroglossal duct and rarely in other sites, many of these may develop same diseases as the thyroid gland. Case presentation A 36-years-old female presented with a 3 month history of left side neck mass. The mass disappeared following aspiration of brown colored fluid, which on cytological examination showed cells with nuclear irregularities that warranted the resection of the lesion. The histology demonstrated a thyroid papillary carcinoma arising within the branchial cyst. Thereafter, the patient underwent a total thyroidectomy with central lymph nodes dissection. Histology showed a multifocal papillary carcinoma with central lymph nodes metastases. Only four cases of primary thyroid carcinomas in neck branchial cyst have been described so far. Conclusion In a lateral cystic neck mass, although rare, occurrence of ectopic thyroid tissue and presence of a papillary thyroid carcinoma should be kept in mind.

  1. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

    Science.gov (United States)

    Cheung, Kevin J.; Padmanaban, Veena; Silvestri, Vanesa; Schipper, Koen; Cohen, Joshua D.; Fairchild, Amanda N.; Gorin, Michael A.; Verdone, James E.; Pienta, Kenneth J.; Bader, Joel S.; Ewald, Andrew J.

    2016-01-01

    Recent genomic studies challenge the conventional model that each metastasis must arise from a single tumor cell and instead reveal that metastases can be composed of multiple genetically distinct clones. These intriguing observations raise the question: How do polyclonal metastases emerge from the primary tumor? In this study, we used multicolor lineage tracing to demonstrate that polyclonal seeding by cell clusters is a frequent mechanism in a common mouse model of breast cancer, accounting for >90% of metastases. We directly observed multicolored tumor cell clusters across major stages of metastasis, including collective invasion, local dissemination, intravascular emboli, circulating tumor cell clusters, and micrometastases. Experimentally aggregating tumor cells into clusters induced a >15-fold increase in colony formation ex vivo and a >100-fold increase in metastasis formation in vivo. Intriguingly, locally disseminated clusters, circulating tumor cell clusters, and lung micrometastases frequently expressed the epithelial cytoskeletal protein, keratin 14 (K14). RNA-seq analysis revealed that K14+ cells were enriched for desmosome and hemidesmosome adhesion complex genes, and were depleted for MHC class II genes. Depletion of K14 expression abrogated distant metastases and disrupted expression of multiple metastasis effectors, including Tenascin C (Tnc), Jagged1 (Jag1), and Epiregulin (Ereg). Taken together, our findings reveal K14 as a key regulator of metastasis and establish the concept that K14+ epithelial tumor cell clusters disseminate collectively to colonize distant organs. PMID:26831077

  2. The pathogenesis of ovarian myxoma: a neoplasm sometimes arising from other ovarian stromal tumors.

    Science.gov (United States)

    Roth, Lawrence M; Gaba, Arthur R; Cheng, Liang

    2013-07-01

    Ovarian myxoma is a rare distinctive benign ovarian stromal neoplasm that occurs predominantly in young women and is hormonally inactive. Although typically classified as an ovarian stromal tumor, its exact pathogenesis remains uncertain. We report 4 cases of ovarian myxoma, 3 of which were associated with another type or other types of ovarian stromal tumor and 1 occurred as a pure myxoma. In 2 cases, the myxoma arose from a sclerosing stromal tumor, and the third, most likely arose from a luteinized theca cell tumor (LTCT). Myxoid transformation of the connective tissue of the parent neoplasm appears to be a precursor of ovarian myxoma in some instances. We believe that the occurrence of trisomy 12 or other genetic abnormalities may play a role in this transformation. Whether or not associated with another type of ovarian stromal tumor, ovarian myxoma can be suspected macroscopically by its cystic gelatinous appearance and sharp circumscription. The most important differential diagnosis is a low-grade sarcoma with myxomatous features. We believe that myxomas arising from different anatomic sites likely are genetically, histologically, and biologically distinct. For purposes of classification, they should be considered as separate tumor types.

  3. Basaloid ductal carcinoma in situ arising in salivary gland metaplasia of the breast: a case report.

    Science.gov (United States)

    Jang, Eun Jeong; Kang, Su Hwan; Bae, Young Kyung

    2014-01-01

    Salivary gland metaplasia is a newly recognized, adenosis-like lesion which could not be classified according to known categories of adenosis of the breast. We report a case of basaloid ductal carcinoma in situ (DCIS) arising in a background of salivary gland metaplasia in a 49-year old woman who visited our hospital for a right breast mass. Breast ultrasonography showed a multi-lobulating mixed hypoechoic and isoechoic mass measuring 2.9 cm in size at the periareolar area. Histologically, the lesion showed a well-defined DCIS with basaloid tumor cells and central comedo-type necrosis surrounded by salivary gland metaplasia composed of glands or ducts not specific to the breast, ducts with cribriform proliferation of luminal epithelial cells, and ducts with varying degrees of proliferation of basaloid cells including solid nests of basaloid cells. Salivary gland metaplasia is a most unusual lesion of the breast characterized by salivary gland-type acini and ducts with various proliferations of luminal and basaloid cells, and accompanied by malignant tumor of basal cell type.

  4. Atmospheric dynamics Research InfraStructure in Europe: The ARISE Project

    Science.gov (United States)

    Blanc, E.; Bittner, M.; Hauchecorne, A.; Ceranna, L.; Charlton-Perez, A. J.; Ripepe, M.; Evers, L.; Kvaerna, T.; Lastovicka, J.; Eliasson, L.; Crosby, N. B.; Blanc-Benon, P.; Le Pichon, A.; Marchetti, E.; Pilger, C.; Keckhut, P.; Schmidt, C.; Lee, C.; Smets, P.

    2013-12-01

    ARISE proposes to design a new infrastructure that integrates different station networks in order to provide a new "3D" image of the atmospheric dynamics from the ground up to the mesosphere with unprecedented spatio-temporal resolution. These networks are: - the International infrasound network developed for the verification of the Comprehensive nuclear Test Ban Treaty (CTBT). This system is unique by its quality for infrasound and atmospheric wave observations, - the Network for the Detection of Atmospheric Composition Changes (NDACC) which uses Lidar to measure stratospheric dynamics, - the Network for the Detection of Mesopause Changes (NDMC), dedicated to airglow layer measurements in the mesosphere, and additional complementary stations and satellite data. The infrastructure extends across Europe and outlying regions, including polar and equatorial regions. The measurements will be used to improve the parameterization of gravity waves in the stratosphere to better resolve climate models. The project also concerns civil applications related to monitoring of natural hazards as volcanoes. The presentation will highlight the first results obtained in the frame of the project.

  5. Leiomyosarcoma Arising in the Pancreatic Duct: A Case Report and Review of the Current Literature

    Directory of Open Access Journals (Sweden)

    Nicole D. Riddle

    2010-01-01

    Full Text Available Context. Leiomyosarcomas are rare malignant smooth muscle tumors that may arise in any organ or tissue that contains smooth muscle, commonly within the gastrointestinal tract. They are most often found in the stomach, large and small intestines, and retroperitoneum. Primary pancreatic leiomyosarcoma is extremely rare, and to the best of our knowledge only 30 cases have been reported in the world literature since 1951. Our case represents the first to have a clear origin from the main pancreatic duct. Case Report. This case was diagnosed in a large, tertiary care center in Tampa, Florida. Pertinent information was obtained from chart review and interdepartmental collaboration. A mass in the tail of the pancreas was identified with large pleomorphic and spindle-shaped cells. Immunohistochemistry for vimentin, smooth muscle actin, and desmin was positive. All remaining immunohistochemical markers performed were negative. The tumor clearly originated from the pancreatic duct wall, filled and expanded the duct lumen, and was covered with a layer of benign biliary epithelium. Conclusion. Leiomyosarcoma of the pancreas is an extremely rare malignancy with few reported cases in the literature. The prognosis is poor, and treatment consists of alleviating symptoms and pain management. To our knowledge, this represents the first reported case demonstrating clear origin of a leiomyosarcoma from the pancreatic duct.

  6. Representation of discrete Steklov-Poincare operator arising in domain decomposition methods in wavelet basis

    Energy Technology Data Exchange (ETDEWEB)

    Jemcov, A.; Matovic, M.D. [Queen`s Univ., Kingston, Ontario (Canada)

    1996-12-31

    This paper examines the sparse representation and preconditioning of a discrete Steklov-Poincare operator which arises in domain decomposition methods. A non-overlapping domain decomposition method is applied to a second order self-adjoint elliptic operator (Poisson equation), with homogeneous boundary conditions, as a model problem. It is shown that the discrete Steklov-Poincare operator allows sparse representation with a bounded condition number in wavelet basis if the transformation is followed by thresholding and resealing. These two steps combined enable the effective use of Krylov subspace methods as an iterative solution procedure for the system of linear equations. Finding the solution of an interface problem in domain decomposition methods, known as a Schur complement problem, has been shown to be equivalent to the discrete form of Steklov-Poincare operator. A common way to obtain Schur complement matrix is by ordering the matrix of discrete differential operator in subdomain node groups then block eliminating interface nodes. The result is a dense matrix which corresponds to the interface problem. This is equivalent to reducing the original problem to several smaller differential problems and one boundary integral equation problem for the subdomain interface.

  7. Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation.

    Directory of Open Access Journals (Sweden)

    Hsin-Hung Chou

    2009-09-01

    Full Text Available Understanding the evolution of biological systems requires untangling the molecular mechanisms that connect genetic and environmental variations to their physiological consequences. Metal limitation across many environments, ranging from pathogens in the human body to phytoplankton in the oceans, imposes strong selection for improved metal acquisition systems. In this study, we uncovered the genetic and physiological basis of adaptation to metal limitation using experimental populations of Methylobacterium extorquens AM1 evolved in metal-deficient growth media. We identified a transposition mutation arising recurrently in 30 of 32 independent populations that utilized methanol as a carbon source, but not in any of the 8 that utilized only succinate. These parallel insertion events increased expression of a novel transporter system that enhanced cobalt uptake. Such ability ensured the production of vitamin B(12, a cobalt-containing cofactor, to sustain two vitamin B(12-dependent enzymatic reactions essential to methanol, but not succinate, metabolism. Interestingly, this mutation provided higher selective advantages under genetic backgrounds or incubation temperatures that permit faster growth, indicating growth-rate-dependent epistatic and genotype-by-environment interactions. Our results link beneficial mutations emerging in a metal-limiting environment to their physiological basis in carbon metabolism, suggest that certain molecular features may promote the emergence of parallel mutations, and indicate that the selective advantages of some mutations depend generically upon changes in growth rate that can stem from either genetic or environmental influences.

  8. Gliosarcoma arising from oligodendroglioma, IDH mutant and 1p/19q codeleted.

    Science.gov (United States)

    Yasuda, Takayuki; Nitta, Masayuki; Komori, Takashi; Kobayashi, Tatsuya; Masui, Kenta; Maruyama, Takashi; Sawada, Tatsuo; Muragaki, Yoshihiro; Kawamata, Takakazu

    2018-02-01

    Herein, we present a rare case of gliosarcoma arising from oligodendroglioma, isocitrate dehydrogenase (IDH) mutant and 1p/19q codeleted. A 36-year-old man presented with a non-enhanced calcified abnormal lesion on the right frontal lobe. The patient underwent subtotal surgical resection, PAV chemotherapy (procarbazine, nimustine (ACNU) and vincristine), and fractionated radiotherapy with 50 Gy. The pathological diagnosis was oligodendroglioma, IDH mutant and 1p/19q codeleted, World Health Organization 2016 grade II. Six years later, a new enhanced lesion appeared, and the recurrent tumor was surgically removed. Although the histopathological findings indicated gliosarcoma, the recurrent tumor still demonstrated the IDH mutation and 1p/19q codeleted. Thus, the recurrent tumor was considered to originate from oligodendroglioma, rather than being newly generated after chemoradiotherapy. Interestingly, the second recurrent tumor responded well to temozolomide chemotherapy. Based on the findings of this case, oligodendrogliomas have the potential for mesenchymal transformation on progression, while keeping their genotype. © 2017 Japanese Society of Neuropathology.

  9. Excess Magnetic Susceptibility Arising from Self damage in Alpha-Pu

    Science.gov (United States)

    McCall, Scott

    2005-03-01

    The f-electrons of plutonium are delicately poised on the edge between localized and itinerant behavior. In the case of α-Pu, the electrons are nearly localized in a narrow f-band and the Pauli magnetic susceptibility is the largest of any element. Low temperature magnetic susceptibility measurements on α-Pu show that the magnetic susceptibility increases as a function of time, yet upon annealing the specimen at 350K, it returns to its initial value. This suggests that the excess magnetic susceptibility, χxs(t,T), arises from the α-decay and U recoil damage cascades which produce vacancy and interstitials as point and extended defects. The time dependence of χxs is well described by χxs˜a(1-exp(-t/τ)) where a and τ are both functions of temperature. At short times, χxs(Tlaw. However, as t-->∞, χxs(T T-1 implying that self-damage may drive Pu towards non-Fermi liquid behavior. This work was performed under the auspices of the U. S. DOE by Lawrence Livermore National Laboratory, under contract W-7405-Eng-48.

  10. Self-Doping Effect Arising from Electron Correlations in Multilayer Cuprates

    Science.gov (United States)

    Nishiguchi, Kazutaka; Teranishi, Shingo; Kusakabe, Koichi

    2017-08-01

    A self-doping effect between outer and inner CuO2 planes (OPs and IPs) in multilayer cuprate superconductors is studied. When one considers a three-layer tight-binding model of the Hg-based three-layer cuprate derived from first-principles calculations, the electron concentration becomes larger in the OPs than in the IP. This is inconsistent with the experimental finding that more hole carriers tend to be introduced into the OPs than into the IP. We investigate a three-layer Hubbard model with the two-particle self-consistent approach for multilayer systems to incorporate electron correlations. We observe that the double occupancy (antiferromagnetic instability) in the IP decreases (increases) more than that in the OPs, and also reveal that more electrons tend to be introduced into the IP than into the OPs to obtain an energy gain from the on-site Hubbard interaction. These results are consistent with the experimental findings, and this electron distribution between the OPs and IP can be interpreted as a self-doping effect arising from strong electron correlations.

  11. Existence of solutions to boundary value problems arising from the fractional advection dispersion equation

    Directory of Open Access Journals (Sweden)

    Lingju Kong

    2013-04-01

    Full Text Available We study the existence of multiple solutions to the boundary value problem $$displaylines{ frac{d}{dt}Big(frac12{}_0D_t^{-eta}(u'(t+frac12{}_tD_T^{-eta}(u'(t Big+lambda abla F(t,u(t=0,quad tin [0,T],cr u(0=u(T=0, }$$ where $T>0$, $lambda>0$ is a parameter, $0leqeta<1$, ${}_0D_t^{-eta}$ and ${}_tD_T^{-eta}$ are, respectively, the left and right Riemann-Liouville fractional integrals of order $eta$, $F: [0,T]imesmathbb{R}^Nomathbb{R}$ is a given function. Our interest in the above system arises from studying the steady fractional advection dispersion equation. By applying variational methods, we obtain sufficient conditions under which the above equation has at least three solutions. Our results are new even for the special case when $eta=0$. Examples are provided to illustrate the applicability of our results.

  12. Historical aspects of arising and features of activity of startup companies: accounting and economic aspects

    Directory of Open Access Journals (Sweden)

    S.F. Legenchuk

    2016-07-01

    Full Text Available The history of arising and development of the concept of «startup company» have been studied and the importance of their activities have been determined. Using the largest startups (Amazon, Google, Salesforce, VMware, Facebook, Twitter, Groupon, Zynga and Аpple the main components of their activity have been determined. Because of the lack of the scientific literature that directly investigated this topic the approaches of different authors from electronic sources have been systematized and the most used of them have been analyzed. The own vision of the definition of «startup company» and its key features have been formulated as a result of the research. The place of a startup company in the system of economic categories such as an economic activity, results of company activities, accounting, analysis and risks have been determined. The impact of the consequences of risks (positive and negative of economic activity on the future of companies have been considered. The value of accounting and analysis for the economic activity of startup companies have been evaluated.

  13. Self-induced parametric amplification arising from nonlinear elastic coupling in a micromechanical resonating disk gyroscope

    Science.gov (United States)

    Nitzan, Sarah H.; Zega, Valentina; Li, Mo; Ahn, Chae H.; Corigliano, Alberto; Kenny, Thomas W.; Horsley, David A.

    2015-01-01

    Parametric amplification, resulting from intentionally varying a parameter in a resonator at twice its resonant frequency, has been successfully employed to increase the sensitivity of many micro- and nano-scale sensors. Here, we introduce the concept of self-induced parametric amplification, which arises naturally from nonlinear elastic coupling between the degenerate vibration modes in a micromechanical disk-resonator, and is not externally applied. The device functions as a gyroscope wherein angular rotation is detected from Coriolis coupling of elastic vibration energy from a driven vibration mode into a second degenerate sensing mode. While nonlinear elasticity in silicon resonators is extremely weak, in this high quality-factor device, ppm-level nonlinear elastic effects result in an order-of-magnitude increase in the observed sensitivity to Coriolis force relative to linear theory. Perfect degeneracy of the primary and secondary vibration modes is achieved through electrostatic frequency tuning, which also enables the phase and frequency of the parametric coupling to be varied, and we show that the resulting phase and frequency dependence of the amplification follow the theory of parametric resonance. We expect that this phenomenon will be useful for both fundamental studies of dynamic systems with low dissipation and for increasing signal-to-noise ratio in practical applications such as gyroscopes. PMID:25762243

  14. A New Homotopy Perturbation Scheme for Solving Singular Boundary Value Problems Arising in Various Physical Models

    Science.gov (United States)

    Roul, Pradip; Warbhe, Ujwal

    2017-08-01

    The classical homotopy perturbation method proposed by J. H. He, Comput. Methods Appl. Mech. Eng. 178, 257 (1999) is useful for obtaining the approximate solutions for a wide class of nonlinear problems in terms of series with easily calculable components. However, in some cases, it has been found that this method results in slowly convergent series. To overcome the shortcoming, we present a new reliable algorithm called the domain decomposition homotopy perturbation method (DDHPM) to solve a class of singular two-point boundary value problems with Neumann and Robin-type boundary conditions arising in various physical models. Five numerical examples are presented to demonstrate the accuracy and applicability of our method, including thermal explosion, oxygen-diffusion in a spherical cell and heat conduction through a solid with heat generation. A comparison is made between the proposed technique and other existing seminumerical or numerical techniques. Numerical results reveal that only two or three iterations lead to high accuracy of the solution and this newly improved technique introduces a powerful improvement for solving nonlinear singular boundary value problems (SBVPs).

  15. Turing-Hopf instability in biochemical reaction networks arising from pairs of subnetworks.

    Science.gov (United States)

    Mincheva, Maya; Roussel, Marc R

    2012-11-01

    Network conditions for Turing instability in biochemical systems with two biochemical species are well known and involve autocatalysis or self-activation. On the other hand general network conditions for potential Turing instabilities in large biochemical reaction networks are not well developed. A biochemical reaction network with any number of species where only one species moves is represented by a simple digraph and is modeled by a reaction-diffusion system with non-mass action kinetics. A graph-theoretic condition for potential Turing-Hopf instability that arises when a spatially homogeneous equilibrium loses its stability via a single pair of complex eigenvalues is obtained. This novel graph-theoretic condition is closely related to the negative cycle condition for oscillations in ordinary differential equation models and its generalizations, and requires the existence of a pair of subnetworks, each containing an even number of positive cycles. The technique is illustrated with a double-cycle Goodwin type model. Copyright © 2012 Elsevier Inc. All rights reserved.

  16. Ecological Risks in Residential Premises Arising from Thermal Insulation by Pouring

    Science.gov (United States)

    Timofeeva, S. S.; Timofeev, S. S.

    2017-11-01

    The residents of modern megacities are exposed to environmental risks arising both directly in the urban environment and their own dwellings. Modern polymeric building materials are the sources of toxic substances release into the air that have a significant impact on the population health. The objective of the work is the ecological and hygienic study of the air in the apartments of Irkutsk after repair work on the roof and walls insulation using the technology of pouring and calculation of the potential environmental risk for the residents. The object of the research was the indoor air in one of the houses in Irkutsk tested for formaldehyde and other toxic substances. After putting the house into operation, some defects were found - the freezing of the walls of the building attic part. During the repair work, the mansard part of the building was heat-insulated by the pouring method using the composite material “Poroplast CF 02”. High concentrations of formaldehyde and styrene were detected in the apartments exceeding the MPC in 4-8 times. The hazard ratio for inhalation exposure to harmful substances exceeds the safety level by 10 times. Consequently, there is a high probability of obtaining acute and chronic poisoning and developing cancer.

  17. Upper limits on the probability of an interstellar civilization arising in the local Solar neighborhood

    CERN Document Server

    Cartin, Daniel

    2015-01-01

    At this point in time, there is very little empirical evidence on the likelihood of a space-faring species originating in the biosphere of a habitable world. However, there is a tension between the expectation that such a probability is relatively high (given our own origins on Earth), and the lack of any basis for believing the Solar System has ever been visited by an extraterrestrial colonization effort. This paper seeks to place upper limits on the probability of an interstellar civilization arising on a habitable planet in its stellar system, using a percolation model to simulate the progress of such a hypothetical civilization's colonization efforts in the local Solar neighborhood. To be as realistic as possible, the actual physical positions and characteristics of all stars within 40 parsecs of the Solar System are used as possible colony sites in the percolation process. If an interstellar civilization is very likely to have such colonization programs, and they can travel over large distances, then the...

  18. PERSPECTIVES OF SOCIAL INTEGRATION OF WORKERS ARISING FROM BANGLADESH AND SENEGAL IN RONDONENSE COMMUNITY

    Directory of Open Access Journals (Sweden)

    Paulo César da Silva Ilha

    2015-11-01

    Full Text Available This study presents an analysis of how the institutional, organizational and economic environments can influence the social integration of foreign workers in rondonense community. For this, we applied the Prospective Structural Analysis, a method in the form of matrix analysis of relations between the constituent variables of the system studied and those that belong to their explanatory context. The results suggest that there is a strong influence of the institutional and economic environment regarding immigration policies between countries and social integration of immigrants in the host community. There is also an unstable environment displayed by a large number of variables which arise, while also dependent and highly influential. The variable with the most influence, in view of the research group, is the pace of work adopted by agribusinesses. Thus, the institutional environment must be improved and begin the process of improvement, either in the field of migration policies and the development of actions that provides the best quality of life for immigrants and the local community, thus creating an environment of high convergence integration between the local community and the immigrant community. So that significant changes may occur it is necessary, among other things, that the coordination system is driven by institutional bodies represented by the government, with the support of agribusinesses that these immigrants work, developing levers of mutual cooperation between government, industry and immigrants.

  19. Adenocarcinoma arising in a heterotopic pancreas (Heinrich type III: a case report

    Directory of Open Access Journals (Sweden)

    Egashira Yutaro

    2010-02-01

    Full Text Available Abstract Introduction Heterotopic pancreatic cancer in the duodenum is a very rare disease. Only twelve cases have been reported worldwide to date. We report a rare case of malignant transformation of heterotopic pancreas (Heinrich type III in the duodenum with long-term survival of the patient, and review the 12 cases in the literature. Case presentation A 75-year-old Japanese man was admitted to our hospital complaining of nausea and vomiting. Endoscopy and upper gastrointestinal contrast study showed marked duodenal stenosis. A pylorus-preserving pancreaticoduodenectomy was performed. Histopathological examination of the surgically resected specimen showed malignant transformation of heterotopic pancreas (Heinrich type III in the duodenum. The postoperative course was uneventful, and the patient was discharged from the hospital on postoperative day 30. He is well and shows no signs of recurrence at the time of writing, six years after the surgery. Conclusion Adenocarcinoma arising within the heterotopic pancreas appears to be rare. It is difficult to obtain a correct diagnosis preoperatively. The management of heterotopic pancreas depends on the presence or absence of symptoms. If the patient is asymptomatic or benign, conservative treatment with regular follow-up is recommended. When the patient is symptomatic or there is a suspicion of malignancy, surgical management with intra-operative frozen section diagnosis is indicated.

  20. Recovery from impaired muscle growth arises from prolonged postnatal accretion of myonuclei in Atrx mutant mice.

    Science.gov (United States)

    Huh, Michael S; Young, Kevin G; Yan, Keqin; Price-O'Dea, Tina; Picketts, David J

    2017-01-01

    Reduced muscle mass due to pathological development can occur through several mechanisms, including the loss or reduced proliferation of muscle stem cells. Muscle-specific ablation of the α-thalassemia mental retardation syndrome mutant protein, Atrx, in transgenic mice results in animals with a severely reduced muscle mass at three weeks of age; yet this muscle mass reduction resolves by adult age. Here, we explore the cellular mechanism underlying this effect. Analysis of Atrx mutant mice included testing for grip strength and rotorod performance. Muscle fiber length, fiber volume and numbers of myofiber-associated nuclei were determined from individual EDL or soleus myofibers isolated at three, five, or eight weeks. Myofibers from three week old Atrx mutant mice are smaller with fewer myofiber-associated nuclei and reduced volume compared to control animals, despite similar fiber numbers. Nonetheless, the grip strength of Atrx mutant mice was comparable to control mice when adjusted for body weight. Myofiber volume remained smaller at five weeks, becoming comparable to controls by 8 weeks of age. Concomitantly, increased numbers of myofiber-associated nuclei and Ki67+ myoblasts indicated that the recovery of muscle mass likely arises from the prolonged accretion of new myonuclei. This suggests that under disease conditions the muscle satellite stem cell niche can remain in a prolonged active state, allowing for the addition of a minimum number of myonuclei required to achieve a normal muscle size.

  1. The Feasibility and Acceptability of "Arise": An Online Substance Abuse Relapse Prevention Program.

    Science.gov (United States)

    Sanchez, Rebecca Polley; Bartel, Chelsea M

    2015-04-01

    The purpose of this study was to test the feasibility and acceptability of a novel online adolescent substance abuse relapse prevention tool, "Arise" (3C Institute, Cary, NC). The program uses an innovative platform including interactive instructional segments and skill-building games to help adolescents learn and practice coping skills training strategies. We conducted a pilot test with nine adolescents in substance abuse treatment (44 percent female) and a feasibility test with treatment providers (n=8; 50 percent female). Adolescents interacted with the program via a secure Web site for approximately 30 minutes for each of two instructional units. Treatment providers reviewed the same material at their own pace. All participants completed a questionnaire with items assessing usability, acceptability, understanding, and subjective experience of the program. Regarding feasibility, recruitment of this population within the study constraints proved challenging, but participant retention in the trial was high (no attrition). Adolescents and treatment providers completed the program with no reported problems, and overall we were able to collect data as planned. Regarding acceptability, the program received strong ratings from both adolescents and providers, who found the prototype informative, engaging, and appealing. Both groups strongly recommended continuing development. We were able to deliver the intervention as intended, and acceptability ratings were high, demonstrating the feasibility and acceptability of online delivery of engaging interactive interventions. This study contributes to our understanding of how interactive technologies, including games, can be used to modify behavior in substance abuse treatment and other health areas.

  2. A novel HER2-positive breast cancer phenotype arising from germline TP53 mutations.

    Science.gov (United States)

    Wilson, J R F; Bateman, A C; Hanson, H; An, Q; Evans, G; Rahman, N; Jones, J L; Eccles, D M

    2010-11-01

    The Li-Fraumeni Syndrome is caused by a germline TP53 mutation and is associated with a high risk of breast cancer at young ages. Basal (triple negative) breast cancers are now well recognised to be a typical sub-type of breast cancer developing in a large proportion of BRCA1 gene carriers. We considered whether a similar narrow sub-type of breast cancer was found in TP53 gene mutation carriers. A hypothesis generating study to investigate whether there are specific breast tumour characteristics associated with germline TP53 mutations. Pathological characteristics in 12 breast cancers arising in nine patients carrying pathogenic TP53 mutations were compared to a reference panel of 231 young onset breast tumours included in the POSH study. Patients carrying a TP53 mutation showed a significantly higher likelihood of developing a breast cancer with Human Epidermal growth factor Receptor (HER2) amplification (83%) when compared to the cohort of young onset breast cancer cases (16%); ER and PR status were equivalent between groups. These findings suggest that breast cancer developing on a background of an inherited TP53 mutation is highly likely to present with amplification of HER2.

  3. Squamous Cell Carcinoma Arising from an Oral Lichenoid Lesion: A Case Report

    Directory of Open Access Journals (Sweden)

    Ali Taghavi Zenouz

    2012-02-01

    Full Text Available Lichenoid reactions represent a family of lesions with different etiologic factors and a common clinical and histologic appearance. Lichen planus is included with lichenoid reactions and is a relatively common chronic mucocutaneous disorder. The most important complication of lichenoid reactions is the possibility of malignant transformation. That is why it has been considered a precancerous condition. Although the malignant transformation rate varies widely in the literature, from 0.4 to 6.5 percent, in most studies it does not exceed 1%. The aim of this paper is to report a rare case of squamous cell carcinoma (SCC arising within an oral lichenoid lesion in a 17-year-old woman, where SCC is very uncommon. The patient did not have any risk factors and was healthy. The lesion was located on the border of the tongue. In view of the common occurrence of OLP (oral lichen planus and the unresolved issues regarding its premalignant potential, this case report illustrates the need for histologic confirmation and a close follow-up of clinical lesions with lichenoid features.

  4. Reactive eccrine syringofibroadenoma arising in peristomal skin: An unusual presentation of a rare lesion.

    Science.gov (United States)

    Mattoch, Ingerlisa W; Pham, Ngoc; Robbins, Jason B; Bogomilsky, Jodie; Tandon, Meena; Kohler, Sabine

    2008-04-01

    We report the third case of eccrine syringofibroadenoma (ESFA) arising in peristomal skin. A 55-year-old man presented with a 15- x 10-cm pale pink verrucous, exophytic, intermittently tender plaque involving his ileostomy site. He had undergone proctocolectomy with ileostomy creation 33 years prior for ulcerative colitis. The clinical differential diagnosis included granulomatous dermatitis, infection (fungus or atypical mycobacterium), or neoplasm. A punch biopsy specimen was performed and showed ESFA. Although ESFA is considered to be benign, recent reports have demonstrated an association of ESFA with malignancy or malignant transformation of ESFA. Furthermore, ESFA and reported cases of ileostomy carcinoma share similar clinical symptoms at presentation including pain, irritation, ulceration, bleeding, and the presence of a fungating mass. The lesion was, therefore, excised in toto and the excisional specimen showed no evidence of malignancy. We speculate that ESFA is a reaction to chronic irritation and, analogous to other long-standing reactive processes such as lichen sclerosis or burn scar ulcers, may be associated with malignant transformation. Because of this possibility and the clinical overlap with ileostomy carcinoma, peristomal ESFA should be treated with complete excision. If it is not amenable to complete excision because of lesion size or anatomic complexity, generous sampling and close clinical follow-up are recommended.

  5. Squamous Cell Carcinoma Arising from Inverted Schneiderian Papilloma: A Case Report with Oral Involvement

    Directory of Open Access Journals (Sweden)

    Alexandre Simões Garcia

    2014-01-01

    Full Text Available Inverted Schneiderian papilloma is an uncommon benign tumor that presents tendency to recur and propensity to be associated with malignancy in approximately 10% of the cases. Some of these lesions are isolated in the maxillary sinus, and predominantly affect white males with mean age of 50 years. We report a case of squamous cell carcinoma arising from inverted Schneiderian papilloma in the maxillary sinus extending to the mouth. The patient was submitted to extraction of a maxillary molar tooth four months before the exacerbation of the symptoms of nasal airway obstruction and facial enlargement. Computed tomography scan revealed a sinonasal mass causing opacification of the right maxillary sinus with destruction of the lateral nasal wall and maxillary sinus floor. The patient was referred to an oncology center for treatment and died from tumor progression one year after the cancer was diagnosed. The intention of this report is to alert dentists to include the inverted Schneiderian papilloma, either associated with squamous cell carcinoma, or not, in the differential diagnosis of maxillary sinus tumors with aggressive behavior, which may extend to the oral cavity or involve roots of teeth.

  6. Successful ablation of incessant idiopathic right ventricular tachycardia arising from unusual sites in children.

    Science.gov (United States)

    Wu, Lin; Tian, Hong; Wang, Feng; Liang, Xuecun; Chen, Gang

    2016-04-01

    Most idiopathic right ventricular tachycardias originate from the outflow tract. We present a case series of idiopathic incessant ventricular tachycardia arising from unusual sites of the right ventricle in children, which were well resolved by catheter ablation. A retrospective review was performed of all three patients who underwent ablation of idiopathic ventricular tachycardia below the level of the right ventricular outflow tract using three-dimensional mapping in our institute. Result All three patients presented with tachycardia-induced cardiomyopathy due to incessant ventricular tachycardia on first admission. The sites of successful ablation were at the proximal right bundle branch, distal right bundle branch, and apex of the right ventricle, respectively. No complications occurred, and there has been no recurrence of ventricular tachycardia after the final ablation at an average follow-up period of 9 months. All three patients have achieved normalisation of left ventricular size and systolic function. Incessant idiopathic ventricular tachycardia originating from unusual sites of the right ventricle in children, resulting in significant symptoms and impaired ventricular function, can be successfully treated with catheter ablation.

  7. Hiroshima to Fukushima biohazards of radiation

    CERN Document Server

    Ochiai, Eiichiro

    2014-01-01

    Set against a backdrop of the recent disaster at the Fukushima nuclear power plant, "Hiroshima to Fukushima" examines the issue of radiation safety. The author provides important and accurate scientific information about the radioactive substances arising from nuclear power plants and weapons, including the effects of this radiation on living organisms. Currently, humankind is at a crossroads and must decide whether to phase out or increase its reliance on nuclear power as weapons and an energy source. Although a few countries, mostly European, have vowed to abolish nuclear power as an energy source, many other countries are about to increase their nuclear power programs. This book is written from a Japanese perspective and thus provides an alternative to views of Western writers. The author includes rigorous scientific analyses, however maintains a broad scope which allows the book to be accessible to decision-makers and non-specialists.

  8. Disposal of radioactive wastes arising in the United Kingdom from the peaceful uses of atomic energy

    CERN Document Server

    Bryant, P M

    1971-01-01

    This paper describes United Kingdom policy in relation to radioactive waste and summarises the relevant legislation ad methods of control. Data are given on the amounts of radioactivity discharged as waste from establishments of the United Kingdom Atomic Energy Authority, the nuclear power stations operated by the Electricity Generating Boards and other users of radioactive materials. Studies of the behaviour of radioactivity in the environment are reported with particular reference to food chains and other potential sources of irradiation of the public. The results of environmental monitoring are presented and estimates are made of radiation doses received by individual members of the public and larger population groups as a result of waste disposal. It is concluded that the doses received are all within the appropriate limits recommended by the International Commission on Radiological Protection, and in most cases are trivial.

  9. Black-hole horizons in modified spacetime structures arising from canonical quantum gravity

    Energy Technology Data Exchange (ETDEWEB)

    Bojowald, Martin; Paily, George M [Institute for Gravitation and the Cosmos, The Pennsylvania State University, 104 Davey Lab, University Park, PA 16802 (United States); Reyes, Juan D [Instituto de Matematicas, Universidad Nacional Autonoma de Mexico, Campus Morelia, A. Postal 61-3, C.P. 58090, Morelia, Michoacan (Mexico); Tibrewala, Rakesh, E-mail: bojowald@gravity.psu.edu, E-mail: gmpaily@phys.psu.edu, E-mail: jdreyes@matmor.unam.mx, E-mail: rtibs@imsc.res.in [Institute of Mathematical Sciences, CIT Campus, Chennai 600113 (India)

    2011-09-21

    Several properties of canonical quantum gravity modify spacetime structures, sometimes to the degree that no effective line elements exist to describe the geometry. An analysis of solutions, for instance in the context of black holes, then requires new insights. In this paper, standard definitions of horizons in spherical symmetry are first reformulated canonically, and then evaluated for solutions of equations and constraints modified by inverse-triad corrections of loop quantum gravity. When possible, a spacetime analysis is performed which reveals a mass threshold for black holes and small changes to Hawking radiation. For more general conclusions, canonical perturbation theory is developed to second order to include back-reaction from matter. The results shed light on the questions of whether renormalization of Newton's constant or other modifications of horizon conditions should be taken into account in computations of black-hole entropy in loop quantum gravity.

  10. Features of inverse problem arise from structure of a general pure Mueller matrix

    Science.gov (United States)

    Savenkov, Sergey N.; Oberemok, Yevgen A.; Nikonov, Vladimir N.

    2009-08-01

    Changes in the state of polarization of a beam of radiation occurring without depolarization can be described by means of a pure Mueller matrix. Pure Mueller matrix can be expressed in terms of the elements of a 2x2 Jones matrix. This results in that the pure Mueller matrix has a simple and elegant structure, which is embodied by interrelations between matrix elements. All possible interrelations for the elements of a general pure Mueller matrix are derived by Hovenier (Appl. Opt., Vol.33, No.36, pp. 8318-8324, 1994). The structure of the pure Mueller matrix enables to solve the inverse problem basing not on all sixteen matrix elements but only on certain part of them. We show that four elements which are formed each of columns and rows of the pure Mueller matrix considering them individually are dependent and the inverse problem can be solved in general case basing only on the rest of twelve matrix elements.

  11. Spatial structure arising from neighbour-dependent bias in collective cell movement.

    Science.gov (United States)

    Binny, Rachelle N; Haridas, Parvathi; James, Alex; Law, Richard; Simpson, Matthew J; Plank, Michael J

    2016-01-01

    Mathematical models of collective cell movement often neglect the effects of spatial structure, such as clustering, on the population dynamics. Typically, they assume that individuals interact with one another in proportion to their average density (the mean-field assumption) which means that cell-cell interactions occurring over short spatial ranges are not accounted for. However, in vitro cell culture studies have shown that spatial correlations can play an important role in determining collective behaviour. Here, we take a combined experimental and modelling approach to explore how individual-level interactions give rise to spatial structure in a moving cell population. Using imaging data from in vitro experiments, we quantify the extent of spatial structure in a population of 3T3 fibroblast cells. To understand how this spatial structure arises, we develop a lattice-free individual-based model (IBM) and simulate cell movement in two spatial dimensions. Our model allows an individual's direction of movement to be affected by interactions with other cells in its neighbourhood, providing insights into how directional bias generates spatial structure. We consider how this behaviour scales up to the population level by using the IBM to derive a continuum description in terms of the dynamics of spatial moments. In particular, we account for spatial correlations between cells by considering dynamics of the second spatial moment (the average density of pairs of cells). Our numerical results suggest that the moment dynamics description can provide a good approximation to averaged simulation results from the underlying IBM. Using our in vitro data, we estimate parameters for the model and show that it can generate similar spatial structure to that observed in a 3T3 fibroblast cell population.

  12. Therapeutically targeting cyclin D1 in primary tumors arising from loss of Ini1

    Science.gov (United States)

    Smith, Melissa E.; Cimica, Velasco; Chinni, Srinivasa; Jana, Suman; Koba, Wade; Yang, Zhixia; Fine, Eugene; Zagzag, David; Montagna, Cristina; Kalpana, Ganjam V.

    2011-01-01

    Rhabdoid tumors (RTs) are rare, highly aggressive pediatric malignancies with poor prognosis and with no standard or effective treatment strategies. RTs are characterized by biallelic inactivation of the INI1 tumor suppressor gene. INI1 directly represses CCND1 and activates cyclin-dependent kinase (cdk) inhibitors p16Ink4a and p21CIP. RTs are exquisitely dependent on cyclin D1 for genesis and survival. To facilitate translation of unique therapeutic strategies, we have used genetically engineered, Ini1+/− mice for therapeutic testing. We found that PET can be used to noninvasively and accurately detect primary tumors in Ini1+/− mice. In a PET-guided longitudinal study, we found that treating Ini1+/− mice bearing primary tumors with the pan-cdk inhibitor flavopiridol resulted in complete and stable regression of some tumors. Other tumors showed resistance to flavopiridol, and one of the resistant tumors overexpressed cyclin D1, more than flavopiridol-sensitive cells. The concentration of flavopiridol used was not sufficient to down-modulate the high level of cyclin D1 and failed to induce cell death in the resistant cells. Furthermore, FISH and PCR analyses indicated that there is aneuploidy and increased CCND1 copy number in resistant cells. These studies indicate that resistance to flavopiridol may be correlated to elevated cyclin D1 levels. Our studies also indicate that Ini1+/− mice are valuable tools for testing unique therapeutic strategies and for understanding mechanisms of drug resistance in tumors that arise owing to loss of Ini1, which is essential for developing effective treatment strategies against these aggressive tumors. PMID:21173237

  13. [Diagnosis and treatment of the ganglion cysts and synovial cysts arising from the temporomandibular joints].

    Science.gov (United States)

    Meng, Juan-hong; Guo, Chuan-bin; Ma, Xu-chen

    2014-02-18

    To give a reference for the early diagnosis and treatment of the cysts arising from the temporomandibular joint. Nine patients finally diagnosed as temporomandibular joint cysts at the Peking University Hospital of Stomatology from May 1998 to August 2013 were selected and reviewed. Their clinical manifestations, imaging features, diagnoses and differential diagnoses, treatments and follow-ups were summarized and discussed. In the 9 patients, 3 were males and 6 females. Their ages ranged from 33 to 62 years with a median age of 39 years; the course of the disease ranged from 2 weeks to 3 years with a median of 4 months. The image examinations were performed with conventional X-ray examinations in 7 cases, CT scans in 8 cases, MRI in 6 cases and ultrasound in one case. Of the 9 cases, 7 were finally diagnosed as ganglion cyst and 2 as synovial cyst. Ganglion cysts mainly presented as the mass of preauricular area or joint area, with no obvious symptoms or only local discomfort, occasionally with pain. The synovial cysts manifested as the painful swelling of preauricular area and limited mouth-opening, accompanying with occlusal disorders. The treatments included surgical resection in 8 cases, repeated arthrocenteses and lavages in one case. The follow-ups were from 3 months to 9 years, one case with recurrence, and the remaining eight cases without recurrence. MRI examinations are very helpful in the early diagnosis and treatment planning of temporomandibular joint cysts. Surgical resection can have good results. Repeated arthrocenteses and lavages also have a good result, which may be an alternative choice for synovial cyst, but more accumulation of clinical experience is further needed.

  14. Inventory of aquatic contaminant flux arising from historical metal mining in England and Wales.

    Science.gov (United States)

    Mayes, W M; Potter, H A B; Jarvis, A P

    2010-08-01

    The impact of discharges from abandoned metal and ironstone mines has been a much studied form of aquatic pollution in recent decades. Few attempts however, have been made to accurately determine the overall contaminant mass flux arising from abandoned mine sites at scales above catchment level. Such assessments are critical to determine the significance of former mining to national, regional and ultimately global trace metal flux. This paper presents the most comprehensive national survey to date across England and Wales of the total pollution burden discharged at source from abandoned non-coal mine sites. 338 discharges have been identified (from 4923 known abandoned metal mines) and while concurrent flow and contaminant concentration records are only available for around 30% of these, significant quantities of metals (and As) have been quantified to be discharged. A minimum of 193 tonnes of Zn, 18.5 tonnes of Pb, 0.64 tonnes Cd, 19.1 tonnes of Cu, 551 tonnes Fe, 72 tonnes Mn and 5.1 tonnes As are released in water discharges from abandoned non-coal mines to the surface water environment of England and Wales each year. Precautionary extrapolation of mass fluxes based on the frequency distribution of measured concentration and flow data, for discharges with absent data, suggests that the actual total mass flux for these contaminants could be up to 41% higher. The mass flux of Pb released from mines exceeds that of all currently permitted discharges (e.g. active industrial sites and wastewater treatment works) to surface waters across England and Wales, while those of As, Cd and Zn are of a similar magnitude. These data put into context the enduring legacy of historic mining on the water environment, highlighting its significance relative to more highly regulated polluting sites. Comparison of the figures with estimates of global trace metal flux suggests that the national total identified here is significant on a global scale. 2010 Elsevier B.V. All rights

  15. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.

    Science.gov (United States)

    Zhou, Zinan; Tang, Alan T; Wong, Weng-Yew; Bamezai, Sharika; Goddard, Lauren M; Shenkar, Robert; Zhou, Su; Yang, Jisheng; Wright, Alexander C; Foley, Matthew; Arthur, J Simon C; Whitehead, Kevin J; Awad, Issam A; Li, Dean Y; Zheng, Xiangjian; Kahn, Mark L

    2016-04-07

    Cerebral cavernous malformations (CCMs) are common inherited and sporadic vascular malformations that cause strokes and seizures in younger individuals. CCMs arise from endothelial cell loss of KRIT1, CCM2 or PDCD10, non-homologous proteins that form an adaptor complex. How disruption of the CCM complex results in disease remains controversial, with numerous signalling pathways (including Rho, SMAD and Wnt/β-catenin) and processes such as endothelial-mesenchymal transition (EndMT) proposed to have causal roles. CCM2 binds to MEKK3 (refs 7, 8, 9, 10, 11), and we have recently shown that CCM complex regulation of MEKK3 is essential during vertebrate heart development. Here we investigate this mechanism in CCM disease pathogenesis. Using a neonatal mouse model of CCM disease, we show that expression of the MEKK3 target genes Klf2 and Klf4, as well as Rho and ADAMTS protease activity, are increased in the endothelial cells of early CCM lesions. By contrast, we find no evidence of EndMT or increased SMAD or Wnt signalling during early CCM formation. Endothelial-specific loss of Map3k3 (also known as Mekk3), Klf2 or Klf4 markedly prevents lesion formation, reverses the increase in Rho activity, and rescues lethality. Consistent with these findings in mice, we show that endothelial expression of KLF2 and KLF4 is increased in human familial and sporadic CCM lesions, and that a disease-causing human CCM2 mutation abrogates the MEKK3 interaction without affecting CCM complex formation. These studies identify gain of MEKK3 signalling and KLF2/4 function as causal mechanisms for CCM pathogenesis that may be targeted to develop new CCM therapeutics.

  16. Adenocarcinoma arising at a colostomy site with inguinal lymph node metastasis: report of a case.

    Science.gov (United States)

    Iwamoto, Masayoshi; Kawada, Kenji; Hida, Koya; Hasegawa, Suguru; Sakai, Yoshiharu

    2015-02-01

    Inguinal lymph node metastasis from adenocarcinoma arising at a colostomy site is extremely rare, and the significance of surgical resection for metastatic inguinal lymph nodes has not been established. An 82-year-old woman who had undergone abdominoperineal resection 27 years earlier was admitted to our hospital complaining of bleeding from a colostomy. Physical examination revealed that a tumor at the colostomy site directly invaded into the peristomal skin, and that a left inguinal lymph node was firm and swollen. Positron emission tomography/computed tomography scan demonstrated accumulation of (18)F-fluorodeoxy glucose into both the colostomy tumor and the left swollen inguinal lymph node, while there was no evidence of metastasis to liver or lungs. She underwent open left hemicolectomy with wide local resection of the colostomy, and dissection of left inguinal lymph nodes. Histological diagnosis was a moderately differentiated adenocarcinoma that directly invaded into the surrounding skin and metastasized to the left inguinal lymph node. The patient has been followed up for >5 years without any sign of recurrence. In general, inguinal lymph node metastasis from colorectal cancers is regarded as a systemic disease with a poor prognosis, and so systemic chemotherapy and radiotherapy, but not surgical lymph node dissection, are recommended. Considering the lymphatic drainage route in the present case, inguinal lymph node metastasis does not represent a systemic disease but rather a sentinel nodal metastasis from adenocarcinoma at a colostomy site. Surgical dissection of metastatic inguinal lymph nodes should be considered to enable a favorable prognosis in the absence of distant metastasis to other organs. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity

    Science.gov (United States)

    Samuelsson, Anne-Maj S.; Mullier, Amandine; Maicas, Nuria; Oosterhuis, Nynke R.; Eun Bae, Sung; Novoselova, Tatiana V.; Chan, Li F.; Pombo, Joaquim M.; Taylor, Paul D.; Joles, Jaap A.; Coen, Clive W.; Balthasar, Nina; Poston, Lucilla

    2016-01-01

    Melanocortin-4 receptor (Mc4r)–expressing neurons in the autonomic nervous system, particularly in the paraventricular nucleus of the hypothalamus (PVH), play an essential role in blood pressure (BP) control. Mc4r-deficient (Mc4rKO) mice are severely obese but lack obesity-related hypertension; they also show a reduced pressor response to salt loading. We have previously reported that lean juvenile offspring born to diet-induced obese rats (OffOb) exhibit sympathetic-mediated hypertension, and we proposed a role for postnatally raised leptin in its etiology. Here, we test the hypothesis that neonatal hyperleptinemia due to maternal obesity induces persistent changes in the central melanocortin system, thereby contributing to offspring hypertension. Working on the OffOb paradigm in both sexes and using transgenic technology to restore Mc4r in the PVH of Mc4rKO (Mc4rPVH) mice, we have now shown that these mice develop higher BP than Mc4rKO or WT mice. We have also found that experimental hyperleptinemia induced in the neonatal period in Mc4rPVH and WT mice, but not in the Mc4rKO mice, leads to heightened BP and severe renal dysfunction. Thus, Mc4r in the PVH appears to be required for early-life programming of hypertension arising from either maternal obesity or neonatal hyperleptinemia. Early-life exposure of the PVH to maternal obesity through postnatal elevation of leptin may have long-term consequences for cardiovascular health. PMID:27791019

  18. Attenuation of pollution arising from acid mine drainage by a natural wetland on the Witwatersrand

    Directory of Open Access Journals (Sweden)

    Marc S. Humphries

    2017-01-01

    Full Text Available Wetlands are well known to be efficient at sequestering pollutants from contaminated water. We investigated metal accumulation in the peats of the Klip River, a natural wetland that has received contaminated water from gold mining operations in Johannesburg for over 130 years. Previous work conducted in the downstream portion identified the wetland as an important system for sequestering metals. We focused on the upstream section of the wetland, more proximal to the source of acid mine drainage, to provide a better understanding of the pollutant sources and the role of the wetland in pollutant attenuation. Geochemical and mineralogical analyses of peat cores revealed considerable metal enrichments in the peat ash, particularly in Co, Ni, Zn, Pb, Cu and U. Metal concentrations are typically between 4 to 8 times higher than those previously reported for the downstream, more distal portion of the wetland. The distribution of metal accumulation within the peat profiles suggests that contamination arises from a combination of sources and processes. Elevated concentrations in the shallow peat are attributed to the input of contaminated surface water via tributaries that drain the Central Rand Goldfield, whereas enrichments in the deeper peat suggest significant sub-surface inflow of contaminated water through the underlying dolomitic rocks. Metal immobilisation occurs through a combination of mechanisms, which include the precipitation of gypsum, metal sulfides, Fe-Mn oxyhydroxides and phosphates. Our study highlights the environmental and economic importance of natural wetland systems which have the ability to accumulate large quantities of metals and thus remediate polluted waters.

  19. Transition, coexistence, and interaction of vector localized waves arising from higher-order effects

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chong [School of Physics, Northwest University, Xi’an 710069 (China); Yang, Zhan-Ying, E-mail: zyyang@nwu.edu.cn [School of Physics, Northwest University, Xi’an 710069 (China); Zhao, Li-Chen, E-mail: zhaolichen3@163.com [School of Physics, Northwest University, Xi’an 710069 (China); Yang, Wen-Li [Institute of Modern Physics, Northwest University, Xi’an 710069 (China)

    2015-11-15

    We study vector localized waves on continuous wave background with higher-order effects in a two-mode optical fiber. The striking properties of transition, coexistence, and interaction of these localized waves arising from higher-order effects are revealed in combination with corresponding modulation instability (MI) characteristics. It shows that these vector localized wave properties have no analogues in the case without higher-order effects. Specifically, compared to the scalar case, an intriguing transition between bright–dark rogue waves and w-shaped–anti-w-shaped solitons, which occurs as a result of the attenuation of MI growth rate to vanishing in the zero-frequency perturbation region, is exhibited with the relative background frequency. In particular, our results show that the w-shaped–anti-w-shaped solitons can coexist with breathers, coinciding with the MI analysis where the coexistence condition is a mixture of a modulation stability and MI region. It is interesting that their interaction is inelastic and describes a fusion process. In addition, we demonstrate an annihilation phenomenon for the interaction of two w-shaped solitons which is identified essentially as an inelastic collision in this system. -- Highlights: •Vector rogue wave properties induced by higher-order effects are studied. •A transition between vector rogue waves and solitons is obtained. •The link between the transition and modulation instability (MI) is demonstrated. •The coexistence of vector solitons and breathers coincides with the MI features. •An annihilation phenomenon for the vector two w-shaped solitons is presented.

  20. Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia.

    Science.gov (United States)

    Bochtler, Tilmann; Granzow, Martin; Stölzel, Friedrich; Kunz, Christina; Mohr, Brigitte; Kartal-Kaess, Mutlu; Hinderhofer, Katrin; Heilig, Christoph E; Kramer, Michael; Thiede, Christian; Endris, Volker; Kirchner, Martina; Stenzinger, Albrecht; Benner, Axel; Bornhäuser, Martin; Ehninger, Gerhard; Ho, Anthony D; Jauch, Anna; Krämer, Alwin

    2017-03-09

    Metaphase karyotyping is an established diagnostic standard in acute myeloid leukemia (AML) for risk stratification. One of the cytogenetic findings in AML is structurally highly abnormal marker chromosomes. In this study, we have assessed frequency, cytogenetic characteristics, prognostic impact, and underlying biological origin of marker chromosomes. Given their inherent gross structural chromosomal damage, we speculated that they may arise from chromothripsis, a recently described phenomenon of chromosome fragmentation in a single catastrophic event. In 2 large consecutive prospective, randomized, multicenter, intensive chemotherapy trials (AML96, AML2003) from the Study Alliance Leukemia, marker chromosomes were detectable in 165/1026 (16.1%) of aberrant non-core-binding-factor (CBF) karyotype patients. Adverse-risk karyotypes displayed a higher frequency of marker chromosomes (26.5% in adverse-risk, 40.3% in complex aberrant, and 41.2% in abnormality(17p) karyotypes, P chromosomes were associated with a poorer prognosis compared with other non-CBF aberrant karyotypes and led to lower remission rates (complete remission + complete remission with incomplete recovery), inferior event-free survival as well as overall survival in both trials. In multivariate analysis, marker chromosomes independently predicted poor prognosis in the AML96 trial ≤60 years. As detected by array comparative genomic hybridization, about one-third of marker chromosomes (18/49) had arisen from chromothripsis, whereas this phenomenon was virtually undetectable in a control group of marker chromosome-negative complex aberrant karyotypes (1/34). The chromothripsis-positive cases were characterized by a particularly high degree of karyotype complexity, TP53 mutations, and dismal prognosis. In conclusion, marker chromosomes are indicative of chromothripsis and associated with poor prognosis per se and not merely by association with other adverse cytogenetic features. © 2017 by The American

  1. Dynamical adjustments in IAU 2000A nutation series arising from IAU 2006 precession

    Science.gov (United States)

    Escapa, A.; Getino, J.; Ferrándiz, J. M.; Baenas, T.

    2017-08-01

    The adoption of International Astronomical Union (IAU) 2006 precession model, IAU 2006 precession, requires IAU 2000A nutation to be adjusted to ensure compatibility between both theories. This consists of adding small terms to some nutation amplitudes relevant at the microarcsecond level. Those contributions were derived in previously published articles and are incorporated into current astronomical standards. They are due to the estimation process of nutation amplitudes by Very Long Baseline Interferometry (VLBI) and to the changes induced by the J2 rate present in the precession theory. We focus on the second kind of those adjustments, and develop a simple model of the Earth nutation capable of determining all the changes arising in the theoretical construction of the nutation series in a dynamical consistent way. This entails the consideration of three main classes of effects: the J2 rate, the orbital coefficients rate, and the variations induced by the update of some IAU 2006 precession quantities. With this aim, we construct a first order model for the nutations of the angular momentum axis of the non-rigid Earth. Our treatment is based on a Hamiltonian formalism and leads to analytical formulae for the nutation amplitudes in the form of in-phase, out-of-phase, and mixed secular terms. They allow numerical evaluation of the contributions of the former effects. We conclude that the accepted corrections associated with the J2 rate must be supplemented with new, hitherto unconsidered terms of the same order of magnitude, and that these should be incorporated into present standards.

  2. Plutonium radiation surrogate

    Science.gov (United States)

    Frank, Michael I [Dublin, CA

    2010-02-02

    A self-contained source of gamma-ray and neutron radiation suitable for use as a radiation surrogate for weapons-grade plutonium is described. The source generates a radiation spectrum similar to that of weapons-grade plutonium at 5% energy resolution between 59 and 2614 keV, but contains no special nuclear material and emits little .alpha.-particle radiation. The weapons-grade plutonium radiation surrogate also emits neutrons having fluxes commensurate with the gamma-radiation intensities employed.

  3. Hawking radiation, the Stefan–Boltzmann law, and unitarization

    Energy Technology Data Exchange (ETDEWEB)

    Giddings, Steven B., E-mail: giddings@physics.ucsb.edu

    2016-03-10

    Where does Hawking radiation originate? A common picture is that it arises from excitations very near or at the horizon, and this viewpoint has supported the “firewall” argument and arguments for a key role for the UV-dependent entanglement entropy in describing the quantum mechanics of black holes. However, closer investigation of both the total emission rate and the stress tensor of Hawking radiation supports the statement that its source is a near-horizon quantum region, or “atmosphere,” whose radial extent is set by the horizon radius scale. This is potentially important, since Hawking radiation needs to be modified to restore unitarity, and a natural assumption is that the scales relevant to such modifications are comparable to those governing the Hawking radiation. Moreover, related discussion suggests a resolution to questions regarding extra energy flux in “nonviolent” scenarios, that does not spoil black hole thermodynamics as governed by the Bekenstein–Hawking entropy.

  4. Radiation Safety Awareness among Radiation Workers and ...

    African Journals Online (AJOL)

    Background: All x-ray utilization in human medicine leads to exposure of the patient and personnel to radiation. Although the quantity is low in diagnostic examinations, special attention should be given to this fact in order to minimize unnecessary exposure for both groups. Exposure to ionizing radiation cannot be avoided ...

  5. Transition radiation from graphene plasmons by a bunch beam in the terahertz regime.

    Science.gov (United States)

    Zhang, Kai-Chun; Chen, Xiao-Xing; Sheng, Chang-Jian; Ooi, Kelvin J A; Ang, Lay Kee; Yuan, Xue-Song

    2017-08-21

    The terahertz band is an increasingly important spectrum in a wide range of applications from bioimaging and medical diagnostics to security and wireless communications. We propose a tunable terahertz coherent radiation source based on graphene plasmon-induced transition radiation. The transition radiation in terahertz regime arises from the graphene plasmons, which are excited by a normally incident bunched electron beam. We analyze the field-intensities and spectral-angular distributions of the transition radiation with respect to Fermi energy, substrate dielectric permittivity, and electron bunch energy for both the coherent and incoherent radiation. The effect of electron bunching on the radiation pattern is discussed. The mechanism of plasmon frequency-selective transition radiation is discovered.

  6. Critical behavior of nanoemitter radiation in a percolation material

    Energy Technology Data Exchange (ETDEWEB)

    Burlak, G. [Centro de Investigacion en Ingenieria y Ciencias Aplicadas (Mexico)], E-mail: gburlak@uaem.mx; Diaz-de-Anda, A. [Centro de Investigacion en Ingenieria y Ciencias Aplicadas (Mexico); Karlovich, Yu. [Facultad de Ciencias, Universidad Autonoma del Estado de Morelos, Cuernavaca, Mor. Mexico (Mexico); Klimov, A.B. [Departamento de Fisica, Universidad de Guadalajara, Revolucion 1500, Guadalajara, Jalisco 44420 (Mexico)

    2009-04-06

    We studied the field radiation of disordered optical nanoemitters incorporated into three-dimensional (3D) spanning cluster in a percolation material. In supercritical state, the field intensity is large enough to produce a dynamic high-density coherent field. The resulting state becomes different for lossless and lossy mediums. For material with small losses the long-term coherence arises in the supercritical area close to the percolation threshold. As a result, the dynamic non-monotonic behavior of the field order parameter raises that allows to reach the optimal field intensity. This effect can allow optimization of the disordered optical nanostructures with incorporated radiating nanoemitters in various applications of information technology.

  7. Radiative Heat Transfer Between Core-Shell Nanoparticles

    OpenAIRE

    Nikbakht, Moladad

    2017-01-01

    Radiative heat transfer in systems with core-shell nanoparticles may exhibit not only a combination of disparate physical properties of its components but also further enhanced properties that arise from the synergistic properties of the core and shell components. We study the thermal conductance between two core-shell nanoparticles (CSNPs). We predict that the radiative heat transfer in a dimer of Au@SiO$_2$ CSNPs (i.e., silica-coated gold nanoparticles) could be enhanced several order of ma...

  8. A case of clear cell adenocarcinoma arising from the urethral diverticulum: Utility of urinary cytology and immunohistochemistry

    Directory of Open Access Journals (Sweden)

    Shin-ichi Nakatsuka

    2012-01-01

    Full Text Available Carcinomas rarely arise from the urethral diverticulum. In this report, we present a case of clear cell adenocarcinoma arising from the urethral diverticulum. A 42-year-old woman complained of bloody discharge and lower back pain. Imaging studies showed a tumor involving the region surrounding the urethra and cystourethroscopy showed papillary and villous tumors in the urethral diverticula. Cytology of the urine sediment showed papillary or spherical clusters of atypical cells, some of which had clear abundant cytoplasm and formed mirror ball-like clusters, suggesting adenocarcinoma. Although histological diagnosis was indeterminate by biopsy and transurethral resection (TUR because of absence of stromal invasion, surgically resected specimen via cysturethrectomy revealed that the tumor was clear cell carcinoma. Urinary cytological findings and immunohistochemical analysis for CD15, Ki-67, and p53 might be useful for accurate diagnosis of clear cell adenocarcinoma that arises from the urethral diverticulum when sufficient materials are not available by biopsy and TUR.

  9. Radiation by the numbers: developing an on-line Canadian radiation dose calculator as a public engagement and education tool

    Energy Technology Data Exchange (ETDEWEB)

    Dalzell, M.T.J. [Sylvia Fedoruk Canadian Centre for Nuclear Innovation, Saskatoon, Saskatchewan (Canada)

    2016-06-15

    Concerns arising from misunderstandings about radiation are often cited as a main reason for public antipathy towards nuclear development and impede decision-making by governments and individuals. A lack of information about everyday sources of radiation exposure that is accessible, relatable and factual contributes to the problem. As part of its efforts to be a fact-based source of information on nuclear issues, the Sylvia Fedoruk Canadian Centre for Nuclear Innovation has developed an on-line Canadian Radiation Dose Calculator as a tool to provide context about common sources of radiation. This paper discusses the development of the calculator and describes how the Fedoruk Centre is using it and other tools to support public engagement on nuclear topics. (author)

  10. Hendee's radiation therapy physics

    CERN Document Server

    Pawlicki, Todd; Starkschall, George

    2016-01-01

    The publication of this fourth edition, more than ten years on from the publication of Radiation Therapy Physics third edition, provides a comprehensive and valuable update to the educational offerings in this field. Led by a new team of highly esteemed authors, building on Dr Hendee’s tradition, Hendee’s Radiation Therapy Physics offers a succinctly written, fully modernised update. Radiation physics has undergone many changes in the past ten years: intensity-modulated radiation therapy (IMRT) has become a routine method of radiation treatment delivery, digital imaging has replaced film-screen imaging for localization and verification, image-guided radiation therapy (IGRT) is frequently used, in many centers proton therapy has become a viable mode of radiation therapy, new approaches have been introduced to radiation therapy quality assurance and safety that focus more on process analysis rather than specific performance testing, and the explosion in patient-and machine-related data has necessitated an ...

  11. Fluorescent radiation converter

    Science.gov (United States)

    Viehmann, W. (Inventor)

    1981-01-01

    A fluorescence radiation converter is described which includes a substantially undoped optically transparent substrate and a waveshifter coating deposited on at least one portion of the substrate for absorption of radiation and conversion of fluorescent radiation. The coating is formed to substantially 1000 g/liter of a solvent, 70 to 200 g/liter of an organic polymer, and 0.2 to 25 g/liter of at least one organic fluorescent dye. The incoming incident radiation impinges on the coating. Radiation is absorbed by the fluorescent dye and is re-emitted as a longer wavelength radiation. Radiation is trapped within the substrate and is totally internally reflected by the boundary surface. Emitted radiation leaves the substrate ends to be detected.

  12. Cell Radiation Experiment System

    Science.gov (United States)

    Morrison, Dennis R.

    2010-01-01

    The cell radiation experiment system (CRES) is a perfused-cell culture apparatus, within which cells from humans or other animals can (1) be maintained in homeostasis while (2) being exposed to ionizing radiation during controlled intervals and (3) being monitored to determine the effects of radiation and the repair of radiation damage. The CRES can be used, for example, to determine effects of drug, radiation, and combined drug and radiation treatments on both normal and tumor cells. The CRES can also be used to analyze the effects of radiosensitive or radioprotectant drugs on cells subjected to radiation. The knowledge gained by use of the CRES is expected to contribute to the development of better cancer treatments and of better protection for astronauts, medical-equipment operators, and nuclear-power-plant workers, and others exposed frequently to ionizing radiation.

  13. Environmental Radiation Data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Environmental Radiation Data (ERD) is an electronic and print journal compiled and distributed quarterly by the Office of Radiation and Indoor Air's National Air and...

  14. Radiation processing in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Makuuchi, Keizo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    2001-03-01

    Economic scale of radiation application in the field of industry, agriculture and medicine in Japan in 1997 was investigated to compare its economic impacts with that of nuclear energy industry. Total production value of radiation application accounted for 54% of nuclear industry including nuclear energy industry and radiation applications in three fields above. Industrial radiation applications were further divided into five groups, namely nondestructive test, RI instruments, radiation facilities, radiation processing and ion beam processing. More than 70% of the total production value was brought about by ion beam processing for use with IC and semiconductors. Future economic prospect of radiation processing of polymers, for example cross-linking, EB curing, graft polymerization and degradation, is reviewed. Particular attention was paid to radiation vulcanization of natural rubber latex and also to degradation of natural polymers. (S. Ohno)

  15. Radiation Protection Handbook

    Science.gov (United States)

    1972-01-01

    A handbook which sets forth the Kennedy Space Center radiation protection policy is presented. The book also covers administrative direction and guidance on organizational and procedural requirements of the program. Only ionizing radiation is covered.

  16. Breast radiation - discharge

    Science.gov (United States)

    Radiation - breast - discharge ... You may notice changes in the way your breast looks or feels (if you are getting radiation ... after treatment is over. The skin on your breast may become more sensitive or numb. Skin and ...

  17. ERLN Radiation Focus Area

    Science.gov (United States)

    As part of the Environmental Response Laboratory Network, the National Air and Radiation Environmental Laboratory (NAREL) here provides your laboratory with access to radiation-specific laboratory guidance documents and training courses.

  18. Radiation and Pregnancy

    Science.gov (United States)

    ... Global Map Premature Birth Report Cards Careers Archives Pregnancy Before or between pregnancies Nutrition, weight & fitness Prenatal ... Is it safe? > Radiation and pregnancy Radiation and pregnancy E-mail to a friend Please fill in ...

  19. Radiation therapy -- skin care

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000735.htm Radiation therapy - skin care To use the sharing features ... this page, please enable JavaScript. When you have radiation treatment for cancer, you may have some changes ...

  20. Euler equations on finite-dimensional Lie coalgebras, arising in problems of mathematical physics

    Science.gov (United States)

    Bogoyavlenskii, O. I.

    1992-02-01

    CONTENTSIntroductionChapter I. Euler equations on finite-dimensional Lie coalgebras, arising in physical problems §1. Classical investigations of the Euler equations of the rotation of an n-dimensional rigid body §2. Euler equations on Lie coalgebras, connected with the dynamics of a rigidbody around a fixed point and with the dynamics of a rigid body in an ideal incompressible fluid §3. Algebraic and Hamiltonian structure of the equations of rotation of a satellite around the mass centre §4. Physical applications of Euler equations on the direct sum of n Lie coalgebras SO(3)Chapter II. Integration of the dynamics of an arbitrary rigid body in the Newtonian gravitational field with an arbitrary quadratic potential §1. History of the problem §2. Integrability in the Liouville sense of the equations of rotation of a rigid body around a fixed mass centre in the field of remote attractive objects §3. Integrability in the Liouville sense of the equations of the translational-rotational dynamics of a rigid body in the Newtonian gravitational field with an arbitrary quadratic potential §4. The integrability of the dynamics in terms of Riemann theta-functions §5. Dynamics of a symmetric rigid body in the Newtonian gravitational field with an arbitrary quadratic potential §6. Integrable cases of equations of rotation of a rigid body in non-linear gravitational fields §7. Integrability of the n-dimensional analogue of the problem of rotation of a rigid body in the Newtonian gravitational field with an arbitrary quadratic potential §8. Lagrangian structure of the Kirchhoff equationsChapter III. General integrable problems of classical mechanics §1. Introduction and summary §2. Complete integrability of the dynamics of a C1-central configuration §3. General integrable problems of classical mechanics §4. Hidden symmetry of the inertial dynamics §5. Reductions and integrable cases of rotation of a Ck-central configuration around a fixed point in Newtonian

  1. Radiation effects in semiconductors

    CERN Document Server

    2011-01-01

    There is a need to understand and combat potential radiation damage problems in semiconductor devices and circuits. Written by international experts, this book explains the effects of radiation on semiconductor devices, radiation detectors, and electronic devices and components. These contributors explore emerging applications, detector technologies, circuit design techniques, new materials, and innovative system approaches. The text focuses on how the technology is being used rather than the mathematical foundations behind it. It covers CMOS radiation-tolerant circuit implementations, CMOS pr

  2. Heart and radiation

    Directory of Open Access Journals (Sweden)

    Lauro Martins Júnior

    2011-12-01

    Full Text Available ABSTRATC The heart exposition to ionizing radiation may produce lesions in cardiac structures, acute (in most of cases benign and reversible, or months and even years later. There is a direct relationship of severity of lesions with radiation doses. The clinical picture receives a new denomination: radiation induced cardiopathy. The more frequent use of radiation in diagnosis and therapeutics increases the importance of their knowledge and especially their prevention.

  3. External radiation surveillance

    Energy Technology Data Exchange (ETDEWEB)

    Antonio, E.J.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report describes how external radiation was measured, how surveys were performed, and the results of these measurements and surveys. External radiation exposure rates were measured at locations on and off the Hanford Site using thermoluminescent dosimeters (TLD). External radiation and contamination surveys were also performed with portable radiation survey instruments at locations on and around the Hanford Site.

  4. Synchrotron radiation facilities

    CERN Multimedia

    1972-01-01

    Particularly in the past few years, interest in using the synchrotron radiation emanating from high energy, circular electron machines has grown considerably. In our February issue we included an article on the synchrotron radiation facility at Frascati. This month we are spreading the net wider — saying something about the properties of the radiation, listing the centres where synchrotron radiation facilities exist, adding a brief description of three of them and mentioning areas of physics in which the facilities are used.

  5. Glomus-like bodies within a neurofibroma: a novel neoplasm arising in neurofibromatosis type 1 or a coincidence?

    Science.gov (United States)

    Thareja, Sumeet; Honigbaum, Alexis; Jukic, Drazen

    2015-04-01

    Neurofibromatosis type 1 is a relatively common genetic disorder with variable phenotypes. Tumors with features of both glomus tumors and neurofibromas are exceedingly rare in literature. Herein, we report a not yet described neoplasm with features of both a glomangioma/glomus tumor and a neurofibroma arising in a patient with segmental neurofibromatosis. Our case report supports the theory of a common lineage/ancestor cell between neurofibromas and glomus tumors and adds it to the spectrum of neoplasms that may arise in the setting of Von Recklinghausen's disease. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Radiation bioengineering; Bioinzynieria radiacyjna

    Energy Technology Data Exchange (ETDEWEB)

    Rosiak, J.M. [Politechnika Lodzka, Lodz (Poland). Inst. Techniki Radiacynej

    1997-10-01

    Radiation processing for modification of different properties of materials being designed for medical use have been described. Especially the polymers as very often used for medical equipment production have been modified by radiation. The different medical applications of biomaterials based on radiation modified polymers have been presented. 13 refs.

  7. Ultraviolet radiation and immunosuppression.

    LENUS (Irish Health Repository)

    Murphy, G M

    2009-11-01

    Ultraviolet (UV) radiation is a complete carcinogen. The effects of UV radiation are mediated via direct damage to cellular DNA in the skin and suppression of image surveillance mechanisms. In the context of organ transplantation, addiction of drugs which suppress the immune system add greatly to the carcinogenicity of UV radiation. This review considers the mechanisms of such effects.

  8. (Mis)Understanding Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Schreiber, Stephen Bruce [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-02-10

    This set of slides discusses radiation and fears concerning it at a non-technical level. Included are some misconceptions and practical consequences resulting from these. The concept of radiation hormesis is explained. The author concludes that a number of significant societal benefits are being foregone because of overly cautious concerns about low-level radiation.

  9. RADIATION AND SURGERY

    African Journals Online (AJOL)

    Dr. S.A. Adewuyi

    Introduction. Radiation therapy is devoted to management of patients with cancers and occasionally benign conditions by ionizing radiations. It can be used alone or in combination with other treatment modalities like surgery, chemotherapy, hormonal therapy and immunotherapy . Ionizing radiations were discovered.

  10. Pelvic (between the hips) radiation - discharge

    Science.gov (United States)

    ... radiation treatment area on your body is large. Alternative Names Radiation of the pelvis - discharge; Cancer treatment - pelvic radiation; Prostate cancer - pelvic radiation; Ovarian cancer - pelvic radiation; Cervical ...

  11. Extranodal B Cell Lymphoma with Prominent Spindle Cell Features Arising in Uterus and in Maxillary Sinus: Report of Two Cases and Literature Review.

    Science.gov (United States)

    Li, Yiting; Cui, Wei; Woodroof, Janet M; Zhang, Da

    2016-01-01

    Primary B-cell lymphoma exhibiting a spindle dominant pattern is extremely rare and represents a potential diagnostic pitfall. Here we report two cases of extranodal B cell lymphoma with spindle cell dominant morphology (sp-BCL) of uterus and maxillary sinus. Case 1 was a 54-year-old female with a large mass in the lower uterine segment, inseparable from the wall of the rectum and the urinary bladder. This is the first report of primary sp-BCL arising in the lower uterine segment. Case 2 was a 54-year-old male with a permeative mass involving the maxillary sinus wall with extension into the premaxillary soft tissues. Biopsies of both cases revealed a diffuse infiltration by medium to large atypical spindle cells. A panel of immunohistochemical stains was performed to rule out the possibilities of sarcoma, carcinoma, or melanoma. The final diagnosis was diffuse large B cell lymphoma, germinal center type. This is the first report of sp-BCL incorporating molecular genetic studies and the next-generation sequencing analysis performed on the maxillary lymphoma revealed three genomic alterations in genes of EZH2 (Y646N), IRF8 (S55A), and TNFRSF14 (splice site 304+2T>C). These genes were reported to play important roles in the pathogenesis of diffuse large B cell lymphoma. Both patients achieved complete remission after excision and chemo-radiation therapy despite the extensive local involvement. © 2016 by the Association of Clinical Scientists, Inc.

  12. Topics in radiation dosimetry radiation dosimetry

    CERN Document Server

    1972-01-01

    Radiation Dosimetry, Supplement 1: Topics in Radiation Dosimetry covers instruments and techniques in dealing with special dosimetry problems. The book discusses thermoluminescence dosimetry in archeological dating; dosimetric applications of track etching; vacuum chambers of radiation measurement. The text also describes wall-less detectors in microdosimetry; dosimetry of low-energy X-rays; and the theory and general applicability of the gamma-ray theory of track effects to various systems. Dose equivalent determinations in neutron fields by means of moderator techniques; as well as developm

  13. Radiative Corrections to Bremsstrahlung in Radiative Return

    CERN Document Server

    Yost, S A; Ward, B F L; Yost, Scott A.

    2005-01-01

    Radiating a photon from the initial state provides a useful tool for studying a range of low energy physics using a high-energy e+ e- accelerator. Accurate results require careful calculation of the first order virtual photon corrections. We compare exact results for initial state radiative corrections, finding agreement to an order of 10^{-5} or better as a fraction of the Born cross-section for most of the range of photon energies, at CMS energies relevant in both high-energy collision and radiative return experiments.

  14. Monitoring of radiation exposure

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-02-01

    The guide specifies the requirements for the monitoring of radiation exposure in instances where radiation is used. In addition to workers, the guide covers students, apprentices and visitors. The guide shall also apply to exposure from natural radiation. However, the monitoring of radiation exposure in nuclear power plants is dealt with in YVL Guide 7.10 and 7.11. The guide defines the concepts relevant to the monitoring of radiation exposure and provides guidelines for determining the necessity of monitoring and subsequently arranging such in different operations. In addition, the guide specifies the criteria for the approval and regulatory control of the dosimetric service.

  15. The Solution of Fourth Order Boundary Value Problem Arising out of the Beam-Column Theory Using Adomian Decomposition Method

    Directory of Open Access Journals (Sweden)

    Omer Kelesoglu

    2014-01-01

    Full Text Available Adomian decomposition method (ADM is applied to linear nonhomogeneous boundary value problem arising from the beam-column theory. The obtained results are expressed in tables and graphs. We obtain rapidly converging results to exact solution by using the ADM. This situation indicates that the method is appropriate and reliable for such problems.

  16. A Multi-Depot Two-Echelon Vehicle Routing Problem with Delivery Options Arising in the Last Mile Distribution

    NARCIS (Netherlands)

    Zhou, Lin; Baldacci, Roberto; Vigo, Daniele; Wang, Xu

    2018-01-01

    In this paper, we introduce a new city logistics problem arising in the last mile distribution of e-commerce. The problem involves two levels of routing problems. The first requires a design of the routes for a vehicle fleet located at the depots to transport the customer demands to a subset of the

  17. Towards smart grids: Identifying the risks that arise from the integration of energy and transport supply chains

    NARCIS (Netherlands)

    Eising, J.W.; van Ona, T.; Alkemade, F.

    2014-01-01

    This paper identifies the risks for the functionality and reliability of the grid that arise from the integration of the transport and supply chain. The electrification of transport is a promising option for the transition to a low carbon energy and transport system. But on the short term, the

  18. Effect of Students' Term and Educational Institution on the Arising of Indonesian Morphology-Syntactical Interference in ELLT

    Science.gov (United States)

    Nurhayati, Dwi Astuti Wahyu; Djatmika; Santosa, Riyadi; Wiratno, Tri

    2017-01-01

    This research examines the two factors which effect on the raising of Indonesian morphology-syntactical interference. It aimed at delineating the potential effect of these two factors on the arising of Indonesian morphology-syntactical interference of undergraduate students majoring in English department of State Islamic Institute of Tulungagung…

  19. A short remark on the integrability of a nonlinear reaction-diffusion equation arising in mathematical biology: Compatibility analysis

    Science.gov (United States)

    Aziz, Taha; Fatima, Aeeman; Khalique, Chaudry Masood

    An analytical approach based on the compatibility concept is employed to solve a nonlinear reaction-diffusion model arising in mathematical biology. The solution process makes it extremely easy to obtain a relatively accurate closed-form solution of the model. The pencil-and-paper solution procedure can be extended to other class of nonlinear problems of similar kind.

  20. Local Fractional Fourier Series Solutions for Nonhomogeneous Heat Equations Arising in Fractal Heat Flow with Local Fractional Derivative

    Directory of Open Access Journals (Sweden)

    Ai-Min Yang

    2014-03-01

    Full Text Available The fractal heat flow within local fractional derivative is investigated. The nonhomogeneous heat equations arising in fractal heat flow are discussed. The local fractional Fourier series solutions for one-dimensional nonhomogeneous heat equations are obtained. The nondifferentiable series solutions are given to show the efficiency and implementation of the present method.

  1. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst - a clinicopathologic analysis of 116 reported cases

    NARCIS (Netherlands)

    Bodner, L.; Manor, E.; Shear, M.; van der Waal, I.

    2011-01-01

    Purpose: To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic cyst. Methods: All well-documented cases of PIOSCC published between 1938 and 2010 were collected. Only cases of PIOSCC arising from the lining of an odontogenic cyst, including the

  2. Squamous cell carcinoma arising in a giant epidermal cyst of the perineum: a case report and literature review.

    Science.gov (United States)

    Sumi, Yuki; Yamamoto, Naoto; Kiyosawa, Tomoharu

    2012-09-01

    This case pertains to a 76-year-old woman with a giant cyst in the perineum. Extirpation was performed. The result of a pathological investigation was squamous cell carcinoma arising in an epidermal cyst. An epidermal cyst is necessary to conduct an examination bearing in mind the possibility of a malignant tumour.

  3. COHERENCE PROPERTIES OF ELECTROMAGNETIC RADIATION,

    Science.gov (United States)

    ELECTROMAGNETIC RADIATION , COHERENT SCATTERING), (*COHERENT SCATTERING, ELECTROMAGNETIC RADIATION ), LIGHT, INTERFERENCE, INTENSITY, STATISTICAL FUNCTIONS, QUANTUM THEORY, BOSONS, INTERFEROMETERS, CHINA

  4. Biological improvement of radiation resistance

    Energy Technology Data Exchange (ETDEWEB)

    Chun, K. J.; Lee, Y. K.; Kim, J. S.; Kim, J. K.; Lee, S. J

    2000-08-01

    To investigate the mechanisms of gene action related to the radiation resistance in microorganisms could be essentially helpful for the development of radiation protectants and hormeric effects of low dose radiation. This book described isolation of radiation-resistant microorganisms, induction of radiation-resistant and functionally improved mutants by gamma-ray radiation, cloning and analysis of the radiation resistance related genes and analysis of the expressed proteins of the radiation resistant related genes.

  5. Radiation protection and instrumentation

    Science.gov (United States)

    Bailey, J. V.

    1975-01-01

    Radiation was found not to be an operational problem during the Apollo program. Doses received by the crewmen of Apollo missions 7 through 17 were small because no major solar-particle events occurred during those missions. One small event was detected by a radiation sensor outside the Apollo 12 spacecraft, but no increase in radiation dose to the crewmen inside the spacecraft was detected. Radiation protection for the Apollo program was focused on both the peculiarities of the natural space radiation environment and the increased prevalence of manmade radiation sources on the ground and onboard the spacecraft. Radiation-exposure risks to crewmen were assessed and balanced against mission gain to determine mission constraints. Operational radiation evaluation required specially designed radiation detection systems onboard the spacecraft in addition to the use of satellite data, solar observatory support, and other liaison. Control and management of radioactive sources and radiation-generating equipment was important in minimizing radiation exposure of ground-support personnel, researchers, and the Apollo flight and backup crewmen.

  6. Thermal radiation heat transfer

    CERN Document Server

    Howell, John R; Mengüç, M Pinar

    2011-01-01

    Providing a comprehensive overview of the radiative behavior and properties of materials, the fifth edition of this classic textbook describes the physics of radiative heat transfer, development of relevant analysis methods, and associated mathematical and numerical techniques. Retaining the salient features and fundamental coverage that have made it popular, Thermal Radiation Heat Transfer, Fifth Edition has been carefully streamlined to omit superfluous material, yet enhanced to update information with extensive references. Includes four new chapters on Inverse Methods, Electromagnetic Theory, Scattering and Absorption by Particles, and Near-Field Radiative Transfer Keeping pace with significant developments, this book begins by addressing the radiative properties of blackbody and opaque materials, and how they are predicted using electromagnetic theory and obtained through measurements. It discusses radiative exchange in enclosures without any radiating medium between the surfaces-and where heat conduction...

  7. [Radiation protection in orthopaedics: implications for clinical practice of the new regulations governing roentgen ray irradiation and radioprotection].

    Science.gov (United States)

    Nestle, U; Berlich, J

    2006-05-01

    In 2001 or 2002, the legislator made substantial alterations to the "Röntgenverordnung" [regulations governing use of roentgen ray radiation] and "Strahlenschutzverordnung" [regulations governing radiation protection]. This was done to bring German law in line with EU Directives 96/29/Euratom (basic safety standards for the protection of the health of workers and the general public against the dangers arising from ionizing radiation) and 97/43/Euratom (health protection of individuals against the dangers of ionizing radiation in relation to medical exposure). Proper use of radiation in medicine requires that those involved in its application are aware of the biological effects of radiation. When staff and others are protected good organization and appropriate technology at the workplace can achieve a great deal. In the new directives, the radiation protection for the patient is quantified and the responsibility of the physician is clearly pointed out. The most important aim is uniform quality throughout Europe in radiological diagnosis and radiation protection.

  8. Radiation shield for operator under radiation circumference

    Energy Technology Data Exchange (ETDEWEB)

    Nemezawa, Isao; Kimura, Tadahiro [Hitachi Ltd., Tokyo (Japan); Omori, Tetsu; Mizuochi, Akira

    1997-11-18

    A radiation shield for an upper half of a man`s body comprises a synthetic resin clothing, a rubber plate or a composite member of them formed into a bag. The bag is formed three dimensionally in the form of an open in front vest. A radiation shielding bag for the lower half of a man`s body is formed into three dimensionally in the form of open in front half trousers. A water injection port for injecting water as shielding liquid and a gas exhaust port are formed to each of the bags. Upon operation under radiation circumstance, the water injection ports and the gas exhaustion ports are opened, and shielding liquid is injected from the water injection ports to the bag so that the shielding liquid shields radiation rays. After closing the water injection ports and the gas exhaustion ports, an operator wears and buttons up the radiation shield of the upper half and the lower half to protect radiation exposure from the front, back and the side of a man. (I.N.)

  9. Radiation resistance of wide-gap materials as exemplified by SiC nuclear radiation detectors

    Science.gov (United States)

    Ivanov, A. M.; Strokan, N. B.; Lebedev, A. A.

    2012-04-01

    In wide-gap materials used in nuclear detectors, the polarization effect is typically observed when the concentration of radiation-induced defects is high. An emf arising in the detector is associated with long-term trapping of charge carries by deep radiation-induced levels (centers). The polarization kinetics and the polarization field strength are determined experimentally. The trapping efficiency can be controlled by varying the temperature, and a tradeoff can be reached at an "optimal" temperature between the generation current and the position of the deepest level, which has a negligible effect on charge losses via trapping. It is found that the ratio between the depth of this level and the bandgap is about 1/3 irrespective of the material but the optimal temperature is material-specific.

  10. High Energy/LET Radiation EEE Parts Certification Handbook

    Science.gov (United States)

    Reddell, Brandon

    2012-01-01

    Certifying electronic components is a very involved process. It includes pre-coordination with the radiation test facility for time, schedule and cost, as well as intimate work with designers to develop test procedures and hardware. It also involves work with radiation engineers to understand the effects of the radiation field on the test article/setup as well as the analysis and production of a test report. The technical content of traditional ionizing radiation testing protocol is in wide use and generally follows established standards (ref. Appendix C). This document is not intended to cover all these areas but to cover the methodology of using Variable Depth Bragg Peak (VDBP) to accomplish the goal of characterizing an electronic component. The Variable Depth Bragg Peak (VDBP) test method is primarily used for deep space applications of electronics. However, it can be used on any part for any radiation environment, especially those parts where the sensitive volume cannot be reached by the radiation beam. An example of this problem would be issues that arise in de-lidding of parts or in parts with flip-chip designs, etc. The VDBP method is ideally suited to test modern avionics designs which increasingly incorporate commercial off-the-shelf (COTS) parts and units. Johnson Space Center (JSC) developed software provides assistance to users in developing the radiation characterization data from the raw test data.

  11. Radiation physics, biophysics, and radiation biology

    Energy Technology Data Exchange (ETDEWEB)

    Hall, E.J.; Zaider, M.

    1993-05-01

    Research at the Center for Radiological Research is a multidisciplenary blend of physics, chemistry and biology aimed at understanding the mechanisms involved in the health problems resulting from human exposure to ionizing radiations. The focus is increased on biochemistry and the application of the techniques of molecular biology to the problems of radiation biology. Research highlights of the program from the past year are described. A mathematical model describing the production of single-strand and double-strand breaks in DNA as a function radiation quality has been completed. For the first time Monte Carlo techniques have been used to obtain directly the spatial distribution of DNA moieties altered by radiation. This information was obtained by including the transport codes a realistic description of the electronic structure of DNA. We have investigated structure activity relationships for the potential oncogenicity of a new generation of bioreductive drugs that function as hypoxic cytotoxins. Experimental and theoretical investigation of the inverse dose rate effect, whereby medium LET radiations actually produce an c effect when the dose is protracted, is now at a point where the basic mechanisms are reasonably understood and the complex interplay between dose, dose rate and radiation quality which is necessary for the effect to be present can now be predicted at least in vitro. In terms of early radiobiological damage, a quantitative link has been established between basic energy deposition and locally multiply damaged sites, the radiochemical precursor of DNA double strand breaks; specifically, the spatial and energy deposition requirements necessary to form LMDs have been evaluated. For the first time, a mechanically understood biological fingerprint'' of high-LET radiation has been established. Specifically measurement of the ratio of inter-to intra-chromosomal aberrations produces a unique signature from alpha-particles or neutrons.

  12. Covariant anomalies and Hawking radiation from Kaluza–Klein AdS ...

    Indian Academy of Sciences (India)

    The KK-AdS black hole considered is a non-extremal charged rotating solution in the theory of 4D gauged supergravity. Its Hawking fluxes of electric charge, angular momentum and energy momentum tensor are derived here. Our results support the common view that Hawking radiation is the quantum effect arising at the ...

  13. Radiation processes in astrophysics

    CERN Document Server

    Tucker, Wallace H

    1975-01-01

    The purpose of this book is twofold: to provide a brief, simple introduction to the theory of radiation and its application in astrophysics and to serve as a reference manual for researchers. The first part of the book consists of a discussion of the basic formulas and concepts that underlie the classical and quantum descriptions of radiation processes. The rest of the book is concerned with applications. The spirit of the discussion is to present simple derivations that will provide some insight into the basic physics involved and then to state the exact results in a form useful for applications. The reader is referred to the original literature and to reviews for rigorous derivations.The wide range of topics covered is illustrated by the following table of contents: Basic Formulas for Classical Radiation Processes; Basic Formulas for Quantum Radiation Processes; Cyclotron and Synchrotron Radiation; Electron Scattering; Bremsstrahlung and Collision Losses; Radiative Recombination; The Photoelectric Effect; a...

  14. Radiation and Thyroid Cancer

    Science.gov (United States)

    Albi, Elisabetta; Cataldi, Samuela; Lazzarini, Andrea; Codini, Michela; Beccari, Tommaso; Ambesi-Impiombato, Francesco Saverio; Curcio, Francesco

    2017-01-01

    Radiation-induced damage is a complex network of interlinked signaling pathways, which may result in apoptosis, cell cycle arrest, DNA repair, and cancer. The development of thyroid cancer in response to radiation, from nuclear catastrophes to chemotherapy, has long been an object of study. A basic overview of the ionizing and non-ionizing radiation effects of the sensitivity of the thyroid gland on radiation and cancer development has been provided. In this review, we focus our attention on experiments in cell cultures exposed to ionizing radiation, ultraviolet light, and proton beams. Studies on the involvement of specific genes, proteins, and lipids are also reported. This review also describes how lipids are regulated in response to the radiation-induced damage and how they are involved in thyroid cancer etiology, invasion, and migration and how they can be used as both diagnostic markers and drug targets. PMID:28445397

  15. Foundations of radiation hydrodynamics

    Science.gov (United States)

    Mihalas, D.; Mihalas, B. W.

    This book is the result of an attempt, over the past few years, to gather the basic tools required to do research on radiating flows in astrophysics. The microphysics of gases is discussed, taking into account the equation of state of a perfect gas, the first and second law of thermodynamics, the thermal properties of a perfect gas, the distribution function and Boltzmann's equation, the collision integral, the Maxwellian velocity distribution, Boltzmann's H-theorem, the time of relaxation, and aspects of classical statistical mechanics. Other subjects explored are related to the dynamics of ideal fluids, the dynamics of viscous and heat-conducting fluids, relativistic fluid flow, waves, shocks, winds, radiation and radiative transfer, the equations of radiation hydrodynamics, and radiating flows. Attention is given to small-amplitude disturbances, nonlinear flows, the interaction of radiation and matter, the solution of the transfer equation, acoustic waves, acoustic-gravity waves, basic concepts of special relativity, and equations of motion and energy.

  16. Radiation exposure and pregnancy.

    Science.gov (United States)

    Labant, Amy; Silva, Christina

    2014-01-01

    Radiological exposure from nuclear power reactor accidents, transportation of nuclear waste accidents, industrial accidents, or terrorist activity may be a remote possibility, but it could happen. Nurses must be prepared to evaluate and treat pregnant women and infants who have been exposed to radiation, and to have an understanding of the health consequences of a nuclear or radiological incident. Pregnant women and infants are a special group of patients who need consideration when exposed to radiation. Initial care requires thorough assessment and decisions regarding immediate care needs. Ongoing care is based on type and extent of radiation exposure. With accurate, comprehensive information and education, nurses will be better prepared to help mitigate the effects of radiation exposure to pregnant women and infants following a radiological incident. Information about radiation, health effects of prenatal radiation exposure, assessment, patient care, and treatment of pregnant women and infants are presented.

  17. Dosimetry for radiation processing

    DEFF Research Database (Denmark)

    Miller, Arne

    1986-01-01

    During the past few years significant advances have taken place in the different areas of dosimetry for radiation processing, mainly stimulated by the increased interest in radiation for food preservation, plastic processing and sterilization of medical products. Reference services both...... and sterilization dosimetry, optichromic dosimeters in the shape of small tubes for food processing, and ESR spectroscopy of alanine for reference dosimetry. In this paper the special features of radiation processing dosimetry are discussed, several commonly used dosimeters are reviewed, and factors leading...

  18. Electromagnetic Radiation Analysis

    Science.gov (United States)

    1978-04-10

    A methodology is given for determining whether electromagnetic radiation of sufficient strength to cause performance degradation to the test item...exists at the test item location. The results of an electromagnetic radiation effects test are used to identify the radio frequencies and electromagnetic ... radiation levels to which the test item is susceptible. Further, using a test bed, comparisons are made with the representative signal levels to

  19. Galactic Radiation Belts.

    Science.gov (United States)

    1982-01-15

    was formulated by Ortwein et al. 13for analysis of the Jovian radio emission. These authors de- rived their results for an arbitrary dipole-axis...galactic radio sources with the Jovian radiation-belt source, 17suggests a=. intriguing similarity. The related questions of why galactic radiation belts...Space Sciences Laboratory: Atmospheric and ionospheric physics, radiation from the atmosphere, densfty and composition of the upper atmosphere, aurorae

  20. Radiation Physics, Biophysics and Radiation Biology

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, H. H.; Hall, E. J.

    1978-02-01

    Research under Contract EY-76-C-02-3243 has been carried out in the area of Radiation Physics, Biophysics and Radiation Biology. During the period of this contract the major accomplishments include, in Physics, the refinement of tissue equivalent dosimetry, the formulation of the concepts of microdosimetry, the development of apparatus used in microdosimetry, and the development of ionization chambers with internal gas multiplication. Principal contributions in Radiobiology have included the determination of RBE and OER as a function·of neutron energy, the study of combined effects of radiation and a variety of other agents, and the investigation of the transformation of cells in tissue culture. Theoretical research centered around the development of the theoretical framework of microdosimetry and the establishment of the Theory of Dual Radiation Action. In a cooperative effort with Brookhaven National Laboratory, a major accelerator facility dedicated exclusively to Radiobiology and Radiation Physics, has been developed. Members of the laboratory have performed extensive. service to national and international organizations.

  1. NEW RADIATION RESISTANT GREASES

    Energy Technology Data Exchange (ETDEWEB)

    DasGupta, Sharda; Slobodian, J.T.

    1962-11-20

    New radiation resistant greases were prepared from commercially available greases by carrying out radioinduced reactions with styrene. The radiation tolerances of the products were 250-1000 fold more than the starting materials and any product of similar properties now available. The various properties of the new products initially and after exposure to large radiation doses were in no case inferior to the original greases and in some respects improvements were observed. Radiation tolerance of commercial greases could be enhanced by the addition of polystyrene to form a physical mixture rather than copolymers. The reaction mechanisms involved at all stages were studied using infrared spectroscopic techniques. (P.C.H.)

  2. Radiation hormesis in plant

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Lee, Byung Hun; Shin, In Chul; Lim, Young Taek

    2000-04-01

    This research was performed to investigate the effects of low dose {gamma}-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as subsequent high doses of radiation or Phytophthora blight of pepper could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant (POD) were accomplished in the plant irradiated with different dose of {gamma}-ray. (author)

  3. In Situ Ductal Carcinoma Arising in Benign Phyllodes Tumor in 19-Year Old Patient: A Case Report

    Science.gov (United States)

    Çolakoğlu, Muhammet Kadri; Yenidoğan, Erdinç; Akgül, Gökhan Giray; Irkkan, Sultan Çiğdem; Özdemir, Yılmaz; Gülçelik, Mehmet Ali; Çamlıbel, Mithat

    2014-01-01

    Phyllodes tumors are fibroepithelial lesions and malign forms are rare neoplasms with lower than 1% of all primary breast tumors. Malign forms are usually behaves like sarcomas because they occur in the stroma of the breast. Also proliferation of epithelium occurs and even it is less often, the epithelial component of phyllodes tumors can transform into malignancy too. This epithelial malignancies are usually in the form of infiltrative carcinomas and non-invasive tumors arising in benign phyllodes tumors are much rarer but can be seen. Literature include very few cases about this situation and cases are usually old woman. We report a 19-year old patient who was diagnosed with ductal carcinoma in situ arising in benign phyllodes tumor of the breast. PMID:28331678

  4. Multimodality Imaging Approach towards Primary Aortic Sarcomas Arising after Endovascular Abdominal Aortic Aneurysm Repair: Case Series Report

    Energy Technology Data Exchange (ETDEWEB)

    Kamran, Mudassar, E-mail: kamranm@mir.wustl.edu; Fowler, Kathryn J., E-mail: fowlerk@mir.wustl.edu; Mellnick, Vincent M., E-mail: mellnickv@mir.wustl.edu [Washington University School of Medicine, Mallinckrodt Institute of Radiology (United States); Sicard, Gregorio A., E-mail: sicard@wudosis.wustl.edu [Washington University School of Medicine, Department of Surgery (United States); Narra, Vamsi R., E-mail: narrav@mir.wustl.edu [Washington University School of Medicine, Mallinckrodt Institute of Radiology (United States)

    2016-06-15

    Primary aortic neoplasms are rare. Aortic sarcoma arising after endovascular aneurysm repair (EVAR) is a scarce subset of primary aortic malignancies, reports of which are infrequent in the published literature. The diagnosis of aortic sarcoma is challenging due to its non-specific clinical presentation, and the prognosis is poor due to delayed diagnosis, rapid proliferation, and propensity for metastasis. Post-EVAR, aortic sarcomas may mimic other more common aortic processes on surveillance imaging. Radiologists are rarely knowledgeable about this rare entity for which multimodality imaging and awareness are invaluable in early diagnosis. A series of three pathologically confirmed cases are presented to display the multimodality imaging features and clinical presentations of aortic sarcoma arising after EVAR.

  5. Giant serous cystadenoma arising from an accessory ovary in a morbidly obese 11-year-old girl: a case report

    Directory of Open Access Journals (Sweden)

    Sharatz Steven M

    2008-01-01

    Full Text Available Abstract Introduction Ectopic ovarian tissue is an unusual entity, especially if it is an isolated finding thought to be of embryological origin. Case presentation An 11-year-old, morbidly obese female presented with left flank pain, nausea, and irregular menses. Various diagnostic procedures suggested a large ovarian cyst, and surgical resection was performed. Conclusion Histologically, the resected mass was not of tubal origin as suspected, but a serous cystadenoma arising from ovarian tissue. The patient's two normal, eutopic ovaries were completely uninvolved and unaffected. A tumor arising from ectopic ovarian tissue of embryological origin seems the most likely explanation. We suggest refining the descriptive nomenclature so as to more precisely characterize the various presentations of ovarian ectopia.

  6. Analytical Treatment and Convergence of the Adomian Decomposition Method for Instability Phenomena Arising during Oil Recovery Process

    Directory of Open Access Journals (Sweden)

    Ramakanta Meher

    2013-01-01

    Full Text Available An abstract result is proved for the convergence of Adomian decomposition method for partial differential equations that model porous medium equation. Moreover, we prove that this decomposition scheme applied to a porous medium equation arising in instability phenomena in double phase flow through porous media is convergent in a suitable Hilbert space. Furthermore, this technique is utilized to find closed-form solutions for the problem under consideration.

  7. Three years follow-up after cryoablation of a right atrial myxoma arising from the Koch's triangle.

    Science.gov (United States)

    Wauthy, P; Mircev, D; Marinakis, S

    2016-11-22

    We reported 3 years ago the use of cryoablation in the treatment of a right atrium myxoma arising from the Koch's triangle. The atrioventricular conduction was successfully preserved. Today, after 3 years follow-up, the patient remains with a conducted sinus rhythm and is free of recurrence. Even if extensive resection of the stack of the myxoma remains the first choice attitude, cryoablation could be considered as a serious second choice alternative.

  8. An ADER-type scheme for a class of equations arising from the water-wave theory

    OpenAIRE

    Montecinos G.I.; López-Rios J.C.; Lecaros R.; Ortega J.H.; Toro E.F.

    2016-01-01

    In this work we propose a numerical strategy to solve a family of partial differential equations arising from the water-wave theory. These problems may contain four terms; a source which is an algebraic function of the solution, a convective part involving first order spatial derivatives of the solution, a diffusive part involving second order spatial derivatives and the transient part. Unlike partial differential equations of hyperbolic or parabolic type, where the transient part is the time...

  9. Exact and semiclassical approach to a class of singular integral operators arising in fluid mechanics and quantum field theory

    Energy Technology Data Exchange (ETDEWEB)

    Fateev, V A [Laboratoire de Physique Mathematique, Universite Montpellier II, Pl. E. Bataillon, 34095 Montpellier (France); De Pietri, R [Dipartimento di Fisica, Universita di Parma, and INFN, Gruppo Collegato di Parma, 43100 Parma (Italy); Onofri, E [Dipartimento di Fisica, Universita di Parma, and INFN, Gruppo Collegato di Parma, 43100 Parma (Italy)

    2004-11-26

    A class of singular integral operators, encompassing two physically relevant cases arising in perturbative QCD and in classical fluid dynamics, is presented and analysed. It is shown that three special values of the parameters allow for an exact eigenfunction expansion; these can be associated with Riemannian symmetric spaces of rank 1 with positive, negative or vanishing curvature. For all other cases an accurate semiclassical approximation is derived, based on the identification of the operators with a peculiar Schroedinger-like operator.

  10. On a Five-Dimensional Chaotic System Arising from Double-Diffusive Convection in a Fluid Layer

    Directory of Open Access Journals (Sweden)

    R. Idris

    2013-01-01

    Full Text Available A chaotic system arising from double-diffusive convection in a fluid layer is investigated in this paper based on the theory of dynamical systems. A five-dimensional model of chaotic system is obtained using the Galerkin truncated approximation. The results showed that the transition from steady convection to chaos via a Hopf bifurcation produced a limit cycle which may be associated with a homoclinic explosion at a slightly subcritical value of the Rayleigh number.

  11. Primary carcinoid tumor arising within mature teratoma of the kidney: report of a rare entity and review of the literature

    Directory of Open Access Journals (Sweden)

    Parwani Anil V

    2007-05-01

    Full Text Available Abstract Background Primary carcinoid tumor arising within mature teratoma of the kidney is extremely rare, and their clinicopathologic features are not well described. Our objective was to further define the clinical features and pathologic spectra of primary carcinoid tumor arising within mature teratoma of the kidney. Methods Six previously reported case reports were identified using MEDLINE and a subsequent bibliographic search of all pertinent reports and reviews was performed. We also searched the electronic medical archival records of our institution and identified one additional unreported case. Data were extracted on the demographics, predisposing factors, clinical presentation, radiographic features, gross pathology, microscopic pathology, immunophenotype, therapy, and outcome of each of these seven cases. Results Primary carcinoid tumor arising within mature teratoma of the kidney was found at a mean age of 41.4 years. Of the 7 cases, 3 were female and 4 were male. Two of the 7 cases (28.6% were associated with horseshoe kidney. It typically presented with abdominal pain without carcinoid syndrome. It typical radiologic appearance was well circumscribed partly calcified Bosniak II-III lesion. Histologically, the carcinoid tumor showed monotonous small round cells arranged in classic anastomosing cords/ribbons intermixed with solid nests. Surgery was curative, no additional treatment was required, no local recurrences occurred, and no metastases occurred in all 7 cases. The 3 cases with available outcome data were alive at the time of publication of their respective cases (mean, 5 months. Conclusion Primary carcinoid tumor arising within mature teratoma of the kidney is a rare tumor that typically presents with abdominal pain without carcinoid syndrome. It is not associated with local recurrence and metastasis, is surgically curable, and has excellent prognosis.

  12. Numerical study of nonlinear singular fractional differential equations arising in biology by operational matrix of shifted Legendre polynomials

    Directory of Open Access Journals (Sweden)

    D. Jabari Sabeg

    2016-10-01

    Full Text Available In this paper, we present a new computational method for solving nonlinear singular boundary value problems of fractional order arising in biology. To this end, we apply the operational matrices of derivatives of shifted Legendre polynomials to reduce such problems to a system of nonlinear algebraic equations. To demonstrate the validity and applicability of the presented method, we present some numerical examples.

  13. Radiation physics, biophysics, and radiation biology

    Energy Technology Data Exchange (ETDEWEB)

    Hall, E.J.

    1992-05-01

    The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent.

  14. Capturing opportunities and meeting challenges in radiation protection.

    Science.gov (United States)

    Kase, Kenneth R

    2015-02-01

    This summary of the 2014 Annual Meeting of the National Council on Radiation Protection and Measurement (NCRP) captures the opportunities presented during the Warren K. Sinclair Keynote Address, the Lauriston S. Taylor Lecture, and the six scientific sessions including the subsequent questions and answers. It captures the important issues that emerge in these opportunities and discusses the challenges that they bring to radiation protection. These opportunities arise in the basic sciences; in operational areas such as emerging technologies, preparing for the improbable but possible event, industry and medicine; and in education, communication and policy. The challenges include identifying the most important aspects of radiation protection and measurement, prioritizing them in accordance with the NCRP mission, and gaining support for the activities of the NCRP to address these issues in the fulfillment of its charter.

  15. Quantum description of radiative decay in optical cavities

    Science.gov (United States)

    Oppermann, J.; Straubel, J.; Słowik, K.; Rockstuhl, C.

    2018-01-01

    We derive the quantum mechanical description of light-matter interactions in optical cavities characterized solely by radiative decay. Unique to radiative decay is the conservation of photon number and coherence, in stark contrast to absorptive losses. This prohibits the description of such cavities by traditional means, e.g., coupling it to a bath of harmonic oscillators into which energy is dissipated. Here, we propose a description of cavities with radiative decay by introducing cavity and noise operators in terms of scattering modes. A multimode input-output formalism to predict measurable far field quantities arises naturally. We apply our general model to the special case of the single excitation regime. We find dynamics reminiscent of the dissipative Jaynes-Cummings model, but with vanishing backaction and a rich temporal and spectral structure of the output modes.

  16. Radiative transfer in a polluted urban planetary boundary layer

    Science.gov (United States)

    Viskanta, R.; Johnson, R. O.; Bergstrom, R. W.

    1977-01-01

    Radiative transfer in a polluted urban atmosphere is studied using a dynamic model. The diurnal nature of radiative transfer for summer conditions is simulated for an urban area 40 km in extent and the effects of various parameters arising in the problem are investigated. The results of numerical computations show that air pollution has the potential of playing a major role in the radiative regime of the urban area. Absorption of solar energy by aerosols in realistic models of urban atmosphere are of the same order of magnitude as that due to water vapor. The predicted effect of the air pollution aerosol in the city is to warm the earth-atmosphere system, and the net effect of gaseous pollutant is to warm the surface and cool the planetary boundary layer, particularly near the top.

  17. Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Pollom, Erqi L.; Deng, Lei [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Pai, Reetesh K. [Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (United States); Brown, J. Martin; Giaccia, Amato; Loo, Billy W.; Shultz, David B.; Le, Quynh Thu; Koong, Albert C. [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States); Chang, Daniel T., E-mail: dtchang@stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (United States)

    2015-07-01

    Combining the latest targeted biologic agents with the most advanced radiation technologies has been an exciting development in the treatment of cancer patients. Stereotactic body radiation therapy (SBRT) is an ablative radiation approach that has become established for the treatment of a variety of malignancies, and it has been increasingly used in combination with biologic agents, including those targeting angiogenesis-specific pathways. Multiple reports have emerged describing unanticipated toxicities arising from the combination of SBRT and angiogenesis-targeting agents, particularly of late luminal gastrointestinal toxicities. In this review, we summarize the literature describing these toxicities, explore the biological mechanism of action of toxicity with the combined use of antiangiogenic therapies, and discuss areas of future research, so that this combination of treatment modalities can continue to be used in broader clinical contexts.

  18. Assessment by human research ethics committees of potential conflicts of interest arising from pharmaceutical sponsorship of clinical research.

    Science.gov (United States)

    Newcombe, J P; Kerridge, I H

    2007-01-01

    Conflicts of interest arising from pharmaceutical industry sponsorship of clinical research have the potential to bias research outcomes and ultimately prejudice patient care. It is unknown how Australian Human Research Ethics Committees (HREC) assess and manage such conflicts of interest. We aimed to gain an understanding of how HREC approach the problem of potential conflicts of interest arising from pharmaceutical sponsorship of clinical research. We conducted a survey of HREC chairpersons in New South Wales. HREC vary widely in their approaches to conflicts of interest, including in their use of National Health and Medical Research Council guidelines, which were often misinterpreted or overlooked. Many committees rely primarily on researchers disclosing potential conflicts of interest, whereas a majority of HREC use disclosure to research participants as the primary tool for preventing and managing conflicts of interest. Almost no HREC place limitations on researcher relationships with pharmaceutical companies. These findings suggest reluctance on the part of HREC to regulate many potential conflicts of interest between researchers and pharmaceutical sponsors, which may arise from uncertainty regarding the meaning or significance of conflicts of interest in research, from ambiguity surrounding the role of HREC in assessing and managing conflicts of interest in research or from misinterpretation or ignorance of current National Health and Medical Research Council guidelines. Further review of policies and practices in this important area may prove beneficial in safeguarding clinical research and patient care while promoting continuing constructive engagement with the pharmaceutical industry.

  19. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    Energy Technology Data Exchange (ETDEWEB)

    Hendry, Jolyon H; Sohrabi, Mehdi; Burkart, Werner [Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna (Austria); Simon, Steven L [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States); Wojcik, Andrzej [Institute of Nuclear Chemistry and Technology, Warsaw (Poland); Cardis, Elisabeth [Centre for Research in Environmental Epidemiology (CREAL), Municipal Institute of Medical Research (IMIM-Hospital del Mar) and CIBER Epidemiologia y Salud Publica - CIBERESP, Barcelona (Spain); Laurier, Dominique; Tirmarche, Margot [Radiobiology and Epidemiology Department, Radiological and Human Health Division, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses (France); Hayata, Isamu [National Institute of Radiological Sciences, Chiba (Japan)], E-mail: jhendry2002uk@yahoo.com

    2009-06-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of {sup 222}Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case-control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case-control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors.

  20. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    Science.gov (United States)

    Hendry, Jolyon H; Simon, Steven L; Wojcik, Andrzej; Sohrabi, Mehdi; Burkart, Werner; Cardis, Elisabeth; Laurier, Dominique; Tirmarche, Margot; Hayata, Isamu

    2009-06-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of (222)Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case-control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case-control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors.

  1. Human exposure to high natural background radiation: what can it teach us about radiation risks?

    Science.gov (United States)

    Hendry, Jolyon H; Simon, Steven L; Wojcik, Andrzej; Sohrabi, Mehdi; Burkart, Werner; Cardis, Elisabeth; Laurier, Dominique; Tirmarche, Margot; Hayata, Isamu

    2014-01-01

    Natural radiation is the major source of human exposure to ionising radiation, and its largest contributing component to effective dose arises from inhalation of 222Rn and its radioactive progeny. However, despite extensive knowledge of radiation risks gained through epidemiologic investigations and mechanistic considerations, the health effects of chronic low-level radiation exposure are still poorly understood. The present paper reviews the possible contribution of studies of populations living in high natural background radiation (HNBR) areas (Guarapari, Brazil; Kerala, India; Ramsar, Iran; Yangjiang, China), including radon-prone areas, to low dose risk estimation. Much of the direct information about risk related to HNBR comes from case–control studies of radon and lung cancer, which provide convincing evidence of an association between long-term protracted radiation exposures in the general population and disease incidence. The success of these studies is mainly due to the careful organ dose reconstruction (with relatively high doses to the lung), and to the fact that large-scale collaborative studies have been conducted to maximise the statistical power and to ensure the systematic collection of information on potential confounding factors. In contrast, studies in other (non-radon) HNBR areas have provided little information, relying mainly on ecological designs and very rough effective dose categorisations. Recent steps taken in China and India to establish cohorts for follow-up and to conduct nested case–control studies may provide useful information about risks in the future, provided that careful organ dose reconstruction is possible and information is collected on potential confounding factors. PMID:19454802

  2. Electromagnetic radiation detector

    Science.gov (United States)

    Benson, Jay L.; Hansen, Gordon J.

    1976-01-01

    An electromagnetic radiation detector including a collimating window, a cathode member having a photoelectric emissive material surface angularly disposed to said window whereby radiation is impinged thereon at acute angles, an anode, separated from the cathode member by an evacuated space, for collecting photoelectrons emitted from the emissive cathode surface, and a negatively biased, high transmissive grid disposed between the cathode member and anode.

  3. DRUGS FOR RADIATION PROTECTION,

    Science.gov (United States)

    Radiation Protection , pub. 1961), are not repeated. Bibliographical data are compiled at the end of the book; references are listed alphabetically and...reference book of 1961 are not given. Because of the great influence of the oxygen effect on the action of drugs for radiation protection , the

  4. RADIATION AND SURGERY

    African Journals Online (AJOL)

    Dr. S.A. Adewuyi

    Radiotherapy and Oncology Center, A. B. U. Teaching Hospital, Shika – Zaria ... history of premenopausal bilateral breast cancer in ... of the cancer patients; rather it invites a new effort to provide patients with the best quality of life that surgery can offer3, 4, 5 . Radiation Therapy. The aim of radiation therapy is to deliver a ...

  5. New sources of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Schimmerling, W.

    1979-09-01

    An attempt is made to select examples of radiation sources whose application may make new or unconventional demands on radiation protection and dosimetry. A substantial body of knowledge about high energy facilities exists and, partly for this reason, the great high energy accelerators are mentioned only briefly.

  6. Semiconductor radiation detection systems

    CERN Document Server

    2010-01-01

    Covers research in semiconductor detector and integrated circuit design in the context of medical imaging using ionizing radiation. This book explores other applications of semiconductor radiation detection systems in security applications such as luggage scanning, dirty bomb detection and border control.

  7. Atoms, Molecules and Radiation

    Indian Academy of Sciences (India)

    IAS Admin

    2015-11-10

    Nov 10, 2015 ... Module 3: Interaction of electromagnetic radiation with matter: Quantum theory of radiation, spontaneous, stimulated emission and absorption probabilities, electric dipole selection rules, Einstein A and B coefficients, Rabi coefficients, Thomson Scattering, Jaynes-Cummings Model. Module 4: Molecules ...

  8. Radiation`96. Conference handbook

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The conference program includes eight invited lectures which cover a range of contemporary topics in radiation science and technology. In addition, thirty-two oral papers were presented, along with forty-five posters. The conference handbook contains one-page precis or extended abstracts of all presentations, and is a substantial compendium of current radiation research in Australia.

  9. Radiation effects in space

    Energy Technology Data Exchange (ETDEWEB)

    Fry, R.J.M.

    1987-07-01

    As more people spend more time in space, and the return to the moon and exploratory missions are considered, the risks require continuing examination. The effects of microgravity and radiation are two potential risks in space. These risks increase with increasing mission duration. This document considers the risk of radiation effects in space workers and explorers. 17 refs., 1 fig., 4 tabs.

  10. Electronics for radiation detection

    CERN Document Server

    2011-01-01

    Addresses the developments in the design of semiconductor detectors and integrated circuits, in the context of medical imaging using ionizing radiation. This book explains how circuits for radiation are built, focusing on practical information about how they are being used, rather than mathematical details.

  11. Radiation Therapy - Multiple Languages

    Science.gov (United States)

    ... W XYZ List of All Topics All Radiation Therapy - Multiple Languages To use the sharing features on this page, ... Information Translations Vietnamese (Tiếng Việt) Expand Section Radiation Therapy - Tiếng Việt (Vietnamese) ... Health Information Translations Characters not displaying correctly on this page? See language display issues . Return to the MedlinePlus Health Information ...

  12. ALICE HMPID Radiator Vessel

    CERN Multimedia

    2003-01-01

    View of the radiator vessels of the ALICE/HMPID mounted on the support frame. Each HMPID module is equipped with 3 indipendent radiator vessels made out of neoceram and fused silica (quartz) windows glued together. The spacers inside the vessel are needed to stand the hydrostatic pressure. http://alice-hmpid.web.cern.ch/alice-hmpid

  13. CHERENKOV RADIATION DETECTOR

    African Journals Online (AJOL)

    ES Obe

    1981-03-01

    Mar 1, 1981 ... Most of Radiation detectors based on the Cherenkov Effect are essentially very bulky and expensive for schools and colleges. An inexpensive yet very compact radiation detector is designed, built and tested. It is used to measure the Cherenkov angles for natural radioactivity from sources as. Cs137.

  14. Accelerator and radiation physics

    CERN Document Server

    Basu, Samita; Nandy, Maitreyee

    2013-01-01

    "Accelerator and radiation physics" encompasses radiation shielding design and strategies for hadron therapy accelerators, neutron facilities and laser based accelerators. A fascinating article describes detailed transport theory and its application to radiation transport. Detailed information on planning and design of a very high energy proton accelerator can be obtained from the article on radiological safety of J-PARC. Besides safety for proton accelerators, the book provides information on radiological safety issues for electron synchrotron and prevention and preparedness for radiological emergencies. Different methods for neutron dosimetry including LET based monitoring, time of flight spectrometry, track detectors are documented alongwith newly measured experimental data on radiation interaction with dyes, polymers, bones and other materials. Design of deuteron accelerator, shielding in beam line hutches in synchrotron and 14 MeV neutron generator, various radiation detection methods, their characteriza...

  15. Compound Semiconductor Radiation Detectors

    CERN Document Server

    Owens, Alan

    2012-01-01

    Although elemental semiconductors such as silicon and germanium are standard for energy dispersive spectroscopy in the laboratory, their use for an increasing range of applications is becoming marginalized by their physical limitations, namely the need for ancillary cooling, their modest stopping powers, and radiation intolerance. Compound semiconductors, on the other hand, encompass such a wide range of physical and electronic properties that they have become viable competitors in a number of applications. Compound Semiconductor Radiation Detectors is a consolidated source of information on all aspects of the use of compound semiconductors for radiation detection and measurement. Serious Competitors to Germanium and Silicon Radiation Detectors Wide-gap compound semiconductors offer the ability to operate in a range of hostile thermal and radiation environments while still maintaining sub-keV spectral resolution at X-ray wavelengths. Narrow-gap materials offer the potential of exceeding the spectral resolutio...

  16. Fading Hawking Radiation

    CERN Document Server

    Sakalli, I; Pasaoglu, H

    2012-01-01

    In this study, we explore a particular type Hawking radiation which ends with zero temperature and entropy. The appropriate black holes for this purpose are the linear dilaton black holes. In addition to the black hole choice, a recent formalism in which the Parikh-Wilczek's tunneling formalism amalgamated with quantum corrections to all orders in \\hbar is considered. The adjustment of the coefficients of the quantum corrections plays a crucial role on this particular Hawking radiation. The obtained tunneling rate indicates that the radiation is not pure thermal anymore, and hence correlations of outgoing quanta are capable of carrying away information encoded within them. Finally, we show in detail that when the linear dilaton black hole completely evaporates through such a particular radiation, entropy of the radiation becomes identical with the entropy of the black hole, which corresponds to "no information loss".

  17. Applications of ionizing radiations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-07-01

    Developments in standard applications and brand new nuclear technologies, with high impact on the future of the agriculture, medicine, industry and the environmental preservation. The Radiation Technology Center (CTR) mission is to apply the radiation and radioisotope technologies in Industry, Health, Agriculture, and Environmental Protection, expanding the scientific knowledge, improving human power resources, transferring technology, generating products and offering services for the Brazilian society. The CTR main R and D activities are in consonance with the IPEN Director Plan (2011-2013) and the Applications of Ionizing Radiation Program, with four subprograms: Irradiation of Food and Agricultural Products; Radiation and Radioisotopes Applications in Industry and Environment; Radioactive Sources and Radiation Applications in Human Health; and Radioactive Facilities and Equipment for the Applications of Nuclear Techniques.

  18. Chitosan and radiation chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Chmielewski, Andrzej G., E-mail: a.chmielewski@ichtj.waw.p [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    2010-03-15

    Chitosan as a raw material with special properties has drawn attention of scientists working in the field of radiation processing and natural polymer products development, and also of specialists working in the field of radiation protection and oncologists. Especially the applications concern reduced molecular weight chitosan which still retain its chemical structure; such form of the compound is fostering biological, physical and chemical reactivity of the product. Chitosan degrades into fragments under gamma-ray or electron beam irradiation. Antibacterial properties of the product are applied in manufacturing hydrogel for wound dressing and additional healing properties can be achieved by incorporating in the hydrogel matrix chitosan bonded silver clusters. Another possible application of chitosan is in reducing radiation damage to the radiation workers or radiation cured patients. In the case of radioisotopes oral or respiratory chitosan-based materials can be applied as chelators. Applications of chitosan in oncology are also reported.

  19. Synchrotron radiation sources

    Energy Technology Data Exchange (ETDEWEB)

    van Steenbergen, A.

    1979-01-01

    As a result of the exponential growth of the utilization of synchrotron radiation for research in the domain of the material sciences, atomic and molecular physics, biology and technology, a major construction activity has been generated towards new dedicated electron storage rings, designed optimally for synchrotron radiation applications, also, expansion programs are underway at the existing facilities, such as DORIS, SPEAR, and VEPP. In this report the basic properties of synchrotron radiation will be discussed, a short overview will be given of the existing and new facilities, some aspects of the optimization of a structure for a synchrotron radiation source will be discussed and the addition of wigglers and undulators for spectrum enhancement will be described. Finally, some parameters of an optimized synchrotron radiation source will be given.

  20. Electrodynamics of Radiating Charges

    Directory of Open Access Journals (Sweden)

    Øyvind Grøn

    2012-01-01

    Full Text Available The theory of electrodynamics of radiating charges is reviewed with special emphasis on the role of the Schott energy for the conservation of energy for a charge and its electromagnetic field. It is made clear that the existence of radiation from a charge is not invariant against a transformation between two reference frames that has an accelerated motion relative to each other. The questions whether the existence of radiation from a uniformly accelerated charge with vanishing radiation reaction force is in conflict with the principle of equivalence and whether a freely falling charge radiates are reviewed. It is shown that the resolution of an electromagnetic “perpetuum mobile paradox” associated with a charge moving geodetically along a circular path in the Schwarzschild spacetime requires the so-called tail terms in the equation of motion of a charged particle.

  1. Radiative impacts of ozone and other radiatively active components

    Energy Technology Data Exchange (ETDEWEB)

    Stordal, F.; Larsen, T.A.; Myhre, G.; Zetterberg, L.

    1996-07-01

    Radiative transfer calculations have been performed with two models of infrared radiation (broad band and line-by-line) and one model for ultraviolet and visible radiation (discrete ordinate method). The calculations are aimed at quantifying the radiative effects of radiatively active gases, in particular ozone. Seasonal variations and trends in the radiative forcing due to presence of ozone in the atmosphere is studied, based on observed ozone profiles from ozone soundings at selected Nordic locations. 15 refs., 28 figs., 8 tabs.

  2. Health Risk Assessment of Natural Background Radiation in Residents of Khorramabad, Iran

    Directory of Open Access Journals (Sweden)

    Mojtaba Ghorbanipour

    2017-03-01

    Full Text Available Introduction Radioactive materials naturally exist in the world. Indeed, approximately 82% of human-absorbed radiation doses, which are out of human control, arise from natural sources of radiation including cosmic, terrestrial, and exposure through inhalation or ingestion. Thus, the aim of the present study was to estimate health risk, as well as the effective and organ doses from naturally occurring background radiation in residents living in the vicinity of Khorramabad, Iran. Materials and Methods This cross-sectional study was carried out in Khorramabad, Iran. The measurements were performed using Geiger-Muller detector (RDS-110 during daylight from April to June, 2015. The natural gamma radiation measurements were made both indoor and outdoor across five regions of Khorramabad (north, south, west, east, and center. Results The estimated mean absorbed dose rate in outdoor and indoor zones were 0.09±0.024 and 0.117±0.032 mSvy-1, respectively. Additionally, the mean annual effective dose was calculated as 0.69±0.19 mSvy-1, while the estimated health risk probability was 0.0345%. Conclusion The average annual effective dose arising from gamma background radiation was higher than global values. Therefore, more studies are required to examine the relationship between radiation-induced effects and the natural background radiation level in Khorramabad.

  3. Numerical Simulations of Turbulent Molecular Clouds Regulated by Radiation Feedback Forces. II. Radiation-Gas Interactions and Outflows

    Science.gov (United States)

    Raskutti, Sudhir; Ostriker, Eve C.; Skinner, M. Aaron

    2017-12-01

    Momentum deposition by radiation pressure from young, massive stars may help to destroy molecular clouds and unbind stellar clusters by driving large-scale outflows. We extend our previous numerical radiation hydrodynamic study of turbulent star-forming clouds to analyze the detailed interaction between non-ionizing UV radiation and the cloud material. Our simulations trace the evolution of gas and star particles through self-gravitating collapse, star formation, and cloud destruction via radiation-driven outflows. These models are idealized in that we include only radiation feedback and adopt an isothermal equation of state. Turbulence creates a structure of dense filaments and large holes through which radiation escapes, such that only ˜50% of the radiation is (cumulatively) absorbed by the end of star formation. The surface density distribution of gas by mass as seen by the central cluster is roughly lognormal with {σ }{ln{{Σ }}}=1.3{--}1.7, similar to the externally projected surface density distribution. This allows low surface density regions to be driven outwards to nearly 10 times their initial escape speed {v}{esc}. Although the velocity distribution of outflows is broadened by the lognormal surface density distribution, the overall efficiency of momentum injection to the gas cloud is reduced because much of the radiation escapes. The mean outflow velocity is approximately twice the escape speed from the initial cloud radius. Our results are also informative for understanding galactic-scale wind driving by radiation, in particular, the relationship between velocity and surface density for individual outflow structures and the resulting velocity and mass distributions arising from turbulent sources.

  4. 2015 Space Radiation Standing Review Panel

    Science.gov (United States)

    Steinberg, Susan

    2015-01-01

    big data” study must be used with caution. The general scientific issues of reproducibility, details of experimental methods and data analysis from preclinical and basic research laboratories have been raised broadly over the last few years (not specific to this work) and indicate that caution must be applied in the ways these data are used. This pertains to preclinical data and also to phase 3 clinical trials in radiation oncology and medical oncology. Of course, appropriate use and analysis of these “big-data” sets also offer the potential of pinpointing limitations and extracting remaining useful information. Emphasis should be placed on the latter possibility. A key target is risk reduction from radiation exposure. Progress of the entire space program, now moving towards the Mars mission, requires timely answers to key components of human risk, which are known to be complex. Periodic review of progress should be conducted with additional resources directed into achieving critical milestones. Turning the long red bars to yellow and green (or for some risks such as CNS possibly to grey) must be high priority. That such progress will require new science and not engineering means that it should be viewed in a knowledge-based light. The technology-based aspects of engineering issues are certainly as important, however, science and knowledge-based problems are solved in a different way than engineering. Timelines for engineering are more predictable, while for science, progress can be methodical with occasional major incremental findings that can rapidly change the rate of progress. As opportunities for rapid incremental changes arise, periodic enhancement of investment is strongly recommended to enable such new knowledge to be quickly and efficiently exploited. Collaborations and linkages with National Institute of Allergy and Infectious Diseases (NIAID), the Biomedical Advanced Research and Development Authority (BARDA) and the Department of Defense (DoD) are in place

  5. Semiconductor radiation detectors. Device physics

    Energy Technology Data Exchange (ETDEWEB)

    Lutz, G. [Max-Planck-Institut fuer Physik, Muenchen (Germany)]|[Max-Planck-Institut fuer Extraterrestrische Physik, Garching (Germany). Semiconductor Lab.

    1999-07-01

    The following topics were dealt with: semiconductor radiation detectors, basic semiconductor structures, semiconductors, energy measurement, radiation-level measurement, position measurement, electronics of the readout function, detectors with intrinsic amplification, detector technology, device stability, radiation hardness and device simulation.

  6. Get the Facts about Radiation

    Science.gov (United States)

    ... this issue Looking Inside Get the Facts About Radiation Send us your comments Radiation can be dangerous, but it can also save lives. How can that be? Harnessed properly, radiation can help diagnose and even treat disease. So ...

  7. Biological Effects of Ionizing Radiation

    Science.gov (United States)

    Ingram, M.; Mason, W. B.; Whipple, G. H.; Howland, J. W.

    1952-04-07

    This report presents a review of present knowledge and concepts of the biological effects of ionizing radiations. Among the topics discussed are the physical and chemical effects of ionizing radiation on biological systems, morphological and physiological changes observed in biological systems subjected to ionizing radiations, physiological changes in the intact animal, latent changes following exposure of biological systems to ionizing radiations, factors influencing the biological response to ionizing radiation, relative effects of various ionizing radiations, and biological dosimetry.

  8. Nonlinearity of radiation health effects.

    OpenAIRE

    Pollycove, M

    1998-01-01

    The prime concern of radiation protection policy since 1959 has been to protect DNA from damage. In 1994 the United Nations Scientific Community on the Effects of Atomic Radiation focused on biosystem response to radiation with its report Adaptive Responses to Radiation of Cells and Organisms. The 1995 National Council on Radiation Protection and Measurements report Principles and Application of Collective Dose in Radiation Protection states that because no human data provides direct support ...

  9. Beneficial uses of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Fox, M.R.

    1991-10-01

    An overall decline in technical literacy within the American public has come at a time when technological advances are accelerating in the United States and around the world. This had led to a large communication gulf between the general public and the technologists. Nowhere is this more evident then with the topic of radiation. Regrettably, too few people know about sources of radiation, the pervasiveness, amounts, and variabilities, and do not have a true understanding of the environment in which we live. Nor do many people know that radiation has been used in beneficial ways for decades around the world. While the general public does not know of the scientific applications to which radiation has been deployed, it nevertheless had benefited tremendously from these efforts. Thanks to the well know properties of radiation, scientific ingenuity has found many uses of radiation in chemical and agricultural research, biomedical research, in the diagnoses and treatment of hundreds of types of diseases, in industrial applications, food irradiation, and many others. This paper provides a sample of the types of uses to which radiation has been used to help advance the betterment of humankind.

  10. Radiation vulcanization of rubbers

    Energy Technology Data Exchange (ETDEWEB)

    Makuuchi, Keizo [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment

    2002-02-01

    An abstract of the radiation process of polymer materials and the polymer reaction by radiation is explained. Main radiation is 250 keV to 10 MeV of electron rays in the industry. Radiation cross-linked rubber has less the tensile strength than that by sulfur and organic peroxide crosslinking. The main origins of low tensile strength are caused by cut of backbone chain and ozone depend on radiation. Acceleration of crosslinking and short time of radiation are necessary to improve these defects. To accelerate crosslinking, we used crosslinking accelerators, for example, three poly-functional monomers (PFM). The maximum tensile strength of styrene-butadiene rubber (SBR) not added crosslinking accelerators showed 3 MPa at 110 kGy, but SBR added A-TMMT (tetramethylolmethane tetraacrylate) showed 5.5 MPa at 110 kGy. Radiation crosslinking of many kinds of rubber: isoprene (IR), SBR, CR, nitrile rubber (NBR), hydrogenated nitrile rubber (HNBR), butyl rubber (IIR), chlorinated butyl rubber (CIIR), EPM and TPE are explained. (S.Y.)

  11. Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor

    Science.gov (United States)

    Paradis, Valerie; Pote, Nicolas; Jakate, Shriram; Ferrell, Linda D

    2016-01-01

    Well-differentiated hepatocellular carcinoma in non-cirrhotic liver can show morphological features similar to hepatocellular adenoma. In rare instances, hepatocellular carcinoma can arise in the setting of hepatocellular adenoma. This study compares the immunohistochemical and cytogenetic features of the hepatocellular adenoma-like and hepatocellular carcinoma portions of these tumors. Immunohistochemistry for β-catenin, glutamine synthetase, serum amyloid A protein, glypican-3, and heat-shock protein 70 was done in 11 cases of hepatocellular carcinoma arising in hepatocellular adenoma in non-cirrhotic liver. Tumors with nuclear β-catenin and/or diffuse glutamine synthetase were considered β-catenin activated. Fluorescence in situ hybridization (FISH) was done in nine cases for gains of chromosomes 1, 8 and MYC. There were seven men (33–75 years) and four women (29–65 years). Focal atypical morphological features were seen in hepatocellular adenoma-like areas in 7 (64%) cases. Hepatocellular adenoma-like areas showed features of inflammatory hepatocellular adenoma in 7 (64%) cases; 4 of these were also serum amyloid A-positive in the hepatocellular carcinoma portion. β-catenin activation, heat-shock protein 70 positivity, and chromosomal gains on FISH were seen in the hepatocellular adenoma portion in 55%, 40%, and 56% of cases, and 73%, 60%, and 78% of cases in the hepatocellular carcinoma portion, respectively. In conclusion, the hepatocellular adenoma-like portion of most cases of hepatocellular carcinoma arising in hepatocellular adenoma shows features typically seen in hepatocellular carcinoma such as focal morphological abnormalities, β-catenin activation, heat-shock protein 70 expression, and chromosomal gains. Hepatocellular adenoma-like areas in these tumors, especially in men and older women, may represent an extremely well-differentiated variant of hepatocellular carcinoma, whereas the morphologically recognizable hepatocellular carcinoma

  12. Vortex dynamics and flow-induced vibrations arising from a vortex ring passing tangentially over a flexible plate

    Science.gov (United States)

    Pirnia, Alireza; Hu, JiaCheng; Peterson, Sean D.; Erath, Byron D.

    2017-10-01

    The extraction of energy from vortical structures advecting through an ambient environment is a topic of interest due to the potential to power miniature in situ sensors and monitors. This work investigates the vortex dynamics and flow-induced vibrations of a flexible plate arising from a vortex ring passing tangentially over it. Experimental measurements of the flow field and plate dynamics are performed in tandem with a coupled potential flow/Kirchhoff-Love plate model in order to (i) elucidate the physics of the vortex-plate interactions in the specified orientation and relate the energy exchange between the ring and the plate to the attendant vortex dynamics; (ii) validate the potential flow model and provide any needed corrections to account for the simplifying assumptions; and (iii) provide empirical data for estimating energy harvesting capabilities in the specified orientation. The plate loading arises as a result of an initial down-wash, followed quickly by a region of reduced pressure as the vortex core passes over the plate. The fundamental physics of the interaction is discussed, identifying three regimes. When the centerline of the vortex ring is positioned greater than approximately 2 vortex ring radii away from the plate it can be considered to be in the far-field, and the resulting vibrations are well predicted through potential flow, once the plate dynamics are corrected for edge effects arising from a finite plate width. As the offset distance of the vortex ring is decreased, diffusion of induced vorticity on the plate into the flow field significantly alters the fluid dynamics, pressure loading, and the resultant plate dynamics, and dramatically increases the strain energy in comparison with the potential flow model predictions. A first-order correction to the potential flow model is proposed to account for the finite plate width, while empirical correlations are presented for the plate strain energy in cases where ring/induced vorticity

  13. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells.

    Science.gov (United States)

    Pu, Jeffrey J; Hu, Rong; Mukhina, Galina L; Carraway, Hetty E; McDevitt, Michael A; Brodsky, Robert A

    2012-08-01

    Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation. Many patients with aplastic anemia and myelodysplastic syndromes also harbor small populations of glycosylphosphatidylinositol-anchor deficient cells. Patients with aplastic anemia often evolve into paroxysmal nocturnal hemoglobinuria; however, myelodysplastic syndromes seldom evolve into paroxysmal nocturnal hemoglobinuria. Here, we investigate the origin and clonality of small glycosylphosphatidylinositol-anchor deficient cell populations in aplastic anemia and myelodysplastic syndromes. We used peripheral blood flow cytometry to identify glycosylphosphatidylinositol-anchor deficient blood cells, a proaerolysin-resistant colony forming cell assay to select glycosylphosphatidylinositol-anchor deficient progenitor cells, a novel T-lymphocyte enrichment culture assay with proaerolysin selection to expand glycosylphosphatidylinositol-anchor deficient T lymphocytes, and PIG-A gene sequencing assays to identify and analyze PIG-A mutations in patients with aplastic anemia and myelodysplastic syndromes. Twelve of 15 aplastic anemia patients were found to harbor a small population of glycosylphosphatidylinositol-anchor deficient granulocytes; 11 of them were found to harbor a small population of glycosylphosphatidylinositol-anchor deficient erythrocytes, 10 patients were detected to harbor glycosylphosphatidylinositol-anchor deficient T lymphocytes, and 3 of them were detected only after T-lymphocyte enrichment in proaerolysin selection. PIG-A mutation analyses on 3 patients showed that all of them harbored a matching PIG-A mutation between CFU-GM and enriched T lymphocytes. Two of 26 myelodysplastic syndromes were found to harbor small populations of glycosylphosphatidylinositol-anchor deficient granulocytes and erythrocytes transiently. Bone marrow derived CD34(+) cells from 4

  14. Stimulated coherent transition radiation

    Energy Technology Data Exchange (ETDEWEB)

    Hung-chi Lihn

    1996-03-01

    Coherent radiation emitted from a relativistic electron bunch consists of wavelengths longer than or comparable to the bunch length. The intensity of this radiation out-numbers that of its incoherent counterpart, which extends to wavelengths shorter than the bunch length, by a factor equal to the number of electrons in the bunch. In typical accelerators, this factor is about 8 to 11 orders of magnitude. The spectrum of the coherent radiation is determined by the Fourier transform of the electron bunch distribution and, therefore, contains information of the bunch distribution. Coherent transition radiation emitted from subpicosecond electron bunches at the Stanford SUNSHINE facility is observed in the far-infrared regime through a room-temperature pyroelectric bolometer and characterized through the electron bunch-length study. To measure the bunch length, a new frequency-resolved subpicosecond bunch-length measuring system is developed. This system uses a far-infrared Michelson interferometer to measure the spectrum of coherent transition radiation through optical autocorrelation with resolution far better than existing time-resolved methods. Hence, the radiation spectrum and the bunch length are deduced from the autocorrelation measurement. To study the stimulation of coherent transition radiation, a special cavity named BRAICER is invented. Far-infrared light pulses of coherent transition radiation emitted from electron bunches are delayed and circulated in the cavity to coincide with subsequent incoming electron bunches. This coincidence of light pulses with electron bunches enables the light to do work on electrons, and thus stimulates more radiated energy. The possibilities of extending the bunch-length measuring system to measure the three-dimensional bunch distribution and making the BRAICER cavity a broadband, high-intensity, coherent, far-infrared light source are also discussed.

  15. The Solution of a Coupled Nonlinear System Arising in a Three-Dimensional Rotating Flow Using Spline Method

    Directory of Open Access Journals (Sweden)

    Jigisha U. Pandya

    2012-01-01

    Full Text Available The behavior of the non-linear-coupled systems arising in axially symmetric hydromagnetics flow between two horizontal plates in a rotating system is analyzed, where the lower is a stretching sheet and upper is a porous solid plate. The equations of conservation of mass and momentum are transformed to a system of coupled nonlinear ordinary differential equations. These equations for the velocity field are solved numerically by using quintic spline collocation method. To solve the nonlinear equation, quasilinearization technique has been used. The numerical results are presented through graphs, in which the effects of viscosity, through flow, magnetic flux, and rotational velocity on velocity field are discussed.

  16. Shock Wave Solutions for Some Nonlinear Flow Models Arising in the Study of a Non-Newtonian Third Grade Fluid

    Directory of Open Access Journals (Sweden)

    Taha Aziz

    2013-01-01

    Full Text Available This study is based upon constructing a new class of closed-form shock wave solutions for some nonlinear problems arising in the study of a third grade fluid model. The Lie symmetry reduction technique has been employed to reduce the governing nonlinear partial differential equations into nonlinear ordinary differential equations. The reduced equations are then solved analytically, and the shock wave solutions are constructed. The conditions on the physical parameters of the flow problems also fall out naturally in the process of the derivation of the solutions.

  17. A Note on the Solutions of Some Nonlinear Equations Arising in Third-Grade Fluid Flows: An Exact Approach

    Science.gov (United States)

    Mahomed, F. M.

    2014-01-01

    In this communication, we utilize some basic symmetry reductions to transform the governing nonlinear partial differential equations arising in the study of third-grade fluid flows into ordinary differential equations. We obtain some simple closed-form steady-state solutions of these reduced equations. Our solutions are valid for the whole domain [0,∞) and also satisfy the physical boundary conditions. We also present the numerical solutions for some of the underlying equations. The graphs corresponding to the essential physical parameters of the flow are presented and discussed. PMID:25143962

  18. Black hole entropy arising from massless scalar field with Lorentz violation induced by the coupling to Einstein tensor

    CERN Document Server

    Chen, Songbai; Liao, Hao

    2015-01-01

    We have investigated quantum entropy of a static black hole arising from the massless scalar field with Lorentz violation induced by the coupling to Einstein tensor. Our results show that the coupled massless scalar field contributes to the classical Bekenstein-Hawking term in the black hole entropy. The corrected classical Bekenstein-Hawking entropy is not one quarter of the event horizon area of the original background black hole, but of a corresponding effective metric related to the coupling. It means that the classical Bekenstein-Hawking entropy depends not only on the black hole parameter, but also on the coupling which reduces Lorentz violation.

  19. A globally convergent matrix-free algorithm for implicit time-marching schemes arising in finite element analysis in fluids

    Science.gov (United States)

    Johan, Zdenek; Hughes, Thomas J. R.; Shakib, Farzin

    1991-01-01

    A solution procedure for solving nonlinear time-marching problems is presented. The nonsymmetric systems of equations arising from a Newton-type linearization of these time-marching problems are solved using an iterative strategy based on the generalized minimal residual (GMRES) algorithm. Matrix-free techniques leading to reduction in storage are presented. Incorporation of a linesearch algorithm in the Newton-GMRES scheme is discussed. An automatic time-increment control strategy is developed to increase the stability of the time-marching process. High-speed flow computations demonstrate the effectiveness of these algorithms.

  20. The Perils of a Defective Medical Communication: Fatal Neglected Squamous Cell Carcinoma Arising in Perineal Hidradenitis Suppurativa

    Directory of Open Access Journals (Sweden)

    Calogero Pagliarello

    2011-01-01

    Full Text Available Hidradenitis suppurativa (HS is a recurrent suppurative disease characterized by inflammatory nodules, abscesses, fistulas, and scarring. We report a case of squamous cell carcinoma arising in chronic HS. In our case the asymptomatic lesion was neglected by the patient for a long time, allowing the occurrence of advanced disease before treatment was sought, which resulted in a terminal outcome. In the context of HS, a painful lump or ulcer could easily be mistaken for an inflammatory lesion, and therefore a low threshold for biopsy is warranted.

  1. Osteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Chintamani

    2011-07-01

    Full Text Available Abstract Introduction Primary tumors of the breast containing bone and cartilage are extremely rare, and an osteogenic sarcoma arising from a cystosarcoma phyllodes is exceptional. Case presentation A 40-year-old Indian woman presented with a breast mass which was diagnosed as osteosarcoma of the breast on biopsy. Our patient was treated with a simple mastectomy after excluding the presence of skeletal primary and extra-mammary metastases. Final pathology showed a cystosarcoma phyllodes with signs of osteogenic sarcoma. Conclusion Although osteogenic sarcomas of the breast are rare, they need to be distinguished from carcinosarcomas and metaplastic carcinomas as the management of the two differ.

  2. Aborted sudden cardiac death in a young male with anomalous left coronary artery arising from the pulmonary artery

    Directory of Open Access Journals (Sweden)

    Chih-Han Huang

    2017-01-01

    Full Text Available Anomalous left coronary artery arising from the pulmonary artery (ALCAPA is a rare type of congenital coronary abnormality that may be associated with early infant mortality and sudden adult cardiac death. We report a case regarding a 23-year-old male who collapsed during a marathon race and was resuscitated with cardiopulmonary resuscitation. Subsequent workups verified the diagnosis of ALCAPA. The patient underwent surgical intervention with obliteration of the ALCAPA orifice and coronary artery bypass grafting with left internal mammary artery to left anterior descending coronary artery. The procedure was done smoothly, and he was discharged uneventfully.

  3. Nephroblastoma Arising in a Primary Testicular Teratoma in a Nonatrophic Testis of a 50-Year-Old Man.

    Science.gov (United States)

    Kromka, Joseph J; Turner, Kevin; Elisco, Anthony; Hale, Nathan

    2018-01-01

    Extrarenal nephroblastoma is an extremely rare tumor thought to be related to teratoid tumors of germ cell origin. Because few cases have been reported, no standard method for categorizing and managing these tumors exists. To our knowledge, there have only been 3 adult cases of nephroblastoma arising in a germ cell tumor of testicular origin in a nonatrophic testis, all in men aged 19 to 22 years and with aggressive clinical courses. We report a case of nephroblastoma in a nonatrophic testis, with nephroblastoma being the only non-germ cell component, in an older patient and with a more indolent clinical course that was responsive to localized treatment.

  4. The Nonlinear Phase Response Curve of the Human Circadian Pacemaker and How Complex Behaviors Might Arise in Nature

    Science.gov (United States)

    Leder, Ron S.

    2002-08-01

    Our example from nature is two groups of about 10,000 cells in the brain called Suprachiasmatic Nuclei (SCN) and how light can entrain free running endogenous periodic behavior via the retina's connection to the SCN. Our major question is how a complex behavior like this can arise in nature. Finally presented is a mathematical model and simulation showing how simple periodic signals can be coupled to produce spatio-temporal chaotic behavior and how two complex signals can combine to produce simple coherent behavior with a hypothetical analogy to phase resetting in biological circadian pacemakers.

  5. The theory of heat radiation

    CERN Document Server

    Planck, Max

    2003-01-01

    Nobel laureate's classic exposition of the theory of radiant heat in terms of quantum action. Kirchoff's law, black radiation, Maxwell's radiation pressure, entropy, other topics. 1914 edition. Bibliography.

  6. Radiation area monitor device and method

    Energy Technology Data Exchange (ETDEWEB)

    Vencelj, Matjaz; Stowe, Ashley C.; Petrovic, Toni; Morrell, Jonathan S.; Kosicek, Andrej

    2018-01-30

    A radiation area monitor device/method, utilizing: a radiation sensor; a rotating radiation shield disposed about the radiation sensor, wherein the rotating radiation shield defines one or more ports that are transparent to radiation; and a processor operable for analyzing and storing a radiation fingerprint acquired by the radiation sensor as the rotating radiation shield is rotated about the radiation sensor. Optionally, the radiation sensor includes a gamma and/or neutron radiation sensor. The device/method selectively operates in: a first supervised mode during which a baseline radiation fingerprint is acquired by the radiation sensor as the rotating radiation shield is rotated about the radiation sensor; and a second unsupervised mode during which a subsequent radiation fingerprint is acquired by the radiation sensor as the rotating radiation shield is rotated about the radiation sensor, wherein the subsequent radiation fingerprint is compared to the baseline radiation fingerprint and, if a predetermined difference threshold is exceeded, an alert is issued.

  7. Foundations of radiation hydrodynamics

    CERN Document Server

    Mihalas, Dimitri

    1999-01-01

    Radiation hydrodynamics is a broad subject that cuts across many disciplines in physics and astronomy: fluid dynamics, thermodynamics, statistical mechanics, kinetic theory, and radiative transfer, among others. The theory developed in this book by two specialists in the field can be applied to the study of such diverse astrophysical phenomena as stellar winds, supernova explosions, and the initial phases of cosmic expansion, as well as the physics of laser fusion and reentry vehicles. As such, it provides students with the basic tools for research on radiating flows.Largely self-contained,

  8. Radiation hormesis in plant

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Sung; Song, Hi Sup; Lee, Young Keun; Cun, Ki Jung; Shin, In Chul; Lim, Young Taek

    1999-04-01

    This research was performed to investigate the effects of low dose {gamma}-ray radiation on the seed germination and the following physiological responses in vegetable crops. Special attention was focused on whether the resistance of vegetables against the unfavorable conditions of environment such as acid rain or soil types could be enhanced as an aspect of radiation hormesis. Analysis and characterization of antioxidant enzyme from plant culture cells and radiation tolerant of transformed plants from antioxidant enzyme (POD) were accomplished in the plant irradiated with difference dosage of {gamma}-ray.

  9. Radiation therapy in horses.

    Science.gov (United States)

    Fidel, Janean L

    2010-04-01

    Although the diagnosis of cancer is relatively uncommon in horses, tumors do occur in this species. Surgery, radiation, and chemotherapy are traditional cancer treatments in all species. In equine patients, surgery has often been the only treatment offered; however, not all tumors can be controlled with surgery alone. In small animal oncology, newer and better therapies are in demand and available. Radiation therapy is often used to control or palliate tumors locally, especially to satisfy clients who demand sophisticated treatments. The large size of equine patients can make radiation therapy difficult, but it is a valuable tool for treating cancer and should not be overlooked when treating horses.

  10. Nuclear medicine radiation dosimetry

    CERN Document Server

    McParland, Brian J

    2010-01-01

    Complexities of the requirements for accurate radiation dosimetry evaluation in both diagnostic and therapeutic nuclear medicine (including PET) have grown over the past decade. This is due primarily to four factors: growing consideration of accurate patient-specific treatment planning for radionuclide therapy as a means of improving the therapeutic benefit, development of more realistic anthropomorphic phantoms and their use in estimating radiation transport and dosimetry in patients, design and use of advanced Monte Carlo algorithms in calculating the above-mentioned radiation transport and

  11. Ethics and radiation protection.

    Science.gov (United States)

    Hansson, Sven Ove

    2007-06-01

    Some of the major problems in radiation protection are closely connected to issues that have a long, independent tradition in moral philosophy. This contribution focuses on two of these issues. One is the relationship between the protection of individuals and optimisation on the collective level, and the other is the relative valuation of future versus immediate damage. Some of the intellectual tools that have been developed by philosophers can be useful in radiation protection. On the other hand, philosophers have much to learn from radiation protectors, not least when it comes to finding pragmatic solutions to problems that may be intractable in principle.

  12. SSC workshop on environmental radiation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-01-09

    The Superconducting Super Collider is a 20 TeV-on-20 TeV proton beam collider where two 20-TeV proton accelerators whose beams, rotating in opposite senses, are brought into collision to provide 40 TeV in the center of mass. The scale of the project is set by the 6.6 tesla magnet guide field for the protons which results in a roughly circular machine with a circumference of 83 km (51.5 mi.). The energy scale of the proton beams and the physical scale of the machine are an order of magnitude greater than for any presently operating or contemplated proton accelerator yet the facility must be operated within the same strict radiological guidelines as existing accelerators in the US and Europe. To ensure that the facility conforms to existing and projected guidelines both in design and operation, the Workshop was charged to review the experience and practices of existing accelerator laboratories, to determine the relevant present and projected regulatory requirements, to review particle production and shielding data from accelerators and cosmic rays, to study the design and operational specifications of the Collider, to examine the parameters set forth in the Siting Parameters Document, and to evaluate the computational tools available to model the radiation patterns arising under various operational and failure scenarios. This report summarizes the extensive and intensive presentations and discussions of the Workshop. A great deal of material, much of it in the form of internal reports from the various laboratories and drafts of works in preparation, was provided by the participants for the various topics. This material, including the viewgraphs used by the presenters, forms the background and basis for the conclusions of the Workshop and, as such, is an important part of the Workshop. An introduction to the material and a catalog by topic are presented as section 6 of this report.

  13. RADIATIVELY EFFICIENT MAGNETIZED BONDI ACCRETION

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, Andrew J.; Klein, Richard I. [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); McKee, Christopher F. [Department of Astronomy, University of California Berkeley, Berkeley, CA 94720 (United States); Krumholz, Mark R. [Department of Astronomy and Astrophysics, University of California Santa Cruz, Santa Cruz, CA 94560 (United States); Teyssier, Romain, E-mail: ajcunn@gmail.com [Service d' Astrophysique, CEA Saclay, 91191 Gif-sur-Yvette (France)

    2012-01-10

    We have carried out a numerical study of the effect of large-scale magnetic fields on the rate of accretion from a uniform, isothermal gas onto a resistive, stationary point mass. Only mass, not magnetic flux, accretes onto the point mass. The simulations for this study avoid complications arising from boundary conditions by keeping the boundaries far from the accreting object. Our simulations leverage adaptive refinement methodology to attain high spatial fidelity close to the accreting object. Our results are particularly relevant to the problem of star formation from a magnetized molecular cloud in which thermal energy is radiated away on timescales much shorter than the dynamical timescale. Contrary to the adiabatic case, our simulations show convergence toward a finite accretion rate in the limit in which the radius of the accreting object vanishes, regardless of magnetic field strength. For very weak magnetic fields, the accretion rate first approaches the Bondi value and then drops by a factor of {approx}2 as magnetic flux builds up near the point mass. For strong magnetic fields, the steady-state accretion rate is reduced by a factor of {approx}0.2 {beta}{sup 1/2} compared to the Bondi value, where {beta} is the ratio of the gas pressure to the magnetic pressure. We give a simple expression for the accretion rate as a function of the magnetic field strength. Approximate analytic results are given in the Appendices for both time-dependent accretion in the limit of weak magnetic fields and steady-state accretion for the case of strong magnetic fields.

  14. Self-consistent radiative corrections to false vacuum decay

    Science.gov (United States)

    Garbrecht, B.; Millington, P.

    2017-07-01

    With the Higgs mass now measured at the sub-percent level, the potential metastability of the electroweak vacuum of the Standard Model (SM) motivates renewed study of false vacuum decay in quantum field theory. In this note, we describe an approach to calculating quantum corrections to the decay rate of false vacua that is able to account fully and self-consistently for the underlying inhomogeneity of the solitonic tunneling configuration. We show that this method can be applied both to theories in which the instability arises already at the level of the classical potential and those in which the instability arises entirely through radiative effects, as is the case for the SM Higgs vacuum. We analyse two simple models in the thin-wall regime, and we show that the modifications of the one-loop corrections from accounting fully for the inhomogeneity can compete at the same level as the two-loop homogeneous corrections.

  15. Mathematical modelling of the the processes of radiating formation of defects at interaction of carbon with graphite

    Directory of Open Access Journals (Sweden)

    A. Kupchishin

    2012-12-01

    Full Text Available Processes of radiation formation of defects in the carbon irradiated by graphite are considered in work. The regularities arising at selection of approximation expressions, a finding of result area at calculation of cascadely - probabilistic functions depending on number of interactions and depth of penetration of particles are revealed. The regularities formed at calculations of concentration of radiating defects in graphite, irradiated by carbon are received. Results of calculations are presented in the form of tables and schedules.

  16. virtX: a CBT-system for mobile image intensifier systems to improve the radiation protection training

    OpenAIRE

    Dresing, Klaus; Stürmer, Klaus Michael; Plischke, Maik; Ahrens, Christoph Alexander; Duwenkamp, Christopher; Wagner, Markus; Bott, Oliver Johannes

    2009-01-01

    Background and objectives: The exposure of patient and personal produced by diagnostic medical X-ray techniques should be kept at a minimum according to governmental regulations like the Strahlenschutzverordnung in Germany. To achieve this, a professional and prudent use of the X-ray machine is indispensable. Currently this behavior is only taught theoretically, because training with real radiation is not an option. Therefore the question arises how the education in radiation protection can ...

  17. The Integrated Radiation Mapper Assistant

    Energy Technology Data Exchange (ETDEWEB)

    Carlton, R.E.; Tripp, L.R. [Odetics, Inc., Anaheim, CA (United States)

    1995-03-01

    The Integrated Radiation Mapper Assistant (IRMA) system combines state-of-the-art radiation sensors and microprocessor based analysis techniques to perform radiation surveys. Control of the survey function is from a control station located outside the radiation thus reducing time spent in radiation areas performing radiation surveys. The system consists of a directional radiation sensor, a laser range finder, two area radiation sensors, and a video camera mounted on a pan and tilt platform. THis sensor package is deployable on a remotely operated vehicle. The outputs of the system are radiation intensity maps identifying both radiation source intensities and radiation levels throughout the room being surveyed. After completion of the survey, the data can be removed from the control station computer for further analysis or archiving.

  18. BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus.

    Science.gov (United States)

    Tan, Jean-Marie; Lin, Lynlee L; Lambie, Duncan; Flewell-Smith, Ross; Jagirdar, Kasturee; Schaider, Helmut; Sturm, Richard A; Prow, Tarl W; Soyer, H Peter

    2015-04-01

    The BRAF V600E mutation accounts for the majority of BRAF mutations found in cutaneous melanoma and is also commonly found in nevi. We used dermoscopy-targeted sampling and a microbiopsy device coupled with DNA sequence analysis to highlight BRAF V600E heterogeneity within a multicomponent melanocytic proliferation. This sampling technique demonstrates the prospect of in vivo application in a clinical setting. A man in his 50s with Fitzpatrick skin type II presented with an irregularly pigmented melanocytic lesion on his back that met melanoma-specific dermoscopic criteria, and diagnostic shave excision of the lesion was performed. Histopathologic analysis revealed a melanoma in situ arising in a dysplastic nevus. Dermoscopy-targeted microbiopsy specimens were taken across the lesion, and genotyping was carried out on extracted DNA samples for BRAF and NRAS mutations. The melanoma in situ showed only BRAF wild-type results, while the dysplastic nevus showed both BRAF wild-type and BRAF V600E mutations. Sequencing in all DNA samples revealed NRAS wild-type genotype. Dermoscopy-targeted sampling and genotyping of a melanoma in situ arising in a dysplastic nevus revealed a phenotype-genotype paradox that confounds the exclusive significance of BRAF and NRAS mutations in melanoma pathogenesis. Further studies are required to investigate the importance of other candidate genes linked to melanomagenesis.

  19. Controlling Rescattering Effects in Constraints on the CKM Angle $\\gamma$ arising from $B\\to\\pi K$ Decays

    CERN Document Server

    Fleischer, Robert

    1998-01-01

    It has recently been pointed out that the observables of the decay $B^+\\to K^+\\bar{K^0}$ and its charge conjugate allow us to take into account rescattering effects in constraints on the CKM angle $\\gamma$ arising from $B^\\pm\\to\\pi^\\pm K$ and $B_d\\to\\pi^\\pm K^\\pm$ modes, and that they play an important role to obtain insights into final-state interactions. In this paper, the formalism needed to accomplish this task is discussed in detail. Furthermore, using a transparent model to describe the rescattering processes, as well as electroweak penguins, we calculate the quantities parametrizing the $B^+\\to\\pi^+ K^0$ and $B_d^0\\to\\pi^- K^+$ decay amplitudes for specific examples, and illustrate the constraints on $\\gamma$ arising from the corresponding observables. Although this model is very crude, it shows nicely the power of $B^\\pm\\to K^\\pm K$ both to include the rescattering effects in the bounds on $\\gamma$ and to obtain insights into final-state interactions. Moreover this model exhibits the interesting featu...

  20. Spectral-analysis-based extraction of land disturbances arising from oil and gas development in diverse landscapes

    Science.gov (United States)

    Zhang, Ying; Lantz, Nicholas; Guindon, Bert; Jiao, Xianfen

    2017-01-01

    Accurate and frequent monitoring of land surface changes arising from oil and gas exploration and extraction is a key requirement for the responsible and sustainable development of these resources. Petroleum deposits typically extend over large geographic regions but much of the infrastructure required for oil and gas recovery takes the form of numerous small-scale features (e.g., well sites, access roads, etc.) scattered over the landscape. Increasing exploitation of oil and gas deposits will increase the presence of these disturbances in heavily populated regions. An object-based approach is proposed to utilize RapidEye satellite imagery to delineate well sites and related access roads in diverse complex landscapes, where land surface changes also arise from other human activities, such as forest logging and agriculture. A simplified object-based change vector approach, adaptable to operational use, is introduced to identify the disturbances on land based on red-green spectral response and spatial attributes of candidate object size and proximity to roads. Testing of the techniques has been undertaken with RapidEye multitemporal imagery in two test sites located at Alberta, Canada: one was a predominant natural forest landscape and the other landscape dominated by intensive agricultural activities. Accuracies of 84% and 73%, respectively, have been achieved for the identification of well site and access road infrastructure of the two sites based on fully automated processing. Limited manual relabeling of selected image segments can improve these accuracies to 95%.