WorldWideScience

Sample records for vascular transport systems

  1. Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection

    Directory of Open Access Journals (Sweden)

    Chanettee Chanthick

    2018-02-01

    Full Text Available The major role of endothelial cells is to maintain homeostasis of vascular permeability and to preserve the integrity of vascular vessels to prevent fluid leakage. Properly functioning endothelial cells promote physiological balance and stability for blood circulation and fluid components. A monolayer of endothelial cells has the ability to regulate paracellular and transcellular pathways for transport proteins, solutes, and fluid. In addition to the paracellular pathway, the transcellular pathway is another route of endothelial permeability that mediates vascular permeability under physiologic conditions. The transcellular pathway was found to be associated with an assortment of disease pathogeneses. The clinical manifestation of severe dengue infection in humans is vascular leakage and hemorrhagic diatheses. This review explores and describes the transcellular pathway, which is an alternate route of vascular permeability during dengue infection that corresponds with the pathologic finding of intact tight junction. This pathway may be the route of albumin transport that causes endothelial dysfunction during dengue virus infection.

  2. The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems.

    Science.gov (United States)

    Wu, Min; Frieboes, Hermann B; Chaplain, Mark A J; McDougall, Steven R; Cristini, Vittorio; Lowengrub, John S

    2014-08-21

    Vascularized tumor growth is characterized by both abnormal interstitial fluid flow and the associated interstitial fluid pressure (IFP). Here, we study the effect that these conditions have on the transport of therapeutic agents during chemotherapy. We apply our recently developed vascular tumor growth model which couples a continuous growth component with a discrete angiogenesis model to show that hypertensive IFP is a physical barrier that may hinder vascular extravasation of agents through transvascular fluid flux convection, which drives the agents away from the tumor. This result is consistent with previous work using simpler models without blood flow or lymphatic drainage. We consider the vascular/interstitial/lymphatic fluid dynamics to show that tumors with larger lymphatic resistance increase the agent concentration more rapidly while also experiencing faster washout. In contrast, tumors with smaller lymphatic resistance accumulate less agents but are able to retain them for a longer time. The agent availability (area-under-the curve, or AUC) increases for less permeable agents as lymphatic resistance increases, and correspondingly decreases for more permeable agents. We also investigate the effect of vascular pathologies on agent transport. We show that elevated vascular hydraulic conductivity contributes to the highest AUC when the agent is less permeable, but to lower AUC when the agent is more permeable. We find that elevated interstitial hydraulic conductivity contributes to low AUC in general regardless of the transvascular agent transport capability. We also couple the agent transport with the tumor dynamics to simulate chemotherapy with the same vascularized tumor under different vascular pathologies. We show that tumors with an elevated interstitial hydraulic conductivity alone require the strongest dosage to shrink. We further show that tumors with elevated vascular hydraulic conductivity are more hypoxic during therapy and that the response

  3. Transport system

    NARCIS (Netherlands)

    Drenth, K.F.

    1999-01-01

    The transport system comprises at least one road surface (2) and at least one vehicle (4) on wheels (6). The road surface (2) has a substantially bowl-shaped cross section and the vehicle (4) is designed so that the wheels (6) run directly on the road surface (2) while the road surface (2) acts as a

  4. FPGA controlled artificial vascular system

    Directory of Open Access Journals (Sweden)

    Laqua D.

    2015-09-01

    Full Text Available Monitoring the oxygen saturation of an unborn child is an invasive procedure, so far. Transabdominal fetal pulse oximetry is a promising method under research, used to estimate the oxygen saturation of a fetus noninvasively. Due to the nature of the method, the fetal information needs to be extracted from a mixed signal. To properly evaluate signal processing algorithms, a phantom modeling fetal and maternal blood circuits and tissue layers is necessary. This paper presents an improved hardware concept for an artificial vascular system, utilizing an FPGA based CompactRIO System from National Instruments. The experimental model to simulate the maternal and fetal blood pressure curve consists of two identical hydraulic circuits. Each of these circuits consists of a pre-pressure system and an artificial vascular system. Pulse curves are generated by proportional valves, separating these two systems. The dilation of the fetal and maternal artificial vessels in tissue substitutes is measured by transmissive and reflective photoplethysmography. The measurement results from the pressure sensors and the transmissive optical sensors are visualized to show the functionality of the pulse generating systems. The trigger frequency for the maternal valve was set to 1 per second, the fetal valve was actuated at 0.7 per second for validation. The reflective curve, capturing pulsations of the fetal and maternal circuit, was obtained with a high power LED (905 nm as light source. The results show that the system generates pulse curves, similar to its physiological equivalent. Further, the acquired reflective optical signal is modulated by the alternating diameter of the tubes of both circuits, allowing for tests of signal processing algorithms.

  5. Pediatric central nervous system vascular malformations

    International Nuclear Information System (INIS)

    Burch, Ezra A.; Orbach, Darren B.

    2015-01-01

    Pediatric central nervous system (CNS) vascular anomalies include lesions found only in the pediatric population and also the full gamut of vascular lesions found in adults. Pediatric-specific lesions discussed here include infantile hemangioma, vein of Galen malformation and dural sinus malformation. Some CNS vascular lesions that occur in adults, such as arteriovenous malformation, have somewhat distinct manifestations in children, and those are also discussed. Additionally, children with CNS vascular malformations often have associated broader vascular conditions, e.g., PHACES (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, eye anomalies and sternal anomalies), hereditary hemorrhagic telangiectasia, and capillary malformation-arteriovenous malformation syndrome (related to the RASA1 mutation). The treatment of pediatric CNS vascular malformations has greatly benefited from advances in endovascular therapy, including technical advances in adult interventional neuroradiology. Dramatic advances in therapy are expected to stem from increased understanding of the genetics and vascular biology that underlie pediatric CNS vascular malformations. (orig.)

  6. Pediatric central nervous system vascular malformations

    Energy Technology Data Exchange (ETDEWEB)

    Burch, Ezra A. [Brigham and Women' s Hospital, Department of Radiology, Boston, MA (United States); Orbach, Darren B. [Boston Children' s Hospital, Neurointerventional Radiology, Boston, MA (United States)

    2015-09-15

    Pediatric central nervous system (CNS) vascular anomalies include lesions found only in the pediatric population and also the full gamut of vascular lesions found in adults. Pediatric-specific lesions discussed here include infantile hemangioma, vein of Galen malformation and dural sinus malformation. Some CNS vascular lesions that occur in adults, such as arteriovenous malformation, have somewhat distinct manifestations in children, and those are also discussed. Additionally, children with CNS vascular malformations often have associated broader vascular conditions, e.g., PHACES (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, eye anomalies and sternal anomalies), hereditary hemorrhagic telangiectasia, and capillary malformation-arteriovenous malformation syndrome (related to the RASA1 mutation). The treatment of pediatric CNS vascular malformations has greatly benefited from advances in endovascular therapy, including technical advances in adult interventional neuroradiology. Dramatic advances in therapy are expected to stem from increased understanding of the genetics and vascular biology that underlie pediatric CNS vascular malformations. (orig.)

  7. Investigating water transport through the xylem network in vascular plants.

    Science.gov (United States)

    Kim, Hae Koo; Park, Joonghyuk; Hwang, Ildoo

    2014-04-01

    Our understanding of physical and physiological mechanisms depends on the development of advanced technologies and tools to prove or re-evaluate established theories, and test new hypotheses. Water flow in land plants is a fascinating phenomenon, a vital component of the water cycle, and essential for life on Earth. The cohesion-tension theory (CTT), formulated more than a century ago and based on the physical properties of water, laid the foundation for our understanding of water transport in vascular plants. Numerous experimental tools have since been developed to evaluate various aspects of the CTT, such as the existence of negative hydrostatic pressure. This review focuses on the evolution of the experimental methods used to study water transport in plants, and summarizes the different ways to investigate the diversity of the xylem network structure and sap flow dynamics in various species. As water transport is documented at different scales, from the level of single conduits to entire plants, it is critical that new results be subjected to systematic cross-validation and that findings based on different organs be integrated at the whole-plant level. We also discuss the functional trade-offs between optimizing hydraulic efficiency and maintaining the safety of the entire transport system. Furthermore, we evaluate future directions in sap flow research and highlight the importance of integrating the combined effects of various levels of hydraulic regulation.

  8. Imaging of the peripheral vascular system

    International Nuclear Information System (INIS)

    Gould, S.A.; Pond, G.D.; Pinsky, S.; Moss, G.S.; Srikantaswamy, S.; Ryo, U.Y.

    1984-01-01

    This book is limited neither to the peripheral vascular system nor to diagnostic imaging techniques. Its 18 chapters cover nonimaging blood-flow techniques (Doppler ultrasound, plethysmography) as well as noninvasive and invasive imaging techniques (ultrasound, computed tomography, radionuclide digital-subtraction angiography, and contrast angiography). These are applied not only to the peripheral vascular system but also to the aorta and vena cava

  9. Transportation System Requirements Document

    International Nuclear Information System (INIS)

    1993-09-01

    This Transportation System Requirements Document (Trans-SRD) describes the functions to be performed by and the technical requirements for the Transportation System to transport spent nuclear fuel (SNF) and high-level radioactive waste (HLW) from Purchaser and Producer sites to a Civilian Radioactive Waste Management System (CRWMS) site, and between CRWMS sites. The purpose of this document is to define the system-level requirements for Transportation consistent with the CRWMS Requirement Document (CRD). These requirements include design and operations requirements to the extent they impact on the development of the physical segments of Transportation. The document also presents an overall description of Transportation, its functions, its segments, and the requirements allocated to the segments and the system-level interfaces with Transportation. The interface identification and description are published in the CRWMS Interface Specification

  10. Optimal concentrations in transport systems

    Science.gov (United States)

    Jensen, Kaare H.; Kim, Wonjung; Holbrook, N. Michele; Bush, John W. M.

    2013-01-01

    Many biological and man-made systems rely on transport systems for the distribution of material, for example matter and energy. Material transfer in these systems is determined by the flow rate and the concentration of material. While the most concentrated solutions offer the greatest potential in terms of material transfer, impedance typically increases with concentration, thus making them the most difficult to transport. We develop a general framework for describing systems for which impedance increases with concentration, and consider material flow in four different natural systems: blood flow in vertebrates, sugar transport in vascular plants and two modes of nectar drinking in birds and insects. The model provides a simple method for determining the optimum concentration copt in these systems. The model further suggests that the impedance at the optimum concentration μopt may be expressed in terms of the impedance of the pure (c = 0) carrier medium μ0 as μopt∼2αμ0, where the power α is prescribed by the specific flow constraints, for example constant pressure for blood flow (α = 1) or constant work rate for certain nectar-drinking insects (α = 6). Comparing the model predictions with experimental data from more than 100 animal and plant species, we find that the simple model rationalizes the observed concentrations and impedances. The model provides a universal framework for studying flows impeded by concentration, and yields insight into optimization in engineered systems, such as traffic flow. PMID:23594815

  11. Intelligent Freigth Transport Systems

    DEFF Research Database (Denmark)

    Overø, Helene Martine; Larsen, Allan; Røpke, Stefan

    2009-01-01

    is to enhance the efficiency and lower the environmental impact in freight transport. In this paper, a pilot project involving real-time waste collection at a Danish waste collection company is described, and a solution approach is proposed. The problem corresponds to the dynamic version of the waste collection......The Danish innovation project entitled “Intelligent Freight Transport Systems” aims at developing prototype systems integrating public intelligent transport systems (ITS) with the technology in vehicles and equipment as well as the IT-systems at various transport companies. The objective...

  12. TRANSPORTATION SYSTEM REQUIREMENTS DOCUMENT

    International Nuclear Information System (INIS)

    2004-01-01

    This document establishes the Transportation system requirements for the U.S. Department of Energy's (DOE's) Civilian Radioactive Waste Management System (CRWMS). These requirements are derived from the Civilian Radioactive Waste Management System Requirements Document (CRD). The Transportation System Requirements Document (TSRD) was developed in accordance with LP-3.1Q-OCRWM, Preparation, Review, and Approval of Office of National Transportation Level-2 Baseline Requirements. As illustrated in Figure 1, the TSRD forms a part of the DOE Office of Civilian Radioactive Waste Management (OCRWM) Technical Baseline

  13. Electrical railway transportation systems

    CERN Document Server

    Brenna, Morris; Zaninelli, Dario

    2018-01-01

    Allows the reader to deepen their understanding of various technologies for both fixed power supply installations of railway systems and for railway rolling stock. This book explores the electric railway systems that play a crucial role in the mitigation of congestion and pollution caused by road traffic. It is divided into two parts: the first covering fixed power supply systems, and the second concerning the systems for railway rolling stock. In particular, after a historical introduction to the framework of technological solutions in current use, the authors investigate electrification systems for the power supply of rail vehicles, trams, and subways. Electrical Railway Transportation Systems explores the direct current systems used throughout the world for urban and suburban transport, which are also used in various countries for regional transport. It provides a study of alternating current systems, whether for power supply frequency or for special railway frequency, that are used around the world for ...

  14. Lightweight Monorail Transport System

    Science.gov (United States)

    Weir, Harold F.; Wood, Kenneth E.; Strecker, Myron T.

    1987-01-01

    Report proposes monorail transportation system for zero-gravity environment. System carries materials and parts between locations on space station. Includes tubular rails instead of open channels usually found in overhead conveyor systems. Since resistance to torque of closed tube greater than that of open channel for same amount of material, tubular monorail designed for higher loads or for greater spacing between support points.

  15. Transportable criticality alarm system

    International Nuclear Information System (INIS)

    Clem, W.E.

    1988-09-01

    The Transportable Criticality Alarm System was developed at the Hanford Site in 1982 to comply with the requirements of US Department of Energy Order DOE 5480.1, 12/18/80, and ANSI/ANS-8.3- 1979. The portable unit that it replaced failed to comply with the new requirements in that it did not provide the necessary warning of malfunctions, nor did it provide the Hanford Site standard criticality alarm signal. Modern technology allowed the Transportable Criticality Alarm System to comply with the criticality requirements cited and to incorporate other features that make it more usable, maintainable, and reliable. The Transportable Criticality Alarm System (TCAS) provides temporary criticality coverage in manned areas where the facility criticality alarm system is not operable. This gamma radiation-sensitive system has been in use for the past 6 yr at the Hanford Site. 2 refs., 4 figs., 1 tab

  16. Update on vascular endothelial Ca(2+) signalling: A tale of ion channels, pumps and transporters.

    Science.gov (United States)

    Moccia, Francesco; Berra-Romani, Roberto; Tanzi, Franco

    2012-07-26

    A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a multifunctional transducing organ that mediates a plethora of cardiovascular processes. The activation of ECs from as state of quiescence is, therefore, regarded among the early events leading to the onset and progression of potentially lethal diseases, such as hypertension, myocardial infarction, brain stroke, and tumor. Intracellular Ca(2+) signals have long been know to play a central role in the complex network of signaling pathways regulating the endothelial functions. Notably, recent work has outlined how any change in the pattern of expression of endothelial channels, transporters and pumps involved in the modulation of intracellular Ca(2+) levels may dramatically affect whole body homeostasis. Vascular ECs may react to both mechanical and chemical stimuli by generating a variety of intracellular Ca(2+) signals, ranging from brief, localized Ca(2+) pulses to prolonged Ca(2+) oscillations engulfing the whole cytoplasm. The well-defined spatiotemporal profile of the subcellular Ca(2+) signals elicited in ECs by specific extracellular inputs depends on the interaction between Ca(2+) releasing channels, which are located both on the plasma membrane and in a number of intracellular organelles, and Ca(2+) removing systems. The present article aims to summarize both the past and recent literature in the field to provide a clear-cut picture of our current knowledge on the molecular nature and the role played by the components of the Ca(2+) machinery in vascular ECs under both physiological and pathological conditions.

  17. Update on vascular endothelial Ca2+ signalling: A tale of ion channels, pumps and transporters

    Science.gov (United States)

    Moccia, Francesco; Berra-Romani, Roberto; Tanzi, Franco

    2012-01-01

    A monolayer of endothelial cells (ECs) lines the lumen of blood vessels and forms a multifunctional transducing organ that mediates a plethora of cardiovascular processes. The activation of ECs from as state of quiescence is, therefore, regarded among the early events leading to the onset and progression of potentially lethal diseases, such as hypertension, myocardial infarction, brain stroke, and tumor. Intracellular Ca2+ signals have long been know to play a central role in the complex network of signaling pathways regulating the endothelial functions. Notably, recent work has outlined how any change in the pattern of expression of endothelial channels, transporters and pumps involved in the modulation of intracellular Ca2+ levels may dramatically affect whole body homeostasis. Vascular ECs may react to both mechanical and chemical stimuli by generating a variety of intracellular Ca2+ signals, ranging from brief, localized Ca2+ pulses to prolonged Ca2+ oscillations engulfing the whole cytoplasm. The well-defined spatiotemporal profile of the subcellular Ca2+ signals elicited in ECs by specific extracellular inputs depends on the interaction between Ca2+ releasing channels, which are located both on the plasma membrane and in a number of intracellular organelles, and Ca2+ removing systems. The present article aims to summarize both the past and recent literature in the field to provide a clear-cut picture of our current knowledge on the molecular nature and the role played by the components of the Ca2+ machinery in vascular ECs under both physiological and pathological conditions. PMID:22905291

  18. Systemic Multiple Aneurysms Caused by Vascular Ehlers-Danlos Syndrome.

    Science.gov (United States)

    Gui, Xinyu; Li, Fangda; Wu, Lingeer; Zheng, Yuehong

    2016-07-01

    Systemic multiple aneurysms are rare and usually associated with collagen tissue disease, such as Ehlers-Danlos syndrome (EDS) or Marfan syndrome. In the present case, we describe a 39-year-old male patient with systemic multiple aneurysms and acute intraperitoneal hemorrhage who was clinically diagnosed with vascular EDS. Coil embolization of the distal segment of the common hepatic artery was performed, which resolved the patient's symptoms. With this case presentation, we aim to increase the awareness of vascular EDS among clinicians and emphasize the extreme fragility of the arteries in patients with vascular EDS. © The Author(s) 2016.

  19. Blood Sample Transportation by Pneumatic Transportation Systems

    DEFF Research Database (Denmark)

    Nybo, Mads; Lund, Merete E; Titlestad, Kjell

    2018-01-01

    BACKGROUND: Pneumatic transportation systems (PTSs) are increasingly used for transportation of blood samples to the core laboratory. Many studies have investigated the impact of these systems on different types of analyses, but to elucidate whether PTSs in general are safe for transportation...... analysis, and the hemolysis index). CONCLUSIONS: Owing to their high degree of heterogeneity, the retrieved studies were unable to supply evidence for the safety of using PTSs for blood sample transportation. In consequence, laboratories need to measure and document the actual acceleration forces...

  20. Lunar transportation system

    Science.gov (United States)

    1993-07-01

    The University Space Research Association (USRA) requested the University of Minnesota Spacecraft Design Team to design a lunar transportation infrastructure. This task was a year long design effort culminating in a complete conceptual design and presentation at Johnson Space Center. The mission objective of the design group was to design a system of vehicles to bring a habitation module, cargo, and crew to the lunar surface from LEO and return either or both crew and cargo safely to LEO while emphasizing component commonality, reusability, and cost effectiveness. During the course of the design, the lunar transportation system (LTS) has taken on many forms. The final design of the system is composed of two vehicles, a lunar transfer vehicle (LTV) and a lunar excursion vehicle (LEV). The LTV serves as an efficient orbital transfer vehicle between the earth and the moon while the LEV carries crew and cargo to the lunar surface. Presented in the report are the mission analysis, systems layout, orbital mechanics, propulsion systems, structural and thermal analysis, and crew systems, avionics, and power systems for this lunar transportation concept.

  1. Rail transport systems approach

    CERN Document Server

    2017-01-01

    This book shows how the systems approach is employed by scientists in various countries to solve specific problems concerning railway transport. In particular, the book describes the experiences of scientists from Romania, Germany, the Czech Republic, the UK, Russia, Ukraine, Lithuania and Poland. For many of these countries there is a problem with the historical differences between the railways. In particular, there are railways with different rail gauges, with different signaling and communication systems, with different energy supplies and, finally, with different political systems, which are reflected in the different approaches to the management of railway economies. The book’s content is divided into two main parts, the first of which provides a systematic analysis of individual means of providing and maintaining rail transport. In turn, the second part addresses infrastructure and management development, with particular attention to security issues. Though primarily written for professionals involved...

  2. Heat transport system

    International Nuclear Information System (INIS)

    Pierce, B.L.

    1978-01-01

    A heat transport system of small size which can be operated in any orientation consists of a coolant loop containing a vaporizable liquid as working fluid and includes in series a vaporizer, a condenser and two one-way valves and a pressurizer connected to the loop between the two valves. The pressurizer may be divided into two chambers by a flexible diaphragm, an inert gas in one chamber acts as a pneumatic spring for the system. This system is suitable for use in a nuclear-powered artificial heart

  3. SUBSURFACE EMPLACEMENT TRANSPORTATION SYSTEM

    International Nuclear Information System (INIS)

    Wilson, T.; Novotny, R.

    1999-01-01

    The objective of this analysis is to identify issues and criteria that apply to the design of the Subsurface Emplacement Transportation System (SET). The SET consists of the track used by the waste package handling equipment, the conductors and related equipment used to supply electrical power to that equipment, and the instrumentation and controls used to monitor and operate those track and power supply systems. Major considerations of this analysis include: (1) Operational life of the SET; (2) Geometric constraints on the track layout; (3) Operating loads on the track; (4) Environmentally induced loads on the track; (5) Power supply (electrification) requirements; and (6) Instrumentation and control requirements. This analysis will provide the basis for development of the system description document (SDD) for the SET. This analysis also defines the interfaces that need to be considered in the design of the SET. These interfaces include, but are not limited to, the following: (1) Waste handling building; (2) Monitored Geologic Repository (MGR) surface site layout; (3) Waste Emplacement System (WES); (4) Waste Retrieval System (WRS); (5) Ground Control System (GCS); (6) Ex-Container System (XCS); (7) Subsurface Electrical Distribution System (SED); (8) MGR Operations Monitoring and Control System (OMC); (9) Subsurface Facility System (SFS); (10) Subsurface Fire Protection System (SFR); (11) Performance Confirmation Emplacement Drift Monitoring System (PCM); and (12) Backfill Emplacement System (BES)

  4. Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis

    Directory of Open Access Journals (Sweden)

    Pier Andrea Nicolosi

    2016-01-01

    Full Text Available Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc. The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled with deficient angiogenesis leads to chronic hypoxia and tissue ischemia, enforcing a positive feed-forward loop sustaining vascular remodelling, further exacerbated by extracellular matrix accumulation due to fibrosis. Despite numerous developments and a growing number of controlled clinical trials no treatment has been shown so far to alter SSc natural history, outlining the need of further investigation in the molecular pathways involved in the pathogenesis of the disease. We review some processes potentially involved in SSc vasculopathy, with attention to the possible effect of sustained vascular inflammation on the plasticity of vascular cells. Specifically we focus on mesenchymal transition, a key phenomenon in the cardiac and vascular development as well as in the remodelling of injured vessels. Recent work supports the role of transforming growth factor-beta, Wnt, and Notch signaling in these processes. Importantly, endothelial-mesenchymal transition may be reversible, possibly offering novel cues for treatment.

  5. The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia.

    Science.gov (United States)

    Zhao, Lan; Oliver, Eduardo; Maratou, Klio; Atanur, Santosh S; Dubois, Olivier D; Cotroneo, Emanuele; Chen, Chien-Nien; Wang, Lei; Arce, Cristina; Chabosseau, Pauline L; Ponsa-Cobas, Joan; Frid, Maria G; Moyon, Benjamin; Webster, Zoe; Aldashev, Almaz; Ferrer, Jorge; Rutter, Guy A; Stenmark, Kurt R; Aitman, Timothy J; Wilkins, Martin R

    2015-08-20

    The typical response of the adult mammalian pulmonary circulation to a low oxygen environment is vasoconstriction and structural remodelling of pulmonary arterioles, leading to chronic elevation of pulmonary artery pressure (pulmonary hypertension) and right ventricular hypertrophy. Some mammals, however, exhibit genetic resistance to hypoxia-induced pulmonary hypertension. We used a congenic breeding program and comparative genomics to exploit this variation in the rat and identified the gene Slc39a12 as a major regulator of hypoxia-induced pulmonary vascular remodelling. Slc39a12 encodes the zinc transporter ZIP12. Here we report that ZIP12 expression is increased in many cell types, including endothelial, smooth muscle and interstitial cells, in the remodelled pulmonary arterioles of rats, cows and humans susceptible to hypoxia-induced pulmonary hypertension. We show that ZIP12 expression in pulmonary vascular smooth muscle cells is hypoxia dependent and that targeted inhibition of ZIP12 inhibits the rise in intracellular labile zinc in hypoxia-exposed pulmonary vascular smooth muscle cells and their proliferation in culture. We demonstrate that genetic disruption of ZIP12 expression attenuates the development of pulmonary hypertension in rats housed in a hypoxic atmosphere. This new and unexpected insight into the fundamental role of a zinc transporter in mammalian pulmonary vascular homeostasis suggests a new drug target for the pharmacological management of pulmonary hypertension.

  6. Magnetic type transportation system

    International Nuclear Information System (INIS)

    Kobama, Masao.

    1981-01-01

    Purpose: To enable automatic transportation of nuclear substances with optional setting for the transportation distance, even for a long distance, facilitating the automation of the transportation and decreasing the space for the installation of a direction converging section of the transporting path. Constitution: A transporting vehicle having a pair of permanent magnets or ferromagnetic bodies mounted with a predetermined gap to each other along the transporting direction is provided in the transporting path including a bent direction change section for transporting specimens such as nuclear materials, and a plurality of driving vehicles having permanent magnets or ferromagnetic bodies for magnetically attracting the transporting vehicle from outside of the transporting path are arranged to the outside of the transporting path. At least one of the driving vehicles is made to run along the transporting direction of the transporting path by a driving mechanism incorporating running section such as an endless chain to drive the transportation vehicle, and the transporting vehicle is successively driven by each of the driving mechanisms. (Kawakami, Y.)

  7. The beam transport system

    International Nuclear Information System (INIS)

    1986-01-01

    The first proton beams have been transported along the transfer beamline and the diagnostic components have thus been used and tested under real operating conditions. The various electronic systems have been linked to the control system and the equipment can now be operated from the control console. The performance of the diagnostic system for the transfer beamline is satisfactory. The beam diagnostic components for the high-energy beamlines up to the isotope production and neutron therapy vaults and the first experimental target rooms have been installed. The high-energy slits have been delivered. The scanner and harp electronics have been installed and linked to their respective components in the beamlines. The pneumatic acuator control electronics has been manufactured, installed and is operational; provision has been made for special control features of the equipment in the therapy beamline. The high-voltage bias supply for the Faraday cups has been implemented. The installation of the beam current measurement system is nearing completion although part of it is already operational. A coaxial relay multiplexer for the capacitive phase probe signals has been manufactured and installed. The diagnostic equipment for the beamlines to isotope production and neutron therapy is thus ready for operation. 4 figs

  8. Vascular system associated with the sidewall of the braincase and ...

    African Journals Online (AJOL)

    1991-01-29

    Jan 29, 1991 ... The terminology of the cranial vascular system of cynodonts and early mammals is confusing and this- confusion extends to certain associated features of the bones of the braincase. In the present paper it is attempted to clear up some of this confusion and to demonstrate that previous authors have ...

  9. The skeletal vascular system - Breathing life into bone tissue.

    Science.gov (United States)

    Stegen, Steve; Carmeliet, Geert

    2017-08-26

    During bone development, homeostasis and repair, a dense vascular system provides oxygen and nutrients to highly anabolic skeletal cells. Characteristic for the vascular system in bone is the serial organization of two capillary systems, each typified by specific morphological and physiological features. Especially the arterial capillaries mediate the growth of the bone vascular system, serve as a niche for skeletal and hematopoietic progenitors and couple angiogenesis to osteogenesis. Endothelial cells and osteoprogenitor cells interact not only physically, but also communicate to each other by secretion of growth factors. A vital angiogenic growth factor is vascular endothelial growth factor and its expression in skeletal cells is controlled by osteogenic transcription factors and hypoxia signaling, whereas the secretion of angiocrine factors by endothelial cells is regulated by Notch signaling, blood flow and possibly hypoxia. Bone loss and impaired fracture repair are often associated with reduced and disorganized blood vessel network and therapeutic targeting of the angiogenic response may contribute to enhanced bone regeneration. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. VASCULAR PLANTS AS ENGINEERS OF OXYGEN IN AQUATIC SYSTEMS

    Science.gov (United States)

    The impact of organisms on oxygen is one of the most dramatic examples of ecosystem engineering on Earth. In aquatic systems, which have much lower oxygen concentrations than the atmosphere, vascular aquatic plants can affect oxygen concentrations significantly not only on long t...

  11. The plant vascular system: Evolution, development and functions

    Science.gov (United States)

    William J. Lucas; Andrew Groover; Raffael Lichtenberger; Kaori Furuta; Shri-Ram Yadav; Yka Helariutta; Xin-Qiang He; Hiroo Fukuda; Julie Kang; Siobhan M. Brady; John W. Patrick; John Sperry; Akiko Yoshida; Ana-Flor Lopez-Millan; Michael A. Grusak; Pradeep Kachroo

    2013-01-01

    The emergence of the tracheophyte-based vascular system of land plants had major impacts on the evolution of terrestrial biology, in general, through its role in facilitating the development of plants with increased stature, photosynthetic output, and ability to colonize a greatly expanded range of environmental habitats. Recently, considerable progress has been made...

  12. Transportation System Concept of Operations

    Energy Technology Data Exchange (ETDEWEB)

    N. Slater-Thompson

    2006-08-16

    The Nuclear Waste Policy Act of 1982 (NWPA), as amended, authorized the DOE to develop and manage a Federal system for the disposal of SNF and HLW. OCRWM was created to manage acceptance and disposal of SNF and HLW in a manner that protects public health, safety, and the environment; enhances national and energy security; and merits public confidence. This responsibility includes managing the transportation of SNF and HLW from origin sites to the Repository for disposal. The Transportation System Concept of Operations is the core high-level OCRWM document written to describe the Transportation System integrated design and present the vision, mission, and goals for Transportation System operations. By defining the functions, processes, and critical interfaces of this system early in the system development phase, programmatic risks are minimized, system costs are contained, and system operations are better managed, safer, and more secure. This document also facilitates discussions and understanding among parties responsible for the design, development, and operation of the Transportation System. Such understanding is important for the timely development of system requirements and identification of system interfaces. Information provided in the Transportation System Concept of Operations includes: the functions and key components of the Transportation System; system component interactions; flows of information within the system; the general operating sequences; and the internal and external factors affecting transportation operations. The Transportation System Concept of Operations reflects OCRWM's overall waste management system policies and mission objectives, and as such provides a description of the preferred state of system operation. The description of general Transportation System operating functions in the Transportation System Concept of Operations is the first step in the OCRWM systems engineering process, establishing the starting point for the lower

  13. Guidance of vascular development: lessons from the nervous system.

    Science.gov (United States)

    Larrivée, Bruno; Freitas, Catarina; Suchting, Steven; Brunet, Isabelle; Eichmann, Anne

    2009-02-27

    The vascular system of vertebrates consists of an organized, branched network of arteries, veins, and capillaries that penetrates all the tissues of the body. One of the most striking features of the vascular system is that its branching pattern is highly stereotyped, with major and secondary branches forming at specific sites and developing highly conserved organ-specific vascular patterns. The factors controlling vascular patterning are not yet completely understood. Recent studies have highlighted the anatomic and structural similarities between blood vessels and nerves. The 2 networks are often aligned, with nerve fibers and blood vessels following parallel routes. Furthermore, both systems require precise control over their guidance and growth. Several molecules with attractive and repulsive properties have been found to modulate the proper guidance of both nerves and blood vessels. These include the Semaphorins, the Slits, and the Netrins and their receptors. In this review, we describe the molecular mechanisms by which blood vessels and axons achieve proper path finding and the molecular cues that are involved in their guidance.

  14. Canadian pipeline transportation system : transportation assessment

    International Nuclear Information System (INIS)

    2009-07-01

    In addition to regulating the construction and operation of 70,000 km of oil and natural gas pipelines in Canada, the National Energy Board (NEB) regulates the trade of natural gas, oil and natural gas liquids. This report provided an assessment of the Canadian hydrocarbon transportation system in relation to its ability to provide a robust energy infrastructure. Data was collected from NEB-regulated pipeline companies and a range of publicly available sources to determine if adequate pipeline capacity is in place to transport products to consumers. The NEB also used throughput and capacity information received from pipeline operators as well as members of the investment community. The study examined price differentials compared with firm service tolls for transportation paths, as well as capacity utilization on pipelines and the degree of apportionment on major oil pipelines. This review indicated that in general, the Canadian pipeline transportation system continues to work effectively, with adequate pipeline capacity in place to move products to consumers who need them. 9 tabs., 30 figs., 3 appendices.

  15. Silicon in vascular plants: uptake, transport and its influence on mineral stress under acidic conditions.

    Science.gov (United States)

    Pontigo, Sofía; Ribera, Alejandra; Gianfreda, Liliana; de la Luz Mora, María; Nikolic, Miroslav; Cartes, Paula

    2015-07-01

    So far, considerable advances have been achieved in understanding the mechanisms of Si uptake and transport in vascular plants. This review presents a comprehensive update about this issue, but also provides the new insights into the role of Si against mineral stresses that occur in acid soils. Such information could be helpful to understand both the differential Si uptake ability as well as the benefits of this mineral element on plants grown under acidic conditions. Silicon (Si) has been widely recognized as a beneficial element for many plant species, especially under stress conditions. In the last few years, great efforts have been made to elucidate the mechanisms involved in uptake and transport of Si by vascular plants and recently, different Si transporters have been identified. Several researches indicate that Si can alleviate various mineral stresses in plants growing under acidic conditions, including aluminium (Al) and manganese (Mn) toxicities as well as phosphorus (P) deficiency all of which are highly detrimental to crop production. This review presents recent findings concerning the influence of uptake and transport of Si on mineral stress under acidic conditions because a knowledge of this interaction provides the basis for understanding the role of Si in mitigating mineral stress in acid soils. Currently, only four Si transporters have been identified and there is little information concerning the response of Si transporters under stress conditions. More investigations are therefore needed to establish whether there is a relationship between Si transporters and the benefits of Si to plants subjected to mineral stress. Evidence presented suggests that Si supply and its subsequent accumulation in plant tissues could be exploited as a strategy to improve crop productivity on acid soils.

  16. Canadian hydrocarbon transportation system : transportation assessment

    International Nuclear Information System (INIS)

    2006-06-01

    This document provided an assessment of the Canadian hydrocarbon transportation system. In addition to regulating the construction and operation of Canada's 45,000 km of pipeline that cross international and provincial borders, Canada's National Energy Board (NEB) regulates the trade of natural gas, oil and natural gas liquids. The ability of pipelines to delivery this energy is critical to the country's economic prosperity. The pipeline system includes large-diameter, cross-country, high-pressure natural gas pipelines, low-pressure crude oil and oil products pipelines and small-diameter pipelines. In order to assess the hydrocarbon transportation system, staff at the NEB collected data from pipeline companies and a range of publicly available sources. The Board also held discussions with members of the investment community regarding capital markets and emerging issues. The assessment focused largely on evaluating whether Canadians benefit from an efficient energy infrastructure and markets. The safety and environmental integrity of the pipeline system was also evaluated. The current adequacy of pipeline capacity was assessed based on price differentials compared with firm service tolls for major transportation paths; capacity utilization on pipelines; and, the degree of apportionment on major oil pipelines. The NEB concluded that the Canadian hydrocarbon transportation system is working effectively, with an adequate capacity in place on existing natural gas pipelines, but with a tight capacity on oil pipelines. It was noted that shippers continue to indicate that they are reasonably satisfied with the services provided by pipeline companies and that the NEB-regulated pipeline companies are financially stable. 14 refs, 11 tabs., 28 figs., 4 appendices

  17. 45Ca distribution and transport in saponin skinned vascular smooth muscle

    International Nuclear Information System (INIS)

    Stout, M.A.; Diecke, F.P.

    1983-01-01

    45 Ca distribution and transport were studied in chemically skinned strips of caudal artery from Kyoto Wistar rats. Sarcolemmal membranes were made hyperpermeable by exposure for 60 min to solutions containing 0.1 mg/ml of saponin. Skinned helical strips responded with graded contractions to changes in ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid buffered free Ca solutions (10(-7) to 10(-5) M) and were sensitive to the Mg-ATP concentration. Tissues loaded in the presence of 10(-7) M Ca contracted in response to 10 mM caffeine. These experiments indicate the strips are skinned and possess a functional regulatory and contractile system and an intact Ca sequestering system. 45 Ca distributes in three compartments in skinned caudal artery strips. The Ca contents of two components are linear functions of the Ca-ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid concentration and desaturate at rapid rates. They correspond to the extracellular and cytoplasmic spaces. A significantly smaller component releases Ca at comparatively slower rates. 45 Ca uptake by the slow component consists of an ATP-dependent and an ATP-independent fraction. The 45 Ca content of the ATP-dependent fraction is a function of the free Ca concentration and is independent of the Ca-ethylene glycol bis-(beta-aminoethyl ether)-N,N'-tetraacetic acid concentration. Its content was enhanced by oxalate and was abolished by Triton X-100 skinning solutions. The ATP-independent component was not affected by Triton X-100 skinning and may represent Ca binding to cytoplasmic molecules and structures. The sequestered Ca was released with caffeine or Ca but not by epinephrine. The observations indicate that the sarcoplasmic reticulum and mitochondria of vascular smooth muscle strips skinned with saponin retain their functional integrity after saponin skinning

  18. Vascular Hyperpermeability Response in Animals Systemically Exposed to Arsenic.

    Science.gov (United States)

    Chen, Shih-Chieh; Chang, Chao-Yuah; Lin, Ming-Lu

    2018-01-01

    The mechanisms underlying cardiovascular diseases induced by chronic exposure to arsenic remain unclarified. The objectives of this study were to investigate whether increased vascular leakage is induced by inflammatory mustard oil in mice systemically exposed to various doses of arsenic and whether an increased vascular leakage response is still present in arsenic-fed mice after arsenic discontinuation for 2 or 6 months. ICR mice were fed water or various doses of sodium arsenite (10, 15, or 20 mg/kg/day; 5 days/week) for 8 weeks. In separate experiments, the mice were treated with sodium arsenite (20 mg/kg) for 2 or 8 weeks, followed by arsenic discontinuation for 2 or 6 months. Vascular permeability to inflammatory mustard oil was quantified using Evans blue (EB) techniques. Both arsenic-exposed and water-fed (control) mice displayed similar basal levels of EB leakage in the ears brushed with mineral oil, a vehicle of mustard oil. The levels of EB leakage induced by mustard oil in the arsenic groups fed with sodium arsenite (10 or 15 mg/kg) were similar to those of water-fed mice. However, increased levels of EB leakage in response to mustard oil stimulation were significantly higher in mice treated with sodium arsenite (20 mg/kg; high dose) than in arsenic-fed (10 or 15 mg/kg; low and middle doses) or control mice. After arsenic discontinuation for 2 or 6 months, mustard oil-induced vascular EB leakage in arsenic-fed (20 mg/kg) mice was similar to that in control mice. Dramatic increases in mustard oil-induced vascular leakage were only present in mice systemically exposed to the high arsenic dose, indicating the synergistic effects of the high arsenic dose and mustard oil.

  19. Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth

    Energy Technology Data Exchange (ETDEWEB)

    Ashino, T.; Varadarajan, S.; Urao, N.; Oshikawa, J.; Chen, G. -F.; Wang, H.; Huo, Y.; Finney, L.; Vogt, S.; McKinney, R. D.; Maryon, E. B.; Kaplan, J. H.; Ushio-Fukai, M.; Fukai, T. (Biosciences Division); ( XSD); ( PSC-USR); (Univ. of Illinois at Chicago); (Univ. of Minnesota)

    2010-09-09

    Copper, an essential nutrient, has been implicated in vascular remodeling and atherosclerosis with unknown mechanism. Bioavailability of intracellular copper is regulated not only by the copper importer CTR1 (copper transporter 1) but also by the copper exporter ATP7A (Menkes ATPase), whose function is achieved through copper-dependent translocation from trans-Golgi network (TGN). Platelet-derived growth factor (PDGF) promotes vascular smooth muscle cell (VSMC) migration, a key component of neointimal formation. To determine the role of copper transporter ATP7A in PDGF-induced VSMC migration. Depletion of ATP7A inhibited VSMC migration in response to PDGF or wound scratch in a CTR1/copper-dependent manner. PDGF stimulation promoted ATP7A translocation from the TGN to lipid rafts, which localized at the leading edge, where it colocalized with PDGF receptor and Rac1, in migrating VSMCs. Mechanistically, ATP7A small interfering RNA or CTR small interfering RNA prevented PDGF-induced Rac1 translocation to the leading edge, thereby inhibiting lamellipodia formation. In addition, ATP7A depletion prevented a PDGF-induced decrease in copper level and secretory copper enzyme precursor prolysyl oxidase (Pro-LOX) in lipid raft fraction, as well as PDGF-induced increase in LOX activity. In vivo, ATP7A expression was markedly increased and copper accumulation was observed by synchrotron-based x-ray fluorescence microscopy at neointimal VSMCs in wire injury model. These findings suggest that ATP7A plays an important role in copper-dependent PDGF-stimulated VSMC migration via recruiting Rac1 to lipid rafts at the leading edge, as well as regulating LOX activity. This may contribute to neointimal formation after vascular injury. Our findings provide insight into ATP7A as a novel therapeutic target for vascular remodeling and atherosclerosis.

  20. Regulation and Roles of Urocortins in the Vascular System

    Directory of Open Access Journals (Sweden)

    Kazunori Kageyama

    2012-01-01

    Full Text Available Urocortins (Ucns are members of the corticotropin-releasing factor (CRF family of peptides. Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF2 receptor. Regulation and roles of each Ucn have been determined in the vascular system. Ucns have more potent vasodilatory effects than CRF. Human umbilical vein endothelial cells (HUVECs express Ucns1-3 mRNAs, and the receptor, CRF2a receptor mRNA. Ucns1-3 mRNA levels are differentially regulated in HUVECs. Differential regulation of Ucns may suggest differential roles of those in HUVECs. Ucn1 and Ucn2 have strong effects on interleukin (IL-6 gene expression and secretion in rat aortic smooth muscle A7r5 cells. The increase that we observed in IL-6 levels following Ucn treatment of A7r5 cells suggests that smooth muscle cells may be a source of IL-6 secretion under physiological stress conditions. Ucns are important and unique modulators of vascular smooth muscle cells and act directly or indirectly as autocrine and paracrine factors in the vascular system.

  1. Advanced public transportation systems benefits

    Science.gov (United States)

    1996-03-01

    Benefits and cost savings for various Advanced Public Transportation Systems are outlined here. Operational efficiencies are given for Transit Management Systems in different locales, as well as compliant resolution and safety. Electronic Fare Paymen...

  2. Intelligent Transportation Systems : critical standards

    Science.gov (United States)

    1999-06-01

    Intelligent Transportation Systems (ITS) standards are industry-consensus standards that provide the details about how different systems interconnect and communicate information to deliver the ITS user services described in the National ITS Architect...

  3. Air transport system

    CERN Document Server

    Schmitt, Dieter

    2016-01-01

    The book addresses all major aspects to be considered for the design and operation of aircrafts within the entire transportation chain. It provides the basic information about the legal environment, which defines the basic requirements for aircraft design and aircraft operation. The interactions between  airport, air traffic management and the airlines are described. The market forecast methods and the aircraft development process are explained to understand the very complex and risky business of an aircraft manufacturer. The principles of flight physics as basis for aircraft design are presented and linked to the operational and legal aspects of air transport including all environmental impacts. The book is written for graduate students as well as for engineers and experts, who are working in aerospace industry, at airports or in the domain of transport and logistics.

  4. Thermal transport in fractal systems

    DEFF Research Database (Denmark)

    Kjems, Jørgen

    1992-01-01

    Recent experiments on the thermal transport in systems with partial fractal geometry, silica aerogels, are reviewed. The individual contributions from phonons, fractons and particle modes, respectively, have been identified and can be described by quantitative models consistent with heat capacity...

  5. Self-Organized Transport System

    Science.gov (United States)

    2009-09-28

    This report presents the findings of the simulation model for a self-organized transport system where traffic lights communicate with neighboring traffic lights and make decisions locally to adapt to traffic conditions in real time. The model is insp...

  6. Inactive trials of transport systems

    International Nuclear Information System (INIS)

    Haberlin, M.M.; Hardy, A.R.

    1985-06-01

    The design and manufacture of a mock-up of a crate handling and size reduction (CHSR) facility, an experimental programme on the evaluation of a commercial air-transporter, and the selection, manufacture and commissioning trials of an integrated conveyor system for transporting crated waste into and within the mock-up facility, are considered. The mock-up facility was used for the test programme on the air-transporter and conveyor system. The air-transporter was considered suitable for transporting waste on the metal floor in the main dismantling area of the CHSR facility because it can tolerate asymmetric loading, the exhaust air flow liberated from the air-pads is low and it has excellent manoeuvrability. Commissioning trials were carried out on a commercial conveyor system consisting of unpowered rollers in the reception area, a powered slatted conveyor in the air-lock and an unpowered roller table placed on the air-transporter in the working area. It was demonstrated that a large asymmetrically loaded wooden crate can be transported into and within the facility by this method. Further design and experimental work necessary before the system can be used for remote operation is discussed. (author)

  7. ANALYISIS OF TRANSPORTATION SYSTEMS AND TRANSPORTATION POLICIES IN TURKEY

    Directory of Open Access Journals (Sweden)

    Ali Payıdar AKGÜNGÖR

    2004-03-01

    Full Text Available Transportation systems have to be considered and analysed as a whole while transportation demand, becoming as a natural outcome of socioeconomic and socio-cultural structure, is being evaluated. It is desired that transportation system, which will be selected for both passenger and freight transport, should be rapid, economic, safe, causing least harm to environment and appropriate for the conditions of a country. However, it is difficult for a transportation system to have all these properties. Every transportation system has advantages and disadvantages over each other. Therefore, comprehensive plans for future periods have to be prepared and how the sources of the country should be reasonably distributed among transportation systems must be investigated. Also, transportation plans have to be prepared to get coordinated operations among transportation systems while great investments are instituted in the entire country. There is no doubt that it is possible with combined transportation instead of concentration on one transportation system. Transportation policies in Turkey should be questioned since the level of highway transportation usage reaches to 95 % and level of sea transportation usage drops to less than 1 % in spite of being surrounded with sea in three sides of our land. In this paper, transportation systems and transportation policies in Turkey are evaluated in general and problems are analysed. Proposals are presented for the solutions of these problems.

  8. ANALYISIS OF TRANSPORTATION SYSTEMS AND TRANSPORTATION POLICIES IN TURKEY

    OpenAIRE

    Ali Payıdar AKGÜNGÖR; Abdulmuttalip DEMİREL

    2004-01-01

    Transportation systems have to be considered and analysed as a whole while transportation demand, becoming as a natural outcome of socioeconomic and socio-cultural structure, is being evaluated. It is desired that transportation system, which will be selected for both passenger and freight transport, should be rapid, economic, safe, causing least harm to environment and appropriate for the conditions of a country. However, it is difficult for a transportation system to have all these properti...

  9. Advanced Transport Operating Systems Program

    Science.gov (United States)

    White, John J.

    1990-01-01

    NASA-Langley's Advanced Transport Operating Systems Program employs a heavily instrumented, B 737-100 as its Transport Systems Research Vehicle (TRSV). The TRSV has been used during the demonstration trials of the Time Reference Scanning Beam Microwave Landing System (TRSB MLS), the '4D flight-management' concept, ATC data links, and airborne windshear sensors. The credibility obtainable from successful flight test experiments is often a critical factor in the granting of substantial commitments for commercial implementation by the FAA and industry. In the case of the TRSB MLS, flight test demonstrations were decisive to its selection as the standard landing system by the ICAO.

  10. The transport system approval concept

    International Nuclear Information System (INIS)

    Pettersson, B.G.

    1991-01-01

    The needs for, and merits of, a new concept for the safety assessment and approval of shipments of radioactive materials is introduced and discussed. The purpose of the new concept is to enable and encourage integration of analysis and review of transport safety with similar safety analysis and review of the handling operations involving the radioactive material at the despatching and receiving ends of a shipment. Safety contributing elements or functions of the means of transport (the Transport System) can thus readily be taken into account in the assessment. The objective is to avoid constraints -experienced or potential - introduced by the package functional provisions contained in the transport regulations, whilst maintaining safety during transport, as well as during facility handling operations, at least at the level at the level currently established. (author)

  11. Bevalac beam transport system

    International Nuclear Information System (INIS)

    Avery, R.; Behrsing, G.; Morgado, R.; Rondeau, D.; Salsig, W.; Selph, F.; Staples, J.; Yourd, R.

    1975-03-01

    The Bevalac consists of, in part, a 200 meter long transfer line between the SuperHILAC and the Bevatron, which are at differing elevation. Unique features in the construction of the transfer line are described. The line, located largely outside, must cope with a natural environment. Part of the line passes through a hillside, requiring some unique support and alignment techniques. The dipoles are of the tape-wound variety and the steering magnets use printed circuit conductors. The vacuum system and an inexpensive and effective destructive monitoring system are described. (U.S.)

  12. Transport phenomena in particulate systems

    CERN Document Server

    Freire, José Teixeira; Ferreira, Maria do Carmo

    2012-01-01

    This volume spans 10 chapters covering different aspects of transport phenomena including fixed and fluidized systems, spouted beds, electrochemical and wastewater treatment reactors. This e-book will be valuable for students, engineers and researchers aiming to keep updated on the latest developments on particulate systems.

  13. NUHOMS transportation system interfaces

    International Nuclear Information System (INIS)

    McConaghy, W.J.; Lehnert, R.A.; Rasmussen, R.W.

    1989-01-01

    The NUHOMS system utilizes a reinforced concrete Horizontal Storage Module (HSM) to store spent nuclear fuel assemblies which are sealed in a Dry Shielded Canister (DSC). The DSC has an internal basket assembly designed to hold 24 PWR or 60 BWR spent fuel assemblies. The HSMs are constructed in interconnected arrays on the utilities reactor site with each HSM holding one DSC. The HSMs and DSCs are the principal components of the Independent Spent Fuel Storage Installation (ISFSI) for which plants are granted a 10CFR72 (1) license by the US Nuclear Regulatory Commission (NRC) for interim dry storage. A complete description of the NUHOMS system for dry storage of spent fuel and its operation is contained in the NRC approved NUHOMS Topical Report and related publications (2, 3, 4, 6)

  14. Intelligent Transport Systems in the Management of Road Transportation

    Science.gov (United States)

    Kalupová, Blanka; Hlavoň, Ivan

    2016-11-01

    Extension of European Union causes increase of free transfer of people and goods. At the same time they raised the problems associated with the transport, e.g. congestion and related accidents on roads, air traffic delays and more. To increase the efficiency and safety of transport, the European Commission supports the introduction of intelligent transport systems and services in all transport sectors. Implementation of intelligent transport systems and services in the road transport reduces accident frequency, increases the capacity of existing infrastructure and reduces congestions. Use of toll systems provides resources needed for the construction and operation of a new road network, improves public transport, cycling transport and walking transport, and also their multimodal integration with individual car transport.

  15. Surveillance systems for intermodal transportation

    Science.gov (United States)

    Jakovlev, Sergej; Voznak, Miroslav; Andziulis, Arunas

    2015-05-01

    Intermodal container monitoring is considered a major security issue in many major logistic companies and countries worldwide. Current representation of the problem, we face today, originated in 2002, right after the 9/11 attacks. Then, a new worldwide Container Security Initiative (CSI, 2002) was considered that shaped the perception of the transportation operations. Now more than 80 larger ports all over the world contribute to its further development and integration into everyday transportation operations and improve the regulations for the developing regions. Although, these new improvements allow us to feel safer and secure, constant management of transportation operations has become a very difficult problem for conventional data analysis methods and information systems. The paper deals with a proposal of a whole new concept for the improvement of the Containers Security Initiative (CSI) by virtually connecting safety, security processes and systems. A conceptual middleware approach with deployable intelligent agent modules is proposed to be used with possible scenarios and a testbed is used to test the solution. Middleware examples are visually programmed using National Instruments LabView software packages and Wireless sensor network hardware modules. An experimental software is used to evaluate he solution. This research is a contribution to the intermodal transportation and is intended to be used as a means or the development of intelligent transport systems.

  16. Genetic fuzzy system modeling and simulation of vascular behaviour

    DEFF Research Database (Denmark)

    Tang, Jiaowei; Boonen, Harrie C.M.

    Background: The purpose of our project is to identify the rule sets and their interaction within the framework of cardiovascular function. By an iterative process of computational simulation and experimental work, we strive to mimic the physiological basis for cardiovascular adaptive changes in c...... the pressure change of different blood vessels. Conclusion: Genetic fuzzy system is one of potential modeling methods in modeling and simulation of vascular behavior.......Background: The purpose of our project is to identify the rule sets and their interaction within the framework of cardiovascular function. By an iterative process of computational simulation and experimental work, we strive to mimic the physiological basis for cardiovascular adaptive changes...... in cardiovascular disease and ultimately improve pharmacotherapy. For this purpose, novel computational approaches incorporating adaptive properties, auto-regulatory control and rule sets will be assessed, properties that are commonly lacking in deterministic models based on differential equations. We hypothesize...

  17. NASAs VESGEN: Systems Analysis of Vascular Phenotypes from Stress and Other Signaling Pathways Using GeneLab.

    Science.gov (United States)

    Parsons-Wingerter, Patricia A.; Weitzel, Alexander; Vyas, Ruchi J.; Murray, Matthew C.; Wyatt, Sarah E.

    2016-01-01

    One fundamental requirement shared by humans with all higher terrestrial life forms, including insect wings, higher land plants and other vertebrates, is a complex, fractally branching vascular system. NASA's VESsel GENeration Analysis (VESGEN) software maps and quantifies vascular trees, networks, and tree-network composites according to weighted physiological rules such as vessel connectivity, tapering and bifurcational branching. According to fluid dynamics, successful vascular transport requires a complex distributed system of highly regulated laminar flow. Microvascular branching rules within vertebrates, dicot leaves and the other organisms therefore display many similarities. One unifying perspective is that vascular patterning offers a useful readout that necessarily integrates complex molecular signaling pathways. VESGEN has elucidated changes in vascular pattern resulting from inflammatory, stress response, developmental and other signaling within numerous tissues and major model organisms studied for Space Biology. For a new VESGEN systems approach, we analyzed differential gene expression in leaves of Arabidopsis thaliana reported by GeneLab (GLDS-7) for spaceflight. Vascular-related changes in leaf gene expression were identified that can potentially be phenocopied by mutants in ground-based experiments. To link transcriptional, protein and other molecular change with phenotype, alterations in the Euclidean and dynamic dimensions (x,y,t) of vascular patterns for Arabidopsis leaves and other model species are being co-localized with signaling patterns of single molecular expression analyzed as information dimensions (i,j,k,...). Previously, Drosophila microarray data returned from space suggested significant changes in genes related to wing venation development that include EGF, Notch, Hedghog, Wingless and Dpp signaling. Phenotypes of increasingly abnormal ectopic wing venation in the (non-spaceflight) Drosophila wing generated by overexpression of a

  18. Quantum transport in complex system

    International Nuclear Information System (INIS)

    Kusnezov, D.; Bulgac, A.; DoDang, G.

    1998-01-01

    We derive the influence function and the effective dynamics of a quantum systems coupled to a chaotic environment, using very general parametric and banded random matrices to describe the quantum properties of a chaotic bath. We find that only in certain limits the thermalization can result from the environment. We study the general transport problems including escape, fusion and tunneling (fission). (author)

  19. Stroke from systemic vascular disorders in Saudi children: The devastating role of hypernatremic dehydration

    International Nuclear Information System (INIS)

    Salih, Mustafa A.; Al-Jarallah, Ahmed A.; Zahraa, Jihad N.; Alorainy, Ibrahim A.; Hassan, Hamdy H.

    2006-01-01

    Systemic vascular disorders, leading to childhood stroke, include volume depletion or systemic hypotension and hypernatremic dehydration. We describe 3 cases of stroke following systemic vascular disorders. These were diagnosed during a prospective and retrospective study on childhood stroke, which included 104 patients. Post-gastroenteritis hypernatremic dehydration is an important, potentially preventable, cause of stroke in Saudi children. (author)

  20. Neoclassical transport in toroidal systems

    International Nuclear Information System (INIS)

    Wobig, H.

    1992-01-01

    The neoclassical theory of general toroidal equilibria is reformulated. The toroidal equilibrium of tokamaks and stellarators are described in Hamada coordinates. The relevant geometrical parameters are identified and it is shown how the reduction of Pfirsch-Schluter currents affects neoclassical transport and bootstrap effects. General flux-friction relations between thermodynamic forces and fluxes are derived. In drift-kinetic approximation the neoclassical transport coefficients are Onsager symmetric. Since a toroidal loop voltage is included, the theory is valid for all toroidal systems. (Author)

  1. Integrated Intermodal Passenger Transportation System

    Science.gov (United States)

    Klock, Ryan; Owens, David; Schwartz, Henry; Plencner, Robert

    2012-01-01

    Modern transportation consists of many unique modes of travel. Each of these modes and their respective industries has evolved independently over time, forming a largely incoherent and inefficient overall transportation system. Travelers today are forced to spend unnecessary time and efforts planning a trip through varying modes of travel each with their own scheduling, pricing, and services; causing many travelers to simply rely on their relatively inefficient and expensive personal automobile. This paper presents a demonstration program system to not only collect and format many different sources of trip planning information, but also combine these independent modes of travel in order to form optimal routes and itineraries of travel. The results of this system show a mean decrease in inter-city travel time of 10 percent and a 25 percent reduction in carbon dioxide emissions over personal automobiles. Additionally, a 55 percent reduction in carbon dioxide emissions is observed for intra-city travel. A conclusion is that current resources are available, if somewhat hidden, to drastically improve point to point transportation in terms of time spent traveling, the cost of travel, and the ecological impact of a trip. Finally, future concepts are considered which could dramatically improve the interoperability and efficiency of the transportation infrastructure.

  2. System Convergence in Transport Modelling

    DEFF Research Database (Denmark)

    Rich, Jeppe; Nielsen, Otto Anker; Cantarella, Guilio E.

    2010-01-01

    A fundamental premise of most applied transport models is the existence and uniqueness of an equilibrium solution that balances demand x(t) and supply t(x). The demand consists of the people that travel in the transport system and on the defined network, whereas the supply consists of the resulting...... level-of-service attributes (e.g., travel time and cost) offered to travellers. An important source of complexity is the congestion, which causes increasing demand to affect travel time in a non-linear way. Transport models most often involve separate models for traffic assignment and demand modelling...... iterating between a route-choice (demand) model and a time-flow (supply) model. It is generally recognised that a simple iteration scheme where the level-of-service level is fed directly to the route-choice and vice versa may exhibit an unstable pattern and lead to cyclic unstable solutions. It can be shown...

  3. A semi-automated vascular access system for preclinical models

    International Nuclear Information System (INIS)

    Berry-Pusey, B N; David, J; Taschereau, R; Silverman, R W; Williams, D; Ladno, W; Stout, D; Chatziioannou, A; Chang, Y C; Prince, S W; Chu, K; Tsao, T C

    2013-01-01

    Murine models are used extensively in biological and translational research. For many of these studies it is necessary to access the vasculature for the injection of biologically active agents. Among the possible methods for accessing the mouse vasculature, tail vein injections are a routine but critical step for many experimental protocols. To perform successful tail vein injections, a high skill set and experience is required, leaving most scientists ill-suited to perform this task. This can lead to a high variability between injections, which can impact experimental results. To allow more scientists to perform tail vein injections and to decrease the variability between injections, a vascular access system (VAS) that semi-automatically inserts a needle into the tail vein of a mouse was developed. The VAS uses near infrared light, image processing techniques, computer controlled motors, and a pressure feedback system to insert the needle and to validate its proper placement within the vein. The VAS was tested by injecting a commonly used radiolabeled probe (FDG) into the tail veins of five mice. These mice were then imaged using micro-positron emission tomography to measure the percentage of the injected probe remaining in the tail. These studies showed that, on average, the VAS leaves 3.4% of the injected probe in the tail. With these preliminary results, the VAS system demonstrates the potential for improving the accuracy of tail vein injections in mice. (paper)

  4. Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation

    Directory of Open Access Journals (Sweden)

    Nemmar A

    2014-06-01

    Full Text Available Abderrahim Nemmar,1 Sulayma Albarwani,2 Sumaya Beegam,1 Priya Yuvaraju,1 Javed Yasin,3 Samir Attoub,4 Badreldin H Ali5 1Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 2Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Sultanate of Oman; 3Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 4Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 5Department of Pharmacology, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Sultanate of Oman Abstract: Amorphous silica nanoparticles (SiNPs are being used in biomedical, pharmaceutical, and many other industrial applications entailing human exposure. However, their potential vascular and systemic pathophysiologic effects are not fully understood. Here, we investigated the acute (24 hours systemic toxicity of intraperitoneally administered 50 nm and 500 nm SiNPs in mice (0.5 mg/kg. Both sizes of SiNPs induced a platelet proaggregatory effect in pial venules and increased plasma concentration of plasminogen activator inhibitor-1. Elevated plasma levels of von Willebrand factor and fibrinogen and a decrease in the number of circulating platelets were only seen following the administration of 50 nm SiNPs. The direct addition of SiNPs to untreated mouse blood significantly induced in vitro platelet aggregation in a dose-dependent fashion, and these effects were more pronounced with 50 nm SiNPs. Both sizes of SiNPs increased lactate dehydrogenase activity and interleukin 1β concentration. However, tumor necrosis factor α concentration was only increased after the administration of 50 nm SiNPs. Nevertheless, plasma markers of oxidative stress, including 8-isoprostane

  5. ESKIMO1 disruption in Arabidopsis alters vascular tissue and impairs water transport.

    Directory of Open Access Journals (Sweden)

    Valérie Lefebvre

    Full Text Available Water economy in agricultural practices is an issue that is being addressed through studies aimed at understanding both plant water-use efficiency (WUE, i.e. biomass produced per water consumed, and responses to water shortage. In the model species Arabidopsis thaliana, the ESKIMO1 (ESK1 gene has been described as involved in freezing, cold and salt tolerance as well as in water economy: esk1 mutants have very low evapo-transpiration rates and high water-use efficiency. In order to establish ESK1 function, detailed characterization of esk1 mutants has been carried out. The stress hormone ABA (abscisic acid was present at high levels in esk1 compared to wild type, nevertheless, the weak water loss of esk1 was independent of stomata closure through ABA biosynthesis, as combining mutant in this pathway with esk1 led to additive phenotypes. Measurement of root hydraulic conductivity suggests that the esk1 vegetative apparatus suffers water deficit due to a defect in water transport. ESK1 promoter-driven reporter gene expression was observed in xylem and fibers, the vascular tissue responsible for the transport of water and mineral nutrients from the soil to the shoots, via the roots. Moreover, in cross sections of hypocotyls, roots and stems, esk1 xylem vessels were collapsed. Finally, using Fourier-Transform Infrared (FTIR spectroscopy, severe chemical modifications of xylem cell wall composition were highlighted in the esk1 mutants. Taken together our findings show that ESK1 is necessary for the production of functional xylem vessels, through its implication in the laying down of secondary cell wall components.

  6. History of Bioelectrical Study and the Electrophysiology of the Primo Vascular System

    Directory of Open Access Journals (Sweden)

    Sang Hyun Park

    2013-01-01

    Full Text Available Background. Primo vascular system is a new anatomical structure whose research results have reported the possibility of a new circulatory system similar to the blood vascular system and cells. Electrophysiology, which measures and analyzes bioelectrical signals tissues and cells, is an important research area for investigating the function of tissues and cells. The bioelectrical study of the primo vascular system has been reported by using modern techniques since the early 1960s by Bonghan Kim. This paper reviews the research result of the electrophysiological study of the primo vascular system for the discussion of the circulatory function. We hope it would help to study the electrophysiology of the primo vascular system for researchers. This paper will use the following exchangeable expressions: Kyungrak system = Bonghan system = Bonghan circulatory system = primo vascular system = primo system; Bonghan corpuscle = primo node; Bonghan duct = primo vessel. We think that objective descriptions of reviewed papers are more important than unified expressions when citing the papers. That said, this paper will unify the expressions of the primo vascular system.

  7. Physical System Requirements: Transport Waste

    International Nuclear Information System (INIS)

    1992-04-01

    The Nuclear Waste Policy Act (NWPA) of 1982 assigned to the Department of Energy (DOE) the responsibility for managing the disposal of spent nuclear fuel and high-level radioactive waste and established the Office of Civilian Radioactive Waste Management (OCRWM) for that purpose. The Secretary of Energy, in his November 1989 report to Congress (DOE/RW-0247), announced three new initiatives for the conduct of the Civilian Radioactive Waste Management (CRWM) program. One of these initiatives was to establish improved management structure and procedures. In response, OCRWM performed a management study and the Director subsequently issued the Management Systems Improvement Strategy (MSIS) on August 10, 1990, calling for a rigorous implementation of systems engineering principles with a special emphasis on functional analysis. The functional analysis approach establishes a framework for integrating the program management efforts with the technical requirements analysis into a single, unified, and consistent program. This approach recognizes that just as the facilities and equipment comprising the physical waste management system must perform certain functions, so must certain programmatic and management functions be performed within the program in order to successfully bring the physical system into being. The objective of this document is to establish the essential functions, requirements, interfaces, and system architecture for the Transport Waste mission. Based upon the Nuclear Waste Policy Act, the mission of the Waste Transportation System is to transport SNF and/or HLW from the purchaser's/producer's facilities to, and between, NWMS facilities in a manner that protects the health and safety of the public and of workers and the quality of the environment makes effective use of financial and other resources, and to the fullest extent possible uses the private sector

  8. Using NASA's GeneLab for VESGEN Systems Analysis of Vascular Phenotypes from Stress and Other Signaling Pathways

    Science.gov (United States)

    Parsons-Wingerter, P.; Weitzel, Alexander; Vyas, R. J.; Murray, M. C.; Vickerman, M. B.; Bhattacharya, S.; Wyatt, S. E.

    2016-01-01

    One fundamental requirement shared by humans with all higher terrestrial life forms, including other vertebrates, insects, and higher land plants, is a complex, fractally branching vascular system. NASA's VESsel GENeration Analysis (VESGEN) software maps and quantifies vascular trees, networks, and tree-network composites according to weighted physiological rules such as vessel connectivity, tapering and bifurcational branching. According to fluid dynamics, successful vascular transport requires a complex distributed system of highly regulated laminar flow. Microvascular branching rules within vertebrates, dicot leaves and the other organisms therefore display many similarities. A unifying perspective is that vascular patterning offers a useful readout of molecular signaling that necessarily integrates these complex pathways. VESGEN has elucidated changes in vascular pattern resulting from inflammatory, developmental and other signaling within numerous tissues and major model organisms studied for Space Biology. For a new VESGEN systems approach, we analyzed differential gene expression in leaves of Arabidopsis thaliana reported by GeneLab (GLDS-7) for spaceflight. Vascularrelated changes in leaf gene expression were identified that can potentially be phenocopied by mutants in ground-based experiments. To link transcriptional, protein and other molecular change with phenotype, alterations in the spatial and dynamic dimensions of vascular patterns for Arabidopsis leaves and other model species are being co-localized with signaling patterns of single molecular expression analyzed as information dimensions. Previously, Drosophila microarray data returned from space suggested significant changes in genes related to wing venation development that include EGF, Notch, Hedghog, Wingless and Dpp signaling. Phenotypes of increasingly abnormal ectopic wing venation in the (non-spaceflight) Drosophila wing generated by overexpression of a Notch antagonist were analyzed by

  9. Increased systemic vascular resistance in neonates with pulmonary hypertension.

    Science.gov (United States)

    Milstein, J M; Goetzman, B W; Riemenschneider, T A; Wennberg, R P

    1979-11-01

    The time necessary for aortic diastolic pressure to decrease to 50 percent of an initially selected value after dissipation of the dicrotic notch (T 1/2) was determined in newborn infants with and without pulmonary hypertension. The mean T 1/2 was 671 +/- 167 msec in seven infants with clinical evidence of pulmonary hypertension and documented right to left ductus arteriosus shunting; 849 +/- 243 msec in nine infants with clinical evidence of pulmonary hypertension but no documented right to left ductus arteriosus shunting; and 457 +/- 66 msec in eight infants with hyaline membrane disease and no clinical evidence of pulmonary hypertension or a patent ductus arteriosus. The mean T 1/2 values in the former two groups were significantly different from that in the group with no pulmonary hypertension (P less than 0.01). An evaluation of factors affecting T 1/2 leads to the conclusion that the patients with pulmonary hypertension had increased systemic vascular resistance as well. This finding has important diagnostic, etiologic and therapeutic implications.

  10. Improved FPGA controlled artificial vascular system for plethysmographic measurements

    Directory of Open Access Journals (Sweden)

    Laqua Daniel

    2016-09-01

    Full Text Available The fetal oxygen saturation is an important parameter to determine the health status of a fetus, which is until now mostly acquired invasively. The transabdominal, fetal pulse oximetry is a promising approach to measure this non-invasively and continuously. The fetal pulse curve has to be extracted from the mixed signal of mother and fetus to determine its oxygen saturation. For this purpose efficient algorithms are necessary, which have to be evaluated under constant and reproducable test conditions. This paper presents the improved version of a phantom which can generate artificial pulse waves in a synthetic tissue phantom. The tissue phantom consists of several layers that mimic the different optical properties of the fetal and maternal tissue layers. Additionally an artificial vascular system and a dome, which mimics the bending of the belly of a pregnant woman, are incorporated. To obtain data on the pulse waves, several measurement methods are included, to help understand the behavior of the signals gained from the pulse waves. Besides pressure sensors and a transmissive method we integrated a capacitive approach, that makes use of the so called “Pin Oscillator” method. Apart from the enhancements in the tissue phantom and the measurements, we also improved the used blood substitute, which reproduces the different absorption characteristics of fetal and maternal blood. The results show that the phantom can generate pulse waves similar to the natural ones. Furthermore, the phantom represents a reference that can be used to evaluate the algorithms for transabdominal, fetal pulse oximetry.

  11. Effectiveness of work zone intelligent transportation systems.

    Science.gov (United States)

    2013-12-01

    In the last decade, Intelligent Transportation Systems (ITS) have increasingly been deployed in work zones by state departments of transportation. Also known as smart work zone systems they improve traffic operations and safety by providing real-time...

  12. The influence of the telomere-telomerase system on diabetes mellitus and its vascular complications.

    Science.gov (United States)

    Qi Nan, Wu; Ling, Zhang; Bing, Chen

    2015-06-01

    The telomere-telomerase system plays an important role in the pathogenesis and disease progression of diabetes mellitus as well as in its vascular complications. Recent studies suggest that telomere shortening and abnormal telomerase activity occur in patients with diabetes mellitus, and targeting the telomere-telomerase system has become a prospective treatment for diabetes mellitus and its vascular complications. This review highlights the significance of the telomere-telomerase system and supports its role as a possible therapeutic target for patients with diabetes mellitus and its vascular complications Areas covered: This review covers the advances in understanding the telomere-telomerase system over the last 30 years and its significance in diabetes mellitus. In addition, it provides knowledge regarding the significance of the telomere-telomerase system in diabetes mellitus and its vascular complications as well as its role and mechanisms in oxidative stress, cell therapy and antioxidant activity Expert opinion: The telomere-telomerase system may be a potential therapeutic target that can protect against DNA damage and apoptosis in patients with diabetes mellitus and its vascular complications. DNA damage and apoptosis are associated with oxidative stress and are involved in the dysfunction of pancreatic β cells, insulin resistance, and its vascular complications. Abnormalities in the telomere-telomerase system may be associated with diabetes mellitus and its vascular complications. Therapies targeting telomere-telomerase system, telomerase reverse transcriptase transfection and alterative telomere lengthening must be identified before gene therapy can commence.

  13. ADVANCES IN ZERO ENERGY TRANSPORTATION SYSTEMS

    OpenAIRE

    Ahmad, Othman

    2017-01-01

    Hyperloop mass transportation systems are activelydeveloped at the moment. They represent the forefront development of the ZeroEnergy Transportation systems where air drag is minimized by travelling in avacuum and friction is reduced by non-contact bearings. Hyperloop supportersare confident that the cost of their transportation systems would be lowcompared to existing transportation systems because of the low loss andtherefore low energy consumption as well as other cost-saving techniquesdoc...

  14. Early Detection System of Vascular Disease and Its Application Prospect

    Directory of Open Access Journals (Sweden)

    Huan Liu

    2016-01-01

    Full Text Available Markers of imaging, structure, and function reflecting vascular damage, integrating a long time accumulation effect of traditional and unrecognized cardiovascular risk factors, can be regarded as surrogate endpoints of target organ damage before the occurrence of clinical events. Prevention of cardiovascular disease requires risk stratification and treatment of traditional risk factors, such as smoking, hypertension, hyperlipidemia, and diabetes. However, traditional risk stratification is not sufficient to provide accurate assessment of future cardiovascular events. Therefore, vascular injury related parameters obtained by ultrasound or other noninvasive devices, as a surrogate parameter of subclinical cardiovascular disease, can improve cardiovascular risk assessment and optimize the preventive treatment strategy. Thus, we will summarize the research progress and clinical application of early assessment technology of vascular diseases in the present review.

  15. Effect of hypertensive rat plasma on ion transport of cultured vascular smooth muscle

    International Nuclear Information System (INIS)

    Magargal, W.W.; Overbeck, H.W.

    1986-01-01

    We layered fresh, unprocessed plasma from healthy rats with early (less than or equal to 7 days) or benign, chronic (greater than 3 wk) one-kidney, one-clip hypertension and from paired one-kidney normotensive control rats over confluent primary-cultured rat aortic smooth muscle cells. Plasma from all rats increased cellular ouabain-sensitive 86 Rb + uptake and sodium content and decreased ouabain-insensitive 86 Rb + uptake compared with uptakes and content in the presence of balanced salt solution (P less than 0.01). Cells incubated in the presence of plasma from rats with early (P less than 0.02) or chronic hypertension (P less than 0.01) had significantly reduced ouabain-sensitive 86 Rb + uptake when compared with cells incubated in normotensive plasma, but their intracellular Na+ contents were not lower. We no longer detected this uptake difference when chronic hypertensives drank 0.9% NaCl instead of water. Plasma from hypertensive rats also altered ouabain-insensitive 86 Rb + uptake by the cultured cells. These findings of this new, reproducible, and specific assay system support the hypothesis that plasma factors inhibit the membrane sodium-potassium pump in vascular smooth muscle cells in this form of hypertension. The abnormality occurs in both early and chronic stages, but may not be related to sodium intake. The data also provide evidence for plasma factors in hypertension altering membrane K+ permeability

  16. Road Transportable Analytical Laboratory system

    International Nuclear Information System (INIS)

    Finger, S.M.; Keith, V.F.; Spertzel, R.O.; De Avila, J.C.; O'Donnell, M.; Vann, R.L.

    1993-09-01

    This developmental effort clearly shows that a Road Transportable Analytical Laboratory System is a worthwhile and achievable goal. The RTAL is designed to fully analyze (radioanalytes, and organic and inorganic chemical analytes) 20 samples per day at the highest levels of quality assurance and quality control. It dramatically reduces the turnaround time for environmental sample analysis from 45 days (at a central commercial laboratory) to 1 day. At the same time each RTAL system will save the DOE over $12 million per year in sample analysis costs compared to the costs at a central commercial laboratory. If RTAL systems were used at the eight largest DOE facilities (at Hanford, Savannah River, Fernald, Oak Ridge, Idaho, Rocky Flats, Los Alamos, and the Nevada Test Site), the annual savings would be $96,589,000. The DOE's internal study of sample analysis needs projects 130,000 environmental samples requiring analysis in FY 1994, clearly supporting the need for the RTAL system. The cost and time savings achievable with the RTAL system will accelerate and improve the efficiency of cleanup and remediation operations throughout the DOE complex

  17. Urban Transportation Planning Short Course: Evaluation of Alternative Transportation Systems.

    Science.gov (United States)

    Federal Highway Administration (DOT), Washington, DC.

    This urban transportation pamphlet delves into the roles of policy groups and technical staffs in evaluating alternative transportation plans, evaluation criteria, systems to evaluate, and evaluation procedures. The introduction admits the importance of subjective, but informed, judgment as an effective tool in weighing alternative transportation…

  18. Performances of the HL (Hyperloop) transport system

    NARCIS (Netherlands)

    van Goeverden, C.D.; Milakis, D.; Janic, M.; Konings, J.W.; Cools, M.; Limbourg, S.

    2017-01-01

    This paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental.

  19. Plant Vascular Biology 2010

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Biao

    2014-11-17

    This grant supported the Second International Conference on Plant Vascular Biology (PVB 2010) held July 24-28, 2010 on the campus of Ohio State University, Columbus, Ohio. Biao Ding (Ohio State University; OSU) and David Hannapel (Iowa State University; ISU) served as co-chairs of this conference. Biao Ding served as the local organizer. PVB is defined broadly here to include studies on the biogenesis, structure and function of transport systems in plants, under conditions of normal plant growth and development as well as of plant interactions with pathogens. The transport systems cover broadly the xylem, phloem, plasmodesmata and vascular cell membranes. The PVB concept has emerged in recent years to emphasize the integrative nature of the transport systems and approaches to investigate them.

  20. Radioisotope Thermoelectric Generator Transport Trailer System

    International Nuclear Information System (INIS)

    Ard, K.E.; King, D.A.; Leigh, H.; Satoh, J.A.

    1994-01-01

    The Radioisotope Thermoelectric Generator (RTG) Transportation System, designated as System 100, comprises four major systems. The four major systems are designated as the Packaging System (System 120), Trailer System (System 140), Operations and Ancillary Equipment System system 160), and Shipping and Receiving Facility Transport System (System 180). Packaging System (System 120), including the RTG packaging is licensed (regulatory) hardware; it is certified by the US Department of Energy to be in accordance with Title 10, Code of federal Regulations, Part 71 (10 CFR 71). System 140, System 160, and System 180 are nonlicensed (nonregulatory) hardware

  1. Vascular Stiffness and Increased Pulse Pressure in the Aging Cardiovascular System

    Directory of Open Access Journals (Sweden)

    Jochen Steppan

    2011-01-01

    Full Text Available Aging leads to a multitude of changes in the cardiovascular system, including systolic hypertension, increased central vascular stiffness, and increased pulse pressure. In this paper we will review the effects of age-associated increased vascular stiffness on systolic blood pressure, pulse pressure, augmentation index, and cardiac workload. Additionally we will describe pulse wave velocity as a method to measure vascular stiffness and review the impact of increased vascular stiffness as an index of vascular health and as a predictor of adverse cardiovascular outcomes. Furthermore, we will discuss the underlying mechanisms and how these may be modified in order to change the outcomes. A thorough understanding of these concepts is of paramount importance and has therapeutic implications for the increasingly elderly population.

  2. SDDOT transportation systems management & operations program plan.

    Science.gov (United States)

    2016-06-01

    The objective of this project is the development of a comprehensive Transportation Systems Management and : Operations (TSM&O) Program Plan for the South Dakota Department of Transportation. This plan guides : business planning and strategic decision...

  3. Anomalous transport in mirror systems

    International Nuclear Information System (INIS)

    Post, R.F.

    1979-01-01

    As now being explored for fusion applications confinement systems based on the mirror principle embody two kinds of plasma regimes. These two regimes are: (a) high-beta plasmas, stabilized against MHD and other low frequency plasma instabilities by magnetic-well fields, but characterized by non-Maxwellian ion distributions; (b) near-Maxwellian plasmas, confined electrostatically (as in the tandem mirror) or in a field-reversed region within the mirror cell. Common to both situations are the questions of anomalous transport owing to high frequency instabilities in the non-maxwellian portions of the plasmas. This report will summarize the status of theory and of experimental data bearing on these questions, with particular reference to the high temperature regimes of interest for fusion power

  4. Arabidopsis thickvein mutation affects vein thickness and organ vascularization, and resides in a provascular cell-specific spermine synthase involved in vein definition and in polar auxin transport.

    Science.gov (United States)

    Clay, Nicole K; Nelson, Timothy

    2005-06-01

    Polar auxin transport has been implicated in the induction of vascular tissue and in the definition of vein positions. Leaves treated with chemical inhibitors of polar auxin transport exhibited vascular phenotypes that include increased vein thickness and vascularization. We describe a recessive mutant, thickvein (tkv), which develops thicker veins in leaves and in inflorescence stems. The increased vein thickness is attributable to an increased number of vascular cells. Mutant plants have smaller leaves and shorter inflorescence stems, and this reduction in organ size and height is accompanied by an increase in organ vascularization, which appears to be attributable to an increase in the recruitment of cells into veins. Furthermore, although floral development is normal, auxin transport in the inflorescence stem is significantly reduced in the mutant, suggesting that the defect in auxin transport is responsible for the vascular phenotypes. In the primary root, the veins appear morphologically normal, but root growth in the tkv mutant is hypersensitive to exogenous cytokinin. The tkv mutation was found to reside in the ACL5 gene, which encodes a spermine synthase and whose expression is specific to provascular cells. We propose that ACL5/TKV is involved in vein definition (defining the boundaries between veins and nonvein regions) and in polar auxin transport, and that polyamines are involved in this process.

  5. Transport barrier in Helical system

    International Nuclear Information System (INIS)

    Ida, Katsumi

    1998-01-01

    Experiments on the transport barrier in Helical plasmas are reviewed. There are two mechanisms of transport improvement, that results in the formation of the transport barrier. One is the improvement of neoclassical transport by reducing the ripple loss with radial electric field, which exist only in helical plasma. The other is the improvement of anomalous transport due to the suppression of fluctuations associated with a radial electric field shear both in tokamak and helical plasma. The formation of the transport barrier can be triggered by the radial electric field shear associated with the transition of the radial electric field (L/H transition or ion-electron root transition) or the peaked density or the optimization of magnetic field shear. The mechanisms of transport barrier formation are also discussed. (author). 60 refs

  6. Intelligent transportation systems problems and perspectives

    CERN Document Server

    Pamuła, Wiesław

    2016-01-01

    This book presents a discussion of problems encountered in the deployment of Intelligent Transport Systems (ITS). It puts emphasis on the early tasks of designing and proofing the concept of integration of technologies in Intelligent Transport Systems. In its first part the book concentrates on the design problems of urban ITS. The second part of the book features case studies representative for the different modes of transport. These are freight transport, rail transport and aerospace transport encompassing also space stations. The book provides ideas for deployment which may be developed by scientists and engineers engaged in the design of Intelligent Transport Systems. It can also be used in the training of specialists, students and post-graduate students in universities and transport high schools.    .

  7. Evaluation of intelligent transport systems impact on school transport safety

    Directory of Open Access Journals (Sweden)

    Jankowska-Karpa Dagmara

    2017-01-01

    Full Text Available The integrated system of safe transport of children to school using Intelligent Transport Systems was developed and implemented in four locations across Europe under the Safeway2School (SW2S project, funded by the EU. The SW2S system evaluation included speed measurements and an eye-tracking experiment carried out among drivers who used the school bus route, where selected elements of the system were tested. The subject of the evaluation were the following system elements: pedestrian safety system at the bus stop (Intelligent Bus Stop and tags for children, Driver Support System, applications for parents’ and students’ mobile phones, bus stop inventory tool and data server. A new sign designed for buses and bus stops to inform about child transportation/children waiting at the bus stop was added to the system. Training schemes for system users were also provided. The article presents evaluation results of the impact of selected elements of the SW2S system on school transport safety in Poland.

  8. Nonlinear transport of dynamic system phase space

    International Nuclear Information System (INIS)

    Xie Xi; Xia Jiawen

    1993-01-01

    The inverse transform of any order solution of the differential equation of general nonlinear dynamic systems is derived, realizing theoretically the nonlinear transport for the phase space of nonlinear dynamic systems. The result is applicable to general nonlinear dynamic systems, with the transport of accelerator beam phase space as a typical example

  9. Magnetic levitation -The future transport system

    International Nuclear Information System (INIS)

    Rairan, Danilo

    2000-01-01

    The paper made a recount of the main advantages and disadvantages of the traditional systems of transport with base in electric power and it shows as the systems that use the magnetic levitation they are the future of the transport. Additionally it presents the physical principle of operation of the two main systems developed at the present time

  10. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik; Nørgaard, P.

    2008-01-01

    No single technology can solve the problem of ever increasing CO2 emissions from transport. Here, a coherent effort to integrate transport into energyplanning is proposed, using multiple means promoting sustainable transport. It is concluded that a 100 per cent renewable energy transport system...... is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production of food. The integration of the transport with the energy system is crucial as is a multi-pronged strategy. Short term solutions have to consider...

  11. A National MagLev Transportation System

    Science.gov (United States)

    Wright, Michael R.

    2003-01-01

    The case for a national high-speed magnetic-levitation (MagLev) transportation system is presented. Focus is on current issues facing the country, such as national security, the economy, transportation, technology, and the environment. NASA s research into MagLev technology for launch assist is also highlighted. Further, current socio-cultural norms regarding motor-vehicle-based transportation systems are questioned in light of the problems currently facing the U.S. The multidisciplinary benefits of a long-distance MagLev system support the idea that such a system would be an important element of a truly multimodal U.S. transportation infrastructure.

  12. METHODS OF INTEGRATED OPTIMIZATION MAGLEV TRANSPORT SYSTEMS

    Directory of Open Access Journals (Sweden)

    A. Lasher

    2013-09-01

    Full Text Available Purpose. To demonstrate feasibility of the proposed integrated optimization of various MTS parameters to reduce capital investments as well as decrease any operational and maintenance expense. This will make use of MTS reasonable. At present, the Maglev Transport Systems (MTS for High-Speed Ground Transportation (HSGT almost do not apply. Significant capital investments, high operational and maintenance costs are the main reasons why Maglev Transport Systems (MTS are hardly currently used for the High-Speed Ground Transportation (HSGT. Therefore, this article justifies use of Theory of Complex Optimization of Transport (TCOT, developed by one of the co-authors, to reduce MTS costs. Methodology. According to TCOT, authors developed an abstract model of the generalized transport system (AMSTG. This model mathematically determines the optimal balance between all components of the system and thus provides the ultimate adaptation of any transport systems to the conditions of its application. To identify areas for effective use of MTS, by TCOT, the authors developed a dynamic model of distribution and expansion of spheres of effective use of transport systems (DMRRSEPTS. Based on this model, the most efficient transport system was selected for each individual track. The main estimated criterion at determination of efficiency of application of MTS is the size of the specific transportation tariff received from calculation of payback of total given expenses to a standard payback period or term of granting the credit. Findings. The completed multiple calculations of four types of MTS: TRANSRAPID, MLX01, TRANSMAG and TRANSPROGRESS demonstrated efficiency of the integrated optimization of the parameters of such systems. This research made possible expending the scope of effective usage of MTS in about 2 times. The achieved results were presented at many international conferences in Germany, Switzerland, United States, China, Ukraine, etc. Using MTS as an

  13. Computer-aided design of microvasculature systems for use in vascular scaffold production

    Energy Technology Data Exchange (ETDEWEB)

    Mondy, William Lafayette [Department of Chemical and Biomedical Engineering, University of South Florida, FL (United States); Cameron, Don [Department of Pathology and Cell Biology, College of Medicine, University of South Florida, FL (United States); Timmermans, Jean-Pierre [Department of Veterinary Sciences, University of Antwerp (Belgium); De Clerck, Nora [Department of Biomedical Sciences University of Antwerp (Belgium); Sasov, Alexander [Skyscan (Belgium); Casteleyn, Christophe [College of Veterinary Medicine, Ghent University (Belgium); Piegl, Les A [Department of Computer Science and Engineering, University of South Florida, FL (United States)

    2009-09-15

    In vitro biomedical engineering of intact, functional vascular networks, which include capillary structures, is a prerequisite for adequate vascular scaffold production. Capillary structures are necessary since they provide the elements and compounds for the growth, function and maintenance of 3D tissue structures. Computer-aided modeling of stereolithographic (STL) micro-computer tomographic (micro-CT) 3D models is a technique that enables us to mimic the design of vascular tree systems containing capillary beds, found in tissues. In our first paper (Mondy et al 2009 Tissue Eng. at press), using micro-CT, we studied the possibility of using vascular tissues to produce data capable of aiding the design of vascular tree scaffolding, which would help in the reverse engineering of a complete vascular tree system including capillary bed structures. In this paper, we used STL models of large datasets of computer-aided design (CAD) data of vascular structures which contained capillary structures that mimic those in the dermal layers of rabbit skin. Using CAD software we created from 3D STL models a bio-CAD design for the development of capillary-containing vascular tree scaffolding for skin. This method is designed to enhance a variety of therapeutic protocols including, but not limited to, organ and tissue repair, systemic disease mediation and cell/tissue transplantation therapy. Our successful approach to in vitro vasculogenesis will allow the bioengineering of various other types of 3D tissue structures, and as such greatly expands the potential applications of biomedical engineering technology into the fields of biomedical research and medicine.

  14. Computer-aided design of microvasculature systems for use in vascular scaffold production

    International Nuclear Information System (INIS)

    Mondy, William Lafayette; Cameron, Don; Timmermans, Jean-Pierre; De Clerck, Nora; Sasov, Alexander; Casteleyn, Christophe; Piegl, Les A

    2009-01-01

    In vitro biomedical engineering of intact, functional vascular networks, which include capillary structures, is a prerequisite for adequate vascular scaffold production. Capillary structures are necessary since they provide the elements and compounds for the growth, function and maintenance of 3D tissue structures. Computer-aided modeling of stereolithographic (STL) micro-computer tomographic (micro-CT) 3D models is a technique that enables us to mimic the design of vascular tree systems containing capillary beds, found in tissues. In our first paper (Mondy et al 2009 Tissue Eng. at press), using micro-CT, we studied the possibility of using vascular tissues to produce data capable of aiding the design of vascular tree scaffolding, which would help in the reverse engineering of a complete vascular tree system including capillary bed structures. In this paper, we used STL models of large datasets of computer-aided design (CAD) data of vascular structures which contained capillary structures that mimic those in the dermal layers of rabbit skin. Using CAD software we created from 3D STL models a bio-CAD design for the development of capillary-containing vascular tree scaffolding for skin. This method is designed to enhance a variety of therapeutic protocols including, but not limited to, organ and tissue repair, systemic disease mediation and cell/tissue transplantation therapy. Our successful approach to in vitro vasculogenesis will allow the bioengineering of various other types of 3D tissue structures, and as such greatly expands the potential applications of biomedical engineering technology into the fields of biomedical research and medicine.

  15. Computer-aided design of microvasculature systems for use in vascular scaffold production.

    Science.gov (United States)

    Mondy, William Lafayette; Cameron, Don; Timmermans, Jean-Pierre; De Clerck, Nora; Sasov, Alexander; Casteleyn, Christophe; Piegl, Les A

    2009-09-01

    In vitro biomedical engineering of intact, functional vascular networks, which include capillary structures, is a prerequisite for adequate vascular scaffold production. Capillary structures are necessary since they provide the elements and compounds for the growth, function and maintenance of 3D tissue structures. Computer-aided modeling of stereolithographic (STL) micro-computer tomographic (micro-CT) 3D models is a technique that enables us to mimic the design of vascular tree systems containing capillary beds, found in tissues. In our first paper (Mondy et al 2009 Tissue Eng. at press), using micro-CT, we studied the possibility of using vascular tissues to produce data capable of aiding the design of vascular tree scaffolding, which would help in the reverse engineering of a complete vascular tree system including capillary bed structures. In this paper, we used STL models of large datasets of computer-aided design (CAD) data of vascular structures which contained capillary structures that mimic those in the dermal layers of rabbit skin. Using CAD software we created from 3D STL models a bio-CAD design for the development of capillary-containing vascular tree scaffolding for skin. This method is designed to enhance a variety of therapeutic protocols including, but not limited to, organ and tissue repair, systemic disease mediation and cell/tissue transplantation therapy. Our successful approach to in vitro vasculogenesis will allow the bioengineering of various other types of 3D tissue structures, and as such greatly expands the potential applications of biomedical engineering technology into the fields of biomedical research and medicine.

  16. Disruption of the rice nitrate transporter OsNPF2.2 hinders root-to-shoot nitrate transport and vascular development

    Science.gov (United States)

    Li, Yuge; Ouyang, Jie; Wang, Ya-Yun; Hu, Rui; Xia, Kuaifei; Duan, Jun; Wang, Yaqin; Tsay, Yi-Fang; Zhang, Mingyong

    2015-01-01

    Plants have evolved to express some members of the nitrate transporter 1/peptide transporter family (NPF) to uptake and transport nitrate. However, little is known of the physiological and functional roles of this family in rice (Oryza sativa L.). Here, we characterized the vascular specific transporter OsNPF2.2. Functional analysis using cDNA-injected Xenopus laevis oocytes revealed that OsNPF2.2 is a low-affinity, pH-dependent nitrate transporter. Use of a green fluorescent protein tagged OsNPF2.2 showed that the transporter is located in the plasma membrane in the rice protoplast. Expression analysis showed that OsNPF2.2 is nitrate inducible and is mainly expressed in parenchyma cells around the xylem. Disruption of OsNPF2.2 increased nitrate concentration in the shoot xylem exudate when nitrate was supplied after a deprivation period; this result suggests that OsNPF2.2 may participate in unloading nitrate from the xylem. Under steady-state nitrate supply, the osnpf2.2 mutants maintained high levels of nitrate in the roots and low shoot:root nitrate ratios; this observation suggests that OsNPF2.2 is involved in root-to-shoot nitrate transport. Mutation of OsNPF2.2 also caused abnormal vasculature and retarded plant growth and development. Our findings demonstrate that OsNPF2.2 can unload nitrate from the xylem to affect the root-to-shoot nitrate transport and plant development. PMID:25923512

  17. Integrated transport and renewable energy systems

    DEFF Research Database (Denmark)

    Mathiesen, B.V.; Lund, H.; Nørgård, Per Bromand

    2007-01-01

    Governments worldwide aim at reducing CO2 emissions and expanding renewable energy. A key element in achieving such a goal is to use renewable energy in transport such as biofuels. However, efforts to promote single transport technologies and single fuels only represent a partial solution...... transport. It is concluded that a 100 per cent renewable energy transport system is possible but is connected to significant challenges in the path towards it. Biomass is a limited resource and it is important to avoid effecting the production. The integration of the transport with the remaining energy....... No single technology can solve the problem of ever increasing CO2 emissions from transport. Transport must be integrated into energy planning, as electricity and heating. In this paper, a coherent effort to integrate transport into energy planning is proposed, using multiple means promoting sustainable...

  18. Performances of the HL (Hyperloop) transport system

    OpenAIRE

    van Goeverden, C.D.; Milakis, D.; Janic, M.; Konings, J.W.; Cools, M.; Limbourg, S.

    2017-01-01

    This paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental. The operational performance include capacity and quality of service provided to the system’s users-passengers with attributes such as door-to-door travel time consisting of the access and egress ti...

  19. Analysis and comparison of transportation security systems

    International Nuclear Information System (INIS)

    Rinne, R.L.

    1976-05-01

    The role of modeling in the analysis of transportation security systems is described. Various modeling approaches are outlined. The conflict model developed in Sandia Laboratories' Transportation Mode Analysis for the NRC Special Safeguards Study is used to demonstrate the capability of models to determine system sensitivities and compare alternatives

  20. [Research progress of co-culture system for constructing vascularized tissue engineered bone].

    Science.gov (United States)

    Fu, Weili; Xiang, Zhou

    2014-02-01

    To review the research progress of the co-culture system for constructing vascularized tissue engineered bone. The recent literature concerning the co-culture system for constructing vascularized tissue engineered bone was reviewed, including the selection of osteogenic and endothelial lineages, the design and surface modification of scaffolds, the models and dimensions of the co-culture system, the mechanism, the culture conditions, and their application progress. The construction of vascularized tissue engineered bone is the prerequisite for their survival and further clinical application in vivo. Mesenchymal stem cells (owning the excellent osteogenic potential) and endothelial progenitor cells (capable of directional differentiation into endothelial cell) are considered as attractive cell types for the co-culture system to construct vascularized tissue engineered bone. The culture conditions need to be further optimized. Furthermore, how to achieve the clinical goals of minimal invasion and autologous transplantation also need to be further studied. The strategy of the co-culture system for constructing vascularized tissue engineered bone would have a very broad prospects for clinical application in future.

  1. Nitric oxide signaling and the cross talk with prostanoids pathways in vascular system.

    Science.gov (United States)

    Silva, Bruno R; Paula, Tiago D; Paulo, Michele; Bendhack, Lusiane M

    2016-12-28

    This review provides an overview of the cellular signaling of nitric oxide (NO) and prostanoids in vascular cells and the possible cross talk between their pathways, mainly in hypertension, since the imbalance of these two systems has been attributed to development of some cardiovascular diseases. It also deals with the modulation of vasodilation induced by NO donors. NO is a well-known second messenger involved in many cellular functions. In the vascular system, the NO produced by endothelial NO-synthase (eNOS) or released by NO donors acts in vascular smooth muscle cells, the binding of NO to Fe2+-heme of soluble guanylyl-cyclase (sGC) activates sGC and the production of cyclic guanosine-3-5-monophosphate (cGMP). The second messenger (cGMP) activates protein kinase G and the signaling cascade, including K+ channels. Activation of K+ channels leads to cell membrane hyperpolarization and Ca2+ channels blockade, which induce vascular relaxation. Moreover, the enzyme cyclooxygenase (COX) is also an important regulator of the vascular function by prostanoids production such as thromboxane A2 (TXA2) and prostacyclin (PGI2), which classically induce contraction and relaxation, respectively. Additionaly, studies indicate that the activity of both enzymes can be modulated by their products and reactive oxygen species (ROS) in cardiovascular diseases such as hypertension. The interaction of NO with cellular molecules, particularly the reaction of NO with ROS, determines the biological mechanisms of action and short half-life of NO. We have been working on the vascular effects of ruthenium-derived complexes that release NO. Our research group has published works on the vasodilating effects of ruthenium-derived NO donors and the mechanisms of vascular cells involved in the relaxation of the vascular smooth muscle in health and hypertensive rats. In our previous studies, we have compared the new NO donors synthesized by our group to SNP. It shows the cellular signaling of NO

  2. The transportation operations system: A description

    International Nuclear Information System (INIS)

    Best, R.E.; Danese, F.L.; Dixon, L.D.; Peterson, R.W.; Pope, R.B.

    1990-01-01

    This paper presents a description of the system for transporting radioactive waste that may be deployed to accomplish the assigned system mission, which includes accepting spent nuclear fuel (SNF) and high-level radioactive waste (HLW) from waste generator sites and transporting them to the FWMS destination facilities. The system description presented here contains, in part, irradiated fuel and waste casks, ancillary equipments, truck, rail, and barge transporters, cask and vehicle traffic management organizations, maintenance facilities, and other operations elements. The description is for a fully implemented system, which is not expected to be achieved, however, until several years after initial operations. 6 figs

  3. Sensor Technologies for Intelligent Transportation Systems.

    Science.gov (United States)

    Guerrero-Ibáñez, Juan; Zeadally, Sherali; Contreras-Castillo, Juan

    2018-04-16

    Modern society faces serious problems with transportation systems, including but not limited to traffic congestion, safety, and pollution. Information communication technologies have gained increasing attention and importance in modern transportation systems. Automotive manufacturers are developing in-vehicle sensors and their applications in different areas including safety, traffic management, and infotainment. Government institutions are implementing roadside infrastructures such as cameras and sensors to collect data about environmental and traffic conditions. By seamlessly integrating vehicles and sensing devices, their sensing and communication capabilities can be leveraged to achieve smart and intelligent transportation systems. We discuss how sensor technology can be integrated with the transportation infrastructure to achieve a sustainable Intelligent Transportation System (ITS) and how safety, traffic control and infotainment applications can benefit from multiple sensors deployed in different elements of an ITS. Finally, we discuss some of the challenges that need to be addressed to enable a fully operational and cooperative ITS environment.

  4. Sensor Technologies for Intelligent Transportation Systems

    Science.gov (United States)

    Guerrero-Ibáñez, Juan; Zeadally, Sherali

    2018-01-01

    Modern society faces serious problems with transportation systems, including but not limited to traffic congestion, safety, and pollution. Information communication technologies have gained increasing attention and importance in modern transportation systems. Automotive manufacturers are developing in-vehicle sensors and their applications in different areas including safety, traffic management, and infotainment. Government institutions are implementing roadside infrastructures such as cameras and sensors to collect data about environmental and traffic conditions. By seamlessly integrating vehicles and sensing devices, their sensing and communication capabilities can be leveraged to achieve smart and intelligent transportation systems. We discuss how sensor technology can be integrated with the transportation infrastructure to achieve a sustainable Intelligent Transportation System (ITS) and how safety, traffic control and infotainment applications can benefit from multiple sensors deployed in different elements of an ITS. Finally, we discuss some of the challenges that need to be addressed to enable a fully operational and cooperative ITS environment. PMID:29659524

  5. Sensor Technologies for Intelligent Transportation Systems

    Directory of Open Access Journals (Sweden)

    Juan Guerrero-Ibáñez

    2018-04-01

    Full Text Available Modern society faces serious problems with transportation systems, including but not limited to traffic congestion, safety, and pollution. Information communication technologies have gained increasing attention and importance in modern transportation systems. Automotive manufacturers are developing in-vehicle sensors and their applications in different areas including safety, traffic management, and infotainment. Government institutions are implementing roadside infrastructures such as cameras and sensors to collect data about environmental and traffic conditions. By seamlessly integrating vehicles and sensing devices, their sensing and communication capabilities can be leveraged to achieve smart and intelligent transportation systems. We discuss how sensor technology can be integrated with the transportation infrastructure to achieve a sustainable Intelligent Transportation System (ITS and how safety, traffic control and infotainment applications can benefit from multiple sensors deployed in different elements of an ITS. Finally, we discuss some of the challenges that need to be addressed to enable a fully operational and cooperative ITS environment.

  6. RGB imaging system for monitoring of skin vascular malformation's laser therapy

    Science.gov (United States)

    Jakovels, Dainis; Kuzmina, Ilona; Berzina, Anna; Spigulis, Janis

    2012-06-01

    A prototype RGB imaging system for mapping of skin chromophores consists of a commercial RGB CMOS sensor, RGB LEDs ring-light illuminator and orthogonally orientated polarizers for reducing specular reflectance. The system was used for monitoring of vascular malformations (hemagiomas and telangiectasias) therapy.

  7. Driverless operation for public passenger transport systems

    Energy Technology Data Exchange (ETDEWEB)

    Kehl, R. [Siemens AG, Erlangen (Germany). Bereich Verkehrstechnik

    2001-07-01

    The author presents the automation of new and existing lines as a possible solution to the twin problems of the growing need for public transport and the threat of collapse facing many public transport systems in the big conurbations as they wrestle against overloading. It emerges that automatic, driverless operation is a suitable approach to making systems more flexible and more attractive. Automation can increase the capacities of existing systems significantly and thus help them gain more passengers. (orig.)

  8. Operating control techniques for maglev transport systems

    Energy Technology Data Exchange (ETDEWEB)

    Kraft, K H; Schnieder, E

    1984-06-01

    The technical and operational possibilities of magnetic levitation transport systems can only be fully exploited by introducing 'intelligent' control systems which ensure automatic and trouble-free train running. The solution of exacting requirements in the fields of traction dynamics, security and control as well as information gathering transmission and processing is an important prior condition in that respect. The authors report here on the present state of research and development in operating control techniques applicable to maglev transport systems.

  9. 49 CFR 37.33 - Airport transportation systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Airport transportation systems. 37.33 Section 37.33 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.33 Airport transportation systems. (a) Transportation...

  10. Integrated design for space transportation system

    CERN Document Server

    Suresh, B N

    2015-01-01

    The book addresses the overall integrated design aspects of a space transportation system involving several disciplines like propulsion, vehicle structures, aerodynamics, flight mechanics, navigation, guidance and control systems, stage auxiliary systems, thermal systems etc. and discusses the system approach for design, trade off analysis, system life cycle considerations, important aspects in mission management, the risk assessment, etc. There are several books authored to describe the design aspects of various areas, viz., propulsion, aerodynamics, structures, control, etc., but there is no book which presents space transportation system (STS) design in an integrated manner. This book attempts to fill this gap by addressing systems approach for STS design, highlighting the integrated design aspects, interactions between various subsystems and interdependencies. The main focus is towards the complex integrated design to arrive at an optimum, robust and cost effective space transportation system. The orbit...

  11. The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary

    Directory of Open Access Journals (Sweden)

    Masatake Tanaka

    2016-11-01

    Full Text Available The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues. Keywords: VEGF, Inflammation, Cirrhosis, Portal Hypertension

  12. Systemic and Disease-Specific Risk Factors in Vascular Dementia: Diagnosis and Prevention

    Directory of Open Access Journals (Sweden)

    Efraim Jaul

    2017-10-01

    Full Text Available In order to prevent the onset of vascular dementia (VaD in aging individuals, it is critical to detect clinically relevant vascular and systemic pathophysiological changes to signal the onset of its preceding prodromal stages. Identifying behavioral and neurobiological markers that are highly sensitive to VaD classification vs. other dementias is likely to assist in developing novel preventive treatment strategies that could delay the onset of disruptive psychomotor symptoms, decrease hospitalizations, and increase the quality of life in clinically-high-risk aging individuals. In light of empirical diagnostic and clinical findings associated with VaD pathophysiology, the current investigation will suggest a few clinically-validated biomarker measures of prodromal VaD cognitive impairments that are correlated with vascular symptomology, and VaD endophenotypes in non-demented aging people. In prodromal VaD individuals, distinguishing VaD from other dementias (e.g., Alzheimer's disease could facilitate specific early preventive interventions that significantly delay more severe cognitive deterioration or indirectly suppress the onset of dementia with vascular etiology. Importantly, the authors conclude that primary prevention strategies should examine aging individuals by employing comprehensive geriatric assessment approach, taking into account their medical history, and longitudinally noting their vascular, systemic, cognitive, behavioral, and clinical functional status. Secondary prevention strategies may include monitoring chronic medication as well as promoting programs that facilitate social interaction and every-day activities.

  13. Lean manufacturing and Toyota Production System terminology applied to the procurement of vascular stents in interventional radiology.

    Science.gov (United States)

    de Bucourt, Maximilian; Busse, Reinhard; Güttler, Felix; Wintzer, Christian; Collettini, Federico; Kloeters, Christian; Hamm, Bernd; Teichgräber, Ulf K

    2011-08-01

    OBJECTIVES: To apply the economic terminology of lean manufacturing and the Toyota Production System to the procurement of vascular stents in interventional radiology. METHODS: The economic- and process-driven terminology of lean manufacturing and the Toyota Production System is first presented, including information and product flow as well as value stream mapping (VSM), and then applied to an interdisciplinary setting of physicians, nurses and technicians from different medical departments to identify wastes in the process of endovascular stent procurement in interventional radiology. RESULTS: Using the so-called seven wastes approach of the Toyota Production System (waste of overproducing, waiting, transport, processing, inventory, motion and waste of defects and spoilage) as well as further waste characteristics (gross waste, process and method waste, and micro waste), wastes in the process of endovascular stent procurement in interventional radiology were identified and eliminated to create an overall smoother process from the procurement as well as from the medical perspective. CONCLUSION: Economic terminology of lean manufacturing and the Toyota Production System, especially VSM, can be used to visualise and better understand processes in the procurement of vascular stents in interventional radiology from an economic point of view.

  14. Mass Transport: Circulatory System with Emphasis on Nonendothermic Species.

    Science.gov (United States)

    Crossley, Dane A; Burggren, Warren W; Reiber, Carl L; Altimiras, Jordi; Rodnick, Kenneth J

    2016-12-06

    Mass transport can be generally defined as movement of material matter. The circulatory system then is a biological example given its role in the movement in transporting gases, nutrients, wastes, and chemical signals. Comparative physiology has a long history of providing new insights and advancing our understanding of circulatory mass transport across a wide array of circulatory systems. Here we focus on circulatory function of nonmodel species. Invertebrates possess diverse convection systems; that at the most complex generate pressures and perform at a level comparable to vertebrates. Many invertebrates actively modulate cardiovascular function using neuronal, neurohormonal, and skeletal muscle activity. In vertebrates, our understanding of cardiac morphology, cardiomyocyte function, and contractile protein regulation by Ca2+ highlights a high degree of conservation, but differences between species exist and are coupled to variable environments and body temperatures. Key regulators of vertebrate cardiac function and systemic blood pressure include the autonomic nervous system, hormones, and ventricular filling. Further chemical factors regulating cardiovascular function include adenosine, natriuretic peptides, arginine vasotocin, endothelin 1, bradykinin, histamine, nitric oxide, and hydrogen sulfide, to name but a few. Diverse vascular morphologies and the regulation of blood flow in the coronary and cerebral circulations are also apparent in nonmammalian species. Dynamic adjustments of cardiovascular function are associated with exercise on land, flying at high altitude, prolonged dives by marine mammals, and unique morphology, such as the giraffe. Future studies should address limits of gas exchange and convective transport, the evolution of high arterial pressure across diverse taxa, and the importance of the cardiovascular system adaptations to extreme environments. © 2017 American Physiological Society. Compr Physiol 7:17-66, 2017. Copyright © 2017 John

  15. RELIABILITY OF TRANSPORTATION SYSTEMS OF ROCK HAPS

    Directory of Open Access Journals (Sweden)

    A. Stepanov

    2009-01-01

    Full Text Available The ways of increasing of exploitation reliability of dump trucks with the aim of increasing of effectiveness of exploitation of transportation systems of rock heaps at coal mines.

  16. Intelligent Transportation Systems statewide architecture : final report.

    Science.gov (United States)

    2003-06-01

    This report describes the development of Kentuckys Statewide Intelligent Transportation Systems (ITS) Architecture. The process began with the development of an ITS Strategic Plan in 1997-2000. A Business Plan, developed in 2000-2001, translated t...

  17. Methane transport and emissions from soil as affected by water table and vascular plants.

    Science.gov (United States)

    Bhullar, Gurbir S; Iravani, Majid; Edwards, Peter J; Olde Venterink, Harry

    2013-09-08

    The important greenhouse gas (GHG) methane is produced naturally in anaerobic wetland soils. By affecting the production, oxidation and transport of methane to the atmosphere, plants have a major influence upon the quantities emitted by wetlands. Different species and functional plant groups have been shown to affect these processes differently, but our knowledge about how these effects are influenced by abiotic factors such as water regime and temperature remains limited. Here we present a mesocosm experiment comparing eight plant species for their effects on internal transport and overall emissions of methane under contrasting hydrological conditions. To quantify how much methane was transported internally through plants (the chimney effect), we blocked diffusion from the soil surface with an agar seal. We found that graminoids caused higher methane emissions than forbs, although the emissions from mesocosms with different species were either lower than or comparable to those from control mesocosms with no plant (i.e. bare soil). Species with a relatively greater root volume and a larger biomass exhibited a larger chimney effect, though overall methane emissions were negatively related to plant biomass. Emissions were also reduced by lowering the water table. We conclude that plant species (and functional groups) vary in the degree to which they transport methane to the atmosphere. However, a plant with a high capacity to transport methane does not necessarily emit more methane, as it may also cause more rhizosphere oxidation of methane. A shift in plant species composition from graminoids to forbs and/or from low to high productive species may lead to reduction of methane emissions.

  18. The challenge of establishing treatment efficacy for cutaneous vascular manifestations of systemic sclerosis.

    Science.gov (United States)

    Pauling, John D

    2018-05-01

    The cutaneous vascular manifestations of systemic sclerosis (SSc) comprise Raynaud's phenomenon, cutaneous ulceration, telangiectasia formation and critical digital ischaemia; each of which are associated with significant disease-related morbidity. Despite the availability of multiple classes of vasodilator therapy, many of which have been the subject of RCTs, a limited number of pharmacological interventions are currently approved for the management of cutaneous vascular manifestations of SSc. Areas covered: A major challenge has been demonstrating treatment efficacy with examples of promising therapies yielding contrasting results in controlled trial settings. Differences between consensus best-practice guidelines, evidence-based recommendations and marketing approvals in different jurisdictions has resulted in geographic variation in clinical practice concerning the management of cutaneous vascular manifestations of SSc. Difficulty demonstrating treatment efficacy risks waning industry engagement for drug development programmes in this field. This article highlights the key challenges in establishing treatment efficacy and barriers that must be overcome to support successful clinical trial programmes across the spectrum of cutaneous vascular manifestations of SSc. Expert commentary: The paucity of approved treatments for cutaneous vascular manifestations of SSc relates as much to challenges in clinical trial design and the need for reliable clinical trial endpoints, as to lack of therapeutic options.

  19. A case of vascular Ehlers-Danlos Syndrome with a cardiomyopathy and multi-system involvement.

    Science.gov (United States)

    Lan, Nick Si Rui; Fietz, Michael; Pachter, Nicholas; Paul, Vincent; Playford, David

    Ehlers-Danlos Syndrome comprises a heterogeneous group of heritable connective tissue disorders resulting from various gene mutations. We present an unusual case of vascular Ehlers-Danlos Syndrome with distinctive physical characteristics and a cardiomyopathy with features suggesting isolated left ventricular non-compaction. The cardiac features represent the first report of a cardiomyopathy associated with a mutation in the COL3A1 gene. This case also illustrates the multi-system nature of Ehlers-Danlos Syndrome and the complexity of managing patients with the vascular subtype. Copyright © 2018 Elsevier Inc. All rights reserved.

  20. Evolutionary morphology of the hemolymph vascular system of basal araneomorph spiders (Araneae: Araneomorphae).

    Science.gov (United States)

    Huckstorf, Katarina; Michalik, Peter; Ramírez, Martín; Wirkner, Christian S

    2015-11-01

    The superfamily Austrochiloidea (Austrochilidae and Gradungulidae) take a pivotal position in araneomorph spider phylogeny. In this discussion crevice weaver spiders (Filistatidae) are of equal interest. Especially data from these phylogenetically uncertain yet basal off branching groups can enlighten our understanding on the evolution of organ systems. In the course of a survey on the evolutionary morphology of the circulatory system in spiders we therefore investigated the hemolymph vascular system in two austrochiloid and one filistatid species. Additionally some data on a hypochilid and a gradungulid species are included. Using up-to-date morphological methods, the vascular systems in these spiders are visualized three dimensionally. Ground pattern features of the circulatory systems in austrochiloid spiders are presented and the data discussed along recent lines of phylogenetic hypotheses. Special topics highlighted are the intraspecific variability of the origins of some prosomal arteries and the evolutionary correlation of respiratory and circulatory systems in spiders. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Systemic Analysis Approaches for Air Transportation

    Science.gov (United States)

    Conway, Sheila

    2005-01-01

    Air transportation system designers have had only limited success using traditional operations research and parametric modeling approaches in their analyses of innovations. They need a systemic methodology for modeling of safety-critical infrastructure that is comprehensive, objective, and sufficiently concrete, yet simple enough to be used with reasonable investment. The methodology must also be amenable to quantitative analysis so issues of system safety and stability can be rigorously addressed. However, air transportation has proven itself an extensive, complex system whose behavior is difficult to describe, no less predict. There is a wide range of system analysis techniques available, but some are more appropriate for certain applications than others. Specifically in the area of complex system analysis, the literature suggests that both agent-based models and network analysis techniques may be useful. This paper discusses the theoretical basis for each approach in these applications, and explores their historic and potential further use for air transportation analysis.

  2. Proangiogenic hematopoietic cells of monocytic origin: roles in vascular regeneration and pathogenic processes of systemic sclerosis.

    Science.gov (United States)

    Yamaguchi, Yukie; Kuwana, Masataka

    2013-02-01

    New blood vessel formation is critical, not only for organ development and tissue regeneration, but also for various pathologic processes, such as tumor development and vasculopathy. The maintenance of the postnatal vascular system requires constant remodeling, which occurs through angiogenesis, vasculogenesis, and arteriogenesis. Vasculogenesis is mediated by the de novo differentiation of mature endothelial cells from endothelial progenitor cells (EPCs). Early studies provided evidence that bone marrow-derived CD14⁺ monocytes can serve as a subset of EPCs because of their expression of endothelial markers and ability to promote neovascularization in vitro and in vivo. However, the current consensus is that monocytic cells do not give rise to endothelial cells in vivo, but function as support cells, by promoting vascular formation and repair through their immediate recruitment to the site of vascular injury, secretion of proangiogenic factors, and differentiation into mural cells. These monocytes that function in a supporting role in vascular repair are now termed monocytic pro-angiogenic hematopoietic cells (PHCs). Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by excessive fibrosis and microvasculopathy, along with poor vascular formation and repair. We recently showed that in patients with SSc, circulating monocytic PHCs increase dramatically and have enhanced angiogenic potency. These effects may be induced in response to defective vascular repair machinery. Since CD14⁺ monocytes can also differentiate into fibroblast-like cells that produce extracellular matrix proteins, here we propose a new hypothesis that aberrant monocytic PHCs, once mobilized into circulation, may also contribute to the fibrotic process of SSc.

  3. Gastric antral vascular ectasia--a cause of refractory anaemia in systemic sclerosis.

    LENUS (Irish Health Repository)

    Busteed, S

    2012-02-03

    Recurrent gastrointestinal haemorrhage is an uncommon manifestation of systemic sclerosis. We report a case of gastrointestinal bleeding due to gastric antral vascular ectasia (GAVE) in a patient with systemic sclerosis. Failure to recognise the condition as a cause of gastrointestinal bleeding may delay the instigation of appropriate treatment. GAVE should be considered in the differential diagnosis of anaemia in patients with autoimmune conditions such as systemic sclerosis and primary biliary cirrhosis.

  4. The WIPP transportation system: Dedicated to safety

    International Nuclear Information System (INIS)

    Ward, T.; McFadden, M.

    1993-01-01

    When developing a transportation system to transport transuranic (TRU) waste from ten widely-dispersed generator sites, the Department of Energy (DOE) recognized and addressed many challenges. Shipments of waste to the Waste Isolation Pilot Plant (WIPP) were to cover a twenty-five year period and utilize routes covering over twelve thousand miles in twenty-three states. Enhancing public safety by maximizing the payload, thus reducing the number of shipments, was the primary objective. To preclude the requirement for overweight permits, the DOE started with a total shipment weight limit of 80,000 pounds and developed an integrated transportation system consisting of a Type ''B'' package to transport the material, a lightweight tractor and trailer, stringent driver requirements, and a shipment tracking system referred to as ''TRANSCOM''

  5. Methane transport and emissions from soil as affected by water table and vascular plants

    OpenAIRE

    Bhullar, Gurbir S; Iravani, Majid; Edwards, Peter J; Olde Venterink, Harry

    2013-01-01

    Background: The important greenhouse gas (GHG) methane is produced naturally in anaerobic wetland soils. By affecting the production, oxidation and transport of methane to the atmosphere, plants have a major influence upon the quantities emitted by wetlands. Different species and functional plant groups have been shown to affect these processes differently, but our knowledge about how these effects are influenced by abiotic factors such as water regime and temperature remains limited. Here...

  6. The WIPP transportation system: Demonstrated readiness

    International Nuclear Information System (INIS)

    Ward, T.R.; Spooner, R.

    1991-01-01

    The Department of Energy (DOE) has developed an integrated transportation system to transport transuranic (TRU) waste from ten widely-dispersed generator sites to the Waste Isolation Pilot Plant (WIPP). The system consists of a Type B container, a specially- designed trailer, a lightweight tractor, the DOE ''TRANSCOM'' vehicle tracking system, and uniquely qualified and highly-trained drivers. In June of 1989, the National Academy of Sciences reviewed the transportation system and concluded that: ''The system proposed for transportation of TRU waste to WIPP is safer than that employed for any other hazardous material in the United States today and will reduce risk to very low levels'' (emphasis added). The next challenge facing the DOE was demonstrating that this system was ready to transport the TRU waste to the WIPP site efficiently and in the safest manner possible. Not only did the DOE feel that is was necessary to convince itself that the system was safe, but also representatives of the 20 states through which it would travel

  7. The WIPP transportation system: Demonstrated readiness

    International Nuclear Information System (INIS)

    Ward, T.R.; Spooner, R.

    1991-01-01

    The Department of Energy (DOE) has developed an integrated transportation system to transport transuranic (TRU) waste from ten widely-dispersed generator sites to the Waste Isolation Pilot Plant (WIPP). The system consists of a Type B container, a specially-designed trailer, a lightweight tractor, the DOE ''TRANSCOM'' vehicle tracing system, and uniquely qualified and highly-trained drivers. In June of 1989, the National Academy of Sciences reviewed the transportation system and concluded that: ''The system proposed for transportation of TRU waste to WIPP is safer than that employed for any other hazardous material in the United States today and will reduce risk to very low levels.'' The next challenge facing the DOE was demonstrating that this system was ready to transport the TRU waste to the WIPP site in the safest manner possible. Not only did the DOE feel that it was necessary to convince itself that the system was safe, but also representatives of the 23 states through which it traveled

  8. 49 CFR 37.25 - University transportation systems.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false University transportation systems. 37.25 Section 37.25 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Applicability § 37.25 University transportation systems. (a...

  9. Quantum Transport in Mesoscopic Systems

    Indian Academy of Sciences (India)

    voltage bias, the tunneling of the electron from the lead to the dot and vice versa will happen very rarely. Then two successive ..... A typical mesoscopic quantum dot system (a small drop- .... dynamical behavior of the distribution function of the.

  10. Inactive trials of transport systems: phase II

    International Nuclear Information System (INIS)

    Haberlin, M.M.; Hardy, A.R.; Kennedy, S.T.

    1986-11-01

    Progress made during 1984-85 is reviewed in four sections: the design and installation of a stainless steel working floor in the mock-up of a crate handling and size reduction facility; the detailed evaluation of a single air pad of the type used on commercial air-transporter; an experimental programme designed to examine the problems associated with the operation of a commercial air-transporter; the design, manufacture and commissioning trials of two powered conveyor units which when combined complete a remotely operated transfer system for transporting crated waste into and within the mock-up facility. (author)

  11. Not planning a sustainable transport system

    International Nuclear Information System (INIS)

    Finnveden, Göran; Åkerman, Jonas

    2014-01-01

    The overall objective of the Swedish transport policy is to ensure the economically efficient and sustainable provision of transport services for people and business throughout the country. More specifically, the transport sector shall, among other things, contribute to the achievement of environmental quality objectives in which the development of the transport system plays an important role in the achievement of the objectives. The aim of this study is to analyse if current transport planning supports this policy. This is done by analysing two recent cases: the National Infrastructure Plan 2010–2021, and the planning of Bypass Stockholm, a major road investment. Our results show that the plans are in conflict with several of the environmental quality objectives. Another interesting aspect of the planning processes is that the long-term climate goals are not included in the planning processes, neither as a clear goal nor as factor that will influence future transport systems. In this way, the long-term sustainability aspects are not present in the planning. We conclude that the two cases do not contribute to a sustainable transport system. Thus, several changes must be made in the processes, including putting up clear targets for emissions. Also, the methodology for the environmental assessments needs to be further developed and discussed. - Highlights: • Two cases are studied to analyse if current planning supports a sustainable transport system. • Results show that the plans are in conflict with several of the environmental quality objectives. • Long-term climate goals are not included in the planning processes. • Current practices do not contribute to a sustainable planning processes. • Methodology and process for environmental assessments must be further developed and discussed

  12. Not planning a sustainable transport system

    Energy Technology Data Exchange (ETDEWEB)

    Finnveden, Göran, E-mail: goran.finnveden@abe.kth.se; Åkerman, Jonas

    2014-04-01

    The overall objective of the Swedish transport policy is to ensure the economically efficient and sustainable provision of transport services for people and business throughout the country. More specifically, the transport sector shall, among other things, contribute to the achievement of environmental quality objectives in which the development of the transport system plays an important role in the achievement of the objectives. The aim of this study is to analyse if current transport planning supports this policy. This is done by analysing two recent cases: the National Infrastructure Plan 2010–2021, and the planning of Bypass Stockholm, a major road investment. Our results show that the plans are in conflict with several of the environmental quality objectives. Another interesting aspect of the planning processes is that the long-term climate goals are not included in the planning processes, neither as a clear goal nor as factor that will influence future transport systems. In this way, the long-term sustainability aspects are not present in the planning. We conclude that the two cases do not contribute to a sustainable transport system. Thus, several changes must be made in the processes, including putting up clear targets for emissions. Also, the methodology for the environmental assessments needs to be further developed and discussed. - Highlights: • Two cases are studied to analyse if current planning supports a sustainable transport system. • Results show that the plans are in conflict with several of the environmental quality objectives. • Long-term climate goals are not included in the planning processes. • Current practices do not contribute to a sustainable planning processes. • Methodology and process for environmental assessments must be further developed and discussed.

  13. Transportable Vitrification System Demonstration on Mixed Waste

    International Nuclear Information System (INIS)

    Zamecnik, J.R.; Whitehouse, J.C.; Wilson, C.N.; Van Ryn, F.R.

    1998-01-01

    This paper describes preliminary results from the first demonstration of the Transportable Vitrification System (TVS) on actual mixed waste. The TVS is a fully integrated, transportable system for the treatment of mixed and low-level radioactive wastes. The demonstration was conducted at Oak Ridge's East Tennessee Technology Park (ETTP), formerly known as the K-25 site. The purpose of the demonstration was to show that mixed wastes could be vitrified safely on a 'field' scale using joule-heated melter technology and obtain information on system performance, waste form durability, air emissions, and costs

  14. A consonant construction of the hyaloid and retinal vascular systems by the angiogenic process.

    Science.gov (United States)

    Gergely, K; Gerinec, A

    2011-01-01

    There has been much debate as to whether the retinal vasculature forms by angiogenesis or vasculogenesis, thus angiogenesis is now accepted. We suppose that signals necessary for proper localization and development of the hyaloid and retinal vascular systems are already in place prior to the time at which these systems are developed. The remarkable conservation of vascular patterning suggests that specific genetic programs coordinate its formation. Evidence for a genetic program comes particularly from the characterization of gene-targeted mice and mutational analysis in zebrafish, but the exact genetic pathways remain poorly defined. Considering all the things from the aspect of angiogenesis significant differences exist between the mentioned vascular systems only in their lifetime (a) and location (b): (a) The hyaloid vasculature is a complex of transient intraocular vessels, while the retinal vessels are adapted for the whole life. (b) The hyaloid system fills the interior of the optic cup and this way "occupies" three-dimensional space while the distribution of the retinal vessels is relatively planar (two-dimensional) in the retina. We assume that retinal vessels are "built" in the same manner as the hyaloid vasculature and the outcomes at the embryological, histological, cellular and molecular levels confirm it. We show a consonant construction of both systems. The human organism does not have any rational reason to build up one system (i.e. the hyaloid vasculature) by angiogenesis and practically the same system (i.e. the retinal vessels) by another, de novo process, in the eye. It would be a waste of energy and various essential molecules. Thus, it seems that the retinal vascular system is an advanced copy of the hyaloid vessels (Tab. 1, Ref. 143).

  15. Pathogen transport in groundwater systems: contrasts with traditional solute transport

    Science.gov (United States)

    Hunt, Randall J.; Johnson, William P.

    2017-06-01

    Water quality affects many aspects of water availability, from precluding use to societal perceptions of fit-for-purpose. Pathogen source and transport processes are drivers of water quality because they have been responsible for numerous outbreaks resulting in large economic losses due to illness and, in some cases, loss of life. Outbreaks result from very small exposure (e.g., less than 20 viruses) from very strong sources (e.g., trillions of viruses shed by a single infected individual). Thus, unlike solute contaminants, an acute exposure to a very small amount of contaminated water can cause immediate adverse health effects. Similarly, pathogens are larger than solutes. Thus, interactions with surfaces and settling become important even as processes important for solutes such as diffusion become less important. These differences are articulated in "Colloid Filtration Theory", a separate branch of pore-scale transport. Consequently, understanding pathogen processes requires changes in how groundwater systems are typically characterized, where the focus is on the leading edges of plumes and preferential flow paths, even if such features move only a very small fraction of the aquifer flow. Moreover, the relatively short survival times of pathogens in the subsurface require greater attention to very fast (solute transport mechanisms discussed here, a more encompassing view of water quality and source water protection is attained. With this more holistic view and theoretical understanding, better evaluations can be made regarding drinking water vulnerability and the relation between groundwater and human health.

  16. High-Energy Beam Transport system

    International Nuclear Information System (INIS)

    Melson, K.E.; Farrell, J.A.; Liska, D.J.

    1979-01-01

    The High-Energy Beam Transport (HEBT) system for the Fusion Materials Irradiation Test (FMIT) Facility is to be installed at the Hanford Engineering Development Laboratory (HEDL) at Richland, Washington. The linear accelerator must transport a large emittance, high-current, high-power, continuous-duty deuteron beam with a large energy spread either to a lithium target or a beam stop. A periodic quadrupole and bending-magnet system provides the beam transport and focusing on target with small beam aberrations. A special rf cavity distributes the energy in the beam so that the Bragg Peak is distributed within the lithium target. Operation of the rf control system, the Energy Dispersion Cavity (EDC), and the beam transport magnets is tested on the beam stop during accelerator turn-on. Characterizing the beam will require extensions of beam diagnostic techniques and noninterceptive sensors. Provisions are being made in the facility for suspending the transport system from overhead supports using a cluster system to simplify maintenance and alignment techniques

  17. Advanced public transportation systems : evaluation guidelines

    Science.gov (United States)

    1994-01-01

    The Federal Transit Administration has developed the Advanced Public Transportation Systems (APTS) Program which is an integral part of the overall U.S. DOT Intelligent Vehicle Highway Systems (IVHS) effort. A major aim of the APTS Program is to prom...

  18. Carbon transport in sodium systems

    International Nuclear Information System (INIS)

    Martin Espigares, M.; Lapena, J.; La Torre, M. de

    1983-01-01

    Carbon activities in dynamic non isothermal sodium system are determined using an equilibratium method. Foils of Fe-18 w% Cr-8 W% Ni alloy with low carbon content (in the as received condition) are exposed to dynamic liquid sodium in the temperature range between 450 0 C and 700 0 C. The analysis was used to evaluate the carburization-decarburization behaviour of type 304 stainless steel exposed to sodium. (author)

  19. The Integrated Air Transportation System Evaluation Tool

    Science.gov (United States)

    Wingrove, Earl R., III; Hees, Jing; Villani, James A.; Yackovetsky, Robert E. (Technical Monitor)

    2002-01-01

    Throughout U.S. history, our nation has generally enjoyed exceptional economic growth, driven in part by transportation advancements. Looking forward 25 years, when the national highway and skyway systems are saturated, the nation faces new challenges in creating transportation-driven economic growth and wealth. To meet the national requirement for an improved air traffic management system, NASA developed the goal of tripling throughput over the next 20 years, in all weather conditions while maintaining safety. Analysis of the throughput goal has primarily focused on major airline operations, primarily through the hub and spoke system.However, many suggested concepts to increase throughput may operate outside the hub and spoke system. Examples of such concepts include the Small Aircraft Transportation System, civil tiltrotor, and improved rotorcraft. Proper assessment of the potential contribution of these technologies to the domestic air transportation system requires a modeling capability that includes the country's numerous smaller airports, acting as a fundamental component of the National Air space System, and the demand for such concepts and technologies. Under this task for NASA, the Logistics Management Institute developed higher fidelity demand models that capture the interdependence of short-haul air travel with other transportation modes and explicitly consider the costs of commercial air and other transport modes. To accomplish this work, we generated forecasts of the distribution of general aviation based aircraft and GA itinerant operations at each of nearly 3.000 airport based on changes in economic conditions and demographic trends. We also built modules that estimate the demand for travel by different modes, particularly auto, commercial air, and GA. We examined GA demand from two perspectives: top-down and bottom-up, described in detail.

  20. Effects of heavy-ion radiation on the brain vascular system

    International Nuclear Information System (INIS)

    Yang, T.C.; Craise, L.M.; Tobias, C.A.

    1985-01-01

    In the laboratory, the authors have been studying the effects of heavy-ion radiation on the vascular system, using neonatal rats as a model system. They investigated the response of the brain vascular system to ionizing radiation and found that distinct petechial hemorrhages developed in the cerebral cortex within a few hours after irradiation, reached a maximum after about 13 to 24 hours, and then decreased exponentially with time. No brain hemorrhage was found in neonatal rats 12 days after irradiation. Heavy ions induce more hemorrhages than x rays for a given dose, and the RBE for 670-MeV/u neon particles ranges from about 2.0 for low doses to about 1.4 for high doses

  1. Human Vascular Microphysiological System for in vitro Drug Screening.

    Science.gov (United States)

    Fernandez, C E; Yen, R W; Perez, S M; Bedell, H W; Povsic, T J; Reichert, W M; Truskey, G A

    2016-02-18

    In vitro human tissue engineered human blood vessels (TEBV) that exhibit vasoactivity can be used to test human toxicity of pharmaceutical drug candidates prior to pre-clinical animal studies. TEBVs with 400-800 μM diameters were made by embedding human neonatal dermal fibroblasts or human bone marrow-derived mesenchymal stem cells in dense collagen gel. TEBVs were mechanically strong enough to allow endothelialization and perfusion at physiological shear stresses within 3 hours after fabrication. After 1 week of perfusion, TEBVs exhibited endothelial release of nitric oxide, phenylephrine-induced vasoconstriction, and acetylcholine-induced vasodilation, all of which were maintained up to 5 weeks in culture. Vasodilation was blocked with the addition of the nitric oxide synthase inhibitor L-N(G)-Nitroarginine methyl ester (L-NAME). TEBVs elicited reversible activation to acute inflammatory stimulation by TNF-α which had a transient effect upon acetylcholine-induced relaxation, and exhibited dose-dependent vasodilation in response to caffeine and theophylline. Treatment of TEBVs with 1 μM lovastatin for three days prior to addition of Tumor necrosis factor - α (TNF-α) blocked the injury response and maintained vasodilation. These results indicate the potential to develop a rapidly-producible, endothelialized TEBV for microphysiological systems capable of producing physiological responses to both pharmaceutical and immunological stimuli.

  2. LCLS-II CRYOMODULE TRANSPORT SYSTEM TESTING

    Energy Technology Data Exchange (ETDEWEB)

    Huque, Naeem [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Daly, Edward F. [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); McGee, Michael W. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2018-04-01

    The Cryomodules (CM) for the Linear Coherent Light Source II (LCLS-II) will be shipped to SLAC (Menlo Park, California) from JLab (Newport News, Virginia) and FNAL (Batavia, Illinois). A transportation system has been designed and built to safely transport the CMs over the road. It uses an array of helical isolator springs to attenuate shocks on the CM to below 1.5g in all directions. The system rides on trailers equipped with Air-Ride suspension, which attenuates vibration loads. The prototype LCLS-II CM (pCM) was driven 750 miles to test the transport system; shock loggers recorded the shock attenuation on the pCM and vacuum gauges were used to detect any compromises in beamline vacuum. Alignment measurements were taken before and after the trip to check whether cavity positions had shifted beyond the ± 0.2mm spec. Passband frequencies and cavity gradients were measured at 2K at the Cryomodule Test Facility (CMTF) at JLab to identify any degradation of CM performance after transportation. The transport system was found to have safely carried the CM and is cleared to begin shipments from JLab and FNAL to SLAC.

  3. Stereospecific transport of Tyr-MIF-1 across the blood-brain barrier by peptide transport system-1

    Energy Technology Data Exchange (ETDEWEB)

    Banks, W.A.; Kastin, A.J.; Michals, E.A.; Barrera, C.M. (Veterans Affairs Medical Center, New Orleans, LA (USA))

    1990-10-01

    Previous studies have suggested that peptide transport system-1 (PTS-1), the saturable system that transports Tyr-MIF-1, the enkephalins, and related peptides out of the central nervous system (CNS), exhibits stereospecificity. In the present studies, we showed that {sup 125}I-L-Tyr-MIF-1, but not {sup 131}I-D-Tyr-MIF-1, was cleared from the CNS more rapidly than could be accounted for by nonspecific mechanisms. Such clearance was inhibited by a 1.0 nmol dose of L-Tyr-MIF-1, but not by D-Tyr-MIF-1. Neither L- nor D-Tyr-MIF-1 altered the much lower clearance of I-D-Tyr-MIF-1 from the brain. Radioactivity recovered from the vascular space after the injection of {sup 125}I-Tyr-MIF-1 into the lateral ventricle of the brain eluted by HPLC primarily as intact peptide, demonstrating that most of the Tyr-MIF-1 was not degraded during transport. By contrast, the nonsaturable unidirectional influx of Tyr-MIF-1 into the CNS did not distinguish between the isomers. These studies confirm and extend the observations that Tyr-MIF-1 is transported out of the CNS by a saturable, stereospecific transport system as an intact peptide while the influx into the CNS is by a nonsaturable mechanism that does not distinguish between the isomers.

  4. Role of Renin-Angiotensin system and oxidative stress on vascular inflammation in insulin resistence model.

    Science.gov (United States)

    Renna, N F; Lembo, C; Diez, E; Miatello, R M

    2013-01-01

    (1) This study aims to demonstrate the causal involvement of renin angiotensin system (RAS) and oxidative stress (OS) on vascular inflammation in an experimental model of metabolic syndrome (MS) achieved by fructose administration to spontaneously hypertensive rats (FFHR) during 12 weeks. (2) Chronic treatment with candesartan (C) (10 mg/kg per day for the last 6 weeks) or 4OH-Tempol (T) (10(-3) mmol/L in drinking water for the last 6 weeks) reversed the increment in metabolic variables and systolic blood pressure. In addition, chronic C treatment reverted cardiovascular remodeling but not T. (3) Furthermore, chronic treatment with C was able to completely reverse the expression of NF-κB and VCAM-1, but T only reduced the expression. C reduced the expression of proatherogenic cytokines as CINC2, CINC3, VEGF, Leptin, TNF-alpha, and MCP-1 and also significantly reduced MIP-3, beta-NGF, and INF-gamma in vascular tissue in this experimental model. T was not able to substantially modify the expression of these cytokines. (4) The data suggest the involvement of RAS in the expression of inflammatory proteins at different vascular levels, allowing the creation of a microenvironment suitable for the creation, perpetuation, growth, and destabilization of vascular injury.

  5. Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model

    Directory of Open Access Journals (Sweden)

    N. F. Renna

    2013-01-01

    Full Text Available (1 This study aims to demonstrate the causal involvement of renin angiotensin system (RAS and oxidative stress (OS on vascular inflammation in an experimental model of metabolic syndrome (MS achieved by fructose administration to spontaneously hypertensive rats (FFHR during 12 weeks. (2 Chronic treatment with candesartan (C (10 mg/kg per day for the last 6 weeks or 4OH-Tempol (T (10−3 mmol/L in drinking water for the last 6 weeks reversed the increment in metabolic variables and systolic blood pressure. In addition, chronic C treatment reverted cardiovascular remodeling but not T. (3 Furthermore, chronic treatment with C was able to completely reverse the expression of NF-κB and VCAM-1, but T only reduced the expression. C reduced the expression of proatherogenic cytokines as CINC2, CINC3, VEGF, Leptin, TNF-alpha, and MCP-1 and also significantly reduced MIP-3, beta-NGF, and INF-gamma in vascular tissue in this experimental model. T was not able to substantially modify the expression of these cytokines. (4 The data suggest the involvement of RAS in the expression of inflammatory proteins at different vascular levels, allowing the creation of a microenvironment suitable for the creation, perpetuation, growth, and destabilization of vascular injury.

  6. Transport modeling: An artificial immune system approach

    Directory of Open Access Journals (Sweden)

    Teodorović Dušan

    2006-01-01

    Full Text Available This paper describes an artificial immune system approach (AIS to modeling time-dependent (dynamic, real time transportation phenomenon characterized by uncertainty. The basic idea behind this research is to develop the Artificial Immune System, which generates a set of antibodies (decisions, control actions that altogether can successfully cover a wide range of potential situations. The proposed artificial immune system develops antibodies (the best control strategies for different antigens (different traffic "scenarios". This task is performed using some of the optimization or heuristics techniques. Then a set of antibodies is combined to create Artificial Immune System. The developed Artificial Immune transportation systems are able to generalize, adapt, and learn based on new knowledge and new information. Applications of the systems are considered for airline yield management, the stochastic vehicle routing, and real-time traffic control at the isolated intersection. The preliminary research results are very promising.

  7. 3D Monte Carlo model of optical transport in laser-irradiated cutaneous vascular malformations

    Science.gov (United States)

    Majaron, Boris; Milanič, Matija; Jia, Wangcun; Nelson, J. S.

    2010-11-01

    We have developed a three-dimensional Monte Carlo (MC) model of optical transport in skin and applied it to analysis of port wine stain treatment with sequential laser irradiation and intermittent cryogen spray cooling. Our MC model extends the approaches of the popular multi-layer model by Wang et al.1 to three dimensions, thus allowing treatment of skin inclusions with more complex geometries and arbitrary irradiation patterns. To overcome the obvious drawbacks of either "escape" or "mirror" boundary conditions at the lateral boundaries of the finely discretized volume of interest (VOI), photons exiting the VOI are propagated in laterally infinite tissue layers with appropriate optical properties, until they loose all their energy, escape into the air, or return to the VOI, but the energy deposition outside of the VOI is not computed and recorded. After discussing the selection of tissue parameters, we apply the model to analysis of blood photocoagulation and collateral thermal damage in treatment of port wine stain (PWS) lesions with sequential laser irradiation and intermittent cryogen spray cooling.

  8. The transport system for natural gas

    International Nuclear Information System (INIS)

    Bjoerndalen, Joergen; Nese, Gjermund

    2003-01-01

    In 2002, the actors on the Norwegian shelf in cooperation with the authorities established a new regime for sale and transport of gas. This article deals with some issues of interest relating to this new regime. The transport system for natural gas shows clear signs of being a natural monopoly, which makes it difficult to use the system efficiently. Two main problems of the current way of organizing are pointed out: (1) lack of price and market signals in capacity allocation and (2) unclear incentive effects. The article indicates a possible solution based on the form of organization that is used in the power market

  9. A demonstration of expert systems applications in transportation engineering : volume I, transportation engineers and expert systems.

    Science.gov (United States)

    1987-01-01

    Expert systems, a branch of artificial-intelligence studies, is introduced with a view to its relevance in transportation engineering. Knowledge engineering, the process of building expert systems or transferring knowledge from human experts to compu...

  10. Conflict simulation for surface transport systems

    International Nuclear Information System (INIS)

    Keeton, S.C.; De Laquil, P. III.

    1977-07-01

    An important element in the analysis of transportation safeguards systems is the determination of the outcome of an armed attack against the system. Such information is necessary to understand relationships among the various defender tactics, weapons systems, and adversary attributes. A battle model, SABRES, which can simulate safeguards engagements is under development. This paper briefly describes the first phase of SABRES and presents some examples of its capabilities

  11. Wireless Communications in Smart Rail Transportation Systems

    Directory of Open Access Journals (Sweden)

    César Briso-Rodríguez

    2017-01-01

    Full Text Available Railway, subway, airplane, and other transportation systems have drawn an increasing interest on the use of wireless communications for critical and noncritical services to improve performance, reliability, and passengers experience. Smart transportation systems require the use of critical communications for operation and control, and wideband services can be provided using noncritical communications. High speed train (HST is one of the best test cases for the analysis of communication links and specification of the general requirements for train control and supervision, passenger communications, and onboard and infrastructure wireless sensors. In this paper, we analyze in detail critical and noncritical networks mainly using the HST as a test case. First, the different types of links for smart rail transportation are described, specifying the main requirements of the transportation systems, communications, and their applications for different services. Then, we propose a network architecture and requirements of the communication technologies for critical and noncritical data. Finally, an analysis is made for the future technologies, including the fifth-generation (5G communications, millimeter wave (mmWave, terahertz (THz, and satellites for critical and high-capacity communications in transportation.

  12. Hemodynamic comparison of mild and severe preeclampsia: concept of stroke systemic vascular resistance index.

    Science.gov (United States)

    Scardo, J; Kiser, R; Dillon, A; Brost, B; Newman, R

    1996-01-01

    Our purpose was to compare baseline hemodynamic parameters of mild and severe preeclampsia. Patients admitted to the Medical University Labor and Delivery Unit with the diagnosis of preeclampsia who had not received prior antihypertensive or magnesium sulfate therapy were recruited for noninvasive hemodynamic monitoring with thoracic electrical bioimpedance. After stabilization in the lateral recumbent position, hemodynamic monitoring was begun. Baseline hemodynamic parameters, mean arterial pressure (MAP), heart rate (HR), systemic vascular resistance index (SVRI), cardiac index (CI), and stroke index (SI) were recorded. Stroke systemic vascular resistance index (SSVRI), the resistance imposed by vasculature on each beat of the heart, was calculated for each patient by multiplying SVRI by HR. For statistical analysis, unpaired Student's t-tests (two-tailed) were utilized (P preclampsia appears to be a more intensely vasoconstricted state than mild preeclampsia. Although CI is inversely proportional to SVRI, increased HR in severe preeclampsia prevents this expected decrease in cardiac output.

  13. Congenital anomalous/aberrant systemic artery to pulmonary venous fistula: Closure with vascular plugs & coil embolization

    Directory of Open Access Journals (Sweden)

    Pankaj Jariwala

    2014-01-01

    Full Text Available A 7-month-old girl with failure to thrive, who, on clinical and diagnostic evaluation [echocardiography & CT angiography] to rule out congenital heart disease, revealed a rare vascular anomaly called systemic artery to pulmonary venous fistula. In our case, there was dual abnormal supply to the entire left lung as1 anomalous supply by normal systemic artery [internal mammary artery]2 and an aberrant feeder vessel from the abdominal aorta. Left Lung had normal bronchial connections and normal pulmonary vasculature. The fistula drained through the pulmonary veins to the left atrium leading to ‘left–left shunt’. Percutaneous intervention in two stages was performed using Amplatzer vascular plugs and coil embolization to close them successfully. The patient gained significant weight in follow up with other normal developmental and mental milestones.

  14. Crew Transportation System Design Reference Missions

    Science.gov (United States)

    Mango, Edward J.

    2015-01-01

    Contains summaries of potential design reference mission goals for systems to transport humans to andfrom low Earth orbit (LEO) for the Commercial Crew Program. The purpose of this document is to describe Design Reference Missions (DRMs) representative of the end-to-end Crew Transportation System (CTS) framework envisioned to successfully execute commercial crew transportation to orbital destinations. The initial CTS architecture will likely be optimized to support NASA crew and NASA-sponsored crew rotation missions to the ISS, but consideration may be given in this design phase to allow for modifications in order to accomplish other commercial missions in the future. With the exception of NASA’s mission to the ISS, the remaining commercial DRMs are notional. Any decision to design or scar the CTS for these additional non-NASA missions is completely up to the Commercial Provider. As NASA’s mission needs evolve over time, this document will be periodically updated to reflect those needs.

  15. Simulations of magnetic capturing of drug carriers in the brain vascular system

    Energy Technology Data Exchange (ETDEWEB)

    Kenjeres, S., E-mail: S.Kenjeres@tudelft.nl [Department of Multi-Scale Physics, Faculty of Applied Sciences, J.M. Burgerscentre for Fluid Dynamics, Delft University of Technology, Leeghwaterstraat 39, 2628 CB Delft (Netherlands); Righolt, B.W. [Department of Multi-Scale Physics, Faculty of Applied Sciences, J.M. Burgerscentre for Fluid Dynamics, Delft University of Technology, Leeghwaterstraat 39, 2628 CB Delft (Netherlands)

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer Blood flow and magnetic particles distributions in the brain vascular system simulated. Black-Right-Pointing-Pointer Numerical mesh generated from raw MRI images. Black-Right-Pointing-Pointer Significant increase in local capturing of magnetic particles obtained. Black-Right-Pointing-Pointer Promising technique for localised non-invasive treatment of brain tumours. - Abstract: The present paper reports on numerical simulations of blood flow and magnetic drug carrier distributions in a complex brain vascular system. The blood is represented as a non-Newtonian fluid by the generalised power law. The Lagrangian tracking of the double-layer spherical particles is performed to estimate particle deposition under influence of imposed magnetic field gradients across arterial walls. Two situations are considered: neutral (magnetic field off) and active control (magnetic field on) case. The double-layer spherical particles that mimic a real medical drug are characterised by two characteristic diameters - the outer one and the inner one of the magnetic core. A numerical mesh of the brain vascular system consisting of multi-branching arteries is generated from raw MRI scan images of a patient. The blood is supplied through four main inlet arteries and the entire vascular system includes more than 30 outlets, which are modelled by Murray's law. The no-slip boundary condition is applied for velocity components along the smooth and rigid arterial walls. Numerical simulations revealed detailed insights into blood flow patterns, wall-shear-stress and local particle deposition efficiency along arterial walls. It is demonstrated that magnetically targeted drug delivery significantly increased the particle capturing efficiency in the pre-defined regions. This feature can be potentially useful for localised, non-invasive treatment of brain tumours.

  16. Developing intelligent transportation systems using the national ITS architecture: an executive edition for senior transportation managers

    Science.gov (United States)

    1998-02-01

    This document has been produced to provide senior transportation managers of state and local departments of transportation with practical guidance for deploying Intelligent Transportation Systems (ITS) consistent with the National ITS Architecture. T...

  17. The Meanings and Prospects of Primo Vascular System from the Viewpoint of Historical Context

    Directory of Open Access Journals (Sweden)

    Jongwook Jeon

    2013-01-01

    Full Text Available The aim of this overview is to evaluate the primo vascular system research in the context of the history of meridian theory and the modern meanings of it. The 12 meridian systems were naturally presupposed in the conventional study of the meridians and acupuncture. But the excavations of Mawang-tui old documents and Sichuan Mianyang wooden puppet revealed the primordial concepts of meridians uncolored by the numerological cosmology of Han era. Further, the meridian map of horse, cow and hawk show another resemblance to the primordial type of meridians. Modern meridian theory has been challenged by the material based scientific theory and the primo vascular theory presents the most radical answer for it. It aims to reveal the anatomical entity of meridians. However, the study of primo vascular system is unexpectedly opening the new horizon of scientific integration of East and West beyond the mere searching for anatomical entity of meridians. Conclusions we have drawn from the historical reviews are, (1 the surface structure of the body reflects the physiopathological changes of inside the body, (2 by stimulating specific sites on the surface, it is possible to acquire therapeutic effects of certain symptoms, and (3 numbers and locations of meridian acupoints are variable among traditional meridian theories.

  18. Differential privacy in intelligent transportation systems

    NARCIS (Netherlands)

    Kargl, Frank; Friedman, Arik; Boreli, Roksana

    2013-01-01

    In this paper, we investigate how the concept of differential privacy can be applied to Intelligent Transportation Systems (ITS), focusing on protection of Floating Car Data (FCD) stored and processed in central Traffic Data Centers (TDC). We illustrate an integration of differential privacy with

  19. The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems

    Science.gov (United States)

    Wu, Min; Frieboes, Hermann B.; McDougall, Steven R.; Chaplain, Mark A.J.; Cristini, Vittorio; Lowengrub, John

    2013-01-01

    distribution of oxygen, solid tumor pressure and a broad-based collapse of the tumor lymphatics. We also find that the rate that IFF is fluxed into the lymphatics and host tissue is largely controlled by an elevated vascular hydraulic conductivity in the tumor. We discuss the implications of these results on microenvironmental transport barriers, and the tumor invasive and metastatic potential. Our results suggest the possibility of developing strategies of targeting tumor cells based on the cues in the interstitial fluid. PMID:23220211

  20. Complex Nonlinear Autonomic Nervous System Modulation Link Cardiac Autonomic Neuropathy and Peripheral Vascular Disease

    Directory of Open Access Journals (Sweden)

    Kinda eKhalaf

    2015-03-01

    Full Text Available Background: Physiological interactions are abundant within, and between, body systems. These interactions may evolve into discrete states during pathophysiological processes resulting from common mechanisms. An association between arterial stenosis, identified by low ankle-brachial pressure index (ABPI and cardiovascular disease (CVD as been reported. Whether an association between vascular calcification - characterized by high ABPI and a different pathophysiology - is similarly associated with CVD, has not been established. The current study aims to investigate the association between ABPI, and cardiac rhythm, as an indicator of cardiovascular health and functionality, utilising heart rate variability (HRV.Methods and Results: Two hundred and thirty six patients underwent ABPI assessment. Standard time and frequency domain, and non-linear HRV measures were determined from 5-minute electrocardiogram. ABPI data were divided into normal (n=101, low (n=67 and high (n=66 and compared to HRV measures.(DFAα1 and SampEn were significantly different between the low ABPI, high ABPI and control groups (p<0.05.Conclusion: A possible coupling between arterial stenosis and vascular calcification with decreased and increased HRV respectively was observed. Our results suggest a model for interpreting the relationship between vascular pathophysiology and cardiac rhythm. The cardiovascular system may be viewed as a complex system comprising a number of interacting subsystems. These cardiac and vascular subsystems/networks may be coupled and undergo transitions in response to internal or external perturbations. From a clinical perspective, the significantly increased sample entropy compared to the normal ABPI group and the decreased and increased complex correlation properties measured by DFA for the low and high ABPI groups respectively, may be useful indicators that a more holistic treatment approach in line with this more complex clinical picture is required.

  1. Advanced technologies for intelligent transportation systems

    CERN Document Server

    Picone, Marco; Amoretti, Michele; Zanichelli, Francesco; Ferrari, Gianluigi

    2015-01-01

    This book focuses on emerging technologies in the field of Intelligent Transportation Systems (ITSs) namely efficient information dissemination between vehicles, infrastructures, pedestrians and public transportation systems. It covers the state-of-the-art of Vehicular Ad-hoc Networks (VANETs), with centralized and decentralized (Peer-to-Peer) communication architectures, considering several application scenarios. With a detailed treatment of emerging communication paradigms, including cross networking  and distributed algorithms. Unlike most of the existing books, this book presents a multi-layer overview of information dissemination systems, from lower layers (MAC) to high layers (applications). All those aspects are investigated considering the use of mobile devices, such as smartphones/tablets and embedded systems, i.e. technologies that during last years completely changed the current market, the user expectations, and communication networks. The presented networking paradigms are supported and validate...

  2. Application of vascular aquatic plants for pollution removal, energy and food production in a biological system

    Science.gov (United States)

    Wolverton, B. C.; Barlow, R. M.; Mcdonald, R. C.

    1975-01-01

    Vascular aquatic plants such as water hyacinths (Eichhornia crassipes) (Mart.) Solms and alligator weeds (Alternanthera philoxeroides) (Mart.) Griesb., when utilized in a controlled biological system (including a regular program of harvesting to achieve maximum growth and pollution removal efficiency), may represent a remarkably efficient and inexpensive filtration and disposal system for toxic materials and sewage released into waters near urban and industrial areas. The harvested and processed plant materials are sources of energy, fertilizer, animal feed, and human food. Such a system has industrial, municipal, and agricultural applications.

  3. Simulating charge transport in flexible systems

    Directory of Open Access Journals (Sweden)

    Timothy Clark

    2015-12-01

    Full Text Available Systems in which movements occur on two significantly different time domains, such as organic electronic components with flexible molecules, require different simulation techniques for the two time scales. In the case of molecular electronics, charge transport is complicated by the several different mechanisms (and theoretical models that apply in different cases. We cannot yet combine time scales of molecular and electronic movement in simulations of real systems. This review describes our progress towards this goal.

  4. Study of the Operational Safety of a Vascular Interventional Surgical Robotic System

    Directory of Open Access Journals (Sweden)

    Jian Guo

    2018-03-01

    Full Text Available This paper proposes an operation safety early warning system based on LabView (2014, National Instruments Corporation, Austin, TX, USA for vascular interventional surgery (VIS robotic system. The system not only provides intuitive visual feedback information for the surgeon, but also has a safety early warning function. It is well known that blood vessels differ in their ability to withstand stress in different age groups, therefore, the operation safety early warning system based on LabView has a vascular safety threshold function that changes in real-time, which can be oriented to different age groups of patients and a broader applicable scope. In addition, the tracing performance of the slave manipulator to the master manipulator is also an important index for operation safety. Therefore, we also transformed the slave manipulator and integrated the displacement error compensation algorithm in order to improve the tracking ability of the slave manipulator to the master manipulator and reduce master–slave tracking errors. We performed experiments “in vitro” to validate the proposed system. According to previous studies, 0.12 N is the maximum force when the blood vessel wall has been penetrated. Experimental results showed that the proposed operation safety early warning system based on LabView combined with operating force feedback can effectively avoid excessive collisions between the surgical catheter and vessel wall to avoid vascular puncture. The force feedback error of the proposed system is maintained between ±20 mN, which is within the allowable safety range and meets our design requirements. Therefore, the proposed system can ensure the safety of surgery.

  5. The behavior of the vascular system in the experimental tumor radiotherapy

    International Nuclear Information System (INIS)

    Yamaura, Hirotsugu; Matsuzawa, Taiju; Sato, Haruo; Ito, Yasuhiko.

    1975-01-01

    The rat ascites hepatoma AH109A transplanted and grown in the rat transparent chamber developed a tumor specific vascular system, the process of which was quantitatively studied because of the vascular length, surface area, and volume per mm 3 of tissue. The values changed characteristically in each stage of the course. The tumor was irradiated in a chamber with 3000 R of 60 Co γ-rays, and the tumor cells died leaving behind highly dense capillary networks, which gradually returned to normal level by 7 days after irradiation. The blood vessels, either preformed or newly formed, in the control tissue without tumor were not damaged by this dose. But the proliferation of capillary buds were inhibited slightly with 400 R and completely with 4000 R. (auth.)

  6. The behavior of the vascular system in the experimental tumor radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Yamaura, H; Matsuzawa, T; Sato, H [Tohoku Univ., Sendai (Japan). Research Inst. for Tuberculosis, Leprosy and Cancer; Ito, Yasuhiko

    1975-07-01

    The rat ascites hepatoma AH109A transplanted and grown in the rat transparent chamber developed a tumor specific vascular system, the process of which was quantitatively studied because of the vascular length, surface area, and volume per mm/sup 3/ of tissue. The values changed characteristically in each stage of the course. The tumor was irradiated in a chamber with 3000 R of /sup 60/Co ..gamma..-rays, and the tumor cells died leaving behind highly dense capillary networks, which gradually returned to normal level by 7 days after irradiation. The blood vessels, either preformed or newly formed, in the control tissue without tumor were not damaged by this dose. But the proliferation of capillary buds were inhibited slightly with 400 R and completely with 4000 R.

  7. IOT Based Smart Public Transport System

    Directory of Open Access Journals (Sweden)

    Parag Gawade

    2017-07-01

    Full Text Available Internet of Things IoT joins the objects of this present reality to the virtual world and empowers at whatever time anyplace network for anything that has a turn ON and turn OFF switch. It constitutes to a world where physical things and humans and other living things and virtual information and situations collaborate with each other. Substantial measure of information is created as expansive number of gadgets is associated with the web. So this expansive measure of information must be controlled and changed over to helpful data keeping in mind the end goal to create productive frameworks. In this paper we concentrate on to a urban IoT framework that is utilized to construct Intelligent Transportation System ITS. IoT based intelligent transportation systems are intended to bolster the Smart City vision which intends to utilize the progressed and capable communication systems for the organization of the city and the residents.

  8. Automatic braking system modification for the Advanced Transport Operating Systems (ATOPS) Transportation Systems Research Vehicle (TSRV)

    Science.gov (United States)

    Coogan, J. J.

    1986-01-01

    Modifications were designed for the B-737-100 Research Aircraft autobrake system hardware of the Advanced Transport Operating Systems (ATOPS) Program at Langley Research Center. These modifications will allow the on-board flight control computer to control the aircraft deceleration after landing to a continuously variable level for the purpose of executing automatic high speed turn-offs from the runway. A bread board version of the proposed modifications was built and tested in simulated stopping conditions. Test results, for various aircraft weights, turnoff speed, winds, and runway conditions show that the turnoff speeds are achieved generally with errors less than 1 ft/sec.

  9. Guide to federal intelligent transportation system (ITS) research.

    Science.gov (United States)

    2013-01-01

    The U.S. Department of Transportations (USDOT) Intelligent Transportation System (ITS) Program aims to bring connectivity to transportation through the use of advanced wireless technologies powerful technologies that enable transformative chan...

  10. Operational Efficiency of Public Transport System in Kwara State ...

    African Journals Online (AJOL)

    Operational Efficiency of Public Transport System in Kwara State, Nigeria. ... The paper examines the operations of Public Transport in Nigeria using the Kwara State Transport Service as a case study. ... EMAIL FULL TEXT EMAIL FULL TEXT

  11. Stochastic transport processes in discrete biological systems

    CERN Document Server

    Frehland, Eckart

    1982-01-01

    These notes are in part based on a course for advanced students in the applications of stochastic processes held in 1978 at the University of Konstanz. These notes contain the results of re­ cent studies on the stochastic description of ion transport through biological membranes. In particular, they serve as an introduction to an unified theory of fluctuations in complex biological transport systems. We emphasize that the subject of this volume is not to introduce the mathematics of stochastic processes but to present a field of theoretical biophysics in which stochastic methods are important. In the last years the study of membrane noise has become an important method in biophysics. Valuable information on the ion transport mechanisms in membranes can be obtained from noise analysis. A number of different processes such as the opening and closing of ion channels have been shown to be sources of the measured current or voltage fluctuations. Bio­ logical 'transport systems can be complex. For example, the tr...

  12. An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback.

    Science.gov (United States)

    Chang, Yen-Chi; Berry-Pusey, Brittany; Yasin, Rashid; Vu, Nam; Maraglia, Brandon; Chatziioannou, Arion X; Tsao, Tsu-Chin

    2015-08-01

    This paper develops an automated vascular access system (A-VAS) with novel vision-based vein and needle detection methods and real-time pressure feedback for murine drug delivery. Mouse tail vein injection is a routine but critical step for preclinical imaging applications. Due to the small vein diameter and external disturbances such as tail hair, pigmentation, and scales, identifying vein location is difficult and manual injections usually result in poor repeatability. To improve the injection accuracy, consistency, safety, and processing time, A-VAS was developed to overcome difficulties in vein detection noise rejection, robustness in needle tracking, and visual servoing integration with the mechatronics system.

  13. Road Transportable Analytical Laboratory (RTAL) system

    International Nuclear Information System (INIS)

    1993-01-01

    The goal of this contractual effort is the development and demonstration of a Road Transportable Analytical Laboratory (RTAL) system to meet the unique needs of the Department of Energy (DOE) for rapid, accurate analysis of a wide variety of hazardous and radioactive contaminants in soil, groundwater, and surface waters. This laboratory system will be designed to provide the field and laboratory analytical equipment necessary to detect and quantify radionuclides, organics, heavy metals and other inorganics, and explosive materials. The planned laboratory system will consist of a set of individual laboratory modules deployable independently or as an interconnected group to meet each DOE site's specific needs

  14. Contact area affects frequency-dependent responses to vibration in the peripheral vascular and sensorineural systems.

    Science.gov (United States)

    Krajnak, Kristine; Miller, G R; Waugh, Stacey

    2018-01-01

    Repetitive exposure to hand-transmitted vibration is associated with development of peripheral vascular and sensorineural dysfunctions. These disorders and symptoms associated with it are referred to as hand-arm vibration syndrome (HAVS). Although the symptoms of the disorder have been well characterized, the etiology and contribution of various exposure factors to development of the dysfunctions are not well understood. Previous studies performed using a rat-tail model of vibration demonstrated that vascular and peripheral nervous system adverse effects of vibration are frequency-dependent, with vibration frequencies at or near the resonant frequency producing the most severe injury. However, in these investigations, the amplitude of the exposed tissue was greater than amplitude typically noted in human fingers. To determine how contact with vibrating source and amplitude of the biodynamic response of the tissue affects the risk of injury occurring, this study compared the influence of frequency using different levels of restraint to assess how maintaining contact of the tail with vibrating source affects the transmission of vibration. Data demonstrated that for the most part, increasing the contact of the tail with the platform by restraining it with additional straps resulted in an enhancement in transmission of vibration signal and elevation in factors associated with vascular and peripheral nerve injury. In addition, there were also frequency-dependent effects, with exposure at 250 Hz generating greater effects than vibration at 62.5 Hz. These observations are consistent with studies in humans demonstrating that greater contact and exposure to frequencies near the resonant frequency pose the highest risk for generating peripheral vascular and sensorineural dysfunction.

  15. Arterial intelligent transportation systems : infrastructure elements and traveler information requirements.

    Science.gov (United States)

    2009-08-01

    Applying Intelligent Transportation Systems (ITS) to arterial systems allows TxDOT to significantly enhance : transportation system operation efficiency and improve traffic mobility. However, no guidelines are available to : assist TxDOT staff in sel...

  16. Low energy beam transport system developments

    Energy Technology Data Exchange (ETDEWEB)

    Dudnikov, V., E-mail: vadim@muonsinc.com [Muons, Inc., Batavia, IL 60510 (United States); Han, B.; Stockli, M.; Welton, R. [ORNL, Oak Ridge, TN 37831 (United States); Dudnikova, G. [University of Maryland, College Park, MD 3261 (United States); Institute of Computational Technologies SBRAS, Novosibirsk (Russian Federation)

    2015-04-08

    For high brightness beam production it is important to preserve the brightness in the low energy beam transport system (LEBT) used to transport and match the ion beams to the next stage of acceleration, usually an RFQ. While electrostatic focusing can be problematic for high current beam transport, reliable electrostatic LEBT operation has been demonstrated with H{sup −} beams up to 60 mA. Now, however, it is commonly accepted that an optimal LEBT for high current accelerator applications consists of focusing solenoids with space charge compensation. Two-solenoid LEBTs are successfully used for high current (>100 mA) proton beam transport. Preservation of low emittances (~0.15 π mm-mrad) requires the addition of a heavy gas (Xe, Kr), which causes ~5% of proton loss in a 1 m long LEBT. Similar Xe densities would be required to preserve low emittances of H{sup −} beams, but such gas densities cause unacceptably high H{sup −} beam losses. A short LEBT with only one short solenoid, movable for RFQ matching, can be used for reduced negative ion stripping. A strong electrostatic-focusing LEBT has been successfully adopted for transport of high current H{sup −} beams in the SNS Front End. Some modifications of such electrostatic LEBTs are expected to improve the reliable transport of intense positive and negative ion beams without greatly degrading their low emittances. We concentrate on processes that determine the beam brightness degradation and on their prevention. Proposed improvements to the SNS electrostatic LEBT are discussed.

  17. Vascular lumen formation.

    Science.gov (United States)

    Lammert, Eckhard; Axnick, Jennifer

    2012-04-01

    The vascular system developed early in evolution. It is required in large multicellular organisms for the transport of nutrients, oxygen, and waste products to and from tissues. The vascular system is composed of hollow tubes, which have a high level of complexity in vertebrates. Vasculogenesis describes the de novo formation of blood vessels, e.g., aorta formation in vertebrate embryogenesis. In contrast, angiogenesis is the formation of blood vessels from preexisting ones, e.g., sprouting of intersomitic blood vessels from the aorta. Importantly, the lumen of all blood vessels in vertebrates is lined and formed by endothelial cells. In both vasculogenesis and angiogenesis, lumen formation takes place in a cord of endothelial cells. It involves a complex molecular mechanism composed of endothelial cell repulsion at the cell-cell contacts within the endothelial cell cords, junctional rearrangement, and endothelial cell shape change. As the vascular system also participates in the course of many diseases, such as cancer, stroke, and myocardial infarction, it is important to understand and make use of the molecular mechanisms of blood vessel formation to better understand and manipulate the pathomechanisms involved.

  18. Fuels processing for transportation fuel cell systems

    Science.gov (United States)

    Kumar, R.; Ahmed, S.

    Fuel cells primarily use hydrogen as the fuel. This hydrogen must be produced from other fuels such as natural gas or methanol. The fuel processor requirements are affected by the fuel to be converted, the type of fuel cell to be supplied, and the fuel cell application. The conventional fuel processing technology has been reexamined to determine how it must be adapted for use in demanding applications such as transportation. The two major fuel conversion processes are steam reforming and partial oxidation reforming. The former is established practice for stationary applications; the latter offers certain advantages for mobile systems and is presently in various stages of development. This paper discusses these fuel processing technologies and the more recent developments for fuel cell systems used in transportation. The need for new materials in fuels processing, particularly in the area of reforming catalysis and hydrogen purification, is discussed.

  19. The Efficiency of the Bimodal System Transportation

    Directory of Open Access Journals (Sweden)

    Nada Štrumberger

    2012-10-01

    Full Text Available The development of fast railway results in an increased applicationof Trailer Train bimodal system transportation. Thetraffic costs are multiply reduced, particularly the variablecosts. On the other hand the environmental pollution from exhaustgases is also reduced. Therefore, by the year 2010 cargotransport should be preponderant~v used which would be characterisedby fast electric trains producing less noise, at lowercosts and with clean environment.

  20. Cotton Transportation and Logistics: A Dynamic System

    OpenAIRE

    Robinson, John R.; Park, John L.; Fuller, Stephen

    2007-01-01

    The paper reviews the evolution of U.S. cotton transportation and logistics patterns over the last three decades. There have been many forces of change over this time period, with the largest change being a shift from primarily domestic market destinations to the international market. We describe the pre-1999 system and flow patterns when domestic consumption of U.S. cotton was dominant. We contrast this with current flow patterns as measured by available secondary export data and a sample of...

  1. Assateague Island National Seashore alternative transportation systems planning study and business plan for alternative transportation

    Science.gov (United States)

    2012-08-31

    The purpose of this study was to (1) study the potential expansion of existing alternative transportation systems (bicycle facilities) and development of new alternative transportation systems in and around the Maryland District of Assateague Island ...

  2. An early validation of the Society for Vascular Surgery lower extremity threatened limb classification system.

    Science.gov (United States)

    Cull, David L; Manos, Ginger; Hartley, Michael C; Taylor, Spence M; Langan, Eugene M; Eidt, John F; Johnson, Brent L

    2014-12-01

    The Society for Vascular Surgery (SVS) recently established the Lower Extremity Threatened Limb Classification System, a staging system using Wound characteristic, Ischemia, and foot Infection (WIfI) to stratify the risk for limb amputation at 1 year. Although intuitive in nature, this new system has not been validated. The purpose of the following study was to determine whether the WIfI system is predictive of limb amputation and wound healing. Between 2007 and 2010, we prospectively obtained data related to wound characteristics, extent of infection, and degree of postrevascularization ischemia in 139 patients with foot wounds who presented for lower extremity revascularization (158 revascularization procedures). After adapting those data to the WIfI classifications, we analyzed the influence of wound characteristics, extent of infection, and degree of ischemia on time to wound healing; empirical Kaplan-Meier survival curves were compared with theoretical outcomes predicted by WIfI expert consensus opinion. Of the 158 foot wounds, 125 (79%) healed. The median time to wound healing was 2.7 months (range, 1-18 months). Factors associated with wound healing included presence of diabetes mellitus (P = .013), wound location (P = .049), wound size (P = .007), wound depth (P = .004), and degree of ischemia (P valid. Further validation of the WIfI classification system with multicenter data is justified. Copyright © 2014 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

  3. Evaluation of alternative public transportation systems in Izmit urban transportation via axiomatic design method

    Directory of Open Access Journals (Sweden)

    Gülşen AKMAN

    2016-02-01

    Full Text Available In the world and in our country, most of urban transportation is performed by public transportation. Public transportation is a system which provides transportation easiness and opportunity to people, not to vehicles. Therefore, giving priority to public transportation system is necessary in organizing urban transportation. In this study, in order to reduce traffic intensity and to facilitate passenger transportation in Izmit urban transportation, It is tried to determine appropriate public transportation system. For this, firstly, alternatives which could be used for public transportation were determined. These alternatives are metro, metrobus, tram, light rail system and monorail. Afterwards, the variables affecting decision making about public transportation were determined. These variables are cost, transportation line features, vehicle characteristics, sensitivity to environment and customer satisfaction. Lastly, most appropriate public transportation system is proposed by using the axiomatic design method. As a result, light trail system and metrobus are determined as the most appropriate alternatives for Izmit public transportation system.Keywords: Urban transportation, Multi criteria decision making, Axiomatic design

  4. The Palm Desert renewable [hydrogen] transportation system

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlin, C.E.; Lehman, P. [Humboldt State Univ., Arcata, CA (United States). Schatz Energy Research Center

    1998-08-01

    This paper describes the Schatz Energy Research Center (SERC) progress on the Palm Desert Renewable Hydrogen Transportation System Project for the period June 1997 through May 1998. The project began in March 1996. The goal of the Palm Desert Project is to develop a clean and sustainable transportation system for a community. The project demonstrates the practical utility of hydrogen as a transportation fuel and the proton exchange membrane (PEM) fuel cell as a vehicle power system. The project includes designing and building 4 fuel cell powered vehicles, a solar hydrogen generating and refueling station, and a fuel cell vehicle diagnostic center. Over this last year, SERC has built a fuel cell powered neighborhood electric vehicle and delivered it to the City of Palm Desert. The design of the hydrogen refueling station is near completion and it is anticipated that construction will be complete in the fall of 1998. The vehicles are currently being refueled at a temporary refueling station. The diagnostic center is being designed and maintenance procedures as well as computer diagnostic programs for the fuel cell vehicles are being developed. City employees are driving the vehicles daily and monitoring data are being collected. The drivers are pleased with the performance of the vehicles.

  5. Pipesworld : applying planning systems to pipeline transportation

    Energy Technology Data Exchange (ETDEWEB)

    Milidiu, R.L.; Santos Liporace, F. [Pontificia Univ. Catolica, Rio de Janeiro (Brazil). Dept. de Informatica

    2004-07-01

    This paper explored issues facing the complex task of managing pipelines that transport large volumes of petroleum products over long distances. Since oil pipelines are generally a few inches wide and several miles long, reasonable amounts of distinct products can be transported with very small loss due to the mixing at liquid boundaries. Optimizing the transportation through oil pipelines in terms of maintenance and environmental safety is a high priority for pipeline operators. This paper presented the Pipesworld model which takes into account features such as product interface constraints, limited product storage capacities and due dates for product delivery. It has been benchmarked as a start-of-art general purpose artificial planning system. This paper also reported the results derived by general purpose artificial intelligence planning systems when applied to the Pipesworld model. It demonstrated how various modelling techniques can be used to enhance the planners performance. Current work in developing Plumber was also presented. This dedicated solver that addresses operational situations uses both general purpose planning techniques as well as domain specific knowledge. When Plumber was incorporated into Pipesworld, its outperformed Fast-Forward, one of the best available general purpose planning systems, suggesting that improved versions of Plumber have the potential to deal with various problem scenarios in pipeline operations. 11 refs., 2 tabs., 3 figs.

  6. The Place of Railway Transport in Romania’s Transport System

    OpenAIRE

    Dãneci-Pãtrãu Daniel; Coca Carmen Elena

    2012-01-01

    The transport activity in all its forms represents one of the most complex sections of an economy, but also an important factor of influence over the quality of life, that is why current preoccupations of international organisms are oriented towards measures meant to develop performing transport systems and compatible with the environment. In the article the main activities and resources of Romania’s railway transport system are presented , the place of the railway transport in the transport ...

  7. Visualizing Mobility of Public Transportation System.

    Science.gov (United States)

    Zeng, Wei; Fu, Chi-Wing; Arisona, Stefan Müller; Erath, Alexander; Qu, Huamin

    2014-12-01

    Public transportation systems (PTSs) play an important role in modern cities, providing shared/massive transportation services that are essential for the general public. However, due to their increasing complexity, designing effective methods to visualize and explore PTS is highly challenging. Most existing techniques employ network visualization methods and focus on showing the network topology across stops while ignoring various mobility-related factors such as riding time, transfer time, waiting time, and round-the-clock patterns. This work aims to visualize and explore passenger mobility in a PTS with a family of analytical tasks based on inputs from transportation researchers. After exploring different design alternatives, we come up with an integrated solution with three visualization modules: isochrone map view for geographical information, isotime flow map view for effective temporal information comparison and manipulation, and OD-pair journey view for detailed visual analysis of mobility factors along routes between specific origin-destination pairs. The isotime flow map linearizes a flow map into a parallel isoline representation, maximizing the visualization of mobility information along the horizontal time axis while presenting clear and smooth pathways from origin to destinations. Moreover, we devise several interactive visual query methods for users to easily explore the dynamics of PTS mobility over space and time. Lastly, we also construct a PTS mobility model from millions of real passenger trajectories, and evaluate our visualization techniques with assorted case studies with the transportation researchers.

  8. Convergent evolution of vascular optimization in kelp (Laminariales).

    Science.gov (United States)

    Drobnitch, Sarah Tepler; Jensen, Kaare H; Prentice, Paige; Pittermann, Jarmila

    2015-10-07

    Terrestrial plants and mammals, although separated by a great evolutionary distance, have each arrived at a highly conserved body plan in which universal allometric scaling relationships govern the anatomy of vascular networks and key functional metabolic traits. The universality of allometric scaling suggests that these phyla have each evolved an 'optimal' transport strategy that has been overwhelmingly adopted by extant species. To truly evaluate the dominance and universality of vascular optimization, however, it is critical to examine other, lesser-known, vascularized phyla. The brown algae (Phaeophyceae) are one such group--as distantly related to plants as mammals, they have convergently evolved a plant-like body plan and a specialized phloem-like transport network. To evaluate possible scaling and optimization in the kelp vascular system, we developed a model of optimized transport anatomy and tested it with measurements of the giant kelp, Macrocystis pyrifera, which is among the largest and most successful of macroalgae. We also evaluated three classical allometric relationships pertaining to plant vascular tissues with a diverse sampling of kelp species. Macrocystis pyrifera displays strong scaling relationships between all tested vascular parameters and agrees with our model; other species within the Laminariales display weak or inconsistent vascular allometries. The lack of universal scaling in the kelps and the presence of optimized transport anatomy in M. pyrifera raises important questions about the evolution of optimization and the possible competitive advantage conferred by optimized vascular systems to multicellular phyla. © 2015 The Author(s).

  9. Development of cask and transportation system

    International Nuclear Information System (INIS)

    Ro, Seong Gy; Kang, Hee Dong; Lee, Heung Young; Seo, Ki Suk; Koo, Jung Hoe; Jung, Sung Hwan; Yoon, Jung Hyun; Lee, Ju Chan; Bang, Kyung Sik; Baek, Chang Yeol

    1992-03-01

    The major goal of this project is to establish the safe transport system and obtain the necessary data for cask development by during research work for the design and safety test of shipping cask. The analysis technique using computer code for design has been studied in the field of structure, thermal and shielding analysis in this study. And also the test and measurement technology was developed for the measuring system of drop and fire test. It is expected that research activity ensured in this job will enable us to ultilize the basic data for the cask development. (Author)

  10. The role of robotic surgical system in the management of vascular disease.

    Science.gov (United States)

    Lin, Judith C

    2013-10-01

    The evolution of minimally invasive treatment for aneurysms and occlusive disease has led to the development of endovascular, laparoscopic, and robot-assisted techniques. This article reviews the current literature on the clinical use of robotic surgical systems in the treatment of patients with aneurysms and occlusive disease. A MEDLINE search was performed using the keywords "robotic, vascular, AND surgery." All pertinent articles concerning the use of the robotic surgical system on aneurysms and occlusive disease were reviewed. The author's personal experience consisted of a retrospective review of a prospectively maintained confidential database on all procedures performed with the da Vinci(®) surgical system. Several robot-assisted laparoscopic series on the treatment of aortic disease were identified, including review articles of potential clinical applications in hybrid, laparoscopic vascular, and endovascular treatments for vascular patients using robotic technology. The use of computer-enhanced or robotic technology as a sole modality for bypass of occlusive disease and repair of abdominal aortic, splenic, and renal aneurysms was described in case series with satisfactory patient outcomes. Current robotic endovascular technology was also described. Minimally invasive techniques using endovascular, laparoscopic, or robot-assisted technology have revolutionized the treatment of aortoiliac, splanchnic, and renal aneurysms and occlusive disease. However, robot-assisted techniques for aortic disease may involve a learning curve and increased operating times. Although endovascular therapy is preferred because of faster recovery, this preference for improved short-term outcomes will be balanced with the superiority and durability of robot-assisted endoscopic methods as comparable to open surgery. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. FFTF Heat Transport System (HTS) component and system design

    International Nuclear Information System (INIS)

    Young, M.W.; Edwards, P.A.

    1980-01-01

    The FFTF Heat Transport Systems and Components designs have been completed and successfully tested at isothermal conditions up to 427 0 C (800 0 F). General performance has been as predicted in the design analyses. Operational flexibility and reliability have been outstanding throughout the test program. The components and systems have been demonstrated ready to support reactor powered operation testing planned later in 1980

  12. Role of Renin-Angiotensin System and Oxidative Stress on Vascular Inflammation in Insulin Resistence Model

    OpenAIRE

    Renna, N. F.; Lembo, C.; Diez, E.; Miatello, R. M.

    2013-01-01

    (1) is study aims to demonstrate the causal involvement of renin angiotensin system (RAS) and oxidative stress (OS) on vascular inammation in an experimental model of metabolic syndrome (MS) achieved by fructose administration to spontaneously hypertensive rats (FFHR) during 12 weeks. (2) Chronic treatment with candesartan (C) (10 mg/kg per day for the last 6 weeks) or 4OH-Tempol (T) (10−3 mmol/L in drinking water for the last 6 weeks) reversed the increment in metabolic variables and systo...

  13. Experience with new retrieval forceps for foreign body removal in the vascular and urinary systems

    International Nuclear Information System (INIS)

    Selby, J.B.; Bittner, G.M.; Tegtmeyer, C.J.

    1989-01-01

    A new type of forceps for foreign-body retrieval has recently become available. It consists of single- or multiple-toothed forceps mounted on a flexible, stainless steel shaft. The authors have used this device successfully three times in the vascular system and seven times in the urinary tract without complications. Foreign bodies removed include a catheter fragment, angiographic guidewire, detachable balloon, stone basket, and various ureteral stents. All the procedures were performed quickly and without difficulty. These forceps have become the authors' first choice in many retrieval situations

  14. Both acute and prolonged administration of EPO reduce cerebral and systemic vascular conductance in humans

    DEFF Research Database (Denmark)

    Rasmussen, Peter; Kim, Yu-Sok; Krogh-Madsen, Rikke

    2012-01-01

    Administration of erythropoietin (EPO) has been linked to cerebrovascular events. EPO reduces vascular conductance, possibly because of the increase in hematocrit. Whether EPO in itself affects the vasculature remains unknown; here it was evaluated in healthy males by determining systemic...... and cerebrovascular variables following acute (30,000 IU/d for 3 d; n=8) and chronic (5000 IU/week for 13 wk; n=8) administration of EPO, while the responsiveness of the vasculature was challenged during cycling exercise, with and without hypoxia. Prolonged administration of EPO increased hematocrit from 42.5 ± 3...

  15. Heavy particle transport in sputtering systems

    Science.gov (United States)

    Trieschmann, Jan

    2015-09-01

    This contribution aims to discuss the theoretical background of heavy particle transport in plasma sputtering systems such as direct current magnetron sputtering (dcMS), high power impulse magnetron sputtering (HiPIMS), or multi frequency capacitively coupled plasmas (MFCCP). Due to inherently low process pressures below one Pa only kinetic simulation models are suitable. In this work a model appropriate for the description of the transport of film forming particles sputtered of a target material has been devised within the frame of the OpenFOAM software (specifically dsmcFoam). The three dimensional model comprises of ejection of sputtered particles into the reactor chamber, their collisional transport through the volume, as well as deposition of the latter onto the surrounding surfaces (i.e. substrates, walls). An angular dependent Thompson energy distribution fitted to results from Monte-Carlo simulations is assumed initially. Binary collisions are treated via the M1 collision model, a modified variable hard sphere (VHS) model. The dynamics of sputtered and background gas species can be resolved self-consistently following the direct simulation Monte-Carlo (DSMC) approach or, whenever possible, simplified based on the test particle method (TPM) with the assumption of a constant, non-stationary background at a given temperature. At the example of an MFCCP research reactor the transport of sputtered aluminum is specifically discussed. For the peculiar configuration and under typical process conditions with argon as process gas the transport of aluminum sputtered of a circular target is shown to be governed by a one dimensional interaction of the imposed and backscattered particle fluxes. The results are analyzed and discussed on the basis of the obtained velocity distribution functions (VDF). This work is supported by the German Research Foundation (DFG) in the frame of the Collaborative Research Centre TRR 87.

  16. The vacuum-assisted closure (V.A.C®) system for surgical site infection with involved vascular grafts.

    Science.gov (United States)

    Saziye, Karaca; Afksendiyos, Kalangos

    2015-04-01

    In vascular surgery, surgical site infection is the most common postoperative morbidity, occurring in 5-10% of vascular patients. The optimal management of surgical site infection with involved lower limb vascular grafts remains controversial. We present our 6-year results of using the V.A.C.® system in surgical site infection with involved vascular grafts. A retrospective 6-year review of patient who underwent a VAC® therapy for postoperative surgical site infection in lower limb with involved vascular grafts in our department between January 2006 and December 2011. V.A.C therapy was used in 40 patients. All patients underwent surgical wound revision with VAC® therapy and antibiotics. The mean time of use of the V.A.C. system was 14.2 days. After mean of 12 days in 34 of 40 patients, in whom the use of VAC® therapy resulted in delayed primary closure or healing by secondary intention. The mean postoperative follow-up time was 61.67 months, during which 3 patients died. We showed that the V.A.C.® system is valuable for managing specifically surgical site infection with involved vascular grafts. Using the V.A.C.® system, reoperation rates are reduced; 85% of patients avoided graft replacement. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  17. National Space Transportation System (NSTS) technology needs

    Science.gov (United States)

    Winterhalter, David L.; Ulrich, Kimberly K.

    1990-01-01

    The National Space Transportation System (NSTS) is one of the Nation's most valuable resources, providing manned transportation to and from space in support of payloads and scientific research. The NSTS program is currently faced with the problem of hardware obsolescence, which could result in unacceptable schedule and cost impacts to the flight program. Obsolescence problems occur because certain components are no longer being manufactured or repair turnaround time is excessive. In order to achieve a long-term, reliable transportation system that can support manned access to space through 2010 and beyond, NASA must develop a strategic plan for a phased implementation of enhancements which will satisfy this long-term goal. The NSTS program has initiated the Assured Shuttle Availability (ASA) project with the following objectives: eliminate hardware obsolescence in critical areas, increase reliability and safety of the vehicle, decrease operational costs and turnaround time, and improve operational capability. The strategy for ASA will be to first meet the mandatory needs - keep the Shuttle flying. Non-mandatory changes that will improve operational capability and enhance performance will then be considered if funding is adequate. Upgrade packages should be developed to install within designated inspection periods, grouped in a systematic approach to reduce cost and schedule impacts, and allow the capability to provide a Block 2 Shuttle (Phase 3).

  18. Transport in low-dimensional mesoscopic systems

    Energy Technology Data Exchange (ETDEWEB)

    Syzranov, Sergey

    2011-05-05

    The work is devoted to the physics of graphene-based optoelectronics and arrays of Josephson junctions. The first part deals with transport in a graphene p-n junction irradiated by an electromagnetic field. The photocurrent in such device is calculated analytically and compared to those observed in the recent experiments on graphene photodetectors. It is shown that in a clean effectively one-dimensional junction the photocurrent oscillates as a function of gate voltages due to the interference between electron paths accompanied by the resonant photon absorption. The second part of the thesis is devoted to the construction of a Drude-like theory for the transport of Cooper pairs in weakly disordered Josephson networks and to finding the conductivity and the characteristic temperature of the commencement of strong localization. Also, it is shown that the low-temperature superconductor-insulator transition is necessarily of the first order in all 3D and in most 2D systems.

  19. Tomorrow's Transportation Market : Developing an Innovative, Seamless Transportation System

    Science.gov (United States)

    2013-04-17

    With the cost of congestion in the United States estimated to be in the order of $121 billion, transportation planners are under increasing pressure to improve conditions and meet projected demand increases. Harnessing emerging technologies to develo...

  20. Design of a hydraulic ash transport system

    Energy Technology Data Exchange (ETDEWEB)

    Mirgorodskii, V.G.; Mova, M.E.; Korenev, V.E.; Grechikhin, Yu.A. (Donetskii Politekhnicheskii Institut (USSR))

    1990-04-01

    Discusses general design of a hydraulic ash removal system to be employed at the reconstructed six 225 MW blocks of the Mironov State Regional Power Plant in the USSR. The blocks burn low-grade solid fuel with an ash content of up to 40.5%. Large quantities of ash have to be moved from the plant (total ash production 60 t/h, using 570 t/h of water for cooling and moistening). An optimum hydraulic ash transportation system would include a two-section airlift pumping system, shown in a diagram. Technological advantages of using this airlift system are enumerated, including short pipes, reduction in required water quantity and the possibility of siting hydraulic pumps at zero level.

  1. Accelerating technological change. Towards a more sustainable transport system

    NARCIS (Netherlands)

    van der Vooren, A.

    2014-01-01

    This thesis provides insights into the mechanisms of technological change by capturing the complexity that characterises the current technological transition of the transport system into existing evolutionary models of technological change. The transition towards a more sustainable transport system

  2. Intelligent transport systems (UTS) and driving behaviour: setting the agenda

    NARCIS (Netherlands)

    Heijden, R.E.C.M. van der; Marchau, V.A.W.J.; Thissen, W.A.H.; Wieinga, P.; Pantic, M.; Ludema, M.

    2004-01-01

    The application of intelligent transportation systems (ITS), in particular advanced driver assistance systems (ADAS), is expected to improve the performance of road transportation significantly. Public policy makers, among others, are therefore increasingly interested in the implementation

  3. Selected legal and regulatory concerns affecting domestic energy transportation systems

    International Nuclear Information System (INIS)

    Schuller, C.R.

    1979-07-01

    This report provides assessments of eight legal and regulatory concerns that may affect energy material transportation in the US during the rest of the century: state authority to regulate nuclear materials transport, divestiture of petroleum pipelines from major integrated oil companies, problems affecting the natural gas transportation system, capabilities of energy transportation systems during emergencies, Federal coal pipeline legislation, ability of Federal agencies to anticipate railroad difficulties, abandonment of uneconomic railroad lines, and impact of the Panama Canal treaty upon US energy transportation

  4. Intermodal transport as an integral part of logistics system

    Directory of Open Access Journals (Sweden)

    Agnieszka Bitkowska

    2016-06-01

    Full Text Available The experience of companies that are successful in the carriage of goods prove that intermodal transport is now a major factor in determining the success of logistics system. A modern approach to the transport is based on intermodal transport. The article is based on the method of external observation. It presents the essence of intermodal transport and its benefits. It specifies transportation as an integral part of logistics system.

  5. [The age-related macular degeneration as a vascular disease/part of systemic vasculopathy: contributions to its pathogenesis].

    Science.gov (United States)

    Fischer, Tamás

    2015-03-01

    The wall of blood vessels including those in choroids may be harmed by several repeated and/or prolonged mechanical, physical, chemical, microbiological, immunologic, and genetic impacts (risk factors), which may trigger a protracted response, the so-called host defense response. As a consequence, pathological changes resulting in vascular injury (e. g. atherosclerosis, age-related macular degeneration) may be evolved. Risk factors can also act directly on the endothelium through an increased production of reactive oxygen species promoting an endothelial activation, which leads to endothelial dysfunction, the onset of vascular disease. Thus, endothelial dysfunction is a link between the harmful stimulus and vascular injury; any kind of harmful stimuli may trigger the defensive chain that results in inflammation that may lead to vascular injury. It has been shown that even early age-related macular degeneration is associated with the presence of diffuse arterial disease and patients with early age-related macular degeneration demonstrate signs of systemic and retinal vascular alterations. Chronic inflammation, a feature of AMD, is tightly linked to diseases associated with ED: AMD is accompanied by a general inflammatory response, in the form of complement system activation, similar to that observed in degenerative vascular diseases such as atherosclerosis. All these facts indicate that age-related macular degeneration may be a vascular disease (or part of a systemic vasculopathy). This recognition could have therapeutic implications because restoration of endothelial dysfunction may prevent the development or improve vascular disease resulting in prevention or improvement of age-related macular degeneration as well.

  6. Transport systems and policies for sustainable cities

    Directory of Open Access Journals (Sweden)

    Vučić Vukan R.

    2008-01-01

    Full Text Available The 20th century witnessed revolutionary developments in transportation technology with major impacts on the form and character of cities. Progress in increasing mobility has brought many benefits as well as serious problems, particularly in deterioration of livability and sustainability. Increase in auto ownership led to serious problems of chronic traffic congestion. Attempts to rebuild cities to provide full accommodation of private cars have led to serious problems of auto dependency and deterioration of cities. Experiences from recent decades have shown that urban transportation is much more complex than usually realized. Livable and sustainable cities require policies that lead to creation of a transportation system consisting of coordinated public transit and private cars, and encourages pedestrian environment and efficient, sustainable development. Great need for better understanding of the complex problems in implementing incentives and disincentives aimed at achieving intermodal balance is emphasized. Brief descriptions of cities which lead in achieving such livable conditions is followed by a summary of lessons and guidelines for the future.

  7. Study of a transportable neutron radiography system

    International Nuclear Information System (INIS)

    Souza, S.N.A. de.

    1991-05-01

    This work presents a study a transportable neutron radiography system for a 185 GBq 241 Am-Be (α, η) source with a neutron yield roughly 1,25 x 10 7 n/s. Studies about moderation, collimation and shielding are showed. In these studies, a calculation using Transport Theory was carried out by means of transport codes ANISN and DOT (3.5). Objectives were: to obtain a maximum and more homogeneous thermal neutron flux in the collimator outlet to the image plain, and an adequate radiation shielding to attend radiological protection rules. With the presented collimator, it was possible to obtain for the thermal neutron flux, at the collimator outlet and next to the image plain, a L/D ratio of 14, for neutron fluxes up to 4,09 x 10 2 n.cm -2 .s -1 . Considering the low intensity of the source, it is a good value. Studies have also been carried out for L/D ratios of 22 and 30, giving thermal neutron fluxes at the image plain of 1,27 x 10 2 n.cm -2 .s -1 and 2,65 x 10 2 n.cm -2 .s -1 , respectively. (author). 30 refs, 39 figs, 9 tabs

  8. Influence of Fasciola Hepatica on Serum Biochemical Parameters and Vascular and Biliary System of Sheep Liver

    Directory of Open Access Journals (Sweden)

    A Hodžić

    2013-03-01

    Full Text Available Background: The aim of this study was to evaluate the functional capacity of the liver based on the activity of specific enzymes and bilirubin in serum and also to investigate the influence of mechanical and toxic effects of Fasciola hepatica on the structures of the blood vessels and biliary tract in the sheep liver.Methods: Blood samples and liver of 63 indigenous sheep of Pramenka breed, slaughtered in the period from March to December 2009 were used. Based on parasitological findings in the liver, all animals were divided into two groups: control (n=34 and infected group (n=29. For investigation and description of pathological changes in sheep liver, naturally infected with F. hepatica, corrosion cast technique was used.Results: Biochemical analysis of tested parameters showed a significant elevation (P≤0.05 of serum gamma-glutamyl transferase (GGT, total bilirubin (TBIL and direct bilirubin (DBIL in infected sheep group comparing with the control group. No significant differences were observed for activity of aspartate aminotranferase (AST between groups. Vascular and biliary systems of the liver were found to be affected.Conclusion: Results of biochemical analysis are consistent with pathological findings and measuring of tested parameters could be used in early diagnosis of sheep fasciolosis and to test the effectiveness of anthelmintic therapy. Corrosion cast technique is very useful for investigation of pathological changes and neoangiogenesis of vascular and biliary system in sheep liver, caused by mechanical and toxic effects of F. hepatica.

  9. Operating systems in the air transportation environment.

    Science.gov (United States)

    Cherry, G. W.

    1971-01-01

    Consideration of the problems facing air transport at present, and to be expected in the future. In the Northeast Corridor these problems involve community acceptance, airway and airport congestion and delays, passenger acceptance, noise reduction, and improvements in low-density short-haul economics. In the development of a superior short-haul operating system, terminal-configured vs cruise-configured vehicles are evaluated. CTOL, STOL, and VTOL aircraft of various types are discussed. In the field of noise abatement, it is shown that flight procedural techniques are capable of supplementing ?quiet engine' technology.

  10. Investments and Operation in an Integrated Power and Transport System

    DEFF Research Database (Denmark)

    Juul, Nina; Boomsma, Trine Krogh

    2013-01-01

    This chapter analyses an integrated power and road transport system. For analysing the influences of including passenger road transport in the energy system, a road transport model is developed. Based on this model, the benefits of integration of the two systems and using electric-drive vehicles ...

  11. Third-order TRANSPORT: A computer program for designing charged particle beam transport systems

    International Nuclear Information System (INIS)

    Carey, D.C.; Brown, K.L.; Rothacker, F.

    1995-05-01

    TRANSPORT has been in existence in various evolutionary versions since 1963. The present version of TRANSPORT is a first-, second-, and third-order matrix multiplication computer program intended for the design of static-magnetic beam transport systems. This report discusses the following topics on TRANSPORT: Mathematical formulation of TRANSPORT; input format for TRANSPORT; summaries of TRANSPORT elements; preliminary specifications; description of the beam; physical elements; other transformations; assembling beam lines; operations; variation of parameters for fitting; and available constraints -- the FIT command

  12. Arabidopsis thickvein Mutation Affects Vein Thickness and Organ Vascularization, and Resides in a Provascular Cell-Specific Spermine Synthase Involved in Vein Definition and in Polar Auxin Transport1

    Science.gov (United States)

    Clay, Nicole K.; Nelson, Timothy

    2005-01-01

    Polar auxin transport has been implicated in the induction of vascular tissue and in the definition of vein positions. Leaves treated with chemical inhibitors of polar auxin transport exhibited vascular phenotypes that include increased vein thickness and vascularization. We describe a recessive mutant, thickvein (tkv), which develops thicker veins in leaves and in inflorescence stems. The increased vein thickness is attributable to an increased number of vascular cells. Mutant plants have smaller leaves and shorter inflorescence stems, and this reduction in organ size and height is accompanied by an increase in organ vascularization, which appears to be attributable to an increase in the recruitment of cells into veins. Furthermore, although floral development is normal, auxin transport in the inflorescence stem is significantly reduced in the mutant, suggesting that the defect in auxin transport is responsible for the vascular phenotypes. In the primary root, the veins appear morphologically normal, but root growth in the tkv mutant is hypersensitive to exogenous cytokinin. The tkv mutation was found to reside in the ACL5 gene, which encodes a spermine synthase and whose expression is specific to provascular cells. We propose that ACL5/TKV is involved in vein definition (defining the boundaries between veins and nonvein regions) and in polar auxin transport, and that polyamines are involved in this process. PMID:15894745

  13. Application of the transport system concept to the transport of LSA waste

    International Nuclear Information System (INIS)

    Lombard, J.; Appleton, P.; Libon, H.; Sannen, H.

    1994-01-01

    The aim of this presentation is to illustrate using two examples how a particular special arrangement can be envisaged for the transport of a well defined category of waste according to the ''Transport System Concept''. (authors)

  14. A radioactive waste transportation package monitoring system for normal transport and accident emergency response conditions

    International Nuclear Information System (INIS)

    Brown, G.S.; Cashwell, J.W.; Apple, M.L.

    1993-01-01

    This paper addresses spent fuel and high level waste transportation history and prospects, discusses accident histories of radioactive material transport, discusses emergency responder needs and provides a general description of the Transportation Intelligent Monitoring System (TRANSIMS) design. The key objectives of the monitoring system are twofold: (1) to facilitate effective emergency response to accidents involving a radioactive waste transportation package, while minimizing risk to the public and emergency first-response personnel, and (2) to allow remote monitoring of transportation vehicle and payload conditions to enable research into radioactive material transportation for normal and accident conditions. (J.P.N.)

  15. Road Transportable Analytical Laboratory (RTAL) system

    International Nuclear Information System (INIS)

    Finger, S.M.

    1995-01-01

    U.S. Department of Energy (DOE) facilities around the country have, over the years, become contaminated with radionuclides and a range of organic and inorganic wastes. Many of the DOE sites encompass large land areas and were originally sited in relatively unpopulated regions of the country to minimize risk to surrounding populations. In addition, wastes were sometimes stored underground at the sites in 55-gallon drums, wood boxes or other containers until final disposal methods could be determined. Over the years, these containers have deteriorated, releasing contaminants into the surrounding environment. This contamination has spread, in some cases polluting extensive areas. Remediation of these sites requires extensive sampling to determine the extent of the contamination, to monitor clean-up and remediation progress, and for post-closure monitoring of facilities. The DOE would benefit greatly if it had reliable, road transportable, fully independent laboratory systems that could perform on-site the full range of analyses required. Such systems would accelerate and thereby reduce the cost of clean-up and remediation efforts by (1) providing critical analytical data more rapidly, and (2) eliminating the handling, shipping and manpower associated with sample shipments. The goal of the Road Transportable Analytical Laboratory (RTAL) Project is the development and demonstration of a system to meet the unique needs of the DOE for rapid, accurate analysis of a wide variety of hazardous and radioactive contaminants in soil, groundwater, and surface waters. This laboratory system has been designed to provide the field and laboratory analytical equipment necessary to detect and quantify radionuclides, organics, heavy metals and other inorganic compounds. The laboratory system consists of a set of individual laboratory modules deployable independently or as an interconnected group to meet each DOE site's specific needs

  16. Anatomy and arterial vascularization of female genital system of margay (Leopardus weidii

    Directory of Open Access Journals (Sweden)

    Andrezza Braga Soares Silva

    2016-02-01

    Full Text Available The margay (Leopardus wiedii belongs to Carnivora order and present’s nocturnal habits. There are few studies using this specie, whereas it is between feline species vulnerable to extinction. Thus, we propose a descriptive study about female genital system and behavior of the arteries responsible for the blood supply to these organs in margay. It used one exemplary victim of poaching that to death. The animal was stored in freezer. Subsequent to defrost at room temperature, it proceeded with the solution injection Leoprene Latex ‘650’ colored in red for better identification of vessels before the adjacent strutures. The specimen was fixed using an aqueous 10% formaldehyde with subsequent immersion in the same fixative solution. The genital system were dissected and the organs and arterial branches were identified and photodocumented. The female genital system of margay consists of a pair of ovaries, uterus with a pair of uterine horns, vagina and vulva. The arterial distribution of female system have a common vessel to iliac artery which branches and leads to internal pudendal artery sends a branch along the pudendal nerve pathway, urogenital artery. This, we performed divided into two branches, cranial and caudal. The cranial branch irrigates laterally cervix and uterine horns and caudal branch, vagina and vulva. The ovarian arteries, peers, originate from abdominal aorta only vascularization the ovaries. The female genital system and vascularization of the genitals organs of margay resembles of domestic carnivores including cats and some wild felines like the ocelot and find differences with the same description held in other domestic and wild species.

  17. Risk management model in road transport systems

    Science.gov (United States)

    Sakhapov, R. L.; Nikolaeva, R. V.; Gatiyatullin, M. H.; Makhmutov, M. M.

    2016-08-01

    The article presents the results of a study of road safety indicators that influence the development and operation of the transport system. Road safety is considered as a continuous process of risk management. Authors constructed a model that relates the social risks of a major road safety indicator - the level of motorization. The model gives a fairly accurate assessment of the level of social risk for any given level of motorization. Authors calculated the dependence of the level of socio-economic costs of accidents and injured people in them. The applicability of the concept of socio-economic damage is caused by the presence of a linear relationship between the natural and economic indicators damage from accidents. The optimization of social risk is reduced to finding the extremum of the objective function that characterizes the economic effect of the implementation of measures to improve safety. The calculations make it possible to maximize the net present value, depending on the costs of improving road safety, taking into account socio-economic damage caused by accidents. The proposed econometric models make it possible to quantify the efficiency of the transportation system, allow to simulate the change in road safety indicators.

  18. Innovative technology summary report: Transportable vitrification system

    International Nuclear Information System (INIS)

    1998-09-01

    At the end of the cold war, many of the Department of Energy's (DOE's) major nuclear weapons facilities refocused their efforts on finding technically sound, economic, regulatory compliant, and stakeholder acceptable treatment solutions for the legacy of mixed wastes they had produced. In particular, an advanced stabilization process that could effectively treat the large volumes of settling pond and treatment sludges was needed. Based on this need, DOE and its contractors initiated in 1993 the EM-50 sponsored development effort required to produce a deployable mixed waste vitrification system. As a consequence, the Transportable Vitrification System (TVS) effort was undertaken with the primary requirement to develop and demonstrate the technology and associated facility to effectively vitrify, for compliant disposal, the applicable mixed waste sludges and solids across the various DOE complex sites. After 4 years of development testing with both crucible and pilot-scale melters, the TVS facility was constructed by Envitco, evaluated and demonstrated with surrogates, and then successfully transported to the ORNL ETTP site and demonstrated with actual mixed wastes in the fall of 1997. This paper describes the technology, its performance, the technology applicability and alternatives, cost, regulatory and policy issues, and lessons learned

  19. Road Transportable Analytical Laboratory (RTAL) system

    International Nuclear Information System (INIS)

    Finger, S.M.

    1995-01-01

    U.S. Department of Energy (DOE) facilities around the country have, over the years, become contaminated with radionuclides and a range of organic and inorganic wastes. Many of the DOE sites encompass large land areas and were originally sited in relatively unpopulated regions of the country to minimize risk to surrounding populations. In addition, wastes were sometimes stored underground at the sites in 55-gallon drums, wood boxes or other containers until final disposal methods could be determined. Over the years, these containers have deteriorated, releasing contaminants into the surrounding environment. This contamination has spread, in some cases polluting extensive areas. The DOE would benefit greatly if it had reliable, road transportable, fully independent laboratory systems that could perform on-site the full range of analyses required. The goal of the Road Transportable Analytical Laboratory (RTAL) project is the development and demonstration of a system to meet the unique needs of the DOE for rapid, accurate analysis of a wide variety of hazardous and radioactive contaminants in soils, ground water and surface waters. This document describes the requirements for such a laboratory

  20. A multidimensonal Examination of Prefomences of the Future advanced Transport Systems: The ETT (Evacuated Tube Transport) TRM (Transrapid MAGLEV) System

    NARCIS (Netherlands)

    Janic, M.

    2016-01-01

    Multidimensional examination of performances of the future advanced ETT Evacuated Tube Transport) system operated by TRM (TransRapidMaglev); assessment of the ETT TRM system contribution to sustainability of the future transport sector through its completion with APT (Air Passenger Transport) system

  1. Increased NBCn1 expression, Na+/ HCO 3 ? co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension

    OpenAIRE

    Ng, Fu Liang; Boedtkjer, Ebbe; Witkowska, Kate; Ren, Meixia; Zhang, Ruoxin; Tucker, Arthur; Aalkj?r, Christian; Caulfield, Mark J.; Ye, Shu

    2017-01-01

    Abstract Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/ HCO 3 ? co-transporter NBCn1 which regulates intracellular pH (pH i ). We conducted a functional study of variants at this locus in primary cultures of vascular smooth muscle and endothelial cells. In both cell types, we found genotype-dependent differences for rs13082711 in DNA-nuclear protein interactions, where the risk allel...

  2. TRANSPORT PROPERTIES OF THE STRONGLY CORRELATED SYSTEMS

    Directory of Open Access Journals (Sweden)

    T.Domanski

    2004-01-01

    Full Text Available The transport properties of various systems are studied here in the context of three different models. These are: - the disordered Hubbard model applicable to correlated binary alloys with a general disorder, - the Anderson model used in describing the Kondo physics of a quantum dot connected to the external superconducting leads, and - the Ranninger-Robaszkiewicz model applied to the study of optical properties of the system with preformed electron pairs above the temperature of transition to the superconducting state. We calculate the density of states, specific heat, the Wilson ratio and conductivity of the correlated binary alloy with off-diagonal disorder. We investigate the conditions under which the Kondo peak appears in the density of states and in the conductance of a dot coupled to the external superconducting leads. We analyze the effect of the pseudogap on the optical spectra in the high temperature superconductors described by the boson-fermion model.

  3. Sensor system for fuel transport vehicle

    Science.gov (United States)

    Earl, Dennis Duncan; McIntyre, Timothy J.; West, David L.

    2016-03-22

    An exemplary sensor system for a fuel transport vehicle can comprise a fuel marker sensor positioned between a fuel storage chamber of the vehicle and an access valve for the fuel storage chamber of the vehicle. The fuel marker sensor can be configured to measure one or more characteristics of one or more fuel markers present in the fuel adjacent the sensor, such as when the marked fuel is unloaded at a retail station. The one or more characteristics can comprise concentration and/or identity of the one or more fuel markers in the fuel. Based on the measured characteristics of the one or more fuel markers, the sensor system can identify the fuel and/or can determine whether the fuel has been adulterated after the marked fuel was last measured, such as when the marked fuel was loaded into the vehicle.

  4. Quantum Transport in Strongly Correlated Systems

    DEFF Research Database (Denmark)

    Bohr, Dan

    2007-01-01

    the density matrix renormalization group (DMRG) method. We present two DMRG setups for calculating the linear conductance of strongly correlated nanostructures in the infinitesimal source-drain voltage regime. The first setup describes the leads by modified real-space tight-binding chains, whereas the second....... Thus both coherence and correlation effects are important in this model, and the methods applied should be able to handle both these effects rigorously. We present the DMRG setup for this model and benchmark against existing Greens function results for the model. Then we present initial DMRG results...... screening plays a much less significant role than in bulk systems due to the reduced size of the objects, therefore making it necessary to consider the importance of correlations between electrons. The work presented in this thesis deals with quantum transport through strongly correlated systems using...

  5. Mobilization of endothelial precursor cells: systemic vascular response to musculoskeletal trauma.

    LENUS (Irish Health Repository)

    Laing, A J

    2012-02-03

    Postnatal vasculogenesis, the process by which vascular committed bone marrow stem cells or endothelial precursor cells (EPC) migrate, differentiate, and incorporate into the nacent endothelium contributing to physiological and pathological neovascularization, has stimulated much interest. Its contribution to tumor nonvascularization, wound healing, and revascularization associated with skeletal and cardiac muscles ischaemia is established. We evaluated the mobilization of EPCs in response to musculoskeletal trauma. Blood from patients (n = 15) following AO type 42a1 closed diaphyseal tibial fractures was analyzed for CD34 and AC133 cell surface marker expression. Immunomagnetically enriched CD34+ mononuclear cell (MNC(CD34+)) populations were cultured and examined for phenotypic and functional vascular endothelial differentiation. Circulating MNC(CD34+) levels increased sevenfold by day 3 postinjury. Circulating MNC(AC133+) increased 2.5-fold. Enriched MNC(CD34+) populations from day 3 samples in culture exhibited cell cluster formation with sprouting spindles. These cells bound UEA-1 and incorporated fluorescent DiI-Ac-LDL intracellularily. Our findings suggest a systemic provascular response is initiated in response to musculoskeletal trauma. Its therapeutic manipulation may have implications for the potential enhancement of fracture healing.

  6. A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage

    Directory of Open Access Journals (Sweden)

    Katharina Niopek

    2017-08-01

    Full Text Available Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration sites remain largely unknown. Here, we identify the heterodimerization interface between the α and β subunits of transcription factor GA-binding protein (GAbp as a negative target of tumor necrosis factor alpha (TNF-α signaling. TNF-α prevented GAbpα and β complex formation via reactive oxygen species (ROS, leading to the non-energy-dependent transcriptional inactivation of AMP-activated kinase (AMPK β1, which was identified as a direct hepatic GAbp target. Impairment of AMPKβ1, in turn, elevated downstream cellular cholesterol biosynthesis, and hepatocyte-specific ablation of GAbpα induced systemic hypercholesterolemia and early macro-vascular lesion formation in mice. As GAbpα and AMPKβ1 levels were also found to correlate in obese human patients, the ROS-GAbp-AMPK pathway may represent a key component of a hepato-vascular axis in diabetic long-term complications.

  7. Salicylic acid prevents Trichoderma harzianum from entering the vascular system of roots.

    Science.gov (United States)

    Alonso-Ramírez, Ana; Poveda, Jorge; Martín, Ignacio; Hermosa, Rosa; Monte, Enrique; Nicolás, Carlos

    2014-10-01

    Trichoderma is a soil-borne fungal genus that includes species with a significant impact on agriculture and industrial processes. Some Trichoderma strains exert beneficial effects in plants through root colonization, although little is known about how this interaction takes place. To better understand this process, the root colonization of wild-type Arabidopsis and the salicylic acid (SA)-impaired mutant sid2 by a green fluorescent protein (GFP)-marked Trichoderma harzianum strain was followed under confocal microscopy. Trichoderma harzianum GFP22 was able to penetrate the vascular tissue of the sid2 mutant because of the absence of callose deposition in the cell wall of root cells. In addition, a higher colonization of sid2 roots by GFP22 compared with that in Arabidopsis wild-type roots was detected by real-time polymerase chain reaction. These results, together with differences in the expression levels of plant defence genes in the roots of both interactions, support a key role for SA in Trichoderma early root colonization stages. We observed that, without the support of SA, plants were unable to prevent the arrival of the fungus in the vascular system and its spread into aerial parts, leading to later collapse. © 2014 BSPP AND JOHN WILEY & SONS LTD.

  8. Systemic Hypoxia Changes the Organ-Specific Distribution of Vascular Endothelial Growth Factor and Its Receptors

    Science.gov (United States)

    Marti, Hugo H.; Risau, Werner

    1998-12-01

    Vascular endothelial growth factor (VEGF) plays a key role in physiological blood vessel formation and pathological angiogenesis such as tumor growth and ischemic diseases. Hypoxia is a potent inducer of VEGF in vitro. Here we demonstrate that VEGF is induced in vivo by exposing mice to systemic hypoxia. VEGF induction was highest in brain, but also occurred in kidney, testis, lung, heart, and liver. In situ hybridization analysis revealed that a distinct subset of cells within a given organ, such as glial cells and neurons in brain, tubular cells in kidney, and Sertoli cells in testis, responded to the hypoxic stimulus with an increase in VEGF expression. Surprisingly, however, other cells at sites of constitutive VEGF expression in normal adult tissues, such as epithelial cells in the choroid plexus and kidney glomeruli, decreased VEGF expression in response to the hypoxic stimulus. Furthermore, in addition to VEGF itself, expression of VEGF receptor-1 (VEGFR-1), but not VEGFR-2, was induced by hypoxia in endothelial cells of lung, heart, brain, kidney, and liver. VEGF itself was never found to be up-regulated in endothelial cells under hypoxic conditions, consistent with its paracrine action during normoxia. Our results show that the response to hypoxia in vivo is differentially regulated at the level of specific cell types or layers in certain organs. In these tissues, up- or down-regulation of VEGF and VEGFR-1 during hypoxia may influence their oxygenation after angiogenesis or modulate vascular permeability.

  9. Pulmonary allergic reactions impair systemic vascular relaxation in ragweed sensitive mice.

    Science.gov (United States)

    Hazarika, Surovi; Van Scott, Michael R; Lust, Robert M; Wingard, Christopher J

    2010-01-01

    Asthma is often associated with cardiovascular complications, and recent observations in animal models indicate that induction of pulmonary allergic inflammation increases susceptibility of the myocardium to ischemia and reperfusion injury. In this study, we used a murine model of allergen sensitization in which aspiration of allergen induces pulmonary and systemic inflammation, to test the hypothesis that pulmonary exposure to allergen alters vascular relaxation responses. BALB/C mice were sensitized by intraperitoneal injection of ragweed and challenged by intratracheal instillation of allergen. Airway hyperreactivity and pulmonary inflammation were confirmed, and endothelium-dependent and -independent reactivity of thoracic aorta rings were evaluated. Ragweed sensitization and challenge induced airway hyperreactivity to methacholine and pulmonary inflammation, but did not affect constrictor responses of the aortic rings to phenylephrine and K+ depolarization. In contrast, maximal relaxation of aortic rings to acetylcholine and sodium nitroprusside decreased from 87.6±3.9% and 97.7±1.2% to 32±4% and 51±6%, respectively (p<0.05). The sensitivity to acetylcholine was likewise reduced (EC₅₀=0.26±0.05 μM vs. 1.09±0.16 μM, p<0.001). The results demonstrate that induction of allergic pulmonary inflammation in mice depresses endothelium-dependent and -independent vascular relaxation, which can contribute to cardiovascular complications associated with allergic inflammation. Copyright © 2010 Elsevier Inc. All rights reserved.

  10. Road Transportable Analytical Laboratory system. Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Finger, S.M.; Keith, V.F.; Spertzel, R.O.; De Avila, J.C.; O`Donnell, M.; Vann, R.L.

    1993-09-01

    This developmental effort clearly shows that a Road Transportable Analytical Laboratory System is a worthwhile and achievable goal. The RTAL is designed to fully analyze (radioanalytes, and organic and inorganic chemical analytes) 20 samples per day at the highest levels of quality assurance and quality control. It dramatically reduces the turnaround time for environmental sample analysis from 45 days (at a central commercial laboratory) to 1 day. At the same time each RTAL system will save the DOE over $12 million per year in sample analysis costs compared to the costs at a central commercial laboratory. If RTAL systems were used at the eight largest DOE facilities (at Hanford, Savannah River, Fernald, Oak Ridge, Idaho, Rocky Flats, Los Alamos, and the Nevada Test Site), the annual savings would be $96,589,000. The DOE`s internal study of sample analysis needs projects 130,000 environmental samples requiring analysis in FY 1994, clearly supporting the need for the RTAL system. The cost and time savings achievable with the RTAL system will accelerate and improve the efficiency of cleanup and remediation operations throughout the DOE complex.

  11. Integral Transportation Systems in Military Transport Aircraft Supply

    Directory of Open Access Journals (Sweden)

    Dražen Kovačević

    2012-10-01

    Full Text Available Supply of goods, equipment and soldiers by militwy transportaircraft can serve as a support to airborne landing operation,support to encircled forces, and support to forces leadinga gue1rilla war. Transport aircraft are designed in such a wayas to be able to cany containers, pallets, most of land vehiclesand helicopters. Militwy transport aircraft can be grouped intothose that were originally designed for military transp01t andthose that are modified civilian aircraft and helicopters. Supplypallets can be wooden, metal, can be airdropped in "taxiing","low-flight", and can also be fitted with a parachute or"retrorocket" for reducing the ground impact. Pallets canamong other things carry liquids, heavy combat and ca1rier vehicles,artillery and rocket weapons and valious containers.Pallets are usually pe1manently deformed at ground impact.Nowadays, high precision of airdrop has been achieved. Containersare used to carry various equipment, food, fue~ weapons,ammunition etc. It is to be expected that the containers,wmoured combat and other vehicles will be redesigned so asto provide more efficient transport and fast a!Tangement ofhigh-mobility units, whereas the form of the future militarytransport aircraft will not undergo substantial changes. By adjustingand standardising the transporlation vehicles, integraltransportation means and cwgo, the overall combat efficiencywill be increased, the a~rangement time especially shortenedand the air supply safety increased.

  12. Vertical Transport by Coastal Mesoscale Convective Systems

    Science.gov (United States)

    Lombardo, K.; Kading, T.

    2016-12-01

    This work is part of an ongoing investigation of coastal mesoscale convective systems (MCSs), including changes in vertical transport of boundary layer air by storms moving from inland to offshore. The density of a storm's cold pool versus that of the offshore marine atmospheric boundary layer (MABL), in part, determines the ability of the storm to successfully cross the coast, the mechanism driving storm propagation, and the ability of the storm to lift air from the boundary layer aloft. The ability of an MCS to overturn boundary layer air can be especially important over the eastern US seaboard, where warm season coastal MCSs are relatively common and where large coastal population centers generate concentrated regions of pollution. Recent work numerically simulating idealized MCSs in a coastal environment has provided some insight into the physical mechanisms governing MCS coastal crossing success and the impact on vertical transport of boundary layer air. Storms are simulated using a cloud resolving model initialized with atmospheric conditions representative of a Mid-Atlantic environment. Simulations are run in 2-D at 250 m horizontal resolution with a vertical resolution stretched from 100 m in the boundary layer to 250 m aloft. The left half of the 800 km domain is configured to represent land, while the right half is assigned as water. Sensitivity experiments are conducted to quantify the influence of varying MABL structure on MCS coastal crossing success and air transport, with MABL values representative of those observed over the western Mid-Atlantic during warm season. Preliminary results indicate that when the density of the cold pool is much greater than the MABL, the storm successfully crosses the coastline, with lifting of surface parcels, which ascend through the troposphere. When the density of the cold pool is similar to that of the MABL, parcels within the MABL remain at low levels, though parcels above the MABL ascend through the troposphere.

  13. Propagating fronts in reaction-transport systems with memory

    Energy Technology Data Exchange (ETDEWEB)

    Yadav, A. [Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314 (United States)], E-mail: ayadav1@lsu.edu; Fedotov, Sergei [School of Mathematics, University of Manchester, Manchester M60 1DQ (United Kingdom)], E-mail: sergei.fedotov@manchester.ac.uk; Mendez, Vicenc [Grup de Fisica Estadistica, Departament de Fisica, Universitat Autonoma de Barcelona, E-08193 Bellaterra (Spain)], E-mail: vicenc.mendez@uab.es; Horsthemke, Werner [Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314 (United States)], E-mail: whorsthe@smu.edu

    2007-11-26

    In reaction-transport systems with non-standard diffusion, the memory of the transport causes a coupling of reactions and transport. We investigate the effect of this coupling for systems with Fisher-type kinetics and obtain a general analytical expression for the front speed. We apply our results to the specific case of subdiffusion.

  14. Sustainable Transportation Systems Research Group: Ongoing and Past Activities

    OpenAIRE

    Gkritza, Konstantina "Nadia"; Hurtado, Davis Chacon; Gkartzonikas, Christos; Ke, Yue; Losada, Lisa L

    2017-01-01

    This presentation describes the ongoing and past activities of the Sustainable Transportation Systems Research (STSR) group at Purdue University (https://engineering.purdue.edu/STSRG). The STSR group aims to achieve green, safe, efficient, and equitable transportation systems by studying and modeling transportation externalities, using state of the art statistical, econometric, and economic analysis tools.

  15. 77 FR 57640 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-09-18

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... intelligent transportation systems. Through its sponsor, the ITS Joint Program Office, the ITS PAC makes...

  16. 78 FR 64048 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-10-25

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... implementation of intelligent transportation systems. Through its sponsor, the ITS Joint Program Office (JPO...

  17. 77 FR 20872 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-04-06

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory..., development, and implementation of intelligent transportation systems. Through its sponsor, the ITS Joint...

  18. 77 FR 51845 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-08-27

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory..., development, and implementation of intelligent transportation systems. Through its sponsor, the ITS Joint...

  19. 77 FR 26067 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2012-05-02

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... of intelligent transportation systems. Through its sponsor, the ITS Joint Program Office, the ITS PAC...

  20. Picosecond excitation transport in disordered systems

    International Nuclear Information System (INIS)

    Hart, D.E.

    1987-11-01

    Time-resolved fluorescence decay profiles are used to study excitation transport in 2- and 3-dimensional disordered systems. Time-correlated single photon counting detection is used to collect the fluorescence depolarization data. The high signal-to-noise ratios afforded by this technique makes it possible to critically examine current theories of excitation transport. Care has been taken to eliminate or account for the experimental artifacts common to this type of study. Solutions of 3,3'-diethyloxadicarbocyanine iodide (DODCI) in glycerol serve as a radomly distributed array of energy donors in 3-dimensions. A very thin sample cell (/approximately/ 2 μm) is used to minimize the effects of fluorescence self-absorption on the decay kinetics. Evidence of a dynamic shift of the fluorescence spectrum of DODCI in glycerol due to solvent reorganization is presented. The effects of excitation trapping on the decay profiles is minimized in the data analysis procedure. The 3-body theory of Gochanour, Andersen, and Fayer (GAF) and the far less complex 2-particle analytic theory of Huber, Hamilton, and Barnett yield indistinguishable fits to the data over the wide dynamic range of concentrations and decay times studied

  1. Wireless Battery Management System of Electric Transport

    Science.gov (United States)

    Rahman, Ataur; Rahman, Mizanur; Rashid, Mahbubur

    2017-11-01

    Electric vehicles (EVs) are being developed and considered as the future transportation to reduce emission of toxic gas, cost and weight. The battery pack is one of the main crucial parts of the electric vehicle. The power optimization of the battery pack has been maintained by developing a two phase evaporative thermal management system which operation has been controlled by using a wireless battery management system. A large number of individual cells in a battery pack have many wire terminations that are liable for safety failure. To reduce the wiring problem, a wireless battery management system based on ZigBee communication protocol and point-to-point wireless topology has been presented. Microcontrollers and wireless modules are employed to process the information from several sensors (voltage, temperature and SOC) and transmit to the display devices respectively. The WBMS multistage charge balancing system offering more effective and efficient responses for several numbers of series connected battery cells. The concept of double tier switched capacitor converter and resonant switched capacitor converter is used for reducing the charge balancing time of the cells. The balancing result for 2 cells and 16 cells are improved by 15.12% and 25.3% respectively. The balancing results are poised to become better when the battery cells are increased.

  2. Establishing an intelligent transportation systems (ITS) lab at LTRC.

    Science.gov (United States)

    2008-09-30

    The primary goal of this research project is to lay the foundation for establishing a state-of-the-art Intelligent Transportation Systems (ITS) : lab at the Louisiana Transportation Research Center (LTRC), where data will be collected, analyzed, and ...

  3. Modelling the Global Transportation Systems for the Hydrogen Economy

    Energy Technology Data Exchange (ETDEWEB)

    Krzyzanowski, D.A.; Kypreos, S.

    2004-03-01

    A modelling analysis of the transportation system is described, focused on the market penetration of different transportation technologies (including Learning-by-Doing) until the year 2050. A general outline of the work and first preliminary results are presented. (author)

  4. Costs and benefits of MDOT intelligent transportation system deployments.

    Science.gov (United States)

    2015-07-01

    This report analyses costs and benefits of Intelligent Transportation Systems (ITS) deployed by : the Michigan Department of Transportation (MDOT). MDOT ITS focuses on traffic incident : management and also provide Freeway Courtesy Patrol services. A...

  5. Sensor network design for multimodal freight transportation systems.

    Science.gov (United States)

    2009-10-15

    The agricultural and manufacturing industries in the US Midwest region rely heavily on the efficiency of freight transportation systems. While the growth of freight movement far outpaces that of the transportation infrastructure, ensuring the efficie...

  6. Functional requirements for a comprehensive transportation location referencing system

    Science.gov (United States)

    2000-06-01

    Transportation agencies manage data that is referenced in one, two, three, and four dimensions. Location referencing system (LRS) data models vary across transportation agencies and often within organizations as well. This has resulted in failed atte...

  7. Advanced transport systems analysis, modeling, and evaluation of performances

    CERN Document Server

    Janić, Milan

    2014-01-01

    This book provides a systematic analysis, modeling and evaluation of the performance of advanced transport systems. It offers an innovative approach by presenting a multidimensional examination of the performance of advanced transport systems and transport modes, useful for both theoretical and practical purposes. Advanced transport systems for the twenty-first century are characterized by the superiority of one or several of their infrastructural, technical/technological, operational, economic, environmental, social, and policy performances as compared to their conventional counterparts. The advanced transport systems considered include: Bus Rapid Transit (BRT) and Personal Rapid Transit (PRT) systems in urban area(s), electric and fuel cell passenger cars, high speed tilting trains, High Speed Rail (HSR), Trans Rapid Maglev (TRM), Evacuated Tube Transport system (ETT), advanced commercial subsonic and Supersonic Transport Aircraft (STA), conventionally- and Liquid Hydrogen (LH2)-fuelled commercial air trans...

  8. Biking and Walking: The Position of Non-Motorised Transport Modes in Transport Systems

    NARCIS (Netherlands)

    Rietveld, Piet

    2001-01-01

    Long run developments such as income growth and urban sprawl lead one to expect a continuous decline of thecontribution of non-motorised transport modes to the performance of transport systems. In terms of the total number of trips, non-motorised transport modes have retained high shares, however.

  9. Modelling the transport system in China and evaluating the current strategies towards the sustainable transport development

    DEFF Research Database (Denmark)

    Liu, W.; Lund, H.; Mathiesen, B.V.

    2013-01-01

    in China. With this purpose in mind, a Chinese transport model has been created and three current transport strategies which are high speed railway (HSR), urban rail transit (URT) and electric vehicle (EV) were evaluated together with a reference transport system in 2020. As conservative results, 13...

  10. Monju secondary heat transport system sodium leak

    International Nuclear Information System (INIS)

    Suzuki, Takeo; Hiroi, Hiroshi; Usami, Shin; Iwata, Koji.

    1996-01-01

    On December 8, 1995, the sodium leakage from the secondary heat transport system (SHTS) occurred in the piping room of the reactor auxiliary building in Monju. The secondary sodium leaked through a temperature sensor, due to the breakaway of the tip of the well tube of the sensor installed near the outlet of the intermediate heat exchanger (IHX) in the C loop of SHTS. The reactor core remained cooled and thus, from the viewpoint of radiological hazards, the safety of the reactor was secured. There were no adverse effects for operating personnel or the surrounding environment. The cause of the well tube failure is considered to result from high cycle fatigue due to flow induced vibrations. Delay in draining the sodium from the leaking loop increased the consequential effects from sodium combustion products. (author)

  11. The safe road transport system approach

    Directory of Open Access Journals (Sweden)

    Vollpracht Hans-Joachim

    2016-07-01

    Full Text Available More than 1,24 million people die each year on the worlds roads and between 20 to 50 million suffer from nonfatal injuries. The UN Road Safety Collaboration Meetings under the leadership of WHO developed the Programme for the Decade of Actions for road safety taking nations into the responsibility of improving their accident figures by the five pillars of a national Road Safety Policy, safer Roads, safer Vehicles, safer Road Users and Post Crash Care. It is this Safe System Approach that takes into consideration the land use, infrastructure and transport planning, road user’s abilities and limitations and the close cooperation of all governmental and none governmental stakeholders involved.

  12. ASTRA - an automatic system for transport analysis in a tokamak

    International Nuclear Information System (INIS)

    Pereverzev, G.V.; Yushmanov, P.N.; Dnestrovskii, A.Yu.; Polevoi, A.R.; Tarasjan, K.N.; Zakharov, L.E.

    1991-08-01

    The set of codes described here - ASTRA (Automatic System of Transport Analysis) - is a flexible and effective tool for the study of transport mechanisms in reactor-oriented facilities of the tokamak type. Flexibility is provided within the ASTRA system by a wide choice of standard relationships, functions and subroutines representing various transport coefficients, methods of auxiliary heating and other physical processes in the tokamak plasma, as well as by the possibility of pre-setting transport equations and variables for data output in a simple and conseptually transparent form. The transport code produced by the ASTRA system provides an adequate representation of the discharges for present experimental conditions. (orig.)

  13. Histology atlas of the developing mouse hepatobiliary hemolymphatic vascular system with emphasis on embryonic days 11.5-18.5 and early postnatal development

    Science.gov (United States)

    A critical event in fetal development is the proper formation of the vascular system, of which the hepatobiliary system plays a pivotal role. This has lead pathologists and scientists to utilize transgenic mice to identify developmental disorders associated with the hepatobiliary vascular system. Va...

  14. Systemic effects of periodontitis: Lessons learned from research on atherosclerotic vascular disease and adverse pregnancy outcomes

    Science.gov (United States)

    Papapanou, Panos N.

    2015-01-01

    Studies conducted over the past 25 years have focused on the role of periodontitis, an inflammatory condition of microbial etiology that destroys the tooth supporting tissues, as a systemic inflammatory stressor that can act as an independent risk factor of atherosclerotic vascular disease (AVSD) and adverse pregnancy outcomes (APOs). It has been suggested that periodontitis-associated bacteremias and systemic dissemination of inflammatory mediators produced in the periodontal tissues may result in systemic inflammation and endothelial dysfunction, while bacteria of oral origin may translocate into the feto-placental unit. Epidemiologic studies largely support an association between periodontitis and ASVD / APOs independent of known confounders; indeed, periodontitis has been shown to confer statistically significantly elevated risk for clinical events associated with ASVD and APOs in multivariable adjustments. On the other hand, intervention studies demonstrate that although periodontal therapy reduces systemic inflammation and improves endothelial function, it has no positive effect on the incidence of APOs. Studies of the effects of periodontal interventions on ASVD-related clinical events are lacking. This review summarizes key findings from mechanistic, association and intervention studies and attempts to reconcile the seemingly contradictory evidence that originates from different lines of investigation. PMID:26388299

  15. An Agent-Based Approach for a Smart Transport System

    Directory of Open Access Journals (Sweden)

    Cristian PEÑARANDA

    2016-11-01

    Full Text Available This paper presents a proposal for a Smart Transport System which is an application that facilitates the interconnection between people (citizens, tourists and transport providers (Bus, metro, trains, trams, defining the services that everyone can request or offer. The system has been defined as a virtual organization where agents (representing actors of the transport system can enter or leave into the system consuming or offering services. Due to the fact that modern urban public transport is increasingly an important service used by citizens in current cities, the proposed system will improve the use of resources while also ensuring time flexible mobility solutions for citizens.

  16. Numerical Modelling Approaches for Sediment Transport in Sewer Systems

    DEFF Research Database (Denmark)

    Mark, Ole

    A study of the sediment transport processes in sewers has been carried out. Based on this study a mathematical modelling system has been developed to describe the transport processes of sediments and dissolved matter in sewer systems. The modelling system consists of three sub-models which...... constitute the basic modelling system necessary to give a discription of the most dominant physical transport processes concerning particles and dissolved matter in sewer systems: A surface model. An advection-dispersion model. A sediment transport model....

  17. Public acceptance of radioactive waste transportation systems

    International Nuclear Information System (INIS)

    Gablin, K.A.

    1978-01-01

    As the thoughts of the country concentrate on the problems of transportation of waste through high traffic urban areas, the problem of how to deal directly and honestly with the public takes on greater significance in the nuclear industry. Non-technical aspects of the methods of transportation, especially by railroad and highway, enter into the total scheme of moving radioactive waste from both weapon and nuclear power plant sources to final processing and disposal. Factors such as shape, color, size, familiarity, and industrial designing are necessary ingredients that take on equal or more significance that the designing of containers to survive the hypothetical accident conditions of the present, or even of the future. Protective Packaging, Inc. has been a leader in the presentation of containers to the private and public sector of the nuclear industry. The products have undergone very open testing, in public, with both invited and uninvited witnesses. In those experiences, dating back to 1969, the problems of public acceptance will be related between the technical problems and the associated social and political problems that relate to container acceptance by the public in today's world. Proven experience data, relative to the safety of the present day systems will be discussed, as well as methods of improving the image in the future. Review will also be given to the effort by industry to discuss the proven record with parties outside the nuclear industry, i.e., individuals and pressure groups that are diametrically opposed to review the facts relative to safety as opposed to other, but more traditional industries

  18. Maternal exposure to cadmium during gestation perturbs the vascular system of the adult rat offspring

    International Nuclear Information System (INIS)

    Ronco, Ana Maria; Montenegro, Marcela; Castillo, Paula; Urrutia, Manuel; Saez, Daniel; Hirsch, Sandra; Zepeda, Ramiro; Llanos, Miguel N.

    2011-01-01

    Several cardiovascular diseases (CVD) observed in adulthood have been associated with environmental influences during fetal growth. Here, we show that maternal exposure to cadmium, a ubiquitously distributed heavy metal and main component of cigarette smoke is able to induce cardiovascular morpho-functional changes in the offspring at adult age. Heart morphology and vascular reactivity were evaluated in the adult offspring of rats exposed to 30 ppm of cadmium during pregnancy. Echocardiographic examination shows altered heart morphology characterized by a concentric left ventricular hypertrophy. Also, we observed a reduced endothelium-dependent reactivity in isolated aortic rings of adult offspring, while endothelium-independent reactivity remained unaltered. These effects were associated with an increase of hem-oxygenase 1 (HO-1) expression in the aortas of adult offspring. The expression of HO-1 was higher in females than males, a finding likely related to the sex-dependent expression of the vascular cell adhesion molecule 1 (VCAM-1), which was lower in the adult female. All these long-term consequences were observed along with normal birth weights and absence of detectable levels of cadmium in fetal and adult tissues of the offspring. In placental tissues however, cadmium levels were detected and correlated with increased NF-κB expression - a transcription factor sensitive to inflammation and oxidative stress - suggesting a placentary mechanism that affect genes related to the development of the cardiovascular system. Our results provide, for the first time, direct experimental evidence supporting that exposure to cadmium during pregnancy reprograms cardiovascular development of the offspring which in turn may conduce to a long term increased risk of CVD.

  19. Characterization of vascular lesions in pigs affected by porcine circovirus type 2-systemic disease.

    Science.gov (United States)

    Resendes, A R; Segalés, J

    2015-05-01

    Vascular lesions and their association with porcine circovirus type 2 (PCV2) were evaluated in multiple organs from 10 pigs affected with PCV2-systemic disease (PCV2-SD). Animals had vascular lesions in multiple organs, consisting of lymphohistiocytic lymphangitis and/or phlebitis, mild to severe necrotizing arteritis, and thrombosis within splenic arterioles and choroid plexus capillaries. Variable amounts of PCV2 nucleic acid detected by in situ hybridization were present within endothelial cells, tunica media myocytes, and perivascular and/or intralesional inflammatory cell infiltrates. PCV2 nucleic acid was detected within endothelial cells of both lymphatic and blood vessels without lesions in the associated tissues. Necrotizing arteritis was principally present in lymph nodes and kidney and consisted of degeneration, necrosis, and pyknosis of myocytes, often with intracytoplasmic, brightly eosinophilic inclusion bodies that were strongly positive for PCV2 nucleic acid. Segmental or circumferential fibrinoid necrosis was mainly present in vessels of the lymph node, spleen, and choroid plexus and was variably associated with PCV2 nucleic acid. Severe lymphangitis associated with strong intralesional PCV2 labeling was frequently detected within the mesenteric and mediastinal lymph nodes and the lamina propria of the ileum. In most tissues, medium and large lymphatics and/or veins often had disruption of the intima and mild mononuclear inflammatory cell infiltration that was variably associated with PCV2 nucleic acid. The present study indicates that vasculitis is a frequent finding in natural cases of PCV2-SD and that PCV2 may have a direct cytopathic effect on tunica media myocytes of small- and medium-sized arteries as well as endothelium. © The Author(s) 2014.

  20. Education in Transportation Systems Planning: Highway Research Record No. 462.

    Science.gov (United States)

    National Academy of Sciences - National Research Council, Washington, DC. Transportation Research Board.

    The papers contained in the issue of Highway Research Record focus on current and emerging patterns of education and training related to transportation systems planning. The five papers are: Transportation Centers and Other Mechanisms to Encourage Interdisciplinary Research and Training Efforts in Transportation (Frederick J. Wegmann and Edward A.…

  1. 78 FR 16030 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-03-13

    ... DEPARTMENT OF TRANSPORTATION Intelligent Transportation Systems Program Advisory Committee; Notice.... Department of Transportation. ACTION: Notice. The Intelligent Transportation Systems (ITS) Program Advisory... Transportation on all matters relating to the study, development, and implementation of intelligent...

  2. The SIMPSONS project: An integrated Mars transportation system

    Science.gov (United States)

    Kaplan, Matthew; Carlson, Eric; Bradfute, Sherie; Allen, Kent; Duvergne, Francois; Hernandez, Bert; Le, David; Nguyen, Quan; Thornhill, Brett

    In response to the Request for Proposal (RFP) for an integrated transportation system network for an advanced Martian base, Frontier Transportation Systems (FTS) presents the results of the SIMPSONS project (Systems Integration for Mars Planetary Surface Operations Networks). The following topics are included: the project background, vehicle design, future work, conclusions, management status, and cost breakdown. The project focuses solely on the surface-to-surface transportation at an advanced Martian base.

  3. Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system

    NARCIS (Netherlands)

    Fiore, Roberto; Rahim, Belquis; Christoffels, Vincent M.; Moorman, Antoon F. M.; Püschel, Andreas W.

    2005-01-01

    The semaphorins are a large family of proteins involved in the patterning of both the vascular and the nervous systems. In order to analyze the function of the membrane-bound semaphorin 5A (Sema5A), we generated mice homozygous for a null mutation in the Sema5a gene. Homozygous null mutants die

  4. Mixed-μ magnetic levitation for advanced ground transport system

    International Nuclear Information System (INIS)

    Russell, F.M.

    1977-12-01

    The possibility of applying the mixed-μ principle for magnetic levitation to ground transport systems is examined. The system is developed specifically for suspension and useful lift to passive weight ratios exceeding 8:1 have been calculated. Application to a hybrid system where conventional wheel drive is used in conjunction with magnetic levitation is explained for urban transport. (author)

  5. Environmental analyses of land transportation systems in The Netherlands

    NARCIS (Netherlands)

    Bouwman, Mirjan E.; Moll, Henri C.

    Environmental analyses of the impact of transportation systems on the environment from the cradle to the grave are rare. This article makes a comparison of various Dutch passenger transportation systems by studying their complete life-cycle energy use. Moreover, systems are compared according to

  6. Anti-Annexin V Antibodies: Association with Vascular Involvement and Disease Outcome in Patients with Systemic Sclerosis

    Directory of Open Access Journals (Sweden)

    Iman A. Hassan

    2010-04-01

    Full Text Available Background: Systemic Sclerosis (SSc is characterized by skin thickening, fibrosis and vascular obliteration. The onset and course are heterogeneous. Prominent features include autoimmunity, inflammation and vascular damage. Aim of study: To measure the level of serum Anti-Annexin V antibodies in SSc patients and to study its significance in relation to vascular damage in these patients. Patients and methods: Twenty patients with SSc (12 with diffuse SSc and 8 with the limited form and 10 healthy age and sex matched volunteers as controls were all subjected to routine laboratory testing and immunological profiling including antinuclear, anti-Scl-70, anticentomere, anticardiolipin antibodies and anti-annexin V antibodies titres. Vascular damage was assessed by clinical examination and assessment of the disease activity score, nailfold capillaroscopy and colour flow Doppler of the renal arteries; Doppler echocardiography was used for assessing pulmonary hypertension. Results: Anti-annexin V antibodies were detected in 75% of patients. Comparisons between anti-annexin V in diffuse and limited subgroups showed no significance; however a statistically significant positive correlation was found between Anti-annexin V titre and the degree of vascular damage in SSc patients. Anti-annexin V increased significantly in patients with severe vascular damage in comparison with those less affected (15.3 ± 6.6 vs. 11.25 ± 3.6, P , 0.05. A significant positive correlation was found between Anti-annexin V titre and both the ACL titre (r = 0.79, P , 0.001 and the resistive index of the main renal artery (r = 0.42, P , 0.05. Conclusion: Anti-annexin V antibodies were significantly present in sera of patients with SSc. Patients with more severe forms of vascular damage had higher titres of these antibodies. Anti-annexin V antibodies are a sensitive predictor of vascular damage in SSc and could serve as a useful parameter in discriminating patients with a higher

  7. Anti-Annexin V Antibodies: Association with Vascular Involvement and Disease Outcome in Patients with Systemic Sclerosis

    Directory of Open Access Journals (Sweden)

    Reem A. Habeeb

    2010-01-01

    Full Text Available Background Systemic Sclerosis (SSc is characterized by skin thickening, fibrosis and vascular obliteration. The onset and course are heterogeneous. Prominent features include autoimmunity, inflammation and vascular damage. Aim of Study To measure the level of serum Anti-Annexin V antibodies in SSc patients and to study its significance in relation to vascular damage in these patients. Patients and Methods Twenty patients with SSc (12 with diffuse SSc and 8 with the limited form and 10 healthy age and sex matched volunteers as controls were all subjected to routine laboratory testing and immunological profiling including antinuclear, anti-Scl-70, anticentomere, anticardiolipin antibodies and anti-annexin V antibodies titres. Vascular damage was assessed by clinical examination and assessment of the disease activity score, nailfold capillaroscopy and colour flow Doppler of the renal arteries; Doppler echocardiography was used for assessing pulmonary hypertension. Results Anti-annexin V antibodies were detected in 75% of patients. Comparisons between anti-annexin V in diffuse and limited subgroups showed no significance; however a statistically significant positive correlation was found between Anti-annexin V titre and the degree of vascular damage in SSc patients. Anti-annexin V increased significantly in patients with severe vascular damage in comparison with those less affected (15.3 ± 6.6 vs. 11.25 ± 3.6, P < 0.05. A significant positive correlation was found between Anti-annexin V titre and both the ACL titre (r = 0.79, P < 0.001 and the resistive index of the main renal artery (r = 0.42, P < 0.05. Conclusion Anti-annexin V antibodies were significantly present in sera of patients with SSc. Patients with more severe forms of vascular damage had higher titres of these antibodies. Anti-annexin V antibodies are a sensitive predictor of vascular damage in SSc and could serve as a useful parameter in discriminating patients with a higher risk of

  8. Transportation system requirements document. Revision 1 DCN01. Supplement

    International Nuclear Information System (INIS)

    1995-05-01

    The original Transportation System Requirements Document described the functions to be performed by and the technical requirements for the Transportation System to transport spent nuclear fuel (SNF) and high-level radioactive waste (HLW) from Purchaser and Producer sites to a Civilian Radioactive Waste Management System (CRWMS) site, and between CRWMS sites. The purpose of that document was to define the system-level requirements. These requirements include design and operations requirements to the extent they impact on the development of the physical segments of Transportation. The document also presented an overall description of Transportation, its functions, its segments, and the requirements allocated to the segments and the system-level interfaces with Transportation. This revision of the document contains only the pages that have been modified

  9. The Exchange Value Embedded in a Transport System

    International Nuclear Information System (INIS)

    Xia Qinglan; Xu Shaofeng

    2010-01-01

    This paper shows that a well designed transport system has an embedded exchange value by serving as a market for potential exchange between consumers. Under suitable conditions, one can improve the welfare of consumers in the system simply by allowing some exchange of goods between consumers during transportation without incurring additional transportation cost. We propose an explicit valuation formula to measure this exchange value for a given compatible transport system. This value is always nonnegative and bounded from above. Criteria based on transport structures, preferences and prices are provided to determine the existence of a positive exchange value. Finally, we study a new optimal transport problem with an objective taking into account of both transportation cost and exchange value.

  10. Stochasticity and transport in Hamiltonian systems

    International Nuclear Information System (INIS)

    MacKay, R.S.; Meiss, J.D.; Percival, I.C.

    1984-01-01

    The theory of transport in nonlinear dynamics is developed in terms of ''leaky'' barriers which remain when invariant tori are destroyed. A critical exponent for transport times across destroyed tori is obtained which explains numerical results of Chirikov. The combined effects of many destroyed tori lead to power-law decay of correlations observed in many computations. (author)

  11. Indicator system for the environmental assessment of energy transport systems

    International Nuclear Information System (INIS)

    Knoepfel, I.

    1995-01-01

    The aim of this dissertation is to define a consistent set of indicators for the environmental assessment of different energy transport systems: high-voltage alternating and direct current transmission lines, electric cables, pipelines for gas and oil, inland waterway, road and rail transportation, according to state-of-the-art technologies. The indicator system is used for comparative analysis and identification of environmental hot-spots of the different systems. The environmental performance of power plants close to production or unloading terminals with subsequent power transmission and the transport of fossil fuels with power production close to the end-users is compared. Quantitative indicators are defined for different impact categories: fossil energy depletion, impacts from emissions, land use, noise impacts and visibility. A further aggregation of the different indicators to obtain a universal environmental score was not envisaged. It was not possible to define a quantitative indicator for possible electric and magnetic field effects because of insufficient knowledge of the involved dose-response metrics. The proposed indicators quantify dose-response relationships also below emission or immission limits imposed by law, which was one of the main requirements in this work. By reducing all information to an equivalent impacted area, a high level of consistency was achieved for land use, noise impacts and visibility indicators. Other indicators refer to the energy content of fossil resources and to equivalent emissions of reference substances. The calculation of an equivalent impacted area was not considered an efficient approach in these cases. The performance of the proposed indicator system and its applicability to infrastructure and regional planning is tested in two practical examples. (author) figs., tabs., refs

  12. Sustainable Transport in Romania vs. European Union. Analysis of Road Transport System from the Sustainable Transport Perspective

    Directory of Open Access Journals (Sweden)

    Clitan Andrei - Florin

    2014-12-01

    Full Text Available Sustainability is a term used more often lately, based on three factors: social, economic, and environmental. Sustainable transport systems increase social cohesion, reduce environmental problems and help create a more efficient economy. Sustainable transport consists in a complex system that is designed to ensure mobility needs of present generations without damaging the environment and health factors. By improving energy and material consumption, it must be capable to satisfy in optimum conditions the need for mobility for future generations. The current transportation system has not a character of sustainability.

  13. INFORMATION SYSTEMS APPLIED TO TRANSPORT IMPROVEMENT

    Directory of Open Access Journals (Sweden)

    JULIAN ANDRES ZAPATA CORTES

    2013-01-01

    Full Text Available El transporte es uno de los elementos más relevantes para la competitividad de las empresas y las ciudades, pues un sistema de transporte inadecuado genera altos costos y bajos niveles de servicio al cliente, lo que fi nalmente produce un impacto económico para ambas partes. Este artículo presenta una revisión de herramientas tecnológicas que hacen parte de los sistemas de transporte inteligentes (ITS, sistemas utilizados para el mejoramiento del desempeño y seguridad del transporte, no solo de carga sino también de pasajeros y en diferentes modos. El artículo comienza con una descripción sobre los sistemas de transporte ITS, seguido por la presentación de los benefi cios de estos sistemas y fi nalmente se realiza una revisión de las diferentes herramientas que enmarcan los ITS.

  14. Modelling the transport system in China and evaluating the current strategies towards the sustainable transport development

    International Nuclear Information System (INIS)

    Liu, Wen; Lund, Henrik; Mathiesen, Brian Vad

    2013-01-01

    Transport is one of the most challenge sectors when addressing energy security and climate change due to its high reliance on oil products and lack of the alternative fuels. This paper explores the ability of three transport strategies to contribute to the development of a sustainable transport in China. With this purpose in mind, a Chinese transport model has been created and three current transport strategies which are high speed railway (HSR), urban rail transit (URT) and electric vehicle (EV) were evaluated together with a reference transport system in 2020. As conservative results, 13% of the energy saving and 12% of the CO 2 emission reduction can be attained by accomplishing three strategies compared with the reference transport system. However, the energy demand of transport in 2020 with the implementation of three strategies will be about 1.7 times as much as today. The three strategies show the potential of drawing the transport demand to the more energy efficient vehicles; however, more initiatives are needed if the sustainable transport is the long term objective, such as the solutions to stabilise the private vehicle demands, to continuously improve the vehicle efficiency and to boost the alternative fuels produced from the renewable energy sources. - Highlights: • A Chinese transport model was created and three transport strategies were evaluated • Transport is the biggest driver of the oil demand in China not the industry • The energy demand of transport in 2020 will be twice as much as today • Strategies contribute 13% energy saving and 12% CO 2 emission reduction • More initiatives are needed if a sustainable transport is the long-term objective

  15. Vascular Cell Induction Culture System Using Arabidopsis Leaves (VISUAL) Reveals the Sequential Differentiation of Sieve Element-Like Cells.

    Science.gov (United States)

    Kondo, Yuki; Nurani, Alif Meem; Saito, Chieko; Ichihashi, Yasunori; Saito, Masato; Yamazaki, Kyoko; Mitsuda, Nobutaka; Ohme-Takagi, Masaru; Fukuda, Hiroo

    2016-06-01

    Cell differentiation is a complex process involving multiple steps, from initial cell fate specification to final differentiation. Procambial/cambial cells, which act as vascular stem cells, differentiate into both xylem and phloem cells during vascular development. Recent studies have identified regulatory cascades for xylem differentiation. However, the molecular mechanism underlying phloem differentiation is largely unexplored due to technical challenges. Here, we established an ectopic induction system for phloem differentiation named Vascular Cell Induction Culture System Using Arabidopsis Leaves (VISUAL). Our results verified similarities between VISUAL-induced Arabidopsis thaliana phloem cells and in vivo sieve elements. We performed network analysis using transcriptome data with VISUAL to dissect the processes underlying phloem differentiation, eventually identifying a factor involved in the regulation of the master transcription factor gene APL Thus, our culture system opens up new avenues not only for genetic studies of phloem differentiation, but also for future investigations of multidirectional differentiation from vascular stem cells. © 2016 American Society of Plant Biologists. All rights reserved.

  16. Data security in Intelligent Transport Systems

    Directory of Open Access Journals (Sweden)

    Tomas Zelinka

    2012-10-01

    Full Text Available Intelligent Transport Services expect availability of the secure seamless communications solutions typically covering widely spread areas. Different ITS solutions require different portfolio of telecommunications service quality. These parameters have to correspond with ITS service performance parameters required by specific service. Even though quite extensive range of public wireless data services with reasonable coverage are provided, most of them are provided with no guaranteed quality and security. ITS requirements can be in most parameters easier reached if multi-path communications systems are applied core solution is combined with both public as well as private ones where and when it is needed. Such solution requires implementation of relevant flexible system architecture supported by the efficient decision processes. This paper is concentrated the telecommunications security issues relevant to the ITS wide area networking. Expected level of security varies in dependence on relevant ITS service requirements. Data volumes transferred both in private data vehicle on board networks as well as between vehicles and infrastructure (C2I or other vehicles (C2C progressively grow. Such trend upsurges the fatal problems appearance probability in case security of the wide area networks is not relevantly treated. That is reason why relevant communications security treatment becomes crucial part of the ITS solution. Besides of available "off shelf" security tools we present solution based on non-public universal identifier with dynamical extension (time and position dependency as an autonomous variables and data selection according to actor role or category. Presented results were obtained within projects e-Ident1, DOTEK2 and SRATVU3.

  17. Effects of heavy ion radiation on the brain vascular system and embryonic development

    Science.gov (United States)

    Yang, T. C.; Tobias, C. A.

    Using neonatal rats as a model system, we investigated the response of the brain vascular system to ionizing radiation and found that distinct petechial hemorrages developed in the cerebral cortex within a few hours after irradiation, reached a maximum about 13 to 24 hours, and decreased exponentially with time. No brain hemorrhage was found in neonatal rats 12 days after irradiation. Our experimental results indicate that a dose of a few hundred rad of X rays can induce a significant number of hemorrhages in the brain, and the number of lesions increases exponentially with dose. Heavy ions induce more hemorrhages than X rays for a given dose, and the RBE for 670 MeV/u neon particles ranges from about 2.0 for low doses to about 1.4 for high doses. A histological study on the hemorrhages indicates that a large number of red blood cells leak from the blood vessels. The radiation-induced hemorrhages may be a result of some capillary membrane damages or reproductive death of some blood vessel epithelial cells. The fast onset of hemorrhage after irradiation suggests that some membrane damage may be involved. The effect of heavy-ion radiation on the embryonic development was studied with energetic iron particles. Pregnant mice were whole-body irradiated with 600 MeV/u iron particles on day 6 of gestation and were sacrificed 12 days after irradiation. Various physical abnormalities were observed, and embryos irradiated with 1 rad iron particles showed retardation of body development.

  18. Amplatzer Vascular Plug Anchoring Technique to Stabilize the Delivery System for Microcoil Embolization

    International Nuclear Information System (INIS)

    Onozawa, Shiro; Murata, Satoru; Mine, Takahiko; Sugihara, Fumie; Yasui, Daisuke; Kumita, Shin-ichiro

    2016-01-01

    PurposeTo evaluate the feasibility of a novel embolization technique, the Amplatzer vascular plug (AVP) anchoring technique, to stabilize the delivery system for microcoil embolization.Materials and methodsThree patients were enrolled in this study, including two cases of internal iliac artery aneurysms and one case of internal iliac arterial occlusion prior to endovascular aortic repair. An AVP was used in each case for embolization of one target artery, and the AVP was left in place. The AVP detachment wire was then used as an anchor to stabilize the delivery system for microcoil embolization to embolize the second target artery adjacent to the first target artery. The microcatheter for the microcoils was inserted parallel to the AVP detachment wire in the guiding sheath or catheter used for the AVP.ResultsThe AVP anchoring technique was achieved and the microcatheter was easily advanced to the second target artery in all three cases.ConclusionThe AVP anchoring technique was found to be feasible to advance the microcatheter into the neighboring artery of an AVP-embolized artery.

  19. Primo Vascular System in the Subarachnoid Space of a Mouse Brain

    Directory of Open Access Journals (Sweden)

    Sang-Ho Moon

    2013-01-01

    Full Text Available Objective. Recently, a novel circulatory system, the primo vascular system (PVS, was found in the brain ventricles and in the central canal of the spinal cord of a rat. The aim of the current work is to detect the PVS along the transverse sinuses between the cerebrum and the cerebellum of a mouse brain. Materials and Methods. The PVS in the subarachnoid space was analyzed after staining with 4',6-diamidino-2-phenylindole (DAPI and phalloidin in order to identify the PVS. With confocal microscopy and polarization microscopy, the primo vessel underneath the sagittal sinus was examined. The primo nodes under the transversal sinuses were observed after peeling off the dura and pia maters of the brain. Results. The primo vessel underneath the superior sagittal sinus was observed and showed linear optical polarization, similarly to the rabbit and the rat cases. The primo nodes were observed under the left and the right transverse sinuses at distances of 3,763 μm and 5,967 μm. The average size was 155 μm × 248 μm. Conclusion. The observation of primo vessels was consistent with previous observations in rabbits and rats, and primo nodes under the transverse sinuses were observed for the first time in this work.

  20. Geographic information systems - transportation ISTEA management systems server net prototype pooled fund study : phase B - summary

    Science.gov (United States)

    1997-06-01

    The Geographic Information System-Transportation (GIS-T) ISTEA Management Systems Server Net Prototype Pooled Fund Study represents the first national cooperative effort in the transportation industry to address the management and monitoring systems ...

  1. Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction.

    Science.gov (United States)

    Estrada-Gutierrez, Guadalupe; Cappello, Renato E; Mishra, Nikita; Romero, Roberto; Strauss, Jerome F; Walsh, Scott W

    2011-01-01

    This study was conducted to determine the following: (1) whether matrix metalloproteinase-1 (MMP-1) is increased in systemic vessels of preeclamptic women, (2) whether this increase might be mediated by neutrophils, and (3) whether MMP-1 could be responsible for vascular dysfunction. Omental arteries and plasma were collected from healthy pregnant and preeclamptic women. Omental arteries were evaluated for gene and protein expression of MMP-1, collagen type 1α, tissue inhibitor of metalloproteinase-1, and vascular reactivity to MMP-1. Gene and protein expression levels were also evaluated in human vascular smooth muscle cells (VSMCs) co-cultured with activated neutrophils, reactive oxygen species, or tumor necrosis factor α. Vessel expression of MMP-1 and circulating MMP-1 levels were increased in preeclamptic women, whereas vascular expression of collagen or tissue inhibitor of metalloproteinase-1 were down-regulated or unchanged. In cultured VSMCs, the imbalance in collagen-regulating genes of preeclamptic vessels was reproduced by treatment with neutrophils, tumor necrosis factor α, or reactive oxygen species. Chemotaxis studies with cultured cells revealed that MMP-1 promoted recruitment of neutrophils via vascular smooth muscle release of interleukin-8. Furthermore, MMP-1 induced vasoconstriction via protease-activated receptor-1, whose expression was significantly increased in omental arteries of preeclamptic women and in VSMCs co-cultured with neutrophils. Collectively, these findings disclose a novel role for MMP-1 as a mediator of vasoconstriction and vascular dysfunction in preeclampsia. Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  2. Glucose transporter distribution in the vessels of the central nervous system of the axolotl Ambystoma mexicanum (Urodela: Ambystomatidae).

    Science.gov (United States)

    Lazzari, Maurizio; Bettini, Simone; Ciani, Franco; Franceschini, Valeria

    2008-10-01

    The GLUT-1 isoform of the glucose transporter is commonly considered a reliable molecular marker of blood-brain barrier endothelia in the neural vasculature organized in a three-dimensional network of single vessels. The central nervous system of the axolotl Ambystoma mexicanum is characterized by a vascular architecture that contains both single and paired vessels. The presence and distribution of the GLUT-1 transporter are studied in this urodele using both immunoperoxidase histochemistry and immunogold technique. Light microscopy reveals immunopositivity in both parenchymal and meningeal vessels. The transverse-sectioned pairs of vessels do not show the same size. Furthermore, in the same pair, the two elements often differ in diameter. The main regions of the central nervous system show a different percentage of the paired structures. Only immunogold cytochemistry reveals different staining intensity in the two adjoined elements of a vascular pair. Colloidal gold particles show an asymmetric distribution in the endothelia of both single and paired vessels. These particles are more numerous on the abluminal surface than on the luminal one. The particle density is calculated in both vascular types. The different values could indicate functional differences between single and paired vessels and between the two adjoined elements of a pair, regarding glucose transport.

  3. Intelligent transportation system (ITS) international research exchange.

    Science.gov (United States)

    2014-01-01

    ITS applications address surface transportation challenges in safety, mobility, and : sustainability that are similar in cause and impact worldwide. International ITS : exchange allows cooperating nations to benefit from each others pre-competitiv...

  4. Dwight David Eisenhower Transportation Fellowship Program System -

    Data.gov (United States)

    Department of Transportation — DDETFP is a web-based application used to measure the performance of the DDETFP program, enhance reporting, and evaluate the programs' effectiveness in meeting goals...

  5. Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study

    Directory of Open Access Journals (Sweden)

    Blacker David

    2010-10-01

    Full Text Available Abstract Background Acute ischaemic stroke is associated with alteration in systemic markers of vascular function. We measured forearm vascular function (using forearm flow mediated dilatation to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function. Methods Prospective case control study enrolling 17 patients with recent acute ischaemic stroke/TIA and 17 sex matched controls with stroke more than two years previously. Forearm vascular function was measured using flow medicated dilatation (FMD. Results Flow mediated dilatation was 6.0 ± 1.1% in acute stroke/TIA patients and 4.7 ± 1.0% among control subjects (p = 0.18. The mean paired difference in FMD between subjects with recent acute stroke and controls was 1.25% (95% CI -0.65, 3.14; p = 0.18. Endothelium independent dilatation was measured in six pairs of participants and was similar in acute stroke/TIA patients (22.6 ± 4.3% and control subjects (19.1 ± 2.6%; p = 0.43. Conclusions Despite the small size of this study, these data indicate that recent acute stroke is not necessarily associated with a clinically important reduction in FMD.

  6. 2015 International Conference on Information Technology and Intelligent Transportation Systems

    CERN Document Server

    Jain, Lakhmi; Zhao, Xiangmo

    2017-01-01

    This volume includes the proceedings of the 2015 International Conference on Information Technology and Intelligent Transportation Systems (ITITS 2015) which was held in Xi’an on December 12-13, 2015. The conference provided a platform for all professionals and researchers from industry and academia to present and discuss recent advances in the field of Information Technology and Intelligent Transportation Systems. The presented information technologies are connected to intelligent transportation systems including wireless communication, computational technologies, floating car data/floating cellular data, sensing technologies, and video vehicle detection. The articles focusing on intelligent transport systems vary in the technologies applied, from basic management systems to more application systems including topics such as emergency vehicle notification systems, automatic road enforcement, collision avoidance systems and some cooperative systems. The conference hosted 12 invited speakers and over 200 part...

  7. Microvascular dysfunction with increased vascular leakage response in mice systemically exposed to arsenic.

    Science.gov (United States)

    Chen, Shih-Chieh; Huang, Shin-Yin; Lu, Chi-Yu; Hsu, Ya-Hung; Wang, Dean-Chuan

    2014-09-01

    The mechanisms underlying cardiovascular disease induced by arsenic exposure are not completely understood. The objectives of this study were to investigate whether arsenic-fed mice have an increased vascular leakage response to vasoactive agents and whether enhanced type-2 protein phosphatase (PP2A) activity is involved in mustard oil-induced leakage. ICR mice were fed water or sodium arsenite (20 mg/kg) for 4 or 8 weeks. The leakage response to vasoactive agents was quantified using the Evans blue (EB) technique or vascular labeling with carbon particles. Increased EB leakage and high density of carbon-labeled microvessels were detected in arsenic-fed mice treated with mustard oil. Histamine induced significantly higher vascular leakage in arsenic-fed mice than in water-fed mice. Pretreatment with the PP2A inhibitor okadaic acid or the neurokinin 1 receptor (NK1R) blocker RP67580 significantly reduced mustard oil-induced vascular leakage in arsenic-fed mice. The protein levels of PP2Ac and NK1R were similar in both groups. PP2A activity was significantly higher in the arsenic-fed mice compared with the control group. These findings indicate that microvessels generally respond to vasoactive agents, and that the increased PP2A activity is involved in mustard oil-induced vascular leakage in arsenic-fed mice. Arsenic may initiate endothelial dysfunction, resulting in vascular leakage in response to vasoactive agents.

  8. Capacity analysis of an automated kit transportation system

    NARCIS (Netherlands)

    Zijm, W.H.M.; Adan, I.J.B.F.; Buitenhek, R.; Houtum, van G.J.J.A.N.

    2000-01-01

    In this paper, we present a capacity analysis of an automated transportation system in a flexible assembly factory. The transportation system, together with the workstations, is modeled as a network of queues with multiple job classes. Due to its complex nature, the steadystate behavior of this

  9. Urban Transportation Systems in Bogotá and Copenhagen

    DEFF Research Database (Denmark)

    Pineda, Andres Felipe Valderrama; Jørgensen, Ulrik

    2008-01-01

    In this paper we explore the socio-technical dynamics of developing new urban transport systems. Based on the analysis of empirical material from the study of the Transmilenio in Bogotá and the Metro in Copenhagen, we propose that the design, construction and operation of urban transport systems...

  10. Markets and system developments in rail-guided passenger transport

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Guenter [DB International GmbH, Karlsruhe (Germany); Grein, Ottmar [DB International GmbH, Frankfurt am Main (Germany)

    2013-03-01

    The way people are transported is an ever-changing process - and that applies to the railway systems too. If anything, this process of change has sped up in recent years. The authors of this report present an overview of the markets for rail-guided forms of transport and the various systems that exist. (orig.)

  11. Transport Coefficients for dense hard-disk systems

    NARCIS (Netherlands)

    Garcia-Rojo, R.; Luding, Stefan; Brey, J. Javier; Ooms, G.; Hoogendoorn, C.J.

    2007-01-01

    A study of the transport coefficients of a system of elastic hard disks, based on the use of Helfand-Einstein expressions is reported. The pressure, the viscosity, and the heat conductivity are examined for different density and system-size. While most transport coefficients agree with Enskog theory

  12. An intelligent support system for automatic detection of cerebral vascular accidents from brain CT images.

    Science.gov (United States)

    Hajimani, Elmira; Ruano, M G; Ruano, A E

    2017-07-01

    This paper presents a Radial Basis Functions Neural Network (RBFNN) based detection system, for automatic identification of Cerebral Vascular Accidents (CVA) through analysis of Computed Tomographic (CT) images. For the design of a neural network classifier, a Multi Objective Genetic Algorithm (MOGA) framework is used to determine the architecture of the classifier, its corresponding parameters and input features by maximizing the classification precision, while ensuring generalization. This approach considers a large number of input features, comprising first and second order pixel intensity statistics, as well as symmetry/asymmetry information with respect to the ideal mid-sagittal line. Values of specificity of 98% and sensitivity of 98% were obtained, at pixel level, by an ensemble of non-dominated models generated by MOGA, in a set of 150 CT slices (1,867,602pixels), marked by a NeuroRadiologist. This approach also compares favorably at a lesion level with three other published solutions, in terms of specificity (86% compared with 84%), degree of coincidence of marked lesions (89% compared with 77%) and classification accuracy rate (96% compared with 88%). Copyright © 2017. Published by Elsevier B.V.

  13. Advanced transportation system study: Manned launch vehicle concepts for two way transportation system payloads to LEO

    Science.gov (United States)

    Duffy, James B.

    1993-01-01

    The purpose of the Advanced Transportation System Study (ATSS) task area 1 study effort is to examine manned launch vehicle booster concepts and two-way cargo transfer and return vehicle concepts to determine which of the many proposed concepts best meets NASA's needs for two-way transportation to low earth orbit. The study identified specific configurations of the normally unmanned, expendable launch vehicles (such as the National Launch System family) necessary to fly manned payloads. These launch vehicle configurations were then analyzed to determine the integrated booster/spacecraft performance, operations, reliability, and cost characteristics for the payload delivery and return mission. Design impacts to the expendable launch vehicles which would be required to perform the manned payload delivery mission were also identified. These impacts included the implications of applying NASA's man-rating requirements, as well as any mission or payload unique impacts. The booster concepts evaluated included the National Launch System (NLS) family of expendable vehicles and several variations of the NLS reference configurations to deliver larger manned payload concepts (such as the crew logistics vehicle (CLV) proposed by NASA JSC). Advanced, clean sheet concepts such as an F-1A engine derived liquid rocket booster (LRB), the single stage to orbit rocket, and a NASP-derived aerospace plane were also included in the study effort. Existing expendable launch vehicles such as the Titan 4, Ariane 5, Energia, and Proton were also examined. Although several manned payload concepts were considered in the analyses, the reference manned payload was the NASA Langley Research Center's HL-20 version of the personnel launch system (PLS). A scaled up version of the PLS for combined crew/cargo delivery capability, the HL-42 configuration, was also included in the analyses of cargo transfer and return vehicle (CTRV) booster concepts. In addition to strictly manned payloads, two-way cargo

  14. Aspects of transport system management within mining complex using information and telecommunication systems

    Science.gov (United States)

    Semykina, A. S.; Zagorodniy, N. A.; Konev, A. A.; Duganova, E. V.

    2018-05-01

    The paper considers aspects of transport system management within the mining complex. It indicates information and telecommunication systems that are used to increase transportation efficiency. It also describes key advantages and disadvantages. It is found that software products of the Modular Company used in pits allow increasing transport performance, minimizing losses and ensuring efficient transportation of minerals.

  15. Vascular endothelial growth factor in systemic lupus erythematosus - correlations with disease activity and nailfold capillaroscopy changes.

    Science.gov (United States)

    Bărbulescu, Andreea Lili; Vreju, Ananu Florentin; Bugă, Ana Maria; Sandu, Raluca Elena; Criveanu, Cristina; Tudoraşcu, Diana Rodica; Gheonea, Ioana Andreea; Ciurea, Paulina Lucia

    2015-01-01

    Our study aimed to quantify serum VEGF (vascular endothelial growth factor) and its inter-relation with the severity of microvascular damage, assessed by nailfold capillaroscopy (NC), and to establish the possible relationship with disease activity score. We included 18 patients, diagnosed with systemic lupus erythematosus (SLE) and 17 gender and age-matched control subjects. For determining serum VEGF, we used a Human VEGF Assay kit-IBL. NC was performed, according to the standard method, using a video-capillaroscope Videocap 3.0, DS Medica, by the same examiner, blinded to clinical and laboratory data. Serum VEGF registered a mean value of 68.99±71.06 pg/mL for SLE patients and 31.84±11.74 pg/mL for controls, differences statistically significant; depending on disease activity, we found a mean value of 60.11±57.74 pg/mL, for patients with moderate disease activity vs. 30.96±11.51 pg/mL for the ones with a low activity (p=0.014). We found a moderately positive correlation, statistically significant (p=0.015), between serum level of VEGF and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Performing NC, we found changes in 88.88% of the patients; the most frequent were increased tortuosity, dilated capillaries, an increased length and a prominent subpapillary plexus. The presence of nailfold capillaroscopy changes and serum level of VEGF, correlated moderately, positive. Since serum levels of VEGF are higher in SLE patients, compared to controls, significantly different according to disease activity degree, and directly inter-related to abnormal NC patterns and a more active disease, we can include these accessible parameters in the routine evaluation, in order to better quantify the systemic damage, individualize the treatment, improve the outcome and life quality for these patients.

  16. The transnational territorial transport system of the Baltic Region

    Directory of Open Access Journals (Sweden)

    Gumenyuk Ivan

    2012-03-01

    Full Text Available In this paper we focus on the structure and territorial borders of the Baltic Sea region, and examine the key structural elements of the transnational territorial transport system. In this respect, we clarify some terms used in transport geography. For the first time the transport system gets territorially localized, which allows for a broad range of new studies of transnational transportation in the Baltic Sea area. We also identify the main principles of development and operation of international territorial transport systems and present them taking the Baltic Sea region as an example. Our findings, we hope, will have a great practical application for researchers of transport geography, especially those studying international logistics.

  17. Internal transport barrier physics in helical systems

    International Nuclear Information System (INIS)

    Yokoyama, M.; Minami, T.; Fujisawa, A.; Herranz, J.; Ida, K.; Yamagishi, O.; Yamada, H.; Maaberg, H.; Beidler, C.D.; Dinklage, A.; Estrada, T.; Castejon, F.; Murakami, S.

    2005-01-01

    The electron internal transport barrier (eITB) has been observed in wide range of helical systems, such as CHS [eg.,1], LHD [eg., 2], TJ-II [eg., 3] and W7-AS [eg., 4]. The eITB isA defined as highly peaked electron temperature (Te) profile with strongly positive radial electric field (Er) in the central region. These observations are reviewed in this paper to understand the device-independent common findings and also to draw the main differences. This is the first report from the International Stellarator Profile Database Activity. The formation of the strong central positive Er has been understood mainly as a result of the ambipolarity of neoclassical electron and ion fluxes, although some additional convective electron flux such as driven by ECRH is required in some situations. This 'neoclassical' physics peculiar to low collisional regime of helical plasmas provides the commonly observed existence of the ECRH power threshold (which is also depending on the density). This is contrastive characteristics to the ITB observed in tokamaks. The dependence of the ECRH power threshold on the magnetic configuration and on the heating scenario among these devices are currently being examined by taking the effective ripple and the trapped particle fraction as parameters to achieve the comprehensive understanding. The roles of low order rational surfaces on the onset of eITB formation and also on its radial size (location of the footpoint of the eITB) have been indicated in inward shifted configurations in LHD (depending on the relative locations of heating position and 2/1 island) and TJ-II (eITB becomes possible at higher density when 3/2 rational is introduced in the plasma core region). It is speculated that, for the latter case, the resonance causes an extra electron flux to trigger the positive Er. The interplay between low order rational surfaces and the formation of eITB still waits for the systematic experiment and theoretical analysis. The external controllability

  18. Improvement of urban passenger transport ticketing systems by deploying intelligent transport systems

    Directory of Open Access Journals (Sweden)

    G. Jakubauskas

    2006-12-01

    Full Text Available The main advantages and disadvantages of conventional and intelligent ticketing systems and possible positive outcomes when introducing intelligent transport solutions – namely smart cards or e‑ticketing instead of conventional ones (paper tickets and magnetic cards are analysed in the paper. Two ideas of creating an intelligent ticketing system in an urban public transport are scrutinized. The first is electronic ticket and related equipment, the second – e-ticket and functional areas of it. In the article analysis has also been made on practical outcomes related with introduction of smart cards and e-ticketing. Practical tests and trials as well as a subsequent implementation of electronic tickets have proved unchallenged advantages of contactless smart cards against the contact ones. Nevertheless, a new age of modern technologies calls even for more effective solutions – namely virtual-ticketing systems that might be achieved through introduction of mobile technologies. Therefore, the main focus in the paper is made on the analysis of e-ticket.

  19. Decarbonizing Sweden’s energy and transportation system by 2050

    Directory of Open Access Journals (Sweden)

    Rasmus Bramstoft

    2017-01-01

    Full Text Available Decarbonizing Sweden’s transportation sector is necessary to realize its long-term vision of eliminating net greenhouse gas (GHG emissions from the energy system by 2050. Within this context, this study develops two scenarios for the transportation sector: one with high electrification (EVS and the other with high biofuel and biomethane utilization (BIOS. The energy system model STREAM is utilized to compute the socioeconomic system cost and simulate an integrated transportation, electricity, gas, fuel refinery, and heat system. The results show that electrifying a high share of Sweden’s road transportation yields the least systems cost. However, in the least-cost scenario (EVS, bioenergy resources account for 57% of the final energy use in the transportation sector. Further, a sensitivity analysis shows that the costs of different types of cars are the most sensitive parameters in the comparative analysis of the scenarios.

  20. Decarbonizing Sweden’s energy and transportation system by 2050

    DEFF Research Database (Denmark)

    Bramstoft, Rasmus; Skytte, Klaus

    2017-01-01

    Decarbonizing Sweden’s transportation sector is necessary to realize its long-term vision of eliminating net greenhouse gas (GHG) emissions from the energy system by 2050. Within this context, this study develops two scenarios for the transportation sector: one with high electrification (EVS......) and the other with high biofuel and biomethane utilization (BIOS). The energy system model STREAM is utilized to compute the socioeconomic system cost and simulate an integrated transportation, electricity, gas, fuel refinery, and heat system. The results show that electrifying a high share of Sweden’s road...... transportation yields the least systems cost. However, in the least-cost scenario (EVS), bioenergy resources account for 57% of the final energy use in the transportation sector. Further, a sensitivity analysis shows that the costs of different types of cars are the most sensitive parameters in the comparative...

  1. Public transport traffic management systems simulation in Craiova city

    Energy Technology Data Exchange (ETDEWEB)

    Racila, L.

    2016-07-01

    Urban transport is a comprehensive and dynamic mechanism. Therefore, all the problems for improving and reorganization of the system can be examined only in the light of a systemic approach. Currently, public passenger transport is one of the most important branches of the urban development in cities and metropolis. Public passenger transport activity and all the steps taken to improve that activity are considered to be of great social importance. In the current stage of city development, one of the main tasks is to create a public passenger transportation system that is safe, affordable, economical, reliable and environmentally friendly. The important role of passenger transport in the city's economy and achieving important social services to the population, dictates the need to introduce measures in the system that are harmonious, balanced and effective. This can only be done, in the context of current development, only after the system as a whole is tested extensively through special traffic and management software. (Author)

  2. Critical review of expert system validation in transportation

    Science.gov (United States)

    1997-01-01

    Expert system validationthat is, testing systems to ascertain whether they achieve acceptable performance levelshas with few exceptions been ad hoc, informal, and of dubious value. Very few efforts have been made in this regard in the transport...

  3. Environmental management system for transportation maintenance operations : [technical brief].

    Science.gov (United States)

    2014-04-01

    This report provides the framework for the environmental management system to analyze : greenhouse gas emissions from transportation maintenance operations. The system enables user : to compare different scenarios and make informed decisions to minim...

  4. FY17 Transportation and Hydrogen Systems Center Journal Publication Highlights

    Energy Technology Data Exchange (ETDEWEB)

    2017-12-08

    NREL's Transportation and Hydrogen Systems Center published 39 journal articles in fiscal year 2017 highlighting recent research in advanced vehicle technology, alternative fuels, and hydrogen systems.

  5. Decentralized control of multi-agent aerial transportation system

    KAUST Repository

    Toumi, Noureddine

    2017-01-01

    and Landing aircraft (VTOL) transportation system. We develop a decentralized method. The advantage of such a solution is that it can provide better maneuverability and lifting capabilities compared to existing systems. First, we consider a cooperative group

  6. Road Transport Management System (RTMS): a self regulation initiative in heavy vehicle transport in South Africa

    CSIR Research Space (South Africa)

    Nordengen, Paul A

    2007-07-01

    Full Text Available This paper describes the most recent developments of an initiative to introduce meaningful self-regulation in the heavy vehicle transport industry through a Road Transport Management System (RTMS) with the aim of contributing to the road authorities...

  7. Efficiency increase of complex production and transport systems management

    Directory of Open Access Journals (Sweden)

    Kornilov S.

    2017-01-01

    Full Text Available This article deals with the problem of the reduced efficiency of management in complex production - transport systems due to the lack of co-ordination in the operation of industrial enterprises and transport carrying out their maintenance. The existing transport service schedules for auxiliary departments do not take into account possible changes in operating conditions, the probability of malfunctions and the amount of reserves, which leads to an increase in general production costs. To solve this problem, we propose to use the interval regulation of production and transport processes in all departments of the complex production and transport systems. Also, such regulation involves the determination of traffic service priority. This will allow passing on from the regulated control of production and transport processes to the situational one, adapted to specific conditions, and reducing losses from untimely transport servicing, which will lead to a stores reduction and efficiency increase of the enterprise circulating facilities use. Testing the effectiveness of interval regulation was performed on the system and dynamics simulation model of liquid iron transportation in the oxygen converter shop of the metallurgical enterprise. It was established that the use of interval regulation processes in iron production and its transportation will allow decreasing non-productive downtime by 21% and the amount of the liquid iron in anticipation of recasting in the oxygen converter shop – by 33%. Economical effect of reducing the liquid iron downtime during transportation to the oxygen converter shop will be about 30 million rubles per year.

  8. Radioactive waste transportation systems analysis and program plan

    International Nuclear Information System (INIS)

    Shappert, L.B.; Joy, D.S.; Heiskell, M.M.

    1978-03-01

    The objective of the Transportation/Logistics Study is to ensure the availability of a viable system for transporting the wastes to a federal repository in 1985. In order to accomplish this objective, a systems analysis of waste transportation has been directed by ORNL to determine the problems that must be solved and to develop a program plan that identifies which problems must first be pursued. To facilitate this overall approach and to provide for short- and long-range waste management, logistics models have been developed to determine the transportation fleet requirements and costs. Results of the study are described in this report

  9. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

    Science.gov (United States)

    Aspelund, Aleksanteri; Antila, Salli; Proulx, Steven T; Karlsen, Tine Veronica; Karaman, Sinem; Detmar, Michael; Wiig, Helge; Alitalo, Kari

    2015-06-29

    The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system. Dural lymphatic vessels transport fluid into deep cervical LNs (dcLNs) via foramina at the base of the skull. In a transgenic mouse model expressing a VEGF-C/D trap and displaying complete aplasia of the dural lymphatic vessels, macromolecule clearance from the brain was attenuated and transport from the subarachnoid space into dcLNs was abrogated. Surprisingly, brain ISF pressure and water content were unaffected. Overall, these findings indicate that the mechanism of CSF flow into the dcLNs is directly via an adjacent dural lymphatic network, which may be important for the clearance of macromolecules from the brain. Importantly, these results call for a reexamination of the role of the lymphatic system in CNS physiology and disease. © 2015 Aspelund et al.

  10. Third-Order Transport with MAD Input: A Computer Program for Designing Charged Particle Beam Transport Systems

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Karl

    1998-10-28

    TRANSPORT has been in existence in various evolutionary versions since 1963. The present version of TRANSPORT is a first-, second-, and third-order matrix multiplication computer program intended for the design of static-magnetic beam transport systems.

  11. Environmental assessment of 9 European public bus transportation systems

    DEFF Research Database (Denmark)

    Nanaki, Eva; Koroneos, Christophis; Roset, Jaume

    2017-01-01

    that affect the production of carbon dioxide (CO2) as well as of air pollutants, in 9 major European cities, aiming to provide a comprehensive overview of the actual knowledge on the atmospheric pollution from public transportation systems. CO2 emissions as well as air pollutants, such as CO, HC, PM, NOx......The transportation sector is one of the largest sources of EU’s greenhouse gas emissions. In 2011, transportation represented approximately 25 percent of total EU’s greenhouse gas emissions. Urban mobility accounts for 40% of all CO2 emissions of road transport and up to 70% of other pollutants...... from transport. As, transportation and mobility play a crucial part both in urban economics and the quality of life, it is of great significance to ensure a low carbon transportation sector, so as to deal with the threat that climate change poses to urban areas. This study examines the factors...

  12. A comparison of the boomerang wire vascular access management system versus manual compression alone during percutaneous diagnostic and interventional cardiovascular procedures.

    Science.gov (United States)

    Echeverria, Angela; Krajcer, Zvonimir

    2016-01-01

    Vascular closure devices allow for early sheath removal, allowing for earlier patient mobilization The Boomerang vascular access management system does not alter arterial integrity for future interventions Access site complications provide significant morbidity in diagnostic and therapeutic interventions. © 2016 Wiley Periodicals, Inc.

  13. A system for transportation of hydrocarbons at sea; System for transport av hydrokarboner til havs

    Energy Technology Data Exchange (ETDEWEB)

    Breivik, K.; Smedal, A.

    1997-04-01

    To exploit the offshore oil and gas fields economically it is important to use suitable methods and equipment for transporting the oil and gas to the landing sites. The present invention concerns a system for transportation of hydrocarbons to the landing sites. It consists of one or more loading buoys and a number of preferably conventional tankers and at least one offshore loading ship arranged to receive hydrocarbons from the loading buoy to which it is connected by means of a coupling device in the ship`s bow. The tankers have in their sterns arrangements to convey the fluid through flexible tubes from complementary arrangements in the bow of the loading ship. The loading ship and the tanker have a position reference system for mutual dynamical positioning. The entire operation of connecting the tubes and transferring the fluid flow takes place with both ships moving, at least at steerage way. The invention aims to provide efficient use of the expensive special ships that are needed to communicate with the loading buoys. Another aim is to reduce the need for expensive specialized equipment onboard both the loading ships and the tankers. 5 figs.

  14. Shenzhen Comprehensive Transport System Planning:An Exploration of Sustainable Urban Transport Development on Condition of Limited Resources

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    With "integration" as the direction,Shenzhen Comprehensive Transport Planning integrates the plan,construction and management of all kinds of transport mode in the transport system,and integrates the transport with the social,economic and environment development.The planning specifies the strategic targets,key indicators,development strategies as well as major policies of the comprehensive transport system,which explores an alternative way for the sustainable urban transport development under the condition of limited resources in Shenzhen.

  15. United States Department of Energy Automated Transportation Management System

    International Nuclear Information System (INIS)

    Portsmouth, J.H.

    1992-01-01

    At the US Department of Energy (DOE) 80 transportation facilities, each contractor's transportation management operation has different internal and site specific procedures, and reports to a DOE regional Field Office Traffic Manager (FOTM). The DOE Transportation Management Program (TMP) has the responsibility to manage a transportation program for safe, efficient, and economical transportation of DOE-owned materials. The TMP develops and administers transportation/traffic operations management policies and programs for materials; including radioactive materials, other hazardous materials, hazardous substances, and hazardous wastes, pursuant to applicable federal regulations, such as the Code of Federal Register, Sections 40 and 49. Transportation management has become an increasingly critical primarily because of transportation issues regarding the shipment of radioactive materials and hazardous wastes that are frequently the focus of public concerns. A large shipments and requiring millions of business transactions necessitates the establishment of automated systems, programs, procedures, and controls to ensure that the transportation management process in being handled in a safe, efficient, and economical manner. As the mission of many DOE facilities changes from production of special nuclear materials for defense purposes to environmental restoration and waste management, the role of transportation management will become even more important to the safe and efficient movement of waste materials to prescribed locations. In support of this role, the Automated Transportation Management System (ATMS) was conceived to assist the DOE and its contractors in the performance of their day-to-day transportation management activities. The ATMS utilizes the latest in technology and will supply state-of-the-art automated transportation management for current and future DOE transportation requirements

  16. Study on tracking system for radioactive material transport

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, F.; Igarashi, M.; Nomura, T. [Nuclear Emergency Assistance and Training Center, Japan Nuclear Cycle Development Inst., Ibaraki (Japan); Nakagome, Y. [Research Reactor Inst., Kyoto Univ., Osaka (Japan)

    2004-07-01

    When a transportation accident occurs, all entities including the shipper, the transportation organization, local governments, and emergency response organizations must have organized and planned for civil safety, property, and environmental protection. When a transportation accident occurs, many related organizations will be involved, and their cooperation determines the success or failure of the response. The point where the accident happens cannot be pinpointed in advance. Nuclear fuel transportation also requires a quick response from a viewpoint of security. A tracking system for radioactive material transport is being developed for use in Japan. The objective of this system is, in the rare event of an accident, for communication capabilities to share specific information among relevant organizations, the transporter, and so on.

  17. Innovating for a competitive and resource-efficient transport system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-05-15

    Transport is vital to the economic prosperity and social integration of Europe. EU-transport policy is directed to developing a smart, efficient transport system with reduced dependency on fossil fuels and less environmental impacts that will enhance mobility in Europe and will underpin Europe's competitiveness in global markets. This includes the transport sector itself, which is an important part of the EU economy. In contributing to achieving these ambitious goals, extensive investments are made in research and development for sustainable and innovative solutions. This Policy Brochure, which is produced by the Transport Research and Innovation Portal (TRIP), highlights the contribution of research, development, and innovation in securing a competitive and resource-efficient transport system in Europe.

  18. Study on tracking system for radioactive material transport

    International Nuclear Information System (INIS)

    Watanabe, F.; Igarashi, M.; Nomura, T.; Nakagome, Y.

    2004-01-01

    When a transportation accident occurs, all entities including the shipper, the transportation organization, local governments, and emergency response organizations must have organized and planned for civil safety, property, and environmental protection. When a transportation accident occurs, many related organizations will be involved, and their cooperation determines the success or failure of the response. The point where the accident happens cannot be pinpointed in advance. Nuclear fuel transportation also requires a quick response from a viewpoint of security. A tracking system for radioactive material transport is being developed for use in Japan. The objective of this system is, in the rare event of an accident, for communication capabilities to share specific information among relevant organizations, the transporter, and so on

  19. Salt Repository Project transportation system interface requirements: Transportation system/repository receiving facility interface requirements

    International Nuclear Information System (INIS)

    Smith, L.A.; Insalaco, J.W.; Trainer, T.A.

    1988-01-01

    This report is a preliminary review of the interface between the transportation system and the repository receiving facility for a nuclear waste mined geologic disposal system in salt. Criteria for generic cask and facility designs are developed. These criteria are derived by examining the interfaces that occur as a result of the operations needed to receive nuclear waste at a repository. These criteria provide the basis for design of a safe, operable, practical nuclear waste receiving facility. The processing functions required to move the shipping unit from the gate into the unloading area and back to the gate for dispatch are described. Criteria for a generic receiving facility are discussed but no specific facility design is presented or evaluated. The criteria are stated in general terms to allow application to a wide variety of cask and facility designs. 9 refs., 6 figs., 4 tabs

  20. Control system of fuel transporting device

    International Nuclear Information System (INIS)

    Yokota, Minoru.

    1981-01-01

    Purpose: To effectively avoid an obstacle in a fuel transporting device by reading the outputs of absolute position detectors mounted on movable trucks, controlling the movements of the trucks, and thereby smoothly and accurately positioning the fuel transporting device at predetermined position and providing a contact detector thereat. Method: The outputs from absolute position detectors which are mounted on a longitudinally movable truck and a laterally movable truck are input to an input/output control circuit. The input/output control circuit serves to compare, the position a fuel transporting device is to be moved to, with the present position on the basis of said input detection signal and a command signal from an operator console, to calculate the amount of movement to be driven, to produce an operation signal therefor to a control panel, and to drive and control the drive motors which are respectively mounted on the trucks for the fuel transfer device. On the other hand, in case that the transfer device comes into contact with an obstacle, the contact detector will immediately operate to produce a stop command through the control panel to the transporting device, and avoid a collision with the obstacle. (Yoshino, Y.)

  1. Stochasticity and transport in Hamiltonian systems

    International Nuclear Information System (INIS)

    MacKay, R.S.; Meiss, J.D.; Percival, I.C.

    1983-08-01

    The theory of transport in nonlinear dynamics is developed in terms of leaky barriers which remain when invariant tori are destroyed. We describe the organization of stochastic motion by these barriers and give an explanation of long-time correlations in the stochastic regime

  2. Inelastic transport theory for nanoscale systems

    DEFF Research Database (Denmark)

    Frederiksen, Thomas

    2007-01-01

    This thesis describes theoretical and numerical investigations of inelastic scat- tering and energy dissipation in electron transport through nanoscale sys- tems. A computational scheme, based on a combination of density functional theory (DFT) and nonequilibrium Green’s functions (NEGF), has been...

  3. Control of machine functions or transport systems

    International Nuclear Information System (INIS)

    Woodley, M.D.; Lee, M.J.; Jaeger, J.; King, A.S.

    1983-01-01

    A computer code, COMFORT, has been developed at SLAC for on-line calculation of the strengths of magnetic elements in an electron storage ring or transport beam line, subject to first order fitting constraints on the ring or beam line parameters. This code can also be used off-line as an interactive lattice or beam line design tool

  4. Solute carrier transporters: potential targets for digestive system neoplasms.

    Science.gov (United States)

    Xie, Jing; Zhu, Xiao Yan; Liu, Lu Ming; Meng, Zhi Qiang

    2018-01-01

    Digestive system neoplasms are the leading causes of cancer-related death all over the world. Solute carrier (SLC) superfamily is composed of a series of transporters that are ubiquitously expressed in organs and tissues of digestive systems and mediate specific uptake of small molecule substrates in facilitative manner. Given the important role of SLC proteins in maintaining normal functions of digestive system, dysregulation of these protein in digestive system neoplasms may deliver biological and clinical significance that deserves systemic studies. In this review, we critically summarized the recent advances in understanding the role of SLC proteins in digestive system neoplasms. We highlighted that several SLC subfamilies, including metal ion transporters, transporters of glucose and other sugars, transporters of urea, neurotransmitters and biogenic amines, ammonium and choline, inorganic cation/anion transporters, transporters of nucleotide, amino acid and oligopeptide organic anion transporters, transporters of vitamins and cofactors and mitochondrial carrier, may play important roles in mediating the initiation, progression, metastasis, and chemoresistance of digestive system neoplasms. Proteins in these SLC subfamilies may also have diagnostic and prognostic values to particular cancer types. Differential expression of SLC proteins in tumors of digestive system was analyzed by extracting data from human cancer database, which revealed that the roles of SLC proteins may either be dependent on the substrates they transport or be tissue specific. In addition, small molecule modulators that pharmacologically regulate the functions of SLC proteins were discussed for their possible application in the treatment of digestive system neoplasms. This review highlighted the potential of SLC family proteins as drug target for the treatment of digestive system neoplasms.

  5. Transport and Power System Scenarios for Northern Europe in 2030

    DEFF Research Database (Denmark)

    Juul, Nina; Meibom, Peter

    2009-01-01

    it is assumed that power can go both from grid-to-vehicle and vehicle-to-grid. Oil prices are assumed to be $120/barrel, and CO2 price 40 €/ton. This results in an optimal investment path with a large increase in sustainable energy; primarily wind energy, as well as an increase in the electric drive vehicles......Increasing focus on sustainability affects all parts of the energy system. Integrating the power and transport system in future energy system planning, influences the economically optimal investments and optimal operation of the power system as well as the transport system. This work presents...... analysis of the optimal configuration and operation of the integrated power and transport system in Northern Europe. Optimal configuration and operation is obtained using the optimisation model, Balmorel [1], with a transport model extension. For electric drive vehicles with plug-in capabilities...

  6. Reaction-Transport Systems Mesoscopic Foundations, Fronts, and Spatial Instabilities

    CERN Document Server

    Horsthemke, Werner; Mendez, Vicenc

    2010-01-01

    This book is an introduction to the dynamics of reaction-diffusion systems, with a focus on fronts and stationary spatial patterns. Emphasis is on systems that are non-standard in the sense that either the transport is not simply classical diffusion (Brownian motion) or the system is not homogeneous. A important feature is the derivation of the basic phenomenological equations from the mesoscopic system properties. Topics addressed include transport with inertia, described by persistent random walks and hyperbolic reaction-transport equations and transport by anomalous diffusion, in particular subdiffusion, where the mean square displacement grows sublinearly with time. In particular reaction-diffusion systems are studied where the medium is in turn either spatially inhomogeneous, compositionally heterogeneous or spatially discrete. Applications span a vast range of interdisciplinary fields and the systems considered can be as different as human or animal groups migrating under external influences, population...

  7. Human behavior research and the design of sustainable transport systems

    Science.gov (United States)

    Schauer, James J.

    2011-09-01

    Transport currently represents approximately 19% of the global energy demand and accounts for about 23% of the global carbon dioxide emissions (IEA 2009). As the demand for mobility is expected to continue to increase in the coming decades, the stabilization of atmospheric carbon dioxide levels will require the evolution of transport, along with power generation, building design and manufacturing. The continued development of these sectors will need to include changes in energy sources, energy delivery, materials, infrastructure and human behavior. Pathways to reducing carbon from the transport sector have unique challenges and opportunities that are inherent to the human choices and behavioral patterns that mold the transportation systems and the associated energy needs. Technology, government investment, and regulatory policies have a significant impact on the formulation of transportation infrastructure; however, the role of human behavior and public acceptance on the efficiency and effectiveness of transport systems should not be underestimated. Although developed, rapidly developing, and underdeveloped nations face different challenges in the establishment of transport infrastructure that can meet transport needs while achieving sustainable carbon dioxide emissions, the constraints that establish the domain of possibilities are closely related for all nations. These constraints include capital investment, fuel supplies, power systems, and human behavior. Throughout the world, there are considerable efforts directed at advancing and optimizing the financing of sustainable infrastructures, the production of low carbon fuels, and the production of advanced power systems, but the foundational work on methods to understand human preferences and behavior within the context of transport and the valuation of reductions in carbon dioxide emissions is greatly lagging behind. These methods and the associated understanding of human behavior and the willingness to pay for

  8. Electrical Power Systems for NASA's Space Transportation Program

    Science.gov (United States)

    Lollar, Louis F.; Maus, Louis C.

    1998-01-01

    Marshall Space Flight Center (MSFC) is the National Aeronautics and Space Administration's (NASA) lead center for space transportation systems development. These systems include earth to orbit launch vehicles, as well as vehicles for orbital transfer and deep space missions. The tasks for these systems include research, technology maturation, design, development, and integration of space transportation and propulsion systems. One of the key elements in any transportation system is the electrical power system (EPS). Every transportation system has to have some form of electrical power and the EPS for each of these systems tends to be as varied and unique as the missions they are supporting. The Preliminary Design Office (PD) at MSFC is tasked to perform feasibility analyses and preliminary design studies for new projects, particularly in the space transportation systems area. All major subsystems, including electrical power, are included in each of these studies. Three example systems being evaluated in PD at this time are the Liquid Fly Back Booster (LFBB) system, the Human Mission to Mars (HMM) study, and a tether based flight experiment called the Propulsive Small Expendable Deployer System (ProSEDS). These three systems are in various stages of definition in the study phase.

  9. Space transportation systems within ESA programmes: Current status and perspectives

    Science.gov (United States)

    Delahais, Maurice

    1993-03-01

    An overview of the space transportation aspects of the ESA (European Space Agency) programs as they result from history, present status, and decisions taken at the ministerial level conference in Granada, Spain is presented. The new factors taken into consideration for the long term plan proposed in Munich, Germany, the three strategic options for the reorientation of the ESA long term plan, and the essential elements of space transportation in the Granada long term plan in three areas of space activities, scientific, and commercial launches with expendable launch vehicles, manned flight and in-orbit infrastructure, and future transportation systems are outlined. The new ESA long term plan, in the field of space transportation systems, constitutes a reorientation of the initial program contemplated in previous councils at ministerial level. It aims at balancing the new economic situation with the new avenues of cooperation, and the outcome will be a new implementation of the space transportation systems policy.

  10. Natural hazard impacts on transport systems: analyzing the data base of transport accidents in Russia

    Science.gov (United States)

    Petrova, Elena

    2015-04-01

    We consider a transport accident as any accident that occurs during transportation of people and goods. It comprises of accidents involving air, road, rail, water, and pipeline transport. With over 1.2 million people killed each year, road accidents are one of the world's leading causes of death; another 20-50 million people are injured each year on the world's roads while walking, cycling, or driving. Transport accidents of other types including air, rail, and water transport accidents are not as numerous as road crashes, but the relative risk of each accident is much higher because of the higher number of people killed and injured per accident. Pipeline ruptures cause large damages to the environment. That is why safety and security are of primary concern for any transport system. The transport system of the Russian Federation (RF) is one of the most extensive in the world. It includes 1,283,000 km of public roads, more than 600,000 km of airlines, more than 200,000 km of gas, oil, and product pipelines, 115,000 km of inland waterways, and 87,000 km of railways. The transport system, especially the transport infrastructure of the country is exposed to impacts of various natural hazards and weather extremes such as heavy rains, snowfalls, snowdrifts, floods, earthquakes, volcanic eruptions, landslides, snow avalanches, debris flows, rock falls, fog or icing roads, and other natural factors that additionally trigger many accidents. In June 2014, the Ministry of Transport of the RF has compiled a new version of the Transport Strategy of the RF up to 2030. Among of the key pillars of the Strategy are to increase the safety of the transport system and to reduce negative environmental impacts. Using the data base of technological accidents that was created by the author, the study investigates temporal variations and regional differences of the transport accidents' risk within the Russian federal regions and a contribution of natural factors to occurrences of different

  11. One-Loop Operation of Primary Heat Transport System in MONJU During Heat Transport System Modifications

    International Nuclear Information System (INIS)

    Goto, T.; Tsushima, H.; Sakurai, N.; Jo, T.

    2006-01-01

    MONJU is a prototype fast breeder reactor (FBR). Modification work commenced in March 2005. Since June 2004, MONJU has changed to one-loop operation of the primary heat transport system (PHTS) with all of the secondary heat transport systems (SHTS) drained of sodium. The purposes of this change are to shorten the modification period and to reduce the cost incurred for circuit trace heating electrical consumption. Before changing condition, the following issues were investigated to show that this mode of operation was possible. The heat loss from the reactor vessel and the single primary loop must exceed the decay heat by an acceptable margin but the capacity of pre-heaters to keep the sodium within the primary vessel at about 200 deg. C must be maintained. With regard to the heat loss and the decay heat, the estimated heat loss in the primary system was in the range of 90-170 kW in one-loop operation, and the calculated decay heat was 21.2 kW. Although the heat input of the primary pump was considered, it was clear that circuit heat loss greatly exceeded the decay heat. As for pre-heaters, effective capacity was less than the heat loss. Therefore, the temperature of the reactor vessel room was raised to reduce the heat loss. One-loop operation of the PHTS was able to be executed by means of these measures. The cost of electrical consumption in the power plant has been reduced by one-loop operation of the PHTS and the modification period was shortened. (authors)

  12. Development of hotcell transportation system technology for high radioactive material

    International Nuclear Information System (INIS)

    Seo, K. S.; Seo, C. S.; Lee, J. C.

    2012-04-01

    In the first stage of the research, the transportation and storage characteristics analysis of the pyroprocess materials, the development of horizontal type hot cell transportation system, and the design of interim storage system for the pyroprocess material are conducted. The optimized capacity, transportation frequency and operation period of pyroprocess facility are found using the logistics analysis program developed in this project. A new hot cell transportation system was designed. Through the safety analysis and test for the hot cell transportation system, the design license has been approved. A new type hot cell docking system with superior performance has been developed with a patented rotating lid system. We have reached to a unique concept of interim storage of pyroprocess materials and selected a system through a comparative evaluation of existing ones. In the second stage of the research, transportation/storage/sealing devices for PRIDE recovered material/wastes were developed. And test model for the devices in engineering scale facility were also developed. The design requirements for a vertical docking system were evaluated and the performance assessment using a scaled mock-up was conducted. Integrated storage management technology was evaluated for an efficient management of process materials. A heat transfer simulation and characteristics analysis for the storage system were conducted. The derivation of design requirements, design and fabrication of a canister test model, and preliminary safety assessment were conducted

  13. Spectral imaging based in vivo model system for characterization of tumor microvessel response to vascular targeting agents

    Science.gov (United States)

    Wankhede, Mamta

    Functional vasculature is vital for tumor growth, proliferation, and metastasis. Many tumor-specific vascular targeting agents (VTAs) aim to destroy this essential tumor vasculature to induce indirect tumor cell death via oxygen and nutrition deprivation. The tumor angiogenesis-inhibiting anti-angiogenics (AIs) and the established tumor vessel targeting vascular disrupting agents (VDAs) are the two major players in the vascular targeting field. Combination of VTAs with conventional therapies or with each other, have been shown to have additive or supra-additive effects on tumor control and treatment. Pathophysiological changes post-VTA treatment in terms of structural and vessel function changes are important parameters to characterize the treatment efficacy. Despite the abundance of information regarding these parameters acquired using various techniques, there remains a need for a quantitative, real-time, and direct observation of these phenomenon in live animals. Through this research we aspired to develop a spectral imaging based mouse tumor system for real-time in vivo microvessel structure and functional measurements for VTA characterization. A model tumor system for window chamber studies was identified, and then combinatorial effects of VDA and AI were characterized in model tumor system. (Full text of this dissertation may be available via the University of Florida Libraries web site. Please check http://www.uflib.ufl.edu/etd.html)

  14. Sintering boat transport system for the SAF line

    International Nuclear Information System (INIS)

    Egli, W.; Bogart, R.L.

    1983-10-01

    The Secure Automated Fabrication (SAF) line will be a remotely operated process for the manufacture of breeder reactor fuel pins. The sintering boat transport system will service the pellet operations. Since the Boat Transport System will be the major link between several subsystem operations, reliability and ease of maintenance are prime requirements for the design. A prototypic version of the Boat Transport System was designed, built and tested to verify the operability of the selected approach. Extensive testing provided valuable input to the final design and substantiated the soundness of the concept

  15. Transportation operations functions of the federal waste management system

    International Nuclear Information System (INIS)

    Shappert, L.B.; Klimas, M.J.

    1989-01-01

    This paper documents the functions that are necessary to operate the OCRWM transportation system. OCRWM's mission is to accept and transport spent fuel and high-level waste from waste generators to FWMS facilities. The emphasis is on transportation operations and assumes that all necessary facilities are in place and equipment designs and specifications are available to permit the system to operate properly. The information reported in this paper was developed for TOPO and is compatible with the draft revision of the Waste Management System Requirements and Description (SRD). 5 refs

  16. Modeling and Evaluation of LTE in Intelligent Transportation Systems

    NARCIS (Netherlands)

    Trichias, K.; van den Berg, Hans Leo; de Jongh, J.; Litjens, R.; Dimitrova, D.C.; Brogle, M.; Braun, T.; Heijenk, Gerhard J.; Meratnia, Nirvana

    The term Intelligent Transportation Systems (ITS) refers to adding information and communications technology to transport infrastructure and ve- hicles. The IEEE 802.11p standard is considered the main candidate for com- munication within the context of ITS and it performs well for active safety use

  17. Automated transportation management system (ATMS) software project management plan (SPMP)

    Energy Technology Data Exchange (ETDEWEB)

    Weidert, R.S., Westinghouse Hanford

    1996-05-20

    The Automated Transportation Management System (ATMS) Software Project Management plan (SPMP) is the lead planning document governing the life cycle of the ATMS and its integration into the Transportation Information Network (TIN). This SPMP defines the project tasks, deliverables, and high level schedules involved in developing the client/server ATMS software.

  18. Applying intelligent transport systems to manage noise impacts

    NARCIS (Netherlands)

    Wilmink, I.R.; Vonk, T.

    2015-01-01

    This contribution discusses how traffic management, and many other measures that can be categorised as Intelligent Transport Systems (ITS, i.e. all traffic and transport measures that use ICT) can help reduce noise levels by influencing mobility choices and driving behaviour. Several examples of

  19. Multimodal schedule design for synchromodal freight transport systems

    NARCIS (Netherlands)

    B. Behdani (Behzad); Y. Fan (Yun); B.W. Wiegmans (Bart); R.A. Zuidwijk (Rob)

    2016-01-01

    textabstractIntermodal freight transport has been discussed for decades as an alternative to unimodal road transport. However, it still does not represent a significant portion of the total freight market. A new and promising possibility to improve the performance of freight systems is the

  20. Multimodal schedule design for synchromodal freight transport systems

    NARCIS (Netherlands)

    Behdani, Behzad; Fan, Yun; Wiegmans, Bart; Zuidwijk, Rob

    2016-01-01

    Intermodal freight transport has been discussed for decades as an alternative to unimodal road transport. However, it still does not represent a significant portion of the total freight market. A new and promising possibility to improve the performance of freight systems is the synchromodal

  1. The emerging role of transport systems in liver function tests

    NARCIS (Netherlands)

    Stieger, Bruno; Heger, Michal; de Graaf, Wilmar; Paumgartner, Gustav; van Gulik, Thomas

    2012-01-01

    Liver function tests are of critical importance for the management of patients with severe or terminal liver disease. They are also used as prognostic tools for planning liver resections. In recent years many transport systems have been identified that also transport substances employed in liver

  2. Chromatic correction for the final transport system

    International Nuclear Information System (INIS)

    Brown, K.L.; Peterson, J.M.

    1980-01-01

    The final transport and focusing of the heavy-ion beam onto the fusion pellet in vacuum is complicated by several non-linear effects - namely, chromatic (momentum dependent) effects, geometric aberrations, and space-charge forces. This paper gives an example of how the chromatic effects can be nullified, at least to second order. Whether third- or higher-order terms are important is not yet clear. Space-charge effects are important but are not considered here

  3. Transport and Dynamics in Toroidal Fusion Systems

    International Nuclear Information System (INIS)

    Sovinec, Carl

    2016-01-01

    The study entitled, 'Transport and Dynamics in Toroidal Fusion Systems,' (TDTFS) applied analytical theory and numerical computation to investigate topics of importance to confining plasma, the fourth state of matter, with magnetic fields. A central focus of the work is how non-thermal components of the ion particle distribution affect the 'sawtooth' collective oscillation in the core of the tokamak magnetic configuration. Previous experimental and analytical research had shown and described how the oscillation frequency decreases and amplitude increases, leading to 'monster' or 'giant' sawteeth, when the non-thermal component is increased by injecting particle beams or by exciting ions with imposed electromagnetic waves. The TDTFS study applied numerical computation to self-consistently simulate the interaction between macroscopic collective plasma dynamics and the non-thermal particles. The modeling used the NIMROD code [Sovinec, Glasser, Gianakon, et al., J. Comput. Phys. 195, 355 (2004)] with the energetic component represented by simulation particles [Kim, Parker, Sovinec, and the NIMROD Team, Comput. Phys. Commun. 164, 448 (2004)]. The computations found decreasing growth rates for the instability that drives the oscillations, but they were ultimately limited from achieving experimentally relevant parameters due to computational practicalities. Nonetheless, this effort provided valuable lessons for integrated simulation of macroscopic plasma dynamics. It also motivated an investigation of the applicability of fluid-based modeling to the ion temperature gradient instability, leading to the journal publication [Schnack, Cheng, Barnes, and Parker, Phys. Plasmas 20, 062106 (2013)]. Apart from the tokamak-specific topics, the TDTFS study also addressed topics in the basic physics of magnetized plasma and in the dynamics of the reversed-field pinch (RFP) configuration. The basic physics work contributed to a study of two

  4. Transport and Dynamics in Toroidal Fusion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Sovinec, Carl [Univ. of Wisconsin, Madison, WI (United States)

    2016-09-07

    The study entitled, "Transport and Dynamics in Toroidal Fusion Systems," (TDTFS) applied analytical theory and numerical computation to investigate topics of importance to confining plasma, the fourth state of matter, with magnetic fields. A central focus of the work is how non-thermal components of the ion particle distribution affect the "sawtooth" collective oscillation in the core of the tokamak magnetic configuration. Previous experimental and analytical research had shown and described how the oscillation frequency decreases and amplitude increases, leading to "monster" or "giant" sawteeth, when the non-thermal component is increased by injecting particle beams or by exciting ions with imposed electromagnetic waves. The TDTFS study applied numerical computation to self-consistently simulate the interaction between macroscopic collective plasma dynamics and the non-thermal particles. The modeling used the NIMROD code [Sovinec, Glasser, Gianakon, et al., J. Comput. Phys. 195, 355 (2004)] with the energetic component represented by simulation particles [Kim, Parker, Sovinec, and the NIMROD Team, Comput. Phys. Commun. 164, 448 (2004)]. The computations found decreasing growth rates for the instability that drives the oscillations, but they were ultimately limited from achieving experimentally relevant parameters due to computational practicalities. Nonetheless, this effort provided valuable lessons for integrated simulation of macroscopic plasma dynamics. It also motivated an investigation of the applicability of fluid-based modeling to the ion temperature gradient instability, leading to the journal publication [Schnack, Cheng, Barnes, and Parker, Phys. Plasmas 20, 062106 (2013)]. Apart from the tokamak-specific topics, the TDTFS study also addressed topics in the basic physics of magnetized plasma and in the dynamics of the reversed-field pinch (RFP) configuration. The basic physics work contributed to a study of two-fluid effects on interchange dynamics, where

  5. Design of an Autonomous Transport System for Coastal Areas

    Directory of Open Access Journals (Sweden)

    Andrzej Lebkowski

    2018-03-01

    Full Text Available The article presents a project of an autonomous transport system that can be deployed in coastal waters, bays or between islands. Presented solutions and development trends in the transport of autonomous and unmanned units (ghost ships are presented. The structure of the control system of autonomous units is discussed together with the presentation of applied solutions in the field of artificial intelligence. The paper presents the concept of a transport system consisting of autonomous electric powered vessels designed to carry passengers, bikes, mopeds, motorcycles or passenger cars. The transport task is to be implemented in an optimal way, that is, most economically and at the same time as safe as possible. For this reason, the structure of the electric propulsion system that can be found on such units is shown. The results of simulation studies of autonomous system operation using simulator of marine navigational environment are presented.

  6. Permissible state permit/fee systems for radioactive materials transportation

    International Nuclear Information System (INIS)

    Friel, L.

    1987-01-01

    Many state permit/fee systems for radioactive materials transportation have been ruled inconsistent with federal law invalidated by the courts. As the date for repository operation, and its associated transportation, draws near, more states can be expected to adopt permit/fee systems. Examination of the U.S. Department of Transportation's advisory rulings and federal court cases on previous permit/fee systems gives general guidance on the type of permit/fee systems most likely to withstand challenges. Such a system would: have a simplified permit application with minimal information requirements; address a federally-defined class of hazardous or radioactive materials; allow access to all shipments conducted in compliance with federal law; charge a fee reasonably related to the costs imposed on the state by the transportation; and minimize the potential for re-directing shipments to other jurisdictions

  7. Solutions to Improve Person Transport System in the Pitesti City by Analyzing Public Transport vs. Private Transport

    Science.gov (United States)

    Mihaela, Istrate; Alexandru, Boroiu; Viorel, Nicolae; Ionel, Vieru

    2017-10-01

    One of the major problems facing the Pitesti city is the road congestion that occurs in the central area of the city during the peak hours. With all the measures taken in recent years - the widening of road arteries, increasing the number of parking spaces, the creation of overground road passages - it is obvious that the problem can only be solved by a new philosophy regarding urban mobility: it is no longer possible to continue through solutions to increase the accessibility of the central area of the city, but it is necessary, on the contrary, to promote a policy of discouraging the penetration of vehicles in the city center, coupled with a policy of improving the connection between urban public transport and county public transport. This new approach is also proposed in the new Urban Mobility Plan of Pitesti city, under development. The most convincing argument for the necessity of this new orientation in the Pitesti city mobility plan is based on the analysis of the current situation of passenger transport on the territory of Pitesti city: the analysis of “public transport versus private transport” reveals a very low occupancy rate for cars and the fact that the road surface required for a passenger (the dynamic area) is much higher in the case of private transport than in the case of public transport. Measurements of passenger flows and vehicle flows on the 6 penetration ways in the city have been made and the calculations clearly demonstrate the benefits of an urban public transport system connected by “transshipment buses” to be made at the edge of the city, to the county public transport system. In terms of inter-county transport, it will continue to be connected to the urban public transport system by existing bus Station, within the city: South Bus Station and North Bus Station. The usefulness of the paper is that it identifies the solutions for sustainable mobility in Pitesti city and proposes concrete solutions for the development of the

  8. Transportation System Risk Assessment on DOE Defense Program shipments

    International Nuclear Information System (INIS)

    Brumburgh, G.P.; Kimura, C.Y.; Alesso, H.P.; Prassinos, P.G.

    1992-01-01

    Substantial effort has been expended concerning the level of safety provided to persons, property, and the environment from the hazards associated with transporting radioactive material. This work provided an impetus for the Department of Energy to investigate the use of probabilistic risk assessment techniques to supplement the deterministic approach to transportation safety. The DOE recently decided to incorporate the methodologies associated with PRAs in the process for authorizing the transportation of nuclear components, special assemblies, and radioactive materials affiliated with the DOE Defense Program. Accordingly, the LLNL, sponsored by the DOE/AL, is tasked with developing a safety guide series to provide guidance to preparers performing a transportation system risk assessment

  9. The WIPP transportation system -- ''Safer than any other''

    International Nuclear Information System (INIS)

    Ward, T.R.; Spooner, R.

    1991-01-01

    The Department of Energy (DOE) has developed an integrated transportation system to transport transuranic (TRU) waste from ten widely dispersed generator sites to the Waste Isolation Pilot Plant (WIPP). The system consists of a Type B container, a specially designed trailer, a lightweight tractor, the DOE TRANSCOM satellite-based vehicle tracking system, and uniquely qualified and highly trained drivers. The DOE has demonstrated that this system is ready to transport the TRU waste to the WIPP site efficiently and safely. Since the system was put in place in November 1988, it has been repeatedly upgraded and enhanced to incorporate additional safety measures. In June of 1989, the National Academy of Sciences (NAS) reviewed the transportation system and concluded that ''the system proposed for transportation of TRU waste to WIPP is safer than that employed for any other hazardous material in the United States today and will reduce risk to very low levels'' (emphasis added). The NAS conclusion was made before the DOE implemented the Enhanced Driver Training Course for carrier drivers. The challenge facing the DOE was to examine the transportation system objectively and determine what additional improvements could be made to further enhance safety

  10. Intraocular and systemic levels of vascular endothelial growth factor in advanced cases of retinopathy of prematurity

    Science.gov (United States)

    Velez-Montoya, Raul; Clapp, Carmen; Rivera, Jose Carlos; Garcia-Aguirre, Gerardo; Morales-Cantón, Virgilio; Fromow-Guerra, Jans; Guerrero-Naranjo, Jose Luis; Quiroz-Mercado, Hugo

    2010-01-01

    Purpose: To measure vitreous, aqueous, subretinal fluid and plasma levels of vascular endothelial growth factor in late stages of retinopathy of prematurity. Methods: Interventional study. We enrolled patients with clinical diagnoses of bilateral stage V retinopathy of prematurity, confirmed by b-scan ultrasound and programmed for vitrectomy. During surgery we took samples from blood, aqueous, vitreous, and subretinal fluids. The vascular endothelial growth factor concentration in each sample was measured by ELISA reaction. A control sample of aqueous, vitreous and blood was taken from patients with congenital cataract programmed for phacoemulsification. For statistical analysis, a Mann–Whitney and a Wilcoxon W test was done with a significant P value of 0.05. Results: We took samples of 16 consecutive patients who met the inclusion criteria. The vascular endothelial growth factor levels in the study group were: aqueous, 76.81 ± 61.89 pg/mL; vitreous, 118.53 ± 65.87 pg/mL; subretinal fluid, 1636.58 ± 356.47 pg/mL; and plasma, 74.64 ± 43.94 pg/mL. There was a statistical difference between the study and the control group (P < 0.001) in the aqueous and vitreous samples. Conclusion: Stage 5 retinopathy of prematurity has elevated intraocular levels of vascular endothelial growth factor, which remains high despite severe retinal lesion. There was no statistical difference in plasma levels of the molecule between the control and study group. PMID:20856587

  11. Estimated routine radiation doses to transportation workers in alternative spent-fuel transportation systems

    International Nuclear Information System (INIS)

    Schneider, K.J.; Smith, R.I.; Daling, P.M.; Ross, W.A.; McNair, G.W.

    1988-01-01

    The federal system for the management of spent fuel and high-level radioactive waste includes the acceptance by the US Department of Energy (DOE) of the spent fuel or waste loaded in casks at the reactor or other waste generators, its transportation to a repository, and its handling and final emplacement in the repository. The DOE plans to implement a transportation system that is safe, secure, efficient, and cost-effective and will meet applicable regulatory safety and security requirements. The DOE commissioned the Pacific Northwest Laboratory (PNL) to develop estimates of the routine radiation doses that would result from the operation of a system postulated using current designs and practices. From that evaluation, PNL identified activities/operations that result in the higher fraction of doses, proposed conceptual alternatives that would effectively reduce such exposures, and evaluated the cost-effectiveness of such alternatives. The study is one of a series used in making overall system design and operational decisions in the development of the DOE's spent-fuel/high-level waste transportation system. This paper contains the highlights from the PNL study of the estimated radiation doses to the transportation workers in a postulated reference transportation system and potential alternatives to that system

  12. Dynamic Measurement of Tumor Vascular Permeability and Perfusion using a Hybrid System for Simultaneous Magnetic Resonance and Fluorescence Imaging.

    Science.gov (United States)

    Ren, Wuwei; Elmer, Andreas; Buehlmann, David; Augath, Mark-Aurel; Vats, Divya; Ripoll, Jorge; Rudin, Markus

    2016-04-01

    Assessing tumor vascular features including permeability and perfusion is essential for diagnostic and therapeutic purposes. The aim of this study was to compare fluorescence and magnetic resonance imaging (MRI)-based vascular readouts in subcutaneously implanted tumors in mice by simultaneous dynamic measurement of tracer uptake using a hybrid fluorescence molecular tomography (FMT)/MRI system. Vascular permeability was measured using a mixture of extravascular imaging agents, GdDOTA and the dye Cy5.5, and perfusion using a mixture of intravascular agents, Endorem and a fluorescent probe (Angiosense). Dynamic fluorescence reflectance imaging (dFRI) was integrated into the hybrid system for high temporal resolution. Excellent correspondence between uptake curves of Cy5.5/GdDOTA and Endorem/Angiosense has been found with correlation coefficients R > 0.98. The two modalities revealed good agreement regarding permeability coefficients and centers-of-gravity of the imaging agent distribution. The FMT/dFRI protocol presented is able to accurately map physiological processes and poses an attractive alternative to MRI for characterizing tumor neoangiogenesis.

  13. Effect of heat stress on cardiac output and systemic vascular conductance during simulated hemorrhage to presyncope in young men

    DEFF Research Database (Denmark)

    Ganio, Matthew S; Overgaard, Morten; Seifert, Thomas

    2012-01-01

    During moderate actual or simulated hemorrhage, as cardiac output decreases, reductions in systemic vascular conductance (SVC) maintain mean arterial pressure (MAP). Heat stress, however, compromises the control of MAP during simulated hemorrhage, and it remains unknown whether this response is due...... to a persistently high SVC and/or a low cardiac output. This study tested the hypothesis that an inadequate decrease in SVC is the primary contributing mechanism by which heat stress compromises blood pressure control during simulated hemorrhage. Simulated hemorrhage was imposed via lower body negative pressure...... normothermic is no longer adequate during a heat-stressed-simulated hemorrhage. The absence of a decrease in SVC at a time of profound reductions in MAP suggests that inadequate control of vascular conductance is a primary mechanism compromising blood pressure control during these conditions....

  14. US Department of Energy Automated Transportation Management System

    International Nuclear Information System (INIS)

    Portsmouth, J.H.

    1994-01-01

    The U.S. Department of Energy (DOE) Transportation Management Division (TMD) is responsible for managing its various programs via a diverse combination of Government-Owned/Contractor-Operated facilities. TMD is seeking to update it automation capabilities in capturing and processing DOE transportation information. TMD's Transportation Information Network (TIN) is an attempt to bring together transportation management, shipment tracking, research activities and software products in various stages of development. The TMD's Automated Transportation Management System (ATMS) proposes to assist the DOE and its contractors in performing their daily transportation management activities and to assist the DOE Environmental Management Division in its waste management responsibilities throughout the DOE complex. The ATMS system will center about the storage, handling and documentation involved in the environmental clean-up of DOE sites. Waste shipments will be moved to approved Treatment, Storage and Disposal (TSD) facilities and/or nuclear material repositories. An additional investment in shipping samples to analytical laboratories also involves packaging and documentation according to all applicable U.S. Department of Transportation (DOT) or International Air Transport Association (IATA) regulations. The most immediate goal of effectively managing DOE transportation management functions during the 1990's is an increase in automation capabilities of the DOE and its contractors. Subject-matter experts from various DOE site locations will be brought together to develop and refine these capabilities through the maximum use of computer applications. A major part of this effort will be the identification of the most economical modes of transportation and enhanced management reporting capabilities for transportation analysis. The ATMS system will also provide for increased strategic and shipment analysis during the 1990's and beyond in support of the DOE environmental mission

  15. Los Alamos radiation transport code system on desktop computing platforms

    International Nuclear Information System (INIS)

    Briesmeister, J.F.; Brinkley, F.W.; Clark, B.A.; West, J.T.

    1990-01-01

    The Los Alamos Radiation Transport Code System (LARTCS) consists of state-of-the-art Monte Carlo and discrete ordinates transport codes and data libraries. These codes were originally developed many years ago and have undergone continual improvement. With a large initial effort and continued vigilance, the codes are easily portable from one type of hardware to another. The performance of scientific work-stations (SWS) has evolved to the point that such platforms can be used routinely to perform sophisticated radiation transport calculations. As the personal computer (PC) performance approaches that of the SWS, the hardware options for desk-top radiation transport calculations expands considerably. The current status of the radiation transport codes within the LARTCS is described: MCNP, SABRINA, LAHET, ONEDANT, TWODANT, TWOHEX, and ONELD. Specifically, the authors discuss hardware systems on which the codes run and present code performance comparisons for various machines

  16. Cesium transport data for HTGR systems

    International Nuclear Information System (INIS)

    Myers, B.F.; Bell, W.E.

    1979-09-01

    Cesium transport data on the release of cesium from HTGR fuel elements are reviewed and discussed. The data available through 1976 are treated. Equations, parameters, and associated variances describing the data are presented. The equations and parameters are in forms suitable for use in computer codes used to calculate the release of metallic fission products from HTGR fuel elements into the primary circuit. The data cover the following processes: (1) diffusion of cesium in fuel kernels and pyrocarbon, (2) sorption of cesium on fuel rod matrix material and on graphite, and (3) migration of cesium in graphite. The data are being confirmed and extended through work in progress

  17. Elements of transport and emplacement system

    International Nuclear Information System (INIS)

    1981-02-01

    This report, undertaken to review proposals for transport, handling and emplacement of high-level radioactive wastes in an underground repository, appropriate to the U.K. context, falls under the headings: basic design concepts; waste block size and configuration; self-shielded or partially shielded blocks; concept of emplacement in long boreholes; concept of emplacement in short boreholes; concept of emplacement in tunnels; methods of emplacement; stages of disposal; repository access by adit, incline or shaft; handling techniques within repository; conventional and radiological safety; costs; areas for further research and development. (U.K.)

  18. MINIX SYSTEM TRANSPORTATION TO CYGNUS COMPUTER

    OpenAIRE

    GUILHERMO ESTEBAN SOSA BELTRAN

    1988-01-01

    O sistema operacional MINIX é uma nova implementação do sistema UNIX, versão 7, feito para fins didáticos. Ele está formado por uma coleção de processos, estruturados em 4 niveis: administração de processos, processos básicos do sistema, processos servidores de memória e arquivos, e processos usuários. A presente dissertação descreve o transporte do sistema MINIX, do microcomputador IBM PC XT para o computador CYGNUS do laboratório de Sistema de Computação do D...

  19. Advanced Public Transportation Systems. Technical Assistance Brief 2

    Science.gov (United States)

    1993-01-01

    The Advanced Public Transportation Systems (APTS) Program requires evaluation : of pilot projects. This technical assistance brief discusses the guidelines set : for developing evaluation framework and methodology for local projects. 4p.

  20. Advanced public transportation system deployment in the United States

    Science.gov (United States)

    1999-01-01

    This report documents work performed under FTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communication techn...

  1. Advanced public transportation systems : the state of the art

    Science.gov (United States)

    1991-03-01

    This report documents one of the early initiatives of UMTA's Advanced Public Transportation Systems (APTS) Program, a program structured to undertake research and development of innovative applications of advanced navigation, information, and communi...

  2. Benefits assessment of advanced public transportation system technologies, update 2000

    Science.gov (United States)

    This report was performed under the Federal Transit Administration's (FTA) Advanced Public Transportation Systems (APTS) Program. This program focuses on the development and demonstration of innovative advanced navigation, information and communicati...

  3. The public transportation system security and emergency preparedness planning guide

    Science.gov (United States)

    2003-01-01

    Recent events have focused renewed attention on the vulnerability of the nation's critical infrastructure to major events, including terrorism. The Public Transportation System Security and Emergency Preparedness Planning Guide has been prepared to s...

  4. Intelligent transportation systems data compression using wavelet decomposition technique.

    Science.gov (United States)

    2009-12-01

    Intelligent Transportation Systems (ITS) generates massive amounts of traffic data, which posts : challenges for data storage, transmission and retrieval. Data compression and reconstruction technique plays an : important role in ITS data procession....

  5. Evaluation of Communication Alternatives for Intelligent Transportation Systems

    Science.gov (United States)

    2010-08-31

    The primary focus of this study involved developing a process for the evaluation of wireless technologies : for intelligent transportation systems, and for conducting experiments of potential wireless technologies : and topologies. Two wireless techn...

  6. Public transportation systems: Comparative analysis of quality of service

    Energy Technology Data Exchange (ETDEWEB)

    Negri, L.; Florio, L. (Rome Univ. La Sapienza (Italy). Facolta' di Ingegneria, Dipt. di Idraulica, Trasporti e Strade)

    The evaluation, choice and design of public transportation systems for urban areas requires, in addition to consolidated use parameters, other dimensions essential to supply-demand qualiflcative realignment, e.g.: 'door-to-door time' which allows system differentiation in terms of commercial velocity, frequency and length of route; technical productivity expressed as 'transport power' and 'specific transport power'; and 'system/service quality'. By the means of surveys, these factors can be incorporated into suitable mathematical models representing, in a complete and reliable way, all the functions which a given system actually delivers and those functions which it is expected to deliver by its users. This paper illustrates the application of these concepts in a comparative analysis of different public transportation options - light rail rapid transit, tram and bus networks.

  7. Advances in dynamic network modeling in complex transportation systems

    CERN Document Server

    Ukkusuri, Satish V

    2013-01-01

    This book focuses on the latest in dynamic network modeling, including route guidance and traffic control in transportation systems and other complex infrastructure networks. Covers dynamic traffic assignment, flow modeling, mobile sensor deployment and more.

  8. MODERN AND PERSPECTIVE ON-BOARD NTELLECTUAL TRANSPORT SYSTEMS

    Directory of Open Access Journals (Sweden)

    V. Topalidi

    2011-01-01

    Full Text Available For the purpose of systematization of modern and perspective intellectual transport sides systems (ITВS it is suggested their classification and planning of new ITВS for realization of safety control of vehicle technical condition.

  9. A Study of Transport Airplane Crash-Resistant Fuel Systems

    National Research Council Canada - National Science Library

    Robertson, S

    2002-01-01

    ...), of transport airplane crash-resistant fuel system (CRFS). The report covers the historical studies related to aircraft crash fires and fuel containment concepts undertaken by the FAA, NASA, and the U.S...

  10. An Artificial Neural Network Controller for Intelligent Transportation Systems Applications

    Science.gov (United States)

    1996-01-01

    An Autonomous Intelligent Cruise Control (AICC) has been designed using a feedforward artificial neural network, as an example for utilizing artificial neural networks for nonlinear control problems arising in intelligent transportation systems appli...

  11. Intelligent transportation systems business plan for Kentucky : final report.

    Science.gov (United States)

    2001-09-01

    This report presents a Business Plan for Intelligent Transportation Systems (ITS) in Kentucky. The purpose of the Business Plan is to define ITS projects that are planned for implementation from 2002 through 2007. The list of projects contained withi...

  12. Alternative Transportation System Demand Estimation for Federal Land Management Agencies.

    Science.gov (United States)

    2011-09-30

    Estimating travel demand for alternative transportation systems (ATS) is challenging in any context, but is even more daunting for Federal Land Management Agencies (FLMAs). Federal public land sites vary widely in their characteristics. Moreover, tra...

  13. Innovations in pricing of transportation systems : theory and practice.

    Science.gov (United States)

    2011-08-15

    This report summarizes results from the conference titled Innovations in Pricing of : Transportation Systems on May 12 14, 2010 at the Royal Plaza Hotel in Orlando, Florida. : The primary objective of the conference is to bring together pra...

  14. Developing a market-sensitive intelligent transportation systems educational program

    Science.gov (United States)

    1997-01-01

    Results of research undertaken to evaluate the educational needs of the emerging field of Intelligent Transportation Systems (ITSs) are presented, and whether course offerings in academic programs meet these needs is ascertained. A survey was conduct...

  15. MRS [monitored retrievable storage] to transportation system interfaces

    International Nuclear Information System (INIS)

    Row, T.H.; Croff, A.G.

    1987-01-01

    In March 1987, the US Department of Energy presented to Congress the proposal to construct and operate a facility for the monitored retrievable storage (MRS) of spent fuel at a site on the Clinch River in the Roane County portions of Oak Ridge. In discussing the MRS to Transportation System Interfaces, the authors provide a blending of the technical and institutional issues, for they do not believe the solutions to success of this enterprise lie wholly in one area. The authors cover: early chronology of the MRS; comparison of total-system life cycle cost estimates of the authorized system and improved-performance system (i.e., the system that includes a facility for MRS); transportation costs resulting from shipping, security and cask; assumptions for dedicated rail transport from MRS to repository; and significant results from the Total System Life Cycle Cost (TSLCC) analysis of the improved performance system. (AT)

  16. Significance of cardiac sympathetic nervous system abnormality for predicting vascular events in patients with idiopathic paroxysmal atrial fibrillation

    International Nuclear Information System (INIS)

    Akutsu, Yasushi; Kaneko, Kyouichi; Kodama, Yusuke; Li, Hui-Ling; Kawamura, Mitsuharu; Asano, Taku; Hamazaki, Yuji; Tanno, Kaoru; Kobayashi, Youichi; Suyama, Jumpei; Shinozuka, Akira; Gokan, Takehiko

    2010-01-01

    Neuronal system activity plays an important role for the prognosis of patients with atrial fibrillation (AF). Using 123 I metaiodobenzylguanidine ( 123 I-MIBG) scintigraphy, we investigated whether a cardiac sympathetic nervous system (SNS) abnormality would be associated with an increased risk of vascular events in patients with paroxysmal AF. 123 I-MIBG scintigraphy was performed in 69 consecutive patients (67 ± 13 years, 62% men) with paroxysmal AF who did not have structural heart disease. SNS integrity was assessed from the heart to mediastinum (H/M) ratio on delayed imaging. Serum concentration of C-reactive protein (CRP) was measured before 123 I-MIBG study. During a mean of 4.5 ± 3.6 years follow-up, 19 patients had myocardial infarction, stroke or heart failure (range: 0.2-11.5 years). SNS abnormality (H/M ratio <2.7) and high CRP (≥0.3 mg/dl) were associated with the vascular events (58.3% in 14 of 24 patients with SNS abnormality vs 11.1% in 5 of 45 patients without SNS abnormality, p < 0.0001, 52.4% in 11 of 21 patients with high CRP vs 16.7% in 8 of 48 patients without high CRP, p < 0.0001). After adjustment for potential confounding variables such as age, left atrial dimension and left ventricular function, SNS abnormality was an independent predictor of vascular events with a hazard ratio of 4.1 [95% confidence interval (CI): 1.3-12.6, p = 0.014]. Further, SNS abnormality had an incremental and additive prognostic power in combination with high CRP with an adjusted hazard ratio of 4.1 (95% CI: 1.5-10.9, p = 0.006). SNS abnormality is predictive of vascular events in patients with idiopathic paroxysmal AF. (orig.)

  17. Significance of cardiac sympathetic nervous system abnormality for predicting vascular events in patients with idiopathic paroxysmal atrial fibrillation

    Energy Technology Data Exchange (ETDEWEB)

    Akutsu, Yasushi; Kaneko, Kyouichi; Kodama, Yusuke; Li, Hui-Ling; Kawamura, Mitsuharu; Asano, Taku; Hamazaki, Yuji; Tanno, Kaoru; Kobayashi, Youichi [Showa University School of Medicine, Division of Cardiology, Department of Medicine, Tokyo (Japan); Suyama, Jumpei; Shinozuka, Akira; Gokan, Takehiko [Showa University School of Medicine, Department of Radiology, Tokyo (Japan)

    2010-04-15

    Neuronal system activity plays an important role for the prognosis of patients with atrial fibrillation (AF). Using {sup 123}I metaiodobenzylguanidine ({sup 123}I-MIBG) scintigraphy, we investigated whether a cardiac sympathetic nervous system (SNS) abnormality would be associated with an increased risk of vascular events in patients with paroxysmal AF. {sup 123}I-MIBG scintigraphy was performed in 69 consecutive patients (67 {+-} 13 years, 62% men) with paroxysmal AF who did not have structural heart disease. SNS integrity was assessed from the heart to mediastinum (H/M) ratio on delayed imaging. Serum concentration of C-reactive protein (CRP) was measured before {sup 123}I-MIBG study. During a mean of 4.5 {+-} 3.6 years follow-up, 19 patients had myocardial infarction, stroke or heart failure (range: 0.2-11.5 years). SNS abnormality (H/M ratio <2.7) and high CRP ({>=}0.3 mg/dl) were associated with the vascular events (58.3% in 14 of 24 patients with SNS abnormality vs 11.1% in 5 of 45 patients without SNS abnormality, p < 0.0001, 52.4% in 11 of 21 patients with high CRP vs 16.7% in 8 of 48 patients without high CRP, p < 0.0001). After adjustment for potential confounding variables such as age, left atrial dimension and left ventricular function, SNS abnormality was an independent predictor of vascular events with a hazard ratio of 4.1 [95% confidence interval (CI): 1.3-12.6, p = 0.014]. Further, SNS abnormality had an incremental and additive prognostic power in combination with high CRP with an adjusted hazard ratio of 4.1 (95% CI: 1.5-10.9, p = 0.006). SNS abnormality is predictive of vascular events in patients with idiopathic paroxysmal AF. (orig.)

  18. Riboflavin transport in the central nervous system. Characterization and effects of drugs.

    OpenAIRE

    Spector, R

    1980-01-01

    The relationship of riboflavin transport to the transport of other substances including drugs in rabbit choroid plexus, the anatomical locus of the blood-cerebrospinal fluid barrier, and brain cells were studied in vivo and in vitro. In vitro, the ability of rabbit choroid plexus to transport riboflavin from the medium (cerebrospinal fluid surface) through the choroid plexus epithelial cells into the extracellular and vascular spaces of the choroid plexus was documented using fluorescence mic...

  19. Towards a Hyperconnected Transportation Management System: Application to Blood Logistics

    OpenAIRE

    Schoen , Quentin; Lauras , Matthieu; Truptil , Sébastien; Fontanili , Franck; Anquetil , Anne-Ghislaine

    2016-01-01

    Part 1: Hyperconnectivity and Interoperation - Hyperconnected Systems; International audience; Internet of Things, connected devices, and other wireless sensors networks offer a number of new opportunities to manage transportation flows. This is particularly interesting for critical Supply Chains like Blood Supply Chains. In this research work, we investigate how such new technologies can enhance transportation system by better managing hazards and changes. By developing an event-driven decis...

  20. An environmentally sustainable transport system in Sweden. A scenario study

    Energy Technology Data Exchange (ETDEWEB)

    Brokking, P.; Emmelin, L.; Engstroem, M-G.; Nilsson, Jan-Evert; Eriksson, Gunnar; Wikberg, O.

    1997-02-01

    This is a short version of a scenario study concerning the possibilities to reach an Environmentally Sustainable Transport system in Sweden in a perspective of 30 years. The aim of the scenario study has been to describe one of several possible paths from today`s transport system to an environmentally adopted one. However, this does not imply that the task is to predict how such a transformation can be accomplished. The aim is rather to illustrate what such transformation require in the form of political decisions. The transformation of the transport system in to an environmentally adopted one, is primarily treated as a political problem, and a political perspective has accordingly been chosen for the study. In this English version of the scenario, the carbon dioxide problem is used to illuminate the many conflicts in goals and other problem that will attend an environmental adoption of the Swedish transport system, and to highlight the analytical points of departure for the scenario study. The analysis shows that it is possible to reach the national environmental goals that characterise, with given definitions, an environmentally sustainable transport system. However, this implies many severe political decisions over a long period of time, which in turn, implies a long term national consensus about the importance to reach the overall goal. Other results the scenario points out, is the risk that a policy focused on one sector leads to `solving` a problem by moving it outside systems limitations, and the limitations on a national environmental policy: Being able to count on assistance from other countries through an environmental adoption of the transport system in the European Union or globally, would drastically facilitate the environmental adoption of the Swedish transport system, through, among other things, a more rapid technological development. This indicates the necessity of promoting issues involving transportation and the environment in international

  1. DIRECTION OF MODERNIZATION OF THE ARCTIC MARINE TRANSPORTATION SYSTEM

    Directory of Open Access Journals (Sweden)

    N. I. Komkov

    2014-01-01

    Full Text Available The article deals with the modern processes of formation and development of the marine transportation system in the Russian Arctic, analyzes its problem areas and reserves growth. Shows the status and prospects of development of cargo specialized fl eet of ice-class and icebreakers. Particular attention is paid to infrastructure, port management, port The possibility of creating special economic zones. Systematized direction of modernization of the Arctic marine transportation system.

  2. Wind turbines application for energy savings in Gas transportation system

    OpenAIRE

    Mingaleeva, Renata

    2014-01-01

    The Thesis shows the perspectives of involving renewable energy resources into the energy balance of Russia, namely the use of wind energy for the purpose of energy supply for the objects of the Russian Gas transportation system. The methodology of the wind energy technical potential calculation is designed and the wind energy technical potential assessment for onshore and offshore zones of Russia is presented. The analysis of Russian Gas transportation system in terms of energy consumption i...

  3. Highly Scalable Trip Grouping for Large Scale Collective Transportation Systems

    DEFF Research Database (Denmark)

    Gidofalvi, Gyozo; Pedersen, Torben Bach; Risch, Tore

    2008-01-01

    Transportation-related problems, like road congestion, parking, and pollution, are increasing in most cities. In order to reduce traffic, recent work has proposed methods for vehicle sharing, for example for sharing cabs by grouping "closeby" cab requests and thus minimizing transportation cost...... and utilizing cab space. However, the methods published so far do not scale to large data volumes, which is necessary to facilitate large-scale collective transportation systems, e.g., ride-sharing systems for large cities. This paper presents highly scalable trip grouping algorithms, which generalize previous...

  4. A MULTI-AGENT SYSTEM FOR FOREST TRANSPORT ACTIVITY PLANNING

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Araújo Júnior

    2017-09-01

    Full Text Available This study aims to propose and implement a conceptual model of an intelligent system in a georeferenced environment to determine the design of forest transport fleets. For this, we used a multi-agent systems based tool, which is the subject of studies of distributed artificial intelligence. The proposed model considers the use of plantation mapping (stands and forest roads, as well as information about the different vehicle transport capacities. The system was designed to adapt itself to changes that occur during the forest transport operation process, such as the modification of demanded volume or the inclusion of route restrictions used by the vehicles. For its development, we used the Java programming language associated with the LPSolve library for the optimization calculation, the JADE platform to develop agents, and the ArcGis Runtime to determine the optimal transport routes. Five agents were modelled: the transporter, controller, router, loader and unloader agents. The model is able to determine the amount of trucks among the different vehicles available that meet the demand and availability of routes, with a focus on minimizing the total costs of timber transport. The system can also rearrange itself after the transportation routes change during the process.

  5. Implementation of a virtual vascular clinic with point-of-care ultrasound in an integrated health care system.

    Science.gov (United States)

    Lin, Judith C; Crutchfield, Janelle M; Zurawski, Dana K; Stevens, Courtney

    2018-02-01

    Using secured videoconferencing technologies, telemedicine may replace traditional clinic visits, save patients' time and travel, and improve use of limited surgeon and facility resources. We report our initial experience of the remote clinical encounter (RCE) by evaluating vascular surgery patients. In this proof-of-concept pilot study, we conducted telemedicine evaluations of vascular patients at a tertiary care institution from October 2015 to August 2016. Patients were offered synchronous virtual visits from a surgical provider in lieu of an in-person visit. We used Skype for Business (Microsoft, Redmond, Wash) over secured networks for patient-provider interaction, clinical data entry in the Epic electronic medical record (Epic Systems Corporation, Verona, Wisc) for documentation, and established satellite facilities with existing vascular laboratories for imaging and laboratory testing. We evaluated feasibility, demographics, encounter type, and satisfaction of the patient through web-based questionnaires. During a 10-month period, 41 women and 14 men with an average age of 57 years (range, 29-79 years) underwent 82 RCEs. There were 43 white (78.1%), 9 black (16.3%), 1 Asian (1.8%), and 2 Middle Eastern (3.6%) patients. Diagnoses included both arterial (aneurysm, carotid, and occlusive disease) and venous (deep venous thrombosis and varicose vein) disease. Among the 82 RCEs, visit types included 15 new patients, 30 postoperative visits, and 37 follow-up visits. Ultrasound imaging was performed in conjunction with the RCE in 74 patients (90.2%). Most patients (57%) had multiple RCEs during the study period. All 55 patients responded to the satisfaction questionnaire; 91% stated that they would highly recommend a virtual physician encounter to a friend or colleague, and all of the respondents found their encounter more convenient than having a traditional office visit. All patients thought that they were able to communicate clearly with the provider, and

  6. Flow and transport in hierarchically fractured systems

    International Nuclear Information System (INIS)

    Karasaki, K.

    1993-01-01

    Preliminary results indicate that flow in the saturated zone at Yucca Mountain is controlled by fractures. A current conceptual model assumes that the flow in the fracture system can be approximately by a three-dimensionally interconnected network of linear conduits. The overall flow system of rocks at Yucca Mountain is considered to consist of hierarchically structured heterogeneous fracture systems of multiple scales. A case study suggests that it is more appropriate to use the flow parameters of the large fracture system for predicting the first arrival time, rather than using the bulk average parameters of the total system

  7. Pneumatic transport systems for TRIGA reactors

    International Nuclear Information System (INIS)

    Bolton, John A.

    1970-01-01

    Main parameters and advantages of pneumatically operated systems, primarily those operated by gas pressure are discussed. The special irradiation ends for the TRIGA reactor are described. To give some idea of the complexity of some modern systems, the author presents the large system currently operating at the National Bureau of Standards in Washington. In this system, 13 stations are located throughout the radiochemistry laboratories and three irradiation ends are located in the reactor, which is a 14-megawatt unit. The system incorporates practically every fail-safe device possible, including ball valves located on all capsule lines entering the reactor area, designed to close automatically in the event of a reactor scram, and at that time capsules within the reactor would be diverted by means of switches located on the inside of the reactor wall. The whole system is under final control of a permission control panel located in the reactor control room. Many other safety accessories of the system are described

  8. Anatomic variations in vascular and collecting systems of kidneys from deceased donors.

    Science.gov (United States)

    Costa, H C; Moreira, R J; Fukunaga, P; Fernandes, R C; Boni, R C; Matos, A C

    2011-01-01

    Nephroureterectomy for transplantation has increased owing to the greater number of deceased donors. Anatomic variations may complicate the procedure or, if unrecognized, compromise the viability of kidneys for transplantation. We reviewed 254 surgical descriptions of nephroureterectomy specimens from January 2008 to December 2009. All organs collected according by standard techniques were evaluated for age, cause of death, renal function, frequency of injury during the procedure, as well as variations in the vascular and collecting systems. The mean donor age was 42 years (range, 2-74). The mean serum creatinine was 1.2 mg/dL (range, 1.0-7.0). The causes of death were cerebrovascular cause (stroke; n = 130), traumatic brain injury (n = 81) or other cause (n = 43). Among the anatomic variations: 8.6% (n = 22) were right arterial anatomical variations: 19 cases with 2 arteries and 3 cases with 3 arteries. In 25 cases (9.8%) the identified variation was the left artery: 2 arteries (n = 23), 3 arteries (n = 1) and 4 arteries (n = 1). We observed 9.8% on right side and 1.5% on left side venous anatomic variations, including 24 cases with 2 veins on the right side and 4 cases with 2 veins on the left side. Three cases of a retroaortic left renal vein and 1 case of a retro necklace vein (anterior and posterior to the aorta). Two cases of ureteral duplication were noted on the left and 1 on the right kidney. There were 3 horseshoe and 1 pelvic kidney. In 7.5% of cases, an injury to the graft included ureteral (n = 3), arterial (n = 10), or venous (n = 6). The most common anatomic variation was arterial (17.8%). Duplication of the renal vein was more frequent on the right. The high incidences of anatomic variations require more attention in the dissection of the renal hilum to avoid an injury that may compromise the graft. Copyright © 2011 Elsevier Inc. All rights reserved.

  9. Plasma transport simulation modeling for helical confinement systems

    International Nuclear Information System (INIS)

    Yamazaki, K.; Amano, T.

    1991-08-01

    New empirical and theoretical transport models for helical confinement systems are developed based on the neoclassical transport theory including the effect of radial electric field and multi-helicity magnetic components, and the drift wave turbulence transport for electrostatic and electromagnetic modes, or the anomalous semi-empirical transport. These electron thermal diffusivities are compared with CHS (Compact Helical System) experimental data, which indicates that the central transport coefficient of the ECH plasma agrees with the neoclassical axi-symmetric value and the transport outside the half radius is anomalous. On the other hand, the transport of NBI-heated plasmas is anomalous in the whole plasma region. This anomaly is not explained by the electrostatic drift wave turbulence models in these flat-density-profile discharges. For the detailed prediction of plasma parameters in LHD (Large Helical Device), 3-D(dimensional) equilibrium/1-D transport simulations including empirical or drift wave turbulence models are carried out, which suggests that the global confinement time of LHD is determined mainly by the electron anomalous transport near the plasma edge region rather than the helical ripple transport in the core region. Even if the ripple loss can be eliminated, the increase of the global confinement is 10%. However, the rise in the central ion temperature is more than 20%. If the anomalous loss can be reduced to the half level of the present scaling, like so-called 'H-mode' of the tokamak discharge, the neoclassical ripple loss through the ion channel becomes important even in the plasma core. The 5% radial inward shift of the plasma column with respect to the major radius is effective for improving plasma confinement and raising more than 50% of the fusion product by reducing this neoclassical asymmetric ion transport loss and increasing 10% in the plasma radius. (author)

  10. Plasma transport simulation modelling for helical confinement systems

    International Nuclear Information System (INIS)

    Yamazaki, K.; Amano, T.

    1992-01-01

    New empirical and theoretical transport models for helical confinement systems are developed on the basis of the neoclassical transport theory, including the effect of the radial electric field and of multi-helicity magnetic components as well as the drift wave turbulence transport for electrostatic and electromagnetic modes or the anomalous semi-empirical transport. These electron thermal diffusivities are compared with experimental data from the Compact Helical System which indicate that the central transport coefficient of a plasma with electron cyclotron heating agrees with neoclassical axisymmetric value and the transport outside the half-radius is anomalous. On the other hand, the transport of plasmas with neutral beam injection heating is anomalous in the whole plasma region. This anomaly is not explained by the electrostatic drift wave turbulence models in these discharges with flat density profiles. For a detailed prediction of the plasma parameters in the Large Helical Device (LHD), 3-D equilibrium/1-D transport simulations including empirical or drift wave turbulence models are performed which suggest that the global confinement time of the LHD is determined mainly by the electron anomalous transport in the plasma edge region rather than by the helical ripple transport in the core region. Even if the ripple loss can be eliminated, the increase in global confinement is 10%. However, the rise in the central ion temperature is more than 20%. If the anomalous loss can be reduced to half of the value used in the present scaling, as is the case in the H-mode of tokamak discharges, the neoclassical ripple loss through the ion channel becomes important even in the plasma core. The 5% radial inward shift of the plasma column with respect to the major radius improves the plasma confinement and increases the fusion product by more than 50% by reducing the neoclassical asymmetric ion transport loss and increasing the plasma radius (10%). (author). 32 refs, 7 figs

  11. Workshop on technology issues of superconducting Maglev transportation systems

    International Nuclear Information System (INIS)

    Wegrzyn, J.E.; Shaw, D.T.

    1991-01-01

    There exists a critical need in the United States to improve its ground transportation system. One suggested system that offers many advantages over the current transportation infrastructure is Maglev. Maglev represents the latest evolution in very high and speed ground transportation, where vehicles are magnetically levitated, guided, and propelled over elevated guideways at speeds of 300 miles per hour. Maglev is not a new concept but is, however, receiving renewed interest. The objective of this workshop was to further promote these interest by bringing together a small group of specialists in Maglev technology to discuss Maglev research needs and to identify key research issues to the development of a successful Maglev system. The workshop was organized into four sessions based on the following technical areas: Materials, Testing, and Shielding; Magnet Design and Cryogenic Systems; Propulsion and Levitation Systems; and, System Control and Integration

  12. Underground transportation and handling system for Pollux-casks

    International Nuclear Information System (INIS)

    Schrimpf, C.

    1988-01-01

    The concept for the underground transportation and handling system for Pollux-casks was optimized in a first phase by dividing the process in the repository up into the several transportation and manipulation steps. For each step, the possibilities were described and evaluated by means of a list of criteria (technical, safety and economical criteria). The following concept for the transportation and handling was developed: The casks are transported to the unloading area of the surface facilities by railway or truck. After removal of the transport protection, the entry control is performed. The cask is lifted from the vehicle and placed on a railbound transportation vehicle. This transport unit is transferred to the shaft and placed there ready for shaft hoisting. With the hoisting cage protruding, the transport unit is placed on the hoisting cage by means of a pushing-on device, locked, and then conveyed underground. After arrival on the emplacement level, the transport unit is pulled-off from the hoisting cage and taken over by a mine locomotive and transferred through the transportation and access drifts as far as to the emplacement site. There the locomotive pushed the rail transport vehicle into the emplacement drift, as far as to the designated emplacement position. At the emplacement position, the cask is again lifted by means of hoisting equipment. The rail transport vehicle is pulled out of the emplacement drift and returned to the surface for reloading. After deposition of the cask on the drift floor, the emplacement equipment is pulled back in order to give the operation space free for the slinger backfill truck. Within preceding tests two different backfilling techniques were investigated under realistic conditions: pneumatic backfilling and slinger backfilling. The slinger truck was found to be the most suitable for the designated purpose

  13. [From Bonghan system to primo vascular system:the thought on the substantial study on meridian points].

    Science.gov (United States)

    Lin, Dong; Huang, Xiaozhen; Zhuang, Wanyu; Lin, Lili

    2017-01-12

    Through the systematic analysis on the primo vascular system (PVS) in recent years, we believe that in recent years, more and more studies have indicated that PVS is distributed in reticulate structure in every part of body, such as vessels, lymphangions, nerves, brain, spinal cords and internal organs, and it contains a large amount of immunocytes and has involved in the physiological or pathological process of the immunity and circulation in the body. There are the evidences to prove that in morphology and cytobiology. But, nowadays, there is no way to explain its effect characters. On the basis of the study on living matter characteristics, a breakthrough is possibly made through the systematic cooperation even though it is the difficulty to detect the life function effect. It is especially displayed in the substantial study on meridian points. Hence, the study on the law of meridian point effects on the basis of clinical practice has to be focused on in the substantial study on meridian points.

  14. A Multilayer perspective for the analysis of urban transportation systems.

    Science.gov (United States)

    Aleta, Alberto; Meloni, Sandro; Moreno, Yamir

    2017-03-15

    Public urban mobility systems are composed by several transportation modes connected together. Most studies in urban mobility and planning often ignore the multi-layer nature of transportation systems considering only aggregated versions of this complex scenario. In this work we present a model for the representation of the transportation system of an entire city as a multiplex network. Using two different perspectives, one in which each line is a layer and one in which lines of the same transportation mode are grouped together, we study the interconnected structure of 9 different cities in Europe raging from small towns to mega-cities like London and Berlin highlighting their vulnerabilities and possible improvements. Finally, for the city of Zaragoza in Spain, we also consider data about service schedule and waiting times, which allow us to create a simple yet realistic model for urban mobility able to reproduce real-world facts and to test for network improvements.

  15. Toward a Shared Urban Transport System Ensuring Passengers & Goods Cohabitation

    Directory of Open Access Journals (Sweden)

    Anna Trentini

    2010-07-01

    Full Text Available The paper presents radical new urban transportation system concepts, potentially allowing changing the economic and environmental costs of passenger and freight transportation. The driver focuses on the concept of sharing, which means to make a joint use of transport resources, between passengers and goods flows. From a field observation of several existing solutions, an inductive reasoning enables us to move from a set of specific facts to establish an archetype for a radical new urban transportation system. Once the archetype defined, it is translated in real life through the example of the On Route proposal for London. The research frame of this paper is the ANR C-Goods (City Goods Operation Optimization using Decision support System project. Started in February 2009 the project involves four partners , and will end on 2011.

  16. Traffic Route Modelling and Assignment with Intelligent Transport System

    Directory of Open Access Journals (Sweden)

    Kunicina Nadezhda

    2014-12-01

    Full Text Available The development of signal transmitting environment for multimodal traffic control will enhance the integration of emergency and specialized transport routing tools in usual traffic control paradigms - it is one of the opportunities offered by modern intelligent traffic control systems. The improvement of effective electric power use in public transport system is an advantage of Intelligent Transport System (ITS. The research is connected with the improvement of on-line traffic control and adaptation of special traffic lighting alternatives by ITS. The assignment of the nearest appropriate transport will be done by passenger request, but unlike information system, the transport planning is done on demand. The task can be solved with the help of modern technical methods and equipment, as well as by applying control paradigms of the distributed systems. The problem is solved with the help of calculations hyper-graph and scheduling theory. The goal of the research is to develop methods, which support scheduling of the emergency transport, using high performance computing.

  17. Organelle-localized potassium transport systems in plants.

    Science.gov (United States)

    Hamamoto, Shin; Uozumi, Nobuyuki

    2014-05-15

    Some intracellular organelles found in eukaryotes such as plants have arisen through the endocytotic engulfment of prokaryotic cells. This accounts for the presence of plant membrane intrinsic proteins that have homologs in prokaryotic cells. Other organelles, such as those of the endomembrane system, are thought to have evolved through infolding of the plasma membrane. Acquisition of intracellular components (organelles) in the cells supplied additional functions for survival in various natural environments. The organelles are surrounded by biological membranes, which contain membrane-embedded K(+) transport systems allowing K(+) to move across the membrane. K(+) transport systems in plant organelles act coordinately with the plasma membrane intrinsic K(+) transport systems to maintain cytosolic K(+) concentrations. Since it is sometimes difficult to perform direct studies of organellar membrane proteins in plant cells, heterologous expression in yeast and Escherichia coli has been used to elucidate the function of plant vacuole K(+) channels and other membrane transporters. The vacuole is the largest organelle in plant cells; it has an important task in the K(+) homeostasis of the cytoplasm. The initial electrophysiological measurements of K(+) transport have categorized three classes of plant vacuolar cation channels, and since then molecular cloning approaches have led to the isolation of genes for a number of K(+) transport systems. Plants contain chloroplasts, derived from photoautotrophic cyanobacteria. A novel K(+) transport system has been isolated from cyanobacteria, which may add to our understanding of K(+) flux across the thylakoid membrane and the inner membrane of the chloroplast. This chapter will provide an overview of recent findings regarding plant organellar K(+) transport proteins. Copyright © 2014 Elsevier GmbH. All rights reserved.

  18. Concept of expert system for modal split in transportation planning

    Directory of Open Access Journals (Sweden)

    Popović Maja M.

    2006-01-01

    Full Text Available The objective of this paper is to develop a concept of expert system based on the survey of experts' opinions and their experience concerning relations in modal split, on the basis of parameters of transport system demand and transport supply, defined through PT travel time and city size, i.e. mean trip length. This expert system could be of use both to experts and less experienced planners who could apply the knowledge contained in this expert system for further improvement, on operational as well as on strategic level.

  19. Planning a transportation system for US Defense Transuranic waste

    International Nuclear Information System (INIS)

    Gilbert, K.V.; Hurley, J.D.; Smith, L.J.; McFadden, M.H.; Raudenbush, M.H.; Fedie, M.L.

    1983-05-01

    The development and planning of a transportation system for US Department of Energy (USDOE) Defense Transuranic (TRU) waste has required the talents and expertise of many people. Coordination activities, design activities, fabrication, research and development, operations, and transportation are but a few of the areas around which this system is built. Due to the large number of organizations, regulations and personalities the planning task becomes extremely complex. The intent of this paper is to discuss the steps taken in planning this system, to identify the various organizations around which this system is designed, and to discuss program progress to date, scheduling, and future plans. 9 figures, 1 table

  20. Modeling and Analysis of Modal Switching in Networked Transport Systems

    International Nuclear Information System (INIS)

    Hante, Falk M.; Leugering, Guenter; Seidman, Thomas I.

    2009-01-01

    We consider networked transport systems defined on directed graphs: the dynamics on the edges correspond to solutions of transport equations with space dimension one. In addition to the graph setting, a major consideration is the introduction and propagation of discontinuities in the solutions when the system may discontinuously switch modes, naturally or as a hybrid control. This kind of switching has been extensively studied for ordinary differential equations, but not much so far for systems governed by partial differential equations. In particular, we give well-posedness results for switching as a control, both in finite horizon open loop operation and as feedback based on sensor measurements in the system

  1. On the sample transport time of a pneumatic transfer system

    International Nuclear Information System (INIS)

    Kondo, Yoshihide

    1983-01-01

    The counts accumulated in measuring system are affected by the variations in transport time of the sample on cyclic activation experiments with a mechanical sample transfer system. In use of the pneumatic transfer system, which has been set up, the transport time is variable according to the differences as follows: The form, size and weight of samples, the pneumatic pressure and so on. Comprehending the relationships between the transpot time and these variable factors is essentially important to make experiments with this transfer system. (author)

  2. A Configurable, Object-Oriented, Transportation System Software Framework

    Energy Technology Data Exchange (ETDEWEB)

    KELLY,SUZANNE M.; MYRE,JOHN W.; PRICE,MARK H.; RUSSELL,ERIC D.; SCOTT,DAN W.

    2000-08-01

    The Transportation Surety Center, 6300, has been conducting continuing research into and development of information systems for the Configurable Transportation Security and Information Management System (CTSS) project, an Object-Oriented Framework approach that uses Component-Based Software Development to facilitate rapid deployment of new systems while improving software cost containment, development reliability, compatibility, and extensibility. The direction has been to develop a Fleet Management System (FMS) framework using object-oriented technology. The goal for the current development is to provide a software and hardware environment that will demonstrate and support object-oriented development commonly in the FMS Central Command Center and Vehicle domains.

  3. Gathering Information from Transport Systems for Processing in Supply Chains

    Science.gov (United States)

    Kodym, Oldřich; Unucka, Jakub

    2016-12-01

    Paper deals with complex system for processing information from means of transport acting as parts of train (rail or road). It focuses on automated information gathering using AutoID technology, information transmission via Internet of Things networks and information usage in information systems of logistic firms for support of selected processes on MES and ERP levels. Different kinds of gathered information from whole transport chain are discussed. Compliance with existing standards is mentioned. Security of information in full life cycle is integral part of presented system. Design of fully equipped system based on synthesized functional nodes is presented.

  4. Planning a transportation system for US defense transuranic waste

    International Nuclear Information System (INIS)

    Gilbert, K.V.; Hurley, J.D.; Smith, L.J.; McFadden, M.H.; Raudenbush, M.H.; Fedie, M.L.

    1983-01-01

    The development and planning of a transportation system for US Department of Energy (USDOE) Defense Transuranic (TRU) waste has required the talents and expertise of many people. Coordination activities, design activities, fabrication, research and development, operations, and transportation are but a few of the areas around which this system is built. Due to the large number of organizations, regulations and personalities the planning task becomes extremely complex. The intent of this paper is to discuss the steps taken in planning this system, to identify the various organizations around which this system is designed, and to discuss program progress to date, scheduling, and future plans

  5. The influence of systemic hemodynamics and oxygen transport on cerebral oxygen saturation in neonates after the Norwood procedure.

    Science.gov (United States)

    Li, Jia; Zhang, Gencheng; Holtby, Helen; Guerguerian, Anne-Marie; Cai, Sally; Humpl, Tilman; Caldarone, Christopher A; Redington, Andrew N; Van Arsdell, Glen S

    2008-01-01

    Ischemic brain injury is an important morbidity in neonates after the Norwood procedure. Its relationship to systemic hemodynamic oxygen transport is poorly understood. Sixteen neonates undergoing the Norwood procedure were studied. Continuous cerebral oxygen saturation was measured by near-infrared spectroscopy. Continuous oxygen consumption was measured by respiratory mass spectrometry. Pulmonary and systemic blood flow, systemic vascular resistance, oxygen delivery, and oxygen extraction ratio were derived with measurements of arterial, and superior vena cava and pulmonary venous gases and pressures at 2- to 4-hour intervals during the first 72 hours in the intensive care unit. Mean cerebral oxygen saturation was 66% +/- 12% before the operation, reduced to 51% +/- 13% on arrival in the intensive care unit, and remained low during the first 8 hours; it increased to 56% +/- 9% at 72 hours, still significantly lower than the preoperative level (P blood flow and oxygen delivery (P blood flow (P = .001) and hemoglobin (P = .02) and negatively correlated with systemic vascular resistance (P = .003). It was not correlated with oxygen consumption (P > .05). Cerebral oxygen saturation decreased significantly in neonates during the early postoperative period after the Norwood procedure and was significantly influenced by systemic hemodynamic and metabolic events. As such, hemodynamic interventions to modify systemic oxygen transport may provide further opportunities to reduce the risk of cerebral ischemia and improve neurodevelopmental outcomes.

  6. Pulse thermal energy transport/storage system

    Science.gov (United States)

    Weislogel, Mark M.

    1992-07-07

    A pulse-thermal pump having a novel fluid flow wherein heat admitted to a closed system raises the pressure in a closed evaporator chamber while another interconnected evaporator chamber remains open. This creates a large pressure differential, and at a predetermined pressure the closed evaporator is opened and the opened evaporator is closed. This difference in pressure initiates fluid flow in the system.

  7. Relativistic Quantum Transport in Graphene Systems

    Science.gov (United States)

    2015-07-09

    dimensional Dirac material systems. 2 List of Publications 1. X. Ni, L. Huang, Y.-C. Lai, and L. M. Pecora, “Effect of chaos on relativistic quantum...development of relativistic quantum devices based on graphene or alternative two-dimensional Dirac material systems. In the project period, we studied

  8. CARDIO-VASCULAR RISK FACTORS IN ELDERLY PATIENTS WITH DISEASES OF THE STOMATOGNATHIC SYSTEM

    Directory of Open Access Journals (Sweden)

    Botez C

    2011-09-01

    Full Text Available The association between dental and cardio-vascular diseases is essential as both are highly prevalent. Finding a possible causal relation between cardiovascular disease and chronic periodontal pathology, known to cause tooth loss, is therefore essential. The existence of some risk factors, such as smoking, bacterial infections, malnutrition and nutritional deficiencies, may explain the associations observed between cardio-vascular and oral pathologies. In the case of dental diseases, acceleration of atherosclerosis is supported by the role played by infections. The study – performed between 2008-2009 – analyzed 45 cases, selected from the patients hospitalized in the Medical Clinics of the Military Hospital of Ia[i. The patients included in the study suffered from arterial hypertension (HTA, cardiac insufficiency, ischemic cardiopathy, pectoral angina and subacute infectious endocarditis. All were subjected to a stomatological examination, for establishing their dental hygiene, the stomatological diseases they had had and the treatments performed. There are several ways in which infections of the oral cavity lead to cardiovascular disease. These include: transitory bacteriemia; inflammation and vascular lesions; diet and smoking.

  9. Morphology of vascular changes in cases of delayed radiation reactions in the central nervous system

    International Nuclear Information System (INIS)

    Lohmann, U.

    1981-01-01

    In 6 autopsies, the author presents clinical and pathological - anatomic findings which are said to be a radiotherapy. According to these findings, the vascular changes in the region which had been irradiated are of special interest as important morphological substrates of a delayed radiation reaction. In the clinical picture, this is often misinterpreted as a recurrence of a tumour which, in the worst case, causes another radiotherapy. These vascular changes can remain latent for a long time until the increasing repair burden of the nerve and vascular tissue finally causes neurological and psychological failures. A simultaneous combination of the tumour recurrence and radiation reaction, which is also possible, can lead to pictures which are difficult to differentiate clinically and which can be correctly interpreted only in the autopsy. Decisive factors in the development of a delayed radiation reaction of the nerve tissue are, according to present knowledge, excessive doses in radiotherapy and/or an insufficient fractioning. As other factors which may possibly be decisive we must, in radiotherapy, consider the patient's age, chronic accompanying diseases, regenerative ability of the tissue concerned, and also a genetic disposition. (orig./MG) [de

  10. Regulation of glucose transporter protein-1 and vascular endothelial growth factor by hypoxia inducible factor 1α under hypoxic conditions in Hep-2 human cells.

    Science.gov (United States)

    Xu, Ou; Li, Xiaoming; Qu, Yongtao; Liu, Shuang; An, Jie; Wang, Maoxin; Sun, Qingjia; Zhang, Wen; Lu, Xiuying; Pi, Lihong; Zhang, Min; Shen, Yupeng

    2012-12-01

    The present study evaluated the regulation of glucose transporter protein-1 (Glut-1) and vascular endothelial growth factor (VEGF) by hypoxia inducible factor 1α (HIF-1α) under hypoxic conditions in Hep-2 human cells to explore the feasibility of these three genes as tumor markers. Hep-2 cells were cultured under hypoxic and normoxic conditions for 6, 12, 24, 36 and 48 h. The proliferation of Hep-2 cells was evaluated using an MTT assay. The protein and mRNA expression levels of HIF-1α, Glut-1 and VEGF were detected using the S-P immunocytochemical method, western blotting and reverse transcription polymerase chain reaction (RT-PCR). The results revealed that the expression levels of HIF-1α, Glut-1 and VEGF protein in Hep-2 cells were significantly elevated under hypoxic conditions compared with those under normoxic conditions over 36 h. Under hypoxic conditions, mRNA levels of HIF-1α were stable, while mRNA levels of Glut-1 and VEGF changed over time. In conclusion, Glut-1 and VEGF were upregulated by HIF-1α under hypoxic conditions in a time-dependent manner in Hep-2 cells and their co-expression serves as a tumor marker.

  11. The competitive advantage of a dual-transporter system.

    Science.gov (United States)

    Levy, Sagi; Kafri, Moshe; Carmi, Miri; Barkai, Naama

    2011-12-09

    Cells use transporters of different affinities to regulate nutrient influx. When nutrients are depleted, low-affinity transporters are replaced by high-affinity ones. High-affinity transporters are helpful when concentrations of nutrients are low, but the advantage of reducing their abundance when nutrients are abundant is less clear. When we eliminated such reduced production of the Saccharomyces cerevisiae high-affinity transporters for phosphate and zinc, the elapsed time from the initiation of the starvation program until the lack of nutrients limited growth was shortened, and recovery from starvation was delayed. The latter phenotype was rescued by constitutive activation of the starvation program. Dual-transporter systems appear to prolong preparation for starvation and to facilitate subsequent recovery, which may optimize sensing of nutrient depletion by integrating internal and external information about nutrient availability.

  12. Transportation ALARA analysis for a nuclear waste management system

    International Nuclear Information System (INIS)

    McNair, G. W.; Schneider, K.; Smith, R.I.; Ross, W.; Faletti, D.

    1988-01-01

    In planning for implementation of a safe and cost-effective transportation system, the Department of Energy (DOE) commissioned the Pacific Northwest Laboratory (PNL) to develop estimates of the radiation doses, both public and occupational, that would result from operation of a system postulated using current designs and practices. From that evaluation, PNL identified activities/operations that result in relatively high doses, proposed conceptual alternatives that would effectively reduce such exposures, and evaluated the cost-effectiveness of such alternatives. This study contains an analysis of routine operations and estimates of the public and worker radiation doses that would occur in a postulated generic reference spent fuel transportation system using both truck and rail modes. Total risks are not estimated (i.e., consideration of nonradiological or accident risks that will be the subject of future studies in the transportation systems study plan 9TSSP) are not included). The system encompasses spent fuel loading at the reactor, transportation of the fuel to and from a receiving and handling facility and unloading of the fuel at a repository. The analysis provides cost/dose trade-offs of the postulated reference system as well as selected potential alternatives to the transportation system

  13. TRANSPORT MECHANISM STUDIES OF CHITOSAN ELECTROLYTE SYSTEMS

    International Nuclear Information System (INIS)

    Navaratnam, S.; Ramesh, K.; Ramesh, S.; Sanusi, A.; Basirun, W.J.; Arof, A.K.

    2015-01-01

    ABSTRACT: Knowledge of ion-conduction mechanisms in polymers is important for designing better polymer electrolytes for electrochemical devices. In this work, chitosan-ethylene carbonate/propylene carbonate (chitosan-EC/PC) system with lithium acetate (LiCH 3 COO) and lithium triflate (LiCF 3 SO 3 ) as salts were prepared and characterized using electrochemical impedance spectroscopy to study the ion-conduction mechanism. It was found that the electrolyte system using LiCF 3 SO 3 salt had a higher ionic conductivity, greater dielectric constant and dielectric loss value compared to system using LiCH 3 COO at room temperature. Hence, it may be inferred that the system incorporated with LiCF 3 SO 3 dissociated more readily than LiCH 3 COO. Conductivity mechanism for the systems, 42 wt.% chitosan- 28 wt.% LiCF 3 SO 3 -30 wt.% EC/PC (CLT) and 42 wt.% chitosan-28 wt.% LiCH 3 COO-30 wt.% EC/PC (CLA) follows the overlapping large polaron tunneling (OLPT) model. Results show that the nature of anion size influences the ionic conduction of chitosan based polymer electrolytes. The conductivity values of the CLA system are found to be higher than that of CLT system at higher temperatures. This may be due to the vibration of bigger triflate anions would have hindered the lithium ion movements. FTIR results show that lithium ions can form complexation with polymer host which would provide a platform for ion hopping

  14. Transfer of radioactive materials in the fuel cycle. Transportation systems, transportation volume and radiation protection

    International Nuclear Information System (INIS)

    Schwarz, G.

    1997-01-01

    No other aspect of the carriage of hazardous goods has been provoking such long-lived concern in the general public and in the press during the last few years as the transport of spent nuclear fuels and high-level radioactive wastes to the storage facility at Gorleben. One reason for this controversy, besides clear-cut opposition in principal against such transfer activities, is the fact that there is an information gap, so that large parts of the population are not well informed about the relevant legal safety requirements and obligations governing such transports. The article therefore tries to fill this gap, presenting information on the number and necessity of transports of radioactive materials in the nuclear fuel cycle, the relevant scenarios, the transportation systems and packing and shielding requirements, as well as information on the radiological classification and hazardousness of waste forms. (Orig.) [de

  15. Modular transportable superconducting magnetic energy systems

    Science.gov (United States)

    Lieurance, Dennis; Kimball, Foster; Rix, Craig

    1995-04-01

    Design and cost studies were performed for the magnet components of mid-size (1-5 MWh), cold supported SMES systems using alternative configurations. The configurations studied included solenoid magnets, which required onsite assembly of the magnet system, and toroid and racetrack configurations which consisted of factory assembled modules. For each configuration, design concepts and cost information were developed for the major features of the magnet system including the conductor, electrical insulation, and structure. These studies showed that for mid-size systems, the costs of solenoid and toroid magnet configurations are comparable and that the specific configuration to be used for a given application should be based upon customer requirements such as limiting stray fields or minimizing risks in development or construction.

  16. Modular transportable superconducting magnetic Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lieurance, D.; Kimball, F.; Rix, C. [Martin Marietta Space Magnetics, San Diego, CA (United States)

    1994-12-31

    Design and cost studies were performed for the magnet components of mid-size (1-5 MWh), cold supported SMES systems using alternative configurations. The configurations studied included solenoid magnets, which required onsite assembly of the magnet system, and toroid and racetrack configurations which consisted of factory assembled modules. For each configuration, design concepts and cost information were developed for the major features of the magnet system including the conductor, electrical insulation, and structure. These studies showed that for mid-size systems, the costs of solenoid and toroid magnet configurations are comparable and that the specific configuration to be used for a given application should be based upon customer requirements such as limiting stray fields or minimizing risks in development or construction.

  17. Teaching transportation systems thinking concepts to undergraduates.

    Science.gov (United States)

    2013-05-01

    Systems thinking is thought by many academics to be a graduate level educational venture. : Many traditional educators in the engineering field argue that first a student should gain a : grounding in some traditional branch of engineering (civil and ...

  18. Geographic Names Information System (GNIS) Transportation Features

    Data.gov (United States)

    Department of Homeland Security — The Geographic Names Information System (GNIS) is the Federal standard for geographic nomenclature. The U.S. Geological Survey developed the GNIS for the U.S. Board...

  19. Earth land landing alternatives: Lunar transportation system

    Science.gov (United States)

    Meyerson, Robert

    1992-01-01

    The objectives of this study are as follows: (1) develop a landing option such that it is a viable trade option for future NASA missions; (2) provide NASA programs with solid technical support in the landing systems area; (3) develop the technical staff; and (4) advance the state of landing systems technology to apply to future NASA missions. All results are presented in viewgraph format.

  20. Transportation of juvenile tambaqui (Colossoma macropomum in a closed system

    Directory of Open Access Journals (Sweden)

    L. C. Gomes

    Full Text Available The objective of this study was to investigate the effect of density, duration and the use of additives to the water during the transportation of juvenile tambaqui (Colossoma macropomum and use of this data to establish a safe transportation protocol for the species. The tested products and dosages were: salt (1000, 2000 and 3000 mg/L, gypsum (100, 300 and 500 mg/L and benzocaine (10, 20 and 30 mg/L. Fish were transported in closed systems (plastic bag at different densities and time periods of up to 24 h. Fish survival (FS and water quality parameters were monitored immediately after transportation. The remaining fish were kept in floating cages in order to evaluate mortality which occurred up to 96 h after transportation (S96. The best fish density, additives dosages and time period of the transportation was estimated with a general linear model. The effect of the condition factor on FS and S96 was also evaluated. As expected, FS and S96 were significantly related to time and density. FS but not S96, were also were significantly related to treatment. FS with gypsum treatment was not different from controls and FS with table salt and benzocaine treatments were significantly reduced. The condition factor was not related to either FS or S96. FS was inversely correlated with carbon dioxide concentration. It was concluded that the additives did not improve fish transportation survival. Linear models were developed to predict the best transportation densities as a function of time.

  1. Vacuum system control for the Heavy Ion Transport Line

    International Nuclear Information System (INIS)

    Stattel, P.; Feigenbaum, I.; Hseuh, H.C.; Robinson, T.; Skelton, R.; Wong, V.

    1987-01-01

    The Brookhaven AGS, 807 m in circumference, and the Tandem Van de Graaff are now joined together by a transport line, 600 m in length. This now allows heavy ions from the Tandem, up to fully stripped sulfur (M = 32) to be transported into the AGS and accelerated to 15 GeV/A. With the addition of a booster between the Tandem and the AGS in the near future, heavy ions such as gold (M = 200) can be accelerated to 30 Z/A GeV/A. This paper describes the HITL (Heavy Ion Transport Line) vacuum control system design and implementation

  2. Preliminary Transportation, Aging and Disposal Canister System Performance Specification

    International Nuclear Information System (INIS)

    C.A Kouts

    2006-01-01

    This document provides specifications for selected system components of the Transportation, Aging and Disposal (TAD) canister-based system. A list of system specified components and ancillary components are included in Section 1.2. The TAD canister, in conjunction with specialized overpacks will accomplish a number of functions in the management and disposal of spent nuclear fuel. Some of these functions will be accomplished at purchaser sites where commercial spent nuclear fuel (CSNF) is stored, and some will be performed within the Office of Civilian Radioactive Waste Management (OCRWM) transportation and disposal system. This document contains only those requirements unique to applications within Department of Energy's (DOE's) system. DOE recognizes that TAD canisters may have to perform similar functions at purchaser sites. Requirements to meet reactor functions, such as on-site dry storage, handling, and loading for transportation, are expected to be similar to commercially available canister-based systems. This document is intended to be referenced in the license application for the Monitored Geologic Repository (MGR). As such, the requirements cited herein are needed for TAD system use in OCRWM's disposal system. This document contains specifications for the TAD canister, transportation overpack and aging overpack. The remaining components and equipment that are unique to the OCRWM system or for similar purchaser applications will be supplied by others

  3. Expert system aids transport regulation users

    International Nuclear Information System (INIS)

    Cheshire, R.D.; Straw, R.J.

    1990-01-01

    During late 1984 the IAEA Regulations were identified as an area of application for an expert system adviser which could offer many advantages. Over the following year some simple tests were carried out to examine its feasibility, but TRANAID did not get underway until 1986 when British Nuclear Fuels (BNFL) Corporate Management services were engaged on the product. By this time a greater choice of suitable software, in the form of expert system shells, had become available. After a number of trial systems the shell Leonardo was finally adopted for the final system. In order for TRANAID to emulate the expert it was necessary to spend time extracting and documenting the expert knowledge. This was a matter of investigating how the regulations are used and was achieved by a series of meetings including opportunity for the computer specialists to interview the regulations experts. There are several benefits in having an expert system advisor in this area. It is useful to both experienced and inexperienced users of regulations. For those who are learning to use the regulations it is an excellent training aid. For those who know the regulations but use them infrequently it can save time and provide a valuable reassurance. The adviser has enabled the expert user's know how to be captured and to be made widely available to those with less experience. (author)

  4. Road Transportable Analytical Laboratory (RTAL) system

    International Nuclear Information System (INIS)

    1994-12-01

    The problem of groundwater contamination at a large number of industrial facilities is well known. Many US Army and Department of Energy (DOE) facilities share this problem of potentially contaminated water as a result of past disposal practices associated with military and energy source development activities. A wide range of contaminants are found at certain installations encompassing industrial pollutants and military-unique materials. The US Army Biomedical Research and Development Laboratory has been conducting research for a number of years on developing better means to determine the hazards associated with exposure to these types of complex mixtures. The methods involve the use of aquatic organisms together with in vitro mutagenicity assays and analytical chemistry in an integrated biological assessment of a specific site. Integrated Biological Assessment is an important development in the Army's continuing efforts to locate, clean and monitor sites contaminated as a result of military operations. This method provides meaningful hazard data regarding whether a test medium contains low levels of industrial or military-unique contaminants. This is an important advance in determining which sites are clean and which require remediation. It provides continuing monitoring of the effectiveness of remediation operations. Engineering Computer Opteconomics (ECO), Inc. was tasked, in a collaborative Army and DOE effort, to develop a transportable Integrated Biological Assessment Laboratory Complex. This multimodular Complex is designed to be taken into remote areas to provide the necessary long-term on-site research for determining hazards from low levels of contamination in the environment. Each module of the Complex is designed to be self-sufficient, to provide a safe environment for the operators, and a controlled environment for the test organisms and related critical chemical and biological analyses

  5. Transportation

    Science.gov (United States)

    2007-01-01

    Faculty ii INDUSTRY TRAVEL Domestic Assistant Deputy Under Secretary of Defense (Transportation Policy), Washington, DC Department of...developed between the railroad and trucking industries. Railroads: Today’s seven Class I freight railroad systems move 42% of the nation’s intercity ...has been successfully employed in London to reduce congestion and observed by this industry study during its travels . It is currently being

  6. Medical expert system for assessment of coronary heart disease destabilization based on the analysis of the level of soluble vascular adhesion molecules

    Science.gov (United States)

    Serkova, Valentina K.; Pavlov, Sergey V.; Romanava, Valentina A.; Monastyrskiy, Yuriy I.; Ziepko, Sergey M.; Kuzminova, Nanaliya V.; Wójcik, Waldemar; DzierŻak, RóŻa; Kalizhanova, Aliya; Kashaganova, Gulzhan

    2017-08-01

    Theoretical and practical substantiation of the possibility of the using the level of soluble vascular adhesion molecules (sVCAM) is performed. Expert system for the assessment of coronary heart disease (CHD) destabilization on the base of the analysis of soluble vascular adhesion molecules level is developed. Correlation between the increase of VCAM level and C-reactive protein (CRP) in patients with different variants of CHD progression is established. Association of chronic nonspecific vascular inflammation activation and CHD destabilization is shown. The expedience of parallel determination of sVCAM and CRP levels for diagnostics of CHD destabilization and forecast elaboration is noted.

  7. Underground transport - the American system, a British dream

    Energy Technology Data Exchange (ETDEWEB)

    Cox, P N

    1987-01-01

    Between 6 July and 2 August 1985 a study tour of various collieries and equipment manufacturers in the USA was undertaken. The purpose of this tour was to study the transport of men and materials. The study tour consisted of four detailed studies of transport systems. These were augmented by manufacturers' visits comprising factory tours, technical presentations and underground equipment appraisals. An itinerary is given in Appendix A.

  8. Safety analysis report for packaging (onsite) sample pig transport system

    International Nuclear Information System (INIS)

    MCCOY, J.C.

    1999-01-01

    This Safety Analysis Report for Packaging (SARP) provides a technical evaluation of the Sample Pig Transport System as compared to the requirements of the U.S. Department of Energy, Richland Operations Office (RL) Order 5480.1, Change 1, Chapter III. The evaluation concludes that the package is acceptable for the onsite transport of Type B, fissile excepted radioactive materials when used in accordance with this document

  9. On nonequilibrium many-body systems III: nonlinear transport theory

    International Nuclear Information System (INIS)

    Luzzi, R.; Vasconcellos, A.R.; Algarte, A.C.S.

    1986-01-01

    A nonlinear transport theory for many-body systems arbitrarily away from equilibrium, based on the nonequilibrium statistical operator (NSO) method, is presented. Nonlinear transport equations for a basis set of dynamical quantities are derived using two equivalent treatments that may be considered far reaching generalizations of the Hilbert-Chapman-Enskog method and Mori's generalized Langevin equations method. The first case is considered in some detail and the general characteristics of the theory are discussed. (Author) [pt

  10. Transportation Infrastructure and the Asia-Pacific Food System

    OpenAIRE

    Armbruster, Walter J.; Coyle, William T.

    2005-01-01

    Adequate, well maintained transportation infrastructure is a critical element of the Pacific food system in addressing challenges of rapid urbanization. Policymakers must invest either in streamlining domestic supply chains and/or in facilitating food imports through market opening measures. Economic incentives, competitive transportation and logistic services, and policy reforms, both within the borders of individual economies as well as across the Asia-Pacific region, are also necessary. Im...

  11. Safety analysis report for packaging (onsite) sample pig transport system

    Energy Technology Data Exchange (ETDEWEB)

    MCCOY, J.C.

    1999-03-16

    This Safety Analysis Report for Packaging (SARP) provides a technical evaluation of the Sample Pig Transport System as compared to the requirements of the U.S. Department of Energy, Richland Operations Office (RL) Order 5480.1, Change 1, Chapter III. The evaluation concludes that the package is acceptable for the onsite transport of Type B, fissile excepted radioactive materials when used in accordance with this document.

  12. Optimal Operation of Interdependent Power Systems and Electrified Transportation Networks

    Directory of Open Access Journals (Sweden)

    M. Hadi Amini

    2018-01-01

    Full Text Available Electrified transportation and power systems are mutually coupled networks. In this paper, a novel framework is developed for interdependent power and transportation networks. Our approach constitutes solving an iterative least cost vehicle routing process, which utilizes the communication of electrified vehicles (EVs with competing charging stations, to exchange data such as electricity price, energy demand, and time of arrival. The EV routing problem is solved to minimize the total cost of travel using the Dijkstra algorithm with the input from EVs battery management system, electricity price from charging stations, powertrain component efficiencies and transportation network traffic conditions. Through the bidirectional communication of EVs with competing charging stations, EVs’ charging demand estimation is done much more accurately. Then the optimal power flow problem is solved for the power system, to find the locational marginal price at load buses where charging stations are connected. Finally, the electricity prices were communicated from the charging stations to the EVs, and the loop is closed. Locational electricity price acts as the shared parameter between the two optimization problems, i.e., optimal power flow and optimal routing problem. Electricity price depends on the power demand, which is affected by the charging of EVs. On the other hand, location of EV charging stations and their different pricing strategies might affect the routing decisions of the EVs. Our novel approach that combines the electrified transportation with power system operation, holds tremendous potential for solving electrified transportation issues and reducing energy costs. The effectiveness of the proposed approach is demonstrated using Shanghai transportation network and IEEE 9-bus test system. The results verify the cost-savings for both power system and transportation networks.

  13. City transport monitoring and routes optimal management system

    Directory of Open Access Journals (Sweden)

    V. Gargasas

    2008-06-01

    Full Text Available The article analyses the problem of further development of geographic informational systems with traffic monitoring channel (GIS-TMC in order to present the road users with effective information about the fastest (the shortest in respect of time routes and thus to improve the use of existing city transport infrastructure. To solve this task it is suggested to create dynamic (automatically updated in real time street passing duration base, for support of which a city transport monitoring system operating in real time is necessary, consisting of a network of sensors, a data collection communications system and a data processing system. In the article it is shown that to predict the street passing duration it is enough to measure speed of transport in the characteristic points of the street. Measurements of traffic density do not significantly improve accuracy of forecasting the street passing time. Analytical formulas are presented meant to forecast the street passing time.

  14. Non-rocket Earth-Moon transport system

    Science.gov (United States)

    Bolonkin, Alexander

    2003-06-01

    This paper proposes a new transportation system for travel between Earth and Moon. This transportation system uses mechanical energy transfer and requires only minimal energy, using an engine located on Earth. A cable directly connects a pole of the Earth through a drive station to the lunar surface_ The equation for an optimal equal stress cable for complex gravitational field of Earth-Moon has been derived that allows significantly lower cable masses. The required strength could be provided by cables constructed of carbon nanotubes or carbon whiskers. Some of the constraints on such a system are discussed.

  15. The Transportable Measurements Facility (TMF) System Description.

    Science.gov (United States)

    1980-05-23

    sites using different antennas, antenna/site characterization, ATCRBS-mode and DABS-mode processor evaluation, and DABS-based ATC and ATARS system...conditions met. 34 TABLE 3 TMF DATA RECORDED DURING EXPERIMENTS By Word Type 1) By Parameter Word No. of Bits Experiment Number 8 Physical Location Number of

  16. Design to nullify activity movement in heat transport systems

    International Nuclear Information System (INIS)

    Hemmings, R.L.; Barber, D.

    1975-01-01

    This article describes the methods by which designers can reduce the adverse effects of system corrosion and the resultant activation of the corrosion products in heat transport systems. The presentation will cover: a) choice of materials; b) assessment of the need of components; c) control of system chemistry; d) factors considered in sizing HTS purification systems; i) control of activation and fission products; ii) decontamination. (author)

  17. Transformations in Air Transportation Systems For the 21st Century

    Science.gov (United States)

    Holmes, Bruce J.

    2004-01-01

    Globally, our transportation systems face increasingly discomforting realities: certain of the legacy air and ground infrastructures of the 20th century will not satisfy our 21st century mobility needs. The consequence of inaction is diminished quality of life and economic opportunity for those nations unable to transform from the 20th to 21st century systems. Clearly, new thinking is required regarding business models that cater to consumers value of time, airspace architectures that enable those new business models, and technology strategies for innovating at the system-of-networks level. This lecture proposes a structured way of thinking about transformation from the legacy systems of the 20th century toward new systems for the 21st century. The comparison and contrast between the legacy systems of the 20th century and the transformed systems of the 21st century provides insights into the structure of transformation of air transportation. Where the legacy systems tend to be analog (versus digital), centralized (versus distributed), and scheduled (versus on-demand) for example, transformed 21st century systems become capable of scalability through technological, business, and policy innovations. Where air mobility in our legacy systems of the 20th century brought economic opportunity and quality of life to large service markets, transformed air mobility of the 21st century becomes more equitable available to ever-thinner and widely distributed populations. Several technological developments in the traditional aircraft disciplines as well as in communication, navigation, surveillance and information systems create new foundations for 21st thinking about air transportation. One of the technological developments of importance arises from complexity science and modern network theory. Scale-free (i.e., scalable) networks represent a promising concept space for modeling airspace system architectures, and for assessing network performance in terms of robustness

  18. The plasma membrane transport systems and adaptation to salinity.

    Science.gov (United States)

    Mansour, Mohamed Magdy F

    2014-11-15

    Salt stress represents one of the environmental challenges that drastically affect plant growth and yield. Evidence suggests that glycophytes and halophytes have a salt tolerance mechanisms working at the cellular level, and the plasma membrane (PM) is believed to be one facet of the cellular mechanisms. The responses of the PM transport proteins to salinity in contrasting species/cultivars were discussed. The review provides a comprehensive overview of the recent advances describing the crucial roles that the PM transport systems have in plant adaptation to salt. Several lines of evidence were presented to demonstrate the correlation between the PM transport proteins and adaptation of plants to high salinity. How alterations in these transport systems of the PM allow plants to cope with the salt stress was also addressed. Although inconsistencies exist in some of the information related to the responses of the PM transport proteins to salinity in different species/cultivars, their key roles in adaptation of plants to high salinity is obvious and evident, and cannot be precluded. Despite the promising results, detailed investigations at the cellular/molecular level are needed in some issues of the PM transport systems in response to salinity to further evaluate their implication in salt tolerance. Copyright © 2014 Elsevier GmbH. All rights reserved.

  19. Transportation of radioactive materials: the legislative and regulatory information system

    International Nuclear Information System (INIS)

    Fore, C.S.

    1982-03-01

    The US Department of Energy is carrying out a national program to assure the safe shipment of radioactive materials. As part of this overall effort, the Hazardous Materials Information Center of Oak Ridge National Laboratory has developed the comprehensive Legislative and Regulatory Information System, which contains information on federal-, state-, and local-level legislative and regulatory actions pertaining primarily to the shipment of radioactive materials. Specific subject areas chosen to highlight particular transportation restrictions include: (1) identification of state agency responsible for regulating transportation, (2) type of escorts required, (3) areas requiring prior notification, (4) areas requiring permits or licenses, and (5) areas totally banning transportation of all radioactive materials. Other legislative information being categorized and of immediate relevance to the transportation issues is covered under the areas of disposal, storage, and management of radioactive materials; establishment of additional regulations; emergency response regulations; moratoriums on power plant construction and siting; radiation safety and control studies; and remedial action studies. The collected information is abstracted, indexed, and input into one of the two data bases developed under this information system - Current Legislation Data Base and Historical Legislation Data Base. An appendix is included which provides a summary of the state and local laws affecting the transportation of radioactive materials throughout the United States. The Legislative and Regulatory Information System is supported by the Transportation Technology Center located at Sandia National Laboratories, Albuquerque, New Mexico

  20. Toward a shared urban transport system passengers & Goods Cohabitation

    Directory of Open Access Journals (Sweden)

    Anna Trentini

    2011-10-01

    Full Text Available The paper presents radical new urban transportation system concepts, potentially allowing changing the economic and environmental costs of passenger and freight transportation. The driver focuses on the concept of sharing, which means to make a joint use of transport resources, between passengers and goods flows. From a field observation of several existing solutions, an inductive reasoning enables us to move from a set of specific facts to establish an archetype for a radical new urban transportation system. Once the archetype defined, it is translated in real life through the example of the On Route proposal for London.The research frame of this paper is the ANR ( French National Research Agency C-Goods (City Goods Operation Optimization using Decision support System project. Started in February 2009 the project involves four partners, (The multi-disciplinary French engineer school EIGSI (Ecole d’Ingénieurs en Génie des Systèmes Industriels, the French university ENMP (Ecole Nationale Supérieure des Mines de Paris, the Poitiers Urban Community (CAP, and the consulting service Interface Transport, specialized in transport economy and will end on 2012.

  1. Transportation of radioactive materials: the legislative and regulatory information system

    Energy Technology Data Exchange (ETDEWEB)

    Fore, C.S.

    1982-03-01

    The US Department of Energy is carrying out a national program to assure the safe shipment of radioactive materials. As part of this overall effort, the Hazardous Materials Information Center of Oak Ridge National Laboratory has developed the comprehensive Legislative and Regulatory Information System, which contains information on federal-, state-, and local-level legislative and regulatory actions pertaining primarily to the shipment of radioactive materials. Specific subject areas chosen to highlight particular transportation restrictions include: (1) identification of state agency responsible for regulating transportation, (2) type of escorts required, (3) areas requiring prior notification, (4) areas requiring permits or licenses, and (5) areas totally banning transportation of all radioactive materials. Other legislative information being categorized and of immediate relevance to the transportation issues is covered under the areas of disposal, storage, and management of radioactive materials; establishment of additional regulations; emergency response regulations; moratoriums on power plant construction and siting; radiation safety and control studies; and remedial action studies. The collected information is abstracted, indexed, and input into one of the two data bases developed under this information system - Current Legislation Data Base and Historical Legislation Data Base. An appendix is included which provides a summary of the state and local laws affecting the transportation of radioactive materials throughout the United States. The Legislative and Regulatory Information System is supported by the Transportation Technology Center located at Sandia National Laboratories, Albuquerque, New Mexico.

  2. Capacity analysis of automatic transport systems in an assembly factory

    NARCIS (Netherlands)

    Zijm, W.H.M.; Lenstra, J.K.; Tijms, H.C.; Volgenant, A.

    1989-01-01

    We describe a case study concerning the capacity analysis of a completely automated transport system in a flexible assembly environment. Basically, the system is modelled as a network of queues, however, due to its complex nature, product-form network theory is not applicable. Instead, we present an

  3. Optimal configuration of an integrated power and transport system

    DEFF Research Database (Denmark)

    Juul, Nina; Meibom, Peter

    2011-01-01

    optimal investments in both power plants and vehicle technologies is presented in this article. The model includes the interactions between the power system and the transport system including the competition between flexibility measures such as hydrogen storage in combination with electrolysis, heat...... storage in combination with heat pumps and heat boilers, and plug-in electric vehicles....

  4. Lattice design of beam transport system of FELI

    International Nuclear Information System (INIS)

    Miyauchi, Y.; Koga, A.; Morii, Y.; Sato, S.; Keishi, T.; Tomimasu, T.

    1994-01-01

    A plan of lasing wide range FEL (Free Electron Laser) is in progress at FELI. For this purpose, an S-band linac accelerator system of four output energy levels is under construction. This paper describes the lattice design of its beam transport (BT) system. (author)

  5. TRANSPORT: a computer program for designing charged particle beam transport systems

    International Nuclear Information System (INIS)

    Brown, K.L.; Rothacker, F.; Carey, D.C.; Iselin, C.

    1977-05-01

    TRANSPORT is a first- and second-order matrix multiplication computer program intended for the design of static-magnetic beam transport systems. It has been in existence in various evolutionary versions since 1963. The present version, described in the manual given, includes both first- and second-order fitting capabilities. TRANSPORT will step through the beam line, element by element, calculating the properties of the beam or other quantities, described below, where requested. Therefore one of the first elements is a specification of the phase space region occupied by the beam entering the system. Magnets and intervening spaces and other elements then follow in the sequence in which they occur in the beam line. Specifications of calculations to be done or of configurations other than normal are placed in the same sequence, at the point where their effect is to be made

  6. Transportation routing analysis geographic information system -- TRAGIS, a multimodal transportation routing tool

    International Nuclear Information System (INIS)

    Johnson, P.E.

    1995-01-01

    Over 15 years ago, Oak Ridge National Laboratory (ORNL) developed two transportation routing models: HIGHWAY, which predicts truck transportation routes, and INTERLINE, which predicts rail transportation routes. Subsequent modifications have been made to enhance each of these models. Some of these changes include population density information for routes, HM-164 routing regulations for highway route controlled quantities of radioactive materials (RAM) truck shipments, and inclusion of waterway routing into INTERLINE. The AIRPORT model, developed 2 years after the HIGHWAY and INTERLINE models, serves as an emergency response tool. This model identifies the nearest airports from a designated location. Currently, the AIRPORT model is inactive. The Transportation Management Division of the US Department of Energy held a Baseline Requirements Assessment Session on the HIGHWAY, INTERLINE, and AIRPORT models in April 1994 to bring together many users of these models and other experts in the transportation routing field to discuss these models and to decide on the capabilities that needed to be added. Of the many needs discussed, the primary one was to have the network databases within a geographic information system (GIS). As a result of the Baseline Requirements Session, the development of a new GIS model has been initiated. This paper will discuss the development of the new Transportation Routing Analysis GIS (TRAGIS) model at ORNL

  7. Neuro-vascular central nervous recording/stimulating system: Using nanotechnology probes

    International Nuclear Information System (INIS)

    Llinas, Rodolfo R.; Walton, Kerry D.; Nakao, Masayuki; Hunter, Ian; Anquetil, Patrick A.

    2005-01-01

    Electrical recording from spinal cord vascular capillary bed has been achieved demonstrating that the intravascular space may be utilized as a means to address brain activity with out violating the brain parenchyma. While the initial demonstration was implemented using electrically insulated platinum electrodes in vitro, the possibility of using conducting polymer filaments is now being explored. This paper presents a set of highly possible future scenarios where the integration of electrophysiology and novel polymer technology may serve as a new approach towards basic and medical neuroscience

  8. Neuro-vascular central nervous recording/stimulating system: Using nanotechnology probes

    Energy Technology Data Exchange (ETDEWEB)

    Llinas, Rodolfo R., E-mail: llinar01@popmail.med.nyu.edu; Walton, Kerry D. [NYU School of Medicine, Department of Physiology and Neuroscience (United States); Nakao, Masayuki [University of Tokyo, Institute of Engineering Innovation (Japan); Hunter, Ian; Anquetil, Patrick A. [Massachusetts Institute of Technology, Department of Mechanical Engineering, BioInstrumentation Laboratory (United States)

    2005-06-15

    Electrical recording from spinal cord vascular capillary bed has been achieved demonstrating that the intravascular space may be utilized as a means to address brain activity with out violating the brain parenchyma. While the initial demonstration was implemented using electrically insulated platinum electrodes in vitro, the possibility of using conducting polymer filaments is now being explored. This paper presents a set of highly possible future scenarios where the integration of electrophysiology and novel polymer technology may serve as a new approach towards basic and medical neuroscience.

  9. Penile gangrene in diabetes mellitus with renal failure: A poor prognostic sign of systemic vascular calciphylaxis

    Directory of Open Access Journals (Sweden)

    Mayank Mohan Agarwal

    2007-01-01

    Full Text Available Penile gangrene associated with chronic renal failure is very uncommon. A 52-year-old man with diabetes mellitus, diffuse atherosclerosis, ischemic cardiomyopathy and end-stage renal disease presented with blackening of distal penis for 10 days. His general condition was poor and gangrene of prepuce and glans was noted. Doppler and magnetic-resonance angiography revealed bilateral internal iliac artery obstruction. He underwent trocar suprapubic cystostomy and was planned for partial penectomy. But he died of severe diabetic complications in the interim period. Penile gangrene is a manifestation of widespread vascular calcifications associated with end-stage renal disease and is a marker of poor prognosis.

  10. Intraocular and systemic levels of vascular endothelial growth factor in advanced cases of retinopathy of prematurity

    Directory of Open Access Journals (Sweden)

    Raul Velez-Montoya

    2010-08-01

    Full Text Available Raul Velez-Montoya1, Carmen Clapp2, Jose Carlos Rivera2, Gerardo Garcia-Aguirre1, Virgilio Morales-Cantón1, Jans Fromow-Guerra1, Jose Luis Guerrero-Naranjo1, Hugo Quiroz-Mercado31Retina Department Asociación para Evitar la Ceguera en México IAP, México City, México; 2Department of Cellular and Molecular Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México; 3Department of Ophthalmology, Denver Health Medical Center, University of Colorado School of Medicine, Colorado, USAPurpose: To measure vitreous, aqueous, subretinal fluid and plasma levels of vascular ­endothelial growth factor in late stages of retinopathy of prematurity.Methods: Interventional study. We enrolled patients with clinical diagnoses of bilateral stage V retinopathy of prematurity, confirmed by b-scan ultrasound and programmed for vitrectomy. During surgery we took samples from blood, aqueous, vitreous, and subretinal fluids. The vascular endothelial growth factor concentration in each sample was measured by ELISA reaction. A control sample of aqueous, vitreous and blood was taken from patients with congenital cataract programmed for phacoemulsification. For statistical analysis, a Mann–Whitney and a Wilcoxon W test was done with a significant P value of 0.05.Results: We took samples of 16 consecutive patients who met the inclusion criteria. The vascular endothelial growth factor levels in the study group were: aqueous, 76.81 ± 61.89 pg/mL; vitreous, 118.53 ± 65.87 pg/mL; subretinal fluid, 1636.58 ± 356.47 pg/mL; and plasma, 74.64 ± 43.94 pg/mL. There was a statistical difference between the study and the control group (P < 0.001 in the aqueous and vitreous samples.Conclusion: Stage 5 retinopathy of prematurity has elevated intraocular levels of vascular endothelial growth factor, which remains high despite severe retinal lesion. There was no ­statistical difference in plasma levels of the molecule between the control and study group

  11. [Telemedicine with digital video transport system].

    Science.gov (United States)

    Hahm, Joon Soo; Shimizu, Shuji; Nakashima, Naoki; Byun, Tae Jun; Lee, Hang Lak; Choi, Ho Soon; Ko, Yong; Lee, Kyeong Geun; Kim, Sun Il; Kim, Tae Eun; Yun, Jiwon; Park, Yong Jin

    2004-06-01

    The growth of technology based on internet protocol has affected on the informatics and automatic controls of medical fields. The aim of this study was to establish the telemedical educational system by developing the high quality image transfer using the DVTS (digital video transmission system) on the high-speed internet network. Using telemedicine, we were able to send surgical images not only to domestic areas but also to international area. Moreover, we could discuss the condition of surgical procedures in the operation room and seminar room. The Korean-Japan cable network (KJCN) was structured in the submarine between Busan and Fukuoka. On the other hand, the Korea advanced research network (KOREN) was used to connect between Busan and Seoul. To link the image between the Hanyang University Hospital in Seoul and Kyushu University Hospital in Japan, we started teleconference system and recorded image-streaming system with DVTS on the circumstance with IPv4 network. Two operative cases were transmitted successfully. We could keep enough bandwidth of 60 Mbps for two-line transmission. The quality of transmitted moving image had no frame loss with the rate 30 per second. The sound was also clear and the time delay was less than 0.3 sec. Our study has demonstrated the feasibility of domestic and international telemedicine. We have established an international medical network with high-quality video transmission over internet protocol. It is easy to perform, reliable, and also economical. Thus, it will be a promising tool in remote medicine for worldwide telemedical communication in the future.

  12. Engineering intracellular active transport systems as in vivo biomolecular tools.

    Energy Technology Data Exchange (ETDEWEB)

    Bachand, George David; Carroll-Portillo, Amanda

    2006-11-01

    Active transport systems provide essential functions in terms of cell physiology and metastasis. These systems, however, are also co-opted by invading viruses, enabling directed transport of the virus to and from the cell's nucleus (i.e., the site of virus replication). Based on this concept, fundamentally new approaches for interrogating and manipulating the inner workings of living cells may be achievable by co-opting Nature's active transport systems as an in vivo biomolecular tool. The overall goal of this project was to investigate the ability to engineer kinesin-based transport systems for in vivo applications, specifically the collection of effector proteins (e.g., transcriptional regulators) within single cells. In the first part of this project, a chimeric fusion protein consisting of kinesin and a single chain variable fragment (scFv) of an antibody was successfully produced through a recombinant expression system. The kinesin-scFv retained both catalytic and antigenic functionality, enabling selective capture and transport of target antigens. The incorporation of a rabbit IgG-specific scFv into the kinesin established a generalized system for functionalizing kinesin with a wide range of target-selective antibodies raised in rabbits. The second objective was to develop methods of isolating the intact microtubule network from live cells as a platform for evaluating kinesin-based transport within the cytoskeletal architecture of a cell. Successful isolation of intact microtubule networks from two distinct cell types was demonstrated using glutaraldehyde and methanol fixation methods. This work provides a platform for inferring the ability of kinesin-scFv to function in vivo, and may also serve as a three-dimensional scaffold for evaluating and exploiting kinesin-based transport for nanotechnological applications. Overall, the technology developed in this project represents a first-step in engineering active transport system for in vivo

  13. Economic model of pipeline transportation systems

    Energy Technology Data Exchange (ETDEWEB)

    Banks, W. F.

    1977-07-29

    The objective of the work reported here was to develop a model which could be used to assess the economic effects of energy-conservative technological innovations upon the pipeline industry. The model is a dynamic simulator which accepts inputs of two classes: the physical description (design parameters, fluid properties, and financial structures) of the system to be studied, and the postulated market (throughput and price) projection. The model consists of time-independent submodels: the fluidics model which simulates the physical behavior of the system, and the financial model which operates upon the output of the fluidics model to calculate the economics outputs. Any of a number of existing fluidics models can be used in addition to that developed as a part of this study. The financial model, known as the Systems, Science and Software (S/sup 3/) Financial Projection Model, contains user options whereby pipeline-peculiar characteristics can be removed and/or modified, so that the model can be applied to virtually any kind of business enterprise. The several dozen outputs are of two classes: the energetics and the economics. The energetics outputs of primary interest are the energy intensity, also called unit energy consumption, and the total energy consumed. The primary economics outputs are the long-run average cost, profit, cash flow, and return on investment.

  14. Decentralized control of multi-agent aerial transportation system

    KAUST Repository

    Toumi, Noureddine

    2017-04-01

    Autonomous aerial transportation has multiple potential applications including emergency cases and rescue missions where ground intervention may be difficult. In this context, the following work will address the control of multi-agent Vertical Take-off and Landing aircraft (VTOL) transportation system. We develop a decentralized method. The advantage of such a solution is that it can provide better maneuverability and lifting capabilities compared to existing systems. First, we consider a cooperative group of VTOLs transporting one payload. The main idea is that each agent perceive the interaction with other agents as a disturbance while assuming a negotiated motion model and imposing certain magnitude bounds on each agent. The theoretical model will be then validated using a numerical simulation illustrating the interesting features of the presented control method. Results show that under specified disturbances, the algorithm is able to guarantee the tracking with a minimal error. We describe a toolbox that has been developed for this purpose. Then, a system of multiple VTOLs lifting payloads will be studied. The algorithm assures that the VTOLs are coordinated with minimal communication. Additionally, a novel gripper design for ferrous objects is presented that enables the transportation of ferrous objects without a cable. Finally, we discuss potential connections to human in the loop transportation systems.

  15. Feasibility study for a transportation operations system cask maintenance facility

    Energy Technology Data Exchange (ETDEWEB)

    Rennich, M.J.; Medley, L.G.; Attaway, C.R.

    1991-01-01

    The US Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM) is responsible for the development of a waste management program for the disposition of spent nuclear fuel (SNF) and high-level waste (HLW). The program will include a transportation system for moving the nuclear waste from the sources to a geologic repository for permanent disposal. Specially designed casks will be used to safely transport the waste. The cask systems must be operated within limits imposed by DOE, the Nuclear Regulatory Commission (NRC), and the Department of Transportation (DOT). A dedicated facility for inspecting, testing, and maintaining the cask systems was recommended by the General Accounting Office (in 1979) as the best means of assuring their operational effectiveness and safety, as well as regulatory compliance. In November of 1987, OCRWM requested a feasibility study be made of a Cask Maintenance Facility (CMF) that would perform the required functions. 46 refs., 16 figs., 13 tabs.

  16. Storage, transportation and disposal system for used nuclear fuel assemblies

    Science.gov (United States)

    Scaglione, John M.; Wagner, John C.

    2017-01-10

    An integrated storage, transportation and disposal system for used fuel assemblies is provided. The system includes a plurality of sealed canisters and a cask sized to receive the sealed canisters in side by side relationship. The plurality of sealed canisters include an internal basket structure to receive a plurality of used fuel assemblies. The internal basket structure includes a plurality of radiation-absorbing panels and a plurality of hemispherical ribs generally perpendicular to the canister sidewall. The sealed canisters are received within the cask for storage and transportation and are removed from the cask for disposal at a designated repository. The system of the present invention allows the handling of sealed canisters separately or collectively, while allowing storage and transportation of high burnup fuel and damaged fuel to the designated repository.

  17. Development of an expert system for radioactive material transportation

    International Nuclear Information System (INIS)

    Tamanoi, K.; Ishitobi, M.; Shinohara, Y.

    1990-01-01

    An expert system to deal with radioactive material transportation was developed. This expert system is based on 'Regulations for the Safe Transport of Radioactive Material' by IAEA issued 1985. IAEA published the regulations under such environments that safety transportation has become increasingly being focused as uses of radioactive materials are more pervasive, not only in nuclear field but also in non-nuclear purposes. Attentions are payed for operators and environment to establish safety in handling radioactive materials. In the 1985 regulations, detailed categorization of radioactive materials and, correspondingly, new classification of packages are introduced. This categorization is more complicated than old regulations, leading us to develop an expert system to evaluate easily the packages categorization. (author)

  18. Automated Transportation Management System (ATMS) user's manual. Revision 1

    International Nuclear Information System (INIS)

    Smith, P.D.

    1994-01-01

    The Automated Transportation Management System (ATMS) Software User Guide (SUG) constitutes the user procedures for the ATMS System. Information in this document will be used by the user to operate the automated system. It is intended to be used as a reference manual to guide and direct the user(s) through the ATMS software product and its environment. The objectives of ATMS are as follows: to better support the Procurement function with freight rate information; to free Transportation Logistics personnel from routine activities such as the auditing and input of freight billing information; to comply with Headquarters Department of Energy-Inspector General (DOE-IG) audit findings to automate transportation management functions; to reduce the keying of data into the Shipment Mobility Accountability Collection (SMAC) database; and to provide automation for the preparing of Bill of Lading, Declaration of Dangerous Goods, Emergency Response Guide and shipping Labels using HM181 Retrieval of hazardous material table text information

  19. Feasibility study for a transportation operations system cask maintenance facility

    International Nuclear Information System (INIS)

    Rennich, M.J.; Medley, L.G.; Attaway, C.R.

    1991-01-01

    The US Department of Energy (DOE), Office of Civilian Radioactive Waste Management (OCRWM) is responsible for the development of a waste management program for the disposition of spent nuclear fuel (SNF) and high-level waste (HLW). The program will include a transportation system for moving the nuclear waste from the sources to a geologic repository for permanent disposal. Specially designed casks will be used to safely transport the waste. The cask systems must be operated within limits imposed by DOE, the Nuclear Regulatory Commission (NRC), and the Department of Transportation (DOT). A dedicated facility for inspecting, testing, and maintaining the cask systems was recommended by the General Accounting Office (in 1979) as the best means of assuring their operational effectiveness and safety, as well as regulatory compliance. In November of 1987, OCRWM requested a feasibility study be made of a Cask Maintenance Facility (CMF) that would perform the required functions. 46 refs., 16 figs., 13 tabs

  20. Outline of Synchromodal Transportation System. Annex; Verkenning Synchromodaal Transportsysteem. Bijlage

    Energy Technology Data Exchange (ETDEWEB)

    Tavasszy, L.A.; Van der Lugt, L.M. [Erasmus Universiteit Rotterdam EUR, Rotterdam (Netherlands); Janssen, G.R.; Hagdorn-van der Meijden, E. [TNO, Delft (Netherlands)

    2010-11-15

    The bundling of freight flows from multiple shippers into a synchromodal network is the key to a competitive and sustainable European transport system. Synchromodal means that by 1 or more chain management centers for a larger group of companies it is determined which modality is the most appropriate at any time for any goods in the networking infrastructure: road transport, rail transport or transport over waterways? The main question in this study was: What practical actions are required from governments and businesses in the Netherlands to realize both growth and sustainability of freight transport in the coming years through a synchromodal transportation system? This annex comprises an analysis of the environment, a survey of the policies, example of synchromodality cases, a SWOT-analysis, and elaborated conditions for synchromodality. [Dutch] De bundeling van goederen-stromen van meerdere verladers in een synchromodaal netwerk is de sleutel tot een concurrerend en duurzaam Europees goederenvervoersysteem. Synchromodaal betekent dat via 1 of meerdere ketenregiecentra voor een grotere groep van bedrijven wordt bepaald welke modaliteit op welk moment voor welke goederenstroom in het infrastructurele netwerk het beste geschikt is: weg, water of spoor? De centrale vraagstelling is: Welke praktische acties zijn er nodig van overheden en bedrijven in Nederland om de dubbelslag van groei en duurzaamheid van het goederenvervoer in de komende jaren te verwezenlijken via een synchromodaal transportsysteem? Deze bijlage bevat een Omgevingsanalyse, Beleidsinventarisatie, Voorbeeld cases synchromodaliteit, een SWOT-analyse, en een Uitwerking voorwaarden synchromodaliteit.

  1. Computer vision in roadway transportation systems: a survey

    Science.gov (United States)

    Loce, Robert P.; Bernal, Edgar A.; Wu, Wencheng; Bala, Raja

    2013-10-01

    There is a worldwide effort to apply 21st century intelligence to evolving our transportation networks. The goals of smart transportation networks are quite noble and manifold, including safety, efficiency, law enforcement, energy conservation, and emission reduction. Computer vision is playing a key role in this transportation evolution. Video imaging scientists are providing intelligent sensing and processing technologies for a wide variety of applications and services. There are many interesting technical challenges including imaging under a variety of environmental and illumination conditions, data overload, recognition and tracking of objects at high speed, distributed network sensing and processing, energy sources, as well as legal concerns. This paper presents a survey of computer vision techniques related to three key problems in the transportation domain: safety, efficiency, and security and law enforcement. A broad review of the literature is complemented by detailed treatment of a few selected algorithms and systems that the authors believe represent the state-of-the-art.

  2. Development of an analysis capability for the National Transportation System

    Energy Technology Data Exchange (ETDEWEB)

    Anson, D.; Nelson, R.

    1997-10-24

    The purpose of this report is to examine the Department of Transportation`s (DOT) National Transportation System (NTS) initiative, to document what has been learned, and to outline a National Transportation Network Analysis Capability (NTNAC) based on a ``TRANSIMS-like`` approach. This study was conducted over a two month period at the end of FY1997. The scope of the effort was carefully defined to accommodate the short time horizon and to provide focus to a very large analytical problem. The objectives were to: (1) define the NTS and the NTS problem; (2) identify problem characteristics; (3) describe an analytical solution based on the TRANSIMS approach; (4) identify data requirements and availability; (5) develop criteria for a scenario to be used in a prototype demonstration; and (6) select a scenario for the prototype demonstration.

  3. The Swedish sea transportation system for safety reasons

    International Nuclear Information System (INIS)

    Dybeck, P.

    1993-01-01

    Sweden began to design and build a sea transportation system. The ship M/S SIGYN is specially designed for transports of radioactive waste. It is a combined roll-on/roll-off and lift-on/lift-off vessel. It is built for world wide operation and with the highest requirements of two independent classification societies, Lloyds Register of Shipping and Bureau Veritas. The ship is also designed to conform to the Swedish/Finish ice class 1A. The transport cask for spent fuel, TN 17/2, and core component TN 17-CC are designed as type (B) casks and manufactured to comply with the IAEA Regulations for the Safe Transport of Radioactive Materials, 1973. (J.P.N.)

  4. Efficiency improvements in pipeline transportation systems

    Energy Technology Data Exchange (ETDEWEB)

    Banks, W. F.; Horton, J. F.

    1977-09-09

    This report identifies potential energy-conservative pipeline innovations that are most energy- and cost-effective and formulates recommendations for the R, D, and D programs needed to exploit those opportunities. From a candidate field of over twenty classes of efficiency improvements, eight systems are recommended for pursuit. Most of these possess two highly important attributes: large potential energy savings and broad applicability outside the pipeline industry. The R, D, and D program for each improvement and the recommended immediate next step are described. The eight technologies recommended for R, D, and D are gas-fired combined cycle compressor station; internally cooled internal combustion engine; methanol-coal slurry pipeline; methanol-coal slurry-fired and coal-fired engines; indirect-fired coal-burning combined-cycle pump station; fuel-cell pump station; drag-reducing additives in liquid pipelines; and internal coatings in pipelines.

  5. 78 FR 43273 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2013-07-19

    ... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration Intelligent... Intelligent Transportation Systems (ITS) Program Advisory Committee (ITS PAC) will hold a meeting on August 7..., development, and implementation of intelligent transportation systems. Through its sponsor, the ITS Joint...

  6. 75 FR 77955 - Intelligent Transportation Systems Program Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-12-14

    ... DEPARTMENT OF TRANSPORTATION Research and Innovative Technology Administration Intelligent... the Intelligent Transportation Systems (ITS) Program Advisory Committee (ITSPAC). The meeting will be... of intelligent transportation systems. Through its sponsor, the ITS Joint Program Office (JPO), the...

  7. Design, operation, and evaluation of the transportable vitrification system

    International Nuclear Information System (INIS)

    Zamecnik, J.R.; Young, S.R.; Hansen, E.K.; Whitehouse, J.C.

    1997-01-01

    The Transportable Vitrification System (TVS) is a transportable melter system designed to demonstrate the treatment of low-level and mixed hazardous and radioactive wastes such as wastewater treatment sludges, contaminated soils and incinerator ash. The TVS is a large-scale, fully integrated vitrification system consisting of melter feed preparation, melter, offgas, service, and control modules. The TVS was tested with surrogate waste at the Clemson University Environmental Systems Engineering Department's (ESED) DOE/Industry Center for Vitrification Research prior to being shipped to the DOE Oak Ridge Reservation (ORR) K-25 site for treatment of mixed waste. This testing, along with additional testing at ORR, proved that the TVS would be able to successfully treat mixed waste. These surrogate tests consistently produced glass that met the EPA Toxicity Characteristic Leaching Procedure (TCLP). Performance of the system resulted in acceptable emissions of regulated metals from the offgas system. The TVS is scheduled to begin mixed waste operations at ORR in June 1997

  8. Continuous improvement of the BNFL transport integrated management system

    International Nuclear Information System (INIS)

    Hale, J.A.

    1998-01-01

    The integrated Management System of BNFL Transport and Pacific Nuclear Transport Limited (PNTL) is subject to continuous improvement by the application of established improvement techniques adopted by BNFL. The technique currently being used is the application of a Total Quality Management (TQM) philosophy, involving the identification of key processes, benchmarking against existing measures, initiating various improvement projects and applying process changes within the Company. The measurement technique being used is based upon the European Foundation for Quality Management Model (EFQM). A major initiative was started in 1996 to include the requirements of the Environmental Management Systems standard ISO 14001 within the existing integrated management system. This resulted in additional activities added to the system, modification to some existing activities and additional training for personnel. The system was audited by a third party certification organisation, Lloyds Register Quality Assurance (LRQA), during 1997. This paper describes the arrangements to review and update the integrated management system of BNFL Transport and PNTL to include the requirements of the environmental standard ISO 14001 and it also discusses the continuous improvement process adopted by BNFL Transport. (authors)

  9. Reimbursement of radiologically guided vascular interventions within the DRG-System: What wil change?; Verguetung radiologischer Gefaessinterventionen im DRG-System: Was wird sich aendern?

    Energy Technology Data Exchange (ETDEWEB)

    Strotzer, M. [Krankenhaus Hohe Warte, Bayreuth (Germany). Abt. fuer Radiologie; Feuerbach, S. [Klinikum der Univ. Regensburg (Germany). Inst. fuer Diagnostische Radiologie; Voelk, M. [Bundeswehrkrankenhaus Ulm (Germany). Abt. Radiologie

    2004-09-01

    Purpose: To evaluate reimbursement within the DRG-system ('diagnosis-related groups') compared with traditional reimbursement for interventional therapy of hospitalized patients. Materials and Methods: Reimbursement calculation was prospectively analyzed in two respects for 30 consecutive patients who underwent percutaneous transluminal angioplasty (PTA) of the lower extremity arteries: (1) based on the DRG-system; (2) based on the traditional system. Additional evaluation was performed for five further, typical vascular procedures on the basis of real documentation and calculation data (stenting of the carotid artery, fibrinolytic therapy of basilar artery occlusion, stenting of renal artery stenosis, angioplasty of hemodialysis-shunt stenosis and aspiration thrombectomy of an infrapopliteal arterial occlusion). Results: In our hospital, the introduction of the DRG system would reduce reimbursement by approximately 1100 Euro per PTA patient. However, the other vascular radiological procedures can be expected to increase the payments by up to 4500 Euro. Conclusion: To minimize imminent reduction of reimbursement for patients with peripheral PTA, complete documentation and economical patient management is mandatory. Payment may increase significantly for patients with the other reported vascular interventional procedures. (orig.)

  10. The role of volume-sensitive ion transport systems in regulation of epithelial transport

    DEFF Research Database (Denmark)

    Hoffmann, Else Kay; Schettino, T; Marshall, W S

    2007-01-01

    This review focuses on using the knowledge on volume-sensitive transport systems in Ehrlich ascites tumour cells and NIH-3T3 cells to elucidate osmotic regulation of salt transport in epithelia. Using the intestine of the European eel (Anguilla anguilla) (an absorptive epithelium of the type...... on the apical side and the Na+/K+ ATPase, NKCC1 and a K+ channel on the basolateral side. Osmotic control of Cl- secretion across the operculum epithelium includes: (i) hyperosmotic shrinkage activation of NKCC1 via PKC, MLCK, p38, OSR1 and SPAK; (ii) deactivation of NKCC by hypotonic cell swelling...

  11. Recent developments in the Los Alamos radiation transport code system

    International Nuclear Information System (INIS)

    Forster, R.A.; Parsons, K.

    1997-01-01

    A brief progress report on updates to the Los Alamos Radiation Transport Code System (LARTCS) for solving criticality and fixed-source problems is provided. LARTCS integrates the Diffusion Accelerated Neutral Transport (DANT) discrete ordinates codes with the Monte Carlo N-Particle (MCNP) code. The LARCTS code is being developed with a graphical user interface for problem setup and analysis. Progress in the DANT system for criticality applications include a two-dimensional module which can be linked to a mesh-generation code and a faster iteration scheme. Updates to MCNP Version 4A allow statistical checks of calculated Monte Carlo results

  12. Advanced Transport Operating System (ATOPS) control display unit software description

    Science.gov (United States)

    Slominski, Christopher J.; Parks, Mark A.; Debure, Kelly R.; Heaphy, William J.

    1992-01-01

    The software created for the Control Display Units (CDUs), used for the Advanced Transport Operating Systems (ATOPS) project, on the Transport Systems Research Vehicle (TSRV) is described. Module descriptions are presented in a standardized format which contains module purpose, calling sequence, a detailed description, and global references. The global reference section includes subroutines, functions, and common variables referenced by a particular module. The CDUs, one for the pilot and one for the copilot, are used for flight management purposes. Operations performed with the CDU affects the aircraft's guidance, navigation, and display software.

  13. Thaw flow control for liquid heat transport systems

    Science.gov (United States)

    Kirpich, Aaron S.

    1989-01-01

    In a liquid metal heat transport system including a source of thaw heat for use in a space reactor power system, the thaw flow throttle or control comprises a fluid passage having forward and reverse flow sections and a partition having a plurality of bleed holes therein to enable fluid flow between the forward and reverse sections. The flow throttle is positioned in the system relatively far from the source of thaw heat.

  14. Information transport in classical statistical systems

    Science.gov (United States)

    Wetterich, C.

    2018-02-01

    For "static memory materials" the bulk properties depend on boundary conditions. Such materials can be realized by classical statistical systems which admit no unique equilibrium state. We describe the propagation of information from the boundary to the bulk by classical wave functions. The dependence of wave functions on the location of hypersurfaces in the bulk is governed by a linear evolution equation that can be viewed as a generalized Schrödinger equation. Classical wave functions obey the superposition principle, with local probabilities realized as bilinears of wave functions. For static memory materials the evolution within a subsector is unitary, as characteristic for the time evolution in quantum mechanics. The space-dependence in static memory materials can be used as an analogue representation of the time evolution in quantum mechanics - such materials are "quantum simulators". For example, an asymmetric Ising model on a Euclidean two-dimensional lattice represents the time evolution of free relativistic fermions in two-dimensional Minkowski space.

  15. An adaptive robust controller for time delay maglev transportation systems

    Science.gov (United States)

    Milani, Reza Hamidi; Zarabadipour, Hassan; Shahnazi, Reza

    2012-12-01

    For engineering systems, uncertainties and time delays are two important issues that must be considered in control design. Uncertainties are often encountered in various dynamical systems due to modeling errors, measurement noises, linearization and approximations. Time delays have always been among the most difficult problems encountered in process control. In practical applications of feedback control, time delay arises frequently and can severely degrade closed-loop system performance and in some cases, drives the system to instability. Therefore, stability analysis and controller synthesis for uncertain nonlinear time-delay systems are important both in theory and in practice and many analytical techniques have been developed using delay-dependent Lyapunov function. In the past decade the magnetic and levitation (maglev) transportation system as a new system with high functionality has been the focus of numerous studies. However, maglev transportation systems are highly nonlinear and thus designing controller for those are challenging. The main topic of this paper is to design an adaptive robust controller for maglev transportation systems with time-delay, parametric uncertainties and external disturbances. In this paper, an adaptive robust control (ARC) is designed for this purpose. It should be noted that the adaptive gain is derived from Lyapunov-Krasovskii synthesis method, therefore asymptotic stability is guaranteed.

  16. Electricity for road transport, flexible power systems and wind power

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Lars Henrik; Ravn, H.; Meibom, P. (and others)

    2011-12-15

    The aim of the project is to analyse the potential synergistic interplay that may arise between the power sector and the transport sector, if parts of the road transport energy needs are based on electricity via the utilisation of plug-in hybrid electric vehicles and pure electric vehicles. The project focuses on the technical elements in the chain that comprises: 1: The electric vehicle status, potentials and expected development. Electric batteries are in focus in this part of the analysis. 2: Analysis of plug-in hybrid electric vehicle interacting with a local grid. 3: Analysis of grid-vehicle connection systems including technical regulation options and analysis of needs for standardisation. 4: Setting up scenarios covering potential developments for utilizing electric drive trains in road transport. Period: Up to year 2030. 5: Analysis of capacity constraints in the electricity grid (transmission and distribution) as consequence of increasing electricity demand, and new flexible consumption patterns from segments in the transport sector, and as consequence of increasing capacity on wind power in the system. 6: Setting up and analysis of combined scenarios covering both the heat and power system and the transport sector. (Author)

  17. Waste Information Management System with Integrated Transportation Forecast Data

    International Nuclear Information System (INIS)

    Upadhyay, H.; Quintero, W.; Shoffner, P.; Lagos, L.

    2009-01-01

    The Waste Information Management System with Integrated Transportation Forecast Data was developed to support the Department of Energy (DOE) mandated accelerated cleanup program. The schedule compression required close coordination and a comprehensive review and prioritization of the barriers that impeded treatment and disposition of the waste streams at each site. Many issues related to site waste treatment and disposal were potential critical path issues under the accelerated schedules. In order to facilitate accelerated cleanup initiatives, waste managers at DOE field sites and at DOE Headquarters in Washington, D.C., needed timely waste forecast and transportation information regarding the volumes and types of waste that would be generated by the DOE sites over the next 40 years. Each local DOE site has historically collected, organized, and displayed site waste forecast information in separate and unique systems. However, waste and shipment information from all sites needed a common application to allow interested parties to understand and view the complete complex-wide picture. The Waste Information Management System with Integrated Transportation Forecast Data allows identification of total forecasted waste volumes, material classes, disposition sites, choke points, technological or regulatory barriers to treatment and disposal, along with forecasted waste transportation information by rail, truck and inter-modal shipments. The Applied Research Center (ARC) at Florida International University (FIU) in Miami, Florida, has deployed the web-based forecast and transportation system and is responsible for updating the waste forecast and transportation data on a regular basis to ensure the long-term viability and value of this system. (authors)

  18. THE RELATION BETWEEN DRIVER BEHAVIOR AND INTELLIGENT TRANSPORT SYSTEM

    Directory of Open Access Journals (Sweden)

    Alica Kalašová

    2017-12-01

    Full Text Available The main objective of Slovakia’s transport policy is to reduce the number of traffic accidents and increase safety on our roads. Implementation of intelligent transport systems presents one of the possibilities how to meet this goal. Acceptance of these systems by motor vehicle drivers and other road traffic participants is necessary in order for them to fulfill their purpose. Only if the drivers will accept intelligent transport systems, it is possible to flexibly and effectively manage road traffic flexibly and effectively. From the perspective of a driver it concerns, in particular, the possibility of using alternative routes when traffic accidents or other obstacles occurs on the route that would significantly affect the continuity and safety of road traffic. Thanks to these technologies, it is possible to choose the appropriate route while driving, of course based on the criterion, which the driver considers the most important during the transport from origin to destination (driving time, distance from origin to destination, fuel consumption, quality of infrastructure. Information isare provided to the driver through variable message signs or directly in the vehicle (RDS-TMC. Another advantage of intelligent transport systems is a positive impact on psychological well-being of the driver while driving. Additional information about the possible obstacles, weather conditions and dangerous situations that occur on the roads as well as alternative routes are provided to the driver well in advance. This paper is mainly focused on how the drivers perceive the influence of intelligent transport systems in Žilina region.

  19. CO-2 reduction in the Danish transportation sector. Working paper 4: Cargo transport - road pricing system

    International Nuclear Information System (INIS)

    1997-03-01

    In this paper other financial control measures than fuel prices are considered for the transportation sector. The main effect discussed is that of the road pricing system. From the point of view of the CO 2 emission there could be introduced a registration tax for trucks over 4 tons as the higher transport expenditure would tend to reduce road transport demand. EU infrastructure tax directive however recommends taxes for trucks exceeding 12 tons. Road pricing will grow within the categories of lighter trucks but it is only a minor fraction of the total truck expenditure, taking into account fuel tax, weight tax and registration tax. Insurance cost is not included in these consideration. (EG) Prepared for Trafikministeriet. 22 refs

  20. Gastric antral vascular ectasia and its clinical correlates in patients with early diffuse systemic sclerosis in the SCOT trial.

    Science.gov (United States)

    Hung, Emily W; Mayes, Maureen D; Sharif, Roozbeh; Assassi, Shervin; Machicao, Victor I; Hosing, Chitra; St Clair, E William; Furst, Daniel E; Khanna, Dinesh; Forman, Stephen; Mineishi, Shin; Phillips, Kristine; Seibold, James R; Bredeson, Christopher; Csuka, Mary Ellen; Nash, Richard A; Wener, Mark H; Simms, Robert; Ballen, Karen; Leclercq, Sharon; Storek, Jan; Goldmuntz, Ellen; Welch, Beverly; Keyes-Elstein, Lynette; Castina, Sharon; Crofford, Leslie J; Mcsweeney, Peter; Sullivan, Keith M

    2013-04-01

    To describe the prevalence and clinical correlates of endoscopic gastric antral vascular ectasia (GAVE; "watermelon stomach") in early diffuse systemic sclerosis (SSc). Subjects with early, diffuse SSc and evidence of specific internal organ involvement were considered for the Scleroderma: Cyclophosphamide Or Transplant (SCOT) trial. In the screening procedures, all patients underwent upper gastrointestinal endoscopy. Patients were then categorized into those with or without endoscopic evidence of GAVE. Demographic data, clinical disease characteristics, and autoantibody data were compared using Pearson chi-square or Student t tests. Twenty-three of 103 (22.3%) individuals were found to have GAVE on endoscopy. Although not statistically significant, anti-topoisomerase I (anti-Scl70) was detected less frequently among those with GAVE (18.8% vs 44.7%; p = 0.071). Similarly, anti-RNP antibodies (anti-U1 RNP) showed a trend to a negative association with GAVE (0 vs 18.4%; p = 0.066). There was no association between anti-RNA polymerase III and GAVE. Patients with GAVE had significantly more erythema or vascular ectasias in other parts of the stomach (26.1% vs 5.0%; p = 0.003). Endoscopic GAVE was present on screening in almost one-fourth of these highly selected patients with early and severe diffuse SSc. While anti-Scl70 and anti-U1 RNP trended toward a negative association with GAVE, there was no correlation between anti-RNA Pol III and GAVE. Patients with GAVE had a higher frequency of other gastric vascular ectasias outside the antrum, suggesting that GAVE may represent part of the spectrum of the vasculopathy in SSc.

  1. Viability of a Reusable In-Space Transportation System

    Science.gov (United States)

    Jefferies, Sharon A.; McCleskey, Carey M.; Nufer, Brian M.; Lepsch, Roger A.; Merrill, Raymond G.; North, David D.; Martin, John G.; Komar, David R.

    2015-01-01

    The National Aeronautics and Space Administration (NASA) is currently developing options for an Evolvable Mars Campaign (EMC) that expands human presence from Low Earth Orbit (LEO) into the solar system and to the surface of Mars. The Hybrid in-space transportation architecture is one option being investigated within the EMC. The architecture enables return of the entire in-space propulsion stage and habitat to cis-lunar space after a round trip to Mars. This concept of operations opens the door for a fully reusable Mars transportation system from cis-lunar space to a Mars parking orbit and back. This paper explores the reuse of in-space transportation systems, with a focus on the propulsion systems. It begins by examining why reusability should be pursued and defines reusability in space-flight context. A range of functions and enablers associated with preparing a system for reuse are identified and a vision for reusability is proposed that can be advanced and implemented as new capabilities are developed. Following this, past reusable spacecraft and servicing capabilities, as well as those currently in development are discussed. Using the Hybrid transportation architecture as an example, an assessment of the degree of reusability that can be incorporated into the architecture with current capabilities is provided and areas for development are identified that will enable greater levels of reuse in the future. Implications and implementation challenges specific to the architecture are also presented.

  2. Convergent evolution of vascular optimization in kelp (Laminariales)

    DEFF Research Database (Denmark)

    Drobnitch, Sarah Tepler; Jensen, Kaare Hartvig; Prentice, Paige

    2015-01-01

    Terrestrial plants and mammals, although separated by a great evolutionary distance, have each arrived at a highly conserved body plan in which universal allometric scaling relationships govern the anatomy of vascular networks and key functional metabolic traits. The universality of allometric...... (Phaeophyceae) are one such group—as distantly related to plants as mammals, they have convergently evolved a plant-like body plan and a specialized phloem-like transport network. To evaluate possible scaling and optimization in the kelp vascular system, we developed a model of optimized transport anatomy...... and tested it with measurements of the giant kelp, Macrocystis pyrifera, which is among the largest and most successful of macroalgae. We also evaluated three classical allometric relationships pertaining to plant vascular tissues with a diverse sampling of kelp species. Macrocystis pyrifera displays strong...

  3. Anemia and elevated systemic levels of vascular endothelial growth factor (VEGF)

    International Nuclear Information System (INIS)

    Dunst, J.; Becker, A.; Lautenschlaeger, C.; Markau, S.; Becker, H.; Fischer, K.; Haensgen, G.

    2002-01-01

    Background: Tissue hypoxia is a major stimulus for the up-regulation of vascular endothelial growth factor (VEGF). Anemia might theoretically impact on angiogenesis via impairment of tissue oxygenation. We have investigated this hypothesis in patients with solid cancers and benign diseases. Patients and methods: 49 patients with untreated locoregionally confined solid cancers of the head and neck, cervix, rectum and lung and 59 additional patients with non-malignant diseases (36 normemic patients without serious diseases and 23 patients with renal anemia) were enrolled and the impact of anemia on plasma VEGF levels were determined. VEGF was measured with a commercially available sandwich enzyme immunoassay technique. Results: Plasma levels of VEGF were 16.2±12.7 pg/ml in 36 normemic patients without malignant disease, 49,2±34.5 pg/ml in 49 patients with cancers (p [de

  4. Preliminary Study of RFID System for the LILW Transportation

    International Nuclear Information System (INIS)

    Kim, Dohyung; Lee, Unjang; Choi, Kyusup

    2008-01-01

    Radio-Frequency Identification (RFID) is an automatic identification method, relying on storing and remotely retrieving data using devices called RFID tags or transponders. In Korea, Low-to-Intermediate Level Radioactive Wastes (LILW) are planed to be disposed at Kyeonju disposal repository, and 100,000 LILW drums will be disposed for the first 10 years of disposal. Tracking of these LILW drums is one of the important parts for safe transportation. To track the LILW drums during the transport as well as storage and disposal, RFID can be the prospective method for tracking the LILW drums. In this report, RFID system is introduced to the LILW transport from the generation site to disposal site, and one possible RFID system is suggested as a preliminary study

  5. High efficiency heat transport and power conversion system for cascade

    International Nuclear Information System (INIS)

    Maya, I.; Bourque, R.F.; Creedon, R.L.; Schultz, K.R.

    1985-02-01

    The Cascade ICF reactor features a flowing blanket of solid BeO and LiAlO 2 granules with very high temperature capability (up to approx. 2300 K). The authors present here the design of a high temperature granule transport and heat exchange system, and two options for high efficiency power conversion. The centrifugal-throw transport system uses the peripheral speed imparted to the granules by the rotating chamber to effect granule transport and requires no additional equipment. The heat exchanger design is a vacuum heat transfer concept utilizing gravity-induced flow of the granules over ceramic heat exchange surfaces. A reference Brayton power cycle is presented which achieves 55% net efficiency with 1300 K peak helium temperature. A modified Field steam cycle (a hybrid Rankine/Brayton cycle) is presented as an alternate which achieves 56% net efficiency

  6. Nonlinear transport properties of non-ideal systems

    International Nuclear Information System (INIS)

    Pavlov, G A

    2009-01-01

    The theory of nonlinear transport is elaborated to determine the Burnett transport properties of non-ideal multi-element plasma and neutral systems. The procedure for the comparison of the phenomenological conservation equations of a continuous dense medium and the microscopic equations for dynamical variable operators is used for the definition of these properties. The Mori algorithm is developed to derive the equations of motion of dynamical value operators of a non-ideal system in the form of the generalized nonlinear Langevin equations. In consequence, the microscopic expressions of transport coefficients corresponding to second-order thermal disturbances (temperature, mass velocity, etc) have been found in the long wavelength and low frequency limits

  7. The transport performance evaluation system building of logistics enterprises

    Directory of Open Access Journals (Sweden)

    Xueli Wang

    2013-09-01

    Full Text Available Purpose: modern logistics has a significant role in today’s society, logistics cost accounts for 35% to 50% of total logistics costs, so it’s great significance to improve the transport performance of logistics enterprises. Design/methodology/approach: the authors select the transportation performance evaluation index of logistics enterprise, with the aid of the fuzzy theory and analytic hierarchy process (AHP, adopt the combining method of quantitative and qualitative analysis, construct the transport performance evaluation system of logistics enterprises. Findings: the choice of transport performance evaluation indicator system for Logistics enterprise is in a state of "high", which indicates the indicator selection is reasonable. Research limitations/implications: the selected indicators with experts’ subjective factors can not accurately quantify. Practical implications: it has important practical significance to promote the development of modern logistics enterprises and save social cost. Originality/value: current research methods mainly include the PDCA cycle model, key performance indicators (KPI and benchmarking method, principal component analysis method, etc. The authors for the first time with the aid of fuzzy theory and analytic hierarchy process (AHP, adopt the combining method of quantitative and qualitative research on transport performance problems.

  8. Systems of pneumatic transportation of cement and other fine ...

    African Journals Online (AJOL)

    Therefore, the operational reliability of such equipment decreases and the process of cleaning of the exhaust air becomes complicated. The solution of the problem of ... of the air expense and pressure during the design of the systems. Keywords: pneumatic transportation, fine materials. dust removal equipment, pape line.

  9. Chaotic Dynamics and Transport in Classical and Quantum Systems

    International Nuclear Information System (INIS)

    2003-01-01

    The aim of this summer school is to provide a set of extended and pedagogical lectures, on the major present-day topics in dynamical systems and statistical mechanics including applications. Some articles are dedicated to chaotic transport in plasma turbulence and to quantum chaos. This document gathers the summaries of some presentations

  10. Demands for Space Transportation Systems for the next 30 years

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Demands for Space Transportation Systems for the next 30 years. Meeting the in-house and commercial launch demand for Communication and Remote Sensing spacecraft. Payload capability enhancement for expendable launch vehicles to meet the national needs.

  11. System for calibration of SPEAR transport line toroids

    International Nuclear Information System (INIS)

    Huang, T.V.; Smith, H.; Crook, K.

    1977-01-01

    A one nanosecond pulse generator was developed for calibration of the intensity monitors (toroids) in the SPEAR transport lines. The generator, located at the toroid, is simple, low cost and resistant to radiation. The generator and its connection to the standard SLAC toroid calibration system are described

  12. Maximal load of the vitamin B12 transport system

    DEFF Research Database (Denmark)

    Lildballe, Dorte L; Mutti, Elena; Birn, Henrik

    2012-01-01

    Several studies suggest that the vitamin B12 (B12) transport system can be used for the cellular delivery of B12-conjugated drugs, also in long-term treatment Whether this strategy will affect the endogenous metabolism of B12 is not known. To study the effect of treatment with excess B12...

  13. A cost-effective Geographic Information Systems for Transportation ...

    African Journals Online (AJOL)

    A cost-effective Geographic Information Systems for Transportation (GIS-T) application for traffic congestion analyses in the Developing World. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like ...

  14. A model for radionuclide transport in the Cooling Water System

    International Nuclear Information System (INIS)

    Kahook, S.D.

    1992-08-01

    A radionuclide transport model developed to assess radiological levels in the K-reactor Cooling Water System (CWS) in the event of an inadvertent process water (PW) leakage to the cooling water (CW) in the heat exchangers (HX) is described. During and following a process water leak, the radionuclide transport model determines the time-dependent release rates of radionuclide from the cooling water system to the environment via evaporation to the atmosphere and blow-down to the Savannah River. The developed model allows for delay times associated with the transport of the cooling water radioactivity through cooling water system components. Additionally, this model simulates the time-dependent behavior of radionuclides levels in various CWS components. The developed model is incorporated into the K-reactor Cooling Tower Activity (KCTA) code. KCTA allows the accident (heat exchanger leak rate) and the cooling tower blow-down and evaporation rates to be described as time-dependent functions. Thus, the postulated leak and the consequence of the assumed leak can be modelled realistically. This model is the first of three models to be ultimately assembled to form a comprehensive Liquid Pathway Activity System (LPAS). LPAS will offer integrated formation, transport, deposition, and release estimates for radionuclides formed in a SRS facility. Process water and river water modules are forthcoming as input and downstream components, respectively, for KCTA

  15. User community development for the space transportation system/Skylab

    Science.gov (United States)

    Archer, J. L.; Beauchamp, N. A.

    1974-01-01

    The New User Function plan for identifying beneficial uses of space is described. Critical issues such as funding, manpower, and protection of user proprietary rights are discussed along with common barriers which impede the development of a user community. Studies for developing methodologies of identifying new users and uses of the space transportation system are included.

  16. Chaotic Dynamics and Transport in Classical and Quantum Systems

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    The aim of this summer school is to provide a set of extended and pedagogical lectures, on the major present-day topics in dynamical systems and statistical mechanics including applications. Some articles are dedicated to chaotic transport in plasma turbulence and to quantum chaos. This document gathers the summaries of some presentations.

  17. Transportation system of recoil nucleus by helium jet

    International Nuclear Information System (INIS)

    Cabral, S.C.; Borges, A.M.; Lemos Junior, O.F.; Auler, L.T.; Silva, A.G. da

    1981-01-01

    The transportation system of recoil nucleus by helium jet, is studied. It is used a technique aiming to put in the detection area (region of low background) the recoils, produced by nuclear reactions between target and particle beams, those produced with the help of cyclotron CV-28. (E.G.) [pt

  18. Asymptotic time dependent neutron transport in multidimensional systems

    International Nuclear Information System (INIS)

    Nagy, M.E.; Sawan, M.E.; Wassef, W.A.; El-Gueraly, L.A.

    1983-01-01

    A model which predicts the asymptotic time behavior of the neutron distribution in multi-dimensional systems is presented. The model is based on the kernel factorization method used for stationary neutron transport in a rectangular parallelepiped. The accuracy of diffusion theory in predicting the asymptotic time dependence is assessed. The use of neutron pulse experiments for predicting the diffusion parameters is also investigated

  19. Transport coefficients for dense hard-disk systems

    NARCIS (Netherlands)

    García-Rojo, R.; Luding, S.; Brey, J.J.

    2006-01-01

    A study of the transport coefficients of a system of elastic hard disks based on the use of Helfand-Einstein expressions is reported. The self-diffusion, the viscosity, and the heat conductivity are examined with averaging techniques especially appropriate for event-driven molecular dynamics

  20. Particle and heavy ion transport code system; PHITS

    International Nuclear Information System (INIS)

    Niita, Koji

    2004-01-01

    Intermediate and high energy nuclear data are strongly required in design study of many facilities such as accelerator-driven systems, intense pulse spallation neutron sources, and also in medical and space technology. There is, however, few evaluated nuclear data of intermediate and high energy nuclear reactions. Therefore, we have to use some models or systematics for the cross sections, which are essential ingredients of high energy particle and heavy ion transport code to estimate neutron yield, heat deposition and many other quantities of the transport phenomena in materials. We have developed general purpose particle and heavy ion transport Monte Carlo code system, PHITS (Particle and Heavy Ion Transport code System), based on the NMTC/JAM code by the collaboration of Tohoku University, JAERI and RIST. The PHITS has three important ingredients which enable us to calculate (1) high energy nuclear reactions up to 200 GeV, (2) heavy ion collision and its transport in material, (3) low energy neutron transport based on the evaluated nuclear data. In the PHITS, the cross sections of high energy nuclear reactions are obtained by JAM model. JAM (Jet AA Microscopic Transport Model) is a hadronic cascade model, which explicitly treats all established hadronic states including resonances and all hadron-hadron cross sections parametrized based on the resonance model and string model by fitting the available experimental data. The PHITS can describe the transport of heavy ions and their collisions by making use of JQMD and SPAR code. The JQMD (JAERI Quantum Molecular Dynamics) is a simulation code for nucleus nucleus collisions based on the molecular dynamics. The SPAR code is widely used to calculate the stopping powers and ranges for charged particles and heavy ions. The PHITS has included some part of MCNP4C code, by which the transport of low energy neutron, photon and electron based on the evaluated nuclear data can be described. Furthermore, the high energy nuclear