WorldWideScience

Sample records for valid design properties

  1. Rapid Robot Design Validation, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Energid Technologies will create a comprehensive software infrastructure for rapid validation of robot designs. The software will support push-button validation...

  2. Design for validation: An approach to systems validation

    Science.gov (United States)

    Carter, William C.; Dunham, Janet R.; Laprie, Jean-Claude; Williams, Thomas; Howden, William; Smith, Brian; Lewis, Carl M. (Editor)

    1989-01-01

    Every complex system built is validated in some manner. Computer validation begins with review of the system design. As systems became too complicated for one person to review, validation began to rely on the application of adhoc methods by many individuals. As the cost of the changes mounted and the expense of failure increased, more organized procedures became essential. Attempts at devising and carrying out those procedures showed that validation is indeed a difficult technical problem. The successful transformation of the validation process into a systematic series of formally sound, integrated steps is necessary if the liability inherent in the future digita-system-based avionic and space systems is to be minimized. A suggested framework and timetable for the transformtion are presented. Basic working definitions of two pivotal ideas (validation and system life-cyle) are provided and show how the two concepts interact. Many examples are given of past and present validation activities by NASA and others. A conceptual framework is presented for the validation process. Finally, important areas are listed for ongoing development of the validation process at NASA Langley Research Center.

  3. The design and validation of a magnetic resonance imaging-compatible device for obtaining mechanical properties of plantar soft tissue via gated acquisition.

    Science.gov (United States)

    Williams, Evan D; Stebbins, Michael J; Cavanagh, Peter R; Haynor, David R; Chu, Baocheng; Fassbind, Michael J; Isvilanonda, Vara; Ledoux, William R

    2015-10-01

    Changes in the mechanical properties of the plantar soft tissue in people with diabetes may contribute to the formation of plantar ulcers. Such ulcers have been shown to be in the causal pathway for lower extremity amputation. The hydraulic plantar soft tissue reducer (HyPSTER) was designed to measure in vivo, rate-dependent plantar soft tissue compressive force and three-dimensional deformations to help understand, predict, and prevent ulcer formation. These patient-specific values can then be used in an inverse finite element analysis to determine tissue moduli, and subsequently used in a foot model to show regions of high stress under a wide variety of loading conditions. The HyPSTER uses an actuator to drive a magnetic resonance imaging-compatible hydraulic loading platform. Pressure and actuator position were synchronized with gated magnetic resonance imaging acquisition. Achievable loading rates were slower than those found in normal walking because of a water-hammer effect (pressure wave ringing) in the hydraulic system when the actuator direction was changed rapidly. The subsequent verification tests were, therefore, performed at 0.2 Hz. The unloaded displacement accuracy of the system was within 0.31%. Compliance, presumably in the system's plastic components, caused a displacement loss of 5.7 mm during a 20-mm actuator test at 1354 N. This was accounted for with a target to actual calibration curve. The positional accuracy of the HyPSTER during loaded displacement verification tests from 3 to 9 mm against a silicone backstop was 95.9% with a precision of 98.7%. The HyPSTER generated minimal artifact in the magnetic resonance imaging scanner. Careful analysis of the synchronization of the HyPSTER and the magnetic resonance imaging scanner was performed. With some limitations, the HyPSTER provided key functionality in measuring dynamic, patient-specific plantar soft tissue mechanical properties. © IMechE 2015.

  4. Security Property Validation of the Sensor Network Encryption Protocol (SNEP

    Directory of Open Access Journals (Sweden)

    Salekul Islam

    2015-07-01

    Full Text Available Since wireless sensor networks (WSNs have been designed to be deployed in an unsecured, public environment, secured communication is really vital for their wide-spread use. Among all of the communication protocols developed for WSN, the Security Protocols for Sensor Networks (SPINS is exceptional, as it has been designed with security as a goal. SPINS is composed of two building blocks: Secure Network Encryption Protocol (SNEP and the “micro” version of the Timed Efficient Streaming Loss-tolerant Authentication (TESLA, named μTESLA. From the inception of SPINS, a number of efforts have been made to validate its security properties. In this paper, we have validated the security properties of SNEP by using an automated security protocol validation tool, named AVISPA. Using the protocol specification language, HLPSL, we model two combined scenarios—node to node key agreement and counter exchange protocols—followed by data transmission. Next, we validate the security properties of these combined protocols, using different AVISPA back-ends. AVISPA reports the models we have developed free from attacks. However, by analyzing the key distribution sub-protocol, we find one threat of a potential DoS attack that we have demonstrated by modeling in AVISPA. Finally, we propose a modification, and AVISPA reports this modified version free from the potential DoS attack.

  5. Spacecraft early design validation using formal methods

    International Nuclear Information System (INIS)

    Bozzano, Marco; Cimatti, Alessandro; Katoen, Joost-Pieter; Katsaros, Panagiotis; Mokos, Konstantinos; Nguyen, Viet Yen; Noll, Thomas; Postma, Bart; Roveri, Marco

    2014-01-01

    The size and complexity of software in spacecraft is increasing exponentially, and this trend complicates its validation within the context of the overall spacecraft system. Current validation methods are labor-intensive as they rely on manual analysis, review and inspection. For future space missions, we developed – with challenging requirements from the European space industry – a novel modeling language and toolset for a (semi-)automated validation approach. Our modeling language is a dialect of AADL and enables engineers to express the system, the software, and their reliability aspects. The COMPASS toolset utilizes state-of-the-art model checking techniques, both qualitative and probabilistic, for the analysis of requirements related to functional correctness, safety, dependability and performance. Several pilot projects have been performed by industry, with two of them having focused on the system-level of a satellite platform in development. Our efforts resulted in a significant advancement of validating spacecraft designs from several perspectives, using a single integrated system model. The associated technology readiness level increased from level 1 (basic concepts and ideas) to early level 4 (laboratory-tested)

  6. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  7. The design, validation, and performance of Grace

    Directory of Open Access Journals (Sweden)

    Ru Zhu

    2016-05-01

    Full Text Available The design, validation and performance of Grace, a GPU-accelerated micromagnetic simulation software, are presented. The software adopts C+ + Accelerated Massive Parallelism (C+ + AMP so that it runs on GPUs from various hardware vendors including NVidia, AMD and Intel. At large simulation scales, up to two orders of magnitude of speedup factor is observed, compared to CPU-based micromagnetic simulation software OOMMF. The software can run on high-end professional GPUs as well as budget personal laptops, and is free to download.

  8. Engineering Software Suite Validates System Design

    Science.gov (United States)

    2007-01-01

    EDAptive Computing Inc.'s (ECI) EDAstar engineering software tool suite, created to capture and validate system design requirements, was significantly funded by NASA's Ames Research Center through five Small Business Innovation Research (SBIR) contracts. These programs specifically developed Syscape, used to capture executable specifications of multi-disciplinary systems, and VectorGen, used to automatically generate tests to ensure system implementations meet specifications. According to the company, the VectorGen tests considerably reduce the time and effort required to validate implementation of components, thereby ensuring their safe and reliable operation. EDASHIELD, an additional product offering from ECI, can be used to diagnose, predict, and correct errors after a system has been deployed using EDASTAR -created models. Initial commercialization for EDASTAR included application by a large prime contractor in a military setting, and customers include various branches within the U.S. Department of Defense, industry giants like the Lockheed Martin Corporation, Science Applications International Corporation, and Ball Aerospace and Technologies Corporation, as well as NASA's Langley and Glenn Research Centers

  9. Guided exploration of physically valid shapes for furniture design

    KAUST Repository

    Umetani, Nobuyuki; Igarashi, Takeo; Mitra, Niloy J.

    2012-01-01

    Geometric modeling and the physical validity of shapes are traditionally considered independently. This makes creating aesthetically pleasing yet physically valid models challenging. We propose an interactive design framework for efficient

  10. Internal Validity: A Must in Research Designs

    Science.gov (United States)

    Cahit, Kaya

    2015-01-01

    In experimental research, internal validity refers to what extent researchers can conclude that changes in dependent variable (i.e. outcome) are caused by manipulations in independent variable. The causal inference permits researchers to meaningfully interpret research results. This article discusses (a) internal validity threats in social and…

  11. DESIGN AND VALIDATION OF A CARDIORESPIRATORY ...

    African Journals Online (AJOL)

    UJA

    This study aimed to validate the 10x20m test for children aged 3 to 6 years in order ... obtained adequate parameters of reliability and validity in healthy children aged 3 ... and is a determinant of cardiovascular risk in preschool children (Bürgi et al., ... (Seca 222, Hamburg, Germany), and weight (kg) that was recorded with a ...

  12. Evolution of property predictability during conceptual design

    DEFF Research Database (Denmark)

    Salonen, Mikko; Hansen, Claus Thorp; Perttula, Matti

    2005-01-01

    of design alternatives, and identify the alternative which properties are best predicted to fulfil the requirements. The objective of this paper is to study the evolution of property predictability during the early phases of design in a case study context, and reflect on the implications this may have......A product is designed with the purpose of possessing certain properties, which are prescribed as requirements in the design specification. It is a common understanding that early design work and the resulting selected design concept have a significant impact on the subsequent phases of the design...... process and on the properties of the obtained design result. However, during the early phases of design every decision and choice of solution is based on incomplete information. The nature of early design work is to formulate the design problem based on an interpretation of a need, to generate a set...

  13. Identification and Validation of ESP Teacher Competencies: A Research Design

    Science.gov (United States)

    Venkatraman, G.; Prema, P.

    2013-01-01

    The paper presents the research design used for identifying and validating a set of competencies required of ESP (English for Specific Purposes) teachers. The identification of the competencies and the three-stage validation process are also discussed. The observation of classes of ESP teachers for field-testing the validated competencies and…

  14. Validation and Design Science Research in Information Systems

    NARCIS (Netherlands)

    Sol, H G; Gonzalez, Rafael A.; Mora, Manuel

    2012-01-01

    Validation within design science research in Information Systems (DSRIS) is much debated. The relationship of validation to artifact evaluation is still not clear. This chapter aims at elucidating several components of DSRIS in relation to validation. The role of theory and theorizing are an

  15. Waste Isolation Pilot Plant design validation: Final report

    International Nuclear Information System (INIS)

    1986-10-01

    This report provides documentation of actual underground conditions encountered as they relate to the design criteria, design bases, and design configurations for the reference design of the underground openings. It includes a selection of the more essential data collected during the design validation effort and an interpretation of these data

  16. Further validation of bracket pillar design methodology

    CSIR Research Space (South Africa)

    Vieira, F

    1998-07-01

    Full Text Available Design charts for bracket pillar design were developed under a previous SIMRAC project GAP 223 to provide rock mechanics engineers with an initial estimate of bracket pillar sizes for clearly identified geological discontinuities, based on mining...

  17. Flow cytometry: design, development and experimental validation

    International Nuclear Information System (INIS)

    Seigneur, Alain

    1987-01-01

    The flow cytometry techniques allow the analysis and sorting of living biologic cells at rates above five to ten thousand events per second. After a short review, we present in this report the design and development of a 'high-tech' apparatus intended for research laboratories and the experimental results. The first part deals with the physical principles allowing morphologic and functional analysis of cells or cellular components. The measured parameters are as follows: electrical resistance pulse sizing, light scattering and fluorescence. Hydrodynamic centering is used, and in the same way, the division of a water-stream into droplets leading to electrostatic sorting of particles. The second part deals with the apparatus designed by the 'Commissariat a l'Energie Atomique' (C.E.A.) and industrialised by 'ODAM' (ATC 3000). The last part of this thesis work is the performance evaluations of this cyto-meter. The difference between the two size measurement methods are analyzed: electrical resistance pulse sizing versus small-angle light scattering. By an original optics design, high sensitivity has been reached in the fluorescence measurement: the equivalent noise corresponds to six hundred fluorescein isothiocyanate (FITC) molecules. The sorting performances have also been analyzed and the cell viability proven. (author) [fr

  18. Guided exploration of physically valid shapes for furniture design

    KAUST Repository

    Umetani, Nobuyuki

    2012-07-01

    Geometric modeling and the physical validity of shapes are traditionally considered independently. This makes creating aesthetically pleasing yet physically valid models challenging. We propose an interactive design framework for efficient and intuitive exploration of geometrically and physically valid shapes. During any geometric editing operation, the proposed system continuously visualizes the valid range of the parameter being edited. When one or more constraints are violated after an operation, the system generates multiple suggestions involving both discrete and continuous changes to restore validity. Each suggestion also comes with an editing mode that simultaneously adjusts multiple parameters in a coordinated way to maintain validity. Thus, while the user focuses on the aesthetic aspects of the design, our computational design framework helps to achieve physical realizability by providing active guidance to the user. We demonstrate our framework on plankbased furniture design with nail-joint and frictional constraints. We use our system to design a range of examples, conduct a user study, and also fabricate a physical prototype to test the validity and usefulness of the system. © 2012 ACM 0730-0301/2012/08- ART86.

  19. Validation of structural design of JHR fuel element

    International Nuclear Information System (INIS)

    Brisson, S.; Miras, G.; Le Bourdonnec, L.; Lemoine, P.; Anselmet, M.C.; Marelle, V.

    2010-01-01

    The validation of the structural design of the Jules Horowitz Reactor fuel element was made by the Finite Element Method, starting from the Computer Aided Design. The JHR fuel element is a cylindrical assembly of three sectors composed of eight rolled fuel plates. A roll-swaging process is used to join the fuel plates to three aluminium stiffeners. The hydraulic gap between each plate is 1.95 mm. The JHR fuel assembly is fastened at both ends to the upper and lower endfittings by riveting. The main stresses are essentially thermal loads, imposed on the fuel zone of the plates. These thermal loads result from the nuclear heat flux (W/cm 2 ). The mechanical loads are mainly hydraulic thrust forces. The average coolant velocity is 15 m/s. Seismic effects are also studied. The fuel assembly is entirely modelled by thin shells. The model takes into account asymmetric thermal loads which often appear in Research Reactors. The mechanics of the fuel plates vary in function of the burn up. These mechanical properties are derived from the data sets used in the MAIA code, and the validity of the structure is demonstrable at throughout the life of the fuel. Results concerning displacement are compared to functional criteria, while results concerning stress are compared to RCC-MX criteria. The results of this analysis show that the mechanical and geometrical integrity of the JHR fuel elements is respected for Operating Categories 1 and 2. This paper presents the methodology of this demonstration for the results obtained. (author)

  20. Design and validation of a comprehensive fecal incontinence questionnaire.

    Science.gov (United States)

    Macmillan, Alexandra K; Merrie, Arend E H; Marshall, Roger J; Parry, Bryan R

    2008-10-01

    Fecal incontinence can have a profound effect on quality of life. Its prevalence remains uncertain because of stigma, lack of consistent definition, and dearth of validated measures. This study was designed to develop a valid clinical and epidemiologic questionnaire, building on current literature and expertise. Patients and experts undertook face validity testing. Construct validity, criterion validity, and test-retest reliability was undertaken. Construct validity comprised factor analysis and internal consistency of the quality of life scale. The validity of known groups was tested against 77 control subjects by using regression models. Questionnaire results were compared with a stool diary for criterion validity. Test-retest reliability was calculated from repeated questionnaire completion. The questionnaire achieved good face validity. It was completed by 104 patients. The quality of life scale had four underlying traits (factor analysis) and high internal consistency (overall Cronbach alpha = 0.97). Patients and control subjects answered the questionnaire significantly differently (P validity testing. Criterion validity assessment found mean differences close to zero. Median reliability for the whole questionnaire was 0.79 (range, 0.35-1). This questionnaire compares favorably with other available instruments, although the interpretation of stool consistency requires further research. Its sensitivity to treatment still needs to be investigated.

  1. Automatic control system generation for robot design validation

    Science.gov (United States)

    Bacon, James A. (Inventor); English, James D. (Inventor)

    2012-01-01

    The specification and drawings present a new method, system and software product for and apparatus for generating a robotic validation system for a robot design. The robotic validation system for the robot design of a robotic system is automatically generated by converting a robot design into a generic robotic description using a predetermined format, then generating a control system from the generic robotic description and finally updating robot design parameters of the robotic system with an analysis tool using both the generic robot description and the control system.

  2. An exploratory sequential design to validate measures of moral emotions.

    Science.gov (United States)

    Márquez, Margarita G; Delgado, Ana R

    2017-05-01

    This paper presents an exploratory and sequential mixed methods approach in validating measures of knowledge of the moral emotions of contempt, anger and disgust. The sample comprised 60 participants in the qualitative phase when a measurement instrument was designed. Item stems, response options and correction keys were planned following the results obtained in a descriptive phenomenological analysis of the interviews. In the quantitative phase, the scale was used with a sample of 102 Spanish participants, and the results were analysed with the Rasch model. In the qualitative phase, salient themes included reasons, objects and action tendencies. In the quantitative phase, good psychometric properties were obtained. The model fit was adequate. However, some changes had to be made to the scale in order to improve the proportion of variance explained. Substantive and methodological im-plications of this mixed-methods study are discussed. Had the study used a single re-search method in isolation, aspects of the global understanding of contempt, anger and disgust would have been lost.

  3. Development and Validation of a Hypersonic Vehicle Design Tool Based On Waverider Design Technique

    Science.gov (United States)

    Dasque, Nastassja

    Methodologies for a tool capable of assisting design initiatives for practical waverider based hypersonic vehicles were developed and validated. The design space for vehicle surfaces was formed using an algorithm that coupled directional derivatives with the conservation laws to determine a flow field defined by a set of post-shock streamlines. The design space is used to construct an ideal waverider with a sharp leading edge. A blunting method was developed to modify the ideal shapes to a more practical geometry for real-world application. Empirical and analytical relations were then systematically applied to the resulting geometries to determine local pressure, skin-friction and heat flux. For the ideal portion of the geometry, flat plate relations for compressible flow were applied. For the blunted portion of the geometry modified Newtonian theory, Fay-Riddell theory and Modified Reynolds analogy were applied. The design and analysis methods were validated using analytical solutions as well as empirical and numerical data. The streamline solution for the flow field generation technique was compared with a Taylor-Maccoll solution and showed very good agreement. The relationship between the local Stanton number and skin friction coefficient with local Reynolds number along the ideal portion of the body showed good agreement with experimental data. In addition, an automated grid generation routine was formulated to construct a structured mesh around resulting geometries in preparation for Computational Fluid Dynamics analysis. The overall analysis of the waverider body using the tool was then compared to CFD studies. The CFD flow field showed very good agreement with the design space. However, the distribution of the surface properties was near CFD results but did not have great agreement.

  4. Hardmetals - microstructural design, testing and property maps

    Energy Technology Data Exchange (ETDEWEB)

    Roebuck, B; Gee, M G; Morrell, R [NPL Materials Centre, National Physical Laboratory, Teddington, Middlesex (United Kingdom)

    2001-07-01

    The production of WC/Co hardmetals and their analogues is considered a mature technology, however lately there has been new research results where the concept of microstructural design was used to produce alternatives to the conventional two-phase structure. This Industry is currently well served by a range of baseline established standards, which, if properly followed with good attention to correct quality procedures, will ensure consistent products. However, there are certain key properties such as corrosion, fatigue, impact wear or high temperature strength and toughness that are often measured but not always by standard tests methods. Microstructural design potential is reviewed, particularly the possibilities of performance improvement via changes in size, shape and distribution of the phases as well as recent developments in testing, specifically S-N fatigue and abrasive wear. Finally, the concept of property mapping is introduced as a tool for providing a framework for optimizing properties. Its utility in correlating performance properties and their relationships with microstructural parameters is evaluated. Two property maps are discussed: one where the property is plotted against a microstructural feature (microstructure property maps) such as WC grain size or Co binder phase content against coercivity or hardness and one where different properties, such as hardness and toughness are mapped against each other (comparative property maps). (nevyjel)

  5. Hardmetals - microstructural design, testing and property maps

    International Nuclear Information System (INIS)

    Roebuck, B.; Gee, M.G.; Morrell, R.

    2001-01-01

    The production of WC/Co hardmetals and their analogues is considered a mature technology, however lately there has been new research results where the concept of microstructural design was used to produce alternatives to the conventional two-phase structure. This Industry is currently well served by a range of baseline established standards, which, if properly followed with good attention to correct quality procedures, will ensure consistent products. However, there are certain key properties such as corrosion, fatigue, impact wear or high temperature strength and toughness that are often measured but not always by standard tests methods. Microstructural design potential is reviewed, particularly the possibilities of performance improvement via changes in size, shape and distribution of the phases as well as recent developments in testing, specifically S-N fatigue and abrasive wear. Finally, the concept of property mapping is introduced as a tool for providing a framework for optimizing properties. Its utility in correlating performance properties and their relationships with microstructural parameters is evaluated. Two property maps are discussed: one where the property is plotted against a microstructural feature (microstructure property maps) such as WC grain size or Co binder phase content against coercivity or hardness and one where different properties, such as hardness and toughness are mapped against each other (comparative property maps). (nevyjel)

  6. Designing and Determining Psychometric Properties of the Elder Neglect Checklist

    Directory of Open Access Journals (Sweden)

    Majideh Heravi-Karimooi

    2013-10-01

    Full Text Available Objectives: The purpose of this study was to design and determine the psychometric properties of a checklist for assessing domestic elder neglect. Methods & Materials: This study was conducted in four phases. In the first phase, the meaning of domestic elder neglect explored using the qualitative method of phenomenology. In the second phase, a checklist was created, based on the results obtained in the first phase, in conjunction with the inductions from the expert panel. In the third and fourth phases, the psychometric properties including face validity, content validity, construct validity, convergent validity, internal consistency, and Inter- rater reliability were measured. 110 elderly people participated in the this study. Results: The initial 26 item checklist designed using the results of first and second phases of study, reduced to 11 items and 2 factors including the health and care needs neglect, and neglect in providing healthy environment in the process of determining the face and content validity. Acceptable convergent validity was identified in the elder neglect checklist and care neglect scale of the domestic elder abuse questionnaire (r=0.862. The results of known groups' comparisons showed that this checklist could successfully discriminate between subgroups of elderly people in the index of re-hospitalization. The internal consistency (Kuder-Richardson Formula 20 was 0.824. Inter- rater reliability of the checklist was 0.850. Conclusion: The elder neglect checklist with 11 items appears to be a promising tool, providing reliable and valid data helping to detect neglect among elders in different settings such as clinical settings, homes and research environments by health care providers and researchers.

  7. Progress in IFMIF Engineering Validation and Engineering Design Activities

    International Nuclear Information System (INIS)

    Heidinger, R.; Knaster, J.; Matsumoto, H.; Sugimoto, M.; Mosnier, A.; Arbeiter, F.; Baluc, N.; Cara, P.; Chel, S.; Facco, A.; Favuzza, P.; Heinzel, V.; Ibarra, A.; Massaut, V.; Micciche, G.; Nitti, F.S.; Theile, J.

    2013-01-01

    Highlights: ► The IFMIF/EVEDA project has entered into the crucial phase of concluding the Interim IFMIF Engineering Design Report. ► The IFMIF plant configuration has been established with the definition of five IFMIF facilities and of their interfaces. ► Three major prototypes of the IFMIF main systems have been designed and are being manufactured, commissioned and operated. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) Engineering Design and Engineering Validation Activities (EVEDA) are being developed in a joint project in the framework of the Broader Approach (BA) Agreement between EU and Japan. This project has now entered into a crucial phase as the engineering design of IFMIF is now being formulated in a series of 3 subsequent phases for delivering an Interim IFMIF Engineering Design Report (IIEDR) by mid of 2013. Content of these phases is explained, including the plant configuration detailing the 5 IFMIF facilities and their systems. Together with the Engineering Design Activities, prototyping sub-projects are pursued in the Engineering Validation Activities which consist of the design, manufacturing and testing of the following prototypical systems: Linear IFMIF Prototype Accelerator (LIPAc), EVEDA Lithium Test Loop (ELTL), and High Flux Test Module (HFTM) with the prototypical helium cooling loop (HELOKA). Highlights are described from recent experiments in the Engineering Validation Activities

  8. Development of knowledgebase system for assisting signal validation scheme design

    International Nuclear Information System (INIS)

    Kitamura, M.; Baba, T.; Washio, T.; Sugiyama, K.

    1987-01-01

    The purpose of this study is to develop a knowledgebase system to be used as a tool for designing signal validation schemes. The outputs from the signal validation scheme can be used as; (1) auxiliary signals for detecting sensor failures, (2) inputs to advanced instrumentation such as disturbance analysis and diagnosis system or safety parameter display system, and (3) inputs to digital control systems. Conventional signal validation techniques such as comparison of redundant sensors, limit checking, and calibration tests have been employed in nuclear power plants. However, these techniques have serious drawbacks, e.g. needs for extra sensors, vulnerability to common mode failures, limited applicability to continuous monitoring, etc. To alleviate these difficulties, a new signal validation technique has been developed by using the methods called analytic redundancy and parity space. Although the new technique has been proved feasible as far as preliminary tests are concerned, further developments should be made in order to enhance its practical applicability

  9. Validation of Cloud Properties From Multiple Satellites Using CALIOP Data

    Science.gov (United States)

    Yost, Christopher R.; Minnis, Patrick; Bedka, Kristopher M.; Heck, Patrick W.; Palikonda, Rabindra; Sun-Mack, Sunny; Trepte, Qing

    2016-01-01

    The NASA Langley Satellite ClOud and Radiative Property retrieval System (SatCORPS) is routinely applied to multispectral imagery from several geostationary and polar-orbiting imagers to retrieve cloud properties for weather and climate applications. Validation of the retrievals with independent datasets is continuously ongoing in order to understand differences caused by calibration, spatial resolution, viewing geometry, and other factors. The CALIOP instrument provides a decade of detailed cloud observations which can be used to evaluate passive imager retrievals of cloud boundaries, thermodynamic phase, cloud optical depth, and water path on a global scale. This paper focuses on comparisons of CALIOP retrievals to retrievals from MODIS, VIIRS, AVHRR, GOES, SEVIRI, and MTSAT. CALIOP is particularly skilled at detecting weakly-scattering cirrus clouds with optical depths less than approx. 0.5. These clouds are often undetected by passive imagers and the effect this has on the property retrievals is discussed.

  10. Design and Validation of Affective Warning Pictorial on Cigarette Labels

    Directory of Open Access Journals (Sweden)

    Chanduen Pat-Arin

    2016-01-01

    Full Text Available The purpose of present study were to design and validate affective warning pictorials for cigarette label in Thailand. Brainstorming and survey techniques were used to collect the idea of possible warning pictorials. All ideas were grouped for finding candidated pictorials. Then, primary sixty warning pictorials were collected and equally classified into three affective warning pictorial groups as positive, neutral, and negative. Sixty Thai male engineering students participated in affective validation of warning pictorials using SAM rating. The International Affective Picture System (IAPS was used to manipulate the affective state of participants to neutral affective state before the experiments. The results revealed that all affective warning pictorials were successfully evoked target affective states on participants. After refining, thirty affective warning pictorials were provided as positive, neutral, and negative affective warning pictorials for using on cigarette labels. Implications on the affective warning pictorials design and validation.

  11. Seaworthy Quantum Key Distribution Design and Validation (SEAKEY)

    Science.gov (United States)

    2015-11-12

    polarization control and the CV state and the LO state are separated at a polarizing beam splitter . The CV state is delayed relative to the LO state, and... splitter or loss imperfections. We have identified a number of risks associated with implementing this design . The two most critical risks are: • The...Contractor Address: 10 Moulton Street, Cambridge, MA 02138 Title of the Project: Seaworthy Quantum Key Distribution Design and Validation (SEAKEY

  12. Validation of Helium Inlet Design for ITER Toroidal Field Coil

    CERN Document Server

    Boyer, C; Hamada, K; Foussat, A; Le Rest, M; Mitchell, N; Decool, P; Savary, F; Sgobba, S; Weiss, K-P

    2014-01-01

    The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA-Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb$_{3}$Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, a...

  13. Design and Validation of the Quantum Mechanics Conceptual Survey

    Science.gov (United States)

    McKagan, S. B.; Perkins, K. K.; Wieman, C. E.

    2010-01-01

    The Quantum Mechanics Conceptual Survey (QMCS) is a 12-question survey of students' conceptual understanding of quantum mechanics. It is intended to be used to measure the relative effectiveness of different instructional methods in modern physics courses. In this paper, we describe the design and validation of the survey, a process that included…

  14. Design and validation of advanced driver assistance systems

    NARCIS (Netherlands)

    Gietelink, O.J.

    2007-01-01

    This thesis presents new tools and methods for the design and validation of advanced driver assistance systems (ADASs). ADASs aim to improve driving comfort and traffic safety by assisting the driver in recognizing and reacting to potentially dangerous traffic situations. A major challenge in

  15. Validation of helium inlet design for ITER toroidal field coil

    International Nuclear Information System (INIS)

    Boyer, C.; Seo, K.; Hamada, K.; Foussat, A.; Le Rest, M.; Mitchell, N.; Decool, P.; Savary, F.; Sgobba, S.; Weiss, K.P.

    2014-01-01

    The ITER organization has performed design and its validation tests on a helium inlet structure for the ITER Toroidal Field (TF) coil under collaboration with CERN, KIT, and CEA Cadarache. Detailed structural analysis was performed in order to optimize the weld shape. A fatigue resistant design on the fillet weld between the shell covers and the jacket is an important point on the helium inlet structure. A weld filler material was selected based on tensile test at liquid helium temperature after Nb 3 Sn reaction heat treatment. To validate the design of the weld joint, fatigue tests at 7 K were performed using heat-treated butt weld samples. A pressure drop measurement of a helium inlet mock-up was performed by using nitrogen gas at room temperature in order to confirm uniform flow distribution and pressure drop characteristic. These tests have validated the helium inlet design. Based on the validation, Japanese and European Union domestic agencies, which have responsibilities of the TF coil procurement, are preparing the helium inlet mock-up for a qualification test. (authors)

  16. Spent Nuclear Fuel (SNF) Project Design Verification and Validation Process

    International Nuclear Information System (INIS)

    OLGUIN, L.J.

    2000-01-01

    This document provides a description of design verification and validation activities implemented by the Spent Nuclear Fuel (SNF) Project. During the execution of early design verification, a management assessment (Bergman, 1999) and external assessments on configuration management (Augustenburg, 1999) and testing (Loscoe, 2000) were conducted and identified potential uncertainties in the verification process. This led the SNF Chief Engineer to implement corrective actions to improve process and design products. This included Design Verification Reports (DVRs) for each subproject, validation assessments for testing, and verification of the safety function of systems and components identified in the Safety Equipment List to ensure that the design outputs were compliant with the SNF Technical Requirements. Although some activities are still in progress, the results of the DVR and associated validation assessments indicate that Project requirements for design verification are being effectively implemented. These results have been documented in subproject-specific technical documents (Table 2). Identified punch-list items are being dispositioned by the Project. As these remaining items are closed, the technical reports (Table 2) will be revised and reissued to document the results of this work

  17. Validation of Satellite Derived Cloud Properties Over the Southeastern Pacific

    Science.gov (United States)

    Ayers, J.; Minnis, P.; Zuidema, P.; Sun-Mack, S.; Palikonda, R.; Nguyen, L.; Fairall, C.

    2005-12-01

    Satellite measurements of cloud properties and the radiation budget are essential for understanding meso- and large-scale processes that determine the variability in climate over the southeastern Pacific. Of particular interest in this region is the prevalent stratocumulus cloud deck. The stratocumulus albedos are directly related to cloud microphysical properties that need to be accurately characterized in Global Climate Models (GCMs) to properly estimate the Earth's radiation budget. Meteorological observations in this region are sparse causing large uncertainties in initialized model fields. Remote sensing from satellites can provide a wealth of information about the clouds in this region, but it is vital to validate the remotely sensed parameters and to understand their relationship to other parameters that are not directly observed by the satellites. The variety of measurements from the R/V Roger Revelle during the 2003 STRATUS cruise and from the R/V Ron Brown during EPIC 2001 and the 2004 STRATUS cruises are suitable for validating and improving the interpretation of the satellite derived cloud properties. In this study, satellite-derived cloud properties including coverage, height, optical depth, and liquid water path are compared with in situ measurements taken during the EPIC and STRATUS cruises. The remotely sensed values are derived from Geostationary Operational Environmental Satellite (GOES) imager data, Moderate Resolution Imaging Spectroradiometer (MODIS) data from the Terra and Aqua satellites, and from the Visible and Infrared Scanner (VIRS) aboard the Tropical Rainfall Measuring Mission (TRMM) satellite. The products from this study will include regional monthly cloud climatologies derived from the GOES data for the 2003 and 2004 cruises as well as micro and macro physical cloud property retrievals centered over the ship tracks from MODIS and VIRS.

  18. Key Design Properties for Shipping Information Pipeline

    DEFF Research Database (Denmark)

    Jensen, Thomas; Tan, Yao-Hua

    2015-01-01

    on paper, e-mail, phone and text message, and far too costly. This paper explores the design properties for a shared information infrastructure to exchange information between all parties in the supply chain, commercial parties as well as authorities, which is called a Shipping Information Pipeline...

  19. On validation of the rain climatic zone designations for Nigeria

    Science.gov (United States)

    Obiyemi, O. O.; Ibiyemi, T. S.; Ojo, J. S.

    2017-07-01

    In this paper, validation of rain climatic zone classifications for Nigeria is presented based on global radio-climatic models by the International Telecommunication Union-Radiocommunication (ITU-R) and Crane. Rain rate estimates deduced from several ground-based measurements and those earlier estimated from the precipitation index on the Tropical Rain Measurement Mission (TRMM) were employed for the validation exercise. Although earlier classifications indicated that Nigeria falls into zones P, Q, N, and K for the ITU-R designations, and zones E and H for Crane's climatic zone designations, the results however confirmed that the rain climatic zones across Nigeria can only be classified into four, namely P, Q, M, and N for the ITU-R designations, while the designations by Crane exhibited only three zones, namely E, G, and H. The ITU-R classification was found to be more suitable for planning microwave and millimeter wave links across Nigeria. The research outcomes are vital in boosting the confidence level of system designers in using the ITU-R designations as presented in the map developed for the rain zone designations for estimating the attenuation induced by rain along satellite and terrestrial microwave links over Nigeria.

  20. Automated reasoning applications to design validation and sneak function analysis

    International Nuclear Information System (INIS)

    Stratton, R.C.

    1984-01-01

    Argonne National Laboratory (ANL) is actively involved in the LMFBR Man-Machine Integration (MMI) Safety Program. The objective of this program is to enhance the operational safety and reliability of fast-breeder reactors by optimum integration of men and machines through the application of human factors principles and control engineering to the design, operation, and the control environment. ANL is developing methods to apply automated reasoning and computerization in the validation and sneak function analysis process. This project provides the element definitions and relations necessary for an automated reasoner (AR) to reason about design validation and sneak function analysis. This project also provides a demonstration of this AR application on an Experimental Breeder Reactor-II (EBR-II) system, the Argonne Cooling System

  1. Shielding design method for LMFBR validation on the Phenix factor

    International Nuclear Information System (INIS)

    Cabrillat, J.C.; Crouzet, J.; Misrakis, J.; Salvatores, M.; Rado, V.; Palmiotti, G.

    1983-05-01

    Shielding design methods, developed at CEA for shielding calculations find a global validation by the means of Phenix power reactor (250 MWe) measurements. Particularly, the secondary sodium activation of pool type LMFBR such as Super Phenix (1200 MWe) which is subject to strict safety limitation is well calculated by the adapted scheme, i.e. a two dimension transport calculation of shielding coupled to a Monte-Carlo calculation of secondary sodium activation

  2. Initial Validation of a Technical Writing Rubric for Engineering Design

    Directory of Open Access Journals (Sweden)

    Cheryl Bodnar

    2018-02-01

    Full Text Available Engineering design serves as the capstone experience of most undergraduate engineering programs. One of the key elements of the engineering design process is the compilation of results obtained into a technical report that can be shared and distributed to interested stakeholders including industry, faculty members and other relevant parties. In an effort to expand the tools available for assessment of engineering design technical reports, this study performed an initial validation of a previously developed Technical Writing rubric. The rubric was evaluated for its reliability to measure the intended construct, inter-rater reliability and external validity in comparison to an existing generalized written communication rubric. It was found that the rubric was reliable with Cronbach’s alpha for all dimensions between 0.817 and 0.976. The inter-rater reliability for the overall instrument was also found to be excellent at 0.85. Finally, it was observed that there were no statistically significant differences observed between the measurements obtained on the Technical Writing rubric in comparison to the more generalized Written Communication Value rubric. This demonstrates that although specific to engineering design environments the Technical Writing rubric was able to measure key constructs associated with written communication practice. This rubric can now serve as one additional tool for assessment of communication skills within engineering capstone design experiences.

  3. A Simulation Approach for Performance Validation during Embedded Systems Design

    Science.gov (United States)

    Wang, Zhonglei; Haberl, Wolfgang; Herkersdorf, Andreas; Wechs, Martin

    Due to the time-to-market pressure, it is highly desirable to design hardware and software of embedded systems in parallel. However, hardware and software are developed mostly using very different methods, so that performance evaluation and validation of the whole system is not an easy task. In this paper, we propose a simulation approach to bridge the gap between model-driven software development and simulation based hardware design, by merging hardware and software models into a SystemC based simulation environment. An automated procedure has been established to generate software simulation models from formal models, while the hardware design is originally modeled in SystemC. As the simulation models are annotated with timing information, performance issues are tackled in the same pass as system functionality, rather than in a dedicated approach.

  4. Impacts of Sample Design for Validation Data on the Accuracy of Feedforward Neural Network Classification

    Directory of Open Access Journals (Sweden)

    Giles M. Foody

    2017-08-01

    Full Text Available Validation data are often used to evaluate the performance of a trained neural network and used in the selection of a network deemed optimal for the task at-hand. Optimality is commonly assessed with a measure, such as overall classification accuracy. The latter is often calculated directly from a confusion matrix showing the counts of cases in the validation set with particular labelling properties. The sample design used to form the validation set can, however, influence the estimated magnitude of the accuracy. Commonly, the validation set is formed with a stratified sample to give balanced classes, but also via random sampling, which reflects class abundance. It is suggested that if the ultimate aim is to accurately classify a dataset in which the classes do vary in abundance, a validation set formed via random, rather than stratified, sampling is preferred. This is illustrated with the classification of simulated and remotely-sensed datasets. With both datasets, statistically significant differences in the accuracy with which the data could be classified arose from the use of validation sets formed via random and stratified sampling (z = 2.7 and 1.9 for the simulated and real datasets respectively, for both p < 0.05%. The accuracy of the classifications that used a stratified sample in validation were smaller, a result of cases of an abundant class being commissioned into a rarer class. Simple means to address the issue are suggested.

  5. Validation and Application of Concentrated Cesium Eluate Physical Property Models

    International Nuclear Information System (INIS)

    Choi, A.S.

    2004-01-01

    This work contained two objectives. To verify the mathematical equations developed for the physical properties of concentrated cesium eluate solutions against experimental test results obtained with simulated feeds. To estimate the physical properties of the radioactive AW-101 cesium eluate at saturation using the validated models. The Hanford River Protection Project (RPP) Hanford Waste Treatment and Immobilization Plant (WTP) is currently being built to extract radioisotopes from the vast inventory of Hanford tank wastes and immobilize them in a silicate glass matrix for eventual disposal at a geological repository. The baseline flowsheet for the pretreatment of supernatant liquid wastes includes removal of cesium using regenerative ion-exchange resins. The loaded cesium ion-exchange columns will be eluted with nitric acid nominally at 0.5 molar, and the resulting eluate solution will be concentrated in a forced-convection evaporator to reduce the storage volume and to recover the acid for reuse. The reboiler pot is initially charged with a concentrated nitric acid solution and kept under a controlled vacuum during feeding so the pot contents would boil at 50 degrees Celsius. The liquid level in the pot is maintained constant by controlling both the feed and boilup rates. The feeding will continue with no bottom removal until the solution in the pot reaches the target endpoint of 80 per cent saturation with respect to any one of the major salt species present

  6. Improved Hypersonic Inlet Performance Using Validated Strut Compression Designs

    Science.gov (United States)

    Bulman, M. J.; Stout, P. W.; Fernandez, R.

    1997-01-01

    Aerojet is currently executing two Strutjet propulsion contracts: one a Rocket Based Combined Cycle (RBCC) engine for a NASA-Marshall Space Flight Center (MSFC) Advanced Reusable Transportation Technology (ARTT) program, the second a Dual Mode Ram/Scramjet engine for a USAF Wright Laboratories Storable Fuel Scramjet Flow Path Concepts program. The engines employed in both programs operate at supersonic and low hypersonic speeds and use inlets employing forebody external and sidewall compression. Aerojet has developed and validated a successful design methodology applicable to these inlet types. Design features include an integrated vehicle forebody, external side compression struts, strut sidewall and throat bleed, a throat shock trap, and variable geometry internal contraction. Computation Fluid Dynamic (CFD) predictions and test data show these inlets allow substantially increased flow turning angles over other designs. These increased flow turning angles allow shorter and lighter engines than current designs, which in turn enables higher performing vehicles with broad operating characteristics. This paper describes the designs of two different inlets evaluated by the NASA-MSFC and USAF programs, discusses the results of wind tunnel tests performed by NASA-Lewis Research Center, and provides correlations of test data with CFD predictions. Parameters of interest include low Mach number starting capability, start sensitivity as a function of back pressure at various contraction ratios, flow turning angles, strut and throat bleed effects, and pressure recovery at various Mach numbers.

  7. Design of JT-60SA magnets and associated experimental validations

    International Nuclear Information System (INIS)

    Zani, L.; Barabaschi, P.; Peyrot, M.; Meunier, L.; Tomarchio, V.; Duglue, D.; Decool, P.; Torre, A.; Marechal, J.L.; Della Corte, A.; Di Zenobio, A.; Muzzi, L.; Cucchiaro, A.; Turtu, S.; Ishida, S.; Yoshida, K.; Tsuchiya, K.; Kizu, K.; Murakami, H.

    2011-01-01

    In the framework of the JT-60SA project, aiming at upgrading the present JT-60U tokamak toward a fully superconducting configuration, the detailed design phase led to adopt for the three main magnet systems a brand new design. Europe (EU) is expected to provide to Japan (JA) the totality of the toroidal field (TF) magnet system, while JA will provide both Equilibrium field (EF) and Central Solenoid (CS) systems. All magnet designs were optimized trough the past years and entered in parallel into extensive experimentally-based phases of concept validation, which came to maturation in the years 2009 and 2010. For this, all magnet systems were investigated by mean of dedicated samples, e.g. conductor and joint samples designed, manufactured and tested at full scale in ad hoc facilities either in EU or in JA. The present paper, after an overall description of magnet systems layouts, presents in a general approach the different experimental campaigns dedicated to qualification design and manufacture processes of either coils, conductors and electrical joints. The main results with the associated analyses are shown and the main conclusions presented, especially regarding their contribution to consolidate the triggering of magnet mass production. The status of respective manufacturing stages in EU and in JA are also evoked. (authors)

  8. Design-validation of a hand exoskeleton using musculoskeletal modeling.

    Science.gov (United States)

    Hansen, Clint; Gosselin, Florian; Ben Mansour, Khalil; Devos, Pierre; Marin, Frederic

    2018-04-01

    Exoskeletons are progressively reaching homes and workplaces, allowing interaction with virtual environments, remote control of robots, or assisting human operators in carrying heavy loads. Their design is however still a challenge as these robots, being mechanically linked to the operators who wear them, have to meet ergonomic constraints besides usual robotic requirements in terms of workspace, speed, or efforts. They have in particular to fit the anthropometry and mobility of their users. This traditionally results in numerous prototypes which are progressively fitted to each individual person. In this paper, we propose instead to validate the design of a hand exoskeleton in a fully digital environment, without the need for a physical prototype. The purpose of this study is thus to examine whether finger kinematics are altered when using a given hand exoskeleton. Therefore, user specific musculoskeletal models were created and driven by a motion capture system to evaluate the fingers' joint kinematics when performing two industrial related tasks. The kinematic chain of the exoskeleton was added to the musculoskeletal models and its compliance with the hand movements was evaluated. Our results show that the proposed exoskeleton design does not influence fingers' joints angles, the coefficient of determination between the model with and without exoskeleton being consistently high (R 2 ¯=0.93) and the nRMSE consistently low (nRMSE¯ = 5.42°). These results are promising and this approach combining musculoskeletal and robotic modeling driven by motion capture data could be a key factor in the ergonomics validation of the design of orthotic devices and exoskeletons prior to manufacturing. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Experimental validation of a new heterogeneous mechanical test design

    Science.gov (United States)

    Aquino, J.; Campos, A. Andrade; Souto, N.; Thuillier, S.

    2018-05-01

    Standard material parameters identification strategies generally use an extensive number of classical tests for collecting the required experimental data. However, a great effort has been made recently by the scientific and industrial communities to support this experimental database on heterogeneous tests. These tests can provide richer information on the material behavior allowing the identification of a more complete set of material parameters. This is a result of the recent development of full-field measurements techniques, like digital image correlation (DIC), that can capture the heterogeneous deformation fields on the specimen surface during the test. Recently, new specimen geometries were designed to enhance the richness of the strain field and capture supplementary strain states. The butterfly specimen is an example of these new geometries, designed through a numerical optimization procedure where an indicator capable of evaluating the heterogeneity and the richness of strain information. However, no experimental validation was yet performed. The aim of this work is to experimentally validate the heterogeneous butterfly mechanical test in the parameter identification framework. For this aim, DIC technique and a Finite Element Model Up-date inverse strategy are used together for the parameter identification of a DC04 steel, as well as the calculation of the indicator. The experimental tests are carried out in a universal testing machine with the ARAMIS measuring system to provide the strain states on the specimen surface. The identification strategy is accomplished with the data obtained from the experimental tests and the results are compared to a reference numerical solution.

  10. Artificial intelligence applications to design validation and sneak function analysis

    International Nuclear Information System (INIS)

    Stratton, R.C.

    1985-01-01

    An objective of the US space reactor program is to design systems with high reliability and safety of control over long operating lifetimes. Argonne National Laboratory (ANL) is a participant in the National Man-Machine Integration (MMI) program for Liquid Metal Fast Breeder Reactors (LMFBR). A purpose of this program is to promote the development of concepts and technologies that enhance the operational safety and reliability of fast-breeder reactors. Much of the work is directly applicable to the space reactor program. This paper reports on one of the MMI projects being developed by ANL. The project reported pertains to an automated system that demonstrates the use of artificial intelligence (AI) for design validation (DA) and sneak function analysis (SFA). The AI system models the design specification and the physical design of the cooling process assigned to the Argon Cooling System (ACS) at Experimental Breeder Reactor II (EBR-II). The models are developed using heuristic knowledge and natural laws. 13 refs

  11. Design validation and performance of closed loop gas recirculation system

    International Nuclear Information System (INIS)

    Kalmani, S.D.; Majumder, G.; Mondal, N.K.; Shinde, R.R.; Joshi, A.V.

    2016-01-01

    A pilot experimental set up of the India Based Neutrino Observatory's ICAL detector has been operational for the last 4 years at TIFR, Mumbai. Twelve glass RPC detectors of size 2 × 2 m 2 , with a gas gap of 2 mm are under test in a closed loop gas recirculation system. These RPCs are continuously purged individually, with a gas mixture of R134a (C 2 H 2 F 4 ), isobutane (iC 4 H 10 ) and sulphur hexafluoride (SF 6 ) at a steady rate of 360 ml/h to maintain about one volume change a day. To economize gas mixture consumption and to reduce the effluents from being released into the atmosphere, a closed loop system has been designed, fabricated and installed at TIFR. The pressure and flow rate in the loop is controlled by mass flow controllers and pressure transmitters. The performance and integrity of RPCs in the pilot experimental set up is being monitored to assess the effect of periodic fluctuation and transients in atmospheric pressure and temperature, room pressure variation, flow pulsations, uniformity of gas distribution and power failures. The capability of closed loop gas recirculation system to respond to these changes is also studied. The conclusions from the above experiment are presented. The validations of the first design considerations and subsequent modifications have provided improved guidelines for the future design of the engineering module gas system.

  12. Design and Control of Compliant Tensegrity Robots Through Simulation and Hardware Validation

    Science.gov (United States)

    Caluwaerts, Ken; Despraz, Jeremie; Iscen, Atil; Sabelhaus, Andrew P.; Bruce, Jonathan; Schrauwen, Benjamin; Sunspiral, Vytas

    2014-01-01

    To better understand the role of tensegrity structures in biological systems and their application to robotics, the Dynamic Tensegrity Robotics Lab at NASA Ames Research Center has developed and validated two different software environments for the analysis, simulation, and design of tensegrity robots. These tools, along with new control methodologies and the modular hardware components developed to validate them, are presented as a system for the design of actuated tensegrity structures. As evidenced from their appearance in many biological systems, tensegrity ("tensile-integrity") structures have unique physical properties which make them ideal for interaction with uncertain environments. Yet these characteristics, such as variable structural compliance, and global multi-path load distribution through the tension network, make design and control of bio-inspired tensegrity robots extremely challenging. This work presents the progress in using these two tools in tackling the design and control challenges. The results of this analysis includes multiple novel control approaches for mobility and terrain interaction of spherical tensegrity structures. The current hardware prototype of a six-bar tensegrity, code-named ReCTeR, is presented in the context of this validation.

  13. DESIGN AND VALIDATION OF AN INTERORGANIZATIONAL INFORMATION SYSTEM

    Directory of Open Access Journals (Sweden)

    Kamel Rouibah

    2006-01-01

    Full Text Available This paper presents an interorganizational information system that aims to structure collaboration of engineering activities as well as data sharing across company borders. The paper also describes the approach underlying the system, validates it by designing a system prototype, and tests the system using questionnaire and in-depth interviews in order to further knowledge about the subject. The main results from the test show: collaboration engineering is potentially important for senior managers; end-users were specifically attracted more by the concept rather by its implementation; engineering change management is a complex process; and the support of strategic level is a critical success factor. In addition, the paper describes other factors that emerged during the ongoing project and inhibit success of the system.

  14. [Design and validation of an oral health questionnaire for preoperative anaesthetic evaluation].

    Science.gov (United States)

    Ruíz-López Del Prado, Gema; Blaya-Nováková, Vendula; Saz-Parkinson, Zuleika; Álvarez-Montero, Óscar Luis; Ayala, Alba; Muñoz-Moreno, Maria Fe; Forjaz, Maria João

    Dental injuries incurred during endotracheal intubation are more frequent in patients with previous oral pathology. The study objectives were to develop an oral health questionnaire for preanaesthesia evaluation, easy to apply for personnel without special dental training; and establish a cut-off value for detecting persons with poor oral health. Validation study of a self-administered questionnaire, designed according to a literature review and an expert group's recommendations. The questionnaire was applied to a sample of patients evaluated in a preanaesthesia consultation. Rasch analysis of the questionnaire psychometric properties included viability, acceptability, content validity and reliability of the scale. The sample included 115 individuals, 50.4% of men, with a median age of 58 years (range: 38-71). The final analysis of 11 items presented a Person Separation Index of 0.861 and good adjustment of data to the Rasch model. The scale was unidimensional and its items were not biased by sex, age or nationality. The oral health linear measure presented good construct validity. The cut-off value was set at 52 points. The questionnaire showed sufficient psychometric properties to be considered a reliable tool, valid for measuring the state of oral health in preoperative anaesthetic evaluations. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

  15. Design and validation of an oral health questionnaire for preoperative anaesthetic evaluation

    Directory of Open Access Journals (Sweden)

    Gema Ruíz-López del Prado

    Full Text Available Abstract Background and objectives: Dental injuries incurred during endotracheal intubation are more frequent in patients with previous oral pathology. The study objectives were to develop an oral health questionnaire for preanaesthesia evaluation, easy to apply for personnel without special dental training; and establish a cut-off value for detecting persons with poor oral health. Methods: Validation study of a self-administered questionnaire, designed according to a literature review and an expert group's recommendations. The questionnaire was applied to a sample of patients evaluated in a preanaesthesia consultation. Rasch analysis of the questionnaire psychometric properties included viability, acceptability, content validity and reliability of the scale. Results: The sample included 115 individuals, 50.4% of men, with a median age of 58 years (range: 38-71. The final analysis of 11 items presented a Person Separation Index of 0.861 and good adjustment of data to the Rasch model. The scale was unidimensional and its items were not biased by sex, age or nationality. The oral health linear measure presented good construct validity. The cut-off value was set at 52 points. Conclusions: The questionnaire showed sufficient psychometric properties to be considered a reliable tool, valid for measuring the state of oral health in preoperative anaesthetic evaluations.

  16. Design and validation of an oral health questionnaire for preoperative anaesthetic evaluation.

    Science.gov (United States)

    Ruíz-López Del Prado, Gema; Blaya-Nováková, Vendula; Saz-Parkinson, Zuleika; Álvarez-Montero, Óscar Luis; Ayala, Alba; Muñoz-Moreno, Maria Fe; Forjaz, Maria João

    Dental injuries incurred during endotracheal intubation are more frequent in patients with previous oral pathology. The study objectives were to develop an oral health questionnaire for preanaesthesia evaluation, easy to apply for personnel without special dental training; and establish a cut-off value for detecting persons with poor oral health. Validation study of a self-administered questionnaire, designed according to a literature review and an expert group's recommendations. The questionnaire was applied to a sample of patients evaluated in a preanaesthesia consultation. Rasch analysis of the questionnaire psychometric properties included viability, acceptability, content validity and reliability of the scale. The sample included 115 individuals, 50.4% of men, with a median age of 58 years (range: 38-71). The final analysis of 11 items presented a Person Separation Index of 0.861 and good adjustment of data to the Rasch model. The scale was unidimensional and its items were not biased by sex, age or nationality. The oral health linear measure presented good construct validity. The cut-off value was set at 52 points. The questionnaire showed sufficient psychometric properties to be considered a reliable tool, valid for measuring the state of oral health in preoperative anaesthetic evaluations. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

  17. Developmental framework to validate future designs of ballistic neck protection.

    Science.gov (United States)

    Breeze, J; Midwinter, M J; Pope, D; Porter, K; Hepper, A E; Clasper, J

    2013-01-01

    The number of neck injuries has increased during the war in Afghanistan, and they have become an appreciable source of mortality and long-term morbidity for UK servicemen. A three-dimensional numerical model of the neck is necessary to allow simulation of penetrating injury from explosive fragments so that the design of body armour can be optimal, and a framework is required to validate and describe the individual components of this program. An interdisciplinary consensus group consisting of military maxillofacial surgeons, and biomedical, physical, and material scientists was convened to generate the components of the framework, and as a result it incorporates the following components: analysis of deaths and long-term morbidity, assessment of critical cervical structures for incorporation into the model, characterisation of explosive fragments, evaluation of the material of which the body armour is made, and mapping of the entry sites of fragments. The resulting numerical model will simulate the wound tract produced by fragments of differing masses and velocities, and illustrate the effects of temporary cavities on cervical neurovascular structures. Using this framework, a new shirt to be worn under body armour that incorporates ballistic cervical protection has been developed for use in Afghanistan. New designs of the collar validated by human factors and assessment of coverage are currently being incorporated into early versions of the numerical model. The aim of this paper is to describe this developmental framework and provide an update on the current progress of its individual components. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

  18. The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties

    Science.gov (United States)

    Bennett, Robert M; Friend, Ronald; Jones, Kim D; Ward, Rachel; Han, Bobby K; Ross, Rebecca L

    2009-01-01

    Introduction The Fibromyalgia Impact Questionnaire (FIQ) is a commonly used instrument in the evaluation of fibromyalgia (FM) patients. Over the last 18 years, since the publication of the original FIQ, several deficiencies have become apparent and the cumbersome scoring algorithm has been a barrier to widespread clinical use. The aim of this paper is to describe and validate a revised version of the FIQ: the FIQR. Methods The FIQR was developed in response to known deficiencies of the FIQ with the help of a patient focus group. The FIQR has the same 3 domains as the FIQ (that is, function, overall impact and symptoms). It differs from the FIQ in having modified function questions and the inclusion of questions on memory, tenderness, balance and environmental sensitivity. All questions are graded on a 0–10 numeric scale. The FIQR was administered online and the results were compared to the same patient's online responses to the 36-Item Short Form Health Survey (SF-36) and the original FIQ. Results The FIQR was completed online by 202 FM patients, 51 rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) patients (31 RA and 20 SLE), 11 patients with major depressive disorder (MDD) and 213 healthy controls (HC). The mean total FIQR score was 56.6 ± 19.9 compared to a total FIQ score of 60.6 ± 17.8 (P FIQ were closely correlated (r = 0.88, P FIQ domains (r = 0.69 to 0.88, P FIQ that has good psychometric properties, can be completed in less than 2 minutes and is easy to score. It has scoring characteristics comparable to the original FIQ, making it possible to compare past FIQ results with future FIQR results. PMID:19664287

  19. Design and validation of the Quantum Mechanics Conceptual Survey

    Directory of Open Access Journals (Sweden)

    S. B. McKagan

    2010-11-01

    Full Text Available The Quantum Mechanics Conceptual Survey (QMCS is a 12-question survey of students’ conceptual understanding of quantum mechanics. It is intended to be used to measure the relative effectiveness of different instructional methods in modern physics courses. In this paper, we describe the design and validation of the survey, a process that included observations of students, a review of previous literature and textbooks and syllabi, faculty and student interviews, and statistical analysis. We also discuss issues in the development of specific questions, which may be useful both for instructors who wish to use the QMCS in their classes and for researchers who wish to conduct further research of student understanding of quantum mechanics. The QMCS has been most thoroughly tested in, and is most appropriate for assessment of (as a posttest only, sophomore-level modern physics courses. We also describe testing with students in junior quantum courses and graduate quantum courses, from which we conclude that the QMCS may be appropriate for assessing junior quantum courses, but is not appropriate for assessing graduate courses. One surprising result of our faculty interviews is a lack of faculty consensus on what topics should be taught in modern physics, which has made designing a test that is valued by a majority of physics faculty more difficult than expected.

  20. Flight critical system design guidelines and validation methods

    Science.gov (United States)

    Holt, H. M.; Lupton, A. O.; Holden, D. G.

    1984-01-01

    Efforts being expended at NASA-Langley to define a validation methodology, techniques for comparing advanced systems concepts, and design guidelines for characterizing fault tolerant digital avionics are described with an emphasis on the capabilities of AIRLAB, an environmentally controlled laboratory. AIRLAB has VAX 11/750 and 11/780 computers with an aggregate of 22 Mb memory and over 650 Mb storage, interconnected at 256 kbaud. An additional computer is programmed to emulate digital devices. Ongoing work is easily accessed at user stations by either chronological or key word indexing. The CARE III program aids in analyzing the capabilities of test systems to recover from faults. An additional code, the semi-Markov unreliability program (SURE) generates upper and lower reliability bounds. The AIRLAB facility is mainly dedicated to research on designs of digital flight-critical systems which must have acceptable reliability before incorporation into aircraft control systems. The digital systems would be too costly to submit to a full battery of flight tests and must be initially examined with the AIRLAB simulation capabilities.

  1. Design, construction and validation of the UST-1 modular stellarator

    Energy Technology Data Exchange (ETDEWEB)

    Queral, V., E-mail: vicentemanuel.queral@ciemat.es

    2016-11-15

    Highlights: • A small and simple low cost two period modular stellarator is reviewed. • It is defined as a monolithic circular surface torus with carved grooves. • The grooves are accurately mechanised by a new toroidal milling machine. • A very simple e-beam field mapping system has been built and utilized. - Abstract: Stellarator advancement is hindered, among others, by the requirement of geometric complexity at high accuracy and the still scarce universities and research centres following the stellarator line. In this framework, the objectives of the small UST-1 stellarator development were to: (i) explore and test the performance of one possible accurate construction method for stellarators (ii) encourage universities and small fusion research centres to build simple and economical stellarators (iii) educative purpose. Therefore, UST-1 was properly designed to be easily built by a milling machine working on toroidal coordinates, being the winding surface circular poloidally and toroidally. The coil frame is a sole monolithic toroidal thick surface equipped with grooves mechanised by the toroidal milling machine. Only one double pancake is wound in each groove so as to compress the conductor on the laterals of the groove in order to speed up and simplify the winding process. The physics design, the conceptual engineering design and the construction process of UST-1 is presented. The toroidal milling machine is described. The e-beam field line mapping experiments carried out to validate the resulting magnetic configuration are reported. The developed construction method has been proved for the small UST-1 stellarator. Small stellarators are valuable for quick tests of diagnostics, educative purposes, assessment of new confinement concepts, turbulence studies and other applications.

  2. Design, construction and validation of the UST-1 modular stellarator

    International Nuclear Information System (INIS)

    Queral, V.

    2016-01-01

    Highlights: • A small and simple low cost two period modular stellarator is reviewed. • It is defined as a monolithic circular surface torus with carved grooves. • The grooves are accurately mechanised by a new toroidal milling machine. • A very simple e-beam field mapping system has been built and utilized. - Abstract: Stellarator advancement is hindered, among others, by the requirement of geometric complexity at high accuracy and the still scarce universities and research centres following the stellarator line. In this framework, the objectives of the small UST-1 stellarator development were to: (i) explore and test the performance of one possible accurate construction method for stellarators (ii) encourage universities and small fusion research centres to build simple and economical stellarators (iii) educative purpose. Therefore, UST-1 was properly designed to be easily built by a milling machine working on toroidal coordinates, being the winding surface circular poloidally and toroidally. The coil frame is a sole monolithic toroidal thick surface equipped with grooves mechanised by the toroidal milling machine. Only one double pancake is wound in each groove so as to compress the conductor on the laterals of the groove in order to speed up and simplify the winding process. The physics design, the conceptual engineering design and the construction process of UST-1 is presented. The toroidal milling machine is described. The e-beam field line mapping experiments carried out to validate the resulting magnetic configuration are reported. The developed construction method has been proved for the small UST-1 stellarator. Small stellarators are valuable for quick tests of diagnostics, educative purposes, assessment of new confinement concepts, turbulence studies and other applications.

  3. High Level Analysis, Design and Validation of Distributed Mobile Systems with CoreASM

    Science.gov (United States)

    Farahbod, R.; Glässer, U.; Jackson, P. J.; Vajihollahi, M.

    System design is a creative activity calling for abstract models that facilitate reasoning about the key system attributes (desired requirements and resulting properties) so as to ensure these attributes are properly established prior to actually building a system. We explore here the practical side of using the abstract state machine (ASM) formalism in combination with the CoreASM open source tool environment for high-level design and experimental validation of complex distributed systems. Emphasizing the early phases of the design process, a guiding principle is to support freedom of experimentation by minimizing the need for encoding. CoreASM has been developed and tested building on a broad scope of applications, spanning computational criminology, maritime surveillance and situation analysis. We critically reexamine here the CoreASM project in light of three different application scenarios.

  4. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  5. Validation of a buffet meal design in an experimental restaurant.

    Science.gov (United States)

    Allirot, Xavier; Saulais, Laure; Disse, Emmanuel; Roth, Hubert; Cazal, Camille; Laville, Martine

    2012-06-01

    We assessed the reproducibility of intakes and meal mechanics parameters (cumulative energy intake (CEI), number of bites, bite rate, mean energy content per bite) during a buffet meal designed in a natural setting, and their sensitivity to food deprivation. Fourteen men were invited to three lunch sessions in an experimental restaurant. Subjects ate their regular breakfast before sessions A and B. They skipped breakfast before session FAST. The same ad libitum buffet was offered each time. Energy intakes and meal mechanics were assessed by foods weighing and video recording. Intrasubject reproducibility was evaluated by determining intraclass correlation coefficients (ICC). Mixed-models were used to assess the effects of the sessions on CEI. We found a good reproducibility between A and B for total energy (ICC=0.82), carbohydrate (ICC=0.83), lipid (ICC=0.81) and protein intake (ICC=0.79) and for meal mechanics parameters. Total energy, lipid and carbohydrate intake were higher in FAST than in A and B. CEI were found sensitive to differences in hunger level while the other meal mechanics parameters were stable between sessions. In conclusion, a buffet meal in a normal eating environment is a valid tool for assessing the effects of interventions on intakes. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Validation of a laboratory method for evaluating dynamic properties of reconstructed equine racetrack surfaces.

    Directory of Open Access Journals (Sweden)

    Jacob J Setterbo

    Full Text Available Racetrack surface is a risk factor for racehorse injuries and fatalities. Current research indicates that race surface mechanical properties may be influenced by material composition, moisture content, temperature, and maintenance. Race surface mechanical testing in a controlled laboratory setting would allow for objective evaluation of dynamic properties of surface and factors that affect surface behavior.To develop a method for reconstruction of race surfaces in the laboratory and validate the method by comparison with racetrack measurements of dynamic surface properties.Track-testing device (TTD impact tests were conducted to simulate equine hoof impact on dirt and synthetic race surfaces; tests were performed both in situ (racetrack and using laboratory reconstructions of harvested surface materials. Clegg Hammer in situ measurements were used to guide surface reconstruction in the laboratory. Dynamic surface properties were compared between in situ and laboratory settings. Relationships between racetrack TTD and Clegg Hammer measurements were analyzed using stepwise multiple linear regression.Most dynamic surface property setting differences (racetrack-laboratory were small relative to surface material type differences (dirt-synthetic. Clegg Hammer measurements were more strongly correlated with TTD measurements on the synthetic surface than the dirt surface. On the dirt surface, Clegg Hammer decelerations were negatively correlated with TTD forces.Laboratory reconstruction of racetrack surfaces guided by Clegg Hammer measurements yielded TTD impact measurements similar to in situ values. The negative correlation between TTD and Clegg Hammer measurements confirms the importance of instrument mass when drawing conclusions from testing results. Lighter impact devices may be less appropriate for assessing dynamic surface properties compared to testing equipment designed to simulate hoof impact (TTD.Dynamic impact properties of race surfaces

  7. Development and Validation of a Rubric for Diagnosing Students’ Experimental Design Knowledge and Difficulties

    Science.gov (United States)

    Dasgupta, Annwesa P.; Anderson, Trevor R.

    2014-01-01

    It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students’ responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students’ experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. PMID:26086658

  8. Design and validation of portable optical instrument for crop diagnose

    Science.gov (United States)

    Sun, Gang; Zheng, Wengang; Huang, Wengjiang; Wan, Huawei; Liu, Liangyun

    2005-12-01

    In this paper, a portable diagnostic instrument was designed and tested, which can measure the normalized difference vegetation index (NDVI) and structure insensitive pigment index (SIPI) of crop canopy in field. The instrument have a valid survey area of 1 m*1 m when the height between instrument and the ground was fixed to 1.3 meter The crop growth condition can be assessed based on their NDVI and SIPI values, so it will be very important for crop management to get these values. The instrument uses sunlight as its light source. There are six special different photoelectrical detectors within red, blue and near infrared bands, which are used for detecting incidence sunlight and reflex light from the canopy of crop. This optical instrument includes photoelectric detector module, signal process and A/D convert module, the data storing and transmission module and human-machine interface module. The detector is the core of the instrument which measures the spectrums at special bands. The microprocessor calculates the NDVI and SIPI value based on the A/D value. And the value can be displayed on the instrument's LCD, stored in the flash memory of instrument and can also be uploaded to PC through the PC's RS232 serial interface. The prototype was tested in the crop field at different view directions. This paper also provided the method of calibration, the results showed that the average measurement error to SIPI value of instrument was 5.25% and the average measurement error to NDVI value in vegetation-covered region is 6.40%. It reveals the on-site and non-sampling mode of crop growth monitoring by fixed on the agricultural machine traveling in the field.

  9. Lumber stress grades and design properties

    Science.gov (United States)

    David E. Kretschmann; David W. Green

    1999-01-01

    Lumber sawn from a log, regardless of species and size, is quite variable in mechanical properties. Pieces may differ in strength by several hundred percent. For simplicity and economy in use, pieces of lumber of similar mechanical properties are placed in categories called stress grades, which are characterized by (a) one or more sorting criteria, (b) a set of...

  10. Design and Experimental Validation of a USBL Underwater Acoustic Positioning System.

    Science.gov (United States)

    Reis, Joel; Morgado, Marco; Batista, Pedro; Oliveira, Paulo; Silvestre, Carlos

    2016-09-14

    This paper presents the steps for developing a low-cost POrtableNavigation Tool for Underwater Scenarios (PONTUS) to be used as a localization device for subsea targets. PONTUS consists of an integrated ultra-short baseline acoustic positioning system aided by an inertial navigation system. Built on a practical design, it can be mounted on an underwater robotic vehicle or be operated by a scuba diver. It also features a graphical user interface that provides information on the tracking of the designated target, in addition to some details on the physical properties inside PONTUS. A full disclosure of the architecture of the tool is first presented, followed by thorough technical descriptions of the hardware components ensemble and the software development process. A series of experiments was carried out to validate the developed prototype, and the results are presented herein, which allow assessing its overall performance.

  11. Design and Experimental Validation of a USBL Underwater Acoustic Positioning System

    Directory of Open Access Journals (Sweden)

    Joel Reis

    2016-09-01

    Full Text Available This paper presents the steps for developing a low-cost POrtableNavigation Tool for Underwater Scenarios (PONTUS to be used as a localization device for subsea targets. PONTUS consists of an integrated ultra-short baseline acoustic positioning system aided by an inertial navigation system. Built on a practical design, it can be mounted on an underwater robotic vehicle or be operated by a scuba diver. It also features a graphical user interface that provides information on the tracking of the designated target, in addition to some details on the physical properties inside PONTUS. A full disclosure of the architecture of the tool is first presented, followed by thorough technical descriptions of the hardware components ensemble and the software development process. A series of experiments was carried out to validate the developed prototype, and the results are presented herein, which allow assessing its overall performance.

  12. Design and validation of a questionnaire to assess organizational culture in French hospital wards.

    Science.gov (United States)

    Saillour-Glénisson, F; Domecq, S; Kret, M; Sibe, M; Dumond, J P; Michel, P

    2016-09-17

    Although many organizational culture questionnaires have been developed, there is a lack of any validated multidimensional questionnaire assessing organizational culture at hospital ward level and adapted to health care context. Facing the lack of an appropriate tool, a multidisciplinary team designed and validated a dimensional organizational culture questionnaire for healthcare settings to be administered at ward level. A database of organizational culture items and themes was created after extensive literature review. Items were regrouped into dimensions and subdimensions (classification validated by experts). Pre-test and face validation was conducted with 15 health care professionals. In a stratified cluster random sample of hospitals, the psychometric validation was conducted in three phases on a sample of 859 healthcare professionals from 36 multidisciplinary medicine services: 1) the exploratory phase included a description of responses' saturation levels, factor and correlations analyses and an internal consistency analysis (Cronbach's alpha coefficient); 2) confirmatory phase used the Structural Equation Modeling (SEM); 3) reproducibility was studied by a test-retest. The overall response rate was 80 %; the completion average was 97 %. The metrological results were: a global Cronbach's alpha coefficient of 0.93, higher than 0.70 for 12 sub-dimensions; all Dillon-Goldstein's rho coefficients higher than 0.70; an excellent quality of external model with a Goodness of Fitness (GoF) criterion of 0.99. Seventy percent of the items had a reproducibility ranging from moderate (Intra-Class Coefficient between 50 and 70 % for 25 items) to good (ICC higher than 70 % for 33 items). COMEt (Contexte Organisationnel et Managérial en Etablissement de Santé) questionnaire is a validated multidimensional organizational culture questionnaire made of 6 dimensions, 21 sub-dimensions and 83 items. It is the first dimensional organizational culture questionnaire

  13. Integrated Design Validation: Combining Simulation and Formal Verification for Digital Integrated Circuits

    Directory of Open Access Journals (Sweden)

    Lun Li

    2006-04-01

    Full Text Available The correct design of complex hardware continues to challenge engineers. Bugs in a design that are not uncovered in early design stages can be extremely expensive. Simulation is a predominantly used tool to validate a design in industry. Formal verification overcomes the weakness of exhaustive simulation by applying mathematical methodologies to validate a design. The work described here focuses upon a technique that integrates the best characteristics of both simulation and formal verification methods to provide an effective design validation tool, referred as Integrated Design Validation (IDV. The novelty in this approach consists of three components, circuit complexity analysis, partitioning based on design hierarchy, and coverage analysis. The circuit complexity analyzer and partitioning decompose a large design into sub-components and feed sub-components to different verification and/or simulation tools based upon known existing strengths of modern verification and simulation tools. The coverage analysis unit computes the coverage of design validation and improves the coverage by further partitioning. Various simulation and verification tools comprising IDV are evaluated and an example is used to illustrate the overall validation process. The overall process successfully validates the example to a high coverage rate within a short time. The experimental result shows that our approach is a very promising design validation method.

  14. The Revised Fibromyalgia Impact Questionnaire (FIQR): validation and psychometric properties

    OpenAIRE

    Bennett, Robert M; Friend, Ronald; Jones, Kim D; Ward, Rachel; Han, Bobby K; Ross, Rebecca L

    2009-01-01

    Introduction The Fibromyalgia Impact Questionnaire (FIQ) is a commonly used instrument in the evaluation of fibromyalgia (FM) patients. Over the last 18 years, since the publication of the original FIQ, several deficiencies have become apparent and the cumbersome scoring algorithm has been a barrier to widespread clinical use. The aim of this paper is to describe and validate a revised version of the FIQ: the FIQR. Methods The FIQR was developed in response to known deficiencies of the FIQ wi...

  15. Property Modelling and Databases in Product-Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Sansonetti, Sascha

    of the PC-SAFT is used. The developed database and property prediction models have been combined into a properties-software that allows different product-process design related applications. The presentation will also briefly highlight applications of the software for virtual product-process design...

  16. Structural and functional properties of designed globins

    Indian Academy of Sciences (India)

    De novo design of artificial proteins is an essential approach to elucidate the principles of protein architecture and to understand specific functions of natural proteins and also to yield novel molecules for medical and industrial aims. We have designed artificial sequences of 153 amino acids to fit the main-chain framework of ...

  17. Design of an intermediate-scale experiment to validate unsaturated- zone transport models

    International Nuclear Information System (INIS)

    Siegel, M.D.; Hopkins, P.L.; Glass, R.J.; Ward, D.B.

    1991-01-01

    An intermediate-scale experiment is being carried out to evaluate instrumentation and models that might be used for transport-model validation for the Yucca Mountain Site Characterization Project. The experimental test bed is a 6-m high x 3-m diameter caisson filled with quartz sand with a sorbing layer at an intermediate depth. The experiment involves the detection and prediction of the migration of fluid and tracers through an unsaturated porous medium. Pre-test design requires estimation of physical properties of the porous medium such as the relative permeability, saturation/pressure relations, porosity, and saturated hydraulic conductivity as well as geochemical properties such as surface complexation constants and empircial K d 'S. The pre-test characterization data will be used as input to several computer codes to predict the fluid flow and tracer migration. These include a coupled chemical-reaction/transport model, a stochastic model, and a deterministic model using retardation factors. The calculations will be completed prior to elution of the tracers, providing a basis for validation by comparing the predictions to observed moisture and tracer behavior

  18. Property Modelling for Applications in Chemical Product and Process Design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    such as database, property model library, model parameter regression, and, property-model based product-process design will be presented. The database contains pure component and mixture data for a wide range of organic chemicals. The property models are based on the combined group contribution and atom...... is missing, the atom connectivity based model is employed to predict the missing group interaction. In this way, a wide application range of the property modeling tool is ensured. Based on the property models, targeted computer-aided techniques have been developed for design and analysis of organic chemicals......, polymers, mixtures as well as separation processes. The presentation will highlight the framework (ICAS software) for property modeling, the property models and issues such as prediction accuracy, flexibility, maintenance and updating of the database. Also, application issues related to the use of property...

  19. A design of a valid signal selecting and position decoding ASIC for PET using silicon photomultipliers

    International Nuclear Information System (INIS)

    Cho, M.; Lim, K.-T.; Kim, J.; Lee, C.; Cho, G.; Kim, H.; Yeom, J.-Y.; Choi, H.

    2017-01-01

    In most cases, a PET system has numerous electrical components and channel circuits and thus it would rather be a bulky product. Also, most existing systems receive analog signals from detectors which make them vulnerable to signal distortions. For these reasons, channel reduction techniques are important. In this work, an ASIC for PET module is being proposed. An ASIC chip for 16 PET detector channels, VSSPDC, has been designed and simulated. The main function of the chip is 16-to-1 channel reduction, i.e., finding the position of only the valid signals, signal timing, and magnitudes in all 16 channels at every recorded event. The ASIC comprises four of 4-channel modules and a 2 nd 4-to-1 router. A single channel module comprises a transimpedance amplifier for the silicon photomultipliers, dual comparators with high and low level references, and a logic circuitry. While the high level reference was used to test the validity of the signal, the low level reference was used for the timing. The 1-channel module of the ASIC produced an energy pulse by time-over-threshold method and it also produced a time pulse with a fixed delayed time. Since the ASIC chip outputs only a few digital pulses and does not require an external clock, it has an advantage over noise properties. The cadence simulation showed the good performance of the chip as designed.

  20. Design and validation of a questionnaire for measuring perceived risk of skin cancer.

    Science.gov (United States)

    Morales-Sánchez, M A; Peralta-Pedrero, M L; Domínguez-Gómez, M A

    2014-04-01

    A perceived risk of cancer encourages preventive behavior while the lack of such a perception is a barrier to risk reduction. There are no instruments in Spanish to measure this perceived risk and thus quantify response to interventions for preventing this disease at a population level. The aim of this study was to design and validate a self-administered questionnaire for measuring the perceived risk of skin cancer. A self-administered questionnaire with a visual Likert-type scale was designed based on the results of the analysis of the content of a survey performed in 100 patients in the Dr. Ladislao de la Pascua Skin Clinic, Distrito Federal México, Mexico. Subsequently, the questionnaire was administered to a sample of 359 adult patients who attended the clinic for the first time. As no gold standard exists for measuring the perceived risk of skin cancer, the construct was validated through factor analysis. The final questionnaire had 18 items. The internal consistency measured with Cronbach α was 0.824 overall. In the factor analysis, 4 factors (denoted as affective, behavioral, severity, and susceptibility) and an indicator of risk accounted for 65.133% of the variance. The psychometric properties of the scale were appropriate for measuring the perception of risk in adult patients (aged 18 years or more) who attended the dermatology clinic. Copyright © 2013 Elsevier España, S.L. and AEDV. All rights reserved.

  1. Computational chemical product design problems under property uncertainties

    DEFF Research Database (Denmark)

    Frutiger, Jerome; Cignitti, Stefano; Abildskov, Jens

    2017-01-01

    Three different strategies of how to combine computational chemical product design with Monte Carlo based methods for uncertainty analysis of chemical properties are outlined. One method consists of a computer-aided molecular design (CAMD) solution and a post-processing property uncertainty...... fluid design. While the higher end of the uncertainty range of the process model output is similar for the best performing fluids, the lower end of the uncertainty range differs largely....

  2. Sensitivity of Process Design due to Uncertainties in Property Estimates

    DEFF Research Database (Denmark)

    Hukkerikar, Amol; Jones, Mark Nicholas; Sarup, Bent

    2012-01-01

    The objective of this paper is to present a systematic methodology for performing analysis of sensitivity of process design due to uncertainties in property estimates. The methodology provides the following results: a) list of properties with critical importance on design; b) acceptable levels of...... in chemical processes. Among others vapour pressure accuracy for azeotropic mixtures is critical and needs to be measured or estimated with a ±0.25% accuracy to satisfy acceptable safety levels in design....

  3. Physics validation for design change of KSTAR passive stabilizer

    Science.gov (United States)

    Jeon, Y. M.; Kim, J. Y.; Oh, Y. K.; Yang, H. L.; Kim, W. C.; Kim, H. K.; Sabbagh, S. A.; Bialek, J. M.; Humphreys, D. A.; Welander, A. S.; Walker, M. L.

    2009-11-01

    Recently, the design of the passive stabilizer in KSTAR has been changed to improve controllability of the active control system and reduce the possibility of producing an additional error field. Originally the passive stabilizer in KSTAR was designed for RWM and vertical instability (or VDE) stabilizations and plasma startup efficiency, so that current bridges were designed and combined through 3D saddle-loop connections. Since the key design change is removing the current bridges, it's essential to assure satisfactory control performance for these instabilities under the design change. Control capability for n=1 RWM and achievable βN will be addressed as a primary goal of the passive stabilizer together with vertical instability control and effects on plasma startup. In addition, the changes in electro-magnetic force on conducting structures will be discussed qualitatively as a key engineering issue of the design change.

  4. Design and mechanical properties of insect cuticle.

    Science.gov (United States)

    Vincent, Julian F V; Wegst, Ulrike G K

    2004-07-01

    Since nearly all adult insects fly, the cuticle has to provide a very efficient and lightweight skeleton. Information is available about the mechanical properties of cuticle-Young's modulus of resilin is about 1 MPa, of soft cuticles about 1 kPa to 50 MPa, of sclerotised cuticles 1-20 GPa; Vicker's Hardness of sclerotised cuticle ranges between 25 and 80 kgf mm(-2); density is 1-1.3 kg m(-3)-and one of its components, chitin nanofibres, the Young's modulus of which is more than 150 GPa. Experiments based on fracture mechanics have not been performed although the layered structure probably provides some toughening. The structural performance of wings and legs has been measured, but our understanding of the importance of buckling is lacking: it can stiffen the structure (by elastic postbuckling in wings, for example) or be a failure mode. We know nothing of fatigue properties (yet, for instance, the insect wing must undergo millions of cycles, flexing or buckling on each cycle). The remarkable mechanical performance and efficiency of cuticle can be analysed and compared with those of other materials using material property charts and material indices. Presented in this paper are four: Young's modulus-density (stiffness per unit weight), specific Young's modulus-specific strength (elastic hinges, elastic energy storage per unit weight), toughness-Young's modulus (fracture resistance under various loading conditions), and hardness (wear resistance). In conjunction with a structural analysis of cuticle these charts help to understand the relevance of microstructure (fibre orientation effects in tendons, joints and sense organs, for example) and shape (including surface structure) of this fibrous composite for a given function. With modern techniques for analysis of structure and material, and emphasis on nanocomposites and self-assembly, insect cuticle should be the archetype for composites at all levels of scale.

  5. Validation of scaffold design optimization in bone tissue engineering: finite element modeling versus designed experiments.

    Science.gov (United States)

    Uth, Nicholas; Mueller, Jens; Smucker, Byran; Yousefi, Azizeh-Mitra

    2017-02-21

    This study reports the development of biological/synthetic scaffolds for bone tissue engineering (TE) via 3D bioplotting. These scaffolds were composed of poly(L-lactic-co-glycolic acid) (PLGA), type I collagen, and nano-hydroxyapatite (nHA) in an attempt to mimic the extracellular matrix of bone. The solvent used for processing the scaffolds was 1,1,1,3,3,3-hexafluoro-2-propanol. The produced scaffolds were characterized by scanning electron microscopy, microcomputed tomography, thermogravimetric analysis, and unconfined compression test. This study also sought to validate the use of finite-element optimization in COMSOL Multiphysics for scaffold design. Scaffold topology was simplified to three factors: nHA content, strand diameter, and strand spacing. These factors affect the ability of the scaffold to bear mechanical loads and how porous the structure can be. Twenty four scaffolds were constructed according to an I-optimal, split-plot designed experiment (DE) in order to generate experimental models of the factor-response relationships. Within the design region, the DE and COMSOL models agreed in their recommended optimal nHA (30%) and strand diameter (460 μm). However, the two methods disagreed by more than 30% in strand spacing (908 μm for DE; 601 μm for COMSOL). Seven scaffolds were 3D-bioplotted to validate the predictions of DE and COMSOL models (4.5-9.9 MPa measured moduli). The predictions for these scaffolds showed relative agreement for scaffold porosity (mean absolute percentage error of 4% for DE and 13% for COMSOL), but were substantially poorer for scaffold modulus (51% for DE; 21% for COMSOL), partly due to some simplifying assumptions made by the models. Expanding the design region in future experiments (e.g., higher nHA content and strand diameter), developing an efficient solvent evaporation method, and exerting a greater control over layer overlap could allow developing PLGA-nHA-collagen scaffolds to meet the mechanical requirements for

  6. Creating and validating GIS measures of urban design for health research.

    Science.gov (United States)

    Purciel, Marnie; Neckerman, Kathryn M; Lovasi, Gina S; Quinn, James W; Weiss, Christopher; Bader, Michael D M; Ewing, Reid; Rundle, Andrew

    2009-12-01

    Studies relating urban design to health have been impeded by the unfeasibility of conducting field observations across large areas and the lack of validated objective measures of urban design. This study describes measures for five dimensions of urban design - imageability, enclosure, human scale, transparency, and complexity - created using public geographic information systems (GIS) data from the US Census and city and state government. GIS measures were validated for a sample of 588 New York City block faces using a well-documented field observation protocol. Correlations between GIS and observed measures ranged from 0.28 to 0.89. Results show valid urban design measures can be constructed from digital sources.

  7. Development and Validation of a Rubric for Diagnosing Students' Experimental Design Knowledge and Difficulties.

    Science.gov (United States)

    Dasgupta, Annwesa P; Anderson, Trevor R; Pelaez, Nancy

    2014-01-01

    It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students' responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students' experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. © 2014 A. P. Dasgupta et al. CBE—Life Sciences Education © 2014 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  8. Structural exploration for the refinement of anticancer matrix metalloproteinase-2 inhibitor designing approaches through robust validated multi-QSARs

    Science.gov (United States)

    Adhikari, Nilanjan; Amin, Sk. Abdul; Saha, Achintya; Jha, Tarun

    2018-03-01

    Matrix metalloproteinase-2 (MMP-2) is a promising pharmacological target for designing potential anticancer drugs. MMP-2 plays critical functions in apoptosis by cleaving the DNA repair enzyme namely poly (ADP-ribose) polymerase (PARP). Moreover, MMP-2 expression triggers the vascular endothelial growth factor (VEGF) having a positive influence on tumor size, invasion, and angiogenesis. Therefore, it is an urgent need to develop potential MMP-2 inhibitors without any toxicity but better pharmacokinetic property. In this article, robust validated multi-quantitative structure-activity relationship (QSAR) modeling approaches were attempted on a dataset of 222 MMP-2 inhibitors to explore the important structural and pharmacophoric requirements for higher MMP-2 inhibition. Different validated regression and classification-based QSARs, pharmacophore mapping and 3D-QSAR techniques were performed. These results were challenged and subjected to further validation to explain 24 in house MMP-2 inhibitors to judge the reliability of these models further. All these models were individually validated internally as well as externally and were supported and validated by each other. These results were further justified by molecular docking analysis. Modeling techniques adopted here not only helps to explore the necessary structural and pharmacophoric requirements but also for the overall validation and refinement techniques for designing potential MMP-2 inhibitors.

  9. Microbial production of polyhydroxybutyrate with tailor-made properties: an integrated modelling approach and experimental validation.

    Science.gov (United States)

    Penloglou, Giannis; Chatzidoukas, Christos; Kiparissides, Costas

    2012-01-01

    The microbial production of polyhydroxybutyrate (PHB) is a complex process in which the final quantity and quality of the PHB depend on a large number of process operating variables. Consequently, the design and optimal dynamic operation of a microbial process for the efficient production of PHB with tailor-made molecular properties is an extremely interesting problem. The present study investigates how key process operating variables (i.e., nutritional and aeration conditions) affect the biomass production rate and the PHB accumulation in the cells and its associated molecular weight distribution. A combined metabolic/polymerization/macroscopic modelling approach, relating the process performance and product quality with the process variables, was developed and validated using an extensive series of experiments and measurements. The model predicts the dynamic evolution of the biomass growth, the polymer accumulation, the consumption of carbon and nitrogen sources and the average molecular weights of the PHB in a bioreactor, under batch and fed-batch operating conditions. The proposed integrated model was used for the model-based optimization of the production of PHB with tailor-made molecular properties in Azohydromonas lata bacteria. The process optimization led to a high intracellular PHB accumulation (up to 95% g of PHB per g of DCW) and the production of different grades (i.e., different molecular weight distributions) of PHB. Copyright © 2011 Elsevier Inc. All rights reserved.

  10. Validation of the Intestinal Part of the Prostate Cancer Questionnaire 'QUFW94': Psychometric Properties, Responsiveness, and Content Validity

    International Nuclear Information System (INIS)

    Reidunsdatter, Randi J.; Lund, Jo-Asmund; Fransson, Per; Widmark, Anders

    2010-01-01

    Purpose: Several treatment options are available for patients with prostate cancer. Applicable and valid self-assessment instruments for assessing health-related quality of life (HRQOL) are of paramount importance. The aim of this study was to explore the validity and responsiveness of the intestinal part of the prostate cancer-specific questionnaire QUFW94. Methods and Materials: The content of the intestinal part of QUFW94 was examined by evaluation of experienced clinicians and reviewing the literature. The psychometric properties and responsiveness were assessed by analyzing HRQOL data from the randomized study Scandinavian Prostate Cancer Group 7 (SPCG)/Swedish Association for Urological Oncology 3 (SFUO). Subscales were constructed by means of exploratory factor analyses. Internal consistency was assessed by Cronbach's alpha. Responsiveness was investigated by comparing baseline scores with the 4-year posttreatment follow-up. Results: The content validity was found acceptable, but some amendments were proposed. The factor analyses revealed two symptom scales. The first scale comprised five items regarding general stool problems, frequency, incontinence, need to plan toilet visits, and daily activity. Cronbach's alpha at 0.83 indicated acceptable homogeneity. The second scale was less consistent with a Cronbach's alpha at 0.55. The overall responsiveness was found to be very satisfactory. Conclusion: Two scales were identified in the bowel dimension of the QUFW94; the first one had good internal consistency. The responsiveness was excellent, and some modifications are suggested to strengthen the content validity.

  11. Organic bulk heterojunction photovoltaic structures: design, morphology and properties

    International Nuclear Information System (INIS)

    Bulavko, G V; Ishchenko, A A

    2014-01-01

    Main approaches to the design of organic bulk heterojunction photovoltaic structures are generalized and systematized. Novel photovoltaic materials based on fullerenes, organic dyes and related compounds, graphene, conjugated polymers and dendrimers are considered. The emphasis is placed on correlations between the chemical structure and properties of materials. The effect of morphology of the photoactive layer on the photovoltaic properties of devices is analyzed. Main methods of optimization of the photovoltaic properties are outlined. The bibliography includes 338 references

  12. Design and validation of inert homemade explosive simulants for X-ray-based inspection systems

    Science.gov (United States)

    Faust, Anthony A.; Nacson, Sabatino; Koffler, Bruce; Bourbeau, Éric; Gagne, Louis; Laing, Robin; Anderson, C. J.

    2014-05-01

    Transport Canada (TC), the Canadian Armed Forces, and other public security agencies have an interest in the assessment of the potential utility of advanced explosives detection technologies to aid in the detection and interdiction of commercial grade, military grade, and homemade or improvised explosives (HME or IE). The availability of suitable, non-hazardous, non-toxic, explosive simulants is of concern when assessing the potential utility of such detection systems. Lack of simulants limits the training opportunities, and ultimately the detection probability, of security personnel using these systems. While simulants for commercial and military grade explosives are available for a wide variety of detection technologies, the design and production of materials to simulate improvised explosives has not kept pace with this emerging threat. Funded by TC and the Canadian Safety and Security Program, Defence Research and Development Canada (DRDC), Visiontec Systems, and Optosecurity engaged in an effort to develop inert, non-toxic Xray interrogation simulants for IE materials such as ammonium nitrate, potassium chlorate, and triacetone triperoxide. These simulants were designed to mimic key X-ray interrogation-relevant material properties of real improvised explosives, principally their bulk density and effective atomic number. Different forms of the simulants were produced and tested, simulating the different explosive threat formulations that could be encountered by front line security workers. These simulants comply with safety and stability requirements, and as best as possible match form and homogeneity. This paper outlines the research program, simulant design, and validation.

  13. Design and validation of a uniform flow microreactor

    Energy Technology Data Exchange (ETDEWEB)

    Yi, Seung Jae; Kim, Kyung Chun; Chang, Seung Cheol [Pusan National University, Busan (Korea, Republic of); Park, Ji Min [Global HQ, Hankook Tire Co., Daejeon (Korea, Republic of)

    2014-01-15

    We present a design method to characterize uniform flows in a microreactor for high performance surface plasmon resonance (SPR) a general-purpose biosensor chips. The shape of the microreactor is designed based on an approximate pressure drop model. The number of micro-pillars and the slopes of the inlet and outlet linear chambers are two dominant parameters used to minimize the velocity difference in the microreactor. The flow uniformity was examined quantitatively by numerical and experimental visualization methods. A computational fluid dynamics (CFD) analysis demonstrates that the designed microreactor has a fairly uniform velocity profile in the reaction zone for a wide range of flow rates. The velocity field in the fabricated microreactor was measured using the micro-particle image velocimetry (μ-PIV) method, and the flow uniformity was confirmed experimentally. The performance of the uniform flow microreactor was verified using the fluorescence antibody technique.

  14. Design and validation of a cardiorespiratory capacity test for ...

    African Journals Online (AJOL)

    11.00 months), that were randomly selected from three schools in the southeast of Spain participated in this study. The 10x20m test was designed to evaluate aerobic endurance. The 6-minute walk test (6MWT) was selected and used for ...

  15. On various metrics used for validation of predictive QSAR models with applications in virtual screening and focused library design.

    Science.gov (United States)

    Roy, Kunal; Mitra, Indrani

    2011-07-01

    Quantitative structure-activity relationships (QSARs) have important applications in drug discovery research, environmental fate modeling, property prediction, etc. Validation has been recognized as a very important step for QSAR model development. As one of the important objectives of QSAR modeling is to predict activity/property/toxicity of new chemicals falling within the domain of applicability of the developed models and QSARs are being used for regulatory decisions, checking reliability of the models and confidence of their predictions is a very important aspect, which can be judged during the validation process. One prime application of a statistically significant QSAR model is virtual screening for molecules with improved potency based on the pharmacophoric features and the descriptors appearing in the QSAR model. Validated QSAR models may also be utilized for design of focused libraries which may be subsequently screened for the selection of hits. The present review focuses on various metrics used for validation of predictive QSAR models together with an overview of the application of QSAR models in the fields of virtual screening and focused library design for diverse series of compounds with citation of some recent examples.

  16. Quantification of construction waste prevented by BIM-based design validation: Case studies in South Korea.

    Science.gov (United States)

    Won, Jongsung; Cheng, Jack C P; Lee, Ghang

    2016-03-01

    Waste generated in construction and demolition processes comprised around 50% of the solid waste in South Korea in 2013. Many cases show that design validation based on building information modeling (BIM) is an effective means to reduce the amount of construction waste since construction waste is mainly generated due to improper design and unexpected changes in the design and construction phases. However, the amount of construction waste that could be avoided by adopting BIM-based design validation has been unknown. This paper aims to estimate the amount of construction waste prevented by a BIM-based design validation process based on the amount of construction waste that might be generated due to design errors. Two project cases in South Korea were studied in this paper, with 381 and 136 design errors detected, respectively during the BIM-based design validation. Each design error was categorized according to its cause and the likelihood of detection before construction. The case studies show that BIM-based design validation could prevent 4.3-15.2% of construction waste that might have been generated without using BIM. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Validity and Psychometric Properties of Malay Translated Religious Orientation Scale-Revised among Malaysian Adult Samples

    OpenAIRE

    Mohammad Rahim Kamaluddin; Rohany Nasir; Wan Shahrazad Wan Sulaiman; Rozainee Khairudin; Zainah Ahmad Zamani

    2017-01-01

    Religious Orientation Scale-Revised (ROS-R) has been used increasingly as an important measure in psychology of religion based researches and widely administered in cross-cultural settings. Unfortunately, there is no valid and reliable ROS-R available in Malay language to assess religious orientations among Malaysians. With that in mind, the present study aims to validate and document the psychometric properties of Malay translated ROS-R (henceforth, M-ROS-R) among sample of Malay...

  18. [Design and validation of a brief questionnaire to assess young´s sexual knowledge].

    Science.gov (United States)

    Leon-Larios, Fátima; Gómez-Baya, Diego

    2018-06-01

    Only very few instruments have been developed to assess sexual knowledge and practices. Most of the research to date has been carried out with adolescent samples, but not with university students, who are also at a particularly risky stage. The aim of this study was to design and validate a brief questionnaire to assess young´s sexual knowledge, practices and behaviors to design health education programs in the university context. We created a specific questionnaire about sexual pattern in university adolescents and a brief questionnaire consisted of 9 items (true/false) about contraception, sexuality and sexual transmission diseases. We carried out a pilot study, reliability (KR-20) and validity analyses using factorial analysis and examining the association with other variables. 566 students from University of Seville participated during 2015/16. One item was eliminated because of comprehension (only 13.9% of correct answers) and weak or non significant associations (p more than 0.05). Finally, the scale was formed by 8 items and had good internal consistency reliability (KR-20 = 0.57), and both factorial and external validity reliability. A three-factor model showed good data fit, χ2 (14, N=566)=17.48, p= 0.232, Comparative Fit Index CFI = 0.97, root mean squared error of prediction RMSEA = 0.02. Participants with less knowledge about sexuality were whose did not receive any information (M=6.82, SD=1.41), without partner (M=6.87, SD=1.35), had an abortion (M=6.43, SD=1.95) and did not use any contraceptive method (M=6.66, SD=0.58) or coitus interruptus (M=6.55, SD=1.39), and had less sexual relationships, e.g., once or twice a year (M=6.49, SD=1.70). This questionnaire is a short instrument to assess students´ practices and knowledge about sexuality and contraception. The analyses of reliability and validity have shown the good psychometric properties of this instrument.

  19. LATUX: An Iterative Workflow for Designing, Validating, and Deploying Learning Analytics Visualizations

    Science.gov (United States)

    Martinez-Maldonado, Roberto; Pardo, Abelardo; Mirriahi, Negin; Yacef, Kalina; Kay, Judy; Clayphan, Andrew

    2015-01-01

    Designing, validating, and deploying learning analytics tools for instructors or students is a challenge that requires techniques and methods from different disciplines, such as software engineering, human-computer interaction, computer graphics, educational design, and psychology. Whilst each has established its own design methodologies, we now…

  20. Validity test of design calculations of a PGNAA setup

    International Nuclear Information System (INIS)

    Naqvi, A.A.; Garwan, M.A.

    2004-01-01

    A rectangular moderator has been designed for the prompt gamma ray neutron activation analysis (PGNAA) setup at King Fahd University of Petroleum and Minerals (KFUPM) to analyze Portland cement samples. The design of the moderator assembly was obtained using Monte Carlo calculations. The design calculations of the new rectangular moderator of the KFUPM PGNAA setup have been verified experimentally through prompt gamma ray yield measurement as a function of the front moderator thickness. In this study the yield of the 3.54 and 4.94 MeV prompt gamma rays from silicon in a soil sample was measured as a function of thickness of the front moderator of the rectangular moderator. The experimental results were compared with the results of the Monte Carlo simulations. A good agreement has been achieved between the experimental results and the results of the calculations. The experimental results have provided useful information about the PGNAA setup performance, neutron moderation, and gamma ray attenuation in the PGNAA sample

  1. Validated design of the ITER main vacuum pumping systems

    International Nuclear Information System (INIS)

    Day, Chr.; Antipenkov, A.; Dremel, M.; Haas, H.; Hauer, V.; Mack, A.; Boissin, J.-C.; Class, G.; Murdoch, D.K.; Wykes, M.

    2005-01-01

    Forschungszentrum Karlsruhe is developing the ITER high vacuum cryogenic pumping systems (torus, cryostat, NBI) as well as the corresponding mechanical roughing pump trains. All force-cooled big cryopumps incorporate similar design of charcoal coated cryopanels cooled to 5 K with supercritical helium. A model of the torus exhaust cryopump was comprehensively characterised in the TIMO testbed at Forschungszentrum. This paper discusses the vacuum performance results of the model pump and outlines how these data were incorporated in a sound design of the whole ITER torus exhaust pumping system. To do this, the dedicated software package ITERVAC was developed which is able to describe gas flow in viscous, transitional and molecular flow regimes as needed for the gas coming through the divertor slots and along the pump ducts into the cryopumps. The entrance section between the divertor cassettes and each pumping duct was identified to be the bottleneck of the gas flow. The interrelation of achievable throughputs as a function of the divertor pressure and the cryopump pumping speed is discussed. The system design is completed by assessment of the NBI cryopump system and integrating performance curves for the roughing pump trains needed during the regeneration phases of the cryopumps. (author)

  2. Measuring Children’s Perceptions of Robots’ Social Competence : Design and Validation

    NARCIS (Netherlands)

    Davison, Daniel Patrick; Charisi, Vasiliki; Wijnen, Frances Martine; Reidsma, Dennis; Evers, Vanessa; Kheddar, Abderrahmane; Yoshida, Eiichi; Ge, Shuzhi Sam; Suzuki, Kenji; Cabibihan, John-John; Eyssel, Friederike; He, Hongsheng

    2017-01-01

    This paper presents the design and validation of a measurement instrument for children’s perceptions of robots’ social competence. The need for a standardized validated instrument has emerged as a requisite for meta-analyses and comparisons among various studies in the field of child-robot

  3. Bone biopsy needles. Mechanical properties, needle design and specimen quality

    International Nuclear Information System (INIS)

    Keulers, Annika; Penzkofer, T.; Cunha-Cruz, V.C.; Bruners, P.; Helmholtz Inst. fuer biomedizinische Technik, Aachen; Braunschweig, T.; Schmitz-Rode, T.; Mahnken, A.; Helmholtz Inst. fuer biomedizinische Technik, Aachen

    2011-01-01

    To quantitatively analyze differences in mechanical properties, needle design including signs of wear, subjective handling and specimen quality of bone biopsy needles. Materials and Methods: In this study 19 different bone biopsy systems (total 38; 2 /type) were examined. With each biopsy needle five consecutive samples were obtained from vertebral bodies of swine. During puncture a force-torques sensor measured the mechanical properties and subjective handling was assessed. Before and after each biopsy the needles were investigated using a profile projector and signs of wear were recorded. Afterwards, a pathologist semi-quantitatively examined the specimen regarding sample quality. The overall evaluation considered mechanical properties, needle wear, subjective handling and sample quality. Differences were assessed for statistical significance using ANOVA and t-test. Results: Needle diameter (p = 0.003) as well as needle design (p = 0.008) affect the mechanical properties significantly. Franseen design is significantly superior to other needle designs. Besides, length reduction recorded by the profile projector, as a quality criterion showed notable distinctions in between the needle designs. Conclusion: Bone biopsy needles vary significantly in performance. Needle design has an important influence on mechanical properties, handling and specimen quality. Detailed knowledge of those parameters would improve selecting the appropriate bone biopsy needle. (orig.)

  4. Valid knowledge for the professional design of large and complex design processes

    NARCIS (Netherlands)

    Aken, van J.E.

    2004-01-01

    The organization and planning of design processes, which we may regard as design process design, is an important issue. Especially for large and complex design-processes traditional approaches to process design may no longer suffice. The design literature gives quite some design process models. As

  5. Design, construction, and validation of a scale to measure cyberbullying in a work environment

    Directory of Open Access Journals (Sweden)

    Luz N. Fernández-López

    2018-04-01

    Full Text Available The objective of this study was to design, construct, and validate a scale to measure cyberbullying in a work environment. The design used was quantitative, not experimental, and transversal. The research method was based on the Reactive Response Theory. This research produced a validated scale with a sample of the work environment in Puerto Rico. Three analyses were performed: content validity, reliability analysis of the Cronbach alpha coefficient, and the divergent type construct validity. Based on the analysis of the results, the scale was deemed to be useful for the purpose it was designed. Building a scale that measures cyberbullying contributes to the design of new instruments and the revision of existing ones; furthermore, it may serve as the basis for future re- search related to the topic of cyberbullying.

  6. Design verification and validation plan for the cold vacuum drying facility

    International Nuclear Information System (INIS)

    NISHIKAWA, L.D.

    1999-01-01

    The Cold Vacuum Drying Facility (CVDF) provides the required process systems, supporting equipment, and facilities needed for drying spent nuclear fuel removed from the K Basins. This document presents the both completed and planned design verification and validation activities

  7. Property Based Process and Product Synthesis and Design

    DEFF Research Database (Denmark)

    Eden, Mario Richard

    2003-01-01

    in terms of the constitutive (synthesis/design) variables instead of the process variables, thus providing the synthesis/design targets. The second reverse problem (reverse property prediction) solves the constitutive equations to identify unit operations, operating conditions and/or products by matching......This thesis describes the development of a general framework for solving process and product design problems. Targeting the desired performance of the system in a systematic manner relieves the iterative nature of conventional design techniques. Furthermore, conventional component based methods...... are not capable of handling problems, where the process or product objectives are driven by functionalities or properties rather than chemical constituency. The framework is meant to complement existing composition based methods by being able to handle property driven problems. By investigating the different...

  8. Evaluation of RF properties by orifice design for IFMIF RFQ

    International Nuclear Information System (INIS)

    Maebara, Sunao; Sugimoto, Masayoshi

    2005-03-01

    Orifices for the IFMIF RFQ have been designed and fabricated, and RF properties have been evaluated by a network analyzer. The designed orifices were installed into a vacuum port of the 1.1m-long RFQ mock-up module, and the resonant frequency and the phase difference between cavities were measured for a quadrupole operation mode of TE 210 . It was found that the RF properties are not affected on condition that slit direction with the same direction of current flow at the RFQ wall. Orifice conductance from 0.22 to 0.25 m 3 /sec by nitrogen conversion at room temperature was designed, and an ultimate pressure level of 5x10 -7 [Pa] was evaluated for the 4.1m-long central module for the IFMIF RFQ. It was concluded that the designed orifices are effective for RF properties and vacuum conductance in the IFMIF RFQ. (author)

  9. Design and Validation with Measurements of the LEIR Injection Line

    CERN Document Server

    Roncarolo, F; Chanel, M; Dumas, L; Scrivens, R

    2006-01-01

    The CERN Low Energy Ion Ring (LEIR) commissioning started in the year 2005. O4+and Pb54+ion beams are transferred at 4.2 MeV/nucleon from Linac 3 to LEIR through a low energy transfer line, for which the constraints and the resulting optics design are presented. First trajectory and dispersion measurements agreed only poorly with the theoretical model. Iterations of a refined optics model and further measurements improved the agreement between experimental observations and expectations. In particular, the effect of quadrupole errors in the line dipole magnets is discussed.

  10. Design description and validation results for the IFMIF High Flux Test Module as outcome of the EVEDA phase

    Directory of Open Access Journals (Sweden)

    F. Arbeiter

    2016-12-01

    Full Text Available During the Engineering Validation and Engineering Design Activities (EVEDA phase (2007-2014 of the International Fusion Materials Irradiation Facility (IFMIF, an advanced engineering design of the High Flux Test Module (HFTM has been developed with the objective to facilitate the controlled irradiation of steel samples in the high flux area directly behind the IFMIF neutron source. The development process addressed included manufacturing techniques, CAD, neutronic, thermal-hydraulic and mechanical analyses complemented by a series of validation activities. Validation included manufacturing of 1:1 parts and mockups, test of prototypes in the FLEX and HELOKA-LP helium loops of KIT for verification of the thermal and mechanical properties, and irradiation of specimen filled capsule prototypes in the BR2 test reactor. The prototyping activities were backed by several R&D studies addressing focused issues like handling of liquid NaK (as filling medium and insertion of Small Specimen Test Technique (SSTT specimens into the irradiation capsules. This paper provides an up-todate design description of the HFTM irradiation device, and reports on the achieved performance criteria related to the requirements. Results of the validation activities are accounted for and the most important issues for further development are identified.

  11. Design and validation of a Cannabis Use Intention Questionnaire (CUIQ) for adolescents.

    Science.gov (United States)

    Lloret Irles, Daniel; Morell-Gomis, Ramón; Laguía, Ana; Moriano, Juan A

    2018-01-01

    In Spain, one in four 14 to 18-year-old adolescents has used cannabis during the last twelve months. Demand for treatment has increased in European countries. These facts have prompted the development of preventive interventions that require screening tools in order to identify the vulnerable population and to properly asses the efficacy of such interventions. The Theory of Planned Behaviour (TPB), widely used to forecast behavioural intention, has also demonstrated a good predictive capacity in addictions. The aim of this study is to design and validate a Cannabis Use Intention Questionnaire (CUIQ) based on TPB. 1,011 teenagers answered a set of tests to assess attitude towards use, subjective norms, self-efficacy towards non-use, and intention to use cannabis. CUIQ had good psychometric properties. Structural Equation Modelling results confirm the predictive model on intention to use cannabis in the Spanish adolescent sample, classified as users and non-users, explaining 40% of variance of intention to consume. CUIQ is aimed at providing a better understanding of the psychological processes that lead to cannabis use and allowing the evaluation of programmes. This can be particularly useful for improving the design and implementation of selective prevention programmes.

  12. Predicting Silk Fiber Mechanical Properties through Multiscale Simulation and Protein Design.

    Science.gov (United States)

    Rim, Nae-Gyune; Roberts, Erin G; Ebrahimi, Davoud; Dinjaski, Nina; Jacobsen, Matthew M; Martín-Moldes, Zaira; Buehler, Markus J; Kaplan, David L; Wong, Joyce Y

    2017-08-14

    Silk is a promising material for biomedical applications, and much research is focused on how application-specific, mechanical properties of silk can be designed synthetically through proper amino acid sequences and processing parameters. This protocol describes an iterative process between research disciplines that combines simulation, genetic synthesis, and fiber analysis to better design silk fibers with specific mechanical properties. Computational methods are used to assess the protein polymer structure as it forms an interconnected fiber network through shearing and how this process affects fiber mechanical properties. Model outcomes are validated experimentally with the genetic design of protein polymers that match the simulation structures, fiber fabrication from these polymers, and mechanical testing of these fibers. Through iterative feedback between computation, genetic synthesis, and fiber mechanical testing, this protocol will enable a priori prediction capability of recombinant material mechanical properties via insights from the resulting molecular architecture of the fiber network based entirely on the initial protein monomer composition. This style of protocol may be applied to other fields where a research team seeks to design a biomaterial with biomedical application-specific properties. This protocol highlights when and how the three research groups (simulation, synthesis, and engineering) should be interacting to arrive at the most effective method for predictive design of their material.

  13. Domestic design and validation of natural circulation steam generator of China 1000 MWe PWR NPP

    International Nuclear Information System (INIS)

    Liu, H.Y.; Wang, X.Y.; Wu, G.; Qin, J.M.; Xiong, Ch.H.; Wang, W.; Chen, J.L.; Cheng, H.P.; Zuo, Ch.P.

    2005-01-01

    In order to meet the requirements of domestic design of China intending built NPP projects, Research Institute of Nuclear Power Operation (RINPO) has achieved design of 1000 MWe NPP steam generator, called RINSG-1000(means 1000MWe SG designed by RINPO), which is based on SG research ,experiments and service experience accumulated by RINPO in more 40 years. Testing validation of two steam generator key technologies, advanced moisture separate device and sludge collector, has been accomplished during the period of 2000 to 2002. This paper describes the design features of RINSG-1000, and provides some validation test results. (authors)

  14. BICYCLE HELMET DESIGN AND THE VIRTUAL VALIDATION OF THE IMPACT, AERODYNAMICS AND PRODUCTION PROCESS

    Directory of Open Access Journals (Sweden)

    Bojan Boshevski

    2017-12-01

    Full Text Available This paper presents the development process of a bicycle helmet through individual research, creation, presentation and analysis of the results of the most important product development stages. The quality of the development and manufacturing process of the protective equipment for extreme sports is an imperative for a successful product and its flawless function. The design of the bicycle helmet is made following the rules of the design in order to create a well-founded and functional product. After creating design sketches, a virtual prototype was developed in "SolidWorks" using the required ergonomic dimensions. 3D printed model of the human head with adapted ergonomic dimensions and the designed bicycle helmet was developed in order to verify the applied ergonomic measures. The virtual model will be used as an input in the finite element analysis of the helmet impact test based on the EN1078 standard and the aerodynamic simulations executed in "SolidWorks Simulation and Flow Simulation", for verification of the impact and aerodynamic properties. Virtual testing of aerodynamic features and the ability of the bicycle helmet to allow ventilation of the user's head indicate that the helmet performs its function in the desired way. Also, the virtual prototype will be used for the production process simulation in "SolidWorks Plastics" in order to analyze the production of the bicycle helmet. The polycarbonate helmet outer shell is subject to a number of simulations for the sake of analyzing the production process in order to obtain the desired characteristics of the polycarbonate outer shell and to avoid the disadvantages that occur in the manufacturing process. The main goal of this paper is to develop a safety bicycle helmet with improved ergonomic, validation of impact, aerodynamic characteristics and production process in order to produce a high quality product for mass use.

  15. Development and validation of a questionnaire designed to measure foot-health status.

    Science.gov (United States)

    Bennett, P J; Patterson, C; Wearing, S; Baglioni, T

    1998-09-01

    The aim of this study was to apply the principles of content, criterion, and construct validation to a new questionnaire specifically designed to measure foot-health status. One hundred eleven subjects completed two different questionnaires designed to measure foot health (the new Foot Health Status Questionnaire and the previously validated Foot Function Index) and underwent a clinical examination in order to provide data for a second-order confirmatory factor analysis. Presented herein is a psychometrically evaluated questionnaire that contains 13 items covering foot pain, foot function, footwear, and general foot health. The tool demonstrates a high degree of content, criterion, and construct validity and test-retest reliability.

  16. Design, Manufacture, and Experimental Serviceability Validation of ITER Blanket Components

    Science.gov (United States)

    Leshukov, A. Yu.; Strebkov, Yu. S.; Sviridenko, M. N.; Safronov, V. M.; Putrik, A. B.

    2017-12-01

    In 2014, the Russian Federation and the ITER International Organization signed two Procurement Arrangements (PAs) for ITER blanket components: 1.6.P1ARF.01 "Blanket First Wall" of February 14, 2014, and 1.6.P3.RF.01 "Blanket Module Connections" of December 19, 2014. The first PA stipulates development, manufacture, testing, and delivery to the ITER site of 179 Enhanced Heat Flux (EHF) First Wall (FW) Panels intended for withstanding the heat flux from the plasma up to 4.7MW/m2. Two Russian institutions, NIIEFA (Efremov Institute) and NIKIET, are responsible for the implementation of this PA. NIIEFA manufactures plasma-facing components (PFCs) of the EHF FW panels and performs the final assembly and testing of the panels, and NIKIET manufactures FW beam structures, load-bearing structures of PFCs, and all elements of the panel attachment system. As for the second PA, NIKIET is the sole official supplier of flexible blanket supports, electrical insulation key pads (EIKPs), and blanket module/vacuum vessel electrical connectors. Joint activities of NIKIET and NIIEFA for implementing PA 1.6.P1ARF.01 are briefly described, and information on implementation of PA 1.6.P3.RF.01 is given. Results of the engineering design and research efforts in the scope of the above PAs in 2015-2016 are reported, and results of developing the technology for manufacturing ITER blanket components are presented.

  17. Properties of Alloy 617 for Heat Exchanger Design

    International Nuclear Information System (INIS)

    Wright, R.N.; Carroll, L.J.; Benz, J.K.; Wright, J.K.; Lillo, T.M.; Lybeck, N.J.

    2014-01-01

    Alloy 617 is among the primary candidates for very high temperature reactor heat exchangers anticipated for use up to 950ºC. Elevated temperature properties of this alloy and the mechanisms responsible for the observed tensile, creep and creep-fatigue behavior have been characterized over a wide range of test temperatures up to 1000ºC. Properties from the current experimental program have been combined with archival information from previous VHTR research to provide large data sets for many heats of material, product forms, and weldments. The combined data have been analyzed to determine conservative values of yield and tensile strength, strain rate sensitivity, creep-rupture behavior, fatigue and creep- fatigue properties that can be used for engineering design of reactor components. Phenomenological models have been developed to bound the regions over which the engineering properties are well known or can be confidently extrapolated for use in design. (author)

  18. Rationally designed synthetic protein hydrogels with predictable mechanical properties.

    Science.gov (United States)

    Wu, Junhua; Li, Pengfei; Dong, Chenling; Jiang, Heting; Bin Xue; Gao, Xiang; Qin, Meng; Wang, Wei; Bin Chen; Cao, Yi

    2018-02-12

    Designing synthetic protein hydrogels with tailored mechanical properties similar to naturally occurring tissues is an eternal pursuit in tissue engineering and stem cell and cancer research. However, it remains challenging to correlate the mechanical properties of protein hydrogels with the nanomechanics of individual building blocks. Here we use single-molecule force spectroscopy, protein engineering and theoretical modeling to prove that the mechanical properties of protein hydrogels are predictable based on the mechanical hierarchy of the cross-linkers and the load-bearing modules at the molecular level. These findings provide a framework for rationally designing protein hydrogels with independently tunable elasticity, extensibility, toughness and self-healing. Using this principle, we demonstrate the engineering of self-healable muscle-mimicking hydrogels that can significantly dissipate energy through protein unfolding. We expect that this principle can be generalized for the construction of protein hydrogels with customized mechanical properties for biomedical applications.

  19. Properties of Alloy 617 for Heat Exchanger Design

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Richard Neil [Idaho National Laboratory; Carroll, Laura Jill [Idaho National Laboratory; Benz, Julian Karl [Idaho National Laboratory; Wright, Julie Knibloe [Idaho National Laboratory; Lillo, Thomas Martin [Idaho National Laboratory; Lybeck, Nancy Jean [Idaho National Laboratory

    2014-10-01

    Abstract – Alloy 617 is among the primary candidates for very high temperature reactor heat exchangers anticipated for use up to 950ºC. Elevated temperature properties of this alloy and the mechanisms responsible for the observed tensile, creep and creep-fatigue behavior have been characterized over a wide range of test temperatures up to 1000ºC. Properties from the current experimental program have been combined with archival information from previous VHTR research to provide large data sets for many heats of material, product forms, and weldments. The combined data have been analyzed to determine conservative values of yield and tensile strength, strain rate sensitivity, creep-rupture behavior, fatigue and creep- fatigue properties that can be used for engineering design of reactor components. Phenomenological models have been developed to bound the regions over which the engineering properties are well known or can be confidently extrapolated for use in design.

  20. Physical Properties for Lipids Based Process and Product Design

    DEFF Research Database (Denmark)

    Ana Perederic, Olivia; Kalakul, Sawitree; Sarup, Bent

    Lipid processing covers several oil and fats technologies such as: edible oil production, biodieselproduction, oleochemicals (e.g.: food additives, detergents) and pharmaceutical product manufacturing. New demands regarding design and development of better products and more sustainable processes...... related to lipids technology, emerge according to consumers demanding improved product manufacturing from sustainable resources and new legislation regarding environmental safety [1]. Physical and thermodynamic property data and models for prediction of pure compound properties and mixtures properties...... involving lipids represent the basic and most important requirements for process product design, simulation and optimization. Experimentally measured values of involved compounds are desirable, but in most of the cases these are not available for all the compounds and properties needed. The lack...

  1. Designing Optical Properties in DNA-Programmed Nanoparticle Superlattices

    Science.gov (United States)

    Ross, Michael Brendan

    A grand challenge of modern science has been the ability to predict and design the properties of new materials. This approach to the a priori design of materials presents a number of challenges including: predictable properties of the material building blocks, a programmable means for arranging such building blocks into well understood architectures, and robust models that can predict the properties of these new materials. In this dissertation, we present a series of studies that describe how optical properties in DNA-programmed nanoparticle superlattices can be predicted prior to their synthesis. The first chapter provides a history and introduction to the study of metal nanoparticle arrays. Chapter 2 surveys and compares several geometric models and electrodynamics simulations with the measured optical properties of DNA-nanoparticle superlattices. Chapter 3 describes silver nanoparticle superlattices (rather than gold) and identifies their promise as plasmonic metamaterials. In chapter 4, the concept of plasmonic metallurgy is introduced, whereby it is demonstrated that concepts from materials science and metallurgy can be applied to the optical properties of mixed metallic plasmonic materials, unveiling rich and tunable optical properties such as color and asymmetric reflectivity. Chapter 5 presents a comprehensive theoretical exploration of anisotropy (non-spherical) in nanoparticle superlattice architectures. The role of anisotropy is discussed both on the nanoscale, where several desirable metamaterial properties can be tuned from the ultraviolet to near-infrared, and on the mesoscale, where the size and shape of a superlattice is demonstrated to have a pronounced effect on the observed far-field optical properties. Chapter 6 builds upon those theoretical data presented in chapter 5, including the experimental realization of size and shape dependent properties in DNA-programmed superlattices. Specifically, nanoparticle spacing is explored as a parameter that

  2. The validity of owner-reported property cost as a measure of ...

    African Journals Online (AJOL)

    The paucity of objective indicators of property values is pervasive in developing countries. This necessitates the use of proxy measures. However, there are huge gaps in knowledge on the validity of such measures. The main objective of the study reported here is to contribute to efforts aimed at closing these gaps. It does so ...

  3. Validation of forcefields in predicting the physical and thermophysical properties of emeraldine base polyaniline

    NARCIS (Netherlands)

    Chen, X.P.; Yuan, C.A.; Wong, C.K.Y.; Koh, S.W.; Zhang, G.Q.

    2011-01-01

    We report a molecular modelling study to validate the forcefields [condensed-phase optimised molecular potentials for atomistic simulation studies (COMPASS) and polymer-consistent forcefield (PCFF)] in predicting the physical and thermophysical properties of polymers. This work comprises of two key

  4. A Multimedia Child Developmental Screening Checklist: Design and Validation.

    Science.gov (United States)

    Cheng, Hsin-Yi Kathy; Chen, Li-Ying; Cheng, Chih-Hsiu; Ju, Yan-Ying; Chen, Chia-Ling; Tseng, Kevin C

    2016-10-24

    Identifying disability early in life confers long-term benefits for children. The Taipei City Child Development Screening tool, second version (Taipei II) provides checklists for 13 child age groups from 4 months to 6 years. However, the usability of a text-based screening tool largely depends on the literacy level and logical reasoning ability of the caregivers, as well as language barriers caused by increasing numbers of immigrants. The objectives of this study were to (1) design and develop a Web-based multimedia version of the current Taipei II developmental screening tool, and (2) investigate the measurement equivalence of this multimedia version to the original paper-based version. To develop the multimedia version of Taipei II, a team of experts created illustrations, translations, and dubbing of the original checklists. The developmental screening test was administered to a total of 390 primary caregivers of children aged between 4 months and 6 years. Psychometric testing revealed excellent agreement between the paper and multimedia versions of Taipei II. Good to excellent reliabilities were demonstrated for all age groups for both the cross-mode similarity (mode intraclass correlation range 0.85-0.96) and the test-retest reliability (r=.93). Regarding the usability, the mean score was 4.80 (SD 0.03), indicating that users were satisfied with their multimedia website experience. The multimedia tool produced essentially equivalent results to the paper-based tool. In addition, it had numerous advantages, such as it can facilitate active participation and promote early screening of target populations. Clinicaltrials.gov NCT02359591; https://clinicaltrials.gov/ct2/show/NCT02359591 (Archived by WebCite at http://www.webcitation.org/6l21mmdNn).

  5. Design, validation, and reliability of survey to measure female athlete triad knowledge among coaches

    Directory of Open Access Journals (Sweden)

    Jillian E. Frideres

    2015-06-01

    Full Text Available The purpose of this study was to design and to test the validity and reliability of an instrument to evaluate coaches' knowledge about the female athlete triad syndrome and their confidence in this knowledge. The instrument collects information regarding: knowledge of the syndrome, components, prevention and intervention; confidence of the coaches in their answers; and coach's characteristics (gender, degree held, years of experience in coaching females, continuing education participation specific to the syndrome and its components, and sport coached. The process of designing the questionnaire and testing the validity and reliability of it was done in four phases: a design and development of the instrument, b content validity, c instrument reliability, and d concurrent validity. The results show that the instrument is suitable for measuring coaches' female athlete triad knowledge. The instrument can contribute to assessing the coaches' knowledge level in relation to this topic.

  6. Design and validation of general biology learning program based on scientific inquiry skills

    Science.gov (United States)

    Cahyani, R.; Mardiana, D.; Noviantoro, N.

    2018-03-01

    Scientific inquiry is highly recommended to teach science. The reality in the schools and colleges is that many educators still have not implemented inquiry learning because of their lack of understanding. The study aims to1) analyze students’ difficulties in learning General Biology, 2) design General Biology learning program based on multimedia-assisted scientific inquiry learning, and 3) validate the proposed design. The method used was Research and Development. The subjects of the study were 27 pre-service students of general elementary school/Islamic elementary schools. The workflow of program design includes identifying learning difficulties of General Biology, designing course programs, and designing instruments and assessment rubrics. The program design is made for four lecture sessions. Validation of all learning tools were performed by expert judge. The results showed that: 1) there are some problems identified in General Biology lectures; 2) the designed products include learning programs, multimedia characteristics, worksheet characteristics, and, scientific attitudes; and 3) expert validation shows that all program designs are valid and can be used with minor revisions. The first section in your paper.

  7. [Design and validation of a questionnaire for psychosocial nursing diagnosis in Primary Care].

    Science.gov (United States)

    Brito-Brito, Pedro Ruymán; Rodríguez-Álvarez, Cristobalina; Sierra-López, Antonio; Rodríguez-Gómez, José Ángel; Aguirre-Jaime, Armando

    2012-01-01

    To develop a valid, reliable and easy-to-use questionnaire for a psychosocial nursing diagnosis. The study was performed in two phases: first phase, questionnaire design and construction; second phase, validity and reliability tests. A bank of items was constructed using the NANDA classification as a theoretical framework. Each item was assigned a Likert scale or dichotomous response. The combination of responses to the items constituted the diagnostic rules to assign up to 28 labels. A group of experts carried out the validity test for content. Other validated scales were used as reference standards for the criterion validity tests. Forty-five nurses provided the questionnaire to the patients on three separate occasions over a period of three weeks, and the other validated scales only once to 188 randomly selected patients in Primary Care centres in Tenerife (Spain). Validity tests for construct confirmed the six dimensions of the questionnaire with 91% of total variance explained. Validity tests for criterion showed a specificity of 66%-100%, and showed high correlations with the reference scales when the questionnaire was assigning nursing diagnoses. Reliability tests showed agreement of 56%-91% (PQuestionnaire for Psychosocial Nursing Diagnosis was called CdePS, and included 61 items. The CdePS is a valid, reliable and easy-to-use tool in Primary Care centres to improve the assigning of a psychosocial nursing diagnosis. Copyright © 2011 Elsevier España, S.L. All rights reserved.

  8. Psychometric properties including reliability, validity and responsiveness of the Majeed pelvic score in patients with chronic sacroiliac joint pain.

    Science.gov (United States)

    Bajada, Stefan; Mohanty, Khitish

    2016-06-01

    The Majeed scoring system is a disease-specific outcome measure that was originally designed to assess pelvic injuries. The aim of this study was to determine the psychometric properties of the Majeed scoring system for chronic sacroiliac joint pain. Internal consistency, content validity, criterion validity, construct validity and responsiveness to change was assessed prospectively for the Majeed scoring system in a cohort of 60 patients diagnosed with sacroiliac joint pain. This diagnosis was confirmed with CT-guided sacroiliac joint anaesthetic block. The overall Majeed score showed acceptable internal consistency (Cronbach alpha = 0.63). Similarly, it showed acceptable floor (0 %) and ceiling (0 %) effects. On the other hand, the domains of pain, work, sitting and sexual intercourse had high (>30 %) floor effects. Significant correlation with the physical component of the Short Form-36 (p = 0.005) and Oswestry disability index (p ≤ 0.001) was found indicating acceptable criterion validity. The overall Majeed score showed acceptable construct validity with all five developed hypotheses showing significance (p ≤ 0.05). The overall Majeed score showed acceptable responsiveness to change with a large (≥0.80) effect size and standardized response mean. Overall the Majeed scoring system demonstrated acceptable psychometric properties for outcome assessment in chronic sacroiliac joint pain. Thus, its use in this condition is adequate. However, some domains demonstrated suboptimal performance indicating that improvement might be achieved with the development of an outcome measure specific for sacroiliac joint dysfunction and degeneration.

  9. Further validation and definition of the psychometric properties of the Asthma Impact Survey.

    Science.gov (United States)

    Schatz, Michael; Zeiger, Robert S; Yang, Su-Jau; Chen, Wansu; Kosinski, Mark

    2011-07-01

    The Asthma Impact Survey (AIS-6) is a brief disease-specific quality-of-life instrument with limited published validation data. To obtain additional validation data and psychometric properties of the AIS-6. In November, 2007, patients with persistent asthma were mailed a survey that included the AIS-6, the mini-Asthma Quality of Life Questionnaire (mAQLQ), and the Asthma Control Test (ACT). Follow-up surveys were sent in April, July, and October 2008. Year 2008 exacerbations and short-acting β-agonist (SABA) dispensings were captured from administrative data. A total of 2680 patients had complete baseline survey data. Criterion validity was demonstrated by the strong correlations of the AIS-6 with the mAQLQ (r = -0.84 to -0.86); construct validity by significant relationships (P validity by significant relationships (P reliability (intraclass correlation coefficient = 0.86-0.91) were also demonstrated. The AIS-6 demonstrated good psychometric properties in a large independent sample and could be used to assess asthma-specific quality of life in clinical practice and clinical research. Copyright © 2011 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  10. Design validation of the ITER EC upper launcher according to codes and standards

    Energy Technology Data Exchange (ETDEWEB)

    Spaeh, Peter, E-mail: peter.spaeh@kit.edu [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Aiello, Gaetano [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Gagliardi, Mario [Karlsruhe Institute of Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); F4E, Fusion for Energy, Joint Undertaking, Barcelona (Spain); Grossetti, Giovanni; Meier, Andreas; Scherer, Theo; Schreck, Sabine; Strauss, Dirk; Vaccaro, Alessandro [Karlsruhe Institute of Technology, Institute for Applied Materials, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany); Weinhorst, Bastian [Karlsruhe Institute of Technology, Institute for Neutron Physics and Reactor Technology, Association KIT-EURATOM, P.O. Box 3640, D-76021 Karlsruhe (Germany)

    2015-10-15

    Highlights: • A set of applicable codes and standards has been chosen for the ITER EC upper launcher. • For a particular component load combinations, failure modes and stress categorizations have been determined. • The design validation was performed in accordance with the “design by analysis”-approach of the ASME boiler and pressure vessel code section III. - Abstract: The ITER electron cyclotron (EC) upper launcher has passed the CDR (conceptual design review) in 2005 and the PDR (preliminary design review) in 2009 and is in its final design phase now. The final design will be elaborated by the European consortium ECHUL-CA with contributions from several research institutes in Germany, Italy, the Netherlands and Switzerland. Within this consortium KIT is responsible for the design of the structural components (the upper port plug, UPP) and also the design integration of the launcher. As the selection of applicable codes and standards was under discussion for the past decade, the conceptual and the preliminary design of the launcher structure were not elaborated in straight accordance with a particular code but with a variety of well-acknowledged engineering practices. For the final design it is compulsory to validate the design with respect to a typical engineering code in order to be compliant with the ITER quality and nuclear requirements and to get acceptance from the French regulator. This paper presents typical design validation of the closure plate, which is the vacuum and Tritium barrier and thus a safety relevant component of the upper port plug (UPP), performed with the ASME boiler and pressure vessel code. Rationales for choosing this code are given as well as a comparison between different design methods, like the “design by rule” and the “design by analysis” approach. Also the selections of proper load specifications and the identification of potential failure modes are covered. In addition to that stress categorizations, analyses

  11. Design validation of the ITER EC upper launcher according to codes and standards

    International Nuclear Information System (INIS)

    Spaeh, Peter; Aiello, Gaetano; Gagliardi, Mario; Grossetti, Giovanni; Meier, Andreas; Scherer, Theo; Schreck, Sabine; Strauss, Dirk; Vaccaro, Alessandro; Weinhorst, Bastian

    2015-01-01

    Highlights: • A set of applicable codes and standards has been chosen for the ITER EC upper launcher. • For a particular component load combinations, failure modes and stress categorizations have been determined. • The design validation was performed in accordance with the “design by analysis”-approach of the ASME boiler and pressure vessel code section III. - Abstract: The ITER electron cyclotron (EC) upper launcher has passed the CDR (conceptual design review) in 2005 and the PDR (preliminary design review) in 2009 and is in its final design phase now. The final design will be elaborated by the European consortium ECHUL-CA with contributions from several research institutes in Germany, Italy, the Netherlands and Switzerland. Within this consortium KIT is responsible for the design of the structural components (the upper port plug, UPP) and also the design integration of the launcher. As the selection of applicable codes and standards was under discussion for the past decade, the conceptual and the preliminary design of the launcher structure were not elaborated in straight accordance with a particular code but with a variety of well-acknowledged engineering practices. For the final design it is compulsory to validate the design with respect to a typical engineering code in order to be compliant with the ITER quality and nuclear requirements and to get acceptance from the French regulator. This paper presents typical design validation of the closure plate, which is the vacuum and Tritium barrier and thus a safety relevant component of the upper port plug (UPP), performed with the ASME boiler and pressure vessel code. Rationales for choosing this code are given as well as a comparison between different design methods, like the “design by rule” and the “design by analysis” approach. Also the selections of proper load specifications and the identification of potential failure modes are covered. In addition to that stress categorizations, analyses

  12. Improving Coastal Ocean Color Validation Capabilities through Application of Inherent Optical Properties (IOPs)

    Science.gov (United States)

    Mannino, Antonio

    2008-01-01

    Understanding how the different components of seawater alter the path of incident sunlight through scattering and absorption is essential to using remotely sensed ocean color observations effectively. This is particularly apropos in coastal waters where the different optically significant components (phytoplankton, detrital material, inorganic minerals, etc.) vary widely in concentration, often independently from one another. Inherent Optical Properties (IOPs) form the link between these biogeochemical constituents and the Apparent Optical Properties (AOPs). understanding this interrelationship is at the heart of successfully carrying out inversions of satellite-measured radiance to biogeochemical properties. While sufficient covariation of seawater constituents in case I waters typically allows empirical algorithms connecting AOPs and biogeochemical parameters to behave well, these empirical algorithms normally do not hold for case I1 regimes (Carder et al. 2003). Validation in the context of ocean color remote sensing refers to in-situ measurements used to verify or characterize algorithm products or any assumption used as input to an algorithm. In this project, validation capabilities are considered those measurement capabilities, techniques, methods, models, etc. that allow effective validation. Enhancing current validation capabilities by incorporating state-of-the-art IOP measurements and optical models is the purpose of this work. Involved in this pursuit is improving core IOP measurement capabilities (spectral, angular, spatio-temporal resolutions), improving our understanding of the behavior of analytical AOP-IOP approximations in complex coastal waters, and improving the spatial and temporal resolution of biogeochemical data for validation by applying biogeochemical-IOP inversion models so that these parameters can be computed from real-time IOP sensors with high sampling rates. Research cruises supported by this project provides for collection and

  13. Design, properties, and applications of protein micro- and nanoparticles

    NARCIS (Netherlands)

    Saglam, Dilek; Venema, Paul; van der Linden, Erik; de Vries, Renko

    2014-01-01

    The design of protein particles with tailored properties has received an increased attention recently. Several approaches, from simple heat treatment in dilute systems to the combination of heat and mechanical treatments in concentrated protein solutions, have been used to obtain protein particles

  14. Design and validation of inert homemade explosive simulants for ground penetrating radar

    Science.gov (United States)

    VanderGaast, Brian W.; McFee, John E.; Russell, Kevin L.; Faust, Anthony A.

    2015-05-01

    The Canadian Armed Forces (CAF) identified a requirement for inert simulants to act as improvised, or homemade, explosives (IEs) when training on, or evaluating, ground penetrating radar (GPR) systems commonly used in the detection of buried landmines and improvised explosive devices (IEDs). In response, Defence R and D Canada (DRDC) initiated a project to develop IE simulant formulations using commonly available inert materials. These simulants are intended to approximate the expected GPR response of common ammonium nitrate-based IEs, in particular ammonium nitrate/fuel oil (ANFO) and ammonium nitrate/aluminum (ANAl). The complex permittivity over the range of electromagnetic frequencies relevant to standard GPR systems was measured for bulk quantities of these three IEs that had been fabricated at DRDC Suffield Research Centre. Following these measurements, published literature was examined to find benign materials with both a similar complex permittivity, as well as other physical properties deemed desirable - such as low-toxicity, thermal stability, and commercial availability - in order to select candidates for subsequent simulant formulation. Suitable simulant formulations were identified for ANFO, with resulting complex permittivities measured to be within acceptable limits of target values. These IE formulations will now undergo end-user trials with CAF operators in order to confirm their utility. Investigations into ANAl simulants continues. This progress report outlines the development program, simulant design, and current validation results.

  15. Psychometric Properties and Validation of the Arabic Social Media Addiction Scale

    OpenAIRE

    Al-Menayes, Jamal

    2015-01-01

    This study investigated the psychometric properties of the Arabic version of the SMAS. SMAS is a variant of IAT customized to measure addiction to social media instead of the Internet as a whole. Using a self-report instrument on a cross-sectional sample of undergraduate students, the results revealed the following. First, the exploratory factor analysis showed that a three-factor model fits the data well. Second, concurrent validity analysis showed the SMAS to be a valid measure of social me...

  16. Design and Implementation Content Validity Study: Development of an instrument for measuring Patient-Centered Communication

    Directory of Open Access Journals (Sweden)

    Vahid Zamanzadeh

    2015-06-01

    Full Text Available ABSTRACT Introduction: The importance of content validity in the instrument psychometric and its relevance with reliability, have made it an essential step in the instrument development. This article attempts to give an overview of the content validity process and to explain the complexity of this process by introducing an example. Methods: We carried out a methodological study conducted to examine the content validity of the patient-centered communication instrument through a two-step process (development and judgment. At the first step, domain determination, sampling (item generation and instrument formation and at the second step, content validity ratio, content validity index and modified kappa statistic was performed. Suggestions of expert panel and item impact scores are used to examine the instrument face validity. Results: From a set of 188 items, content validity process identified seven dimensions includes trust building (eight items, informational support (seven items, emotional support (five items, problem solving (seven items, patient activation (10 items, intimacy/friendship (six items and spirituality strengthening (14 items. Content validity study revealed that this instrument enjoys an appropriate level of content validity. The overall content validity index of the instrument using universal agreement approach was low; however, it can be advocated with respect to the high number of content experts that makes consensus difficult and high value of the S-CVI with the average approach, which was equal to 0.93. Conclusion: This article illustrates acceptable quantities indices for content validity a new instrument and outlines them during design and psychometrics of patient-centered communication measuring instrument.

  17. A Simulation Study of Threats to Validity in Quasi-Experimental Designs: Interrelationship between Design, Measurement, and Analysis.

    Science.gov (United States)

    Holgado-Tello, Fco P; Chacón-Moscoso, Salvador; Sanduvete-Chaves, Susana; Pérez-Gil, José A

    2016-01-01

    The Campbellian tradition provides a conceptual framework to assess threats to validity. On the other hand, different models of causal analysis have been developed to control estimation biases in different research designs. However, the link between design features, measurement issues, and concrete impact estimation analyses is weak. In order to provide an empirical solution to this problem, we use Structural Equation Modeling (SEM) as a first approximation to operationalize the analytical implications of threats to validity in quasi-experimental designs. Based on the analogies established between the Classical Test Theory (CTT) and causal analysis, we describe an empirical study based on SEM in which range restriction and statistical power have been simulated in two different models: (1) A multistate model in the control condition (pre-test); and (2) A single-trait-multistate model in the control condition (post-test), adding a new mediator latent exogenous (independent) variable that represents a threat to validity. Results show, empirically, how the differences between both the models could be partially or totally attributed to these threats. Therefore, SEM provides a useful tool to analyze the influence of potential threats to validity.

  18. Psychometric Properties and Validation of the Arabic Social Media Addiction Scale.

    Science.gov (United States)

    Al-Menayes, Jamal

    2015-01-01

    This study investigated the psychometric properties of the Arabic version of the SMAS. SMAS is a variant of IAT customized to measure addiction to social media instead of the Internet as a whole. Using a self-report instrument on a cross-sectional sample of undergraduate students, the results revealed the following. First, the exploratory factor analysis showed that a three-factor model fits the data well. Second, concurrent validity analysis showed the SMAS to be a valid measure of social media addiction. However, further studies and data should verify the hypothesized model. Finally, this study showed that the Arabic version of the SMAS is a valid and reliable instrument for use in measuring social media addiction in the Arab world.

  19. Psychometric Properties and Validation of the Arabic Social Media Addiction Scale

    Directory of Open Access Journals (Sweden)

    Jamal Al-Menayes

    2015-01-01

    Full Text Available This study investigated the psychometric properties of the Arabic version of the SMAS. SMAS is a variant of IAT customized to measure addiction to social media instead of the Internet as a whole. Using a self-report instrument on a cross-sectional sample of undergraduate students, the results revealed the following. First, the exploratory factor analysis showed that a three-factor model fits the data well. Second, concurrent validity analysis showed the SMAS to be a valid measure of social media addiction. However, further studies and data should verify the hypothesized model. Finally, this study showed that the Arabic version of the SMAS is a valid and reliable instrument for use in measuring social media addiction in the Arab world.

  20. DTU-ESA millimeter-wave validation standard antenna – requirements and design

    DEFF Research Database (Denmark)

    Pivnenko, Sergey; Kim, Oleksiy S.; Breinbjerg, Olav

    2014-01-01

    from a validation campaign is achieved when a dedicated Validation Standard (VAST) antenna specifically designed for this purpose is available. The driving requirements to VAST antennas are their mechanical stability with respect to any orientation of the antenna in the gravity field and thermal...... are briefly reviewed and the baseline design is described. The emphasis is given to definition of the requirements for the mechanical and thermal stability of the antenna, which satisfy the stringent stability requirement for the mm-VAST electrical characteristics....

  1. Virtual materials design using databases of calculated materials properties

    International Nuclear Information System (INIS)

    Munter, T R; Landis, D D; Abild-Pedersen, F; Jones, G; Wang, S; Bligaard, T

    2009-01-01

    Materials design is most commonly carried out by experimental trial and error techniques. Current trends indicate that the increased complexity of newly developed materials, the exponential growth of the available computational power, and the constantly improving algorithms for solving the electronic structure problem, will continue to increase the relative importance of computational methods in the design of new materials. One possibility for utilizing electronic structure theory in the design of new materials is to create large databases of materials properties, and subsequently screen these for new potential candidates satisfying given design criteria. We utilize a database of more than 81 000 electronic structure calculations. This alloy database is combined with other published materials properties to form the foundation of a virtual materials design framework (VMDF). The VMDF offers a flexible collection of materials databases, filters, analysis tools and visualization methods, which are particularly useful in the design of new functional materials and surface structures. The applicability of the VMDF is illustrated by two examples. One is the determination of the Pareto-optimal set of binary alloy methanation catalysts with respect to catalytic activity and alloy stability; the other is the search for new alloy mercury absorbers.

  2. Designing and Determining Psychometric Properties of the Domestic Elder Abuse Questionnaire

    Directory of Open Access Journals (Sweden)

    Majid Heravi-Karimooi

    2010-04-01

    Full Text Available Objectives: The purpose of this methodological study was to design and determine the psychometric properties of a new and specific questionnaire for assessing domestic elder abuse in the context of Iranian culture. Methods & Materials: This study was conducted in three phases. In the first phase, phenomenology was applied to explore the meaning of domestic elder abuse phenomenon. In the second phase, a questionnaire was compiled, using the results of the qualitative research implemented in the first phase, in conjunction with the inductions from the expert panel. In the third phase, the psychometric properties including face validity, content validity, construct validity, internal consistency, and test- retest reliability were measured. 325 elderly people who were selected randomly participated in the last stage. Results: The initial 78 item questionnaire designed using the results of first and second phases of study, reduced to 49 items in the process of determining the face and content validity. The result of exploratory factor analysis showed that this questionnaire contains 8 factors including care neglect, psychological abuse, physical abuse, financial abuse, curtailment of personal autonomy, abandonment, financial neglect and emotional neglect. These 8 factors explained nearly 79.93% of the variance. The results of known groups' comparisons showed that this questionnaire could successfully discriminate between subgroups of elderly people in the indexes of re-hospitalization and functional status. The internal consistency (Cronbach’s alpha was 0.90–0.975. Test-retest reliability (ICC of the questionnaire with interval time of two weeks was 0.98 (P<0.001. Conclusion: We concluded that the Domestic Elder Abuse questionnaire with 49 items appears to be a promising tool, providing reliable and valid data helping to detect abuse among elders in different settings such as clinical settings, homes and research environments by health care

  3. An extended protocol for usability validation of medical devices: Research design and reference model.

    Science.gov (United States)

    Schmettow, Martin; Schnittker, Raphaela; Schraagen, Jan Maarten

    2017-05-01

    This paper proposes and demonstrates an extended protocol for usability validation testing of medical devices. A review of currently used methods for the usability evaluation of medical devices revealed two main shortcomings. Firstly, the lack of methods to closely trace the interaction sequences and derive performance measures. Secondly, a prevailing focus on cross-sectional validation studies, ignoring the issues of learnability and training. The U.S. Federal Drug and Food Administration's recent proposal for a validation testing protocol for medical devices is then extended to address these shortcomings: (1) a novel process measure 'normative path deviations' is introduced that is useful for both quantitative and qualitative usability studies and (2) a longitudinal, completely within-subject study design is presented that assesses learnability, training effects and allows analysis of diversity of users. A reference regression model is introduced to analyze data from this and similar studies, drawing upon generalized linear mixed-effects models and a Bayesian estimation approach. The extended protocol is implemented and demonstrated in a study comparing a novel syringe infusion pump prototype to an existing design with a sample of 25 healthcare professionals. Strong performance differences between designs were observed with a variety of usability measures, as well as varying training-on-the-job effects. We discuss our findings with regard to validation testing guidelines, reflect on the extensions and discuss the perspectives they add to the validation process. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Visual Servoing Tracking Control of a Ball and Plate System: Design, Implementation and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Ming-Tzu Ho

    2013-07-01

    Full Text Available This paper presents the design, implementation and validation of real-time visual servoing tracking control for a ball and plate system. The position of the ball is measured with a machine vision system. The image processing algorithms of the machine vision system are pipelined and implemented on a field programmable gate array (FPGA device to meet real-time constraints. A detailed dynamic model of the system is derived for the simulation study. By neglecting the high-order coupling terms, the ball and plate system model is simplified into two decoupled ball and beam systems, and an approximate input-output feedback linearization approach is then used to design the controller for trajectory tracking. The designed control law is implemented on a digital signal processor (DSP. The validity of the performance of the developed control system is investigated through simulation and experimental studies. Experimental results show that the designed system functions well with reasonable agreement with simulations.

  5. Analysis/design of tensile property database system

    International Nuclear Information System (INIS)

    Park, S. J.; Kim, D. H.; Jeon, I.; Lyu, W. S.

    2001-01-01

    The data base construction using the data produced from tensile experiment can increase the application of test results. Also, we can get the basic data ease from database when we prepare the new experiment and can produce high quality result by compare the previous data. The development part must be analysis and design more specific to construct the database and after that, we can offer the best quality to customers various requirements. In this thesis, the analysis and design was performed to develop the database for tensile extension property

  6. Design properties of hydrogel tissue-engineering scaffolds

    Science.gov (United States)

    Zhu, Junmin; Marchant, Roger E

    2011-01-01

    This article summarizes the recent progress in the design and synthesis of hydrogels as tissue-engineering scaffolds. Hydrogels are attractive scaffolding materials owing to their highly swollen network structure, ability to encapsulate cells and bioactive molecules, and efficient mass transfer. Various polymers, including natural, synthetic and natural/synthetic hybrid polymers, have been used to make hydrogels via chemical or physical crosslinking. Recently, bioactive synthetic hydrogels have emerged as promising scaffolds because they can provide molecularly tailored biofunctions and adjustable mechanical properties, as well as an extracellular matrix-like microenvironment for cell growth and tissue formation. This article addresses various strategies that have been explored to design synthetic hydrogels with extracellular matrix-mimetic bioactive properties, such as cell adhesion, proteolytic degradation and growth factor-binding. PMID:22026626

  7. Validation of designing tools as part of nuclear pump development process

    International Nuclear Information System (INIS)

    Klemm, T.; Sehr, F.; Spenner, P.; Fritz, J.

    2010-01-01

    Nuclear pumps are characterized by high safety standards, operational reliability as well as long life cycles. For the design process it is of common use to have a down scaled model pump to qualify operating data and simulate exceptional operating conditions. In case of modifications of the pump design compared to existing reactor coolant pumps a model pump is required to develop methods and tools to design the full scale pump. In the presented case it has a geometry scale of 1:2 regarding the full scale pump size. The experimental data of the model pump is basis for validation of methods and tools which are applied in the designing process of the full scale pump. In this paper the selection of qualified tools and the validation process is demonstrated exemplarily on a cooling circuit. The aim is to predict the resulting flow rate. Tools are chosen for different components depending on the benefit to effort ratio. For elementary flow phenomena such as fluid flow in straight pipes or gaps analytic or empirical laws can be used. For more complex flow situations numerical methods are utilized. Main focus is set on the validation process of the applied numerical flow simulation. In this case not only integral data should be compared, it is also necessary to validate local flow structure of numerical flow simulation to avoid systematic errors in CFD Model generation. Due to complex design internal flow measurements are not possible. On that reason simple comparisons of similar flow test cases are used. Results of this study show, that the flow simulation data closely match measured integral pump and test case data. With this validation it is now possible to qualify CFD simulations as a design tool for the full scale pump in similar cooling circuit. (authors)

  8. Preliminary Axial Flow Turbine Design and Off-Design Performance Analysis Methods for Rotary Wing Aircraft Engines. Part 1; Validation

    Science.gov (United States)

    Chen, Shu-cheng, S.

    2009-01-01

    For the preliminary design and the off-design performance analysis of axial flow turbines, a pair of intermediate level-of-fidelity computer codes, TD2-2 (design; reference 1) and AXOD (off-design; reference 2), are being evaluated for use in turbine design and performance prediction of the modern high performance aircraft engines. TD2-2 employs a streamline curvature method for design, while AXOD approaches the flow analysis with an equal radius-height domain decomposition strategy. Both methods resolve only the flows in the annulus region while modeling the impact introduced by the blade rows. The mathematical formulations and derivations involved in both methods are documented in references 3, 4 for TD2-2) and in reference 5 (for AXOD). The focus of this paper is to discuss the fundamental issues of applicability and compatibility of the two codes as a pair of companion pieces, to perform preliminary design and off-design analysis for modern aircraft engine turbines. Two validation cases for the design and the off-design prediction using TD2-2 and AXOD conducted on two existing high efficiency turbines, developed and tested in the NASA/GE Energy Efficient Engine (GE-E3) Program, the High Pressure Turbine (HPT; two stages, air cooled) and the Low Pressure Turbine (LPT; five stages, un-cooled), are provided in support of the analysis and discussion presented in this paper.

  9. Experimental Validation of Topology Optimization for RF MEMS Capacitive Switch Design

    DEFF Research Database (Denmark)

    Philippine, Mandy Axelle; Zareie, Hosein; Sigmund, Ole

    2013-01-01

    In this paper, we present 30 distinct RF MEMS capacitive switch designs that are the product of topology optimizations that control key mechanical properties such as stiffness, response to intrinsic stress gradients, and temperature sensitivity. The designs were evaluated with high-accuracy simul...

  10. Reliability and validity of the rey visual design learning test in primary school children

    NARCIS (Netherlands)

    Wilhelm, P.

    2004-01-01

    The Rey Visual Design Learning Test (Rey, 1964, in Spreen & Strauss, 1991) assesses immediate memory span, new learning and recognition for non-verbal material. Three studies are presented that focused on the reliability and validity of the RVDLT in primary school children. Test-retest reliability

  11. Validity of the rey visual design test in primary and secondary school children

    NARCIS (Netherlands)

    Wilhelm, P.; van Klink, M.; van Klink, M.

    2007-01-01

    The Rey Visual Design Learning Test (Rey, 1964, cited in Spreen & Strauss, 1991, Wilhelm, 2004) assesses immediate memory span, new learning, delayed recall and recognition for nonverbal material. Two studies are presented that focused on the construct validity of the RVDLT in primary and secondary

  12. Design of passive directional acoustic devices using Topology Optimization - from method to experimental validation

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Fernandez Grande, Efren

    2016-01-01

    emission in two dimensions and is experimentally validated using three dimensional prints of the optimized designs. The emitted fields exhibit a level difference of at least 15 dB on axis relative to the off-axis directions, over frequency bands of approximately an octave. It is demonstrated to be possible...

  13. Design, Validation, and Use of an Evaluation Instrument for Monitoring Systemic Reform.

    Science.gov (United States)

    Scantlebury, Kathryn; Boone, William; Kahle, Jane Butler; Fraser, Barry J.

    2001-01-01

    Describes the design, development, validation, and use of an instrument that measures student attitudes and several environmental dimensions (i.e., standards-based teaching, home support, and peer support). Indicates that the classroom environment (standards-based teaching practices) was the strongest independent predictor of both achievement and…

  14. Design and Fabrication of a Soil Moisture Meter Using Thermal Conductivity Properties of Soil

    Directory of Open Access Journals (Sweden)

    Subir DAS

    2011-09-01

    Full Text Available Study of soil for agricultural purposes is one of the main focuses of research since the beginning of civilization as food related requirements is closely linked with the soil. The study of soil has generated an interest among the researchers for very similar other reasons including understanding of soil water dynamics, evolution of agricultural water stress and validation of soil moisture modeling. In this present work design of a soil moisture measurement meter using thermal conductivity properties of soil has been proposed and experimental results are reported.

  15. De novo peptide design and experimental validation of histone methyltransferase inhibitors.

    Directory of Open Access Journals (Sweden)

    James Smadbeck

    Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 mM, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly inhibit EZH2

  16. De novo peptide design and experimental validation of histone methyltransferase inhibitors.

    Directory of Open Access Journals (Sweden)

    James Smadbeck

    Full Text Available Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA-protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2 maintains gene repression over successive cell generations. Overexpression of EZH2 can silence important tumor suppressor genes leading to increased invasiveness of many types of cancers. This makes the inhibition of EZH2 an important target in the development of cancer therapeutics. We employed a three-stage computational de novo peptide design method to design inhibitory peptides of EZH2. The method consists of a sequence selection stage and two validation stages for fold specificity and approximate binding affinity. The sequence selection stage consists of an integer linear optimization model that was solved to produce a rank-ordered list of amino acid sequences with increased stability in the bound peptide-EZH2 structure. These sequences were validated through the calculation of the fold specificity and approximate binding affinity of the designed peptides. Here we report the discovery of novel EZH2 inhibitory peptides using the de novo peptide design method. The computationally discovered peptides were experimentally validated in vitro using dose titrations and mechanism of action enzymatic assays. The peptide with the highest in vitro response, SQ037, was validated in nucleo using quantitative mass spectrometry-based proteomics. This peptide had an IC50 of 13.5 [Formula: see text]M, demonstrated greater potency as an inhibitor when compared to the native and K27A mutant control peptides, and demonstrated competitive inhibition versus the peptide substrate. Additionally, this peptide demonstrated high specificity to the EZH2 target in comparison to other histone methyltransferases. The validated peptides are the first computationally designed peptides that directly

  17. Psychometric Properties and Validation of the Positive and Negative Suicide Ideation (PANSI) Inventory in an Outpatient Clinical Population in Malaysia.

    Science.gov (United States)

    Sinniah, Aishvarya; Oei, Tian P S; Chinna, Karuthan; Shah, Shamsul A; Maniam, T; Subramaniam, Ponnusamy

    2015-01-01

    The PANSI is a measure designed to assess the risk and protective factors related to suicidal behaviors. The present study evaluated the psychometric properties and factor structure of the Positive and Negative Suicide Ideation (PANSI) Inventory in a sample of clinical outpatients at a major hospital in Malaysia. In this study, 283 psychiatric patients and 200 medical (non-psychiatric) patients participated. All the patients completed the PANSI and seven other self-report instruments. Confirmative factor analysis supported the 2-factor oblique model. The internal consistency of the two subscales of PANSI-Negative and the PANSI-Positive were 0.93 and 0.84, respectively. In testing construct validity, PANSI showed sizable correlation with the other seven scales. Criterion validity was supported by scores on PANSI which differentiated psychiatric patients from medical patients. Logistic regression analyses showed PANSI can be used to classify the patients into suicidal or non-suicidal. The PANSI is a reliable and valid instrument to measure the severity of suicidal ideation among clinical outpatients in Malaysia.

  18. PSYCHOMETRIC PROPERTIES AND VALIDATION OF THE POSITIVE AND NEGATIVE SUICIDE IDEATION (PANSI INVENTORY IN AN OUTPATIENT CLINICAL POPULATION IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    Aishvarya eSinniah

    2015-12-01

    Full Text Available The PANSI is a measure designed to assess the risk and protective factors related to suicidal behaviors. The present study evaluated the psychometric properties and factor structure of the Positive and Negative Suicide Ideation (PANSI Inventory in a sample of clinical outpatients at a major hospital in Malaysia. In this study, 283 psychiatric patients and 200 medical (non- psychiatric patients participated. All the patients completed the PANSI and seven other self-report instruments. Confirmative factor analysis supported the 2-factor oblique model. The internal consistency of the two subscales of PANSI-Negative and the PANSI-Positive were 0.93 and 0.84, respectively. In testing construct validity, PANSI showed sizable correlation with the other seven scales. Criterion validity was supported by scores on PANSI which differentiated psychiatric patients from medical patients. Logistic regression analyses showed PANSI can be used to classify the patients into suicidal or non-suicidal. The PANSI is a reliable and valid instrument to measure the severity of suicidal ideation among clinical outpatients in Malaysia.

  19. Tribological properties of nanostripe surface structures-a design concept for improving tribological properties

    International Nuclear Information System (INIS)

    Miyake, K; Nakano, M; Korenaga, A; Mano, H; Ando, Y

    2010-01-01

    The tribological properties of nanostripe surface structures were investigated using a pin-on-plate tribometer in order to propose a design concept for improving the tribological properties. The authors used four kinds of nanostripe structures consisting of different combinations of materials (Fe-Au, C-SiC, Al-Al 2 O 3 and Al-Pt) fabricated by a process they had previously proposed. The frictional properties of the nanostripe structures depended on the materials that constituted the nanostripes. When the sliding direction in friction tests was parallel to the microgrooves, nanostripe structures remained on all surfaces even after friction tests. Based on the friction test results, the authors considered a design concept for nanostripe structures in tribological applications.

  20. Process design of press hardening with gradient material property influence

    International Nuclear Information System (INIS)

    Neugebauer, R.; Schieck, F.; Rautenstrauch, A.

    2011-01-01

    Press hardening is currently used in the production of automotive structures that require very high strength and controlled deformation during crash tests. Press hardening can achieve significant reductions of sheet thickness at constant strength and is therefore a promising technology for the production of lightweight and energy-efficient automobiles. The manganese-boron steel 22MnB5 have been implemented in sheet press hardening owing to their excellent hot formability, high hardenability, and good temperability even at low cooling rates. However, press-hardened components have shown poor ductility and cracking at relatively small strains. A possible solution to this problem is a selective increase of steel sheet ductility by press hardening process design in areas where the component is required to deform plastically during crash tests. To this end, process designers require information about microstructure and mechanical properties as a function of the wide spectrum of cooling rates and sequences and austenitizing treatment conditions that can be encountered in production environments. In the present work, a Continuous Cooling Transformation (CCT) diagram with corresponding material properties of sheet steel 22MnB5 was determined for a wide spectrum of cooling rates. Heating and cooling programs were conducted in a quenching dilatometer. Motivated by the importance of residual elasticity in crash test performance, this property was measured using a micro-bending test and the results were integrated into the CCT diagrams to complement the hardness testing results. This information is essential for the process design of press hardening of sheet components with gradient material properties.

  1. Heat experiment design to estimate temperature dependent thermal properties

    International Nuclear Information System (INIS)

    Romanovski, M

    2008-01-01

    Experimental conditions are studied to optimize transient experiments for estimating temperature dependent thermal conductivity and volumetric heat capacity. A mathematical model of a specimen is the one-dimensional heat equation with boundary conditions of the second kind. Thermal properties are assumed to vary nonlinearly with temperature. Experimental conditions refer to the thermal loading scheme, sampling times and sensor location. A numerical model of experimental configurations is studied to elicit the optimal conditions. The numerical solution of the design problem is formulated on a regularization scheme with a stabilizer minimization without a regularization parameter. An explicit design criterion is used to reveal the optimal sensor location, heating duration and flux magnitude. Results obtained indicate that even the strongly nonlinear experimental design problem admits the aggregation of its solution and has a strictly defined optimal measurement scheme. Additional region of temperature measurements with allowable identification error is revealed.

  2. [Design and Validation of a Questionnaire on Vaccination in Students of Health Sciences, Spain].

    Science.gov (United States)

    Fernández-Prada, María; Ramos-Martín, Pedro; Madroñal-Menéndez, Jaime; Martínez-Ortega, Carmen; González-Cabrera, Joaquín

    2016-11-07

    Immunization rates among medicine and nursing students -and among health professional in general- during hospital training are low. It is necessary to investigate the causes for these low immunization rates. The objective of this study was to design and validate a questionnaire for exploring the attitudes and behaviours of medicine and nursing students toward immunization of vaccine-preventable diseases. An instrument validation study. The sample included 646 nursing and medicine students at University of Oviedo, Spain. It was a non-ramdom sampling. After the content validation process, a 24-item questionnaire was designed to assess attitudes and behaviours/behavioural intentions. Reliability (ordinal alpha), internal validity (exploratory factor analysis by parellel analysis), ANOVA and mediational model tests were performed. Exploratory factor analysis yielded two factors which accounted for 48.8% of total variance. Ordinal alpha for the total score was 0.92. Differences were observed across academic years in the dimensions of attitudes (F5.447=3.728) and knowledge (F5.448=65.59), but not in behaviours/behavioural intentions (F5.461=1.680). Attitudes demonstrated to be a moderating variable of knowledge and attitudes/behavioural attitudes (Indirect effect B=0.15; SD=0.3; 95% CI:0.09-0.19). We developed a questionnaie based on sufficient evidence of reliability and internal validity. Scores on attitudes and knowledge increase with the academic year. Attitudes act as a moderating variable between knowledge and behaviours/behavioural intentions.

  3. Validity and Psychometric Properties of Malay Translated Religious Orientation Scale-Revised among Malaysian Adult Samples

    Directory of Open Access Journals (Sweden)

    Mohammad Rahim Kamaluddin

    2017-08-01

    Full Text Available Religious Orientation Scale-Revised (ROS-R has been used increasingly as an important measure in psychology of religion based researches and widely administered in cross-cultural settings. Unfortunately, there is no valid and reliable ROS-R available in Malay language to assess religious orientations among Malaysians. With that in mind, the present study aims to validate and document the psychometric properties of Malay translated ROS-R (henceforth, M-ROS-R among sample of Malaysian adults. This study commenced with Forward-Backward translations and was followed by content and face validities. Subsequently, a cross-sectional study was conducted among Malaysian adults (n = 226 using convenience sampling method for the purpose of construct and factorial validations. Later, construct and factorial validity was performed via Exploratory Factor Analysis using Principal Component Analysis with Varimax rotation. Finally, reliability testing was performed to determine the internal consistency of the items which was achieved using Cronbach’s Alpha coefficient method (α. The factor loading consisted of three factors with a total variance of 64.76%. The final version of M-ROS-R consisted of 14 items with Factor 1 (Intrinsic Orientation comprised of 8 items, Factor 2 (Extrinsic-Socially Orientated with 3 items while Factor 3 (Extrinsic-Personally Orientated constituted 3 items. The internal consistency values of the factors ranged between 0.68 and 0.86, indicating the scale is reliable. The intercorrelations between factors were also significant with each other. M-ROS-R was concluded as a valid and reliable scale to measure and assess religious orientations among Malaysians.

  4. Human factors engineering and design validation for the redesigned follitropin alfa pen injection device.

    Science.gov (United States)

    Mahony, Mary C; Patterson, Patricia; Hayward, Brooke; North, Robert; Green, Dawne

    2015-05-01

    To demonstrate, using human factors engineering (HFE), that a redesigned, pre-filled, ready-to-use, pre-asembled follitropin alfa pen can be used to administer prescribed follitropin alfa doses safely and accurately. A failure modes and effects analysis identified hazards and harms potentially caused by use errors; risk-control measures were implemented to ensure acceptable device use risk management. Participants were women with infertility, their significant others, and fertility nurse (FN) professionals. Preliminary testing included 'Instructions for Use' (IFU) and pre-validation studies. Validation studies used simulated injections in a representative use environment; participants received prior training on pen use. User performance in preliminary testing led to IFU revisions and a change to outer needle cap design to mitigate needle stick potential. In the first validation study (49 users, 343 simulated injections), in the FN group, one observed critical use error resulted in a device design modification and another in an IFU change. A second validation study tested the mitigation strategies; previously reported use errors were not repeated. Through an iterative process involving a series of studies, modifications were made to the pen design and IFU. Simulated-use testing demonstrated that the redesigned pen can be used to administer follitropin alfa effectively and safely.

  5. Validation of a fracture mechanics approach to nuclear transportation cask design through a drop test program

    International Nuclear Information System (INIS)

    Sorenson, K.B.

    1986-01-01

    Sandia National Laboratories (SNL), under contract to the Department of Energy, is conducting a research program to develop and validate a fracture mechanics approach to cask design. A series of drop tests of a transportation cask is planned for the summer of 1986 as the method for benchmarking and, thereby, validating the fracture mechanics approach. This paper presents the drop test plan and background leading to the development of the test plan including structural analyses, material characterization, and non-destructive evaluation (NDE) techniques necessary for defining the test plan properly

  6. Effects of pore design on mechanical properties of nanoporous silicon

    International Nuclear Information System (INIS)

    Winter, Nicholas; Becton, Matthew; Zhang, Liuyang; Wang, Xianqiao

    2017-01-01

    Nanoporous silicon has been emerging as a powerful building block for next-generation sensors, catalysts, transistors, and tissue scaffolds. The capability to design novel devices with desired mechanical properties is paramount to their reliability and serviceability. In order to bring further resolution to the highly variable mechanical characteristics of nanoporous silicon, here we perform molecular dynamics simulations to study the effects of ligament thickness, relative density, and pore geometry/orientation on the mechanical properties of nanoporous silicon, thereby determining its Young's modulus, ultimate strength, and toughness as well as the scaling laws versus the features of interior ligaments. Results show that pore shape and pattern dictate stress accumulation inside the designed structure, leading to the corresponding failure signature, such as stretching-dominated, bending-dominated, or stochastic failure signatures, in nanoporous silicon. The nanostructure of the material is also seen to drive or mute size effects such as “smaller is stronger” and “smaller is ductile”. This investigation provides useful insight into the behavior of nanoporous silicon and how one might leverage its promising applications. - Graphical abstract: Molecular dynamics simulations are performed to study the effects of ligament thickness, relative density, and pore geometry/orientation on the mechanical properties of nanoporous silicon, thereby determining its Young's modulus, ultimate strength, and toughness as well as the scaling trends versus the features of interior ligaments.

  7. Design and Evaluation of the Psychometric Properties of a Paternal Adaptation Questionnaire.

    Science.gov (United States)

    Eskandari, Narges; Simbar, Masoumeh; Vadadhir, AbouAli; Baghestani, Ahmad Reza

    2016-07-25

    The present study aimed to design and evaluate the psychometric properties of the Paternal Adaptation Questionnaire (PAQ). The study was a mixed (qualitative and quantitative) sequential exploratory study. In the qualitative phase, a preliminary questionnaire with 210 items emerged from in-depth interviews with 17 fathers and 15 key informants. In the quantitative phase, psychometric properties of the PAQ were assessed. Considering cutoff points as 1.5 for item impact, 0.49 for content validity ratio (CVR), and 0.7 for content validity index (CVI), items of the questionnaire were reduced from 210 to 132. Assessment of the content validity of the questionnaire demonstrated S-CVR = 0.68 and S-CVI = 0.92. Exploratory factor analysis resulted in the development of a PAQ with 38 items classified under five factors (ability in performing the roles and responsibilities; perceiving the parental development; stabilization in paternal position; spiritual stability and internal satisfaction; and challenges and concerns), which explained 52.19% of cumulative variance. Measurement of internal consistency reported a Cronbach's α of .89 for PAQ (.61-.86 for subscales), and stability assessment of the PAQ through the test-retest demonstrated Spearman's correlation coefficients and intraclass correlation coefficient of .96 (.81-.97 for subscales). It was identified that the PAQ is a valid and reliable instrument that could be used to assess fatherhood adaptation with the paternal roles and fathers' needs, as well as to design appropriate interventions and to evaluate their effectiveness. © The Author(s) 2016.

  8. Using a 2D detector array for meaningful and efficient linear accelerator beam property validations.

    Science.gov (United States)

    Ritter, Timothy A; Gallagher, Ian; Roberson, Peter L

    2014-11-08

    Following linear accelerator commissioning, the qualified medical physicist is responsible for monitoring the machine's ongoing performance, detecting and investigating any changes in beam properties, and assessing the impact of unscheduled repairs. In support of these responsibilities, the authors developed a method of using a 2D ionization chamber array to efficiently test and validate important linear accelerator photon beam properties. A team of three physicists identified critical properties of the accelerator and developed constancy tests that were sensitive to each of the properties. The result was a 14-field test plan. The test plan includes large and small fields at varying depths, a reduced SSD field at shallow depth for sensitivity to extra focal photon and electron components, and analysis of flatness, symmetry, dose, dose profiles, and dose ratios. Constancy tests were repeated five times over a period of six weeks and used to set upper and lower investigation levels at ± 3 SDs. Deliberate variations in output, penumbra, and energy were tested to determine the suitability of the proposed method. Measurements were also performed on a similar, but distinct, machine to assess test sensitivity. The results demonstrated upper and lower investigation levels significantly smaller than the comparable TG-142 annual recommendations, with the exception of the surrogate used for output calibration, which still fell within the TG-142 monthly recommendation. Subtle changes in output, beam energy, and penumbra were swiftly identified for further investigation. The test set identified the distinct nature of the second accelerator. The beam properties of two photon energies can be validated in approximately 1.5 hrs using this method. The test suite can be used to evaluate the impact of minor repairs, detect changes in machine performance over time, and supplement other machine quality assurance testing.

  9. Validation of Karolinska Exhaustion Scale: psychometric properties of a measure of exhaustion syndrome.

    Science.gov (United States)

    Saboonchi, Fredrik; Perski, Aleksander; Grossi, Giorgio

    2013-12-01

    The syndrome of exhaustion is currently a medical diagnosis in Sweden. The description of the syndrome largely corresponds to the suggested core component of burnout, that is exhaustion. Karolinska Exhaustion Scale (KES) has been constructed to provide specific assessment of exhaustion in clinical and research settings. The purpose of the present study was to examine the psychometric properties of this scale in its original and revised versions by examining the factorial structure and measures of convergent and discriminant validity. Data gathered from two independent samples (n1 = 358 & n2 = 403) consisting of patients diagnosed with 'reaction to severe stress, and adjustment disorder' were subjected to confirmatory factor analysis. The study's instruments were Karolinska Exhaustion Scale and Shirom Melam Burnout Measure. Correlation analyses were employed to follow up the established factorial structure of the scale. The study was ethically approved by Karolinska Institute regional ethic committee. The findings demonstrated adequate fit of the data to the measurement model provided by the revised version of KES Limitations: The main limitation of the present study is the lack of a gold standard of exhaustion for direct comparison with KES. (KES-26) and partially supported convergent validity and discriminant validity of the scale. The demonstrated psychometric properties of KES-26 indicate sound construct validity for this scale encouraging use of this scale in assessment of exhaustion. The factorial structure of KES-26 may also be used to provide information concerning possible different clinical profiles. © 2012 The Authors Scandinavian Journal of Caring Sciences © 2012 Nordic College of Caring Science.

  10. Reliability, validity and psychometric properties of the Greek translation of the Major Depression Inventory

    Directory of Open Access Journals (Sweden)

    Tsiptsios I

    2003-01-01

    Full Text Available Abstract Background The Major Depression Inventory (MDI is a brief self-rating scale for the assessment of depression. It is reported to be valid because it is based on the universe of symptoms of DSM-IV and ICD-10 depression. The aim of the current preliminary study was to assess the reliability, validity and psychometric properties of the Greek translation of the MDI. Methods 30 depressed patients of mean age 23.41 (± 5.77 years, and 68 controls patients of mean age 25.08 (± 11.42 years, entered the study. In 18 of them, the instrument was re-applied 1–2 days later and the Translation and Back Translation made. Clinical diagnosis was reached with the use of the SCAN v.2.0 and the International Personality Disorders Examination (IPDE. The Center for Epidemiological Studies-Depression (CES-D and the Zung Depression Rating Scale (ZDRS were applied for cross-validation purposes. Statistical analysis included ANOVA, the Spearman Product Moment Correlation Coefficient, Principal Components Analysis and the calculation of Cronbach's α. Results Sensitivity and specificity were 0.86 and 0.94, respectively, at 26/27. Cronbach's α for the total scale was equal to 0.89. The Spearman's rho between MDI and CES-D was 0.86 and between MDI and ZDRS was 0.76. The factor analysis revealed two factors but the first accounted for 54% of variance while the second only for 9%. The test-retest reliability was excellent (Spearman's rho between 0.53 and 0.96 for individual items and 0.89 for total score. Conclusion The current study provided preliminary evidence concerning the reliability and validity of the Greek translation of the MDI. Its properties are similar to those reported in the international literature, but further research is necessary.

  11. Systematic methodology and property prediction of fatty systems for process design/analysis in the oil and fat industry

    DEFF Research Database (Denmark)

    Díaz Tovar, Carlos Axel; Ceriani, Roberta; Gani, Rafiqul

    2010-01-01

    in the vegetable oil were defined. Basic and critical properties were then computed by means of appropriate property prediction software. Temperature dependant properties were modeled using and extending available correlations. The process model was developed through the PRO II commercial simulator and validated......A systematic model based methodology has been developed and its application highlighted through the solvent recovery section of a soybean oil extraction process, with emphasis on the effect of design variables on the process performance. First, the most representative compounds present...

  12. Sexual Self-Schema Scale for Women—Validation and Psychometric Properties of the Polish Version

    Directory of Open Access Journals (Sweden)

    Krzysztof Nowosielski, MD

    2018-06-01

    Full Text Available Introduction: The sexual self-schema is a part of a broader concept of the self that is believed to be crucial for intrapersonal and interpersonal sexual relationships. Aim: To develop and perform psychometric validation of the Polish version of the Sexual Self-Schema Scale for Women (SSSS-W-PL. Methods: 561 women 18 to 55 years old were included in the final analysis. Linguistic validation was performed in 4 steps in line with the MAPI Institute guidelines. Convergent validity was calculated using the Pearson r product-moment coefficient between different measures of sexuality (attitudes and experience, behavior, arousal, romantic relationship and SSSS-W-PL total and factor scores. To test discriminant validity, we applied hierarchical regression analyses predicting the number of lifetime sexual partners, self-rating as a sexual person (1 item, “I feel sexually attractive”; on a 5-point Likert scale, and arousability, with independent variables being extraversion (Ten-Item Personality Inventory, self-esteem (Rosenberg Self-Esteem Scale, and the SSSS-W-PL (total and factor scores. Main Outcomes Measures: Sexual self-schema was measured by the SSSS-W-PL, whereas arousability was measured by the arousal/excitement scale of the Changes in Sexual Functioning Questionnaire. Results: The mean age of the study population was 29.0 ± 7.6 years. The final scale consisted of 24 adjectives grouped within 4 factors: romantic, passionate, direct, and embarrassed. The 4-factor model accounted for 39% of the variance. The Cronbach α was 0.74 for the SSSS-W-PL total score and 0.61 to 0.84 for individual factors. Test-retest reliability of the scale after 2- to 8-week intervals was 0.87 (95% CI = 0.82–0.86, P < .001. The increment variances were statistically significant and ranged from 3.8% to 11.6%. Conclusion: The analysis showed good psychometric properties and internal validity of the SSSS-W-PL. The SSSS-W-PL might be helpful in consulting and

  13. Verification and validation of human factors issues in control room design and upgrades

    Energy Technology Data Exchange (ETDEWEB)

    Green, M.; Collier, S. [Inst. for Energiteknikk, Halden (Norway). OECD Halden Reactor Project

    1999-12-01

    Systems, facilities and equipment are periodically updated during a power plant's lifetime. This has human factors implications, especially if the central control room is involved. Human factors work may therefore be required. There is an extensive literature on human factors itself, but not so much on how it is verified and validated. Therefore, HRP and the Swedish Nuclear Power Inspectorate commissioned a study. The objective was to review the literature and establish a knowledge base on verification and validation (V and V) of human factors issues. The report first discusses verification and validation as applied to human factors work. It describes a design process and the typical human factors topics involved. It then presents a generic method for V and V of human factors. This is built on a review of standards, guidelines and other references given in an annotated bibliography. The method is illustrated by application to some human factors topics.

  14. Verification and validation of human factors issues in control room design and upgrades

    International Nuclear Information System (INIS)

    Green, M.; Collier, S.

    1999-12-01

    Systems, facilities and equipment are periodically updated during a power plant's lifetime. This has human factors implications, especially if the central control room is involved. Human factors work may therefore be required. There is an extensive literature on human factors itself, but not so much on how it is verified and validated. Therefore, HRP and the Swedish Nuclear Power Inspectorate commissioned a study. The objective was to review the literature and establish a knowledge base on verification and validation (V and V) of human factors issues. The report first discusses verification and validation as applied to human factors work. It describes a design process and the typical human factors topics involved. It then presents a generic method for V and V of human factors. This is built on a review of standards, guidelines and other references given in an annotated bibliography. The method is illustrated by application to some human factors topics

  15. Sexual Self-Schema Scale for Women-Validation and Psychometric Properties of the Polish Version.

    Science.gov (United States)

    Nowosielski, Krzysztof; Jankowski, Konrad S; Kowalczyk, Robert; Kurpisz, Jacek; Normantowicz-Zakrzewska, Małgorzata; Krasowska, Aleksandra

    2018-06-01

    The sexual self-schema is a part of a broader concept of the self that is believed to be crucial for intrapersonal and interpersonal sexual relationships. To develop and perform psychometric validation of the Polish version of the Sexual Self-Schema Scale for Women (SSSS-W-PL). 561 women 18 to 55 years old were included in the final analysis. Linguistic validation was performed in 4 steps in line with the MAPI Institute guidelines. Convergent validity was calculated using the Pearson r product-moment coefficient between different measures of sexuality (attitudes and experience, behavior, arousal, romantic relationship) and SSSS-W-PL total and factor scores. To test discriminant validity, we applied hierarchical regression analyses predicting the number of lifetime sexual partners, self-rating as a sexual person (1 item, "I feel sexually attractive"; on a 5-point Likert scale), and arousability, with independent variables being extraversion (Ten-Item Personality Inventory), self-esteem (Rosenberg Self-Esteem Scale), and the SSSS-W-PL (total and factor scores). Sexual self-schema was measured by the SSSS-W-PL, whereas arousability was measured by the arousal/excitement scale of the Changes in Sexual Functioning Questionnaire. The mean age of the study population was 29.0 ± 7.6 years. The final scale consisted of 24 adjectives grouped within 4 factors: romantic, passionate, direct, and embarrassed. The 4-factor model accounted for 39% of the variance. The Cronbach α was 0.74 for the SSSS-W-PL total score and 0.61 to 0.84 for individual factors. Test-retest reliability of the scale after 2- to 8-week intervals was 0.87 (95% CI = 0.82-0.86, P Self-Schema Scale for Women-Validation and Psychometric Properties of the Polish Version. Sex Med 2018;6:131-142. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  16. Design of materials configurations for enhanced phononic and electronic properties

    Science.gov (United States)

    Daraio, Chiara

    The discovery of novel nonlinear dynamic and electronic phenomena is presented for the specific cases of granular materials and carbon nanotubes. This research was conducted for designing and constructing optimized macro-, micro- and nano-scale structural configurations of materials, and for studying their phononic and electronic behavior. Variation of composite arrangements of granular elements with different elastic properties in a linear chain-of-sphere, Y-junction or 3-D configurations led to a variety of novel phononic phenomena and interesting physical properties, which can be potentially useful for security, communications, mechanical and biomedical engineering applications. Mechanical and electronic properties of carbon nanotubes with different atomic arrangements and microstructures were also investigated. Electronic properties of Y-junction configured carbon nanotubes exhibit an exciting transistor switch behavior which is not seen in linear configuration nanotubes. Strongly nonlinear materials were designed and fabricated using novel and innovative concepts. Due to their unique strongly nonlinear and anisotropic nature, novel wave phenomena have been discovered. Specifically, violations of Snell's law were detected and a new mechanism of wave interaction with interfaces between NTPCs (Nonlinear Tunable Phononic Crystals) was established. Polymer-based systems were tested for the first time, and the tunability of the solitary waves speed was demonstrated. New materials with transformed signal propagation speed in the manageable range of 10-100 m/s and signal amplitude typical for audible speech have been developed. The enhancing of the mitigation of solitary and shock waves in 1-D chains were demonstrated and a new protective medium was designed for practical applications. 1-D, 2-D and 3-D strongly nonlinear system have been investigated providing a broad impact on the whole area of strongly nonlinear wave dynamics and creating experimental basis for new

  17. Design and validation of an observational instrument for technical and tactical actions in beach volleyball

    Directory of Open Access Journals (Sweden)

    José Manuel Palao

    2015-06-01

    Full Text Available Technical and tactical actions determine performance in beach volleyball. This research develops and tests an instrument to monitor and evaluate the manner of execution and efficacy of the actions in beach volleyball. The purpose of this paper was to design and validate an observational instrument to analyze technical and tactical actions in beach volleyball. The instrument collects information regarding: a information about the match (context, b information about game situations, c information about technical situations (serve, reception, set, attack, block, and court defense in relation to player execution, role, manner of execution, execution zone, and efficacy, and d information about the result of the play (win-lose and way point is obtained. Instrument design and validation was done in seven stages: a review of literature and consultation of experts; b pilot observation and data analysis; c expert review of instrument (qualitative and quantitative evaluation; d observer training test; e expert review of instrument (content validity; f measurement of the ability of the instrument to discriminate the result of the set; and g measurement of the ability of the instrument to differentiate between competition age groups. The results show that the instrument allows for obtaining objective and valid information about the players and team from offensive and defensive technical and tactical actions, as well as indirectly from physical actions. The instrument can be used, in its entirety or partially, for researching and coaching purposes.

  18. Design and validation of Segment - freely available software for cardiovascular image analysis

    International Nuclear Information System (INIS)

    Heiberg, Einar; Sjögren, Jane; Ugander, Martin; Carlsson, Marcus; Engblom, Henrik; Arheden, Håkan

    2010-01-01

    Commercially available software for cardiovascular image analysis often has limited functionality and frequently lacks the careful validation that is required for clinical studies. We have already implemented a cardiovascular image analysis software package and released it as freeware for the research community. However, it was distributed as a stand-alone application and other researchers could not extend it by writing their own custom image analysis algorithms. We believe that the work required to make a clinically applicable prototype can be reduced by making the software extensible, so that researchers can develop their own modules or improvements. Such an initiative might then serve as a bridge between image analysis research and cardiovascular research. The aim of this article is therefore to present the design and validation of a cardiovascular image analysis software package (Segment) and to announce its release in a source code format. Segment can be used for image analysis in magnetic resonance imaging (MRI), computed tomography (CT), single photon emission computed tomography (SPECT) and positron emission tomography (PET). Some of its main features include loading of DICOM images from all major scanner vendors, simultaneous display of multiple image stacks and plane intersections, automated segmentation of the left ventricle, quantification of MRI flow, tools for manual and general object segmentation, quantitative regional wall motion analysis, myocardial viability analysis and image fusion tools. Here we present an overview of the validation results and validation procedures for the functionality of the software. We describe a technique to ensure continued accuracy and validity of the software by implementing and using a test script that tests the functionality of the software and validates the output. The software has been made freely available for research purposes in a source code format on the project home page (http://segment.heiberg.se). Segment

  19. A unified approach to validation, reliability, and education study design for surgical technical skills training.

    Science.gov (United States)

    Sweet, Robert M; Hananel, David; Lawrenz, Frances

    2010-02-01

    To present modern educational psychology theory and apply these concepts to validity and reliability of surgical skills training and assessment. In a series of cross-disciplinary meetings, we applied a unified approach of behavioral science principles and theory to medical technical skills education given the recent advances in the theories in the field of behavioral psychology and statistics. While validation of the individual simulation tools is important, it is only one piece of a multimodal curriculum that in and of itself deserves examination and study. We propose concurrent validation throughout the design of simulation-based curriculum rather than once it is complete. We embrace the concept that validity and curriculum development are interdependent, ongoing processes that are never truly complete. Individual predictive, construct, content, and face validity aspects should not be considered separately but as interdependent and complementary toward an end application. Such an approach could help guide our acceptance and appropriate application of these exciting new training and assessment tools for technical skills training in medicine.

  20. Deployable and Conformal Planar Micro-Devices: Design and Model Validation

    Directory of Open Access Journals (Sweden)

    Jinda Zhuang

    2014-08-01

    Full Text Available We report a design concept for a deployable planar microdevice and the modeling and experimental validation of its mechanical behavior. The device consists of foldable membranes that are suspended between flexible stems and actuated by push-pull wires. Such a deployable device can be introduced into a region of interest in its compact “collapsed” state and then deployed to conformally cover a large two-dimensional surface area for minimally invasive biomedical operations and other engineering applications. We develop and experimentally validate theoretical models based on the energy minimization approach to examine the conformality and figures of merit of the device. The experimental results obtained using model contact surfaces agree well with the prediction and quantitatively highlight the importance of the membrane bending modulus in controlling surface conformality. The present study establishes an early foundation for the mechanical design of this and related deployable planar microdevice concepts.

  1. The Dynamic Similitude Design Method of Thin Walled Structures and Experimental Validation

    Directory of Open Access Journals (Sweden)

    Zhong Luo

    2016-01-01

    Full Text Available For the applicability of dynamic similitude models of thin walled structures, such as engine blades, turbine discs, and cylindrical shells, the dynamic similitude design of typical thin walled structures is investigated. The governing equation of typical thin walled structures is firstly unified, which guides to establishing dynamic scaling laws of typical thin walled structures. Based on the governing equation, geometrically complete scaling law of the typical thin walled structure is derived. In order to determine accurate distorted scaling laws of typical thin walled structures, three principles are proposed and theoretically proved by combining the sensitivity analysis and governing equation. Taking the thin walled annular plate as an example, geometrically complete and distorted scaling laws can be obtained based on the principles of determining dynamic scaling laws. Furthermore, the previous five orders’ accurate distorted scaling laws of thin walled annular plates are presented and numerically validated. Finally, the effectiveness of the similitude design method is validated by experimental annular plates.

  2. Designed cellulose nanocrystal surface properties for improving barrier properties in polylactide nanocomposites.

    Science.gov (United States)

    Espino-Pérez, Etzael; Bras, Julien; Almeida, Giana; Plessis, Cédric; Belgacem, Naceur; Perré, Patrick; Domenek, Sandra

    2018-03-01

    Nanocomposites are an opportunity to increase the performance of polymer membranes by fine-tuning their morphology. In particular, the understanding of the contribution of the polymer matrix/nanofiller interface to the overall transport properties is key to design membranes with tailored selective and adsorptive properties. In that aim, cellulose nanocrystals (CNC)/polylactide (PLA) nanocomposites were fabricated with chemically designed interfaces, which were ensuring the compatibility between the constituents and impacting the mass transport mechanism. A detailed analysis of the mass transport behaviour of different permeants in CNC/PLA nanocomposites was carried out as a function of their chemical affinity to grafted CNC surfaces. Penetrants (O 2 and cyclohexane), which were found to slightly interact with the constituents of the nanocomposites, provided information on the small tortuosity effect of CNC on diffusive mass transport. The mass transport of water (highly interacting with CNC) and anisole (interacting only with designed CNC surfaces) exhibited non-Fickian, Case II behaviour. The water vapour caused significant swelling of the CNC, which created a preferential pathway for mass transport. CNC surface grafting could attenuate this phenomenon and decrease the water transport rate. Anisole, an aromatic organic vapour, became reversibly trapped at the specifically designed CNC/PLA interface, but without any swelling or creation of an accelerated pathway. This caused the decrease of the overall mass transport rate. The latter finding could open a way to the creation of materials with specifically designed barrier properties by designing nanocomposites interfaces with specific interactions towards permeants. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. IAEA programme to support development and validation of advanced design and safety analysis codes

    Energy Technology Data Exchange (ETDEWEB)

    Choi, J., E-mail: J.H.Choi@iaea.org [International Atomic Energy Agency, Vienna (Austria)

    2013-07-01

    The International Atomic Energy Agency (IAEA) has been organized many international collaboration programs to support the development and validation of design and safety analysis computer codes for nuclear power plants. These programs are normally implemented with a frame of Coordinated Research Project (CRP) or International Collaborative Standard Problem (ICSP). This paper introduces CRPs and ICSPs currently being organized or recently completed by IAEA for this purpose. (author)

  4. Validity of a Newly-Designed Rectilinear Stepping Ergometer Submaximal Exercise Test to Assess Cardiorespiratory Fitness

    OpenAIRE

    Rubin Zhang, Likui Zhan, Shaoming Sun, Wei Peng, Yining Sun

    2017-01-01

    The maximum oxygen uptake (V̇O2 max), determined from graded maximal or submaximal exercise tests, is used to classify the cardiorespiratory fitness level of individuals. The purpose of this study was to examine the validity and reliability of the YMCA submaximal exercise test protocol performed on a newly-designed rectilinear stepping ergometer (RSE) that used up and down reciprocating vertical motion in place of conventional circular motion and giving precise measurement of workload, to det...

  5. The European contribution to the development and validation activities for the design of IFMIF lithium facility

    Energy Technology Data Exchange (ETDEWEB)

    Miccichè, Gioacchino, E-mail: gioacchino.micciche@enea.it [EURATOM-ENEA, CR Brasimone I-40035 Camugnano, BO (Italy); Aiello, Antonio; Bernardi, Davide; Favuzza, Paolo; Agostini, Pietro [EURATOM-ENEA, CR Brasimone I-40035 Camugnano, BO (Italy); Frisoni, Manuela [EURATOM-ENEA, CR Bologna I-40129, BO Italy (Italy); Pinna, Tonio; Porfiri, MariaTeresa [EURATOM-ENEA, CR Frascati I-0044 Frascati, Roma (Italy); Tincani, Amelia [EURATOM-ENEA, CR Brasimone I-40035 Camugnano, BO (Italy); Di Maio, PieroAlessandro [University of Palermo, I-90128 Palermo (Italy); Knaepen, Bernard [Université libre de Bruxelles, I-1050 Bruxelles (Belgium)

    2013-10-15

    Highlights: • Engineering design of the target assembly. • Erosion, corrosion phenomena promoted by the lithium are studied. • Purification system implemented in the LiFus6 loop. • Study of the remote handling maintenance for the IFMIF TA. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where candidate materials for fusion reactors will be tested and validated. The high energy neutron flux is produced by means of two deuteron beams (total current of 250 mA, energy of 40 MeV) that strikes a liquid lithium target circulating in a lithium loop of IFMIF plant. The European (EU) contribution to the development of the lithium facility comprises five procurement packages, as follow: (1) participation to the experimental activities of the EVEDA lithium test loop in Oarai (Japan); (2) study aimed at evaluating the corrosion and erosion phenomena, promoted by lithium, for structural fusion reference materials like AISI 316L and Eurofer; (3) design and validation of the lithium purification method with the aim to provide input data for the design of the purification system of IFIMF lithium loop; (4) design and validation of the remote handling (RH) procedures for the refurbishment/replacement of the EU concept of IFMIF target assembly including the design of the remote handling tools; (5) the engineering design of the European target assembly for IFMIF and the safety and RAMI analyses for the entire IFMIF lithium facility. The paper gives an overview of the status of the activities and of the main outcomes achieved so far.

  6. The European contribution to the development and validation activities for the design of IFMIF lithium facility

    International Nuclear Information System (INIS)

    Miccichè, Gioacchino; Aiello, Antonio; Bernardi, Davide; Favuzza, Paolo; Agostini, Pietro; Frisoni, Manuela; Pinna, Tonio; Porfiri, MariaTeresa; Tincani, Amelia; Di Maio, PieroAlessandro; Knaepen, Bernard

    2013-01-01

    Highlights: • Engineering design of the target assembly. • Erosion, corrosion phenomena promoted by the lithium are studied. • Purification system implemented in the LiFus6 loop. • Study of the remote handling maintenance for the IFMIF TA. -- Abstract: The International Fusion Materials Irradiation Facility (IFMIF) is an accelerator-driven intense neutron source where candidate materials for fusion reactors will be tested and validated. The high energy neutron flux is produced by means of two deuteron beams (total current of 250 mA, energy of 40 MeV) that strikes a liquid lithium target circulating in a lithium loop of IFMIF plant. The European (EU) contribution to the development of the lithium facility comprises five procurement packages, as follow: (1) participation to the experimental activities of the EVEDA lithium test loop in Oarai (Japan); (2) study aimed at evaluating the corrosion and erosion phenomena, promoted by lithium, for structural fusion reference materials like AISI 316L and Eurofer; (3) design and validation of the lithium purification method with the aim to provide input data for the design of the purification system of IFIMF lithium loop; (4) design and validation of the remote handling (RH) procedures for the refurbishment/replacement of the EU concept of IFMIF target assembly including the design of the remote handling tools; (5) the engineering design of the European target assembly for IFMIF and the safety and RAMI analyses for the entire IFMIF lithium facility. The paper gives an overview of the status of the activities and of the main outcomes achieved so far

  7. Thermodynamic properties of 1-naphthol: Mutual validation of experimental and computational results

    International Nuclear Information System (INIS)

    Chirico, Robert D.; Steele, William V.; Kazakov, Andrei F.

    2015-01-01

    Highlights: • Heat capacities were measured for the temperature range 5 K to 445 K. • Vapor pressures were measured for the temperature range 370 K to 570 K. • Computed and derived properties for ideal gas entropies are in excellent accord. • The enthalpy of combustion was measured and shown to be consistent with reliable literature values. • Thermodynamic consistency analysis revealed anomalous literature data. - Abstract: Thermodynamic properties for 1-naphthol (Chemical Abstracts registry number [90-15-3]) in the ideal-gas state are reported based on both experimental and computational methods. Measured properties included the triple-point temperature, enthalpy of fusion, and heat capacities for the crystal and liquid phases by adiabatic calorimetry; vapor pressures by inclined-piston manometry and comparative ebulliometry; and the enthalpy of combustion of the crystal phase by oxygen bomb calorimetry. Critical properties were estimated. Entropies for the ideal-gas state were derived from the experimental studies for the temperature range 298.15 ⩽ T/K ⩽ 600, and independent statistical calculations were performed based on molecular geometry optimization and vibrational frequencies calculated at the B3LYP/6-31+G(d,p) level of theory. The mutual validation of the independent experimental and computed results is achieved with a scaling factor of 0.975 applied to the calculated vibrational frequencies. This same scaling factor was successfully applied in the analysis of results for other polycyclic molecules, as described in a series of recent articles by this research group. This article reports the first extension of this approach to a hydroxy-aromatic compound. All experimental results are compared with property values reported in the literature. Thermodynamic consistency between properties is used to show that several studies in the literature are erroneous. The enthalpy of combustion for 1-naphthol was also measured in this research, and excellent

  8. Psychometric properties and validation of Nepali version of the Depression Anxiety Stress Scales (DASS-21).

    Science.gov (United States)

    Tonsing, Kareen N

    2014-04-01

    This study investigated the reliability of the Nepali version of the 21-item Depression Anxiety Stress Scale (DASS-21) among non-clinical sample. The purpose of this paper is to report the dimensionality and internal consistency of the DASS-21in a sample of non-clinical adults. This study was conducted in Hong Kong among 212 Nepali adults, aged 18-60 years. Life satisfaction was assessed with the Life Satisfaction Scale. The dimensionality of the DASS-21 scale was investigated using exploratory factor analysis. Construct validity was evaluated using the life satisfaction scale. The intercorrelation among depression, anxiety and stress subscales indicates that symptoms of psychological distress as measured by the DASS-21-N can distinguished between the three constructs in adult community sample. The results also showed inverse correlation among DASS-21-N and life satisfaction scale, supporting the assumption that the higher the life satisfaction, the lower the psychological distress. The results of this study indicate that the Nepali version of the DASS-21 demonstrate adequate psychometric properties in relation to internal consistency and validity, lending support to prior studies and suggest that the DASS-21 can be utilized among diverse groups with confidence. It supports the reliability of the 3-factorial dimensionality of the DASS-21, and highlight that it is a valid and useful tool that can distinguish between depression and anxiety. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Adjusted linguistic validation and psychometric properties of the Colombian version of KIDSCREEN-52.

    Science.gov (United States)

    Jaimes-Valencia, Mary Luz; Perpiñá-Galvañ, Juana; Cabañero-Martínez, Maria José; Cabrero-García, Julio; Richart-Martínez, Miguel

    2018-01-01

    In health and clinical studies, health-related quality of life is often assessed using the well-established KIDSCREEN-52 questionnaires as well as the Vécu et Santé Perçue de l'Adolescent (VSP-A). The purpose of this study was twofold: to perform an adjusted linguistic validation of the Colombian version of the KIDSCREEN-52 and to assess its psychometric properties in children and adolescents. A total of 146 children and adolescents completed the KIDSCREEN-52, adolescents ( n = 48) additionally completed the VSP-A. Psychometric analyses focused on the internal consistency as well as the convergent and discriminant validity of the KIDSCREEN-52 Colombian version. Syntactic and semantic modifications were made to 19 items in the adapted version of the KIDSCREEN-52. Cronbach's α ranged from .74 to .89 for eight dimensions, while α Colombian version of the KIDSCREEN-52 showed acceptable reliability and validity. This study provides a cultural adaptation of the Spanish version of the KIDSCREEN-52 for Colombian children and adolescents.

  10. Expert validation of fit-for-purpose guidelines for designing programmes of assessment

    Directory of Open Access Journals (Sweden)

    Dijkstra Joost

    2012-04-01

    Full Text Available Abstract Background An assessment programme, a purposeful mix of assessment activities, is necessary to achieve a complete picture of assessee competence. High quality assessment programmes exist, however, design requirements for such programmes are still unclear. We developed guidelines for design based on an earlier developed framework which identified areas to be covered. A fitness-for-purpose approach defining quality was adopted to develop and validate guidelines. Methods First, in a brainstorm, ideas were generated, followed by structured interviews with 9 international assessment experts. Then, guidelines were fine-tuned through analysis of the interviews. Finally, validation was based on expert consensus via member checking. Results In total 72 guidelines were developed and in this paper the most salient guidelines are discussed. The guidelines are related and grouped per layer of the framework. Some guidelines were so generic that these are applicable in any design consideration. These are: the principle of proportionality, rationales should underpin each decisions, and requirement of expertise. Logically, many guidelines focus on practical aspects of assessment. Some guidelines were found to be clear and concrete, others were less straightforward and were phrased more as issues for contemplation. Conclusions The set of guidelines is comprehensive and not bound to a specific context or educational approach. From the fitness-for-purpose principle, guidelines are eclectic, requiring expertise judgement to use them appropriately in different contexts. Further validation studies to test practicality are required.

  11. The Spanish-Version of the Subjective Vitality Scale: Psychometric Properties and Evidence of Validity.

    Science.gov (United States)

    Castillo, Isabel; Tomás, Inés; Balaguer, Isabel

    2017-06-05

    The Subjective Vitality Scale (SVS) assess the subjective experience of being full of energy and alive, a clinically relevant outcome measure of positive psychological well-being. The purpose of this paper was to translate the 7-item SVS into Spanish and examine its psychometric properties. In Study 1 (n = 790 adolescents) and Study 2 (n = 130 athletes) reliability and exploratory factor analysis (EFA) were carried out. In Study 1 and Study 3 (n = 197 dancers) evidence of validity of inferences based on SVS scores estimating relationships with other variables (life satisfaction, global self-esteem and emotional and physical exhaustion) was obtained. In Study 2 invariance across time was tested. Finally in Study 3, the factorial structure was cross-validated using confirmatory factor analysis (CFA). Results of EFA showed a one-factor solution. CFA also supported a unidimensional factor structure for the Spanish 6-item SVS (RMSEA = .050 (90% CI = .00, .080); NNFI = .993; CFI = .996). Reliability analysis indicated a strong internal consistency in all study samples (α ranged from .82 to .89). Further, results from multi-sample analysis supported the replicability of SVS factor structure across time. Finally, the SVS scores showed the expected correlations patterns (all them significant, p < .01) with the measured outcomes. In conclusion, the Spanish version of the SVS demonstrated adequate psychometric properties, indicating that the scale can be confidently used to measure the experience of possessing energy and aliveness; furthermore, differences across time can be meaningfully carried out.

  12. VALIDATION OF SIMULATION MODELS FOR DIFFERENTLY DESIGNED HEAT-PIPE EVACUATED TUBULAR COLLECTORS

    DEFF Research Database (Denmark)

    Fan, Jianhua; Dragsted, Janne; Furbo, Simon

    2007-01-01

    Differently designed heat-pipe evacuated tubular collectors have been investigated theoretically and experimentally. The theoretical work has included development of two TRNSYS [1] simulation models for heat-pipe evacuated tubular collectors utilizing solar radiation from all directions. One model...... coating on both sides. The input to the models is thus not a simple collector efficiency expression but the actual collector geometry. In this study, the TRNSYS models are validated with measurements for four differently designed heat-pipe evacuated tubular collectors. The collectors are produced...

  13. The mechanical design and validation of the helical tube boilers for Hartlepool and Heysham AGR stations

    International Nuclear Information System (INIS)

    Skinner, V.R.

    1983-01-01

    The 32 helically coiled once-through boiler units at Hartlepool and Heysham represent a major advance in the technologies of boiler design, manufacture and site construction. They are particularly complex in that they incorporate integral reheaters; they employ three different tubing materials and five different structural materials, each with operating temperature limitations; and they must fit compactly into pods in the reactor pressure vessel walls. A general description of the boilers is followed by a review of external factors which influenced the mechanical design and validation programme over 15 years. Against this background selected components are discussed in detail in terms of particular loading conditions and stress analysis. (author)

  14. The Validity and Precision of the Comparative Interrupted Time-Series Design: Three Within-Study Comparisons

    Science.gov (United States)

    St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

    2016-01-01

    We explore the conditions under which short, comparative interrupted time-series (CITS) designs represent valid alternatives to randomized experiments in educational evaluations. To do so, we conduct three within-study comparisons, each of which uses a unique data set to test the validity of the CITS design by comparing its causal estimates to…

  15. Assessing decentering: validation, psychometric properties, and clinical usefulness of the Experiences Questionnaire in a Spanish sample.

    Science.gov (United States)

    Soler, Joaquim; Franquesa, Alba; Feliu-Soler, Albert; Cebolla, Ausias; García-Campayo, Javier; Tejedor, Rosa; Demarzo, Marcelo; Baños, Rosa; Pascual, Juan Carlos; Portella, Maria J

    2014-11-01

    Decentering is defined as the ability to observe one's thoughts and feelings in a detached manner. The Experiences Questionnaire (EQ) is a self-report instrument that originally assessed decentering and rumination. The purpose of this study was to evaluate the psychometric properties of the Spanish version of EQ-Decentering and to explore its clinical usefulness. The 11-item EQ-Decentering subscale was translated into Spanish and psychometric properties were examined in a sample of 921 adult individuals, 231 with psychiatric disorders and 690 without. The subsample of nonpsychiatric participants was also split according to their previous meditative experience (meditative participants, n=341; and nonmeditative participants, n=349). Additionally, differences among these three subgroups were explored to determine clinical validity of the scale. Finally, EQ-Decentering was administered twice in a group of borderline personality disorder, before and after a 10-week mindfulness intervention. Confirmatory factor analysis indicated acceptable model fit, sbχ(2)=243.8836 (p.46; and divergent validity: r<-.35). The scale detected changes in decentering after a 10-session intervention in mindfulness (t=-4.692, p<.00001). Differences among groups were significant (F=134.8, p<.000001), where psychiatric participants showed the lowest scores compared to nonpsychiatric meditative and nonmeditative participants. The Spanish version of the EQ-Decentering is a valid and reliable instrument to assess decentering either in clinical and nonclinical samples. In addition, the findings show that EQ-Decentering seems an adequate outcome instrument to detect changes after mindfulness-based interventions. Copyright © 2014. Published by Elsevier Ltd.

  16. Validating Satellite-Retrieved Cloud Properties for Weather and Climate Applications

    Science.gov (United States)

    Minnis, P.; Bedka, K. M.; Smith, W., Jr.; Yost, C. R.; Bedka, S. T.; Palikonda, R.; Spangenberg, D.; Sun-Mack, S.; Trepte, Q.; Dong, X.; Xi, B.

    2014-12-01

    Cloud properties determined from satellite imager radiances are increasingly used in weather and climate applications, particularly in nowcasting, model assimilation and validation, trend monitoring, and precipitation and radiation analyses. The value of using the satellite-derived cloud parameters is determined by the accuracy of the particular parameter for a given set of conditions, such as viewing and illumination angles, surface background, and cloud type and structure. Because of the great variety of those conditions and of the sensors used to monitor clouds, determining the accuracy or uncertainties in the retrieved cloud parameters is a daunting task. Sensitivity studies of the retrieved parameters to the various inputs for a particular cloud type are helpful for understanding the errors associated with the retrieval algorithm relative to the plane-parallel world assumed in most of the model clouds that serve as the basis for the retrievals. Real world clouds, however, rarely fit the plane-parallel mold and generate radiances that likely produce much greater errors in the retrieved parameter than can be inferred from sensitivity analyses. Thus, independent, empirical methods are used to provide a more reliable uncertainty analysis. At NASA Langley, cloud properties are being retrieved from both geostationary (GEO) and low-earth orbiting (LEO) satellite imagers for climate monitoring and model validation as part of the NASA CERES project since 2000 and from AVHRR data since 1978 as part of the NOAA CDR program. Cloud properties are also being retrieved in near-real time globally from both GEO and LEO satellites for weather model assimilation and nowcasting for hazards such as aircraft icing. This paper discusses the various independent datasets and approaches that are used to assessing the imager-based satellite cloud retrievals. These include, but are not limited to data from ARM sites, CloudSat, and CALIPSO. This paper discusses the use of the various

  17. The design and modeling of periodic materials with novel properties

    Science.gov (United States)

    Berger, Jonathan Bernard

    Cellular materials are ubiquitous in our world being found in natural and engineered systems as structural materials, sound and energy absorbers, heat insulators and more. Stochastic foams made of polymers, metals and even ceramics find wide use due to their novel properties when compared to monolithic materials. Properties of these so called hybrid materials, those that combine materials or materials and space, are derived from the localization of thermomechanical stresses and strains on the mesoscale as a function of cell topology. The effects of localization can only be generalized in stochastic materials arising from their inherent potential complexity, possessing variations in local chemistry, microstructural inhomogeneity and topological variations. Ordered cellular materials on the other hand, such as lattices and honeycombs, make for much easier study, often requiring analysis of only a single unit-cell. Theoretical bounds predict that hybrid materials have the potential to push design envelopes offering lighter stiffer and stronger materials. Hybrid materials can achieve very low and even negative coefficients of thermal expansion (CTE) while retaining a relatively high stiffness -- properties completely unmatched by monolithic materials. In the first chapter of this thesis a two-dimensional lattice is detailed that possess near maximum stiffness, relative to the tightest theoretical bound, and low, zero and even appreciably negative thermal expansion. Its CTE and stiffness are given in closed form as a function of geometric parameters and the material properties. This result is confirmed with finite elements (FE) and experiment. In the second chapter the compressive stiffness of three-dimensional ordered foams, both closed and open cell, are predicted with FE and the results placed in property space in terms of stiffness and density. A novel structure is identified that effectively achieves theoretical bounds for Young's, shear and bulk modulus

  18. Property Integration - A New Approach for Simultaneous Solution of Process and Molecular Design Problems

    DEFF Research Database (Denmark)

    The objective of this paper is to introduce the new concept of property integration. It is based on tracking and integrating properties throughout the process. This is made possible by exploiting the unique features at the interface of process and molecular design. Recently developed clustering...... concepts are employed to identify optimal properties without commitment to specific species. Subsequently, group contribution methods and molecular design techniques are employed to solve the reverse property prediction problem to design molecules possessing the optimal properties....

  19. Validation of the Nuclear Design Method for MOX Fuel Loaded LWR Cores

    International Nuclear Information System (INIS)

    Saji, E.; Inoue, Y.; Mori, M.; Ushio, T.

    2001-01-01

    The actual batch loading of mixed-oxide (MOX) fuel in light water reactors (LWRs) is now ready to start in Japan. One of the efforts that have been devoted to realizing this batch loading has been validation of the nuclear design methods calculating the MOX-fuel-loaded LWR core characteristics. This paper summarizes the validation work for the applicability of the CASMO-4/SIMULATE-3 in-core fuel management code system to MOX-fuel-loaded LWR cores. This code system is widely used by a number of electric power companies for the core management of their commercial LWRs. The validation work was performed for both boiling water reactor (BWR) and pressurized water reactor (PWR) applications. Each validation consists of two parts: analyses of critical experiments and core tracking calculations of operating plants. For the critical experiments, we have chosen a series of experiments known as the VENUS International Program (VIP), which was performed at the SCK/CEN MOL laboratory in Belgium. VIP consists of both BWR and PWR fuel assembly configurations. As for the core tracking calculations, the operating data of MOX-fuel-loaded BWR and PWR cores in Europe have been utilized

  20. Participatory action research designs in applied disability and rehabilitation science: protecting against threats to social validity.

    Science.gov (United States)

    Seekins, Tom; White, Glen W

    2013-01-01

    Researchers and disability advocates have been debating consumer involvement in disability and rehabilitation science since at least 1972. Despite the length of this debate, much confusion remains. Consumer involvement may represent a spirit of democracy or even empowerment, but as a tool of science, it is necessary to understand how to judge its application. To realize consumer involvement as a design element in science, researchers need a framework for understanding how it can contribute to the scientific process. The thesis of this article is that a primary scientific function of consumer involvement is to reduce threats to the social validity of research, the extent to which those expected to use or benefit from research products judge them as useful and actually use them. Social validity has traditionally not been treated with the same rigor as concerns for internal and external validity. This article presents a framework that describes 7 threats to social validity and explains how 15 forms of consumer involvement protect against those threats. We also suggest procedures for reporting and reviewing consumer involvement in proposals and manuscripts. This framework offers tools familiar to all scientists for identifying threats to the quality of research, and for judging the effectiveness of strategies for protecting against those threats. It may also enhance the standing of consumer involvement strategies as tools for protecting research quality by organizing them in a way that allows for systematic criticism of their effectiveness and subsequent improvement. Copyright © 2013 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  1. [DESIGN AND VALIDATION OF AN IMAGE FOR DISSEMINATION AND IMPLEMENTATION OF CHILEAN DIETARY GUIDELINES].

    Science.gov (United States)

    Olivares Cortés, Sonia; Zacarías Hasbún, Isabel; González González, Carmen Gloria; Fonseca Morán, Lilian; Mediano Stoltze, Fernanda; Pinheiro Fernandes, Anna Christina; Rodríguez Osiac, Lorena

    2015-08-01

    Food-Based Dietary Guidelines (FBDG) are usually accompanied by an image for dissemination and implementation. to design and validate an image to represent the variety and proportions of the new Chilean dietary guidelines, include foods high in critical nutrients that should be avoided and physical activity guidelines. a panel of experts tested seven graphics and selected three that were validated with 12 focus groups of people aged 10-14 and 20-40 years, of both sexes, from different socioeconomic groups and from both rural and urban areas. We analyzed the perception of variety and proportions of the food groups for daily intake and motivation for action in diet and physical activity. We utilized the METAPLAN method used previously in the validation of FBDG. the final image was a circle that showed the variety and proportions of each food group for daily consumption (in pictures), included physical activity guidelines in a strip around the middle of the circle and a rectangle towards of bottom of the image with examples of foods high in critical nutrients in black and white. The chosen picture was modified using input from participants and validated with three additional focus groups, improving its understanding and acceptance. most participants understood that the image represented the relationship between healthy eating and daily physical activity, correctly identifying the food groups for which increased intake was suggested and those groups in which intake should be reduced or avoided. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  2. The design and validation of advanced operator support systems for a role in plant safety

    International Nuclear Information System (INIS)

    Hughes, G.

    1989-06-01

    Advanced operator support systems have the potential of making a significant contribution to plant safety. This note reviews the different support functions required, the specification of performance criteria and possible approaches for system validation. The importance of the different functions that can be provided is related to the stage of the accident sequence. Also, because of the restricted reliability of any single system, subdivision of the systems is suggested in order to make the maximum contribution at a number of sequential stages. In this way it should be possible to make a significant claim for reduced operator error over the full accident progression, from incipient fault to disaster. The use of performance criteria currently associated with the classification of safety-grade trip systems (e.g. detection failure probability) would seem to provide a sound basis for validation. The validation of systems is seen as a significant task which will rely on the use of design and training-simulator data together with specific plant measurements. Expert systems appear to present particular problems for validation. (author)

  3. Design and validity of a questionnaire to assess sexuality in pregnant women

    Directory of Open Access Journals (Sweden)

    Barbosa Angélica P

    2009-07-01

    Full Text Available Abstract Background A review of validated methods for assessing female sexual dysfunction and a review of male and female sexual dysfunction did not refer to any specific questionnaire for evaluating sexuality during pregnancy. A study was performed at the Obstetrics and Gynecology Department of Botucatu Medical School, São Paulo State University, Brazil to design and validate a pregnancy sexuality questionnaire, the Pregnancy Sexual Response Inventory (PSRI. Methods Women with a singleton pregnancy between 10 and 35 weeks of gestation were randomly recruited. There were five phases in the development of the PSRI: (1 item selection; (2 item development; (3 determination of internal consistency, reliability and convergence; (4 content validity; and (5 determination of inter-interviewer reliability. Internal consistency and reliability were evaluated using Cronbach's alpha. Inter-interviewer reliability was assessed by evaluating the responses of 18 academics at various institutions, using Kappa Index and Student t test. Results Good internal consistency and reliability were obtained (Cronbach's alpha coefficient = 0.79. Among the 18 academics, 13 totally agreed (K = 1.0, three partially agreed (K = 0.67 and two disagreed (K = 0.33 with the proposed questions. Comparisons of the mean PSRI domain scores made between the primary investigators and the other interviewers showed no significant differences in all domains (p > 0.05. Conclusion PSRI is a new validated instrument for evaluating sexuality and sexual activity and related health concerns during pregnancy.

  4. Designing and validation of a yoga-based intervention for obsessive compulsive disorder.

    Science.gov (United States)

    Bhat, Shubha; Varambally, Shivarama; Karmani, Sneha; Govindaraj, Ramajayam; Gangadhar, B N

    2016-06-01

    Some yoga-based practices have been found to be useful for patients with obsessive compulsive disorder (OCD). The authors could not find a validated yoga therapy module available for OCD. This study attempted to formulate a generic yoga-based intervention module for OCD. A yoga module was designed based on traditional and contemporary yoga literature. The module was sent to 10 yoga experts for content validation. The experts rated the usefulness of the practices on a scale of 1-5 (5 = extremely useful). The final version of the module was pilot-tested on patients with OCD (n = 17) for both feasibility and effect on symptoms. Eighty-eight per cent (22 out of 25) of the items in the initial module were retained, with modifications in the module as suggested by the experts along with patients' inputs and authors' experience. The module was found to be feasible and showed an improvement in symptoms of OCD on total Yale-Brown Obsessive-Compulsive Scale (YBOCS) score (p = 0.001). A generic yoga therapy module for OCD was validated by experts in the field and found feasible to practice in patients. A decrease in the symptom scores was also found following yoga practice of 2 weeks. Further clinical validation is warranted to confirm efficacy.

  5. Design and validation of a questionnaire on nursing competence in the notification of medication incidents.

    Science.gov (United States)

    Salcedo-Diego, Isabel; de Andrés-Gimeno, Begoña; Ruiz-Antorán, Belén; Layunta, Rocío; Serrano-Gallardo, Pilar

    To design and perform a face and content validation of a questionnaire to measure the competence of hospital RN to report medication incidents. Content and face questionnaire validation descriptive study. A review of the literature was performed for the creation of ítems. A panel of six experts assessed the relevance of the inclusion of each ítem in the questionnaire by calculating the position index; ítems with position index >0.70 were selected. The questionnaire was piloted by 59 RN. Finally, a meeting was convened with experts, in order to reduce the length of the piloted questionnaire through review, discussion and decision by consensus on each item. From the literature review, a battery of 151 ítems grouped into three elements of competence: attitudes, knowledge and skills was created. 52.9% (n=80) of the ítems received a position index > 0.70. The response rate in the pilot study was 40.65%. The median time to complete the questionnaire was 23:35minutes. After reduction by the experts, the final questionnaire comprised 45 ítems grouped into 32 questions. The NORMA questionnaire, designed to explore the competence of hospital RN to report medication incidents, has adequate face and content validity and is easy to administer, enabling its institutional implementation. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  6. Design and validation of a questionnaire to evaluate the usability of computerized critical care information systems.

    Science.gov (United States)

    von Dincklage, Falk; Lichtner, Gregor; Suchodolski, Klaudiusz; Ragaller, Maximilian; Friesdorf, Wolfgang; Podtschaske, Beatrice

    2017-08-01

    The implementation of computerized critical care information systems (CCIS) can improve the quality of clinical care and staff satisfaction, but also holds risks of disrupting the workflow with consecutive negative impacts. The usability of CCIS is one of the key factors determining their benefits and weaknesses. However, no tailored instrument exists to measure the usability of such systems. Therefore, the aim of this study was to design and validate a questionnaire that measures the usability of CCIS. Following a mixed-method design approach, we developed a questionnaire comprising two evaluation models to assess the usability of CCIS: (1) the task-specific model rates the usability individually for several tasks which CCIS could support and which we derived by analyzing work processes in the ICU; (2) the characteristic-specific model rates the different aspects of the usability, as defined by the international standard "ergonomics of human-system interaction". We tested validity and reliability of the digital version of the questionnaire in a sample population. In the sample population of 535 participants both usability evaluation models showed a strong correlation with the overall rating of the system (multiple correlation coefficients ≥0.80) as well as a very high internal consistency (Cronbach's alpha ≥0.93). The novel questionnaire is a valid and reliable instrument to measure the usability of CCIS and can be used to study the influence of the usability on their implementation benefits and weaknesses.

  7. Design and Technical Validation of a Telemedicine Service for Rural Healthcare in Ecuador.

    Science.gov (United States)

    Vasquez-Cevallos, Leonel A; Bobokova, Jana; González-Granda, Patricia V; Iniesta, José M; Gómez, Enrique J; Hernando, M Elena

    2017-12-12

    Telemedicine is becoming increasingly important in Ecuador, especially in areas such as rural primary healthcare and medical education. Rural telemedicine programs in the country need to be strengthened by means of a technological platform adapted to local surroundings and offering advantages such as access to specialized care, continuing education, and so on, combined with modest investment requirements. This present article presents the design of a Telemedicine Platform (TMP) for rural healthcare services in Ecuador and a preliminary technical validation with medical students and teachers. An initial field study was designed to capture the requirements of the TMP. In a second phase, the TMP was validated in an academic environment along three consecutive academic courses. Assessment was by means of user polls and analyzing user interactions as registered automatically by the platform. The TMP was developed using Web-based technology and open code software. One hundred twenty-four students and 6 specialized faculty members participated in the study, conducting a total of 262 teleconsultations of clinical cases and 226 responses, respectively. The validation results show that the TMP is a useful communication tool for the documentation and discussion of clinical cases. Moreover, its usage may be recommended as a teaching methodology, to strengthen the skills of medical undergraduates. The results indicate that implementing the system in rural healthcare services in Ecuador would be feasible.

  8. Validations of BWR nuclear design code using ABWR MOX numerical benchmark problems

    International Nuclear Information System (INIS)

    Takano, Shou; Sasagawa, Masaru; Yamana, Teppei; Ikehara, Tadashi; Yanagisawa, Naoki

    2017-01-01

    BWR core design code package (the HINES assembly code and the PANACH core simulator), being used for full MOX-ABWR core design, has been benchmarked against the high-fidelity numerical solutions as references, for the purpose of validating its capability of predicting the BWR core design parameters systematically from UO 2 to 100% MOX cores. The reference solutions were created by whole core critical calculations using MCNPs with the precisely modeled ABWR cores both in hot and cold conditions at BOC and EOC of the equilibrium cycle. A Doppler-Broadening Rejection Correction (DCRB) implemented MCNP5-1.4 with ENDF/B-VII.0 was mainly used to evaluate the core design parameters, except for effective delayed neutron fraction (β eff ) and prompt neutron lifetime (l) with MCNP6.1. The discrepancies in the results between the design codes HINES-PANACH and MCNPs for the core design parameters such as the bundle powers, hot pin powers, control rod worth, boron worth, void reactivity, Doppler reactivity, β eff and l, are almost within target accuracy, leading to the conclusion that HINES-PANACH has sufficient fidelity for application to full MOX-ABWR core design. (author)

  9. A methodology for the validated design space exploration of fuel cell powered unmanned aerial vehicles

    Science.gov (United States)

    Moffitt, Blake Almy

    Unmanned Aerial Vehicles (UAVs) are the most dynamic growth sector of the aerospace industry today. The need to provide persistent intelligence, surveillance, and reconnaissance for military operations is driving the planned acquisition of over 5,000 UAVs over the next five years. The most pressing need is for quiet, small UAVs with endurance beyond what is capable with advanced batteries or small internal combustion propulsion systems. Fuel cell systems demonstrate high efficiency, high specific energy, low noise, low temperature operation, modularity, and rapid refuelability making them a promising enabler of the small, quiet, and persistent UAVs that military planners are seeking. Despite the perceived benefits, the actual near-term performance of fuel cell powered UAVs is unknown. Until the auto industry began spending billions of dollars in research, fuel cell systems were too heavy for useful flight applications. However, the last decade has seen rapid development with fuel cell gravimetric and volumetric power density nearly doubling every 2--3 years. As a result, a few design studies and demonstrator aircraft have appeared, but overall the design methodology and vehicles are still in their infancy. The design of fuel cell aircraft poses many challenges. Fuel cells differ fundamentally from combustion based propulsion in how they generate power and interact with other aircraft subsystems. As a result, traditional multidisciplinary analysis (MDA) codes are inappropriate. Building new MDAs is difficult since fuel cells are rapidly changing in design, and various competitive architectures exist for balance of plant, hydrogen storage, and all electric aircraft subsystems. In addition, fuel cell design and performance data is closely protected which makes validation difficult and uncertainty significant. Finally, low specific power and high volumes compared to traditional combustion based propulsion result in more highly constrained design spaces that are

  10. Design and properties of advanced {gamma}(TiAl) alloys

    Energy Technology Data Exchange (ETDEWEB)

    Appel, F; Clemens, H; Oehring, M [Institute for Materials Research, GKSS Research Centre, Max-Planck-Strasse, D-21502 Geesthacht (Germany)

    2001-07-01

    Intermetallic titanium aluminides are one of the few classes of emerging materials that have the potential to be used in demanding high-temperature structural applications whenever specific strength and stiffness are of major concern. However, in order to effectively replace the heavier nickel-base superalloys currently use, titanium aluminides must combine a wide range of mechanical property capabilities. Advanced alloy designs are tailored for strength, toughness, creep resistance, and environmental stability. Some of these concerns are addressed in the present paper through global commentary on the physical metallurgy and technology of gamma TiAl-base alloys. Particular emphasis is paid on recent developments of TiAl alloys with enhanced high-temperature capability. (author)

  11. Design, Properties and Recent Application of Macrocycles in Medicinal Chemistry.

    Science.gov (United States)

    Ermert, Philipp

    2017-10-25

    Macrocyclic compounds have recently received increasing attention in drug discovery as these compounds offer the potential to modulate difficult targets and to access novel chemotypes. Approaches towards libraries of macrocyclic compounds based on modular organic synthesis and applications of these technology platforms to find and improve biologically active compounds are introduced in this minireview. Alternatively, lead compounds may be obtained by truncation and modification of macrocyclic natural products. Selected medicinal chemistry programs are discussed, illustrating a macrocyclization approach toward ligands with improved properties. The design of such ligands is often informed by X-ray crystal structures of protein-ligand complexes. Efforts to understand cellular permeability and oral bioavailability of cyclic peptides and non-peptidic macrocycles are summarized.

  12. Property Model-Based Chemcal Substitution and Chemical Formulation Design

    DEFF Research Database (Denmark)

    Jhamb, Spardha Virendra; Liang, Xiaodong; Hukkerikar, Amol Shivajirao

    Chemical-based products including structured product formulations and single molecule products have proven to be a boon to mankind and have been a significant part of our economies. Our life and the changes around us cannot be imagined without the presence or involvement of chemicals. But like...... with environmentally benign chemicals. Additionally, the decisions taken during chemical product design also have an impact on the process and product performance and are influenced by company strategy, availability of market and government policies [2]. Hence, undoubtedly there is a need to develop a systematic...... [3] will also be highlighted. A set of new group contribution-based models for a number of useful properties of amino acids will be presented. Through examples on substitution of chemicals from chemical-based products from various sectors namely cosmetics and personal care, pharmaceutical and food...

  13. Design and properties of advanced γ(TiAl) alloys

    International Nuclear Information System (INIS)

    Appel, F.; Clemens, H.; Oehring, M.

    2001-01-01

    Intermetallic titanium aluminides are one of the few classes of emerging materials that have the potential to be used in demanding high-temperature structural applications whenever specific strength and stiffness are of major concern. However, in order to effectively replace the heavier nickel-base superalloys currently use, titanium aluminides must combine a wide range of mechanical property capabilities. Advanced alloy designs are tailored for strength, toughness, creep resistance, and environmental stability. Some of these concerns are addressed in the present paper through global commentary on the physical metallurgy and technology of gamma TiAl-base alloys. Particular emphasis is paid on recent developments of TiAl alloys with enhanced high-temperature capability. (author)

  14. Design properties of coal liquids: edited workshop proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Brinkman, D.W.; Reilly, M.J. (eds.)

    1981-08-01

    The advent of synfuels will require a large measurement and modeling effort of new thermodynamic and physical properties. These data are required for the economic design and operation of proposed synfuel plants. The areas of data need are well defined. The pace of measurement will be restricted by laboratory availability. The cost for the required data and for their correlation and modeling will be substantial. And finally, the cost of doing all this work will be substantial. The plants we are talking about are energy plants and synfuel plants. They are energy intensive plants, and as such, they offer the prospects for a great deal of energy saving. To do so requires good data. In those critical areas where we start hunting the energy hogs, we will find that with +-20% data those hogs are pretty well hidden.

  15. ICAS-PAT: A Software for Design, Analysis and Validation of PAT Systems

    DEFF Research Database (Denmark)

    Singh, Ravendra; Gernaey, Krist; Gani, Rafiqul

    2010-01-01

    end product qualities. In an earlier article, Singh et al. [Singh, R., Gernaey, K. V., Gani, R. (2009). Model-based computer-aided framework for design of process monitoring and analysis systems. Computers & Chemical Engineering, 33, 22–42] proposed the use of a systematic model and data based...... methodology to design appropriate PAT systems. This methodology has now been implemented into a systematic computer-aided framework to develop a software (ICAS-PAT) for design, validation and analysis of PAT systems. Two supporting tools needed by ICAS-PAT have also been developed: a knowledge base...... (consisting of process knowledge as well as knowledge on measurement methods and tools) and a generic model library (consisting of process operational models). Through a tablet manufacturing process example, the application of ICAS-PAT is illustrated, highlighting as well, the main features of the software....

  16. MR-based Water Content Estimation in Cartilage: Design and Validation of a Method

    DEFF Research Database (Denmark)

    Shiguetomi Medina, Juan Manuel; Kristiansen, Maja Sofie; Ringgaard, Steffen

    2012-01-01

    Objective Design and validation of an MR-based method that allows the calculation of the water content in cartilage tissue. Material and Methods We modified and adapted to cartilage tissue T1 map based water content MR sequences commonly used in the neurology field. Using a 37 Celsius degree stable...... was costumed and programmed. Finally, we validated the method after measuring and comparing 3 more cartilage samples in a living animal (pig). The obtained data was analyzed and the water content calculated. Then, the same samples were freeze-dried (this technique allows to take out all the water that a tissue...... contains) and we measured the water they contained. Results We could reproduce twice the 37 Celsius degree system and could perform the measurements in a similar way. We found that the MR T1 map based water content sequences can provide information that, after being analyzed with a special software, can...

  17. MR-based water content estimation in cartilage: design and validation of a method

    DEFF Research Database (Denmark)

    Shiguetomi Medina, Juan Manuel; Kristiansen, Maja Sophie; Ringgaard, Steffen

    Purpose: Design and validation of an MR-based method that allows the calculation of the water content in cartilage tissue. Methods and Materials: Cartilage tissue T1 map based water content MR sequences were used on a 37 Celsius degree stable system. The T1 map intensity signal was analyzed on 6...... cartilage samples from living animals (pig) and on 8 gelatin samples which water content was already known. For the data analysis a T1 intensity signal map software analyzer used. Finally, the method was validated after measuring and comparing 3 more cartilage samples in a living animal (pig). The obtained...... map based water content sequences can provide information that, after being analyzed using a T1-map analysis software, can be interpreted as the water contained inside a cartilage tissue. The amount of water estimated using this method was similar to the one obtained at the dry-freeze procedure...

  18. Advanced control and instrumentation systems in nuclear power plants. Design, verification and validation

    International Nuclear Information System (INIS)

    Haapanen, P.

    1995-01-01

    The Technical Committee Meeting on design, verification and validation of advanced control and instrumentation systems in nuclear power plants was held in Espoo, Finland on 20 - 23 June 1994. The meeting was organized by the International Atomic Energy Agency's (IAEA) International Working Group's (IWG) on Nuclear Power Plant Control and Instrumentation (NPPCI) and on Advanced Technologies for Water Cooled Reactors (ATWR). VTT Automation together with Imatran Voima Oy and Teollisuuden Voima Oy responded about the practical arrangements of the meeting. In total 96 participants from 21 countries and the Agency took part in the meeting and 34 full papers and 8 posters were presented. Following topics were covered in the papers: (1) experience with advanced and digital systems, (2) safety and reliability analysis, (3) advanced digital systems under development and implementation, (4) verification and validation methods and practices, (5) future development trends. (orig.)

  19. Design and Experimental Validation of Hydraulic Yaw System for Multi MW Wind Turbine

    DEFF Research Database (Denmark)

    Stubkier, Søren; Pedersen, Henrik C.; Andersen, Torben Ole

    2013-01-01

    market. A hydraulic yaw system is such a new technology, and so a mathematical model of the full scale system and test rig system is derived and compared to measurements from the system. This is done in order to have a validated model, which wind turbine manufacturers may use for test in their simulation......To comply with the increasing demands for life time and reliability of wind turbines as these grow in size, new measures needs to be taken in the design of wind turbines and components hereof. One critical point is the initial testing of the components and systems before they are implemented...... in an actual turbine. Full scale hardware testing is both extremely expensive and time consuming, and so the wind turbine industry moves more towards simulations when testing. In order to meet these demands it is necessary with valid models of systems in order to introduce new technologies to the wind turbine...

  20. Computational Design and Discovery of Ni-Based Alloys and Coatings: Thermodynamic Approaches Validated by Experiments

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Zi-Kui [Pennsylvania State University; Gleeson, Brian [University of Pittsburgh; Shang, Shunli [Pennsylvania State University; Gheno, Thomas [University of Pittsburgh; Lindwall, Greta [Pennsylvania State University; Zhou, Bi-Cheng [Pennsylvania State University; Liu, Xuan [Pennsylvania State University; Ross, Austin [Pennsylvania State University

    2018-04-23

    This project developed computational tools that can complement and support experimental efforts in order to enable discovery and more efficient development of Ni-base structural materials and coatings. The project goal was reached through an integrated computation-predictive and experimental-validation approach, including first-principles calculations, thermodynamic CALPHAD (CALculation of PHAse Diagram), and experimental investigations on compositions relevant to Ni-base superalloys and coatings in terms of oxide layer growth and microstructure stabilities. The developed description included composition ranges typical for coating alloys and, hence, allow for prediction of thermodynamic properties for these material systems. The calculation of phase compositions, phase fraction, and phase stabilities, which are directly related to properties such as ductility and strength, was a valuable contribution, along with the collection of computational tools that are required to meet the increasing demands for strong, ductile and environmentally-protective coatings. Specifically, a suitable thermodynamic description for the Ni-Al-Cr-Co-Si-Hf-Y system was developed for bulk alloy and coating compositions. Experiments were performed to validate and refine the thermodynamics from the CALPHAD modeling approach. Additionally, alloys produced using predictions from the current computational models were studied in terms of their oxidation performance. Finally, results obtained from experiments aided in the development of a thermodynamic modeling automation tool called ESPEI/pycalphad - for more rapid discovery and development of new materials.

  1. Ares I-X Flight Test Validation of Control Design Tools in the Frequency-Domain

    Science.gov (United States)

    Johnson, Matthew; Hannan, Mike; Brandon, Jay; Derry, Stephen

    2011-01-01

    A major motivation of the Ares I-X flight test program was to Design for Data, in order to maximize the usefulness of the data recorded in support of Ares I modeling and validation of design and analysis tools. The Design for Data effort was intended to enable good post-flight characterizations of the flight control system, the vehicle structural dynamics, and also the aerodynamic characteristics of the vehicle. To extract the necessary data from the system during flight, a set of small predetermined Programmed Test Inputs (PTIs) was injected directly into the TVC signal. These PTIs were designed to excite the necessary vehicle dynamics while exhibiting a minimal impact on loads. The method is similar to common approaches in aircraft flight test programs, but with unique launch vehicle challenges due to rapidly changing states, short duration of flight, a tight flight envelope, and an inability to repeat any test. This paper documents the validation effort of the stability analysis tools to the flight data which was performed by comparing the post-flight calculated frequency response of the vehicle to the frequency response calculated by the stability analysis tools used to design and analyze the preflight models during the control design effort. The comparison between flight day frequency response and stability tool analysis for flight of the simulated vehicle shows good agreement and provides a high level of confidence in the stability analysis tools for use in any future program. This is true for both a nominal model as well as for dispersed analysis, which shows that the flight day frequency response is enveloped by the vehicle s preflight uncertainty models.

  2. Design of experiments in medical physics: Application to the AAA beam model validation.

    Science.gov (United States)

    Dufreneix, S; Legrand, C; Di Bartolo, C; Bremaud, M; Mesgouez, J; Tiplica, T; Autret, D

    2017-09-01

    The purpose of this study is to evaluate the usefulness of the design of experiments in the analysis of multiparametric problems related to the quality assurance in radiotherapy. The main motivation is to use this statistical method to optimize the quality assurance processes in the validation of beam models. Considering the Varian Eclipse system, eight parameters with several levels were selected: energy, MLC, depth, X, Y 1 and Y 2 jaw dimensions, wedge and wedge jaw. A Taguchi table was used to define 72 validation tests. Measurements were conducted in water using a CC04 on a TrueBeam STx, a TrueBeam Tx, a Trilogy and a 2300IX accelerator matched by the vendor. Dose was computed using the AAA algorithm. The same raw data was used for all accelerators during the beam modelling. The mean difference between computed and measured doses was 0.1±0.5% for all beams and all accelerators with a maximum difference of 2.4% (under the 3% tolerance level). For all beams, the measured doses were within 0.6% for all accelerators. The energy was found to be an influencing parameter but the deviations observed were smaller than 1% and not considered clinically significant. Designs of experiment can help define the optimal measurement set to validate a beam model. The proposed method can be used to identify the prognostic factors of dose accuracy. The beam models were validated for the 4 accelerators which were found dosimetrically equivalent even though the accelerator characteristics differ. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  3. Development and Validation of Capabilities to Measure Thermal Properties of Layered Monolithic U-Mo Alloy Plate-Type Fuel

    Science.gov (United States)

    Burkes, Douglas E.; Casella, Andrew M.; Buck, Edgar C.; Casella, Amanda J.; Edwards, Matthew K.; MacFarlan, Paul J.; Pool, Karl N.; Smith, Frances N.; Steen, Franciska H.

    2014-07-01

    The uranium-molybdenum (U-Mo) alloy in a monolithic form has been proposed as one fuel design capable of converting some of the world's highest power research reactors from the use of high enriched uranium to low enriched uranium. One aspect of the fuel development and qualification process is to demonstrate appropriate understanding of the thermal-conductivity behavior of the fuel system as a function of temperature and expected irradiation conditions. The purpose of this paper is to verify functionality of equipment installed in hot cells for eventual measurements on irradiated uranium-molybdenum (U-Mo) monolithic fuel specimens, refine procedures to operate the equipment, and validate models to extract the desired thermal properties. The results presented here demonstrate the adequacy of the equipment, procedures, and models that have been developed for this purpose based on measurements conducted on surrogate depleted uranium-molybdenum (DU-Mo) alloy samples containing a Zr diffusion barrier and clad in aluminum alloy 6061 (AA6061). The results are in excellent agreement with thermal property data reported in the literature for similar U-Mo alloys as a function of temperature.

  4. STORMVEX: The Storm Peak Lab Cloud Property Validation Experiment Science and Operations Plan

    Energy Technology Data Exchange (ETDEWEB)

    Mace, J; Matrosov, S; Shupe, M; Lawson, P; Hallar, G; McCubbin, I; Marchand, R; Orr, B; Coulter, R; Sedlacek, A; Avallone, L; Long, C

    2010-09-29

    During the Storm Peak Lab Cloud Property Validation Experiment (STORMVEX), a substantial correlative data set of remote sensing observations and direct in situ measurements from fixed and airborne platforms will be created in a winter season, mountainous environment. This will be accomplished by combining mountaintop observations at Storm Peak Laboratory and the airborne National Science Foundation-supported Colorado Airborne Multi-Phase Cloud Study campaign with collocated measurements from the second ARM Mobile Facility (AMF2). We describe in this document the operational plans and motivating science for this experiment, which includes deployment of AMF2 to Steamboat Springs, Colorado. The intensive STORMVEX field phase will begin nominally on 1 November 2010 and extend to approximately early April 2011.

  5. A validation study of the psychometric properties of the Groningen Reflection Ability Scale

    DEFF Research Database (Denmark)

    Andersen, Nina Bjerre; O'Neill, Lotte; Gormsen, Lise Kirstine

    2014-01-01

    Background Reflection, the ability to examine critically one’s own learning and functioning, is considered important for ‘the good doctor’. The Groningen Reflection Ability Scale (GRAS) is an instrument measuring student reflection, which has not yet been validated beyond the original Dutch study....... The aim of this study was to adapt GRAS for use in a Danish setting and to investigate the psychometric properties of GRAS-DK. Methods We performed a cross-cultural adaptation of GRAS from Dutch to Danish. Next, we collected primary data online, performed a retest, analysed data descriptively, estimated...... measurement error, performed an exploratory and a confirmatory factor analysis to test the proposed three-factor structure. Results 361 (69%) of 523 invited students completed GRAS-DK. Their mean score was 88 (SD = 11.42; scale maximum 115). Scores were approximately normally distributed. Measurement error...

  6. Boiling points of halogenated aliphatic compounds: a quantitative structure-property relationship for prediction and validation.

    Science.gov (United States)

    Oberg, Tomas

    2004-01-01

    Halogenated aliphatic compounds have many technical uses, but substances within this group are also ubiquitous environmental pollutants that can affect the ozone layer and contribute to global warming. The establishment of quantitative structure-property relationships is of interest not only to fill in gaps in the available database but also to validate experimental data already acquired. The three-dimensional structures of 240 compounds were modeled with molecular mechanics prior to the generation of empirical descriptors. Two bilinear projection methods, principal component analysis (PCA) and partial-least-squares regression (PLSR), were used to identify outliers. PLSR was subsequently used to build a multivariate calibration model by extracting the latent variables that describe most of the covariation between the molecular structure and the boiling point. Boiling points were also estimated with an extension of the group contribution method of Stein and Brown.

  7. Human factors verification and validation of the advanced nuclear plant control room design

    International Nuclear Information System (INIS)

    Gutierrez, Richard; Zizzo, David; Yu, Kim

    2005-01-01

    The GE Advanced Boiling Water Reactor (ABWR) design has implemented the applicable human factors engineering (HFE) principles in the design of human-system interfaces (HSI). The ABWR uses unique features such as large mimic and touch-screen technology to present plant overviews and system operating details to the control room operating staff. The HSI designs, both in the console panels and the software generated graphical user interfaces, have been developed and evaluated using HFE guidelines. In addition to HFE guidelines reviews performed during design and implementation, broader reviews have been performed under the HFE Verification and Validation Implementation Plan (HFE V and VIP). Based upon the NUREG-0711, Nuclear Regulatory Commission (NRC) HFE Program Review Model (HFE PRM) (Reference 1), the HFE V and VIP, hereafter also referred to as V and V, has provided feedback during the various phases of design, implementation, and integration of the HSI. As one of the ten elements of the HFE PRM, the V and V activities reaffirm that the design of the HSI conforms to the HFE design principles and that the plant operating staff in the control room can perform their assigned tasks. This rigorous HFE V and V process is now being applied in the implementation of the ABWR design for Taiwan Power Company's Lungmen Power Station. Two 1350 MWe ABWR units are currently under construction at Lungmen. The HFE V and V ensures that the process for the design is compliant with the HFE principles. An important aspect of the Lungmen HFE program has been the direct involvement of the end user, Taiwan Power Company (TPC), throughout the design development and implementation. These HFE V and V activities, performed in three phases, ensures that the necessary displays, control, and alarms are provided to support the identified personnel tasks. The HFE V and V also checks to determine that the design of each identified component is compliant with the HFE principles. The V and V ensures

  8. A model-based design and validation approach with OMEGA-UML and the IF toolset

    Science.gov (United States)

    Ben-hafaiedh, Imene; Constant, Olivier; Graf, Susanne; Robbana, Riadh

    2009-03-01

    Intelligent, embedded systems such as autonomous robots and other industrial systems are becoming increasingly more heterogeneous with respect to the platforms on which they are implemented, and thus the software architecture more complex to design and analyse. In this context, it is important to have well-defined design methodologies which should be supported by (1) high level design concepts allowing to master the design complexity, (2) concepts for the expression of non-functional requirements and (3) analysis tools allowing to verify or invalidate that the system under development will be able to conform to its requirements. We illustrate here such an approach for the design of complex embedded systems on hand of a small case study used as a running example for illustration purposes. We briefly present the important concepts of the OMEGA-RT UML profile, we show how we use this profile in a modelling approach, and explain how these concepts are used in the IFx verification toolbox to integrate validation into the design flow and make scalable verification possible.

  9. Validity and psychometric properties of the General Health Questionnaire-12 in young Australian adolescents.

    Science.gov (United States)

    Tait, Robert J; French, Davina J; Hulse, Gary K

    2003-06-01

    The General Health Questionnaire (GHQ) is a measure of current mental wellbeing that has been extensively validated with adults. The instrument has also been used with adolescents. (i) To assess the psychometric properties of the GHQ-12 among school students in grades 7-10; (ii) to validate it against other psychological tests; and (iii) to suggest a threshold score. The survey was conducted in single sex and mixed schools from the state and private system in Perth, Western Australia. The survey contained the GHQ-12 and measures of anxiety, depression, self-esteem, stress, generalized self-efficacy, social desirability and negative affectivity. There were 336 students (female 55%) with an age range of 11-15 years (median 13). The GHQ showed good internal consistency (alpha 0.88). Girls had higher mean GHQ-12 scores than boys (F (1,326) 15.0, p school grade (F (3,326) 4.2, p < 0.01). Multiple linear regression showed that depression, anxiety, self-esteem and stress were significant independent predictors of GHQ scores. The model accounted for 68% of the variance (adjusted R 2). Screening indices were calculated by comparison with a combined depression and/or anxiety category. Threshold scores of 13/14 for males and 18/19 for females appeared optimal. General Health Questionnaire scores were compared with two criterion groups: adolescents in hospital with alcohol or drug (AOD) related problems and those with problems not related to AOD use. Only the former group had significantly higher total scores. The GHQ-12 showed good structural characteristics and was appropriately correlated with other measures of related traits. Overall, the GHQ-12 appears to be a valid index of psychological wellbeing in this population and was considerably shorter than some of the other instruments.

  10. The validity and psychometric properties of the Japanese version of the Compulsive Internet Use Scale (CIUS).

    Science.gov (United States)

    Yong, Roseline Kim Fong; Inoue, Akiomi; Kawakami, Norito

    2017-05-30

    Prolonged Internet use is often associated with reduced social involvement and comorbid psychopathologies, including depression, anxiety, attention-deficit/hyperactivity disorder, and obsessive-compulsive disorder. Asian countries where Internet access is widely available have high reported levels of Internet addiction. As Internet use has changed drastically since concerns about Internet addiction were first raised, the results of recent studies may be inaccurate because the scales they employed to measure Internet addiction were formulated for different Internet usage from the present. It is thus necessary to develop more-up-to-date scales to assess problematic private use of the Internet. The Compulsive Internet Use Scale (CIUS) was translated into Japanese. An online sample whose ages and sexes reflected that of the national population of Internet users was recruited to test the scale's reliability and validity. Correlations between the scale and Internet-related parameters (such as time spent online, motivation for going online, and applications used) and psychosocial factors (such as psychological distress symptoms and loneliness) were examined. Psychometric properties were examined by the split-half method using both exploratory and confirmatory factor analysis. Model fits were compared across gender. CIUS was found to have a high reliability and good concurrent, correlation and construct validity. Both exploratory and confirmatory factors revealed that the one-factor solution yielded a satisfactory result across gender. However, the three-factor structural model in which compulsiveness was gauged by "excessive absorption", "difficulty in setting priorities", and "mood regulation" gave the best fit of the model for the general population as well as across gender. Compulsive Internet behavior in Japan can be assessed in terms of absorption, priorities, and mood. CIUS is a valid scale for screening compulsive Internet behavior in the general Japanese

  11. Computer code validation study of PWR core design system, CASMO-3/MASTER-α

    International Nuclear Information System (INIS)

    Lee, K. H.; Kim, M. H.; Woo, S. W.

    1999-01-01

    In this paper, the feasibility of CASMO-3/MASTER-α nuclear design system was investigated for commercial PWR core. Validation calculation was performed as follows. Firstly, the accuracy of cross section generation from table set using linear feedback model was estimated. Secondly, the results of CASMO-3/MASTER-α was compared with CASMO-3/NESTLE 5.02 for a few benchmark problems. Microscopic cross sections computed from table set were almost the same with those from CASMO-3. There were small differences between calculated results of two code systems. Thirdly, the repetition of CASMO-3/MASTER-α calculation for Younggwang Unit-3, Cycle-1 core was done and their results were compared with nuclear design report(NDR) and uncertainty analysis results of KAERI. It was found that uncertainty analysis results were reliable enough because results were agreed each other. It was concluded that the use of nuclear design system CASMO-3/MASTER-α was validated for commercial PWR core

  12. The Space Technology-7 Disturbance Reduction System Precision Control Flight Validation Experiment Control System Design

    Science.gov (United States)

    O'Donnell, James R.; Hsu, Oscar C.; Maghami, Peirman G.; Markley, F. Landis

    2006-01-01

    As originally proposed, the Space Technology-7 Disturbance Reduction System (DRS) project, managed out of the Jet Propulsion Laboratory, was designed to validate technologies required for future missions such as the Laser Interferometer Space Antenna (LISA). The two technologies to be demonstrated by DRS were Gravitational Reference Sensors (GRSs) and Colloidal MicroNewton Thrusters (CMNTs). Control algorithms being designed by the Dynamic Control System (DCS) team at the Goddard Space Flight Center would control the spacecraft so that it flew about a freely-floating GRS test mass, keeping it centered within its housing. For programmatic reasons, the GRSs were descoped from DRS. The primary goals of the new mission are to validate the performance of the CMNTs and to demonstrate precise spacecraft position control. DRS will fly as a part of the European Space Agency (ESA) LISA Pathfinder (LPF) spacecraft along with a similar ESA experiment, the LISA Technology Package (LTP). With no GRS, the DCS attitude and drag-free control systems make use of the sensor being developed by ESA as a part of the LTP. The control system is designed to maintain the spacecraft s position with respect to the test mass, to within 10 nm/the square root of Hz over the DRS science frequency band of 1 to 30 mHz.

  13. Experimental validation of thermal design of top shield for a pool type SFR

    International Nuclear Information System (INIS)

    Aithal, Sriramachandra; Babu, V. Rajan; Balasubramaniyan, V.; Velusamy, K.; Chellapandi, P.

    2016-01-01

    Highlights: • Overall thermal design of top shield in a SFR is experimentally verified. • Air jet cooling is effective in ensuring the temperatures limits for top shield. • Convection patterns in narrow annulus are in line with published CFD results. • Wire mesh insulation ensures gradual thermal gradient at top portion of main vessel. • Under loss of cooling scenario, sufficient time is available for corrective action. - Abstract: An Integrated Top Shield Test Facility towards validation of thermal design of top shield for a pool type SFR has been conceived, constructed & commissioned. Detailed experiments were performed in this experimental facility having full-scale features. Steady state temperature distribution within the facility is measured for various heater plate temperatures in addition to simulating different operating states of the reactor. Following are the important observations (i) jet cooling system is effective in regulating the roof slab bottom plate temperature and thermal gradient across roof slab simulating normal operation of reactor, (ii) wire mesh insulation provided in roof slab-main vessel annulus is effective in obtaining gradual thermal gradient along main vessel top portion and inhibiting the setting up of cellular convection within annulus and (iii) cellular convection with four distinct convective cells sets in the annular gap between roof slab and small rotatable plug measuring ∼ϕ4 m in diameter & gap width varying from 16 mm to 30 mm. Repeatability of results is also ensured during all the above tests. The results presented in this paper is expected to provide reference data for validation of thermal hydraulic models in addition to serving as design validation of jet cooling system for pool type SFR.

  14. Sliding spool design for reducing the actuation forces in direct operated proportional directional valves: Experimental validation

    International Nuclear Information System (INIS)

    Amirante, Riccardo; Distaso, Elia; Tamburrano, Paolo

    2016-01-01

    Highlights: • An innovative procedure to design a commercial proportional directional valve is shown. • Experimental tests are performed to demonstrate the flow force reduction. • The design is improved by means of a previously made optimization procedure. • Great reduction in the flow forces without reducing the flow rate is demonstrated. - Abstract: This paper presents the experimental validation of a new methodology for the design of the spool surfaces of four way three position direct operated proportional directional valves. The proposed methodology is based on the re-design of both the compensation profile (the central conical surface of the spool) and the lateral surfaces of the spool, in order to reduce the flow forces acting on the spool and hence the actuation forces. The aim of this work is to extend the application range of these valves to higher values of pressure and flow rate, thus avoiding the employment of more expensive two stage configurations in the case of high-pressure conditions and/or flow rate. The paper first presents a theoretical approach and a general strategy for the sliding spool design to be applied to any four way three position direct operated proportional directional valve. Then, the proposed approach is experimentally validated on a commercially available valve using a hydraulic circuit capable of measuring the flow rate as well as the actuation force over the entire spool stroke. The experimental results, performed using both the electronic driver provided by the manufacturer and a manual actuation system, show that the novel spool surface requires remarkably lower actuation forces compared to the commercial configuration, while maintaining the same flow rate trend as a function of the spool position.

  15. Designing, Capturing and Validating History-Sensitive Security Policies for Distributed Systems

    DEFF Research Database (Denmark)

    Hernandez, Alejandro Mario; Nielson, Flemming; Nielson, Hanne Riis

    2011-01-01

    has the capability of combining both history-sensitive and future-sensitive policies, providing even more flexibility and power. Moreover, we propose a global Logic for reasoning about the systems designed with this language. We show how the Logic can be used to validate the combination of security...... this approach with history-based components, as is traditional in reference-monitor-based approaches to mandatory access control. Our developments are performed in an Aspect-oriented coordination language, aiming to describe the Bell-LaPadula policy as elegantly as possible. Furthermore, the resulting language...

  16. A Computer-Based Sustained Visual Attention Test for Pre-School Children: Design, Development and Psychometric Properties

    Directory of Open Access Journals (Sweden)

    Roohollah Zahedian Nasb

    2016-06-01

    Full Text Available Background: Sustained visual attention is a prerequisite for learning and memory. The early evaluation of attention in childhood is essential for their school and career success in the future. The aim of this study was to design, development and investigation of psychometric properties (content, face and convergent validity and test-retest and internal consistency reliability of the computer - based sustained visual attention test (SuVAT for healthy preschool children aged 4-6 with their special needs. Methods: This study was carried out in two stages: in the first stage computerbased SuVAT in two versions original and parallel were developed. Then the test-retest and internal consistency reliability using intra-class correlation and Cronbach’s alpha coefficients respectively were examined; Face validity was calculated through ideas gathering from 10 preschool children and content validity evaluated using CVI and CVR method and convergent validity of SuVAT with CPT was assessed using Pearson correlation. Results: The developed test showed a good content and faces validity, and also had excellent test-retest reliability. In addition, the assessment of internal consistency indicated the high internal consistency of the test (Cronbach’s alpha=0.869. SuVAT and CPT test demonstrated a positive correlation upon the convergent validity testing. Conclusion: SuVAT with good reliability and validity could be used as an acceptable sustained attention assessment in preschool children.

  17. Psychometric properties and construct validity of the Muscle Appearance Satisfaction Scale among Hungarian men.

    Science.gov (United States)

    Babusa, Bernadett; Urbán, Róbert; Czeglédi, Edit; Túry, Ferenc

    2012-01-01

    Limited studies have evaluated the psychometric properties of the Muscle Appearance Satisfaction Scale (MASS), a measure of muscle dysmorphia, in different cultures and languages. The aims were to examine the psychometric properties of the Hungarian version of the MASS (MASS-HU), and to investigate its relationship with self-esteem and exercise-related variables. Two independent samples of male weight lifters (ns=289 and 43), and a sample of undergraduates (n=240) completed the MASS, Eating Disorder Inventory, and Rosenberg Self-esteem Scale. Exploratory factor analysis supported the original five-factor structure of the MASS only in the weight lifter sample. The MASS-HU had excellent scale score reliability and good test-retest reliability. The construct validity of the MASS-HU was tested with multivariate regression analyses which indicated an inverse relationship between self-esteem and muscle dysmorphia. The 18-item MASS-HU was found to be a useful measure for the assessment of muscle dysmorphia among male weight lifters. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. The Design and Validation of the Colorado Learning Attitudes about Science Survey

    Science.gov (United States)

    Adams, W. K.; Perkins, K. K.; Dubson, M.; Finkelstein, N. D.; Wieman, C. E.

    2005-09-01

    The Colorado Learning Attitudes about Science Survey (CLASS) is a new instrument designed to measure various facets of student attitudes and beliefs about learning physics. This instrument extends previous work by probing additional facets of student attitudes and beliefs. It has been written to be suitably worded for students in a variety of different courses. This paper introduces the CLASS and its design and validation studies, which include analyzing results from over 2400 students, interviews and factor analyses. Methodology used to determine categories and how to analyze the robustness of categories for probing various facets of student learning are also described. This paper serves as the foundation for the results and conclusions from the analysis of our survey data.

  19. Flexible Design Research to validate communication in persons with dementia in advanced stages

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner

    2003-01-01

    . The method is an ethnographical process research using Atlas.ti as qualitative research software for the analysis and administration of transcribed data, and using physiological data to validate observational data in a case study design. In a flexible design both quantitative and qualitative data collection...... enable ways of communication adjusted to the person. The songs function to structure, motivate, stimulate, and regulate, and finally as means of enabling communication and dialogue. The research is trying to investigate if songs have regulative effects and to outline different levels of communication...... methods are used as a rich approach to understanding communication. The qualitative analysis is based on principles of grounded theory using selective, open, and axial coding techniques. The quantitative data is combined with time scales, sequence measures and event coding adding different perspectives...

  20. Structural Design of the DTU-ESA MM-Wave Validation Standard Antenna

    DEFF Research Database (Denmark)

    Branner, Kim; Berring, Peter; Markussen, Christen Malte

    2015-01-01

    A new specially designed antenna to be used for inter-comparisons and validation of antenna test facilities is under development in cooperation between DTU and TICRA under a contract from the European Space Agency. The antenna is designed to be extremely thermally and mechanically stable...... in the range of temperatures 20±5°C under arbitrary orientation in the gravity field. The antenna has a characteristic length of approximately 500mm. And in order to obtain very low measuring error, the allowable deformations of the reflector and feeds are down to 2.5μm. The antenna is modelled structurally...... is connected via a glued contact formulation in MSC.MARC. Because of the size and the complexity of the model a computer cluster is applied to solve the analyses. This paper describes the structural solution to meet these extremely strict stability requirements and the structural analyses done in order...

  1. Thermoelectric properties of currently available Au/Pt thermocouples related to the valid reference function

    Directory of Open Access Journals (Sweden)

    Edler F.

    2015-01-01

    Full Text Available Au/Pt thermocouples are considered to be an alternative to High Temperature Standard Platinum Resistance Thermometers (HTSPRTs for realizing temperatures according to the International Temperature Scale of 1990 (ITS-90 in the temperature range between aluminium (660.323 °C and silver (961.78 °C. The original aim of this work was to develop and to validate a new reference function for Au/Pt thermocouples which reflects the properties of presently commercially available Au and Pt wires. The thermoelectric properties of 16 Au/Pt thermocouples constructed at different National Metrological Institutes by using wires from different suppliers and 4 commercially available Au/Pt thermocouples were investigated. Most of them exhibit significant deviations from the current reference function of Au/Pt thermocouples caused by the poor performance of the Au-wires available. Thermoelectric homogeneity was investigated by measuring immersion profiles during freezes at the freezing point of silver and in liquid baths. The thermoelectric inhomogeneities were found to be one order of magnitude larger than those of Au/Pt thermocouples of the Standard Reference Material® (SRM® 1749. The improvement of the annealing procedure of the gold wires is a key process to achieve thermoelectric homogeneities in the order of only about (2–3 mK, sufficient to replace the impracticable HTSPRTs as interpolation instruments of the ITS-90. Comparison measurements of some of the Au/Pt thermocouples against a HTSPRT and an absolutely calibrated radiation thermometer were performed and exhibit agreements within the expanded measurement uncertainties. It has been found that the current reference function of Au/Pt thermocouples reflects adequately the thermoelectric properties of currently available Au/Pt thermocouples.

  2. Psychometric properties and structural validity of the short version of the personality beliefs questionnaire (PBQ-SF)

    OpenAIRE

    Manrique Hernández, Rubén Darío; Universidad San Buenaventura; Moratto Vasquez, Nadia Semenova; Universidad CES

    2015-01-01

    The Personality Belief Questionnaire- Short Form (PBQ-SF) is an assessment instrument of personality beliefs based on the cognitive theory that states that these are characterized by a specific pattern of dysfunctional thoughts. The objective of this study was to establish the psychometric properties and structural validity of the PBQ-SF questionnaire in Colombian adults from 18 to 35 years old. To carry out the above and with permission of the author the validation process was initiated foll...

  3. Examining the Internal Validity and Statistical Precision of the Comparative Interrupted Time Series Design by Comparison with a Randomized Experiment

    Science.gov (United States)

    St.Clair, Travis; Cook, Thomas D.; Hallberg, Kelly

    2014-01-01

    Although evaluators often use an interrupted time series (ITS) design to test hypotheses about program effects, there are few empirical tests of the design's validity. We take a randomized experiment on an educational topic and compare its effects to those from a comparative ITS (CITS) design that uses the same treatment group as the experiment…

  4. [Design and validation of the CSR-Hospital-SP scale to measure corporate social responsibility].

    Science.gov (United States)

    Mira, José Joaquín; Lorenzo, Susana; Navarro, Isabel; Pérez-Jover, Virtudes; Vitaller, Julián

    2013-01-01

    To design and validate a scale (CSR-Hospital-SP) to determine health professionals' views on the approach of management to corporate social responsibility (CSR) in their hospital. The literature was reviewed to identify the main CSR scales and select the dimensions to be evaluated. The initial version of the scale consisted of 25 items. A convenience sample of a minimum of 224 health professionals working in five public hospitals in five autonomous regions were invited to respond. Floor and ceiling effects, internal consistency, reliability, and construct validity were analyzed. A total of 233 health professionals responded. The CSR-Hospital-SP scale had 20 items grouped into four factors. The item-total correlation was higher than 0.30; all factor loadings were greater than 0.50; 59.57% of the variance was explained; Cronbach's alpha was 0.90; Spearman-Brown's coefficient was 0.82. The CSR-Hospital-SP scale is a tool designed for hospitals that implement accountability mechanisms and promote socially responsible management approaches. Copyright © 2012 SESPAS. Published by Elsevier Espana. All rights reserved.

  5. Final Design and Experimental Validation of the Thermal Performance of the LHC Lattice Cryostats

    International Nuclear Information System (INIS)

    Bourcey, N.; Capatina, O.; Parma, V.; Poncet, A.; Rohmig, P.; Serio, L.; Skoczen, B.; Tock, J.-P.; Williams, L. R.

    2004-01-01

    The recent commissioning and operation of the LHC String 2 have given a first experimental validation of the global thermal performance of the LHC lattice cryostat at nominal cryogenic conditions. The cryostat designed to minimize the heat inleak from ambient temperature, houses under vacuum and thermally protects the cold mass, which contains the LHC twin-aperture superconducting magnets operating at 1.9 K in superfluid helium. Mechanical components linking the cold mass to the vacuum vessel, such as support posts and insulation vacuum barriers are designed with efficient thermalisations for heat interception to minimise heat conduction. Heat inleak by radiation is reduced by employing multilayer insulation (MLI) wrapped around the cold mass and around an aluminium thermal shield cooled to about 60 K.Measurements of the total helium vaporization rate in String 2 gives, after substraction of supplementary heat loads and end effects, an estimate of the total thermal load to a standard LHC cell (107 m) including two Short Straight Sections and six dipole cryomagnets. Temperature sensors installed at critical locations provide a temperature mapping which allows validation of the calculated and estimated thermal performance of the cryostat components, including efficiency of the heat interceptions

  6. Final Design and Experimental Validation of the Thermal Performance of the LHC Lattice Cryostats

    Science.gov (United States)

    Bourcey, N.; Capatina, O.; Parma, V.; Poncet, A.; Rohmig, P.; Serio, L.; Skoczen, B.; Tock, J.-P.; Williams, L. R.

    2004-06-01

    The recent commissioning and operation of the LHC String 2 have given a first experimental validation of the global thermal performance of the LHC lattice cryostat at nominal cryogenic conditions. The cryostat designed to minimize the heat inleak from ambient temperature, houses under vacuum and thermally protects the cold mass, which contains the LHC twin-aperture superconducting magnets operating at 1.9 K in superfluid helium. Mechanical components linking the cold mass to the vacuum vessel, such as support posts and insulation vacuum barriers are designed with efficient thermalisations for heat interception to minimise heat conduction. Heat inleak by radiation is reduced by employing multilayer insulation (MLI) wrapped around the cold mass and around an aluminium thermal shield cooled to about 60 K. Measurements of the total helium vaporization rate in String 2 gives, after substraction of supplementary heat loads and end effects, an estimate of the total thermal load to a standard LHC cell (107 m) including two Short Straight Sections and six dipole cryomagnets. Temperature sensors installed at critical locations provide a temperature mapping which allows validation of the calculated and estimated thermal performance of the cryostat components, including efficiency of the heat interceptions.

  7. Directed Design of Experiments for Validating Probability of Detection Capability of NDE Systems (DOEPOD)

    Science.gov (United States)

    Generazio, Edward R.

    2015-01-01

    Directed Design of Experiments for Validating Probability of Detection Capability of NDE Systems (DOEPOD) Manual v.1.2 The capability of an inspection system is established by applications of various methodologies to determine the probability of detection (POD). One accepted metric of an adequate inspection system is that there is 95% confidence that the POD is greater than 90% (90/95 POD). Design of experiments for validating probability of detection capability of nondestructive evaluation (NDE) systems (DOEPOD) is a methodology that is implemented via software to serve as a diagnostic tool providing detailed analysis of POD test data, guidance on establishing data distribution requirements, and resolving test issues. DOEPOD demands utilization of observance of occurrences. The DOEPOD capability has been developed to provide an efficient and accurate methodology that yields observed POD and confidence bounds for both Hit-Miss or signal amplitude testing. DOEPOD does not assume prescribed POD logarithmic or similar functions with assumed adequacy over a wide range of flaw sizes and inspection system technologies, so that multi-parameter curve fitting or model optimization approaches to generate a POD curve are not required. DOEPOD applications for supporting inspector qualifications is included.

  8. Design, construction and validation of a Plasmodium vivax microarray for the transcriptome profiling of clinical isolates

    KAUST Repository

    Boopathi, Pon Arunachalam

    2016-10-09

    High density oligonucleotide microarrays have been used on Plasmodium vivax field isolates to estimate whole genome expression. However, no microarray platform has been experimentally optimized for studying the transcriptome of field isolates. In the present study, we adopted both bioinformatics and experimental testing approaches to select best optimized probes suitable for detecting parasite transcripts from field samples and included them in designing a custom 15K P. vivax microarray. This microarray has long oligonucleotide probes (60 mer) that were in-situ synthesized onto glass slides using Agilent SurePrint technology and has been developed into an 8X15K format (8 identical arrays on a single slide). Probes in this array were experimentally validated and represents 4180 P. vivax genes in sense orientation, of which 1219 genes have also probes in antisense orientation. Validation of the 15K array by using field samples (n =14) has shown 99% of parasite transcript detection from any of the samples. Correlation analysis between duplicate probes (n = 85) present in the arrays showed perfect correlation (r(2) = 0.98) indicating the reproducibility. Multiple probes representing the same gene exhibited similar kind of expression pattern across the samples (positive correlation, r >= 0.6). Comparison of hybridization data with the previous studies and quantitative real-time PCR experiments were performed to highlight the microarray validation procedure. This array is unique in its design, and results indicate that the array is sensitive and reproducible. Hence, this microarray could be a valuable functional genomics tool to generate reliable expression data from P. vivax field isolates. (C) 2016 Published by Elsevier B.V.

  9. Design, construction and validation of a Plasmodium vivax microarray for the transcriptome profiling of clinical isolates

    KAUST Repository

    Boopathi, Pon Arunachalam; Subudhi, Amit; Middha, Sheetal; Acharya, Jyoti; Mugasimangalam, Raja Chinnadurai; Kochar, Sanjay Kumar; Kochar, Dhanpat Kumar; Das, Ashis

    2016-01-01

    High density oligonucleotide microarrays have been used on Plasmodium vivax field isolates to estimate whole genome expression. However, no microarray platform has been experimentally optimized for studying the transcriptome of field isolates. In the present study, we adopted both bioinformatics and experimental testing approaches to select best optimized probes suitable for detecting parasite transcripts from field samples and included them in designing a custom 15K P. vivax microarray. This microarray has long oligonucleotide probes (60 mer) that were in-situ synthesized onto glass slides using Agilent SurePrint technology and has been developed into an 8X15K format (8 identical arrays on a single slide). Probes in this array were experimentally validated and represents 4180 P. vivax genes in sense orientation, of which 1219 genes have also probes in antisense orientation. Validation of the 15K array by using field samples (n =14) has shown 99% of parasite transcript detection from any of the samples. Correlation analysis between duplicate probes (n = 85) present in the arrays showed perfect correlation (r(2) = 0.98) indicating the reproducibility. Multiple probes representing the same gene exhibited similar kind of expression pattern across the samples (positive correlation, r >= 0.6). Comparison of hybridization data with the previous studies and quantitative real-time PCR experiments were performed to highlight the microarray validation procedure. This array is unique in its design, and results indicate that the array is sensitive and reproducible. Hence, this microarray could be a valuable functional genomics tool to generate reliable expression data from P. vivax field isolates. (C) 2016 Published by Elsevier B.V.

  10. Development and validation of natural circulation based systems for new WWER designs

    International Nuclear Information System (INIS)

    Kurakov, Y.A.; Dragunov, Y.G.; Podshibiakin, A.K.; Fil, N.S.; Logvinov, S.A.; Sitnik, Y.K.; Berkovich, V.M.; Taranov, G.S.

    2002-01-01

    Elaboration and introduction of NPP designs with improved technical and economic parameters are defined as an important element of the National Program of nuclear power development approved by the Russian Federation Government in 1998. This Program considers the designs of WWER-1000/V-392 and WWER-640/ V-407 power units as the priority projects of the new generation NPPs with increased safety. A number of passive systems based on natural circulation phenomena are used in V-392 and V-407 designs to prevent or mitigate severe accidents. Design basis, configuration and effect of some naturally driven systems of V-392 design sited at Novovoronezh are mainly reflected in the present paper. One of the most important mean for severe accident prevention in V-392 design is so called SPOT - passive heat removal system designed to remove core decay heat in case of station blackout (including failure of all diesel generators). This system extracts the steam from the steam generator, condenses it and returns water to steam generator by natural circulation. The SPOT heat exchangers are cooled by atmospheric air coming by natural circulation through a special direct action control gates which operate passively as well. Extensive experimental investigation of the different aspects of this system operation has been carried out to validate its functioning under real plant conditions. In particular, full-scale section of air heat exchanger-condenser has been tested with natural circulation steam, condensate and air paths modeled. The environment air temperature and steam pressure condensing were varied in the wide range, and the relevant experimental results are being discussed in this paper. The effect of wind velocity and direction to the containment is also checked by the experiments. (author)

  11. Using simulation to validate and optimize the design of a hybrid solar-GCHP system

    Energy Technology Data Exchange (ETDEWEB)

    Kummert, M.; Bernier, M. [Ecole Polytechnique, Montreal, PQ (Canada). Dept. de Genie Mecanique; Roy, M. [Martin Roy and Associates, Deux-Montagnes, PQ (Canada)

    2006-07-01

    A redevelopment project that involves the sustainable construction of 3 buildings with 187 affordable and environmentally sound housing units in a Montreal community was discussed. The HVAC system was part of the integrated design process that focused on reducing greenhouse gas emissions, potable water use, the production of waste water and the production of solid waste through retrofitting, reuse and waste diversion. Design options were limited by pre-existing equipment and funding opportunities. The design was also influenced by the building's management structure whereby financial benefits from the energy savings go to a non-profit, community-run utility company that will re-invest in new phases of the project. The project involved the installation of a hybrid solar geothermal heat pump system. The design was different from the usual approach because the solar thermal system was sized to provide domestic hot water but not to compensate the annual imbalance in the ground loads. It was noted that the average temperature in the ground will decrease with time, due to the imbalance. This presentation provided the results of detailed TRNSYS simulations that validated and optimized the design of the hybrid ground-coupled heating plant including solar thermal collectors in the 3 multi-unit buildings. The TRNSYS simulation used building loads that were calculated in an earlier stage of the design process with DOE-2. A global heat exchange coefficient for radiators and floor heating was estimated in order to use realistic temperature levels. An analysis of the long-term system performance of this unique design showed that on a yearly basis, 33 per cent of the total heating load can come from renewable energy sources. 18 refs., 2 tabs., 13 figs.

  12. Algorithm Design and Validation for Adaptive Nonlinear Control Enhancement (ADVANCE) Technology Development for Resilient Flight Control, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — SSCI proposes to develop and test a framework referred to as the ADVANCE (Algorithm Design and Validation for Adaptive Nonlinear Control Enhancement), within which...

  13. SmartWeld/SmartProcess - intelligent model based system for the design and validation of welding processes

    Energy Technology Data Exchange (ETDEWEB)

    Mitchner, J.

    1996-04-01

    Diagrams are presented on an intelligent model based system for the design and validation of welding processes. Key capabilities identified include `right the first time` manufacturing, continuous improvement, and on-line quality assurance.

  14. [Comparative analysis of child development screening tools designed and validated in Mexico].

    Science.gov (United States)

    Orcajo-Castelán, Rodrigo; Sidonio-Aguayo, Beatriz; Alcacio-Mendoza, Jorge Augusto; López-Díaz, Giovana Lucía

    In recent years a number of child development screening tools have been developed in Mexico; however, their properties have not been compared. The objective of this review was to compare the report quality and risk bias of the screening tools developed and validated in Mexico in their published versions. A search was conducted in databases, gray literature and cross references. The resultant tests were compared and analyzed using STARD, QUADAS and QUADAS-2 criteria. "Valoración Neuroconductual del Desarrollo del Lactante" (VANEDELA), "Evaluación del Desarrollo Infantil or EDI" (CDE in English), "Prueba de Tamiz del Neurodesarrollo infantil" (PTNI), "Cartillas de Vigilancia para identificar alteraciones en el Desarrollo del Lactante" (CVDL) and "Indicadores de riesgo del Perfil de Conductas de Desarrollo" (INDIPCD-R) were included for the comparison. No test fulfilled all STARD items. The most complete in their methodological description were VANEDELA and EDI. The areas lacking more data on the reports were recruiting and patient selection (VANEDELA, PTNI, CVDL, INDIPCD-R). In QUADAS evaluation, all had some risk bias, but some serious concerns of risk bias were raised by patient sampling and by the choice of gold standard in two tests (PTNI, INDIPCD-R). Child development screening tests created and validated in Mexico have variable report quality and risk bias. The test with the best validation report quality is VANEDELA and the one with the lowest risk of bias is EDI. Copyright © 2015 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  15. Design and validation of an MR-conditional robot for transcranial focused ultrasound surgery in infants

    Energy Technology Data Exchange (ETDEWEB)

    Price, Karl D., E-mail: karl.price@sickkids.ca [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); The Department of Mechanical Engineering, The University of Toronto, Toronto, Ontario M5S 3G8 (Canada); Sin, Vivian W. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); Mougenot, Charles [Philips Healthcare Canada, Markham, Ontario L6C 2S3 (Canada); Pichardo, Samuel [Electrical Engineering, Lakehead University, Thunder Bay, Ontario P7B 5E1 (Canada); Looi, Thomas [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9 (Canada); Waspe, Adam C. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); Department of Medical Imaging, The University of Toronto, Toronto, Ontario M5T 1W7 (Canada); Drake, James M. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, Ontario M5G 1X8 (Canada); Department of Neurosurgery, The University of Toronto, Toronto, Ontario M5S 1A1 (Canada); The Institute of Biomaterials and Biomedical Engineering, The University of Toronto, Toronto, Ontario M5G 3G9 (Canada)

    2016-09-15

    Purpose: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed “incision-less surgery.” Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements. A novel robotic system is proposed to position a focused ultrasound transducer accurately above the head of a neonatal patient inside an MRI machine to deliver the therapy. Methods: A clinical Philips Sonalleve MRgFUS system was expanded to perform transcranial treatment. A five degree-of-freedom MR-conditional robot was designed and manufactured using MR compatible materials. The robot electronics and control were integrated into existing Philips electronics and software interfaces. The user commands the position of the robot with a graphical user interface, and is presented with real-time MR imaging of the patient throughout the surgery. The robot is validated through a series of experiments that characterize accuracy, signal-to-noise ratio degeneration of an MR image as a result of the robot, MR imaging artifacts generated by the robot, and the robot’s ability to operate in a representative surgical environment inside an MR machine. Results: Experimental results show the robot responds reliably within an MR environment, has achieved 0.59 ± 0.25 mm accuracy, does not produce severe MR-imaging artifacts, has a workspace providing sufficient coverage of a neonatal brain, and can manipulate a 5 kg payload. A full system demonstration shows these characteristics apply in an application environment. Conclusions: This paper presents a comprehensive look at the process of designing and validating a new robot from concept to implementation for use in an MR environment. An MR

  16. Design and validation of an MR-conditional robot for transcranial focused ultrasound surgery in infants

    International Nuclear Information System (INIS)

    Price, Karl D.; Sin, Vivian W.; Mougenot, Charles; Pichardo, Samuel; Looi, Thomas; Waspe, Adam C.; Drake, James M.

    2016-01-01

    Purpose: Current treatment of intraventricular hemorrhage (IVH) involves cerebral shunt placement or an invasive brain surgery. Magnetic resonance-guided focused ultrasound (MRgFUS) applied to the brains of pediatric patients presents an opportunity to treat IVH in a noninvasive manner, termed “incision-less surgery.” Current clinical and research focused ultrasound systems lack the capability to perform neonatal transcranial surgeries due to either range of motion or dexterity requirements. A novel robotic system is proposed to position a focused ultrasound transducer accurately above the head of a neonatal patient inside an MRI machine to deliver the therapy. Methods: A clinical Philips Sonalleve MRgFUS system was expanded to perform transcranial treatment. A five degree-of-freedom MR-conditional robot was designed and manufactured using MR compatible materials. The robot electronics and control were integrated into existing Philips electronics and software interfaces. The user commands the position of the robot with a graphical user interface, and is presented with real-time MR imaging of the patient throughout the surgery. The robot is validated through a series of experiments that characterize accuracy, signal-to-noise ratio degeneration of an MR image as a result of the robot, MR imaging artifacts generated by the robot, and the robot’s ability to operate in a representative surgical environment inside an MR machine. Results: Experimental results show the robot responds reliably within an MR environment, has achieved 0.59 ± 0.25 mm accuracy, does not produce severe MR-imaging artifacts, has a workspace providing sufficient coverage of a neonatal brain, and can manipulate a 5 kg payload. A full system demonstration shows these characteristics apply in an application environment. Conclusions: This paper presents a comprehensive look at the process of designing and validating a new robot from concept to implementation for use in an MR environment. An MR

  17. Design and experimental validation of Unilateral Linear Halbach magnet arrays for single-sided magnetic resonance.

    Science.gov (United States)

    Bashyam, Ashvin; Li, Matthew; Cima, Michael J

    2018-07-01

    Single-sided NMR has the potential for broad utility and has found applications in healthcare, materials analysis, food quality assurance, and the oil and gas industry. These sensors require a remote, strong, uniform magnetic field to perform high sensitivity measurements. We demonstrate a new permanent magnet geometry, the Unilateral Linear Halbach, that combines design principles from "sweet-spot" and linear Halbach magnets to achieve this goal through more efficient use of magnetic flux. We perform sensitivity analysis using numerical simulations to produce a framework for Unilateral Linear Halbach design and assess tradeoffs between design parameters. Additionally, the use of hundreds of small, discrete magnets within the assembly allows for a tunable design, improved robustness to variability in magnetization strength, and increased safety during construction. Experimental validation using a prototype magnet shows close agreement with the simulated magnetic field. The Unilateral Linear Halbach magnet increases the sensitivity, portability, and versatility of single-sided NMR. Copyright © 2018 Elsevier Inc. All rights reserved.

  18. Design and validation of a slender guideway for Maglev vehicle by simulation and experiment

    Science.gov (United States)

    Han, Jong-Boo; Han, Hyung-Suk; Kim, Sung-Soo; Yang, Seok-Jo; Kim, Ki-Jung

    2016-03-01

    Normally, Maglev (magnetic levitation) vehicles run on elevated guideways. The elevated guideway must satisfy various load conditions of the vehicle, and has to be designed to ensure ride quality, while ensuring that the levitation stability of the vehicle is not affected by the deflection of the guideway. However, because the elevated guideways of Maglev vehicles in South Korea and other countries fabricated so far have been based on over-conservative design criteria, the size of the structures has increased. Further, from the cost perspective, they are unfavourable when compared with other light rail transits such as monorail, rubber wheel, and steel wheel automatic guided transit. Therefore, a slender guideway that does have an adverse effect on the levitation stability of the vehicle is required through optimisation of design criteria. In this study, to predict the effect of various design parameters of the guideway on the dynamic behaviour of the vehicle, simulations were carried out using a dynamics model similar to the actual vehicle and guideway, and a limiting value of deflection ratio of the slender guideway to ensure levitation control is proposed. A guideway that meets the requirement as per the proposed limit for deflection ratio was designed and fabricated, and through a driving test of the vehicle, the validity of the slender guideway was verified. From the results, it was confirmed that although some increase in airgap and cabin acceleration was observed with the proposed slender guideway when compared with the conventional guideway, there was no notable adverse effect on the levitation stability and ride quality of the vehicle. Therefore, it can be inferred that the results of this study will become the basis for establishing design criteria for slender guideways of Maglev vehicles in future.

  19. Design of a Hydro-Turbine Blade for Acoustic and Performance Validation Studies

    Science.gov (United States)

    Johnson, E.; Barone, M.

    2011-12-01

    To meet the growing, global energy demands governments and industry have recently begun to focus on marine hydrokinetic (MHK) devices as an additional form of power generation. Water turbines have become a popular design choice since they are able to leverage experience from the decades-old wind industry in the hope of decreasing time-to-market. However, the difference in environments poses challenges that need to be addressed. In particular, little research has addressed the acoustic effects of common aerofoils in a marine setting. This has both a potential impact on marine life and may cause early fatigue by exciting new structural modes. An initial blade design is presented, which has been used to begin characterization of any structural and acoustic issues that may arise from a direct one-to-one swap of wind technologies into MHK devices. The blade was optimized for performance using blade-element momentum theory while requiring that it not exceed the allowable stress under a specified extreme operating design condition. This limited the maximum power generated, while ensuring a realizable blade. A stress analysis within ANSYS was performed to validate the structural integrity of the design. Additionally, predictions of the radiated noise from the MHK rotor will be made using boundary element modeling based on flow results from ANSYS CFX, a computational fluid dynamics (CFD) code. The FEA and CFD results demonstrate good comparison to the expected design. Determining a range for the anticipated noise produced from a MHK turbine provides a look at the environmental impact these devices will have. Future efforts will focus on the design constraints noise generation places on MHK devices.

  20. Thermal enhancement cartridge heater modified tritium hydride bed development, Part 2 - Experimental validation of key conceptual design features

    Energy Technology Data Exchange (ETDEWEB)

    Heroux, K.J.; Morgan, G.A. [Savannah River Laboratory, Aiken, SC (United States)

    2015-03-15

    The Thermal Enhancement Cartridge Heater Modified (TECH Mod) tritium hydride bed is an interim replacement for the first generation (Gen1) process hydride beds currently in service in the Savannah River Site (SRS) Tritium Facilities. 3 new features are implemented in the TECH Mod hydride bed prototype: internal electric cartridge heaters, porous divider plates, and copper foam discs. These modifications will enhance bed performance and reduce costs by improving bed activation and installation processes, in-bed accountability measurements, end-of-life bed removal, and He-3 recovery. A full-scale hydride bed test station was constructed at the Savannah River National Laboratory (SRNL) in order to evaluate the performance of the prototype TECH Mod hydride bed. Controlled hydrogen (H{sub 2}) absorption/ desorption experiments were conducted to validate that the conceptual design changes have no adverse effects on the gas transfer kinetics or H{sub 2} storage/release properties compared to those of the Gen1 bed. Inert gas expansions before, during, and after H{sub 2} flow tests were used to monitor changes in gas transfer rates with repeated hydriding/de-hydriding of the hydride material. The gas flow rates significantly decreased after initial hydriding of the material; however, minimal changes were observed after repeated cycling. The data presented herein confirm that the TECH Mod hydride bed would be a suitable replacement for the Gen1 bed with the added enhancements expected from the advanced design features. (authors)

  1. Experimental validation of a numerical 3-D finite model applied to wind turbines design under vibration constraints: TREVISE platform

    Science.gov (United States)

    Sellami, Takwa; Jelassi, Sana; Darcherif, Abdel Moumen; Berriri, Hanen; Mimouni, Med Faouzi

    2018-04-01

    With the advancement of wind turbines towards complex structures, the requirement of trusty structural models has become more apparent. Hence, the vibration characteristics of the wind turbine components, like the blades and the tower, have to be extracted under vibration constraints. Although extracting the modal properties of blades is a simple task, calculating precise modal data for the whole wind turbine coupled to its tower/foundation is still a perplexing task. In this framework, this paper focuses on the investigation of the structural modeling approach of modern commercial micro-turbines. Thus, the structural model a complex designed wind turbine, which is Rutland 504, is established based on both experimental and numerical methods. A three-dimensional (3-D) numerical model of the structure was set up based on the finite volume method (FVM) using the academic finite element analysis software ANSYS. To validate the created model, experimental vibration tests were carried out using the vibration test system of TREVISE platform at ECAM-EPMI. The tests were based on the experimental modal analysis (EMA) technique, which is one of the most efficient techniques for identifying structures parameters. Indeed, the poles and residues of the frequency response functions (FRF), between input and output spectra, were calculated to extract the mode shapes and the natural frequencies of the structure. Based on the obtained modal parameters, the numerical designed model was up-dated.

  2. Design, construction and validation of a portable care system for the daily telerehabiliatation of gait.

    Science.gov (United States)

    Giansanti, Daniele; Morelli, Sandra; Maccioni, Giovanni; Brocco, Monica

    2013-10-01

    When designing a complete system of daily-telerehabilitation it should be borne in mind that properly designed methodologies should be furnished for patients to execute specific motion tasks and for care givers to assess the relevant parameters. Whether in hospital or at home, the system should feature two basic elements: (a) instrumented and walking aids or supports, (b) equipment for the assessment of parameters. Being gait the focus, the idea was to design, construct and validate - as an alternative to the complex and expensive instruments currently used - a simple, portable kit that may be easily interfaced/integrated with the most common mechanical tools used in motion rehabilitation (instrumented walkways, aids, supports), with feedback to both patient for self-monitoring and trainer/therapist (present or remote) for clinical reporting. The proposed system consists of: one step-counter, three couples of photo-emitter detectors, one central unit for collecting and processing the telemetrically transmitted data; a software interface on a dedicated PC and a network adapter. The system has been successfully validated in a clinical application on two groups of 16 subjects at the 1st and 2nd level of the Tinetti test. The degree of acceptance by subjects and care-givers was high. The system was also successfully compared with an Inertial Measurement Unit, a de facto standard. The portable kit can be used with different rehabilitation tools and different ground rugosity. The advantages are: (a) very low costs when compared with optoelectronic solutions and other portable solutions; (b) very high accuracy, also for subjects with imbalance problems; (c) good compatibility with any rehabilitative tool. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  3. LOX/hydrocarbon rocket engine analytical design methodology development and validation. Volume 2: Appendices

    Science.gov (United States)

    Niiya, Karen E.; Walker, Richard E.; Pieper, Jerry L.; Nguyen, Thong V.

    1993-05-01

    This final report includes a discussion of the work accomplished during the period from Dec. 1988 through Nov. 1991. The objective of the program was to assemble existing performance and combustion stability models into a usable design methodology capable of designing and analyzing high-performance and stable LOX/hydrocarbon booster engines. The methodology was then used to design a validation engine. The capabilities and validity of the methodology were demonstrated using this engine in an extensive hot fire test program. The engine used LOX/RP-1 propellants and was tested over a range of mixture ratios, chamber pressures, and acoustic damping device configurations. This volume contains time domain and frequency domain stability plots which indicate the pressure perturbation amplitudes and frequencies from approximately 30 tests of a 50K thrust rocket engine using LOX/RP-1 propellants over a range of chamber pressures from 240 to 1750 psia with mixture ratios of from 1.2 to 7.5. The data is from test configurations which used both bitune and monotune acoustic cavities and from tests with no acoustic cavities. The engine had a length of 14 inches and a contraction ratio of 2.0 using a 7.68 inch diameter injector. The data was taken from both stable and unstable tests. All combustion instabilities were spontaneous in the first tangential mode. Although stability bombs were used and generated overpressures of approximately 20 percent, no tests were driven unstable by the bombs. The stability instrumentation included six high-frequency Kistler transducers in the combustion chamber, a high-frequency Kistler transducer in each propellant manifold, and tri-axial accelerometers. Performance data is presented, both characteristic velocity efficiencies and energy release efficiencies, for those tests of sufficient duration to record steady state values.

  4. Development and validation of a radial turbine efficiency and mass flow model at design and off-design conditions

    International Nuclear Information System (INIS)

    Serrano, José Ramón; Arnau, Francisco José; García-Cuevas, Luis Miguel; Dombrovsky, Artem; Tartoussi, Hadi

    2016-01-01

    Highlights: • A procedure for performance maps extrapolation of any radial turbine is presented. • Non measured VGT positions, speeds and blade to jet speed ratios can be extrapolated. • Calibration coefficients that can be fitted with a limited set of map data are used. • Experimental points at high blade to jet speed ratios have been used for validation. • The extrapolation accuracy is good in different map ranges and variables. - Abstract: Turbine performance at extreme off-design conditions is growing in importance for properly computing turbocharged reciprocating internal combustion engines behaviour during urban driving conditions at current and future homologation cycles. In these cases, the turbine operates at very low flow rates and power outputs and at very high blade to jet speed ratios during transitory periods due to turbocharger wheel inertia and the high pulsation level of engine exhaust flow. This paper presents a physically based method that is able to extrapolate radial turbines reduced mass flow and adiabatic efficiency in blade speed ratio, turbine rotational speed and stator vanes position. The model uses a very narrow range of experimental data from turbine maps to fit the necessary coefficients. By using a special experimental turbocharger gas stand, experimental data have been obtained for extremely low turbine power outputs for the sake of model validation. Even if the data used for fitting only covers the turbine normal operation zone, the extrapolation model provides very good agreement with the experiments at very high blade speed ratio points; producing also good results when extrapolating in rotational speed and stator vanes position.

  5. Rational design of soft mechanical metamaterials : Independent tailoring of elastic properties with randomness

    NARCIS (Netherlands)

    Mirzaali Mazandarani, M.J.; Hedayati, R.; Vena, P; Vergani, L.; Strano, M.; Zadpoor, A.A.

    2017-01-01

    The elastic properties of mechanical metamaterials are direct functions of their topological designs. Rational design approaches based on computational models could, therefore, be used to devise topological designs that result in the desired properties. It is of particular importance to

  6. Design and validation of a CT-guided robotic system for lung cancer brachytherapy.

    Science.gov (United States)

    Dou, Huaisu; Jiang, Shan; Yang, Zhiyong; Sun, Luqing; Ma, Xiaodong; Huo, Bin

    2017-09-01

    Currently, lung brachytherapy in clinical setting is a complex procedure. Operation accuracy depends on accurate positioning of the template; however, it is difficult to guarantee the positioning accuracy manually. Application of robotic-assisted systems can simplify the procedure and improve the manual positioning accuracy. Therefore, a novel CT-guided robotic system was developed to assist the lung cancer brachytherapy. A four degree-of-freedom (DOF) robot, controlled by a lung brachytherapy treatment planning system (TPS) software, was designed and manufactured to assist the template positioning. Target position of the template can be obtained from the treatment plan, thus the robot is driven to the target position automatically. The robotic system was validated in both the laboratory and the CT environment. In laboratory environment, a 3D laser tracker and an inertial measurement unit (IMU) were used to measure the mechanical accuracy in air, which includes positioning accuracy and position repeatability. Working reliability was also validated in this procedure by observing the response reliability and calculating the position repeatability. Imaging artifacts and accuracy of the robot registration were validated in the CT environment by using an artificial phantom with fiducial markers. CT images were obtained and used to test the image artifact and calculate the registration accuracy. Phantom experiments were conducted to test the accuracy of needle insertion by using a transparent hydrogel phantom with a high imitation artificial phantom. Also, the efficiency was validated in this procedure by comparing time costs in manual positioning with robotic positioning under the same experimental conditions. The robotic system achieved the positioning accuracy of 0.28 ± 0.25 mm and the position repeatability of 0.09 ± 0.11 mm. Experimental results showed that the robot was CT-compatible and responded reliably to the control commands. The mean registration accuracy

  7. Design, Development & Functional Validation of Magnets system in support of 42 GHz Gyrotron in India

    Directory of Open Access Journals (Sweden)

    Pradhan S.

    2017-01-01

    Full Text Available A multi institutional initiative is underway towards the development of 42 GHz, 200 kW gyrotron system in India under the frame work of Department of Science and Technology, Government of India. Indigenous realization comprising of design, fabrication, prototypes and functional validations of an appropriate Magnet System is one of the primary technological objective of these initiatives. The 42 GHz gyrotron magnet system comprises of a warm gun magnet, a NbTi/Cu based high homogenous superconducting cavity magnet and three warm collector magnets. The superconducting cavity magnet has been housed inside a low loss cryostat. The magnet system has been designed in accordance with gyrotron physics and engineering considerations respecting highly homogenous spatial field profile as well as maintaining steep gradient as per the compression and velocity ratios between the emission and resonator regions. The designed magnet system further ensures the co-linearity of the magnetic axis with that of the beam axis with custom winding techniques apart from a smooth collection of beam with the collector magnet profiles. The designed magnets have been wound after several R & D validations. The superconducting magnet has been housed inside a low loss designed cryostat with in-built radial and axial alignment flexibilities to certain extent. The cryostat further houses liquid helium port, liquid nitrogen ports, current communication ports, ports for monitoring helium level and other instrumentations apart from over-pressure safety intensive burst disks etc. The entire magnet system comprising of warm and superconducting magnets has been installed and integrated in the Gyrotron test set-up. The magnet system has been aligned in both warm and when the superconducting cavity magnet is cold. The integrated geometric axes have been experimentally ensured as well as the field profiles have been measured with the magnets being charged. Under experimental conditions

  8. The Stick Design Test on the assessment of older adults with low formal education: evidences of construct, criterion-related and ecological validity.

    Science.gov (United States)

    de Paula, Jonas Jardim; Costa, Mônica Vieira; Bocardi, Matheus Bortolosso; Cortezzi, Mariana; De Moraes, Edgar Nunes; Malloy-Diniz, Leandro Fernandes

    2013-12-01

    The assessment of visuospatial abilities is usually performed by drawing tasks. In patients with very low formal education, the use of these tasks might be biased by their cultural background. The Stick Design Test was developed for the assessment of this population. We aim to expand the test psychometric properties by assessing its construct, criterion-related and ecological validity in older adults with low formal education. Healthy older adults (n = 63) and Alzheimer's disease patients (n = 92) performed the Stick Design Test, Mini-Mental State Examination, Digit Span Forward and the Clock Drawing Test. Their caregivers answered Personal Care and Instrumental Activities of Daily Living). Construct validity was assessed by factor analysis, convergent correlations (with the Clock Drawing Test), and divergent correlations (with Digit Span Forward); criterion-related validity by receiver operating characteristic curve analysis and binary logistic regression; and Ecological validity by correlations with ADL. The test factor structure was composed by one component (R 2 = 64%). Significant correlations with the Clock Drawing Test and Digit Span Forward were found, and the relationship was stronger with the first measure. The test was less associated with formal education than the Clock Drawing Test. It classified about 76% of the participants correctly and had and additive effect with the Mini-Mental State Examination (84% of correct classification). The test also correlated significantly with measures of ADL, suggesting ecological validity. The Stick Design Test shows evidence of construct, criterion-related and ecological validity. It is an interesting alternative to drawing tasks for the assessment of visuospatial abilities.

  9. CFD validation of a supercritical water flow for SCWR design heat and mass fluxes

    International Nuclear Information System (INIS)

    Roelofs, F.; Lycklama a Nijeholt, J.A.; Komen, E.M.J.; Lowenberg, M.; Starflinger, J.

    2007-01-01

    The applicability of Computational Fluid Dynamics (CFD) for water under supercritical conditions in supercritical water reactors (SCWR) has still to be verified. In the recent past, CFD validation analyses were performed by various institutes for supercritical water in vertical tubes based on the well known experimental data from Yamagata. However, validation using data from experiments with working conditions closer to the actual operational conditions of such reactors is needed. From a literature survey the experiments performed by Herkenrath are selected to perform validation analyses at higher heat fluxes and a higher mass flux. The accuracy of CFD using RANS (Reynolds Average Navier-Stokes) turbulence modelling for supercritical fluids under conditions close to the operational conditions of a supercritical water reactor is determined. It is concluded that the wall temperature can be predicted by RANS CFD, using the RNG k-ε turbulence model, with accuracy in the range of 5% for heat fluxes up to 1100 kW/m 2 and for a bulk enthalpy up to 2200 kJ/kg. For a bulk enthalpy exceeding 2200 kJ/kg, a significant lower accuracy of the CFD predictions (about 3%) is found for the simulations of the experiments of Yamagata in comparison with the simulations of the experiments of Herkenrath. For these experiments, the accuracy is about 18 per cent. This might be a result of the fact that the CFD analyses do not simulate the flattening of the temperature profile at about 2200 kJ/kg which is found in the experiments of Herkenrath. However, the obtained accuracies ranging from 3% to 18% are still deemed to be acceptable for many design purposes. (authors)

  10. Design, validation, and use of an evaluation instrument for monitoring systemic reform

    Science.gov (United States)

    Scantlebury, Kathryn; Boone, William; Butler Kahle, Jane; Fraser, Barry J.

    2001-08-01

    Over the past decade, state and national policymakers have promoted systemic reform as a way to achieve high-quality science education for all students. However, few instruments are available to measure changes in key dimensions relevant to systemic reform such as teaching practices, student attitudes, or home and peer support. Furthermore, Rasch methods of analysis are needed to permit valid comparison of different cohorts of students during different years of a reform effort. This article describes the design, development, validation, and use of an instrument that measures student attitudes and several environment dimensions (standards-based teaching, home support, and peer support) using a three-step process that incorporated expert opinion, factor analysis, and item response theory. The instrument was validated with over 8,000 science and mathematics students, taught by more than 1,000 teachers in over 200 schools as part of a comprehensive assessment of the effectiveness of Ohio's systemic reform initiative. When the new four-factor, 20-item questionnaire was used to explore the relative influence of the class, home, and peer environment on student achievement and attitudes, findings were remarkably consistent across 3 years and different units and methods of analysis. All three environments accounted for unique variance in student attitudes, but only the environment of the class accounted for unique variance in student achievement. However, the class environment (standards-based teaching practices) was the strongest independent predictor of both achievement and attitude, and appreciable amounts of the total variance in attitudes were common to the three environments.

  11. Effect of Uncertainties in Physical Property Estimates on Process Design - Sensitivity Analysis

    DEFF Research Database (Denmark)

    Hukkerikar, Amol; Jones, Mark Nicholas; Sin, Gürkan

    for performing sensitivity of process design subject to uncertainties in the property estimates. To this end, first uncertainty analysis of the property models of pure components and their mixtures was performed in order to obtain the uncertainties in the estimated property values. As a next step, sensitivity......Chemical process design calculations require accurate and reliable physical and thermodynamic property data and property models of pure components and their mixtures in order to obtain reliable design parameters which help to achieve desired specifications. The uncertainties in the property values...... can arise from the experiments itself or from the property models employed. It is important to consider the effect of these uncertainties on the process design in order to assess the quality and reliability of the final design. The main objective of this work is to develop a systematic methodology...

  12. Theoretical modeling and experimental validation of transport and separation properties of carbon nanotube electrospun membrane distillation

    KAUST Repository

    Lee, Jung Gil; Lee, Eui-Jong; Jeong, Sanghyun; Guo, Jiaxin; An, Alicia Kyoungjin; Guo, Hong; Kim, Joonha; Leiknes, TorOve; Ghaffour, NorEddine

    2016-01-01

    Developing a high flux and selective membrane is required to make membrane distillation (MD) a more attractive desalination process. Amongst other characteristics membrane hydrophobicity is significantly important to get high vapor transport and low wettability. In this study, a laboratory fabricated carbon nanotubes (CNTs) composite electrospun (E-CNT) membrane was tested and has showed a higher permeate flux compared to poly(vinylidene fluoride-co-hexafluoropropylene) (PH) electrospun membrane (E-PH membrane) in a direct contact MD (DCMD) configuration. Only 1% and 2% of CNTs incorporation resulted in an enhanced permeate flux with lower sensitivity to feed salinity while treating a 35 and 70 g/L NaCl solutions. Experimental results and the mechanisms of E-CNT membrane were validated by a proposed new step-modeling approach. The increased vapor transport in E-CNT membranes could not be elucidated by an enhancement of mass transfer only at a given physico-chemical properties. However, the theoretical modeling approach considering the heat and mass transfers simultaneously enabled to explain successfully the enhanced flux in the DCMD process using E-CNT membranes. This indicates that both mass and heat transfers improved by CNTs are attributed to the enhanced vapor transport in the E-CNT membrane.

  13. Theoretical modeling and experimental validation of transport and separation properties of carbon nanotube electrospun membrane distillation

    KAUST Repository

    Lee, Jung Gil

    2016-12-27

    Developing a high flux and selective membrane is required to make membrane distillation (MD) a more attractive desalination process. Amongst other characteristics membrane hydrophobicity is significantly important to get high vapor transport and low wettability. In this study, a laboratory fabricated carbon nanotubes (CNTs) composite electrospun (E-CNT) membrane was tested and has showed a higher permeate flux compared to poly(vinylidene fluoride-co-hexafluoropropylene) (PH) electrospun membrane (E-PH membrane) in a direct contact MD (DCMD) configuration. Only 1% and 2% of CNTs incorporation resulted in an enhanced permeate flux with lower sensitivity to feed salinity while treating a 35 and 70 g/L NaCl solutions. Experimental results and the mechanisms of E-CNT membrane were validated by a proposed new step-modeling approach. The increased vapor transport in E-CNT membranes could not be elucidated by an enhancement of mass transfer only at a given physico-chemical properties. However, the theoretical modeling approach considering the heat and mass transfers simultaneously enabled to explain successfully the enhanced flux in the DCMD process using E-CNT membranes. This indicates that both mass and heat transfers improved by CNTs are attributed to the enhanced vapor transport in the E-CNT membrane.

  14. Design and experimental validation for direct-drive fault-tolerant permanent-magnet vernier machines.

    Science.gov (United States)

    Liu, Guohai; Yang, Junqin; Chen, Ming; Chen, Qian

    2014-01-01

    A fault-tolerant permanent-magnet vernier (FT-PMV) machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs). This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM), the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis.

  15. Design and validation of a GNC system for missions to asteroids: the AIM scenario

    Science.gov (United States)

    Pellacani, A.; Kicman, P.; Suatoni, M.; Casasco, M.; Gil, J.; Carnelli, I.

    2017-12-01

    Deep space missions, and in particular missions to asteroids, impose a certain level of autonomy that depends on the mission objectives. If the mission requires the spacecraft to perform close approaches to the target body (the extreme case being a landing scenario), the autonomy level must be increased to guarantee the fast and reactive response which is required in both nominal and contingency operations. The GNC system must be designed in accordance with the required level of autonomy. The GNC system designed and tested in the frame of ESA's Asteroid Impact Mission (AIM) system studies (Phase A/B1 and Consolidation Phase) is an example of an autonomous GNC system that meets the challenging objectives of AIM. The paper reports the design of such GNC system and its validation through a DDVV plan that includes Model-in-the-Loop and Hardware-in-the-Loop testing. Main focus is the translational navigation, which is able to provide online the relative state estimation with respect to the target body using exclusively cameras as relative navigation sensors. The relative navigation outputs are meant to be used for nominal spacecraft trajectory corrections as well as to estimate the collision risk with the asteroid and, if needed, to command the execution of a collision avoidance manoeuvre to guarantee spacecraft safety

  16. Design and Experimental Validation for Direct-Drive Fault-Tolerant Permanent-Magnet Vernier Machines

    Directory of Open Access Journals (Sweden)

    Guohai Liu

    2014-01-01

    Full Text Available A fault-tolerant permanent-magnet vernier (FT-PMV machine is designed for direct-drive applications, incorporating the merits of high torque density and high reliability. Based on the so-called magnetic gearing effect, PMV machines have the ability of high torque density by introducing the flux-modulation poles (FMPs. This paper investigates the fault-tolerant characteristic of PMV machines and provides a design method, which is able to not only meet the fault-tolerant requirements but also keep the ability of high torque density. The operation principle of the proposed machine has been analyzed. The design process and optimization are presented specifically, such as the combination of slots and poles, the winding distribution, and the dimensions of PMs and teeth. By using the time-stepping finite element method (TS-FEM, the machine performances are evaluated. Finally, the FT-PMV machine is manufactured, and the experimental results are presented to validate the theoretical analysis.

  17. Design and Validation of Real-Time PCR: Quantitative Diagnosis of Common Leishmania Species in Iran.

    Science.gov (United States)

    Fekri Soofi Abadi, Maryam; Dabiri, Shahriar; Fotouhi Ardakani, Reza; Fani Malaki, Lina; Amirpoor Rostami, Sahar; Ziasistani, Mahsa; Dabiri, Donya

    2016-07-01

    Design and validation of Real-time PCR on the protected gene region ITS2 to quantify the parasite load in common leishmania (L) species. Probe and primer were designed from the ITS2 region between the rRNA genes with minimum gene variation in three common leishmania species followed by a Real-time PCR using the Taq man probe method in the form of absolute quantification. A series of different concentrations of leishmania were analyzed. After the purified PCR product was successfully placed in a PTG19-T plasmid vector, specialized ITS2 region was cloned in this plasmid. In the last phase, the cloned gene was transferred to the Ecoli.Top10F bacteria. The standard plasmid was provided in 10(7) to 10(1) copies/rxn concentrations. The specification and clinical sensitivity of the data was analyzed using inter and intra scales. The probe and primer were designed using three species, including L. infantum, L. major, and L.tropica. Seven concentrations of purified parasite in culture media showed that the selected region for quantifying the parasite is suitable. Clinical and analytical specificity and sensitivity were both 100%, respectively. The Taq man method for the ITS2 region in leishmania is one the most sensitive diagnostic test for identifying the parasite load and is suggested as a tool for fast identification and quantification of species.

  18. Design and Validation of an Augmented Reality System for Laparoscopic Surgery in a Real Environment

    Science.gov (United States)

    López-Mir, F.; Naranjo, V.; Fuertes, J. J.; Alcañiz, M.; Bueno, J.; Pareja, E.

    2013-01-01

    Purpose. This work presents the protocol carried out in the development and validation of an augmented reality system which was installed in an operating theatre to help surgeons with trocar placement during laparoscopic surgery. The purpose of this validation is to demonstrate the improvements that this system can provide to the field of medicine, particularly surgery. Method. Two experiments that were noninvasive for both the patient and the surgeon were designed. In one of these experiments the augmented reality system was used, the other one was the control experiment, and the system was not used. The type of operation selected for all cases was a cholecystectomy due to the low degree of complexity and complications before, during, and after the surgery. The technique used in the placement of trocars was the French technique, but the results can be extrapolated to any other technique and operation. Results and Conclusion. Four clinicians and ninety-six measurements obtained of twenty-four patients (randomly assigned in each experiment) were involved in these experiments. The final results show an improvement in accuracy and variability of 33% and 63%, respectively, in comparison to traditional methods, demonstrating that the use of an augmented reality system offers advantages for trocar placement in laparoscopic surgery. PMID:24236293

  19. Validation of RetroPath, a computer-aided design tool for metabolic pathway engineering.

    Science.gov (United States)

    Fehér, Tamás; Planson, Anne-Gaëlle; Carbonell, Pablo; Fernández-Castané, Alfred; Grigoras, Ioana; Dariy, Ekaterina; Perret, Alain; Faulon, Jean-Loup

    2014-11-01

    Metabolic engineering has succeeded in biosynthesis of numerous commodity or high value compounds. However, the choice of pathways and enzymes used for production was many times made ad hoc, or required expert knowledge of the specific biochemical reactions. In order to rationalize the process of engineering producer strains, we developed the computer-aided design (CAD) tool RetroPath that explores and enumerates metabolic pathways connecting the endogenous metabolites of a chassis cell to the target compound. To experimentally validate our tool, we constructed 12 top-ranked enzyme combinations producing the flavonoid pinocembrin, four of which displayed significant yields. Namely, our tool queried the enzymes found in metabolic databases based on their annotated and predicted activities. Next, it ranked pathways based on the predicted efficiency of the available enzymes, the toxicity of the intermediate metabolites and the calculated maximum product flux. To implement the top-ranking pathway, our procedure narrowed down a list of nine million possible enzyme combinations to 12, a number easily assembled and tested. One round of metabolic network optimization based on RetroPath output further increased pinocembrin titers 17-fold. In total, 12 out of the 13 enzymes tested in this work displayed a relative performance that was in accordance with its predicted score. These results validate the ranking function of our CAD tool, and open the way to its utilization in the biosynthesis of novel compounds. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Design and Validation of an Augmented Reality System for Laparoscopic Surgery in a Real Environment

    Directory of Open Access Journals (Sweden)

    F. López-Mir

    2013-01-01

    Full Text Available Purpose. This work presents the protocol carried out in the development and validation of an augmented reality system which was installed in an operating theatre to help surgeons with trocar placement during laparoscopic surgery. The purpose of this validation is to demonstrate the improvements that this system can provide to the field of medicine, particularly surgery. Method. Two experiments that were noninvasive for both the patient and the surgeon were designed. In one of these experiments the augmented reality system was used, the other one was the control experiment, and the system was not used. The type of operation selected for all cases was a cholecystectomy due to the low degree of complexity and complications before, during, and after the surgery. The technique used in the placement of trocars was the French technique, but the results can be extrapolated to any other technique and operation. Results and Conclusion. Four clinicians and ninety-six measurements obtained of twenty-four patients (randomly assigned in each experiment were involved in these experiments. The final results show an improvement in accuracy and variability of 33% and 63%, respectively, in comparison to traditional methods, demonstrating that the use of an augmented reality system offers advantages for trocar placement in laparoscopic surgery.

  1. [Gender-determinant factors in contraception: design and validation of a questionnaire].

    Science.gov (United States)

    Yago Simón, Teresa; Tomás Aznar, Concepción

    2013-10-01

    To design and validate a questionnaire for young women on gender-determinant factors in contraception. A questionnaire was developed from conversations with young women attending contraception clinic in the Health Promotion Municpal Centre, Zaragoza. A total of 200 young women between the ages of 13 and 24 self-completed the questionnaire, with only one no response. Several items were analysed: reliability, using Cronbach's alpha coefficient, and construct validity by analysis of the main components with eigenvalues above 1, and Quartimax rotation with Kaiser normalisation. The questionnaire contained 36 items and took 10minutes to self-complete. There was good internal consistency, with a Cronbach's alpha 0,853. Twelve factors were established with an explanation of 61.42% variance, and three descriptive lines: relationship dimension («submissive attitude», «blind attitude», «let go due to affection», «dominant partner»), gender identity («maternity as identity», «non-idealised maternity», «traditional role», «insecurity», «shame») and caring. This questionnaire enabled gender determinant-factors that take part in contraception to be identified, and will be useful to find out how the different ways of relating between the sexes influence the problems of sexual and reproductive health in young women in our environment. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  2. Structure-function-property-design interplay in biopolymers: spider silk.

    Science.gov (United States)

    Tokareva, Olena; Jacobsen, Matthew; Buehler, Markus; Wong, Joyce; Kaplan, David L

    2014-04-01

    Spider silks have been a focus of research for almost two decades due to their outstanding mechanical and biophysical properties. Recent advances in genetic engineering have led to the synthesis of recombinant spider silks, thus helping to unravel a fundamental understanding of structure-function-property relationships. The relationships between molecular composition, secondary structures and mechanical properties found in different types of spider silks are described, along with a discussion of artificial spinning of these proteins and their bioapplications, including the role of silks in biomineralization and fabrication of biomaterials with controlled properties. Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  3. Optimal Design and Model Validation for Combustion Experiments in a Shock Tube

    KAUST Repository

    Long, Quan

    2014-01-06

    We develop a Bayesian framework for the optimal experimental design of the shock tube experiments which are being carried out at the KAUST Clean Combustion Center. The unknown parameters are the pre-exponential parameters and the activation energies in the reaction rate functions. The control parameters are the initial hydrogen concentration and the temperature. First, we build a polynomial based surrogate model for the observable related to the reactions in the shock tube. Second, we use a novel MAP based approach to estimate the expected information gain in the proposed experiments and select the best experimental set-ups corresponding to the optimal expected information gains. Third, we use the synthetic data to carry out virtual validation of our methodology.

  4. Validation of the CORD-2 System for the Nuclear Design Calculations of the NPP Krsko Core

    International Nuclear Information System (INIS)

    Kromar, M.; Kurincic, B.

    2016-01-01

    The CORD-2 package intended for core design calculations of PWRs has be recently updated with some improved models. Since the modifications could substantially influence the obtained results, a technical validation process is required. This paper presents comparison of some calculated and measured parameters of the NPP Krsko core needed to qualify the package. Critical boron concentrations at hot full power for selected cycle burnup points and several parameters obtained during the start-up testing at the beginning of each cycle (hot zero power critical concentration, isothermal temperature coefficient and rods worth) for all 27 finished cycles of operation are considered. In addition, assembly-wise power distribution for some selected cycles is checked. Comparison has shown very good agreement of the CORD-2 calculated values with the selected measured parameter of the NPP Krsko core.(author).

  5. A mobile sensing system for structural health monitoring: design and validation

    International Nuclear Information System (INIS)

    Zhu, Dapeng; Yi, Xiaohua; Wang, Yang; Lee, Kok-Meng; Guo, Jiajie

    2010-01-01

    This paper describes a new approach using mobile sensor networks for structural health monitoring. Compared with static sensors, mobile sensor networks offer flexible system architectures with adaptive spatial resolutions. The paper first describes the design of a mobile sensing node that is capable of maneuvering on structures built with ferromagnetic materials. The mobile sensing node can also attach/detach an accelerometer onto/from the structural surface. The performance of the prototype mobile sensor network has been validated through laboratory experiments. Two mobile sensing nodes are adopted for navigating on a steel portal frame and providing dense acceleration measurements. Transmissibility function analysis is conducted to identify structural damage using data collected by the mobile sensing nodes. This preliminary work is expected to spawn transformative changes in the use of mobile sensors for future structural health monitoring

  6. Final Report, Validation of Novel Planar Cell Design for MW-Scale SOFC Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Swartz, Dr Scott L.; Thrun, Dr Lora B.; Arkenberg, Mr Gene B.; Chenault, Ms Kellie M.

    2012-01-03

    This report describes the work completed by NexTech Materials, Ltd. during a three-year project to validate an electrolyte-supported planar solid oxide fuel cell design, termed the FlexCell, for coal-based, megawatt-scale power generation systems. This project was focused on the fabrication and testing of electrolyte-supported FlexCells with yttria-stabilized zirconia (YSZ) as the electrolyte material. YSZ based FlexCells were made with sizes ranging from 100 to 500 cm2. Single-cell testing was performed to confirm high electrochemical performance, both with diluted hydrogen and simulated coal gas as fuels. Finite element analysis modeling was performed at The Ohio State University was performed to establish FlexCell architectures with optimum mechanical robustness. A manufacturing cost analysis was completed, which confirmed that manufacturing costs of less than $50/kW are achievable at high volumes (500 MW/year).

  7. Validation of Novel Planar Cell Design for MW-Scale SOFC Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Scott Swartz; Lora Thrun; Gene Arkenberg; Kellie Chenault

    2011-09-30

    This report describes the work completed by NexTech Materials, Ltd. during a three-year project to validate an electrolyte-supported planar solid oxide fuel cell design, termed the FlexCell, for coal-based, megawatt-scale power generation systems. This project was focused on the fabrication and testing of electrolyte-supported FlexCells with yttria-stabilized zirconia (YSZ) as the electrolyte material. YSZ based FlexCells were made with sizes ranging from 100 to 500 cm{sup 2}. Single-cell testing was performed to confirm high electrochemical performance, both with diluted hydrogen and simulated coal gas as fuels. Finite element analysis modeling was performed at The Ohio State University was performed to establish FlexCell architectures with optimum mechanical robustness. A manufacturing cost analysis was completed, which confirmed that manufacturing costs of less than $50/kW are achievable at high volumes (500 MW/year). DISCLAIMER

  8. Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability

    Energy Technology Data Exchange (ETDEWEB)

    McCarthy, J.F.; Halbrook, R.S.; Shugart, L.R.

    1991-12-01

    This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a user's guide'' that lays out a logical scheme for applying biomarkers in environmental monitoring. In addition, laboratory and field research components needed to develop and validate fundamental understanding and interpretation of biomarker responses are also described, as is a strategy for evolution of a biomarker-based biomonitoring capability. The document is divided into sections intended to lead the reader to an understanding of how biomarkers can be developed and applied.

  9. Conceptual strategy for design, implementation, and validation of a biomarker-based biomonitoring capability

    Energy Technology Data Exchange (ETDEWEB)

    McCarthy, J.F.; Halbrook, R.S.; Shugart, L.R.

    1991-12-01

    This document describes a strategy for defining specific objectives for biomarker studies and for designing and implementing a biomonitoring study that focuses on these objectives. In researching this subject, it became clear to the authors that the subject of biomarkers created a great deal of interest among scientists and regulators but that general acceptance of biomarkers as a tool for environmental protection was hampered by lack of a clear notion of how to develop and apply this approach. We intend this document to be a ``user`s guide`` that lays out a logical scheme for applying biomarkers in environmental monitoring. In addition, laboratory and field research components needed to develop and validate fundamental understanding and interpretation of biomarker responses are also described, as is a strategy for evolution of a biomarker-based biomonitoring capability. The document is divided into sections intended to lead the reader to an understanding of how biomarkers can be developed and applied.

  10. A mobile sensing system for structural health monitoring: design and validation

    Science.gov (United States)

    Zhu, Dapeng; Yi, Xiaohua; Wang, Yang; Lee, Kok-Meng; Guo, Jiajie

    2010-05-01

    This paper describes a new approach using mobile sensor networks for structural health monitoring. Compared with static sensors, mobile sensor networks offer flexible system architectures with adaptive spatial resolutions. The paper first describes the design of a mobile sensing node that is capable of maneuvering on structures built with ferromagnetic materials. The mobile sensing node can also attach/detach an accelerometer onto/from the structural surface. The performance of the prototype mobile sensor network has been validated through laboratory experiments. Two mobile sensing nodes are adopted for navigating on a steel portal frame and providing dense acceleration measurements. Transmissibility function analysis is conducted to identify structural damage using data collected by the mobile sensing nodes. This preliminary work is expected to spawn transformative changes in the use of mobile sensors for future structural health monitoring.

  11. Design and Validation of Control Room Upgrades Using a Research Simulator Facility

    Energy Technology Data Exchange (ETDEWEB)

    Ronald L. Boring; Vivek Agarwal; Jeffrey C. Joe; Julius J. Persensky

    2012-11-01

    Since 1981, the United States (U.S.) Nuclear Regulatory Commission (NRC) [1] requires a plant- specific simulator facility for use in training at U.S. nuclear power plants (NPPs). These training simulators are in near constant use for training and qualification of licensed NPP operators. In the early 1980s, the Halden Man-Machine Laboratory (HAMMLab) at the Halden Reactor Project (HRP) in Norway first built perhaps the most well known set of research simulators. The HRP offered a high- fidelity simulator facility in which the simulator is functionally linked to a specific plant but in which the human-machine interface (HMI) may differ from that found in the plant. As such, HAMMLab incorporated more advanced digital instrumentation and controls (I&C) than the plant, thereby giving it considerable interface flexibility that researchers took full advantage of when designing and validating different ways to upgrade NPP control rooms. Several U.S. partners—the U.S. NRC, the Electrical Power Research Institute (EPRI), Sandia National Laboratories, and Idaho National Laboratory (INL) – as well as international members of the HRP, have been working with HRP to run control room simulator studies. These studies, which use crews from Scandinavian plants, are used to determine crew behavior in a variety of normal and off-normal plant operations. The findings have ultimately been used to guide safety considerations at plants and to inform advanced HMI design—both for the regulator and in industry. Given the desire to use U.S. crews of licensed operators on a simulator of a U.S. NPP, there is a clear need for a research simulator facility in the U.S. There is no general-purpose reconfigurable research oriented control room simulator facility in the U.S. that can be used for a variety of studies, including the design and validation of control room upgrades.

  12. Design and validation of a microfluidic device for blood-brain barrier monitoring and transport studies

    Science.gov (United States)

    Ugolini, Giovanni Stefano; Occhetta, Paola; Saccani, Alessandra; Re, Francesca; Krol, Silke; Rasponi, Marco; Redaelli, Alberto

    2018-04-01

    In vitro blood-brain barrier models are highly relevant for drug screening and drug development studies, due to the challenging task of understanding the transport mechanism of drug molecules through the blood-brain barrier towards the brain tissue. In this respect, microfluidics holds potential for providing microsystems that require low amounts of cells and reagent and can be potentially multiplexed for increasing the ease and throughput of the drug screening process. We here describe the design, development and validation of a microfluidic device for endothelial blood-brain barrier cell transport studies. The device comprises of two microstructured layers (top culture chamber and bottom collection chamber) sandwiching a porous membrane for the cell culture. Microstructured layers include two pairs of physical electrodes, embedded into the device layers by geometrically defined guiding channels with computationally optimized positions. These electrodes allow the use of commercial electrical measurement systems for monitoring trans-endothelial electrical resistance (TEER). We employed the designed device for performing preliminary assessment of endothelial barrier formation with murine brain endothelial cells (Br-bEnd5). Results demonstrate that cellular junctional complexes effectively form in the cultures (expression of VE-Cadherin and ZO-1) and that the TEER monitoring systems effectively detects an increase of resistance of the cultured cell layers indicative of tight junction formation. Finally, we validate the use of the described microsystem for drug transport studies demonstrating that Br-bEnd5 cells significantly hinder the transport of molecules (40 kDa and 4 kDa dextran) from the top culture chamber to the bottom collection chamber.

  13. Design, validation and annotation of transcriptome-wide oligonucleotide probes for the oligochaete annelid Eisenia fetida.

    Directory of Open Access Journals (Sweden)

    Ping Gong

    Full Text Available High density oligonucleotide probe arrays have increasingly become an important tool in genomics studies. In organisms with incomplete genome sequence, one strategy for oligo probe design is to reduce the number of unique probes that target every non-redundant transcript through bioinformatic analysis and experimental testing. Here we adopted this strategy in making oligo probes for the earthworm Eisenia fetida, a species for which we have sequenced transcriptome-scale expressed sequence tags (ESTs. Our objectives were to identify unique transcripts as targets, to select an optimal and non-redundant oligo probe for each of these target ESTs, and to annotate the selected target sequences. We developed a streamlined and easy-to-follow approach to the design, validation and annotation of species-specific array probes. Four 244K-formatted oligo arrays were designed using eArray and were hybridized to a pooled E. fetida cRNA sample. We identified 63,541 probes with unsaturated signal intensities consistently above the background level. Target transcripts of these probes were annotated using several sequence alignment algorithms. Significant hits were obtained for 37,439 (59% probed targets. We validated and made publicly available 63.5K oligo probes so the earthworm research community can use them to pursue ecological, toxicological, and other functional genomics questions. Our approach is efficient, cost-effective and robust because it (1 does not require a major genomics core facility; (2 allows new probes to be easily added and old probes modified or eliminated when new sequence information becomes available, (3 is not bioinformatics-intensive upfront but does provide opportunities for more in-depth annotation of biological functions for target genes; and (4 if desired, EST orthologs to the UniGene clusters of a reference genome can be identified and selected in order to improve the target gene specificity of designed probes. This approach is

  14. Design, synthesis and physical properties of poly(styrene ...

    Indian Academy of Sciences (India)

    Administrator

    tance in the commodity plastics field because of their advantages as balanced properties and cost-effectiveness. ... Polymers and polymer-based materials with electro- conductive properties are materials with potential appli- ... BIO-RAD (4 cm–1 resolution). The number and weight- average molecular weight (Mn and Mw) ...

  15. The correlation of in vivo and ex vivo tissue dielectric properties to validate electromagnetic breast imaging: initial clinical experience

    International Nuclear Information System (INIS)

    Halter, Ryan J; Zhou, Tian; Meaney, Paul M; Hartov, Alex; Barth, Richard J Jr; Rosenkranz, Kari M; Wells, Wendy A; Kogel, Christine A; Borsic, Andrea; Rizzo, Elizabeth J; Paulsen, Keith D

    2009-01-01

    Electromagnetic (EM) breast imaging provides low-cost, safe and potentially a more specific modality for cancer detection than conventional imaging systems. A primary difficulty in validating these EM imaging modalities is that the true dielectric property values of the particular breast being imaged are not readily available on an individual subject basis. Here, we describe our initial experience in seeking to correlate tomographic EM imaging studies with discrete point spectroscopy measurements of the dielectric properties of breast tissue. The protocol we have developed involves measurement of in vivo tissue properties during partial and full mastectomy procedures in the operating room (OR) followed by ex vivo tissue property recordings in the same locations in the excised tissue specimens in the pathology laboratory immediately after resection. We have successfully applied all of the elements of this validation protocol in a series of six women with cancer diagnoses. Conductivity and permittivity gauged from ex vivo samples over the frequency range 100 Hz–8.5 GHz are found to be similar to those reported in the literature. A decrease in both conductivity and permittivity is observed when these properties are gauged from ex vivo samples instead of in vivo. We present these results in addition to a case study demonstrating how discrete point spectroscopy measurements of the tissue can be correlated and used to validate EM imaging studies

  16. Preliminary design of a small air loop for system analysis and validation of Cathare code

    International Nuclear Information System (INIS)

    Marchand, M.; Saez, M.; Tauveron, N.; Tenchine, D.; Germain, T.; Geffraye, G.; Ruby, G.P.

    2007-01-01

    The French Atomic Energy Commission (Cea) is carrying on the design of a Small Air Loop for System Analysis (SALSA), devoted to the study of gas cooled nuclear reactors behaviour in normal and incidental/accidental operating conditions. The reduced size of the SALSA components compared to a full-scale reactor and air as gaseous coolant instead of Helium will allow an easy management of the loop. The main purpose of SALSA will be the validation of the associated thermal hydraulic safety simulation codes, like CATHARE. The main goal of this paper is to present the methodology used to define the characteristics of the loop. In a first step, the study has been focused on a direct-cycle system for the SALSA loop with few global constraints using a similarity analysis to support the definition and design of the loop. Similarity requirements have been evaluated to determine the scale factors which have to be applied to the SALSA loop components. The preliminary conceptual design of the SALSA plant with a definition of each component has then be carried out. The whole plant has been modelled using the CATHARE code. Calculations of the SALSA steady-state in nominal conditions and of different plant transients in direct-cycle have been made. The first system results obtained on the global behaviour of the loop confirm that SALSA can be representative of a Gas-Cooled nuclear reactor with some minor design modifications. In a second step, the current prospects focus on the SALSA loop capability to reproduce correctly the heat transfer occurring in specific incidental situations. Heat decay removal by natural convection is a crucial point of interest. The first results show that the behaviour and the efficiency of the loop are strongly influenced by the definition of the main parameters for each component. A complete definition of SALSA is under progress. (authors)

  17. Integrating Materials, Manufacturing, Design and Validation for Sustainability in Future Transport Systems

    Science.gov (United States)

    Price, M. A.; Murphy, A.; Butterfield, J.; McCool, R.; Fleck, R.

    2011-05-01

    The predictive methods currently used for material specification, component design and the development of manufacturing processes, need to evolve beyond the current `metal centric' state of the art, if advanced composites are to realise their potential in delivering sustainable transport solutions. There are however, significant technical challenges associated with this process. Deteriorating environmental, political, economic and social conditions across the globe have resulted in unprecedented pressures to improve the operational efficiency of the manufacturing sector generally and to change perceptions regarding the environmental credentials of transport systems in particular. There is a need to apply new technologies and develop new capabilities to ensure commercial sustainability in the face of twenty first century economic and climatic conditions as well as transport market demands. A major technology gap exists between design, analysis and manufacturing processes in both the OEMs, and the smaller companies that make up the SME based supply chain. As regulatory requirements align with environmental needs, manufacturers are increasingly responsible for the broader lifecycle aspects of vehicle performance. These include not only manufacture and supply but disposal and re-use or re-cycling. In order to make advances in the reduction of emissions coupled with improved economic efficiency through the provision of advanced lightweight vehicles, four key challenges are identified as follows: Material systems, Manufacturing systems, Integrated design methods using digital manufacturing tools and Validation systems. This paper presents a project which has been designed to address these four key issues, using at its core, a digital framework for the creation and management of key parameters related to the lifecycle performance of thermoplastic composite parts and structures. It aims to provide capability for the proposition, definition, evaluation and demonstration of

  18. Integrating Materials, Manufacturing, Design and Validation for Sustainability in Future Transport Systems

    International Nuclear Information System (INIS)

    Price, M. A.; Murphy, A.; Butterfield, J.; McCool, R.; Fleck, R.

    2011-01-01

    The predictive methods currently used for material specification, component design and the development of manufacturing processes, need to evolve beyond the current 'metal centric' state of the art, if advanced composites are to realise their potential in delivering sustainable transport solutions. There are however, significant technical challenges associated with this process. Deteriorating environmental, political, economic and social conditions across the globe have resulted in unprecedented pressures to improve the operational efficiency of the manufacturing sector generally and to change perceptions regarding the environmental credentials of transport systems in particular. There is a need to apply new technologies and develop new capabilities to ensure commercial sustainability in the face of twenty first century economic and climatic conditions as well as transport market demands. A major technology gap exists between design, analysis and manufacturing processes in both the OEMs, and the smaller companies that make up the SME based supply chain. As regulatory requirements align with environmental needs, manufacturers are increasingly responsible for the broader lifecycle aspects of vehicle performance. These include not only manufacture and supply but disposal and re-use or re-cycling. In order to make advances in the reduction of emissions coupled with improved economic efficiency through the provision of advanced lightweight vehicles, four key challenges are identified as follows: Material systems, Manufacturing systems, Integrated design methods using digital manufacturing tools and Validation systems. This paper presents a project which has been designed to address these four key issues, using at its core, a digital framework for the creation and management of key parameters related to the lifecycle performance of thermoplastic composite parts and structures. It aims to provide capability for the proposition, definition, evaluation and demonstration of

  19. Experiment designs offered for discussion preliminary to an LLNL field scale validation experiment in the Yucca Mountain Exploratory Shaft Facility

    International Nuclear Information System (INIS)

    Lowry, B.; Keller, C.

    1988-01-01

    It has been proposed (''Progress Report on Experiment Rationale for Validation of LLNL Models of Ground Water Behavior Near Nuclear Waste Canisters,'' Keller and Lowry, Dec. 7, 1988) that a heat generating spent fuel canister emplaced in unsaturated tuff, in a ventilated hole, will cause a net flux of water into the borehole during the heating cycle of the spent fuel. Accompanying this mass flux will be the formation of mineral deposits near the borehole wall as the water evaporates and leaves behind its dissolved solids. The net effect of this process upon the containment of radioactive wastes is a function of (1) where and how much solid material is deposited in the tuff matrix and cracks, and (2) the resultant effect on the medium flow characteristics. Experimental concepts described in this report are designed to quantify the magnitude and relative location of solid mineral deposit formation due to a heated and vented borehole environment. The most simple tests address matrix effects only; after the process is understood in the homogeneous matrix, fracture effects would be investigated. Three experiment concepts have been proposed. Each has unique advantages and allows investigation of specific aspects of the precipitate formation process. All could be done in reasonable time (less than a year) and none of them are extremely expensive (the most expensive is probably the structurally loaded block test). The calculational ability exists to analyze the ''real'' situation and each of the experiment designs, and produce a credible series of tests. None of the designs requires the acquisition of material property data beyond current capabilities. The tests could be extended, if our understanding is consistent with the data produced, to analyze fracture effects. 7 figs

  20. Eutectics as improved pharmaceutical materials: design, properties and characterization.

    Science.gov (United States)

    Cherukuvada, Suryanarayan; Nangia, Ashwini

    2014-01-28

    Eutectics are a long known class of multi-component solids with important and useful applications in daily life. In comparison to other multi-component crystalline solids, such as salts, solid solutions, molecular complexes and cocrystals, eutectics are less studied in terms of molecular structure organization and bonding interactions. Classically, a eutectic is defined based on its low melting point compared to the individual components. In this article, we attempt to define eutectics not just based on thermal methods but from a structural organization view point, and discuss their microstructures and properties as organic materials vis-a-vis solid solutions and cocrystals. The X-ray crystal structure of a cocrystal is different from that of the individual components whereas the unit cell of a solid solution is similar to that of one of the components. Eutectics are closer to the latter species in that their crystalline arrangement is similar to the parent components but they are different with respect to the structural integrity. A solid solution possesses structural homogeneity throughout the structure (single phase) but a eutectic is a heterogeneous ensemble of individual components whose crystal structures are like discontinuous solid solutions (phase separated). Thus, a eutectic may be better defined as a conglomerate of solid solutions. A structural analysis of cocrystals, solid solutions and eutectics has led to an understanding that materials with strong adhesive (hetero) interactions between the unlike components will lead to cocrystals whereas those having stronger cohesive (homo/self) interactions will more often give rise to solid solutions (for similar structures of components) and eutectics (for different structures of components). We demonstrate that the same crystal engineering principles which have been profitably utilized for cocrystal design in the past decade can now be applied to make eutectics as novel composite materials, illustrated by

  1. Stochastic modelling in design of mechanical properties of nanometals

    International Nuclear Information System (INIS)

    Tengen, T.B.; Wejrzanowski, T.; Iwankiewicz, R.; Kurzydlowski, K.J.

    2010-01-01

    Polycrystalline nanometals are being fabricated through different processing routes and conditions. The consequence is that nanometals having the same mean grain size may have different grain size dispersion and, hence, may have different material properties. This has often led to conflicting reports from both theoretical and experimental findings about the evolutions of the mechanical properties of nanomaterials. The present paper employs stochastic model to study the impact of microstructure evolution during grain growth on the mechanical properties of polycrystalline nanometals. The stochastic model for grain growth and the stochastic model for changes in mechanical properties of nanomaterials are proposed. The model for the mechanical properties developed is tested on aluminium samples.Many salient features of the mechanical properties of the aluminium samples are revealed. The results show that the different mechanisms of grain growth impart different nature of response to the material mechanical properties. The conventional, homologous and anomalous temperature dependences of the yield stress have also been revealed to be due to different nature of interactions of the microstructures during evolution.

  2. Hardware-in-the-loop (HIL) nuclear power plant training simulation platform design and validation

    Energy Technology Data Exchange (ETDEWEB)

    Rankin, D.J. [Univ. of Western Ontario, Control and Instrumentation (CIES) Research Group, Dept. of Electrical and Computer Engineering, London, Ontario (Canada)

    2008-07-01

    The design, development and validation of a hardware-in- the-loop (HIL) simulation platform are presented. An Invensys Triconex Tricon v9 safety PLC is interfaced to a nuclear power plant (NPP) simulation suite, replicating the operation of Darlington NPP. Communication between the simulator and external hardware is supported by a National Instruments (NI) data acquisition system (DAQ) and a customized virtual instrument (VI). Event timings within the control loop are thoroughly investigated and an acceptable method for HIL platform communication is developed. A sample application (primary shutdown system (SDS1)) is implemented and evaluated. SDS1 evaluation is performed with focus on steam generator (SG) level low trip scenarios. For this purpose, a design basis accident (DBA) associated with SDS1 regulatory standards is applied to the HIL simulation environment and compared with simulated expected plant operation. Further, the role of the Tricon v9 system within the HIL loop is investigated to establish a basis for the future integration of the entire SDS1 control logic. (author)

  3. A Branch and Bound Approach for Truss Topology Design Problems with Valid Inequalities

    International Nuclear Information System (INIS)

    Cerveira, Adelaide; Agra, Agostinho; Bastos, Fernando; Varum, Humberto

    2010-01-01

    One of the classical problems in the structural optimization field is the Truss Topology Design Problem (TTDP) which deals with the selection of optimal configuration for structural systems for applications in mechanical, civil, aerospace engineering, among others. In this paper we consider a TTDP where the goal is to find the stiffest truss, under a given load and with a bound on the total volume. The design variables are the cross-section areas of the truss bars that must be chosen from a given finite set. This results in a large-scale non-convex problem with discrete variables. This problem can be formulated as a Semidefinite Programming Problem (SDP problem) with binary variables. We propose a branch and bound algorithm to solve this problem. In this paper it is considered a binary formulation of the problem, to take advantage of its structure, which admits a Knapsack problem as subproblem. Thus, trying to improve the performance of the Branch and Bound, at each step, some valid inequalities for the Knapsack problem are included.

  4. Experimental design technique applied to the validation of an instrumental Neutron Activation Analysis procedure

    International Nuclear Information System (INIS)

    Santos, Uanda Paula de M. dos; Moreira, Edson Gonçalves

    2017-01-01

    In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2 k experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 2 3 and the 2 4 , depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN /CNEN-SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions. (author)

  5. Non-clinical models: validation, study design and statistical consideration in safety pharmacology.

    Science.gov (United States)

    Pugsley, M K; Towart, R; Authier, S; Gallacher, D J; Curtis, M J

    2010-01-01

    The current issue of the Journal of Pharmacological and Toxicological Methods (JPTM) focuses exclusively on safety pharmacology methods. This is the 7th year the Journal has published on this topic. Methods and models that specifically relate to methods relating to the assessment of the safety profile of a new chemical entity (NCE) prior to first in human (FIH) studies are described. Since the Journal started publishing on this topic there has been a major effort by safety pharmacologists, toxicologists and regulatory scientists within Industry (both large and small Pharma as well as Biotechnology companies) and also from Contract Research Organizations (CRO) to publish the surgical details of the non-clinical methods utilized but also provide important details related to standard and non-standard (or integrated) study models and designs. These details from core battery and secondary (or ancillary) drug safety assessment methods used in drug development programs have been the focus of these special issues and have been an attempt to provide validation of methods. Similarly, the safety pharmacology issues of the Journal provide the most relevant forum for scientists to present novel and modified methods with direct applicability to determination of drug safety-directly to the safety pharmacology scientific community. The content of the manuscripts in this issue includes the introduction of additional important surgical methods, novel data capture and data analysis methods, improved study design and effects of positive control compounds with known activity in the model. Copyright 2010 Elsevier Inc. All rights reserved.

  6. Bilateral, Misalignment-Compensating, Full-DOF Hip Exoskeleton: Design and Kinematic Validation

    Directory of Open Access Journals (Sweden)

    Karen Junius

    2017-01-01

    Full Text Available A shared design goal for most robotic lower limb exoskeletons is to reduce the metabolic cost of locomotion for the user. Despite this, only a limited amount of devices was able to actually reduce user metabolic consumption. Preservation of the natural motion kinematics was defined as an important requirement for a device to be metabolically beneficial. This requires the inclusion of all human degrees of freedom (DOF in a design, as well as perfect alignment of the rotation axes. As perfect alignment is impossible, compensation for misalignment effects should be provided. A misalignment compensation mechanism for a 3-DOF system is presented in this paper. It is validated by the implementation in a bilateral hip exoskeleton, resulting in a compact and lightweight device that can be donned fast and autonomously, with a minimum of required adaptations. Extensive testing of the prototype has shown that hip range of motion of the user is maintained while wearing the device and this for all three hip DOFs. This allowed the users to maintain their natural motion patterns when they are walking with the novel hip exoskeleton.

  7. Bilateral, Misalignment-Compensating, Full-DOF Hip Exoskeleton: Design and Kinematic Validation

    Science.gov (United States)

    Degelaen, Marc; Lefeber, Nina; Swinnen, Eva; Vanderborght, Bram; Lefeber, Dirk

    2017-01-01

    A shared design goal for most robotic lower limb exoskeletons is to reduce the metabolic cost of locomotion for the user. Despite this, only a limited amount of devices was able to actually reduce user metabolic consumption. Preservation of the natural motion kinematics was defined as an important requirement for a device to be metabolically beneficial. This requires the inclusion of all human degrees of freedom (DOF) in a design, as well as perfect alignment of the rotation axes. As perfect alignment is impossible, compensation for misalignment effects should be provided. A misalignment compensation mechanism for a 3-DOF system is presented in this paper. It is validated by the implementation in a bilateral hip exoskeleton, resulting in a compact and lightweight device that can be donned fast and autonomously, with a minimum of required adaptations. Extensive testing of the prototype has shown that hip range of motion of the user is maintained while wearing the device and this for all three hip DOFs. This allowed the users to maintain their natural motion patterns when they are walking with the novel hip exoskeleton. PMID:28790799

  8. Design and development of driving simulator scenarios for road validation studies

    Energy Technology Data Exchange (ETDEWEB)

    Dols Ruiz, J.F.

    2016-07-01

    In recent years, the number of road-based studies using driving simulators is growing significantly. This allows evaluating controlled situations that otherwise would require disproportionate observations in time and/or cost. The Institute of Design and Manufacturing (IDF) of the Polytechnic University of Valencia (UPV) has developed, in collaboration with the Engineering Research Group Highway (GIIC) of the UPV, a low cost simulator that allows rapid implementation and effectively a new methodology for validation studies of different roads through the implementation in the simulator scenarios of existing roads. This methodology allows the development of new scenarios based on the analysis of a layers-file system. Each layer includes different information from the road, such as mapping, geometry, signaling, aerial photos, etc. The creation of the simulated scenario is very fast based on the geometric design software, making it easier to consulting firms using the system that can evaluate and audit a particular route, obtaining reliable conclusions at minimal cost, even if the road is not actually built. This paper describes the basic structure of the layers generated for developing scenarios and guidelines for the implementation thereof. Finally the application of this methodology to a case of success will be described. (Author)

  9. Experimental design technique applied to the validation of an instrumental Neutron Activation Analysis procedure

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Uanda Paula de M. dos; Moreira, Edson Gonçalves, E-mail: uandapaula@gmail.com, E-mail: emoreira@ipen.br [Instituto de Pesquisas Energéticas e Nucleares (IPEN/CNEN-SP), São Paulo, SP (Brazil)

    2017-07-01

    In this study optimization of procedures and standardization of Instrumental Neutron Activation Analysis (INAA) method were carried out for the determination of the elements bromine, chlorine, magnesium, manganese, potassium, sodium and vanadium in biological matrix materials using short irradiations at a pneumatic system. 2{sup k} experimental designs were applied for evaluation of the individual contribution of selected variables of the analytical procedure in the final mass fraction result. The chosen experimental designs were the 2{sup 3} and the 2{sup 4}, depending on the radionuclide half life. Different certified reference materials and multi-element comparators were analyzed considering the following variables: sample decay time, irradiation time, counting time and sample distance to detector. Comparator concentration, sample mass and irradiation time were maintained constant in this procedure. By means of the statistical analysis and theoretical and experimental considerations, it was determined the optimized experimental conditions for the analytical methods that will be adopted for the validation procedure of INAA methods in the Neutron Activation Analysis Laboratory (LAN) of the Research Reactor Center (CRPq) at the Nuclear and Energy Research Institute (IPEN /CNEN-SP). Optimized conditions were estimated based on the results of z-score tests, main effect, interaction effects and better irradiation conditions. (author)

  10. A new adaptive videogame for training attention and executive functions: design principles and initial validation

    Science.gov (United States)

    Montani, Veronica; De Filippo De Grazia, Michele; Zorzi, Marco

    2014-01-01

    A growing body of evidence suggests that action videogames could enhance a variety of cognitive skills and more specifically attention skills. The aim of this study was to develop a novel adaptive videogame to support the rehabilitation of the most common consequences of traumatic brain injury (TBI), that is the impairment of attention and executive functions. TBI patients can be affected by psychomotor slowness and by difficulties in dealing with distraction, maintain a cognitive set for a long time, processing different simultaneously presented stimuli, and planning purposeful behavior. Accordingly, we designed a videogame that was specifically conceived to activate those functions. Playing involves visuospatial planning and selective attention, active maintenance of the cognitive set representing the goal, and error monitoring. Moreover, different game trials require to alternate between two tasks (i.e., task switching) or to perform the two tasks simultaneously (i.e., divided attention/dual-tasking). The videogame is controlled by a multidimensional adaptive algorithm that calibrates task difficulty on-line based on a model of user performance that is updated on a trial-by-trial basis. We report simulations of user performance designed to test the adaptive game as well as a validation study with healthy participants engaged in a training protocol. The results confirmed the involvement of the cognitive abilities that the game is supposed to enhance and suggested that training improved attentional control during play. PMID:24860529

  11. A new adaptive videogame for training attention and executive functions: Design principles and initial validation

    Directory of Open Access Journals (Sweden)

    Veronica eMontani

    2014-05-01

    Full Text Available A growing body of evidence suggests that action videogames could enhance a variety of cognitive skills and more specifically attention skills. The aim of this study was to develop a novel adaptive videogame to support the rehabilitation of the most common consequences of traumatic brain injury (TBI, that is the impairment of attention and executive functions. TBI patients can be affected by psychomotor slowness and by difficulties in dealing with distraction, maintain a cognitive set for a long time, processing different simultaneously presented stimuli, and planning purposeful behaviour. Accordingly, we designed a videogame that was specifically conceived to activate those functions. Playing involves visuospatial planning and selective attention, active maintenance of the cognitive set representing the goal, and error monitoring. Moreover, different game trials require to alternate between two tasks (i.e., task switching or to perform the two tasks simultaneously (i.e., divided attention / dual-tasking. The videogame is controlled by a multidimensional adaptive algorithm that calibrates task difficulty on-line based on a model of user performance that is updated on a trial-by-trial basis. We report simulations of user performance designed to test the adaptive game as well as a validation study with healthy participants engaged in a training protocol. The results confirmed the involvement of the cognitive abilities that the game is supposed to enhance and suggested that training improved attentional control during play.

  12. A new adaptive videogame for training attention and executive functions: design principles and initial validation.

    Science.gov (United States)

    Montani, Veronica; De Filippo De Grazia, Michele; Zorzi, Marco

    2014-01-01

    A growing body of evidence suggests that action videogames could enhance a variety of cognitive skills and more specifically attention skills. The aim of this study was to develop a novel adaptive videogame to support the rehabilitation of the most common consequences of traumatic brain injury (TBI), that is the impairment of attention and executive functions. TBI patients can be affected by psychomotor slowness and by difficulties in dealing with distraction, maintain a cognitive set for a long time, processing different simultaneously presented stimuli, and planning purposeful behavior. Accordingly, we designed a videogame that was specifically conceived to activate those functions. Playing involves visuospatial planning and selective attention, active maintenance of the cognitive set representing the goal, and error monitoring. Moreover, different game trials require to alternate between two tasks (i.e., task switching) or to perform the two tasks simultaneously (i.e., divided attention/dual-tasking). The videogame is controlled by a multidimensional adaptive algorithm that calibrates task difficulty on-line based on a model of user performance that is updated on a trial-by-trial basis. We report simulations of user performance designed to test the adaptive game as well as a validation study with healthy participants engaged in a training protocol. The results confirmed the involvement of the cognitive abilities that the game is supposed to enhance and suggested that training improved attentional control during play.

  13. Spatiotemporally Representative and Cost-Efficient Sampling Design for Validation Activities in Wanglang Experimental Site

    Directory of Open Access Journals (Sweden)

    Gaofei Yin

    2017-11-01

    Full Text Available Spatiotemporally representative Elementary Sampling Units (ESUs are required for capturing the temporal variations in surface spatial heterogeneity through field measurements. Since inaccessibility often coexists with heterogeneity, a cost-efficient sampling design is mandatory. We proposed a sampling strategy to generate spatiotemporally representative and cost-efficient ESUs based on the conditioned Latin hypercube sampling scheme. The proposed strategy was constrained by multi-temporal Normalized Difference Vegetation Index (NDVI imagery, and the ESUs were limited within a sampling feasible region established based on accessibility criteria. A novel criterion based on the Overlapping Area (OA between the NDVI frequency distribution histogram from the sampled ESUs and that from the entire study area was used to assess the sampling efficiency. A case study in Wanglang National Nature Reserve in China showed that the proposed strategy improves the spatiotemporally representativeness of sampling (mean annual OA = 74.7% compared to the single-temporally constrained (OA = 68.7% and the random sampling (OA = 63.1% strategies. The introduction of the feasible region constraint significantly reduces in-situ labour-intensive characterization necessities at expenses of about 9% loss in the spatiotemporal representativeness of the sampling. Our study will support the validation activities in Wanglang experimental site providing a benchmark for locating the nodes of automatic observation systems (e.g., LAINet which need a spatially distributed and temporally fixed sampling design.

  14. A Validation of Object-Oriented Design Metrics as Quality Indicators

    Science.gov (United States)

    Basili, Victor R.; Briand, Lionel C.; Melo, Walcelio

    1997-01-01

    This paper presents the results of a study in which we empirically investigated the suits of object-oriented (00) design metrics introduced in another work. More specifically, our goal is to assess these metrics as predictors of fault-prone classes and, therefore, determine whether they can be used as early quality indicators. This study is complementary to the work described where the same suite of metrics had been used to assess frequencies of maintenance changes to classes. To perform our validation accurately, we collected data on the development of eight medium-sized information management systems based on identical requirements. All eight projects were developed using a sequential life cycle model, a well-known 00 analysis/design method and the C++ programming language. Based on empirical and quantitative analysis, the advantages and drawbacks of these 00 metrics are discussed. Several of Chidamber and Kamerer's 00 metrics appear to be useful to predict class fault-proneness during the early phases of the life-cycle. Also, on our data set, they are better predictors than 'traditional' code metrics, which can only be collected at a later phase of the software development processes.

  15. Mechanical and physical properties of 2 1/4 Cr--1 Mo steel in support of CRBRP steam generator design

    International Nuclear Information System (INIS)

    Brinkman, C.R.; Williams, R.K.; Klueh, R.L.; Hebble, T.L.

    1975-01-01

    Mechanical and physical property tests on annealed 2 1 / 4 Cr-1 Mo steel were conducted in an effort to define behavior in support of the design of the Clinch River Breeder Reactor Plant (CRBRP) steam generator design. Interim empirical expressions and/or data are reported from the results of tensile, creep, fatigue, creep-fatigue, subcritical crack growth, thermal conductivity, thermal diffusivity, and thermal expansion tests and analysis. These expressions cover behavior, where appropriate, over a range of temperatures from 25 to as high as 700 0 C. Comparisons between thermal conductivity and diffusivity values and those found in the American Society of Mechanical Engineers (ASME) Code indicated that the new values were significantly higher than those found presently in the Code. The importance and complexity of obtaining valid mechanical and physical properties for the Clinch River Breeder Reactor Plant (CRBRP) steam generator are discussed. (U.S.)

  16. Validation of a new design of tellurium dioide-irradiated target

    Energy Technology Data Exchange (ETDEWEB)

    Fllaoui, Aziz; Ghamad, Younes; Zoubir, Brahim; Ayaz, Zinel Abidine; El Morabiti, Aissam; Amayoud, Hafid [Centre National de l' Energie des Sciences et des Techniques Nucleaires, Rabat (Morocco); Chakir, El Mahjoub [Nuclear Physics Department, University Ibn Toufail, Kenitra (Morocco)

    2016-10-15

    Production of iodine-131 by neutron activation of tellurium in tellurium dioxide (TeO{sub 2}) material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gas welding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ≤ 10 - 4 mbr.L/s, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics). To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to 600 .deg. C with the appearance of deformations on lids beyond 450 .deg. C. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes-convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from 4 hours of irradiation at a power level of 0.5 MW up to 35 hours (7 h/d for 5 days a week) at 1.5 MW. The results show that the irradiated targets are

  17. Validation of a New Design of Tellurium Dioxide-Irradiated Target

    Directory of Open Access Journals (Sweden)

    Aziz Fllaoui

    2016-10-01

    Full Text Available Production of iodine-131 by neutron activation of tellurium in tellurium dioxide (TeO2 material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gas welding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ≤ 10−4 mbr.L/s, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics. To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to 600°C with the appearance of deformations on lids beyond 450°C. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes—convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from 4 hours of irradiation at a power level of 0.5 MW up to 35 hours (7 h/d for 5 days a week at 1.5 MW. The results show that the irradiated targets are

  18. Design and validation of a questionnaire to measure the attitudes of hospital staff concerning pandemic influenza.

    Science.gov (United States)

    Naghavi, Seyed Hamid Reza; Shabestari, Omid; Roudsari, Abdul V; Harrison, John

    2012-03-01

    When pandemics lead to a higher workload in the healthcare sector, the attitude of healthcare staff and, more importantly, the ability to predict the rate of absence due to sickness are crucial factors in emergency preparedness and resource allocation. The aim of this study was to design and validate a questionnaire to measure the attitude of hospital staff toward work attendance during an influenza pandemic. An online questionnaire was designed and electronically distributed to the staff of a teaching medical institution in the United Kingdom. The questionnaire was designed de novo following discussions with colleagues at Imperial College and with reference to the literature on the severe acute respiratory syndrome (SARS) epidemic. The questionnaire included 15 independent fact variables and 33 dependent measure variables. A total of 367 responses were received in this survey. The data from the measurement variables were not normally distributed. Three different methods (standardized residuals, Mahalanobis distance and Cook's distance) were used to identify the outliers. In all, 19 respondents (5.17%) were identified as outliers and were excluded. The responses to this questionnaire had a wide range of missing data, from 1 to 74 cases in the measured variables. To improve the quality of the data, missing value analysis, using Expectation Maximization Algorithm (EMA) with a non-normal distribution model, was applied to the responses. The collected data were checked for homoscedasticity and multicollinearity of the variables. These tests suggested that some of the questions should be merged. In the last step, the reliability of the questionnaire was evaluated. This process showed that three questions reduced the reliability of the questionnaire. Removing those questions helped to achieve the desired level of reliability. With the changes proposed in this article, the questionnaire for measuring staff attitudes concerning pandemic influenza can be converted to a

  19. Development and validation of Dutch version of Lasater Clinical Judgment Rubric in hospital practice: An instrument design study.

    Science.gov (United States)

    Vreugdenhil, Jettie; Spek, Bea

    2018-03-01

    Clinical reasoning in patient care is a skill that cannot be observed directly. So far, no reliable, valid instrument exists for the assessment of nursing students' clinical reasoning skills in hospital practice. Lasater's clinical judgment rubric (LCJR), based on Tanner's model "Thinking like a nurse" has been tested, mainly in academic simulation settings. The aim is to develop a Dutch version of the LCJR (D-LCJR) and to test its psychometric properties when used in a hospital traineeship context. A mixed-model approach was used to develop and to validate the instrument. Ten dedicated educational units in a university hospital. A well-mixed group of 52 nursing students, nurse coaches and nurse educators. A Delphi panel developed the D-LCJR. Students' clinical reasoning skills were assessed "live" by nurse coaches, nurse educators and students who rated themselves. The psychometric properties tested during the assessment process are reliability, reproducibility, content validity and construct validity by testing two hypothesis: 1) a positive correlation between assessed and self-reported sum scores (convergent validity) and 2) a linear relation between experience and sum score (clinical validity). The obtained D-LCJR was found to be internally consistent, Cronbach's alpha 0.93. The rubric is also reproducible with intraclass correlations between 0.69 and 0.78. Experts judged it to be content valid. The two hypothesis were both tested significant, supporting evidence for construct validity. The translated and modified LCJR, is a promising tool for the evaluation of nursing students' development in clinical reasoning in hospital traineeships, by students, nurse coaches and nurse educators. More evidence on construct validity is necessary, in particular for students at the end of their hospital traineeship. Based on our research, the D-LCJR applied in hospital traineeships is a usable and reliable tool. Copyright © 2017 Elsevier Ltd. All rights reserved.

  20. Designing of Bulk Nano-Structures with Enhanced Thermoelectric Properties

    National Research Council Canada - National Science Library

    Kanatzidis, Mercouri; Hogan, Timothy; Murray, Chris

    2007-01-01

    .... K2Bi8Se13 is a member of this series and was found to be a promising thermoelectric. The charge transport properties were studied under pressure, where a significant increase in the power factor was observed...

  1. Designing of Bulk Nano-Structures With Enhanced Thermoelectric Properties

    National Research Council Canada - National Science Library

    Kanatzidis, Mercouri G

    2007-01-01

    .... K2Bi8Se13 is a member of this series and was found to be a promising thermoelectric. The charge transport properties were studied under pressure, where a significant increase in the power factor was observed...

  2. Retrieval and Validation of aerosol optical properties from AHI measurements: impact of surface reflectance assumption

    Science.gov (United States)

    Lim, H.; Choi, M.; Kim, J.; Go, S.; Chan, P.; Kasai, Y.

    2017-12-01

    This study attempts to retrieve the aerosol optical properties (AOPs) based on the spectral matching method, with using three visible and one near infrared channels (470, 510, 640, 860nm). This method requires the preparation of look-up table (LUT) approach based on the radiative transfer modeling. Cloud detection is one of the most important processes for guaranteed quality of AOPs. Since the AHI has several infrared channels, which are very advantageous for cloud detection, clouds can be removed by using brightness temperature difference (BTD) and spatial variability test. The Yonsei Aerosol Retrieval (YAER) algorithm is basically utilized on a dark surface, therefore a bright surface (e.g., desert, snow) should be removed first. Then we consider the characteristics of the reflectance of land and ocean surface using three visible channels. The known surface reflectivity problem in high latitude area can be solved in this algorithm by selecting appropriate channels through improving tests. On the other hand, we retrieved the AOPs by obtaining the visible surface reflectance using NIR to normalized difference vegetation index short wave infrared (NDVIswir) relationship. ESR tends to underestimate urban and cropland area, we improved the visible surface reflectance considering urban effect. In this version, ocean surface reflectance is using the new cox and munk method which considers ocean bidirectional reflectance distribution function (BRDF). Input of this method has wind speed, chlorophyll, salinity and so on. Based on validation results with the sun-photometer measurement in AErosol Robotic NETwork (AERONET), we confirm that the quality of Aerosol Optical Depth (AOD) from the YAER algorithm is comparable to the product from the Japan Aerospace Exploration Agency (JAXA) retrieval algorithm. Our future update includes a consideration of improvement land surface reflectance by hybrid approach, and non-spherical aerosols. This will improve the quality of YAER

  3. Experimental validation of 3D printed material behaviors and their influence on the structural topology design

    Science.gov (United States)

    Yang, Kai Ke; Zhu, Ji Hong; Wang, Chuang; Jia, Dong Sheng; Song, Long Long; Zhang, Wei Hong

    2018-05-01

    The purpose of this paper is to investigate the structures achieved by topology optimization and their fabrications by 3D printing considering the particular features of material microstructures and macro mechanical performances. Combining Digital Image Correlation and Optical Microscope, this paper experimentally explored the anisotropies of stiffness and strength existing in the 3D printed polymer material using Stereolithography (SLA) and titanium material using Selective Laser Melting (SLM). The standard specimens and typical structures obtained by topology optimization were fabricated along different building directions. On the one hand, the experimental results of these SLA produced structures showed stable properties and obviously anisotropic rules in stiffness, ultimate strengths and places of fractures. Further structural designs were performed using topology optimization when the particular mechanical behaviors of SLA printed materials were considered, which resulted in better structural performances compared to the optimized designs using `ideal' isotropic material model. On the other hand, this paper tested the mechanical behaviors of SLM printed multiscale lattice structures which were fabricated using the same metal powder and the same machine. The structural stiffness values are generally similar while the strength behaviors show a difference, which are mainly due to the irregular surface quality of the tiny structural branches of the lattice. The above evidences clearly show that the consideration of the particular behaviors of 3D printed materials is therefore indispensable for structural design and optimization in order to improve the structural performance and strengthen their practical significance.

  4. Experimental validation of 3D printed material behaviors and their influence on the structural topology design

    Science.gov (United States)

    Yang, Kai Ke; Zhu, Ji Hong; Wang, Chuang; Jia, Dong Sheng; Song, Long Long; Zhang, Wei Hong

    2018-02-01

    The purpose of this paper is to investigate the structures achieved by topology optimization and their fabrications by 3D printing considering the particular features of material microstructures and macro mechanical performances. Combining Digital Image Correlation and Optical Microscope, this paper experimentally explored the anisotropies of stiffness and strength existing in the 3D printed polymer material using Stereolithography (SLA) and titanium material using Selective Laser Melting (SLM). The standard specimens and typical structures obtained by topology optimization were fabricated along different building directions. On the one hand, the experimental results of these SLA produced structures showed stable properties and obviously anisotropic rules in stiffness, ultimate strengths and places of fractures. Further structural designs were performed using topology optimization when the particular mechanical behaviors of SLA printed materials were considered, which resulted in better structural performances compared to the optimized designs using `ideal' isotropic material model. On the other hand, this paper tested the mechanical behaviors of SLM printed multiscale lattice structures which were fabricated using the same metal powder and the same machine. The structural stiffness values are generally similar while the strength behaviors show a difference, which are mainly due to the irregular surface quality of the tiny structural branches of the lattice. The above evidences clearly show that the consideration of the particular behaviors of 3D printed materials is therefore indispensable for structural design and optimization in order to improve the structural performance and strengthen their practical significance.

  5. Validation of Printed Circuit Heat Exchanger Design Code KAIST{sub H}XD

    Energy Technology Data Exchange (ETDEWEB)

    Baik, Seungjoon; Kim, Seong Gu; Lee, Jekyoung; Lee, Jeong Ik [KAIST, Daejeon (Korea, Republic of)

    2015-05-15

    Supercritical carbon dioxide (S-CO{sub 2}) Brayton cycle has been suggested for the SFR due to the relatively mild sodium-CO{sub 2} interaction. The S-CO{sub 2} power conversion cycle can achieve not only high safety but also high efficiency with SFR core thermal condition. However, due to the dramatic property change near the critical point, the inlet pressure and temperature conditions of compressor can have significant effect on the overall cycle efficiency. To maintain the inlet condition of compressor, a sensitive precooler control system is required for stable operation. Therefore understanding the precooler performance is essential for the S-CO{sub 2} power conversion system. According to experimental result, designed PCHE showed high effectiveness in various operating regions. Comparing the experimental and the design data, heat transfer performance estimation showed less than 6% error. On the other hand, the pressure drop estimation showed large gap. The water side pressure drop showed 50-70% under estimation. Because the form losses were not included in the design code, water side pressure drop estimation result seems reliable. However, the CO{sub 2} side showed more than 70% over estimation in the pressure drop from the code. The authors suspect that the differences may have occurred by the channel corner shape. The real channel has round corners and smooth edge, but the correlation is based on the sharp edged zig-zag channel. Further studies are required to understand and interpret the results correctly in the future.

  6. A pilot validation of a modified Illness Perceptions Questionnaire designed to predict response to cognitive therapy for psychosis.

    Science.gov (United States)

    Marcus, Elena; Garety, Philippa; Weinman, John; Emsley, Richard; Dunn, Graham; Bebbington, Paul; Freeman, Daniel; Kuipers, Elizabeth; Fowler, David; Hardy, Amy; Waller, Helen; Jolley, Suzanne

    2014-12-01

    Clinical responsiveness to cognitive behavioural therapy for psychosis (CBTp) varies. Recent research has demonstrated that illness perceptions predict active engagement in therapy, and, thereby, better outcomes. In this study, we aimed to investigate the psychometric properties of a modification of the Illness Perceptions Questionnaire (M-IPQ) designed to predict response following CBTp. Fifty-six participants with persistent, distressing delusions completed the M-IPQ; forty before a brief CBT intervention targeting persecutory ideation and sixteen before and after a control condition. Additional predictors of outcome (delusional conviction, symptom severity and belief inflexibility) were assessed at baseline. Outcomes were assessed at baseline and at follow-up four to eight weeks later. The M-IPQ comprised two factors measuring problem duration and therapy-specific perceptions of Cure/Control. Associated subscales, formed by summing the relevant items for each factor, were reliable in their structure. The Cure/Control subscale was also reliable over time; showed convergent validity with other predictors of outcome; predicted therapy outcomes; and differentially predicted treatment effects. We measured outcome without an associated measure of engagement, in a small sample. Findings are consistent with hypothesis and existing research, but require replication in a larger, purposively recruited sample. The Cure/Control subscale of the M-IPQ shows promise as a predictor of response to therapy. Specifically targeting these illness perceptions in the early stages of cognitive behavioural therapy may improve engagement and, consequently, outcomes. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  7. In silico design of PHA synthase and its validation by PHAs producing bacterial isolates

    Directory of Open Access Journals (Sweden)

    Susrita Sahoo

    2017-10-01

    Full Text Available Biopolymers are important alternatives to the petroleum-based plastics due to environment friendly manufacturing processes, biodegradability and biocompatibility. Therefore use of novel biopolymers such as polylactide, polysaccharides, aliphatic polyesters and polyhydroxyalkonoates (PHAs is of interest. PHAs are biodegradable polyesters of hydroxyalkanoates (HA produced from renewable resources by using microorganisms as intracellular carbon and energy storage compounds.  Even though PHAs are promising candidate for biodegradable polymers, however, the production cost limits their application on an industrial scale. Therefore an attempt was made to model different PHAs synthases which are the key enzyme in the biosynthesis of Polyhydroxyalkanoates as the structural information of this enzyme is in dark veil.Then molecular docking  of class I  PHA  Synthase from Ralstonia Eutrophia was done to study the PHA synthase activity. As there are lots of strain which needs to explore for the production of PHA. This investigation leads to find out the most industrial applicable microbes. Few bacterial isolates from soil sample were screened for production of PHA followed by the validation of the enzymatic activity and its product characterization to understand its structural properties.

  8. Experimental and numerical validation of a two-region-designed pebble bed reactor with dynamic core

    International Nuclear Information System (INIS)

    Jiang, S.Y.; Yang, X.T.; Tang, Z.W.; Wang, W.J.; Tu, J.Y.; Liu, Z.Y.; Li, J.

    2012-01-01

    Highlights: ► The experimental installation has been built to investigate the pebble flow. ► The feasibility of two-region pebble bed reactor has been verified. ► The pebble flow is more uniform in a taller vessel than that in a lower vessel. ► Larger base cone angle will decrease the scale of the stagnant zone. - Abstract: The pebble flow is the principal issue for the design of the pebble bed reactor. In order to verify the feasibility of a two-region-designed pebble bed reactor, the experimental installation with a taller vessel has been built, which is proportional to the real pebble bed reactor. With the aid of the experimental installation, the stable establishment and maintenance of the two-region arrangement has been verified, at the same time, the applicability of the DEM program has been also validated. Research results show: (1) The pebble's bouncing on the free surface is an important factor for the mixing of the different colored pebbles. (2) Through the guide plates installed in the top of the pebble packing, the size of the mixing zone can be reduced from 6–7 times to 3–4 times the pebble diameter. (3) The relationship between the width of the central region and the ratio of loading pebbles is approximately linear in the taller vessel. (4) The heighten part of the pebble packing can improve the uniformity of the flowing in the lower. (5) To increase the base cone angle can decrease the scale of the stagnant zone. All of these conclusions are meaningful to the design of the real pebble reactor.

  9. A generic approach for the design of whole-genome oligoarrays, validated for genomotyping, deletion mapping and gene expression analysis on Staphylococcus aureus

    Directory of Open Access Journals (Sweden)

    Renzoni Adriana

    2005-06-01

    Full Text Available Abstract Background DNA microarray technology is widely used to determine the expression levels of thousands of genes in a single experiment, for a broad range of organisms. Optimal design of immobilized nucleic acids has a direct impact on the reliability of microarray results. However, despite small genome size and complexity, prokaryotic organisms are not frequently studied to validate selected bioinformatics approaches. Relying on parameters shown to affect the hybridization of nucleic acids, we designed freely available software and validated experimentally its performance on the bacterial pathogen Staphylococcus aureus. Results We describe an efficient procedure for selecting 40–60 mer oligonucleotide probes combining optimal thermodynamic properties with high target specificity, suitable for genomic studies of microbial species. The algorithm for filtering probes from extensive oligonucleotides libraries fitting standard thermodynamic criteria includes positional information of predicted target-probe binding regions. This algorithm efficiently selected probes recognizing homologous gene targets across three different sequenced genomes of Staphylococcus aureus. BLAST analysis of the final selection of 5,427 probes yielded >97%, 93%, and 81% of Staphylococcus aureus genome coverage in strains N315, Mu50, and COL, respectively. A manufactured oligoarray including a subset of control Escherichia coli probes was validated for applications in the fields of comparative genomics and molecular epidemiology, mapping of deletion mutations and transcription profiling. Conclusion This generic chip-design process merging sequence information from several related genomes improves genome coverage even in conserved regions.

  10. [Design and validation of a questionnaire to assess the level of general knowledge on eating disorders in students of Health Sciences].

    Science.gov (United States)

    Sánchez Socarrás, Violeida; Aguilar Martínez, Alicia; Vaqué Crusellas, Cristina; Milá Villarroel, Raimon; González Rivas, Fabián

    2016-01-01

    To design and validate a questionnaire to assess the level of knowledge regarding eating disorders in college students. Observational, prospective, and longitudinal study, with the design of the questionnaire based on a conceptual review and validation by a cognitive pre-test and pilot test-retest, with analysis of the psychometric properties in each application. University Foundation of Bages, Barcelona. Marco community care. A total of 140 students from Health Sciences; 53 women and 87 men with a mean age of 21.87 years; 28 participated in the pre-test and 112 in the test-retests, 110 students completed the study. Validity and stability study using Cronbach α and Pearson product-moment correlation coefficient statistics; relationship skills with sex and type of study, non-parametric statistical Mann-Whitney and Kruskal-Wallis tests; for demographic variables, absolute or percentage frequencies, as well as mean, central tendency and standard deviation as measures of dispersion were calculated. The statistical significance level was 95% confidence. The questionnaire was obtained that had 10 questions divided into four dimensions (classification, demographics characteristics of patients, risk factors and clinical manifestations of eating disorders). The scale showed good internal consistency in its final version (Cronbach α=0.724) and adequate stability (Pearson correlation 0.749). The designed tool can be accurately used to assess Health Sciences students' knowledge of eating disorders. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  11. Design and validation of standardized clinical and functional remission criteria in schizophrenia

    Science.gov (United States)

    Mosolov, Sergey N; Potapov, Andrey V; Ushakov, Uriy V; Shafarenko, Aleksey A; Kostyukova, Anastasiya B

    2014-01-01

    Background International Remission Criteria (IRC) for schizophrenia were developed recently by a group of internationally known experts. The IRC detect only 10%–30% of cases and do not cover the diversity of forms and social functioning. Our aim was to design a more applicable tool and validate its use – the Standardized Clinical and Functional Remission Criteria (SCFRC). Methods We used a 6-month follow-up study of 203 outpatients from two Moscow centers and another further sample of stable patients from a 1-year controlled trial of atypical versus typical medication. Diagnosis was confirmed by International Classification of Diseases Version 10 (ICD10) criteria and the Mini-International Neuropsychiatric Interview (MINI). Patients were assessed by the Positive and Negative Syndrome Scale, including intensity threshold, and further classified using the Russian domestic remission criteria and the level of social and personal functioning, according to the Personal and Social Performance Scale (PSP). The SCFRC were formulated and were validated by a data reanalysis on the first population sample and on a second independent sample (104 patients) and in an open-label prospective randomized 12-month comparative study of risperidone long-acting injectable (RLAI) versus olanzapine. Results Only 64 of the 203 outpatients (31.5%) initially met the IRC, and 53 patients (26.1%) met the IRC after 6 months, without a change in treatment. Patients who were in remission had episodic and progressive deficit (39.6%), or remittent (15%) paranoid schizophrenia, or schizoaffective disorder (17%). In addition, 105 patients of 139 (51.7%), who did not meet symptomatic IRC, remained stable within the period. Reanalysis of data revealed that 65.5% of the patients met the SCFRC. In the controlled trial, 70% of patients in the RLAI group met the SCFRC and only 19% the IRC. In the routine treatment group, 55.9% met the SCFRC and only 5.7% the IRC. Results of the further independent

  12. Construction and properties of Box-Behnken designs

    OpenAIRE

    Jo, Jinnam

    1992-01-01

    Box-Behnken designs are used to estimate parameters in a second-order response surface model (Box and Behnken, 1960). These designs are formed by combining ideas from incomplete block designs (BIBD or PBIBD) and factorial experiments, specifically 2k full or 2k-1 fractional factorials. In this dissertation, a more general mathematical formulation of the Box-Behnken method is provided, a general expression for the coefficient matrix in the least squares analysis for estimatin...

  13. Design and Validation of a Breathing Detection System for Scuba Divers

    Directory of Open Access Journals (Sweden)

    Corentin Altepe

    2017-06-01

    Full Text Available Drowning is the major cause of death in self-contained underwater breathing apparatus (SCUBA diving. This study proposes an embedded system with a live and light-weight algorithm which detects the breathing of divers through the analysis of the intermediate pressure (IP signal of the SCUBA regulator. A system composed mainly of two pressure sensors and a low-power microcontroller was designed and programmed to record the pressure sensors signals and provide alarms in absence of breathing. An algorithm was developed to analyze the signals and identify inhalation events of the diver. A waterproof case was built to accommodate the system and was tested up to a depth of 25 m in a pressure chamber. To validate the system in the real environment, a series of dives with two different types of workload requiring different ranges of breathing frequencies were planned. Eight professional SCUBA divers volunteered to dive with the system to collect their IP data in order to participate to validation trials. The subjects underwent two dives, each of 52 min on average and a maximum depth of 7 m. The algorithm was optimized for the collected dataset and proved a sensitivity of inhalation detection of 97.5% and a total number of 275 false positives (FP over a total recording time of 13.9 h. The detection algorithm presents a maximum delay of 5.2 s and requires only 800 bytes of random-access memory (RAM. The results were compared against the analysis of video records of the dives by two blinded observers and proved a sensitivity of 97.6% on the data set. The design includes a buzzer to provide audible alarms to accompanying dive buddies which will be triggered in case of degraded health conditions such as near drowning (absence of breathing, hyperventilation (breathing frequency too high and skip-breathing (breathing frequency too low measured by the improper breathing frequency. The system also measures the IP at rest before the dive and indicates with

  14. Validity of a Newly-Designed Rectilinear Stepping Ergometer Submaximal Exercise Test to Assess Cardiorespiratory Fitness.

    Science.gov (United States)

    Zhang, Rubin; Zhan, Likui; Sun, Shaoming; Peng, Wei; Sun, Yining

    2017-09-01

    The maximum oxygen uptake (V̇O 2 max), determined from graded maximal or submaximal exercise tests, is used to classify the cardiorespiratory fitness level of individuals. The purpose of this study was to examine the validity and reliability of the YMCA submaximal exercise test protocol performed on a newly-designed rectilinear stepping ergometer (RSE) that used up and down reciprocating vertical motion in place of conventional circular motion and giving precise measurement of workload, to determine V̇O 2 max in young healthy male adults. Thirty-two young healthy male adults (32 males; age range: 20-35 years; height: 1.75 ± 0.05 m; weight: 67.5 ± 8.6 kg) firstly participated in a maximal-effort graded exercise test using a cycle ergometer (CE) to directly obtain measured V̇O 2 max. Subjects then completed the progressive multistage test on the RSE beginning at 50W and including additional stages of 70, 90, 110, 130, and 150W, and the RSE YMCA submaximal test consisting of a workload increase every 3 minutes until the termination criterion was reached. A metabolic equation was derived from the RSE multistage exercise test to predict oxygen consumption (V̇O 2 ) from power output (W) during the submaximal exercise test (V̇O 2 (mL·min -1 )=12.4 ×W(watts)+3.5 mL·kg -1 ·min -1 ×M+160mL·min -1 , R 2 = 0.91, standard error of the estimate (SEE) = 134.8mL·min -1 ). A high correlation was observed between the RSE YMCA estimated V̇O 2 max and the CE measured V̇O 2 max (r=0.87). The mean difference between estimated and measured V̇O 2 max was 2.5 mL·kg -1 ·min -1 , with an SEE of 3.55 mL·kg -1 ·min -1 . The data suggest that the RSE YMCA submaximal exercise test is valid for predicting V̇O 2 max in young healthy male adults. The findings show that the rectilinear stepping exercise is an effective submaximal exercise for predicting V̇O 2 max. The newly-designed RSE may be potentially further developed as an alternative ergometer for assessing

  15. Wall Turbulence with Designer Properties: Identification, Characterization and Manipulation of Energy Pathways

    Science.gov (United States)

    2016-02-26

    AFRL-AFOSR-VA-TR-2016-0108 Wall turbulence with designer properties Beverley Mckeon CALIFORNIA INSTITUTE OF TECHNOLOGY Final Report 02/26/2016... Wall turbulence with designer properties: Identification, characterization & manipulation of energy pathways 5a. CONTRACT NUMBER 5b. GRANT NUMBER...identification, characterization and manipulation of energy pathways in wall turbulence . The objectives were pursued separately and collaboratively by the

  16. Property Integration: Componentless Design Techniques and Visualization Tools

    DEFF Research Database (Denmark)

    El-Halwagi, Mahmoud M; Glasgow, I.M.; Eden, Mario Richard

    2004-01-01

    integration is defined as a functionality-based, holistic approach to the allocation and manipulation of streams and processing units, which is based on tracking, adjusting, assigning, and matching functionalities throughout the process. Revised lever arm rules are devised to allow optimal allocation while...... maintaining intra- and interstream conservation of the property-based clusters. The property integration problem is mapped into the cluster domain. This dual problem is solved in terms of clusters and then mapped to the primal problem in the property domain. Several new rules are derived for graphical...... techniques. Particularly, systematic rules and visualization techniques for the identification of optimal mixing of streams and their allocation to units. Furthermore, a derivation of the correspondence between clustering arms and fractional contribution of streams is presented. This correspondence...

  17. A formal design verification and validation on the human factors of a computerized information system in nuclear power plants

    International Nuclear Information System (INIS)

    Lee, Yong Hee; Park, Jae Chang; Cheon, Se Woo; Jung, Kwang Tae; Baek, Seung Min; Han, Seung; Park, Hee Suk; Son, Ki Chang; Kim, Jung Man; Jung Yung Woo

    1999-11-01

    This report describe a technical transfer under the title of ''A formal design verification and validation on the human factors of a computerized information system in nuclear power plants''. Human factors requirements for the information system designs are extracted from various regulatory and industrial standards and guidelines, and interpreted into a more specific procedures and checklists for verifying the satisfaction of those requirements. A formalized implementation plan is established for human factors verification and validation of a computerized information system in nuclear power plants. Additionally, a Computer support system, named as DIMS-web (design Issue Management System), is developed based upon web internet environment so as to enhance the implementation of the human factors activities. DIMS-Web has three maine functions: supporting requirements review, tracking design issues, and management if issues screening evaluation. DIMS-Web shows its benefits in practice through a trial application to the design review of CFMS for YGN nuclear unit 5 and 6. (author)

  18. Development and Validation of Marker-Aided Selection Methods for Wood Property Traits in Loblolly Pine and Hybrid Poplar; FINAL

    International Nuclear Information System (INIS)

    Tuskan, G.A.

    2001-01-01

    Wood properties influence pulp and paper quality. Certainly, overall pulp yields are directly related to the cellulose content, changes in hemicellulose content are associated with changes in pulp cohesiveness, and pulping efficiency is related to lignin content. Despite the importance of wood properties on product quality, little progress has been made in improving such traits because current methods of assessing wood and fiber characteristics are time-consuming, expensive, and often imprecise. Genetic improvement of wood and fiber properties has been further hampered by the large size of trees, delayed reproductive maturity and long harvest cycles. Recent developments in molecular genetics will help overcome the physical, economic and biological constraints in assessing and improving wood properties. Genetic maps consisting of numerous molecular markers are now available for loblolly pine and hybrid poplar. Such markers/maps may be used as part of a marker-aided selection and breeding effort or to expedite the isolation and characterization of genes and/or promoters that directly control wood properties. The objectives of this project are: (1) to apply new and rapid analytical techniques for assessing component wood properties to segregating F(sub 2) progeny populations of loblolly pine and hybrid poplar, (2) to map quantitative trait loci and identify molecular markers associated with wood properties in each of the above species and (3) to validate marker-aided selection methods for wood properties in loblolly pine and hybrid poplar

  19. Development and Validation of Marker-Aided Selection Methods for Wood Property Traits in Loblolly Pine and Hybrid Poplar

    Energy Technology Data Exchange (ETDEWEB)

    Tuskan, G.A.

    2001-06-20

    Wood properties influence pulp and paper quality. Certainly, overall pulp yields are directly related to the cellulose content, changes in hemicellulose content are associated with changes in pulp cohesiveness, and pulping efficiency is related to lignin content. Despite the importance of wood properties on product quality, little progress has been made in improving such traits because current methods of assessing wood and fiber characteristics are time-consuming, expensive, and often imprecise. Genetic improvement of wood and fiber properties has been further hampered by the large size of trees, delayed reproductive maturity and long harvest cycles. Recent developments in molecular genetics will help overcome the physical, economic and biological constraints in assessing and improving wood properties. Genetic maps consisting of numerous molecular markers are now available for loblolly pine and hybrid poplar. Such markers/maps may be used as part of a marker-aided selection and breeding effort or to expedite the isolation and characterization of genes and/or promoters that directly control wood properties. The objectives of this project are: (1) to apply new and rapid analytical techniques for assessing component wood properties to segregating F2 progeny populations of loblolly pine and hybrid poplar, (2) to map quantitative trait loci and identify molecular markers associated with wood properties in each of the above species and (3) to validate marker-aided selection methods for wood properties in loblolly pine and hybrid poplar.

  20. Resilient Design Properties in a Driverless Transport System

    DEFF Research Database (Denmark)

    Wied, Morten; Oehmen, Josef; Welo, Torgeir

    2018-01-01

    From its origin in ecology, resilient system properties have attracted wider interest for their applications to man-made systems. Previous research has shown that a simple conceptual model seems to capture much resilience thinking across disciplines and system types. In this paper, we apply...

  1. Early age fracture properties of microstructurally-designed mortars

    DEFF Research Database (Denmark)

    Di Bella, Carmelo; Michel, Alexander; Stang, Henrik

    2017-01-01

    This paper compares the fracture properties as well as crack initiation and propagation of real and equivalent mortars. The development of the elastic modulus, tensile strength, and fracture energy at different hydration stages were determined by inverse analysis of load-displacement curves...... the two mortars. At early age, the moisture content has a considerable influence on the tensile strength and the fracture energy....

  2. ENGINEERING DESIGN OPTIMIZATION OF HEEL TESTING EQUIPMENT IN THE EXPERIMENTAL VALIDATION OF SAFE WALKING

    Directory of Open Access Journals (Sweden)

    Cristiano Fragassa

    2017-06-01

    Full Text Available Experimental test methods for the evaluation of the resistance of heels of ladies' shoes in the case of impact loads are fully defined by International Organization for Standardization (ISO procedures that indicate all the conditions of experiment. A first Standard (ISO 19553 specifies the test method for determining the strength of the heels in the case of single impact. The result offers a valuation of the liability to fail under the sporadic heavy blows. A second Standard (ISO 19556 details a method for testing the capability of heels of women' shoes to survive to the repetition of small impacts provoked by normal walking. These Standards strictly define the features for two different testing devices (with specific materials, geometries, weights, etc. and all the experimental procedures to be followed during tests. On the contrary, this paper describes the technical solutions adopted to design one single experimental device able to perform impact testing of heels in both conditions. Joining the accuracy of mechanic movements with the speed of an electronic control system, a new and flexible equipment for the complete characterization of heels respect to (single or fatigue impacts was developed. Moreover a new level of performances in experimental validation of heel resistance was introduced by the versatility of the user-defined software control programs, able to encode every complex time-depending cycle of impact loads. Dynamic simulations permitted to investigate the impacts on heel in different conditions of testing, optimizing the machine design. The complexity of real stresses on shoes during an ordinary walk and in other common situations (as going up and downstairs was considered for a proper dimensioning.

  3. Design, development, and validation of a segment support actuator for the prototype segmented mirror telescope

    Science.gov (United States)

    Deshmukh, Prasanna Gajanan; Mandal, Amaresh; Parihar, Padmakar S.; Nayak, Dayananda; Mishra, Deepta Sundar

    2018-01-01

    Segmented mirror telescopes (SMT) are built using several small hexagonal mirrors positioned and aligned by the three actuators and six edge sensors per segment to maintain the shape of the primary mirror. The actuators are responsible for maintaining and tracking the mirror segments to the desired position, in the presence of external disturbances introduced by wind, vibration, gravity, and temperature. The present paper describes our effort to develop a soft actuator and the actuator controller for prototype SMT at Indian Institute of Astrophysics, Bangalore. The actuator designed, developed, and validated is a soft actuator based on the voice coil motor and flexural elements. It is designed for the range of travel of ±1.5 mm and the force range of 25 N along with an offloading mechanism to reduce the power consumption. A precision controller using a programmable system on chip (PSoC 5Lp) and a customized drive board has also been developed for this actuator. The close loop proportional-integral-derivative (PID) controller implemented in the PSoC gets position feedback from a high-resolution linear optical encoder. The optimum PID gains are derived using relay tuning method. In the laboratory, we have conducted several experiments to test the performance of the prototype soft actuator as well as the controller. We could achieve 5.73- and 10.15-nm RMS position errors in the steady state as well as tracking with a constant speed of 350 nm/s, respectively. We also present the outcome of various performance tests carried out when off-loader is in action as well as the actuator is subjected to dynamic wind loading.

  4. Validity and reliability of GPS and LPS for measuring distances covered and sprint mechanical properties in team sports.

    Science.gov (United States)

    Hoppe, Matthias W; Baumgart, Christian; Polglaze, Ted; Freiwald, Jürgen

    2018-01-01

    This study aimed to investigate the validity and reliability of global (GPS) and local (LPS) positioning systems for measuring distances covered and sprint mechanical properties in team sports. Here, we evaluated two recently released 18 Hz GPS and 20 Hz LPS technologies together with one established 10 Hz GPS technology. Six male athletes (age: 27±2 years; VO2max: 48.8±4.7 ml/min/kg) performed outdoors on 10 trials of a team sport-specific circuit that was equipped with double-light timing gates. The circuit included various walking, jogging, and sprinting sections that were performed either in straight-lines or with changes of direction. During the circuit, athletes wore two devices of each positioning system. From the reported and filtered velocity data, the distances covered and sprint mechanical properties (i.e., the theoretical maximal horizontal velocity, force, and power output) were computed. The sprint mechanical properties were modeled via an inverse dynamic approach applied to the center of mass. The validity was determined by comparing the measured and criterion data via the typical error of estimate (TEE), whereas the reliability was examined by comparing the two devices of each technology (i.e., the between-device reliability) via the coefficient of variation (CV). Outliers due to measurement errors were statistically identified and excluded from validity and reliability analyses. The 18 Hz GPS showed better validity and reliability for determining the distances covered (TEE: 1.6-8.0%; CV: 1.1-5.1%) and sprint mechanical properties (TEE: 4.5-14.3%; CV: 3.1-7.5%) than the 10 Hz GPS (TEE: 3.0-12.9%; CV: 2.5-13.0% and TEE: 4.1-23.1%; CV: 3.3-20.0%). However, the 20 Hz LPS demonstrated superior validity and reliability overall (TEE: 1.0-6.0%; CV: 0.7-5.0% and TEE: 2.1-9.2%; CV: 1.6-7.3%). For the 10 Hz GPS, 18 Hz GPS, and 20 Hz LPS, the relative loss of data sets due to measurement errors was 10.0%, 20.0%, and 15.8%, respectively. This study shows that

  5. Methodology for the nuclear design validation of an Alternate Emergency Management Centre (CAGE

    Directory of Open Access Journals (Sweden)

    Hueso César

    2017-01-01

    Full Text Available The methodology is devised by coupling different codes. The study of weather conditions as part of the data of the site will determine the relative concentrations of radionuclides in the air using ARCON96. The activity in the air is characterized depending on the source and release sequence specified in NUREG-1465 by RADTRAD code, which provides results of the inner cloud source term contribution. Known activities, energy spectra are inferred using ORIGEN-S, which are used as input for the models of the outer cloud, filters and containment generated with MCNP5. The sum of the different contributions must meet the conditions of habitability specified by the CSN (Spanish Nuclear Regulatory Body (TEDE <50 mSv and equivalent dose to the thyroid <500 mSv within 30 days following the accident doses so that the dose is optimized by varying parameters such as CAGE location, flow filtering need for recirculation, thicknesses and compositions of the walls, etc. The results for the most penalizing area meet the established criteria, and therefore the CAGE building design based on the methodology presented is radiologically validated.

  6. Methodology for the nuclear design validation of an Alternate Emergency Management Centre (CAGE

    Directory of Open Access Journals (Sweden)

    Hueso César

    2017-01-01

    Full Text Available The methodology is devised by coupling different codes. The study of weather conditions as part of the data of the site will determine the relative concentrations of radionuclides in the air using ARCON96. The activity in the air is characterized depending on the source and release sequence specified in NUREG-1465 by RADTRAD code, which provides results of the inner cloud source term contribution. Known activities and energy spectra are inferred using ORIGEN-S, which are used as input for the models of the outer cloud, filters and containment generated with MCNP5. The sum of the different contributions must meet the conditions of habitability specified by the CSN (Spanish Nuclear Regulatory Body (TEDE <50 mSv and equivalent dose to the thyroid <500 mSv within 30 days following the accident doses so that the dose is optimized by varying parameters including CAGE location, flow filtering need for recirculation, thicknesses and compositions of the walls, etc. The results for the most penalizing area meet the established criteria, and therefore the CAGE building design based on the methodology presented is radiologically validated.

  7. [Design and validation of a training model on paediatric and neonatal surgery].

    Science.gov (United States)

    Pérez-Duarte, F J; Díaz-Güemes, I; Sánchez-Hurtado, M A; Cano Novillo, I; Berchi García, F J; García Vázquez, A; Sánchez-Margallo, F M

    2012-07-01

    We present our experience in the design and development of a training program in paediatric and neonatal laparoscopic surgery, and the determination of face validity by the attendants. Data included in the present study was obtained from five consecutive editions of our Neonatal and Paediatric Laparoscopic Surgery Course. Our training model, with a total duration of 21 hours, begins with acquisition of knowledge in ergonomics and instrument concepts, after which the attendants develop basic laparoscopic dexterity through the performance of hands-on physical simulator tasks. During the second and third days of the course, surgeons undertook various surgical techniques hands-on animal model. At the end of the training program, a subjective evaluation questionnaire was handed out to the attendants, in which different didactic and organizational aspects were considered. We obtained a highly positive score on all questions concerning the different topics and techniques included in the training program (> or = 9 points over 10). 78,5% of the 54 attendants was in accordance with the course total duration, whilst 21,5% considered that it should be of longer duration. Regarding abilities' self assessment, 79,1% considered themselves capacitated to perform trained procedures on live patients. The presented training model has obtained a very positive valuation score, leading to an increase in the attendants' self confidence in the application of learned techniques to their clinical practice.

  8. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments

    Science.gov (United States)

    Abdel-Aziz, Omar; Ayad, Miriam F.; Tadros, Mariam M.

    2015-04-01

    Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 μg ml-1. The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 μg ml-1. The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 μg ml-1. All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms.

  9. Design and validation of a highly discriminatory 10-locus Y-chromosome STR multiplex system

    KAUST Repository

    D'Amato, María Eugenia

    2011-03-01

    The Y-chromosome STRs (short tandem repeat) markers are routinely utilized in the resolution of forensic casework related to sexual assault. For this, the forensic community has adopted a set of eleven (core) Y-STR that is incorporated in all commercial diagnostic systems. Our previous studies of Y-STR polymorphisms in the South African population identified low levels of diversity and discrimination capacity for many commercial marker sets, determining a limited applicability of these systems to the local population groups. To overcome this shortcoming, we designed a Y-STR 10-plex system that shows higher discriminatory capacity (DC) than available commercial systems. The markers were selected from a population group of 283 individuals with African, European and Asian ancestry genotyped at 45 Y-STRs, applying an optimization based selection procedure to achieve the highest possible DC with the minimal number of markers. The 10-plex was satisfactorily subjected to developmental validation tests following the SWGDAM guidelines and shows potential for its application to genealogical and evolutionary studies. © 2010 Elsevier Ireland Ltd.

  10. Evaluation of musical language in grownup students: Design and validation of a scale.

    Directory of Open Access Journals (Sweden)

    Ana Mercedes Vernia Carrasco

    2018-01-01

    Full Text Available Musical language organizes general musical training in conservatories and music schools, becoming an attractive, active and dynamic way of learning music, often including rhythmic, body and game activities, and didactic elements such as songs, dance and musical listening. In the case of adult learners, teaching musical language must adapt to psychosocial characteristics of this group. This paper aims to design, validate and apply an instrument shaped as a rubric to evaluate musical language performance in a sample of adult students, based on specific analysis of documents. Scale contains 21 activities that evaluate four skills. The results confirm that there are four main items that would explain most of the academic achievement in musical language in adults: to recognize melodic and harmonic intervals, internalizing tempo, musical dictation and vocal creation, with preparation. Likewise, the results allow to raise a teaching methodology that combines perceptive, corporal, symbolic and communicative aspects in this subject, updating and consolidating the present orientation that teaching has gradually taken.

  11. Designing and Assessing the Validity and Reliability of the Hospital Readiness Assessment Tools to Conducting Quality Improvement Program

    Directory of Open Access Journals (Sweden)

    Kamal Gholipoor

    2016-09-01

    Full Text Available Background and objectives : Identifying the readiness of hospital and its strengths and weaknesses can be useful in developing appropriate planning and situation analyses and management to getting effective in clinical audit programs. The aim of this study was to design and assess the validity of the Hospital Readiness Assessment Tools to conduct quality improvement and clinical audit programs. Material and Methods: In this study, based on the results of a systematic review of literature, an initial questionnaire with 77 items was designed. Questionnaire content validity was reviewed by experts in the field of hospital management and quality improvement in Tabriz University of Medical Sciences. For this purpose, 20 questionnaires were sent to experts. Finally, 15 participants returned completed questionnaire. Questionnaire validity was reviewed and confirmed based on Content Validity Index and Content Validity Ratio. Questionnaire reliability was confirmed based on Cronbach's alpha index (α = 0.96 in a pilot study by participation of 30 hospital managers. Results: The results showed that the final questionnaire contains 54 questions as nine category as: data and information (9 items, teamwork (12 questions, resources (5 questions, patient and education (5, intervention design and implementation (5 questions, clinical audit management (4 questions, human resources (6 questions, evidence and standard (4 items and evaluation and feedback (4 items. The final questionnaire content validity index was 0.91 and final questionnaire Cronbach's alpha coefficient was 0.96. Conclusion: Considering the relative good validity and reliability of the designed tool in this study, it appears that the questionnaire can be used to identify and assess the readiness of hospitals for quality improvement and clinical audit program implementation

  12. Development, validation and psychometric properties of a diagnostic/prognostic tool for breakthrough pain in mixed chronic-pain patients.

    Science.gov (United States)

    Samolsky Dekel, Boaz Gedaliahu; Remondini, Francesca; Gori, Alberto; Vasarri, Alessio; Di Nino, GianFranco; Melotti, Rita Maria

    2016-02-01

    Breakthrough pain (BTP) shows variable prevalence in different clinical contexts of cancer and non-cancer patients. BTP diagnostic tools with demonstrated reliability, validation and prognostic capability are lacking. We report the development, psychometric and validation properties of a diagnostic/prognostic tool, the IQ-BTP, for BTP recognition, its likelihood and clinical features among chronic-pain (CP) patients. n=120 consecutive mixed cancer/non-cancer CP in/outpatients. Development, psychometric analyses and formal validation included: Face/Content validity (by 'experts' opinion and assessing the relationship between the IQ-BTP classes and criteria derived from BTP operational-case-definition); Construct validity, by Principle Component Analysis (PCA); and the strength of Spearman correlation between IQ-BTP classes and the Brief Pain Inventory (BPI) items; Reliability, by Cronbach's alpha statistics. Associations with clinical/demographic moderators were assessed applying χ(2) analysis. Potential-BTP was found in 36.7% of patients (38.4% of non-cancer and 32.4% of cancer patients). Among these the likelihood for BTP diagnosis was 'high' in 25%, 'intermediate' in 41% and, 'low' 34% of patients. Analyses showed significant differences between IQ-BTP classes and between the latter BPI pain-item scores. Correlation between IQ-BTP classes and BPI items was moderate. PCA and scree test identified 3 components accounting for 62.3% of the variance. Cronbach's alpha was 0.71. The IQ-BTP showed satisfactory psychometric and validation properties. With adequate feasibility it enabled the allocating of cancer/non-cancer CP patients in three prognostic classes. Results are sufficient to warrant a subsequent impact study of the IQ-BTP as prognostic model and screening tool for BTP in both CP populations. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Measuring Gambling Reinforcers, Over Consumption and Fallacies: The Psychometric Properties and Predictive Validity of the Jonsson-Abbott Scale

    Directory of Open Access Journals (Sweden)

    Jakob Jonsson

    2017-10-01

    Full Text Available Traditionally, gambling and problem gambling research relies on cross-sectional and retrospective designs. This has compromised identification of temporal relationships and causal inference. To overcome these problems a new questionnaire, the Jonsson-Abbott Scale (JAS, was developed and used in a large, prospective, general population study, The Swedish Longitudinal Gambling Study (Swelogs. The JAS has 11 items and seeks to identify early indicators, examine relationships between indicators and assess their capacity to predict future problem progression. The aims of the study were to examine psychometric properties of the JAS (internal consistency and dimensionality and predictive validity with respect to increased gambling risk and problem gambling onset. The results are based on repeated interviews with 3818 participants. The response rate from the initial baseline wave was 74%. The original sample consisted of a random, stratified selection from the Swedish population register aged between 16 and 84. The results indicate an acceptable fit of a three-factor solution in a confirmatory factor analysis with ‘Over consumption,’ ‘Gambling fallacies,’ and ‘Reinforcers’ as factors. Reinforcers, Over consumption and Gambling fallacies were significant predictors of gambling risk potential and Gambling fallacies and Over consumption were significant predictors of problem gambling onset (incident cases at 12 month follow up. When controlled for risk potential measured at baseline, the predictor Over consumption was not significant for gambling risk potential at follow up. For incident cases, Gambling fallacies and Over consumption remained significant when controlled for risk potential. Implications of the results for the development of problem gambling, early detection, prevention, and future research are discussed.

  14. Measuring Gambling Reinforcers, Over Consumption and Fallacies: The Psychometric Properties and Predictive Validity of the Jonsson-Abbott Scale.

    Science.gov (United States)

    Jonsson, Jakob; Abbott, Max W; Sjöberg, Anders; Carlbring, Per

    2017-01-01

    Traditionally, gambling and problem gambling research relies on cross-sectional and retrospective designs. This has compromised identification of temporal relationships and causal inference. To overcome these problems a new questionnaire, the Jonsson-Abbott Scale (JAS), was developed and used in a large, prospective, general population study, The Swedish Longitudinal Gambling Study (Swelogs). The JAS has 11 items and seeks to identify early indicators, examine relationships between indicators and assess their capacity to predict future problem progression. The aims of the study were to examine psychometric properties of the JAS (internal consistency and dimensionality) and predictive validity with respect to increased gambling risk and problem gambling onset. The results are based on repeated interviews with 3818 participants. The response rate from the initial baseline wave was 74%. The original sample consisted of a random, stratified selection from the Swedish population register aged between 16 and 84. The results indicate an acceptable fit of a three-factor solution in a confirmatory factor analysis with 'Over consumption,' 'Gambling fallacies,' and 'Reinforcers' as factors. Reinforcers, Over consumption and Gambling fallacies were significant predictors of gambling risk potential and Gambling fallacies and Over consumption were significant predictors of problem gambling onset (incident cases) at 12 month follow up. When controlled for risk potential measured at baseline, the predictor Over consumption was not significant for gambling risk potential at follow up. For incident cases, Gambling fallacies and Over consumption remained significant when controlled for risk potential. Implications of the results for the development of problem gambling, early detection, prevention, and future research are discussed.

  15. STUDY ON THE REASONABLE EVALUATION OF SOIL PROPERTIES APPLIED IN THE DESIGN OF SHINSO FOUNDATION (JAPANESE STYLE CAISSON TYPE PILE) ON THE SLOPE

    Science.gov (United States)

    Yasuzato, Toshinori; Samizo, Junichi; Maeda, Yoshito; Abe, Tetsuo; Matsuki, Satoshi; Okutani, Junpei

    The objective of this study is to find ways to maximize the design economy of the shinso foundation (Japanese style caisson type pile) on the rock slope through an evaluation of strength properties of the rock before and after plasticity. We investigate the influence of soil properties on the design result by carrying out experiments which give the soil properties before and after plasticity and by doing parametric studies on the soil properties. Experiment using small-scale shinso foundation is performed to verify the validity of result of examinations. Comparison between the experiment and the analytical result reveals the bearing capacity characteristics of the shinso foundation on the slope and gives new insights on the more economical design of the shinso foundation.

  16. Characterizing problematic hypoglycaemia: iterative design and preliminary psychometric validation of the Hypoglycaemia Awareness Questionnaire (HypoA-Q).

    Science.gov (United States)

    Speight, J; Barendse, S M; Singh, H; Little, S A; Inkster, B; Frier, B M; Heller, S R; Rutter, M K; Shaw, J A M

    2016-03-01

    To design and conduct preliminary validation of a measure of hypoglycaemia awareness and problematic hypoglycaemia, the Hypoglycaemia Awareness Questionnaire. Exploratory and cognitive debriefing interviews were conducted with 17 adults (nine of whom were women) with Type 1 diabetes (mean ± sd age 48 ± 10 years). Questionnaire items were modified in consultation with diabetologists/psychologists. Psychometric validation was undertaken using data from 120 adults (53 women) with Type 1 diabetes (mean ± sd age 44 ± 16 years; 50% with clinically diagnosed impaired awareness of hypoglycaemia), who completed the following questionnaires: the Hypoglycaemia Awareness Questionnaire, the Gold score, the Clarke questionnaire and the Problem Areas in Diabetes questionnaire. Iterative design resulted in 33 items eliciting responses about awareness of hypoglycaemia when awake/asleep and hypoglycaemia frequency, severity and impact (healthcare utilization). Psychometric analysis identified three subscales reflecting 'impaired awareness', 'symptom level' and 'symptom frequency'. Convergent validity was indicated by strong correlations between the 'impaired awareness' subscale and existing measures of awareness: (Gold: rs =0.75, P Questionnaire has robust face and content validity; satisfactory structure; internal reliability; convergent, divergent and known groups validity. The impaired awareness subscale and other items contribute significantly to models explaining recall of severe and nocturnal hypoglycaemia. Prospective validation, including determination of a threshold to identify impaired awareness, is now warranted. © 2015 The Authors. Diabetic Medicine © 2015 Diabetes UK.

  17. [Design and validation of a questionnaire exploring risky-driving patterns in young drivers].

    Science.gov (United States)

    Jiménez Mejías, Eladio; Luna del Castillo, Juan de Dios; Amezcua Prieto, Carmen; Olvera Porcel, María Carmen; Lardelli Claret, Pablo; Jiménez Moleón, José Juan

    2012-01-01

    Traffic Injuries are a major public health problem, especially among young people. However, we have not found any useful questionnaire designed in our country for the epidemiological research in this field. The objective of this study was to design and validate an easy and quickly-to-fill questionnaire aimed to collect information on how frequently university car drivers report to be involved in driving circumstances theoretically related to traffic crashes. Between 2007 and 2010, a total of 1597 young undergraduate students at the University of Granada answered a self-administered questionnaire collecting information about exposure, accidents and involvement in 28 different driving circumstances. For designing this questionnaire, an extensive literature review was carried out and the opinions of five experts in a panel were also taken into account. By applying the tetracoric correlation coefficient, we conducted a factor analysis. Internal consistency was assessed using Cronbach's alpha coefficient. Finally, we evaluated the crude and adjusted association of each identified factor with the odds for having suffered an accident. After excluding 8 circumstances, the remaining ones were grouped into three factors: the first one included ten high-prevalence circumstances and explained 31.9% of the total variability. Meanwhile, the other two factors included five circumstances each one which respectively explained 15.2% and 12.5% of the variability. Cronbach's alpha coefficients ranged between 0.816 and 0.553. When adjustments according age, sex, years in possession of the driving license and intensity of exposure were made, the first factor obtained the score more strongly associated with the accident rate (OR = 1.51; CI95%: 1.25-1.85). The final version (20 circumstances) identified three factors related to higher accident rates among the young drivers. The first one integrated, among other circumstances, the excessive speed and driving while sleepy or tired and it

  18. The Piracy Paradox: Innovation and Intellectual Property in Fashion Design

    OpenAIRE

    Sprigman, Chris; Raustiala, K

    2006-01-01

    The orthodox justification for intellectual property is utilitarian. Advocates for strong IP rights argue that absent such rights copyists will free-ride on the efforts of creators and stifle innovation. This orthodox justification is logically straightforward and well reflected in the law. Yet a significant empirical anomaly exists: the global fashion industry, which produces a huge variety of creative goods without strong IP protection. Copying is rampant as the orthodox account would predi...

  19. The TALL-3D facility design and commissioning tests for validation of coupled STH and CFD codes

    Energy Technology Data Exchange (ETDEWEB)

    Grishchenko, Dmitry, E-mail: dmitry@safety.sci.kth.se; Jeltsov, Marti, E-mail: marti@safety.sci.kth.se; Kööp, Kaspar, E-mail: kaspar@safety.sci.kth.se; Karbojian, Aram, E-mail: karbojan@kth.se; Villanueva, Walter, E-mail: walter@safety.sci.kth.se; Kudinov, Pavel, E-mail: pavel@safety.sci.kth.se

    2015-08-15

    Highlights: • Design of a heavy liquid thermal-hydraulic loop for CFD/STH code validation. • Description of the loop instrumentation and assessment of measurement error. • Experimental data from forced to natural circulation transient. - Abstract: Application of coupled CFD (Computational Fluid Dynamics) and STH (System Thermal Hydraulics) codes is a prerequisite for computationally affordable and sufficiently accurate prediction of thermal-hydraulics of complex systems. Coupled STH and CFD codes require validation for understanding and quantification of the sources of uncertainties in the code prediction. TALL-3D is a liquid Lead Bismuth Eutectic (LBE) loop developed according to the requirements for the experimental data for validation of coupled STH and CFD codes. The goals of the facility design are to provide (i) mutual feedback between natural circulation in the loop and complex 3D mixing and stratification phenomena in the pool-type test section, (ii) a possibility to validate standalone STH and CFD codes for each subsection of the facility, and (iii) sufficient number of experimental data to separate the process of input model calibration and code validation. Description of the facility design and its main components, approach to estimation of experimental uncertainty and calibration of model input parameters that are not directly measured in the experiment are discussed in the paper. First experimental data from the forced to natural circulation transient is also provided in the paper.

  20. Development, validation and psychometric properties of the Arabic version of the Orofacial Esthetic Scale: OES-Ar.

    Science.gov (United States)

    Alhajj, Mohammed Nasser; Amran, Abdullah Ghalib; Halboub, Esam; Al-Basmi, Abdulghani Ali; Al-Ghabri, Fawaz Abdullah

    2017-07-01

    This study aimed at developing the Arabic version of the Orofacial Esthetic Scale (OES-Ar) and to investigate its psychometric properties among Arabic-speaking population with and without esthetic impairments. Translation and cross-cultural adaptation was done according to the standard guidelines. Internal consistency was assessed on 230 participants. For test-retest reliability, 50 subjects with natural teeth were recalled within a period of 2 weeks. Validity of the OES-Ar was tested by construct, convergent, and discriminant validity tests. Responsiveness to esthetic changes was assessed in 60 patients. The results showed excellent internal consistency with Cronbach's alpha value of 0.92 and inter-item correlation average value of 0.60. The ICC values ranged from 0.87 to 0.96 which indicated excellent agreement. Construct validity of the OES-Ar was confirmed to be one-factor structure (one-dimensional). For convergent validity, a significant correlation was found between OES summary score and overall impression of the orofacial esthetic as well as between OES summary score and the summary score of the three questions of the OHIP-49Ar related to esthetic. The discriminant validity test revealed significant differences between different study groups (Pesthetics in Arabic-speaking patients. Copyright © 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  1. Validation Studies for Numerical Simulations of Flow Phenomena Expected in the Lower Plenum of a Prismatic VHTR Reference Design

    International Nuclear Information System (INIS)

    Richard W. Johnson

    2005-01-01

    The final design of the very high temperature reactor (VHTR) of the fourth generation of nuclear power plants (Gen IV) has not yet been established. The VHTR may be either a prismatic (block) or pebble bed type. It may be either gas-cooled or cooled with an as yet unspecified molten salt. However, a conceptual design of a gas-cooled VHTR, based on the General Atomics GT-MHR, does exist and is called the prismatic VHTR reference design, MacDonald et al [2003], General Atomics [1996]. The present validation studies are based on the prismatic VHTR reference design. In the prismatic VHTR reference design, the flow in the lower plenum will be introduced by dozens of turbulent jets issuing into a large crossflow that must negotiate dozens of cylindrical support columns as it flows toward the exit duct of the reactor vessel. The jets will not all be at the same temperature due to the radial variation of power density expected in the core. However, it is important that the coolant be well mixed when it enters the power conversion unit to ensure proper operation and long life of the power conversion machinery. Hence, it is deemed important to be able to accurately model the flow and mixing of the variable temperature coolant in the lower plenum and exit duct. Accurate flow modeling involves determining modeling strategies including the fineness of the grid needed, iterative convergence tolerance, numerical discretization method used, whether the flow is steady or unsteady, and the turbulence model and wall treatment employed. It also involves validation of the computer code and turbulence model against a series of separate and combined flow phenomena and selection of the data used for the validation. The present report describes progress made to date for the task entitled ''CFD software validation of jets in crossflow'' which was designed to investigate the issues pertaining to the validation process

  2. Design and validation of standardized clinical and functional remission criteria in schizophrenia

    Directory of Open Access Journals (Sweden)

    Mosolov SN

    2014-01-01

    Full Text Available Sergey N Mosolov,1 Andrey V Potapov,1 Uriy V Ushakov,2 Aleksey A Shafarenko,1 Anastasiya B Kostyukova11Department of Mental Disorders Therapy, Moscow Research Institute of Psychiatry, Moscow, Russia; 2Moscow Psychiatric Outpatient Services #21, Moscow, RussiaBackground: International Remission Criteria (IRC for schizophrenia were developed recently by a group of internationally known experts. The IRC detect only 10%–30% of cases and do not cover the diversity of forms and social functioning. Our aim was to design a more applicable tool and validate its use – the Standardized Clinical and Functional Remission Criteria (SCFRC.Methods: We used a 6-month follow-up study of 203 outpatients from two Moscow centers and another further sample of stable patients from a 1-year controlled trial of atypical versus typical medication. Diagnosis was confirmed by International Classification of Diseases Version 10 (ICD10 criteria and the Mini-International Neuropsychiatric Interview (MINI. Patients were assessed by the Positive and Negative Syndrome Scale, including intensity threshold, and further classified using the Russian domestic remission criteria and the level of social and personal functioning, according to the Personal and Social Performance Scale (PSP. The SCFRC were formulated and were validated by a data reanalysis on the first population sample and on a second independent sample (104 patients and in an open-label prospective randomized 12-month comparative study of risperidone long-acting injectable (RLAI versus olanzapine.Results: Only 64 of the 203 outpatients (31.5% initially met the IRC, and 53 patients (26.1% met the IRC after 6 months, without a change in treatment. Patients who were in remission had episodic and progressive deficit (39.6%, or remittent (15% paranoid schizophrenia, or schizoaffective disorder (17%. In addition, 105 patients of 139 (51.7%, who did not meet symptomatic IRC, remained stable within the period. Reanalysis of

  3. Computational Design of Creep-Resistant Alloys and Experimental Validation in Ferritic Superalloys

    Energy Technology Data Exchange (ETDEWEB)

    Liaw, Peter

    2014-12-31

    A new class of ferritic superalloys containing B2-type zones inside parent L21-type precipitates in a disordered solid-solution matrix, also known as a hierarchical-precipitate strengthened ferritic alloy (HPSFA), has been developed for high-temperature structural applications in fossil-energy power plants. These alloys were designed by the addition of the Ti element into a previously-studied NiAl-strengthened ferritic alloy (denoted as FBB8 in this study). In the present research, systematic investigations, including advanced experimental techniques, first-principles calculations, and numerical simulations, have been integrated and conducted to characterize the complex microstructures and excellent creep resistance of HPSFAs. The experimental techniques include transmission-electron microscopy, scanningtransmission- electron microscopy, neutron diffraction, and atom-probe tomography, which provide detailed microstructural information of HPSFAs. Systematic tension/compression creep tests revealed that HPSFAs exhibit the superior creep resistance, compared with the FBB8 and conventional ferritic steels (i.e., the creep rates of HPSFAs are about 4 orders of magnitude slower than the FBB8 and conventional ferritic steels.) First-principles calculations include interfacial free energies, anti-phase boundary (APB) free energies, elastic constants, and impurity diffusivities in Fe. Combined with kinetic Monte- Carlo simulations of interdiffusion coefficients, and the integration of computational thermodynamics and kinetics, these calculations provide great understanding of thermodynamic and mechanical properties of HPSFAs. In addition to the systematic experimental approach and first-principles calculations, a series of numerical tools and algorithms, which assist in the optimization of creep properties of ferritic superalloys, are utilized and developed. These numerical simulation results are compared with the available experimental data and previous first

  4. Capability of APROS in design and validation of I and C systems

    International Nuclear Information System (INIS)

    Kantee, H.; Porkholm, K.

    2004-01-01

    There are two WWER-440 type reactors in Loviisa. The first unit was commissioned in 1977 and the second in 1980. The availability of the plant as well as the operational experiences of the Instrumentation and control systems are good. However, it is obvious that the lifetime of the original I and C systems is not sufficient to guarantee the good availability of the plant in the future. Due to this fact a project for the renewal of the existing I and C systems has been started at Loviisa Nuclear Power Plant (NPP). In the project the analog I and C systems will be replaced with a digital I and C systems in four phases during from 2006-2014. Simulators will be utilized extensively in the project to assure that the renewal of I and C systems can be realized safely and economically. The engineering simulator will be used in the design and validation of the modernized I and C systems. The development simulator is aimed for the design, testing and acceptance of the new Man Machine Interface (MMI). The testing simulator will used for the testing of the new I and C systems and for retuning of the controllers mainly during the Factory Acceptance Tests. The training simulator will be used to familiarize the operators and other technical personnel to the operation of the new monitor-based control room facilities. APROS simulation software will be the main simulation tool in development and assessing of the new I and C configuration as well as in training of the plant personnel. First a brief description of the APROS code and APROS model of Loviisa plant including the model validation extent is discussed. Then the development and design of the new I and C system of Loviisa NPP is presented. As an example the application where trip of three reactor coolant pumps (RCP) assuming different failures during the transient is presented. An essential APROS feature in this study is the capability of the code to simulate the control rod movement. This feature is needed especially in WWER

  5. The iSAT Project Mechanical properties and designs

    KAUST Repository

    Llewellyn, Gareth

    2011-08-08

    The whale shark Rhincodon typus is the largest fish in the world. The global population of R.typus is unknown however the International Union for Conservation of Nature (IUNC) classified it as Vulnerable in 2005. To ensure a population of R.typus is maintained protection from direct fishing, by-catch and collision damage is required. To be able to enact successful protection the habitat and range of R.typus must be known. Many authors have conducted studies of R.typus in a variety of different locations and many more have reported sightings. In many locations R.typus consistently appear annually and many authors have hypothesised reasons for their appearance. What is not known however is whether these populations are isolated or inter-linked, and where these populations go when they are not at known sites. The aim of this thesis was to design the body of a vessel that could house the electronics and components designed to track an acoustic tag, survive in open ocean, and travel fast enough to keep up with R.typus allowing a long-term and high resolution track to be compiled. In order to design such a vessel many factors needed to be known. A large part of this thesis is a review of literature to conclude the most appropriate type of vessel, the average speed of R.typus, hence the required speed of the vessel, and the sea state of the Red Sea, hence the conditions the vessel would be required to survive in. It was concluded that the average speed of R.typus is 1.2 knots; the Red Sea reaches Sea State 5-6; and the most appropriate hull type for this project was a Small Waterplane Area Twin Hull (SWATH). After following a design iteration process, a final design was completed that it is believed will achieve all the required objectives.

  6. Design and Validation of a Photographic Expressive Persian Grammar Test for Children Aged 4-6 Years

    Science.gov (United States)

    Haresabadi, Fatemeh; Ebadi, Abbas; Shirazi, Tahereh Sima; Dastjerdi Kazemi, Mehdi

    2016-01-01

    Syntax has a high importance among linguistic parameters, and syntax-related problems are the most common in language disorders. Therefore, the present study aimed to design a Photographic Expressive Persian Grammar Test for Iranian children in the age group of 4-6 years and to determine its validity and reliability. First, the target…

  7. Design and Validation of a Rubric to Assess the Use of American Psychological Association Style in Scientific Articles

    Science.gov (United States)

    Merma Molina, Gladys; Peña Alfaro, Hilda; Peña Alfaro González, Silvia Rosa

    2017-01-01

    In this study, the researchers will explore the process of designing and validating a rubric to evaluate the adaptation of scientific articles in the format of the "American Psychological Association" (APA). The rubric will evaluate certain aspects of the APA format that allow authors, editors, and evaluators to decide if the scientific…

  8. An assessment of the validity of inelastic design analysis methods by comparisons of predictions with test results

    International Nuclear Information System (INIS)

    Corum, J.M.; Clinard, J.A.; Sartory, W.K.

    1976-01-01

    The use of computer programs that employ relatively complex constitutive theories and analysis procedures to perform inelastic design calculations on fast reactor system components introduces questions of validation and acceptance of the analysis results. We may ask ourselves, ''How valid are the answers.'' These questions, in turn, involve the concepts of verification of computer programs as well as qualification of the computer programs and of the underlying constitutive theories and analysis procedures. This paper addresses the latter - the qualification of the analysis methods for inelastic design calculations. Some of the work underway in the United States to provide the necessary information to evaluate inelastic analysis methods and computer programs is described, and typical comparisons of analysis predictions with inelastic structural test results are presented. It is emphasized throughout that rather than asking ourselves how valid, or correct, are the analytical predictions, we might more properly question whether or not the combination of the predictions and the associated high-temperature design criteria leads to an acceptable level of structural integrity. It is believed that in this context the analysis predictions are generally valid, even though exact correlations between predictions and actual behavior are not obtained and cannot be expected. Final judgment, however, must be reserved for the design analyst in each specific case. (author)

  9. Design and validation of a critical pathway for hospital management of patients with severe traumatic brain injury.

    Science.gov (United States)

    Espinosa-Aguilar, Amilcar; Reyes-Morales, Hortensia; Huerta-Posada, Carlos E; de León, Itzcoatl Limón-Pérez; López-López, Fernando; Mejía-Hernández, Margarita; Mondragón-Martínez, María A; Calderón-Téllez, Ligia M; Amezcua-Cuevas, Rosa L; Rebollar-González, Jorge A

    2008-05-01

    Critical pathways for the management of patients with severe traumatic brain injury (STBI) may contribute to reducing the incidence of hospital complications, length of hospitalization stay, and cost of care. Such pathways have previously been developed for departments with significant resource availability. In Mexico, STBI is the most important cause of complications and length of stay in neurotrauma services at public hospitals. Although current treatment is designed basically in accordance with the Brain Trauma Foundation guidelines, shortfalls in the availability of local resources make it difficult to comply with these standards, and no critical pathway is available that accords with the resources of public hospitals. The purpose of the present study was to design and to validate a critical pathway for managing STBI patients that would be suitable for implementation in neurotrauma departments of middle-income level countries. The study comprised two phases: design (through literature review and design plan) and validation (content, construct, and appearance) of the critical pathway. The validated critical pathway for managing STBI patients entails four sequential subprocesses summarizing the hospital's care procedures, and includes three components: (1) nodes and criteria (in some cases, indicators are also included); (2) health team members in charge of the patient; (3) maximum estimated time for compliance with recommendations. This validated critical pathway is based on the current scientific evidence and accords with the availability of resources of middle-income countries.

  10. Development of basic technology for instrumentation and control - Development of digital automatic supervisory limitation system and its design= validation

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jung In; Chung, Sung Wook; Koh, Won Seok [Kyungwon University, Sungman (Korea, Republic of); Suh, Duk Young; Cheon, Sei Young [Kyunghee University, Seoul (Korea, Republic of); Lee, Sang Kyung; Kim, Sung Hun [Seoul National University, Seoul (Korea, Republic of)

    1995-07-01

    A major objective of the project is to develop a digital automatic supervisory limitation system and validate its design for the next generation= nuclear power plant. The limitation system assures that the plant does not exceed the operating limits by regulation the plant operations through on-line monitoring the operating margins of the critical parameters. A new conceptual model of power maneuverability has been proposed for the design of the limitation system and for its validation. Also, the limitation system monitors overall operation processes throughout a nuclear power plant by implementing hierarchical communication networks. Based on the conceptual design in software of the 1 st year results, the detailed design of the limitation system has been performed during the 2 nd year with constructing a prototype digital system. The system consists of the software module for plant simulation and the hardware module for implementation of limitation system and the associated interfaces in hardware. The limitation algorithm were implemented into the microprocessor and the interfaces were realized through the I/O modules. Also, these modules are incorporated into the communication networks. The products of the project could be directly applicable to the following nuclear unit adopting the limitation system, providing the bumpless transition to the commercial design phase. And the prototype evaluation scheme will be very useful for the succeeding studies related to the digital nuclear I and C fields, such as fault-tolerance design methods, software verification and validation and response time execution of digital systems. 69 refs., 3 tabs., 44 figs. (author)

  11. Development and Validation of Improved Techniques for Cloud Property Retrieval from Environmental Satellites

    National Research Council Canada - National Science Library

    Gustafson, Gary

    2000-01-01

    ...) develop extensible cloud property retrieval algorithms suitable for expanding existing cloud analysis capabilities to utilize data from new and future environmental satellite sensing systems; (2...

  12. An Improved FFR Design with a Ventilation Fan: CFD Simulation and Validation.

    Science.gov (United States)

    Zhang, Xiaotie; Li, Hui; Shen, Shengnan; Rao, Yu; Chen, Feng

    2016-01-01

    This article presents an improved Filtering Facepiece Respirator (FFR) designed to increase the comfort of wearers during low-moderate work. The improved FFR aims to lower the deadspace temperature and CO2 level by an active ventilation fan. The reversing modeling is used to build the 3D geometric model of this FFR; the Computational Fluid Dynamics (CFD) simulation is then introduced to investigate the flow field. Based on the simulation result, the ventilation fan of the improved FFR can fit the flow field well when placed in the proper blowing orientation; streamlines from this fan show a cup-shape distribution and are perfectly matched to the shape of the FFR and human face when the fan blowing inward. In the deadspace of the improved FFR, the CO2 volume fraction is controlled by the optimized flow field. In addition, an experimental prototype of the improved FFR has been tested to validate the simulation. A wireless temperature sensor is used to detect the temperature variation inside the prototype FFR, deadspace temperature is lowered by 2 K compared to the normal FFR without a fan. An infrared camera (IRC) method is used to elucidate the temperature distribution on the prototype FFR's outside surface and the wearer's face, surface temperature is lowered notably. Both inside and outside temperature results from the simulation are in agreement with experimental results. Therefore, adding an inward-blowing fan on the outer surface of an N95 FFR is a feasible approach to reducing the deadspace CO2 concentration and improve temperature comfort.

  13. DC microgrid power flow optimization by multi-layer supervision control. Design and experimental validation

    International Nuclear Information System (INIS)

    Sechilariu, Manuela; Wang, Bao Chao; Locment, Fabrice; Jouglet, Antoine

    2014-01-01

    Highlights: • DC microgrid (PV array, storage, power grid connection, DC load) with multi-layer supervision control. • Power balancing following power flow optimization while providing interface for smart grid communication. • Optimization under constraints: storage capability, grid power limitations, grid time-of-use pricing. • Experimental validation of DC microgrid power flow optimization by multi-layer supervision control. • DC microgrid able to perform peak shaving, to avoid undesired injection, and to make full use of locally energy. - Abstract: Urban areas have great potential for photovoltaic (PV) generation, however, direct PV power injection has limitations for high level PV penetration. It induces additional regulations in grid power balancing because of lacking abilities of responding to grid issues such as reducing grid peak consumption or avoiding undesired injections. The smart grid implementation, which is designed to meet these requirements, is facilitated by microgrids development. This paper presents a DC microgrid (PV array, storage, power grid connection, DC load) with multi-layer supervision control which handles instantaneous power balancing following the power flow optimization while providing interface for smart grid communication. The optimization takes into account forecast of PV power production and load power demand, while satisfying constraints such as storage capability, grid power limitations, grid time-of-use pricing and grid peak hour. Optimization, whose efficiency is related to the prediction accuracy, is carried out by mixed integer linear programming. Experimental results show that the proposed microgrid structure is able to control the power flow at near optimum cost and ensures self-correcting capability. It can respond to issues of performing peak shaving, avoiding undesired injection, and making full use of locally produced energy with respect to rigid element constraints

  14. Design and validation of a general purpose robotic testing system for musculoskeletal applications.

    Science.gov (United States)

    Noble, Lawrence D; Colbrunn, Robb W; Lee, Dong-Gil; van den Bogert, Antonie J; Davis, Brian L

    2010-02-01

    Orthopaedic research on in vitro forces applied to bones, tendons, and ligaments during joint loading has been difficult to perform because of limitations with existing robotic simulators in applying full-physiological loading to the joint under investigation in real time. The objectives of the current work are as follows: (1) describe the design of a musculoskeletal simulator developed to support in vitro testing of cadaveric joint systems, (2) provide component and system-level validation results, and (3) demonstrate the simulator's usefulness for specific applications of the foot-ankle complex and knee. The musculoskeletal simulator allows researchers to simulate a variety of loading conditions on cadaver joints via motorized actuators that simulate muscle forces while simultaneously contacting the joint with an external load applied by a specialized robot. Multiple foot and knee studies have been completed at the Cleveland Clinic to demonstrate the simulator's capabilities. Using a variety of general-use components, experiments can be designed to test other musculoskeletal joints as well (e.g., hip, shoulder, facet joints of the spine). The accuracy of the tendon actuators to generate a target force profile during simulated walking was found to be highly variable and dependent on stance position. Repeatability (the ability of the system to generate the same tendon forces when the same experimental conditions are repeated) results showed that repeat forces were within the measurement accuracy of the system. It was determined that synchronization system accuracy was 6.7+/-2.0 ms and was based on timing measurements from the robot and tendon actuators. The positioning error of the robot ranged from 10 microm to 359 microm, depending on measurement condition (e.g., loaded or unloaded, quasistatic or dynamic motion, centralized movements or extremes of travel, maximum value, or root-mean-square, and x-, y- or z-axis motion). Algorithms and methods for controlling

  15. Design, processing, and properties of Bi 2212\\/Ag Rutherford cables

    CERN Document Server

    Collings, E W; Scanlan, R M; Dietderich, D R; Motowidlo, L R; Sokolowski, R S; Aoki, Y; Hasegawa, T

    1999-01-01

    In a program intended to explore the use of high temperature superconducting (HTSC) cables in high field synchrotron dipole magnets model Bi:2212/Ag Rutherford cables were designed bearing in mind the needs for mechanical integrity, relatively high tensile strength, and low coupling losses. To satisfy these needs a core-type cable design was selected and a readily available heat-resistant core material acquired. Cables were wound for critical current- and AC loss measurement. Both winding-induced (mechanical) and core-induced (chemical) critical current degradation was examined. Interstrand coupling loss was measured calorimetrically on model cable samples with bare- and oxide-coated cores. From the results it was predicted that the losses of full-scale Bi:2212/Ag-wound LHC-type Rutherford cables would fall close to the acceptability range for the windings of high-field accelerator dipoles. (10 refs).

  16. Polymers designed for laser ablation-influence of photochemical properties

    International Nuclear Information System (INIS)

    Lippert, T.; Dickinson, J.T.; Hauer, M.; Kopitkovas, G.; Langford, S.C.; Masuhara, H.; Nuyken, O.; Robert, J.; Salmio, H.; Tada, T.; Tomita, K.; Wokaun, A.

    2002-01-01

    The ablation characteristics of various polymers were studied at low and high fluences. The polymers can be divided into three groups, i.e. polymers containing triazene and ester groups, the same polymers without the triazene group, and polyimide as reference polymer. At high fluences similar ablation parameters, i.e. etch rates and effective absorption coefficients, were obtained for all polymers. The main difference is the absence of carbon deposits for the designed polymers. At low fluences (at 308 nm) very pronounced differences are detected. The polymers containing the photochemically most active group (triazene) exhibit the lowest threshold of ablation (as low as 25 mJ cm -2 ) and the highest etch rates (up to 3 μm/pulse), followed by the designed polyesters and then polyimide. The laser-induced decomposition of the designed polymers was studied by nanosecond-interferometry. Only the triazene-polymer reveals etching without any sign of surface swelling, which is observed for all other polymers. The etching of the triazene-polymer starts and ends with the laser pulse, clearly indicating photochemical etching. The triazene-polymer was also studied by time-of-flight mass spectrometry (TOF-MS). The intensities of the ablation fragments show pronounced differences between irradiation at the absorption band of the triazene group (308 nm) and irradiation at a shorter wavelength (248 nm)

  17. Designer silica layers for advanced applications: Processing and properties

    Science.gov (United States)

    Anderson, Adam

    Recently, as scientists have investigated the application of conventional MEMS devices to biological systems, the exciting fields of bio-MEMS and microfluidics have emerged. Due to their small size, bio-MEMS and microfluidics devices offer the advantage of requiring only small sample and reagent volumes, in a potentially low-cost, integrated package. Such devices have the potential to significantly advance point-of-care diagnostics devices and improve overall patient care. However, due to the extremely small feature size, the large surface area-to-volume ratio in these devices makes controlling surface interactions of critical importance. Recently, there has been a shift to polymeric materials for fabrication of microfluidics devices due to their lower cost, ease of device fabrication by various processes, varied and favorable material properties, and, in some cases, pre-existing regulatory agency approvals. As a result, various surface modification strategies for polymeric surfaces have been proposed, but with only limited success. The proven success of organosilicon-based precursors in a wide variety of surface modification strategies has been demonstrated, with a body of knowledge on the general subject dating back nearly fifty years. However, these proven methodologies cannot be transferred to many important polymeric materials due to a lack of sufficient reactive groups on the surface. If any polymer surface could be made reactive by some intermediate treatment, the wide body of knowledge of organosilicon-based surface modification chemistries could be leveraged to advance the state-of-the-art in surface modification for microfluidics applications, where polymeric substrates are commonly encountered. This thesis reports on the processing properties and chemical properties of a vapor deposited silica layer, which is formed from the vapor phase hydrolysis of silicon tetrachloride. This layer can be deposited at low temperatures to a wide variety of substrates

  18. Preliminary Validation and Verification of TURBO{sub D}ESIGN for S-CO{sub 2} Axial Compressor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Je Kyoung; Lee, Jeong Ik; Ahn, Yoon Han; Kim, Seong Gu [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of); Yoon, Ho Joon; Addad, Yacine [Khalifa University of Science, Technology and Research, Abu Dhabi (United Arab Emirates)

    2012-05-15

    To use the advantages of Supercritical CO{sub 2}(S-CO{sub 2}) Brayton cycle for nuclear power plant, KAIST-Khalifa University joint research team has been focusing on S-CO{sub 2} turbomachinery development. TURBO{sub D}ESIGN code is one of the products of our researches to design a turbomachinery. The major feature of TURBO{sub D}ESIGN is that the formulation is based on the real gas and none of the ideal gas assumption was applied to the code. Thus, TURBO{sub D}ESIGN has high flexibility regarding the type of gases. In this paper, preliminary code validation and verification of TURBO{sub D}ESIGN will be discussed for axial type compressor design

  19. Design, Implementation and Validation of the Three-Wheel Holonomic Motion System of the Assistant Personal Robot (APR

    Directory of Open Access Journals (Sweden)

    Javier Moreno

    2016-10-01

    Full Text Available This paper presents the design, implementation and validation of the three-wheel holonomic motion system of a mobile robot designed to operate in homes. The holonomic motion system is described in terms of mechanical design and electronic control. The paper analyzes the kinematics of the motion system and validates the estimation of the trajectory comparing the displacement estimated with the internal odometry of the motors and the displacement estimated with a SLAM procedure based on LIDAR information. Results obtained in different experiments have shown a difference on less than 30 mm between the position estimated with the SLAM and odometry, and a difference in the angular orientation of the mobile robot lower than 5° in absolute displacements up to 1000 mm.

  20. Design, Implementation and Validation of the Three-Wheel Holonomic Motion System of the Assistant Personal Robot (APR).

    Science.gov (United States)

    Moreno, Javier; Clotet, Eduard; Lupiañez, Ruben; Tresanchez, Marcel; Martínez, Dani; Pallejà, Tomàs; Casanovas, Jordi; Palacín, Jordi

    2016-10-10

    This paper presents the design, implementation and validation of the three-wheel holonomic motion system of a mobile robot designed to operate in homes. The holonomic motion system is described in terms of mechanical design and electronic control. The paper analyzes the kinematics of the motion system and validates the estimation of the trajectory comparing the displacement estimated with the internal odometry of the motors and the displacement estimated with a SLAM procedure based on LIDAR information. Results obtained in different experiments have shown a difference on less than 30 mm between the position estimated with the SLAM and odometry, and a difference in the angular orientation of the mobile robot lower than 5° in absolute displacements up to 1000 mm.

  1. Design, Implementation and Validation of the Three-Wheel Holonomic Motion System of the Assistant Personal Robot (APR)

    Science.gov (United States)

    Moreno, Javier; Clotet, Eduard; Lupiañez, Ruben; Tresanchez, Marcel; Martínez, Dani; Pallejà, Tomàs; Casanovas, Jordi; Palacín, Jordi

    2016-01-01

    This paper presents the design, implementation and validation of the three-wheel holonomic motion system of a mobile robot designed to operate in homes. The holonomic motion system is described in terms of mechanical design and electronic control. The paper analyzes the kinematics of the motion system and validates the estimation of the trajectory comparing the displacement estimated with the internal odometry of the motors and the displacement estimated with a SLAM procedure based on LIDAR information. Results obtained in different experiments have shown a difference on less than 30 mm between the position estimated with the SLAM and odometry, and a difference in the angular orientation of the mobile robot lower than 5° in absolute displacements up to 1000 mm. PMID:27735857

  2. Human factors design, verification, and validation for two types of control room upgrades at a nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Boring, Laurids Ronald [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-10-01

    This paper describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of a new plant process computer (PPC) and turbine control system (TCS) at a representative nuclear power plant. This paper reviews ways to take a human-system interface (HSI) specification and use it when migrating legacy PPC displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then undergo an integrated system validation (ISV) in a full scope control room training simulator. Following the successful demonstration of operator performance with the systems during the ISV, the new system is implemented at the plant, first in the training simulator and then in the main control room.

  3. Human factors design, verification, and validation for two types of control room upgrades at a nuclear power plant

    International Nuclear Information System (INIS)

    Boring, Laurids Ronald

    2014-01-01

    This paper describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of a new plant process computer (PPC) and turbine control system (TCS) at a representative nuclear power plant. This paper reviews ways to take a human-system interface (HSI) specification and use it when migrating legacy PPC displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then undergo an integrated system validation (ISV) in a full scope control room training simulator. Following the successful demonstration of operator performance with the systems during the ISV, the new system is implemented at the plant, first in the training simulator and then in the main control room.

  4. Designing and determining validity and reliability of a questionnaire to identify factors affecting nutritional behavior among patients with metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Naseh Esmaeili

    2017-06-01

    Full Text Available Background : A number of studies have shown a clear relationship between diet and component of metabolic syndrome. Based on the Theory of Reasoned Action (TRA, attitude and subjective norm are factors affecting behavioral intention and subsequently behavior. The aim of the present study is to design a valid questionnaire identifying factors affecting nutritional behavior among patients with metabolic syndrome. Materials and Methods: Via literature review, six focus group discussion and interview with nutrition specialists were performed to develop an instrument based on the theory of reasoned action. To determine validity of the instrument, content and face validity analyses with 15 expert panels conducted and also to determine reliability, Cronbach’s Alpha coefficient performed. Results: A draft of 100 items questionnaire was developed and after evaluation of validity and reliability, final questionnaire included 46 items: 17 items for attitude, 13 items for subjective norms and 16 items for behavioral intention. For the final questionnaire average of content validity index was 0/92 and Cronbach’s Alpha coefficient was 0/85. Conclusion: Based on the results of the current study the developed questionnaire is a valid and reliable instrument and it can be used to identify factors affecting nutritional behavior among people with metabolic syndrome based on the theory of reasoned action.

  5. The psychometric properties of the PABS-PT in neck pain patients: a validation study.

    NARCIS (Netherlands)

    Mutsaers, J.H.; Pool-Goudzwaard, A.L.; Ostelo, R.W.J.G.; Peters, R.; Koes, B.W.; Verhagen, A.

    2014-01-01

    Objective: This study aims to assess the reliability and validity of the Pain Attitudes and Beliefs Scale for Physiotherapists (PABS-PT) in neck pain patients. Three research goals were formulated. (1): to reexamine the factor structure of the PABS-PT, (2) to assess the test-retest reliability of

  6. Engineering properties of stabilized subgrade soils for implementation of the AASHTO 2002 pavement design guide.

    Science.gov (United States)

    2009-06-01

    A comprehensive laboratory study was undertaken to determine engineering properties of cementitiously stabilized common subgrade soils in Oklahoma for the design of roadway pavements in accordance with the AASHTO 2002 Mechanistic-Empirical Pavement D...

  7. Validation and psychometric properties of the Alcohol Positive and Negative Affect Schedule: Are drinking emotions distinct from general emotions?

    Science.gov (United States)

    Lac, Andrew; Donaldson, Candice D

    2018-02-01

    People vary in experiences of positive and negative emotions from consuming alcohol, but no validated measurement instrument exclusively devoted to assessing drinking emotions exists in the literature. The current research validated and evaluated the psychometric properties of an alcohol affect scale based on adjectives from the Positive and Negative Affect Schedule (PANAS) and tested the extent that emotions incurred from drinking were distinct from general trait-based emotions. Three studies tested independent samples of adult alcohol users. In Study 1 (N = 494), exploratory factor analyses of the Alcohol PANAS revealed that both the 20-item model and the 9-parcel model (represented by similar mood content) supported the 2-factor dimensionality of alcohol positive and negative affect. In Study 2 (N = 302), confirmatory factor analyses corroborated the measurement structure of alcohol positive and negative affect, and both constructs evidenced statistical independence from general positive and negative affect. In Study 3 (N = 452), alcohol positive and negative affect exhibited discriminant, convergent, and criterion validity with established alcohol scales. Incremental validity tests demonstrated that alcohol positive and negative affect uniquely contributed (beyond general positive and negative affect) to alcohol expectancies, use, and problems. Findings support that alcohol emotions are conceptually distinct from trait emotions, and underscore the necessity of an assessment instrument tailored to the former to examine associations with alcohol beliefs and behaviors. The Alcohol PANAS confers theoretical and practical applications to understand the emotional consequences of drinking. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  8. Properties of idealized designs of NB3SN composites

    International Nuclear Information System (INIS)

    Smathers, D.B.; Larbalestier, D.C.; Lee, P.J.; Marken, K.R.; McDonald, W.K.; O'Larey, P.M.

    1985-01-01

    A series of seven idealized bronze-Nb 3 Sn composites were manufactured by the MJR process with varying matrix to filament ratios and pure Nb and Nb 0.8 wt.% Ti cores. The central core of each composite was sealed by a diffusion barrier which results in each filament having an identical source of tin. Initial evaluations of the composites from critical current and transmission electron microscopy measurements are presented and their properties compared to standard MJR composites. The Nb 3 Sn current density does not appear to be a strong function of bronze to Nb ratio over the range 2.4 to 3.2:1. The standard MJR composites have higher critical current densities than the idealized composites. It is proposed that the major reason for the increased current density of the normal MJR conductors is the intrinsically higher quality of the filaments close to the central tin core. It is postulated that the high Sn content of the bronze surrounding these filaments leads to an intrinsically higher Nb 3 Sn filament current density

  9. Design of optical fibres with advanced modal control properties

    DEFF Research Database (Denmark)

    Muliar, Olena

    this goal, an interferometric-based fibre characterisation technique, known as a cross-correlated (C 2 ) imaging, was explored. An alternative modal reconstruction approach by 2D Fourier transform was presented, that allowed to extract intensity and phase distributions of the fibre mode from a single...... interferogram, acquired by a camera at a specific time delay. Aforementioned reconstruction technique was implemented for a flexible C 2 imaging, which was realised by an application of a tunable and highly flexible light source. Current configuration of the C 2 set-up gave an opportunity to investigate...... an influence of a spectral shape and bandwidth on a temporal resolution of the method and to form the input spectrum according to experimental requirements of the fibre design. A demonstration of the flexible C 2 imaging was performed by a characterisation of a step-index fibre (SMF28) and a distributed mode...

  10. Riveted Lap Joints in Aircraft Fuselage Design, Analysis and Properties

    CERN Document Server

    Skorupa, Andrzej

    2012-01-01

    Fatigue of the pressurized fuselages of transport aircraft is a significant problem all builders and users of aircraft have to cope with for reasons associated with assuring a sufficient lifetime and safety, and formulating adequate inspection procedures. These aspects are all addressed in various formal protocols for creating and maintaining airworthiness, including damage tolerance considerations. In most transport aircraft, fatigue occurs in lap joints, sometimes leading to circumstances that threaten safety in critical ways. The problem of fatigue of lap joints has been considerably enlarged by the goal of extending aircraft lifetimes. Fatigue of riveted lap joints between aluminium alloy sheets, typical of the pressurized aircraft fuselage, is the major topic of the present book. The richly illustrated and well-structured chapters treat subjects such as: structural design solutions and loading conditions for fuselage skin joints; relevance of laboratory test results for simple lap joint specimens to rive...

  11. Lipid technology: Property prediction and process design/analysis in the edible oil and biodiesel industries

    DEFF Research Database (Denmark)

    Díaz Tovar, Carlos Axel; Gani, Rafiqul; Sarup, Bent

    2011-01-01

    acid methyl esters); their representation and classification in terms of molecular structures; the collection of available experimental data of their pure component physical properties; the adoption of appropriate property-process models for the design and analysis of production processes through......In this work some of the property related issues in lipid processing technology employed in edible oil and biodiesel production are highlighted. This includes the identification of the most representative chemical species (acylglycerides, free fatty acids, tocopherols, sterols, carotenes, and fatty...

  12. Design Research and the Solo Higher Degree Research Student: Strategies to Embed Trustworthiness and Validity into the Research Design

    Science.gov (United States)

    Kennedy-Clark, Shannon

    2012-01-01

    This paper puts forward a set of criteria for ensuring trustworthiness in design research studies undertaken by Higher Degree Research (HDR) students. Design research is aimed at exploring educational problems and refining theory and practice by defining a pedagogical outcome and is a methodological approach often associated with the Learning…

  13. The Work Design Questionnaire (WDQ): Developing and Validating a Comprehensive Measure for Assessing Job Design and the Nature of Work

    Science.gov (United States)

    Morgeson, Frederick P.; Humphrey, Stephen E.

    2006-01-01

    Although there are thousands of studies investigating work and job design, existing measures are incomplete. In an effort to address this gap, the authors reviewed the work design literature, identified and integrated previously described work characteristics, and developed a measure to tap those work characteristics. The resultant Work Design…

  14. Psychometric Properties and Structural Validity of the Short Version of the Personality Beliefs Questionnaire (PBQ-SF

    Directory of Open Access Journals (Sweden)

    Rubén Darío Manrique Hernández

    2016-06-01

    Full Text Available The Personality Belief Questionnaire- Short Form (PBQ-SF is an assessment instrument of personality beliefs based on the cognitive theory that states that these are characterized by a specific pattern of dysfunctional thoughts. The objective of this study was to establish the psychometric properties and structural validity of the PBQ-SF questionnaire in Colombian adults from 18 to 35 years old. To carry out the above and with permission of the author the validation process was initiated following a thorough and rigorous process that led to a final version of the PBQ-SF applied to 1423 persons born in Colombia and living in nine Colombian cities. Analysis of internal consistency among the items (Cronbach´s alpha, confirmatory factor analysis and calculus of goodness of fit estimators were performed. It was found that the Internal consistency of the domains varied from 0,65 for avoidant disorder up to 0,83 for paranoid disorder.

  15. The water balance questionnaire: design, reliability and validity of a questionnaire to evaluate water balance in the general population.

    Science.gov (United States)

    Malisova, Olga; Bountziouka, Vassiliki; Panagiotakos, Demosthenes B; Zampelas, Antonis; Kapsokefalou, Maria

    2012-03-01

    There is a need to develop a questionnaire as a research tool for the evaluation of water balance in the general population. The water balance questionnaire (WBQ) was designed to evaluate water intake from fluid and solid foods and drinking water, and water loss from urine, faeces and sweat at sedentary conditions and physical activity. For validation purposes, the WBQ was administrated in 40 apparently healthy participants aged 22-57 years (37.5% males). Hydration indices in urine (24 h volume, osmolality, specific gravity, pH, colour) were measured through established procedures. Furthermore, the questionnaire was administered twice to 175 subjects to evaluate its reliability. Kendall's τ-b and the Bland and Altman method were used to assess the questionnaire's validity and reliability. The proposed WBQ to assess water balance in healthy individuals was found to be valid and reliable, and it could thus be a useful tool in future projects that aim to evaluate water balance.

  16. Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom.

    Science.gov (United States)

    Knight, Stacey; Camp, Nicola J

    2011-04-01

    Current common wisdom posits that association analyses using family-based designs have inflated type 1 error rates (if relationships are ignored) and independent controls are more powerful than familial controls. We explore these suppositions. We show theoretically that family-based designs can have deflated type-error rates. Through simulation, we examine the validity and power of family designs for several scenarios: cases from randomly or selectively ascertained pedigrees; and familial or independent controls. Family structures considered are as follows: sibships, nuclear families, moderate-sized and extended pedigrees. Three methods were considered with the χ(2) test for trend: variance correction (VC), weighted (weights assigned to account for genetic similarity), and naïve (ignoring relatedness) as well as the Modified Quasi-likelihood Score (MQLS) test. Selectively ascertained pedigrees had similar levels of disease enrichment; random ascertainment had no such restriction. Data for 1,000 cases and 1,000 controls were created under the null and alternate models. The VC and MQLS methods were always valid. The naïve method was anti-conservative if independent controls were used and valid or conservative in designs with familial controls. The weighted association method was generally valid for independent controls, and was conservative for familial controls. With regard to power, independent controls were more powerful for small-to-moderate selectively ascertained pedigrees, but familial and independent controls were equivalent in the extended pedigrees and familial controls were consistently more powerful for all randomly ascertained pedigrees. These results suggest a more complex situation than previously assumed, which has important implications for study design and analysis. © 2011 Wiley-Liss, Inc.

  17. Validation of Product Properties Considering a High Variety of Complex Products

    OpenAIRE

    Kortler, S.;Kohn, A.;Lindemann, U.

    2017-01-01

    Validation processes are becoming more and more complex. Due to rising technical capabilities and a wide variety of customer requirements, OEMs are increasing their product variety in order to increase profits. According to the various characteristics of subcontracted components involved in complex products, the product variety can be very high. The impacts of the involved subcontracted components on the composed product variety during the product’s application are difficult to predict. This ...

  18. Further Validation of the Coach Identity Prominence Scale

    Science.gov (United States)

    Pope, J. Paige; Hall, Craig R.

    2014-01-01

    This study was designed to examine select psychometric properties of the Coach Identity Prominence Scale (CIPS), including the reliability, factorial validity, convergent validity, discriminant validity, and predictive validity. Coaches (N = 338) who averaged 37 (SD = 12.27) years of age, had a mean of 13 (SD = 9.90) years of coaching experience,…

  19. A symptom self-rating scale for schizophrenia (4S): psychometric properties, reliability and validity.

    Science.gov (United States)

    Lindström, Eva; Jedenius, Erik; Levander, Sten

    2009-01-01

    The objective of the study was to validate a self-administrated symptom rating scale for use in patients with schizophrenia spectrum disorders by item analysis, exploration of factor structure, and analyses of reliability and validity. Data on 151 patients, initially treated by risperidone, obtained within the framework of a naturalistic Phase IV longitudinal study, were analysed by comparing patient and clinician ratings of symptoms, side-effects and global indices of illness. The Symptom Self-rating Scale for Schizophrenia (4S) is psychometrically adequate (item analysis, internal consistency, factor structure). Side-effect ratings were reliable. Symptom ratings displayed consistent associations with clinicians' ratings of corresponding symptom dimensions, suggesting construct validity. Patients had most difficulties assessing negative symptom items. Patients were well able to assess their own symptoms and drug side-effects. The factor structure of symptom ratings differs between patients and clinicians as well as how they construe global indices of illness. Clinicians focus on psychotic, patients on affective symptoms. Use of symptom self-ratings is one way to improve communication and thereby strengthen the therapeutic alliance and increase treatment adherence.

  20. Validation of Serious Games

    Directory of Open Access Journals (Sweden)

    Katinka van der Kooij

    2015-09-01

    Full Text Available The application of games for behavioral change has seen a surge in popularity but evidence on the efficacy of these games is contradictory. Anecdotal findings seem to confirm their motivational value whereas most quantitative findings from randomized controlled trials (RCT are negative or difficult to interpret. One cause for the contradictory evidence could be that the standard RCT validation methods are not sensitive to serious games’ effects. To be able to adapt validation methods to the properties of serious games we need a framework that can connect properties of serious game design to the factors that influence the quality of quantitative research outcomes. The Persuasive Game Design model [1] is particularly suitable for this aim as it encompasses the full circle from game design to behavioral change effects on the user. We therefore use this model to connect game design features, such as the gamification method and the intended transfer effect, to factors that determine the conclusion validity of an RCT. In this paper we will apply this model to develop guidelines for setting up validation methods for serious games. This way, we offer game designers and researchers handles on how to develop tailor-made validation methods.

  1. Design and Establishment of Database on the AtoN Properties for AtoN Simulator

    Directory of Open Access Journals (Sweden)

    Ji-Min Yeo

    2015-12-01

    Full Text Available This study investigated the design and establishment of AtoN(Aids to Navigation in the AtoN Simulator. In recent years, IALA(International Association of Lighthouse Authorities has raised the need of a system which could verify whether AtoN is appropriate for the design of AtoN and placement planning. An AtoN Simulator provides simulation circumstances, including the topographical and environmental characteristics of a primary harbor and the characteristics of a navigating ship and the maritime traffic. In the present study, we have developed an AtoN simulator system, including the integrated system design and the construction of an AtoN database. The AtoN Manager was developed as a virtual AtoN to manage the AtoN simulation. However, the data and materials are difficult to manage. Hence, an AtoN Manager and an AtoN simulation system have been needed for an effective managing of the AtoN properties database data. For the database structure design, we have analyzed the database design methodology. The AtoN properties have been analyzed for the effective data management. The AtoN properties designed in the present paper were classified into 19 categories. The status and properties database of AtoN were installed in 14 major ports, those were applied to the AtoN Manager. Designing the AtoN properties database was defined to reduce confusion of the use of English terms and abbreviations. The terms and acronyms have been defined in the AtoN properties and designed to the properties database structure for each AtoN. Before structuring the database for the AtoN Manager, the data of the AtoN properties for each harbor have been organized in accordance with the Excel system. The regulated data were converted into the AtoN properties database in use for the AtoN Manager. The database based on the AtoN properties table structure to each AtoN was designed. The AtoN simulator was implemented by the AtoN Manager applied to the AtoN properties database.

  2. Application of a computational situation assessment model to human system interface design and experimental validation of its effectiveness

    International Nuclear Information System (INIS)

    Lee, Hyun-Chul; Koh, Kwang-Yong; Seong, Poong-Hyun

    2013-01-01

    Highlights: ► We validate the effectiveness of a proposed procedure thru an experiment. ► The proposed procedure addresses the salient coding of the key information. ► It was found that salience coding affects operators’ attention significantly. ► The first observation to the key information quickly guided to the correct situation awareness. ► It was validated the proposed procedure is effective for better situation awareness. - Abstract: To evaluate the effects of human cognitive characteristics on situation awareness, a computational situation assessment model of nuclear power plant operators has been developed, as well as a procedure to apply the developed model to the design of human system interfaces (HSIs). The concept of the proposed procedure is to identify the key information source, which is expected to guarantee fast and accurate diagnosis when operators attend to it. The developed computational model is used to search the diagnostic paths and the key information source. In this study, an experiment with twelve trained participants was executed to validate the effectiveness of the proposed procedure. Eighteen scenarios covering various accidents were administered twice for each subject, and experimental data were collected and analyzed. As a result of the data analysis, it was validated that the salience level of information sources significantly influences the attention of operators, and the first observation of the key information sources leads operators to a quick and correct situation assessment. Therefore, we conclude that the proposed procedure for applying the developed model to HSI design is effective

  3. Towards practical application of sensors for monitoring animal health; design and validation of a model to detect ketosis.

    Science.gov (United States)

    Steensels, Machteld; Maltz, Ephraim; Bahr, Claudia; Berckmans, Daniel; Antler, Aharon; Halachmi, Ilan

    2017-05-01

    The objective of this study was to design and validate a mathematical model to detect post-calving ketosis. The validation was conducted in four commercial dairy farms in Israel, on a total of 706 multiparous Holstein dairy cows: 203 cows clinically diagnosed with ketosis and 503 healthy cows. A logistic binary regression model was developed, where the dependent variable is categorical (healthy/diseased) and a set of explanatory variables were measured with existing commercial sensors: rumination duration, activity and milk yield of each individual cow. In a first validation step (within-farm), the model was calibrated on the database of each farm separately. Two thirds of the sick cows and an equal number of healthy cows were randomly selected for model validation. The remaining one third of the cows, which did not participate in the model validation, were used for model calibration. In order to overcome the random selection effect, this procedure was repeated 100 times. In a second (between-farms) validation step, the model was calibrated on one farm and validated on another farm. Within-farm accuracy, ranging from 74 to 79%, was higher than between-farm accuracy, ranging from 49 to 72%, in all farms. The within-farm sensitivities ranged from 78 to 90%, and specificities ranged from 71 to 74%. The between-farms sensitivities ranged from 65 to 95%. The developed model can be improved in future research, by employing other variables that can be added; or by exploring other models to achieve greater sensitivity and specificity.

  4. Experimental Validation of the Dynamic Inertia Measurement Method to Find the Mass Properties of an Iron Bird Test Article

    Science.gov (United States)

    Chin, Alexander W.; Herrera, Claudia Y.; Spivey, Natalie D.; Fladung, William A.; Cloutier, David

    2015-01-01

    The mass properties of an aerospace vehicle are required by multiple disciplines in the analysis and prediction of flight behavior. Pendulum oscillation methods have been developed and employed for almost a century as a means to measure mass properties. However, these oscillation methods are costly, time consuming, and risky. The NASA Armstrong Flight Research Center has been investigating the Dynamic Inertia Measurement, or DIM method as a possible alternative to oscillation methods. The DIM method uses ground test techniques that are already applied to aerospace vehicles when conducting modal surveys. Ground vibration tests would require minimal additional instrumentation and time to apply the DIM method. The DIM method has been validated on smaller test articles, but has not yet been fully proven on large aerospace vehicles.

  5. Design and validation of the INICIARE instrument, for the assessment of dependency level in acutely ill hospitalised patients.

    Science.gov (United States)

    Morales-Asencio, José Miguel; Porcel-Gálvez, Ana María; Oliveros-Valenzuela, Rosa; Rodríguez-Gómez, Susana; Sánchez-Extremera, Lucrecia; Serrano-López, Francisco Andrés; Aranda-Gallardo, Marta; Canca-Sánchez, José Carlos; Barrientos-Trigo, Sergio

    2015-03-01

    The aim of this study was to establish the validity and reliability of an instrument (Inventario del NIvel de Cuidados mediante IndicAdores de clasificación de Resultados de Enfermería) used to assess the dependency level in acutely hospitalised patients. This instrument is novel, and it is based on the Nursing Outcomes Classification. Multiple existing instruments for needs assessment have been poorly validated and based predominately on interventions. Standardised Nursing Languages offer an ideal framework to develop nursing sensitive instruments. A cross-sectional validation study in two acute care hospitals in Spain. This study was implemented in two phases. First, the research team developed the instrument to be validated. In the second phase, the validation process was performed by experts, and the data analysis was conducted to establish the psychometric properties of the instrument. Seven hundred and sixty-one patient ratings performed by nurses were collected during the course of the research study. Data analysis yielded a Cronbach's alpha of 0·91. An exploratory factorial analysis identified three factors (Physiological, Instrumental and Cognitive-behavioural), which explained 74% of the variance. Inventario del NIvel de Cuidados mediante IndicAdores de clasificación de Resultados de Enfermería was demonstrated to be a valid and reliable instrument based on its use in acutely hospitalised patients to assess the level of dependency. Inventario del NIvel de Cuidados mediante IndicAdores de clasificación de Resultados de Enfermería can be used as an assessment tool in hospitalised patients during the nursing process throughout the entire hospitalisation period. It contributes information to support decisions on nursing diagnoses, interventions and outcomes. It also enables data codification in large databases. © 2014 John Wiley & Sons Ltd.

  6. Design and validation of a three-instrument toolkit for the assessment of competence in electrocardiogram rhythm recognition.

    Science.gov (United States)

    Hernández-Padilla, José M; Granero-Molina, José; Márquez-Hernández, Verónica V; Suthers, Fiona; López-Entrambasaguas, Olga M; Fernández-Sola, Cayetano

    2017-06-01

    Rapid and accurate interpretation of cardiac arrhythmias by nurses has been linked with safe practice and positive patient outcomes. Although training in electrocardiogram rhythm recognition is part of most undergraduate nursing programmes, research continues to suggest that nurses and nursing students lack competence in recognising cardiac rhythms. In order to promote patient safety, nursing educators must develop valid and reliable assessment tools that allow the rigorous assessment of this competence before nursing students are allowed to practise without supervision. The aim of this study was to develop and psychometrically evaluate a toolkit to holistically assess competence in electrocardiogram rhythm recognition. Following a convenience sampling technique, 293 nursing students from a nursing faculty in a Spanish university were recruited for the study. The following three instruments were developed and psychometrically tested: an electrocardiogram knowledge assessment tool (ECG-KAT), an electrocardiogram skills assessment tool (ECG-SAT) and an electrocardiogram self-efficacy assessment tool (ECG-SES). Reliability and validity (content, criterion and construct) of these tools were meticulously examined. A high Cronbach's alpha coefficient demonstrated the excellent reliability of the instruments (ECG-KAT=0.89; ECG-SAT=0.93; ECG-SES=0.98). An excellent context validity index (scales' average content validity index>0.94) and very good criterion validity were evidenced for all the tools. Regarding construct validity, principal component analysis revealed that all items comprising the instruments contributed to measure knowledge, skills or self-efficacy in electrocardiogram rhythm recognition. Moreover, known-groups analysis showed the tools' ability to detect expected differences in competence between groups with different training experiences. The three-instrument toolkit developed showed excellent psychometric properties for measuring competence in

  7. Content Validity and Psychometric Properties of the Nomination Scale for Identifying Football Talent (NSIFT: Application to Coaches, Parents and Players

    Directory of Open Access Journals (Sweden)

    Alejandro Prieto-Ayuso

    2017-01-01

    Full Text Available The identification of football talent is a critical issue both for clubs and the families of players. However, despite its importance in a sporting, economic and social sense, there appears to be a lack of instruments that can reliably measure talent performance. The aim of this study was to design and validate the Nomination Scale for Identifying Football Talent (NSIFT, with the aim of optimising the processes for identifying said talent. The scale was first validated through expert judgment, and then statistically, by means of an exploratory factor analysis (EFA, confirmatory factor analysis (CFA, internal reliability and convergent validity. The results reveal the presence of three factors in the scale’s factor matrix, with these results being confirmed by the CFA. The scale revealed suitable internal reliability and homogeneity indices. Convergent validity showed that it is teammates who are best able to identify football talent, followed by coaches and parents. It can be concluded that the NSIFT is suitable for use in the football world. Future studies should seek to confirm these results in different contexts by means of further CFAs.

  8. 14 CFR 29.613 - Material strength properties and design values.

    Science.gov (United States)

    2010-01-01

    ... Administrator: (1) MIL—HDBK-5, “Metallic Materials and Elements for Flight Vehicle Structure”. (2) MIL—HDBK-17, “Plastics for Flight Vehicles”. (3) ANC-18, “Design of Wood Aircraft Structures”. (4) MIL—HDBK-23... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Material strength properties and design...

  9. 14 CFR 27.613 - Material strength properties and design values.

    Science.gov (United States)

    2010-01-01

    ... Administrator: (1) MIL-HDBK-5, “Metallic Materials and Elements for Flight Vehicle Structure”. (2) MIL-HDBK-17, “Plastics for Flight Vehicles”. (3) ANC-18, “Design of Wood Aircraft Structures”. (4) MIL-HDBK-23... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Material strength properties and design...

  10. Cluster designs to assess the prevalence of acute malnutrition by lot quality assurance sampling: a validation study by computer simulation.

    Science.gov (United States)

    Olives, Casey; Pagano, Marcello; Deitchler, Megan; Hedt, Bethany L; Egge, Kari; Valadez, Joseph J

    2009-04-01

    Traditional lot quality assurance sampling (LQAS) methods require simple random sampling to guarantee valid results. However, cluster sampling has been proposed to reduce the number of random starting points. This study uses simulations to examine the classification error of two such designs, a 67x3 (67 clusters of three observations) and a 33x6 (33 clusters of six observations) sampling scheme to assess the prevalence of global acute malnutrition (GAM). Further, we explore the use of a 67x3 sequential sampling scheme for LQAS classification of GAM prevalence. Results indicate that, for independent clusters with moderate intracluster correlation for the GAM outcome, the three sampling designs maintain approximate validity for LQAS analysis. Sequential sampling can substantially reduce the average sample size that is required for data collection. The presence of intercluster correlation can impact dramatically the classification error that is associated with LQAS analysis.

  11. Validity of a Checklist for the Design, Content, and Instructional Qualities of Children's Books

    Science.gov (United States)

    Çer, Erkan; Sahin, Ertugrul

    2016-01-01

    The purpose of this study was to develop a checklist whose validity has been tested in assessing children's books. Participants consisted of university students who had taken a course in children's literature. They were selected through convenience sampling and randomly assigned into experimental and control groups. Participants in the…

  12. The GOFC-GOLD/CEOS Land Cover Harmonization and Validation Initiative: Technical Design and Implementation

    Science.gov (United States)

    Herold, M.; Woodcock, C.; Stehman, S.; Nightingale, J.; Friedl, M.; Schmullius, C.

    2010-12-01

    A global effort to assess the accuracy of existing and future land cover products derived from a variety of satellite sensors over a range of spatial resolutions is being led by the Land Cover Implementation Team (LC-IT) of GOFC/GOLD (Global Observation of Land Cover Dynamics) in conjunction with the CEOS (Committee on Earth Observation Satellites) WGCV (Working Group on Calibration and Validation) LPV (Land Product Validation) subgroup. The first phase of this effort is complete and culminated in a publication of community consensus "best practices" for validation of global land cover datasets (2). The next phase is to implement the recommendations outlined in the "best practices" document. A "living database" of global randomized sample sites will form the basis of accuracy assessment for a host of global land cover products (GLC2000, MODIS land cover, GLOBCOVER, United Nation's Forest Resource Assessment (FRA2010), and the Mid-Decadal Global Land Survey. This "living dataset" will also be a community resource available for use in validation of regional or national mapping efforts using LCCS (UN FAO's Land Cover Classification System). Based on the known accuracy of existing land cover products, GOFC/GOLD will to develop and update a "best currently available" global land cover map. Individual geographic regions may be selected from different land cover products (global, national or regional), or they may be combined in various ways

  13. The reward probability index: design and validation of a scale measuring access to environmental reward.

    Science.gov (United States)

    Carvalho, John P; Gawrysiak, Michael J; Hellmuth, Julianne C; McNulty, James K; Magidson, Jessica F; Lejuez, C W; Hopko, Derek R

    2011-06-01

    Behavioral models of depression implicate decreased response-contingent positive reinforcement (RCPR) as critical toward the development and maintenance of depression (Lewinsohn, 1974). Given the absence of a psychometrically sound self-report measure of RCPR, the Reward Probability Index (RPI) was developed to measure access to environmental reward and to approximate actual RCPR. In Study 1 (n=269), exploratory factor analysis supported a 20-item two-factor model (Reward Probability, Environmental Suppressors) with strong internal consistency (α=.90). In Study 2 (n=281), confirmatory factor analysis supported this two-factor structure and convergent validity was established through strong correlations between the RPI and measures of activity, avoidance, reinforcement, and depression (r=.65 to .81). Discriminant validity was supported via smaller correlations between the RPI and measures of social support and somatic anxiety (r=-.29 to -.40). Two-week test-retest reliability was strong (r=.69). In Study 3 (n=33), controlling for depression symptoms, hierarchical regression supported the incremental validity of the RPI in predicting daily diary reports of environmental reward. The RPI represents a parsimonious, reliable, and valid measure that may facilitate understanding of the etiology of depression and its relationship to overt behaviors. Copyright © 2011. Published by Elsevier Ltd.

  14. Validation of a functional model for integration of safety into process system design

    DEFF Research Database (Denmark)

    Wu, J.; Lind, M.; Zhang, X.

    2015-01-01

    with the process system functionalities as required for the intended safety applications. To provide the scientific rigor and facilitate the acceptance of qualitative modelling, this contribution focuses on developing a scientifically based validation method for functional models. The Multilevel Flow Modeling (MFM...

  15. Design and Validation of a Straight-Copy Typewriting Prognostic Test Using Kinesthetic Sensitivity.

    Science.gov (United States)

    Olson, Norma Jean

    1979-01-01

    Describes the development and application of a kinesthetic sensitivity test to determine whether it is a valid and reliable measure of straight-copy typing speed and accuracy. The author states that this kinesthetic sensitivity instrument may be used as a prognostic aptitude test and recommends administration methods. (MF)

  16. An extended protocol for usability validation of medical devices : Research design and reference model

    NARCIS (Netherlands)

    Schmettow, M.; Schnittker, R.; Schraagen, J.M.

    2017-01-01

    This paper proposes and demonstrates an extended protocol for usability validation testing of medical devices. A review of currently used methods for the usability evaluation of medical devices revealed two main shortcomings. Firstly, the lack of methods to closely trace the interaction sequences

  17. Thermodynamic properties of 9-fluorenone: Mutual validation of experimental and computational results

    International Nuclear Information System (INIS)

    Chirico, Robert D.; Kazakov, Andrei F.; Steele, William V.

    2012-01-01

    Highlights: ► Heat capacities were measured for the temperature range 5 K to 520 K. ► Vapor pressures were measured for the temperature range 368 K to 668 K. ► The enthalpy of combustion was measured and the enthalpy of formation was derived. ► Calculated and derived properties for the ideal gas are in excellent accord. ► Thermodynamic consistency analysis revealed anomalous literature data. - Abstract: Measurements leading to the calculation of thermodynamic properties for 9-fluorenone (IUPAC name 9H-fluoren-9-one and Chemical Abstracts registry number [486-25-9]) in the ideal-gas state are reported. Experimental methods were adiabatic heat-capacity calorimetry, inclined-piston manometry, comparative ebulliometry, and combustion calorimetry. Critical properties were estimated. Molar entropies for the ideal-gas state were derived from the experimental studies at selected temperatures T between T = 298.15 K and T = 600 K, and independent statistical calculations were performed based on molecular geometry optimization and vibrational frequencies calculated at the B3LYP/6 − 31 + G(d,p) level of theory. Values derived with the independent methods are shown to be in excellent accord with a scaling factor of 0.975 applied to the calculated frequencies. This same scaling factor was successfully applied in the analysis of results for other polycyclic molecules, as described in recent articles by this research group. All experimental results are compared with property values reported in the literature. Thermodynamic consistency between properties is used to show that several studies in the literature are erroneous.

  18. ITER - Progress in design and validating R and D. Note by the Director. ITER meeting, Moscow, 28 June 2000

    International Nuclear Information System (INIS)

    2001-01-01

    This note summarises, for the ITER Council, material presented in detail to TAC, in the report ''Progress in Resolving Open Design Issues from the ODR'', including: further investigation of physics issues raised in the TAC report or in the course of the Parties' domestic assessments; and features of the ITER design which reflect a resolution of choice of options. In addition, the note summarises and illustrates recent progress in the programme of validating technology R and D, as presented in the report to TAC, ''ITER Technology R and D Progress Report''

  19. Development of a Human Performance Evaluation Support System for Human Factors Validation of MCR MMI Design in APR-1400

    International Nuclear Information System (INIS)

    Ha, Jun Su; Seong, Poong Hyun

    2005-01-01

    As CRT-based display and advanced information technology were applied to advanced reactors such as APR-1400 (Advanced Power Reactor-1400), human operators' tasks became more cognitive works. As a results, Human Factors Engineering (HFE) became more important in designing the MCR (Main Control Room) MMI (Man-Machine Interface) of an advanced reactor. According to the Human Factors Engineering Program Review Model, human factors validation of MCR MMI design should be performed through performance-based tests to determine whether it acceptably supports safe operation of the plant. In order to support the evaluation of the performance, a HUman Performance Evaluation Support System (HUPESS) is in development

  20. Computer-aided polymer design using group contribution plus property models

    DEFF Research Database (Denmark)

    Satyanarayana, Kavitha Chelakara; Abildskov, Jens; Gani, Rafiqul

    2009-01-01

    . Polymer repeat unit property prediction models are required to calculate the properties of the generated repeat units. A systematic framework incorporating recently developed group contribution plus (GC(+)) models and an extended CAMD technique to include design of polymer repeat units is highlighted...... in this paper. The advantage of a GC(+) model in CAMD applications is that a very large number of polymer structures can be considered even though some of the group parameters may not be available. A number of case studies involving different polymer design problems have been solved through the developed......The preliminary step for polymer product design is to identify the basic repeat unit structure of the polymer that matches the target properties. Computer-aided molecular design (CAMD) approaches can be applied for generating the polymer repeat unit structures that match the required constraints...

  1. Development of Property Models with Uncertainty Estimate for Process Design under Uncertainty

    DEFF Research Database (Denmark)

    Hukkerikar, Amol; Sarup, Bent; Abildskov, Jens

    more reliable predictions with a new and improved set of model parameters for GC (group contribution) based and CI (atom connectivity index) based models and to quantify the uncertainties in the estimated property values from a process design point-of-view. This includes: (i) parameter estimation using....... The comparison of model prediction uncertainties with reported range of measurement uncertainties is presented for the properties with related available data. The application of the developed methodology to quantify the effect of these uncertainties on the design of different unit operations (distillation column......, the developed methodology can be used to quantify the sensitivity of process design to uncertainties in property estimates; obtain rationally the risk/safety factors in process design; and identify additional experimentation needs in order to reduce most critical uncertainties....

  2. Design and validation of an open-source library of dynamic reference frames for research and education in optical tracking.

    Science.gov (United States)

    Brown, Alisa; Uneri, Ali; Silva, Tharindu De; Manbachi, Amir; Siewerdsen, Jeffrey H

    2018-04-01

    Dynamic reference frames (DRFs) are a common component of modern surgical tracking systems; however, the limited number of commercially available DRFs poses a constraint in developing systems, especially for research and education. This work presents the design and validation of a large, open-source library of DRFs compatible with passive, single-face tracking systems, such as Polaris stereoscopic infrared trackers (NDI, Waterloo, Ontario). An algorithm was developed to create new DRF designs consistent with intra- and intertool design constraints and convert to computer-aided design (CAD) files suitable for three-dimensional printing. A library of 10 such groups, each with 6 to 10 DRFs, was produced and tracking performance was validated in comparison to a standard commercially available reference, including pivot calibration, fiducial registration error (FRE), and target registration error (TRE). Pivot tests showed calibration error [Formula: see text], indistinguishable from the reference. FRE was [Formula: see text], and TRE in a CT head phantom was [Formula: see text], both equivalent to the reference. The library of DRFs offers a useful resource for surgical navigation research and could be extended to other tracking systems and alternative design constraints.

  3. A formal design verification and validation on the human factors of a computerized information system in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Park, Jae Chang; Cheon, Se Woo; Jung, Kwang Tae; Baek, Seung Min; Han, Seung; Park, Hee Suk; Son, Ki Chang; Kim, Jung Man; Jung Yung Woo

    1999-11-01

    This report describe a technical transfer under the title of ''A formal design verification and validation on the human factors of a computerized information system in nuclear power plants''. Human factors requirements for the information system designs are extracted from various regulatory and industrial standards and guidelines, and interpreted into a more specific procedures and checklists for verifying the satisfaction of those requirements. A formalized implementation plan is established for human factors verification and validation of a computerized information system in nuclear power plants. Additionally, a Computer support system, named as DIMS-web (design Issue Management System), is developed based upon web internet environment so as to enhance the implementation of the human factors activities. DIMS-Web has three maine functions: supporting requirements review, tracking design issues, and management if issues screening evaluation. DIMS-Web shows its benefits in practice through a trial application to the design review of CFMS for YGN nuclear unit 5 and 6. (author)

  4. Development and validity of a new model for assessing pressure redistribution properties of support surfaces.

    Science.gov (United States)

    Matsuo, Junko; Sugama, Junko; Sanada, Hiromi; Okuwa, Mayumi; Nakatani, Toshio; Konya, Chizuko; Sakamoto, Jirou

    2011-05-01

    Pressure ulcers are a common problem, especially in older patients. In Japan, most institutionalized older people are malnourished and show extreme bony prominence (EBP). EBP is a significant factor in the development of pressure ulcers due to increased interface pressure concentrated at the skin surface over the EBP. The use of support surfaces is recommended for the prophylaxis of pressure ulcers. However, the present equivocal criteria for evaluating the pressure redistribution of support surfaces are inadequate. Since pressure redistribution is influenced by physique and posture, evaluations using human subjects are limited. For this reason, models that can substitute for humans are necessary. We developed a new EBP model based on the anthropometric measurements, including pelvic inclination, of 100 bedridden elderly people. A comparison between the pressure distribution charts of our model and bedridden elderly subjects demonstrated that maximum contact pressure values, buttock contact pressure values, and bone prominence rates corresponded closely. This indicates that the model provides a good approximation of the features of elderly people with EBP. We subsequently examined the validity of the model through quantitative assessment of pressure redistribution functions consisting of immersion, envelopment, and contact area change. The model was able to detect differences in the hardness of urethane foam, differences in the internal pressure of an air mattress, and sequential changes during the pressure switching mode. These results demonstrate the validity of our new buttock model in evaluating pressure redistribution for a variety of surfaces. Copyright © 2010 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.

  5. Modelling and experimental validation for off-design performance of the helical heat exchanger with LMTD correction taken into account

    Energy Technology Data Exchange (ETDEWEB)

    Phu, Nguyen Minh; Trinh, Nguyen Thi Minh [Vietnam National University, Ho Chi Minh City (Viet Nam)

    2016-07-15

    Today the helical coil heat exchanger is being employed widely due to its dominant advantages. In this study, a mathematical model was established to predict off-design works of the helical heat exchanger. The model was based on the LMTD and e-NTU methods, where a LMTD correction factor was taken into account to increase accuracy. An experimental apparatus was set-up to validate the model. Results showed that errors of thermal duty, outlet hot fluid temperature, outlet cold fluid temperature, shell-side pressure drop, and tube-side pressure drop were respectively +-5%, +-1%, +-1%, +-5% and +-2%. Diagrams of dimensionless operating parameters and a regression function were also presented as design-maps, a fast calculator for usage in design and operation of the exchanger. The study is expected to be a good tool to estimate off-design conditions of the single-phase helical heat exchangers.

  6. Effects of newly designed hospital buildings on staff perceptions : a pre-post study to validate design decisions

    NARCIS (Netherlands)

    Schreuder, E.J.A.; Heel, L. van; Goedhart, R.; Dusseldorp, E.; Schraagen, J.M.C.; Burdorf, A.

    2015-01-01

    Objective: This study investigates effects of the newly built nonpatient-related buildings of a large university medical center on staff perceptions and whether the design objectives were achieved. Background: The medical center is gradually renewing its hospital building area of 200,000 m.(2) This

  7. CRITICAL MECHANICAL PROPERTIES OF STRUCTURAL LIGHT-WEIGHT CONCRETE AND THE EFFECTS OF THESE PROPERTIES ON THE DESIGN OF THE PAVEMENT STRUCTURE.

    Science.gov (United States)

    1965-01-01

    In this study, critical mechanical properties of structural lightweight concrete were determined and utilized in the evaluation of a design of concrete pavements. Also presented are the critical mechanical properties resulting from unrestrained and r...

  8. Proposing co-design of personas as a method to heighten validity and engage users

    DEFF Research Database (Denmark)

    Albrechtsen, Charlotte; Pedersen, Majbrit; Pedersen, Nicholai Friis

    2016-01-01

    This paper proposes co-designing personas with users as a strategy to overcome a challenge inherent in the design of personas or fictitious users: On one hand, personas should appear realistic and believable as individuals, and on the other hand, personas should represent a broader range of users....... By involving empirical users in all parts of the process of persona design, the risk of creating personas that are too stereotypical is minimized, as the participating users enrich the data on which the personas are based with up-to-date and firsthand contextual knowledge. Advantages of co-designing personas...... with users is illustrated by a case from higher education in which personas were co-designed with students as part of a project aiming at designing a smartphone application for Master's thesis students. © 2016, IGI Global....

  9. Validity and design of environmental surveillance systems for operating nuclear power plants. Final report

    International Nuclear Information System (INIS)

    Eichholz, G.G.

    1977-12-01

    The composition and procedures of environmental surveillance programs at completed and operating nuclear power plants have been examined with respect to their validity, continuing significance and cost. It was found that many programs contain components that are mainly an extension of preoperational baseline measurements that need not be continued indefinitely and that others lack the statistical validity to make their continued application meaningful. To identify the practical limits imposed by counting statistics and realistic equipment capacity measurements were done on iodine-131 and cesium-137 containing samples to establish detectability limits and proportionate costs for sample preparation and counting. It was found that under commercial conditions effective detectability limits and expected confidence limits were substantially higher than those mentioned in NRC Regulatory Guides. This imposes a need for either selecting fewer samples and counting them for longer times or accepting a lesser accuracy on more samples, within the bounds of reasonable cost per sample

  10. Design of Passive Acoustic Wave Shaping Devices and Their Experimental Validation

    DEFF Research Database (Denmark)

    Christiansen, Rasmus Ellebæk; Sigmund, Ole; Fernandez Grande, Efren

    We discuss a topology optimization based approach for designing passive acoustic wave shaping devices and demonstrate its application to; directional sound emission [1], sound focusing and wave splitting. Optimized devices, numerical and experimental results are presented and benchmarked against...... other designs proposed in the literature. We focus on design problems where the size of the device is on the order of the wavelength, a problematic region for traditional design methods, such as ray tracing.The acoustic optimization problem is formulated in the frequency domain and modeled...

  11. Psychometric properties and convergent and predictive validity of an executive function test battery for two-year-olds

    Directory of Open Access Journals (Sweden)

    Hanna eMulder

    2014-07-01

    Full Text Available Executive function (EF is an important predictor of numerous developmental outcomes, such as academic achievement and behavioral adjustment. Although a plethora of measurement instruments exists to assess executive function in children, only few of these are suitable for toddlers, and even fewer have undergone psychometric evaluation. The present study evaluates the psychometric properties and validity of an assessment battery for measuring EF in two-year-olds. A sample of 2437 children were administered the assessment battery at a mean age of 2;4 years (SD = 0;3 years in a large-scale field study. Measures of both hot EF (snack and gift delay tasks and cool EF (six boxes, memory for location, and visual search task were included. Confirmatory Factor Analyses showed that a two-factor hot and cool EF model fitted the data better than a one-factor model. Measurement invariance was supported across groups differing in age, gender, socioeconomic status (SES, home language, and test setting. Criterion and convergent validity were evaluated by examining relationships between EF and age, gender, SES, home language, and parent and teacher reports of children’s attention and inhibitory control. Predictive validity of the test battery was investigated by regressing children’s pre-academic skills and behavioral problems at age three on the latent hot and cool EF factors at age two years. The test battery showed satisfactory psychometric quality and criterion, convergent, and predictive validity. Whereas cool EF predicted both pre-academic skills and behavior problems one year later, hot EF predicted behavior problems only. These results show that EF can be assessed with psychometrically sound instruments in children as young as two years, and that EF tasks can be reliably applied in large scale field research. The current instruments offer new opportunities for investigating EF in early childhood, and for evaluating interventions targeted at improving

  12. 42 CFR 71.3 - Designation of yellow fever vaccination centers; Validation stamps.

    Science.gov (United States)

    2010-10-01

    ... safe, potent, and pure yellow fever vaccine. Medical facilities of Federal agencies are authorized to obtain yellow fever vaccine without being designated as a yellow fever vaccination center by the Director..., storage, and administration of yellow fever vaccine. If a designated center fails to comply with such...

  13. Design and validation of dynamic hierarchies and adaptive layouts using spatial graph grammars

    NARCIS (Netherlands)

    Liao, K.; Kong, J.; Zhang, K.; de Vries, B.; Griffth, D.A.; Chun, Y.; Dean, D.J.

    2017-01-01

    With the thinking paradigm shifting on the evolution of complex adaptive systems, a pattern-based design approach is reviewed and reinterpreted. Although a variety of long-term and lasting explorations on patterns in geographical analysis, environmental planning, and design exist, in-depth

  14. Design and Experimental Validation of Thick Airfoils for Large Wind Turbines

    DEFF Research Database (Denmark)

    Hrgovan, Iva; Shen, Wen Zhong; Zhu, Wei Jun

    2015-01-01

    In this chapter, two new airfoils with thickness to chord ratios of 30 and 36 % are presented, which were designed with an objective of good aerodynamic and structural features. Airfoil design is based on a direct method using shape perturbation function. The optimization algorithm is coupled wit...

  15. Modeling, design and experimental validation of a small-sized magnetic gear

    NARCIS (Netherlands)

    Zanis, R.; Borisavljevic, A.; Jansen, J.W.; Lomonova, E.A.

    2013-01-01

    A magnetostatic analytical model is created to analyze and design a small-sized magnetic gear for a robotic application. Through a parameter variation study, it is found that the inner rotor magnet height is highly influential to the torque, and based on which, the design is performed. Several

  16. Empirical validation of characteristics of design-based learning in higher education

    NARCIS (Netherlands)

    Gómez Puente, S.M.; Eijck, van M.W.; Jochems, W.M.G.

    2013-01-01

    Design-based learning (DBL) is an educational approach in which students gather and process theoretical knowledge while working on the design of artifacts, systems, and innovative solutions in project settings. Whereas DBL has been employed in the practice of teaching science in secondary education,

  17. Design methodology for the robotic milking barn : modelling, simulation, validation and optimization

    NARCIS (Netherlands)

    Halachmi, I.

    1999-01-01

    The traditional barn design is a milking parlour oriented. To integrate a milking robot the barn should be redesigned according to the robotic milking concept. The entire system (barn design, feeding and cow-traffic routines, management practices) should encourage 'voluntary milking', i.e.,

  18. Nuclear power station: validation of a method for designing operation mimic diagrams

    International Nuclear Information System (INIS)

    Colard, M.I.; De Vlaminck, M.; Javaux, D.

    1995-01-01

    This is the first time in a Belgium nuclear power station that the design of mimic diagrams has involved biotechnologists. The methodology is based upon task analysis, the formalism of which has been evaluated. It is now integrated in the Dimos assisted supervision system to produce the final design of mimic diagram images. (authors). 3 figs., 3 refs

  19. Preliminary design of the Neutron Spectral Shifter that is dedicated to the IFMIF Liquid Breeder Validation Module

    Energy Technology Data Exchange (ETDEWEB)

    Mas, A., E-mail: amassanchez@gmail.com; Mota, F.; Casal, N.; García, A.; Rapisarda, D.; Arroyo, J.M.; Molla, J.; Ibarra, A.

    2014-10-15

    The International Fusion Materials Irradiation Facility (IFMIF) has a D-Li neutron stripping source that provides typical fusion irradiation conditions for material testing. The Liquid Breeder Validation Module (LBVM) is one of the medium flux test modules of the IFMIF that is used to account for some of the DEMO liquid breeder blanket R and D needs. Previous analyses have shown that the main irradiation parameters (He (appm)/dpa and H (appm)/dpa) in the medium flux area of the IFMIF can be improved to fit the expected parameters in the DEMO reactor for functional materials of liquid breeder blankets. Therefore, the design of an additional module, called the Neutron Spectral Shifter (NSS), has been considered to optimize the irradiation conditions of LBVM experiments. The proposed concept consists of supported tungsten plates working as a shifter material inside a steel structure. This design assures the mechanical integrity of the different components and it fulfills the neutronic requirements as well as the cooling capability. This present paper summarizes the work devoted to the design of the LBVM Neutron Spectral Shifter as well as the results of neutronic, thermo-hydraulic, mechanical and safety studies carried out to validate the design.

  20. The design organization test: further demonstration of reliability and validity as a brief measure of visuospatial ability.

    Science.gov (United States)

    Killgore, William D S; Gogel, Hannah

    2014-01-01

    Neuropsychological assessments are frequently time-consuming and fatiguing for patients. Brief screening evaluations may reduce test duration and allow more efficient use of time by permitting greater attention toward neuropsychological domains showing probable deficits. The Design Organization Test (DOT) was initially developed as a 2-min paper-and-pencil alternative for the Block Design (BD) subtest of the Wechsler scales. Although initially validated for clinical neurologic patients, we sought to further establish the reliability and validity of this test in a healthy, more diverse population. Two alternate versions of the DOT and the Wechsler Abbreviated Scale of Intelligence (WASI) were administered to 61 healthy adult participants. The DOT showed high alternate forms reliability (r = .90-.92), and the two versions yielded equivalent levels of performance. The DOT was highly correlated with BD (r = .76-.79) and was significantly correlated with all subscales of the WASI. The DOT proved useful when used in lieu of BD in the calculation of WASI IQ scores. Findings support the reliability and validity of the DOT as a measure of visuospatial ability and suggest its potential worth as an efficient estimate of intellectual functioning in situations where lengthier tests may be inappropriate or unfeasible.

  1. Solid Waste Operations Complex W-113, Detail Design Report (Title II). Volume 5: Design validation assessments and lists

    International Nuclear Information System (INIS)

    1995-09-01

    The Solid Waste Retrieval Facility--Phase 1 (Project W113) will provide the infrastructure and the facility required to retrieve from Trench 04, Burial ground 4C, contact handled (CH) drums and boxes at a rate that supports all retrieved TRU waste batching, treatment, storage, and disposal plans. This includes (1) operations related equipment and facilities, viz., a weather enclosure for the trench, retrieval equipment, weighing, venting, obtaining gas samples, overpacking, NDE, NDA, shipment of waste and (2) operations support related facilities, viz., a general office building, a retrieval staff change facility, and infrastructure upgrades such as supply and routing of water, sewer, electrical power, fire protection, roads, and telecommunication. Title I design for the operations related equipment and facilities was performed by Raytheon/BNFL, and that for the operations support related facilities including infrastructure upgrade was performed by KEH. These two scopes were combined into an integrated W113 Title II scope that was performed by Raytheon/BNFL. The following Code Evaluation analyzes the applicable sections of the National Fire Protection Association (NFPA) 101, Life Safety Code, 1994 Edition and the 1994 Edition of the Uniform Building Code (UBC) to the W113 Trench Enclosure. A Building Code Analysis generally establishes four primary design criteria: occupancy classification; separation requirements; egress requirements; and construction type. The UBC establishes requirements for all criteria. This analysis is limited to the Trench Enclosure Building. The General Office Building and the Retrieval Staff Change Building is not within the scope of this analysis

  2. Reliable and cost effective design of intermetallic Ni2Si nanowires and direct characterization of its mechanical properties.

    Science.gov (United States)

    Han, Seung Zeon; Kang, Joonhee; Kim, Sung-Dae; Choi, Si-Young; Kim, Hyung Giun; Lee, Jehyun; Kim, Kwangho; Lim, Sung Hwan; Han, Byungchan

    2015-10-12

    We report that a single crystal Ni2Si nanowire (NW) of intermetallic compound can be reliably designed using simple three-step processes: casting a ternary Cu-Ni-Si alloy, nucleate and growth of Ni2Si NWs as embedded in the alloy matrix via designing discontinuous precipitation (DP) of Ni2Si nanoparticles and thermal aging, and finally chemical etching to decouple the Ni2Si NWs from the alloy matrix. By direct application of uniaxial tensile tests to the Ni2Si NW we characterize its mechanical properties, which were rarely reported in previous literatures. Using integrated studies of first principles density functional theory (DFT) calculations, high-resolution transmission electron microscopy (HRTEM), and energy-dispersive X-ray spectroscopy (EDX) we accurately validate the experimental measurements. Our results indicate that our simple three-step method enables to design brittle Ni2Si NW with high tensile strength of 3.0 GPa and elastic modulus of 60.6 GPa. We propose that the systematic methodology pursued in this paper significantly contributes to opening innovative processes to design various kinds of low dimensional nanomaterials leading to advancement of frontiers in nanotechnology and related industry sectors.

  3. Active debris removal GNC challenges over design and required ground validation

    Science.gov (United States)

    Colmenarejo, Pablo; Avilés, Marcos; di Sotto, Emanuele

    2015-06-01

    Because of the exponential growth of space debris, the access to space in the medium-term future is considered as being seriously compromised, particularly within LEO polar Sun-synchronous orbits and within geostationary orbits. The active debris removal (ADR) application poses new and challenging requirements on: first, the new required Guidance, Navigation and Control (GNC) technologies and, second, how to validate these new technologies before being applied in real missions. There is no doubt about the strong safety and collision risk aspects affecting the real operational ADR missions. But it shall be considered that even ADR demonstration missions will be affected by significant risk of collision during the demonstration, and that the ADR GNC systems/technologies to be used shall be well mature before using/demonstrating them in space. Specific and dedicated on-ground validation approaches, techniques and facilities are mandatory. The different ADR techniques can be roughly catalogued in three main groups (rigid capture, non-rigid capture and contactless). All of them have a strong impact on the GNC system of the active vehicle during the capture/proximity phase and, particularly, during the active vehicle/debris combo control phase after capture and during the de-orbiting phase. The main operational phases on an ADR scenario are: (1) ground controlled phase (ADR vehicle and debris are far), (2) fine orbit synchronization phase (ADR vehicle to reach debris ±V-bar), (3) short range phase (along track distance reduction till 10-100 s of metres), (4) terminal approach/capture phase and (5) de-orbiting. While phases 1-3 are somehow conventional and already addressed in detail during past/on-going studies related to rendezvous and/or formation flying, phases 4-5 are very specific and not mature in terms of GNC needed technologies and HW equipment. GMV is currently performing different internal activities and ESA studies/developments related to ADR mission, GNC and

  4. Microcomputer-based tests for repeated-measures: Metric properties and predictive validities

    Science.gov (United States)

    Kennedy, Robert S.; Baltzley, Dennis R.; Dunlap, William P.; Wilkes, Robert L.; Kuntz, Lois-Ann

    1989-01-01

    A menu of psychomotor and mental acuity tests were refined. Field applications of such a battery are, for example, a study of the effects of toxic agents or exotic environments on performance readiness, or the determination of fitness for duty. The key requirement of these tasks is that they be suitable for repeated-measures applications, and so questions of stability and reliability are a continuing, central focus of this work. After the initial (practice) session, seven replications of 14 microcomputer-based performance tests (32 measures) were completed by 37 subjects. Each test in the battery had previously been shown to stabilize in less than five 90-second administrations and to possess retest reliabilities greater than r = 0.707 for three minutes of testing. However, all the tests had never been administered together as a battery and they had never been self-administered. In order to provide predictive validity for intelligence measurement, the Wechsler Adult Intelligence Scale-Revised and the Wonderlic Personnel Test were obtained on the same subjects.

  5. Steps toward validity in active living research: research design that limits accusations of physical determinism.

    Science.gov (United States)

    Riggs, William

    2014-03-01

    "Active living research" has been accused of being overly "physically deterministic" and this article argues that urban planners must continue to evolve research and address biases in this area. The article first provides background on how researchers have dealt with the relationship between the built environment and health over years. This leads to a presentation of how active living research might be described as overly deterministic. The article then offers lessons for researchers planning to embark in active-living studies as to how they might increase validity and minimize criticism of physical determinism. © 2013 Published by Elsevier Ltd.

  6. Design and Validation of a Rubric to Assess the Use of American Psychological Association Style in scientific articles

    Directory of Open Access Journals (Sweden)

    Gladys Merma Molina

    2017-01-01

    Full Text Available In this study, the researchers will explore the process of designing and validating a rubric to evaluate the adaptation of scientific articles in the format of the American Psychological Association (APA. The rubric will evaluate certain aspects of the APA format that allow authors, editors, and evaluators to decide if the scientific article is coherent with these rules. Overall, the rubric will concentrate on General Aspects of the article and on the Citation System. To do this, 10 articles that were published within 2012-2016 and included in the Journal Citation Report will be analyzed using technical expertise. After doing 5 pilot studies, the results showed the validity and the reliability of the instrument. Furthermore, the process showed the evidence of the possibilities of the rubric to contribute to uniform criteria that can be used as a didactic tool in different scenarios.

  7. Design and validation of a morphing myoelectric hand posture controller based on principal component analysis of human grasping.

    Science.gov (United States)

    Segil, Jacob L; Weir, Richard F ff

    2014-03-01

    An ideal myoelectric prosthetic hand should have the ability to continuously morph between any posture like an anatomical hand. This paper describes the design and validation of a morphing myoelectric hand controller based on principal component analysis of human grasping. The controller commands continuously morphing hand postures including functional grasps using between two and four surface electromyography (EMG) electrodes pairs. Four unique maps were developed to transform the EMG control signals in the principal component domain. A preliminary validation experiment was performed by 10 nonamputee subjects to determine the map with highest performance. The subjects used the myoelectric controller to morph a virtual hand between functional grasps in a series of randomized trials. The number of joints controlled accurately was evaluated to characterize the performance of each map. Additional metrics were studied including completion rate, time to completion, and path efficiency. The highest performing map controlled over 13 out of 15 joints accurately.

  8. The Effects of the Properties of Gases on the Design of Bubble Columns Equipped with a Fine Pore Sparger

    Directory of Open Access Journals (Sweden)

    Athanasios G. Kanaris

    2018-03-01

    Full Text Available This work concerns the performance of bubble columns equipped with porous sparger and investigates the effect of gas phase properties by conducting experiments with various gases (i.e., air, CO2, He that cover a wide range of physical property values. The purpose is to investigate the validity of the design equations, which were proposed in our previous work and can predict with reasonable accuracy the transition point from homogeneous to heterogeneous regime as well as the gas holdup and the mean Sauter diameter at the homogeneous regime. Although, the correlations were checked with data obtained using different geometrical configurations and several Newtonian and non-Newtonian liquids, as well as the addition of surfactants, the gas phase was always atmospheric air. The new experiments revealed that only the use of low-density gas (He has a measurable effect on bubble column performance. More precisely, when the low-density gas (He is employed, the transition point shifts to higher gas flow rates and the gas holdup decreases, a fact attributed to the lower momentum force exerted by the gas. In view of the new data, the proposed correlations have been slightly modified to include the effect of gas phase properties and it is found that they can predict the aforementioned quantities with an accuracy of ±15%. It has been also proved that computational fluid dynamics (CFD simulations are an accurate means for assessing the flow characteristics inside a bubble column.

  9. Comparison of Crack Growth Test Results at Elevated Temperature and Design Code Material Properties for Grade 91 Steel

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hyeong-Yeon; Kim, Woo-Gon; Kim, Nak-Hyun [Korea Atomic Energy Reserach Institute, Daejeon (Korea, Republic of)

    2015-01-15

    The material properties of crack growth models at an elevated temperature were derived from the results of numerous crack growth tests for Mod.9Cr-1Mo (ASME Grade 91) steel specimens under fatigue loading and creep loading at an elevated temperature. These crack growth models were needed for defect assessment under creep-fatigue loading. The mathematical crack growth rate models for fatigue crack growth (FCG) and creep crack growth (CCG) were determined based on the test results, and the models were compared with those of the French design code RCCMRx to investigate the conservatism of the code. The French design code RCC-MRx provides an FCG model and a CCG model for Grade 91 steel in Section III Tome 6. It was shown that the FCG model of RCC-MRx is conservative, while the CCG model is non-conservative compared with the present test data. Thus, it was shown that further validation of the property was required. Mechanical strength tests and creep tests were also conducted, and the test results were compared with those of RCC-MRx.

  10. Experimental validation of new empirical models of the thermal properties of food products for safe shipping

    Science.gov (United States)

    Hamid, Hanan H.; Mitchell, Mark; Jahangiri, Amirreza; Thiel, David V.

    2018-04-01

    Temperature controlled food transport is essential for human safety and to minimise food waste. The thermal properties of food are important for determining the heat transfer during the transient stages of transportation (door opening during loading and unloading processes). For example, the temperature of most dairy products must be confined to a very narrow range (3-7 °C). If a predefined critical temperature is exceeded, the food is defined as spoiled and unfit for human consumption. An improved empirical model for the thermal conductivity and specific heat capacity of a wide range of food products was derived based on the food composition (moisture, fat, protein, carbohydrate and ash). The models that developed using linear regression analysis were compared with the published measured parameters in addition to previously published theoretical and empirical models. It was found that the maximum variation in the predicated thermal properties leads to less than 0.3 °C temperature change. The correlation coefficient for these models was 0.96. The t-Stat test ( P-value >0.99) demonstrated that the model results are an improvement on previous works. The transient heat transfer based on the food composition and the temperature boundary conditions was found for a Camembert cheese (short cylindrical shape) using a multiple dimension finite difference method code. The result was verified using the heat transfer today (HTT) educational software which is based on finite volume method. The core temperature rises from the initial temperature (2.7 °C) to the maximum safe temperature in ambient air (20.24 °C) was predicted to within about 35.4 ± 0.5 min. The simulation results agree very well ( +0.2 °C) with the measured temperature data. This improved model impacts on temperature estimation during loading and unloading the trucks and provides a clear direction for temperature control in all refrigerated transport applications.

  11. LEGAL CERTAINTY OF INDUSTRIAL DESIGN REVENUE IN INDONESIA BASED ON INTELLECTUAL PROPERTY APPROACH AND LEGAL COMPARISON

    Directory of Open Access Journals (Sweden)

    Ranti Fauza Mayana

    2018-03-01

    Full Text Available [Legal Certainty Of Industrial Design Revenue  In Indonesia Based On Intellectual Property Approach And Legal Comparison]  Protection of Industrial Designs, as well as intellectual property, is based on the ability of human creativity through creativity, taste and intention. According to Article 25 paragraph (1 TRIPs Protected Industrial Design Agreement is a new or original Industrial Design, this provision holds the principle that the novelty of a design is obtained when the design is differ from the previous, the novelty includes novelty and originality, the principal basis for the grant of Industrial Design, whereas this principle is not fully adopted in the provisions of Industrial Design. The Industrial Design Decree in Indonesia only requires novelty without clarifying how to interpret the novelty requirement so that a large number of Industrial Design Rights are obtained based on the Minor Change approach where slight differences in form and configuration have essentially demonstrated novelty. The minor change approach is considered to exclude the aspect of originality and is less able to provide legal certainty to the holder of the registered Industrial Design Rights. This paper aims to explore minor change approach as the basis for the evaluation of the novelty of Industrial Design in the perspective of comparative law in several countries of the world, namely the United States, Japan, the European Union and Australia as a study and reference material in an effort to establish protection of Industrial Design Rights in Indonesia that can provide legal certainty. Keywords: Industrial Design Revenue, Comparative Law.

  12. Design, synthesis and photovoltaic properties of a series of new acceptor-pended conjugated polymers

    Institute of Scientific and Technical Information of China (English)

    Zhihong; Wu; Yongxiang; Zhu; Wei; Li; Yunping; Huang; Junwu; Chen; Chunhui; Duan; Fei; Huang; Yong; Cao

    2016-01-01

    A series of novel acceptor-pended conjugated polymers featuring a newly developed carbazole-derived unit are designed and synthesized. The relationships between chemical structure and optoelectronic properties of the polymers are systematically investigated.The control of UV-Vis absorption spectra and energy levels in resulting polymers are achieved by introducing suitable pended acceptor units. The photovoltaic properties of the resulting polymers are evaluated by blending the polymers with(6,6)-phenyl-C71-butyric acid methyl ester. The resulting solar cells exhibit moderate performances with high open-circuit voltage. Charge transport properties and morphology were investigated to understand the performance of corresponding solar cells.

  13. Using the properties of organic compounds to help design a treatment system

    International Nuclear Information System (INIS)

    Nyer, E.; Boettcher, G.; Morello, B.

    1991-01-01

    The author provides the physical/chemical and treatability properties of 50 organic compounds. The physical/chemical parameters of the compounds can be used to help evaluate data generated during remedial investigations. The treatability parameters can be used as a basis for the preliminary design of a treatment system that will remove organic compounds from ground water. The main physical/chemical properties that should be evaluated prior to design are solubility, specific gravity, and octanol/water coefficient. Based on this determination, the treatability is determined for carbon adsorption and biodegradability

  14. [Design and validation of a questionnaire to assess dietary behavior in Mexican students in the area of health].

    Science.gov (United States)

    Márquez-Sandoval, Yolanda Fabiola; Salazar-Ruiz, Erika Nohemi; Macedo-Ojeda, Gabriela; Altamirano-Martínez, Macedo-Ojeda; Bernal-Orozco, María Fernanda; Salas-Salvadó, Jordi; Vizmanos-Lamotte, Barbara

    2014-07-01

    The dietary behavior (DB) establishes the relationship between the human being and foods and has an influence on nutrient intake and, therefore, it contributes to the health or disease status of a population, even among college students. There exit some validated instruments to assess food and nutrients intake, but there are very few assessing DB. To design and validate a questionnaire to assess DB in Mexican college students. According to the literature and Reasoned Theory, a questionnaire assessing DB was designed. Its logic and content validity was determined by expert assessment. It was applied on two occasions with a 4-week interval to 333 students from the University of Guadalajara coursing the sixth semester of Medicine or Nutrition. The reproducibility was assessed by means of the interclass correlation coefficient. The construct validity and the internal consistency were calculated by Rasch analysis, for both the difficulty of the items and the subjects' capability. The questionnaire finally included 31 questions with multiple choice answers. The interclass correlation coefficient of the instrument was 0.76. The Cronbach alpha was 0.50 for the subjects' capability and 0.98 for the internal consistency of the items. 87.1% of the subjects and 89.8% of the items had INFIT and OUTFIT values within acceptable limits. The present questionnaire has the potentiality of measuring at low cost and in a practical way aspects related with DB in college student with the aim of establishing or following-up corrective or preventive actions. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  15. Self-administered structured food record for measuring individual energy and nutrient intake in large cohorts: Design and validation.

    Science.gov (United States)

    García, Silvia M; González, Claudio; Rucci, Enzo; Ambrosino, Cintia; Vidal, Julia; Fantuzzi, Gabriel; Prestes, Mariana; Kronsbein, Peter

    2018-06-05

    Several instruments developed to assess dietary intake of groups or populations have strengths and weaknesses that affect their specific application. No self-administered, closed-ended dietary survey was previously used in Argentina to assess current food and nutrient intake on a daily basis. To design and validate a self-administered, structured food record (NutriQuid, NQ) representative of the adult Argentine population's food consumption pattern to measure individual energy and nutrient intake. Records were loaded onto a database using software that checks a regional nutrition information system (SARA program), automatically quantifying energy and nutrient intake. NQ validation included two phases: (1) NQ construct validity comparing records kept simultaneously by healthy volunteers (45-75 years) and a nutritionist who provided meals (reference), and (2) verification of whether NQ reflected target population consumption (calories and nutrients), week consumption differences, respondent acceptability, and ease of data entry/analysis. Data analysis included descriptive statistics, repeated measures ANOVA, intraclass correlation coefficient, nonparametric regression, and cross-classification into quintiles. The first validation (study group vs. reference) showed an underestimation (10%) of carbohydrate, fat, and energy intake. Second validation: 109 volunteers (91% response) completed the NQ for seven consecutive days. Record completion took about 9min/day, and data entry 3-6min. Mean calorie intake was 2240±119kcal/day (42% carbohydrates, 17% protein, and 41% fat). Intake significantly increased in the weekend. NQ is a simple and efficient tool to assess dietary intake in large samples. Copyright © 2018 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Utilizing job/task analysis to establish content validity in the design of training programs

    Energy Technology Data Exchange (ETDEWEB)

    Nay, W.E.

    1988-01-01

    The decade of the 1980's has been a turbulent time for the Department of Energy. With concern mounting about the terrorist threat, a wave of congressional inquiries and internal inspections crossed the nation and engulfed many of the nuclear laboratories and facilities operated by DOE contractors. A typical finding was the need to improve, and increase, the training of the protective force. The immediate reaction resulted in a wide variety of responses, with most contractors feeling safer with too much, rather than not enough training. As soon as the initial pressures to upgrade subsided, a task force was established to evaluate the overall training needs. Representatives from the contractor facilities worked together to conduct a job analysis of the protective force. A generic task inventory was established, and validated at the different sites. This list has been invaluable for determining the tasks, conditions, and standards needed to develop well stated learning objectives. The enhanced training programs are being refined to ensure job content validity based on the data collected.

  17. Design and experimental validation of the inlet guide vane system of a mini hydraulic bulb-turbine

    Energy Technology Data Exchange (ETDEWEB)

    Ferro, L.M.C. [Department of Mechanical Engineering, Escola Superior de Tecnologia de Setubal, Polytechnic Institute of Setubal, Campus do IPS, Estefanilha, 2910-761 Setubal (Portugal); IDMEC, Instituto Superior Tecnico, Technical University of Lisbon, Av. Rovisco Pais,1049-001 Lisboa (Portugal); Gato, L.M.C.; Falcao, A.F.O. [IDMEC, Instituto Superior Tecnico, Technical University of Lisbon, Av. Rovisco Pais,1049-001 Lisboa (Portugal)

    2010-09-15

    The paper presents a fast design method for the inlet guide vanes of low-cost mini hydraulic bulb turbines. The guide vanes are positioned between two conical surfaces with a common vertex and have constant thickness distribution, except close to the leading and the trailing edges. The conical-walled inlet guide vane row is designed using a quasi-three-dimensional calculation method, by prescribing the angular-momentum distribution along the span at the outlet section of the guide vanes. The meridional through-flow is computed by a streamline curvature method and the blade-to-blade flow by a singularity surface method. The stagger angle and the vane camber are computed to fulfil the required design circulation and zero-incidence flow at the leading edge. The final vane shape is a single-curvature surface with straight leading and trailing edges. To validate the design method, a conical-walled inlet guide vane row nozzle-model with six fixed vanes was designed, manufactured and tested in an airflow rig. Traversing measurements along the circumferential and radial directions were made with a five-hole probe. The experimental results are compared with the prescribed design conditions and with numerical results from the three-dimensional inviscid and viscous flow computed with the FLUENT code. (author)

  18. Property Model-based Tailor-made Design of Chemical-based Products

    DEFF Research Database (Denmark)

    Kalakul, Sawitree

    Computer-aided model-based methods and tools are increasingly playing important roles in chemical product design. They have the potential to very quickly search for and identify reliable product candidates that can then be verified through experiments. Inthis way, the time and resources spent...... on experiment are reduced leading to faster and cheaper to market the products. The tools also help to manage the solution of product design problems, which usually require efficient handling of model-data-knowledge from different sources and at different time and size scales. The main contribution...... the needed template for a desired product is not available. VPPD-Lab employs a suite of algorithms(such as database search, molecular and mixture blend design) and toolboxes (such asproperty calculations and property model consistency tests) for specific product property prediction, design, and/or analysis...

  19. Validation of satellite-retrieved MBL cloud properties using DOE ARM AMF measurements at the Azores

    Science.gov (United States)

    Xi, B.; Dong, X.; Minnis, P.; Sun-Mack, S.

    2013-05-01

    Marine Boundary Layer (MBL) cloud properties derived for the Clouds and the Earth's Radiant Energy System (CERES) Project using Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) data are compared with observations taken at the Atmospheric Radiation Measurement (ARM) AMF AZORES site from June 2009 through December 2010. Retrievals from ARM surface-based data were averaged over a 1-hour interval centered at the time of each satellite overpass, and the CERES-MODIS Ed4 cloud properties were averaged within a 30-km x 30-km box centered on the ARM AZORES site. Two datasets were analyzed: all of the single-layered unbroken decks (SL) and those cases without temperature inversions. The CERES-MODIS cloud top/base heights were determined from cloud top/base temperature by using a lapse rate method normalized to the 24-h mean surface air temperature. The preliminary results show: for all SL MBL at daytime, they are, on average, 0.148 km (cloud top) and 0.087 km (cloud base) higher than the ARM radar-lidar observed cloud top and base, respectively. At nighttime, they are 0.446 km (cloud top) and 0.334 km (cloud base). For those cases without temperature inversions, the comparisons are close to their SL counterparts. For cloud temperatures, the MODIS-derived cloud-top and -base temperatures are 1.6 K lower and 0.4 K higher than the surface values with correlations of 0.92 during daytime. At nighttime, the differences are slightly larger and correlations are lower than daytime comparisons. Variations in the height difference are mainly caused by uncertainties in the surface air temperatures and lapse rates. Based on a total of 61 daytime and 87 nighttime samples (ALL SL cases), the temperature inversion layers occur about 72% during daytime and 83% during nighttime. The difference of surface-observed lapse rate and the satellite derived lapse rate can be 1.6 K/km for daytime and 3.3K/km for nighttime. From these lapse rates, we can further analyze the surface

  20. Reproducibility and Validity of a Food Frequency Questionnaire Designed to Assess Diet in Children Aged 4-5 Years.

    Science.gov (United States)

    Vioque, Jesus; Gimenez-Monzo, Daniel; Navarrete-Muñoz, Eva Maria; Garcia-de-la-Hera, Manuela; Gonzalez-Palacios, Sandra; Rebagliato, Marisa; Ballester, Ferran; Murcia, Mario; Iñiguez, Carmen; Granado, Fernando

    2016-01-01

    The food frequency questionnaire (FFQ) is the most efficient and cost-effective method to investigate the relationship between usual diet and disease in epidemiologic studies. Although FFQs have been validated in many adult populations worldwide, the number of valid FFQ in preschool children is very scarce. The aim of this study was to evaluate the reproducibility and validity of a semi-quantitative FFQ designed for children aged 4 to 5 years. In this study, we have included 169 children aged 4-5 years from the INMA project in Valencia, a population-based prospective cohort study of mothers and children in Spain. The 105-items FFQ was administered twice to the parents or care-givers of children over a 9-month period. Reproducibility was explored by comparing intake of nutrients by the FFQs, while validity was examined by comparing the nutrient values from the FFQs with the average nutrient values of three 24 hour dietary recall (24hDR) taken in the period, and also, with the concentration in blood specimens for several vitamins (carotenoids, folate, vitamin B12, vitamin C and α-tocopherol). Pearson correlation coefficients and de-attenuated correlation coefficients were calculated and we also evaluated misclassification by quintile distribution. All correlation coefficients for reproducibility for nutrients and major food groups were statistically significant; the average correlation coefficients for daily intake were 0.43 for food groups and 0.41 for nutrients. The average correlation coefficients for validity for daily intakes against 24hDR was r = 0.30, and the average for de-attenuated correlation coefficients was r = 0.44. When evaluating validity against the blood concentration of vitamins, statistically significant correlations were observed for vitamin C (0.35), lycopene (0.31), β-Cryptoxantin (0.40), and vitamin E (0.29); the average of correlation coefficients was r = 0.21. Despite some low to moderate correlations for reproducibility and validity

  1. Steady-State and Transient Analysis for Design Validation of SMART-ITL Secondary System

    Energy Technology Data Exchange (ETDEWEB)

    Yun, Eunkoo; Bae, Hwang; Ryu, Sung Uk; Jeon, Byong-Guk; Yang, Jin-Hwa; Yi, Sung-Jae; Park, Hyun-Sik [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    SMART can prevent large-break loss of coolant accident (LBLOCA) inherently. SMART-ITL is an experimental simulation facility designed to perform integral effect tests for the SMART plant. In terms of the secondary system of SMART-ITL, the design has been simplified from that of reference plant by replacing several components, such as expansion device and condenser, with an appropriate device to be functional as the alternatives. In this paper, in order to understand the operational characteristics as well as design concept, the secondary system of SMRAT-ITL is analyzed in steady-state and transient aspects, and the results are compared with relevant experimental results. This study focuses on the understanding of thermal-hydraulic behavior of SMART-ITL secondary system, which is simplified from that of reference plant. To identify the behaviors of the secondary system, the steady-state and transient analysis were conducted based on experimental results. In steady-state analysis, the results clearly showed that the system pressure is related to the temperature of condensation tank which varies depending on mixture enthalpy. In transient analysis, the dynamic behavior during heat-up process has been investigated. The results reveal that we can reasonably assume the fluid filled in TK-CD-01 be in a saturated condition. The results showed that the design of SMART-ITL secondary system is appropriate, and the system is being properly operated to match the design intent.

  2. Design-relevant mechanical properties of 316-type stainless steels for superconducting magnets

    Energy Technology Data Exchange (ETDEWEB)

    Tobler, R.L.; Nishimura, A.; Yamamoto, J.

    1996-08-01

    Worldwide interest in austenitic alloys for structural applications in superconducting magnets has led to an expanded database for the 316-type stainless steels. We review the cryogenic mechanical properties of wrought, cast, and welded steels at liquid helium temperature (4 K), focussing on aspects of material behavior relevant to magnet design. Fracture mechanics parameters essential to structural reliability assessments are presented, including strength, toughness, and fatigue parameters that are critical for some component designs. (author). 105 refs.

  3. On some properties of bone functional adaptation phenomenon useful in mechanical design.

    Science.gov (United States)

    Nowak, Michał

    2010-01-01

    The paper discusses some unique properties of trabecular bone functional adaptation phenomenon, useful in mechanical design. On the basis of the biological process observations and the principle of constant strain energy density on the surface of the structure, the generic structural optimisation system has been developed. Such approach allows fulfilling mechanical theorem for the stiffest design, comprising the optimisations of size, shape and topology, using the concepts known from biomechanical studies. Also the biomimetic solution of multiple load problems is presented.

  4. Design-relevant mechanical properties of 316-type stainless steels for superconducting magnets

    International Nuclear Information System (INIS)

    Tobler, R.L.; Nishimura, A.; Yamamoto, J.

    1996-08-01

    Worldwide interest in austenitic alloys for structural applications in superconducting magnets has led to an expanded database for the 316-type stainless steels. We review the cryogenic mechanical properties of wrought, cast, and welded steels at liquid helium temperature (4 K), focussing on aspects of material behavior relevant to magnet design. Fracture mechanics parameters essential to structural reliability assessments are presented, including strength, toughness, and fatigue parameters that are critical for some component designs. (author). 105 refs

  5. Validation of quasi-invariant ice cloud radiative quantities with MODIS satellite-based cloud property retrievals

    International Nuclear Information System (INIS)

    Ding, Jiachen; Yang, Ping; Kattawar, George W.; King, Michael D.; Platnick, Steven; Meyer, Kerry G.

    2017-01-01

    Similarity relations applied to ice cloud radiance calculations are theoretically analyzed and numerically validated. If τ(1–ϖ) and τ(1–ϖg) are conserved where τ is optical thickness, ϖ the single-scattering albedo, and g the asymmetry factor, it is possible that substantially different phase functions may give rise to similar radiances in both conservative and non-conservative scattering cases, particularly in the case of large optical thicknesses. In addition to theoretical analysis, this study uses operational ice cloud optical thickness retrievals from the Moderate Resolution Imaging Spectroradiometer (MODIS) Level 2 Collection 5 (C5) and Collection 6 (C6) cloud property products to verify radiative similarity relations. It is found that, if the MODIS C5 and C6 ice cloud optical thickness values are multiplied by their respective (1–ϖg) factors, the resultant products referred to as the effective optical thicknesses become similar with their ratio values around unity. Furthermore, the ratios of the C5 and C6 ice cloud effective optical thicknesses display an angular variation pattern similar to that of the corresponding ice cloud phase function ratios. The MODIS C5 and C6 values of ice cloud similarity parameter, defined as [(1–ϖ)/(1–ϖg)]"1"/"2, also tend to be similar. - Highlights: • Similarity relations are theoretically analyzed and validated. • Similarity relations are verified with the MODIS Level 2 Collection 5 and 6 ice cloud property products. • The product of ice cloud optical thickness and (1–ϖg) is approximately invariant. • The similarity parameter derived from the MODIS ice cloud effective radius retrieval tends to be invariant.

  6. Shoulder pain and disability index: cross cultural validation and evaluation of psychometric properties of the Spanish version.

    Science.gov (United States)

    Membrilla-Mesa, Miguel David; Cuesta-Vargas, Antonio Ignacio; Pozuelo-Calvo, Rocio; Tejero-Fernández, Victor; Martín-Martín, Lydia; Arroyo-Morales, Manuel

    2015-12-21

    The Shoulder Pain Disability Index (SPADI) is a recently published but widely used outcome measure. This study included 136 patients with shoulder disorders. SPADI was first translated and back-translated and then subjected to psychometric validation. Participants completed the Spanish versions of the SPADI, general health (SF-12), the Simple Shoulder Test (SST), Disability of Arm, Shoulder, and Hand (DASH) questionnaires and a pain intensity visual analog scale (VAS). The factors explained 62.8 % of the variance, with an internal consistency of α = 0.916 and 0.860, respectively. The confirmatory factor analysis showed a Comparative Fit Index of 0.82 and a Normed Fit Index of 0.80. The Root Mean Square Error of Aproximation was 0.12. The x (2) test for the 2-factor model was significant (x (2) = 185.41, df = 62, p validity analysis, strong positive correlations were observed between Spanish Version of the SPADI and DASH (pain: r = 0.80; p Spanish Version of the SPADI and VAS (pain: r = 0.67; p Spanish Version of the SPADI and SST-Sp (pain: r = -0.71; p Spanish Version of the SPADI was only weakly correlated with physical and mental components of SF-12 (both r = 0.40; p Spanish version of SPADI demonstrated satisfactory psychometric properties in a patient sample in the hospital setting.

  7. Design and Validation of Optimized Feedforward with Robust Feedback Control of a Nuclear Reactor

    International Nuclear Information System (INIS)

    Shaffer, Roman; He Weidong; Edwards, Robert M.

    2004-01-01

    Design applications for robust feedback and optimized feedforward control, with confirming results from experiments conducted on the Pennsylvania State University TRIGA reactor, are presented. The combination of feedforward and feedback control techniques complement each other in that robust control offers guaranteed closed-loop stability in the presence of uncertainties, and optimized feedforward offers an approach to achieving performance that is sometimes limited by overly conservative robust feedback control. The design approach taken in this work combines these techniques by first designing robust feedback control. Alternative methods for specifying a low-order linear model and uncertainty specifications, while seeking as much performance as possible, are discussed and evaluated. To achieve desired performance characteristics, the optimized feedforward control is then computed by using the nominal nonlinear plant model that incorporates the robust feedback control

  8. The sustainability effects of Product/Service-System design validated through Life Cycle Assessment

    DEFF Research Database (Denmark)

    Smidt Dreijer, Leise; Birkved, Morten; Howard, Thomas J.

    2013-01-01

    and lifts. The major research question for the case is how the supplier’s continued ownership of the building materials influences the sustainability of such buildings. By using a PSS design approach in the early design stages, the architects involved in the case project were able to make design decisions......Temporary buildings are generally considered to be unsustainable due to a short life span of the materials applied in the building. The construction materials typically have a longer use life than the required use life of the building, thus functioning building materials are often discarded after...... the demolition. In an attempt to improve the sustainability of temporary buildings, a Product/Service-System (PSS) strategy is here applied to a case project. The case project concerns a temporary building made of leased materials and building components such as shipping containers, scaffolding materials...

  9. Tritium processing tests for the validation of upgraded PERMCAT mechanical design

    Energy Technology Data Exchange (ETDEWEB)

    Demange, D.; Glugla, M.; Guenther, K.; Le, T. L.; Simon, K. H.; Wagner, R.; Welte, S. [Forschungszentrum Karlsruhe GmbH, Institue for Technical Physics, Tritium Laboratory Karlsruhe, P.O Box 36 40, D-76021 Karlsruhe (Germany)

    2008-07-15

    The PERMCAT process, chosen for the final clean-up stage of the Tritium Exhaust Processing system in ITER, directly combines a Pd/Ag membrane and a catalyst bed for the detritiation of gaseous mixtures containing molecular and chemically bound tritium. Upgraded PERMCAT mechanical designs have been proposed to both increase the robustness and simplify the design of the reactor. One uses a special corrugated Pd/Ag membrane able to withstand change in length of the membrane during both normal operation and in the case of off-normal events. Based on this design, an upgraded PERMCAT reactor has been produced at FZK and successfully tested at TLK with ITER relevant tritiated gaseous mixtures using the CAPER facility. (authors)

  10. Tritium processing tests for the validation of upgraded PERMCAT mechanical design

    International Nuclear Information System (INIS)

    Demange, D.; Glugla, M.; Guenther, K.; Le, T. L.; Simon, K. H.; Wagner, R.; Welte, S.

    2008-01-01

    The PERMCAT process, chosen for the final clean-up stage of the Tritium Exhaust Processing system in ITER, directly combines a Pd/Ag membrane and a catalyst bed for the detritiation of gaseous mixtures containing molecular and chemically bound tritium. Upgraded PERMCAT mechanical designs have been proposed to both increase the robustness and simplify the design of the reactor. One uses a special corrugated Pd/Ag membrane able to withstand change in length of the membrane during both normal operation and in the case of off-normal events. Based on this design, an upgraded PERMCAT reactor has been produced at FZK and successfully tested at TLK with ITER relevant tritiated gaseous mixtures using the CAPER facility. (authors)

  11. Design and validation of an improved graphical user interface with the 'Tool ball'.

    Science.gov (United States)

    Lee, Kuo-Wei; Lee, Ying-Chu

    2012-01-01

    The purpose of this research is introduce the design of an improved graphical user interface (GUI) and verifies the operational efficiency of the proposed interface. Until now, clicking the toolbar with the mouse is the usual way to operate software functions. In our research, we designed an improved graphical user interface - a tool ball that is operated by a mouse wheel to perform software functions. Several experiments are conducted to measure the time needed to operate certain software functions with the traditional combination of "mouse click + tool button" and the proposed integration of "mouse wheel + tool ball". The results indicate that the tool ball design can accelerate the speed of operating software functions, decrease the number of icons on the screen, and enlarge the applications of the mouse wheel. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  12. Spreadsheet design and validation for characteristic limits determination in gross alpha and beta measurement

    International Nuclear Information System (INIS)

    Prado, Rodrigo G.P. do; Dalmazio, Ilza

    2013-01-01

    The identification and detection of ionizing radiation are essential requisites of radiation protection. Gross alpha and beta measurements are widely applied as a screening method in radiological characterization, environmental monitoring and industrial applications. As in any other analytical technique, test performance depends on the quality of instrumental measurements and reliability of calculations. Characteristic limits refer to three specific statistics, namely, decision threshold, detection limit and confidence interval, which are fundamental to ensuring the quality of determinations. This work describes a way to calculate characteristic limits for measurements of gross alpha and beta activity applying spreadsheets. The approach used for determination of decision threshold, detection limit and limits of the confidence interval, the mathematical expressions of measurands and uncertainty followed standards guidelines. A succinct overview of this approach and examples are presented and spreadsheets were validated using specific software. Furthermore, these spreadsheets could be used as tool to instruct beginner users of methods for ionizing radiation measurements. (author)

  13. [Evaluation of Significant Autobiographical Memories Scale: Design and structural validation at an exploratory level].

    Science.gov (United States)

    Lolich, María; Azzollini, Susana

    2016-11-01

    Personal memories are multimodal cognitive representations. Nowadays, psychometric instruments which aim to assess signifcant memories phenomenological features are scarce. Consequently, the Evaluation of Signifcant Autobiographical Memories Scale was constructed and structural validated at an exploratory level. A total of 404 individuals from Buenos Aires city (Argentina) participated in the research. Initially, an expert judgment and a pilot study administration were carried out. Next, a homogeneity and a principal components analysis were implemented. To assess the scale reliability, Cronbach's alphas coefficients were analyzed. The fnal version has 30 Likert response items gathered in 8 dimensions. Satisfactory psychometric proprieties were obtained - internal consistency of .892 and a total explained variance of 65.78%. The scale provides two main scores regarding the total quantity and intensity of the phenomenological components as well as a partial score per each dimension. It is stated that the test will prove to be useful in the research feld as well as in the clinical area.

  14. Design, Manufacturing and Experimental Validation of Optical Fiber Sensors Based Devices for Structural Health Monitoring

    Directory of Open Access Journals (Sweden)

    Angela CORICCIATI

    2016-06-01

    Full Text Available The use of optical fiber sensors is a promising and rising technique used for Structural Health Monitoring (SHM, because permit to monitor continuously the strain and the temperature of the structure where they are applied. In the present paper three different types of smart devices, that are composite materials with an optical fiber sensor embedded inside them during the manufacturing process, are described: Smart Patch, Smart Rebar and Smart Textile, which are respectively a plate for local exterior intervention, a rod for shear and flexural interior reinforcement and a textile for an external whole application. In addition to the monitoring aim, the possible additional function of these devices could be the reinforcement of the structures where they are applied. In the present work, after technology manufacturing description, the experimental laboratory characterization of each device is discussed. At last, smart devices application on medium scale masonry walls and their validation by mechanical tests is described.

  15. Methodology for the nuclear design validation of an Alternate Emergency Management Centre (CAGE)

    Science.gov (United States)

    Hueso, César; Fabbri, Marco; de la Fuente, Cristina; Janés, Albert; Massuet, Joan; Zamora, Imanol; Gasca, Cristina; Hernández, Héctor; Vega, J. Ángel

    2017-09-01

    The methodology is devised by coupling different codes. The study of weather conditions as part of the data of the site will determine the relative concentrations of radionuclides in the air using ARCON96. The activity in the air is characterized depending on the source and release sequence specified in NUREG-1465 by RADTRAD code, which provides results of the inner cloud source term contribution. Known activities, energy spectra are inferred using ORIGEN-S, which are used as input for the models of the outer cloud, filters and containment generated with MCNP5. The sum of the different contributions must meet the conditions of habitability specified by the CSN (Spanish Nuclear Regulatory Body) (TEDE validated.

  16. Design and Validation of CRISPR/Cas9 Systems for Targeted Gene Modification in Induced Pluripotent Stem Cells.

    Science.gov (United States)

    Lee, Ciaran M; Zhu, Haibao; Davis, Timothy H; Deshmukh, Harshahardhan; Bao, Gang

    2017-01-01

    The CRISPR/Cas9 system is a powerful tool for precision genome editing. The ability to accurately modify genomic DNA in situ with single nucleotide precision opens up new possibilities for not only basic research but also biotechnology applications and clinical translation. In this chapter, we outline the procedures for design, screening, and validation of CRISPR/Cas9 systems for targeted modification of coding sequences in the human genome and how to perform genome editing in induced pluripotent stem cells with high efficiency and specificity.

  17. Chapter 6 – Computer-Aided Molecular Design and Property Prediction

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Zhang, L.; Kalakul, Sawitree

    2017-01-01

    for the initial stages of the design/development process. Therefore, computer-aided molecular design and property prediction techniques are two topics that play important roles in chemical product design, analysis, and application. In this chapter, an overview of the concepts, methods, and tools related......Today's society needs many chemical-based products for its survival, nutrition, health, transportation, agriculture, and the functioning of processes. Chemical-based products have to be designed/developed in order to meet these needs, while at the same time, they must be innovative and sustainable...... to these two topics are given. In addition, a generic computer-aided framework for the design of molecules, mixtures, and blends is presented. The application of the framework is highlighted for molecular products through two case studies involving the design of refrigerants and surfactants....

  18. Microstructural effects on mechanical properties data for elevated-temperature reactor design

    International Nuclear Information System (INIS)

    Klueh, R.L.; Brinkman, C.R.; Sikka, V.K.

    1977-01-01

    We are presently generating mechanical property design data for types 304 and 316 stainless steels and 2 1/4 Cr-1 Mo-steel. In addition to the determination of design data on single heats of the steel, we are also examining mechanical property data variation. One of the objectives of this work is the acquisition of an understanding of the cause of mechanical properties variations from heat-to-heat. In types 304 and 316 stainless steels, much of the heat-to-heat variation has been explained in terms of variations in carbon and nitrogen concentration and grain size; a relationship was found between these quantities and the ultimate tensile strength. Since it was possible to relate the ultimate tensile strength to the 1000 hr rupture life, the creep-rupture properties could also be related to the variations in chemical composition. The variations in properties for a ferritic steel such as 2 1/4 Cr-1 Mo steel are again chemistry dependent, but here heat treatment is of crucial importance. Even when a single heat treatment is considered, however, slight variations in heat treatment procedures (by different vendors) can lead to distinct differences in properties. To understand the effect of variations in heat treatment on 2 1/4 Cr-1 Mo steel, we made studies on a heat of steel given different 'annealing' treatments. Distinct differences in creep and tensile properties were observed for the different heat treatments. These differences could be explained in terms of the types of precipitation reactions that occur in the material during the heat treatment. Even when identical heat treatments are given to two heats of 2 1/4 Cr-1 Mo steel of similar chemical composition, however, large property differences are sometimes observed. This was noted for fatigue properties, and here some minor element effect on hardenability of the steel may be playing a role

  19. Design Characteristics of Food Frequency Questionnaires in Relation to Their Validity

    NARCIS (Netherlands)

    Molag, M.L.; Vries, de J.H.M.; Ocke, M.C.; Dagnelie, P.C.; Brandt, van den P.A.; Jansen, S.C.; Staveren, van W.A.; Veer, van 't P.

    2007-01-01

    The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups

  20. Design characteristics of food frequency questionnaires in relation to their validity

    NARCIS (Netherlands)

    Molag, M.L.; Vries, J.H.M. de; Ocké, M.C.; Dagnelie, P.C.; Brandt, P.A. van den; Jansen, M.C.J.F.; Staveren, W.A. van; Veer, P. van 't

    2007-01-01

    The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups

  1. Evaluating the Validity of Classroom Observations in the Head Start Designation Renewal System

    Science.gov (United States)

    Mashburn, Andrew J.

    2017-01-01

    Classroom observations are increasingly common in education policies as a means to assess the quality of teachers and/or education programs for purposes of making high-stakes decisions. This article considers one policy, the Head Start Designation Renewal System (DRS), which involves classroom observations to assess the quality of Head Start…

  2. The Conceptions about Teamwork Questionnaire: Design, Reliability and Validity with Secondary Students

    Science.gov (United States)

    Martinez-Fernandez, J. Reinaldo; Corcelles, Mariona; Cerrato-Lara, Maria

    2011-01-01

    In this study, we present the conceptions about teamwork questionnaire designed to evaluate the conceptions that secondary students have about teamwork. Participants were 309 students aged 15-16 from eight secondary schools, seven from Barcelona and one from Girona (Spain). The original 27-item questionnaire was reduced according to expert…

  3. Psychometric properties of the Revised Fibromyalgia Impact Questionnaire (FIQR – a contribution to the Portuguese validation of the scale

    Directory of Open Access Journals (Sweden)

    Carlos Costa

    2016-07-01

    Full Text Available Background: Fibromyalgia (FM remains a relatively misunderstood and clinically challenging condition that impact significantly in the individual´s life, impairing global functioning and diminishing quality of life. Management is complex and frequently unsatisfactory, requiring personal tailoring and adaptation of interventions according to the fluctuations of the disease manifestations and their response to therapy. The use of comprehensive and quantified assessment tools constitutes, therefore, an essential component of the management of patients with FM. The Revised Fibromyalgia Impact Questionnaire (FIQR is currently one of the most used and well validated instruments to assess functional (incapacity and global impact of FM and associated symptoms. Objectives: To translate to Portuguese the FIQR and to study its psychometric properties. Material and Methods: The total sample comprised 103 women with fibromyalgia, defined according to the established criteria for FM. A self-report battery composed by the Revised Fibromyalgia Impact Questionnaire (FIQR, the Portuguese version of Beck Depression Inventory-II (BDI-II and the Profile of Mood States (PoMS was administered. The FIQR was re-administered to twenty-four participants, six weeks after the first evaluation. Internal reliability was assessed through Cronbach’s alpha, corrected item-total score correlations and alpha if item deleted. Spearman and Pearson correlations along with repeated measures tests were computed to assess the temporal stability of the scale. Convergent and divergent validity were assessed via Spearman and Pearson correlations. Results: The FIQR demonstrated a good to very good internal consistency (from α = 0.87 to α = 0.94. All items correlated to a good degree (above 0.30 to the total score and contributed significantly to the overall reliability. Moreover, FIQR presented a good temporal stability (from r = .617 to r = .886, p ≤ .001 and favorable convergent and

  4. Know your fibers : process and properties, or, a material science approach to designing pulp molded products

    Science.gov (United States)

    John F. Hunt

    1998-01-01

    The following results are preliminary, but show some basic information that will be used in an attempt to model pulp molded structures so that by measuring several basic fundamental properties of a fiber furnish and specifying process conditions, a molded structure could be designed for a particular performance need.

  5. Selection of Prediction Methods for Thermophysical Properties for Process Modeling and Product Design of Biodiesel Manufacturing

    DEFF Research Database (Denmark)

    Su, Yung-Chieh; Liu, Y. A.; Díaz Tovar, Carlos Axel

    2011-01-01

    To optimize biodiesel manufacturing, many reported studies have built simulation models to quantify the relationship between operating conditions and process performance. For mass and energy balance simulations, it is essential to know the four fundamental thermophysical properties of the feed oil...... prediction methods on our group Web site (www.design.che.vt.edu) for the reader to download without charge....

  6. Design and properties of 3D scaffolds for bone tissue engineering.

    Science.gov (United States)

    Gómez, S; Vlad, M D; López, J; Fernández, E

    2016-09-15

    In this study, the Voronoi tessellation method has been used to design novel bone like three dimension (3D) porous scaffolds. The Voronoi method has been processed with computer design software to obtain 3D virtual isotropic porous interconnected models, exactly matching the main histomorphometric indices of trabecular bone (trabecular thickness, trabecular separation, trabecular number, bone volume to total volume ratio, bone surface to bone volume ratio, etc.). These bone like models have been further computed for mechanical (elastic modulus) and fluid mass transport (permeability) properties. The results show that the final properties of the scaffolds can be controlled during their microstructure and histomorphometric initial design stage. It is also shown that final properties can be tuned during the design stage to exactly match those of trabecular natural bone. Moreover, identical total porosity models can be designed with quite different specific bone surface area and thus, this specific microstructural feature can be used to favour cell adhesion, migration and, ultimately, new bone apposition (i.e. osteoconduction). Once the virtual models are fully characterized and optimized, these can be easily 3D printed by additive manufacturing and/or stereolitography technologies. The significance of this article goes far beyond the specific objectives on which it is focussed. In fact, it shows, in a guided way, the entire novel process that can be followed to design graded porous implants, whatever its external shape and geometry, but internally tuned to the exact histomorphometric indices needed to match natural human tissues microstructures and, consequently, their mechanical and fluid properties, among others. The significance is even more relevant nowadays thanks to the available new computing and design software that is easily linked to the 3D printing new technologies. It is this transversality, at the frontier of different disciplines, the main characteristic

  7. Systematic Design Method and Experimental Validation of a 2-DOF Compliant Parallel Mechanism with Excellent Input and Output Decoupling Performances

    Directory of Open Access Journals (Sweden)

    Yao Jiang

    2017-06-01

    Full Text Available The output and input coupling characteristics of the compliant parallel mechanism (CPM bring difficulty in the motion control and challenge its high performance and operational safety. This paper presents a systematic design method for a 2-degrees-of-freedom (DOFs CPM with excellent decoupling performance. A symmetric kinematic structure