Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions

DEFF Research Database (Denmark)

Reed, W.; Bryne, M.; Clausen, Henrik

1994-01-01

positive for T antigen, 82% for s-T antigen, 66% for Tn antigen and 22% for s-Tn antigen. The staining pattern was nearly identical for carcinomas with and without lymph node metastases. In conclusion, immunostaining for simple mucins does not permit a clear distinction between benign and malignant breast...

Demonstration of criticality safety for the modified TN-REG and TN-BRP transport/storage casks

International Nuclear Information System (INIS)

Parks, C.V.; Fox, P.B.

1989-01-01

An inability to model the structural performance of borated steel baskets under accident conditions forced the specially designed TN-BRP and TN-REG casks to be modified for half-loaded shipments. This paper discusses the approach used to demonstrate that the half-loaded casks would remain safely subcritical even if no credit were taken for the borated basket. Normal and accident configurations were analyzed with the KENO V.a code. The strategy conceived and the analyses performed to demonstrate an acceptable margin of safety are discussed. 5 refs., 3 figs., 2 tabs

Investigating the Nuclear Activity of Barred Spiral Galaxies: The Case of NGC 1672

Science.gov (United States)

Jenkins, L. P.; Brandt, W. N.; Colbert, E. J. M.; Koribalski, B.; Kuntz, K. D.; Levan, A. J.; Ojha, R.; Roberts, T. P.; Ward, M. J.; Zezas, A.

2011-06-01

We have performed an X-ray study of the nearby barred spiral galaxy NGC 1672, primarily to ascertain the effect of the bar on its nuclear activity. We use both Chandra and XMM-Newton observations to investigate its X-ray properties, together with supporting high-resolution optical imaging data from the Hubble Space Telescope (HST), infrared imaging from the Spitzer Space Telescope, and Australia Telescope Compact Array ground-based radio data. We detect 28 X-ray sources within the D 25 area of the galaxy; many are spatially correlated with star formation in the bar and spiral arms, and two are identified as background galaxies in the HST images. Nine of the X-ray sources are ultraluminous X-ray sources, with the three brightest (LX > 5 × 1039 erg s-1) located at the ends of the bar. With the spatial resolution of Chandra, we are able to show for the first time that NGC 1672 possesses a hard (Γ ~ 1.5) nuclear X-ray source with a 2-10 keV luminosity of 4 × 1038 erg s-1. This is surrounded by an X-ray-bright circumnuclear star-forming ring, comprised of point sources and hot gas, which dominates the 2-10 keV emission in the central region of the galaxy. The spatially resolved multiwavelength photometry indicates that the nuclear source is a low-luminosity active galactic nucleus (LLAGN), but with star formation activity close to the central black hole. A high-resolution multiwavelength survey is required to fully assess the impact of both large-scale bars and smaller-scale phenomena such as nuclear bars, rings, and nuclear spirals on the fueling of LLAGN.

Influence of local regulations on TN dual purpose BWR casks

International Nuclear Information System (INIS)

Samson, P.; Neider, T.

1999-01-01

Transnucleaire (Paris, France) and Transnuclear, Inc. (Hawthorne, New York, United Sates) have both developed Pressurized Water Reactor (PWR) spent fuel casks for storage and transport purposes. The products are supplied in Europe by Transnucleaire and in the United States by Transnuclear, Inc. Now the TN Group is working on a design for Boiling Water Reactor (BWR) spent fuel assemblies: the TN 52 L cask is designed for transport and storage is Switzerland, the TN 68 cask is designed for transport and storage in the United States. For storage purpose, national regulatory requirements have to be met: each country has specific demands and criteria. As a consequence, differences between the TN 52 L design and the TN 68 design for rather similar contents appear in several fields: the design work, the licensing process, the manufacturing and the operational life. (author)

TRANSIT--A Software Tool for Himar1 TnSeq Analysis.

Directory of Open Access Journals (Sweden)

Michael A DeJesus

2015-10-01

Full Text Available TnSeq has become a popular technique for determining the essentiality of genomic regions in bacterial organisms. Several methods have been developed to analyze the wealth of data that has been obtained through TnSeq experiments. We developed a tool for analyzing Himar1 TnSeq data called TRANSIT. TRANSIT provides a graphical interface to three different statistical methods for analyzing TnSeq data. These methods cover a variety of approaches capable of identifying essential genes in individual datasets as well as comparative analysis between conditions. We demonstrate the utility of this software by analyzing TnSeq datasets of M. tuberculosis grown on glycerol and cholesterol. We show that TRANSIT can be used to discover genes which have been previously implicated for growth on these carbon sources. TRANSIT is written in Python, and thus can be run on Windows, OSX and Linux platforms. The source code is distributed under the GNU GPL v3 license and can be obtained from the following GitHub repository: https://github.com/mad-lab/transit.

Prediction of Microcystis Blooms Based on TN:TP Ratio and Lake Origin

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Yoshimasa Amano

2008-01-01

Full Text Available We evaluated the relationship between TN:TP ratio and Microcystis growth via a database that includes worldwide lakes based on four types of lake origin (dammed, tectonic, coastal, and volcanic lakes. We used microcosm and mesocosm for the nutrient elution tests with lake water and four kinds of sediment (nontreated, MgO sprinkling treated, dissolved air flotation [DAF] treated, and combined treated sediment in order to control TN:TP ratio and to suppress Microcystis growth. Microcystis growth was related to TN:TP ratio, with the maximum value at an optimum TN:TP ratio and the minimum values when the TN:TP ratios reached to 0 or ∞. The kurtosis of the distribution curve varied with the type of lake origin; the lowest kurtosis was found in dammed lakes, while the highest was found in volcanic lakes. The lake trophic state could affect the change in the kurtosis, providing much lower kurtosis at eutrophic lakes (dammed lakes than that at oligotrophic lakes (volcanic lakes. The relationship between TN:TP ratio and Microcystis growth could be explained by the nutrient elution tests under controlled TN:TP ratios through the various sediment treatments. A significant suppression of Microcystis growth of 70% could be achieved when the TN:TP ratios exceeded 21. Lake origin could be regarded as an index including morphological and geographical factors, and controlling the trophic state in lakes. The origin rather than trophic state for lakes could be considered as an important factor of TN:TP influences on Microcystis growth.

EC-fans and fan control systems; EC-ventilatoren en ventilatorregelsystemen

Energy Technology Data Exchange (ETDEWEB)

Havenaar, D.

2011-07-15

Saving of energy can be achieved by the design and application of energy efficient components such as EC-fans (EC stands for Electronically Commutated technology), which are used in different types of cooling-refrigeration and air conditioning systems. In this article attention is paid to two products of Ziehl-Abigg: the Icontrol and the Fcontrol frequency converters. [Dutch] Het beperken van het energiegebruik en het verminderen van de uitstoot van het broeikasgas CO2 is voor de sector een belangrijke opgave. Door het ontwerpen en toepassen van energie-efficiente componenten zoals EC-ventilatoren (EC staat voor Electronically Commutated technologie) in allerlei koel-, vries- en luchtbehandelingsinstallaties kan veel bespaard worden in het energiegebruik. In dit artikel wordt aandacht besteed aan 2 producten van Ziehl-Abigg: de Icontrol en de Fcontrol frequentie omvormers.

An insight into the thermodynamic characteristics of human thrombopoietin complexation with TN1 antibody

Science.gov (United States)

Shibazaki, Chie; Adachi, Motoyasu; Honjo, Eijiro; Tamada, Taro; Maeda, Yoshitake; Tahara, Tomoyuki; Kato, Takashi; Miyazaki, Hiroshi; Blaber, Michael; Kuroki, Ryota

2016-01-01

Abstract Human thrombopoietin (hTPO) primarily stimulates megakaryocytopoiesis and platelet production and is neutralized by the mouse TN1 antibody. The thermodynamic characteristics of TN1 antibody–hTPO complexation were analyzed by isothermal titration calorimetry (ITC) using an antigen‐binding fragment (Fab) derived from the TN1 antibody (TN1‐Fab). To clarify the mechanism by which hTPO is recognized by TN1‐Fab the conformation of free TN1‐Fab was determined to a resolution of 2.0 Å using X‐ray crystallography and compared with the hTPO‐bound form of TN1‐Fab determined by a previous study. This structural comparison revealed that the conformation of TN1‐Fab does not substantially change after hTPO binding and a set of 15 water molecules is released from the antigen‐binding site (paratope) of TN1‐Fab upon hTPO complexation. Interestingly, the heat capacity change (ΔCp) measured by ITC (−1.52 ± 0.05 kJ mol−1 K−1) differed significantly from calculations based upon the X‐ray structure data of the hTPO‐bound and unbound forms of TN1‐Fab (−1.02 ∼ 0.25 kJ mol−1 K−1) suggesting that hTPO undergoes an induced‐fit conformational change combined with significant desolvation upon TN1‐Fab binding. The results shed light on the structural biology associated with neutralizing antibody recognition. PMID:27419667

Establishment of colloid gold immunity chromatography assay for cardiac troponin I (cTnI)

International Nuclear Information System (INIS)

Wang Dezhi; Chen Jiying; Qin Lili; Zhao Baojian; Zhang Chunming

2006-01-01

Objective: To establish the colloid gold Immunity chromatography assay for cardiac troponin I. Methods: To purify cTnI from human cardiac muscle and immunize rabbit with it. cTnI antibody of rabbit anti-human cardiac muscle has been prepared and colloid gold immunity chromatography assay was established by using immunity chromatography technology. Results: Anti-serum titles of cTnI were 1:100000, Ka=2.38 x 10 9 L/mol; Methodological index: Sensitivity: 5 ng/ml; Specificity: cTnI is no cross-reaction with cTnT, cTnC and CK-MB. conclusion: The assay is highly specific, quick and simple. It can be widely used for the early diagnosis of AMI and scientific research. (authors)

ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues

DEFF Research Database (Denmark)

Marcos, Nuno T; Bennett, Eric P; Gomes, Joana

2011-01-01

Sialyl-Tn is a simple mucin-type carbohydrate antigen aberrantly expressed in gastrointestinal adenocarcinomas and in the precursor lesion intestinal metaplasia. Sialyl-Tn tumour expression is an independent indicator of poor prognosis. We have previously shown in vitro that ST6GalNAc-I and ST6GalNAc......-II sialyltransferases can synthesize sialyl-Tn. The aim of the present study was to establish whether ST6GalNAc-I is the major enzyme responsible for the expression of sialyl-Tn. We used a model of CHO-ldlD cells producing only MUC1-Tn glycoform and showed that ST6GalNAc-I is the key-enzyme leading to sialyl......-Tn biosynthesis. We developed novel monoclonal antibodies specific for ST6GalNAc-I and evaluated its expression in gastrointestinal tissues. ST6GalNAc-I was detected in normal colon mucosa co-localized with O-acetylated sialyl-Tn. Expression was largely unaltered in colorectal adenocarcinomas. In contrast, we...

Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

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Hussam E Salhi

2016-12-01

Full Text Available Troponin I (TnI is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit an expected or unexpected functional integration, whereby the function of two phosphorylations are different than that predicted from the combined function of each individual phosphorylation alone. We have shown that TnI Ser-23/24 and Ser-150 phosphorylation exhibit functional integration and are simultaneously increased in response to cardiac stress. In the current study, we investigated the functional integration of TnI Ser-23/24 and Ser-150 to alter cardiac contraction. We hypothesized that Ser-23/24 and Ser-150 phosphorylation each utilize distinct molecular mechanisms to alter the TnI binding affinity within the thin filament. Mathematical modeling predicts that Ser-23/24 and Ser-150 phosphorylation affect different TnI affinities within the thin filament to distinctly alter the Ca2+-binding properties of troponin. Protein binding experiments validate this assertion by demonstrating pseudo-phosphorylated Ser-150 decreases the affinity of isolated TnI for actin, whereas Ser-23/24 pseudo-phosphorylation is not different from unphosphorylated. Thus, our data supports that TnI Ser-23/24 affects TnI-TnC binding, while Ser-150 phosphorylation alters TnI-actin binding. By measuring force development in troponin-exchanged skinned myocytes, we demonstrate that the Ca2+ sensitivity of force is directly related to the amount of phosphate present on TnI. Furthermore, we demonstrate that Ser-150 pseudo-phosphorylation blunts Ser-23/24-mediated decreased Ca2+-sensitive force development whether on the same or different TnI molecule. Therefore, TnI phosphorylations can integrate across troponins along the myofilament. These data demonstrate

Antibiotic and antiseptic resistance genes are linked on a novel mobile genetic element: Tn6087

Science.gov (United States)

Ciric, Lena; Mullany, Peter; Roberts, Adam P.

2011-01-01

Objectives Tn916-like elements are one of the most common types of integrative and conjugative element (ICE). In this study we aimed to determine whether novel accessory genes, i.e. genes whose products are not involved in mobility or regulation, were present on a Tn916-like element (Tn6087) isolated from Streptococcus oralis from the human oral cavity. Methods A minocycline-resistant isolate was analysed using restriction fragment length polymorphism (RFLP) analysis on amplicons derived from Tn916 and DNA sequencing to determine whether there were genetic differences in Tn6087 compared with Tn916. Mutational analysis was used to determine whether the novel accessory gene found was responsible for an observed extra phenotype. Results A novel Tn916-like element, Tn6087, is described that encodes both antibiotic and antiseptic resistance. The antiseptic resistance protein is encoded by a novel small multidrug resistance gene, designated qrg, that was shown to encode resistance to cetyltrimethylammonium bromide (CTAB), also known as cetrimide bromide. Conclusions This is the first Tn916-like element described that confers both antibiotic and antiseptic resistance, suggesting that selection of either antibiotic or antiseptic resistance will also select for the other and further highlights the need for prudent use of both types of compound. PMID:21816764

Tennessee Comptroller of the Treasury (TN COMP)

Data.gov (United States)

Social Security Administration — The Tennessee Comptroller of the Treasury (TN COMP) uses SSA's assistance in administering the Tennessee Property Tax Rebate Program. SSA provides assistance through...

Rapid procedure to calibrate EC-10 and EC-20 capacitance sensors ...

African Journals Online (AJOL)

A rapid calibration procedure for EC-10 and EC-20 sensors is introduced to promote the commercial use of these sensors for hydroponic irrigation management in coir. The method is comprised of taking one sensor reading, by a sensor installed under hydroponic crop production conditions, and one gravimetric sample, ...

A New Generalizable Test for Detection of Mutations Affecting Tn10 Transposition

OpenAIRE

Huisman, Olivier; Kleckner, Nancy

1987-01-01

We describe here a new rapid screen that allows easy detection of transposon or host mutations that affect Tn10 transposition in Escherichia coli. This test involves a new Tn10 derivative called the "mini-lacZ-kanR fusion hopper" or mini-Tn10-LK for short. This element does not direct expression of β-galactosidase when present at its original starting location on a suitably engineered plasmid or phage genome because it lacks appropriate transcription and translation start signals. However, t...

Determination of primary combustion source organic carbon-to-elemental carbon (OC / EC ratio using ambient OC and EC measurements: secondary OC-EC correlation minimization method

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C. Wu

2016-05-01

Full Text Available Elemental carbon (EC has been widely used as a tracer to track the portion of co-emitted primary organic carbon (OC and, by extension, to estimate secondary OC (SOC from ambient observations of EC and OC. Key to this EC tracer method is to determine an appropriate OC / EC ratio that represents primary combustion emission sources (i.e., (OC / ECpri at the observation site. The conventional approaches include regressing OC against EC within a fixed percentile of the lowest (OC / EC ratio data (usually 5–20 % or relying on a subset of sampling days with low photochemical activity and dominated by local emissions. The drawback of these approaches is rooted in its empirical nature, i.e., a lack of clear quantitative criteria in the selection of data subsets for the (OC / ECpri determination. We examine here a method that derives (OC / ECpri through calculating a hypothetical set of (OC / ECpri and SOC followed by seeking the minimum of the coefficient of correlation (R2 between SOC and EC. The hypothetical (OC / ECpri that generates the minimum R2(SOC,EC then represents the actual (OC / ECpri ratio if variations of EC and SOC are independent and (OC / ECpri is relatively constant in the study period. This Minimum R Squared (MRS method has a clear quantitative criterion for the (OC / ECpri calculation. This work uses numerically simulated data to evaluate the accuracy of SOC estimation by the MRS method and to compare with two commonly used methods: minimum OC / EC (OC / ECmin and OC / EC percentile (OC / EC10 %. Log-normally distributed EC and OC concentrations with known proportion of SOC are numerically produced through a pseudorandom number generator. Three scenarios are considered, including a single primary source, two independent primary sources, and two correlated primary sources. The MRS method consistently yields the most accurate SOC estimation. Unbiased SOC estimation by OC�

Variation on a theme; an overview of the Tn916 / Tn1545 family of mobile genetic elements in the oral and nasopharyngeal streptococci.

Directory of Open Access Journals (Sweden)

Francesco eSantoro

2014-10-01

Full Text Available The oral and nasopharyngeal streptococci are a major part of the normal microbiota in humans. Most human associated streptococci are considered commensals however a small number of them are pathogenic, causing a wide range of diseases including oral infections such as dental caries and periodontitis and diseases at other body sites including sinusitis and endocarditis, and in the case of Streptococcus pneumoniae, meningitis. Both phenotypic and sequence based studies have shown that the human associated streptococci from the mouth and nasopharynx harbour a large number of antibiotic resistance genes and these are often located on mobile genetic elements known as conjugative transposons or integrative and conjugative elements of the Tn916 / Tn1545 family. These mobile genetic elements are responsible for the spread of the resistance genes between streptococci and also between streptococci and other bacteria. In this review we describe the resistances conferred by, and the genetic variations between the many different Tn916-like elements found in recent studies of oral and nasopharyngeal streptococci and show that Tn916-like elements are important mediators of antibiotic resistance genes within this genus. We will also discuss the role of the oral environment and how this is conducive to the transfer of these elements and discuss the contribution of both transformation and conjugation on the transfer and evolution of these elements in different streptococci.

ETIOLOGY CLASSIFICATION AND TREATMENT NEEDS (TN FOR ORAL MALODOR

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Anton Raharjo

2015-08-01

Full Text Available Background: Oral malodor, a generic descriptor term for foul smells emanating from the mouth can be classified as either pathological or physiological halitosis. Some problems are often confounded by the clinician's mismanagement. Objective: This paper reviews the etiology of classification and determination of treatment needs (TN for oral malodor. Literature review and discussion: In the majority of cases the problem has been shown to originate in the oral cavity. Although oral malodor cases are often related to physiological aspects, sometimes they can be related to extra oral sources and psychological aspects. Classification methods of oral malodor with corresponding treatment needs (TN have already been established. Although PTC & tongue brushing and appropriate mouthrinses are both important and basic treatment measures for halitosis, other dental treatments are sometimes required. Conclusion: Accurate screening and diagnosis of halitosis followed by appropriate TN may give better results and consequently reduce the risk of mismanagement.

In-site interaction evaluation of Tn density by inhibition/competition assays

Energy Technology Data Exchange (ETDEWEB)

Robles, Ana [Radiopharmacy Department, Nuclear Research Center, Faculty of Sciences, University of the Republic, Montevideo (Uruguay)], E-mail: anamar@cin.edu.uy; Medeiros, Andrea [Biochemistry Department, Faculty of Medicine, University of the Republic, Montevideo (Uruguay); Berois, Nora [Laboratory of Glycobiology and Tumor Immunology, Pasteur Institute of Montevideo (Uruguay); Balter, Henia S. [Radiopharmacy Department, Nuclear Research Center, Faculty of Sciences, University of the Republic, Montevideo (Uruguay); Pauwels, Ernest K. [University Medical Center Leiden, Department of Radiology, Leiden (Netherlands); Osinaga, Eduardo [Laboratory of Glycobiology and Tumor Immunology, Pasteur Institute of Montevideo (Uruguay); Department of Immunobiology, Faculty of Medicine, University of the Republic, Montevideo (Uruguay)

2010-05-15

The tumor-associated structure N-acetyl-galactosamine-O-Ser/Thr (Tn antigen), which is overexpressed in various tumor cell types, notably of the breast, ovary and colon, is an interesting determinant that is useful for cancer diagnosis and follow-up. The aim of this research was to study different assay strategies in order to determine the most sensitive system for further application in epitope characterization and binding assessment. The tetrameric isolectin obtained from Vicia villosa seeds (VVLB{sub 4}) shows high affinity for the tumor-associated structure. A monoclonal antibody against VVLB{sub 4}, MabVV{sub 34}, was generated, and the interaction between MabVV{sub 34} and VVLB{sub 4} was studied by means of binding and inhibition assays. Several synthetic peptides (10 amino acid sequences) designed from the amino acid sequence of VVLB{sub 4} and obtained from trypsin digestion were tested to determine which amino acids were involved in the interaction between MabVV{sub 34} and VVLB{sub 4}. The further unraveling of this epitope was investigated by inhibition using designed synthetic peptides as well as mixtures mimicking variable density effect. Under the experimental circumstances, MabVV{sub 34} was able to inhibit the binding of VVLB{sub 4} to Tn. Two of the four peptide sequences assayed showed better inhibition properties. Finally, mixtures containing these selected sequences allowed the evaluation of binding and inhibition as a function of Tn density. We conclude that the present study facilitates the further development of a specific Tn marker and may contribute to the development of Tn-like radiolabelled peptides or Tn-specific radiolabelled fragments providing a highly selective tool for cancer diagnosis and treatment. This strategy may contribute to characterize the new generation of radiopharmaceuticals for diagnosis and therapy based on biomolecules like antibodies, fragments or peptides, whose application is directly guided by their specific

Some reproductive performances of Thai native (TN and 50% TN x Anglo-Nubian crossbred does with different levels of concentrate supplementation

Directory of Open Access Journals (Sweden)

Choldumrongkul, S.

2007-05-01

Full Text Available A 2 x 2 x 2 factorial in completely randomized design was conducted to determine the effect of genotype of does (Thai native (TN or 50% Anglo-Nubian (AN crossbred, levels of concentrate supplementation(1 % body weight or ad libitum and body condition of does (poor or good on oestrus incidence, kidding rate and multiple birth rate of does. Does rotationally grazed on Paspalum plicatulum pasture for 4 weeks andwere supplemented with concentrate. The experiment was divided into 4 periods: 1 does run with a teaser for 105 days before mating to determine an oestrus incidence 2 does joined with bucks of the same genotypefor 45 days 3 does run with a teaser for 150 days during pregnancy and 4 does run with a teaser 90 days post-partum. Genotype, levels of concentrate supplementation and body condition of does did not significantlyaffect (P>0.05 kidding rate or multiple birth rate and average kidding rate and multiple birth rate of the does was 83.8 and 82.3%, respectively. Birth weight of kids from TN does was significantly lower (P<0.01 than that from 50% TN x AN crossbred does (1.9 and 2.5 kg, respectively. Number of days of the first oestrus incidence in post-partum period for TN does was significantly (P<0.01 less than that of 50% ANcrossbred does (59.1 days and 75.0 days, respectively. Number of days of the first oestrus incidence in postpartum for does supplemented with concentrate ad libitum was significantly (P<0.01 lower than that ofdoes supplemented with 1% BW of concentrate (60.5 and 73.6 days, respectively.

ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues

DEFF Research Database (Denmark)

Marcos, Nuno T; Bennett, Eric Paul; Gomes, Joana

2011-01-01

-Tn biosynthesis. We developed novel monoclonal antibodies specific for ST6GalNAc-I and evaluated its expression in gastrointestinal tissues. ST6GalNAc-I was detected in normal colon mucosa co-localized with O-acetylated sialyl-Tn. Expression was largely unaltered in colorectal adenocarcinomas. In contrast, we......NAc-I as the major enzyme controlling the expression of cancer-associated sialyl-Tn antigen in gastrointestinal tissues....

cTnT can be a useful marker for early detection of anthracycline cardiotoxicity.

Science.gov (United States)

Kilickap, S; Barista, I; Akgul, E; Aytemir, K; Aksoyek, S; Aksoy, S; Celik, I; Kes, S; Tekuzman, G

2005-05-01

The level of serum cardiac troponin-T (cTnT) increases with myocardial damage. We sought to assess whether cTnT level could be a useful marker for the early detection of anthracycline cardiotoxicity. Forty-one patients who had been scheduled to receive anthracycline-containing combination chemotherapy were included in the study. Serum cTnT levels were measured before (baseline) and after the first cycle of chemotherapy, and again, after the last cycle of chemotherapy. In all patients, the left ventricular ejection fraction (LVEF), fractional shortening (FS), early peak flow/atrial flow velocity (E/A) ratio, and the isovolemic relaxation time (IRT) were measured echocardiographically, both before and after the completion of chemotherapy. LVEF and FS did not change in any patients. In 21 patients (49%), the E/A ratio decreased after therapy as compared to the pre-treatment values. The decrease in E/A ratio was more prominent in patients who were older than the mean age of our study group, which was 44 years. The post-treatment IRT was prolonged compared with the pretreatment IRT (94.0 +/- 2.0 versus 85.6 +/- 10.5 ms, respectively). cTnT levels after completion of therapy were elevated in 14 (34%) patients, and exceeded the upper limit of the normal range (>0.1 ng/ml) in only one patient. cTnT levels measured after completion of therapy were significantly higher, compared with those measured at baseline and after the first cycle of therapy. In the younger age group (< or =44 years old), there was a two-fold decrease in the E/A ratio in those patients whose cTnT levels increased during the therapy, when compared with those whose cTnT levels did not change (21% versus 43%, respectively). Increased serum cTnT level can be detected in the early stages of anthracycline therapy and it is associated with diastolic dysfunction of the left ventricle. Therefore, serum cTnT level could be a useful measure for early detection of anthracycline-induced cardiotoxicity.

Formulation and in vitro evaluation of theophylline matrix tablets prepared by direct compression: Effect of polymer blends

Science.gov (United States)

El-Bagory, Ibrahim; Barakat, Nahla; Ibrahim, Mohamed A.; El-Enazi, Fouza

2011-01-01

The deformation mechanism of pharmaceutical powders, used in formulating directly compressed matrix tablets, affects the characteristics of the formed tablets. Three polymers of different deformation mechanisms were tested for their impact on theophylline directly compressed tablets namely Kollidon SR (KL SR, plastic deformation), Ethylcellulose (EC, elastic deformation) and Carnauba wax (CW, brittle deformation) at different compression forces. However, tablets based mainly on KL SR, the plastically deformed polymer (TN1) exhibited the highest hardness values compared to the other formulae which are based on either blends of KL SR with CW, the very brittle deformed polymer. The upper detected force for TN formulae and the lower punch force were found to dependent mainly on the powder deformation. This difference is attributed to the work done during the compression phase as well as the work lost during the decompression phase. Furthermore, the release profiles of TN from formulae TN2 and TN4 that are based on the composition (2KL SR:1EC) and (1KL SR:2EC), respectively, were consistent with different deformation mechanisms of KL SR and EC and on the physicochemical properties like the water absorptive capacity of EC. Upon increasing the weight ratio of KL SR (TN2), the release rate was greatly retarded (39.4%, 37.1%, 35.0% and 33.6% released after 8 h at 5, 10, 15 and 20 kN. PMID:24115902

Application of ECS to a hybrid automobile; `ECS` no hybrid jidosha eno tekiyo

Energy Technology Data Exchange (ETDEWEB)

Shimizu, M.; Okamura, T.

1997-01-30

This paper describes a simulation for a case when an energy capacitor system (ECS) is mounted in a hybrid electric vehicle in place of secondary batteries. The ECS is electric power storage equipment consisted of capacitors and electronic circuits, and capable of quick charge and discharge at high efficiency. Its energy density per unit weight is about the same as lead-acid batteries, but its output density is greater than any type of batteries. Being free of deterioration due to charge and discharge, its cycle life is almost limitless. In order to suppress heat generation, a switching converter is used to control the output to about 300W. However, internal resistance of an ECS is smaller than in an equivalent secondary battery, and internal loss and heat generation stay as low as 1/5 to 1/10. Discussions have been given on cases of using the ECS in small passenger cars, small buses/trucks, and large buses. Since the ECS can use the stored power to about 94% of the capacity, and its cycle life is sufficiently long, it can operate with charge capacity as small as 1/4 of a lead-acid battery. The weight can also be reduced largely. Regenerative power storage efficiency is high, fuel consumption can be improved, heat generation is less, and no forced cooling is required. 9 refs., 4 figs., 1 tab.

Induction of transposon TN1 translocation under the action of different mutagens

International Nuclear Information System (INIS)

Kubanejshvili, M.G.; Smirnov, S.P.; Tarasov, V.A.

1983-01-01

Migration of ampicillin transposon Tn1 under normal conditions in Escherichia coli cells proceeds with low frequency (10 -4 transpositions for cell). The low transposition frequency is conditioned by the transposition repression, realized by the gene-repressor in transposon structure and, probably, by other regulating genes of the bacterium-host. E. coli cell treatment by physical and chemical mutagens resulted in induction of translocation of ampicillin transposon Tn1 from plasmid RP4 into other replicons. Mitomycin C and ultraviolet radiation produced stronger inducing effect as compared to nitroso-guanidine (NG). The effect of the given mutagens on transposition Tn1 correlated with their activating capacity with respect to inducible SOS-functions of E coli. The mutation of rec A didn't influence on spontaneous Tn1 transposition, but blocked completely the induction of transposition process under mutagen effect. The relationship of inducible transposition with SOS-functions in E. coli cells, controlled by recA and lexA genes, as well as the possible role of the process in genetic microorganism variability are discussed in the paper

Comblike dendrimers containing Tn antigen modulate natural killing and induce the production of Tn specific antibodies

Czech Academy of Sciences Publication Activity Database

Vepřek, Pavel; Hajdúch, M.; Džubák, P.; Kulík, R.; Poláková, J.; Bezouška, Karel

2006-01-01

Roč. 49, č. 21 (2006), s. 6400-6407 ISSN 0022-2623 R&D Projects: GA AV ČR IAA4020213; GA AV ČR IAA5020403; GA ČR GA304/06/1691 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50200510 Keywords : Tn antigen * glycodendrimer * NKP-P1 Subject RIV: CE - Biochemistry Impact factor: 5.115, year: 2006

Pharmaceutical significance of Leuconostoc mesenteroides KS-TN11 isolated from Nile Tilapia, Oreochromis niloticus

Directory of Open Access Journals (Sweden)

Bilal Ahmad Paray

2018-05-01

Full Text Available Aquatic animals are known for their myriad of beneficial bacteria with diverse biologically active compounds. The current study was aimed to isolate and characterize potentially beneficial lactic acid bacteria from Nile Tilapia and evaluate their pharmaceutical applications. The fish samples were dissected and stomach, intestine, and gills were collected and serially diluted for the isolation of lactic acid bacteria (LAB on BCP agar media. Identification of isolate was carried by biochemical and molecular characterization using API kit and 16S rRNA gene sequencing analysis, respectively. Further, KS-TN11 was assessed for α-glucosidase inhibitory potential using the chromogenic method. A lactic acid bacterium KS-TN11 was isolated from the stomach of Nile Tilapia and identified as Leuconostoc mesenteroides. Effect of KS-TN11 on lipid accumulation in adipocytes was done by using Oil Red O staining. The isolate showed strong antibacterial activity against a number of pathogenic bacteria in vitro. In addition, L. mesenteroides KS-TN11 KS-TN11 (50 mg/ml and 100 mg/ml tends to inhibit adipogenesis in 3T3-L1 adipocytes and thus may have possible anti-obesity effects. Moreover, L. mesenteroides KS-TN11 exhibited substantial α–glucosidase inhibitory activities by 41.33% at 50 mg/ml and 64% at 100 mg/ml, respectively. The bacterium showed potent antibacterial activity against a number of pathogenic bacteria; in addition to alpha-glucosidase activity, and inhibition of lipid accumulation in 3T3-L1 cell line. These results reinforce KS-TN11 as a novel bacterium with an impending pharmaceutical application. Keywords: Lactic acid bacteria, Antimicrobial, Fish microflora, Anti-diabetic

Runoff load estimation of particulate and dissolved nitrogen in Lake Inba watershed using continuous monitoring data on turbidity and electric conductivity.

Science.gov (United States)

Kim, J; Nagano, Y; Furumai, H

2012-01-01

Easy-to-measure surrogate parameters for water quality indicators are needed for real time monitoring as well as for generating data for model calibration and validation. In this study, a novel linear regression model for estimating total nitrogen (TN) based on two surrogate parameters is proposed based on evaluation of pollutant loads flowing into a eutrophic lake. Based on their runoff characteristics during wet weather, electric conductivity (EC) and turbidity were selected as surrogates for particulate nitrogen (PN) and dissolved nitrogen (DN), respectively. Strong linear relationships were established between PN and turbidity and DN and EC, and both models subsequently combined for estimation of TN. This model was evaluated by comparison of estimated and observed TN runoff loads during rainfall events. This analysis showed that turbidity and EC are viable surrogates for PN and DN, respectively, and that the linear regression model for TN concentration was successful in estimating TN runoff loads during rainfall events and also under dry weather conditions.

Two-stage soil infiltration treatment system for treating ammonium wastewaters of low COD/TN ratios.

Science.gov (United States)

Lei, Zhongfang; Wu, Ting; Zhang, Yi; Liu, Xiang; Wan, Chunli; Lee, Duu-Jong; Tay, Joo-Hwa

2013-01-01

Soil infiltration treatment (SIT) is ineffective to treat ammonium wastewaters of total nitrogen (TN) > 100 mg l(-1). This study applied a novel two-stage SIT process for effective TN removal from wastewaters of TN>100 mg l(-1) and of chemical oxygen demand (COD)/TN ratio of 3.2-8.6. The wastewater was first fed into the soil column (stage 1) at hydraulic loading rate (HLR) of 0.06 m(3) m(-2) d(-1) for COD removal and total phosphorus (TP) immobilization. Then the effluent from stage 1 was fed individually into four soil columns (stage 2) at 0.02 m(3) m(-2) d(-1) of HLR with different proportions of raw wastewater as additional carbon source. Over the one-year field test, balanced nitrification and denitrification in the two-stage SIT revealed excellent TN removal (>90%) from the tested wastewaters. Copyright © 2012 Elsevier Ltd. All rights reserved.

A Tn5051-like mer-containing transposon identified in a heavy metal tolerant strain Achromobacter sp. AO22

Directory of Open Access Journals (Sweden)

Bhave Mrinal

2009-03-01

Full Text Available Abstract Background Achromobacter sp. AO22 (formerly Alcaligenes sp. AO22, a bacterial strain isolated from a lead-contaminated industrial site in Australia, was previously found to be resistant to moderate to high levels of mercury, copper and other heavy metals. However, the nature and location of the genetic basis for mercuric ion resistance in this strain, had not been previously identified. Findings Achromobacter sp. AO22 contains a functional mer operon with all four essential genes (merRTPA and shows >99% DNA sequence identity to that of Tn501. The mer operon was present on a transposon, designated TnAO22, captured by introducing a broad-host-range IncP plasmid into Achromobacter sp. AO22 and subsequently transferring it to E. coli recipients. The transposition frequency of TnAO22 was 10-2 to 10-3 per target plasmid transferred. Analysis of TnAO22 sequence revealed it belonged to the Tn21 subgroup of the Tn3 superfamily of transposons, with the transposition module having >99% identity with Tn5051 of a Pseudomonas putida strain isolated from a water sample in New York. Conclusion TnAO22 is thus a new variant of Tn5051 of the Tn3 superfamily and the transposon and its associated mercury resistance system are among the few such systems reported in a soil bacterium. Achromobacter sp. AO22 can thus be exploited for applications such as in situ mercury bioremediation of contaminated sites, or the mobile unit and mer operon could be mobilized to other bacteria for similar purposes.

76 FR 14855 - Television Broadcasting Services; Nashville, TN

Science.gov (United States)

2011-03-18

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 11-29, RM-11622; DA 11-335] Television Broadcasting Services; Nashville, TN AGENCY: Federal Communications Commission. ACTION: Proposed... 73 Television, Television broadcasting. Federal Communications Commission. Kevin R. Harding...

Anatomy of a reindeer dissected in Copenhagen in 1672 by Niels Stensen as reported by Thomas Bartholin. I. Introduction by Troels Kardel. II. Translation by Paul Maquet

Directory of Open Access Journals (Sweden)

Troels Kardel

2013-03-01

Full Text Available A report by Professor Thomas Bartholin on the dissection of a reindeer performed in 1672 by his former student Niels Stensen as Royal Anatomist in Copenhagen is presented in English translation with biographical introduction and bibliographical notes. The report is most likely the first of its kind being an early contribution to comparative anatomy.

76 FR 33656 - Television Broadcasting Services; Nashville, TN

Science.gov (United States)

2011-06-09

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 [MB Docket No. 11-29; RM-11622, DA 11-949] Television Broadcasting Services; Nashville, TN AGENCY: Federal Communications Commission. ACTION: Final rule... Part 73 Television. Federal Communications Commission. Barbara A. Kreisman, Chief, Video Division...

BEING AN INTERPRETER IN OTTOMAN GALATA: ESTATE AND DEPTS OF A VENETIAN DRAGOMAN (1672 OSMANLI GALATA’SINDA TERCÜMAN OLMAK: BİR VENEDİK TERCÜMANININ TEREKESİ VE BORÇLARI (1672

Directory of Open Access Journals (Sweden)

Metin Ziya KÖSE

2011-09-01

Full Text Available After opening the embassies of European states in the center of the Ottoman Empire, intensive diplomatic relations began between the both sides. Interpreters are played an important role as mediator agents of two different world. Republic of Venice attributed a special importance to interpretership. Also, an interpreter training school was opened. Venetian interpreters who undertook various tasks were in Istanbul a certain period or all of their lives. They obtained interpreting berat from Ottoman rule to have a number of exemptions. Corci Tomazo, one of this interpreters, was died in Istanbul in 1672. His estate was recorded by the court of Galata. In this study, historical information was given about embassies interpreters, firstly. Later, the estate of Corci has been viewed. A more general conclusions have been reached on the basis of the estate of this interpreter. Osmanlı İmparatorluğu’nun merkezinde Avrupalı devletlerin elçilikleri açıldıktan sonra taraflar arasında yoğun bir diplomatik münasebet başlamıştır. Tercümanlar, iki farklı dünyanın aracıları olarak ilişkilerde önemli bir rol oynamışlardır. Venedik Cumhuriyeti, tercümanlığa ayrı bir önem atfetti ve tercüman yetiştiren bir okul dahi açmıştır. Çeşitli görevler üstlenen Venedikli tercümanlar, belli bir süreliğine ya da hayatlarının tamamında İstanbul’da bulundular. Osmanlı yönetiminden tercümanlık beratı alarak bir takım muafiyetler elde ettiler. Bu tercümanlardan biri olan Corci Tomazo, 1672’de İstanbul’da öldüğünde terekesi Galata kadılığı tarafından kayıt altına alınmıştır. Bu çalışmada ilk olarak elçilik tercümanlarına ait tarihsel bilgiler verilmiştir. Daha sonra ise Corci’nin terekesi incelenmiştir. Bir hayli borçlu olduğu görülen bu tercümanın terekesinden yola çıkılarak daha genel sonuçlara ulaşılmıştır.

An Enterobacter plasmid as a new genetic background for the transposon Tn1331

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Alavi MR

2011-11-01

Full Text Available Mohammad R Alavi1,2, Vlado Antonic2, Adrien Ravizee1, Peter J Weina3, Mina Izadjoo1,2, Alexander Stojadinovic21Division of Wound Biology and Translational Research, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, 2Combat Wound Initiative Program, Walter Reed Army Medical Center, Washington DC, 3The Walter Reed Army Institute of Research, Silver Spring, MD, USABackground: Genus Enterobacter includes important opportunistic nosocomial pathogens that could infect complex wounds. The presence of antibiotic resistance genes in these microorganisms represents a challenging clinical problem in the treatment of these wounds. In the authors’ screening of antibiotic-resistant bacteria from complex wounds, an Enterobacter species was isolated that harbors antibiotic-resistant plasmids conferring resistance to Escherichia coli. The aim of this study was to identify the resistance genes carried by one of these plasmids.Methods: The plasmids from the Enterobacter isolate were propagated in E. coli and one of the plasmids, designated as pR23, was sequenced by the Sanger method using fluorescent dye-terminator chemistry on a genetic analyzer. The assembled sequence was annotated by search of the GenBank database.Results: Plasmid pR23 is composed of the transposon Tn1331 and a backbone plasmid that is identical to the plasmid pPIGDM1 from Enterobacter agglomerans. The multidrug-resistance transposon Tn1331, which confers resistance to aminoglycoside and beta lactam antibiotics, has been previously isolated only from Klebsiella. The Enterobacter plasmid pPIGDM1, which carries a ColE1-like origin of replication and has no apparent selective marker, appears to provide a backbone for propagation of Tn1331 in Enterobacter. The recognition sequence of Tn1331 transposase for insertion into pPIGDM1 is the pentanucleotide TATTA, which occurs only once throughout the length of this plasmid.Conclusion: Transposition of Tn1331 into

Role of Myofibril-Inducing RNA in cardiac TnT expression in developing Mexican axolotl

Science.gov (United States)

Sferrazza, Gian-Franco; Zhang, Chi; Jia, Pingping; Lemanski, Sharon L.; Athauda, Gagani; Stassi, Alyssa; Halager, Kristine; Maier, Jennifer A.; Rueda-de-Leon, Elena; Gupta, Amit; Dube, Syamalima; Huang, Xupei; Prentice, Howard M.; Dube, Dipak K.; Lemanski, Larry F.

2007-01-01

The Mexican axolotl, Ambystoma mexicanum, has been a useful animal model to study heart development and cardiac myofibrillogenesis. A naturally-occurring recessive mutant, gene “c”, for cardiac non-function in the Mexican axolotl causes a failure of myofibrillogenesis due to a lack of tropomyosin expression in homozygous mutant (c/c) embryonic hearts.. Myofibril-Inducing RNA (MIR) rescues mutant hearts in vitro by promoting tropomyosin expression and myofibril formation thereafter. We have studied the effect of MIR on the expression of various isoforms of cardiac Troponin-T (cTnT), a component of the thin filament that binds with tropomyosin. Four alternatively spliced cTnT isoforms have been characterized from developing axolotl heart. The expression of various cTnT isoforms in normal, mutant, and mutant hearts corrected with MIR, is evaluated by real-time RT-PCR using isoform specific primer pairs; MIR affects the total transcription as well as the splicing of the cTnT in axolotl heart PMID:17408593

Japanese version transport/storage packaging 'TN24'

International Nuclear Information System (INIS)

Kakunai, H.; Iida, T.; Tsuda, K.; Akamatsu, H.

1993-01-01

Since 1983, Kobe Steel has been engaged jointly with the French company Transnucleaire in the development of 'TN24', a dry-type transport and storage packaging for irradiated fuel elements. This report describes the packaging, which has been adapted for use in domestic power stations using BWRs on the basis of the results of this development. (J.P.N.)

Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays.

LENUS (Irish Health Repository)

Lee, Graham R

2013-09-18

Non-cardiac surgery is associated with major vascular complications and higher incidences of elevated plasma troponin (cTn) concentration. Goal-directed therapy (GDT) is a stroke volume (SV)-guided approach to intravenous (IV) fluid therapy that improves tissue perfusion, oxygenation and reduces post-operative complications. In patients undergoing major gastro-intestinal surgery, we compared high sensitive and contemporary troponin assays and correlated results with patient outcome.

Developmental regulation of ecdysone receptor (EcR and EcR-controlled gene expression during pharate-adult development of honeybees (Apis mellifera.

Directory of Open Access Journals (Sweden)

Tathyana Rachel Palo Mello

2014-12-01

Full Text Available Major developmental transitions in multicellular organisms are driven by steroid hormones. In insects, these, together with juvenile hormone (JH, control development, metamorphosis, reproduction and aging, and are also suggested to play an important role in caste differentiation of social insects. Here, we aimed to determine how EcR transcription and ecdysteroid titers are related during honeybee postembryonic development and what may actually be the role of EcR in caste development of this social insect. In addition, we expected that knocking-down EcR gene expression would give us information on the participation of the respective protein in regulating downstream targets of EcR. We found that in Apis mellifera females, EcR-A is the predominantly expressed variant in postembryonic development, while EcR-B transcript levels are higher in embryos, indicating an early developmental switch in EcR function. During larval and pupal stages, EcR-B expression levels are very low, while EcR-A transcripts are more variable and abundant in workers compared to queens. Strikingly, these transcript levels are opposite to the ecdysteroid titer profile. 20-hydroxyecdysone (20E application experiments revealed that low 20E levels induce EcR expression during development, whereas high ecdysteroid titers seem to be repressive. By means of RNAi-mediated knockdown (KD of both EcR transcript variants we detected the differential expression of 234 poly-A+ transcripts encoding genes such as CYPs, MRJPs and certain hormone response genes (Kr-h1 and ftz-f1. EcR-KD also promoted the differential expression of 70 miRNAs, including highly conserved ones (e.g. miR-133 and miR-375, as well honeybee-specific ones (e.g. miR-3745 and miR-3761. Our results put in evidence a broad spectrum of EcR-controlled gene expression during postembryonic development of honeybees, revealing new facets of EcR biology in this social insect.

A NEW CELL CLONE DERIVED FROM TRICHOPLUSIA NI TN5B1-4 CELLS

Institute of Scientific and Technical Information of China (English)

Jian-xiaoTian; Chang-youLi; Gui-lingZheng; Guo-xunLi; PingWang; Granados

2004-01-01

The characteristics of a cultured cell line do not always remain stable and may change upon continuous passage. Most continuous cell lines, even after cloning, possess several genotypes that are constantly changing. There are numerous selective and adaptive culture processes, in addition to genetic instability, that may improve phenotypic change in cell growth, virus susceptibility, gene expression, and production of virus. Similar detrimental effects of long term passaging of insect cells have also been reported for continuous cell lines, for example, Tn5B 1-4 cells, which are the most widely used for the baculovirus expression vector system (BEVS), provide superior production of recombinant proteins,however, this high productivity may be more evident in low passage cells. In this paper, we describe the isolation of a cell clone, Tn5B-40, from low passage Tn5B 1-4 cells. The growth characteristics,productions of virus, and high level of recombinant protein productions were determined. The results showed the susceptibility of both clone and Tn5B 1-4 cells to wild-type AcNPV was approximately the same rate with over 95% of infection; when the cloned cells were infected with recombinant baculoviruses expressing β-galactosidase and secreted alkaline phosphatase (SEAP), expression of the recombinant proteins from the cloned cells exceeded that from the parental Tn5B 1-4 cells.

EC6 safety design improvements

Energy Technology Data Exchange (ETDEWEB)

Yu, S.; Lee, A.G.; Soulard, M. [Candu Energy Inc., Mississauga, ON (Canada)

2014-07-01

The Enhanced CANDU 6 (EC6) builds on the proven high performance design such as the Qinshan CANDU 6 reactor, and has made improvements to safety, operational performance, and has incorporated extensive operational feedback. Completion of all three phases of the pre-licensing design review by the Canadian Regulator - the Canadian Nuclear Safety Commission has provided a higher level of assurance that the EC6 reference design has taken modern regulatory requirements and expectations into account and further confirmed that there are no fundamental barriers to licensing the EC6 design in Canada. The EC6 design is based on the defence-in-depth principles in INSAG-10 and provides further safety features that address the lessons learned from Fukushima. With these safety features, the EC6 design has strengthened accident prevention as the first priority in the defence-in-depth strategy, as outlined in INSAG-10. As well, the EC6 design has incorporated further mitigation measures to provide additional protection of the public and the environment if the preventive measures fail. The EC6 design has an appropriate combination of inherent, passive safety characteristics, engineered features and administrative safety measures to effectively prevent and mitigate severe accident progressions. A strong contributor to the robustness and redundancy of CANDU design is the two-group separation philosophy. This ensures a high degree of independence between safety systems as well as physical separation and functional independence in how fundamental safety functions are provided. This paper will describe the following safety features based on the application of defence-in-depth and design approach to prevent beyond design basis events progressing to severe accidents and to mitigate the consequences if it occurs: Improved steam generator heat sink via a more reliable emergency heat removal system; Increased time before manual field actions are required via enhanced capacity of

The EC-ASEAN COGEN programme

Energy Technology Data Exchange (ETDEWEB)

Pennington, M.; Lacrosse, L. [Asian Institute of Technology (Thailand); Schenkel, Y. [Centre de Recherches Agronomiques (Belgium)

1996-12-31

The EC-ASEAN COGEN Programme is a co-operation programme between the European Commission (EC) and the Association of South East Asian Nations (ASEAN) co-ordinated by the Asian Institute of Technology (AIT), Bangkok, Thailand. Its aim is to accelerate the implementation of proven technologies generating heat and/or power from wood and agroindustrial residues through partnerships between European and ASEAN companies. (orig.)

The EC-ASEAN COGEN programme

Energy Technology Data Exchange (ETDEWEB)

Pennington, M; Lacrosse, L [Asian Institute of Technology (Thailand); Schenkel, Y [Centre de Recherches Agronomiques (Belgium)

1997-12-31

The EC-ASEAN COGEN Programme is a co-operation programme between the European Commission (EC) and the Association of South East Asian Nations (ASEAN) co-ordinated by the Asian Institute of Technology (AIT), Bangkok, Thailand. Its aim is to accelerate the implementation of proven technologies generating heat and/or power from wood and agroindustrial residues through partnerships between European and ASEAN companies. (orig.)

Evaluation of the size segregation of elemental carbon (EC emission in Europe: influence on the simulation of EC long-range transportation

Directory of Open Access Journals (Sweden)

Y. Chen

2016-02-01

Full Text Available Elemental Carbon (EC has a significant impact on human health and climate change. In order to evaluate the size segregation of EC emission in the EUCAARI inventory and investigate its influence on the simulation of EC long-range transportation in Europe, we used the fully coupled online Weather Research and Forecasting/Chemistry model (WRF-Chem at a resolution of 2 km focusing on a region in Germany, in conjunction with a high-resolution EC emission inventory. The ground meteorology conditions, vertical structure and wind pattern were well reproduced by the model. The simulations of particle number and/or mass size distributions were evaluated with observations at the central European background site Melpitz. The fine mode particle concentration was reasonably well simulated, but the coarse mode was substantially overestimated by the model mainly due to the plume with high EC concentration in coarse mode emitted by a nearby point source. The comparisons between simulated EC and Multi-angle Absorption Photometers (MAAP measurements at Melpitz, Leipzig-TROPOS and Bösel indicated that the coarse mode EC (ECc emitted from the nearby point sources might be overestimated by a factor of 2–10. The fraction of ECc was overestimated in the emission inventory by about 10–30 % for Russia and 5–10 % for Eastern Europe (e.g., Poland and Belarus. This incorrect size-dependent EC emission results in a shorter atmospheric life time of EC particles and inhibits the long-range transport of EC. A case study showed that this effect caused an underestimation of 20–40 % in the EC mass concentration in Germany under eastern wind pattern.

Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells

DEFF Research Database (Denmark)

Blixt, Klas Ola; Lavrova, Olga I; Mazurov, Dmitriy V

2012-01-01

antigenicity remain poorly understood. As a consequence, a broad variety of anti-Tn monoclonal antibodies (mAbs) have been generated. To further investigate the nature and complexity of the Tn antigen, we generated seven different anti-Tn mAbs of IgM and IgG classes raised against human Jurkat T cells, which...... are Tn-positive due to the low activity of T-synthase and mutation in specific chaperone Cosmc. The binding analysis of anti-Tn mAbs with the array of synthetic saccharides, glycopeptides and O-glycoproteins revealed unexpected differences in specificities of anti-Tn mAbs. IgM mAbs bound the terminal Gal...

Transposition of Tn5096 from a temperature-sensitive transducible plasmid in Streptomyces spp.

OpenAIRE

McHenney, M A; Baltz, R H

1991-01-01

Transposon Tn5096 was inserted into a derivative of the temperature-sensitive plasmid pMT660 containing the bacteriophage FP43 pac site. The resulting plasmid, pRHB126, was transduced by FP43 into several Streptomyces species. Tn5096 transposed from pRHB126 into different sites in the genomes of Streptomyces ambofaciens, Streptomyces cinnamonensis, Streptomyces coelicolor A3(2), Streptomyces fradiae, Streptomyces griseofuscus, and Streptomyces thermotolerans.

HTR-TN achievements and prospects for future developments

International Nuclear Information System (INIS)

Hittner, D.; Angulo, C.; Basini, V.; Bogusch, E.; Breuil, E.; Buckthorpe, D.; Chauvet, V.; Futterer, M.A.; Van Heek, A.; Von Lensa, W.; Yvon, P.

2011-01-01

It is already 10 years since the (European) High Temperature Reactor Technology Network (HTR-TN) launched a program for development of HTR technology, which expanded through three successive Euratom framework programs, with many projects in line with the network strategy. Widely relying in the beginning on the legacy of the former European HTR developments (DRAGON, AVR, THTR, etc.) that it contributed to safeguard, this program led to advances in HTR/VHTR technologies and produced significant results, which can contribute to the international cooperation through Euratom involvement in the Generation IV International Forum (GIF). the main achievements of the European program, performed in complement to efforts made in several European countries and other GIF partners, are presented: they concern the validation of computer codes (reactor physics, as well as system transient analysis from normal operation to air ingress accident and fuel performance in normal and accident conditions), materials (metallic materials for vessel, direct cycle turbines and intermediate heat exchanger, graphite, etc.), component development, fuel manufacturing and irradiation behavior, and specific HTR waste management (fuel and graphite). Key experiments have been performed or are still ongoing, like irradiation of graphite and of fuel material (PYCASSO experiment), high burn-up fuel PIE, safety test and isotopic analysis, IHX mock-up thermohydraulic test in helium atmosphere, air ingress experiment for a block type core, etc. Now HTR-TN partners consider that it is time for Europe to go a step forward toward industrial demonstration. In line with the orientations of the 'Strategic Energy Technology Plan (SET-Plan)' recently issued by the European Commission that promotes a strategy for development of low-carbon energy technologies and mentions Generation IV nuclear systems as part of key technologies, HTR-TN proposes to launch a program for extending the contribution of nuclear energy to

A inter-relação das sialomucinas (antígenos Tn e Stn com o adenocarcinoma no esôfago de Barrett Relationship of the sialomucins (Tn and Stn antigens with adenocarcinoma in Barrett's esophagus

Directory of Open Access Journals (Sweden)

Plínio Conte de Faria Júnior

2007-08-01

Full Text Available OBJETIVO: O esôfago de Barrett (EB é conseqüência do refluxo gastroesofágico crônico e considerado fator de risco para o desenvolvimento de adenocarcinoma. Estudos do muco, em especial das mucinas ácidas representadas pelas sialomucinas presentes nas células caliciformes, mostraram que na metaplasia do tipo intestinal, o epitélio do órgão pode expressar antígenos denominados Tn e Stn. Estes antígenos já foram analisados em tumores gástricos e colônicos, porém não foram encontradas referências à sua utilização no EB. Este trabalho objetivou analisar estes antígenos em doentes com EB e em adenocarcinoma associado ao EB. MÉTODOS: Foram estudados, utilizando testes imunohistoquímicos, os antígenos Tn e Stn, nas biópsias endoscópicas de 29 doentes com EB, sete com adenocarcinoma no EB, além de oito indivíduos com epitélio esofágico normal. RESULTADOS: Nas células caliciformes, foi observada positividade para Stn em 100% dos casos e para Tn em 48% dos casos. Nas células colunares, o Stn foi sempre negativo, enquanto o Tn foi positivo em 100% dos casos. Entretanto, nos doentes com adenocarcinoma no EB, a positividade para ambos os antígenos foi de 100%. Nos indivíduos normais, houve positividade para o antígeno Tn e negatividade para Stn em todos os casos (100%. CONCLUSÃO: É provável que nos doentes com EB a positividade para o Tn, à semelhança do ocorrido quanto à positividade do mesmo antígeno nos portadores de adenocarcinoma, possa significar maior suscetibilidade para ocorrência futura de câncer. Assim, a pesquisa das sialomucinas poderá ser rotineiramente utilizada, contribuindo como fator prognóstico para desenvolvimento de adenocarcinoma no EB.OBJECIVE: Barrett's esophagus (BE is a consequence of chronic gastroesophageal reflux and is considered a risk factor for adenocarcinoma. The study of the mucus, especially acid mucins, such as the sialomucins in the goblet cells which characterize BE, showed

Roles of major organizations in EC for decision making. EC no ishi kettei ni okeru shuyo kikan no yakuwari

Energy Technology Data Exchange (ETDEWEB)

Kodama, M.

1992-12-01

This paper considers authorization powers held by the major organizations in the EC, with the Maastricht Treaty kept in mind. One of the objectives of establishing the EC is to harmonize and develop the economic activities in the community on the whole, and promote making closer the relations among the member nations. The EC's supernationality has two aspects: finances (using financial sources from externally common tariffs as the EC's independent financial resources) and legislations (member nations delegating their own powers to the international organization). Organizations involving in the EC legislations are the European Assembly, the board of ministers, and the EC Committee. The Assembly has deciding powers at high levels on the EC budget decision, as well as vetoing power on the budget. The board of ministers is provided with deciding powers to assure achievement of the objectives defined in the official requirements. The Committee has a supernational character that each committee member can act independently free from being subjected to orders from his or her native country. Practically, however, the authorization relationship among the organizations has confrontations over the interests of the organizations and member nations. There have been such movements in this situation as the Luxemburg compromises, actions at the agricultural ministers meeting, and preparation of the unified European protocol. 2 figs., 4 tabs.

Public Availability to ECS Collected Datasets

Science.gov (United States)

Henderson, J. F.; Warnken, R.; McLean, S. J.; Lim, E.; Varner, J. D.

2013-12-01

Coastal nations have spent considerable resources exploring the limits of their extended continental shelf (ECS) beyond 200 nm. Although these studies are funded to fulfill requirements of the UN Convention on the Law of the Sea, the investments are producing new data sets in frontier areas of Earth's oceans that will be used to understand, explore, and manage the seafloor and sub-seafloor for decades to come. Although many of these datasets are considered proprietary until a nation's potential ECS has become 'final and binding' an increasing amount of data are being released and utilized by the public. Data sets include multibeam, seismic reflection/refraction, bottom sampling, and geophysical data. The U.S. ECS Project, a multi-agency collaboration whose mission is to establish the full extent of the continental shelf of the United States consistent with international law, relies heavily on data and accurate, standard metadata. The United States has made it a priority to make available to the public all data collected with ECS-funding as quickly as possible. The National Oceanic and Atmospheric Administration's (NOAA) National Geophysical Data Center (NGDC) supports this objective by partnering with academia and other federal government mapping agencies to archive, inventory, and deliver marine mapping data in a coordinated, consistent manner. This includes ensuring quality, standard metadata and developing and maintaining data delivery capabilities built on modern digital data archives. Other countries, such as Ireland, have submitted their ECS data for public availability and many others have made pledges to participate in the future. The data services provided by NGDC support the U.S. ECS effort as well as many developing nation's ECS effort through the U.N. Environmental Program. Modern discovery, visualization, and delivery of scientific data and derived products that span national and international sources of data ensure the greatest re-use of data and

The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.

Directory of Open Access Journals (Sweden)

Richard Beatson

Full Text Available Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific glyco-antigens that can interact with cells of the immune system through carbohydrate binding lectins. Two glyco-epitopes that are found expressed by many carcinomas are Tn (GalNAc-Ser/Thr and STn (NeuAcα2,6GalNAc-Ser/Thr. These glycans can be carried on many mucin-type glycoproteins including MUC1. We show that the majority of breast cancers carry Tn within the same cell and in close proximity to extended glycan T (Galβ1,3GalNAc the addition of Gal to the GalNAc being catalysed by the T synthase. The presence of active T synthase suggests that loss of the private chaperone for T synthase, COSMC, does not explain the expression of Tn and STn in breast cancer cells. We show that MUC1 carrying both Tn or STn can bind to the C-type lectin MGL and using atomic force microscopy show that they bind to MGL with a similar dead adhesion force. Tumour associated STn is associated with poor prognosis and resistance to chemotherapy in breast carcinomas, inhibition of DC maturation, DC apoptosis and inhibition of NK activity. As engagement of MGL in the absence of TLR triggering may lead to anergy, the binding of MUC1-STn to MGL may be in part responsible for some of the characteristics of STn expressing tumours.

Dual EC : a standardized back door

NARCIS (Netherlands)

Bernstein, D.J.; Lange, T.; Niederhagen, R.F.

2015-01-01

Dual EC is an algorithm to compute pseudorandom numbers starting from some random input. Dual EC was standardized by NIST, ANSI, and ISO among other algorithms to generate pseudorandom numbers. For a long time this algorithm was considered suspicious -- the entity designing the algorithm could have

76 FR 35909 - Temporary Concession Contract for Big South Fork National Recreation Area, TN/KY

Science.gov (United States)

2011-06-20

... Recreation Area, TN/KY. SUMMARY: Pursuant to 36 CFR 51.24, public notice is hereby given that the National... Concession Contract for Big South Fork National Recreation Area, TN/KY AGENCY: National Park Service... services within Big South Fork National Recreation Area, Tennessee and Kentucky, for a term not to exceed 3...

A critical evaluation of the Beckman Coulter Access hsTnI: Analytical performance, reference interval and concordance.

Science.gov (United States)

Pretorius, Carel J; Tate, Jillian R; Wilgen, Urs; Cullen, Louise; Ungerer, Jacobus P J

2018-05-01

We investigated the analytical performance, outlier rate, carryover and reference interval of the Beckman Coulter Access hsTnI in detail and compared it with historical and other commercial assays. We compared the imprecision, detection capability, analytical sensitivity, outlier rate and carryover against two previous Access AccuTnI assay versions. We established the reference interval with stored samples from a previous study and compared the concordances and variances with the Access AccuTnI+3 as well as with two commercial assays. The Access hsTnI had excellent analytical sensitivity with the calibration slope 5.6 times steeper than the Access AccuTnI+3. The detection capability was markedly improved with the SD of the blank 0.18-0.20 ng/L, LoB 0.29-0.33 ng/L and LoD 0.58-0.69 ng/L. All the reference interval samples had a result above the LoB value. At a mean concentration of 2.83 ng/L the SD was 0.28 ng/L (CV 9.8%). Carryover (0.005%) and outlier (0.046%) rates were similar to the Access AccuTnI+3. The combined male and female 99th percentile reference interval was 18.2 ng/L (90% CI 13.2-21.1 ng/L). Concordance amongst the assays was poor with only 16.7%, 19.6% and 15.2% of samples identified by all 4 assays as above the 99th, 97.5th and 95th percentiles. Analytical imprecision was a minor contributor to the observed variances between assays. The Beckman Coulter Access hsTnI assay has excellent analytical sensitivity and precision characteristics close to zero. This allows cTnI measurement in all healthy individuals and the capability to identify numerically small differences between serial samples as statistically significant. Concordance in healthy individuals remains poor amongst assays. Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.

Experimental manipulation of TN:TP ratiossuppress cyanobacterial biovolume and microcystinconcentration in large-scale in situ mesocosms

Science.gov (United States)

Harris, Theodore D.; Wilhelm, Frank M.; Graham, Jennifer L.; Loftin, Keith A.

2014-01-01

A global dataset was compiled to examine relations between the total nitrogen to total phosphorus ratio (TN:TP) and microcystin concentration in lakes and reservoirs. Microcystin concentration decreased as TN:TP ratios increased, suggesting that manipulation of the TN:TP ratio may reduce microcystin concentrations. This relationship was experimentally tested by adding ammonium nitrate to increase the TN:TP ratio in large-scale (70 m3), in situ mesocosms located in a eutrophic reservoir that routinely experiences toxic blooms of cyanobacteria. At a TN:TP ratio >75:1, chlorophytes dominated the phytoplankton community in the mesocosms, while cyanobacterial biovolume was significantly reduced and microcystin was not detected. In contrast, the unmanipulated reservoir was dominated by cyanobacteria, and microcystin was detected. Secchi depths were 1.1 to 1.8 times greater in the mesocosms relative to the reservoir. Cladoceran zooplankton had a larger body size (0.14 mm on average) in the mesocosms compared to conspecifics in the reservoir, which was likely related to the higher quality food. Combined, these empirical and experimental data indicate that although nutrient addition is counterintuitive to current cyanobacteria management practices, increasing the TN:TP ratio by adding nitrogen may be a potential short-term management strategy to reduce cyanobacteria and cyanotoxins when other alternatives (e.g., phosphorus reduction) are not possible. Additional experimental studies with careful controls are needed to define best management practices and identify any potential unintended consequences before nitrogen addition is implemented as a lake and reservoir management practice.

Programming Amazon EC2

CERN Document Server

Vliet, Jurg

2011-01-01

If you plan to use Amazon Web Services to run applications in the cloud, the end-to-end approach in this book will save you needless trial and error. You'll find practical guidelines for designing and building applications with Amazon Elastic Compute Cloud (EC2) and a host of supporting AWS tools, with a focus on critical issues such as load balancing, monitoring, and automation. How do you move an existing application to AWS, or design your application so that it scales effectively? How much storage will you require? Programming Amazon EC2 not only helps you get started, it will also keep y

Evaluation of the size segregation of elemental carbon (EC) emission in Europe: Influence on the simulation of EC long-range transportation

NARCIS (Netherlands)

Chen, Y.; Cheng, Y.F.; Nordmann, S.; Birmili, W.; Denier Van Der Gon, H.A.C.; Ma, N.; Wolke, R.; Wehner, B.; Sun, J.; Spindler, G.; Mu, Q.; Pöschl, U.; Su, H.; Wiedensohler, A.

2016-01-01

Elemental Carbon (EC) has a significant impact on human health and climate change. In order to evaluate the size segregation of EC emission in the EUCAARI inventory and investigate its influence on the simulation of EC long-range transportation in Europe, we used the fully coupled online Weather

The TN-GEMINI: experience on a versatile alpha waste transport container

International Nuclear Information System (INIS)

Roland, V.; Chanzy, Y.

2001-01-01

The present paper discusses experience gained in moving alpha wastes and its teachings regarding transport aspects of D and D. Alpha wastes are generated in fuel cycle facilities such as those involved in reprocessing, in manufacture of mixed oxide fuel, and by research laboratories. If a significant amount of wastes has to be transported, then a Type B packaging is required. Developed by Transnucleaire and COGEMA, the TN GEMINI container enables nuclear facilities operators to optimise their alpha waste transport management, and more generally contribute to their D and D projects. After describing succinctly the design of the TN GEMINI, the paper will explain how the packaging is being operated. Teachings from experience will be shared. (orig.)

Development Of Protocols For Simultaneous Measurements Of Rn, Tn Using Nuclear Track Detectors And Trial Application In Mining Areas Of Vietnam

International Nuclear Information System (INIS)

Bui Dac Dung; Trinh Van Giap; Le Dinh Cuong; Tran Khanh Minh; Nguyen Huu Quyet; Nguyen Van Khanh; Tran Ngoc Toan

2013-01-01

Radioactive gases Radon (Rn) and Thoron (Tn) contribute of more than 50% of natural radiation dose. However, separate measurements of Rn and Tn have not been paid enough attention. An Intergovernmental Cooperation Project was conducted at the Institute for Nuclear Science and Technology with the help from Hungarian experts. The main tasks of the project were to finalize 02 protocols for simultaneous measurements of Rn and Tn using nuclear track detectors and to test these protocols in investigating the concentrations of Rn and Tn, calculating the natural dose due to Rn and Tn, and evaluating the increased radiation dose and radiation safety due to mining activities. Main results of the project include 02 protocols for simultaneous measurements of Rn and Tn and the test results in the mining areas. Rn and Tn concentrations inside the coal mining tunnels are in the average level of Vietnam and the world. Tn concentration inside the factory for separating Zircon at the Ha Tinh Zircon Processing Plant was found to be very high, up to 2931 Bq/m 3 . Based on annual effective dose calculation, workers inside the factory for separating Zircon at the Ha Tinh Zircon Processing Plant could receive an annual effective dose due to Rn and Tn of 4.890 mSv/year, and the increasing dose of 4.710 mSv/year is for higher than 1 mSv/year recommended by the IAEA. (author)

Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization

Czech Academy of Sciences Publication Activity Database

Kozáková, Hana; Schwarzer, Martin; Tučková, Ludmila; Šrůtková, Dagmar; Czarnowska, E.; Rosiak, I.; Hudcovic, Tomáš; Schabussova, I.; Hermanová, Petra; Zákostelská, Zuzana; Aleksandrzak-Piekarczyk, T.; Koryszewska-Baginska, A.; Tlaskalová-Hogenová, Helena; Cukrowska, B.

2016-01-01

Roč. 13, č. 2 (2016), s. 251-262 ISSN 1672-7681 R&D Projects: GA ČR(CZ) GAP304/11/1252; GA ČR GA303/09/0449; GA MŠk 7AMB15AT025 Institutional support: RVO:61388971 Keywords : allergic sensitization * germ-free * intestinal barrier Subject RIV: EC - Immunology Impact factor: 5.897, year: 2016

The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL

DEFF Research Database (Denmark)

Beatson, Richard; Maurstad, Gjertrud; Picco, Gianfranco

2015-01-01

Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific glyco-antigens that can interact with cells of the immune system through...... carbohydrate binding lectins. Two glyco-epitopes that are found expressed by many carcinomas are Tn (GalNAc-Ser/Thr) and STn (NeuAcα2,6GalNAc-Ser/Thr). These glycans can be carried on many mucin-type glycoproteins including MUC1. We show that the majority of breast cancers carry Tn within the same cell...

Induction of the Tn10 Precise Excision in E. coli Cells after Accelerated Heavy Ions Irradiation

CERN Document Server

Zhuravel, D V

2003-01-01

The influence of the irradiation of different kinds on the indication of the structural mutations in the bacteria Escherichia coli is considered. The regularities of the Tn10 precise excision after accelerated ^{4}He and ^{12}C ions irradiations with different linear energy transfer (LET) were investigated. Dose dependences of the survival and relative frequency of the Tn10 precise excision were obtained. It was shown, that the relative frequency of the Tn10 precise excision is the exponential function from the irradiation dose. Relative biological efficiency (RBE), and relative genetic efficiency (RGE) were calculated, and were treated as the function of the LET.

Tn7::In2-8 dispersion in multidrug resistant isolates of Acinetobacter baumannii from Chile Dispersión de Tn7::In2-8 en aislamientos multirresistentes de Acinetobacter baumannii de Chile

Directory of Open Access Journals (Sweden)

M. S. Ramírez

2010-06-01

Full Text Available Acinetobacter baumannii is considered an important pathogen in our hospital environment having a well-known capacity to acquire different mechanisms of antibiotic resistance. Previous studies in our laboratory had exposed the high dispersion of class 2 integrons in this species. In the present study, we analyzed 7 multiresistant intI2 positive A. baumannii isolates, 6 of which were found to harbour the Tn7::In2-8 element. Our results demonstrate the unusually high distribution of Tn7::In2-8 among different A. baumannii clones from Chile, suggesting a particular behavior of these elements at geographical level.Acinetobacter baumannii, patógeno de importancia clínica en el ámbito hospitalario, es reconocido como un microorganismo que posee la capacidad de evolucionar rápidamente hacia la multirresistencia. Estudios previos efectuados en nuestro laboratorio han demostrado la alta dispersión de los integrones de clase 2 en aislamientos de esta especie. En el presente trabajo se analizaron 7 aislamientos de Acinetobacter baumannii multirresistentes portadores de la integrasa de clase 2, 6 de los cuales portaban el inusual arreglo Tn7::In2-8. Nuestros resultados muestran una elevada frecuencia de dispersión del elemento Tn7::In2-8 en diferentes clones circulantes en Chile, lo que sugiere un comportamiento geográfico particular.

The EC discourse on vocational training

DEFF Research Database (Denmark)

Cort, Pia

2009-01-01

This article traces the EC vocational training policy historically and describes the discursive alignments which brought the policy from a ‘common vocational training policy' as laid down in Article 128, in the Treaty of Rome to the Lisbon Lifelong Learning strategy. The argument is that vocational...... EC vocational training policy (Ball, What is policy? Texts, trajectories and toolboxes. Discourse, 13(2), 1993)....

Finite impulse testing (FIT) system for Emergency Cooling System (ECS) in Dhruva

International Nuclear Information System (INIS)

Punekar, Parag; Ramkumar, N.; Kulkarni, U.S.; Darbhea, M.D.; Bharadhwaj, G; Jangra, L.R.; Geetha, Patil; Das, Shantanu; Sonnis, S.T.; Trevedi, P.; Patil, M.B.; Biswas, B.B.

2006-01-01

Finite Impulse Testing (FIT) system for Emergency Cooling System (ECS) is used to check healthiness of ECS logic circuits in an online mode. The ECS is an important safety system that ensures the cooling of reactor core during shutdown state of Main Coolant Pumps (MCPs), and hence FIT-ECS that monitors the health of ECS logic circuits in an online (real time) mode is an important part of it. Based on a Safety Related Unusual Occurrence in ECS system due to the malfunction of its earlier single channel FIT system, the new FIT-ECS system has been designed with new features and is commissioned. The FIT-ECS system feeds the simulated input signals (fine impulses of nominal width 575 μS) to the ECS logic circuits and read the outputs. These output (predicted) signals from ECS logic circuit are processed in the FIT-ECS system and in event of any discrepancy, the FIT-ECS system displays fault signature on local panel, detailed information of the fault on Operator Console (OC), and generates an alarm 'ECS logic Fail' in the control room. FIT-ECS also monitors the inputs and outputs of ECS logic circuit. All the information required is stored as a database that can be subsequently displayed in various formats. ECS system is designated as Category I-A system and is a hardwired system and FIT-ECS monitors the healthiness of the logics of the ECS System is a computerized system. As per IEC 1226, FIT-ECS is categorized as Category I-B system. This paper provides technical information on FIT-ECS system design, its important features, the testing carried on the FIT-ECS system, interconnections of FIT-ECS and ECS and the commissioning experience of FIT-ECS system. (author)

Impacts of climate change on TN load and its control in a River Basin with complex pollution sources.

Science.gov (United States)

Yang, Xiaoying; Warren, Rachel; He, Yi; Ye, Jinyin; Li, Qiaoling; Wang, Guoqing

2018-02-15

It is increasingly recognized that climate change could affect the quality of water through complex natural and anthropogenic mechanisms. Previous studies on climate change and water quality have mostly focused on assessing its impact on pollutant loads from agricultural runoff. A sub-daily SWAT model was developed to simulate the discharge, transport, and transformation of nitrogen from all known anthropogenic sources including industries, municipal sewage treatment plants, concentrated and scattered feedlot operations, rural households, and crop production in the Upper Huai River Basin. This is a highly polluted basin with total nitrogen (TN) concentrations frequently exceeding Class V of the Chinese Surface Water Quality Standard (GB3838-2002). Climate change projections produced by 16 Global Circulation Models (GCMs) under the RCP 4.5 and RCP 8.5 scenarios in the mid (2040-2060) and late (2070-2090) century were used to drive the SWAT model to evaluate the impacts of climate change on both the TN loads and the effectiveness of three water pollution control measures (reducing fertilizer use, constructing vegetative filter strips, and improving septic tank performance) in the basin. SWAT simulation results have indicated that climate change is likely to cause an increase in both monthly average and extreme TN loads in February, May, and November. The projected impact of climate change on TN loads in August is more varied between GCMs. In addition, climate change is projected to have a negative impact on the effectiveness of septic tanks in reducing TN loads, while its impacts on the other two measures are more uncertain. Despite the uncertainty, reducing fertilizer use remains the most effective measure for reducing TN loads under different climate change scenarios. Meanwhile, improving septic tank performance is relatively more effective in reducing annual TN loads, while constructing vegetative filter strips is more effective in reducing annual maximum monthly

Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

DEFF Research Database (Denmark)

Li, Yi-Ping; Ramirez, Santseharay; Jensen, Sanne B

2012-01-01

Chronic infection with hepatitis C virus (HCV) is an important cause of end stage liver disease worldwide. In the United States, most HCV-related disease is associated with genotype 1 infection, which remains difficult to treat. Drug and vaccine development was hampered by inability to culture...... full-length TN infection dose-dependently. Given the unique importance of genotype 1 for pathogenesis, this infectious 1a culture system represents an important advance in HCV research. The approach used and the mutations identified might permit culture development for other HCV isolates, thus......) culture systems in Huh7.5 cells. Here, we developed a highly efficient genotype 1a (strain TN) full-length culture system. We initially found that the LSG substitutions conferred viability to an intergenotypic recombinant composed of TN 5' untranslated region (5'UTR)-NS5A and JFH1 NS5B-3'UTR; recovered...

Everyone talk about EC technology - What's about this technology? AC versus AC technology; Alle reden von EC-Technologie - was bringt sie wirklich? AC- versus EC-Motorentechnik

Energy Technology Data Exchange (ETDEWEB)

Anon.

2010-12-15

Meanwhile, the EC motor technology is the state of the art in fans. In the consciousness of a possible energy conservation, the EC motor technology is demanded to a large extent with the new installations of the customers. But how high are the possible savings actually? A comparative measurement at a condenser of Guentner AG (Fuerstenfeldbruck, Federal Republic of Germany) supports information.

Transitioning high sensitivity cardiac troponin I (hs-cTnI) into routine diagnostic use: More than just a sensitivity issue

LENUS (Irish Health Repository)

Lee, Graham R

2016-04-01

High sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI) assays show analytical, diagnostic and prognostic improvement over contemporary sensitive cTn assays. However, given the importance of troponin in the diagnosis of myocardial infarction, implementing this test requires rigorous analytical and clinical verification across the total testing pathway. This was the aim of this study.

Establishing exchange bias below T-N with polycrystalline Ni0.52Co0.48O/Co bilayers

DEFF Research Database (Denmark)

Berkowitz, A.E.; Hansen, Mikkel Fougt; Tang, Y.J.

2005-01-01

Exchange-coupled bilayers of polycrystalline ferromagnetic (FM) Co on antiferromagnetic (AFM) Ni0.52Co0.48O were investigated with emphasis on the issue of establishing an exchange-bias field, H-E, below the AFM ordering temperature, T-N. It was found that field-cooling the bilayers through T-N p...

78 FR 54168 - Special Local Regulation, Cumberland River, Mile 157.0 to 159.0; Ashland City, TN

Science.gov (United States)

2013-09-03

... Local Regulation, Cumberland River, Mile 157.0 to 159.0; Ashland City, TN AGENCY: Coast Guard, DHS... Special local regulation; Cumberland River, Miles 157.0 to 159.0, Ashland City, TN. (a) Location. The... regulation for the waters of the Cumberland River beginning at mile marker 157.0 and ending at mile marker...

Optimization of high-rate TN removal in a novel constructed wetland integrated with microelectrolysis system treating high-strength digestate supernatant.

Science.gov (United States)

Guo, Luchen; He, Keli; Wu, Shubiao; Sun, Hao; Wang, Yanfei; Huang, Xu; Dong, Renjie

2016-08-01

The potential of high-rate TN removal in three aerated horizontal subsurface-flow constructed wetlands to treat high-strength anaerobic digestate supernatant was evaluated. Different strategies of intermittent aeration and effluent recirculation were applied to compare their effect on nitrogen depuration performance. Additional glucose supply and iron-activated carbon based post-treatment systems were established and examined, respectively, to further remove nitrate that accumulated in the effluents from aerated wetlands. The results showed that intermittent aeration (1 h on:1 h off) significantly improved nitrification with ammonium removal efficiency of 90% (18.1 g/(m(2)·d)), but limited TN removal efficiency (53%). Even though effluent recirculation (a ratio of 1:1) increased TN removal from 53% to 71%, the effluent nitrate concentration was still high. Additional glucose was used as a post-treatment option and further increased the TN removal to 82%; however, this implementation caused additional organic pollution. Furthermore, the iron-activated carbon system stimulated with a microelectrolysis process achieved greater than 85% effluent nitrate removal and resulted in 86% TN removal. Considering the high TN removal rate, aerated constructed wetlands integrated with a microelectrolysis-driven system show great potential for treating high-strength digestate supernatant. Copyright © 2016 Elsevier Ltd. All rights reserved.

Superior Predictive Value for NTproBNP Compared with High Sensitivity cTnT in Dialysis Patients: A Pilot Prospective Observational Study

Directory of Open Access Journals (Sweden)

Luminita Voroneanu

2014-12-01

Full Text Available Background/Aims: The clinical utility of the new biomarker, high sensitivity cardiac T troponin (hs-cTnT is still unclear in dialysis patients. Furthermore, the prognostic value of combining N-terminal pro-B-type natriuretic peptide (NT-pro-BNP and hs-cTnT has not been explored so far. The objective of this pilot study was to determine the utility of hs-cTnT alone versus hs-cTnT in combination with NT-proBNP for predicting death in a stable hemodialysis cohort. Methods: A prospective observational pilot study including 98 chronic asymptomatic hemodialysis patients with a follow up period of 24 months was designed. The cut-off values for NT-proBNP and hs-cTnT were calculated using receiver operating characteristic (ROC analysis, using mortality as an end-point. Based on the cut-off values, the cohort was divided into four groups. Group 1 - NT-proBNP 69.48 ng/l; group 3 - NT-proBNP > 14275 pg/ml and hs-cTnT 14275 pg/ml and hs-cTnT > 69.48 ng/l. Survival for each group was determined using the Kaplan-Meier method and Cox regression analysis. Results: During the follow-up period 16 patients died. According to the ROC curves analysis, the cut-off point for hs-cTnT and for NT-proBNP were 69.43 ng/l (AUC = 0.618; p = 0.04 and 14275 pg/ml (AUC = 0.722; p = 0.003, respectively. In univariate Cox analysis, both hs-cTnT (HR = 3.34; p = 0.016 and NT-proBNP (HR = 5.94; p = 0.01 were predictors of death. In the multivariable Cox proportional hazards model, only NT-pro-BNP levels above the cut-off value remained an independent predictor of all-cause mortality. The combined elevation of both biomarkers did not improve significantly the prognostic value compared with NT-proBNP alone (HR = 6.15 versus HR =4 .78; p = 0.338. Conclusion: NT-pro-BNP is a strong predictor of overall mortality in asymptomatic hemodialysis patients. The addition of hs-cTnT did not improve the prognostic accuracy compared with NT proBNP alone.

Clinical application of combined detection of serum hs-CRP, GMP-140 and cTnI in patients with coronary heart diseases

International Nuclear Information System (INIS)

Qin Jibao; Wu Zhaozeng

2010-01-01

Objective: To explore the clinical significance of changes of serum hs-CRP, GMP-140 and cTnI levels in patients with coronary heart diseases. Methods: Serum GMP-140 (with RIA), cTnI (with ELISA) and hs-CRP (with immuno turbidity method) levels were determined in 91 patients with coronary heart diseases (42 SAP, 34UAP, 15AMI) and 35 controls. Results: Serum hs-CRP, GMP-140, cTnI levels in patients with coronary heart diseases were significantly higher than those in controls (P <0.01). Among the patients with of coronary heart diseases, the magnitude of changes of the levels of serum hs-CRP, GMP-140 and cTnI levels in AMI and UAP groups were significantly larger than those in SAP group (P < 0.05). Serum hs-CRP levels were positively correlated with serum GMP-140 and cTnI levels (r = 0.6214, 0.6023, P < 0.01). Conclusion: Serum hs-CRP, GMP140 and cTnI levels were closely related to the diseases process of coronary heart diseases and were of great clinical importance for assessment of the disease and outcome prediction. (authors)

On the isolation of elemental carbon (EC) for micro-molar 14C accelerator mass spectrometry: development of a hybrid reference material for 14C-EC accuracy assurance, and a critical evaluation of the thermal optical kinetic (TOK) EC isolation procedure

Science.gov (United States)

Currie, L. A.; Kessler, J. D.

2005-10-01

The primary objective of the research reported here has been the development of a hybrid reference material (RM) to serve as a test of accuracy for elemental carbon (EC) isotopic (14C) speciation measurements. Such measurements are vital for the quantitative apportionment of fossil and biomass sources of "soot" (EC), the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement quality, carried out with NIST SRM 1649a (Urban Dust), showed a range of results, but since the "truth" was not known for this natural matrix RM, one had to rely on isotopic-chemical consistency evidence (14C in PAH, EC) of measurement validity (Currie et al., 2002). Components of the new Hybrid RM (DiesApple), however, have known 14C and EC composition, and they are nearly orthogonal (isotopically and chemically). NIST SRM 2975 (Forklift Diesel Soot) has little or no 14C, and its major compositional component is EC; SRM 1515 (Apple Leaves) has the 14C content of biomass-C, and it has little or no EC. Thus, the Hybrid RM can serve as an absolute isotopic test for the absence of EC-mimicking pyrolysis-C (char) from SRM 1515 in the EC isolate of the Hybrid RM, as well as a test for conservation of its dominant soot fraction throughout the isolation procedure. The secondary objective was to employ the Hybrid RM for the comparative evaluation of the thermal optical kinetic (TOK) and thermal optical transmission (TOT) methods for the isolation of EC for micro-molar carbon accelerator mass spectrometry (AMS). As part of this process, the relatively new TOK method was subjected to a critical evaluation and significant development. Key findings of our study are: (1) both methods exhibited biomass-C "leakage"; for TOT, the EC fraction isolated for AMS contained about 8% of the original biomass-C; for TOK, the refractory carbon (RC) isolated contained about 3% of the original biomass-C.; (2) the initial isothermal oxidation stage of

On the isolation of elemental carbon (EC for micro-molar 14C accelerator mass spectrometry: development of a hybrid reference material for 14C-EC accuracy assurance, and a critical evaluation of the thermal optical kinetic (TOK EC isolation procedure

Directory of Open Access Journals (Sweden)

L. A. Currie

2005-01-01

Full Text Available The primary objective of the research reported here has been the development of a hybrid reference material (RM to serve as a test of accuracy for elemental carbon (EC isotopic (14C speciation measurements. Such measurements are vital for the quantitative apportionment of fossil and biomass sources of 'soot' (EC, the tracer of fire that has profound effects on health, atmospheric visibility, and climate. Previous studies of 14C-EC measurement quality, carried out with NIST SRM 1649a (Urban Dust, showed a range of results, but since the 'truth' was not known for this natural matrix RM, one had to rely on isotopic-chemical consistency evidence (14C in PAH, EC of measurement validity (Currie et al., 2002. Components of the new Hybrid RM (DiesApple, however, have known 14C and EC composition, and they are nearly orthogonal (isotopically and chemically. NIST SRM 2975 (Forklift Diesel Soot has little or no 14C, and its major compositional component is EC; SRM 1515 (Apple Leaves has the 14C content of biomass-C, and it has little or no EC. Thus, the Hybrid RM can serve as an absolute isotopic test for the absence of EC-mimicking pyrolysis-C (char from SRM 1515 in the EC isolate of the Hybrid RM, as well as a test for conservation of its dominant soot fraction throughout the isolation procedure. The secondary objective was to employ the Hybrid RM for the comparative evaluation of the thermal optical kinetic (TOK and thermal optical transmission (TOT methods for the isolation of EC for micro-molar carbon accelerator mass spectrometry (AMS. As part of this process, the relatively new TOK method was subjected to a critical evaluation and significant development. Key findings of our study are: (1 both methods exhibited biomass-C 'leakage'; for TOT, the EC fraction isolated for AMS contained about 8% of the original biomass-C; for TOK, the refractory carbon (RC isolated contained about 3% of the original biomass-C.; (2 the initial isothermal oxidation stage

Interaction of a novel Tn (GalNAc alpha 1-->Ser/Thr) glycoprotein with Gal, GalNAc and GlcNAc specific lectins.

Science.gov (United States)

Wu, A M; Wu, J H; Shen, F

1994-01-14

A naturally occurring Tn glycoprotein (Native ASG-Tn) with GalNAc alpha 1-->Ser/Thr as the only carbohydrate side chains, has been prepared from armadillo submandibular glands. In a quantitative precipitin assay, this glycoprotein completely precipitated Maclura pomifera (MPA), Vicia villosa B4 (VVL-B4) and Artocarpus integrifolia (Jacalin, AIL). It also reacted well with Helix pomatia (HPL) and Wistaria floribunda (WFL) and precipitated over 75% of the lectin nitrogen added, but poorly with Ricinus communis agglutinin (RCA1), ricin, peanut (Arachis hypogaea, PNA), Abrus precatorius agglutinin (APA) and Triticum vulgaris (WGA). This finding suggests that this novel Tn-glycoprotein may serve as a useful reagent for differentiating Tn and T specific monoclonal antibodies and lectins.

Dynamic Equilibrium of Cardiac Troponin C's Hydrophobic Cleft and Its Modulation by Ca2+ Sensitizers and a Ca2+ Sensitivity Blunting Phosphomimic, cTnT(T204E).

Science.gov (United States)

Schlecht, William; Dong, Wen-Ji

2017-10-18

Several studies have suggested that conformational dynamics are important in the regulation of thin filament activation in cardiac troponin C (cTnC); however, little direct evidence has been offered to support these claims. In this study, a dye homodimerization approach is developed and implemented that allows the determination of the dynamic equilibrium between open and closed conformations in cTnC's hydrophobic cleft. Modulation of this equilibrium by Ca 2+ , cardiac troponin I (cTnI), cardiac troponin T (cTnT), Ca 2+ -sensitizers, and a Ca 2+ -desensitizing phosphomimic of cTnT (cTnT(T204E) is characterized. Isolated cTnC contained a small open conformation population in the absence of Ca 2+ that increased significantly upon the addition of saturating levels of Ca 2+ . This suggests that the Ca 2+ -induced activation of thin filament arises from an increase in the probability of hydrophobic cleft opening. The inclusion of cTnI increased the population of open cTnC, and the inclusion of cTnT had the opposite effect. Samples containing Ca 2+ -desensitizing cTnT(T204E) showed a slight but insignificant decrease in open conformation probability compared to samples with cardiac troponin T, wild type [cTnT(wt)], while Ca 2+ sensitizer treated samples generally increased open conformation probability. These findings show that an equilibrium between the open and closed conformations of cTnC's hydrophobic cleft play a significant role in tuning the Ca 2+ sensitivity of the heart.

EnviroAtlas - Memphis, TN - Meter-Scale Urban Land Cover (MULC) Data (2012)

Data.gov (United States)

U.S. Environmental Protection Agency — The Memphis, TN EnviroAtlas One Meter-scale Urban Land Cover (MULC) dataset comprises 2,733 km2 around the city of Memphis, surrounding towns, and rural areas. These...

Rapid and efficient introduction of a foreign gene into bacterial artificial chromosome-cloned varicella vaccine by Tn7-mediated site-specific transposition

International Nuclear Information System (INIS)

Somboonthum, Pranee; Koshizuka, Tetsuo; Okamoto, Shigefumi; Matsuura, Masaaki; Gomi, Yasuyuki; Takahashi, Michiaki; Yamanishi, Koichi; Mori, Yasuko

2010-01-01

Using a rapid and reliable system based on Tn7-mediated site-specific transposition, we have successfully constructed a recombinant Oka varicella vaccine (vOka) expressing the mumps virus (MuV) fusion protein (F). The backbone of the vector was our previously reported vOka-BAC (bacterial artificial chromosome) genome. We inserted the transposon Tn7 attachment sequence, LacZα-mini-attTn7, into the region between ORF12 and ORF13 to generate a vOka-BAC-Tn genome. The MuV-F expressing cassette was transposed into the vOka-BAC genome at the mini-attTn7 transposition site. MuV-F protein was expressed in recombinant virus, rvOka-F infected cells. In addition, the MuV-F protein was cleaved in the rvOka-F infected cells as in MuV-infected cells. The growth of rvOka-F was similar to that of the original recombinant vOka without the F gene. Thus, we show that Tn7-mediated transposition is an efficient method for introducing a foreign gene expression cassette into the vOka-BAC genome as a live virus vector.

EC-construction product guideline 89/106/EEC and EC-pressure equipement guideline 97/23/EC; EG-Bauproduktenrichtlinie 89/106/EWG und EG-Druckgeraeterichtlinie 97/23/EG

Energy Technology Data Exchange (ETDEWEB)

Dupin, F. [DVGW Deutscher Verein des Gas- und Wasserfaches e.V., Bonn (Germany)

1998-08-01

For now nearly ten years the EC-directive 90/396/EEC is well established in the gas field. In the meantime other EC-directives are playing a role which cannot be left out of consideration. Particularly the EC-Construction Product Directive (89/106/EEC) and the Pressure Equipment Directive (97/23/EG) constitute a focal point as many key-issues (e.g. scope) are still open, causing thus hotly debated discussions. The present contribution reflects the current consultations at the national and European level, pointing out then the gas-specific features. (orig.) [Deutsch] Seit nahezu zehn Jahren hat sich die EG-Richtlinie 90/396/EWG fuer Gasverbrauchseinrichtungen im europaeischen Gasfach fest etabliert. Inzwischen sind andere EG-Richtlinien ins Spiel gekommen, deren Einfluss nicht ausser Acht gelassen werden kann. Besonders die EG-Bauproduktenrichtlinie (89/106/EWG) und die EG-Druckgeraeterichtlinie (97/23/EG) stehen z.Z. im Mittelpunkt, da viele Schluesselfragen (z.B. Geltungsbereich) noch offen sind und heftige Debatten mit sich bringen. Der vorliegende Beitrag gibt den Stand der auf nationaler und europaeischer Ebene gefuehrten Beratungen wieder und stellt dabei die gasspezifischen Gegebenheiten heraus. (orig.)

R-prime site-directed transposon Tn7 mutagenesis of the photosynthetic apparatus in Rhodopseudomonas capsulata

Energy Technology Data Exchange (ETDEWEB)

Youvan, D C [Univ. of California, Berkeley; Elder, J T; Sandlin, D E; Zsebo, K; Alder, D P; Panopoulos, N J; Marrs, B L; Hearst, J E

1982-01-01

Site-directed mutagenesis of the photosynthetic apparatus (PSA) genes in Rhodopseudomonas capsulata is presented utilizing a transposon Tn7 mutagenized R-prime. The R-prime, pRPS404, bears most of the genes necessary for the differentiation of the photosynthetic apparatus. Mutagenesis of the R-prime with Tn7 in Escherichia coli, conjugation into R. capsulata, and homologous recombination with the wild-type alleles efficiently generates photosynthetic apparatus lesions. Wild-type alleles are lost spontaneously and the Tn7-induced lesions are revealed by subsequent intramolecular recombination between IS21 insertion elements that bracket the prime sequences in direct repeat. The molecular nature of the intermediates involved in the transposition, recombination and deletion have been investigated by Southern hybridization analysis. The spontaneous loss of wild-type alleles after homologous recombination with the chromosome may be of general use to other prokaryotic site-directed transposon mutagenesis schemes. The IS21-mediated deletion of the prime DNA is dependent on the RecA protein in E. coli, generating the parental R-factor bearing one IS21 element. A genetic-physical map exists for a portion of the prime photosynthetic apparatus DNA. When Tn7 is inserted into a bacteriochlorophyll gene in the R-prime and then crossed into R. capsulata, mutants are produced that accumulate a bacteriochlorophyll precursor, which is in excellent agreement with the existing genetic-physical map. This corroborates the mutagenesis scheme.

Newton shows the light: a commentary on Newton (1672) 'A letter … containing his new theory about light and colours…'.

Science.gov (United States)

Fara, Patricia

2015-04-13

Isaac Newton's reputation was initially established by his 1672 paper on the refraction of light through a prism; this is now seen as a ground-breaking account and the foundation of modern optics. In it, he claimed to refute Cartesian ideas of light modification by definitively demonstrating that the refrangibility of a ray is linked to its colour, hence arguing that colour is an intrinsic property of light and does not arise from passing through a medium. Newton's later significance as a world-famous scientific genius and the apparent confirmation of his experimental results have tended to obscure the realities of his reception at the time. This paper explores the rhetorical strategies Newton deployed to convince his audience that his conclusions were certain and unchallengeable. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

Special Issue: Selected papers from ECS'97

DEFF Research Database (Denmark)

1999-01-01

This Special Issue of Analog Integrated Circuits and Signal Processing presents extended versions of selected papers from the First Electronic Circuits and Systems Conference (ECS'97) which was held on September 4-5, 1997, in Bratislava, Slovakia.......This Special Issue of Analog Integrated Circuits and Signal Processing presents extended versions of selected papers from the First Electronic Circuits and Systems Conference (ECS'97) which was held on September 4-5, 1997, in Bratislava, Slovakia....

Clinical relevance of determination the changes of serum cTnI, NPY and PGMP contents after treatment in patients with coronary heart diseases

International Nuclear Information System (INIS)

Ge Hengsong; Ma Chao; Wu Kaixia

2011-01-01

Objective: To explore the clinical significance of changes of serum cTnI, NPY and PGMP levels in patients with coronary heart diseases after treatment. Methods: Serum NPY, PGMP (with RIA), serum cTnI (with Biochemistry) levels were measured in 41 patients with coronary heart diseases both before and after treatment as well as in 35 normal controls. Results: Before treatment, serum cTnI, NPY and PGMP levels were significantly higher than those in controls (P 0.05), but serum PGMP level remained prominently higher (P<0.05). Conclusion: Pathogenesis and progress of CHD, might be closely related to serum cTnI, NPY and PGMP levels. (authors)

EC6 design features and pre-project licensing review

Energy Technology Data Exchange (ETDEWEB)

Yu, S.; Lee, A.G.; Dinh, N.B.; Soulard, M. [CANDU Energy Inc., Mississauga, Ontario, (Canada)

2013-07-01

The Enhanced CANDU 6 (EC6) is the new Generation III CANDU reactor design that meets the most up to date Canadian regulatory requirements and customer expectations. Candu Energy Inc. is finalizing development of the EC6 which incorporates the CANDU 6's well-proven features, and adds enhancements that strengthened reactor safety margin and improved operability. The EC6 builds on the proven high performance design and the defence-in-depth features of CANDU 6 units, and has incorporated extensive operational feedback including lessons learned from Fukushima. This paper will provide status of the engineering program including progress on the pre-licensing review of the EC6 design by the Canadian Regulator, CNSC, and will also highlight the design and safety enhancements incorporated in the EC6 product. Safety enhancements to meet safety goals and to improve robustness of systems to respond to design basis accidents and beyond design basis accidents include: new severe accident recovery and heat removal system; improved emergency heat removal system; faster shutoff rods with improved safety margins; mechanical guaranteed shutdown rods; daily load cycling capability; robust containment with containment filter venting system; and improved backed-up electrical supply and cooling services. (author)

Do Decision 2003/54/EC and Decision no. 1229/2003/EC result in a European market for electricity?

International Nuclear Information System (INIS)

Wenting, F.

2004-01-01

In the summer of 2003 the European Parliament and the European Council issued a new Directive with respect to the internal market for electricity (Directive 2003/54/EC of the European Parliament and of the Council of 26 June 2003 concerning common rules for the internal market in electricity) and Guidelines for trans-European networks in the energy sector (Decision no. 1229/2003/EC). The question is whether these decisions will lead to a European and free market for electricity. It is concluded that this is not yet the case [nl

Seizure threshold to lidocaine is decreased following repeated ECS (electroconvulsive shock)

DEFF Research Database (Denmark)

Kragh, J; Seidelin, J; Bolwig, T G

1993-01-01

Seizure susceptibility to lidocaine was investigated in rats which had received repeated ECS (electroconvulsive shock). In the first experiment three groups of rats received an ECS daily for 18 days, an ECS weekly for 18 weeks, and 18 sham treatments, respectively. Twelve weeks after the last ECS...... all rats received a lidocaine challenge (LC) in the form of an intraperitoneal (IP) injection of lidocaine (65 mg/kg). After the injection the animals were observed for occurrence of motor seizures. A total of 67% (10/15), 47% (7/15), and 0% (0/18) of the daily, weekly, and sham groups, respectively......, had motor seizures in response to the LC. In the second experiment five groups of rats received an ECS daily for 0, 1, 6, 18, and 36 days, respectively. Eighteen weeks after the last ECS all rats received an LC and 0% (0/15), 13% (2/15), 20% (3/15), 53% (8/15), and 58% (7/12), respectively, developed...

In-house preparation of lectin panel and detection of Tn polyagglutination

Directory of Open Access Journals (Sweden)

Sudipta Sekhar Das

2015-01-01

Full Text Available Polyagglutination is a condition in which red cells are agglutinated by ABO-compatible adult human sera, but not by cord blood sera and may be acquired or inherited. Lectins are invaluable reagents in the investigation of red cells polyagglutination. We prepared in-house lectin panel and confirmed Tn polyagglutination in a pregnant lady. The lady was anemic and refused blood transfusion elsewhere due to serological discrepancy. We found ABO discrepancy and an incompatible minor cross-match in the initial investigation and suspected polyagglutination. Confirmation of polyagglutination was done using adult and cord sera. We then used the in-house lectin panels to detect the type of polyagglutination. The agglutination pattern with the various lectins was suggestive of Tn polyagglutination, which was further supported by the enzyme study. Most blood banks in India lack commercial lectin panels because of cost and procurement difficulty. Lectins play an important role in the diagnosis and differentiation of polyagglutination and immunohematological management of patient. The important and basic lectins can be prepared in-house using specific raw seeds following standardized protocol.

In-house preparation of lectin panel and detection of Tn polyagglutination.

Science.gov (United States)

Das, Sudipta Sekhar

2015-01-01

Polyagglutination is a condition in which red cells are agglutinated by ABO-compatible adult human sera, but not by cord blood sera and may be acquired or inherited. Lectins are invaluable reagents in the investigation of red cells polyagglutination. We prepared in-house lectin panel and confirmed Tn polyagglutination in a pregnant lady. The lady was anemic and refused blood transfusion elsewhere due to serological discrepancy. We found ABO discrepancy and an incompatible minor cross-match in the initial investigation and suspected polyagglutination. Confirmation of polyagglutination was done using adult and cord sera. We then used the in-house lectin panels to detect the type of polyagglutination. The agglutination pattern with the various lectins was suggestive of Tn polyagglutination, which was further supported by the enzyme study. Most blood banks in India lack commercial lectin panels because of cost and procurement difficulty. Lectins play an important role in the diagnosis and differentiation of polyagglutination and immunohematological management of patient. The important and basic lectins can be prepared in-house using specific raw seeds following standardized protocol.

Ketone EC50 values in the Microtox test.

Science.gov (United States)

Chen, H F; Hee, S S

1995-03-01

The Microtox EC50 values for the following ketones are reported in the following homologous series: straight chain methyl ketones (acetone, 2-butanone, 2-pentanone, 2-hepatonone, 2-octanone, 2-decanone, and 2-tridecanone); methyl ketones substituted at one alpha carbon (3-methyl-2-butanone; 3,3-dimethyl-2-butanone); methyl substituted at two alpha carbons (2,4-dimethyl-3-pentanone; 2,2,4,4-tetramethyl-3-pentanone); phenyl groups replacing methyl in acetone (acetophenone; benzophenone); methyl groups substituted at the alpha carbons of cyclohexanone; and 2,3- 2,4-, and 2,5-hexanediones, most for the first time. While there were linear relationships between log EC50 and MW for the straight chain methyl ketones, and for methyl substitution at the alpha carbon for methyl ketones, there were no other linear relationships. As molecular weight increased, the EC50 values of soluble ketones decreased; as distance between two carbonyl groups decreased so too did EC50 values. Thus, for the ketones the geometry around the carbonyl group is an important determinant of toxicity as well as MW, water solubility, and octanol/water coefficient.

Nuclear power plant performance in the EC in 1978

International Nuclear Information System (INIS)

Anon.

1979-01-01

According to the report presented by the Statistical Office of the Ec, nuclear electricity generation in the nine EC countries has been increased in 1978 by 11% to a net value of 115 TWh as compared to the year before. Installed capacity went up by 18.6% to a net value of 24. 000 MWe at the end of the year. The mean availability period has been close to the hitherto best value of 6000 h/a. The share of nuclear energy in total electricity generation in the EC rose by 0.5% to 10.5%. (orig.) [de

Assessing Tn5 and Sleeping Beauty for transpositional transgenesis by cytoplasmic injection into bovine and ovine zygotes

Science.gov (United States)

Bevacqua, R. J.; Fernandez-Martin, R.; Canel, N. G.; Gibbons, A.; Texeira, D.; Lange, F.; Vans Landschoot, G.; Savy, V.; Briski, O.; Hiriart, M. I.; Grueso, E.; Ivics, Z.; Taboga, O.; Kues, W. A.; Ferraris, S.

2017-01-01

Transgenic domestic animals represent an alternative to bioreactors for large-scale production of biopharmaceuticals and could also provide more accurate biomedical models than rodents. However, their generation remains inefficient. Recently, DNA transposons allowed improved transgenesis efficiencies in mice and pigs. In this work, Tn5 and Sleeping Beauty (SB) transposon systems were evaluated for transgenesis by simple cytoplasmic injection in livestock zygotes. In the case of Tn5, the transposome complex of transposon nucleic acid and Tn5 protein was injected. In the case of SB, the supercoiled plasmids encoding a transposon and the SB transposase were co-injected. In vitro produced bovine zygotes were used to establish the cytoplasmic injection conditions. The in vitro cultured blastocysts were evaluated for reporter gene expression and genotyped. Subsequently, both transposon systems were injected in seasonally available ovine zygotes, employing transposons carrying the recombinant human factor IX driven by the beta-lactoglobulin promoter. The Tn5 approach did not result in transgenic lambs. In contrast, the Sleeping Beauty injection resulted in 2 lambs (29%) carrying the transgene. Both animals exhibited cellular mosaicism of the transgene. The extraembryonic tissues (placenta or umbilical cord) of three additional animals were also transgenic. These results show that transpositional transgenesis by cytoplasmic injection of SB transposon components can be applied for the production of transgenic lambs of pharmaceutical interest. PMID:28301581

Performances of TN {sup registered} 24 E. An AREVA used fuel transport and interim storage cask for the German market

Energy Technology Data Exchange (ETDEWEB)

Brion, Thomas [AREVA TN International, Montigny Le Bretonneux (France)

2013-07-01

Part of the AREVA Group, TN International offers a complete range of transport and interim storage solutions for radioactive materials throughout the entire nuclear fuel cycle. A world leader in its sector, TN International has supported for 50 years the expansion of the nuclear industry, in particular by providing expertise in secure packing systems for the storage of used fuel assemblies. As an answer to EON and EnBW, two German utilities, needs, TN International has designed and manufactured the TN {sup registered} 24E cask, offering the following high level performances: 1. transport and storage over a period of 40 years of up to 21 PWR spent nuclear fuel (SNF), allowing for example to load up to 17 MOX fuel assemblies and 4 UOX SNF. 2. high flexibility in the fuel assemblies loading plans, inducing no general predefined constraints with regards to the MOX or UOX fuel positions in the basket of the cask Safety margin related to radioprotection, thermal and mechanical behaviour of the fuel assemblies can be calculated loading plan per loading plan. (orig.)

and alanine (EC. 2.6.1.2) transaminases, and alkaline phosphatase

African Journals Online (AJOL)

The activities of aspartate (E.C. 2.6.1.1) and alanine (E.C. 2.6.1.2) transaminases (AST and ALT, respectively), and alkaline phosphatase (ALP) (E.C. 3.1.3.1) were determined in erythrocytes obtained from 20 HbAA, 15 HbAS and 12 HbSS human subjects. The results showed that the three enzymes had different levels of ...

Detección del antígeno Tn en tumores epiteliales con la lectina de Vicia villosa isolectina B4.

Directory of Open Access Journals (Sweden)

Catalina Limpias

2010-10-01

Full Text Available Antecedentes. Los epítopes T, Tn y sTn, se expresan en un alto porcentaje de tumores epiteliales y pueden detectarse con anticuerpos monoclonales y lectinas. Objetivo. Evaluar diferencias de expresión del antígeno Tn en cortes histológicos de epitelios no neoplásicos y tumores epiteliales mediante isolectina B4 de Vicia villosa. Material y métodos. Se evaluaron semicuantitativamente localización, intensidad y porcentaje de expresión del antígeno en carcinomas in-situ e infiltrantes y epitelios no neoplásicos de cérvix, seno y urotelio, mediante isolectina B4. Resultados La expresión de Tn en cérvix predominó en membrana de células no neoplásicas y citoplasma de células tumorales; su intensidad fue mayor en carcinomas in-situ e infiltrantes comparado con epitelio no neoplásico aunque en este el porcentaje de expresión fue mayor. En seno, la expresión de Tn fue predominantemente citoplasmática con intensidad similar, el porcentaje de expresión fué mayor en carcinomas ductales in-situ e infiltrantes. En urotelio no neoplásico y tumoral la expresión de Tn predominó en citoplasma; la intensidad y el porcentaje de expresión fueron mayores en neoplasias no invasivas de bajo y alto grado, mientras que en urotelio no neoplásico fue baja y no hubo tendencia definida en tumores infiltrantes. Conclusiones. La detección del antígeno Tn mediante la lectina VVB4 mostró una mayor extensión de marcación en carcinomas ductales de seno en relación con el epitelio no neoplásico, pero no mostró una tendencia definida entre el tejido normal, ni diferentes etapas del desarrollo de los tumores de cérvix y urotelio. Estos hallazgos pueden atribuirse a la heterogeneidad de los procesos carcinogénicos o a que la especificidad de la lectina VVB4 no está restringida a este antígeno.

75 FR 69398 - Foreign-Trade Zone 78-Nashville, TN; Application for Expansion

Science.gov (United States)

2010-11-12

... Company, 1800 Zinc Plant Road, Clarksville; and Proposed Site 12 (451.0 acres)--Gallatin Industrial Center..., TN; Application for Expansion An application has been submitted to the Foreign-Trade Zones Board (the... application was submitted pursuant to the provisions of the Foreign- Trade Zones Act, as amended (19 U.S.C...

Integrative Gene Cloning and Expression System for Streptomyces sp. US 24 and Streptomyces sp. TN 58 Bioactive Molecule Producing Strains

Directory of Open Access Journals (Sweden)

Samiha Sioud

2009-01-01

Full Text Available Streptomyces sp. US 24 and Streptomyces sp. TN 58, two strains producing interesting bioactive molecules, were successfully transformed using E. coli ET12567 (pUZ8002, as a conjugal donor, carrying the integrative plasmid pSET152. For the Streptomyces sp. US 24 strain, two copies of this plasmid were tandemly integrated in the chromosome, whereas for Streptomyces sp. TN 58, the integration was in single copy at the attB site. Plasmid pSET152 was inherited every time for all analysed Streptomyces sp. US 24 and Streptomyces sp. TN 58 exconjugants under nonselective conditions. The growth, morphological differentiation, and active molecules production of all studied pSET152 integrated exconjugants were identical to those of wild type strains. Consequently, conjugal transfer using pSET152 integration system is a suitable means of genes transfer and expression for both studied strains. To validate the above gene transfer system, the glucose isomerase gene (xylA from Streptomyces sp. SK was expressed in strain Streptomyces sp. TN 58. Obtained results indicated that heterologous glucose isomerase could be expressed and folded effectively. Glucose isomerase activity of the constructed TN 58 recombinant strain is of about eighteenfold higher than that of the Streptomyces sp. SK strain. Such results are certainly of importance due to the potential use of improved strains in biotechnological process for the production of high-fructose syrup from starch.

Novel Tn916-like elements confer aminoglycoside/macrolide co-resistance in clinical isolates of Streptococcus gallolyticus ssp. gallolyticus.

Science.gov (United States)

Kambarev, Stanimir; Pecorari, Frédéric; Corvec, Stéphane

2018-02-09

Streptococcus gallolyticus ssp. gallolyticus (Sgg) is a commensal bacterium and an opportunistic pathogen. In humans it has been clinically associated with the incidence of colorectal cancer (CRC) and epidemiologically recognized as an emerging cause of infective endocarditis (IE). The standard therapy of Sgg includes the administration of a penicillin in combination with an aminoglycoside. Even though penicillin-resistant isolates have still not been reported, epidemiological studies have shown that this microbe is a reservoir of multiple acquired genes, conferring resistance to tetracyclines, aminoglycosides, macrolides and glycopeptides. However, the underlying antibiotic resistance mobilome of Sgg remains poorly understood. To investigate the mobile genetic basis of antibiotic resistance in multiresistant clinical Sgg. Isolate NTS31106099 was recovered from a patient with IE and CRC at Nantes University Hospital, France and studied by Illumina WGS and comparative genomics. Molecular epidemiology of the identified mobile element(s) was performed using antibiotic susceptibility testing (AST), PCR, PFGE and WGS. Mobility was investigated by PCR and filter mating. Two novel conjugative transposons, Tn6263 and Tn6331, confer aminoglycoside/macrolide co-resistance in clinical Sgg. They display classical family Tn916/Tn1545 modular architecture and harbour an aph(3')-III→sat4→ant(6)-Ia→erm(B) multiresistance gene cluster, related to pRE25 of Enterococcus faecium. These and/or closely related elements are highly prevalent among genetically heterogeneous clinical isolates of Sgg. Previously unknown Tn916-like mobile genetic elements conferring aminoglycoside/macrolide co-resistance make Sgg, collectively with other gut Firmicutes such as enterococci and eubacteria, a potential laterally active reservoir of these antibiotic resistance determinants among the mammalian gastrointestinal microbiota. © The Author(s) 2018. Published by Oxford University Press on behalf

Integrated Detection of Pathogens and Host Biomarkers for Wounds

Science.gov (United States)

2012-04-01

None None TN631B Enterococcus faecium None ZB191B Enterobacter cloacae Acinetobacter baumannii Enterobacter cloacae plasmid pEC01 These initial...Streptomyces roseosporus HERV K113 ZB191B Enterobacter cloacae Enterobacter cloacae plasmid pEC01 Escherichia coli plasmid pIGRW12 Plasmid

Energy conservation in the EC glass industry

Energy Technology Data Exchange (ETDEWEB)

Waal, H. de [TNO Institute of Applied Physics, Delft (Netherlands)

1994-12-31

The data presented in this survey are based mainly on a recent study, performed by the Energy Technology Support Unit ETSU. Harwell Laboratory, United Kingdom, in the context of the EC-Thermie programme. Also, use has been made of a paper `Glass Manufacture, energy and CO{sub 2}-emissions`, presented by G.J. Copley of the British Glass Manufacturers Confederation, Sheffield, United Kingdom, presented at the Thermie Seminar in Wiesbaden, 1992. A third source of information has been the data collected by the CPIV, the European Glass Manufacturers Federation on the present and future economic situation of the EC Glass Industry. (orig.)

Chromosomal insertion of the entire Escherichia coli lactose operon, into two strains of Pseudomonas, using a modified mini-Tn5 delivery system

DEFF Research Database (Denmark)

Hansen, L. H.; Sørensen, S. J.; Jensen, Lars Bogø

1997-01-01

A 12-kb PstI fragment including the entire E. coli lactose operon (lacIPOZYA) was inserted in one copy into the chromosome of Pseudomonas putida, Pseudomonas fluorescens and an E. coli strain with lac(-) phenotype. This was made possible by improvements of an already existing mini-Tn5 transposon...... flanked by NotI sites needed in the mini-Tn5 delivery system; (b) the generation of E. coli nonlysogenic strains expressing the pi protein thus being capable of maintaining and delivering R6K-based mini-Tn5 vectors to other E. coli strains; (c) the successful insertion of the E. coli lactose operon...... into the P. fluorescens chromosome giving P. fluorescens the ability to grow on lactose; (d) evidence from Southern blotting that contradicts the assumption that the mini-Tn5 delivery system always creates one-copy inserts. These improvements allow insertion of large DNA fragments encoding highly expressed...

Canada files WTO complaint against EC.

Science.gov (United States)

2000-01-01

In December 1998, Canada filed a complaint alleging that the European Communities (EC) had adopted regulations that amounted to a scheme to extend patent terms, limited to pharmaceutical and agricultural chemical products.

NASA FACTS: E. coli AntiMicrobial Satellite (EcAMSat)

Science.gov (United States)

Spremo, Stevan; Cappuccio, Gelsomina; Tomko, David

2013-01-01

The E. coli AntiMicrobial Satellite(EcAMSat) mission will investigate space microgravity affects on the antibiotic resistance of E. coli, a bacterial pathogen responsible for urinary tract infection in humans and animals. EcAMSat is being developed through a partnership between NASAs Ames Research Center and the Stanford University School of Medicine. Dr. A.C. Matin is the Stanford University Principal Investigator. EcAMSat will investigate spaceflight effects on bacterial antibiotic resistance and its genetic basis. Bacterial antibiotic resistance may pose a danger to astronauts in microgravity, where the immune response is weakened. Scientists believe that the results of this experiment could help design effective countermeasures to protect astronauts health during long duration human space missions.

Accelerator-Driven Systems - the iThEC strategy

International Nuclear Information System (INIS)

Revol, Jean-Pierre

2015-01-01

The International Thorium Energy Committee (iThEC) created in Geneva in 2012 is concerned about the energetic future of our society, which is totally organized on the basis of a fossil fuel economy. This has to change because of obvious geopolitical reasons, because of the impact this economy has on the environment, and because of the rather short time on the human time scale, it will take for fossil fuels to run out. One of the main goals of iThEC is to work on reversing the current negative perception of nuclear energy in Europe, which is the main hurdle to a more serious R and D effort in this field. iThEC provides better information to the public on thorium possibilities, supports thorium ADS technology developments, any R and D regarding thorium, and actively engages the scientific, political and business leadership on the subject

Newton shows the light: a commentary on Newton (1672) ‘A letter … containing his new theory about light and colours…’

Science.gov (United States)

Fara, Patricia

2015-01-01

Isaac Newton's reputation was initially established by his 1672 paper on the refraction of light through a prism; this is now seen as a ground-breaking account and the foundation of modern optics. In it, he claimed to refute Cartesian ideas of light modification by definitively demonstrating that the refrangibility of a ray is linked to its colour, hence arguing that colour is an intrinsic property of light and does not arise from passing through a medium. Newton's later significance as a world-famous scientific genius and the apparent confirmation of his experimental results have tended to obscure the realities of his reception at the time. This paper explores the rhetorical strategies Newton deployed to convince his audience that his conclusions were certain and unchallengeable. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society. PMID:25750143

Un capítulo de la historia de las ideas sintácticas en Portugal: en torno a la teoría sintáctica del Ars grammaticae pro lingua lusitana addiscenda (Lyon, 1672 de Bento Pereira (S. I A Chapter in the History of Syntactic Ideas in Portugal: On the Syntactic Theory of Ars grammaticae pro lingua lusitana addiscenda (Lyon 1672 by Bento Pereira (S.I

Directory of Open Access Journals (Sweden)

Rogelio Ponce de León Romeo

2006-06-01

Full Text Available En este estudio se analizan los presupuestos sintácticos del Ars grammaticae pro lingua lusitana addiscenda (Lyon, 1672 del jesuita portugués Bento Pereira. En primer lugar se reflexiona sobre el papel de la sintaxis en las artes gramaticales impresas durante los siglos XVI y XVII, no sólo portuguesas o castellanas, sino también latinas; a continuación, se pasa a estudiar las características principales de la gramática de Bento Pereira, encuadrándola adecuadamente en el contexto gramaticográfico de su tiempo. Por lo que se refiere a la sintaxis propiamente dicha, se estudia el enfoque del jesuita portugués sobre las relaciones entre los constituyentes, así como la descripción que propone de las cláusulas subordinadas. Finalmente, se analizan someramente las fuentes de las que se sirve Bento Pereira.This paper discusses the syntactic premises of Ars grammaticae pro lingua lusitana addiscenda (Lyon 1672 by Portuguese Jesuit Bento Pereira. First, the role of syntax during the 16th and 17th C. not only in Portuguese and Spanish, but also in Latin printed grammatical arts is discussed. Then, the main characteristics of Bento Pereira´s grammar are accurately presented within the grammatographic context of his time. As regards syntax proper, the Portuguese Jesuist´s approach concerning the relationships between constituents, as well as the description he proposes for subordinate clauses are discussed. Finally, a brief review of Bento Pereira´s sources is presented.

Effect of Dursban 480 EC (chlorpyrifos) and Talstar 10 EC (bifenthrin) on the physiological and genetic diversity of microorganisms in soil.

Science.gov (United States)

Medo, Juraj; Maková, Jana; Kovácsová, Silvia; Majerčíková, Kamila; Javoreková, Soňa

2015-01-01

This investigation was undertaken to determine the impact of the insecticides Dursban 480 EC (with organophosphate compound chlorpyrifos as the active ingredient) and Talstar 10 EC (with pyrethroid bifenthrin as the active ingredient) on the respiration activity and microbial diversity in a sandy loam luvisol soil. The insecticides were applied in two doses: the maximum recommended dose for field application (15 mg kg(-1) for Dursban 480 EC and 6 mg kg(-1) for Talstar 10 EC) and a 100-fold higher dose for extrapolation of their effect. Bacterial and fungal genetic diversity was analysed in soil samples using PCR DGGE and the functional diversity (catabolic potential) was studied using BIOLOG EcoPlates at 1, 3, 7, 14, 28, 56 and 112 days after insecticide application. Five bacterial groups (α, β, γ proteobacteria, firmibacteria and actinomycetes) and five groups of fungi or fungus-like microorganisms (Ascomycota, Basidiomycota, Chytridiomycota, Oomycota and Zygomycota) were analysed using specific primer sets. This approach provides high resolution of the analysis covering majority of microorganisms in the soil. Only the high-dose Dursban 480 EC significantly changed the community of microorganisms. We observed its negative effect on α- and γ-proteobacteria, as the number of OTUs (operational taxonomic units) decreased until the end of incubation. In the β-proteobacteria group, initial increase of OTUs was followed by strong decrease. Diversity in the firmibacteria, actinomycetes and Zygomycota groups was minimally disturbed by the insecticide application. Dursban 480 EC, however, both positively and negatively affected certain species. Among negatively affected species Sphingomonas, Flavobacterium or Penicillium were detected, but Achromobacter, Luteibacter or Aspergillus were supported by applied insecticide. The analysis of BIOLOG plates using AWCD values indicated a significant increase in metabolic potential of microorganisms in the soil after the high

Nuclear power in the EC

International Nuclear Information System (INIS)

Charrault, J.C.

1991-01-01

Nuclear power accounts for some 35% of electricity production in the European Community (EC). Using a mathematical analysis, based on different scenarios, i.e. low/high electricity demand and nuclear moratorium/revival, various demand forecasts are made. A pragmatic approach, considering conventional power generation pollution problems, forecasts a revival of nuclear power

Mathematical modeling improves EC50 estimations from classical dose-response curves.

Science.gov (United States)

Nyman, Elin; Lindgren, Isa; Lövfors, William; Lundengård, Karin; Cervin, Ida; Sjöström, Theresia Arbring; Altimiras, Jordi; Cedersund, Gunnar

2015-03-01

The β-adrenergic response is impaired in failing hearts. When studying β-adrenergic function in vitro, the half-maximal effective concentration (EC50 ) is an important measure of ligand response. We previously measured the in vitro contraction force response of chicken heart tissue to increasing concentrations of adrenaline, and observed a decreasing response at high concentrations. The classical interpretation of such data is to assume a maximal response before the decrease, and to fit a sigmoid curve to the remaining data to determine EC50 . Instead, we have applied a mathematical modeling approach to interpret the full dose-response curve in a new way. The developed model predicts a non-steady-state caused by a short resting time between increased concentrations of agonist, which affect the dose-response characterization. Therefore, an improved estimate of EC50 may be calculated using steady-state simulations of the model. The model-based estimation of EC50 is further refined using additional time-resolved data to decrease the uncertainty of the prediction. The resulting model-based EC50 (180-525 nm) is higher than the classically interpreted EC50 (46-191 nm). Mathematical modeling thus makes it possible to re-interpret previously obtained datasets, and to make accurate estimates of EC50 even when steady-state measurements are not experimentally feasible. The mathematical models described here have been submitted to the JWS Online Cellular Systems Modelling Database, and may be accessed at http://jjj.bio.vu.nl/database/nyman. © 2015 FEBS.

ST ECS error handling and detector safety

CERN Document Server

Esperante Pereira, D

2010-01-01

This note describes the automatic operation sequences that the ECS implements in order to operate the ST detector in a safe and reliable way. First, the start-up sequences to set the detector in a well known state are described. In addition the possible ST detector states based on the status of the different detector elements will be defined. The states are of crucial interest for the safe operation of the detector when the LHC beam is ready. Besides, the ECS automatic actions taken in case of abnormal status of any of the detector elements are reported. Next, the operational alarm ranges and the error recovery mechanisms are mentioned.

EC Transmission Line Risk Identification and Analysis

Energy Technology Data Exchange (ETDEWEB)

Bigelow, Tim S [ORNL

2012-04-01

The purpose of this document is to assist in evaluating and planning for the cost, schedule, and technical project risks associated with the delivery and operation of the EC (Electron cyclotron) transmission line system. In general, the major risks that are anticipated to be encountered during the project delivery phase associated with the implementation of the Procurement Arrangement for the EC transmission line system are associated with: (1) Undefined or changing requirements (e.g., functional or regulatory requirements) (2) Underperformance of prototype, first unit, or production components during testing (3) Unavailability of qualified vendors for critical components Technical risks associated with the design and operation of the system are also identified.

EcPV2 DNA in equine genital squamous cell carcinomas and normal genital mucosa.

Science.gov (United States)

Bogaert, Lies; Willemsen, Anouk; Vanderstraeten, Eva; Bracho, Maria A; De Baere, Cindy; Bravo, Ignacio G; Martens, Ann

2012-07-06

Squamous cell carcinoma (SCC) represents the most common genital malignant tumor in horses. Similar to humans, papillomaviruses (PVs) have been proposed as etiological agents and recently Equine papillomavirus type 2 (EcPV2) has been identified in a subset of genital SCCs. The goals of this study were (1) to determine the prevalence of EcPV2 DNA in tissue samples from equine genital SCCs, penile intraepithelial neoplasia (PIN) and penile papillomas, using EcPV2-specific PCR, (2) to examine the prevalence of latent EcPV2 infection in healthy genital mucosa and (3) to determine genetic variability within EcPV2 and to disentangle phylogenetic relationships of EcPV2 among PVs. EcPV2 DNA was detected in all but one penile SCC (15/16), in all PIN lesions (8/8) and penile papillomas (4/4). Additionally, EcPV2 DNA was demonstrated in one of two metastasized lymph nodes, one contact metastasis in the mouth, two vaginal and one anal lesion. In healthy horses, EcPV2 DNA was detected in 10% (4/39) of penile swabs but in none of vulvovaginal swabs (0/20). This study confirms the presence of EcPV2 DNA in equine genital SCCs and shows its involvement in anal lesions, a lymph node and contact metastases. Latent EcPV2 presence was also shown in normal male genital mucosa. We found that different EcPV2 variants cocirculate among horses and that EcPV2 is related to the Delta+Zeta PVs and is only a very distant relative of high-risk human PVs causing genital cancer. Thus, similar viral tropism and similar malignant outcome of the infection do not imply close evolutionary relationship. Copyright © 2012 Elsevier B.V. All rights reserved.

The EC6 - an enhanced mid-sized reactor with fuel cycle applications

International Nuclear Information System (INIS)

Soulard, M.; Yu, S.; Hopwood, J.; Hastings, I.J.

2011-01-01

Atomic Energy of Canada Limited (AECL) has two CANDU reactor products matched to markets: the Enhanced CANDU 6 (EC6), a modern 700 MWe-class design, and the Advanced CANDU Reactor (ACR-1000), a 1200 MWe-class Gen III+ design. Both reactor types are designed to meet both market-, and customer-driven needs; the ACR-1000 design is 90% complete and market-ready. The EC6 incorporates the CANDU 6's well-proven features, and adds enhancements that make the reactor even safer and easier to operate. The EC6 is the only mid-sized reactor with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. The EC6 has domestic and offshore market pull and is the current focus of AECL's development program; market interest in the ACR-1000 is anticipated in the longer term. Some of the key features incorporated into the EC6 include upgrading containment and seismic capability to meet modern standards, shortening the overall project schedule, addressing obsolescence issues, optimizing maintenance outages and incorporating lessons learnt through feedback obtained from the operating plants. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. The first deployment of the EC6 is anticipated in Canada; off-shore markets are also being pursued. The EC6 burns natural uranium as standard. But, high neutron economy, on-power refuelling, a simple fuel bundle, and the fundamental CANDU fuel channel design provide the EC6 with the flexibility to accommodate a range of advanced fuels. (author)

ICECAP: an integrated, general-purpose, automation-assisted IC50/EC50 assay platform.

Science.gov (United States)

Li, Ming; Chou, Judy; King, Kristopher W; Jing, Jing; Wei, Dong; Yang, Liyu

2015-02-01

IC50 and EC50 values are commonly used to evaluate drug potency. Mass spectrometry (MS)-centric bioanalytical and biomarker labs are now conducting IC50/EC50 assays, which, if done manually, are tedious and error-prone. Existing bioanalytical sample preparation automation systems cannot meet IC50/EC50 assay throughput demand. A general-purpose, automation-assisted IC50/EC50 assay platform was developed to automate the calculations of spiking solutions and the matrix solutions preparation scheme, the actual spiking and matrix solutions preparations, as well as the flexible sample extraction procedures after incubation. In addition, the platform also automates the data extraction, nonlinear regression curve fitting, computation of IC50/EC50 values, graphing, and reporting. The automation-assisted IC50/EC50 assay platform can process the whole class of assays of varying assay conditions. In each run, the system can handle up to 32 compounds and up to 10 concentration levels per compound, and it greatly improves IC50/EC50 assay experimental productivity and data processing efficiency. © 2014 Society for Laboratory Automation and Screening.

Design analysis report for the TN-WHC cask and transportation system

Energy Technology Data Exchange (ETDEWEB)

Brisbin, S.A., Fluor Daniel Hanford

1997-02-13

This document presents the evaluation of the Spent Nuclear Fuel Cask and Transportation System. The system design was developed by Transnuclear, Inc. and its team members NAC International, Nelson Manufacturing, Precision Components Corporation, and Numatec, Inc. The cask is designated the TN-WHC cask. This report describes the design features and presents preliminary analyses performed to size critical dimensions of the system while meeting the requirements of the performance specification.

Lymphocyte adhesion to endothelial cell (EC) is stimulated by phorbol esters

International Nuclear Information System (INIS)

Haskard, D.; Cavender, D.; Ziff, M.

1986-01-01

The effect of phorbol esters on T cell adhesion to EC has been studied. The phorbol esters 12-0-tetradecanoyl-phorbol-13-acetate and 4-beta-phorbol-12-13-dibutyrate, but not the biologically inert 4-0-methyl-phorbol-12-13-didecanoate strongly increased the binding of 51 Cr-labeled T cells to human umbilical vein EC monolayers in microtiter wells. Increase in binding was observed at 0.3 ng/ml with maximal enhancement at 50 ng/ml. Both unstimulated and phorbol ester activated T cells displayed a substantially greater binding affinity for EC than for fibroblasts or plastic. Binding enhancement occurred within one minute, with maximal increase after 15 min. Preincubation studies showed that binding enhancement was entirely attributable to an effect on T cells, with no action on EC. Additive binding enhancement was seen when phorbol esters and reagents that increase adhesion by actions on EC (LPS, IL-1 and IFN-γ) were used together. Increase in adhesion of activated T lymphocytes to EC may explain the greater emigration of activated T cells than small resting T cells into inflammatory foci in vivo. The rapid onset of the phorbol effect suggests that this may be an important mechanism for immediate localization of circulating T cells in the cellular immune response, activated, perhaps, at the endothelial blood-tissue interface

On the practical exploitability of dual EC in TLS implementations

NARCIS (Netherlands)

Checkoway, S.; Fredrikson, M.; Niederhagen, R.F.; Everspaugh, A.; Green, M.; Lange, T.; Ristenpart, T.; Bernstein, D.J.; Maskiewicz, J,; Shacham, H.

2014-01-01

This paper analyzes the actual cost of attacking TLS implementations that use NIST’s Dual EC pseudorandom number generator, assuming that the attacker generated the constants used in Dual EC. It has been known for several years that an attacker generating these constants and seeing a long enough

EC6 safety enhancement - including impact of Fukushima lessons learned

Energy Technology Data Exchange (ETDEWEB)

Yu, S.; Zemdegs, R.; Boyle, S.; Soulard, M., E-mail: stephen.yu@candu.com [Candu Energy Inc., Mississauga, Ontario (Canada)

2012-09-15

The Enhanced CANDU 6 (EC6) is the new Generation III CANDU reactor design that meets the most up to date regulatory requirements and customer expectations. EC6 builds on the proven high performance design inch as the Qinshan CANDU 6 units and has made improvements to safety and operational performance, and has incorporated extensive operational feedback including Fukushima. The Fukushima Dai-ichi March 11, 2011 event has demonstrated the importance of defence-in-depth considerations for beyond-design basis events, including severe accidents. The EC6 design is based on the defence-in-depth principles and provides further design features that address the lessons learned from Fukushima. (author)

Enhanced nitrogen removal from piggery wastewater with high NH4+ and low COD/TN ratio in a novel upflow microaerobic biofilm reactor.

Science.gov (United States)

Meng, Jia; Li, Jiuling; Li, Jianzheng; Antwi, Philip; Deng, Kaiwen; Nan, Jun; Xu, Pianpian

2018-02-01

To enhance nutrient removal more cost-efficiently in microaerobic process treating piggery wastewater characterized by high ammonium (NH 4 + -N) and low chemical oxygen demand (COD) to total nitrogen (TN) ratio, a novel upflow microaerobic biofilm reactor (UMBR) was constructed and the efficiency in nutrient removal was evaluated with various influent COD/TN ratios and reflux ratios. The results showed that the biofilm on the carriers had increased the biomass in the UMBR and enhanced the enrichment of slow-growth-rate bacteria such as nitrifiers, denitrifiers and anammox bacteria. The packed bed allowed the microaerobic biofilm process perform well at a low reflux ratio of 35 with a NH 4 + -N and TN removal as high as 93.1% and 89.9%, respectively. Compared with the previously developed upflow microaerobic sludge reactor, the UMBR had not changed the dominant anammox approach to nitrogen removal, but was more cost-efficiently in treating organic wastewater with high NH 4 + -N and low COD/TN ratio. Copyright © 2017 Elsevier Ltd. All rights reserved.

A spectroscopic survey of EC4, an extended cluster in Andromeda's halo

Science.gov (United States)

Collins, M. L. M.; Chapman, S. C.; Irwin, M.; Ibata, R.; Martin, N. F.; Ferguson, A. M. N.; Huxor, A.; Lewis, G. F.; Mackey, A. D.; McConnachie, A. W.; Tanvir, N.

2009-07-01

We present a spectroscopic survey of candidate red giant branch stars in the extended star cluster, EC4, discovered in the halo of M31 from our Canada-France-Hawaii Telescope/MegaCam survey, overlapping the tidal streams, Streams`Cp' and `Cr'. These observations used the DEep Imaging Multi-Object Spectrograph mounted on the Keck II telescope to obtain spectra around the CaII triplet region with ~1.3 Å resolution. Six stars lying on the red giant branch within two core radii of the centre of EC4 are found to have an average vr = -287.9+1.9-2.4kms-1 and σv,corr = 2.7+4.2-2.7kms-1, taking instrumental errors into account. The resulting mass-to-light ratio for EC4 is M/L = 6.7+15-6.7Msolar/Lsolar, a value that is consistent with a globular cluster within the 1σ errors we derive. From the summed spectra of our member stars, we find EC4 to be metal-poor, with [Fe/H] = -1.6 +/- 0.15. We discuss several formation and evolution scenarios which could account for our kinematic and metallicity constraints on EC4, and conclude that EC4 is most comparable with an extended globular cluster. We also compare the kinematics and metallicity of EC4 with Streams `Cp' and`Cr', and find that EC4 bears a striking resemblance to Stream`Cp' in terms of velocity, and that the two structures are identical in terms of both their spectroscopic and photometric metallicities. From this, we conclude that EC4 is likely related to Stream`Cp'. The data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation. E-mail: mlmc2@ast.cam.ac.uk

Acute toxicity of heavy metals to acetate-utilizing mixed cultures of sulfate-reducing bacteria: EC100 and EC50.

Science.gov (United States)

Utgikar, V P; Chen, B Y; Chaudhary, N; Tabak, H H; Haines, J R; Govind, R

2001-12-01

Acid mine drainage from abandoned mines and acid mine pit lakes is an important environmental concern and usually contains appreciable concentrations of heavy metals. Because sulfate-reducing bacteria (SRB) are involved in the treatment of acid mine drainage, knowledge of acute metal toxicity levels for SRB is essential for the proper functioning of the treatment system for acid mine drainage. Quantification of heavy metal toxicity to mixed cultures of SRB is complicated by the confounding effects of metal hydroxide and sulfide precipitation, biosorption, and complexation with the constituents of the reaction matrix. The objective of this paper was to demonstrate that measurements of dissolved metal concentrations could be used to determine the toxicity parameters for mixed cultures of sulfate-reducing bacteria. The effective concentration, 100% (EC100), the lowest initial dissolved metal concentrations at which no sulfate reduction is observed, and the effective concentration, 50% (EC50), the initial dissolved metal concentrations resulting in a 50% decrease in sulfate reduction, for copper and zinc were determined in the present study by means of nondestructive, rapid physical and chemical analytical techniques. The reaction medium used in the experiments was designed specifically (in terms of pH and chemical composition) to provide the nutrients necessary for the sulfidogenic activity of the SRB and to preclude chemical precipitation of the metals under investigation. The toxicity-mitigating effects of biosorption of dissolved metals were also quantified. Anaerobic Hungate tubes were set up (at least in triplicate) and monitored for sulfate-reduction activity. The onset of SRB activity was detected by the blackening of the reaction mixture because of formation of insoluble ferrous sulfide. The EC100 values were found to be 12 mg/L for copper and 20 mg/L for zinc. The dissolved metal concentration measurements were effective as the indicators of the effect of the

EC environmental legislation and the European oil industry

International Nuclear Information System (INIS)

Luding, W.G.

1993-01-01

EUROPIA has 32 ordinary member companies which own and operate more than 95% of EC refining capacity, plus three associate member companies from EFTA countries. A large part of EUROPIA's efforts is devoted to environmental issues. Among its initial actions, EUROPIA developed Guiding Principles for environmental management which have been adopted by all member companies. This article can only highlight some of the key areas of EC environmental policy of interest to the oil industry. Most of the comments will refer to air pollution issues but, of course, water and ground pollution and waste are equally important subjects. (orig./HS)

Kinetic study on ligand exchange reaction between EC and 99mTc-GH

International Nuclear Information System (INIS)

Wu Chunying; Luo Shineng; Fang Ping; Huang Heyun; Xie Minhao; Meng Hong

1995-01-01

The ligand exchange reaction between EC and 99m Tc-GH and its influence factors such as concentrations of EC and pH were described. The concentration of EC has no influence on the exchange reaction rate constant, while pH is the most important influence factor. The rate constants of ligand exchange reaction at different pH values were determined. The results showed that in order to make the labelling yield of 99m Tc-EC higher than 90%, pH of the reaction must be higher than 8

Dynamic changes of serum TNF-α and cTnI levels in BALB/c Mouse models of autoimmune myocarditis

International Nuclear Information System (INIS)

Han Li'na

2007-01-01

Objective: To prepare mouse models of experimental autoimmune myocarditis (EAM) with subcutaneous injection of synthesized peptide (containing heavy chain segment of cardiac myosin) and examine the dynamic changes of cardiac pathology as well as TNF -α, cTnI and autoimmune antibody contents. Methods: BALB/c mice were subcutaneously injected with 0.8 mg of the synthesized peptide to produce the experimental autoimmune myocarditis (EAM) models. The animals were sacrificed 14, 21, 30 and 60d after establishment of the models, heart muscle was examined pathologically to assess the severity of myocarditis and blood were examined for the plasma contents of TNF-α (with RIA) cTnI (with ELISA) and anti-cardiac myosin heavy chain (CMHC) antibody titier (with ELISA). Results: Evidence of myocardial damage appeared on d14 specimens and progressed there after with interstitial infiltration of macrophages and myocardial necrosis. In the 60d specimens, fibrosis was obvious. The plasma TNF-α and cTnI levels were highest in the d30 specimens and declined in the d60 specimens but still remained much higher than normal. Most of the models demonstrated anti-CMHC antibodies in the 21d and 30d specimens. Conclusion: It is feasible to prepare EMC mouse models with subcutaneous injection of synthesized peptide containing heavy chain segment of cardiac myosin and the plasma levels of TNF-α, cTnI in the models are well correlated to the pathologic change of myocarditis. (authors)

Deposition of HgTe by electrochemical atomic layer epitaxy (EC-ALE)

CSIR Research Space (South Africa)

Venkatasamy, V

2006-04-01

Full Text Available This paper describes the first instance of HgTe growth by electrochemical atomic layer epitaxy (EC-ALE). EC-ALE is the electrochemical analog of atomic layer epitaxy (ALE) and atomic layer deposition (ALD), all of which are based on the growth...

Analysis of ATLAS FLB-EC6 Experiment using SPACE Code

International Nuclear Information System (INIS)

Lee, Donghyuk; Kim, Yohan; Kim, Seyun

2013-01-01

The new code is named SPACE(Safety and Performance Analysis Code for Nuclear Power Plant). As a part of code validation effort, simulation of ATLAS FLB(Feedwater Line Break) experiment using SPACE code has been performed. The FLB-EC6 experiment is economizer break of a main feedwater line. The calculated results using the SPACE code are compared with those from the experiment. The ATLAS FLB-EC6 experiment, which is economizer feedwater line break, was simulated using the SPACE code. The calculated results were compared with those from the experiment. The comparisons of break flow rate and steam generator water level show good agreement with the experiment. The SPACE code is capable of predicting physical phenomena occurring during ATLAS FLB-EC6 experiment

Association of Elevated High Sensitivity Cardiac Troponin T(hs-cTnT Levels with Hemorrhagic Transformation and 3-Month Mortality in Acute Ischemic Stroke Patients with Rheumatic Heart Disease in China.

Directory of Open Access Journals (Sweden)

Junfeng Liu

Full Text Available Elevated levels of high sensitivity cardiac troponin T (hs-cTnT occur in a substantial proportion of patients with acute ischemic stroke (AIS and can predict poor outcome and mortality after stroke. Whether elevated hs-cTnT levels can also predict hemorrhagic transformation (HT or prognosis in AIS patients with rheumatic heart disease (RHD remains unclear.Data from the Chengdu Stroke Registry on consecutive AIS patients with RHD admitted to West China Hospital within 1 month of stroke onset from October 2011 to February 2014 were examined. Clinico-demographic characteristics, HT, functional outcomes and stroke recurrence were compared between patients with elevated hs-cTnT levels (≥14 ng/L and patients with normal hs-cTnT levels (<14 ng/L.The final analysis involved 84 patients (31 males; mean age, 61.6±12.2 years, of whom serum hs-cTnT levels were elevated in 58.3%. Renal impairment was independently associated with elevated hs-cTnT levels (OR 4.184, 95%CI 1.17 to 15.01, P = 0.028, and patients with elevated hs-cTnT levels were at significantly higher risk of HT, 3-month mortality and 3-month disability/mortality (all P≤0.029. After controlling for age, sex, hypertension, renal impairment and National Institutes of Health Stroke Scale score on admission, the risk of HT and 3-month mortality was, respectively, 4.0- and 5.5-fold higher in patients with elevated hs-cTnT levels than in patients with normal hs-cTnT levels.Elevated hs-cTnT levels are independently associated with HT and 3-month mortality in AIS patients with RHD. These results with a small cohort should be verified and extended in large studies.

DOD Electronic Commerce (EC)/Electronic Data Interchange (EDI) in contracting report

Science.gov (United States)

1993-12-01

Use of Electronic Commerce (EC)/Electronic Data Interchange (EDI) to support Department of Defense (DoD) procurement processes has been under consideration for some time. A 1988 Deputy Secretary of Defense memo calls for maximum use of EDI, based on 10 years of DoD EDI investigation and experiments. In 1990, Defense Management Review Decision 941 stated, 'The strategic goal of DoD's current efforts is to provide the department with the capability to initiate, conduct, and maintain its external business related transactions and internal logistics, contracting, and financial activities without requiring the use of hard copy media.' The EC in Contracting PAT membership reflected a broad cross section of Military Services and Defense Agencies working on a full-time basis for 60 days. The diversity of the EC in Contracting PAT ensured that the needs and concerns of all DoD components were addressed during the creation of the report. The resultant plan, therefore, represents a comprehensive approach for implementing EC throughout the DoD.

Literary Depictions i n Ghazavâtnâmahs That Adress the Crimean War

Directory of Open Access Journals (Sweden)

Kürşat Şamil ŞAHİN

2015-07-01

Full Text Available The Crimean War that started in 1853 between the Ottoman Empire and Russia lasted until 1856. It ended with the defeat of the Russians as England and France sided with the Ottoman Empire. A great number of work has been written then and since about this war which deeply affect our social and politica l life. Among these, there are ghazavâtnâmahs that describe what happened down - to - line, usually by the pen of the poets and writers who closely witnessed the war. The causes of war, the preparations, what happened at the time of expedition and measures tha t were taken, the outcome of the events during the war and afterwards are all brought into sharp relief in most of these works. Whether in verse, prose or mixed typed, these works of art have gradually increased after 15 th century in Turkish literature. Th is genre has decreased by the Ottoman Empire began to decline and the raids were scarce; and it totally disappeared after the tradition of ghaza were ceased. In this study the literary depictions in - the last examples of the genre - Salih Hayri’s Kırım Zafe rnamesi (Hayrâbât, Ahmed Rızâ Trabzonî’s Manzume - i Sivastopol and Süleyman Şâdî’s Muzaffernâme are presented. There are not many studies that focus on literary depictions in ghazavâtnâmahs, particularly on literary war depictions. The characteristics of t hese literary depictions are tried to be explained with reference to ghazavâtnâmahs belonging to the Empire's last era.

ECS: Efficient Communication Scheduling for Underwater Sensor Networks

Directory of Open Access Journals (Sweden)

Lu Hong

2011-03-01

Full Text Available TDMA protocols have attracted a lot of attention for underwater acoustic sensor networks (UWSNs, because of the unique characteristics of acoustic signal propagation such as great energy consumption in transmission, long propagation delay and long communication range. Previous TDMA protocols all allocated transmission time to nodes based on discrete time slots. This paper proposes an efficient continuous time scheduling TDMA protocol (ECS for UWSNs, including the continuous time based and sender oriented conflict analysis model, the transmission moment allocation algorithm and the distributed topology maintenance algorithm. Simulation results confirm that ECS improves network throughput by 20% on average, compared to existing MAC protocols.

A global inventory of aircraft NO{sub x} emissions (ANCAT/EC 2). A revised inventory (1996) by the ECAC/ANCAT and EC working group

Energy Technology Data Exchange (ETDEWEB)

Gardner, R M [Great Minister House, London (United Kingdom). Dept. of Transfert London

1998-12-31

Results of the ANCAT/EC 2 inventory produced by the European ANCAT/EC emissions inventory group is reported. The base year inventory has been completed and is currently being written up for report publication. The ANCAT/EC 2 inventory in the base year, 1991/92, has accounted for a total fuel burn of 132.5 Tg/yr and a NO{sub x} mass of 1.82 Tg/yr. The civil subsonic fleet average emissions index is EI NO{sub x} 13.9. The inventory has accounted for 80% of the IEA refined jet fuel total for 1992. The forecast 2015 inventory accounts for 289.4 Tg/yr fuel and 3.48 Tg/yr NO{sub x}, increases of 118% and 91% respectively. Both datasets will be reported fully in the next few months. (author) 5 refs.

A global inventory of aircraft NO{sub x} emissions (ANCAT/EC 2). A revised inventory (1996) by the ECAC/ANCAT and EC working group

Energy Technology Data Exchange (ETDEWEB)

Gardner, R.M. [Great Minister House, London (United Kingdom). Dept. of Transfert London

1997-12-31

Results of the ANCAT/EC 2 inventory produced by the European ANCAT/EC emissions inventory group is reported. The base year inventory has been completed and is currently being written up for report publication. The ANCAT/EC 2 inventory in the base year, 1991/92, has accounted for a total fuel burn of 132.5 Tg/yr and a NO{sub x} mass of 1.82 Tg/yr. The civil subsonic fleet average emissions index is EI NO{sub x} 13.9. The inventory has accounted for 80% of the IEA refined jet fuel total for 1992. The forecast 2015 inventory accounts for 289.4 Tg/yr fuel and 3.48 Tg/yr NO{sub x}, increases of 118% and 91% respectively. Both datasets will be reported fully in the next few months. (author) 5 refs.

Efficient transformation of sucrose into high pullulan concentrations by Aureobasidium melanogenum TN1-2 isolated from a natural honey.

Science.gov (United States)

Jiang, Hong; Xue, Si-Jia; Li, Yan-Feng; Liu, Guang-Lei; Chi, Zhen-Ming; Hu, Zhong; Chi, Zhe

2018-08-15

A very high pullulan producing yeast-like fungus, Aureobasidium melanogenum TN1-2 isolated from a natural honey was found to be able to produce 97.0 g/L of pullulan from 140.0 g/L sucrose at a flask level while it could yield 114.0 g/L of pullulan within 134 h during a 10-liter fermentation, the yield was 0.81 g/g and the productivity was 0.86 g/L/h. The high ability to biosynthesize pullulan by this yeast-like fungal strain TN1-2 was related to high glucosyltransferase activity, high phosphofructo-2-kinase activity, high content of its cellular glycerol and low glucose repressor. The Mw of the produced pullulan was 1.42 × 10 5  g/mol. The low Mw may be due to the high α-amylase, glucoamylase and isopullulanase activities. The intracellular level of trehalose had no influence on high pullulan production by the yeast-like fungal strain TN1-2. Copyright © 2018. Published by Elsevier Ltd.

EC6 for Darlington - a managed-enhancements replication project

International Nuclear Information System (INIS)

Soulard, M.R.

2011-01-01

CANDU 6 design has a well-deserved reputation for lifetime performance and on-time, on-schedule construction. Candu Energy is finalizing development of an upgraded reactor product, the Enhanced CANDU 6 (EC6), which incorporates the CANDU 6's well-proven features, and adds enhancements that make the reactor even more safe and easier to operate. The EC6 is the only mid-sized reactor (700 MWe class) with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. Some of the key features incorporated into the EC6 include increasing the plant's power output, shortening the overall project schedule, addressing obsolescence issues, optimizing maintenance outages and incorporating lessons learnt through feedback obtained from the operating plants. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. An array of health monitoring equipment are also installed to foretell impending equipment problems, which can be acted upon, avoiding complications that could result in forced shutdowns. Improvements to the fire protection system and enhanced security features will further protect the assets. Containment and seismic capability are upgraded to meet modern standards. The first deployment of the EC6 is anticipated in Canada; other markets are also being pursued. The EC6 reactor is designed for a target lifetime capacity factor of 92% including 94% year-to-year and a 1% Forced Loss Rate. Since the number and duration of maintenance outages impact plant capacity factors, periodic short duration maintenance outages of less than a month once every 36 months is a key target of the EC6 reactor. This objective is achieved by automating a number of tasks such as shutdown systems testing. The majority

Translation and validation of the Dutch version of the Effective Consumer Scale (EC-17)

NARCIS (Netherlands)

ten Klooster, Peter M.; Taal, Erik; Tjin-Kam-Jet-Siemons, Liseth; Oostveen, J.C.M.; Oostveen, Johanna C.M.; Harmsen, Etelka J.; Tugwell, Peter S.; Rader, Tamara; Lyddiatt, Anne; van de Laar, Mart A F J

2013-01-01

PURPOSE: The Effective Consumer Scale (EC-17) measures the skills of musculoskeletal patients in managing their own healthcare. The objectives of this study were to translate the EC-17 into Dutch and to further evaluate its psychometric properties. METHODS: The EC-17 was translated and cognitively

The L‐type Ca2+ channel facilitates abnormal metabolic activity in the cTnI‐G203S mouse model of hypertrophic cardiomyopathy

Science.gov (United States)

Viola, Helena; Johnstone, Victoria; Cserne Szappanos, Henrietta; Richman, Tara; Tsoutsman, Tatiana; Filipovska, Aleksandra; Semsarian, Christopher

2016-01-01

Key points Genetic mutations in cardiac troponin I (cTnI) are associated with development of hypertrophic cardiomyopathy characterized by myocyte remodelling, disorganization of cytoskeletal proteins and altered energy metabolism.The L‐type Ca2+ channel is the main route for calcium influx and is crucial to cardiac excitation and contraction. The channel also regulates mitochondrial function in the heart by a functional communication between the channel and mitochondria via the cytoskeletal network.We find that L‐type Ca2+ channel kinetics are altered in cTnI‐G203S cardiac myocytes and that activation of the channel causes a significantly greater increase in mitochondrial membrane potential and metabolic activity in cTnI‐G203S cardiac myocytes.These responses occur as a result of impaired communication between the L‐type Ca2+ channel and cytoskeletal protein F‐actin, involving decreased movement of actin–myosin and block of the mitochondrial voltage‐dependent anion channel, resulting in a ‘hypermetabolic’ mitochondrial state.We propose that L‐type Ca2+ channel antagonists, such as diltiazem, might be effective in reducing the cardiomyopathy by normalizing mitochondrial metabolic activity. Abstract Genetic mutations in cardiac troponin I (cTnI) account for 5% of families with hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy is associated with disorganization of cytoskeletal proteins and altered energy metabolism. The L‐type Ca2+ channel (ICa‐L) plays an important role in regulating mitochondrial function. This involves a functional communication between the channel and mitochondria via the cytoskeletal network. We investigate the role of ICa‐L in regulating mitochondrial function in 25‐ to 30‐week‐old cardiomyopathic mice expressing the human disease‐causing mutation Gly203Ser in cTnI (cTnI‐G203S). The inactivation rate of ICa‐L is significantly faster in cTnI‐G203S myocytes [cTnI‐G203S: τ1 = 40.68 ± 3.22, n

The representation of tropical upper tropospheric water in EC Earth V2

Energy Technology Data Exchange (ETDEWEB)

Johnston, M.S. [Chalmers University of Technology, Department of Earth and Space Sciences, Goeteburg (Sweden); Swedish Meteorological and Hydrological Institute (SMHI), Norrkoeping (Sweden); Eriksson, P.; Murtagh, D.P. [Chalmers University of Technology, Department of Earth and Space Sciences, Goeteburg (Sweden); Eliasson, S. [Luleaa University of Technology, Department of Computer Science, Electrical and Space Engineering, Kiruna (Sweden); Jones, C.G. [Swedish Meteorological and Hydrological Institute (SMHI), Norrkoeping (Sweden); Forbes, R.M. [ECMWF, Reading, Berkshire (United Kingdom)

2012-12-15

Tropical upper tropospheric humidity, clouds, and ice water content, as well as outgoing longwave radiation (OLR), are evaluated in the climate model EC Earth with the aid of satellite retrievals. The Atmospheric Infrared Sounder and Microwave Limb Sounder together provide good coverage of relative humidity. EC Earth's relative humidity is in fair agreement with these observations. CloudSat and CALIPSO data are combined to provide cloud fractions estimates throughout the altitude region considered (500-100 hPa). EC Earth is found to overestimate the degree of cloud cover above 200 hPa and underestimate it below. Precipitating and non-precipitating EC Earth ice definitions are combined to form a complete ice water content. EC Earth's ice water content is below the uncertainty range of CloudSat above 250 hPa, but can be twice as high as CloudSat's estimate in the melting layer. CERES data show that the model underestimates the impact of clouds on OLR, on average with about 9 W m{sup -2}. Regionally, EC Earth's outgoing longwave radiation can be {proportional_to}20 W m{sup -2} higher than the observation. A comparison to ERA-Interim provides further perspectives on the model's performance. Limitations of the satellite observations are emphasised and their uncertainties are, throughout, considered in the analysis. Evaluating multiple model variables in parallel is a more ambitious approach than is customary. (orig.)

Egg cell-secreted EC1 triggers sperm cell activation during double fertilization.

Science.gov (United States)

Sprunck, Stefanie; Rademacher, Svenja; Vogler, Frank; Gheyselinck, Jacqueline; Grossniklaus, Ueli; Dresselhaus, Thomas

2012-11-23

Double fertilization is the defining characteristic of flowering plants. However, the molecular mechanisms regulating the fusion of one sperm with the egg and the second sperm with the central cell are largely unknown. We show that gamete interactions in Arabidopsis depend on small cysteine-rich EC1 (EGG CELL 1) proteins accumulating in storage vesicles of the egg cell. Upon sperm arrival, EC1-containing vesicles are exocytosed. The sperm endomembrane system responds to exogenously applied EC1 peptides by redistributing the potential gamete fusogen HAP2/GCS1 (HAPLESS 2/GENERATIVE CELL SPECIFIC 1) to the cell surface. Furthermore, fertilization studies with ec1 quintuple mutants show that successful male-female gamete interactions are necessary to prevent multiple-sperm cell delivery. Our findings provide evidence that mutual gamete activation, regulated exocytosis, and sperm plasma membrane modifications govern flowering plant gamete interactions.

EC4IT - A Guide to European Commission Projects for CERN/IT department

CERN Document Server

Jones, R

2012-01-01

European Commission (EC) projects represent an important source of external funding for a number of activities in which IT department is involved. The EC has a set of procedures and formalities for the preparation, negotiation, execution and completion of projects that are different to those normally used at CERN. This document gives an overview of the administrative, financial, reporting and managerial steps involved in participating in an EC project.

Application value of combined measurement of serum sTn, CA242, CA19-9 and CEA in the diagnosis of gastroenterological neoplasm

International Nuclear Information System (INIS)

Zhang Wanzhong; Chen Zhizhou; Fan Zhenfu

2007-01-01

To determine the application value of four serum tumor markers sTn, CA242, CA 19-9 and CEA in the diagnosis of gastroenterological neoplasm, the serum sTn, CA242, CA19-9 and CEA in 30 normal adult controls and 60 patients with gastroenterological neoplasm were measured by IRMA. The results showed that the serum sTn, CA242, CA19-9 and CEA levels in patients with gastric carcinoma or colorectal carcinoma were much higher than those in control group (P<0.01). The serum CEA, CA19-9 and CA242 levels in patients with colorectal carcinoma were significantly higher than those in patients with gastric carcinoma (P<0.01), but the serum sTn level in the former was markedly lower (P<0.01) than that in the latter. The sensitivity of tumor marker increased with the progress of clinical stages, with a considerably higher sensitivity for stage IV compared with stage I-II (P<0.01). The combined test of four tumor markers could be more sensitive than single test in detecting gastric carcinoma and colorectal carcinoma (P<0.05). Four tumor markers are useful for diagnosing gastroenterological neoplasm, and the combined measurement of 4 tumor markers could increase the sensitivity of detecting gastric carcinoma. (authors)

Present status of developing petroleum-substituting energy (EC)

Science.gov (United States)

1993-03-01

The EC has had approximately 50% of its total energy demand supplied by imports from the exterior of the Community. Hence, it is getting important to develop oil-substituting renewable energy as well as to curtail the emission of carbon dioxide. In consideration of these situations, the results of investigation on the energy policy of the European Community are described. The policy comprises three courses: European Energy Charter, formation of an open European Community energy market, and environmental conservation. Particularly, concerning the reduction of carbon dioxide emission, the EC Council has decided to introduce carbon dioxide taxation so as to suppress the carbon dioxide emission in the year 2000 to the 1990 level. The arrangement for its introduction, however, encountered with difficulties because of the opposition of various countries other than the European Community and the industrial world of the European Community. Legislation of the investment promotion law for energy saving and the construction of infrastructure footing and an information network are ineffective due to the sluggish fuel price and economic recession. A plurality of EC member countries are advancing a comprehensive activity within the framework of the joint programs of research, development, and demonstration set for the renewable energy policy ensuring energy supply and environmental harmonization.

Cooperative Fuzzy Games Approach to Setting Target Levels of ECs in Quality Function Deployment

Directory of Open Access Journals (Sweden)

Zhihui Yang

2014-01-01

Full Text Available Quality function deployment (QFD can provide a means of translating customer requirements (CRs into engineering characteristics (ECs for each stage of product development and production. The main objective of QFD-based product planning is to determine the target levels of ECs for a new product or service. QFD is a breakthrough tool which can effectively reduce the gap between CRs and a new product/service. Even though there are conflicts among some ECs, the objective of developing new product is to maximize the overall customer satisfaction. Therefore, there may be room for cooperation among ECs. A cooperative game framework combined with fuzzy set theory is developed to determine the target levels of the ECs in QFD. The key to develop the model is the formulation of the bargaining function. In the proposed methodology, the players are viewed as the membership functions of ECs to formulate the bargaining function. The solution for the proposed model is Pareto-optimal. An illustrated example is cited to demonstrate the application and performance of the proposed approach.

Cooperative fuzzy games approach to setting target levels of ECs in quality function deployment.

Science.gov (United States)

Yang, Zhihui; Chen, Yizeng; Yin, Yunqiang

2014-01-01

Quality function deployment (QFD) can provide a means of translating customer requirements (CRs) into engineering characteristics (ECs) for each stage of product development and production. The main objective of QFD-based product planning is to determine the target levels of ECs for a new product or service. QFD is a breakthrough tool which can effectively reduce the gap between CRs and a new product/service. Even though there are conflicts among some ECs, the objective of developing new product is to maximize the overall customer satisfaction. Therefore, there may be room for cooperation among ECs. A cooperative game framework combined with fuzzy set theory is developed to determine the target levels of the ECs in QFD. The key to develop the model is the formulation of the bargaining function. In the proposed methodology, the players are viewed as the membership functions of ECs to formulate the bargaining function. The solution for the proposed model is Pareto-optimal. An illustrated example is cited to demonstrate the application and performance of the proposed approach.

EC-LEDS Mexico: Advancing Clean Energy Goals

Energy Technology Data Exchange (ETDEWEB)

2016-07-01

EC-LEDS works with the government of Mexico to help meet its goals of reducing greenhouse gas emissions from the energy sector. The program targets specific, highly technical areas where Mexico has indicated the program can add value and make an impact.

EC-LEDS Supports the Low-Carbon Transition

Energy Technology Data Exchange (ETDEWEB)

2016-09-01

EC-LEDS is a flagship U.S. government-led effort that assists countries to create and implement low emission development strategies, or LEDS -- development frameworks that promote sustainable social and economic development while reducing greenhouse gas emissions over the medium to long term.

Overview of the ITER EC H and CD system and its capabilities

Energy Technology Data Exchange (ETDEWEB)

Omori, T., E-mail: toshimichi.omori@iter.org [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Henderson, M.A. [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Albajar, F. [Fusion for Energy, C/Josep Pla 2, Torres Diagonal Litoral-B3, E-08019 Barcelona (Spain); Alberti, S. [CRPP-Association EURATOM-Confederation Suisse, EPFL Ecublens, CH-1015 Lausanne (Switzerland); Baruah, U. [Institute for Plasma Research, Near Indira Bridge, Bhat, Gandhinagar 382428 (India); Bigelow, T.S. [US ITER Project Office, ORNL, 055 Commerce Park, PO Box 2008, Oak Ridge, TN 37831 (United States); Beckett, B. [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Bertizzolo, R. [CRPP-Association EURATOM-Confederation Suisse, EPFL Ecublens, CH-1015 Lausanne (Switzerland); Bonicelli, T. [Fusion for Energy, C/Josep Pla 2, Torres Diagonal Litoral-B3, E-08019 Barcelona (Spain); Bruschi, A. [Istituto di Fisica del Plasma, Association EURATOM-ENEA-CNR, Milano (Italy); Caughman, J.B. [US ITER Project Office, ORNL, 055 Commerce Park, PO Box 2008, Oak Ridge, TN 37831 (United States); Chavan, R. [CRPP-Association EURATOM-Confederation Suisse, EPFL Ecublens, CH-1015 Lausanne (Switzerland); Cirant, S. [Istituto di Fisica del Plasma, Association EURATOM-ENEA-CNR, Milano (Italy); Collazos, A. [CRPP-Association EURATOM-Confederation Suisse, EPFL Ecublens, CH-1015 Lausanne (Switzerland); Cox, D.; Darbos, C. [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France); Baar, M.R. de [Association EURATOM-FOM, 3430 BE Nieuwegein (Netherlands); Denisov, G. [Institute of Applied Physics, 46 Ulyanov Street, Nizhny Novgorod 603950 (Russian Federation); Farina, D. [Istituto di Fisica del Plasma, Association EURATOM-ENEA-CNR, Milano (Italy); Gandini, F. [ITER Organization, CS 90 046, 13067 St Paul Lez Durance Cedex (France)

2011-10-15

The Electron Cyclotron (EC) system for the ITER tokamak is designed to inject {>=}20 MW RF power into the plasma for Heating and Current Drive (H and CD) applications. The EC system consists of up to 26 gyrotrons (between 1 and 2 MW each), the associated power supplies, 24 transmission lines and 5 launchers. The EC system has a diverse range of applications including central heating and current drive, current profile tailoring and control of plasma magneto-hydrodynamic (MHD) instabilities such as the sawtooth and neoclassical tearing modes (NTMs). This diverse range of applications requires the launchers to be capable of depositing the EC power across nearly the entire plasma cross section. This is achieved by two types of antennas: an equatorial port launcher (capable of injecting up to 20 MW from the plasma axis to mid-radius) and four upper port launchers providing access from inside of mid radius to near the plasma edge. The equatorial launcher design is optimized for central heating, current drive and profile tailoring, while the upper launcher should provide a very focused and peaked current density profile to control the plasma instabilities. The overall EC system has been modified during the past 3 years taking into account the issues identified in the ITER design review from 2007 and 2008 as well as integrating new technologies. This paper will review the principal objectives of the EC system, modifications made during the past 2 years and how the design is compliant with the principal objectives.

Overview of the ITER EC H and CD system and its capabilities

International Nuclear Information System (INIS)

Omori, T.; Henderson, M.A.; Albajar, F.; Alberti, S.; Baruah, U.; Bigelow, T.S.; Beckett, B.; Bertizzolo, R.; Bonicelli, T.; Bruschi, A.; Caughman, J.B.; Chavan, R.; Cirant, S.; Collazos, A.; Cox, D.; Darbos, C.; Baar, M.R. de; Denisov, G.; Farina, D.; Gandini, F.

2011-01-01

The Electron Cyclotron (EC) system for the ITER tokamak is designed to inject ≥20 MW RF power into the plasma for Heating and Current Drive (H and CD) applications. The EC system consists of up to 26 gyrotrons (between 1 and 2 MW each), the associated power supplies, 24 transmission lines and 5 launchers. The EC system has a diverse range of applications including central heating and current drive, current profile tailoring and control of plasma magneto-hydrodynamic (MHD) instabilities such as the sawtooth and neoclassical tearing modes (NTMs). This diverse range of applications requires the launchers to be capable of depositing the EC power across nearly the entire plasma cross section. This is achieved by two types of antennas: an equatorial port launcher (capable of injecting up to 20 MW from the plasma axis to mid-radius) and four upper port launchers providing access from inside of mid radius to near the plasma edge. The equatorial launcher design is optimized for central heating, current drive and profile tailoring, while the upper launcher should provide a very focused and peaked current density profile to control the plasma instabilities. The overall EC system has been modified during the past 3 years taking into account the issues identified in the ITER design review from 2007 and 2008 as well as integrating new technologies. This paper will review the principal objectives of the EC system, modifications made during the past 2 years and how the design is compliant with the principal objectives.

Belle monte-carlo production on the Amazon EC2 cloud

International Nuclear Information System (INIS)

Sevior, Martin; Fifield, Tom; Katayama, Nobuhiko

2010-01-01

The Belle II experiment which aims to increase the Luminosity of the KEKB collider by a factor of 50 will search for physics beyond the Standard Model through precision measurements and the investigation of rare processes in Flavour physics. The expected data rate is comparable to a current era LHC experiment with commensurate computing needs. Incorporating commercial cloud computing, such as that provided by the Amazon Elastic Compute Cloud (EC2) into the Belle II computing model may provide a lower Total Cost of Ownership for the Belle II computing solution. To investigate this possibility, we have created a system to conduct the complete Belle Monte Carlo simulation chain on EC2 to benchmark the cost and performance of the service. This paper will describe how this was achieved in addition to the drawbacks and costs of large-scale Monte Carlo production on EC2.

Belle monte-carlo production on the Amazon EC2 cloud

Energy Technology Data Exchange (ETDEWEB)

Sevior, Martin; Fifield, Tom [University of Melbourne, School of Physics, Victoria 3010 Australia (Australia); Katayama, Nobuhiko, E-mail: msevior@gmail.co, E-mail: fifieldt@unimelb.edu.a, E-mail: nobu.katayama@kek.j [High Energy Accelerator Research Organisation (KEK), Tsukuba (Japan)

2010-04-01

The Belle II experiment which aims to increase the Luminosity of the KEKB collider by a factor of 50 will search for physics beyond the Standard Model through precision measurements and the investigation of rare processes in Flavour physics. The expected data rate is comparable to a current era LHC experiment with commensurate computing needs. Incorporating commercial cloud computing, such as that provided by the Amazon Elastic Compute Cloud (EC2) into the Belle II computing model may provide a lower Total Cost of Ownership for the Belle II computing solution. To investigate this possibility, we have created a system to conduct the complete Belle Monte Carlo simulation chain on EC2 to benchmark the cost and performance of the service. This paper will describe how this was achieved in addition to the drawbacks and costs of large-scale Monte Carlo production on EC2.

Genes and proteins of Escherichia coli (GenProtEc).

Science.gov (United States)

Riley, M; Space, D B

1996-01-01

GenProtEc is a database of Escherichia coli genes and their gene products, classified by type of function and physiological role and with citations to the literature for each. Also present are data on sequence similarities among E.coli proteins with PAM values, percent identity of amino acids, length of alignment and percent aligned. The database is available as a PKZip file by ftp from mbl.edu/pub/ecoli.exe. The program runs under MS-DOS on IMB-compatible machines. GenProtEc can also be accessed through the World Wide Web at URL http://mbl.edu/html/ecoli.html.

Permeation of Telone EC through protective gloves.

Science.gov (United States)

Zainal, Hanaa; Que Hee, Shane S

2005-09-30

Telone is a potent fumigant that is based on the chlorinated unsaturated hydrocarbon, 1,3-dichloropropene (1,3-DCP). It is often applied without dilution and so poses severe inhalation and air pollution threats. Urinary metabolites of 1,3-DCP have been detected after Telone skin exposure, so that preventing dermal exposure is also important. The objective of the study was to assess if nitrile and multi-layer ("laminated") gloves provide adequate protection against Telone EC formulation. To accomplish this, disposable (Safeskin) and chemically resistant (Sol-Vex) nitrile and laminated (Barrier mark and Silver Shield) glove materials were challenged by Telone EC with hexane liquid collection in an ASTM-type I-PTC-600 permeation cell. Analyses of cis- and trans-1,3-DCP in the collection fluid at specified times were performed on a moderately polar capillary column by gas chromatography-electron capture detection. Telone EC caused microholes in both nitrile materials, though the chemically protective material was degraded slower than the disposable nitrile. The laminated gloves offered limited protection. Silver Shield protected best because 1.5-2.3 mg 1,3-DCP permeated by 8 h relative to 2.5-7.6 mg for Barrier, implying about 2.5 times more protection for 8 h. Even for Silver Shield, the extent of protection was inadequate as illustrated by a risk assessment of the skin exposure situation. The normalized breakthrough times for both types of laminated gloves varied between 27 and 60 min. It is recommended that Viton gloves still be worn for protection.

Association of Elevated High Sensitivity Cardiac Troponin T(hs-cTnT) Levels with Hemorrhagic Transformation and 3-Month Mortality in Acute Ischemic Stroke Patients with Rheumatic Heart Disease in China.

Science.gov (United States)

Liu, Junfeng; Wang, Deren; Xiong, Yao; Liu, Bian; Hao, Zilong; Tao, Wendan; Liu, Ming

2016-01-01

Elevated levels of high sensitivity cardiac troponin T (hs-cTnT) occur in a substantial proportion of patients with acute ischemic stroke (AIS) and can predict poor outcome and mortality after stroke. Whether elevated hs-cTnT levels can also predict hemorrhagic transformation (HT) or prognosis in AIS patients with rheumatic heart disease (RHD) remains unclear. Data from the Chengdu Stroke Registry on consecutive AIS patients with RHD admitted to West China Hospital within 1 month of stroke onset from October 2011 to February 2014 were examined. Clinico-demographic characteristics, HT, functional outcomes and stroke recurrence were compared between patients with elevated hs-cTnT levels (≥14 ng/L) and patients with normal hs-cTnT levels (mortality and 3-month disability/mortality (all P≤0.029). After controlling for age, sex, hypertension, renal impairment and National Institutes of Health Stroke Scale score on admission, the risk of HT and 3-month mortality was, respectively, 4.0- and 5.5-fold higher in patients with elevated hs-cTnT levels than in patients with normal hs-cTnT levels. Elevated hs-cTnT levels are independently associated with HT and 3-month mortality in AIS patients with RHD. These results with a small cohort should be verified and extended in large studies.

77 FR 17408 - Foreign-Trade Zone 204-Tri-Cities Area, TN/VA; Application for Reorganization Under Alternative...

Science.gov (United States)

2012-03-26

... Technology Park, 4509 West Stone Drive, Kingsport, Hawkins County, TN; Site 9 (134 acres, expires 6/30/15.... The grantee's proposed service area under the ASF would be the Counties of Sullivan, Hawkins, Greene...

Dengue virus inactivation by minipool TnBP/Triton X-45 treatment of plasma and cryoprecipitate.

Science.gov (United States)

Burnouf, T; Chou, M-L; Cheng, L-H; Li, Z-R; Wu, Y-W; El-Ekiaby, M; Tsai, K-H

2013-01-01

A minipool solvent/detergent (S/D; 1% TnBP/1% Triton X-45; 31°C) process was developed for viral inactivation of plasma and cryoprecipitate used for transfusion. The goal of this study was to determine the rate and extent of inactivation of dengue virus (DENV) during this process. DENV-1 was propagated using C6/36 mosquito cells to an infectivity titre close to 9 log and spiked (10% v/v) into individual plasma and cryoprecipitate samples from two distinct donors. Samples were taken right after spiking and during viral inactivation treatment by 1% TnBP-1% Triton X-45 at 31°C. DENV-1 infectivity was assessed on Vero E6 cells by a focus-forming assay (FFA). Culture medium and complement-inactivated plasma were used as experimental controls. Experiments were done in duplicate. DENV-1 infectivity was 7·5 log in spiked plasma and 7·1 and 7·3 log in spiked cryoprecipitate. There was no loss of DENV-1 infectivity in the spiked materials, nor in the controls not subjected to S/D treatment. No infectivity was found in plasma and cryoprecipitate subjected to S/D treatment at the first time-point evaluated (10 min). DENV-1 was strongly inactivated in plasma and cryoprecipitate, respectively, within 10 min of 1% TnBP/1% Triton X-45 treatment at 31°C. These data provide a reassurance of the safety of such S/D-treated plasma and cryoprecipitate with regard to the risk of transmission of all DENV serotypes and other flaviviruses. © 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion.

On the almost everywhere convergence of the eigenfunction expansions from Liouville classes L_1^\\alpha ({T^N})

Science.gov (United States)

Ahmedov, Anvarjon; Materneh, Ehab; Zainuddin, Hishamuddin

2017-09-01

The relevance of waves in quantum mechanics naturally implies that the decomposition of arbitrary wave packets in terms of monochromatic waves plays an important role in applications of the theory. When eigenfunction expansions does not converge, then the expansions of the functions with certain smoothness should be considered. Such functions gained prominence primarily through their application in quantum mechanics. In this work we study the almost everywhere convergence of the eigenfunction expansions from Liouville classes L_p^α ({T^N}), related to the self-adjoint extension of the Laplace operator in torus TN . The sufficient conditions for summability is obtained using the modified Poisson formula. Isomorphism properties of the elliptic differential operators is applied in order to obtain estimation for the Fourier series of the functions from the classes of Liouville L_p^α .

Regulatory competences of the EC in the energy sector; Regelungszustaendigkeiten der EG im Bereich Energie

Energy Technology Data Exchange (ETDEWEB)

Baur, J.F.; Blask, H. [Koeln Univ. (Germany). Inst. fuer das Recht der Europaeischen Gemeinschaften und Inst. fuer Energierecht

2002-09-01

In the light of necessary amendments of the Internal Electricity Market Directive and the Internal Gas Market Directive, a debate has evolved within the European Community about lawmaking powers for the energy sector. Whereas the Member States refer to the EC Treaty and deny any lawmaking powers of the EC for the energy sector, the EC defends its position that the EC should have and can derive lawmaking competence for energy policy decisions from the EC Treaty. The author reviews the situation from the legal point of view based on existing provisions and gives an outlook on a possible outcome of the ''constitutional convention'' of the EC which is to meet for discussing a revision of the EC Treaty. (orig./CB) [German] In Bezug auf die geplanten Aenderungen der Binnenmarktrichtlinien fuer Elektrizitaet und Gas werden moegliche Kompetenzen der EG im Bereich der Energiepolitik und ihre Grenzen eroertert. In einer Schlussbetrachtung werden die Ergebnisse zusammengefasst und ein kurzer Ausblick auf die Arbeit des 'Verfassungskonvents' der EU und die anstehende Vertragsrevision geworfen, in deren Rahmen die Implikation einer eigenstaendigen Spezialkompetenz im Bereich Energie erneut thematisiert werden koennte. (orig./CB)

76 FR 53115 - Foreign-Trade Zone 77-Memphis, TN; Application for Temporary/Interim Manufacturing Authority...

Science.gov (United States)

2011-08-25

... Phone/Mobile Handset Kitting); Memphis, TN An application has been submitted to the Executive Secretary... authority to produce cell phones/mobile handsets kits (HTSUS 8517.12, HTSUS 8517.62, HTSUS 8517.69, duty... cell phone/mobile handset kits (duty free) for the foreign inputs noted above. In accordance with the...

The shift of energy regulatory powers under the framework of Directive 2009/72/EC

International Nuclear Information System (INIS)

Grimm, N. S.

2011-01-01

The paper examines the powers of Member States' national regulatory authorities under the framework of Directive 2009/72/EC of the European Parliament and of the Council of 13 July 2009 concerning common rules for the internal market in electricity and repealing Directive 2003/54/EC (OJEU L 176/37) and analyses the implications of framework of Directive 2009/72/EC on the national laws of the Member States, in particular on the Austrian and German constitutional, administrative and energy laws. The Introductory Part gives a historical overview of the development of national energy regulators under European energy legislation. This Part shows that the national regulatory authorities attract increased attention and that their regulatory powers are on a constant rise. In order to understand the huge impact of the framework of Directive 2009/72/EC on the regulatory regimes of the Member States, this Part briefly examines the former and current powers of the national energy regulators under Austrian and German law. Part Two analyses whether the powers conferred upon national energy regulators under the framework of Directive 2009/72/EC have been enhanced in comparison to those established under the framework of Directive 2003/54/EC. The main focus lies thereby on the propositions made by the European Commission in its Proposal for a Directive of the European Parliament and of the Council amending Directive 2003/54/EC concerning common rules for the internal market in electricity (COM (2007) 528 final, 2.1) and laid down in Directive 2009/72/EC. Part Two comes to the conclusion that the powers of the national energy regulators under the framework of Directive 2009/72/EC have indeed been enhanced in comparison to former regime of Directive 2003/54/EC. Part Three demonstrates that the enhancement of national energy regulators' powers does not benefit the Member States. On the contrary, they lose considerable powers of control over their own national energy regulators. While

The TN-RAM - a new cask for shipping high activity irradiated hardware

International Nuclear Information System (INIS)

Neider, T.; Hanson, A.S.

1993-01-01

Transnuclear, Inc. has developed a Type B(U) radioactive material transport packaging designed specifically for the transport of dry, irradiated, non-fuel bearing components (NFBC). The TN-RAM is a transport cask in the configuration of a right circular cylinder, fabricated from lead and stainless steel, with wood-filled impact limiters attached at both ends. The lead and stainless steel construction of the lid, walls, and bottom provides a shielding effectiveness of approximately 7.1 inches (18 cm) lead equivalent. (J.P.N.)

Pengaruh Tingkat EC (Electrical Conductivity terhadap Pertumbuhan Tanaman Sawi (Brassica juncea L. pada Sistem Instalasi Aeroponik Vertikal

Directory of Open Access Journals (Sweden)

Pusdima Rahma Pratiwi

2015-07-01

Full Text Available Kebutuhan akan tanaman sawi semakin meningkat, sehingga diperlukan teknologi yang dapat memaksimalkan hasil serta memperbaiki teknik budidaya, salah satunya teknik budidaya aeroponik vertikal. Penelitian ini bertujuan untuk mengetahui respon pertumbuhan tanaman sawi yang terbaik terhadap pengaruh tingkat EC pada larutan nutrisi. Penelitian ini dilaksanakan di daerah Bekasi Timur dengan ketinggian 25 m di atas permukaan laut, dimulai pada bulan April 2014 sampai Juli 2014. Rancangan yang digunakan adalah Rancangan Acak Kelompok dengan 4 perlakuan yaitu A (Tingkat EC 1 mS cm-1, B (Tingkat EC 1,5 mS cm-1, C (Tingkat EC 2 mS cm-1, dan D (Tingkat EC 2,5 mS cm-1 dengan diulang sebanyak 4 kali. Hasil penelitian menunjukkan bahwa tingkat EC berpengaruh terhadap tinggi tanaman sawi pada umur 14 dan 18 hst, luas daun pada umur 26 dan 30 hst, panjang akar pada umur 30 hst, dan bobot basah pada umur 30 hst. Tingkat EC 2,5 mS cm-1 memberikan pengaruh baik terhadap bobot basah. The increasing need of mustard require technologies that can maximize result and improve cultivation, one of them is aeroponic vertical cultivation technique. This research aimed to know the best response of mustard growth on influence of nutrient EC level. This research was carried out in Bekasi Timur with altitude of 25 m above sea level, form April 2014 to July 2014. The design used was Randomized Block Design with 4 treatments that A (EC level 1 mS cm-1, B (EC level 1,5 mS cm-1, C (EC level 2 mS cm-1, and D (EC level  2,5 mS cm-1 with 4 replications. The results showed that EC level affected on plant height at 14 and 18 dap, leaf area at 26 and 30 dap, root length at 30 dap, and wet weight at the age of 30 dap. The EC level 2,5 mS cm-1had better effect on wet weight.

HTR fuel research in the HTR-TN network on the high flux reactor

Energy Technology Data Exchange (ETDEWEB)

Guidez, J.; Conrad, R.; Sevini, P.; Burghartz, M. [HFR Unit, Institute for Advanced Materials, European Commission, Joint Research Centre, Petten (Netherlands); Languille, A. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Guillermier, P. [FRAMATOME ANP, 69 - Lyon (France); Bakker, K. [Nuclear Research and Consultancy Group, Petten (Netherlands); Nabielek, H. [Forschungszentrum Juelich (Germany)

2001-07-01

Foremost, this paper explains the economic and strategic reasons for the comeback of the HTR reactor as one of the most promising reactors in the future. To study all the points related to HTR technology, a European network called HTR-TN was created in April 2000, with actually twenty European companies involved. This paper explains the organisation of the network and the related task-groups. In the field of fuel, one of these task-groups works on the fuel cycle and another works on the fuel itself in order to validate by testing HTR fuel possibilities. To this aim, an experimental loop is under construction in the HFR reactor to test full-size pebble type fuel elements and another under study to test compact fuel possibilities. These loops are based on all the experience accumulated by the High Flux Reactor in the years 70-90, when a lot of test were performed for fuel and material for the HTR technology and the facility design uses all the existing HFR knowledge. In conclusion, a host of research work, co-ordinated in the frame of a European network HTR-TN has begun. and should allow in the near future a substantial progress in the knowledge of this very promising fuel. (author)

HTR fuel research in the HTR-TN network on the high flux reactor

International Nuclear Information System (INIS)

Guidez, J.; Conrad, R.; Sevini, P.; Burghartz, M.; Languille, A.; Guillermier, P.; Bakker, K.; Nabielek, H.

2001-01-01

Foremost, this paper explains the economic and strategic reasons for the comeback of the HTR reactor as one of the most promising reactors in the future. To study all the points related to HTR technology, a European network called HTR-TN was created in April 2000, with actually twenty European companies involved. This paper explains the organisation of the network and the related task-groups. In the field of fuel, one of these task-groups works on the fuel cycle and another works on the fuel itself in order to validate by testing HTR fuel possibilities. To this aim, an experimental loop is under construction in the HFR reactor to test full-size pebble type fuel elements and another under study to test compact fuel possibilities. These loops are based on all the experience accumulated by the High Flux Reactor in the years 70-90, when a lot of test were performed for fuel and material for the HTR technology and the facility design uses all the existing HFR knowledge. In conclusion, a host of research work, co-ordinated in the frame of a European network HTR-TN has begun. and should allow in the near future a substantial progress in the knowledge of this very promising fuel. (author)

A TALE of transposition: Tn3-like transposons play a major role in the spread of pathogenicity determinants of Xanthomonas citri and other xanthomonads.

Science.gov (United States)

Ferreira, Rafael Marini; de Oliveira, Amanda Carolina P; Moreira, Leandro M; Belasque, José; Gourbeyre, Edith; Siguier, Patricia; Ferro, Maria Inês T; Ferro, Jesus A; Chandler, Michael; Varani, Alessandro M

2015-02-17

Members of the genus Xanthomonas are among the most important phytopathogens. A key feature of Xanthomonas pathogenesis is the translocation of type III secretion system (T3SS) effector proteins (T3SEs) into the plant target cells via a T3SS. Several T3SEs and a murein lytic transglycosylase gene (mlt, required for citrus canker symptoms) are found associated with three transposition-related genes in Xanthomonas citri plasmid pXAC64. These are flanked by short inverted repeats (IRs). The region was identified as a transposon, TnXax1, with typical Tn3 family features, including a transposase and two recombination genes. Two 14-bp palindromic sequences within a 193-bp potential resolution site occur between the recombination genes. Additional derivatives carrying different T3SEs and other passenger genes occur in different Xanthomonas species. The T3SEs include transcription activator-like effectors (TALEs). Certain TALEs are flanked by the same IRs as found in TnXax1 to form mobile insertion cassettes (MICs), suggesting that they may be transmitted horizontally. A significant number of MICs carrying other passenger genes (including a number of TALE genes) were also identified, flanked by the same TnXax1 IRs and delimited by 5-bp target site duplications. We conclude that a large fraction of T3SEs, including individual TALEs and potential pathogenicity determinants, have spread by transposition and that TnXax1, which exhibits all of the essential characteristics of a functional transposon, may be involved in driving MIC transposition. We also propose that TALE genes may diversify by fork slippage during the replicative Tn3 family transposition. These mechanisms may play a crucial role in the emergence of Xanthomonas pathogenicity. Xanthomonas genomes carry many insertion sequences (IS) and transposons, which play an important role in their evolution and architecture. This study reveals a key relationship between transposons and pathogenicity determinants in

mcr-1 and blaKPC-3 in Escherichia coli Sequence Type 744 after Meropenem and Colistin Therapy, Portugal.

Science.gov (United States)

Tacão, Marta; Tavares, Rafael Dos Santos; Teixeira, Pedro; Roxo, Inês; Ramalheira, Elmano; Ferreira, Sónia; Henriques, Isabel

2017-08-01

Escherichia coli Ec36 was recovered from a patient in Portugal after treatment with meropenem and colistin. Besides an IncF plasmid with Tn1441d-bla KPC-3 , already reported in clinical strains in this country, E. coli Ec36 co-harbored an IncX4::mcr-1 gene. Results highlight emerging co-resistance to carbapenems and polymyxins after therapy with drugs from both classes.

Adaptation of the Emotional Contagion Scale (ECS and gender differences within the Greek cultural context

Directory of Open Access Journals (Sweden)

Damigos Dimitris

2008-08-01

Full Text Available Abstract Background The Emotional Contagion Scale (ECS is a self-report scale used to measure individual differences in susceptibility to converge towards the emotions expressed by others. The main aim of the present paper was to examine the psychometric properties of the Greek translation of the scale. Methods The Greek ECS was completed by 691 undergraduate students (312 males and 379 females. To investigate the factor structure of the ECS, principal components analysis (PCA was used. Results The results showed that a four-factor model was tenable. Regarding homogeneity, the Greek ECS version showed acceptable results for the full scale (α = 0.74 but not for all subscales. Gender differences were also identified concerning the susceptibility to emotional contagion between men and women. Women score significantly higher than men for all the different emotions described by the ECS (love, happiness, sadness except the anger emotion, where there was no significant difference. Conclusion The Greek version of the ECS showed good psychometric properties. It can be used to assess susceptibility to emotional contagion in correlation with psychopathological processes, mood and anxiety disorders primarily. The usefulness of the ECS in the fields of group psychotherapy and health psychology is also under consideration. Further investigation is needed in all these areas.

The upgrade of the DIII-D EC system using 120 GHz ITER gyrotrons

International Nuclear Information System (INIS)

Callis, R.W.; Lohr, J.; Gorelov, I.A.; Ponce, D.; Kajiwara, K.; Tooker, J.F.

2005-01-01

The planned growth in the EC system on DIII-D over the next few years requires the installation of two depressed collector gyrotrons, a high voltage power supply, two low loss transmission lines, and the required support equipment. This new DIII-D EC equipment could be made identical to the ITER EC system requirements. By building the DIII-D hardware to the ITER specifications, it will allow ITER to gain beneficial prototyping experience on a working tokamak, prior to committing to building the hardware for delivery to ITER

Revisiting the EC/CMB model for extragalactic large scale jets

Science.gov (United States)

Lucchini, M.; Tavecchio, F.; Ghisellini, G.

2017-04-01

One of the most outstanding results of the Chandra X-ray Observatory was the discovery that AGN jets are bright X-ray emitters on very large scales, up to hundreds of kpc. Of these, the powerful and beamed jets of flat-spectrum radio quasars are particularly interesting, as the X-ray emission cannot be explained by an extrapolation of the lower frequency synchrotron spectrum. Instead, the most common model invokes inverse Compton scattering of photons of the cosmic microwave background (EC/CMB) as the mechanism responsible for the high-energy emission. The EC/CMB model has recently come under criticism, particularly because it should predict a significant steady flux in the MeV-GeV band which has not been detected by the Fermi/LAT telescope for two of the best studied jets (PKS 0637-752 and 3C273). In this work, we revisit some aspects of the EC/CMB model and show that electron cooling plays an important part in shaping the spectrum. This can solve the overproduction of γ-rays by suppressing the high-energy end of the emitting particle population. Furthermore, we show that cooling in the EC/CMB model predicts a new class of extended jets that are bright in X-rays but silent in the radio and optical bands. These jets are more likely to lie at intermediate redshifts and would have been missed in all previous X-ray surveys due to selection effects.

Austria's environmental law in comparison with the environmental law of the EC

International Nuclear Information System (INIS)

Jantscher, S.H.

1991-11-01

The thesis describes and compares the environmental legislation in Austria and the EC. A short introduction into structure and organization of EC-institutions and EC-legislation in followed by an examination of the constitutional foundations of environmental policy in Austria and the EC respectively. After the adoption for the Single European Act, the EEC-Treaty provides for objectives, orientation criteria and instruments regarding environmental protection. These provisions constitute a valid basis for environmental action. The adoption of a constitutional law does equally declare environmental protection as an objective of the state in Austria, however, its significance is regarded as rather controversial. Some provinces ('Laender') have shown a higher degree of sensitivity in their constitutions . The distribution of powers between the EC and its member stated in the field of environmental protection is of particular interests. It is shown, that the principle of subsidiarity and the safeguard-clauses leave discretion to the member states. Much will be determined by the European Court of Justice (ECJ) . Main emphasis has been placed on the description and comparison of Austria's and the EEC-environmental legislation. Environmental legislation of Austria as well as the EC is outlined sector by sector (i.e. water, air, chemicals, waste, soil, fauna and flora) and subsequently the object of a detailed comparison. Criteria, such as - preventiveness -stringency - focus, depth and comprehensiveness - clearness and legal force of the regulations have been applied. For most of the mentioned sectors it is correct to state, that Austria's legislation is more preventive, advanced, comprehensive and stringent (especially regulations related to water, waste, chemicals, also air) . However, there are particular areas (e.g. air quality objectives, noise limits for construction plants) where Austria' s legislation may well get a fresh impetus

Effect of PCI on inflammatory factors, cTnI, MMP-9 and NT-pro BNP in patients with unstable angina pectoris

Directory of Open Access Journals (Sweden)

Ke-Tong Liu

2016-05-01

Full Text Available Objective: To investigate the effect of PCI on inflammatory factors, cTnI, MMP-9and NTpro BNP in patients with unstable angina pectoris. Methods: A total of 80 unstable angina pectoris patients were divided into observation group (40 cases and control group (40 cases. The observation group was given the therapy of PCI, and the control group was given coronary angiography. To observe the of inflammatory factors, cTnI, MMP-9 and NT-pro BNP were tested and compared before and after operation. Results: At 24 h after operation, CRP and IL-18 levels were increased significantly after treatment inoperation groups, there was no difference on inflammatory factors in control group, and had significant difference on inflammatory factors in two groups; At 24 h after operation, cTnI, MMP-9 and NT-pro BNP levels were increased significantly after treatment inoperation groups, there was no difference on inflammatory factors in control group, and had significant difference on inflammatory factors in two groups. Conclusion: PCI therapy can induce inflammation and myocardial injury in patients with unstable angina pectoris.

Demonstration of sawtooth period control with EC waves in KSTAR plasma

Directory of Open Access Journals (Sweden)

Jeong J. H.

2015-01-01

Full Text Available The sawtooth period control in tokamak is important issue in recent years because the sawtooth crash can trigger TM/NTM instabilities and drive plasmas unstable. The control of sawtooth period by the modification of local current profile near the q=1 surface using ECCD has been demonstrated in a number of tokamaks [1, 2] including KSTAR. As a result, developing techniques to control the sawtooth period as a way of controlling the onset of NTM has been an important area of research in recent years [3]. In 2012 KSTAR plasma campaign, the sawtooth period control is carried out by the different deposition position of EC waves across the q=1 surface. The sawtooth period is shortened by on-axis co-ECCD (destabilization, and the stabilization of the sawtooth is also observed by off-axis co-ECCD at outside q=1 surface. In 2013 KSTAR plasma campaign, the sawtooth locking experiment with periodic forcing of 170 GHz EC wave is carried out to control the sawtooth period. The optimal target position which lengthens the sawtooth period is investigated by performing a scan of EC beam deposition position nearby q=1 surface at the toroidal magnetic field of 2.9 T and plasma current of 0.7 MA. The sawtooth locking by the modulated EC beam is successfully demonstrated as in [3-5] with the scan of modulation-frequency and duty-ratio at the low beta (βN~0.5 plasma. In this paper, the sawteeth behavior by the location of EC beam and the preliminary result of the sawtooth locking experiments in KSTAR will be presented.

Process-engineering control valves under the EC codes; Steuerventile fuer die Prozesstechnik im Geltungsbereich der EG-Richtlinien

Energy Technology Data Exchange (ETDEWEB)

Gohlke, B. [IMI Norgren Herion Fluidtronic GmbH und Co. KG, Fellbach (Germany)

2003-09-01

The European Parliament and European Council have enacted special codes in order to implement uniform conditions in all countries of the European Community. The manufacturers of technical and commercial products are obliged to adhere to these codes. Harmonized standards, which are to be used as a tool for the implementation of the codes, are embedded at another level of the overall 'European reference literature'. Two EC codes, in particular, are definitive for fluids engineering: On the one hand, the EC Machinery Code, 98/37/EC and, on the other hand, the EC Pressurized Equipment Code, 97/23/EC. These EC codes cover, inter alia, machinery and chemical process-engineering plants, and conventional power generating plants. Norgren-Herion, a manufacturer of fluid engineering components, perceived a necessity for positioning its control valves in the scope of applicability of the EC codes. This article describes experience with the EC codes from the control valve manufacturer's point of view and examines the various qualification procedures for control valves. (orig.)

Genes and proteins of Escherichia coli K-12 (GenProtEC).

Science.gov (United States)

Riley, M

1997-01-01

GenProtEC is a database of Escherichia coli genes and their gene products, classified by type of function and physiological role and with citations to the literature for each. Also present are data on sequence similarities amongE.coliproteins with PAM values, percent identity of amino acids, length of alignment and percent aligned. GenProtEC can also be accessed through the World Wide Web at URL http://mbl.edu/html/ecoli.html .

76 FR 60802 - Foreign-Trade Zone 77-Memphis, TN; Withdrawal of Request for Temporary/Interim Manufacturing...

Science.gov (United States)

2011-09-30

..., Inc., (Cell Phone/Mobile Handset Kitting). Memphis, TN Notice is hereby given of the withdrawal of the application of the City of Memphis, grantee of FTZ 77, requesting temporary/interim manufacturing authority on behalf of Flextronics Logistics USA, Inc. in Memphis Tennessee. The application was filed on August 19...

EC Competition law and environmental protection

Energy Technology Data Exchange (ETDEWEB)

Rantala, M.

1996-12-31

Due to the increasing attention paid on environmental protection, by the European Community, the Member States and the consumers, undertakings are forced to adjust their policies to meet the new demands posed by public authorities and the market. This has an inevitable impact on competition. No matter how acceptable the goals were, the means are to be assessed also from the competition law point of view. The objective of this study is to analyze the situations where conflicts may take place, the main sources of research being the principles of law relating to the Treaty ,the judgements of the European Court of Justice, the Commission Decisions and other official documents of the Community as well as legal literature. This study classifies the Community and Member State instruments which are used for environmental protection into four categories. These are legislative, market-based, horizontal and financial supporting instruments. Undertakings` environmental practices, which are capable of affecting competition, are examined under Articles 85 and 86 EC, some attention being paid also to Article 90 EC. The touching points of competition policy and environmental protection in such cases are scrutinized under three headings. These are the two, in this case, most relevant public instruments, ie. legislative and market-based measures, and the voluntary actions of undertakings. (42 refs.)

Enhanced CANDU 6 (EC6): a proven mid-sized reactor with fuel cycle capability

International Nuclear Information System (INIS)

Hopwood, J.; Soulard, M.; Hastings, I.J.

2011-01-01

Atomic Energy of Canada (AECL) is finalizing development of the Enhanced CANDU 6 (EC6), which incorporates the CANDU 6's well-proven features, and adds enhancements that make the reactor even more safe and easier to operate. The EC6 is the only mid-sized reactor (700 MWe class) with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. Changes are incremental and consistent with the CANDU 6 project approach. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. Containment and seismic capability are upgraded to meet modern standards. The first deployment of the EC6 is anticipated in Canada; international markets are also being pursued. AECL is performing a comprehensive review of the EC6 design in the wake of the Fukushima accident, will review lessons learned, and incorporate any necessary improvements into new build design. (author)

Enhanced CANDU 6 (EC6): a proven mid-sized reactor with fuel cycle capability

International Nuclear Information System (INIS)

Hopwood, J.; Soulard, M.; Hastings, I.J.

2011-01-01

Atomic Energy of Canada (AECL) is finalizing development of the Enhanced CANDU 6 (EC6), which incorporates the CANDU 6's well-proven features, and enhancements that make the reactor even more safe and easier to operate. The EC6 is the only mid-sized reactor (700 MWe class) with a proven pedigree that meets modern reactor expectations and regulatory standards. It is sized for smaller grids and also has outstanding fuel-cycle capability. Changes are incremental and consistent with the CANDU 6 project approach. The EC6 utilizes modern computers and a distributed control system housed in an advanced control room which, along with automated testing and on-line diagnostics, make the plant easier and safer to operate, with minimal operator intervention. Containment and seismic capability are upgraded to meet modern standards. The first deployment of the EC6 is anticipated in Canada; international markets are also being pursued. AECL is performing a comprehensive review of the EC6 design in the wake of the Fukushima accident, will review lessons learned, and incorporate any necessary improvements into new build design. (author)

Heidegeer a Kierkegaard: pojetí boha a posvátného

Directory of Open Access Journals (Sweden)

Jiří Olšovský

2010-05-01

Full Text Available Text je zaměřen zejména na posvátný charakter světa a přírody, jak se zračí v pojetí bytí a božského u Heideggera a Kierkegaarda. Bytí zde zůstává tématem, spolu se základní péčí a starostí o svět a věci v něm. Ukazuje se, že spodní proud Heideggerova myšlení je znovu-probuzení „zbožného myšlení“ a rezervovanost. Zejména článek chce upozornit na Heideggerovy odkazy k mysticismu a Kierkegaardův „pramen víry“. V úvahách nad Heideggerovým dílem je třeba se zamyslet, zda otázka Boha může být rozhodnuta jen v blízkosti bytí a svatosti. O noumenální charakter naší „zahrady“ je nezbytné znovu náležitě pečovat, a zaposlouchat se proto do řeči těch, kteří byli s to se přiblížit k bytí a božskému, k posvátnému pobývání na zemi.

Anal Carcinoma: Impact of TN Category of Disease on Survival, Disease Relapse, and Colostomy Failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial

Science.gov (United States)

Gunderson, Leonard L.; Moughan, Jennifer; Ajani, Jaffer A.; Pedersen, John E.; Winter, Kathryn A.; Benson, Al B.; Thomas, Charles R.; Mayer, Robert J.; Haddock, Michael G.; Rich, Tyvin A.; Willett, Christopher G.

2013-01-01

Purpose The long-term update of US GI Intergroup RTOG 98-11 anal cancer trial found that concurrent chemoradiation (CCRT) with fluorouracil (5-FU) plus mitomycin had a significant impact on disease-free survival (DFS) and overall survival (OS) compared with induction plus concurrent 5-FU plus cisplatin. The intent of the current analysis was to determine the impact of tumor node (TN) category of disease on survival (DFS and OS), colostomy failure (CF), and relapse (local-regional failure [LRF] and distant metastases [DM]) in this patient group. Methods and Materials DFS and OS were estimated univariately by using the Kaplan-Meier method, and 6 TN categories were compared by the log–rank test (T2N0, T3N0, T4N0, T2N1-3, T3N1-3, and T4N1-3). Time to relapse and colostomy were estimated by the cumulative incidence method, and TN categories were compared using Gray’s test. Results Of 682 patients, 620 were analyzable for outcomes by TN category. All endpoints showed statistically significant differences among the TN categories of disease (OS, P<.0001; DFS, P<.0001; LRF, P<.0001; DM, P=.0011; CF, P=.01). Patients with the poorest OS, DFS, and LRF outcomes were those with T3-4N-positive (+) disease. CF was lowest for T2N0 and T2N+ (11%, 11%, respectively) and worst for the T4N0, T3N+, and T4N+ categories (26%, 27%, 24%, respectively). Conclusions TN category of disease has a statistically significant impact on OS, DFS, LRF, DM, and CF in patients treated with CCRT and provides excellent prognostic information for outcomes in patients with anal carcinoma. Significant challenges remain for patients with T4N0 and T3-4N+ categories of disease with regard to survival, relapse, and CF and lesser challenges for T2-3N0/T2N+ categories. PMID:24035327

Anal Carcinoma: Impact of TN Category of Disease on Survival, Disease Relapse, and Colostomy Failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial

Energy Technology Data Exchange (ETDEWEB)

Gunderson, Leonard L., E-mail: gunderson.leonard@mayo.edu [Mayo Clinic Cancer Center, Scottsdale, Arizona (United States); Moughan, Jennifer [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States); Ajani, Jaffer A. [The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Pedersen, John E. [Cross Cancer Institute, Edmonton, Alberta (Canada); Winter, Kathryn A. [Radiation Therapy Oncology Group, Philadelphia, Pennsylvania (United States); Benson, Al B. [Northwestern University, Chicago, Illinois (United States); Thomas, Charles R. [Knight Cancer Institute/Oregon Health and Science University, Portland, Oregon (United States); Mayer, Robert J. [Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Haddock, Michael G. [Mayo Clinic Cancer Center, Rochester, Minnesota (United States); Rich, Tyvin A. [University of Virginia, Charlottesville, Virginia (United States); Willett, Christopher G. [Duke University, Durham, North Carolina (United States)

2013-11-15

Purpose: The long-term update of US GI Intergroup RTOG 98-11 anal cancer trial found that concurrent chemoradiation (CCRT) with fluorouracil (5-FU) plus mitomycin had a significant impact on disease-free survival (DFS) and overall survival (OS) compared with induction plus concurrent 5-FU plus cisplatin. The intent of the current analysis was to determine the impact of tumor node (TN) category of disease on survival (DFS and OS), colostomy failure (CF), and relapse (local-regional failure [LRF] and distant metastases [DM]) in this patient group. Methods and Materials: DFS and OS were estimated univariately by using the Kaplan-Meier method, and 6 TN categories were compared by the log–rank test (T2N0, T3N0, T4N0, T2N1-3, T3N1-3, and T4N1-3). Time to relapse and colostomy were estimated by the cumulative incidence method, and TN categories were compared using Gray's test. Results: Of 682 patients, 620 were analyzable for outcomes by TN category. All endpoints showed statistically significant differences among the TN categories of disease (OS, P<.0001; DFS, P<.0001; LRF, P<.0001; DM, P=.0011; CF, P=.01). Patients with the poorest OS, DFS, and LRF outcomes were those with T3-4N-positive (+) disease. CF was lowest for T2N0 and T2N+ (11%, 11%, respectively) and worst for the T4N0, T3N+, and T4N+ categories (26%, 27%, 24%, respectively). Conclusions: TN category of disease has a statistically significant impact on OS, DFS, LRF, DM, and CF in patients treated with CCRT and provides excellent prognostic information for outcomes in patients with anal carcinoma. Significant challenges remain for patients with T4N0 and T3-4N+ categories of disease with regard to survival, relapse, and CF and lesser challenges for T2-3N0/T2N+ categories.

Anal Carcinoma: Impact of TN Category of Disease on Survival, Disease Relapse, and Colostomy Failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial

International Nuclear Information System (INIS)

Gunderson, Leonard L.; Moughan, Jennifer; Ajani, Jaffer A.; Pedersen, John E.; Winter, Kathryn A.; Benson, Al B.; Thomas, Charles R.; Mayer, Robert J.; Haddock, Michael G.; Rich, Tyvin A.; Willett, Christopher G.

2013-01-01

Purpose: The long-term update of US GI Intergroup RTOG 98-11 anal cancer trial found that concurrent chemoradiation (CCRT) with fluorouracil (5-FU) plus mitomycin had a significant impact on disease-free survival (DFS) and overall survival (OS) compared with induction plus concurrent 5-FU plus cisplatin. The intent of the current analysis was to determine the impact of tumor node (TN) category of disease on survival (DFS and OS), colostomy failure (CF), and relapse (local-regional failure [LRF] and distant metastases [DM]) in this patient group. Methods and Materials: DFS and OS were estimated univariately by using the Kaplan-Meier method, and 6 TN categories were compared by the log–rank test (T2N0, T3N0, T4N0, T2N1-3, T3N1-3, and T4N1-3). Time to relapse and colostomy were estimated by the cumulative incidence method, and TN categories were compared using Gray's test. Results: Of 682 patients, 620 were analyzable for outcomes by TN category. All endpoints showed statistically significant differences among the TN categories of disease (OS, P<.0001; DFS, P<.0001; LRF, P<.0001; DM, P=.0011; CF, P=.01). Patients with the poorest OS, DFS, and LRF outcomes were those with T3-4N-positive (+) disease. CF was lowest for T2N0 and T2N+ (11%, 11%, respectively) and worst for the T4N0, T3N+, and T4N+ categories (26%, 27%, 24%, respectively). Conclusions: TN category of disease has a statistically significant impact on OS, DFS, LRF, DM, and CF in patients treated with CCRT and provides excellent prognostic information for outcomes in patients with anal carcinoma. Significant challenges remain for patients with T4N0 and T3-4N+ categories of disease with regard to survival, relapse, and CF and lesser challenges for T2-3N0/T2N+ categories

A Study on Partnering Mechanism in B to B EC Server for Global Supply Chain Management

Science.gov (United States)

Kaihara, Toshiya

B to B Electronic Commerce (EC) technology is now in progress and regarded as an information infrastructure for global business. As the number and diversity of EC participants grows at the agile environment, the complexity of purchasing from a vast and dynamic array of goods and services needs to be hidden from the end user. Putting the complexity into the EC system instead means providing flexible auction server for enabling commerce within different business units. Market mechanism could solve the product distribution problem in the auction server by allocating the scheduled resources according to market prices. In this paper, we propose a partnering mechanism for B to B EC with market-oriented programming that mediates amongst unspecified various companies in the trade, and demonstrate the applicability of the economic analysis to this framework after constructing a primitive EC server. The proposed mechanism facilitates sophisticated B to B EC, which conducts a Pareto optimal solution for all the participating business units in the coming agile era.

Expression of Finger Millet EcDehydrin7 in Transgenic Tobacco Confers Tolerance to Drought Stress.

Science.gov (United States)

Singh, Rajiv Kumar; Singh, Vivek Kumar; Raghavendrarao, Sanagala; Phanindra, Mullapudi Lakshmi Venkata; Venkat Raman, K; Solanke, Amolkumar U; Kumar, Polumetla Ananda; Sharma, Tilak Raj

2015-09-01

One of the critical alarming constraints for agriculture is water scarcity. In the current scenario, global warming due to climate change and unpredictable rainfall, drought is going to be a master player and possess a big threat to stagnating gene pool of staple food crops. So it is necessary to understand the mechanisms that enable the plants to cope with drought stress. In this study, effort was made to prospect the role of EcDehydrin7 protein from normalized cDNA library of drought tolerance finger millet in transgenic tobacco. Biochemical and molecular analyses of T0 transgenic plants were done for stress tolerance. Leaf disc assay, seed germination test, dehydration assay, and chlorophyll estimation showed EcDehydrin7 protein directly link to drought tolerance. Northern and qRT PCR analyses shows relatively high expression of EcDehydrin7 protein compare to wild type. T0 transgenic lines EcDehydrin7(11) and EcDehydrin7(15) shows superior expression among all lines under study. In summary, all results suggest that EcDehydrin7 protein has a remarkable role in drought tolerance and may be used for sustainable crop breeding program in other food crops.

Ecological audits under EC regulations: background and impact in practice

International Nuclear Information System (INIS)

Walther, T.

1995-01-01

There are publications discussing the practical aspects of the implementation of the EC Directive on ecological audits, but little has been published yet on the theoretical background of the directive. The contribution in hand is intended to elucidate the theoretical basis of this instrument in the context of the system of law, explains the term of ''sustainable development'' as a key term, and reveals problems encountered in the evaluation of environmental performance. This information will contribute to a better understanding of the meaning and purposes of the EC Directive, and will thus point out ways and means for direct implementation. (orig.) [de

Studies on absorption of EC waves in assisted startup experiment on FTU

Science.gov (United States)

Granucci, G.; Ricci, D.; Farina, D.; Figini, L.; Iraji, D.; Tudisco, O.; Ramponi, G.; Bin, W.

2012-09-01

Assistance of EC wave for plasma breakdown and current ramp up is the proposed scenario for the ITER case, characterized by low toroidal electric field. The experimental results on many tokamaks clearly indicate the capabilities of the proposed scheme to have a robust breakdown in ITER. The key aspect of this technique is the EC power required, strongly related to the absorption of the wave in the initial stage of plasma formation. This aspect is generally neglected due to the diagnostics difficulties in the plasma formation phase. As a consequence a multi-pass absorption scheme is usually considered reasonable, leading to a strong absorption after many reflections on the walls. The present study exploits the high temporal and spatial resolution of the fast scanning interferometer of FTU together with the measure of residual power obtained by a sniffer probe. The absorbed EC power is calculated considering also the polarization rotation and the subsequent mode conversion after incidence on the internal wall and compared with that derived from experimental data. The resulting EC power distribution can explain differences observed between perpendicular and oblique injection results, indicating future investigations to define ITER power requirements.

Studies on absorption of EC waves in assisted startup experiment on FTU

Directory of Open Access Journals (Sweden)

Ramponi G.

2012-09-01

Full Text Available Assistance of EC wave for plasma breakdown and current ramp up is the proposed scenario for the ITER case, characterized by low toroidal electric field. The experimental results on many tokamaks clearly indicate the capabilities of the proposed scheme to have a robust breakdown in ITER. The key aspect of this technique is the EC power required, strongly related to the absorption of the wave in the initial stage of plasma formation. This aspect is generally neglected due to the diagnostics difficulties in the plasma formation phase. As a consequence a multi-pass absorption scheme is usually considered reasonable, leading to a strong absorption after many reflections on the walls. The present study exploits the high temporal and spatial resolution of the fast scanning interferometer of FTU together with the measure of residual power obtained by a sniffer probe. The absorbed EC power is calculated considering also the polarization rotation and the subsequent mode conversion after incidence on the internal wall and compared with that derived from experimental data. The resulting EC power distribution can explain differences observed between perpendicular and oblique injection results, indicating future investigations to define ITER power requirements.

Upgrading from the Dicon Wiring Management system to IntEC at the Gentilly 2 station

International Nuclear Information System (INIS)

Theoret, P.A.

1995-01-01

The General Electric DICON Wiring Management system supplied to HQ during the construction of G2 is currently being replaced by the stand-alone version of the IntEC software developed by AECL. The reasons for replacing DICON and choosing lntEC are discussed. The different aspects of the two year DICON data conversion project are presented with the problems encountered and the means that were taken to resolve the problems. lntEC has shown our DICON data to be considerably more deficient than we had thought. This has increased the cost and the duration of the conversion process. However, correcting the errors during the conversion process provides us with much more accurate data. This should be viewed as an investment in configuration management. Many potential causes of future errors and potentially critical path delays have been removed. We have chosen to document the detailed procedures for the use of lntEC in our plant using a Windows Help File compiler. This also has been found to be extremely useful as a training tool as well as providing on-line help. The DICON data conversion into lntEC will not be completed until 1996. lntEC is not perfect. However, from what we have up to now, we are satisfied with the conviviality and efficiency of lntEC and with AECL's diligence in constantly aspiring in making it a better product. (author)

Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.

Science.gov (United States)

Baxley, Tamatha; Johnson, Dylan; Pinto, Jose R; Chalovich, Joseph M

2017-06-13

Striated muscle contraction is regulated by the actin-associated proteins tropomyosin and troponin. The extent of activation of myosin ATPase activity is lowest in the absence of both Ca 2+ and activating cross-bridges (i.e., S1-ADP or rigor S1). Binding of activating species of myosin to actin at a saturating Ca 2+ concentration stabilizes the most active state (M state) of the actin-tropomyosin-troponin complex (regulated actin). Ca 2+ binding alone produces partial stabilization of the active state. The extent of stabilization at a saturating Ca 2+ concentration depends on the isoform of the troponin subunits, the phosphorylation state of troponin, and, in the case of cardiac muscle, the presence of hypertrophic cardiomyopathy-producing mutants of troponin T and troponin I. Cardiac dysfunction is also associated with mutations of troponin C (TnC). Troponin C mutants A8V, C84Y, and D145E increase the Ca 2+ sensitivity of ATPase activity. We show that these mutants change the distribution of regulated actin states. The A8V and C84Y TnC mutants decreased the inactive B state distribution slightly at low Ca 2+ concentrations, but the D145E mutants had no effect on that state. All TnC mutants increased the level of the active M state compared to that of the wild type, at a saturating Ca 2+ concentration. Troponin complexes that contained two mutations that stabilize the active M state, A8V TnC and Δ14 TnT, appeared to be completely in the active state in the presence of only Ca 2+ . Because Ca 2+ gives full activation, in this situation, troponin must be capable of positioning tropomyosin in the active M state without the need for rigor myosin binding.

CREATINE PHOSPHOKINASE ISOENZYME-MB MASS (CK-MB MASS AND TROPONIN I (cTnI IN DOGS (Canis familiaris

Directory of Open Access Journals (Sweden)

Millena Vidal Freitas

2015-07-01

Full Text Available Cardiac markers, especially CK-MB mass and cTnI, have an essential role in both human and veterinary clinical and surgical cardiology, allowing a more precise and accurate diagnosis in myocardial lesions. The goal of this work was to measure these cardiac markers in veterinary medicine, improve their use and provide information about these laboratory methods that allow non-invasive health monitoring of the myocardial cell. Parameters quantification was obtained from sera of healthy dogs examined during routine procedures at the Small Animal Veterinary Hospital of Universidade Estadual do Norte Fluminense Darcy Ribeiro. The human chemiluminescence essay turbo kit (IMMULITE Turbo, Siemens ® test proved to be effective in canine species for both CK-MB mass and cTnI. In addition, the values found for CK-MB will significantly contribute to clinical routine or experimental work with dogs.

The VanE operon in Enterococcus faecalis N00-410 is found on a putative integrative and conjugative element, Tn6202.

Science.gov (United States)

Boyd, D A; Mulvey, M R

2013-02-01

To date no complete genetic structure of acquired DNA harbouring a d-Ala-d-Ser operon in an Enterococcus is known. We wished to characterize the acquired DNA harbouring the vanE operon located in the Enterococcus faecalis N00-410 chromosome. Whole genome sequencing of E. faecalis N00-410 was conducted by massively parallel sequencing. Two sequence contigs harbouring the vanE region were linked by PCR and the acquired DNA harbouring the vanE operon was completely characterized. Excision/integration of the region was determined by PCR and transfer attempted by conjugation. The regions flanking the vanE operon were analysed and a total of 42 open reading frames were identified in a region flanked by inverted terminal and direct repeats (Tn6202). Tn6202 could be excised from the chromosome, circularized and the target site rejoined, but transfer could not be demonstrated. The vanE operon was found on the putative integrative and conjugative element Tn6202 in the E. faecalis N00-410 chromosome. This represents the first characterization of acquired DNA harbouring a D-Ala-D-Ser operon.

MoisturEC: a new R program for moisture content estimation from electrical conductivity data

Science.gov (United States)

Terry, Neil; Day-Lewis, Frederick D.; Werkema, Dale D.; Lane, John W.

2018-01-01

Noninvasive geophysical estimation of soil moisture has potential to improve understanding of flow in the unsaturated zone for problems involving agricultural management, aquifer recharge, and optimization of landfill design and operations. In principle, several geophysical techniques (e.g., electrical resistivity, electromagnetic induction, and nuclear magnetic resonance) offer insight into soil moisture, but data‐analysis tools are needed to “translate” geophysical results into estimates of soil moisture, consistent with (1) the uncertainty of this translation and (2) direct measurements of moisture. Although geostatistical frameworks exist for this purpose, straightforward and user‐friendly tools are required to fully capitalize on the potential of geophysical information for soil‐moisture estimation. Here, we present MoisturEC, a simple R program with a graphical user interface to convert measurements or images of electrical conductivity (EC) to soil moisture. Input includes EC values, point moisture estimates, and definition of either Archie parameters (based on experimental or literature values) or empirical data of moisture vs. EC. The program produces two‐ and three‐dimensional images of moisture based on available EC and direct measurements of moisture, interpolating between measurement locations using a Tikhonov regularization approach.

Application of the EC eco-audit regulation in the energy industry

International Nuclear Information System (INIS)

Schulz, J.

1994-01-01

The eco-audit regulation isolates the precision of goals to improve operational environmental protection for observation, particularly with a view to the industrial energy economy. It is not wise without an investigation into the possible repercussions with other EU and national regulatory laws. Keywords here are: design of a heat application regulation according to the BImSchG, discussion over the introduction of an EC CO 2 Energy tax as well as the EC guidelines on reducing CO 2 emissions (SAVE). (orig./HP) [de

Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.

Directory of Open Access Journals (Sweden)

Ing-Marie Jonsson

2010-12-01

Full Text Available Ecs is an ATP-binding cassette (ABC transporter present in aerobic and facultative anaerobic gram-positive Firmicutes. Inactivation of Bacillus subtilis Ecs causes pleiotropic changes in the bacterial phenotype including inhibition of intramembrane proteolysis. The molecule(s transported by Ecs is (are still unknown.In this study we mutated the ecsAB operon in two Staphylococcus aureus strains, Newman and LS-1. Phenotypic and functional characterization of these Ecs deficient mutants revealed a defect in growth, increased autolysis and lysostaphin sensitivity, altered composition of cell wall proteins including the precursor form of staphylokinase and an altered bacterial surface texture. DNA microarray analysis indicated that the Ecs deficiency changed expression of the virulence factor regulator protein Rot accompanied by differential expression of membrane transport proteins, particularly ABC transporters and phosphate-specific transport systems, protein A, adhesins and capsular polysaccharide biosynthesis proteins. Virulence of the ecs mutants was studied in a mouse model of hematogenous S. aureus infection. Mice inoculated with the ecs mutant strains developed markedly milder infections than those inoculated with the wild-type strains and had consequently lower mortality, less weight loss, milder arthritis and decreased persistence of staphylococci in the kidneys. The ecs mutants had higher susceptibility to ribosomal antibiotics and plant alkaloids chelerythrine and sanguinarine.Our results show that Ecs is essential for staphylococcal virulence and antimicrobial resistance probably since the transport function of Ecs is essential for the normal structure and function of the cell wall. Thus targeting Ecs may be a new approach in combating staphylococcal infection.

Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.

Science.gov (United States)

Jonsson, Ing-Marie; Juuti, Jarmo T; François, Patrice; AlMajidi, Rana; Pietiäinen, Milla; Girard, Myriam; Lindholm, Catharina; Saller, Manfred J; Driessen, Arnold J M; Kuusela, Pentti; Bokarewa, Maria; Schrenzel, Jacques; Kontinen, Vesa P

2010-12-02

Ecs is an ATP-binding cassette (ABC) transporter present in aerobic and facultative anaerobic gram-positive Firmicutes. Inactivation of Bacillus subtilis Ecs causes pleiotropic changes in the bacterial phenotype including inhibition of intramembrane proteolysis. The molecule(s) transported by Ecs is (are) still unknown. In this study we mutated the ecsAB operon in two Staphylococcus aureus strains, Newman and LS-1. Phenotypic and functional characterization of these Ecs deficient mutants revealed a defect in growth, increased autolysis and lysostaphin sensitivity, altered composition of cell wall proteins including the precursor form of staphylokinase and an altered bacterial surface texture. DNA microarray analysis indicated that the Ecs deficiency changed expression of the virulence factor regulator protein Rot accompanied by differential expression of membrane transport proteins, particularly ABC transporters and phosphate-specific transport systems, protein A, adhesins and capsular polysaccharide biosynthesis proteins. Virulence of the ecs mutants was studied in a mouse model of hematogenous S. aureus infection. Mice inoculated with the ecs mutant strains developed markedly milder infections than those inoculated with the wild-type strains and had consequently lower mortality, less weight loss, milder arthritis and decreased persistence of staphylococci in the kidneys. The ecs mutants had higher susceptibility to ribosomal antibiotics and plant alkaloids chelerythrine and sanguinarine. Our results show that Ecs is essential for staphylococcal virulence and antimicrobial resistance probably since the transport function of Ecs is essential for the normal structure and function of the cell wall. Thus targeting Ecs may be a new approach in combating staphylococcal infection.

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Directory of Open Access Journals (Sweden)

Caroline B Madsen

Full Text Available Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited data have so far demonstrated the critical steps in glycan elongation that make aberrantly glycosylated mucins affect the interaction between cancer cells and cytotoxic effector cells of the immune system. Tn (GalNAc-Ser/Thr, STn (NeuAcα2-6GalNAc-Ser/Thr, T (Galβ1-3GalNAc-Ser/Thr, and ST (NeuAcα2-6Galβ1-3GalNAc-Ser/Thr antigens are recognized as cancer associated truncated glycans, and are expressed in many adenocarcinomas, e.g. breast- and pancreatic cancer cells. To investigate the role of the cancer associated glycan truncations in immune-mediated killing we created glyco-engineered breast- and pancreatic cancer cells expressing only the shortest possible mucin-like glycans (Tn and STn. Glyco-engineering was performed by zinc finger nuclease (ZFN knockout (KO of the Core 1 enzyme chaperone COSMC, thereby preventing glycan elongation beyond the initial GalNAc residue in O-linked glycans. We find that COSMC KO in the breast and pancreatic cancer cell lines T47D and Capan-1 increases sensitivity to both NK cell mediated antibody-dependent cellular-cytotoxicity (ADCC and cytotoxic T lymphocyte (CTL-mediated killing. In addition, we investigated the association between total cell surface expression of MUC1/MUC16 and NK or CTL mediated killing, and observed an inverse correlation between MUC16/MUC1 expression and the sensitivity to ADCC and CTL-mediated killing. Together, these data suggest that up-regulation of membrane bound mucins protects cells from immune mediated killing, and that particular glycosylation steps, as demonstrated for glycan elongation beyond Tn and STn, can be important for fine tuning of the immune escape mechanisms in cancer cells.

Usefulness of L,L-ethylenedicysteine - 99mTc complex (EC-99mTc) for the kidney investigations

International Nuclear Information System (INIS)

Surma, M.J.; Wiewiora, J.; Kapuscinksi, J.; Liniecki, J.

1992-01-01

To assess the usefulness of own EC- 99m Tc complex for the kidney function examination, the renoscintigraphy with EC- 99m Tc and clearance determinations were performed. During renoscintigraphy the kidney images were of superb quality, with overlaying organs (liver, spleen) not visualized. Renograms showed typical shapes, their TMAX and T1/2 values being insignificantly different from the obtained with other radiopharmaceuticals, used in renoscintigraphy (MAG 3 , hippuran). Very strict correlations were found between values of EC- 99m Tc and OIH- 131 I clearances (r=0.91) and excretion rate constants (r=0.92) of both radiopharmaceuticals. The correlation enabled formulation of an equation by which ERPF could be established from EC- 99m Tc clearance: ERPF OIH =1.245 x Cl EC +51.52. On the basis of this equation a lower boundary of the normal EC- 99m Tc clearance was established; it amounts to 300 ml/min/1.73 m 2 . (author). 17 refs, 5 figs, 1 tab

Spatial and Temporal Variations of EC and OC Aerosol Combustion Sources in a Polluted Metropolitan Area

Science.gov (United States)

Mouteva, G.; Randerson, J. T.; Fahrni, S.; Santos, G.; Bush, S. E.; Ehleringer, J. R.; Czimczik, C. I.

2015-12-01

Anthropogenic emissions of carbonaceous aerosols are a major component of fine air particulate matter (PM2.5) in polluted metropolitan areas and in the global atmosphere. Elemental (EC) and organic carbon (OC) aerosols influence Earth's energy balance by means of direct and indirect pathways and EC has been suggested as a better indicator of public health impacts from combustion-related sources than PM mass. Quantifying the contribution of fossil fuel and biomass combustion to the EC and OC emissions and their temporal and spatial variations is critical for developing efficient legislative air pollution control measures and successful climate mitigation strategies. In this study, we used radiocarbon (14C) to separate and quantify fossil and biomass contributions to a time series of EC and OC collected at 3 locations in Salt Lake City (SLC). Aerosol samples were collected on quartz fiber filters and a modified OC/EC analyzer was used with the Swiss_4S protocol to isolate and trap the EC fraction. Together with the total carbon (TC) content of the samples, the EC was analyzed for its 14C content with accelerator mass spectrometry. The 14C of OC was derived as a mass balance difference between TC and EC. EC had an annual average fraction modern of 0.13±0.06 and did not vary significantly across seasons. OC had an annual average FM of 0.49±0.13, with the winter mean (0.43±0.11) lower than the summer mean (0.64±0.13) at the 5% significance level. While the 3 stations were chosen to represent a variety of environmental conditions within SLC, no major differences in this source partitioning were observed between stations. During winter, the major sources of air pollutants in SLC are motor vehicles and wood stove combustion and determining their relative contributions has been the subject of debate. Our results indicated that fossil fuels were the dominant source of carbonaceous aerosols during winter, contributing 87% or more of the total EC mass and 40-75% of the OC

MoisturEC: A New R Program for Moisture Content Estimation from Electrical Conductivity Data.

Science.gov (United States)

Terry, Neil; Day-Lewis, Frederick D; Werkema, Dale; Lane, John W

2018-03-06

Noninvasive geophysical estimation of soil moisture has potential to improve understanding of flow in the unsaturated zone for problems involving agricultural management, aquifer recharge, and optimization of landfill design and operations. In principle, several geophysical techniques (e.g., electrical resistivity, electromagnetic induction, and nuclear magnetic resonance) offer insight into soil moisture, but data-analysis tools are needed to "translate" geophysical results into estimates of soil moisture, consistent with (1) the uncertainty of this translation and (2) direct measurements of moisture. Although geostatistical frameworks exist for this purpose, straightforward and user-friendly tools are required to fully capitalize on the potential of geophysical information for soil-moisture estimation. Here, we present MoisturEC, a simple R program with a graphical user interface to convert measurements or images of electrical conductivity (EC) to soil moisture. Input includes EC values, point moisture estimates, and definition of either Archie parameters (based on experimental or literature values) or empirical data of moisture vs. EC. The program produces two- and three-dimensional images of moisture based on available EC and direct measurements of moisture, interpolating between measurement locations using a Tikhonov regularization approach. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

Effects of Sludge Compost on EC value of Saline Soil and Plant Height of Medicago

Science.gov (United States)

Sun, Chongyang; Zhao, Ke; Chen, Xing; Wang, Xiaohui

2017-12-01

In this study, the effects of sludge composting on the EC value of saline soil and the response to Medicago plant height were studied by planting Medicago with pots for 45 days in different proportions as sludge composting with saline soil. The results showed that the EC value of saline soil did not change obviously with the increase of fertilization ratio,which indicated that the EC value of saline soil was close to that of the original soil. The EC decreased by 31.45% at fertilization ratio of 40%. The height of Medicago reached the highest at 40% fertilization ratio, and that was close to 60% fertilization ratio, and the difference was significant with other treatments. By comprehensive analyse and compare,the optimum application rate of sludge compost was 40% under this test condition.

Production of diketopiperazine derivative cyclo (l-leu-l-arg) by streptomyces sp. tn262 after exposure to heat-killed fungus fusarium sp

International Nuclear Information System (INIS)

Elleuch, L.; Smaoui, S.; Najah, S.; Sellem, I

2013-01-01

In a screening program for new active secondary metabolites producers, a strain of Streptomyces called TN262 was isolated from Tunisian soil and selected for its ability to produce eleven active compounds in pure culture conditions. In this work, the effect of different concentrations of heat-killed fungus Fusarium sp. on the production of active compounds by TN262 strain was studied. The ethyl acetate extract from the culture of Streptomyces sp. TN262 combined with heat-killed Fusarium sp. at 50 micro g/ml inhibited the growth of the three used indicator microorganisms. In fact, an increase of 36%, 21% and 20% in inhibitory activity was obtained against Micrococcus luteus LB 14110, Escherichia coli ATCC 8739 and Fusarium sp. respectively. The HPLC chromatographic profiles of the ethyl acetate extracts from both culture conditions were different and an additional active compound was produced only under induced conditions. This active component was isolated and identified as Cyclo (L-Leu-L-Arg) (1), a diketopiperazine derivative, possessing antibacterial and antifungal activity. Consequently, this study showed that the addition of heat-killed fungus is a useful method for inducing the production of bioactive compounds. (author)

GPM GROUND VALIDATION ENVIRONMENT CANADA (EC) RADIOSONDE GCPEX V1

Data.gov (United States)

National Aeronautics and Space Administration — The GPM Ground Validation Environment Canada (EC) Radiosonde GCPEx dataset provides measurements of pressure, temperature, humidity, and winds collected by Vaisala...

On the robustness of EC-PC spike detection method for online neural recording.

Science.gov (United States)

Zhou, Yin; Wu, Tong; Rastegarnia, Amir; Guan, Cuntai; Keefer, Edward; Yang, Zhi

2014-09-30

Online spike detection is an important step to compress neural data and perform real-time neural information decoding. An unsupervised, automatic, yet robust signal processing is strongly desired, thus it can support a wide range of applications. We have developed a novel spike detection algorithm called "exponential component-polynomial component" (EC-PC) spike detection. We firstly evaluate the robustness of the EC-PC spike detector under different firing rates and SNRs. Secondly, we show that the detection Precision can be quantitatively derived without requiring additional user input parameters. We have realized the algorithm (including training) into a 0.13 μm CMOS chip, where an unsupervised, nonparametric operation has been demonstrated. Both simulated data and real data are used to evaluate the method under different firing rates (FRs), SNRs. The results show that the EC-PC spike detector is the most robust in comparison with some popular detectors. Moreover, the EC-PC detector can track changes in the background noise due to the ability to re-estimate the neural data distribution. Both real and synthesized data have been used for testing the proposed algorithm in comparison with other methods, including the absolute thresholding detector (AT), median absolute deviation detector (MAD), nonlinear energy operator detector (NEO), and continuous wavelet detector (CWD). Comparative testing results reveals that the EP-PC detection algorithm performs better than the other algorithms regardless of recording conditions. The EC-PC spike detector can be considered as an unsupervised and robust online spike detection. It is also suitable for hardware implementation. Copyright © 2014 Elsevier B.V. All rights reserved.

Damage Detection Response Characteristics of Open Circuit Resonant (SansEC) Sensors

Science.gov (United States)

Dudley, Kenneth L.; Szatkowski, George N.; Smith, Laura J.; Koppen, Sandra V.; Ely, Jay J.; Nguyen, Truong X.; Wang, Chuantong; Ticatch, Larry A.; Mielnik, John J.

2013-01-01

The capability to assess the current or future state of the health of an aircraft to improve safety, availability, and reliability while reducing maintenance costs has been a continuous goal for decades. Many companies, commercial entities, and academic institutions have become interested in Integrated Vehicle Health Management (IVHM) and a growing effort of research into "smart" vehicle sensing systems has emerged. Methods to detect damage to aircraft materials and structures have historically relied on visual inspection during pre-flight or post-flight operations by flight and ground crews. More quantitative non-destructive investigations with various instruments and sensors have traditionally been performed when the aircraft is out of operational service during major scheduled maintenance. Through the use of reliable sensors coupled with data monitoring, data mining, and data analysis techniques, the health state of a vehicle can be detected in-situ. NASA Langley Research Center (LaRC) is developing a composite aircraft skin damage detection method and system based on open circuit SansEC (Sans Electric Connection) sensor technology. Composite materials are increasingly used in modern aircraft for reducing weight, improving fuel efficiency, and enhancing the overall design, performance, and manufacturability of airborne vehicles. Materials such as fiberglass reinforced composites (FRC) and carbon-fiber-reinforced polymers (CFRP) are being used to great advantage in airframes, wings, engine nacelles, turbine blades, fairings, fuselage structures, empennage structures, control surfaces and aircraft skins. SansEC sensor technology is a new technical framework for designing, powering, and interrogating sensors to detect various types of damage in composite materials. The source cause of the in-service damage (lightning strike, impact damage, material fatigue, etc.) to the aircraft composite is not relevant. The sensor will detect damage independent of the cause

Archive of Geosample Data and Information from the U.S. Extended Continental Shelf (ECS) Project.

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Geological samples collected as part of the U.S. Extended Continental Shelf (ECS) Project are curated by the U.S. Geological Survey, a partner in the ECS Project. To...

ESCAPE: an integrated climate model for the EC

International Nuclear Information System (INIS)

Rotmans, J.

1992-01-01

A framework has been developed for the evaluation of policy options for climate change, called ESCAPE (Evaluation of Strategies to address Climate change by Adapting to and Preventing Emissions). ESCAPE consists of a suite of linked models which enables scenarios of greenhouse gas emissions to be constructed and their impact on global and regional climate and sea level and sectors of the European economy to be assessed. Conclusions resulting from simulations with the ESCAPE 1.1 model include: the major problem of a climate change for the EC is a sea level rise; Greece, Italy, Portugal and Spain will be faced with higher costs in the agricultural sector; worldwide implementation of an EC carbon tax leads to about 12% lower worldwide CO 2 emissions; to stabilize CO 2 emissions an Ecotax of 18 dollars per barrel would be required; and in all cases the rate of global temperature increase will be above the rate of 0.1 degree C per decade for the coming 40 years. 2 figs

Business-to-business electronic commerce systems and services. Smart EC solution; Kigyoka nrenkei system solution system. Smart EC solution

Energy Technology Data Exchange (ETDEWEB)

Setoguchi, T.; Manchu, Y.; Katsumata, M. [Toshiba Corp., Tokyo (Japan)

2000-04-01

Toshiba provides a range of information technology (IT) solutions called SmartEC Solution, which includes business-to-business electronic commerce systems and services based on international standards and industrial know-how, especially our electronic data interchange (EDI) know-how as a manufacturer. These IT solutions are supplied as services covering strategy planning, system integration, and application service provider based on five types of business-to-business electronic commerce. (author)

High-Level Heat Resistance of Spores of Bacillus amyloliquefaciens and Bacillus licheniformis Results from the Presence of a spoVA Operon in a Tn1546 Transposon

Science.gov (United States)

Berendsen, Erwin M.; Koning, Rosella A.; Boekhorst, Jos; de Jong, Anne; Kuipers, Oscar P.; Wells-Bennik, Marjon H. J.

2016-01-01

Bacterial endospore formers can produce spores that are resistant to many food processing conditions, including heat. Some spores may survive heating processes aimed at production of commercially sterile foods. Recently, it was shown that a spoVA operon, designated spoVA2mob, present on a Tn1546 transposon in Bacillus subtilis, leads to profoundly increased wet heat resistance of B. subtilis spores. Such Tn1546 transposon elements including the spoVA2mob operon were also found in several strains of Bacillus amyloliquefaciens and Bacillus licheniformis, and these strains were shown to produce spores with significantly higher resistances to wet heat than their counterparts lacking this transposon. In this study, the locations and compositions of Tn1546 transposons encompassing the spoVA2mob operons in B. amyloliquefaciens and B. licheniformis were analyzed. Introduction of these spoVA2mob operons into B. subtilis 168 (producing spores that are not highly heat resistant) rendered mutant 168 strains that produced high-level heat resistant spores, demonstrating that these elements in B. amyloliquefaciens and B. licheniformis are responsible for high level heat resistance of spores. Assessment of growth of the nine strains of each species between 5.2°C and 57.7°C showed some differences between strains, especially at lower temperatures, but all strains were able to grow at 57.7°C. Strains of B. amyloliquefaciens and B. licheniformis that contain the Tn1546 elements (and produce high-level heat resistant spores) grew at temperatures similar to those of their Tn1546-negative counterparts that produce low-level heat resistant spores. The findings presented in this study allow for detection of B. amyloliquefaciens and B. licheniformis strains that produce highly heat resistant spores in the food chain. PMID:27994575

Drug: D08017 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available D08017 Drug Flucloxacillin magnesium; Floxapen (TN) ... (C19H16ClFN3O5S)2. Mg D08017....cillin Penicillinase [EC:3.5.2.6]-resistant penicillin penicillin binding protein ... PubChem: 96024710 LigandBox: D08017 ...

Lunar Module ECS (Environmental Control System) - Design Considerations and Failure Modes. Part 1

Science.gov (United States)

Interbartolo, Michael

2009-01-01

Design considerations and failure modes for the Lunar Module (LM) Environmental Control System (ECS) are described. An overview of the the oxygen supply and cabin pressurization, atmosphere revitalization, water management and heat transport systems are provided. Design considerations including reliability, flight instrumentation, modularization and the change to the use of batteries instead of fuel cells are discussed. A summary is provided for the LM ECS general testing regime.

IHF-independent assembly of the Tn10 strand transfer transpososome: implications for inhibition of disintegration

OpenAIRE

Stewart, Barry J.; Wardle, Simon J.; Haniford, David B.

2002-01-01

The frequency of DNA transposition in transposition systems that employ a strand transfer step may be significantly affected by the occurrence of a disintegration reaction, a reaction that reverses the strand transfer event. We have asked whether disintegration occurs in the Tn10 transposition system. We show that disintegration substrates (substrates constituting one half of the strand transfer product) are assembled into a transpososome that mimics the strand transfer intermediate. This str...

Experimental Study on Performance of EC-120 Wet-mixing Modified Asphalt Cementing Materials%EC-120温拌改性沥青胶结料性能试验研究

Institute of Scientific and Technical Information of China (English)

周刚; 唐江; 谭昆华; 谭巍

2012-01-01

This paper carries out experimental study on rotational viscosity, normal performance indices and rheological properties, etc. of EC-120 organic viscosity reducing and wet-mixing modified asphalt, the experiment shows that EC-120 as an organic additive with the melting point at approximate 100 t is well compatible with asphalt and easy to prepare without problem of isolation. The experiment also shows EC-120 in wet-mixing modified asphalt can reduce high-temperature viscosity and increase medium and low-temperature viscosity of asphalt so as to decrease mixing and compacting temperature of asphalt mixtures; can reduce needle penetration and increase softening point and anti-rutting factor so as to improve high-temperature stability of asphalt remarkably; and will enable reduction of ductility, increase of fatigue factor, increase of creepage stiffness and reduction of deformation rate of wet-mixing modified asphalt, which slightly have negative influence on anti-fatigue and low-temperature cracking properties of asphalt.%对EC-120有机降粘温拌改性沥青进行旋转粘度、常规性能指标、流变特性等试验研究,试验表明,EC- 120作为一种熔点在100℃左右的有机添加剂,与沥青相容性好,制备容易,不存在离析问题.试验还表明在温拌改性沥青中,EC-120可降低沥青的高温粘度,提高中低温粘度,从而降低沥青混合料的拌和和压实温度;可降低沥青针入度,提高软化点和抗车辙因子,从而大幅改善沥青的高温稳定性;会使温拌改性沥青的延度降低,疲劳因子增大,蠕变劲度增大,变形速率减小,对沥青的抗疲劳和低温抗开裂性能略有消极影响.

Normal human serum (HS) prevents oxidant-induced lysis of cultured endothelial cells (ECs)

International Nuclear Information System (INIS)

Callahan, K.S.; Harlan, J.M.

1986-01-01

Most studies demonstrating oxidant lysis of cultured ECs are performed in serum-free media or media containing low concentrations of bovine serum. The authors found that HS protects human and bovine ECs from lysis caused by reagent H 2 O 2 or glucose/glucose oxidase (GO)-generated H 2 O 2 . EC injury was assessed by 51 Cr release, cell detachment, or trypan blue dye exclusion. Protective HS activity was dose-dependent with concentrations greater than or equal to 25% preventing lethal injury. Cytotoxicity at 24 hrs, induced by 20 mU/ml GO, was 90.1 +/- 5.2% without HS vs 1.7 +/- 4.6% with 25% HS present (20 exp). Similar protection was observed with heparinized plasma. Of note, comparable concentrations of bovine serum were devoid of protective activity. Addition of fatty acid-free albumin to the media was also without protective effect. Preliminary characterization showed HS activity was stable to 60 0 C for 30 min, non-dialyzable at 25,000 MW cutoff, and retained in delipidated serum. The HS protection was not merely due to scavenging of exogenous H 2 O 2 as A23187-induced EC lysis was also prevented by HS. Protective activity was not reproduced by purified cerruloplasmin or transferrin. In conclusion, unidentified factor(s) present in HS protect cultured ECs from oxidant-induced lysis. Since endothelium is normally exposed to 100% plasma, the authors suggest that in vitro studies of oxidant-mediated injury be performed in the presence of HS. Factor(s) in HS may play an important role in modulating oxidant-induced vascular injury in vivo

Studies on the process of attachment of diazotroph alcaligenes faecalis and its Tn5 mutants to rice roots using 15N-labelling technique

International Nuclear Information System (INIS)

Fang Xuanjun; Lin Min; You Chongbiao

1993-09-01

By using 15 N-labelling technique and Tn5-induced mutants the attachment of associative diazotroph Alcaligenes faecalis to intact rice plants was examined in vitro. Three distinguished modes of attachment of Alcaligenes faecalis: adsorption, anchoring and colonization were proposed by using 15 N-labelling bacterial cells and Tn5-induced mutants. Che - mutants affected on adsorption, but not on anchoring. Exo - Che - mutant is defective in both adsorption and anchoring. Exo - or exo ++ mutants are only defective in anchoring. Effective colonization is benefit for establishment on the associative system. The data also indicated that EPS (exopolysaccharide) play rather important roles in the association between the host plant and bacteria

Exact comparison of dose rate measurements and calculation of TN12/2 packages

International Nuclear Information System (INIS)

Taniuchi, H.; Matsuda, F.

1998-01-01

Both of dose rate measurements of TN 12/2 package and calculations by Monte Carlo code MORSE in SCALE code system and MCNP were performed to evaluate the difference between the measurement and the calculation and finding out the cause of the difference. The calculated gamma-ray dose rates agreed well with measured ones, but calculated neutron dose rates overestimated more than a factor of 1.7. When considering the cause of the difference and applying the modification into the neutron calculation, the calculated neutron dose rates become to agree well, and the factor decreased to around 1.3. (authors)

Development of EC technology in JAERI

International Nuclear Information System (INIS)

Sakamoto, Keishi; Takahashi, Koji; Kasugai, Atsushi; Hayashi, Kenichi; Ikeda, Yoshitaka; Kajiwara, Ken; Fujii, Tsuneyuki; Imai, Tsuyoshi; Kariya, Tsuyoshi; Mitsunaka, Yoshika

2003-01-01

Recent progress of electron cyclotron (EC) heating and current drive technologies in JAERI is reported. In 170 GHz gyrotron development, 0.9 MW/9.2 sec (efficiency: 43%), 0.5 MW/30 sec (46%), etc, have been demonstrated. As for 110 GHz gyrotron, 1 MW/5 sec and 1.2 MW/4.1 sec were obtained. Using four 110 GHz gyrotrons, a 3 MW power injection into JT- 60U plasma was carried out. In parallel, a launcher design and its development that includes neutron irradiation of the launcher components and a remote steering launcher are underway for ITER application. (authors)

SerpinE2, a poor biomarker of endometrial cancer, promotes the proliferation and mobility of EC cells.

Science.gov (United States)

Shen, Yuan; Wang, Xiaoyu; Xu, Jianping; Lu, Lin

2017-07-04

The SerpinE2 pathway is evolutionarily conserved and plays an important role in tumorigenesis. SerpinE2 (a small ubiquitin-related modifier), like ubiquitin, conjugates SerpinE2 proteins onto lysine residues of target proteins. SerpinE2 over-expression has been found in several tumors. Here, we detected the level of SerpinE2 in 72 samples of EC tissue using immunohistochemistry to assess the role of SerpinE2 in EC prognosis. Meanwhile, we knocked down SerpinE2 by siRNA in the HTB-111 and Ishikawa EC cell lines and analyzed the viability and mobility change using an MTT assay, an annexin V/PI apoptosis assay, a wound scratch test and a transwell assay. A Kaplan-Meier analysis indicated a negative correlation between the level of SerpinE2 and the EC prognosis. Silencing SerpinE2 induced cell apoptosis and reduced the migration ability. Our data suggest SerpinE2 works as an oncogene in EC.

Panovnické postavy v závěru schodištních maleb

Czech Academy of Sciences Publication Activity Database

Kubínová, Kateřina

2006-01-01

Roč. 13, příl. (2006), s. 23-36 ISSN 1212-1487. [Schodištní cykly Velké věže hradu Karlštejna. Stav po restaurování. Praha, 05.05.2004-07.05.2004] R&D Projects: GA AV ČR(CZ) IAA8033301 Institutional research plan: CEZ:AV0Z80330511 Keywords : Bohemian medieval wall painting * Karlštejn * Charles IV Subject RIV: AL - Art, Architecture, Cultural Heritage

PRODUCTION OF BACTERIOCIN EC2 AND ITS INTERFERENCE IN THE GROWTH OF SALMONELLA TYPHI IN A MILK MATRIX

Directory of Open Access Journals (Sweden)

Yuri de Jesus Lopes de Abreu

2013-08-01

Full Text Available Bacterial interference can occur through various mechanisms, including the production of peroxides, acids, ammonia, bacteriolytic enzymes or bacteriocins. The strain Escherichia coli EC2 produces the antimicrobial substance (AMS EC2, able to inhibit different strains of Gram-negative bacteria isolated from food, as E. coli and Salmonella sp. The activity of AMS EC2 was lost after treatment with proteolytic enzymes, indicating the presence of an active proteinaceous compound, suggesting that it is a bacteriocin. The substance, renamed bacteriocin EC2, has its better production when the producer strain is grown on Casoy medium, at 37ºC and pH 6.0, without NaCl addition, but it is also able to be produced in milk. When co-cultivated in UHT milk with the producer strain E. coli EC2, the growth of the indicator strain Salmonella Typhi is totally inhibited within the first 4 hours of incubation, suggesting a potential application of bacteriocin EC2 in the control of Salmonella sp. e.g. in foods.

Clinical comparison of technetium-99m-EC, technetium-99-m-MAG3 and Iodine-131-OIH in renal disorders

International Nuclear Information System (INIS)

Kabasakal, L.; Turoglu, T.; Oensel, C.

1995-01-01

Technetium-99m-ethylenedicysteine has recently been developed for renal function studies. The pharmacokinetics of 99m Tc-EC were studied by constant infusion technique and compared with 99m Tc-MAG3 and 131 I-OIH in 11 patients with various renal disorders. After giving a 7.4 MBq 131 I-OIH and 90-110 MBq 99m Tc-EC or 99m Tc-MAG3 bolus, a constant infusion (MBq/ml) 99m Tc--agent and 0.07 MBq/m 131 I-OIH was started. Sixteen blood and five urine samples were obtained over three hr. The renal clearance of 99m Tc-EC was higher than than of 99m Tc-MAG3. The 99m Tc-EC/OIH and 99m Tc-MAG3/OIH ratios were 0.75 ± 0.05 and 0.55 ± 0.10 (p=0.00087), respectively. The distribution volume of 99m Tc-EC was also higher than that of 99m Tc-MAG3 (15722 ± 4644 and 9509 ± 2788 ml/1.73m 2 , respectively; p=0.072). The 99m Tc-EC/OIH and 99m Tc-MAG/OIH distribution volume ratios were 1.03 ± 0.14 and 0.55 ± 0.10, respectively (p = 0.0003). The 60-min excretion values of 99m Tc-EC and 99m Tc-MAG3 were compared to that of OIH. The 99m Tc-EC/OIH and 99m Tc-MAG3/OIH excretion ratios were 0.96 ± 0.06 and 1.07 ± 0.10, respectively (p=0.162). The protein binding of 99m -EC and OIH were found to be 34% ±4 and 66% ±5, respectively (p 99m Tc-EC was negligible (3% ±1.2) in comparison to OIH (27% ±3; p 99m Tc-EC. This agent has good potential for renal function evaluation. 32 refs., 5 tabs

Achievements and bottlenecks in humanitarian demining EU-funded research: final results from the EC DELVE project

Science.gov (United States)

Sahli, Hichem; Bruschini, Claudio; Van Kempen, Luc; Schleijpen, Ric; den Breejen, Eric

2008-04-01

The EC DELVE Support Action project has analyzed the bottlenecks in the transfer of Humanitarian Demining (HD) technology from technology development to the use in the field, and drawn some lessons learned, basing itself on the assessment of the European Humanitarian Demining Research and Technology Development (RTD) situation from early 1990 until 2006. The situation at the European level was analyzed with emphasis on activities sponsored by the European Commission (EC). This was also done for four European countries and Japan, with emphasis on national activities. The developments in HD during the last 10 years underline the fact that in a number of cases demining related developments have been terminated or at least put on hold. The study also showed that the funding provided by the EC under the Framework Program for RTD has led directly to the creation of an extensive portfolio of Humanitarian Demining technology development projects. The latter provided a range of research and supporting measures addressing the critical issues identified as a result of the regulatory policies developed in the field of Humanitarian Demining over the last ten years. However, the range of instruments available to the EC to finance the necessary research and development were limited, to pre-competitive research. The EC had no tools or programs to directly fund actual product development. As a first consequence, the EC funding program for development of technology for Humanitarian Demining unfortunately proved to be largely unsuitable for the small-scale development needed in a field where there is only a very limited market. As a second consequence, most of the research has been demonstrator-oriented. Moreover, the timeframe for RTD in Humanitarian Demining has not been sufficiently synchronized with the timeframe of the EC policies and regulations. The separation of the Mine Action and RTD funding streams in the EC did also negatively affect the take-up of new technologies. As a

The biodistribution and radiation dosimetry of 99Tcmm-EC-DG in normal volunteers

International Nuclear Information System (INIS)

Tang Jun; Yang Yi; Liu Zengli; Shi Yizhen

2010-01-01

The objective of this study is to evaluate the biodistribution of technetium-99m labeled ethylenedicysteine-deoxyglucose ( 99 Tc m -EC-DG) and to calculate its internal radiation absorbed dose in normal volunteers. 740 MBq 99 Tc m -EC-DG was injected into the antecubital vein. 2 ml blood were sampled from the contralateral antecubital vein at different time after the injection, and its radioactivity was measured. The bi-exponential curve of time-radioactivity of blood and the dynamic parameters were obtained by using ORIGIN 5.0. Urine was collected in 24 hours after the injection and the percentage of Radioactivity excreted by urine to the total injected radioactivity was calculated. The anterior and posterior whole body imaging were acquired at different time after the injection of 740 MBq 99 Tc m -EC-DG. The region of interest of these referring organs and tissues was drawn, their radioactivity at different time was calculated. The bi-exponential curve of time-radioactivity of every organ was obtained by using ORIGIN 5.0, and then cumulated radioactivity and retaining time of 99 Tcm-EC-DG were calculated and input into the software MIRDOSE 3.0 to obtain the radiation absorbed dose of every organ and tissue. The heart rate, blood pressure and breathing frequency is normal after the injection. The male volunteer's T1/2α is 39 seconds, T1/2β is 59 minutes and that of female volunteer is 21 seconds and 61 minutes. 99 Tc m -EC-DG imaging is safe, and its characteristic of biodistribution in normal volunteer makes it easy to accumulate in tumor. Brain is not imaged, the uptake of muscle is low. The absorbed dose of every organ is far lower than that of the public annual average limitation. (authors)

Expression of a finger millet transcription factor, EcNAC1, in tobacco confers abiotic stress-tolerance.

Directory of Open Access Journals (Sweden)

Venkategowda Ramegowda

Full Text Available NAC (NAM, ATAF1-2, and CUC2 proteins constitute one of the largest families of plant-specific transcription factors and have been shown to be involved in diverse plant processes including plant growth, development, and stress-tolerance. In this study, a stress-responsive NAC gene, EcNAC1, was isolated from the subtracted stress cDNA library generated from a drought adapted crop, finger millet, and characterized for its role in stress-tolerance. The expression analysis showed that EcNAC1 was highly induced during water-deficit and salt stress. EcNAC1 shares high amino acid similarity with rice genes that have been phylogenetically classified into stress-related NAC genes. Our results demonstrated that tobacco transgenic plants expressing EcNAC1 exhibit tolerance to various abiotic stresses like simulated osmotic stress, by polyethylene glycol (PEG and mannitol, and salinity stress. The transgenic plants also showed enhanced tolerance to methyl-viologen (MV induced oxidative stress. Reduced levels of reactive oxygen species (ROS and ROS-induced damage were noticed in pot grown transgenic lines under water-deficit and natural high light conditions. Root growth under stress and recovery growth after stress alleviation was more in transgenic plants. Many stress-responsive genes were found to be up-regulated in transgenic lines expressing EcNAC1. Our results suggest that EcNAC1 overexpression confers tolerance against abiotic stress in susceptible species, tobacco.

TN-68 Spent Fuel Transport Cask Analytical Evaluation for Drop Events

International Nuclear Information System (INIS)

Shah, M.J.; Klymyshyn, Nicholas A.; Adkins, Harold E.; Koeppel, Brian J.

2007-01-01

The U.S. Nuclear Regulatory Commission (NRC) is responsible for licensing commercial spent nuclear fuel transported in casks certified by NRC under the Code of Federal Regulations (10 CFR), Title 10, Part 71 (1). Both the International Atomic Energy Agency regulations for transporting radioactive materials (2, paragraph 727), and 10 CFR 71.73 require casks to be evaluated for hypothetical accident conditions, which includes a 9-meter (m) (30-ft) drop-impact event onto a flat, essentially unyielding, horizontal surface, in the most damaging orientation. This paper examines the behavior of one of the NRC certified transportation casks, the TN-68 (3), for drop-impact events. The specific area examined is the behavior of the bolted connections in the cask body and the closure lid, which are significantly loaded during the hypothetical drop-impact event. Analytical work to evaluate the NRC-certified TN-68 spent fuel transport cask (3) for a 9-m (30-ft) drop-impact event on a flat, unyielding, horizontal surface, was performed using the ANSYS (4) and LS DYNA (5) finite-element analysis codes. The models were sufficiently detailed, in the areas of bolt closure interfaces and containment boundaries, to evaluate the structural integrity of the bolted connections under 9-m (30-ft) free-drop hypothetical accident conditions, as specified in 10 CFR 71.73. Evaluation of the cask for puncture, caused by a free drop through a distance of 1-m (40-in.) onto a mild steel bar mounted on a flat, essentially unyielding, horizontal surface, required by 10 CFR 71.73, was not included in the current work, and will have to be addressed in the future. Based on the analyses performed to date, it is concluded that, even though brief separation of the flange and the lid surfaces may occur under some conditions, the seals would close at the end of the drop events, because the materials remain elastic during the duration of the event

Modulation of biosynthesis and regulatory action of 24(S),25-epoxycholesterol (S-EC) in cultured cells by progesterone (PG)

International Nuclear Information System (INIS)

Panini, S.R.; Gupta, A.K.; Sexton, R.C.; Parish, E.J.; Rudney, H.

1987-01-01

Treatment of IEC-6 cells with PG caused a strong inhibition of cholesterol biosynthesis at the level of desmosterol reductase. In addition, two new products were observed in PG-treated cells. The first compound was designated as cholesta-5,7,24-trien-3β-ol based on its HPLC chromatographic properties. The second compound was identified as S-EC based on (1) a comparison of its chromatographic properties with those of authentic EC and (2) by its conversion to 25-hydroxycholesterol (HC) upon reduction with LiAlH 4 . In spite of cellular accumulation of S-EC in the presence of PG, the activity of HMG-CoA reductase (HMGR) which is known to be sensitive to oxysterols, was elevated rather than suppressed. On the other hand, when PG-treated cells were refed fresh medium without PG, HMGR activity was suppressed. Exogenous S-EC was a potent suppressor of HMGR in untreated IEC-6 cells. Suppression of HMGR by S-EC but not by HC could be prevented by progesterone. Exogenous [ 3 H]S-EC was not metabolized by IEC-6 cells. These results support the hypothesis that S-EC plays a normal regulatory role in sterol biosynthesis and indicate that enhanced S-EC synthesis observed in the presence of PG may be due to interference with this regulatory action

Green digital signage using nanoparticle embedded narrow-gap field sequential TN-LCDs

Science.gov (United States)

Kobayashi, Shunsuke; Shiraishi, Yukihide; Sawai, Hiroya; Toshima, Naoki; Okita, Masaya; Takeuchi, Kiyofumi; Takatsu, Haruyoshi

2012-03-01

We have fabricated field sequential color (FSC)-LCDs using cells and modules of narrow-gap TN-LCDs with and without doping the nanoparticles of PCyD-ZrO2 and AF-SiO2. It is shown that the FSC-LCD exhibits a high optical efficiency of OE=4.5 that is defined as OE=[Luminance]/[W/m2]=(cd/W). This figure may provide us a good reference or to clear the Energy Star Program Version 5-3 that issues a guideline: LCD with 50 inch on the diagonal consumes the energy of 108W. Through this research it is claimed that our FSC=LCD may be a novel green digital signage.

Inter-comparison of NIOSH and IMPROVE protocols for OC and EC determination: implications for inter-protocol data conversion

Science.gov (United States)

Wu, Cheng; Huang, X. H. Hilda; Ng, Wai Man; Griffith, Stephen M.; Zhen Yu, Jian

2016-09-01

Organic carbon (OC) and elemental carbon (EC) are operationally defined by analytical methods. As a result, OC and EC measurements are protocol dependent, leading to uncertainties in their quantification. In this study, more than 1300 Hong Kong samples were analyzed using both National Institute for Occupational Safety and Health (NIOSH) thermal optical transmittance (TOT) and Interagency Monitoring of Protected Visual Environment (IMPROVE) thermal optical reflectance (TOR) protocols to explore the cause of EC disagreement between the two protocols. EC discrepancy mainly (83 %) arises from a difference in peak inert mode temperature, which determines the allocation of OC4NSH, while the rest (17 %) is attributed to a difference in the optical method (transmittance vs. reflectance) applied for the charring correction. Evidence shows that the magnitude of the EC discrepancy is positively correlated with the intensity of the biomass burning signal, whereby biomass burning increases the fraction of OC4NSH and widens the disagreement in the inter-protocol EC determination. It is also found that the EC discrepancy is positively correlated with the abundance of metal oxide in the samples. Two approaches (M1 and M2) that translate NIOSH TOT OC and EC data into IMPROVE TOR OC and EC data are proposed. M1 uses direct relationship between ECNSH_TOT and ECIMP_TOR for reconstruction: M1 : ECIMP_TOR = a × ECNSH_TOT + b; while M2 deconstructs ECIMP_TOR into several terms based on analysis principles and applies regression only on the unknown terms: M2 : ECIMP_TOR = AECNSH + OC4NSH - (a × PCNSH_TOR + b), where AECNSH, apparent EC by the NIOSH protocol, is the carbon that evolves in the He-O2 analysis stage, OC4NSH is the carbon that evolves at the fourth temperature step of the pure helium analysis stage of NIOSH, and PCNSH_TOR is the pyrolyzed carbon as determined by the NIOSH protocol. The implementation of M1 to all urban site data (without considering seasonal specificity

EC tells Bonn let in UK coal

Energy Technology Data Exchange (ETDEWEB)

1992-06-23

The European Commission has told the German federal government to open the door for coal imports from other EC member countries. As an initial step, the Commission is suggesting that some of the power station coal which was to be sourced from German stockpiles under the November 1991 agreement between Rurhkohle AG, the state mining company and the generators, be supplied by other member states such as the UK. The implications of this move for the German coal industry are discussed. 2 tabs.

'Test n Treat (TnT)': a cluster-randomised feasibility trial of frequent, rapid-testing and same-day, on-site treatment to reduce rates of chlamydia in high-risk further education college students: statistical analysis plan.

Science.gov (United States)

Phillips, Rachel; Oakeshott, Pippa; Kerry-Barnard, Sarah; Reid, Fiona

2018-06-05

There are high rates of sexually transmitted infections (STIs) in ethnically diverse, sexually active students aged 16-24 years attending London further education (FE) colleges. However, uptake of chlamydia screening remains low. The TnT study aims to assess the feasibility of conducting a future trial in FE colleges to investigate if frequent, rapid, on-site testing and treatment (TnT) reduces chlamydia rates. This article presents the statistical analysis plan for the main study publication as approved and signed off by the Trial Management Group prior to the first data extraction for the final report. TnT is a cluster-randomised feasibility trial conducted over 7 months with parallel qualitative and economic assessments. Colleges will be randomly allocated into the intervention (TnT) or the control group (no TnT). Six FE colleges in London will be included. At each college for 2 days, 80 consecutive sexually active students aged 16-24 years (total 480 students across all six colleges) will be recruited from public areas and asked to provide baseline samples. One and 4 months after recruitment intervention colleges will be visited on two consecutive days by the TnT team where participating students will be texted and invited to come for same-day, on-site, rapid chlamydia testing and, if positive, treatment. Participants in the control colleges will receive 'thank you' texts 1 and 4 months after recruitment. Seven months after recruitment, participants from both groups will be invited to complete questionnaires and provide samples for TnT. All samples will be tested, and same-day treatment offered to participants with positive results. Key feasibility outcomes include: recruitment rates, testing and treatment uptake rates (at 1 and 4 months) and follow-up rates (at 7 months). ISRCTN 58038795 . Registered on 31 August 2016.

GPM GROUND VALIDATION ENVIRONMENT CANADA (EC) VAISALA CEILOMETER GCPEX V1

Data.gov (United States)

National Aeronautics and Space Administration — The GPM Ground Validation Environment Canada (EC) VAISALA Ceilometer GCPEx dataset was collected during the GPM Cold-season Precipitation Experiment (GCPEx) in...

Technique charts for EC film: direct optical measurements to account for the effects of X-ray scatter

International Nuclear Information System (INIS)

Munro, Peter; Jordan, Kevin; Lewis, Craig; Heerema, Tim

2001-01-01

Purpose: To develop a method of measuring technique charts for enhanced contrast (EC) film, to demonstrate how X-ray scatter changes the response of EC film, and to generate technique charts for general use. Methods and Materials: We have developed a 'digital cassette' - consisting of a metal plate/phosphor screen, a light guide, a photodiode sensor, and an electrometer - that can be used to measure the light generated in the phosphor screen of the film cassette. In turn, these measurements can be used to generate technique charts for EC film. The digital cassette has been used to measure technique charts for 4-MV and 6-MV X-ray beams for a variety of different phantom thicknesses, field sizes, and phantom-to-cassette air gaps. Results and Discussion: We have observed that the signals generated in an ionization chamber located 9.4 cm behind a 30-cm-thick water-equivalent phantom increase by a factor of 1.9 when the field size is increased from 4x4 cm 2 to 40x40 cm 2 when irradiated by a 6-MV X-ray beam. However, the change in EC film response is a factor of 3.5 under the same conditions. Irradiations to optimally expose the EC film predicted by the digital cassette differ by up to 82% compared to those predicted by ion chamber measurements. Nevertheless, the technique charts measured using the digital cassette predict the response of the EC film to ±0.2 optical density. The overresponse of the EC film is most likely due to low-energy scattered photons, which interact with the high atomic number (Z=64) phosphor screen of the enhanced contrast localization cassette. Therefore, simple solutions, such as placing a high atomic number material above the enhanced contrast localization cassette, can reduce this contribution by scattered photons to the signal generated in the cassettes. Conclusions: We have developed a digital cassette that can make more accurate measurements of the technique charts for EC films. Our measurements show that under some conditions, X

Uncertainty in CH4 and N2O emission estimates from a managed fen meadow using EC measurements

International Nuclear Information System (INIS)

Kroon, P.S.; Hensen, A.; Van 't Veen, W.H.; Vermeulen, A.T.; Jonker, H.

2009-02-01

The overall uncertainty in annual flux estimates derived from chamber measurements may be as high as 50% due to the temporal and spatial variability in the fluxes. As even a large number of chamber plots still cover typically less than 1% of the total field area, the field-scale integrated emission necessarily remains a matter of speculation. High frequency micrometeorological methods are a good option for obtaining integrated estimates on a hectare scale with a continuous coverage in time. Instrumentation is now becoming available that meets the requirements for CH4 and N2O eddy covariance (EC) measurements. A system consisting of a quantum cascade laser (QCL) spectrometer and a sonic anemometer has recently been proven to be suitable for performing EC measurements. This study analyses the EC flux measurements of CH4 and N2O and its corrections, like calibration, Webb-correction, and corrections for high and low frequency losses, and assesses the magnitude of the uncertainties associated with the precision of the measurement instruments, measurement set-up and the methodology. The uncertainty of one single EC flux measurement, a daily, monthly and 3-monthly average EC flux is estimated. In addition, the cumulative emission of C-CH4 and N-N2O and their uncertainties are determined over several fertilizing events at a dairy farm site in the Netherlands. These fertilizing events are selected from the continuously EC flux measurements from August 2006 to September 2008. The EC flux uncertainties are compared by the overall uncertainty in annual flux estimates derived from chamber measurements. It will be shown that EC flux measurements can decrease the overall uncertainty in annual flux estimates

Uncertainty in CH4 and N2O emission estimates from a managed fen meadow using EC measurements

Energy Technology Data Exchange (ETDEWEB)

Kroon, P.S.; Hensen, A.; Van ' t Veen, W.H.; Vermeulen, A.T. [ECN Biomass, Coal and Environment, Petten (Netherlands); Jonker, H. [Delft University of Technology, Delft (Netherlands)

2009-02-15

The overall uncertainty in annual flux estimates derived from chamber measurements may be as high as 50% due to the temporal and spatial variability in the fluxes. As even a large number of chamber plots still cover typically less than 1% of the total field area, the field-scale integrated emission necessarily remains a matter of speculation. High frequency micrometeorological methods are a good option for obtaining integrated estimates on a hectare scale with a continuous coverage in time. Instrumentation is now becoming available that meets the requirements for CH4 and N2O eddy covariance (EC) measurements. A system consisting of a quantum cascade laser (QCL) spectrometer and a sonic anemometer has recently been proven to be suitable for performing EC measurements. This study analyses the EC flux measurements of CH4 and N2O and its corrections, like calibration, Webb-correction, and corrections for high and low frequency losses, and assesses the magnitude of the uncertainties associated with the precision of the measurement instruments, measurement set-up and the methodology. The uncertainty of one single EC flux measurement, a daily, monthly and 3-monthly average EC flux is estimated. In addition, the cumulative emission of C-CH4 and N-N2O and their uncertainties are determined over several fertilizing events at a dairy farm site in the Netherlands. These fertilizing events are selected from the continuously EC flux measurements from August 2006 to September 2008. The EC flux uncertainties are compared by the overall uncertainty in annual flux estimates derived from chamber measurements. It will be shown that EC flux measurements can decrease the overall uncertainty in annual flux estimates.

The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology.

Science.gov (United States)

Armakolas, Nikolaos; Armakolas, Athanasios; Antonopoulos, Athanasios; Dimakakos, Andreas; Stathaki, Martha; Koutsilieris, Michael

2016-12-01

Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

socio-ec(h)o: Ambient Intelligence and Gameplay

OpenAIRE

Wakkary, Ron

2005-01-01

The socio-ec(h)o project aims to research a generalized ambient intelligent software platform and design models for responsive environments based on the concept of ambient intelligent "ecologies" and group gameplay. The benefits of the research include a software-architecture, ambient intelligence inference engine, and interaction design models for gameplay and responsive environments. The paper will discuss the results of our prototypes for games in responsive environments. These prototypes ...

Spatial and seasonal distribution of carbon, nitrogen, phosphorus, and sulfur and their ecological stoichiometry in wetland soils along a water and salt gradient in the Yellow River Delta, China

Science.gov (United States)

Lu, Qiongqiong; Bai, Junhong; Zhang, Guangliang; Zhao, Qingqing; Wu, Jianjun

2018-04-01

Top soils (0-10 cm) were collected in three sampling belts during four seasons in 2014, including bare land (HN1), Calamagrostis epigeios (HN2), Typha orientalis (HN3), Phragmites australis (HN4), Tamarix chinensis (HN5) and Suaeda salsa (HN6) along a water and salinity gradient in the Yellow River Delta, China. Soil organic carbon (SOC), total nitrogen (TN), total phosphorous (TP), total sulfur (TS) and their ecological stoichiometry were measured to investigate their seasonal and horizontal distribution patterns, as well as their important influencing factors such as electric conductivity (EC) and water content (WC). Our results showed that the contents of SOC and TN exhibited similar changing tendency along the water and salinity gradient. The TP contents followed the order HN5 ≈ HN2 > HN3 ≈ HN6 > HN4 > HN1. TS levels generally increased with increasing salinity from HN1 to HN6. The higher levels of SOC and TP were mostly observed in October and August, respectively, while the seasonal variations in TN were heterogeneous under different plant covers. TS contents were lower in August compared with other sampling periods except for HN4. The mean values of the C/N, C/P and C/S ratios along a water-salinity gradient ranged from 26 to 72, 20 to 74, and 61 to 292, respectively. Generally, higher C/P ratios were observed in sampling sites with plant covers in October expect for HN1, whereas they were lower in January or August. SOC, TN and TP were significantly positively correlated with soil organic matter (SOM), silt, WC and cation exchange capacity (CEC) (p 0.05). Bulk density (BD) had a great influence on C/N ratio, C/P ratio were mainly effected by SOM, EC and silt, while C/S ratio showed a significant negative correlation with BD, EC, K+, Na+, and Mg2+ (p < 0.05).

77 FR 59573 - Proposed Amendment of Class D and E Airspace; Tri-Cities, TN; Revocation of Class E Airspace; Tri...

Science.gov (United States)

2012-09-28

... at Hawkins County Airport, Rogersville, TN, and Virginia Highlands Airport, Abington, VA. The Tri... separation of existing Class E airspace surrounding Virginia Highlands Airport, Abingdon, VA, and Hawkins... publication, the FAA reassessed the proposal to show the separation of Hawkins County Airport, and Virginia...

[Characteristics and sources apportionment of OC and EC in PM1.1 from Nanjing].

Science.gov (United States)

Jiang, Wen-juan; Guo, Zhao-bing; Liu, Feng-ling; Rui, Mao-ling; Shi, Lei; Zeng, Gang; Guo, Zi-yan

2015-03-01

The concentrations of OC and EC in PM1.1 collected from Nanshi (NS) and Nanhua (NH) in 2011 were analyzed using DRI Model 2001A Thermal Optical Carbon Analyzer. In addition, source apportionment was simultaneously evaluated. The results showed that the annual average concentrations of OC and EC in PM1.1 were 10. 10 μg x m(-3) and 2.52 μg x m(-3) in NS area, and 11.22 μg x m(-3) and 3.12 μg x m(-3) in NH area, respectively. This result indicated that OC and EC pollution in NH was more serious than that in NS area. Meanwhile, the concentrations of OC and EC in winter and spring were obviously higher compared to those in summer in these two sampling sites, which was mainly ascribed to the increased coal combustion and the unfavorable emission condition of air pollutants in summer and spring. We noted that the SOC/TOC value was the highest in summer and the lowest in winter. In addition, the SOC concentration was observed to show a positive correlation with ozone concentrations, which indicated that the photochemical reaction was a main way of SOC formation in autumn.

Acute and repeated ECS treatment increases CRF, POMC and PENK gene expression in selected regions of the rat hypothalamus.

Science.gov (United States)

Garcia-Garcia, L; Llewellyn-Jones, V; Fernandez Fernandez, I; Fuentes, J A; Manzanares, J

1998-01-05

The purpose of this study was to investigate the effects of acute and repeated electroconvulsive shock (ECS) on corticotropin releasing factor (CRF), proopiomelanocortin (POMC) and proenkephalin (PENK) gene expression in selected regions of the brain and pituitary of the rat. Acute ECS increased CRF gene expression in the paraventricular nucleus (PVN) by 20%, an effect that was further enhanced to 38% when rats received repeated ECS treatment. Acute and repeated ECS increased POMC gene expression in the arcuate nucleus (ARC) by 49-59% but failed to alter these mRNA levels in the anterior lobe (AL) of the pituitary gland. PENK gene expression was increased by 35% in the nucleus accumbens (NA) and by 180% the ventromedial nucleus (VMN) after acute or repeated ECS treatment but no significant changes were found in the PVN or striatum (ST). Taken together, these results indicate a differential CRF and opioid gene expression regulation after acute or repeated ECS treatment that may be relevant to their therapeutic or side effects in depression.

Cancer cells cause vascular endothelial cell (vEC) retraction via 12(S)HETE secretion; the possible role of cancer cell derived microparticle.

Science.gov (United States)

Uchide, Keiji; Sakon, Masato; Ariyoshi, Hideo; Nakamori, Syouji; Tokunaga, Masaru; Monden, Morito

2007-02-01

Cancer cell mediated vascular endothelial cell (vEC) retraction plays a pivotal role in cancer metastasis. The aim of this study is to clarify the biochemical character of vEC retraction factor derived from human breast cancer cell line, MCF-7. In order to estimate vEC retracting activity, transwell chamber assay system was employed. We first tested the effects of trypsin digestion as well as lipid extraction of culture medium (CM). Trypsin digestion of CM resulted in approximately 40% loss of vEC retracting activity and lipid extraction of CM by Brigh and Dyer methods recovered approximately 60% of vEC retracting activity, suggesting that approximately 60% of vEC retracting activity in MCF-7 derived CM is due to lipid. Although Nordihydroguaiaretic acid (NDGA), the specific lipoxygenase inhibitor, suppressed vEC retracting activity in CM, Acetyl salicylic acid (ASA), a specific cyclooxygenase inhibitor, did not affect the activity, suggesting that lipid exerting vEC retracting activity in CM belongs to lipoxygenase mediated arachidonate metabolites. Thin layer chromatography clearly demonstrated that Rf value of lipid vEC retracting factor in CM is identical to 12HETE. Authentic 12(S)HETE, but not 12(R)HETE, showed vEC retracting activity. After the ultracentrifugation of CM, most lipid vEC retracting activity was recovered from the pellet fraction, and flow cytometric analysis using specific antibody against 12(S)HETE clearly showed the association of 12(S)HETE with small particle in CM. These findings suggested the principal involvement of 12(S)HETE in cancer cell derived microparticles in cancer cell mediated vEC retraction.

哈氏弧菌EcGY020401优化培养%Optimization Culture of Vibrio harveyi EcGY020401

Institute of Scientific and Technical Information of China (English)

陶家发; 赖迎迢; 潘厚军; 石存斌; 吴淑勤

2010-01-01

目的:为规模化制备弧菌疫苗提供相关数据.方法:利用摇瓶和小型发酵罐培养,通过平板计数测定培养菌液的活菌数.结果:哈氏弧菌(Vibrio harveyi)EcGY020401株最适盐度为20～25g/L,合适的pH为7.5～7.7,葡萄糖浓度最适浓度为2～5g/L,用TSB优化培养基:胰蛋白胨5g/L、蛋白胨15g/L、大豆蛋白胨3g/L、酵母膏1g/L、葡萄糖4g/L、磷酸氢二钾5g/L、氯化钠15g/L、pH 7.5,培养EcGY020401菌株,可达2.95×1010 cfu/mL;小型发酵罐培养,10h可达到生长最大值,菌液浓度为3.46×1010cfu/mL 结论:用优化TSB培养基,采用发酵罐培养弧菌,可降低成本,提搞培养效率.

Characterization of Tn3000, a Transposon Responsible for blaNDM-1 Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India.

Science.gov (United States)

Campos, Juliana Coutinho; da Silva, Maria José Félix; dos Santos, Paulo Roberto Nascimento; Barros, Elaine Menezes; Pereira, Mayne de Oliveira; Seco, Bruna Mara Silva; Magagnin, Cibele Massotti; Leiroz, Leonardo Kalab; de Oliveira, Théo Gremen Mimary; de Faria-Júnior, Célio; Cerdeira, Louise Teixeira; Barth, Afonso Luís; Sampaio, Suely Carlos Ferreira; Zavascki, Alexandre Prehn; Poirel, Laurent; Sampaio, Jorge Luiz Mello

2015-12-01

In Enterobacteriaceae, the blaNDM genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing Escherichia coli and Enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the blaNDM-1 gene, one from each strain, showed that they belonged to incompatibility groups IncFIIK and IncX3 and harbored a novel transposon named Tn3000. Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the blaNDM-1 gene may be transmitted by Tn3000 in different parts of the world. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Consumption of food in EC countries

International Nuclear Information System (INIS)

Ven-Breken, T.J. van de; Brenot, J.; Bonnefous, S.; Noordijk, H.; Leenhouts, H.P.

1990-08-01

Annual consumption of 10 classes of food and drink is reported for the total population of each EC-country. National food consumption data are generalized by distinguishing groups of countries with similar diet. Group 1: UK and Ireland (low consumption of fruit, high consumption of potatoes and fresh dairy products). Group 2: Italy and Greece (high consumption of cereals, vegetables and fruit, low consumption of fresh dairy products). Group 3: France, Belgium, Luxembourg, Netherlands, FRG and Spain (intermediate consumption of most foodstuffs). Portugal and Denmark could not be classified in any group. Changes in food consumption related to differences in age, sex, social class, regional habits and level of urbanisation are reported.In some cases, variation of annual food consumption over the different seasons on the relative contribution of food from local origin to the total diet, could be estimated. Differences of region, age and level of urbanisation appear to have the largest influence on consumed amounts. As for age, the values for the different age-groups range from 50 to 80 percent of the adult diet. Regional consumption may diverge from 70-130 percent of the average national consumption, with values of 200 percent for potatoes and fruit. Consumption in urban areas compared with the entire country diverges from 70-100 percent. In rural areas the values diverge from 100-140 percent. Self-support of vegetables and milk seems to be important for most countries. Of the other products, self-support of wheat and cheese is only of importance in the south of the EC. When combining the effects of the different factors, a range of consumed amounts for specific population groups of 50 to 200 percent of the average national consumption was determined. (author). 38 refs.; 13 figs.; 75 tabs

annot8r: GO, EC and KEGG annotation of EST datasets

Directory of Open Access Journals (Sweden)

Schmid Ralf

2008-04-01

Full Text Available Abstract Background The expressed sequence tag (EST methodology is an attractive option for the generation of sequence data for species for which no completely sequenced genome is available. The annotation and comparative analysis of such datasets poses a formidable challenge for research groups that do not have the bioinformatics infrastructure of major genome sequencing centres. Therefore, there is a need for user-friendly tools to facilitate the annotation of non-model species EST datasets with well-defined ontologies that enable meaningful cross-species comparisons. To address this, we have developed annot8r, a platform for the rapid annotation of EST datasets with GO-terms, EC-numbers and KEGG-pathways. Results annot8r automatically downloads all files relevant for the annotation process and generates a reference database that stores UniProt entries, their associated Gene Ontology (GO, Enzyme Commission (EC and Kyoto Encyclopaedia of Genes and Genomes (KEGG annotation and additional relevant data. For each of GO, EC and KEGG, annot8r extracts a specific sequence subset from the UniProt dataset based on the information stored in the reference database. These three subsets are then formatted for BLAST searches. The user provides the protein or nucleotide sequences to be annotated and annot8r runs BLAST searches against these three subsets. The BLAST results are parsed and the corresponding annotations retrieved from the reference database. The annotations are saved both as flat files and also in a relational postgreSQL results database to facilitate more advanced searches within the results. annot8r is integrated with the PartiGene suite of EST analysis tools. Conclusion annot8r is a tool that assigns GO, EC and KEGG annotations for data sets resulting from EST sequencing projects both rapidly and efficiently. The benefits of an underlying relational database, flexibility and the ease of use of the program make it ideally suited for non

A new verification film system for routine quality control of radiation fields: Kodak EC-L.

Science.gov (United States)

Hermann, A; Bratengeier, K; Priske, A; Flentje, M

2000-06-01

The use of modern irradiation techniques requires better verification films for determining set-up deviations and patient movements during the course of radiation treatment. This is an investigation of the image quality and time requirement of a new verification film system compared to a conventional portal film system. For conventional verifications we used Agfa Curix HT 1000 films which were compared to the new Kodak EC-L film system. 344 Agfa Curix HT 1000 and 381 Kodak EC-L portal films of different tumor sites (prostate, rectum, head and neck) were visually judged on a light box by 2 experienced physicians. Subjective judgement of image quality, masking of films and time requirement were checked. In this investigation 68% of 175 Kodak EC-L ap/pa-films were judged "good", only 18% were classified "moderate" or "poor" 14%, but only 22% of 173 conventional ap/pa verification films (Agfa Curix HT 1000) were judged to be "good". The image quality, detail perception and time required for film inspection of the new Kodak EC-L film system was significantly improved when compared with standard portal films. They could be read more accurately and the detection of set-up deviation was facilitated.

Studies with the EC-Earth seamless Earth system prediction model

NARCIS (Netherlands)

Hazeleger, W.; Bintanja, R.

2012-01-01

EC-Earth is a new Earth System Model (ESM) based on the operational seasonal forecast system of the European Centre for Medium-Range Weather Forecasts (ECMWF). Climate and weather forecasting applications share a common ancestry and are build on the same physical principles. The emerging concept of

Impurity analysis in EC-99mTC radiotracer using chromatographic techniques

International Nuclear Information System (INIS)

Almeida, E.V.; Fukumori, N.T.O.; Mengatti, J.; Silva, C.P.G.; Matsuda, M.M.N.

2008-01-01

The objective of this study was to develop two chromatographic methods of impurity analysis in radiotracer 99m Tc-EC: the Thin Layer Chromatography (TLC) and the High Performance Liquid Chromatography Reversed Phase (HPLC-RP)

A large inversion in the linear chromosome of Streptomyces griseus caused by replicative transposition of a new Tn3 family transposon.

Science.gov (United States)

Murata, M; Uchida, T; Yang, Y; Lezhava, A; Kinashi, H

2011-04-01

We have comprehensively analyzed the linear chromosomes of Streptomyces griseus mutants constructed and kept in our laboratory. During this study, macrorestriction analysis of AseI and DraI fragments of mutant 402-2 suggested a large chromosomal inversion. The junctions of chromosomal inversion were cloned and sequenced and compared with the corresponding target sequences in the parent strain 2247. Consequently, a transposon-involved mechanism was revealed. Namely, a transposon originally located at the left target site was replicatively transposed to the right target site in an inverted direction, which generated a second copy and at the same time caused a 2.5-Mb chromosomal inversion. The involved transposon named TnSGR was grouped into a new subfamily of the resolvase-encoding Tn3 family transposons based on its gene organization. At the end, terminal diversity of S. griseus chromosomes is discussed by comparing the sequences of strains 2247 and IFO13350.

Serum antibodies and DNA indicate a high prevalence of equine papillomavirus 2 (EcPV2) among horses in Switzerland.

Science.gov (United States)

Fischer, Nina M; Favrot, Claude; Birkmann, Katharina; Jackson, Michele; Schwarzwald, Colin C; Müller, Martin; Tobler, Kurt; Geisseler, Marco; Lange, Christian E

2014-06-01

The DNA of equine papillomavirus type 2 (EcPV2) is consistently found in equine papillomas and squamous cell carcinomas, indicating a causal association of EcPV2 in the pathogenesis of these tumours; however, little is known about the prevalence of this virus. The aim of this study was to determine the geno- and seroprevalence of EcPV2 in clinically healthy horses in Switzerland. Fifty horses presented to the equine department of the university clinic, displaying no skin or mucous membrane lesions or severe signs of other diseases, were sampled. Cytobrush samples from the penis or vulva and serum samples were collected. To determine the genoprevalence of EcPV2, DNA was extracted from cytobrush samples and tested for viral DNA with a PCR assay amplifying a 338 bp fragment of the E7/E1 region of the viral genome. Seroprevalence was tested using an enzyme-linked immunosorbent assay aimed to detect antibodies against the major capsid protein (L1) of EcPV2. In five of 50 horses (10%), EcPV2-specific DNA was amplified but no antibodies could be detected, whereas in 14 of 50 horses (28%), antibodies against EcPV2 but no DNA were demonstrated. Both antibodies and viral DNA were detected in four of 50 horses (8%). Neither antibodies nor viral DNA were found in 27 of 50 horses (54%). The seroprevalence suggests that EcPV2 is prevalent in the Swiss equine population, while the genoprevalence indicates that currently ongoing infections are less common. The discrepancy between geno- and seroprevalence probably indicates different stages of infection in the tested cohort. © 2014 ESVD and ACVD.

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing

DEFF Research Database (Denmark)

Madsen, Caroline B; Lavrsen, Kirstine; Steentoft, Catharina

2013-01-01

are recognized as cancer associated truncated glycans, and are expressed in many adenocarcinomas, e.g. breast- and pancreatic cancer cells. To investigate the role of the cancer associated glycan truncations in immune-mediated killing we created glyco-engineered breast- and pancreatic cancer cells expressing...... only the shortest possible mucin-like glycans (Tn and STn). Glyco-engineering was performed by zinc finger nuclease (ZFN) knockout (KO) of the Core 1 enzyme chaperone COSMC, thereby preventing glycan elongation beyond the initial GalNAc residue in O-linked glycans. We find that COSMC KO in the breast...

77 FR 21505 - Proposed Amendment of Class D and E Airspace; Blountville, TN, and Revocation of Class E Airspace...

Science.gov (United States)

2012-04-10

... Airport, VA (Lat. 36[deg]41'14'' N., long. 82[deg]02'00'' W.) Rogersville, Hawkins County Airport, TN (Lat... Highlands Airport and within a 7-mile radius of Hawkins County Airport, and within 7 miles each side of Runway 07/25 centerline, extending from the 7-mile radius to 12 miles east of Hawkins County Airport...

GPM GROUND VALIDATION ENVIRONMENT CANADA (EC) MANUAL PRECIPITATION MEASUREMENTS GCPEX V1

Data.gov (United States)

National Aeronautics and Space Administration — The GPM Ground Validation Environment Canada (EC) Manual Precipitation Measurements GCPEx dataset was collected during the GPM Cold-season Precipitation Experiment...

Translational coupling in Escherichia coli of a heterologous Bacillus subtilis-Escherichia coli gene fusion.

OpenAIRE

Zaghloul, T I; Doi, R H

1986-01-01

The efficient expression in Escherichia coli of the Tn9-derived chloramphenicol acetyltransferase (EC 2.3.1.28) gene fused distal to the promoter and N terminus of the Bacillus subtilis aprA gene was dependent on the initiation of translation from the ribosome-binding site in the aprA gene.

ECONOMIC AND LEGAL ASPECTS OF THE PLANNED DAMAGES ACTIONS FOR THE BREACHES OF EC ANTITRUST LAW

Directory of Open Access Journals (Sweden)

Elena Isac

2010-09-01

Full Text Available This paper investigates the planned damages actions for breaches of EC antitrust law in order to assess their impact on consumer welfare. It first examines the current legal situation and concurs that the European Union needs to regulate damages actions for breaches of EC antitrust law so that a higher number of consumers could be compensated for their losses. This paper then discusses the main legal provisions proposed by the Commission in the Green and in the White paper on damages actions for breaches of EC antitrust law. The analysis of these proposed legal provisions is done using arguments specific to the economic analysis of law. It is demonstrated that most of these proposed legal provisions will enhance consumer welfare but that there are also proposed legal provisions which will damage consumer welfare. The paper concludes that the planned damages actions for breaches of the EC law will be an improvement compared to the current situation. However, the Commission should amend some of the proposed legal provisions in order to help consumers further.

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells

DEFF Research Database (Denmark)

Posey, Avery D; Clausen, Henrik; June, Carl H

2016-01-01

Genetically modified T cells expressing chimeric antigen receptors (CARs) demonstrate potent clinical antitumor effects in a variety of blood cancers. However, clinical activity in solid tumors has been disappointing and toxicity has been a serious concern (Lamers et al., 2013; Morgan et al., 2010......). We recently found that a CAR composed of a scFv antibody fragment specific for the Tn-glycoform of MUC1 had potent activity in preclinical models of blood cancer and adenocarcinoma (Posey et al., 2016)....

Q and A. Why the EC's PINC has failed Europe's nuclear industry

Energy Technology Data Exchange (ETDEWEB)

Kraev, Kamen [NucNet, Brussels (Belgium)

2016-12-15

The European Economic and Social Committee (EESC) has called for a more comprehensive strategy to be incorporated in a revised version of the European Commission's (EC) Illustrative Programme for Nuclear Energy (PINC). EESC member Brian Curtis tells NucNet why the PINC has failed to address key issues for nuclear and why he believes the EC has become side-tracked by renewables. The EESC is a consultative body which represents the interests of civil society organisations and stakeholders at the EU. Its opinions are forwarded to the EC, the European Council, and the European Parliament and are considered in the EU's decision-making process. Brian Curtis was rapporteur on the committee's opinion paper.

Towards Coleoptera-specific high-throughput screening systems for compounds with ecdysone activity: development of EcR reporter assays using weevil (Anthonomus grandis)-derived cell lines and in silico analysis of ligand binding to A. grandis EcR ligand-binding pocket.

Science.gov (United States)

Soin, Thomas; Iga, Masatoshi; Swevers, Luc; Rougé, Pierre; Janssen, Colin R; Smagghe, Guy

2009-08-01

Molting in insects is regulated by ecdysteroids and juvenile hormones. Several synthetic non-steroidal ecdysone agonists are on the market as insecticides. These ecdysone agonists are dibenzoylhydrazine (DBH) analogue compounds that manifest their toxicity via interaction with the ecdysone receptor (EcR). Of the four commercial available ecdysone agonists, three (tebufenozide, methoxyfenozide and chromafenozide) are highly lepidopteran specific, one (halofenozide) is used to control coleopteran and lepidopteran insects in turf and ornamentals. However, compared to the very high binding affinity of these DBH analogues to lepidopteran EcRs, halofenozide has a low binding affinity for coleopteran EcRs. For the discovery of ecdysone agonists that target non-lepidopteran insect groups, efficient screening systems that are based on the activation of the EcR are needed. We report here the development and evaluation of two coleopteran-specific reporter-based screening systems to discover and evaluate ecdysone agonists. The screening systems are based on the cell lines BRL-AG-3A and BRL-AG-3C that are derived from the weevil Anthonomus grandis, which can be efficiently transduced with an EcR reporter cassette for evaluation of induction of reporter activity by ecdysone agonists. We also cloned the almost full length coding sequence of EcR expressed in the cell line BRL-AG-3C and used it to make an initial in silico 3D-model of its ligand-binding pocket docked with ponasterone A and tebufenozide.

Integration of IC/EC systems in ITER

International Nuclear Information System (INIS)

Gassmann, T.; Beaumont, B.; Baruah, U.K.; Bonicelli, T.; Chiocchio, S.; Cox, D.; Darbos, C.; Decamps, H.; Denisov, G.; Henderson, M.; Kazarian, F.; Lamalle, P.U.; Mukherjee, A.; Rasmussen, D.; Saibene, G.; Sartori, R.; Sakamoto, K.; Tanga, A.

2010-01-01

The RF heating and current drive (H and CD) systems that are to be installed in ITER during the construction phase, are the electron cyclotron (EC) and ion cyclotron (IC) systems. They are complex assemblies of high voltage power supplies (HVPS), RF generators, transmission lines and antennas. Their design and integration are constrained by many interfaces, both internal, between the subsystems, and external, with the other ITER systems. In addition, some components must be compatible with a nuclear environment and are classified as Safety Important Component. This paper describes the processes implemented in ITER to ensure proper integration.

Renewables in Transport: Directive 2009/28/EC - Devils in its Details

International Nuclear Information System (INIS)

Wilkin, S.

2009-01-01

As part of the 3*20 targets reached in December 2008, the EC decided that the EU should, by 2020, source 20% of its Final Energy Consumption (FEC) renewably. Working towards this aim should in general contribute to the primary objective of reducing emissions, but there are two major issues with the implementation of the target in the Transport sector which run the risk of being irrelevant or even counterproductive. Firstly, the constraining stipulation that all Member States should source 10% of their Transport sector FEC renewably will be a struggle for some Member States to achieve, forcing them to invest large amounts of money which would be better spent elsewhere. Secondly, the relevant legislation gives unrepresentative weight to the benefits of Electric Vehicles (EVs), meaning that Member States which invest in EVs may give the illusion of having reached their national renewable targets without actually having done so. This paper is based on EC Directive 2009/28/EC (henceforth referred to as 'the Directive') and the National Renewable Energy Action Plans of Denmark, France, Germany, Italy, Spain, and the UK which were submitted in response. Each EU Member State has an individual target for the proportion of its FEC which is to come from renewable sources in 2020. The targets are based on the countries? existing renewable shares (as shown in Table 1 below) and their supposed capacity for improvement. Together, they give an average EU-wide target of 20% across the 27 Member States. (author)

CARACTERIZACIÓN DE IGYS ANTI-LECTINA DE Salvia bogotensis Y SU APLICACIÓN EN ESTUDIOS CITOQUÍMICOS PARA LA DETECCIÓN DEL ANTÍGENO TN

Directory of Open Access Journals (Sweden)

Nohora Vega

2010-02-01

Full Text Available Las inmunoglobulinas aisladas de la yema de huevo (IgY son muy utilizadas actualmente en diversos campos de las ciencias biológicas, dadas sus ventajas frente a las IgG séricas de mamíferos. En un trabajo previo establecimos las condiciones de obtención de IgY dirigidas contra la lectinas de Salvia bogotensis; su utilización en estudios inmunocitoquímicos requiere conocer sus principales características moleculares y las condiciones para la interacción IgY-lectina. La lectina de Salvia bogotensis (SBoL reconoce específicamente el antígeno Tn, marcador tumoral en muchos tipos de cáncer, pero se requieren herramientas adicionales para evidenciar esta interacción a nivel celular. Dada la disponibilidad de IgY anti-lectina de S. bogotensis, se realizó este trabajo con el objeto de caracterizar molecularmente estas IgY y evaluar su utilización en estudios inmunocitoquímicos para la detección del antígeno Tn en células tumorales. A las IgY purificadas se les determinó su punto isoeléctrico, peso molecular y contenido de carbohidratos. Para establecer la especificidad de interacción IgY-SBoL se obtuvieron lectinas homólogas y heterólogas y se ensayaron por ELLSA. La detección del antígeno Tn en las líneas celulares MCF-7 y HeLa con la lectina y las IgYs marcadas con biotina o peroxidasa se realizó por CELISA e inmunocitoquímica. Los resultados mostraron que los anticuerpos IgY anti-SBoL son una herramienta de una alta sensibilidad para los ensayos de reconocimiento específico del antígeno Tn.

Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells

DEFF Research Database (Denmark)

Napoletano, Chiara; Rughetti, Aurelia; Agervig Tarp, Mads P

2007-01-01

. This results in the expression of tumor-associated glycoforms and in MUC1 carrying the tumor-specific glycan Tn (GalNAcalpha1-O-Ser/Thr). Glycopeptides corresponding to three tandem repeats of MUC1, enzymatically glycosylated with 9 or 15 mol of GalNAc, were shown to specifically bind and to be internalized...... and ELISA done on subcellular fractions of iDCs showed that the Tn-MUC1 glycopeptides colocalized with HLA class I and II compartments after internalization. Importantly, although Tn-MUC1 recombinant protein was bound and internalized by MGL, the glycoprotein entered the HLA class II compartment......, but not the HLA class I pathway. These data indicate that MGL expressed on iDCs is an optimal receptor for the internalization of short GalNAcs carrying immunogens to be delivered into HLA class I and II compartments. Such glycopeptides therefore represent a new way of targeting the HLA class I and II pathways...

[Knockdown of NEDD9 inhibits the proliferation, invasion and migration of esophageal carcinoma EC109 cells].

Science.gov (United States)

Zhang, Wen; Li, Shaojun; Zhao, Yunlong; Guo, Nannan; Li, Yingjie

2016-12-01

Objective To observe the expression of the neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) in esophageal cancer, to investigate the impact of decreased expression of NEDD9 on invasion and migration, and to explicit the function of NEDD9 in EC109 human esophageal cancer cell line. Methods Immunohistochemical staining was used to detect the expression of NEDD9 in human esophageal cancer tissues and paracancerous normal tissues. RNA interfering (RNAi) was used to knockdown NEDD9 in EC109 cells. The interference efficiency was detected by reverse transcription PCR (RT-PCR) and Western blot analysis. Cell proliferation was determined by MTT assay and the invasion and migration abilities of EC109 cells were monitored by Transwell TM assay. The protein levels of proliferating cell nuclear antigen (PCNA), Bax and Bcl-2 were tested by Western blotting. Results The positive expression rate of NEDD9 in esophageal carcinoma tissues was significantly higher compared with that in the paracancerous tissues. After NEDD9 expression was successfully downregulated in EC109 cells by siRNA, the proliferation, invasion and migration rates in transfection group were significantly lower than those in control group; meanwhile, the expression of Bcl-2 was reduced and Bax expression was enhanced. Conclusion The protein expression level of NEDD9 is higher in esophageal carcinoma tissues than that in adjacent normal tissues. Knockdown of NEDD9 expression can restrain the proliferation, invasion and migration of EC109 cells.

(EC+β+) decay of 130Ce

International Nuclear Information System (INIS)

Xu Shuwei; Zhang Tianmei; Xie Yuanxiang; Ma Ruichang; Ge Yuanxiu; Guo Yingxiang; Wang Chunfang; Li Zhankui; Guo Bing; Xing Jianping; Guo Tianrui; Zhu Shaofei; Xu Wang; Du Jinzhou

1996-01-01

The nuclide 130 Ce was produced by a ( 16 O, 4n) reaction on an enriched 118 Sn target. Reaction products were transported to a shielded location by using a helium-jet tape transport system. A 22.9 min activity in chemically separated cerium sample was identified as 130 Ce. The (EC+β + ) decay scheme of 130 Ce was proposed for the first time. This scheme includes 108 γ-lines, 107 γ-lines among them being new. More than 13 1 + low-lying states of 130 La are populated in the decay of 130 Ce. Two new isomers with half-life of 77±10 ns and 17±5 ns were observed by means of delayed γ-γ coincidence measurements. (orig.). With 5 figs., 3 tabs

A new verification film system for routine quality control of radiation fields: Kodak EC-L

International Nuclear Information System (INIS)

Hermann, A.; Bratengeier, K.; Priske, A.; Flentje, M.

2000-01-01

Background: The use of modern irradiation techniques requires better verification films for determining set-up deviations and patient movements during the course of radiation treatment. This is an investigation of the image quality and time requirement of a new verification film system compared to a conventional portal film system. Material and Methods: For conventional verifications we used Agfa Curix HT 1000 films which were compared to the new Kodak EC-L film system. 344 Agfa Curix HT 1000 and 381 Kodak EC-L portal films of different tumor sites (prostate, rectum, head and neck) were visually judged on a light box by 2 experienced physicians. Subjective judgement of image quality, masking of films and time requirement were checked. Results: In this investigation 68% of 175 Kodak EC-L ap/pa-films were judged 'good', only 18% were classified 'moderate' or 'poor' 14%, but only 22% of 173 conventional ap/pa verification films (Agfa Curix HT 1000) were judged to be 'good'. Conclusions: The image quality, detail perception and time required for film inspection of the new Kodak EC-L film system was significantly improved when compared with standard portal films. They could be read more accurately and the detection of set-up deviation was facilitated. (orig.) [de

620 ASSESSMENT OF HEAVY METALS, pH AND EC IN EFFLUENT ...

African Journals Online (AJOL)

Osondu

evaluated metals were Cu, Fe, Ni, Mn, Cr, Zn, Cd, Co, and Ag. The pH, EC, TDS, DO ... heavy metals, but the high heavy metal concentrations in the soil could seriously ... Key words: Heavy metals, AAS, contamination, floriculture and effluents.

Fingerprints of field-induced Berezinskii–Kosterlitz–Thouless transition in quasi-two-dimensional S=1/2 Heisenberg magnets Cu(en)(H2O)2SO4 and Cu(tn)Cl2

International Nuclear Information System (INIS)

Baranová, Lucia; Orendáčová, Alžbeta; Čižmár, Erik; Tarasenko, Róbert; Tkáč, Vladimír; Orendáč, Martin; Feher, Alexander

2016-01-01

Organo-metallic compounds Cu(en)(H 2 O) 2 SO 4 (en=C 2 H 8 N 2 ) and Cu(tn)Cl 2 (tn=C 3 H 10 N 2 ) representing S=1/2 quasi-two-dimensional Heisenberg antiferromagnets with an effective intra-layer exchange coupling J/k B ≈3 K, have been examined by specific heat measurements at temperatures down to nominally 50 mK and magnetic fields up to 14 T. A comparative analysis of magnetic specific heat in zero magnetic field revealed nearly identical contribution of short-range magnetic correlations and significant differences were observed at lowest temperatures. A phase transition to long-range order was observed in Cu(en)(H 2 O) 2 SO 4 at T C =0.9 K while hidden in Cu(tn)Cl 2 . A response of both compounds to the application of magnetic field has rather universal features characteristic for a field-induced Berezinskii–Kosterlitz–Thouless transition theoretically predicted for ideal two-dimensional magnets. - Highlights: • Magnetic specific heat of Cu(en)(H 2 O) 2 SO 4 (1) and Cu(tn)Cl 2 (2) was analysed. • In zero magnetic field, (1) and (2) behave as quasi-two-dimensional magnets. • We observed universal thermodynamic response of (1) and (2) to applied field. • Features of field-induced Berezinskii–Kosterlitz–Thouless transition were detected.

Analysis of Well ER-EC-7 Testing, Western Pahute Mesa - Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-7 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program was documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-7 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-8 testing, Western Pahute Mesa-Oasis Valley FY 2000 testing program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-8 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa-Oasis Valley, Well ER-EC-8 Data Report for development and Hydraulic Testing.

Analysis of Well ER-EC-4 Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-4 during the Western Pahute Mesa-Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-4 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-5 Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-5 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-5 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-6 Testing, Western Pahute Mesa - Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-6 during the Western Pahute Mesa-Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa-Oasis Valley, Well ER-EC-6 Data Report for Development and Hydraulic Testing.

Analysis of Well ER-EC-1 Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-1 during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-1 Data Report for Development and Hydraulic Testing.

Capability and limits of EC policy and instruments for protection of the environment

International Nuclear Information System (INIS)

Jarass, H.D.; Neumann, L.F.; Pastowski, A.; Ruhr, H.J. von der; Schreiber, F.

1994-01-01

The authors who contributed to this compilation of studies start from different points of view in their approaches towards describing the existing (or desirable) balance between centralised and decentralised frameworks and instruments of the EC policy for protection of the environment: A total harmonisation of environmental protection standards would be inconsistent with the principles of competition and, in terms of environmental protection, would rather foster a climate tending to be hostile to innovation. The impetus given by the EC in support of free mobility in the transport sector of the internal market on the other hand ought to be flanked by mandatory ecological standards. Adhering to the economic theory of federalism would mean to decide for a high degree of decentralisation, which in turn does not seem to be altogether appropriate in view of the large scope of impact of environmental damage and the mutual ecological dependence of EC member states. A more centralised regulatory competence has to be accompanied by correspondingly strong, democratic institutions in order to fulfill the principles of constitutional law. The priority given to the principle of subsidiarity in the compromise laid down in the Treaty of Maastricht needs to be given concrete shape [de

Estrutura de comunidades em transições ambientais : lagartos no ecótono Cerrado-Amazônia

OpenAIRE

Dantas, Pedro Tourinho

2014-01-01

Os limites ecológicos desempenham um papel crucial no fluxo de espécies, de genes e 2 nutrientes entre áreas adjacentes. Os limites não apenas separam, mas também conectam 3 estas áreas, agindo como filtros de permeabilidade variável. A estrutura das comunidades 4 varia com a proximidade do ecótono e a riqueza de espécies no ecótono pode ser maior que, 5 menor que, ou intermediária entre as áreas adjacentes. Aqui, eu investigo como o ecótono 6 isola a Amazônia e o Cerrado, atuando como um fil...

Stability of the Gel Electrolyte PAN : EC : PC : LICF3SO3 towards Lithium

DEFF Research Database (Denmark)

Perera, Kumudu; Dissanayake, M.A.K.L.; Skaarup, Steen

2006-01-01

The stability of the gel electrolyte consisting of polyacrylonitrile (PAN), ethylene carbonate (EC), propylene carbonate (PC) and lithium trifluoromethanesulfonate (LiCF3SO3 – LiTF) towards metallic lithium was investigated using the time evolution of impedance plots. Symmetric cells of the form Li...... / PAN : EC : PC: LiTF / Li were assembled and impedance data were collected at room temperature for one week. A clear indication of growth of a resistive layer could be seen. The electrolyte resistance remained constant. The growth of the passivation layer became constant after first two days...

76 FR 30987 - Termination of Action and Further Monitoring in Connection With the EC-Beef Hormones Dispute

Science.gov (United States)

2011-05-27

... Connection With the EC-Beef Hormones Dispute AGENCY: Office of the United States Trade Representative. ACTION... Hormones dispute. In January 2009, the Trade Representative announced a determination to modify the list of...) in the EC-Beef Hormones dispute. The MOU provides for the EU to make phased increases in market...

Molecular characterization of EcCIPK24 gene of finger millet (Eleusine coracana) for investigating its regulatory role in calcium transport.

Science.gov (United States)

Chinchole, Mahadev; Pathak, Rajesh Kumar; Singh, Uma M; Kumar, Anil

2017-08-01

Finger millet grains contain exceptionally high levels of calcium which is much higher compared to other cereals and millets. Since calcium is an important macronutrient in human diet, it is necessary to explore the molecular basis of calcium accumulation in the seeds of finger millet. CIPK is a calcium sensor gene, having role in activating Ca 2+ exchanger protein by interaction with CBL proteins. To know the role of EcCIPK24 gene in seed Ca 2+ accumulation, sequence is retrieved from the transcriptome data of two finger millet genotypes GP1 (low Ca 2+ ) and GP45 (high Ca 2+ ), and the expression was determined through qRT-PCR. The higher expression was found in root, shoot, leaf and developing spike tissue of GP45 compared to GP1; structural analysis showed difference of nine SNPs and one extra beta sheet domain as well as differences in vacuolar localization was predicted; besides, the variation in amino acid composition among both the genotypes was also investigated. Molecular modeling and docking studies revealed that both EcCBL4 and EcCBL10 showed strong binding affinity with EcCIPK24 (GP1) compared to EcCIPK24 (GP45). It indicates a genotypic structural variation, which not only affects the affinity but also calcium transport efficiency after interaction of CIPK-CBL with calcium exchanger ( Ec CAX1b) to pull calcium in the vacuole. Based on the expression and in silico study, it can be suggested that by activating EcCAX1b protein, EcCIPK24 plays an important role in high seed Ca 2+ accumulation.

[Establishment of Reference Value of Hs-cTnT in Sichuan Region and Its Diagnostic Value in Patients with Chest Pain].

Science.gov (United States)

Guo, Ying; Du, Xiang-Yang; Huang, Hua-Lan; Wang, Wei-Qing; Nie, Xin; Li, Gui-Xing

2017-11-01

To establish the reference value of high sensitive cardiac troponin T (hs-cTnT) and the efficiency of reference value in the diagnosis of chest pain. Volunteers from eight independent communities in Chengdu,Sichuan were selected with detailed records of physical examination,electrocardiogram,ultrasound examination. The level of hs-cTnT for healthy volunteers was tested to determine ninety-ninth percentile references according to sex and ages. 2 249 patients with chest pain in the emergency department of Western China Hospital from July 2009 to July 2014 were enrolled to measure the efficiency of reference value for diagnosing acute myocardial infarction (AMI). There were 1 305 volunteers included finally. Among them,the mean hs-cTnT level of male was 4.3 (3.2-5.9) ng/L,which was significantly higher than that of female 3.0 (3.0-3.1) ng/L ( P value was less than 0.01. The 99th percentile values of male were 10.8 ng/L,15.4 ng/L and 19.7 ng/L for values of female were 4.6 ng/L,8.9 ng/L,18.8 ng/L,respectively. There was no difference in sensitivity and specificity between the value we figured out and manufactures provided (14.0 ng/L) for thosevalue did not show diversity ( P >0.05) but the specificity and positive predictive value showed significant difference (male: 0.67 vs. 0.56 and 0.83 vs. 0.79, P value of patients<60 yr. should be 14.0 ng/L,while 20.0 ng/L for those patients≥60 yr.

Effect of Graphene-EC on Ag NW-Based Transparent Film Heaters: Optimizing the Stability and Heat Dispersion of Films.

Science.gov (United States)

Cao, Minghui; Wang, Minqiang; Li, Le; Qiu, Hengwei; Yang, Zhi

2018-01-10

To optimize the performance of silver nanowire (Ag NW) film heaters and explore the effect of graphene on a film, we introduced poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) and graphene modified with ethyl cellulose (graphene-EC) into the film. The high-quality and well-dispersed graphene-EC was synthesized from graphene obtained by electrochemical exfoliation as a precursor. The transparent film heaters were fabricated via spin-coating. With the assistance of graphene-EC, the stability of film heaters was greatly improved, and the conductivity was optimized by adjusting the Ag NW concentration. The film heaters exhibited a fast and accurate response to voltage, accompanied by excellent environmental endurance, and there was no significant performance degradation after being operated for a long period of time. These results indicate that graphene-EC plays a crucial role in optimizing film stability and heat dispersion in the film. The Ag NW/PEDOT:PSS-doped graphene-EC film heaters show a great potential in low-cost indium-tin-oxide-free flexible transparent electrodes, heating systems, and transparent film heaters.

Effect of condensed tannins in hulls of faba beans (Vivia faba L.) on the activities of trypsin (EC 2.4.21.4) and chymotrypsin (EC 2.4.21.1) in digesta collected from the small intestine of pigs

NARCIS (Netherlands)

Jansman, A.J.M.; Enting, H.; Verstegen, M.W.A.; Huisman, J.

1994-01-01

The effects of condensed tannins in hulls of faba beans (Vicia faba L.) on the activities of trypsin (EC 3.4.21.4) and chymotrypsin (EC 3.4.21.1) in digesta obtained from the small intestine of pigs were studied. Using four castrated male pigs (mean body weight 83 kg) fitted with both a simple

Elaboration and quality control of the inoculum of the experimental vaccine Brucella S19-tn7-GFP for use in white animals and associated serological test for the detection of anti-GFP antibodies

International Nuclear Information System (INIS)

Salas Alfaro, Dariana

2014-01-01

The preparation of the inoculum of the experimental vaccine Brucella S19-Tn7-GFP is optimized for application in white animals. An associated serological test has allowed differentiating infected animals from those vaccinated with the experimental strain. The same bacteriological and biological properties of the B. abortus S19-Tn7-GFP strain have maintained in the parental vaccine strain S19 and is stable over time. A protocol for the inoculums of strain S19-Tn7-GFP is established for its preparation and use in white animals and quality control. The inoculum stability is evaluated through the simulation of conditions that can be presented in the transportation and application process in the field. An enzyme immunoassay ELISA is optimized for the detection of anti-GFP antibodies in cattle [es

A look at the ocean in the EC-Earth climate model

Energy Technology Data Exchange (ETDEWEB)

Sterl, Andreas; Bintanja, Richard; Severijns, Camiel [Royal Netherlands Meteorological Institute (KNMI), P.O. Box 201, De Bilt (Netherlands); Brodeau, Laurent [Stockholm University, Department of Meteorology, Stockholm (Sweden); Gleeson, Emily; Semmler, Tido [Met Eireann, Dublin (Ireland); Koenigk, Torben; Wyser, Klaus [Swedish Meteorological and Hydrological Institute (SMHI), Norrkoeping (Sweden); Schmith, Torben; Yang, Shuting [Danish Meteorological Institute (DMI), Copenhagen (Denmark)

2012-12-15

EC-Earth is a newly developed global climate system model. Its core components are the Integrated Forecast System (IFS) of the European Centre for Medium Range Weather Forecasts (ECMWF) as the atmosphere component and the Nucleus for European Modelling of the Ocean (NEMO) developed by Institute Pierre Simon Laplace (IPSL) as the ocean component. Both components are used with a horizontal resolution of roughly one degree. In this paper we describe the performance of NEMO in the coupled system by comparing model output with ocean observations. We concentrate on the surface ocean and mass transports. It appears that in general the model has a cold and fresh bias, but a much too warm Southern Ocean. While sea ice concentration and extent have realistic values, the ice tends to be too thick along the Siberian coast. Transports through important straits have realistic values, but generally are at the lower end of the range of observational estimates. Exceptions are very narrow straits (Gibraltar, Bering) which are too wide due to the limited resolution. Consequently the modelled transports through them are too high. The strength of the Atlantic meridional overturning circulation is also at the lower end of observational estimates. The interannual variability of key variables and correlations between them are realistic in size and pattern. This is especially true for the variability of surface temperature in the tropical Pacific (El Nino). Overall the ocean component of EC-Earth performs well and helps making EC-Earth a reliable climate model. (orig.)

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer

Science.gov (United States)

Munkley, Jennifer; Oltean, Sebastian; Vodák, Daniel; Wilson, Brian T.; Livermore, Karen E.; Zhou, Yan; Star, Eleanor; Floros, Vasileios I.; Johannessen, Bjarne; Knight, Bridget; McCullagh, Paul; McGrath, John; Crundwell, Malcolm; Skotheim, Rolf I.; Robson, Craig N.; Leung, Hing Y.; Harries, Lorna W.; Rajan, Prabhakar; Mills, Ian G.; Elliott, David J.

2015-01-01

Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood. The androgen receptor drives prostate cancer (PCa) development and progression to lethal metastatic castration-resistant disease. Here we used RNA-Seq coupled with bioinformatic analyses of androgen-receptor (AR) binding sites and clinical PCa expression array data to identify ST6GalNAc1 as a direct and rapidly activated target gene of the AR in PCa cells. ST6GalNAc1 encodes a sialytransferase that catalyses formation of the cancer-associated sialyl-Tn antigen (sTn), which we find is also induced by androgen exposure. Androgens induce expression of a novel splice variant of the ST6GalNAc1 protein in PCa cells. This splice variant encodes a shorter protein isoform that is still fully functional as a sialyltransferase and able to induce expression of the sTn-antigen. Surprisingly, given its high expression in tumours, stable expression of ST6GalNAc1 in PCa cells reduced formation of stable tumours in mice, reduced cell adhesion and induced a switch towards a more mesenchymal-like cell phenotype in vitro. ST6GalNAc1 has a dynamic expression pattern in clinical datasets, being significantly up-regulated in primary prostate carcinoma but relatively down-regulated in established metastatic tissue. ST6GalNAc1 is frequently upregulated concurrently with another important glycosylation enzyme GCNT1 previously associated with prostate cancer progression and implicated in Sialyl Lewis X antigen synthesis. Together our data establishes an androgen-dependent mechanism for sTn antigen expression in PCa, and are consistent with a general role for the androgen receptor in driving important coordinate changes to the glycoproteome during PCa progression. PMID:26452038

A miniature integrated multimodal sensor for measuring pH, EC and temperature for precision agriculture.

Science.gov (United States)

Futagawa, Masato; Iwasaki, Taichi; Murata, Hiroaki; Ishida, Makoto; Sawada, Kazuaki

2012-01-01

Making several simultaneous measurements with different kinds of sensors at the same location in a solution is difficult because of crosstalk between the sensors. In addition, because the conditions at different locations in plant beds differ, in situ measurements in agriculture need to be done in small localized areas. We have fabricated a multimodal sensor on a small Si chip in which a pH sensor was integrated with electrical conductivity (EC) and temperature sensors. An ISFET with a Si(3)N(4) membrane was used for the pH sensor. For the EC sensor, the electrical conductivity between platinum electrodes was measured, and the temperature sensor was a p-n junction diode. These are some of the most important measurements required for controlling the conditions in plant beds. The multimodal sensor can be inserted into a plant bed for in situ monitoring. To confirm the absence of crosstalk between the sensors, we made simultaneous measurements of pH, EC, and temperature of a pH buffer solution in a plant bed. When the solution was diluted with hot or cold water, the real time measurements showed changes to the EC and temperature, but no change in pH. We also demonstrated that our sensor was capable of simultaneous in situ measurements in rock wool without being affected by crosstalk.

RNA of Enterococcus faecalis Strain EC-12 Is a Major Component Inducing Interleukin-12 Production from Human Monocytic Cells.

Directory of Open Access Journals (Sweden)

Ryoichiro Nishibayashi

Full Text Available Interleukin-12 (IL-12 is an important cytokine for the immunomodulatory effects of lactic acid bacteria (LAB. Using murine immune cells, we previously reported that the RNA of Enterococcus faecalis EC-12, a LAB strain exerting probiotic-like beneficial effects, is the major IL-12-inducing immunogenic component. However, it was recently revealed that bacterial RNA can be a ligand for Toll-like receptor (TLR 13, which is only expressed in mice. Because TLR13 is not expressed in humans, the immuno-stimulatory and -modulatory effects of LAB RNA in human cells should be augmented excluding TLR13 contribution. In experiment 1 of this study, the role of LAB RNA in IL-12 induction in human immune cells was studied using three LAB strains, E.faecalis EC-12, Lactobacillus gasseri JCM5344, and Bifidobacterium breve JCM1192. RNase A treatment of heat-killed LAB significantly decreased the IL-12 production of human peripheral blood mononuclear cells on stimulation, while RNase III treatment revealed virtually no effects. Further, IL-12 production against heat-killed E. faecalis EC-12 was abolished by depleting monocytes. These results demonstrated that single stranded RNA (ssRNA of LAB is a strong inducer of IL-12 production from human monocytes. In experiment 2, major receptor for ssRNA of E. faecalis EC-12 was identified using THP-1 cells, a human monocytic cell line. The type of RNA molecules of E. faecalis EC-12 responsible for IL-12 induction was also identified. IL-12 production induced by the total RNA of E. faecalis EC-12 was significantly reduced by the treatment of siRNA for TLR8 but not for TLR7. Furthermore, both 23S and 16S rRNA, but not mRNA, of E. faecalis EC-12 markedly induced IL-12 production from THP-1 cells. These results suggested that the recognition of ssRNA of E. faecalis EC-12 was mediated by TLR8 and that rRNA was the RNA molecule that exhibited IL-12-inducing ability in human cells.

Research and development programme of the EC in the field of raw materials 1982 to 1985

International Nuclear Information System (INIS)

Anon.

1982-01-01

Brussels: The EC Cabinet Council was presented a research and development programme in the field of raw materials for the years 1982 to 1985 which covers programmes already running and new actions as an overlapping raw material research programme of the EC. The new programme is divided up into 7 subprogrammes: I) metals and minerals (formerly: primary raw materials, II) uranium, III) ceramics, IV) wood as a renewable raw material, V) recycling of wastes (house and industry, VI) regaining of non-iron metals, VII) substitution. For the continuing of running actions and for beginning new projects in the 4 years plan, a total of 17 million ECU are to be allocated in the budget of the EC which will be used in cost sharing contracts or for coordinative projects. (orig./UA) [de

Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus Detox adjuvant.

Science.gov (United States)

MacLean, G D; Reddish, M; Koganty, R R; Wong, T; Gandhi, S; Smolenski, M; Samuel, J; Nabholtz, J M; Longenecker, B M

1993-01-01

We have synthesized various formulations that have potential for active specific immunotherapy (ASI) of human cancers. Sialyl-Tn (STn) is a potentially important target structure for ASI because its expression on mucins is a strong, independent predictor of poor prognosis, suggesting that it may have functional significance in the metastatic process. In this first pilot study of synthetic sialyl-Tn hapten conjugated to keyhole limpet hemocyanin (STn-KLH), with Detox adjuvant, toxicity and humoral immunogenicity were assessed in 12 patients with metastatic breast cancer. Toxicity was minimal, restricted to local cutaneous reactions (apart from transient nausea and vomiting following single low-dose cyclophosphamide treatment). Using STn-conjugated human serum albumin in a solid-phase enzyme-linked immunosorbent assay, it was shown that all patients developed IgM and IgG specific for the synthetic STn hapten. Following immunization, most patients were shown to develop increased titres of complement-mediated cytotoxic antibodies, partially inhibited by synthetic STn hapten, but not by the related TF hapten. We also detected IgM and IgG antibodies reactive with natural STn determinants expressed on ovine submaxillary mucin, the STn specificity of this reactivity being confirmed by hapten inhibition. Evaluation of clinical efficacy in a small pilot study is difficult. Five patients are alive 12 or more months after entry, and another 4 patients are alive 6 or more months after entry into the study. All 3 patients with known widespread bulky disease progressed despite ASI, 2 having died from widespread cancer. Two patients had partial responses, each lasting 6 months. While several patients had disease stability for 3-10 months, 1 patient with pulmonary metastases remains stable 15 months after entry into the program.

The planned EC Directive on 'Integrated Pollution Prevention and Control' (IPC)

International Nuclear Information System (INIS)

Sellner, D.; Schnutenhaus, J.

1993-01-01

This EC Directive is intended to incorporate integrated pollution control as a mandatory obligation in the legal provisions governing industrial installations licensing within the EC. The article in hand presents an assessment of the Directive and discusses some possible impacts on the German national law in the field of pollution control, which hitherto has been defined on the basis of a preferably medium-oriented approach. A serious point of deviation from the German approach is seen in the fact that the draft's provisions relating to the licensing of industrial installations defines certain pre-conditions allowing a plant in a low-polluted area to be licensed, although the pollution control systems of the plant do not them come up to the state-of-the-art in pollution abatement technology. This is seen as a fact jeopardizing the principle of precantionary measures which has been firmly established in German pollution control law. (orig./HP) [de

Linear and exponential TAIL-PCR: a method for efficient and quick amplification of flanking sequences adjacent to Tn5 transposon insertion sites.

Science.gov (United States)

Jia, Xianbo; Lin, Xinjian; Chen, Jichen

2017-11-02

Current genome walking methods are very time consuming, and many produce non-specific amplification products. To amplify the flanking sequences that are adjacent to Tn5 transposon insertion sites in Serratia marcescens FZSF02, we developed a genome walking method based on TAIL-PCR. This PCR method added a 20-cycle linear amplification step before the exponential amplification step to increase the concentration of the target sequences. Products of the linear amplification and the exponential amplification were diluted 100-fold to decrease the concentration of the templates that cause non-specific amplification. Fast DNA polymerase with a high extension speed was used in this method, and an amplification program was used to rapidly amplify long specific sequences. With this linear and exponential TAIL-PCR (LETAIL-PCR), we successfully obtained products larger than 2 kb from Tn5 transposon insertion mutant strains within 3 h. This method can be widely used in genome walking studies to amplify unknown sequences that are adjacent to known sequences.

Inactivation of the Ecs ABC Transporter of Staphylococcus aureus Attenuates Virulence by Altering Composition and Function of Bacterial Wall

NARCIS (Netherlands)

Jonsson, Ing-Marie; Juuti, Jarmo T.; Francois, Patrice; AlMajidi, Rana; Pietiainen, Milla; Girard, Myriam; Lindholm, Catharina; Saller, Manfred J.; Driessen, Arnold J. M.; Kuusela, Pentti; Bokarewa, Maria; Schrenzel, Jacques; Kontinen, Vesa P.

2010-01-01

Background: Ecs is an ATP-binding cassette (ABC) transporter present in aerobic and facultative anaerobic Gram-positive Firmicutes. Inactivation of Bacillus subtilis Ecs causes pleiotropic changes in the bacterial phenotype including inhibition of intramembrane proteolysis. The molecule(s)

Completion Report for Well ER-EC-1

International Nuclear Information System (INIS)

Townsend, M.J.

2000-01-01

Well ER-EC-1 was drilled for the U.S. Department of Energy, Nevada Operations Office in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. This well was drilled in the spring of 1999 as part of the U.S. Department of Energy's hydrogeologic investigation well program in the Western Pahute Mesa - Oasis Valley region just west of the Test Site. A 44.5-centimeter surface hole was drilled and cased off to the depth 675.1 meters below the surface. The hole diameter was then decreased to 31.1 centimeters for drilling to a total depth of 1,524.0 meters. A preliminary composite, static, water level was measured at the depth of approximately 566.3 meters prior to installation of the completion string. One completion string with three isolated, slotted intervals was installed in the well. Detailed lithologic descriptions with preliminary stratigraphic assignments are included in the report. These are based on composite drill cuttings collected every 3 meters and 31 sidewall samples taken at various depths below 680 meters, supplemented by geophysical log data. Detailed chemical and mineralogical studies of rock samples are in progress. The well penetrated Tertiary-age lava and tuff of the Timber Mountain Group, the Paintbrush Group, the Calico Hills Formation, the Crater Flat Group, and the Volcanics of Quartz Mountain. The preliminary geologic interpretation of data from Well ER-EC-1 indicates the presence of a structural trough or bench filled with a thick section of post-Rainier Mesa lava. These data also suggest that this site is located on a buried structural ridge that may separate the Silent Canyon and Timber Mountain caldera complexes

Ferro-based derivatizing agents for LC/MS an LC/EC/MS

NARCIS (Netherlands)

Seiwert, Bettina

2007-01-01

Within this thesis, the development and application of ferrocene-based derivatizing agents for LC/MS and LC/EC/MS is presented. The advantages of derivatization by ferrocenes are the similtaneous introduction of a mass tag and an electroactive group, which make them ideally suited for LC/MS and

Volcanic ash leaching as a means of tracing the environmental impact of the 2011 Grímsvötn eruption, Iceland.

Science.gov (United States)

Cabré, J; Aulinas, M; Rejas, M; Fernandez-Turiel, J L

2016-07-01

The Grímsvötn volcanic eruption, from 21 to 28 May, 2011, was the largest eruption of the Grímsvötn Volcanic System since 1873, with a Volcanic Explosivity Index (VEI) of magnitude 4. The main geochemical features of the potential environmental impact of the volcanic ash-water interaction were determined using two different leaching methods as proxies (batch and vertical flow-through column experiments). Ash consists of glass with minor amounts of plagioclase, clinopyroxene, diopside, olivine and iron sulphide; this latter mineral phase is very rare in juvenile ash. Ash grain morphology and size reflect the intense interaction of magma and water during eruption. Batch and column leaching tests in deionised water indicate that Na, K, Ca, Mg, Si, Cl, S and F had the highest potential geochemical fluxes to the environment. Release of various elements from volcanic ash took place immediately through dissolution of soluble salts from the ash surface. Element solubilities of Grímsvötn ash regarding bulk ash composition were <1 %. Combining the element solubilities and the total estimated mass of tephra (7.29 × 10(14) g), the total inputs of environmentally important elements were estimated to be 8.91 × 10(9) g Ca, 7.02 × 10(9) g S, 1.10 × 10(9) g Cl, 9.91 × 10(8) g Mg, 9.91 × 10(8) g Fe and 1.45 × 10(8) g P The potential environmental problems were mainly associated with the release of F (5.19 × 10(9) g).

A Miniature Integrated Multimodal Sensor for Measuring pH, EC and Temperature for Precision Agriculture

Directory of Open Access Journals (Sweden)

Hiroaki Murata

2012-06-01

Full Text Available Making several simultaneous measurements with different kinds of sensors at the same location in a solution is difficult because of crosstalk between the sensors. In addition, because the conditions at different locations in plant beds differ, in situ measurements in agriculture need to be done in small localized areas. We have fabricated a multimodal sensor on a small Si chip in which a pH sensor was integrated with electrical conductivity (EC and temperature sensors. An ISFET with a Si₃N₄ membrane was used for the pH sensor. For the EC sensor, the electrical conductivity between platinum electrodes was measured, and the temperature sensor was a p-n junction diode. These are some of the most important measurements required for controlling the conditions in plant beds. The multimodal sensor can be inserted into a plant bed for in situ monitoring. To confirm the absence of crosstalk between the sensors, we made simultaneous measurements of pH, EC, and temperature of a pH buffer solution in a plant bed. When the solution was diluted with hot or cold water, the real time measurements showed changes to the EC and temperature, but no change in pH. We also demonstrated that our sensor was capable of simultaneous in situ measurements in rock wool without being affected by crosstalk.

Effect of the polymer concentration on the ON/OFF states of a TN-LCD: polyvinyl alcohol vs. soy lecithin

Science.gov (United States)

de Coss Martinez, Romeo; Gonzalez Murguia, Jose Luis

2011-03-01

In this work we study the response of a Twisted Nematic Liquid Crystal Display (TN-LCD) by varying both the concentration and the polymer used for the microgroove. We compare the performance of two polymers: polyvinyl alcohol and soy lecithin. In particular, the light transmission for the ON/OFF states is evaluated. The polyvinyl alcohol is a polymer widely used in LCDs while lecithin soy is a natural polymer.

GPM GROUND VALIDATION ENVIRONMENT CANADA (EC) MICRO RAIN RADAR (MRR) GCPEX V1

Data.gov (United States)

National Aeronautics and Space Administration — Environment Canada (EC) collected data from the Micro Rain Radar (MRR) during the GPM Cold-season Precipitation Experiment (GCPEx) in Ontario, Canada during the...

LiPF{sub 6}. Synthesis and stability in EC/DMC and PC/DMC mixtures; LiPF{sub 6}. Synthese et stabilite dans les melanges EC/DMC et PC/DMC

Energy Technology Data Exchange (ETDEWEB)

Naejus, R.; Coudert, R.; Lemordant, D. [Laboratoire P.I.M.I.R. EA, Sciences et Techniques, 37 - Tours (France); Willmann, P. [CNES, 31 - Toulouse (France)

1996-12-31

Lithium hexa-fluoro-phosphate LiPF{sub 6} is recommended for the replacement of the toxic LiAsF{sub 6} and the explosive perchlorates (like LiClO{sub 4}) in rechargeable lithium electrochemical generators. The aim of this work is to develop a new method of synthesis of this salt and to check its stability with respect to carbonated solvents: ethylene carbonate (EC), propylene carbonate (PC) and dimethyl-carbonate (DMC) in already optimized EC/DMC and PC/DMC binary mixtures. Two methods using HPF{sub 6} are proposed: the first one uses the direct neutralization of this commercial acid by LiOH in aqueous, alcoholic or acetonitrile environment, while in the second one LiPF{sub 6} is obtained from pyridinium hexa-fluoro-phosphate synthesized from HPF{sub 6} using a new and simple protocol. (J.S.) 24 refs.

LiPF{sub 6}. Synthesis and stability in EC/DMC and PC/DMC mixtures; LiPF{sub 6}. Synthese et stabilite dans les melanges EC/DMC et PC/DMC

Energy Technology Data Exchange (ETDEWEB)

Naejus, R; Coudert, R; Lemordant, D [Laboratoire P.I.M.I.R. EA, Sciences et Techniques, 37 - Tours (France); Willmann, P [CNES, 31 - Toulouse (France)

1997-12-31

Lithium hexa-fluoro-phosphate LiPF{sub 6} is recommended for the replacement of the toxic LiAsF{sub 6} and the explosive perchlorates (like LiClO{sub 4}) in rechargeable lithium electrochemical generators. The aim of this work is to develop a new method of synthesis of this salt and to check its stability with respect to carbonated solvents: ethylene carbonate (EC), propylene carbonate (PC) and dimethyl-carbonate (DMC) in already optimized EC/DMC and PC/DMC binary mixtures. Two methods using HPF{sub 6} are proposed: the first one uses the direct neutralization of this commercial acid by LiOH in aqueous, alcoholic or acetonitrile environment, while in the second one LiPF{sub 6} is obtained from pyridinium hexa-fluoro-phosphate synthesized from HPF{sub 6} using a new and simple protocol. (J.S.) 24 refs.

Activities of the Sofia EC Energy Center in the framework of the THERMIE programme

International Nuclear Information System (INIS)

Latinski, K.

1993-01-01

The European Community Energy Center in Sofia is responsible for the EC implementation of the THERMIE programme. The programme's activities are promotion and dissemination of existing European technologies leading to better energy management and covering the fields of rational use of hydrocarbons, solid fuels and renewable energy sources. Application of these technologies would lead to substantial energy savings resulting in significant financial and environmental benefits. During its one-year operation the EC Energy Centre has organized and performed specific action as energy audits (food and beverage industrial units and buildings), demonstration projects (local heating control in buildings, diesel engine regulation of buses), training courses and seminars (in energy management and in space heating measuring and regulation), workshops (energy conservation in buildings, the bricks and clays sector and the food and beverage sector) and studies (wind energy potential, 'clean' coal technologies potential). Some of these actions have had very encouraging results showing potential energy savings of the order of 10-20% just by application of simple measures and with small additional investment. The activities of the EC Energy Centre in the coming year aimed at electricity savings along the entire line of electricity generation, transmission and consumption are outlined. (author)

In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells

DEFF Research Database (Denmark)

Sakai, Akito; Takikawa, Shingo; Thimme, Robert

2007-01-01

Both viral and host factors are thought to influence the pathogenesis of hepatitis C virus (HCV) infection. We studied strain HC-TN (genotype 1a), which caused fulminant hepatic failure in a patient and, subsequently, severe hepatitis in a chimpanzee (CH1422), to analyze the relationship between...... persistently infected. CH1579 and CH1581, despite their differing outcomes, both developed significant intrahepatic cellular immune responses, but not antibodies to the envelope glycoproteins or neutralizing antibodies, during the acute infection. We analyzed the polyprotein sequences of virus recovered...

Analysis of Well ER-EC-2a Testing, Western Pahute Mesa-Oasis Valley FY 2000 Testing Program

Energy Technology Data Exchange (ETDEWEB)

None

2002-09-30

This report documents the analysis of the data collected for Well ER-EC-2a during the Western Pahute Mesa - Oasis Valley (WPM-OV) well development and testing program that was conducted during fiscal year (FY) 2000. The data collection for that program is documented in Appendix A, Western Pahute Mesa - Oasis Valley, Well ER-EC-2a Data Report for Development and Hydraulic Testing.

Fossil and non-fossil sources of organic carbon (OC and elemental carbon (EC in Göteborg, Sweden

Directory of Open Access Journals (Sweden)

S. Szidat

2009-03-01

Full Text Available Particulate matter was collected at an urban site in Göteborg (Sweden in February/March 2005 and in June/July 2006. Additional samples were collected at a rural site for the winter period. Total carbon (TC concentrations were 2.1–3.6 μg m⁻³, 1.8–1.9 μg m⁻³, and 2.2–3.0 μg m⁻³ for urban/winter, rural/winter, and urban/summer conditions, respectively. Elemental carbon (EC, organic carbon (OC, water-insoluble OC (WINSOC, and water-soluble OC (WSOC were analyzed for ¹⁴C in order to distinguish fossil from non-fossil emissions. As wood burning is the single major source of non-fossil EC, its contribution can be quantified directly. For non-fossil OC, the wood-burning fraction was determined independently by levoglucosan and ¹⁴C analysis and combined using Latin-hypercube sampling (LHS. For the winter period, the relative contribution of EC from wood burning to the total EC was >3 times higher at the rural site compared to the urban site, whereas the absolute concentrations of EC from wood burning were elevated only moderately at the rural compared to the urban site. Thus, the urban site is substantially more influenced by fossil EC emissions. For summer, biogenic emissions dominated OC concentrations most likely due to secondary organic aerosol (SOA formation. During both seasons, a more pronounced fossil signal was observed for Göteborg than has previously been reported for Zurich, Switzerland. Analysis of air mass origin using back trajectories suggests that the fossil impact was larger when local sources dominated, whereas long-range transport caused an enhanced non-fossil signal. In comparison to other European locations, concentrations of levoglucosan and other monosaccharide anhydrides were low for the urban and the rural site in the area of Göteborg during winter.

Development of novel antibacterial active, HaCaT biocompatible and biodegradable CA-g-P(3HB-EC biocomposites with caffeic acid as a functional entity

Directory of Open Access Journals (Sweden)

H. M. N. Iqbal

2015-09-01

Full Text Available We have developed novel composites by grafting caffeic acid (CA onto the P(3HB-EC based material and laccase from Trametes versicolor was used for grafting purposes. The resulting composites were designated as CA-g-P(3HB-EC i.e., P(3HB-EC (control, 5CA-g-P(3HB-EC, 10CA-g-P(3HB-EC, 15CA-g-P(3HB-EC and 20CA-g-P(3HB-EC. FT-IR (Fourier-transform infrared spectroscopy was used to examine the functional and elemental groups of the control and laccase-assisted graft composites. Evidently, 15CA-g-P(3HB-EC composite exhibited resilient antibacterial activity against Gram-positive and Gram-negative bacterial strains. Moreover, a significant level of biocompatibility and biodegradability of the CA-g-P(3HB-EC composites was also achieved with the human keratinocytes-like HaCaT cells and soil burial evaluation, respectively. In conclusion, the newly developed novel composites with multi characteristics could well represent the new wave of biomaterials for medical applications, and more specifically have promising future in the infection free would dressings, burn and/or skin regeneration field due to their sophisticated characteristics.

THEODORE, a two-step heating system for the EC/OC determination of radiocarbon (14C) in the environment

International Nuclear Information System (INIS)

Szidat, S.; Jenk, T.M.; Gaeggeler, H.W.; Synal, H.-A.; Hajdas, I.; Bonani, G.; Saurer, M.

2004-01-01

Measurements of 14 C in the organic carbon (OC) and elemental carbon (EC) fractions, respectively, of fine aerosol particles bear the potential to apportion anthropogenic and biogenic emission sources. For this purpose, the system THEODORE (two-step heating system for the EC/OC determination of radiocarbon in the environment) was developed. In this device, OC and EC are transformed into carbon dioxide in a stream of oxygen at 340 and 650 deg. C, respectively, and reduced to filamentous carbon. This is the target material for subsequent accelerator mass spectrometry (AMS) 14 C measurements, which were performed on sub-milligram carbon samples at the PSI/ETH compact 500 kV AMS system. Quality assurance measurements of SRM 1649a, Urban Dust, yielded a fraction of modern f M in total carbon (TC) of 0.522 ± 0.018 (n=5, 95% confidence level) in agreement with reported values. The results for OC and EC are 0.70 ± 0.05 (n=3) and 0.066 ± 0.020 (n=4), respectively

Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C.

Science.gov (United States)

Hitrik, Anna; Popliker, Malka; Gancz, Dana; Mukamel, Zohar; Lifshitz, Aviezer; Schwartzman, Omer; Tanay, Amos; Gilboa, Lilach

2016-11-01

The development of niches for tissue-specific stem cells is an important aspect of stem cell biology. Determination of niche size and niche numbers during organogenesis involves precise control of gene expression. How this is achieved in the context of a complex chromatin landscape is largely unknown. Here we show that the nuclear protein Combgap (Cg) supports correct ovarian niche formation in Drosophila by controlling ecdysone-Receptor (EcR)- mediated transcription and long-range chromatin contacts in the broad locus (BR-C). Both cg and BR-C promote ovarian growth and the development of niches for germ line stem cells. BR-C levels were lower when Combgap was either reduced or over-expressed, indicating an intricate regulation of the BR-C locus by Combgap. Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels. Proximity ligation assay indicated that the two proteins could reside in the same complex. Finally, chromatin conformation analysis revealed that EcR-bound regions within BR-C, which span ~30 KBs, contacted each other. Significantly, these contacts were stabilized in an ecdysone- and Combgap-dependent manner. Together, these results highlight Combgap as a novel regulator of chromatin structure that promotes transcription of ecdysone target genes and ovarian niche formation.

Energy policy and the scope of action of the EC; Die energiepolitischen Handlungsmoeglichkeiten der EG

Energy Technology Data Exchange (ETDEWEB)

Brand, E. [Universitaet Lueneburg, Lueneburg (Germany); Witthohn, A. [IHK Hannover (Germany)

2002-04-01

This contribution examines the legal basis of authorization and the scope of action of the European legislator with respect to legislation on the energy policy of the EC. The analysis starts with summarising the evolution of the primary law, looking inter alia at the constitutent treaties of the ECSC, EURATOM, and the EEC, and discusses further developments and treaties, as there is no specific, uniform basis of legislative power of the EC in the energy sector of EC. Subsequently, the basis for and secondary law making is discussed, the concluding part of the article giving an outlook on the future. (orig./CB) [German] Zentrale Frage des folgenden Beitrags ist, woraus der europaeische Gesetzgeber seine Kompetenz im Energiebereich ableitet und wie weit seine Regelungen in dem Bereich gehen duerfen. Um diese Fragen zu beantworten, wird zunaechst die Entwicklung des europaeischen Primaerrechts bzw. der Gruendungsvertraege im Energiebereich beleuchtet und werden die einschlaegigen Ermaechtigungsgrundlagen dargestellt. Im Anschluss daran stehen dann die wichtigsten sekundaerrechtlichen Regelungen im Mittelpunkt. Abschliessend wird ein Ausblick auf die weitere Entwicklung gegeben. (orig./CB)

Risk assesment in the context of EC directives on genetically modified organisms

Energy Technology Data Exchange (ETDEWEB)

Meer, P.J. van der [Ministry for the Environment (Netherlands)

1992-07-01

The introduction of these new molecular technologies initiated an international discussion on the safety in biotechnology. In 1974 one of the pioneers of this new technology, Paul Berg, expressed his view on the potential risks of recombinant DNA applications in the famous 'Berg letter', leading to a self-imposed moratorium on certain experiments. Following the Berg letter and the Asilomar convention, much international attention has been given to the question of safety in biotechnology. This attention resulted in hundreds of documents, research programmes, guidelines and regulations. This resulted, among others, in two EC Directives on genetically modified organisms: the EC Directive 90/219/EEC on the contained use of genetically modified micro-organisms, and Directive 90/220/EEC on the release of genetically modified organisms. These directives lay down a system for harmonization of risk assessment and risk management with regard to the safety for human health and the environment.

Risk assesment in the context of EC directives on genetically modified organisms

International Nuclear Information System (INIS)

Meer, P.J. van der

1992-01-01

The introduction of these new molecular technologies initiated an international discussion on the safety in biotechnology. In 1974 one of the pioneers of this new technology, Paul Berg, expressed his view on the potential risks of recombinant DNA applications in the famous 'Berg letter', leading to a self-imposed moratorium on certain experiments. Following the Berg letter and the Asilomar convention, much international attention has been given to the question of safety in biotechnology. This attention resulted in hundreds of documents, research programmes, guidelines and regulations. This resulted, among others, in two EC Directives on genetically modified organisms: the EC Directive 90/219/EEC on the contained use of genetically modified micro-organisms, and Directive 90/220/EEC on the release of genetically modified organisms. These directives lay down a system for harmonization of risk assessment and risk management with regard to the safety for human health and the environment

Agricultural price and income policy in the EC : alternative policies and their implications

NARCIS (Netherlands)

Meester, G.

1980-01-01

Alternative forms of income policy without direct supply control. Alternative forms of income policy with direct supply control: quota arrangements. The influence of EC policy on the world market prices of agricultural produce

MicroRNA-281 regulates the expression of ecdysone receptor (EcR) isoform B in the silkworm, Bombyx mori

Science.gov (United States)

Hundreds of Bombyx mori miRNAs had been identified in recent years, but their function in vivo remains poorly understood. The silkworm EcR gene (BmEcR) has three transcriptional isoforms, A, B1 and B2. Isoform sequences are different in the 3’UTR region of the gene, which is the case only in insects...

SIPSMetGen: It's Not Just For Aircraft Data and ECS Anymore.

Science.gov (United States)

Schwab, M.

2015-12-01

The SIPSMetGen utility, developed for the NASA EOSDIS project, under the EED contract, simplified the creation of file level metadata for the ECS System. The utility has been enhanced for ease of use, efficiency, speed and increased flexibility. The SIPSMetGen utility was originally created as a means of generating file level spatial metadata for Operation IceBridge. The first version created only ODL metadata, specific for ingest into ECS. The core strength of the utility was, and continues to be, its ability to take complex shapes and patterns of data collection point clouds from aircraft flights and simplify them to a relatively simple concave hull geo-polygon. It has been found to be a useful and easy to use tool for creating file level metadata for many other missions, both aircraft and satellite. While the original version was useful it had its limitations. In 2014 Raytheon was tasked to make enhancements to SIPSMetGen, this resulted a new version of SIPSMetGen which can create ISO Compliant XML metadata; provides optimization and streamlining of the algorithm for creating the spatial metadata; a quicker runtime with more consistent results; a utility that can be configured to run multi-threaded on systems with multiple processors. The utility comes with a java based graphical user interface to aid in configuration and running of the utility. The enhanced SIPSMetGen allows more diverse data sets to be archived with file level metadata. The advantage of archiving data with file level metadata is that it makes it easier for data users, and scientists to find relevant data. File level metadata unlocks the power of existing archives and metadata repositories such as ECS and CMR and search and discovery utilities like Reverb and Earth Data Search. Current missions now using SIPSMetGen include: Aquarius, Measures, ARISE, and Nimbus.

Two types of phytases (histidine acid phytase and β-propeller phytase) in Serratia sp. TN49 from the gut of Batocera horsfieldi (coleoptera) larvae.

Science.gov (United States)

Zhang, Rui; Yang, Peilong; Huang, Huoqing; Shi, Pengjun; Yuan, Tiezheng; Yao, Bin

2011-11-01

Microbial phytases play a major role in the mineralization of organic phosphorous, especially in symbiotic plants and animals. In this study, we identified two types of phytases in Serratia sp. TN49 that was harbored in the gut of Batocera horsfieldi (Coleoptera) larvae. The two phytases, an acidic histidine acid phosphatase (PhyH49) and an alkaline β-propeller phytase (PhyB49), shared low identities with known phytases (61% at most). PhyH49 and PhyB49 produced in Escherichia coli exhibited maximal activities at pH 5.0 (60°C) and pH 7.5-8.0 (45°C), respectively, and are complementary in phytate degradation over the pH range 2.0-9.0. Serratia sp. TN49 harboring both PhyH49 and PhyB49 might make it more adaptive to environment change, corresponding to the evolution trend of microorganism.

The complete sequence and comparative analysis of a multidrug- resistance and virulence multireplicon IncFII plasmid pEC302/04 from an extraintestinal pathogenic Escherichia coli EC302/04 indicate extensive diversity of IncFII plasmids

Directory of Open Access Journals (Sweden)

Wing Sze eHo

2016-01-01

Full Text Available Extraintestinal pathogenic Escherichia coli (ExPEC that causes extraintestinal infections often harbor plasmids encoding fitness traits such as resistance and virulence determinants that are of clinical importance. We determined the complete nucleotide sequence of plasmid pEC302/04 from a multidrug-resistant E. coli EC302/04 which was isolated from the tracheal aspirate of a patient in Malaysia. In addition, we also performed comparative sequence analyses of 18 related IncFIIA plasmids to determine the phylogenetic relationship and diversity of these plasmids. The 140,232 bp pEC302/04 is a multireplicon plasmid that bears three replication systems (FII, FIA and FIB with subtype of F2:A1:B1. The plasmid is self-transmissible with a complete transfer region. pEC302/04 also carries antibiotic resistance genes such as blaTEM-1 and a class I integron containing sul1, cml and aadA resistance genes, conferring multidrug resistance (MDR to its host, E. coli EC302/04. Besides, two iron acquisition systems (SitABCD and IutA-IucABCD which are the conserved virulence determinants of ExPEC-colicin V or B and M (ColV/ColBM-producing plasmids were identified in pEC302/04. Multiple toxin-antitoxin (TA-based addiction systems (i.e., PemI/PemK, VagC/VagD, CcdA/CcdB, and Hok/Sok and a plasmid partitioning system, ParAB and PsiAB, which are important for plasmid maintenance were also found.Comparative plasmid analysis revealed only one conserved gene, the repA1 as the core genome, showing that there is an extensive diversity among the IncFIIA plasmids. The phylogenetic relationship of 18 IncF plasmids based on the core regions revealed that ColV/ColBM-plasmids and non-ColV/ColBM plasmids were separated into two distinct groups. These plasmids, which carry highly diverse genetic contents, are also mosaic in nature. The atypical combination of genetic materials, i.e., the MDR- and ColV/ColBM-plasmid-virulence encoding regions in a single ExPEC plasmid is rare but of

The Complete Sequence and Comparative Analysis of a Multidrug-Resistance and Virulence Multireplicon IncFII Plasmid pEC302/04 from an Extraintestinal Pathogenic Escherichia coli EC302/04 Indicate Extensive Diversity of IncFII Plasmids.

Science.gov (United States)

Ho, Wing Sze; Yap, Kien-Pong; Yeo, Chew Chieng; Rajasekaram, Ganeswrie; Thong, Kwai Lin

2015-01-01

Extraintestinal pathogenic Escherichia coli (ExPEC) that causes extraintestinal infections often harbor plasmids encoding fitness traits such as resistance and virulence determinants that are of clinical importance. We determined the complete nucleotide sequence of plasmid pEC302/04 from a multidrug-resistant E. coli EC302/04 which was isolated from the tracheal aspirate of a patient in Malaysia. In addition, we also performed comparative sequence analyses of 18 related IncFIIA plasmids to determine the phylogenetic relationship and diversity of these plasmids. The 140,232 bp pEC302/04 is a multireplicon plasmid that bears three replication systems (FII, FIA, and FIB) with subtype of F2:A1:B1. The plasmid is self-transmissible with a complete transfer region. pEC302/04 also carries antibiotic resistance genes such as bla TEM-1 and a class I integron containing sul1, cml and aadA resistance genes, conferring multidrug resistance (MDR) to its host, E. coli EC302/04. Besides, two iron acquisition systems (SitABCD and IutA-IucABCD) which are the conserved virulence determinants of ExPEC-colicin V or B and M (ColV/ColBM)-producing plasmids were identified in pEC302/04. Multiple toxin-antitoxin (TA)-based addiction systems (i.e., PemI/PemK, VagC/VagD, CcdA/CcdB, and Hok/Sok) and a plasmid partitioning system, ParAB, and PsiAB, which are important for plasmid maintenance were also found. Comparative plasmid analysis revealed only one conserved gene, the repA1 as the core genome, showing that there is an extensive diversity among the IncFIIA plasmids. The phylogenetic relationship of 18 IncF plasmids based on the core regions revealed that ColV/ColBM-plasmids and non-ColV/ColBM plasmids were separated into two distinct groups. These plasmids, which carry highly diverse genetic contents, are also mosaic in nature. The atypical combination of genetic materials, i.e., the MDR- and ColV/ColBM-plasmid-virulence encoding regions in a single ExPEC plasmid is rare but of clinical

Isolation and characterization of Tn917lac-generated competence mutants of Bacillus subtilis

International Nuclear Information System (INIS)

Hahn, J.; Albano, M.; Dubnau, D.

1987-01-01

The authors isolated 28 mutants of Bacillus subtilis deficient in the development of competence by using the transposon Tn917lacZ as a mutagen. The mutant strains were poorly transformable with plasmid and chromosomal DNAs but were normally transducible and exhibited wild-type resistance to DNA-damaging agents. The mutations were genetically mapped, and the mutants were characterized with respect to their abilities to bind and take up radiolabeled DNA. All were defective in uptake, and some failed to bind significantly amounts of DNA. The abilities of the mutant strains to resolve into two buoyant density classes on Renografin gradients were studied. Most resolved normally, but several banded in Renografin only at the buoyant density of noncompetent cells. The genetic mapping studies and the other analyses suggested that the mutations define a minimum of seven distinct com genes

Artificial intelligence in process control: Knowledge base for the shuttle ECS model

Science.gov (United States)

Stiffler, A. Kent

1989-01-01

The general operation of KATE, an artificial intelligence controller, is outlined. A shuttle environmental control system (ECS) demonstration system for KATE is explained. The knowledge base model for this system is derived. An experimental test procedure is given to verify parameters in the model.

Discrimination between Native and Tn6010-Associated oqxAB in Klebsiella spp., Raoultella spp., and other Enterobacteriaceae by Using a Two-Step Strategy

DEFF Research Database (Denmark)

Guillard, Thomas; Lebreil, Anne-Laure; Hansen, Lars Hestbjerg

2015-01-01

ABSTRACT We developed a two-step PCR-based strategy to detect genes encoding OqxAB, allowing a specific assignment of Tn6010-associated oqxAB in Enterobacteriaceae. Chromosomal location in this setup was confirmed by hybridization with I-CeuI-restricted genomes. This approach led us to find...

EC + LH current drive efficiency in the presence of an internal transport barrier

International Nuclear Information System (INIS)

Rosa, P.R. da S; Ziebell, L.F.

2002-01-01

In this paper we study the effects of the presence of an internal transport barrier (ITB) on the current drive efficiency and power deposition profiles in the case of electron cyclotron waves interacting with an extended tail generated by lower hybrid (LH) waves. We study the subject by numerically solving the Fokker-Planck equation, with temperature and density profiles corrected along the time evolution at each collision time, based on the actual time-evolving electron distribution function. The results obtained show that the LH and electron cyclotron (EC) power absorption profiles and the current driven by the combined action of both types of waves are weakly dependent on the depth of the ITB, slightly more dependent on the level of magnetic turbulence and much more dependent on the level of EC wave power. (author)

Loading and transport of high-active waste (HAW) with the TN85 flask in 2008

International Nuclear Information System (INIS)

Rys, Michael; Horn, Thomas; Graf, Wilhelm; Bonface, Jean-Michael

2009-01-01

As a part of the operation of nuclear power plants, it is essential to safely manage the radioactive waste. With new developments in science and technology, it is a dynamic process to adapt procedures, equipment and flasks to be used in the future. This is a task for specialists - a task for GNS Gesellschaft fuer Nuklear-Service mbH and for TN International. Until 1994 reprocessing of spent fuel from German nuclear power plants was mandatory for the Utilities (EVU) in Germany. Basis for the reprocessing was the German Atomic Act. The German Utilities concluded contracts on reprocessing with Compagnie Generale des Matieres Nucleaires (COGEMA, now AREVA NC) in France and British Nuclear Fuels plc (BNFL, now INS) in England. The total amount to be reprocessed comes to 5309 t HM contracted to AREVA NC and 768 t HM contracted to INS. The waste generated from reprocessing - or an equivalent amount of radioactive material - has to be returned to the country of origin. In 1979 already an exchange of notes took place between the German and the French government with the obligation of both sides to enable and support the return of reprocessing residues or equivalents. The return of high-active waste (HAW) from France has started in 1996 with the first attribution of 28 glass canisters (one flask) to German Utilities by AREVA NC. Until 2007, 75 flasks loaded with vitrified residue (VR) canisters have been transported to Gorleben. For these transports CASTOR registered HAW 20/28 CG flasks have been used. This presentation will give some background information about the last HAW transport in 2008 with the new flask generation of the type TN85. It will also describe the assembly of the new flask, the preparation of the flask for the loading campaign as well as the loading procedure. (orig.)

Loading and transport of high-active waste (HAW) with the TN85 flask in 2008

Energy Technology Data Exchange (ETDEWEB)

Rys, Michael; Horn, Thomas; Graf, Wilhelm [GNS Gesellschaft fuer Nuklear-Service mbH (Germany); Bonface, Jean-Michael [TN International, Montigny-le-Bretonneux (France)

2009-07-01

As a part of the operation of nuclear power plants, it is essential to safely manage the radioactive waste. With new developments in science and technology, it is a dynamic process to adapt procedures, equipment and flasks to be used in the future. This is a task for specialists - a task for GNS Gesellschaft fuer Nuklear-Service mbH and for TN International. Until 1994 reprocessing of spent fuel from German nuclear power plants was mandatory for the Utilities (EVU) in Germany. Basis for the reprocessing was the German Atomic Act. The German Utilities concluded contracts on reprocessing with Compagnie Generale des Matieres Nucleaires (COGEMA, now AREVA NC) in France and British Nuclear Fuels plc (BNFL, now INS) in England. The total amount to be reprocessed comes to 5309 t HM contracted to AREVA NC and 768 t HM contracted to INS. The waste generated from reprocessing - or an equivalent amount of radioactive material - has to be returned to the country of origin. In 1979 already an exchange of notes took place between the German and the French government with the obligation of both sides to enable and support the return of reprocessing residues or equivalents. The return of high-active waste (HAW) from France has started in 1996 with the first attribution of 28 glass canisters (one flask) to German Utilities by AREVA NC. Until 2007, 75 flasks loaded with vitrified residue (VR) canisters have been transported to Gorleben. For these transports CASTOR {sup registered} HAW 20/28 CG flasks have been used. This presentation will give some background information about the last HAW transport in 2008 with the new flask generation of the type TN85. It will also describe the assembly of the new flask, the preparation of the flask for the loading campaign as well as the loading procedure. (orig.)

Integration of the market of the European Community and the change of the industrial structure; EC shijo togo to sangyo kozo no henka

Energy Technology Data Exchange (ETDEWEB)

Nakamura, T; Uno, K; Tanimoto, T; Yamashita, T [Osaka Sangyo University, Osaka (Japan). Institute for Industrial Research

1994-11-22

This paper describes progress of the cooperation as to the integration of EC market and the change of industrial structure. For the structural change in the industry and economy accompanied by the integration of EC, effects of the Maastricht Treaty on the economic structure of EC are described. It is considered that the EC countries are affected by the political and economical restrictions due to the agreement of this treaty. For the change in the distribution structure accompanied by the integration of EC, obstruction factors of the deregulation of EC transportation market are especially investigated. Differences in the distribution capacity, various regulations and standards, and labor condition among individual countries are pointed out as the obstruction factors. For the unity of Germany and its economical and administrative influence, various problems are pointed out as to the economical confusion, progress in the de-nationalization of enterprises, management of real estate and land, etc. For the structural change in the road freight market in the member nations of EC, the structure of road freight market is made clear for the previous West Germany before the integration of European market. It is confirmed that the internationalization of the German domestic market is being promoted.

Search for EC-decayed neutron-deficient actinide isotopes using gas-jet coupled JAERI-ISOL

Energy Technology Data Exchange (ETDEWEB)

Tsukada, Kazuaki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1997-07-01

To study the nuclear properties of unknown neutron deficient actinide isotopes which decay mainly via orbital electron capture (EC), we have developed a composite system consisting of a gas-jet transport apparatus and a thermal ion-source at the JAERI-ISOL. With this system, search for {sup 236}Am produced in the {sup 235}U({sup 6}Li, 5n) reaction has been performed. Pu KX-rays associated with the EC decay of {sup 236}Am are observed at the mass-236 fraction. The half-life of {sup 236}Am is evaluated to be 4.4min. The outline of the gas-jet coupled JAERI-ISOL system and typical performance are given. (author)

Sbírka rukopisných zlomků ve Státním okresním archivu v Kutné Hoře

Czech Academy of Sciences Publication Activity Database

Brodský, Pavel; Hradilová, Marta; Hrdinová, Martina; Petr, Stanislav; Tošnerová, Marie

2013-01-01

Roč. 43, č. 0 (2013), s. 207-248 ISSN 0585-5691 R&D Projects: GA ČR GAP405/10/0027 Institutional support: RVO:67985921 Keywords : codicology * manuscripts fragments * Státní okresní archiv Kutná Hora Subject RIV: AB - History

40 CFR Table 3 to Subpart Ec of... - Operating Parameters To Be Monitored and Minimum Measurement and Recording Frequencies

Science.gov (United States)

2010-07-01

... Which Construction is Commenced After June 20, 1996 Pt. 60, Subpt. Ec, Table 3 Table 3 to Subpart Ec of... Operating parameters to be monitored Minimum frequency Data measurement Data recording Control system Dry scrubber followed by fabric filter Wet scrubber Dry scrubber followed by fabric filter and wet scrubber...

Open Circuit Resonant (SansEC) Sensor Technology for Lightning Mitigation and Damage Detection and Diagnosis for Composite Aircraft Applications

Science.gov (United States)

Szatkowski, George N.; Dudley, Kenneth L.; Smith, Laura J.; Wang, Chuantong; Ticatch, Larry A.

2014-01-01

Traditional methods to protect composite aircraft from lightning strike damage rely on a conductive layer embedded on or within the surface of the aircraft composite skin. This method is effective at preventing major direct effect damage and minimizes indirect effects to aircraft systems from lightning strike attachment, but provides no additional benefit for the added parasitic weight from the conductive layer. When a known lightning strike occurs, the points of attachment and detachment on the aircraft surface are visually inspected and checked for damage by maintenance personnel to ensure continued safe flight operations. A new multi-functional lightning strike protection (LSP) method has been developed to provide aircraft lightning strike protection, damage detection and diagnosis for composite aircraft surfaces. The method incorporates a SansEC sensor array on the aircraft exterior surfaces forming a "Smart skin" surface for aircraft lightning zones certified to withstand strikes up to 100 kiloamperes peak current. SansEC sensors are open-circuit devices comprised of conductive trace spiral patterns sans (without) electrical connections. The SansEC sensor is an electromagnetic resonator having specific resonant parameters (frequency, amplitude, bandwidth & phase) which when electromagnetically coupled with a composite substrate will indicate the electrical impedance of the composite through a change in its resonant response. Any measureable shift in the resonant characteristics can be an indication of damage to the composite caused by a lightning strike or from other means. The SansEC sensor method is intended to diagnose damage for both in-situ health monitoring or ground inspections. In this paper, the theoretical mathematical framework is established for the use of open circuit sensors to perform damage detection and diagnosis on carbon fiber composites. Both computational and experimental analyses were conducted to validate this new method and system for

Two investigations concerning the release of tritium. I. Tritium leakage from 3H(Sc) EC-detectors

International Nuclear Information System (INIS)

Bergman, C.; Wesslen, E.

1977-01-01

Recently the manufacturers of EC-detectors for gas chromatographs introduced a new type of 3 H EC-detector where the tritium is bound to scandium instead of to titanium and has an activity up to 1 Ci. It is expected that the scandium-based detector will take a great part of the Swedish EC-detector market. The Swedish National Institute of Radiation Protection is anxious to make sure that the introduction of the new detector, which will be used at higher temperature, will not give rise to any increased risk of tritium intake to the personnel handling the chromatographs. The leakage of tritium from commercially available 3 H(Sc) EC-detectors containing 1 Ci of tritium was measured as a function of the detector temperature. Tritium appears both in the form of tritium gas dissolved in the scandium and in the form of tritide. The gas evaporates rather easily with increasing temperature while the dissociation of the tritide is a slower process. The evaporation of tritium due to the dissociation of the tritide was found to be negligible, less than 0.2 μCi/h at temperatures less than 100 0 C, but rises rapidly with temperature. The study also showed that even when the detector is stored at room temperature, a re-distribution of the tritium occures, from the tritide to the dissolved tritium gas, which then easily evaporates even at moderately elevated temperatures

Technology Transfer Bottlenecks and Lessons Learned in Humanitarian Demining EU-funded Research: Analysis and Results from the EC DELVE Project

International Nuclear Information System (INIS)

Bruschini, C.; Sahli, H.; Van Kempen, L.; Schleijpen, R.; Breejen, E. den

2010-01-01

The EC DELVE Support Action (www.delve.vub.ac.be) has analyzed the bottlenecks in the transfer of Humanitarian Demining (HD) technology from technology development to the use in the field, basing itself on the assessment of the European HD Research and Technology Development (RTD) situation from early 1990 until 2006. The developments in HD during the last 10 years underline the fact that in a number of cases demining related developments have been terminated or at least put on hold. A number of lessons learned were drawn, bottlenecks identified and broadly classified as either Confidence, Cost, or Communication related. The study also showed that the funding provided by the European Commission (EC) has led directly to the creation of an extensive portfolio of HD technology development projects. However, the range of instruments available to the EC to finance the necessary R and D was limited to pre-competitive research. The EC had no tools or programs to fund actual product development. The corresponding consequences are detailed in the study. The separation of the Mine Action and RTD funding streams in the EC did also negatively affect the take-up of new technologies. As a main conclusion, creating coherence between: (1) the EC policy based on political decisions, (2) RTD, testing and industrialization of equipment, and (3) timely deployment, requires a new way of coordinated thinking: 'end-to-end planning' has to be supported by a well organized and coordinated organizational structure involving different DGs (Directorate General) and even extending beyond the EU. This was not the case for Mine Action. (author)

Judicial Protection in the Field of Public Procurement: The Transposition into Dutch Law of Directive 2007/66/EC Amending the Remedies Directives

Directory of Open Access Journals (Sweden)

Wouter-Jan Berends

2010-08-01

Full Text Available Public procurement procedures in the EU are coordinated by Directives 2004/17/EC and 2004/18/EC. The acquis communautaire provides minimum requirements for review procedures against public procurement decisions in order to ensure access to effective remedies for economic operators. These minimum requirements are established in Directives 89/665/ EEC and 92/13/EEC and recently amended by Directive 2007/66/EC. The Helby report identified several substantive concerns over the Dutch proposal on the implementation the of the Remedies Directive; Wet implementatie rechtsbeschermingsrichtlijnen. Although the transposition target date has not been met, the Dutch legislature has succeeded to transpose Directive 2007/66/EC into Dutch law while addressing the concerns of the Helby report.

Swedish healthcare providers' perceptions of preconception expanded carrier screening (ECS)-a qualitative study.

Science.gov (United States)

Matar, A; Kihlbom, U; Höglund, A T

2016-07-01

Reproductive autonomy, medicalization, and discrimination against disabled and parental responsibility are the main ongoing ethical debates concerning reproductive genetic screening. To examine Swedish healthcare professionals' views on preconception expanded carrier screening (ECS), a qualitative study involving academic and clinical institutions in Sweden was conducted in September 2014 to February 2015. Eleven healthcare professionals including clinicians, geneticists, a midwife, and a genetic counselor were interviewed in depth using a semi-structured interview guide. The questionnaire was constructed after reviewing the main literature and meetings with relevant healthcare providers. The interviews were recorded, transcribed verbatim, and content analyzed for categories and subcategories. Participants nurtured many ethical and non-ethical concerns regarding preconception ECS. Among the ethical concerns were the potential for discrimination, medicalization, concerns with prioritization of healthcare resources, and effects on reproductive freedom. The effects of implementation of preconception ECS, its stakeholders, regulations, and motivation are some of non-ethical concerns. These concerns, if not addressed, may affect the uptake and usage of carrier screening within Swedish healthcare system. As this is a qualitative study with a small non-random sample size, the findings cannot be generalized. The participants had little to no working experience with expanded screening panels. Moreover, the interviews were conducted in English, a second language for the participants, which might have limited the expression of their views. However, the authors claim that the findings may be pertinent to similar settings in other Scandinavian countries.

Environmental Quality Standards in the EC-Water Framework Directive

DEFF Research Database (Denmark)

Jirka, Gerhard H.; Burrows, Richard; Larsen, Torben

2004-01-01

The "combined approach" in the new EC-Water Framework Directive(WFD) consisting of environmental quality standards in addition to emission limit values promises improvements in the quality characteristics of surface water. However, the specification of where in the water body the environmental...... quality standards apply is missing in the WFD. The omission will limit its administrative implementation. A clear mixing zone regulation is needed so that the quality objectives of the WFD are not jeopardized. This need is demonstrated using the examples of point source discharges into rivers and coastal...

Translation, data quality, reliability, validity and responsiveness of the Norwegian version of the Effective Musculoskeletal Consumer Scale (EC-17

Directory of Open Access Journals (Sweden)

Kristjansson Elizabeth

2010-01-01

Full Text Available Abstract Background The Effective Musculoskeletal Consumer Scale (EC-17 is a self-administered questionnaire for evaluating self-management interventions that empower and educate people with rheumatic conditions. The aim of the study was to translate and evaluate the Norwegian version of EC-17 against the necessary criteria for a patient-reported outcome measure, including responsiveness to change. Methods Data quality, reliability, validity and responsiveness were assessed in two groups. One group comprising 103 patients received a questionnaire before and at the end of a self-management programme. The second group comprising 96 patients' received the questionnaire two weeks before and on arrival of the program. Internal consistency and test-retest reliability were assessed. Construct validity was assessed through comparisons with the Brief Approach/Avoidance Coping Questionnaire, (BACQ, the Emotional Approach Coping Scale (EAC and the General Health Questionnaire (GHQ-20. Responsiveness was assessed with the Standardised Response Mean (SRM. Results Respondents included 66 (64% and 52 (54% patients from the first and second groups respectively. Levels of missing data were low for all items. There was good evidence for unidimensionality, item-total correlations ranged from 0.59 to 0.82 and Cronbach's Alpha and test-retest correlations were over 0.90. As hypothesised EC-17 scores had statistically significant low to moderate correlations with the BACQ, EAC and GHQ-20 in the range 0.26 to 0.42. Following the self-management program, EC-17 scores showed a significant improvement with an SRM of 0.48. Conclusion The Norwegian version of the EC-17 has evidence for data quality, internal consistency and test-retest reliability, construct validity and responsiveness to change. The EC-17 seems promising as an outcome measure for evaluating self-management interventions for people with rheumatic conditions, but further studies are needed.

Translation, data quality, reliability, validity and responsiveness of the Norwegian version of the Effective Musculoskeletal Consumer Scale (EC-17).

Science.gov (United States)

Hamnes, Bente; Garratt, Andrew; Kjeken, Ingvild; Kristjansson, Elizabeth; Hagen, Kåre B

2010-01-29

The Effective Musculoskeletal Consumer Scale (EC-17) is a self-administered questionnaire for evaluating self-management interventions that empower and educate people with rheumatic conditions. The aim of the study was to translate and evaluate the Norwegian version of EC-17 against the necessary criteria for a patient-reported outcome measure, including responsiveness to change. Data quality, reliability, validity and responsiveness were assessed in two groups. One group comprising 103 patients received a questionnaire before and at the end of a self-management programme. The second group comprising 96 patients' received the questionnaire two weeks before and on arrival of the program. Internal consistency and test-retest reliability were assessed. Construct validity was assessed through comparisons with the Brief Approach/Avoidance Coping Questionnaire, (BACQ), the Emotional Approach Coping Scale (EAC) and the General Health Questionnaire (GHQ-20). Responsiveness was assessed with the Standardised Response Mean (SRM). Respondents included 66 (64%) and 52 (54%) patients from the first and second groups respectively. Levels of missing data were low for all items. There was good evidence for unidimensionality, item-total correlations ranged from 0.59 to 0.82 and Cronbach's Alpha and test-retest correlations were over 0.90. As hypothesised EC-17 scores had statistically significant low to moderate correlations with the BACQ, EAC and GHQ-20 in the range 0.26 to 0.42. Following the self-management program, EC-17 scores showed a significant improvement with an SRM of 0.48. The Norwegian version of the EC-17 has evidence for data quality, internal consistency and test-retest reliability, construct validity and responsiveness to change. The EC-17 seems promising as an outcome measure for evaluating self-management interventions for people with rheumatic conditions, but further studies are needed.

The Advanced Petroleum-Based Fuels Program Evaluation of EC-Diesel and Diesel Particulate Filters in Southern California Vehicle Fleets

International Nuclear Information System (INIS)

None

2000-01-01

The EC-Diesel and particulate filter combination greatly reduced the particulate matter, hydrocarbon, and carbon monoxide emissions of all vehicles tested in the program to date. Particulate matter reductions greater than 98% were achieved. For several vehicles tested, the PM and HC emissions were less than background levels. Based on preliminary statistical analysis, there is 95%+ confidence that EC-D and particulate filters reduced emissions from three different types of vehicles. A fuel consumption penalty was not detectable using the current test procedures and chassis dynamometer laboratory. Test vehicles equipped with the CRT and DPX particulate filters and fueled with EC-Diesel fuel have operated reliably during the program start-up period

Drum rotor blowers in EC technology. Energy conservation, comfortable control, low noise; Trommellaeufer-Ventilatoren in EC-Technik. Energieersparnis, komfortable Regelung und geringe Geraeuschentwicklung

Energy Technology Data Exchange (ETDEWEB)

Sigloch, U. [ebm-papst Mulfingen GmbH und Co. KG (Germany). Projektmanagement Vertrieb Europa; Reiff, E.C. [Redaktionsbuero Stutensee (Germany)

2008-07-01

Compact drum rotor blowers with forward-curved blades are quite common in air conditioning and ventilation because of their high efficiency and compact dimensions. They are found in air conditioner boxes, in air current systems in department stores, or in fan coils in hotel rooms, wherever other types of blowers would be too big. Until recently, EC technology was not available for the blower motors so the users had do accept low efficiency and the poor control options of conventional AC drives. This has changed by now. (orig.)

Effect of different concentration of actellic 25ec on the storage quality ...

African Journals Online (AJOL)

The experiment was conducted at the Pest Management Laboratory of Niger State College of Agriculture, Mokwa, during December, 2009 and June, 2010 to identify the most effective and economic dosage of Actellic 25EC for successful preservation of quality of cowpea for about six month after harvesting. The treatments ...

Safety controls according to the non-proliferation treaty in EC countries

International Nuclear Information System (INIS)

Pander, J. von.

1978-01-01

Above all, content and extent of the duty conferred upon the IAEA according to article III, paragraph 1 of the NP treaty which implies the conducting of safety controls and the consequences resulting here from are examined. Including the peaceful use of nuclear energy developing under international law the agreement on safety control signed on 5th April 1973 between IAEA and EURATOM as well as its seven non-nuclear-weapon member states is discussed, along with its technical and its implicit legal problems. In detail the manifold technical and judicial problems of IAEA safety controls are shown, their realization requiring a well-working cooperation between IAEA and the European Communities. As only the non-nuclear-weapon member states of the EC are subject to the IAEA safety control system within the frame of this agreement the following questions are discussed: 1. effects on the member status after the signing of the EURATOM contract and 2. granting the principle of equal treatment for all member states as against the nuclear-weapon member states of the EC, France and the United Kingdom. (orig./HP) [de

Effects of short-term tocopherol (T) feeding on structure-localized protein tyrosine nitration (pTN) patterns of mitochondrial ATPase following endotoxin (LPS) challenge in beef calves.

Science.gov (United States)

Mitochondrial ATPase/Complex-V (MCV) is an electron transport chain (ETC) component needed for ATP synthesis. The ETC, exquisitely sensitive to proinflammatory mediators (PIM), generates oxynitrogen reactants leading to pTN formation as mitochondrial membrane leakage occurs. Immunohistochemical loca...

The environmental policy of the EC. An analysis exemplified by air pollution abatement policy

International Nuclear Information System (INIS)

Caspari, S.

1995-01-01

Since the early seventies the European Community has reacted to increasing ecological damage with complex and comprehensive common environmental policies. In this study, the author analyzes and evaluates the theoretical conception and the instrumental application of the EC Environmental Policy using four criteria: (1) Ecological effectiveness, (2) economic efficiency, (3) conformity with a market order - viewpoint of 'Ordnungspolitik', (4) 'sustainability'. The study shows that there is a large discrepancy between the demands and the reality of the EC Environmental Policy. In addition to grave ecological deficiencies it reveals an increse in rent-seeking activities and an interventionist trend which have resulted in the erosion of the competitive incentive system of the market order in the Community. In view of various deficits the author perceives a basic 'regulation paradox' and a 'policy failure'. Based on a diagnosis of the causes of these deficiencies, he outlines some proposals for a reform of the EC Environmental Policy, indicating that a central prerequisite for a more effective and efficient environmental protection is a reorientation in the system ('Ordnungspolitik') which determines the common Environmental Policy. In addition, he maintains that in view of the clear asymmetry in the representation of interests in favour of particularist interests it is necessary to strengthen public interest in order to enable a more effective protection of the options future generations will have regarding their lives and their behaviour. (orig.) [de

Mid-infrared spectroscopic characterisation of an ultra-broadband tunable EC-QCL system intended for biomedical applications

Science.gov (United States)

Vahlsing, T.; Moser, H.; Grafen, M.; Nalpantidis, K.; Brandstetter, M.; Heise, H. M.; Lendl, B.; Leonhardt, S.; Ihrig, D.; Ostendorf, A.

2015-07-01

Mid-infrared spectroscopy has been successfully applied for reagent-free clinical chemistry applications. Our aim is to design a portable bed-side system for ICU patient monitoring, based on mid-infrared absorption spectra of continuously sampled body-fluids. Robust and miniature bed-side systems can be achieved with tunable external cavity quantum cascade lasers (EC-QCL). Previously, single EC-QCL modules covering a wavenumber interval up to 250 cm-1 have been utilized. However, for broader applicability in biomedical research an extended interval around the mid-infrared fingerprint region should be accessible, which is possible with at least three or four EC-QCL modules. For such purpose, a tunable ultra-broadband system (1920 - 780 cm-1, Block Engineering) has been studied with regard to its transient emission characteristics in ns time resolution during different laser pulse widths using a VERTEX 80v FTIR spectrometer with step-scan option. Furthermore, laser emission line profiles of all four incorporated EC-QCL modules have been analysed at high spectral resolution (0.08 cm-1) and beam profiles with few deviations from the TEM 00 spatial mode have been manifested. Emission line reproducibility has been tested for various wavenumbers in step tune mode. The overall accuracy of manufacturer default wavenumber setting has been found between ± 3 cm-1 compared to the FTIR spectrometer scale. With regard to an application in clinical chemistry, theoretically achievable concentration accuracies for different blood substrates based on blood plasma and dialysate spectra previously recorded by FTIRspectrometers have been estimated taking into account the now accessible extended wavenumber interval.

HTR-TN a European network for the development of HTR technology

International Nuclear Information System (INIS)

Von Lensa, W.

2001-01-01

A network called High-temperature reactor technology network (HTR-TN) has been created at a European level to coordinate works and knowledge on the subject with a long-term perspective and to serve as a channel for international collaboration. An analysis confirmed that the obvious economic penalty of HTR due to its low density power could be compensated by the combination of recent advances that may completely change the positioning of HTR on the energy market: -) the modular concept allowed to get a reactor free from core melt risk without intervention of any active safety system, implying a drastic simplification of the design of the reactor and the safety systems as well as a standardisation and potential for shop fabrication in series; -) the development of gas turbines, the efficiency of which increased, in 10 years, from 35% till 50% and more, enabling to consider suppression of the secondary system; -) the ultra high burn-up potential of HTR fuel and the possibility for direct disposal of spent HTR fuel elements that may reduce cost of the fuel cycle and contribute to the reduction of civil and military plutonium stockpiles. (A.C.)

Should there be an EC carbon/energy tax?

International Nuclear Information System (INIS)

Helm, D.

1993-01-01

The European Commission has suggested that an EC-wide carbon/energy tax should be introduced to meet the Community's commitment to reduce emissions of carbon dioxide, and to bear down on criticisms of sulphur dioxide and other harmful energy externalities. The UK government to data has pursued at best an agnostic position. Although the White Paper, This Common Inheritance, (DOE, 1990) gave prominence to the use of market-based instruments in advancing environmental objectives, their use in air pollution has been limited to the tax differential on unleaded petrol, the commitment to increase petrol tax in real terms in successive budgets and the imposition of VAT on domestic fuel in a phased series of stages. (Author)

Should there be an EC carbon/energy tax

Energy Technology Data Exchange (ETDEWEB)

Helm, D. (New College, Oxford (United Kingdom))

1993-12-01

The European Commission has suggested that an EC-wide carbon/energy tax should be introduced to meet the Community's commitment to reduce emissions of carbon dioxide, and to bear down on criticisms of sulphur dioxide and other harmful energy externalities. The UK government to data has pursued at best an agnostic position. Although the White Paper, This Common Inheritance, (DOE, 1990) gave prominence to the use of market-based instruments in advancing environmental objectives, their use in air pollution has been limited to the tax differential on unleaded petrol, the commitment to increase petrol tax in real terms in successive budgets and the imposition of VAT on domestic fuel in a phased series of stages. (Author)

Fingerprints of field-induced Berezinskii–Kosterlitz–Thouless transition in quasi-two-dimensional S=1/2 Heisenberg magnets Cu(en)(H{sub 2}O){sub 2}SO{sub 4} and Cu(tn)Cl{sub 2}

Energy Technology Data Exchange (ETDEWEB)

Baranová, Lucia [Civil Engineering Faculty, Department of Applied Mathematics, Technical University of Košice, Vysokoškolská 4 SK-042 00, Košice (Slovakia); Orendáčová, Alžbeta, E-mail: alzbeta.orendacova@upjs.sk [Center of Low Temperature Physics, Faculty of Science, P. J. Šafárik University, Park Angelinum 9 SK-041 54, Košice (Slovakia); Čižmár, Erik [Center of Low Temperature Physics, Faculty of Science, P. J. Šafárik University, Park Angelinum 9 SK-041 54, Košice (Slovakia); Tarasenko, Róbert; Tkáč, Vladimír [Center of Low Temperature Physics, Faculty of Science, P. J. Šafárik University, Park Angelinum 9 SK-041 54, Košice (Slovakia); Charles University, Faculty of Mathematics and Physics, Ke Karlovu 5 12116, Prague (Czech Republic); Orendáč, Martin; Feher, Alexander [Center of Low Temperature Physics, Faculty of Science, P. J. Šafárik University, Park Angelinum 9 SK-041 54, Košice (Slovakia)

2016-04-15

Organo-metallic compounds Cu(en)(H{sub 2}O){sub 2}SO{sub 4} (en=C{sub 2}H{sub 8}N{sub 2}) and Cu(tn)Cl{sub 2} (tn=C{sub 3}H{sub 10}N{sub 2}) representing S=1/2 quasi-two-dimensional Heisenberg antiferromagnets with an effective intra-layer exchange coupling J/k{sub B}≈3 K, have been examined by specific heat measurements at temperatures down to nominally 50 mK and magnetic fields up to 14 T. A comparative analysis of magnetic specific heat in zero magnetic field revealed nearly identical contribution of short-range magnetic correlations and significant differences were observed at lowest temperatures. A phase transition to long-range order was observed in Cu(en)(H{sub 2}O){sub 2}SO{sub 4} at T{sub C}=0.9 K while hidden in Cu(tn)Cl{sub 2}. A response of both compounds to the application of magnetic field has rather universal features characteristic for a field-induced Berezinskii–Kosterlitz–Thouless transition theoretically predicted for ideal two-dimensional magnets. - Highlights: • Magnetic specific heat of Cu(en)(H{sub 2}O){sub 2}SO{sub 4} (1) and Cu(tn)Cl{sub 2} (2) was analysed. • In zero magnetic field, (1) and (2) behave as quasi-two-dimensional magnets. • We observed universal thermodynamic response of (1) and (2) to applied field. • Features of field-induced Berezinskii–Kosterlitz–Thouless transition were detected.

Economic and legal problems arising in connection with an EC tax on carbon dioxide emissions

International Nuclear Information System (INIS)

Ressing, W.

1993-01-01

Having regard to maintaining the competitiveness of the German industry, the German Federal Government decided not to start a solo attempt with introducing in Germany a tax on CO 2 emissions, but instead is backing a proposed directive of the EC Commission, suggesting such tax to be established in the EC member states. There are various concepts on the table open for debate, intended to safeguard competitiveness of the industries by a mix of principles including e.g.: conditionality, the tax to be neutral in its effect on revenue, conditions for tax relieves for energy-intensive business, and tax relieves for investment into technologies and equipment for CO 2 abatement. (orig.) [de

Real time control of the sawtooth period using EC launchers

International Nuclear Information System (INIS)

Paley, J I; Felici, F; Coda, S; Goodman, T P; Piras, F

2009-01-01

Tokamak plasmas operating at high performance are limited by several MHD instabilities. The sawtooth instability limits the core plasma pressure and can drive the neoclassical tearing mode unstable, but also prevents accumulation of impurities in the core. Electron cyclotron heating and current drive systems can be used to modify the local current profile and therefore tailor the sawtooth period. This paper reports on demonstrations of continuous real time feedback control of the sawtooth period by varying the EC injection angle.

Integrated pretreatment and desalination by electrocoagulation (EC)-ion concentration polarization (ICP) hybrid.

Science.gov (United States)

Choi, Siwon; Kim, Bumjoo; Han, Jongyoon

2017-06-13

Conventional water treatment process is composed of multiple stages, including desalination (salt removal) and pre/post-treatment of desalination to remove particles, chemicals, and other potential foulants for desalination. In this work, we developed a microfluidic proof-of-concept for a single device water treatment system, which removes both salt ions and non-salt contaminants. Our system combines electrocoagulation (EC), a versatile contaminant removal process, and ion concentration polarization (ICP) desalination, which is an electromembrane desalination process. We demonstrated a continuous EC-ICP operation that removed >95% of suspended solids and reduced the salinity from brackish range (20 mM NaCl) to a potable level (<8.6 mM NaCl). We also demonstrated that our system is flexible in terms of the type and concentration of contaminants it can handle. Combining two different electrochemical processes into a single system, we can reduce unnecessary voltage drop by having a shared anode, and achieve both seamless integration and energy efficient operation. Our system will find applications as a small-scale water treatment system, if properly scaled up in the future.

Progress on the ITER H&CD EC upper launcher steering-mirror control system

NARCIS (Netherlands)

Collazos, A.; Bertizzolo, R.; Chavan, R.; Dolizy, F.; Felici, F.; Goodman, T.P.; Henderson, M.A.; Landis, J.-D.; Sanchez, F.

2010-01-01

The ITER Heating and Current Drive Upper Launcher (H&CD EC UL) uses a pneumomechanical steering-mirror assembly (SMA) to steer the RF beams for their deposition in the appropriate location in the plasma to control magnetohydrodynamic activity (neoclassical tearing modes (NTMs) and sawtooth

Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans.

Science.gov (United States)

Vassilakos, George; Philippou, Anastassios; Koutsilieris, Michael

2017-02-01

Insulin-like growth factor-1 (IGF-1) is a pleiotropic factor expressed in various tissues and plays a critical role in skeletal muscle physiology. Alternative splicing of the IGF-1 gene gives rise to different precursor polypeptides (isoforms) which could undergo post-translational cleavage, generating the common mature IGF-1 peptide and different carboxyl terminal extension (E-) peptides, with the fate of the latter being, so far, unknown. The objective if this study was to identify the IGF-1Ec forms or processing product(s), other than mature IGF-1, generated in different human and rodent tissues and particularly in human skeletal muscle after exercise-induced damage. Protein lysates from a wide range of human and rodent tissues were immunoblotted with a rabbit anti-human Ec polyclonal antibody raised against the last 24 amino acids of the C-terminal of the Ec peptide. This antibody can recognize the Ec peptide, both as part of IGF-1Ec and alone, and also the corresponding rodent forms, due to the high homology that the human Ec shares with the rodent Eb. We were able to confirm, for the first time, that the human Ec peptide and its rodent homologous Eb peptide are produced simultaneously with their precursor protein (pro-IGF-1Ec/Eb) in vivo, in a wide range of tissues (e.g. muscle, liver, heart). Proprotein convertase furin digestion of human muscle and liver protein lysates confirmed that the higher molecular form, pro-IGF-1Ec, can be cleaved to produce the free Ec peptide. Furthermore, initial evidence is provided that Ec peptide is differentially regulated during the process of muscle regeneration after exercise-induced damage in humans. The findings of this study possibly imply that the post-translational modification of the IGF-1Ec pro-peptide may regulate the bioavailability and activity of the processing product(s). Copyright © 2016. Published by Elsevier Ltd.

Explosion-proof actuators according to EU directive 94/9/EC (ATEX)

Energy Technology Data Exchange (ETDEWEB)

Herbstritt, M. [AUMA Riester GmbH und Co. KG. Muellheim (Germany)

2004-07-01

Since July, 1, 2003 only explosion-proof devices which conform to the new EU Directive 94/9/EC, better known as the ATEX Directive, are introduced to the market. Especially the explosion protection of non-electrical equipment is a completely new task for many manufacturers. AUMA has qualified its electric actuators for the automation of industrial valves in accordance with the new regulations. In addition the design has been improved. (orig.)

A predictive model for e-commerce consumer expenditure in EC countries

OpenAIRE

Kovačić, Zlatko

2004-01-01

Describing and predicting consumer expenditure on a country or cross-national level has a long tradition in theoretical and applied economics and econometrics. This paper is a first attempt in describing aggregate eCommerce consumer expenditure among European Commission (EC) countries. After brief introduction of possible theoretical models which explain the variation in eCommerce consumer expenditure among observed countries, a list of important predictors has been discussed. The results gen...

Rethinking Modal Gender in the Context of the Universe of Tn-Types: Definitions and Mathematical Models for Tonicity and Phonicity

Directory of Open Access Journals (Sweden)

Marcus Alessi Bittencourt

2016-07-01

Full Text Available An indisputable cornerstone of the Western music tradition, the dialectic opposition between the major and minor grammatical modal genders has always been present in the imagination of musicians and music theorists for centuries. Such dialectics of opposition is especially important in the context of nineteenth-century harmonic dualism, with its ideas of tonicity and phonicity. These concepts serve as the main foundation for the way harmonic dualism conceives the major and minor worlds: two worlds with equivalent rights and properties, but with opposed polarities. This paper presents a redefinition of the terms tonicity and phonicity, translating those concepts to the context of post-tonal music theory. The terminologies of generatrix, tonicity, root, phonicity, vertex, and azimuth are explained in this paper, followed by propositions of mathematical models for those concepts, which spring from Richard Parncutt’s root-salience model for pitch-class sets. In order to demonstrate the possibilities of using modal gender as a criterion for the study and classification of the universe of Tn-types, we will present a taxonomy of the 351 transpositional set types, which comprises the categories of tonic (major, phonic (minor and neutral (genderless. In addition, there will be a small discussion on the effect of set symmetries and set asymmetries on the tonic/phonic properties of a Tn-type.

Balancing economic freedom against social policy principles: EC competition law and national health systems.

Science.gov (United States)

Mossialos, Elias; Lear, Julia

2012-07-01

EU Health policy exemplifies the philosophical tension between EC economic freedoms and social policy. EC competition law, like other internal market rules, could restrict national health policy options despite the subsidiarity principle. In particular, European health system reforms that incorporate elements of market competition may trigger the application of competition rules if non-economic gains in consumer welfare are not adequately accounted for. This article defines the policy and legal parameters of the debate between competition law and health policy. Using a sample of cases it analyses how the ECJ, national courts, and National Competition Authorities have applied competition laws to the health services sector in different circumstances and in different ways. It concludes by considering the implications of the convergence of recent trends in competition law enforcement and health system market reforms. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Shielding calculations with SCALE/MAVRIC and comparison with measurements for the TN85 cask with vitrified high level radioactive waste

Science.gov (United States)

Thiele, Holger; Börst, Frank-Michael

2017-09-01

A series of dose rate/spectra measurements in the German interim storage facility Gorleben was carried out at a TN85 cask in April 2009. This type of cask is used for the transport and interim storage of vitrified high level radioactive waste (HAW) from reprocessing. The aim of this work is to assess the shielding component MAVRIC of the SCALE code system with these measurements for the use in the German Bundesamt für Kerntechnische Entsorgungssicherheit (BfE).

Regulation (EC No 1901/2006 on medicinal products for paediatric use & clinical research in vulnerable populations

Directory of Open Access Journals (Sweden)

Lehmann Birka

2008-12-01

Full Text Available Abstract Before any medicinal product is authorised for use in adults, it must undergo extensive pharmaceutical consistency and stability tests, toxicological tests and clinical trials to ensure that it is of high quality, safe and effective. The same approach may not always be applied to medicinal products used to treat children. Studies showed that over 50% of the medicinal products used in children may not have been tested for use in this age group. The absence of suitable authorised medicinal products to treat conditions in children results from the fact that pharmaceutical companies do not adapt medicinal products to the needs of the paediatric population. This leaves health care professionals with no alternative other than to use medicinal products "off-label" and to use unauthorised products with the associated risks of inefficacy and/or adverse reactions. The Regulation (EC No 1901/2006 sets up a system of requirements, rewards and incentives, together with horizontal measures, to ensure that medicinal products are researched, developed and authorised to meet the therapeutic needs of children. The Regulation is addressed to: 1. The pharmaceutical industry by setting out the legal framework for receiving rewards and incentives by conducting clinical trials in the paediatric population. 2. The Member States to set out to support research into, and the development and availability of, medicinal products for paediatric use. 3. The Community as funds for research into medicinal products for the paediatric population shall be provided for in the Community budget in order to support studies relating to medicinal products or active substances not covered by a patent or a supplementary protection certificate. The legal framework for conducting clinical trials, including children/minors, is set up in Directive 2001/20/EC, the Clinical Trials Directive (CTD, for the European Union (EU. The CTD establishes specific provisions regarding conduct of

Integrating Amazon EC2 with the CMS Production Framework

CERN Document Server

Melo, Andrew Malone

2011-01-01

As cloud middleware and cloud providers have become more robust, various experiments with experience in Grid submission have begun to investigate the possibility of taking previously Grid-Enabled applications and making them compatible with Cloud Computing. Successful implementation will allow for dynamic scaling of the available hardware resources, providing access to peak-load handling capabilities and possibly resulting in lower costs to the experiment. Here we discuss current work within the CMS collaboration at the LHC to both perform computation on EC2, both for production and analysis use-cases. We also discuss break-even points between dedicated and cloud resources using real-world costs derived from a CMS site.

Integrating Amazon EC2 with the CMS production framework

International Nuclear Information System (INIS)

Melo, Andrew; Sheldon, Paul

2012-01-01

As cloud middleware and cloud providers have become more robust, various experiments with experience in Grid submission have begun to investigate the possibility of taking previously Grid-Enabled applications and making them compatible with Cloud Computing. Successful implementation will allow for dynamic scaling of the available hardware resources, providing access to peak-load handling capabilities and possibly resulting in lower costs to the experiment. Here we discuss current work within the CMS collaboration at the LHC to both perform computation on EC2, both for production and analysis use-cases. We also discuss break-even points between dedicated and cloud resources using real-world costs derived from a CMS site.

Assessment of regeneration of bone in the extracted third molar sockets augmented using xenograft (CollaPlugTN Zimmer in comparison with the normal healing on the contralateral side

Directory of Open Access Journals (Sweden)

Murugan Ranganathan

2017-01-01

Full Text Available Introduction: Alveolar bone resorption is a significant clinical problem. Bone loss in third molar region following extraction or surgical removal not only leads to periodontal problems in second molar region but also it may lead to some serious problems like increased incidence of angle fractures. In order to reduce the risks following third molar surgery, the socket should be augmented with bone grafts. In recent days guided tissue regeneration is the most accepted and successful technique followed many authors and its efficacy has been proved. Materials and Methods: Based upon our clinical experience, the use of bio absorbable collagen wound dressing such as CollaPlugTN has achieved quick healing and more primary wound coverage. Amongst the graft materials collagen is preferable due to its high biocompatibility and hemostatic ability. This study was done to assess the regeneration of bone in the extracted third molar sockets using xenograft (CollaPlugTN-Zimmer which was compared with the normal healing on the contra lateral side. The assessment was done to analyze post-operative healing complications and to compare the bone density formed between control site and implant site radiologically. Conclusion: On this basis of this study, the use of collaplugTN appears to be beneficial to the patient in postoperative wound healing and also for better bone formation. The use of this material was advantageous because of its simplicity of application cost effectiveness and availability. There is enhanced wound healing and early bone formation.

Assessment of Regeneration of Bone in the Extracted Third Molar Sockets Augmented Using Xenograft (CollaPlugTN Zimmer) in Comparison with the Normal Healing on the Contralateral Side.

Science.gov (United States)

Ranganathan, Murugan; Balaji, M; Krishnaraj, R; Narayanan, Vivek; Thangavelu, Annamalai

2017-11-01

Alveolar bone resorption is a significant clinical problem. Bone loss in third molar region following extraction or surgical removal not only leads to periodontal problems in second molar region but also it may lead to some serious problems like increased incidence of angle fractures. In order to reduce the risks following third molar surgery, the socket should be augmented with bone grafts. In recent days guided tissue regeneration is the most accepted and successful technique followed many authors and its efficacy has been proved. Based upon our clinical experience, the use of bio absorbable collagen wound dressing such as CollaPlug TN has achieved quick healing and more primary wound coverage. Amongst the graft materials collagen is preferable due to its high biocompatibility and hemostatic ability. This study was done to assess the regeneration of bone in the extracted third molar sockets using xenograft (CollaPlug TN -Zimmer) which was compared with the normal healing on the contra lateral side. The assessment was done to analyze post-operative healing complications and to compare the bone density formed between control site and implant site radiologically. On this basis of this study, the use of collaplugTN appears to be beneficial to the patient in postoperative wound healing and also for better bone formation. The use of this material was advantageous because of its simplicity of application cost effectiveness and availability. There is enhanced wound healing and early bone formation.

Disulfide-stabilized Helical Hairpin Structure and Activity of a Novel Antifungal Peptide EcAMP1 from Seeds of Barnyard Grass (Echinochloa crus-galli)*

Science.gov (United States)

Nolde, Svetlana B.; Vassilevski, Alexander A.; Rogozhin, Eugene A.; Barinov, Nikolay A.; Balashova, Tamara A.; Samsonova, Olga V.; Baranov, Yuri V.; Feofanov, Alexey V.; Egorov, Tsezi A.; Arseniev, Alexander S.; Grishin, Eugene V.

2011-01-01

This study presents purification, activity characterization, and 1H NMR study of the novel antifungal peptide EcAMP1 from kernels of barnyard grass Echinochloa crus-galli. The peptide adopts a disulfide-stabilized α-helical hairpin structure in aqueous solution and thus represents a novel fold among naturally occurring antimicrobial peptides. Micromolar concentrations of EcAMP1 were shown to inhibit growth of several fungal phytopathogens. Confocal microscopy revealed intensive EcAMP1 binding to the surface of fungal conidia followed by internalization and accumulation in the cytoplasm without disturbance of membrane integrity. Close spatial structure similarity between EcAMP1, the trypsin inhibitor VhTI from seeds of Veronica hederifolia, and some scorpion and cone snail toxins suggests natural elaboration of different functions on a common fold. PMID:21561864

Disulfide-stabilized helical hairpin structure and activity of a novel antifungal peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli).

Science.gov (United States)

Nolde, Svetlana B; Vassilevski, Alexander A; Rogozhin, Eugene A; Barinov, Nikolay A; Balashova, Tamara A; Samsonova, Olga V; Baranov, Yuri V; Feofanov, Alexey V; Egorov, Tsezi A; Arseniev, Alexander S; Grishin, Eugene V

2011-07-15

This study presents purification, activity characterization, and (1)H NMR study of the novel antifungal peptide EcAMP1 from kernels of barnyard grass Echinochloa crus-galli. The peptide adopts a disulfide-stabilized α-helical hairpin structure in aqueous solution and thus represents a novel fold among naturally occurring antimicrobial peptides. Micromolar concentrations of EcAMP1 were shown to inhibit growth of several fungal phytopathogens. Confocal microscopy revealed intensive EcAMP1 binding to the surface of fungal conidia followed by internalization and accumulation in the cytoplasm without disturbance of membrane integrity. Close spatial structure similarity between EcAMP1, the trypsin inhibitor VhTI from seeds of Veronica hederifolia, and some scorpion and cone snail toxins suggests natural elaboration of different functions on a common fold.

Changes of serum contents of LPO, SOD after treatment with vita. E-C complex in patients with liver spot

International Nuclear Information System (INIS)

Li Qing; Feng Zheng

2005-01-01

Objective: To investigate the changes of serum contents of LPO, SOD and therapeutic efficacy after treatment with Vita. E-C complex in patients with liver spot. Methods: Serum LPO and SOD contents were measured both before and after treatment with Vita E-C complex (Vita. E l00mg, Vita. C 200mg x 3/d for 3 months) in 30 patients with liver spot as well as in 10 controls. Results: Before treatment, the serum LPO contents in the patients were significantly higher than those in controls. After treatment, the LPO contents dropped markedly, being significantly lower than the values before treatment. However, the SOD contents were about the same as those in controls and changes little after treatment. Conclusion: Vita. E-C complex was of definite therapeutic value for the treatment of liver spot. (authors)

Involvement of the G-protein-coupled dopamine/ecdysteroid receptor DopEcR in the behavioral response to sex pheromone in an insect.

Directory of Open Access Journals (Sweden)

Antoine Abrieux

Full Text Available Most animals including insects rely on olfaction to find their mating partners. In moths, males are attracted by female-produced sex pheromones inducing stereotyped sexual behavior. The behaviorally relevant olfactory information is processed in the primary olfactory centre, the antennal lobe (AL. Evidence is now accumulating that modulation of sex-linked behavioral output occurs through neuronal plasticity via the action of hormones and/or catecholamines. A G-protein-coupled receptor (GPCR binding to 20-hydroxyecdysone, the main insect steroid hormone, and dopamine, has been identified in Drosophila (DmDopEcR, and was suggested to modulate neuronal signaling. In the male moth Agrotis ipsilon, the behavioral and central nervous responses to pheromone are age-dependent. To further unveil the mechanisms of this olfactory plasticity, we searched for DopEcR and tested its potential role in the behavioral response to sex pheromone in A. ipsilon males. Our results show that A. ipsilon DopEcR (named AipsDopEcR is predominantly expressed in the nervous system. The corresponding protein was detected immunohistochemically in the ALs and higher brain centers including the mushroom bodies. Moreover, AipsDopEcR expression increased with age. Using a strategy of RNA interference, we also show that silencing of AipsDopEcR inhibited the behavioral response to sex pheromone in wind tunnel experiments. Altogether our results indicate that this GPCR is involved in the expression of sexual behavior in the male moth, probably by modulating the central nervous processing of sex pheromone through the action of one or both of its ligands.

Physicochemical and toxicological profiling of ash from the 2010 and 2011 eruptions of Eyjafjallajökull and Grímsvötn volcanoes, Iceland using a rapid respiratory hazard assessment protocol.

Science.gov (United States)

Horwell, C J; Baxter, P J; Hillman, S E; Calkins, J A; Damby, D E; Delmelle, P; Donaldson, K; Dunster, C; Fubini, B; Kelly, F J; Le Blond, J S; Livi, K J T; Murphy, F; Nattrass, C; Sweeney, S; Tetley, T D; Thordarson, T; Tomatis, M

2013-11-01

The six week eruption of Eyjafjallajökull volcano in 2010 produced heavy ash fall in a sparsely populated area of southern and south eastern Iceland and disrupted European commercial flights for at least 6 days. We adopted a protocol for the rapid analysis of volcanic ash particles, for the purpose of informing respiratory health risk assessments. Ash collected from deposits underwent a multi-laboratory physicochemical and toxicological investigation of their mineralogical parameters associated with bio-reactivity, and selected in vitro toxicology assays related to pulmonary inflammatory responses. Ash from the eruption of Grímsvötn, Iceland, in 2011 was also studied. The results were benchmarked against ash from Soufrière Hills volcano, Montserrat, which has been extensively studied since the onset of eruptive activity in 1995. For Eyjafjallajökull, the grain size distributions were variable: 2-13 vol% of the bulk samples were <4 µm, with the most explosive phases of the eruption generating abundant respirable particulate matter. In contrast, the Grímsvötn ash was almost uniformly coarse (<3.5 vol%<4 µm material). Surface area ranged from 0.3 to 7.7 m2 g(-1) for Eyjafjallajökull but was very low for Grímsvötn (<0.6 m2 g(-1)). There were few fibre-like particles (which were unrelated to asbestos) and the crystalline silica content was negligible in both eruptions, whereas Soufrière Hills ash was cristobalite-rich with a known potential to cause silicosis. All samples displayed a low ability to deplete lung antioxidant defences, showed little haemolysis and low acute cytotoxicity in human alveolar type-1 like epithelial cells (TT1). However, cell-free tests showed substantial hydroxyl radical generation in the presence of hydrogen peroxide for Grímsvötn samples, as expected for basaltic, Fe-rich ash. Cellular mediators MCP-1, IL-6, and IL-8 showed chronic pro-inflammatory responses in Eyjafjallajökull, Grímsvötn and Soufrière Hills samples

Statement of Roy F. Pruett, Mayor, City of Oak Ridge, TN

International Nuclear Information System (INIS)

Anon.

1987-01-01

Thank you very much, Mr. Chairman, and Members of the Committee. My name is Roy Pruett, mayor of the city of Oak Ridge, TN, and an executive committee member on the Clinch River MRS task force. It is my pleasure to be here today to testify before this distinguished Committee and present the findings of the Clinch River task force as they relate to subtitle C of the Nuclear Waste Policy Act of 1982, and to the Department of Energy proposal on the Monitored Retrievable Storage facility, the MRS. I represent the city of Oak Ridge, which has been selected for the primary and the first alternative for the siting of an integrated MRS facility for the preparation and packaging of high-level nuclear waste and spent reactor fuel. Of civic and governmental leaders, we concluded that an MRS could safely be built and operated in Oak Ridge. We further concluded, however, that the facility would not be generally perceived as being safe unless the recommendations of the task force were adopted to address concerns and help mitigate impact. Indeed the MRS would not be viewed as a net economic benefit to the site's community, the region, or the State of Tennessee without such appropriate conditions

Electronic Payments and Consumer Protection : Should Recommendation 97/489/EC Be Replaced with a Directive?

NARCIS (Netherlands)

Schudelaro, A.A.P.

2001-01-01

This article examines the question whether the EC Regulation concerning transactions carried out by electronic payment instruments should be replaced by a Directive that is binding on all member states of the EU.

High-Level Heat Resistance of Spores of Bacillus amyloliquefaciens and Bacillus licheniformis Results from the Presence of a spoVA Operon in a Tn1546 Transposon

NARCIS (Netherlands)

Berendsen, Erwin M; Koning, Rosella A; Boekhorst, Jos; de Jong, Anne; Kuipers, Oscar P; Wells-Bennik, Marjon H J

2016-01-01

Bacterial endospore formers can produce spores that are resistant to many food processing conditions, including heat. Some spores may survive heating processes aimed at production of commercially sterile foods. Recently, it was shown that a spoVA operon, designated spoVA(2mob), present on a Tn1546

Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.24.11 which are highly resistant to serine- and metalloproteases

Directory of Open Access Journals (Sweden)

M.A.S. Medeiros

1997-10-01

Full Text Available Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz and ethylenediamine 2,4-dinitrophenyl (EDDnp groups at amino- and carboxyl-terminal amino acid residues, Abz-DArg-Arg-Leu-EDDnp (Abz-DRRL-EDDnp and Abz-DArg-Arg-Phe-EDDnp (Abz-DRRF-EDDnp, were selectively hydrolyzed by neutral endopeptidase (NEP, enkephalinase, neprilysin, EC 3.4.24.11 at the Arg-Leu and Arg-Phe bonds, respectively. The kinetic parameters for the NEP-catalyzed hydrolysis of Abz-DRRL-EDDnp and Abz-DRRF-EDDnp were Km = 2.8 µM, kcat = 5.3 min-1, kcat/Km = 2 min-1 µM-1 and Km = 5.0 µM, kcat = 7.0 min-1, kcat/Km = 1.4 min-1 µM-1, respectively. The high specificity of these substrates was demonstrated by their resistance to hydrolysis by metalloproteases [thermolysin (EC 3.4.24.2, angiotensin-converting enzyme (ACE; EC 3.4.24.15], serineproteases [trypsin (EC 3.4.21.4, a-chymotrypsin (EC 3.4.21.1] and proteases present in tissue homogenates from kidney, lung, brain and testis. The blocked amino- and carboxyl-terminal amino acids protected these substrates against the action of aminopeptidases, carboxypeptidases and ACE. Furthermore, DR amino acids ensured total protection of Abz-DRRL-EDDnp and Abz-DRRF-EDDnp against the action of thermolysin and trypsin. Leu-EDDnp and Phe-EDDnp were resistant to hydrolysis by a-chymotrypsin. The high specifity of these substrates suggests their use for specific NEP assays in crude enzyme preparations

Georeferenced measurement of soil EC as a tool to detect susceptible areas to water erosion.

Science.gov (United States)

Fabian Sallesses, Leonardo; Aparicio, Virginia Carolina; Costa, Jose Luis

2017-04-01

The Southeast region of Buenos Aires Province, Argentina, is one of the main region for the cultivation of potato (Solanum tuberosum L.) in that country. The implementation of complementary irrigation for potato cultivation meant an increase in yield of up to 60%. Therefore, all potato production in the region is under irrigation. In this way, the area under central pivot irrigation has increased to 150% in the last two decades. The water used for irrigation in that region is underground with a high concentration of sodium bicarbonate. The combination of irrigation and rain increases the sodium absorption ratio of soil (SARs), consequently raising the clay dispersion and reducing infiltration. A reduction in infiltration means greater partitioning of precipitation into runoff. The degree of slope of the terrain, added to its length, increases the erosive potential of runoff water. The content of dissolved salts, in combination with the water content, affect the apparent Electrical Conductivity of the soil (EC), which is directly related to the concentration of Na + 2 in the soil solution. In August 2016, severe rill erosion was detected in a productive plot of 300 ha. The predecessor crop was a potato under irrigation campaign. However the history of the lot consists of various winter and summer crops, always made in dry land and no till. Cumulative rainfall from harvest to erosion detection (four months) was 250 mm. A georeferenced EC measurement was performed using the Verys 3100® contact sensor. With the data obtained, a geostatistical analysis was performed using Kriging spatial interpolation. The maps obtained were processed, dividing them into 4 EC ranges. The values and amplitude of the CEa ranges for each lot were determined according to the distribution observed in the generated histograms. It was observed a distribution of elevated EC ranges and consequently of a higher concentration of Na+ 2 coincident with the irrigation areas of the pivots. These

Practices and rules applied for the design of large dry PWR-containments within EC countries

International Nuclear Information System (INIS)

Karwat, H.

1989-01-01

The containment system is an essential component of nuclear power plants and its behaviour plays an important role in the evaluation of accident consequences of pressurized water reactors. The present report illuminates the analytical methods for the simulation of the thermohydraulic loads and the experimental background to support these methods. The national rules and practices applied within the EC member countries to determine the local and global design loads were compared. For thermohydraulic load prediction only small differences have been found, particularly in the required safety addition factors covering the uncertainties of the predictive analytical simulation procedures. Comparison of design loads shows in general that analytical methods are comparable throughout the EC member countries and, with regard to their determination, warrant to a large extent an equal degree of conservatism

User illusion: ideological construction of ‘user-generated content’ in the EC consultation on copyright

Directory of Open Access Journals (Sweden)

Kristofer Erickson

2014-10-01

Full Text Available Recent policy consultations by the UK Intellectual Property Office, the US Patent and Trademark Office and the European Commission (EC have highlighted the importance of user-generated content in debates to reform copyright. User-generated content (UGC – often combining existing copyright material with transformative creativity – remains a contested terrain, with no clear or widely accepted definition. This paper examines how various stakeholders in the 2014 EC consultation on copyright attempted to shape the definition of UGC in order to suit their interests, sometimes aligning or conflicting with other stakeholder groups. Data from 203 written responses by registered stakeholders (authors, platform intermediaries and users were subjected to a discourse analysis methodology. Key arguments and policy preferences from each stakeholder group are identified and discussed.

Study of Synergetic Effect of X2 and X3 EC Wave in KSTAR

Directory of Open Access Journals (Sweden)

Bae Y.S.

2015-01-01

Full Text Available An experimental study of the X-mode absorption at the second and the third harmonic frequencies has been performed in KSTAR tokamak. The X2 EC frequency is 110 GHz and the X3 EC frequency is 170 GHz at the nominal KSTAR operating toroidal magnetic field. From the 1-D model of the synergetic effect, the X3 cold resonance should lie at low field side with the X2 cold resonance at the high field side to meet the condition which both X2 and X3 EC waves interact with the same resonant electron at the same radial position. However, 170 GHz X3 cold resonance lies at the high field side with distance of 54 mm from the X2 cold resonance position in KSTAR. This paper presents the study of the synergetic effect of X3 absorption by the X2 ECCD with a scheme of two beam target positions at the same flux surface by scanning the poloidal and toroidal beam injection angles to enhance X3 absorption even in the low temperature plasma in KSTAR. For this study, the3D relativistic ray/tracing and Fokker-Planck codes C3PO/LUKE is used for the quantitative prediction of its synergetic effect. The C3PO/LUKE codes are appropriate for X2 and X3 synergy calculations as the distribution function can be calculated with either one or both waves affecting the absorption rate of each other. This paper also introduces the future ECH system upgrade plan.

Assessing the Influence of Seasonal and Spatial Variations on the Estimation of Secondary Organic Carbon in Urban Particulate Matter by Applying the EC-Tracer Method

Directory of Open Access Journals (Sweden)

Sandra Wagener

2014-04-01

Full Text Available The elemental carbon (EC-tracer method was applied to PM10 and PM1 data of three sampling sites in the City of Berlin from February to October 2010. The sites were characterized by differing exposure to traffic and vegetation. The aim was to determine the secondary organic carbon (SOC concentration and to describe the parameters influencing the application of the EC-tracer method. The evaluation was based on comparisons with results obtained from positive matrix factorization (PMF applied to the same samples. To obtain site- and seasonal representative primary OC/EC-ratios ([OC/EC]p, the EC-tracer method was performed separately for each station, and additionally discrete for samples with high and low contribution of biomass burning. Estimated SOC-concentrations for all stations were between 11% and 33% of total OC. SOC-concentrations obtained with PMF exceeded EC-tracer results more than 100% at the park in the period with low biomass burning emissions in PM10. The deviations were besides others attributed to the high ratio of biogenic to combustion emissions and to direct exposure to vegetation. The occurrences of biomass burning emissions in contrast lead to increased SOC-concentrations compared to PMF in PM10. The obtained results distinguish that the EC-tracer-method provides well comparable results with PMF if sites are strongly influenced by one characteristic primary combustion source, but was found to be adversely influenced by direct and relatively high biogenic emissions.

Factors influencing arsenic and nitrate removal from drinking water in a continuous flow electrocoagulation (EC) process

International Nuclear Information System (INIS)

Kumar, N. Sanjeev; Goel, Sudha

2010-01-01

An experimental study was conducted under continuous flow conditions to evaluate some of the factors influencing contaminant removal by electrocoagulation (EC). A bench-scale simulation of drinking water treatment was done by adding a filtration column after a rectangular EC reactor. Contaminant removal efficiency was determined for voltages ranging from 10 to 25 V and a comparative study was done with distilled water and tap water for two contaminants: nitrate and arsenic(V). Maximum removal efficiency was 84% for nitrate at 25 V and 75% for arsenic(V) at 20 V. No significant difference in contaminant removal was observed in tap water versus distilled water. Increase in initial As(V) concentration from 1 ppm to 2 ppm resulted in a 10% increase in removal efficiency. Turbidity in the EC reactor effluent was 52 NTU and had to be filtered to achieve acceptable levels of final turbidity (5 NTU) at steady-state. The flow regime in the continuous flow reactor was also evaluated in a tracer study to determine whether it is a plug flow reactor (PFR) or constantly stirred tank reactor (CSTR) and the results show that this reactor was close to an ideal CSTR, i.e., it was fairly well-mixed.

Factors influencing arsenic and nitrate removal from drinking water in a continuous flow electrocoagulation (EC) process

Energy Technology Data Exchange (ETDEWEB)

Kumar, N. Sanjeev [Civil Engineering Department, IIT Kharagpur, Kharagpur 721302 (India); Goel, Sudha, E-mail: sudhagoel@civil.iitkgp.ernet.in [Civil Engineering Department, IIT Kharagpur, Kharagpur 721302 (India)

2010-01-15

An experimental study was conducted under continuous flow conditions to evaluate some of the factors influencing contaminant removal by electrocoagulation (EC). A bench-scale simulation of drinking water treatment was done by adding a filtration column after a rectangular EC reactor. Contaminant removal efficiency was determined for voltages ranging from 10 to 25 V and a comparative study was done with distilled water and tap water for two contaminants: nitrate and arsenic(V). Maximum removal efficiency was 84% for nitrate at 25 V and 75% for arsenic(V) at 20 V. No significant difference in contaminant removal was observed in tap water versus distilled water. Increase in initial As(V) concentration from 1 ppm to 2 ppm resulted in a 10% increase in removal efficiency. Turbidity in the EC reactor effluent was 52 NTU and had to be filtered to achieve acceptable levels of final turbidity (5 NTU) at steady-state. The flow regime in the continuous flow reactor was also evaluated in a tracer study to determine whether it is a plug flow reactor (PFR) or constantly stirred tank reactor (CSTR) and the results show that this reactor was close to an ideal CSTR, i.e., it was fairly well-mixed.

Current status of ITER EC design

International Nuclear Information System (INIS)

Bosia, G.

2003-01-01

The ITER-FEAT Electron Cyclotron System employs one equatorial launcher and three upper port launchers to inject 20 + 20 MW of mm-wave power at 170 GHz through slots in the plasma-facing neutron and radiation shield. The equatorial launcher includes 3 sets of toroidally steer-able mirrors, each collecting 8 RF beams from 24 circular cross-section corrugated wave-guides. In the upper-port launcher, eight beams, reflected in pairs by four toroidally angled (∼30 angle) and poloidally steer-able (∼ 10 angle) mirrors focus of the RF power on the plasma m = 2 and m = 3/2 plasma flux rational surfaces, for neo-classical tearing mode(s) (NTM) control. Conceptual studies of remote steering that would possibly allow removing the beam- steering equipment from the vacuum vessel and locating them in more protected positions have been carried out. All EC wave transmission is based on low losses circular cross section corrugated and evacuated wave guides each connected to a 170 GHz, 1 MW CW Gyrotron tube oscillator featuring an overall efficiency of ∼ 50%, obtained by depressed-collector energy recovery. In the paper, requirements, issues and the current status of the design is reviewed. (authors)

Ionothermal synthesis of discrete supertetrahedral Tn (n = 4, 5) clusters with tunable components, band gaps, and fluorescence properties.

Science.gov (United States)

Yang, Dan-Dan; Li, Wei; Xiong, Wei-Wei; Li, Jian-Rong; Huang, Xiao-Ying

2018-05-01

The preparation of crystalline molecularly supertetrahedral Tn clusters with variable sizes and components is of vital importance for the fundamental study of their physicochemical properties. However, setting up an efficient method to stabilize large discrete Tn clusters is a challenge due to their high negative charges and polymerization nature. In this work, we report on the ionothermal synthesis of three discrete T4 cluster compounds, namely [Bmmim]5[(CH3)2NH2]4[NH4][M4In16S31(SH)4]·6H2O (M = Mn (1), Zn (2), Cd (3), Bmmim = 1-buty-2,3-dimethyl-imidazolium), and four discrete T5 cluster compounds, namely [Bmmim]10[NH4]3[Cu5Ga30-xInxS52(SH)4] (x = 6.6 (5), 14.5 (6), 23.8 (7), and 30 (8)). The compound [Bmmim]10[NH4]3[Cu5Ga30S52(SH)4] (4) previously reported by us features a discrete T5 cluster. The steep UV-Vis absorption edges indicate band gaps of 2.20 eV for 1, 2.64 eV for 2, 2.69 eV for 3, 3.04 eV for 4, 2.65 eV for 5, 2.48 eV for 6, 2.32 eV for 7, and 2.30 eV for 8. The compositions of T5 clusters could be varied with the ratios of Ga : In in the starting reagents, providing an opportunity to systematically control the band gaps and fluorescence performances of T5 cluster-based compounds. This research might advance the understanding of the ionothermal preparation and functionality tuning of crystalline chalcogenides.

Electrocoagulation (EC and Electrocoagulation/Flotation(ECF Processes for Removing High Turbidity from Surface Water Using Al and Fe Electrodes

Directory of Open Access Journals (Sweden)

Ghorban Asgari

2013-08-01

Full Text Available Electrocoagulation (EC and Electrocoagulation/flotation (ECF processes are simple and efficient in water and wastewater treatment. In recent years, many investigations have focused on the use of these processes for treating of polluted water. The purpose of this study was to investigate the efficiency of EC and ECF processes in removal of high turbidity water using different electrodes in different circumstances. In present study an electrocoagulation and electrocoagulation/ flotation reactor in a lab scale to an approximate volume of 6 liters which is equipped with four Al-AL and Fe-Fe electrodes (200 * 20 * 2 mm was used  for removing of high turbidity water. The effects of operating parameters such as type of electrodes, initial water turbidity, applied voltage (10 to 30 v, initial pH of the solution (3 to 12 and reaction times (5 to 30 minutes were evaluated. The batch experimental results showed that initial turbidity water, initial pH of the solution, different applied voltages up to %88 turbidity as initial turbidity of 1200 NTU have been removed when using Al-Al and Fe-Fe electrodes and reaction times highly effective on the turbidity removal efficiency in these processes. In ECF process, 84% in optimum condition. However, in EC  process the maximum removal was found  up to 68% of initial turbidity when using Al-Al and Fe-Fe electrodes in same operation. Based on the result obtained in this study, the type of electrodes in EC and ECF processes  significantly affect the removal rate of high turbid water. Also, it was found that much higher turbidity removal could be achieved by ECF process than that by EC process in the same condition.

Statement of Kenneth E. Yager, County Executive, Roane County, TN

International Nuclear Information System (INIS)

Anon.

1987-01-01

I am Ken Yager, I am the county executive for Roane County, TN which is the preferred site for the proposed Monitored Retrieval Storage facility, or the MRS. and I am submitting into the record additional written testimony which was written largely by the Honorable Robert Peele, who is sitting here, who is a member of the Roane County Board of Commissioners, our local legislative body. The premise of my remarks is that the Department of Energy proposal for the MRS in our county in unacceptable unless the Congress and the Department of Energy are to be willing partners with the local communities. Our considerations have been limited to: one, can an MRS be operated safely, and if so under what conditions; and what would be the impacts of the facility and how might they be mitigated. Our recommendations on those two points lead me to my earlier comment about being partners with the Congress, because our recommendations can be summed up simply, Mr. Chairman, as local control. We are exceedingly concerned about the prospect of being trapped in a national squeeze play, caught between a recognized need for a way to deal with nuclear waste and intense political efforts to put that problem in somebody else's back yard. And if we are to be that back yard, we would ask that the Congress and the Department of Energy recognize our stake in this national effort. We must have an equal role in the process

Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: the follow-up study of gastrointestinal cancer patients.

Science.gov (United States)

Smorodin, Eugeniy-P; Kurtenkov, Oleg-A; Sergeyev, Boris-L; Kodar, Kristel-E; Chuzmarov, Valentin-I; Afanasyev, Vladimir-P

2008-07-21

To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic alphaGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages I-IV without distant metastases were subjected to follow-up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P gastric cancer patients (sign test, 20 vs 8, P cancer, the elevated postoperative level of TF, Tn and alphaGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages III-IV (c2 = 4.71, gastric cancer; c2 = 4.11, gastrointestinal cancer; P stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens.

Tn5-induced pBS286 plasmid mutations blocking early stages of napthalene oxidation

International Nuclear Information System (INIS)

Kosheleva, I.A.; Tsoi, T.V.; Ivashina, T.V.; Selifonov, S.A.; Starovoitov, I.I.; Boronin, A.M.

1988-01-01

The authors present data on the further analysis of the structural and functional organization of the nah region of plasmid pBS286 controlling the constitutive oxidation of naphthalene by Pseudomonas putida cells. They have studied Tn5-induced mutations blocking early stages of naphthalene oxidation. They present and discuss data providing evidence that, in contrast to plasmid NAH7, the mechanism of regulation of the nahl operon of plasmid NPL-1, the parent plasmid of plasmid pBS286, with inducible synthesis of naphthalene dioxygenase can include elements of a negative control with participation of the regulatory locus R, located proximal to the structural nah genes and closely linked to or overlapped by the inverted control DNA segment (4.2 kb). They also present data on the possibility of regulation of the activity of the catechol-splitting meta-pathway genes with the participation of products of early stages of naphthalene oxidation

Safety of hydroxytyrosol as a novel food pursuant to Regulation (EC) No 258/97

DEFF Research Database (Denmark)

Sjödin, Anders Mikael

2017-01-01

Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on hydroxytyrosol, which is chemically synthesised, as a novel food (NF) pursuant to Regulation (EC) No 258/97. The information provided on the comp......Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on hydroxytyrosol, which is chemically synthesised, as a novel food (NF) pursuant to Regulation (EC) No 258/97. The information provided...... of hydroxytyrosol from the consumption of olive oils and olives, which has not been associated with adverse effects, and considering the similar kinetics of hydroxytyrosol in rats and humans, the Panel considers that the MoE for the NF at the intended uses and use levels is sufficient for the target population....... The Panel concludes that the novel food, hydroxytyrosol, is safe under the proposed uses and use levels....

Effects of Organic Load, pH, and EC Variations of Raw Wastewater and Weather Condition on the Efficiency of Yazd Stabilization Ponds

Directory of Open Access Journals (Sweden)

Seyed Alireza Mozaheb

2009-06-01

Full Text Available This study investigates the effects of organic load, pH, and EC variations of raw wastewater as well as the effect of weather condition on organic removal in Yazd wastewater Stabilization Ponds (2007. During the course of this study, composite samples were collected from the inlet and outlet of the anaerobic pond and the final effluent to measure such quality parameters as BOD5, COD, TSS, EC, and pH.  BOD5, COD, TSS, and Fecal coliform removal efficiencies in the final effluent were found to be 64.9%, 44.9 %, 62.6 %, and 99.96%, respectively. No intestinal nematode egg was observed. Comparison of BOD5 and COD concentrations in the filtered and non-filtered samples showed that 52% of the BOD5 and 57% of the COD in the final effluent, respectively, were due to the presence of algal mass and organic suspended solids in the non-filtered samples. The results showed that variations in organic load, pH, EC as well as seasonal weather variations had no effects on organic removal and that the removal of BOD5 was almost constant. Effluent EC was higher than influent EC. This phenomenon can be related to the evaporation rate in wastewater stabilization ponds. The survey of algae in the final effluent showed that the major species of algae were Phytoconis, Chlorella, and Anabaena.

Nuclear Structure of 124Xe Studied with β+/EC-Decay

Science.gov (United States)

Radich, A. J.; Garrett, P. E.; Allmond, J. M.; Andreoiu, C.; Ball, G. C.; Bianco, L.; Bildstein, V.; Chagnon-Lessard, S.; Cross, D. S.; Diaz Varela, A.; Dunlop, R.; Finlay, P.; Garnsworthy, A. B.; Hackman, G.; Hadinia, B.; Jigmeddorj, B.; Laffoley, A. T.; Leach, K. G.; Michetti-Wilson, J.; Orce, J. N.; Rajabali, M. M.; Rand, E.; Starosta, K.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wang, Z. M.; Wood, J. L.; Wong, J.; Williams, S. J.; Yates, S. W.

The nuclear structure of 124Xe was investigated using γ-ray spectroscopy following the β+/EC-decay of 124Cs. A very high-statistics data set was collected and γγ coincidence data was analyzed, greatly adding to the 124Xe level scheme. A new decay branch from the high-spin isomer of 124Cs was observed as well as weak E2 transitions into excited 0+ states in 124Xe. B(E2) transition strengths of such low-spin transitions are very important in determining collective properties, which are currently poorly characterized in the region of neutron-deficient xenon isotopes.

Grain Refinement of Commercial EC Grade 1070 Aluminium Alloy for Electrical Application

OpenAIRE

Hassanabadi, Massoud

2015-01-01

The aluminium alloys for electrical conductivity applications are generally not grain refinedsince the addition of grain refiners drops the electrical conductivity by introducing impuritiesinto the melt. Non-grain refined aluminium may lead to bar fracture and cracks during themetalworking process. The present study focuses to find an optimum balance between the grain refiner addition andthe electrical conductivity of commercial EC grade 1070 aluminium alloy for electricalapplication. In orde...

Special report: EC oil market

International Nuclear Information System (INIS)

Anon.

1992-01-01

A European Commission report on the EC's oil market has conceded that the Community will not meet its official objective of reducing oil's share of energy consumption to 40% by 1995. The paper, a 'Communication' to the European Council entitled ''The Oil Market and the Refining Industry in the Community: Recent Developments and Prospects'' says oil will ''continue to account for a major share - of the order of 45% -of the Community's energy consumption'' up to the year 2000. Nonetheless, the report's authors insist the Commission has proposed ''a number of measures'' which could reduce the potential consumption of fossil fuels and help limit CO2 emissions. The report confirms that though lower in 1990 than 1980 at 530mt, oil demand picked up in the second half of the 1980s, reflecting world trends. Little impression has been made on the proportion of the Community's crude supply that is imported. However, one area where the report did find energy objectives successes was that of diversifying sources of crude oil supply. A major source of concern for the Commission at one stage in the second half of the 1980s was the possibility of massive imports of finished oil products from refineries in the oil producing countries. However, the fact that this threat did not materialise is taken as a vindication of the Commission's assessment in previous analyses that ''an open Community market should be maintained''. (author)

Europol’s Cybercrime Centre (EC3), its Agreements with Third Parties and the Growing Role of Law Enforcement on the European Security Scene

DEFF Research Database (Denmark)

Vendius, Trine Thygesen

2015-01-01

The European Cyber Crime Centre, EC3, established under the umbrella of Europol, started operations on January 1 2013. It is to act as the focal point in the fight against cybercrime in the European Union. Using a “shared, cross-community approach” the EC3 is concluding partnerships with member...... states, European agencies, international partners and the private sector. This article describes the coming about of EC3 and its efforts to address cybercrime. Furthermore, the article is an attempt to assess the growing role of the European law enforcement community on the European security scene...

Optimization studies of HgSe thin film deposition by electrochemical atomic layer epitaxy (EC-ALE)

CSIR Research Space (South Africa)

Venkatasamy, V

2006-06-01

Full Text Available Studies of the optimization of HgSe thin film deposition using electrochemical atomic layer epitaxy (EC-ALE) are reported. Cyclic voltammetry was used to obtain approximate deposition potentials for each element. These potentials were then coupled...

The EC Maritime Industries Forum 1992: Marine resources and research and development

International Nuclear Information System (INIS)

Jenisch, U.K.

1993-01-01

The Maritime Industries Forum (MIF) of the European Community has prepared a comprehensive report covering all the EC maritime industries. The report, published on October 29, 1992, addresses maritime activities such as shipbuilding, shipping, fishing, energy, marine resources and environmental protection. Focal points are research and development measures and strategies. A major objective is to strengthen the competitiveness of the maritime industries via a global and horizontal approach. This paper briefly analyses the M.I.F. Report and concentrates on the EC interests in the field of marine resources such as oil and gas, potable water, aquaculture and fishing, minerals, OTEC/DOWA as well as the environmentally sound technology that is required to allow for a future oriented and sustainable exploitation. Export opportunities for such new technologies and cooperation with third states are an important objective. The proposals of the M.I.F. Report are of a positive, future-oriented nature, appropriate to replace many of the hitherto defensive policies in the maritime area. The industries recognize the responsibility for the revitalization of their industrial sectors. The method of this broad sectoral approach for a new industrial policy in Europe is innovative and a model in itself. With the installation of three specialized new industrial panels in January 1993 the work continues

La ergonomía en el sector de la construcción: el método EC2

OpenAIRE

Cerda, Eduardo; Hernández Soto, Aquiles Carlos; Rodríguez Mondelo, Pedro Manuel; Álvarez Casado, Enrique; Rodríguez, Carolina

2009-01-01

Este artículo presenta el método EC2, el cual ha sido diseñado para evaluar el riesgo de trastornos lumbares durante tareas de manipulación manual de materiales realizada en el sector de la construcción. El método EC2 recurre a estándares existentes, métodos para evaluar riesgos de desórdenes lumbares y métodos para optimizar procesos productivos. Propone una ecuación para calcular el índice de riesgo basado en criterios fisiológicos, biomecánicos, psicofísicos y organizacionales. Elementos t...

AMENDING REGULATION (EC NO.1346/2000 ON INSOLVENCY PROCEEDINGS - SOLVING DEFICIENCIES OR ATTEMPT TO RESCUE COMPANIES IN DIFFICULTY?

Directory of Open Access Journals (Sweden)

GABRIELA FIERBINŢEANU

2013-05-01

Full Text Available EC Insolvency Regulation claims, after more than 10 years, several changes imposed by some of the issues raised by the practice of its application but also by the need to promote economic recovery for enterprises in difficulty in the current economic crisis. This paper analyzes the major segments of change and aims to determine whether these segments provide a coherent answer for the practical difficulties faced by the EC Regulation and whether extending its scope by revising the definition of insolvency proceedings may offer better chances of recovery for the enterprises in difficulty.

eHealth services and Directive on Electronic Commerce 2000/31/EC.

Science.gov (United States)

Van Gyseghem, Jean-Marc

2008-01-01

We often restrict the analysis of eHealth services to a concept of privacy. In this article, we'll demonstrate that other legislation can apply to those services as Directive 2000/31/EC on Ecommerce. By creating telematic networks or infrastructure, eHealth services are offering information services. But what are the consequences with such concept? What are the duties and rights for the actors of the network(s)? We'll try to answer to some questions, even if it won't be exhaustive.

The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.

Directory of Open Access Journals (Sweden)

Rikard Dammen

Full Text Available We recently demonstrated that hypoxia, a key feature of IBD, increases enterochromaffin (EC cell 5-HT secretion, which is also physiologically regulated by the ADORA2B mechanoreceptor. Since hypoxia is associated with increased extracellular adenosine, we wanted to examine whether this nucleotide amplifies HIF-1α-mediated 5-HT secretion.The effects of hypoxia were studied on IBD mucosa, isolated IBD-EC cells, isolated normal EC cells and the EC cell tumor derived cell line KRJ-1. Hypoxia (0.5% O2 was compared to NECA (adenosine agonist, MRS1754 (ADORA2B receptor antagonist and SCH442146 (ADORA2A antagonist on HIF signaling and 5-HT secretion. Antisense approaches were used to mechanistically evaluate EC cells in vitro. PCR and western blot were used to analyze transcript and protein levels of HIF-1α signaling and neuroendocrine cell function. An animal model of colitis was evaluated to confirm hypoxia:adenosine signaling in vivo.HIF-1α is upregulated in IBD mucosa and IBD-EC cells, the majority (~90% of which express an activated phenotype in situ. Hypoxia stimulated 5-HT release maximally at 30 mins, an effect amplified by NECA and selectively inhibited by MRS1754, through phosphorylation of TPH-1 and activation of VMAT-1. Transient transfection with Renilla luciferase under hypoxia transcriptional response element (HRE control identified that ADORA2B activated HIF-1α signaling under hypoxic conditions. Additional signaling pathways associated with hypoxia:adenosine included MAP kinase and CREB. Antisense approaches mechanistically confirmed that ADORA2B signaling was linked to these pathways and 5-HT release under hypoxic conditions. Hypoxia:adenosine activation which could be reversed by 5'-ASA treatment was confirmed in a TNBS-model.Hypoxia induced 5-HT synthesis and secretion is amplified by ADORA2B signaling via MAPK/CREB and TPH-1 activation. Targeting ADORA2s may decrease EC cell 5-HT production and secretion in IBD.

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

Czech Academy of Sciences Publication Activity Database

Tlaskalová-Hogenová, Helena; Štěpánková, Renata; Kozáková, Hana; Hudcovic, Tomáš; Vannucci, Luca; Tučková, Ludmila; Rossmann, Pavel; Hrnčíř, Tomáš; Kverka, Miloslav; Zákostelská, Zuzana; Klimešová, Klára; Přibylová, Jaroslava; Bártová, J.; Sánchez, Daniel; Fundová, P.; Borovská, Dana; Šrůtková, Dagmar; Zídek, Zdeněk; Schwarzer, Martin; Drastich, P.; Funda, David P.

2011-01-01

Roč. 8, č. 2 (2011), s. 110-120 ISSN 1672-7681 R&D Projects: GA ČR GA303/08/0367; GA ČR GA303/09/0449; GA ČR GA310/07/0414; GA ČR GA305/08/0535; GA ČR GA310/09/1640; GA ČR GD310/08/H077; GA AV ČR IAA500200710; GA AV ČR KJB500200904; GA AV ČR IAA500200917; GA AV ČR IAA500200709; GA MŠk 2B06053; GA MŠk 2B06155; GA MZd NS9775; GA MZd NS10054; GA MZd(CZ) NS10340; GA MŠk 7E09091 Institutional research plan: CEZ:AV0Z50200510; CEZ:AV0Z50390512 Keywords : allergy * hygiene hypothesis * intestinal permeability Subject RIV: EC - Immunology Impact factor: 2.992, year: 2011

Thermal-hydraulic analyses of the TN-24P cask loaded with consolidated and unconsolidated spent nuclear fuel

International Nuclear Information System (INIS)

Michener, T.E.; McKinnon, M.A.; Rector, D.R.; Creer, J.M.

1989-06-01

This paper presents the results of comparisons of COBRA-SFS (spent fuel storage) temperature predictions with experimental data from the TN-24P (Transnuclear) spent fuel storage cask loaded with unconsolidated and consolidated spent PWR fuel. Peak cladding temperature predictions using the COBRA-SFS code are compared with test data and predicted axial and radial temperature distributions are compared with measured temperature profiles. The pre-test accuracy of the COBRA-SFS code in predicting temperature distributions is discussed, along with the effect of post-test model improvements on temperature predictions. This paper also briefly describes the COBRA-SFS code, which is designed to accurately predict flow and temperature distributions in spent nuclear fuel storage and transportation systems. 6 refs., 14 figs

TN trademark FLEX: a new generation of fluorocarbon o-rings developed by COGEMA logistics with enhanced characteristics at low temperature (-40 C)

International Nuclear Information System (INIS)

Issard, H.; Andre, R.

2004-01-01

Three main types of elastomers are used for the sealing of radioactive material transport casks with elastomeric gaskets: EPDM, fluorocarbons type Viton registered (standard designation: FKM) and silicon rubbers. Each rubber has specific characteristics in terms of temperature range, permeability, coefficient of expansion.. For the casks where high temperatures can be reached (200 C in continuous using), FKM gaskets are generally used. The problem is that this type of gasket does not guarantee the leaktightness at -40 C, which is a regulatory requirement. Two solutions are generally used: to specify a minimum heat load or a minimum ambient temperature. The direct consequence is that it is impossible to get B(U) approvals on the new concepts when FKM gaskets are used but only B(M) approvals, which generate significant additional justification costs (multiple submittals of Safety Analysis Reports, calculation of the minimum heat load or of the minimum ambient temperature..). Thus, it is important to develop gaskets with the same performance as FKM gaskets at high temperature but with enhanced performance at low temperature (and mainly, which guarantee the leaktightness at -40 C). COGEMA LOGISTICS has qualified a new generation of fluorocarbon O-rings (TN trademark FLEX gaskets) which can be used in continuous service on a -47 C/+200 C temperature range. TN trademark FLEX gaskets will be implemented on new casks designs

The 'deep' independent system operator. A new sophisticated institutional design for system operators in the 3rd energy package of September 2007 in comparison to the Proposal of the 8 EC-Member States for a Directive of the EP and the Council amending Directive 2003/54/EC concerning common rules for the internal market in electricity and repealing Directive 96/92/EC. A German perspective on implementing an effective and efficient unbundling of Transmission System Operator

International Nuclear Information System (INIS)

Saecker, F.J.

2008-01-01

The ownership unbundling-model and the 'deep' ISO-model (ISO stands for Independent System Operator) are not compatible with the EC-Treaty, if they were realized against the interest of the shareholder's assembly. The proposal of the eight EC member states for an effective and efficient unbundling avoids the constitutional problems and strengthens the independence of transmission system operators

Assessment of vulnerability zones for ground water pollution using GIS-DRASTIC-EC model: A field-based approach

Science.gov (United States)

Anantha Rao, D.; Naik, Pradeep K.; Jain, Sunil K.; Vinod Kumar, K.; Dhanamjaya Rao, E. N.

2018-06-01

Assessment of groundwater vulnerability to pollution is an essential pre-requisite for better planning of an area. We present the groundwater vulnerability assessment in parts of the Yamuna Nagar District, Haryana State, India in an area of about 800 km2, considered to be a freshwater zone in the foothills of the Siwalik Hill Ranges. Such areas in the Lower Himalayas form good groundwater recharge zones, and should always be free from contamination. But, the administration has been trying to promote industrialization along these foothill zones without actually assessing the environmental consequences such activities may invite in the future. GIS-DRASTIC model has been used with field based data inputs for studying the vulnerability assessment. But, we find that inclusion electrical conductivity (EC) as a model parameter makes it more robust. Therefore, we rename it as GIS-DRASTIC-EC model. The model identifies three vulnerability zones such as low, moderate and high with an areal extent of 5%, 80% and 15%, respectively. On the basis of major chemical parameters alone, the groundwater in the foothill zones apparently looks safe, but analysis with the help of GIS-DRASTIC-EC model gives a better perspective of the groundwater quality in terms of identifying the vulnerable areas.

Influence of a {sup 99m}TcN core on the biological and physicochemical behavior of {sup 99m}Tc complexes of L,L-EC and L,L-ECD

Energy Technology Data Exchange (ETDEWEB)

Mangera, Kennedy O; Vanbilloen, Hubert P.; Bellande, Emmanuel; Pasqualini, Roberto; Verbruggen, Alfons M

1996-11-01

{sup 99m}Tc-nitrido complexes of L,L-ethylene dicysteine ({sup 99m}TcN-L,L-EC) and {sup 99m}TcN-L,L-ethylene dicysteine diethylester ({sup 99m}TcN-L,L-ECD) were prepared and their characteristics compared to those of the respective {sup 99m}Tc-oxo complexes. {sup 99m}TcN-L,L-EC and {sup 99m}TcO-L,L-EC migrate to similar extents during electrophoresis at pH 12, but, at pH 6, {sup 99m}TcN-L,L-EC migrates further than {sup 99m}TcO-L,L-EC. Renal excretion of {sup 99m}TcN-L,L-EC is inferior to that of {sup 99m}TcO-L,L-EC, indicating that the TcN-glycine sequence has lower affinity for the renal tubular system. Both {sup 99m}TcO-L,L-ECD and {sup 99m}TcN-L,L-ECD are neutral, but {sup 99m}TcN-L,L-ECD is hydrophilic and shows minimal brain uptake in both mice and the baboon.

EC infuses Serbian nuclear relic cleanup with critical donation

International Nuclear Information System (INIS)

2008-01-01

. In addition to the radiological legacy at Vinca, security had long been a source of concern. The reactor has been offline since 1984, and much of the dangerous material and facilities were inadequately protected. Thanks to funding and other support activities provided by the Serbian government and the USA for security upgrades and police support, overall site security has been substantially improved over the past two years. Yet more needs to be done, and time is running out. Along with the EC's recent donation, an additional $25 million must be raised by 2010 to meet a crucial deadline. The fuel needs to be shipped back to Russia by the end of 2010 or the job falls off the shipping schedule, and potential funding for VIND would also dry up should the 2010 target date be missed. VIND is the largest one-house programme within the IAEA, and the EC contribution is the largest single contribution ever received for a Technical Cooperation (TC) national project. 'The EC support was absolutely crucial to the life of the programme, but we have quite a way to go to find the remaining $25 million for the project,' said Kelly. 'The EC contribution serves as a great example and encourages other potential donors to invest in an important and successful project.' Background: Located on the outskirts of Belgrade, the 'Institute for Nuclear Sciences (Vinca)' was set up as a research centre in the former Yugoslavia in the 1950s. A civilian nuclear research reactor loaded with high-enriched uranium was housed at the site. The area was also a central radioactive waste collection and consolidation centre for the former Yugoslavia. The grounds at Vinca accumulated all the former country's dangerous radioactive waste and other radioactive sources for nearly 45 years, and though the reactor went offline in 1984, the radioactive waste and sources received from around the country continued to pile up. International concern about Vinca mushroomed in the 1990s after the break-up of the former

EC treatment for reuse of tissue paper wastewater: aspects that affect energy consumption.

Science.gov (United States)

Terrazas, Eduardo; Vázquez, Armando; Briones, Roberto; Lázaro, Isabel; Rodríguez, Israel

2010-09-15

The need for more rational use of water also calls for more efficient usage. An example is the production of tissue paper, where large amounts of water are discharged into the drain because its turbidity does not allow for recirculation. While this is a serious problem, even worse is the fact that the quality of such wastewater makes it difficult not only to recirculate but also to discharge due to environmental law restrictions. In this paper, electrocoagulation is proposed as a suitable technology to meet standards of water discharge, and even better, as a treatment option for removal of turbidity. Since energy consumption has been a drawback for EC applications, relevant aspects that contribute to increase it such as cell voltage and current density have been reviewed. For this purpose a systematic micro-electrolysis study combined with macro-electrolysis experiments have provided evidence that shows it is possible to achieve a turbidity removal of 92% with an energy consumption of 0.68 kWh/m(3). Thus, the results presented in this paper support the use of EC to obtain water of acceptable quality for reuse in the tissue paper industry. Copyright 2010 Elsevier B.V. All rights reserved.

"EC to go" takes off at Maryland sites.

Science.gov (United States)

2000-03-01

Baltimore-based Planned Parenthood of Maryland and the Baltimore City Health Department have joined forces in "EC to Go," which distributes free emergency contraceptive pills (ECPs) through the seven affiliate sites of Planned Parenthood and the three family planning centers of the city. The distribution program was started in October 1999 and funds were provided by an undisclosed area foundation. Although the program is still in its infancy, it has recorded some 800 prescriptions of ECPs in the last fiscal year, and 600 prescriptions have been logged in just the first 6 months of the current fiscal year. To inform the public about the program, Planned Parenthood developed newspaper advertisements, a 60-second radio spot, and coupon distributions, all of which emphasize the fact that emergency contraception is a higher dose of birth control, which can prevent pregnancy if taken within 72 hours of unprotected sex.

Ariadne merione ecdysone receptor (AmEcR protein: An in silico approach for comparison of agonist and antagonist compounds

Directory of Open Access Journals (Sweden)

Chandran Sundaravadivelan

2017-12-01

Full Text Available Ecdysteroid signal transduction plays a major role in insect metamorphosis, 20-hydroxyecdysone (20E binds to the nuclear receptor composed of the ecdysone receptor ligand binding domine (EcR-LBD and triggers the developmental transitions. Ariadne merione ecdysone receptor (AmEcR cDNA was amplified and partially sequenced of about 553 bp, which encodes a polypeptide of 184 amino acids (aa. The theoretical molecular weight (MW, isoelectric point (pI and aliphatic index of the deduced AmEcR protein were predicted using BIOEDIT (v7.2.5 to be 21.192 kDa, 9.31 and 101.739 respectively. Identified ecdysone receptor gene of A. merione showed maximum similarity with Precis coenia gene. In this research, we have employed ligand-receptor engineering technique to screen a specific compound which plays antagonist role and assist to formulate an insect specific pesticide. The EcR protein 3D structure of AmEcR modeled using Schrödinger maestro and virtual screening was performed using 5554 molecules from Zinc database, where ZINC20031812 showed highest glide score of −6.257 and Etoxazole chosen on literature basis and showed best glide score −6.671. We have compared the antagonist with agonist (20E by molecular dynamics (MD simulation. Root Mean Square Deviation (RMSD value of agonist and antagonist indicates the binding were stable in water with a range of distance from 2.3 to 2.6 Å, 1.8 to 2.3 Å and 1.9 to 2.3 Å with a variation over the time scale of 1 ps. Since Etoxazole and ZINC20031812 are antagonists, computationally they were more stable than 20E. Keywords: Ariadne merione, 20 Hydroxyecdysone (20E, Etoxazole, Schrödinger

Electrochemically Pretreated Carbon Microfiber Electrodes as Sensitive HPLC-EC Detectors

Directory of Open Access Journals (Sweden)

Zdenka Bartosova

2012-01-01

Full Text Available The paper focuses on the analysis and detection of electroactive compounds using high-performance liquid chromatography (HPLC combined with electrochemical detection (EC. The fabrication and utilization of electrochemically treated carbon fiber microelectrodes (CFMs as highly sensitive amperometric detectors in HPLC are described. The applied pretreatment procedure is beneficial for analytical characteristics of the sensor as demonstrated by analysis of the model set of phenolic acids. The combination of CFM with separation power of HPLC technique allows for improved detection limits due to unique electrochemical properties of carbon fibers. The CFM proved to be a promising tool for amperometric detection in liquid chromatography.

Achievements & bottlenecks in humanitarian demining EU-funded research: Final results from the EC DELVE project

NARCIS (Netherlands)

Sahli, H.; Bruschini, C.; Kempen, L. van; Schleijpen, H.M.A.; Breejen, E. den

2008-01-01

The EC DELVE Support Action project has analyzed the bottlenecks in the transfer of Humanitarian Demining (HD) technology from technology development to the use in the field, and drawn some lessons learned, basing itself on the assessment of the European Humanitarian Demining Research and Technology

The macro-sectoral effects of an EC-wide tax. Simulation experiments for 1993-2005

Energy Technology Data Exchange (ETDEWEB)

Standaert, S. [Department of Quantitative Economics. Rijksuniversiteit Limburg, Maastricht (Netherlands)

1992-03-01

The results of simulations of the possible macro-sectoral effects of an EC-wide energy tax of 10$ per barrel of oil over the period 1993-2005 are presented. The level of the tax is held constant in real terms. Two alternative redistribution schemes ensure that the tax is budget-neutral country-wise: a reduction of personal income taxes (Direct Taxation scenario or DT), and a reduction of employers social security contributions (Social Security scenario or SS). The simulations were performed with linked multi-sectoral Hermes models maintained at the DG 12 of the Committee of the European Communities. The eventual goal is to shed some light on the implications of an EC-wide environmental policy relying on economic instruments. The tool used enables to present results which are original in certain respects. In particular, in contrast with most existing studies in this area, we use a disaggregated model over a fairly long period of time. The disaggregation has two dimensions, since we link national models, which are themselves disaggregated into industries. This should enable us to get a firmer grip on the implications of the policies followed on the structure of the European economies. In order to limit the costs of disaggregation we have included only four complete country models (France, Germany, Italy and the United Kingdom) in the simulations, which cover nevertheless a substantial proportion of EC value-added. Another noteworthy feature of the model is its fairly detailed treatment of energy. This and other characteristics of the model are reviewed in greater detail in Section 2, which provides general information on the model and on the way in which the various shocks have been calibrated. The sections 3 and 4 discuss respectively the DT and the SS scenarios. Additional variants are reviewed in section 5, before the conclusions.

Calculation of Savannah River K Reactor Mark-22 assembly LOCA/ECS power limits

International Nuclear Information System (INIS)

Fischer, S.R.; Farman, R.F.; Birdsell, S.A.

1992-01-01

This paper summarizes the results of TRAC-PF1/MOD3 calculations of Mark-22 fuel assembly of loss-of-coolant accident/emergency cooling system (LOCA/ECS) power limits for the Savannah River Site (SRS) K Reactor. This effort was part of a larger effort undertaken by the Los Alamos National Laboratory for the US Department of Energy to perform confirmatory power limits calculations for the SRS K Reactor. A method using a detailed three-dimensional (3D) TRAC model of the Mark-22 fuel assembly was developed to compute LOCA/ECS power limits. Assembly power was limited to ensure that no point on the fuel assembly walls would exceed the local saturation temperature. The detailed TRAC model for the Mark-22 assembly consisted of three concentric 3D vessel components which simulated the two targets, two fuel tubes, and three main flow channels of the fuel assembly. The model included 100% eccentricity between the assembly annuli and a 20% power tilt. Eccentricity in the radial alignment of the assembly annuli arises because axial spacer ribs that run the length of the fuel and targets are used. Wall-shear, interfacial-shear, and wall heat-transfer correlations were developed and implemented in TRAC-PF1/MOD3 specifically for modeling flow and heat transfer in the narrow ribbed annuli encountered in the Mark-22 fuel assembly design. We established the validity of these new constitutive models using separate-effects benchmarks. TRAC system calculations of K Reactor indicated that the limiting ECS-phase accident is a double-ended guillonite break in a process water line at the pump discharge (i.e., a PDLOCA). The fuel assembly with the minimum cooling potential is identified from this system calculation. Detailed assembly calculations then were performed using appropriate boundary conditions obtained from this limiting system LOCA. Coolant flow rates and pressure boundary conditions were obtained from this system calculation and applied to the detailed assembly model

Photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav and V345 Pav

Science.gov (United States)

Bruch, Albert

2017-10-01

As part of a project to better characterize comparatively bright, yet little studied cataclysmic variables time resolved photometry of the three eclipsing novalike variables EC 21178-5417, GS Pav und V345 Pav is presented. Previously known orbital periods are significantly improved and long-term ephemeris are derived. Variations of eclipse profiles, occurring on time scales of days to weeks, are analyzed. Out of eclipse the light curves are characterized by low scale flickering superposed on more gradual variations with amplitudes limited to a few tenths of a magnitude and profiles which at least in EC 21178-5417 and GS Pav roughly follow the same pattern in all observed cycles. Additionally, signs for variations on the time scale of some tens of minutes are seen in GS Pav, most clearly in two subsequent nights when in the first of these a signal with a period of 15.7 min was observed over several hours. In the second night variations with twice this period were seen. While no additional insight could be gained on quasi periodic oscillations (QPOs) and dwarf nova oscillations in EC 21178-5417, previously detected by Warner et al. (2003), and while such oscillations could not be found in V345 Pav, stacked power spectra of GS Pav clearly reveal the presence of QPOs over time intervals of several hours with periods varying between 200 s and 500 s in that system.

RWMC support to member countries and relationship with the IAEA, EC and other organisations

International Nuclear Information System (INIS)

2006-01-01

This documents provides information on how the work of the NEA/RWMC supports the needs of NEA member countries and how it differs from, and complements, the related work of the IAEA and EC. In particular, the document reviews the respective roles and specificities of these organisations and their modus operandi, including co-operation and co-ordination mechanisms. (authors)

Use of Correlation Relationships to Enhance Understanding of Pedogenic Processes and Use Potential of Vertisols and Vertic Inceptisols of the Bale Mountain Area of Ethiopia

Directory of Open Access Journals (Sweden)

Verdoodt, A.

2009-01-01

Full Text Available Five Vertisols and two Vertic Inceptisols developed from basalt and alluvial materials were characterized for physical and chemical properties. Correlative statistical relationships were established among physical and chemical properties including cation exchange capacity (CEC, percent total clay, electrical conductivity (EC, base saturation % (BS, pH-H2O, pH-KCl, CaCO3 equivalent, organic carbon (OC, total nitrogen (TN, P-Bray and P-Olsen. Correlative relationships were established among parameters for all horizons of the soils studied as well as among parameters within individual horizons. P-Olsen was highly correlated with OC and TN; simple coefficients of determination (r2 were 0.81 and 0.69, respectively. CaCO3 was highly correlated with pH-H2O and pH-KCl; r2 values were 0.68 and 0.60, respectively. Similar correlations were obtained for pHKCl vs pH-H2O and pH-KCl vs EC, with r2 values of 0.92 and 0.70, respectively. Total nitrogen was also very highly correlated with OC (r2= 0.88. Base saturation was highly correlated with pH-KCl and pH-H2O giving r2 values of 0.62 and 0.64, respectively. When correlative relationships were carried out among parameters within individual horizons very high correlation coefficients were obtained for OC vs TN (r= 0.98 - 1.00, OC vs P-Olsen (r= 0.96 - 0.99, BS vs pH-KCl (r= 0.82 - 1.00, BS vs pH-H2O (r= 0.86 - 1.00. Most of the simple correlation coefficients obtained for EC with pH-KCl and pH-H2O were > 0.81. High correlation coefficients (0.80 - 1.00 were obtained for % clay vs total CEC for most soils studied. Regression relationships developed constitute useful predictive indices for estimating agronomic properties from existing physical and chemical data and soil survey reports of the Bale Mountain area of Ethiopia. This study has demonstrated that statistical correlation can be used to cross-check the quality of analytical data both among horizons of different soil profiles and within individual soil

The EC CAST project (carbon-14 source term)

International Nuclear Information System (INIS)

Williams, S. J.

2015-01-01

Carbon-14 is a key radionuclide in the assessment of the safety of underground geological disposal facilities for radioactive wastes. It is possible for carbon-14 to be released from waste packages in a variety of chemical forms, both organic and inorganic, and as dissolved or gaseous species The EC CAST (CArbon-14 Source Term) project aims to develop understanding of the generation and release of carbon-14 from radioactive waste materials under conditions relevant to packaging and disposal. It focuses on the release of carbon-14 from irradiated metals (steels and zirconium alloys), from irradiated graphite and from spent ion-exchange resins. The CAST consortium brings together 33 partners. CAST commenced in October 2013 and this paper describes progress to March 2015. The main activities during this period were reviews of the current status of knowledge, the identification and acquisition of suitable samples and the design of experiments and analytical procedures. (authors)

The human vascular endothelial cell line HUV-EC-C harbors the integrated HHV-6B genome which remains stable in long term culture.

Science.gov (United States)

Shioda, Setsuko; Kasai, Fumio; Ozawa, Midori; Hirayama, Noriko; Satoh, Motonobu; Kameoka, Yousuke; Watanabe, Ken; Shimizu, Norio; Tang, Huamin; Mori, Yasuko; Kohara, Arihiro

2018-02-01

Human herpes virus 6 (HHV-6) is a common human pathogen that is most often detected in hematopoietic cells. Although human cells harboring chromosomally integrated HHV-6 can be generated in vitro, the availability of such cell lines originating from in vivo tissues is limited. In this study, chromosomally integrated HHV-6B has been identified in a human vascular endothelial cell line, HUV-EC-C (IFO50271), derived from normal umbilical cord tissue. Sequence analysis revealed that the viral genome was similar to the HHV-6B HST strain. FISH analysis using a HHV-6 DNA probe showed one signal in each cell, detected at the distal end of the long arm of chromosome 9. This was consistent with a digital PCR assay, validating one copy of the viral DNA. Because exposure of HUV-EC-C to chemicals did not cause viral reactivation, long term cell culture of HUV-EC-C was carried out to assess the stability of viral integration. The growth rate was altered depending on passage numbers, and morphology also changed during culture. SNP microarray profiles showed some differences between low and high passages, implying that the HUV-EC-C genome had changed during culture. However, no detectable change was observed in chromosome 9, where HHV-6B integration and the viral copy number remained unchanged. Our results suggest that integrated HHV-6B is stable in HUV-EC-C despite genome instability.

Comparison of four techniques on facility of two-hand Bag-valve-mask (BVM ventilation: E-C, Thenar Eminence, Thenar Eminence (Dominant hand-E-C (non-dominant hand and Thenar Eminence (non-dominant hand – E-C (dominant hand

Directory of Open Access Journals (Sweden)

Maryam Soleimanpour

2016-12-01

Conclusion: Novice participants did Thenar Eminence (non-dominant hand - E-C (dominant hand technique better than the others. Therefore, it is recommended that training of this technique was placed in educational program of medical students.

Supplementary light and higher fertigation EC in the cultivation of bromelia improve quality and accelerate growth

NARCIS (Netherlands)

Garcia Victoria, N.; Warmenhoven, M.G.

2012-01-01

Abstract: In order to provide Bromelia growers with lacking information about optimal levels of supplementary light and nutrient EC, two consecutive greenhouse experiments were conducted by Wageningen UR Glasshouse Horticulture in Bleiswijk (The Netherlands). In the first experiment a light

Expresión de efectores RXLR en el linaje clonal EC-1 de Phytophthora infestans en Perú

Directory of Open Access Journals (Sweden)

Myriam Izarra

2016-12-01

Full Text Available La papa (Solanum tuberosum L. es en nuestros días uno de los cultivos alimenticios más importantes. Esta es propensa a la enfermedad de Tizón Tardío, causada por el oomiceto patógeno Phytophthora infestans, el cual secreta cientos de efectores que actúan como factores de virulencia. Poco se conoce sobre la diversidad de genes de virulencia de las cepas pertenecientes al linaje de reproducción clonal EC-1. En el presente estudio, mediante el secuenciamiento del transcriptoma de la interacción de la papa y P. infestans durante los primeros días después de la infección en las hojas de papa, se identificó la expresión diferencial de genes efectores tipo RXLR en dos cepas de P. infestans EC-1, siendo confirmados por qRT-PCR. Estas cepas, aisladas de papas cultivadas en el centro de los Andes peruanos, tienen diferentes patrones de virulencia. Los genes efectores, fueron silenciados en una cepa, para Avr-vnt1 en POX109 y para el homólogo Avh9.1 en POX067, pero expresados en la otra. Los resultados de transcriptoma fueron comparados con tres cepas adicionales del linaje EC-1. La información del repertorio de los efectores del patógeno y su expresión podrían ser informativos para el mejoramiento genético de la resistencia. El descubrimiento de efectores silenciados en las poblaciones del patógeno pueden guiar al uso de genes R específicos en los programas de mejoramiento genético. Por ejemplo, en el contexto de los Andes, donde el linaje clonal EC-1 predomina, el gen Rpi-vnt1 podría no ser recomendado.

The median effective concentration (EC50) of propofol with different doses of fentanyl during colonoscopy in elderly patients.

Science.gov (United States)

Li, Shiyang; Yu, Fang; Zhu, Huichen; Yang, Yuting; Yang, Liqun; Lian, Jianfeng

2016-04-21

Propofol and fentanyl are the most widely administered anesthesia maintaining drugs during colonoscopy. In this study, we determined the median effective concentration (EC50) of propofol required for colonoscopy in elderly patients, and the purpose of this study was to describe the pharmacodynamic interaction between fentanyl and propofol when used in combination for colonoscopy in elderly patients. Ninety elderly patients scheduled for colonoscopy were allocated into three groups in a randomized, double-blinded manner as below, F0.5 group (0.5 μg.kg(-1) fentanyl), F1.0 group (1.0 μg.kg(-1) fentanyl) and saline control group. Anaesthesia was achieved by target-controlled infusion of propofol (Marsh model, with an initial plasma concentration of 2.0 μg.ml(-1)) and fentanyl. Colonoscopy was started 3 min after the injection of fentanyl. The EC50 of propofol for colonoscopy with different doses of fentanyl was measured by using an up-and-down sequential method with an adjacent concentration gradient at 0.5 μg.ml(-1) to inhibit purposeful movements. Anaesthesia associated adverse events and recovery characters were also recorded. The EC50 of propofol for colonoscopy in elderly patients were 2.75 μg.ml(-1) (95% CI, 2.50-3.02 μg.ml(-1)) in F0.5 group, 2.05 μg.ml(-1) (95% CI, 1.98-2.13 μg.ml(-1)) in F1.0 group and 3.08 μg.ml(-1) (95% CI, 2.78-3.42 μg.ml(-1)) in control group respectively (P fentanyl up to 1.0 μg.kg(-1) reduces the propofol EC50 required for elderly patients undergoing colonoscopy, and there was no significant difference in anaesthesia associated adverse events but prolonged awake and discharge time. Chinese Clinical Trial Registry ChiCTR15006368. Date of registration: May 3, 2015.

BLT-EC (Breach, Leach and Transport-Equilibrium Chemistry) data input guide. A computer model for simulating release and coupled geochemical transport of contaminants from a subsurface disposal facility

International Nuclear Information System (INIS)

MacKinnon, R.J.; Sullivan, T.M.; Kinsey, R.R.

1997-05-01

The BLT-EC computer code has been developed, implemented, and tested. BLT-EC is a two-dimensional finite element computer code capable of simulating the time-dependent release and reactive transport of aqueous phase species in a subsurface soil system. BLT-EC contains models to simulate the processes (container degradation, waste-form performance, transport, chemical reactions, and radioactive production and decay) most relevant to estimating the release and transport of contaminants from a subsurface disposal system. Water flow is provided through tabular input or auxiliary files. Container degradation considers localized failure due to pitting corrosion and general failure due to uniform surface degradation processes. Waste-form performance considers release to be limited by one of four mechanisms: rinse with partitioning, diffusion, uniform surface degradation, and solubility. Transport considers the processes of advection, dispersion, diffusion, chemical reaction, radioactive production and decay, and sources (waste form releases). Chemical reactions accounted for include complexation, sorption, dissolution-precipitation, oxidation-reduction, and ion exchange. Radioactive production and decay in the waste form is simulated. To improve the usefulness of BLT-EC, a pre-processor, ECIN, which assists in the creation of chemistry input files, and a post-processor, BLTPLOT, which provides a visual display of the data have been developed. BLT-EC also includes an extensive database of thermodynamic data that is also accessible to ECIN. This document reviews the models implemented in BLT-EC and serves as a guide to creating input files and applying BLT-EC

Hardware and software architecture for the integration of the new EC waves launcher in FTU control system

Energy Technology Data Exchange (ETDEWEB)

Boncagni, L. [Associazione EURATOM-ENEA sulla Fusione – ENEA, Via Enrico Fermi, 45 00045 Frascati (RM) (Italy); Centioli, C., E-mail: cristina.centioli@enea.it [Associazione EURATOM-ENEA sulla Fusione – ENEA, Via Enrico Fermi, 45 00045 Frascati (RM) (Italy); Galperti, C.; Alessi, E.; Granucci, G. [Associazione EURATOM-ENEA-CNR sulla Fusione – IFP-CNR, Via Roberto Cozzi, 53 20125 Milano (Italy); Grosso, L.A. [Associazione EURATOM-ENEA sulla Fusione – ENEA, Via Enrico Fermi, 45 00045 Frascati (RM) (Italy); Marchetto, C. [Associazione EURATOM-ENEA-CNR sulla Fusione – IFP-CNR, Via Roberto Cozzi, 53 20125 Milano (Italy); Napolitano, M. [Associazione EURATOM-ENEA sulla Fusione – ENEA, Via Enrico Fermi, 45 00045 Frascati (RM) (Italy); Nowak, S. [Associazione EURATOM-ENEA-CNR sulla Fusione – IFP-CNR, Via Roberto Cozzi, 53 20125 Milano (Italy); Panella, M. [Associazione EURATOM-ENEA sulla Fusione – ENEA, Via Enrico Fermi, 45 00045 Frascati (RM) (Italy); Sozzi, C. [Associazione EURATOM-ENEA-CNR sulla Fusione – IFP-CNR, Via Roberto Cozzi, 53 20125 Milano (Italy); Tilia, B.; Vitale, V. [Associazione EURATOM-ENEA sulla Fusione – ENEA, Via Enrico Fermi, 45 00045 Frascati (RM) (Italy)

2013-10-15

Highlights: ► The integration of a new ECRH launcher to FTU legacy control system is reported. ► Fast control has been developed with a three-node RT cluster within MARTe framework. ► Slow control was implemented with a Simatic S7 PLC and an EPICS IOC-CA application. ► The first results have assessed the feasibility of the launcher control architecture. -- Abstract: The role of high power electron cyclotron (EC) waves in controlling magnetohydrodynamic (MHD) instabilities in tokamaks has been assessed in several experiments, exploiting the physical effects induced by resonant heating and current drive. Recently a new EC launcher, whose main goal is controlling tearing modes and possibly preventing their onset, is being implemented on FTU. So far most of the components of the launcher control strategy have been realized and successfully tested on plasma experiments. Nevertheless the operations of the new launcher must be completely integrated into the existing one, and to FTU control system. This work deals with this final step, proposing a hardware and software architecture implementing up to date technologies, to achieve a modular and effective control strategy well integrated into a legacy system. The slow control system of the new EC launcher is based on a Siemens S7 Programmable Logic Controller (PLC), integrated into FTU control system supervisor through an EPICS input output controller (IOC) and an in-house developed Channel Access client application creating an abstraction layer that decouples the IOC and the PLC from the FTU Supervisor software. This architecture could enable a smooth migration to an EPICS-only supervisory control system. The real time component of the control system is based on the open source MARTe framework relying on a Linux real time cluster, devoted to the detection of MHD instabilities and the calculation of the injection angles and the time reference for the radiofrequency power enable commands for the EC launcher.

Vegetation relevés and soil measurements in the Netherlands: the Ecological Conditions Database (EC)

NARCIS (Netherlands)

Wamelink, G.W.W.; Adrichem, van M.H.C.; Dobben, van H.F.; Frissel, J.Y.; Held, den M.E.; Joosten, V.; Malinowska, A.H.; Slim, P.A.; Wegman, R.M.A.

2012-01-01

Since its establishment around 1990, the Ecological Conditions Database (EC; GIVD ID EU-00-006) has been accumulating vegetation relevés from the Netherlands, each accompanied by at least one abiotic soil measurement (e.g. pH or nutrient availability). On 1-1-2010, the database contained 8,229

First detection of the staphylococcal trimethoprim resistance gene dfrK and the dfrK-carrying transposon Tn559 in enterococci.

Science.gov (United States)

López, María; Kadlec, Kristina; Schwarz, Stefan; Torres, Carmen

2012-02-01

The trimethoprim resistance gene dfrK has been recently described in Staphylococcus aureus, but so far has not been found in other bacteria. A total of 166 enterococci of different species (E. faecium, E. faecalis, E. hirae, E. durans, E. gallinarum, and E. casseliflavus) and origins (food, clinical diseases in humans, healthy humans or animals, and sewage) were studied for their susceptibility to trimethoprim as determined by agar dilution (European Committee on Antimicrobial Susceptibility Testing) and the presence of (a) the dfrK gene and its genetic environment and (b) other dfr genes. The dfrK gene was detected in 49% of the enterococci (64% and 42% of isolates with minimum inhibitory concentrations of ≥2 mg/L or ≤1 mg/L, respectively). The tet(L)-dfrK linkage was detected in 21% of dfrK-positive enterococci. The chromosomal location of the dfrK gene was identified in one E. faecium isolate in which the dfrK was not linked to tet(L) gene but was part of a Tn559 element, which was integrated in the chromosomal radC gene. This Tn559 element was also found in 14 additional isolates. All combinations of dfr genes were detected among the isolates tested (dfrK, dfrG, dfrF, dfrK+dfrG, dfrK+dfrF, dfrF+dfrG, and dfrF+dfrG+dfrK). The gene dfrK gene was found together with other dfr genes in 58% of the tested enterococci. This study suggested an exchange of the trimethoprim resistance gene dfrK between enterococci and staphylococci, as previously observed for the trimethoprim resistance gene dfrG.

Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.

Science.gov (United States)

Papagiannitsis, Costas C; Kutilova, Iva; Medvecky, Matej; Hrabak, Jaroslav; Dolejska, Monika

2017-09-01

A total of 18 Enterobacteriaceae (17 from gulls and 1 from a clinical sample) collected from Australia, carrying IncA/C plasmids with the IMP-encoding In809-like integrons, were studied. Seven plasmids, being representatives of different origins, plasmid sizes, replicon combinations, and resistance genes, were completely sequenced. Plasmid pEc158, identified in a clinical Escherichia coli ST752 isolate, showed extensive similarity to type 2 IncA/C 2 plasmids. pEc158 carried none of the bla CMY-2 -like region or ARI-B and ARI-A regions, while it contained a hybrid transposon structure. The six remaining plasmids, which were of wildlife origin, were highly similar to each other and probably were fusion derivatives of type 1 and type 2 A/C 2 plasmids. The latter plasmids contained an ARI-B region and hybrid transposon structures. In all plasmids, hybrid transposon structures containing In809-like integrons were inserted 3,434 bp downstream of the rhs2 start codon. In all cases, the one outermost 38-bp inverted repeat (IR) of the transposon was associated with the Tn 1696 tnp module, while the other outermost 38-bp IR of the transposon was associated with either a Tn 6317 -like module or a Tn 21 mer module. However, the internal structure of the transposon and the resistance genes were different in each plasmid. These findings indicated that, for the specific periods of time and settings, different IncA/C 2 plasmid types carrying In809-like elements circulated among isolates of wildlife and clinical origins. Additionally, they provided the basis for speculations regarding the reshuffling of IncA/C 2 plasmids with In809-like integrons and confirmed the rapid evolution of IncA/C 2 plasmid lineages. Copyright © 2017 American Society for Microbiology.

Extreme drought decouples silicon and carbon geochemical linkages in lakes.

Science.gov (United States)

Li, Tianyang; Li, Siyue; Bush, Richard T; Liang, Chuan

2018-09-01

Silicon and carbon geochemical linkages were usually regulated by chemical weathering and organism activity, but had not been investigated under the drought condition, and the magnitude and extent of drought effects remain poorly understood. We collected a comprehensive data set from a total of 13 sampling sites covering the main water body of the largest freshwater lake system in Australia, the Lower Lakes. Changes to water quality during drought (April 2008-September 2010) and post-drought (October 2010-October 2013) were compared to reveal the effects of drought on dissolved silica (DSi) and bicarbonate (HCO 3 - ) and other environmental factors, including sodium (Na + ), pH, electrical conductivity (EC), chlorophyll a (Chl-a), total dissolved solids (TDS), dissolved inorganic nitrogen (DIN), total nitrogen (TN), total phosphorus (TP) and water levels. Among the key observations, concentrations of DSi and DIN were markedly lower in drought than in post-drought period while pH, EC and concentrations of HCO 3 - , Na + , Chl-a, TDS, TN, TP and the ratio TN:TP had inverse trends. Stoichiometric ratios of DSi:HCO 3 - , DSi:Na + and HCO 3 - :Na + were significantly lower in the drought period. DSi exhibited significantly negative relationships with HCO 3 - , and DSi:Na + was strongly correlated with HCO 3 - :Na + in both drought and post-drought periods. The backward stepwise regression analysis that could avoid multicollinearity suggested that DSi:HCO 3 - ratio in drought period had significant relationships with fewer variables when compared to the post-drought, and was better predictable using nutrient variables during post-drought. Our results highlight the drought effects on variations of water constituents and point to the decoupling of silicon and carbon geochemical linkages in the Lower Lakes under drought conditions. Copyright © 2018 Elsevier B.V. All rights reserved.

The exposure of the EC (European Community) population from nuclear industry effluents

International Nuclear Information System (INIS)

Broomfield, M.

1983-01-01

The collective dose commitment to the EC population from routine effluents released from nuclear power stations and reprocessing plants within the Community in 1978 amounted to approximately 500 man Sv. The collective dose commitments associated with discharges from the nuclear power stations was approximately 50 man Sv, being almost entirely due to airborne carbon-14. The total collective dose commitment from the reprocessing plants was approximately 450 man Sv, about two-thirds of which was due to radiocaesium in the liquid effluent from Sellafield. (UK)

Programming Amazon Web Services S3, EC2, SQS, FPS, and SimpleDB

CERN Document Server

Murty, James

2009-01-01

With this book, you'll learn how companies can take advantage of Amazon Web Services (AWS) to rent" computing power, data storage and bandwidth on Amazon's vast network infrastructure. Programming Amazon Web Services gives developers the background and technical detail they need for using Amazon's subscription-based Simple Storage Service (S3), Elastic Compute Cloud (EC2), Simple Queue Service (SQS), Flexible Payments Service (FPS), and SimpleDB to build web-scale business applications. "

Ecdysone receptor (EcR) and ultraspiracle (USP) genes from the cyclopoid copepod Paracyclopina nana: Identification and expression in response to water accommodated fractions (WAFs).

Science.gov (United States)

Puthumana, Jayesh; Lee, Min-Chul; Han, Jeonghoon; Kim, Hui-Su; Hwang, Dae-Sik; Lee, Jae-Seong

2017-02-01

Ecdysteroid hormones are pivotal in the development, growth, and molting of arthropods, and the hormone pathway is triggered by binding ecdysteroid to a heterodimer of the two nuclear receptors; ecdysone receptors (EcR) and ultraspiracle (USP). We have characterized EcR and USP genes, and their 5'-untranslated region (5'-UTR) from the copepod Paracyclopina nana, and studied mRNA transcription levels in post-embryonic stages and in response to water accommodated fractions (WAFs) of crude oil. The open reading frames (ORF) of EcR and USP were 1470 and 1287bp that encoded 490 and 429 amino acids with molecular weight of 121.18 and 105.03kDa, respectively. Also, a well conserved DNA-binding domain (DBD) and ligand-binding domain (LBD) were identified which confirmed by phylogenetic analysis. Messenger RNA transcriptional levels of EcR and USP were developmental stage-specific in early post-embryonic stages (N3-4). However, an evoked expression of USP was observed throughout copepodid stage and in adult females. WAFs (40 and 80%) were acted as an ecdysone agonist in P. nana, and elicited the mRNA transcription levels in adults. Developmental stage-specific transcriptional activation of EcR and USP in response to WAFs was observed. USP gene was down-regulated in the nauplius in response to WAF, whereas up-regulation of USP was observed in the adults. This study represents the first data of molecular elucidation of EcR and USP genes and their regulatory elements from P. nana and the developmental stage specific expression in response to WAFs, which can be used as potential biomarkers for environmental stressors with ecotoxicological evaluations in copepods. Copyright © 2016 Elsevier Inc. All rights reserved.

Effects of dexmedetomidine on H-FABP, CK-MB, cTnI levels, neurological function and near-term prognosis in patients undergoing heart valve replacement.

Science.gov (United States)

Wang, Zhi; Chen, Qiang; Guo, Hao; Li, Zhishan; Zhang, Jinfeng; Lv, Lei; Guo, Yongqing

2017-12-01

This study investigated the effects of dexmedetomidine on heart-type fatty acid binding protein (H-FABP), creatine kinase isoenzymes (CK-MB), and troponin I (cTnI) levels, neurological function and near-term prognosis in patients undergoing heart valve replacement. Patients undergoing heart valve replacement were randomly allocated to remifentanil anesthesia (control group, n=48) or dexmedetomidine anesthesia (observation group, n=48). Hemodynamic parameters were measured before anesthesia induction (T1), 1 min after intubation (T2), 10 min after start of surgery (T3), and on completion of surgery (T4). Levels of plasma H-FABP, CK-MB and cTnI were measured 10 min before anesthesia induction (C1), 10 min after start of surgery (C2), on completion of surgery (C3), 6 h after surgery (C4), and 24 h after surgery (C5). S100β protein and serum neuron-specific enolase (NSE) were detected 10 min before anesthesia induction (C1), and 24 h after surgery (C5). Neurological and cardiac function was evaluated 24 h after surgery. Incidence of cardiovascular adverse events was recorded for 1 year of follow-up. There were no significant differences in the average heart rate between the two groups during the perioperative period. The mean arterial pressure in the observation group was significantly lower than control group (PH-FABP, CK-MB and cTnI at C2, C3, C4 and C5, were significantly higher than C1, but significantly lower in the observation versus control group (P<0.05). Twenty-four hours after surgery, levels of S100β and NSE in both groups were higher than those before induction (P<0.05), but significantly lower in the observation versus control group (P<0.05). Twenty-four hours after surgery, neurological function scores were better, and myocardial contractility and arrhythmia scores significantly lower in the observation versus control group (P<0.05 for all). After follow-up for 1 year, incidence of cardiovascular adverse events was significantly lower in the observation

The EC TACIS project 'Social impact of closing Chornobyl NPP' objectives, tasks and intended outcomes

International Nuclear Information System (INIS)

Schoen, A.

2001-01-01

Being part of the common activities of Slavutich and ChNPP, our EC TACIS project representatives already actively participated in the elaboration of the state programme aimed to ensure the social security of the ChNPP personnel and the population of Slavutich in the result of the final shut down of ChNPP

Pollution characteristics of surface runoff under different restoration types in manganese tailing wasteland.

Science.gov (United States)

Wang, Jun; Cheng, Qingyu; Xue, Shengguo; Rajendran, Manikandan; Wu, Chuan; Liao, Jiaxin

2018-04-01

A great deal of manganese and associated heavy metals (such as Ni, Cu, Zn, Cd, Pb, etc.) was produced in manganese mining, smelting, and other processes and weathering and leaching of waste slag, which entered rainwater runoff by different means under the action of rainfall runoff. It caused heavy metal pollution in water environment to surrounding areas, and then environmental and human health risks were becoming increasingly serious. In the Xiangtan manganese mine, we studied the characteristics of nutritional pollutants and heavy metals by using the method of bounded runoff plots on the manganese tailing wasteland after carrying out some site treatments using three different approaches, such as (1) exposed tailings, the control treatment (ET), (2) external-soil amelioration and colonization of Cynodon dactylon (Linn.) Pers. turf (EC), and (3) external-soil amelioration and seedling seeding propagation of Cynodon dactylon (Linn.) Pers. (ES). The research showed that the maximum runoff occurred in 20,140,712 rainfall events, and the basic law of runoff was EC area > ET area > ES area in the same rainfall event. The concentration of total suspended solids (TSS) and chemical oxygen demand (COD) of three ecological restoration areas adopted the following rule: ET area > EC area > ES area. Nitrogen (N) existed mainly in the form of water soluble while phosphorus (P) was particulate. The highest concentrations of total nitrogen (TN) and total phosphorus (TP) were 11.57 ± 2.99 mg/L in the EC area and 1.42 ± 0.56 mg/L in the ET area, respectively. Cr, Ni, Pb, Zn, Mn, and Cu in surface runoff from three restoration types all exceeded the class V level of the environmental quality standard for surface water except Cu in EC and ES areas. Pollution levels of heavy metals in surface runoff from three restoration areas are shown as follows: ET area > EC area > ES area. There was a significant positive correlation between TSS and runoff, COD, and TP. And this

Phosphatidylserine-exposing blood and endothelial cells contribute to the hypercoagulable state in essential thrombocythemia patients.

Science.gov (United States)

Tong, Dongxia; Yu, Muxin; Guo, Li; Li, Tao; Li, Jihe; Novakovic, Valerie A; Dong, Zengxiang; Tian, Ye; Kou, Junjie; Bi, Yayan; Wang, Jinghua; Zhou, Jin; Shi, Jialan

2018-04-01

The mechanisms of thrombogenicity in essential thrombocythemia (ET) are complex and not well defined. Our objective was to explore whether phosphatidylserine (PS) exposure on blood cells and endothelial cells (ECs) can account for the increased thrombosis and distinct thrombotic risks among mutational subtypes in ET. Using flow cytometry and confocal microscopy, we found that the levels of PS-exposing erythrocytes, platelets, leukocytes, and serum-cultured ECs were significantly higher in each ET group [JAK2, CALR, and triple-negative (TN) (all P cells and serum-cultured ECs led to markedly shortened coagulation time and dramatically increased levels of FXa, thrombin, and fibrin production. This procoagulant activity could be largely blocked by addition of lactadherin (approx. 70% inhibition). Confocal microscopy showed that the FVa/FXa complex and fibrin fibrils colocalized with PS on ET serum-cultured ECs. Additionally, we found a relationship between D-dimer, prothrombin fragment F1 + 2, and PS exposure. Our study reveals a previously unrecognized link between hypercoagulability and exposed PS on cells, which might also be associated with distinct thrombotic risks among mutational subtypes in ET. Thus, blocking PS-binding sites may represent a new therapeutic target for preventing thrombosis in ET.

The application of 99mTc-EC renal dynamic imaging in urinary system calculus

International Nuclear Information System (INIS)

Dai Ruqi; Li Shiyun; Liu Xueshu; Huang Wei

2002-01-01

Objective: To evaluate the clinical value of 99m Tc-EC renal dynamic imaging (RDI) for diagnosis of urinary system calculus. Methods: 135 case with confirmed urinary system calculus by ultrasound and IVP were examined by 99m Tc-EC renal dynamic imaging and to analyze the degree of hydronephrosis and the remaining renal function. The quantitative indexes used were effective renal plasma flow (ERPF) and peak uptake rate (PUR). Results: RDI almost accorded with IVP in renal calculus complicated by mild and moderate hydronephrosis cases. On other cases of the severe hydronephrosis and serious renal insufficiency, RDI was more sensitive than IVP which had no excretion in 6 patients with hydronephrosis. ERPF and PUR showed the remaining function of the morbid kidney more accurately than other methods. In severe and mild hydronephrosis the ERPF were 84.3 ± 49 ml/min and 202.2 ± 52.4 ml/min, the PUR were 20.4 ± 11.5% and 48.5 ± 13.6% respectively. Conclusion: RDI can correctly reflect the degree of hydronephrosis and the remaining function of the morbid kidney in urinary system calculus, which would be helpful for the clinical surgical planning

Seismic slope stability of embankments: a comparative study on EC8 provisions

DEFF Research Database (Denmark)

Zania, Varvara; Tsompanakis, Y.; Psarropoulos, P.N.

2011-01-01

According to EC8 provisions, seismic stability assessment of natural slopes is currently performed based on simplified methods i.e. the pseudostatic and the Newmark’s sliding block method. The application of these methods requires the beforehand consideration of major assumptions necessary...... for the selection of either the seismic coefficient or the acceleration time history of the rigid block. Although both ULS and SLS are defined according to acceptable level of deformations at the slope, the assigned level of displacements is not clarified. In the current study the seismic slope stability...

Conference-EC-US Task Force Joint US-EU Workshop on Metabolomics and Environmental Biotechnology

Energy Technology Data Exchange (ETDEWEB)

PI: Lily Y. Young

2009-06-04

Since 1990, the EC-US Task Force on Biotechnology Research has been coordinating transatlantic efforts to guide and exploit the ongoing revolution in biotechnology and the life sciences. The Task Force was established in June 1990 by the European Commission and the White House Office of Science and Technology Policy. The Task Force has acted as an effective forum for discussion, coordination, and development of new ideas for the last 18 years. Task Force members are European Commission and US Government science and technology administrators who meet annually to enhance communication across the Atlantic, and to encourage collaborative research. Through sponsoring workshops, and other activities, the Task Force also brings together scientific leaders and early career researchers from both sides of the Atlantic to forecast research challenges and opportunities and to promote better links between researchers. Over the years, by keeping a focus on the future of science, the Task Force has played a key role in establishing a diverse range of emerging scientific fields, including biodiversity research, neuroinformatics, genomics, nanobiotechnology, neonatal immunology, transkingdom molecular biology, biologically-based fuels, and environmental biotechnology. The EC-US Task Force has sponsored a number of Working Groups on topics of mutual transatlantic interest. The idea to create a Working Group on Environmental Biotechnology research was discussed in the Task Force meeting of October 1993. The EC-US Working Group on Environmental Biotechnology set as its mission 'To train the next generation of leaders in environmental biotechnology in the United States and the European Union to work collaboratively across the Atlantic.' Since 1995, the Working Group supported three kinds of activities, all of which focus one early career scientists: (1) Workshops on the use of molecular methods and genomics in environmental biotechnology; (2) Short courses with theoretical

Physical, chemical and biological CTD and bottle data from R/V Thomas G. Thompson cruise TN278 in eastern tropical North Pacific Ocean from March 19 to April 20, 2012 (NODC Accession 0109846)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This report contains data from R/V Thomas G. Thompson cruise TN278 to the eastern tropical north pacific oxygen deficient zone. The objective of the cruise was to...

Quality assurance - quality control in the framework of the EC-open market events

International Nuclear Information System (INIS)

Asshauer, S.; Kinzinger, K.

1994-01-01

The declared target of the EC-commission is to merge the national markets into a common market. The companies which are mentioned in the sector guideline and which exceed the determined liminal values in the procurement are forced to submit their demand all over Europe. In this work a report is given on the experiences, procedures and the further developments taking into consideration the quality assurance and the quality control at gas works in Hamburg. (orig.) [de

Gene expression responses linked to reproduction effect concentrations (EC 10,20,50,90 of dimethoate, atrazine and carbendazim, in Enchytraeus albidus.

Directory of Open Access Journals (Sweden)

Sara C Novais

Full Text Available BACKGROUND: Molecular mechanisms of response to pesticides are scarce and information on such responses from soil invertebrates is almost inexistent. Enchytraeus albidus (Oligochaeta is a standard soil ecotoxicology model species for which effects of many pesticides are known on survival, reproduction and avoidance behaviour. With the recent microarray development additional information can be retrieved on the molecular effects. METHODOLOGY/PRINCIPAL FINDINGS: Experiments were performed to investigate the transcription responses of E. albidus when exposed to three pesticides - dimethoate (insecticide, atrazine (herbicide and carbendazim (fungicide - in a range of concentrations that inhibited reproduction by 10%, 20%, 50% and 90% (EC(10, EC(20, EC(50 and EC(90, respectively. The goal of this study was to further identify key biological processes affected by each compound and if dose-related. All three pesticides significantly affected biological processes like translation, regulation of the cell cycle or general response to stress. Intracellular signalling and microtubule-based movement were affected by dimethoate and carbendazim whereas atrazine affected lipid and steroid metabolism (also by dimethoate or carbohydrate metabolism (also by carbendazim. Response to DNA damage/DNA repair was exclusively affected by carbendazim. CONCLUSIONS: Changes in gene expression were significantly altered after 2 days of exposure in a dose-related manner. The mechanisms of response were comparable with the ones for mammals, suggesting across species conserved modes of action. The present results indicate the potential of using gene expression in risk assessment and the advantage as early markers.

Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice

Directory of Open Access Journals (Sweden)

Tomoko Kawakami

2012-01-01

although, HO activity was significantly (P<0.05 attenuated along with attenuation of serum adiponectin and vascular epoxide levels (P<0.05. CoPP, in EC-SOD(−/− mice, enhanced HO activity (P<0.05 and reversed aforementioned pathophysiological abnormalities along with restoration of vascular EET, p-eNOS, p-AKT and serum adiponectin levels in these animals. Taken together our results implicate a causative role of insufficient activation of heme-HO-adiponectin system in pathophysiological abnormalities observed in animal models of chronic oxidative stress such as EC-SOD(−/− mice.

Improved design of an ITER equatorial EC launcher

International Nuclear Information System (INIS)

Takahashi, K.; Kajiwara, K.; Kobayashi, N.; Kasugai, A.; Sakamoto, K.

2008-01-01

New design improvements for an ITER equatorial EC launcher are described. A design of the front shield modules was evaluated analytically. The results indicate that these modules can withstand the electromagnetic forces induced by plasma disruption and vertical plasma motion. The steering mirror mock-up including the spiral cooling tubes was fabricated based on the present design with application of the hot isostatic pressing technique to bond the copper alloy mirror body and the embedded stainless steel cooling tubes. The test of water flow was carried out and the expected flow rate was successfully obtained. A quasi-optical (QO) transmission layout has been proposed instead of the waveguide lines. The advantage of this option is possibly to increase the reliability in terms of fabrication and refurbishment. According to the beam propagation analysis, it is verified that transmission loss at the QO region is 1.1%-2.2%, which is comparable to the reference design. The peak heat load on the steering mirror surface could be reduced by 55%, which relaxes the mirror design

Zbiornik w wyrobisku końcowym Odkrywki "Pątnów" Kopalni Węgla Brunatnego "Konin" i jego bilans wodny za okres 2003-2004

OpenAIRE

Wachowiak, Grzegorz; Wachowiak, Agata

2005-01-01

The idea of water recultivation and management of the closing open pits in the Lignite Opencast Mine "Konin" is of a growing importance. Hence, the necessity to explore water relations conditioned by SLich undertakings. Recultivation scheme of the closing open pit "Pątnów" of Lignite Opencast Mine "Konin" includes the construction of a 346 ha reservoir with the capacity of over 38 mln m. So far, it is the biggest reservoir built as a result of an open pit reculti...

The competitive advantage of nations: the importance of the national environment for strategic management in the EC

NARCIS (Netherlands)

F.A.J. van den Bosch (Frans); T. Elfring (Tom); P. de Wolf (Peter)

1991-01-01

textabstractSummary: In this paper we investigate the usefulness for strategic management of Porter's framework of analysis of the competitive advantage of nations in particular regarding the importance of the changing national environment within the EC. It appears that Porter's framework

The GPCR membrane receptor, DopEcR, mediates the actions of both dopamine and ecdysone to control sex pheromone perception in an insect

Directory of Open Access Journals (Sweden)

Antoine eAbrieux

2014-09-01

Full Text Available Olfactory information mediating sexual behavior is crucial for reproduction in many animals, including insects. In male moths, the macroglomerular complex of the primary olfactory center, the antennal lobe (AL is specialized in the treatment of information on the female-emitted sex pheromone. Evidence is accumulating that modulation of behavioral pheromone responses occurs through neuronal plasticity via the action of hormones and/or catecholamines. We recently showed that a G-protein-coupled receptor (GPCR, AipsDopEcR, with its homologue known in Drosophila for its double affinity to the main insect steroid hormone 20-hydroxyecdysone (20E, and dopamine (DA, present in the ALs, is involved in the behavioral response to pheromone in the moth, Agrotis ipsilon. Here we tested the role of AipsDopEcR as compared to nuclear 20E receptors in central pheromone processing combining receptor inhibition with intracellular recordings of AL neurons. We show that the sensitivity of AL neurons for the pheromone in males decreases strongly after AipsDopEcR-dsRNA injection but also after inhibition of nuclear 20E receptors. Moreover we tested the involvement of 20E and DA in the receptor-mediated behavioral modulation in wind tunnel experiments, using ligand applications and receptor inhibition treatments. We show that both ligands are necessary and act on AipsDopEcR-mediated behavior. Altogether these results indicate that the GPCR membrane receptor, AipsDopEcR, controls sex pheromone perception through the action of both 20E and DA in the central nervous system, probably in concert with 20E action through nuclear receptors.

EC assisted start-up experiments reproduction in FTU and AUG for simulations of the ITER case

Energy Technology Data Exchange (ETDEWEB)

Granucci, G.; Ricci, D.; Farina, D.; Figini, L. [Associazione EURATOM-ENEA sulla Fusione, IFP-CNR, Via R. Cozzi 53, 20125 Milano (Italy); Cavinato, M. [F4E C/Josep Pla2, Torres Diagonal Litoral - Building 83 08019 Barcelona (Spain); Mattei, M. [CREATE via Claudio 21, 80125 Napoli (Italy); Stober, J. [Max-Planck-Institut für Plasmaphysik, EURATOM Association, Boltzmannstr. 2, 85748 Garching bei München (Germany); Tudisco, O. [Associazione EURATOM-ENEA sulla Fusione, C.R. Frascati, Via E. Fermi 45, 00044 Frascati (Roma) (Italy)

2014-02-12

The breakdown and plasma start-up in ITER are well known issues studied in the last few years in many tokamaks with the aid of calculation based on simplified modeling. The thickness of ITER metallic wall and the voltage limits of the Central Solenoid Power Supply strongly limit the maximum toroidal electric field achievable (0.3 V/m), well below the level used in the present generation of tokamaks. In order to have a safe and robust breakdown, the use of Electron Cyclotron Power to assist plasma formation and current rump up has been foreseen. This has raised attention on plasma formation phase in presence of EC wave, especially in order to predict the required power for a robust breakdown in ITER. Few detailed theory studies have been performed up to nowadays, due to the complexity of the problems. A simplified approach, extended from that proposed in ref[1] has been developed including a impurity multispecies distribution and an EC wave propagation and absorption based on GRAY code. This integrated model (BK0D) has been benchmarked on ohmic and EC assisted experiments on FTU and AUG, finding the key aspects for a good reproduction of data. On the basis of this, the simulation has been devoted to understand the best configuration for ITER case. The dependency of impurity distribution content and neutral gas pressure limits has been considered. As results of the analysis a reasonable amount of power (1 - 2 MW) seems to be enough to extend in a significant way the breakdown and current start up capability of ITER. The work reports the FTU data reproduction and the ITER case simulations.

Evaluation of reliability of EC inspection of VVER SG tubes

International Nuclear Information System (INIS)

Stanic, D.

2001-01-01

Evaluation of eddy current data collected during inspection of VVER steam generators is very complex task because of numerous parameters which have affect on eddy current signals. That was the reason that recently ago INETEC has started related scientific project in order to evaluate the reliability of eddy current (EC) inspection of VVER steam generator (SG) tubing. In the scope of project the following objectives will be investigated: 1. Determination of POD (Probability of detection) of various types degradation cracks, where their basic parameters are variables (basic parameters are depth, length, width, orientation, number) on three different sets of tubes (clean ideal tubes, tubes with pilgering, tubes electroplated with copper) 2. Sizing quality (accuracy, repeatability) (same data sets as defined in 1.) 3. Effect of fill factor on POD and sizing quality. 4. Effect of tube bends on POD and sizing quality. 5. Effect of other tube geometry variations on POD and sizing quality (tube ovality, transition zone region, expanded (rolled) part of tube, dents, dings). Investigation will start with bobbin probe technique which is the most used technique for general purpose VVER tube examination. Since INETEC is the only world company which successfully developed and applied rotating probe technique for VVER SG tubes, scope of the project will be extended on rotating probe technique utilizing 'pancake' and 'point' coil. Method reliability will be investigated first on the huge set of EDM notches representing various defect morphologies and simulating different factors, and the second part will be investigated on sets of degradation defects obtained by artificial corrosion. In the scope of the project the measures for enhancing the method reliability have to be determined. This considers the proper definition of parameters of examination system, as well as establishment of the suitable analysis procedures. This article presents the temporary results of the first part of

Plant Life Management of the EC6 Concrete Containment Structure

Energy Technology Data Exchange (ETDEWEB)

Abrishami, Homayoun; Ricciuti, Rick; Khan, Azhar [CANDU Energy Inc., Mississauga (Canada)

2012-03-15

Aging of reinforced concrete structures due to service conditions, aggressive environments, or accidents may cause their strength, serviceability and durability to decrease over time. Due to the complex nature of safety-related structures in nuclear power plants in comparison to other structures, they possess a number of characteristics that make them comparison to other structures, they possess a number of characteristics that make them unique. These characteristics are: thick concrete cross-sections, heavy reinforcement, often one-side access only, subjected to such ageing stresses as irradiation and elevated temperature, in addition to other typical ageing mechanisms (i. e., exposure to freeze/thaw cycles, aggressive chemicals, etc.) that typically affects other types of non-nuclear structures. For a new plant, the Plant Life Management Program (PLiM) should start in the design process and then continues through construction, plant operation and decommissioning. Hence PLiM must provide not only Ageing Management program (AMP) but also provide requirements on material characteristic and the design criteria as well. The purpose of this paper is to present the Plant Life Management (PLiM) strategy for the concrete containment structure of EC6 (Enhanced CANDU 6) Nuclear Power Plant designed by CANDU Energy Inc. The EC6 is designed for 100-year plant life including a 60-year operating life and an additional 40-year decommissioning period of time. The approach adopted for the PLiM strategy of the concrete containment structure is a preventive one, key areas being: 1) design methodology, 2) material performance and 3) life cycle management and ageing management program. In addition to strength and serviceability, durability is a major consideration during the design phase, service life and up to the completion of decommissioning. Factors affecting durability design include: a) concrete performance, b) structural application, and c) consideration of environmental

Plant Life Management of the EC6 Concrete Containment Structure

International Nuclear Information System (INIS)

Abrishami, Homayoun; Ricciuti, Rick; Khan, Azhar

2012-01-01

Aging of reinforced concrete structures due to service conditions, aggressive environments, or accidents may cause their strength, serviceability and durability to decrease over time. Due to the complex nature of safety-related structures in nuclear power plants in comparison to other structures, they possess a number of characteristics that make them comparison to other structures, they possess a number of characteristics that make them unique. These characteristics are: thick concrete cross-sections, heavy reinforcement, often one-side access only, subjected to such ageing stresses as irradiation and elevated temperature, in addition to other typical ageing mechanisms (i. e., exposure to freeze/thaw cycles, aggressive chemicals, etc.) that typically affects other types of non-nuclear structures. For a new plant, the Plant Life Management Program (PLiM) should start in the design process and then continues through construction, plant operation and decommissioning. Hence PLiM must provide not only Ageing Management program (AMP) but also provide requirements on material characteristic and the design criteria as well. The purpose of this paper is to present the Plant Life Management (PLiM) strategy for the concrete containment structure of EC6 (Enhanced CANDU 6) Nuclear Power Plant designed by CANDU Energy Inc. The EC6 is designed for 100-year plant life including a 60-year operating life and an additional 40-year decommissioning period of time. The approach adopted for the PLiM strategy of the concrete containment structure is a preventive one, key areas being: 1) design methodology, 2) material performance and 3) life cycle management and ageing management program. In addition to strength and serviceability, durability is a major consideration during the design phase, service life and up to the completion of decommissioning. Factors affecting durability design include: a) concrete performance, b) structural application, and c) consideration of environmental

Energy-constrained open-system magmatic processes IV: Geochemical, thermal and mass consequences of energy-constrained recharge, assimilation and fractional crystallization (EC-RAFC)

International Nuclear Information System (INIS)

Wendy A. Bohrson Department of Geological Sciences, Central Washington University, Ellensburg, Washington, 98926, USA; Frank J. Spera Institute for Crustal Studies and Department of Geological Sciences, University of California, Santa Barbara, California, 93106, USA

2003-01-01

A wealth of geochemical and petrological data provide evidence that the processes of fractional crystallization, assimilation, and magma recharge (replenishment) dominate the chemical signatures of many terrestrial igneous rocks. Previous work [Spera and Bohrson, 2001 ; Bohrson and Spera, 2001] has established the importance of integrating energy, species and mass conservation into simulations of complex magma chamber processes. An extended version of the energy-constrained formulation, Energy-Constrained Recharge, Assimilation, Fractional Crystallization (EC-RAFC), tracks mass and compositional variations of melt, cumulates, and enclaves in a magma body undergoing simultaneous recharge, assimilation, and fractional crystallization [Spera and Bohrson, 2002]. Because many EC-RAFC results are distinct from those predicted by extant RAFC formulations, the primary goal of this paper is to present a range of geochemical and mass relationships for selected cases that highlight issues relevant to modern petrology. Among the plethora of petrologic problems that have important, well-documented analogues in nature are the geochemical distinctions that arise when a magma body undergoes continuous versus episodic recharge, the connection between erupted magmas and associated cumulate bodies, the behavior of recharge-fractionation dominated systems (RFC), thermodynamic conditions that promote the formation of enclaves versus cumulates, and the conditions under which magma bodies may be described as chemically homogeneous. Investigation of the effects of continuous versus episodic recharge for mafic magma undergoing RAFC in the lower crust indicates that the resulting geochemical trends for melt and solids are sensitive to the intensity and composition of recharge, suggesting that EC-RAFC may be used as a tool to distinguish the nature of the recharge events. Compared to the record preserved in melts, the geochemical and mass characteristics of solids associated with particular

Radio-sensitization of esophageal cancer EC9706 cells to X ray by histone deacetylase inhibiter Trichostatin A

International Nuclear Information System (INIS)

Lin Xiaoli; Qin Guangyong; Fang Huasheng; Zhang Fengqiu; Ya Huiyuan

2009-01-01

Cell apoptosis and the expression of DNA damage repair-related genes XRCC2, ATM and Lig4 were detected separately by flow cytometry analysis and real-time fluorescence quantitative (RT-PCR), in order to investigate the effect of Trichostatin A (TSA) pre-treatment on the radiosensitivity of esophageal cancer EC9706 cells to X ray in vitro. The results indicate that pre-irradiation exposure to TSA enhances cell apoptotic rate by X ray markedly (P<0.05) and the mRNA levels of XRCC2, ATM and Lig4 (except 8Gy) are up-regulated by X ray individually (P<0.05). TSA alone and TSA in combination with X ray all reduce mRNA levels of XRCC2, ATM and Lig4. In conclusions, TSA may radio-sensitize EC9706 cells to X ray by reducing mRNA levels of XRCC2, ATM and Lig4. (authors)

Acute toxicity of metals and reference toxicants to a freshwater ostracod, Cypris subglobosa Sowerby, 1840 and correlation to EC50 values of other test models

International Nuclear Information System (INIS)

Khangarot, B.S.; Das, Sangita

2009-01-01

The ostracod Cypris subglobosa Sowerby, 1840 static bioassay test on the basis of a 48 h of 50% of immobilization (EC 50 ) has been used to measure the toxicity of 36 metals and metalloids and 12 reference toxicants. Among the 36 metals and metalloids, osmium (Os) was found to be the most toxic in the test while boron (B), the least toxic. The EC 50 values of this study revealed positive linear relationship with the established test models of cladoceran (Daphnia magna), sludge worm (Tubifex tubifex), chironomid larvae (Chironomus tentans), protozoan (Tetrahymena pyriformis), fathead minnow (Pimephales promelas), bluegill sunfish (Lepomis macrochirus), and aquatic macrophyte duckweed (Lemna minor). Correlation coefficients (r 2 ) for 17 physicochemical properties of metals or metal ions and EC 50 s (as pM) were examined by linear regression analysis. The electronegativity, ionization potential, melting point, solubility product of metal sulfides (pK sp ), softness parameter and some other physicochemical characteristics were significantly correlated with EC 50 s of metals to C. subglobosa. The reproducibility of toxicity test was determined using 12 reference toxicants. The coefficient of variability of the EC 50 s ranged from 6.95% to 55.37% and variability was comparable to that noticed for D. magna and other aquatic test models. The study demonstrated the need to include crustacean ostracods in a battery of biotests to detect the presence of hazardous chemicals in soils, sewage sludges, sediments and aquatic systems.

[Raman spectra study on radiation damage in EC9706 cells by 60Cogamma-rays].

Science.gov (United States)

Qi, Jian; Guo, Zheng-Yuan; Zhang, Guang-Shui; Wu, Dian-Yong; Tang, Wei-Yue

2009-07-01

Raman spectrum was used to study the structure and content of protein, nucleic acid and fat, while EC9706 cells irradiated by 60Co gamma-ray were cultivated for 24 h. The results showed that for spectrum intensity and frequency deviation, there were big differences between each exposure group and control group. For the 1 244 cm(-1) peak of amide III, beta folder changed to disordered conformations in the middle dose (4, 5Gy) groups. The 1 341 cm(-1) peak of v (the indole ring of Trp) was red-shifted in every dose group. There was a 2-3 cm(-1) red shift at the 782 cm(-1) peak in the big dose groups (7, 8Gy). It was showed that the non-hydrogenation of v(s)(PO2-) was strengthened due to big dose gamma-rays radiation. There was a 4 cm(-1) blue shift at the 1 446 cm(-1) peak of delta (CH2, CH3). It maybe resulted from 60Co gamma-rays' damage to the film of EC9706 cells. The preferable dose of 60Co gamma-rays may be found by analyzing the variety of the above-mentioned peaks in some dose groups.

Analytical calculation of current drive synergy between LH and EC waves

International Nuclear Information System (INIS)

Dumont, R.; Giruzzi, G.

2001-01-01

An analytical model for the evaluation of electron cyclotron current drive efficiency improvement in lower hybrid current drive regimes is presented. The adjoint equation is written and solved by a perturbation treatment, allowing to derive a response function including both collisional and lower hybrid effects, in the limit where the former still dominate. This allows an analytical demonstration of the current drive synergy effects, previously found by numerical solutions of the kinetic equation. The model is especially useful for the determination of appropriate wave parameters optimizing this synergy effect, such as the EC launching angles suitable for a given LH target plasma. Under these conditions, it is shown that a significant improvement of the ECCD efficiency can be obtained

NATIONAL MINORITIES IN THE LAW OF THE EC/EU

Directory of Open Access Journals (Sweden)

Daniel Šmihula

2008-09-01

Full Text Available In the law of the EC/EU the protection of national minorities is still a marginal matter. The EU has relied on general international law and on a European regional system of international law and, in case of necessity, accepted their norms. But in the 1990s there began a process of “de-economisation of the European integration” and the importance of national minorities became higher. Protection of the national minorities has not become a generally accepted legally binding principle of the EU, although in several legal acts issues of national minorities are mentioned. On the other hand, the political relevance of national minorities´ protection is very high. The importance of protection of national minorities in future will probably grow. It is a result of the adoption of the Charter of Fundamental Rights of the EU (2000 and of the discussions regarding the European constitution and the Treaty of Lisbon.

Gamma radiation and osmotic potential of the nutrient solution differentially affect macronutrient concentrations, pH and EC in chilhuacle pepper fruits

International Nuclear Information System (INIS)

Victor Garcia-Gaytan, Libia Iris Trejo-Tellez; Olga Tejeda-Sartorius; Maribel Ramirez-Martinez; Julian Delgadillo-Martinez; Fernando Carlos Gomez-Merino; Soledad Garcia-Morales

2018-01-01

Chilhuacle pepper (Capsicum annuum L.) seeds were exposed to gamma radiation (GR) doses (0, 10, 80 and 120 Gy), and plants were grown in hydroponics with different osmotic potentials (OP) (- 0.036, - 0.072, - 0.092, and - 0.108 MPa) in the nutrient solution. We measured the nutrient concentrations, pH and electrical conductivity (EC) in fruits at different time points after transplanting (70, 90 and 130 dat), and found the GR, nutrient solution OP and their interactions differentially affected N, P, K, Ca, and Mg concentrations, as well as pH and EC in chilhuacle peppers. (author)

Tratamiento con progestágenos y ECG tras el parto en cabras de la raza Serrana – ecótipo Transmontano

OpenAIRE

Valentim, Ramiro; Azevedo, Jorge Manuel Teixeira de; Correia, Teresa Montenegro; Almeida, José Carlos; Fontes, Paulo J.; Galvão, Lurdes; Maurício, Raimundo; Coelho, Alípio

2003-01-01

El principal objetivo de este trabajo fue estudiar la eficacia de la utilización del tratamiento – FGA + eCG – en la retoma de la actividad ovárica postparto en cabras de la raza portuguesa Serrana, ecótipo Transmontano, paridas a final de la estación reproductiva. Para el efecto, en la ciudad de Bragança (latitud 41° 49' N, longitud 6° 40' W y altitud 720 metros), 30 cabras (2-6 años) de la raza portuguesa Serrana, ecótipo Transmontano, apareadas por monta natural y que parieron sin ningún p...

The legal situation relating to the reprocessing in other EC member countries of spent fuel from German nuclear power stations

International Nuclear Information System (INIS)

Haedrich, H.

1993-01-01

The author states that reprocessing can continue, showing by his analysis that discontinuing the reprocessing of spent fuel from Germany in installations in France or Great Britain would mean a breach of - prior-ranking - Euratom law, which offers equally efficient protection of public security and public health and safety in accordance with the internationally defined and accepted state of the art in science and technology. In addition, such a decision would mean an infringement of the basic principles of the free market economy as laid down by the Euratom treaty and by the EC treaty, as there are no facts or conditions allowing application of the exemption provision given by the EC treaty. (orig./HP) [de

Environmental policies and regulations on the electricity market in EC

International Nuclear Information System (INIS)

Boucher, J.

1990-01-01

The use of natural resources like ground and water, the emissions of noxious gases and particles, the thermal rejections, the production of waste and the noise are the main environmental impacts associated with the production of electricity. Emission regulations and standards have been selected so far by the European Community (EC) and the different Member States to deal with the abatement problem. They simply consist in defining some ceilings or regulations for the different types of noxious gases and particles which are emitted by power plants and forcing the power generation companies to comply with these norms within some pre-determined time period. They can also take the form of a general constraint on the sulfur content of the fuel, for example. Tables of emission limits for various gases from existing and new plants are presented. 3 figs., 8 tabs

Electrochemical Behaviour of a PPy(DBS)/Polyacrylonitrile (PAN):LITF:EC:PC/ Li Cell

DEFF Research Database (Denmark)

Vidanapathirana, K.; Careem, M.A.; Skaarup, Steen

2006-01-01

The electrochemical behaviour of Li rechargeable cells with Polypyrrole (PPy) as the cathode material was investigated using cyclic voltammetry. The PPy used was doped with the large surfactant anion dodecyl benzenesulphonate (DBS-). The cells were constructed with PAN:LiTF:EC:PC gel electrolyte...... with Li as anode. The results indicate that during the first reduction, cations are inserted into the PPy film forming LiDBS neutral salt. During the next oxidation/reduction cycles, the mechanism then switches to anion movement. Cyclic voltammetry studies also verified that complete electrochemical...

Certification of a plutonium dioxide reference material for elemental analyses (EC-NRM 210)

International Nuclear Information System (INIS)

Le Duigou, Y.

1990-01-01

A new EC plutonium reference material is made available in the form of 5g samples of plutonium dioxide powder. Before weighing the material must be calcined at 1 250 0 C for two hours. The plutonium content (880.26 ± 0.44) g.kg -1 has been derived from plutonium measurements performed by three different laboratories each applying a different oxydo-reductive method. The results of the plutonium measurement, the statistical evaluation of the uncertainty of the plutonium content together with information on the impurities present in the material are given in the report

Changes of the value added tax in the tax-harmonization process with EC directives

Directory of Open Access Journals (Sweden)

Andrea Votavová

2005-01-01

Full Text Available The aim of this article is to bring near the topical process of the assimilation the Czech law of value added tax to the EC-directives. The attention will be paid to the development of the harmonization this law in 1993 – 2003 and I will describe and analyse the choice sections of the value added tax law (with the effective date from 1. 5. 2004. I will explain the changes by tax rates.

Acute toxicity of metals and reference toxicants to a freshwater ostracod, Cypris subglobosa Sowerby, 1840 and correlation to EC{sub 50} values of other test models

Energy Technology Data Exchange (ETDEWEB)

Khangarot, B.S., E-mail: bkhangarot@hotmail.com [Ecotoxicology Division, Indian Institute of Toxicology Research (Formerly: Industrial Toxicology Research Centre), Post Box No. 80, Mahatma Gandhi Marg, Lucknow 226001 (India); Das, Sangita [Ecotoxicology Division, Indian Institute of Toxicology Research (Formerly: Industrial Toxicology Research Centre), Post Box No. 80, Mahatma Gandhi Marg, Lucknow 226001 (India)

2009-12-30

The ostracod Cypris subglobosa Sowerby, 1840 static bioassay test on the basis of a 48 h of 50% of immobilization (EC{sub 50}) has been used to measure the toxicity of 36 metals and metalloids and 12 reference toxicants. Among the 36 metals and metalloids, osmium (Os) was found to be the most toxic in the test while boron (B), the least toxic. The EC{sub 50} values of this study revealed positive linear relationship with the established test models of cladoceran (Daphnia magna), sludge worm (Tubifex tubifex), chironomid larvae (Chironomus tentans), protozoan (Tetrahymena pyriformis), fathead minnow (Pimephales promelas), bluegill sunfish (Lepomis macrochirus), and aquatic macrophyte duckweed (Lemna minor). Correlation coefficients (r{sup 2}) for 17 physicochemical properties of metals or metal ions and EC{sub 50}s (as pM) were examined by linear regression analysis. The electronegativity, ionization potential, melting point, solubility product of metal sulfides (pK{sub sp}), softness parameter and some other physicochemical characteristics were significantly correlated with EC{sub 50}s of metals to C. subglobosa. The reproducibility of toxicity test was determined using 12 reference toxicants. The coefficient of variability of the EC{sub 50}s ranged from 6.95% to 55.37% and variability was comparable to that noticed for D. magna and other aquatic test models. The study demonstrated the need to include crustacean ostracods in a battery of biotests to detect the presence of hazardous chemicals in soils, sewage sludges, sediments and aquatic systems.

Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity.

Science.gov (United States)

Prendergast, Jillian M; Galvao da Silva, Ana Paula; Eavarone, David A; Ghaderi, Darius; Zhang, Mai; Brady, Dane; Wicks, Joan; DeSander, Julie; Behrens, Jeff; Rueda, Bo R

Targeted therapeutics that can differentiate between normal and malignant tumor cells represent the ideal standard for the development of a successful anti-cancer strategy. The Sialyl-Thomsen-nouveau antigen (STn or Sialyl-Tn, also known as CD175s) is rarely seen in normal adult tissues, but it is abundantly expressed in many types of human epithelial cancers. We have identified novel antibodies that specifically target with high affinity the STn glycan independent of its carrier protein, affording the potential to recognize a wider array of cancer-specific sialylated proteins. A panel of murine monoclonal anti-STn therapeutic antibodies were generated and their binding specificity and efficacy were characterized in vitro and in in vivo murine cancer models. A subset of these antibodies were conjugated to monomethyl auristatin E (MMAE) to generate antibody-drug conjugates (ADCs). These ADCs demonstrated in vitro efficacy in STn-expressing cell lines and significant tumor growth inhibition in STn-expressing tumor xenograft cancer models with no evidence of overt toxicity.

Mechanical analysis of the EC upper launcher with respect to electromagnetic loads

International Nuclear Information System (INIS)

Vaccaro, A.; Kleefeldt, K.; Spaeh, P.; Strauss, D.

2009-01-01

The design of the EC upper launcher for ITER approaches maturity and thus it needs to be qualified with respect to the critical loads. One major source of critical loads are eddy currents, which are induced in the structure during plasma instabilities, of which the most severe conditions may happen during a vertical displacement event (VDE) followed by a fast current quench. High mechanical loads are then acting on the front end of the cantilevered launcher structure as a consequence of the interaction between the static toroidal field and the eddy currents. The EC upper launcher has a length of about 6 m and the nominal gap to the neighbouring components is 20 mm. The targeted limit for the launcher displacements is 10 mm, when accounting for tolerances in manufacturing, positioning and thermal displacement. The conceptual design of the launcher is at risk to miss this requirement, thus different configurations of the main frame are considered and analysed. Especially, the cross-section of the single wall segment has been varied to identify the most efficient strategy for increasing the stiffness of the structure. For this purpose, the mechanical loads from an upward VDE (linear current decay from 15 to 0 MA within 40 ms) are used as input to a finite element analysis with the ANSYS software tool. The displacement at the free plasma facing end of the launcher is calculated and analyzed. Its main component is in toroidal direction and the effort of mitigation is concentrated primarily on the bottom-wall. The approach satisfies the limitations given by the space requests of the mm-wave system which is to be integrated into the port plug.

Studying of cellular interaction of hairpin-like peptide EcAMP1 from barnyard grass (Echinochloa crusgalli L.) seeds with plant pathogenic fungus Fusarium solani using microscopy techniques.

Science.gov (United States)

Vasilchenko, Alexey S; Yuryev, Mikhail; Ryazantsev, Dmitry Yu; Zavriev, Sergey K; Feofanov, Alexey V; Grishin, Eugene V; Rogozhin, Eugene A

2016-11-01

An interaction of recombinant hairpin-like cationic peptide EcAMP1 with conidia of plant pathogenic fungus Fusarium solani at the cellular level was studied by a combination of microscopic methods. EcAMP1 is from barnyard grass (Echinochloa crusgalli L.), and obtained by heterologous expression in Escherichia coli system. As a result, a direct relationship between hyphal growth inhibition and increasing active peptide concentration, time of incubation and fungal physiological condition has been determined. Dynamics of accumulation and redistribution of the peptide studied on fungal cellular cover and inside the conidia cells has been shown. The dynamics are dependent on time of coupling, as well as, a dissimilarity of EcAMP1 binding with cover of fungal conidia and its stepwise accumulation and diffuse localization in the cytoplasm. Correlation between structural disruption of fungal conidia and the presence of morphological changes has also been found. The correlation was found under the influence of peptide high concentrations at concentrations above 32 μM. The results indicate the presence of a binding of EcAMP1 with the surface of fungal conidia, thus, demonstrating a main specificity for its antifungal action at the cellular level. These results, however, cannot exclude the existence of attendant EcAMP1 action based on its intracellular localization on some specific targets. SCANNING 38:591-598, 2016. © 2016 Wiley Periodicals, Inc. © Wiley Periodicals, Inc.

EC verifications of the infrastructure subsystem; EG-Pruefungen im Teilsystem Infrastruktur

Energy Technology Data Exchange (ETDEWEB)

Koeppel, M. [EISENBAHN-CERT, Bonn (Germany)

2006-07-15

With the entry into force of the TSIs (technical specifications for the interoperability) of the high-speed railway system, a new procedure has been created in Germany for authorizing railway infrastructures to enter service. It involves the nominated body for interoperability, Eisenbahn-Cert (EBC), in a role which inserts it ahead of the Federal Railway Authority (EBA). This article discusses the EC verification procedure on the basis of the experience already accumulated with it and the cases pending at present. It also deals with substantive rules concerning the infrastructure TSIs, comparing them with the national equivalents, and takes a look into the future as regards the rules that are going to be necessary for attaining interoperability for both high-speed railway systems and conventional ones. (orig.)

Mouse repeated electroconvulsive seizure (ECS) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT) side-effects in the treatment of depression.

Science.gov (United States)

van Buel, Erin M; Sigrist, Hannes; Seifritz, Erich; Fikse, Lianne; Bosker, Fokko J; Schoevers, Robert A; Klein, Hans C; Pryce, Christopher R; Eisel, Ulrich Lm

2017-01-01

Electroconvulsive therapy (ECT) is an effective treatment for depression, but can have negative side effects including amnesia. The mechanisms of action underlying both the antidepressant and side effects of ECT are not well understood. An equivalent manipulation that is conducted in experimental animals is electroconvulsive seizure (ECS). Rodent studies have provided valuable insights into potential mechanisms underlying the antidepressant and side effects of ECT. However, relatively few studies have investigated the effects of ECS in animal models with a depression-relevant manipulation such as chronic stress. In the present study, mice were first exposed to chronic social stress (CSS) or a control procedure for 15 days followed by ECS or a sham procedure for 10 days. Behavioral effects were investigated using an auditory fear conditioning (learning) and expression (memory) test and a treadmill-running fatigue test. Thereafter, immunohistochemistry was conducted on brain material using the microglial marker Iba-1 and the cholinergic fibre marker ChAT. CSS did not increase fear learning and memory in the present experimental design; in both the control and CSS mice ECS reduced fear learning and fear memory expression. CSS induced the expected fatigue-like effect in the treadmill-running test; ECS induced increased fatigue in CSS and control mice. In CSS and control mice ECS induced inflammation in hippocampus in terms of increased expression of Iba-1 in radiatum of CA1 and CA3. CSS and ECS both reduced acetylcholine function in hippocampus as indicated by decreased expression of ChAT in several hippocampal sub-regions. Therefore, CSS increased fatigue and reduced hippocampal ChAT activity and, rather than reversing these effects, a repeated ECS regimen resulted in impaired fear learning-memory, increased fatigue, increased hippocampal Iba-1 expression, and decreased hippocampal ChAT expression. As such, the current model does not provide insights into the

Mouse repeated electroconvulsive seizure (ECS does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT side-effects in the treatment of depression.

Directory of Open Access Journals (Sweden)

Erin M van Buel

Full Text Available Electroconvulsive therapy (ECT is an effective treatment for depression, but can have negative side effects including amnesia. The mechanisms of action underlying both the antidepressant and side effects of ECT are not well understood. An equivalent manipulation that is conducted in experimental animals is electroconvulsive seizure (ECS. Rodent studies have provided valuable insights into potential mechanisms underlying the antidepressant and side effects of ECT. However, relatively few studies have investigated the effects of ECS in animal models with a depression-relevant manipulation such as chronic stress. In the present study, mice were first exposed to chronic social stress (CSS or a control procedure for 15 days followed by ECS or a sham procedure for 10 days. Behavioral effects were investigated using an auditory fear conditioning (learning and expression (memory test and a treadmill-running fatigue test. Thereafter, immunohistochemistry was conducted on brain material using the microglial marker Iba-1 and the cholinergic fibre marker ChAT. CSS did not increase fear learning and memory in the present experimental design; in both the control and CSS mice ECS reduced fear learning and fear memory expression. CSS induced the expected fatigue-like effect in the treadmill-running test; ECS induced increased fatigue in CSS and control mice. In CSS and control mice ECS induced inflammation in hippocampus in terms of increased expression of Iba-1 in radiatum of CA1 and CA3. CSS and ECS both reduced acetylcholine function in hippocampus as indicated by decreased expression of ChAT in several hippocampal sub-regions. Therefore, CSS increased fatigue and reduced hippocampal ChAT activity and, rather than reversing these effects, a repeated ECS regimen resulted in impaired fear learning-memory, increased fatigue, increased hippocampal Iba-1 expression, and decreased hippocampal ChAT expression. As such, the current model does not provide insights

EC law relating to legal and technical aspects of natural gas and water supply. EC legal provisions for internal market harmonization of the regime of product specification and standardization, and their unification with German law. EG-Recht der Gas- und Wasserversorgungstechnik. Regelungen der Europaeischen Gemeinschaft zur Harmonisierung der Produktanforderungen und ihre Umsetzung in deutsches Recht

Energy Technology Data Exchange (ETDEWEB)

Rienen, W. van; Wasser, U.

1999-01-01

This new publication presents an analysis of the relevant EC legislation and standards and its impacts for the German industrial branches resulting from implementation in German national law. It is an invaluable source of reference for the German natural gas industry and the water supply sector, as well as licensing and supervisory bodies. The book contains comprehensive information on all aspects of interest to public authorities, marketers and manufacturers, presenting the material in a systematic framework based on EC law and in a way designed to help finding the answers arising in practice. As for example: EU directives and regulatory guides relating to the products of interest (certification, standards); obligations and liabilities of those responsible for manufacture, marketing, installation and application of products; general principles of EC law to be observed in addition to regulatory guides; scope of discretion remaining for the German legislator in implementation of the law; resulting modification of duties and scope for action of the competent public authorities; availability of domestic and EC judicial remedies; how to prevent risks and exploit the rights offered by the law so as to be as successful as possible in the deregulated internal market; novel strategies opened up or called for by the novel legal instruments. (orig./CB)

EC/β+ decay of 161Er

International Nuclear Information System (INIS)

Kalinnikov, V.G.; Ibraheem, Y.S.; Stegailov, V.I.

2004-01-01

Full text: The study of odd-proton nuclei in rare-earth region has been performed to get more information on the nuclear structure of these nuclei. In the framework of a program at the ISOL complex of YASNAPP-2 at JINR to study the decay of odd-nuclei, 161 Er has been investigated. The experiments have been focused on the 161 Ho level scheme populated in the EC/β + decay of 161 Er for which a few results have been previously reported [1,2]. Spectra of single γ-ray, γ-γ coincidence and internal conversion electrons were measured. There are appreciable disagreements between results of some γ-ray intensities obtained by us and in [2]. The greatest difference was for relative γ-ray intensity of the 11.28 keV, which has reported value I γ ∼ 10 (I γ 211 =1000) in [2], but this leads to an overpopulation of the 211 keV level by 14% of the decay [3]. The relative intensities of transitions with Eγ γ211 =1000). Inaccuracy of Iγ in [2] is probably due to a sudden change in the efficiency curve of their Ge(Li) detector in the low energy region while our HPGe detector feature a much smoother variation in the efficiency curve in this γ-ray energy region. Besides, the levels earlier introduced by us in [4], three new levels in 161 Ho were proposed from γ-γ coincidences at energies 693.2 keV, 859.6 keV, and 957.97 keV. Spins, parities and Nilsson quantum characteristics of some 161 Ho levels were established

The EU commission and national governments as partners: EC regulatory expansion in telecommunications 1979-2000

OpenAIRE

Mark Thatcher

2001-01-01

Explicitly or implicitly, general models of European integration claim that EC regulatory expansion involves a struggle for power between Commission and national governments. The Commission is seen as a policy entrepreneur, taking the initiative to drive forward integration (Sandholtz and Zysman 1989). It seeks regulatory expansion due to constraints on its expenditure (Majone 1996, ch4). Neo-functionalists emphasise the Commission's ability to expand its role against the wishes of government...

VLBA DETERMINATION OF THE DISTANCE TO NEARBY STAR-FORMING REGIONS. IV. A PRELIMINARY DISTANCE TO THE PROTO-HERBIG AeBe STAR EC 95 IN THE SERPENS CORE

International Nuclear Information System (INIS)

Dzib, Sergio; Loinard, Laurent; Rodriguez, Luis F.; Mioduszewski, Amy J.; Boden, Andrew F.; Torres, Rosa M.

2010-01-01

Using the Very Long Base Array, we observed the young stellar object EC 95 in the Serpens cloud core at eight epochs from 2007 December to 2009 December. Two sources are detected in our field and are shown to form a tight binary system. The primary (EC 95a) is a 4-5 M sun proto-Herbig AeBe object (arguably the youngest such object known), whereas the secondary (EC 95b) is most likely a low-mass T Tauri star. Interestingly, both sources are non-thermal emitters. While T Tauri stars are expected to power a corona because they are convective while they go down the Hayashi track, intermediate-mass stars approach the main sequence on radiative tracks. Thus, they are not expected to have strong superficial magnetic fields, and should not be magnetically active. We review several mechanisms that could produce the non-thermal emission of EC 95a and argue that the observed properties of EC 95a might be most readily interpreted if it possessed a corona powered by a rotation-driven convective layer. Using our observations, we show that the trigonometric parallax of EC 95 is π = 2.41 ± 0.02 mas, corresponding to a distance of 414.9 +4.4 -4.3 pc. We argue that this implies a distance to the Serpens core of 415 ± 5 pc and a mean distance to the Serpens cloud of 415 ± 25 pc. This value is significantly larger than previous estimates (d ∼ 260 pc) based on measurements of the extinction suffered by stars in the direction of Serpens. A possible explanation for this discrepancy is that these previous observations picked out foreground dust clouds associated with the Aquila Rift system rather than Serpens itself.

Padrões de distribuição da avifauna em área de Ecótono Cerrado-Caatinga no Nordeste do Brasil

OpenAIRE

GONÇALVES, Gabriela Silva Ribeiro

2015-01-01

Ecótono é a zona de transição entre sistemas ecológicos adjacentes, que possui um conjunto de características definido pela força das interações entre os sistemas, tendo muitos mecanismos e fatores que podem afetar a diversidade, sendo o ambiente apontado como o principal responsável pela estruturação da comunidade. Nosso objetivo foi identificar os padrões da diversidade de aves em áreas de ecótono envolvendo a Caatinga e o Cerrado no Nordeste do Brasil, verificando quais variáveis ambientai...

Some transition metal ions complexes of tricine (Tn and amino acids: pH-titration, synthesis and antimicrobial activity

Directory of Open Access Journals (Sweden)

M.E. Zayed

2014-12-01

Full Text Available Equilibrium studies have been carried out on complex formation of M(II (M = Co(II, Cu(II and Zn(II with tricine (Tn and L = amino acids in aqueous solution, at 25 °C and ionic strength of I = 0.1 M (NaNO3. The ternary complexes of amino acids are formed by simultaneous reactions. The concentration distribution of the complexes is evaluated. The solid complexes of [M(II–Tn–Histidine (Hist] have been synthesized and characterized by elemental analysis, infrared, magnetic and conductance measurements. The synthesized complexes have been screened for their antibacterial activities and the complexes show a significant antibacterial activity against four bacterial species: Staphylococcus aureus (Gram +ve, Streptococcus pyogenesr (Gram +ve, Serratia marcescens (Gram −ve and Escherichia coli (Gram −ve. The activity increases by increasing the concentration of the complexes.

Experimental study of the correlation between 99Tcm-EC-MNZ SPECT imaging and the expression of hypoxia inducible factor-1α in tumor tissuse

International Nuclear Information System (INIS)

Chen Jie; Lu Xueguan; Tang Jun; Fan Wo

2005-01-01

Objective: To evaluate the correlation between 99 Tc m -ethylene dicysteinc-metronidazaole ( 99 Tc M -EC-MNZ) SPECT imaging and the expression of hypoxia inducible factor-1α (HIF-1α) in tumor tissue. Methods: Twelve S180 sarcoma-bearing Kunming mice tumor models were established. Hypoxic imaging was obtained by SPECT with 99 Tc m -EC-MNZ and the corresponding tumor/muscle ratios (T/M) were measured. Then the animals were sacrificed and the tumor specimen was resected, the expression of HIF-1α and vascular endothelial growth factor (VEGF) was measured by immunohistochemistry. Results: Three hours after injection of 99 Tc m -EC-MNZ, the T/M ranged from 1.93 to 4.46 (median 3.13). The expression of HIF-1α ranged from 31.2% to 60.8% (median 50.4%) and was linearly correlated with the T/M (t=2.732, r=0.654, P=0.021). The expression of VEGF ranged from 33.8% to 57.5% (median 53.1%) and also linearly correlated with the expression of HIF-1α (t=3.011, r=0.690, P=0.0131). Conclusions: There is linear correlation between 99 Tc m -EC-MNZ hypoxic SPECT imaging and the expression of HIF-1α. Combining them can reliably reflect the hypoxic status of the tumor. (authors)

EC static high-temperature leach test. Summary report of an European Community interlaboratory round robin

International Nuclear Information System (INIS)

Koennecke, R.; Kirsch, J.

1985-01-01

The results of an interlaboratory static high-temperature leach test conducted by the Commission of the European Communities in 1983 over a period of 9 months are compiled and statistically evaluated. A total of 12 laboratories - 10 from Member States of the EC and one from Finland and the USA - provided information concerning the test method and the analytical test results in the frame of a round robin test (RRT). All together these laboratories tested 366 waste from specimens of the borosilicate glass UK 209 containing simulated high-level radioactive waste. Leach tests were performed on the basis of the ''Document on the EC static high-temperature leach test method'' in autoclaves at leaching temperatures of 90 0 C, 110 0 C, 150 0 C, and 190 0 C over time periods of 3,7,14,28 and 56 days using dionized water as leachant. The resulting leachates were analysed for the elemental concentrations of Si,B,Sr,Nd and Cs by all laboratories and for the concentrations of the optional elements Na, Al,Ce,Mo,Cr,Fe,Li,Mg and Zn by some of the participating laboratories. Additionally, the F content of the blank leachates was analysed by all laboratories

TMFunction data: 1672 [TMFunction[Archive

Lifescience Database Archive (English)

Full Text Available S344C ... yes drug transport; inter-domain communication TM6 Multidrug transporter, P...Biochemistry. 2007 Sep 4;46(35):9899-910 Calorimetric assay 0.28 Km (mM) Vinblastine ... MDR1_HUMAN (P08183) Helix ... inter-domain commun...ication; drug transport; substrate translocation; ATPase activity

Genetic analysis of the pelA-pelE cluster encoding the acidic and basic pectate lyases in Erwinia chrysanthemi EC16.

Science.gov (United States)

Barras, F; Chatterjee, A K

1987-10-01

In Erwinia chrysanthemi (EC16) the clustered pelA and pelE genes encode an acidic (pI 4.2) and a basic (pI 10.0) pectate lyase (Pel), respectively. The pelA gene has been isolated on a 1.2 kb restriction fragment and the direction of transcription determined. DNA hybridization analysis showed that the pelE sequence shares DNA homology with pelA but not with pelB or pelC, two genes encoding other Pel species in EC16. Since Pel A and Pel E enzymes showed little similarity in terms of catalytic properties, it is proposed that pelA and pelE are duplicates which have highly diverged.

Amendment of the EC Sewage Sludge Regulation and the German Sewage Sludge Ordinance; Novellierung der EG-Klaerschlammrichtlinie und der deutschen Klaerschlammverordnung

Energy Technology Data Exchange (ETDEWEB)

Bergs, C.G.; Krebsbach, A. [Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Berlin (Germany)

2001-03-01

The EC Sewage Sludge Guideline of 12 June 1996 laid down the boundary conditions for sewage sludge utilisation in agriculture. The purpose of the regulation was the standardisation of member states regulations on sewage sludge treatment and the harmonisation of limiting values for pollutant emissions in the EC member states. [German] Mit der 'Richtlinie des Rates vom 12. Juni 1996 ueber den Schutz der Boeden bei der Verwendung von Klaerschlamm in der Landwirtschaft' (86/278/EWG) hat die Europaeische Kommission EU-weite Rahmenvorgaben fuer die landwirtschaftliche Klaerschlammverwertung geschaffen. Ziel der Richtlinie war es, eine Rechtsangleichung der Regelungen ueber die Klaerschlammverwertung und eine Harmonisierung der Schadstoffgrenzwerte in den Mitgliedstaaten zu erreichen. (orig.)

The effect of the Falcon 460 EC fungicide on soil microbial communities, enzyme activities and plant growth.

Science.gov (United States)

Baćmaga, Małgorzata; Wyszkowska, Jadwiga; Kucharski, Jan

2016-10-01

Fungicides are considered to be effective crop protection chemicals in modern agriculture. However, they can also exert toxic effects on non-target organisms, including soil-dwelling microbes. Therefore, the environmental fate of fungicides has to be closely monitored. The aim of this study was to evaluate the influence of the Falcon 460 EC fungicide on microbial diversity, enzyme activity and resistance, and plant growth. Samples of sandy loam with pH KCl 7.0 were collected for laboratory analyses on experimental days 30, 60 and 90. Falcon 460 EC was applied to soil in the following doses: control (soil without the fungicide), dose recommended by the manufacturer, 30-fold higher than the recommended dose, 150-fold higher than the recommended dose and 300-fold higher than the recommended dose. The observed differences in the values of the colony development index and the eco-physiological index indicate that the mixture of spiroxamine, tebuconazole and triadimenol modified the biological diversity of the analyzed groups of soil microorganisms. Bacteria of the genus Bacillus and fungi of the genera Penicillium and Rhizopus were isolated from fungicide-contaminated soil. The tested fungicide inhibited the activity of dehydrogenases, catalase, urease, acid phosphatase and alkaline phosphatase. The greatest changes were induced by the highest fungicide dose 300-fold higher than the recommended dose. Dehydrogenases were most resistant to soil contamination. The Phytotoxkit test revealed that the analyzed fungicide inhibits seed germination capacity and root elongation. The results of this study indicate that excessive doses of the Falcon 460 EC fungicide 30-fold higher than the recommended dose to 300-fold higher than the recommended dose) can induce changes in the biological activity of soil. The analyzed microbiological and biochemical parameters are reliable indicators of the fungicide's toxic effects on soil quality.

EC-directive optical radiation - present state of consultation; EG-Richtlinie optische Strahlung - aktueller Beratungsstand

Energy Technology Data Exchange (ETDEWEB)

Pipke, R. [Bundesanstalt fuer Arbeitschutz und Arbeitsmedizin, Dortmund (Germany)

2004-07-01

The draft of a directive on the protection of workers from risks related to radiation in the range from 100 nm to 1 mm (Laser, UV-radiation) is discussed on EC-level. The European concept of regulations on occupational safety and health is outlined and put into reference with other directives on the protection against physical agents (vibrations, noise, electromagnetic fields). Building up on this the present state of consultation of a directive on optical radiation is represented, including major points of consideration. (orig.)

Jung's dissociable psyche and the ec-static self.

Science.gov (United States)

Austin, Sue

2009-11-01

Much of Jung's later work assumes that the self is an a priori phenomenon in which centripetal dynamics dominate. There is, however, another current in Jung's writings which recognizes the self to be an emergent phenomenon. This view is increasingly prevalent in post-Jungian discourse, and Louis Zinkin's exploration of a post-Jungian-constructivist model of the self can be seen as part of this tendency. My paper privileges an emergent understanding of the self by focusing on the 'unravelling', 'de-centring', centrifugal experiences of otherness in the psyche. It offers a post-Jungian reading of a number of writers who have been influenced by the psychoanalyst Jean Laplanche and proposes a model of the self which focuses on our fantasies, terrors and longings about coming undone and bringing others undone. This model is then linked to Judith Butler's understanding of the self as an ec-static phenomenon, in which the self is, of necessity, outside itself, such that 'there is no final moment in which my return to myself takes place'. I suggest that Jung's early clinical researches into the dissociability of the psyche and the clinical tools which he developed as a result of this work are especially suitable for engaging with these emergent, centrifugal dynamics.

Harmonisation of fire testing of conveyor belts for underground applications within the EC; Harmonisierung der brandtechnischen Pruefverfahren von Foerdergurten fuer den Einsatz unter Tage innerhalb der EG

Energy Technology Data Exchange (ETDEWEB)

Foit, W. [DMT-Gesellschaft fuer Forschung und Pruefung mbH, Dortmund (Germany). Fachstelle fuer Brand- und Explosionsschutz unter Tage - Versuchsgrube Tremonia

1998-12-01

The mining countries of the EC still have different regulations for fire testing of conveyor belts. The test methods will be harmonized for the Common Market, and requirements on conveyor belts will be standardized within the EC. A new EC standard will be drawn up. [Deutsch] Zur Zeit sind in den bergbaubetreibenden Laendern der EG noch unterschiedliche Verfahren zur brandtechnischen Pruefung von Foerdergurten vorgeschrieben. Mit dem Inkrafttreten des Gemeinsamen Marktes und der damit zusammenhaengenden Forderung nach Abbau von Handelshemmnissen sollen diese Pruefverfahren harmonisiert werden. Ziel ist es, die an die Foerdergurte zu stellenden brandtechnischen Anforderungen innerhalb der EG zu vereinheitlichen. Es soll deshalb eine europaeische Norm zur Beurteilung des Brandverhaltens und der Brandausbreitung an Foerdergurten fuer den Kohlenbergbau unter Tage erstellt werden. (orig./MSK)

Core Analysis Combining MT (TIPPER) and Dielectric Sensors (Sans EC) in Earth and Space

Science.gov (United States)

Mound, Michael C.; Dudley, Kenneth L.

2015-01-01

On terrestrial planets and moons of our solar system cores reveal details about a geological structure's formation, content, and history. The strategy for the search for life is focused first on finding water which serves as a universal solvent, and identifying the rocks which such solvent act upon to release the constituent salts, minerals, ferrites, and organic compounds and chemicals necessary for life. Dielectric spectroscopy measures the dielectric properties of a medium as a function of frequency. Reflection measurements in the frequency range from 300 kHz to 300 MHz were carried out using RF and microwave network analyzers interrogating SansEC Sensors placed on clean geological core samples. These were conducted to prove the concept feasibility of a new geology instrument useful in the field and laboratory. The results show that unique complex frequency spectra can be acquired for a variety of rock core samples. Using a combination of dielectric spectroscopy and computer simulation techniques the magnitude and phase information of the frequency spectra can be converted to dielectric spectra. These low-frequency dielectric properties of natural rock are unique, easily determined, and useful in characterizing geology. TIPPER is an Electro-Magnetic Passive-Source Geophysical Method for Detecting and Mapping Geothermal Reservoirs and Mineral Resources. This geophysical method uses distant lightning and solar wind activity as its energy source. The most interesting deflections are caused by the funneling of electrons into more electrically conductive areas like mineralized faults, water or geothermal reservoirs. We propose TIPPER to be used with SansEC for determining terrain/ocean chemistry, ocean depth, geomorphology of fracture structures, and other subsurface topography characteristics below the ice crust of Jovian moons. NASA envisions lander concepts for exploration of these extraterrestrial icy surfaces and the oceans beneath. One such concept would use a

"Me? Teach Science?" Exploring EC-4 Pre-Service Teachers' Self Efficacy in an Inquiry-Based Constructivist Physics Classroom

Science.gov (United States)

Narayan, Ratna; Lamp, David

2010-01-01

In this qualitative and interpretive study, we investigated factors that influenced elementary preservice teachers' self-efficacy in a constructivist, inquiry-based physics class. Bandura's (1977) theory of social learning was used as a basis to examine preservice teacher's self-efficacy. Participants included 70 female EC-4 preservice teachers…

NTM stabilization by alternating O-point EC current drive using a high-power diplexer

Science.gov (United States)

Kasparek, W.; Doelman, N.; Stober, J.; Maraschek, M.; Zohm, H.; Monaco, F.; Eixenberger, H.; Klop, W.; Wagner, D.; Schubert, M.; Schütz, H.; Grünwald, G.; Plaum, B.; Munk, R.; Schlüter, K. H.; ASDEX Upgrade Team

2016-12-01

At the tokamak ASDEX Upgrade, experiments to stabilize neoclassical tearing modes (NTMs) by electron cyclotron (EC) heating and current drive in the O-points of the magnetic islands were performed. For the first time, injection into the O-points of the revolving islands was performed via a fast directional switch, which toggled the EC power between two launchers synchronously to the island rotation. The switching was performed by a resonant diplexer employing a sharp resonance in the transfer function, and a small frequency modulation of the feeding gyrotron around the slope of the resonance. Thus, toggling of the power between the two outputs of the diplexer connected to two articulating launchers was possible. Phasing and control of the modulation were performed via a set of Mirnov coils and appropriate signal processing. In the paper, technological issues, the design of the diplexer, the tracking of the diplexer resonance to the gyrotron frequency, the generation and processing of control signals for the gyrotron, and the typical performance concerning switching contrast and efficiency are discussed. The plasma scenario is described, and plasma experiments are presented, where the launchers scanned the region of the resonant surface continuously and also where the launchers were at a fixed position near to the q  =  1.5-surface. In the second case, complete stabilization of a 3/2 NTM could be reached. These experiments are also seen as a technical demonstration for the applicability of diplexers in large-scale ECRH systems.