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Sample records for v-notch results show

  1. Effect of V Notch Shape on Fatigue Life in Steel Beam Made of AISI 1037

    Directory of Open Access Journals (Sweden)

    Qasim Bader

    2014-04-01

    Full Text Available The present work encompasses effect of V notch shape with various geometries and dimensions on fatigue life behavior in steel beam made of Medium Carbon Steel AISI 1037 which has a wide application in industry. Fatigue life of notched specimens is calculated using the fatigue life obtained from the experiments for smooth specimens (reference and by use Numerical method (FEA.The fatigue experiments were carried out at room temperature, applying a fully reversed cyclic load with the frequency of (50Hz and mean stress equal to zero (R= -1, on a cantilever rotating-bending fatigue testing machine. The stress ratio was kept constant throughout the experiment. Different instruments have been used in this investigation like Chemical composition analyzer type (Spectromax ,Tensile universal testing machine type (WDW-100E ,Hardness tester type (HSV- 1000 , Fatigue testing machine model Gunt WP 140, Optical Light Microscope (OLM and Scanning Electron Microscope (SEM were employed to examine the fracture features . The results show that there is acceptable error between experimental and numerical works .

  2. STRESS FIELD AT A TIP OF A PREFABRICATED SPIRAL V-NOTCH

    Institute of Scientific and Technical Information of China (English)

    郑周练; 陈山林; 叶晓明

    2004-01-01

    Based on the tranditional V-notched blasting,a technique of spirally V-notched blasting to loosen earth and rock was presented.Fracture mechanics and Westergaard stress function were adopted to build a complex stress function to derive the plane stress and strain fields at one tip of the crack under a quasi-static pressure.An expression was formulated to define the stress intensity factor of spiral V-notch loosen blasting.Factors that have effects on the stress intensity factor were studied.It is demonstrated that spiral V-notch loosen blasting is an extension of vertical V-notch blasting,straight cracking,and alike theories.

  3. Critical applied stresses for a crack initiation from a sharp V-notch

    Directory of Open Access Journals (Sweden)

    L. Náhlík

    2014-10-01

    Full Text Available The aim of the paper is to estimate a value of the critical applied stress for a crack initiation from a sharp V-notch tip. The classical approach of the linear elastic fracture mechanics (LELM was generalized, because the stress singularity exponent differs from 0.5 in the studied case. The value of the stress singularity exponent depends on the V-notch opening angle. The finite element method was used for a determination of stress distribution in the vicinity of the sharp V-notch tip and for the estimation of the generalized stress intensity factor depending on the V-notch opening angle. Critical value of the generalized stress intensity factor was obtained using stability criteria based on the opening stress component averaged over a critical distance d from the V-notch tip and generalized strain energy density factor. Calculated values of the critical applied stresses were compared with experimental data from the literature and applicability of the LEFM concept is discussed.

  4. Material inertia and size effects in the Charpy V-notch test

    DEFF Research Database (Denmark)

    Desandre, D. A.; Benzerga, A. A.; Tvergaard, Viggo;

    2004-01-01

    The effect of material inertia on the size dependence of the absorbed energy in the Charpy V-notch test is investigated. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation and the re......The effect of material inertia on the size dependence of the absorbed energy in the Charpy V-notch test is investigated. The material response is characterized by an elastic-viscoplastic constitutive relation for a porous plastic solid, with adiabatic heating due to plastic dissipation...

  5. The evaluation of tempered martensite embrittlement in 4130 steel by instrumented charpy V-notch testing

    Science.gov (United States)

    Zia-Ebrahimi, F.; Krauss, G.

    1983-06-01

    Tempered martensite embrittlement (TME) was studied in vacuum-melted 4130 steel with either 0.002 or 0.02 wt pct P. TME was observed as a severe decrease in Charpy V-notch impact energy, from 46 ft-lb. at 200 °C to 35 ft-lb. at 300 °C in the low P alloy. The impact energy of the high P alloy was consistently lower than that of the low P alloy in all tempered conditions. Fracture was transgranular for all specimens; therefore, segregation of P to the prior austenitic grain boundaries was not a factor in the o°Currence of TME. Analysis of load-time curves obtained by instrumented Charpy testing revealed that the embrittlement is associated with a drop in the pre-maximum-load and post-unstable-fracture energies. In specimens tempered at 400 °C the deleterious effect of phosphorus on impact energy became pronounced, a result more consistent with classical temper embrittlement rather than TME. A constant decrease in pre-maximum-load energy due to phosphorus content was observed. The pre-maximum-load energy decreases with increasing tempering temperature in the range of 200 °C to 400 °C, a result explained by the change in work hardening rate. Carbon extraction replicas of polished and etched as-quenched specimens revealed the presence of Fe2MoC and/or Fe3C carbides retained after austenitizing. Ductile crack extension close to the notch root was related to the formation of fine micro voids at the retained carbides.

  6. Weld investigations by 3D analyses of Charpy V-notch specimens

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Needleman, Allan

    2005-01-01

    The Charpy impact test is a standard procedure for determining the ductile-brittle transition in welds. The predictions of such tests have been investigated by full three dimensional transient analyses of Charpy V-notch specimens. The material response is characterised by an elastic-viscoplastic ......The Charpy impact test is a standard procedure for determining the ductile-brittle transition in welds. The predictions of such tests have been investigated by full three dimensional transient analyses of Charpy V-notch specimens. The material response is characterised by an elastic...... parameters in the weld material differ from those in the base material, and the heat a®ected zone (HAZ) tends to be more brittle than the other material regions. The effect of weld strength undermatch or overmatch is an important issue. Some specimens, for which the notched surface is rotated relative...

  7. Analysis of the Charpy V-notch test for welds

    DEFF Research Database (Denmark)

    Tvergaard, Viggo; Needleman, A.

    2000-01-01

    strength variations in a weldment in a HY100 steel. The predicted work to fracture shows a strong sensitivity to the location of the notch relative to the weld, with the most brittle behavior for a notch close to the narrow heat affected zone. The analyses illustrate the strong dependence of the transition...

  8. Evaluation of fracture toughness in dental ceramics using indentation and SEVNB (Single Edge V-Notched Beam)-method; Avaliacao da tenacidade a fratura de ceramicas dentarias atraves do metodo de entalhe - SEVNB (Single Edge V-Notched Beam)

    Energy Technology Data Exchange (ETDEWEB)

    Santos, L.A.; Santos, C.; Souza, R.C.; Ribeiro, S. [Universidade de Sao Paulo (DEMAR/EEL/USP), Lorena, SP (Brazil). Escola de Engenharia de Lorena. Dept. de Engenharia de Materiais. Polo Urbo-Industrial; Strecker, K. [Universidade Federal de Sao Joao del-Rei (DME/UFSJ), MG (Brazil). Dept. de Materiais Eletricos; Oberacker, R. [Karlsruhe Univ. (Germany)

    2009-07-01

    In this work, the fracture toughness of different ceramics based on Al{sub 2}O{sub 3} and ZrO{sub 2} were evaluated using, comparatively two methods, Vickers indentation and SEVNB (Single Edge V-Notched Beam) method. Al{sub 2}O{sub 3}, ZrO{sub 2}(3%Y{sub 2}O{sub 3}) micro-particled and ZrO{sub 2}(3%Y{sub 2}O{sub 3}) nanometric, ZrO{sub 2}-Al{sub 2}O{sub 3} and Al{sub 2}O{sub 3}-ZrO{sub 2} composites were sintered at different temperatures. Samples were characterized by relative density, X-ray diffraction, SEM, and mechanical evaluation by hardness, bending strength and fracture toughness obtained by ickers indentation and SEVNB-method. The results were presented comparing the densification and microstructural results. Furthermore, the advantages and limitations of each method were discussed. (author)

  9. Effects of Notch Misalignment and Tip Radius on Displacement Field in V-Notch Rail Shear Test as Determined by Photogrammetry

    Science.gov (United States)

    Hill, Charles S.; Oliveras, Ovidio M.

    2011-01-01

    Evolution of the 3D strain field during ASTM-D-7078 v-notch rail shear tests on 8-ply quasi-isotropic carbon fiber/epoxy laminates was determined by optical photogrammetry using an ARAMIS system. Specimens having non-optimal geometry and minor discrepancies in dimensional tolerances were shown to display non-symmetry and/or stress concentration in the vicinity of the notch relative to a specimen meeting the requirements of the standard, but resulting shear strength and modulus values remained within acceptable bounds of standard deviation. Based on these results, and reported difficulty machining specimens to the required tolerances using available methods, it is suggested that a parametric study combining analytical methods and experiment may provide rationale to increase the tolerances on some specimen dimensions, reducing machining costs, increasing the proportion of acceptable results, and enabling a wider adoption of the test method.

  10. METHOD TO CALCULATE STRESS INTENSITY FACTOR OF V-NOTCH IN BI-MATERIALS

    Institute of Scientific and Technical Information of China (English)

    Youtang Li; Ming Song

    2008-01-01

    Based on Zak's stress function,the eigen-equation of stress singularity of bi-materials with a Ⅴ-notch was obtained.A new definition of stress intensity factor for a perpendicular inter facial Ⅴ-notch of bi-material was put forward.The effects of shear modulus and Poisson's ratio of the matrix material and attaching material on eigen-values were analyzed.A generalized ex pression for calculating KI of the perpendicular V-notch of bi-materials was obtained by means of stress extrapolation.Effects of notch depth,notch angle and Poisson's ratio of materials on the singular stress field near the tip of the Ⅴ-notch were analyzed systematically with numerical simulations.As an example,a finite plate with double edge notches under uniaxial uniform ten sion was calculated by the method presented and the influence of the notch angle and Poisson's ratio on the stress singularity near the tip of notch was obtained.

  11. Assessment of Ductile-to-Brittle Transition Behavior of Localized Microstructural Regions in a Friction-Stir Welded X80 Pipeline Steel with Miniaturized Charpy V-Notch Testing

    Science.gov (United States)

    Avila, Julian A.; Lucon, Enrico; Sowards, Jeffrey; Mei, Paulo Roberto; Ramirez, Antonio J.

    2016-06-01

    Friction-stir welding (FSW) is an alternative welding process for pipelines. This technology offers sound welds, good repeatability, and excellent mechanical properties. However, it is of paramount importance to determine the toughness of the welds at low temperatures in order to establish the limits of this technology. Ductile-to-brittle transition curves were generated in the present study by using a small-scale instrumented Charpy machine and miniaturized V-notch specimens (Kleinstprobe, KLST); notches were located in base metal, heat-affected, stirred, and hard zones within a FSW joint of API-5L X80 Pipeline Steel. Specimens were tested at temperatures between 77 K (-196 °C) and 298 K (25 °C). Based on the results obtained, the transition temperatures for the base material and heat-affected zone were below 173 K (-100 °C); conversely, for the stirred and hard zones, it was located around 213 K (-60 °C). Fracture surfaces were characterized and showed a ductile fracture mechanism at high impact energies and a mixture of ductile and brittle mechanisms at low impact energies.

  12. Certification of Charpy V-notch Reference Test Pieces of 80 J Nominal Absorbed Energy (ERM®-FA015x and ERM®-FA015y)

    OpenAIRE

    LAMBERTY MARIE ANDREE; Dean, Alan; Roebben, Gert

    2011-01-01

    This certification report describes the processing and characterisation of ERM®-FA015x and ERM®-FA015y, two batches of Charpy V-notch certified reference test pieces. Sets of five of these test pieces are used for the verification of pendulum impact test machines according to EN 10045-2 (Charpy impact test on metallic materials, Part 2. Method for the verification of impact testing machines) or according to ISO 148-2 (Metallic materials - Charpy pendulum impact test – Part 2: Verification of ...

  13. Confocal microscopy-fracture reconstruction and finite element modeling characterization of local cleavage toughness in a ferritic/martensitic steel in subsized Charpy V-notch impact tests

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, T. E-mail: yamataku@fusion.imr.tohoku.ac.jp; Odette, G.R.; Lucas, G.E.; Matsui, H

    2000-12-01

    The confocal microscopy (CM)-fracture reconstruction (FR) method, coupled with scanning electron microscopy (SEM) fractography, was used to measure the critical notch deformation conditions at cleavage initiation for two subsized Charpy V-notch (CVN) specimen geometries of Japan ferritic/martensitic steel (JFMS). A new method was developed to permit FR of notched specimens. Three-dimensional finite element analysis (FEA) simulations of the notch and specimen deformation were used to estimate values of critical micro-cleavage fracture stress, {sigma}{sup *}, and critical stressed area, A{sup *}. Since {sigma}{sup *}-A{sup *} is independent of size and geometry, it provides a fundamental local measure of cleavage toughness.

  14. V-Notched Bar Creep Life Prediction: GH3536 Ni-Based Superalloy Under Multiaxial Stress State

    Science.gov (United States)

    Zhang, D. X.; Wang, J. P.; Wen, Z. X.; Liu, D. S.; Yue, Z. F.

    2016-07-01

    In this study, creep experiments on smooth and circumferential V-type notched round bars were conducted in GH3536 Ni-based superalloy at 750 °C to identify notch strengthening effect in notched specimens. FE analysis was carried out, coupled with continuum damage mechanics (CDM), to analyze stress distribution and damage evolution under multiaxial stress state. The creep deformation of smooth specimens and the rupture life of both smooth and notched specimens showed good agreement between experimental results and FE analysis predictions; the creep rupture life for the notched specimen was successfully predicted via the "skeletal point" concept. Both creep damage analysis and the observed fracture morphology suggest that creep rupture started first at the root in the V-type notched specimens, and shifted to the region close to the notch root when the notch was relatively shallow compared to U-type notched specimens.

  15. Astronomy Diagnostic Test Results Reflect Course Goals and Show Room for Improvement

    Science.gov (United States)

    LoPresto, Michael C.

    2007-01-01

    The results of administering the Astronomy Diagnostic Test (ADT) to introductory astronomy students at Henry Ford Community College over three years have shown gains comparable with national averages. Results have also accurately corresponded to course goals, showing greater gains in topics covered in more detail, and lower gains in topics covered…

  16. Gun shows and gun violence: fatally flawed study yields misleading results.

    Science.gov (United States)

    Wintemute, Garen J; Hemenway, David; Webster, Daniel; Pierce, Glenn; Braga, Anthony A

    2010-10-01

    A widely publicized but unpublished study of the relationship between gun shows and gun violence is being cited in debates about the regulation of gun shows and gun commerce. We believe the study is fatally flawed. A working paper entitled "The Effect of Gun Shows on Gun-Related Deaths: Evidence from California and Texas" outlined this study, which found no association between gun shows and gun-related deaths. We believe the study reflects a limited understanding of gun shows and gun markets and is not statistically powered to detect even an implausibly large effect of gun shows on gun violence. In addition, the research contains serious ascertainment and classification errors, produces results that are sensitive to minor specification changes in key variables and in some cases have no face validity, and is contradicted by 1 of its own authors' prior research. The study should not be used as evidence in formulating gun policy.

  17. Dynamic Toughness Testing of Pre-Cracked Charpy V-Notch Specimens. Convention ELECTRABEL - SCK-CEN

    Energy Technology Data Exchange (ETDEWEB)

    Lucon, E

    1999-04-01

    This document describes the experimental and analytical procedures which have been adopted at the laboratories of the Belgian Nuclear Research Centre SCK-CEN for performing dynamic toughness tests on pre-cracked Charpy-V specimens. Such procedures were chosen on the basis of the existing literature on the subject, with several updates in the data analysis stages which reflect more recent developments in fracture toughness testing. Qualification tests have been carried out on PCCv specimens of JRQ steel, in order to assess the reliability of the results obtained; straightforward comparisons with reference data have been performed, as well as more advanced analyses using the Master Curve approach. Aspects related to machine compliance and dynamic tup calibration have also been addressed.

  18. Certification of Charpy V-Notch Reference Test Pieces of 30 J Nominal Absorbed Energy - Certified Reference Materials ERM®-FA013bg and ERM®-FA013bh

    OpenAIRE

    LAMBERTY MARIE ANDREE; Dean, Alan; Roebben, Gert

    2011-01-01

    This certification report describes the processing and characterisation of ERM®-FA013bg and ERM®-FA013bh, two batches of Charpy V-notch certified reference test pieces. Sets of five of these test pieces are used for the verification of pendulum impact test machines according to EN 10045-2 (Charpy impact test on metallic materials, Part 2. Method for the verification of impact testing machines [1]) or according to ISO 148-2 (Metallic materials - Charpy pendulum impact test - Part 2: Verificati...

  19. Comparison of some results of program SHOW with other solar hot water computer programs

    Science.gov (United States)

    Young, M. F.; Baughn, J. W.

    Subroutines and the driver program for the simulation code SHOW (solar hot water) for solar thermosyphon systems are discussed, and simulations are compared with predictions by the F-CHART and TRNSYS codes. SHOW has the driver program MAIN, which defines the system control logic for choosing the appropriate system subroutine for analysis. Ten subroutines are described, which account for the solar system physical parameters, the weather data, the manufacturer-supplied system specifications, mass flow rates, pumped systems, total transformed radiation, load use profiles, stratification in storage, an electric water heater, and economic analyses. The three programs are employed to analyze a thermosiphon installation in Sacramento with two storage tanks. TRNSYS and SHOW were in agreement and lower than F-CHARt for annual predictions, although significantly more computer time was necessary to make TRNSYS converge.

  20. Results From Mars Show Electrostatic Charging of the Mars Pathfinder Sojourner Rover

    Science.gov (United States)

    Kolecki, Joseph C.; Siebert, Mark W.

    1998-01-01

    Indirect evidence (dust accumulation) has been obtained indicating that the Mars Pathfinder rover, Sojourner, experienced electrostatic charging on Mars. Lander camera images of the Sojourner rover provide distinctive evidence of dust accumulation on rover wheels during traverses, turns, and crabbing maneuvers. The sol 22 (22nd Martian "day" after Pathfinder landed) end-of-day image clearly shows fine red dust concentrated around the wheel edges with additional accumulation in the wheel hubs. A sol 41 image of the rover near the rock "Wedge" (see the next image) shows a more uniform coating of dust on the wheel drive surfaces with accumulation in the hubs similar to that in the previous image. In the sol 41 image, note particularly the loss of black-white contrast on the Wheel Abrasion Experiment strips (center wheel). This loss of contrast was also seen when dust accumulated on test wheels in the laboratory. We believe that this accumulation occurred because the Martian surface dust consists of clay-sized particles, similar to those detected by Viking, which have become electrically charged. By adhering to the wheels, the charged dust carries a net nonzero charge to the rover, raising its electrical potential relative to its surroundings. Similar charging behavior was routinely observed in an experimental facility at the NASA Lewis Research Center, where a Sojourner wheel was driven in a simulated Martian surface environment. There, as the wheel moved and accumulated dust (see the following image), electrical potentials in excess of 100 V (relative to the chamber ground) were detected by a capacitively coupled electrostatic probe located 4 mm from the wheel surface. The measured wheel capacitance was approximately 80 picofarads (pF), and the calculated charge, 8 x 10(exp -9) coulombs (C). Voltage differences of 100 V and greater are believed sufficient to produce Paschen electrical discharge in the Martian atmosphere. With an accumulated net charge of 8 x 10(exp

  1. Data for behavioral results and brain regions showing a time effect during pair-association retrieval

    Directory of Open Access Journals (Sweden)

    Koji Jimura

    2016-09-01

    Full Text Available The current data article provides behavioral and neuroimaging data for the research article "Relatedness-dependent rapid development of brain activity in anterior temporal cortex during pair-association retrieval” (Jimura et al., 2016 [1]. Behavioral performance is provided in a table. Fig. 2 of the article is based on this table. Brain regions showing time effect are provided in a table. A statistical activation map for the time effect is shown in Fig. 3C of the article.

  2. Animation shows promise in initiating timely cardiopulmonary resuscitation: results of a pilot study.

    Science.gov (United States)

    Attin, Mina; Winslow, Katheryn; Smith, Tyler

    2014-04-01

    Delayed responses during cardiac arrest are common. Timely interventions during cardiac arrest have a direct impact on patient survival. Integration of technology in nursing education is crucial to enhance teaching effectiveness. The goal of this study was to investigate the effect of animation on nursing students' response time to cardiac arrest, including initiation of timely chest compression. Nursing students were randomized into experimental and control groups prior to practicing in a high-fidelity simulation laboratory. The experimental group was educated, by discussion and animation, about the importance of starting cardiopulmonary resuscitation upon recognizing an unresponsive patient. Afterward, a discussion session allowed students in the experimental group to gain more in-depth knowledge about the most recent changes in the cardiac resuscitation guidelines from the American Heart Association. A linear mixed model was run to investigate differences in time of response between the experimental and control groups while controlling for differences in those with additional degrees, prior code experience, and basic life support certification. The experimental group had a faster response time compared with the control group and initiated timely cardiopulmonary resuscitation upon recognition of deteriorating conditions (P < .0001). The results demonstrated the efficacy of combined teaching modalities for timely cardiopulmonary resuscitation. Providing opportunities for repetitious practice when a patient's condition is deteriorating is crucial for teaching safe practice.

  3. FES Training in Aging: interim results show statistically significant improvements in mobility and muscle fiber size

    Directory of Open Access Journals (Sweden)

    Helmut Kern

    2012-03-01

    Full Text Available Aging is a multifactorial process that is characterized by decline in muscle mass and performance. Several factors, including reduced exercise, poor nutrition and modified hormonal metabolism, are responsible for changes in the rates of protein synthesis and degradation that drive skeletal muscle mass reduction with a consequent decline of force generation and mobility functional performances. Seniors with normal life style were enrolled: two groups in Vienna (n=32 and two groups in Bratislava: (n=19. All subjects were healthy and declared not to have any specific physical/disease problems. The two Vienna groups of seniors exercised for 10 weeks with two different types of training (leg press at the hospital or home-based functional electrical stimulation, h-b FES. Demografic data (age, height and weight were recorded before and after the training period and before and after the training period the patients were submitted to mobility functional analyses and muscle biopsies. The mobility functional analyses were: 1. gait speed (10m test fastest speed, in m/s; 2. time which the subject needed to rise from a chair for five times (5x Chair-Rise, in s; 3. Timed –Up-Go- Test, in s; 4. Stair-Test, in s; 5. isometric measurement of quadriceps force (Torque/kg, in Nm/kg; and 6. Dynamic Balance in mm. Preliminary analyses of muscle biopsies from quadriceps in some of the Vienna and Bratislava patients present morphometric results consistent with their functional behaviors. The statistically significant improvements in functional testings here reported demonstrates the effectiveness of h-b FES, and strongly support h-b FES, as a safe home-based method to improve contractility and performances of ageing muscles.

  4. An Investigation on the Wear Resistance and Fatigue Behaviour of Ti-6Al-4V Notched Members Coated with Hydroxyapatite Coatings

    Directory of Open Access Journals (Sweden)

    Reza H Oskouei

    2016-02-01

    Full Text Available In this study, surface properties of Ti-6Al-4V alloy coated with hydroxyapatite coatings were investigated. Wear resistance and fatigue behaviour of samples with coating thicknesses of 10 and 50 µm as well as uncoated samples were examined. Wear experiments demonstrated that the friction factor of the uncoated titanium decreased from 0.31 to 0.06, through a fluctuating trend, after 50 cycles of wear tests. However, the friction factor of both the coated samples (10 and 50 µm gradually decreased from 0.20 to 0.12 after 50 cycles. At the end of the 50th cycle, the penetration depth of the 10 and 50 µm coated samples were 7.69 and 6.06 µm, respectively. Fatigue tests showed that hydroxyapatite coatings could improve fatigue life of a notched Ti-6Al-4V member in both low and high cycle fatigue zones. It was understood, from fractography of the fracture surfaces, that the fatigue zone of the uncoated specimens was generally smaller in comparison with that of the coated specimens. No significant difference was observed between the fatigue life of coated specimens with 10 and 50 µm thicknesses.

  5. Reception of Talent Shows in Denmark: First Results from a Trans-National Audience Study of a Global Format Genre

    DEFF Research Database (Denmark)

    Jensen, Pia Majbritt

    This paper will discuss the methodology and present the preliminary findings of the Danish part of a trans-national, comparative audience study of the musical talent show genre undertaken in Denmark, Finland, Germany and Great Britain in Spring 2013. Within the international business model...... of format adaptation, the musical talent show genre has been particularly successful in crossing cultural borders. Formats such as Idols, X Factor and Voice have sold to a large variety of countries, covering all continents. Such global reach inevitably raises the question of the genre’s audience appeal...... that television formats to a considerable degree are adapted according to national audiences and, hence, national cultural tastes. And in our research approach, we do recognize that musical talent shows appear to contribute to ‘imagining the nation’ (Anderson 1983), often even mentioning the nation in the title...

  6. Early Results Show Reduced Infection Rate Using No-touch Technique for Expander/ADM Breast Reconstruction

    OpenAIRE

    Henry B. Wilson, MD, FACS

    2015-01-01

    Summary: Infection is a common complication of immediate breast reconstruction that often leads to device removal, a result emotionally devastating to the patient and frustrating for her surgeon. “No-touch” techniques have been used in other surgical disciplines and plastic surgery, but they have not been reported for breast reconstruction with tissue expanders or implants and acellular dermis. We report a novel technique of tissue expander and acellular dermis placement using no-touch princi...

  7. Early Results Show Reduced Infection Rate Using No-touch Technique for Expander/ADM Breast Reconstruction

    Directory of Open Access Journals (Sweden)

    Henry B. Wilson, MD, FACS

    2015-03-01

    Full Text Available Summary: Infection is a common complication of immediate breast reconstruction that often leads to device removal, a result emotionally devastating to the patient and frustrating for her surgeon. “No-touch” techniques have been used in other surgical disciplines and plastic surgery, but they have not been reported for breast reconstruction with tissue expanders or implants and acellular dermis. We report a novel technique of tissue expander and acellular dermis placement using no-touch principles with a self-retaining retractor system that holds promise to decrease infectious complications of breast reconstruction.

  8. Low-frequency ac electroporation shows strong frequency dependence and yields comparable transfection results to dc electroporation.

    Science.gov (United States)

    Zhan, Yihong; Cao, Zhenning; Bao, Ning; Li, Jianbo; Wang, Jun; Geng, Tao; Lin, Hao; Lu, Chang

    2012-06-28

    Conventional electroporation has been conducted by employing short direct current (dc) pulses for delivery of macromolecules such as DNA into cells. The use of alternating current (ac) field for electroporation has mostly been explored in the frequency range of 10kHz-1MHz. Based on Schwan equation, it was thought that with low ac frequencies (10Hz-10kHz), the transmembrane potential does not vary with the frequency. In this report, we utilized a flow-through electroporation technique that employed continuous 10Hz-10kHz ac field (based on either sine waves or square waves) for electroporation of cells with defined duration and intensity. Our results reveal that electropermeabilization becomes weaker with increased frequency in this range. In contrast, transfection efficiency with DNA reaches its maximum at medium frequencies (100-1000Hz) in the range. We postulate that the relationship between the transfection efficiency and the ac frequency is determined by combined effects from electrophoretic movement of DNA in the ac field, dependence of the DNA/membrane interaction on the ac frequency, and variation of transfection under different electropermeabilization intensities. The fact that ac electroporation in this frequency range yields high efficiency for transfection (up to ~71% for Chinese hamster ovary cells) and permeabilization suggests its potential for gene delivery.

  9. Selection Indices and Multivariate Analysis Show Similar Results in the Evaluation of Growth and Carcass Traits in Beef Cattle.

    Directory of Open Access Journals (Sweden)

    Fernando Brito Lopes

    Full Text Available This research evaluated a multivariate approach as an alternative tool for the purpose of selection regarding expected progeny differences (EPDs. Data were fitted using a multi-trait model and consisted of growth traits (birth weight and weights at 120, 210, 365 and 450 days of age and carcass traits (longissimus muscle area (LMA, back-fat thickness (BF, and rump fat thickness (RF, registered over 21 years in extensive breeding systems of Polled Nellore cattle in Brazil. Multivariate analyses were performed using standardized (zero mean and unit variance EPDs. The k mean method revealed that the best fit of data occurred using three clusters (k = 3 (P < 0.001. Estimates of genetic correlation among growth and carcass traits and the estimates of heritability were moderate to high, suggesting that a correlated response approach is suitable for practical decision making. Estimates of correlation between selection indices and the multivariate index (LD1 were moderate to high, ranging from 0.48 to 0.97. This reveals that both types of indices give similar results and that the multivariate approach is reliable for the purpose of selection. The alternative tool seems very handy when economic weights are not available or in cases where more rapid identification of the best animals is desired. Interestingly, multivariate analysis allowed forecasting information based on the relationships among breeding values (EPDs. Also, it enabled fine discrimination, rapid data summarization after genetic evaluation, and permitted accounting for maternal ability and the genetic direct potential of the animals. In addition, we recommend the use of longissimus muscle area and subcutaneous fat thickness as selection criteria, to allow estimation of breeding values before the first mating season in order to accelerate the response to individual selection.

  10. Snobbish Show

    Institute of Scientific and Technical Information of China (English)

    YIN PUMIN

    2010-01-01

    @@ The State Administration of Radio,Film and Television (SARFT),China's media watchdog,issued a new set of mles on June 9 that strictly regulate TV match-making shows,which have been sweeping the country's primetime programming. "Improper social and love values such as money worship should not be presented in these shows.Humiliation,verbal attacks and sex-implied vulgar content are not allowed" the new roles said.

  11. Show Time

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Story: Show Time!The whole class presents the story"Under the Sea".Everyone is so excited and happy.Both Leo and Kathy show their parentsthe characters of the play."Who’s he?"asks Kathy’s mom."He’s the prince."Kathy replies."Who’s she?"asks Leo’s dad."She’s the queen."Leo replieswith a smile.

  12. EROBATIC SHOW

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    Visitors look at plane models of the Commercial Aircraft Corp. of China, developer of the count,s first homegrown large passenger jet C919, during the Singapore Airshow on February 16. The biennial event is the largest airshow in Asia and one of the most important aviation and defense shows worldwide. A number of Chinese companies took part in the event during which Okay Airways, the first privately owned aidine in China, signed a deal to acquire 12 Boeing 737 jets.

  13. Results of crack-arrest tests on two irradiated high-copper welds

    Energy Technology Data Exchange (ETDEWEB)

    Iskander, S.K.; Corwin, W.R.; Nanstead, R.K. (Oak Ridge National Lab., TN (USA))

    1990-12-01

    The objective of this study was to determine the effect of neutron irradiation on the shift and shape of the lower-bound curve to crack-arrest data. Two submerged-arc welds with copper contents of 0.23 and 0.31 wt % were commercially fabricated in 220-mm-thick plate. Crack-arrest specimens fabricated from these welds were irradiated at a nominal temperature of 288{degree}C to an average fluence of 1.9 {times} 10{sup 19} neutrons/cm{sup 2} (>1 MeV). Evaluation of the results shows that the neutron-irradiation-induced crack-arrest toughness temperature shift is about the same as the Charpy V-notch impact temperature shift at the 41-J energy level. The shape of the lower-bound curves (for the range of test temperatures covered) did not seem to have been altered by irradiation compared to those of the ASME K{sub Ia} curve. 9 refs., 21 figs., 10 tabs.

  14. Analysis of conservative tracer measurement results using the Frechet distribution at planted horizontal subsurface flow constructed wetlands filled with coarse gravel and showing the effect of clogging processes.

    Science.gov (United States)

    Dittrich, Ernő; Klincsik, Mihály

    2015-11-01

    A mathematical process, developed in Maple environment, has been successful in decreasing the error of measurement results and in the precise calculation of the moments of corrected tracer functions. It was proved that with this process, the measured tracer results of horizontal subsurface flow constructed wetlands filled with coarse gravel (HSFCW-C) can be fitted more accurately than with the conventionally used distribution functions (Gaussian, Lognormal, Fick (Inverse Gaussian) and Gamma). This statement is true only for the planted HSFCW-Cs. The analysis of unplanted HSFCW-Cs needs more research. The result of the analysis shows that the conventional solutions (completely stirred series tank reactor (CSTR) model and convection-dispersion transport (CDT) model) cannot describe these types of transport processes with sufficient accuracy. These outcomes can help in developing better process descriptions of very difficult transport processes in HSFCW-Cs. Furthermore, a new mathematical process can be developed for the calculation of real hydraulic residence time (HRT) and dispersion coefficient values. The presented method can be generalized to other kinds of hydraulic environments.

  15. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects

    DEFF Research Database (Denmark)

    Strandgren, Charlotte; Nasser, Hasina Abdul; McKenna, Tomás;

    2015-01-01

    model to study the possibility of recovering from HGPS bone disease upon silencing of the HGPS mutation, and the potential benefits from treatment with resveratrol. We show that complete silencing of the transgenic expression of progerin normalized bone morphology and mineralization already after 7...... weeks. The improvements included lower frequencies of rib fractures and callus formation, an increased number of osteocytes in remodeled bone, and normalized dentinogenesis. The beneficial effects from resveratrol treatment were less significant and to a large extent similar to mice treated with sucrose...... alone. However, the reversal of the dental phenotype of overgrown and laterally displaced lower incisors in HGPS mice could be attributed to resveratrol. Our results indicate that the HGPS bone defects were reversible upon suppressed transgenic expression and suggest that treatments targeting aberrant...

  16. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects.

    Science.gov (United States)

    Strandgren, Charlotte; Nasser, Hasina Abdul; McKenna, Tomás; Koskela, Antti; Tuukkanen, Juha; Ohlsson, Claes; Rozell, Björn; Eriksson, Maria

    2015-08-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that is most commonly caused by a de novo point mutation in exon 11 of the LMNA gene, c.1824C>T, which results in an increased production of a truncated form of lamin A known as progerin. In this study, we used a mouse model to study the possibility of recovering from HGPS bone disease upon silencing of the HGPS mutation, and the potential benefits from treatment with resveratrol. We show that complete silencing of the transgenic expression of progerin normalized bone morphology and mineralization already after 7 weeks. The improvements included lower frequencies of rib fractures and callus formation, an increased number of osteocytes in remodeled bone, and normalized dentinogenesis. The beneficial effects from resveratrol treatment were less significant and to a large extent similar to mice treated with sucrose alone. However, the reversal of the dental phenotype of overgrown and laterally displaced lower incisors in HGPS mice could be attributed to resveratrol. Our results indicate that the HGPS bone defects were reversible upon suppressed transgenic expression and suggest that treatments targeting aberrant progerin splicing give hope to patients who are affected by HGPS.

  17. Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem proteinopathy.

    Directory of Open Access Journals (Sweden)

    Angèle Nalbandian

    Full Text Available Mutations in the valosin containing protein (VCP gene cause hereditary Inclusion body myopathy (hIBM associated with Paget disease of bone (PDB, frontotemporal dementia (FTD, more recently termed multisystem proteinopathy (MSP. Affected individuals exhibit scapular winging and die from progressive muscle weakness, and cardiac and respiratory failure, typically in their 40s to 50s. Histologically, patients show the presence of rimmed vacuoles and TAR DNA-binding protein 43 (TDP-43-positive large ubiquitinated inclusion bodies in the muscles. We have generated a VCPR155H/+ mouse model which recapitulates the disease phenotype and impaired autophagy typically observed in patients with VCP disease. Autophagy-modifying agents, such as rapamycin and chloroquine, at pharmacological doses have previously shown to alter the autophagic flux. Herein, we report results of administration of rapamycin, a specific inhibitor of the mechanistic target of rapamycin (mTOR signaling pathway, and chloroquine, a lysosomal inhibitor which reverses autophagy by accumulating in lysosomes, responsible for blocking autophagy in 20-month old VCPR155H/+ mice. Rapamycin-treated mice demonstrated significant improvement in muscle performance, quadriceps histological analysis, and rescue of ubiquitin, and TDP-43 pathology and defective autophagy as indicated by decreased protein expression levels of LC3-I/II, p62/SQSTM1, optineurin and inhibiting the mTORC1 substrates. Conversely, chloroquine-treated VCPR155H/+ mice revealed progressive muscle weakness, cytoplasmic accumulation of TDP-43, ubiquitin-positive inclusion bodies and increased LC3-I/II, p62/SQSTM1, and optineurin expression levels. Our in vitro patient myoblasts studies treated with rapamycin demonstrated an overall improvement in the autophagy markers. Targeting the mTOR pathway ameliorates an increasing list of disorders, and these findings suggest that VCP disease and related neurodegenerative multisystem

  18. Storytelling Slide Shows to Improve Diabetes and High Blood Pressure Knowledge and Self-Efficacy: Three-Year Results among Community Dwelling Older African Americans

    Science.gov (United States)

    Bertera, Elizabeth M.

    2014-01-01

    This study combined the African American tradition of oral storytelling with the Hispanic medium of "Fotonovelas." A staggered pretest posttest control group design was used to evaluate four Storytelling Slide Shows on health that featured community members. A total of 212 participants were recruited for the intervention and 217 for the…

  19. Showing results? An analysis of the perceptions of internal and external stakeholders of the public performance communication by the Belgian and Dutch Railways

    NARCIS (Netherlands)

    Gelders, Dave; Galetzka, Mirjam; Verckens, Jan Pieter; Seydel, Erwin

    2008-01-01

    Information Quarterly, 15: 153–156). In Belgium and the Netherlands, one Performance measurement and communicating about it with the broader public is not self-evident if one looks at public services organizations (Hernon, 1998 P. Hernon, The government performance and results act. Government Inform

  20. The relevance of external quality assessment for molecular testing for ALK positive non-small cell lung cancer: results from two pilot rounds show room for optimization.

    Directory of Open Access Journals (Sweden)

    Lien Tembuyser

    Full Text Available Molecular profiling should be performed on all advanced non-small cell lung cancer with non-squamous histology to allow treatment selection. Currently, this should include EGFR mutation testing and testing for ALK rearrangements. ROS1 is another emerging target. ALK rearrangement status is a critical biomarker to predict response to tyrosine kinase inhibitors such as crizotinib. To promote high quality testing in non-small cell lung cancer, the European Society of Pathology has introduced an external quality assessment scheme. This article summarizes the results of the first two pilot rounds organized in 2012-2013.Tissue microarray slides consisting of cell-lines and resection specimens were distributed with the request for routine ALK testing using IHC or FISH. Participation in ALK FISH testing included the interpretation of four digital FISH images.Data from 173 different laboratories was obtained. Results demonstrate decreased error rates in the second round for both ALK FISH and ALK IHC, although the error rates were still high and the need for external quality assessment in laboratories performing ALK testing is evident. Error rates obtained by FISH were lower than by IHC. The lowest error rates were observed for the interpretation of digital FISH images.There was a large variety in FISH enumeration practices. Based on the results from this study, recommendations for the methodology, analysis, interpretation and result reporting were issued. External quality assessment is a crucial element to improve the quality of molecular testing.

  1. Cells exposed to a huntingtin fragment containing an expanded polyglutamine tract show no sign of ion channel formation: results arguing against the ion channel hypothesis

    DEFF Research Database (Denmark)

    Nørremølle, Anne; Grunnet, Morten; Hasholt, Lis

    2003-01-01

    Ion channels formed by expanded polyglutamine tracts have been proposed to play an important role in the pathological processes leading to neurodegeneration in Huntington's disease and other CAG repeat diseases. We tested the capacity of a huntingtin fragment containing an expanded polyglutamine ...... in the currents recorded in any of the two expression systems, indicating no changes in ion channel activity. The results therefore argue against the proposed hypothesis of expanded polyglutamines forming ion channels....

  2. Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients.

    Science.gov (United States)

    Kresty, Laura A; Frankel, Wendy L; Hammond, Cynthia D; Baird, Maureen E; Mele, Jennifer M; Stoner, Gary D; Fromkes, John J

    2006-01-01

    Increased fruit and vegetable consumption is associated with decreased risk of a number of cancers of epithelial origin, including esophageal cancer. Dietary administration of lyophilized black raspberries (LBRs) has significantly inhibited chemically induced oral, esophageal, and colon carcinogenesis in animal models. Likewise, berry extracts added to cell cultures significantly inhibited cancer-associated processes. Positive results in preclinical studies have supported further investigation of berries and berry extracts in high-risk human cohorts, including patients with existing premalignancy or patients at risk for cancer recurrence. We are currently conducting a 6-mo chemopreventive pilot study administering 32 or 45 g (female and male, respectively) of LBRs to patients with Barrett's esophagus (BE), a premalignant esophageal condition in which the normal stratified squamous epithelium changes to a metaplastic columnar-lined epithelium. BE's importance lies in the fact that it confers a 30- to 40-fold increased risk for the development of esophageal adenocarcinoma, a rapidly increasing and extremely deadly malignancy. This is a report on interim findings from 10 patients. To date, the results support that daily consumption of LBRs promotes reductions in the urinary excretion of two markers of oxidative stress, 8-epi-prostaglandin F2alpha (8-Iso-PGF2) and, to a lesser more-variable extent, 8-hydroxy-2'-deoxyguanosine (8-OHdG), among patients with BE.

  3. The Use of Online Pre-Lab Assessments Compared with Written Pre-Lab Assignments Requiring Experimental Result Prediction Shows No Difference in Student Performance

    Directory of Open Access Journals (Sweden)

    Erica L. Suchman

    2015-08-01

    Full Text Available Exam performance was compared for students who hand wrote questions designed to prepare them for daily lab activities in a senior level virology laboratory course versus those who answered questions created to mirror the written questions on-line.  No significant difference was noted in exam scores on any of the three midterms, written final exam, nor the practical exam.  Neither was there a significant difference in the quality of the laboratory reports turned in as evidenced by similar average scores over four years.  These results indicate that using online pre-labs to prepare students for the laboratory sessions leads to equivalent learning as answering handwritten pre-lab assignments.  Online pre-labs significantly reduced the amount of grading without reducing student learning, allowing a reduction in the number of teaching assistants required per section.

  4. In axial spondyloarthritis, never smokers, ex-smokers and current smokers show a gradient of increasing disease severity - results from the Scotland Registry for Ankylosing Spondylitis (SIRAS).

    Science.gov (United States)

    Jones, Gareth T; Ratz, Tiara; Dean, Linda E; Macfarlane, Gary J; Atzeni, Fabiola

    2016-11-29

    Objectives To examine the relationship between smoking, smoking cessation, and disease characteristics/quality of life (QoL) in spondyloarthritis. Methods The Scotland Registry for Ankylosing Spondylitis collects data from clinically diagnosed patients with spondyloarthritis. Clinical data, including Bath Ankylosing Spondylitis indices of disease activity (BASDAI) and function (BASFI), was obtained from medical records. Postal questionnaires provided information on smoking status and QoL (Ankylosing Spondylitis QoL questionnaire; ASQoL). Linear and logistic regression quantified the effect of smoking, and smoking cessation, on various disease-specific and QoL outcomes, adjusting for age, sex, deprivation, education and alcohol status. Results are presented as regression coefficients (β) or odds ratios (OR) with 95% confidence intervals. Results 946 participants provided data (male 73.5%, mean age 52yrs). Current smoking was reported by 22%, and 38% were ex-smokers. Ever smokers experienced poorer BASDAI (β = 0.5; 0.2 to 0.9) and BASFI (β = 0.8; 0.4 to 1.2), and reported worse QoL (ASQoL, β = 1.5; 0.7 to 2.3). Compared to current smokers, ex-smokers reported lower disease activity (BASDAI, β = -0.5; -1.0 to -0.04) and significantly better QoL (ASQoL, β = -1.2; -2.3 to -0.2). They also were more likely to have a uveitis history (OR = 2.4; 1.5 to 3.8). Conclusions Smokers with spondyloarthritis experience worse disease than never smokers. However, we provide new evidence that, among smokers, smoking cessation is associated with lower disease activity and better physical function and QoL. Clinicians should specifically promote smoking cessation as an adjunct to usual therapy in patients with spondyloarthritis. This article is protected by copyright. All rights reserved.

  5. Value of Fused 18F-Choline-PET/MRI to Evaluate Prostate Cancer Relapse in Patients Showing Biochemical Recurrence after EBRT: Preliminary Results

    Directory of Open Access Journals (Sweden)

    Arnoldo Piccardo

    2014-01-01

    Full Text Available Purpose. We compared the accuracy of 18F-Choline-PET/MRI with that of multiparametric MRI (mMRI, 18F-Choline-PET/CT, 18F-Fluoride-PET/CT, and contrast-enhanced CT (CeCT in detecting relapse in patients with suspected relapse of prostate cancer (PC after external beam radiotherapy (EBRT. We assessed the association between standard uptake value (SUV and apparent diffusion coefficient (ADC. Methods. We evaluated 21 patients with biochemical relapse after EBRT. Patients underwent 18F-Choline-PET/contrast-enhanced (CeCT, 18F-Fluoride-PET/CT, and mMRI. Imaging coregistration of PET and mMRI was performed. Results. 18F-Choline-PET/MRI was positive in 18/21 patients, with a detection rate (DR of 86%. DRs of 18F-Choline-PET/CT, CeCT, and mMRI were 76%, 43%, and 81%, respectively. In terms of DR the only significant difference was between 18F-Choline-PET/MRI and CeCT. On lesion-based analysis, the accuracy of 18F-Choline-PET/MRI, 18F-Choline-PET/CT, CeCT, and mMRI was 99%, 95%, 70%, and 85%, respectively. Accuracy, sensitivity, and NPV of 18F-Choline-PET/MRI were significantly higher than those of both mMRI and CeCT. On whole-body assessment of bone metastases, the sensitivity of 18F-Choline-PET/CT and 18F-Fluoride-PET/CT was significantly higher than that of CeCT. Regarding local and lymph node relapse, we found a significant inverse correlation between ADC and SUV-max. Conclusion. 18F-Choline-PET/MRI is a promising technique in detecting PC relapse.

  6. Violence and TV Shows

    OpenAIRE

    ÖZTÜRK, Yrd. Doç. Dr. Şinasi

    2008-01-01

    This study aims to discuss theories on theviolent effects of TV shows on viewers, especiallyon children. Therefore, this study includes a briefdiscussion of definitions of violence, discussionof violence theories, main results of researcheson televised violence, measuring TV violence,perception of televised violence, individualdifferences and reactions to TV violence,aggressiveness and preferences for TV violence.

  7. Public medical shows.

    Science.gov (United States)

    Walusinski, Olivier

    2014-01-01

    In the second half of the 19th century, Jean-Martin Charcot (1825-1893) became famous for the quality of his teaching and his innovative neurological discoveries, bringing many French and foreign students to Paris. A hunger for recognition, together with progressive and anticlerical ideals, led Charcot to invite writers, journalists, and politicians to his lessons, during which he presented the results of his work on hysteria. These events became public performances, for which physicians and patients were transformed into actors. Major newspapers ran accounts of these consultations, more like theatrical shows in some respects. The resultant enthusiasm prompted other physicians in Paris and throughout France to try and imitate them. We will compare the form and substance of Charcot's lessons with those given by Jules-Bernard Luys (1828-1897), Victor Dumontpallier (1826-1899), Ambroise-Auguste Liébault (1823-1904), Hippolyte Bernheim (1840-1919), Joseph Grasset (1849-1918), and Albert Pitres (1848-1928). We will also note their impact on contemporary cinema and theatre.

  8. The Great Cometary Show

    Science.gov (United States)

    2007-01-01

    The ESO Very Large Telescope Interferometer, which allows astronomers to scrutinise objects with a precision equivalent to that of a 130-m telescope, is proving itself an unequalled success every day. One of the latest instruments installed, AMBER, has led to a flurry of scientific results, an anthology of which is being published this week as special features in the research journal Astronomy & Astrophysics. ESO PR Photo 06a/07 ESO PR Photo 06a/07 The AMBER Instrument "With its unique capabilities, the VLT Interferometer (VLTI) has created itself a niche in which it provide answers to many astronomical questions, from the shape of stars, to discs around stars, to the surroundings of the supermassive black holes in active galaxies," says Jorge Melnick (ESO), the VLT Project Scientist. The VLTI has led to 55 scientific papers already and is in fact producing more than half of the interferometric results worldwide. "With the capability of AMBER to combine up to three of the 8.2-m VLT Unit Telescopes, we can really achieve what nobody else can do," added Fabien Malbet, from the LAOG (France) and the AMBER Project Scientist. Eleven articles will appear this week in Astronomy & Astrophysics' special AMBER section. Three of them describe the unique instrument, while the other eight reveal completely new results about the early and late stages in the life of stars. ESO PR Photo 06b/07 ESO PR Photo 06b/07 The Inner Winds of Eta Carinae The first results presented in this issue cover various fields of stellar and circumstellar physics. Two papers deal with very young solar-like stars, offering new information about the geometry of the surrounding discs and associated outflowing winds. Other articles are devoted to the study of hot active stars of particular interest: Alpha Arae, Kappa Canis Majoris, and CPD -57o2874. They provide new, precise information about their rotating gas envelopes. An important new result concerns the enigmatic object Eta Carinae. Using AMBER with

  9. Showing Value (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2009-06-01

    librarians on student achievement. Todd notes, “If we do not show value, we will not have a future. Evidence-based practice is not about the survival of school librarians, it’s about the survival of our students” (40. In this issue we feature school libraries and their connection to evidence based practice. Former Editor-in-Chief, Lindsay Glynn, began putting the wheels in motion for this feature almost a year ago. She invited Carol Gordon and Ross Todd to act as guest editors of the section, drawing upon their contacts and previous work in this field. The result is an issue with five feature articles exploring different aspects of the connection between school libraries and evidence based practice, from the theoretical to the practical. In addition, there is a thought-provoking Commentary by David Loertscher, asking whether we need the evolutionary model of evidence based practice, or something more revolutionary!In addition to the Feature section, we have a well-rounded issue with articles on the topics of library human resources, and the development of a scholars’ portal. As well, there are a record 10 evidence summaries and our educational EBL101 column. I hope there is something for everyone in this issue of EBLIP – enjoy, and see you soon in Stockholm!

  10. Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures

    Directory of Open Access Journals (Sweden)

    Sugawara Kazuo

    2001-10-01

    Full Text Available Abstract Background Since Fuchs' report in 1999, the reported protective effect of dietary fiber from colorectal carcinogenesis has led many researchers to question its real benefit. The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan. Methods A multiple regression analysis (using the stepwise variable selection method was performed using the standardized mortality ratios (SMRs of colon and rectal cancer in 23 Japanese prefectures as objective variables and dietary fiber, nutrients and food groups as explanatory variables. Results As for colon cancer, the standardized partial correlation coefficients were positively significant for fat (1,13, P = 0.000, seaweeds (0.41, P = 0.026 and beans (0.45, P = 0.017 and were negatively significant for vitamin A (-0.63, P = 0.003, vitamin C (-0.42, P = 0.019 and yellow-green vegetables (-0.37, P = 0.046. For rectal cancer, the standardized partial correlation coefficient in fat (0.60, P = 0.002 was positively significant. Dietary fiber was not found to have a significant relationship with either colon or rectal cancers. Conclusions This study failed to show any protective effect of dietary fiber in subjects with a low fat intake (Japanese in this analysis, which supports Fuchs' findings in subjects with a high fat intake (US Americans.

  11. A Fashion Show

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>Story: The yearly fashion show day.The children take turns to walk on the stage and show the class their favorite clothes.Now it’s Joe’s and Phoebe’s turn.Joe walks on the stage and says,“My shorts are blue.Do you like my blue shorts?”On the other side of the stage, Phoebe is wearing her favorite pink skirt.“My skirt is pink.Do you like my pink skirt?”asks

  12. A Visionary Show

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Seduction. Distinction. Relax. Pulsation. These are the "style universes" on display at Première Vision, heralded as "The World’s Premiere Fabric Show." Started more than 35 years ago by 15 French weavers, Première Vision has expanded beyond its

  13. Honored Teacher Shows Commitment.

    Science.gov (United States)

    Ratte, Kathy

    1987-01-01

    Part of the acceptance speech of the 1985 National Council for the Social Studies Teacher of the Year, this article describes the censorship experience of this honored social studies teacher. The incident involved the showing of a videotape version of the feature film entitled "The Seduction of Joe Tynan." (JDH)

  14. Results of crack-arrest tests on irradiated a 508 class 3 steel

    Energy Technology Data Exchange (ETDEWEB)

    Iskander, S.K.; Milella, P.P.; Pini, M.A.

    1998-02-01

    Ten crack-arrest toughness values for irradiated specimens of A 508 class 3 forging steel have been obtained. The tests were performed according to the American Society for Testing and Materials (ASTM) Standard Test Method for Determining Plane-Strain Crack-Arrest Fracture Toughness, K{sub la} of Ferritic Steels, E 1221-88. None of these values are strictly valid in all five ASTM E 1221-88 validity criteria. However, they are useful when compared to unirradiated crack-arrest specimen toughness values since they show the small (averaging approximately 10{degrees}C) shifts in the mean and lower-bound crack-arrest toughness curves. This confirms that a low copper content in ASTM A 508 class 3 forging material can be expected to result in small shifts of the transition toughness curve. The shifts due to neutron irradiation of the lower bound and mean toughness curves are approximately the same as the Charpy V-notch (CVN) 41-J temperature shift. The nine crack-arrest specimens were irradiated at temperatures varying from 243 to 280{degrees}C, and to a fluence varying from 1.7 to 2.7 x 10{sup 19} neutrons/cm{sup 2} (> 1 MeV). The test results were normalized to reference values that correspond to those of CVN specimens irradiated at 284{degrees}C to a fluence of 3.2 x 10{sup 19} neutrons/cm{sup 2} (> 1 MeV) in the same capsule as the crack-arrest specimens. This adjustment resulted in a shift to lower temperatures of all the data, and in particular moved two data points that appeared to lie close to or lower than the American Society of Mechanical Engineers K{sub la} curve to positions that seemed more reasonable with respect to the remaining data. A special fixture was designed, fabricated, and successfully used in the testing. For reasons explained in the text, special blocks to receive the Oak Ridge National Laboratory clip gage were designed, and greater-than-standard crack-mouth opening displacements measured were accounted for. 24 refs., 13 figs., 12 tabs.

  15. Shanghai Shows Its Heart

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The city known as China’s economic powerhouse showed a more caring face as host of the Special Olympic Games Between October 2 and 11,the Special Olympics Summer Games were hosted in Shanghai,the first time the 40-year-old athletic com- petition for people with intellectual disabilities came to a developing country. This Special Olympics was also larger than all previous games in temps of the number of athletes.

  16. Not a "reality" show.

    Science.gov (United States)

    Wrong, Terence; Baumgart, Erica

    2013-01-01

    The authors of the preceding articles raise legitimate questions about patient and staff rights and the unintended consequences of allowing ABC News to film inside teaching hospitals. We explain why we regard their fears as baseless and not supported by what we heard from individuals portrayed in the filming, our decade-long experience making medical documentaries, and the full un-aired context of the scenes shown in the broadcast. The authors don't and can't know what conversations we had, what documents we reviewed, and what protections we put in place in each televised scene. Finally, we hope to correct several misleading examples cited by the authors as well as their offhand mischaracterization of our program as a "reality" show.

  17. In favour of the definition "adolescents with idiopathic scoliosis": juvenile and adolescent idiopathic scoliosis braced after ten years of age, do not show different end results. SOSORT award winner 2014

    OpenAIRE

    Donzelli, Sabrina; Zaina, Fabio; Lusini, Monia; Minnella, Salvatore; Negrini, Stefano

    2014-01-01

    Background The most important factor discriminating juvenile (JIS) from adolescent idiopathic scoliosis (AIS) is the risk of deformity progression. Brace treatment can change natural history, even when risk of progression is high. The aim of this study was to compare the end of growth results of JIS subjects, treated after 10 years of age, with final results of AIS. Methods Design: prospective observational controlled cohort study nested in a prospective database. Setting: outpatient tertiary...

  18. The "Life Potential": a new complex algorithm to assess "Heart Rate Variability" from Holter records for cognitive and diagnostic aims. Preliminary experimental results showing its dependence on age, gender and health conditions

    CERN Document Server

    Barra, Orazio A

    2013-01-01

    Although HRV (Heart Rate Variability) analyses have been carried out for several decades, several limiting factors still make these analyses useless from a clinical point of view. The present paper aims at overcoming some of these limits by introducing the "Life Potential" (BMP), a new mathematical algorithm which seems to exhibit surprising cognitive and predictive capabilities. BMP is defined as a linear combination of five HRV Non-Linear Variables, in turn derived from the thermodynamic formalism of chaotic dynamic systems. The paper presents experimental measurements of BMP (Average Values and Standard Deviations) derived from 1048 Holter tests, matched in age and gender, including a control group of 356 healthy subjects. The main results are: (a) BMP always decreases when the age increases, and its dependence on age and gender is well established; (b) the shape of the age dependence within "healthy people" is different from that found in the general group: this behavior provides evidence of possible illn...

  19. Stem cells show promising results for lymphoedema treatment

    DEFF Research Database (Denmark)

    Toyserkani, Navid Mohamadpour; Quaade, Marlene Louise; Sheikh, Søren Paludan

    2015-01-01

    Abstract Lymphoedema is a debilitating condition, manifesting in excess lymphatic fluid and swelling of subcutaneous tissues. Lymphoedema is as of yet still an incurable condition and current treatment modalities are not satisfactory. The capacity of mesenchymal stem cells to promote angiogenesis......, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types make them a potential ideal therapy for lymphoedema. Adipose tissue is the richest and most accessible source of mesenchymal stem cells and they can be harvested, isolated, and used for therapy...... in a single stage procedure as an autologous treatment. The aim of this paper was to review all studies using mesenchymal stem cells for lymphoedema treatment with a special focus on the potential use of adipose-derived stem cells. A systematic search was performed and five preclinical and two clinical...

  20. Numerical modelling of Charpy-V notch test by local approach to fracture. Application to an A508 steel in the ductile-brittle transition range; Modelisation de l'essai Charpy par l'approche locale de la rupture. Application au cas de l'acier 16MND5 dans le domaine de transition

    Energy Technology Data Exchange (ETDEWEB)

    Tanguy, B

    2001-07-15

    of the notch as well as plastic deformations superior to 100%. After a fractography study allowing to identify the nature of the sites which lead to the cleavage initiation, the numerical study shows, particularly, the effect of the adiabatic heating and the taking into account of the growth of cavities around a second population of particles (carbides) on the ductile fissure. The application of the proposed methodology allows to describe the resilience data until middle energies of about 70 J. Beyond, an appearing weak dependency of the cleavage constraint with temperature has to be introduced. On the other hand, the evolving of the toughness can be described until middle values of 170 MPa/m without introducing dependency of the cleavage constraint with temperature. (O.M.)

  1. Planning a Successful Tech Show

    Science.gov (United States)

    Nikirk, Martin

    2011-01-01

    Tech shows are a great way to introduce prospective students, parents, and local business and industry to a technology and engineering or career and technical education program. In addition to showcasing instructional programs, a tech show allows students to demonstrate their professionalism and skills, practice public presentations, and interact…

  2. Measuring performance at trade shows

    DEFF Research Database (Denmark)

    Hansen, Kåre

    2004-01-01

    Trade shows is an increasingly important marketing activity to many companies, but current measures of trade show performance do not adequately capture dimensions important to exhibitors. Based on the marketing literature's outcome and behavior-based control system taxonomy, a model is built...... that captures a outcome-based sales dimension and four behavior-based dimensions (i.e. information-gathering, relationship building, image building, and motivation activities). A 16-item instrument is developed for assessing exhibitors perceptions of their trade show performance. The paper presents evidence...

  3. Tokyo Motor Show 2003; Tokyo Motor Show 2003

    Energy Technology Data Exchange (ETDEWEB)

    Joly, E.

    2004-01-01

    The text which follows present the different techniques exposed during the 37. Tokyo Motor Show. The report points out the great tendencies of developments of the Japanese automobile industry. The hybrid electric-powered vehicles or those equipped with fuel cells have been highlighted by the Japanese manufacturers which allow considerable budgets in the research of less polluting vehicles. The exposed models, although being all different according to the manufacturer, use always a hybrid system: fuel cell/battery. The manufacturers have stressed too on the intelligent systems for navigation and safety as well as on the design and comfort. (O.M.)

  4. Risk Aversion in Game Shows

    DEFF Research Database (Denmark)

    Andersen, Steffen; Lau, Morten I.; Rutström, E. Elisabet

    2008-01-01

    , and the dynamic nature of the task in most games. We consider the game shows Card Sharks, Jeopardy!, Lingo, and finally Deal Or No Deal. We provide a detailed case study of the analyses of Deal Or No Deal, since it is suitable for inference about risk attitudes and has attracted considerable attention....

  5. Pembrolizumab Shows Promise for NSCLC.

    Science.gov (United States)

    2015-06-01

    Data from the KEYNOTE-001 trial show that pembrolizumab improves clinical outcomes for patients with advanced non-small cell lung cancer, and is well tolerated. PD-L1 expression in at least 50% of tumor cells correlated with improved efficacy.

  6. Phyllodes tumor showing intraductal growth.

    Science.gov (United States)

    Makidono, Akari; Tsunoda, Hiroko; Mori, Miki; Yagata, Hiroshi; Onoda, Yui; Kikuchi, Mari; Nozaki, Taiki; Saida, Yukihisa; Nakamura, Seigo; Suzuki, Koyu

    2013-07-01

    Phyllodes tumor of the breast is a rare fibroepithelial lesion and particularly uncommon in adolescent girls. It is thought to arise from the periductal rather than intralobular stroma. Usually, it is seen as a well-defined mass. Phyllodes tumor showing intraductal growth is extremely rare. Here we report a girl who has a phyllodes tumor with intraductal growth.

  7. Reality show: um paradoxo nietzschiano

    Directory of Open Access Journals (Sweden)

    Ilana Feldman

    2011-01-01

    Full Text Available

    O fenômeno dos reality shows - e a subseqüente relação entre imagem e verdade - assenta-se sobre uma série de paradoxos. Tais paradoxos podem ser compreendidos à luz do pensamento do filósofo alemão Friedrich Nietzsche, que, através dos usos de formulações paradoxais, concebia a realidade como um mundo de pura aparência e a verdade como um acréscimo ficcional, como um efeito. A ficção é então tomada, na filosofia de Nietzsche, não em seu aspecto falsificante e desrealizador - como sempre pleiteou nossa tradição metafísica -, mas como condição necessária para que certa espécie de invenção possa operar como verdade. Sendo assim, a própria expressão reality show, através de sua formulação paradoxal, engendra explicitamente um mundo de pura aparência, em que a verdade, a parte reality da proposição, é da ordem do suplemento, daquilo que se acrescenta ficcionalmente - como um adjetivo - a show. O ornamento, nesse caso, passa a ocupar o lugar central, apontando para o efeito produzido: o efeito-de-verdade. Seguindo, então, o pensamento nietzschiano e sua atualização na contemporaneidade, investigaremos de que forma os televisivos “shows de realidade” operam paradoxalmente, em consonância com nossas paradoxais práticas culturais.

  8. Picasso on Show in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A staff member of the National Picasso Museum of France checks one of the great Spanish artist Pablo Picasso’s works at the China Pavilion inside the site of the 2010 World Expo in Shanghai on October 12.Sixty-two priceless paintings and statues selected from the works of the renowned artist have been brought to the pavilion for an upcoming exhibition to premiere on October 18.Besides these representative masterpieces,50 valuable photographs showing the artist’s whole life will also be presented.The exhibition’s estimated value is 678 million euros ($934 million).It will be held until January 10,2012.

  9. Graphene Oxides Show Angiogenic Properties.

    Science.gov (United States)

    Mukherjee, Sudip; Sriram, Pavithra; Barui, Ayan Kumar; Nethi, Susheel Kumar; Veeriah, Vimal; Chatterjee, Suvro; Suresh, Kattimuttathu Ittara; Patra, Chitta Ranjan

    2015-08-05

    Angiogenesis, a process resulting in the formation of new capillaries from the pre-existing vasculature plays vital role for the development of therapeutic approaches for cancer, atherosclerosis, wound healing, and cardiovascular diseases. In this report, the synthesis, characterization, and angiogenic properties of graphene oxide (GO) and reduced graphene oxide (rGO) have been demonstrated, observed through several in vitro and in vivo angiogenesis assays. The results here demonstrate that the intracellular formation of reactive oxygen species and reactive nitrogen species as well as activation of phospho-eNOS and phospho-Akt might be the plausible mechanisms for GO and rGO induced angiogenesis. The results altogether suggest the possibilities for the development of alternative angiogenic therapeutic approach for the treatment of cardiovascular related diseases where angiogenesis plays a significant role.

  10. "Medicine show." Alice in Doctorland.

    Science.gov (United States)

    1987-01-01

    This is an excerpt from the script of a 1939 play provided to the Institute of Social Medicine and Community Health by the Library of Congress Federal Theater Project Collection at George Mason University Library, Fairfax, Virginia, pages 2-1-8 thru 2-1-14. The Federal Theatre Project (FTP) was part of the New Deal program for the arts 1935-1939. Funded by the Works Progress Administration (WPA) its goal was to employ theater professionals from the relief rolls. A number of FTP plays deal with aspects of medicine and public health. Pageants, puppet shows and documentary plays celebrated progress in medical science while examining social controversies in medical services and the public health movement. "Medicine Show" sharply contrasts technological wonders with social backwardness. The play was rehearsed by the FTP but never opened because funding ended. A revised version ran on Broadway in 1940. The preceding comments are adapted from an excellent, well-illustrated review of five of these plays by Barabara Melosh: "The New Deal's Federal Theatre Project," Medical Heritage, Vol. 2, No. 1 (Jan/Feb 1986), pp. 36-47.

  11. Reality shows: uma abordagem psicossocial

    Directory of Open Access Journals (Sweden)

    Marília Pereira Bueno Millan

    Full Text Available Desde os primórdios da civilização, o ser humano mostra necessidade de representar cenicamente seus dramas pessoais e vicissitudes existenciais. O "reality show" é uma das versões pós-modernas da encenação da vida humana. Este artigo, por meio de uma pesquisa bibliográfica, analisa criticamente as relações existentes entre o "reality show" e aspectos psicossociais do comportamento humano. Conclui-se que tais programas televisivos são o retrato da contemporaneidade, ou seja, revelam a morte do sujeito, a fugacidade das experiências vividas, a desvalorização da história e o culto à imagem e à superficialidade. Por meio da sedução do espectador, mobilizam-se aspectos primitivos de seu psiquismo, fazendo com que ele se sinta narcisicamente poderoso e onipotente e se acredite dono do destino dos participantes do programa. Sugerem-se novos estudos que contribuam para a reflexão crítica e maior conscientização.

  12. Casimir experiments showing saturation effects

    CERN Document Server

    Sernelius, Bo E

    2009-01-01

    We address several different Casimir experiments where theory and experiment disagree. First out is the classical Casimir force measurement between two metal half spaces; here both in the form of the torsion pendulum experiment by Lamoreaux and in the form of the Casimir pressure measurement between a gold sphere and a gold plate as performed by Decca et al.; theory predicts a large negative thermal correction, absent in the high precision experiments. The third experiment is the measurement of the Casimir force between a metal plate and a laser irradiated semiconductor membrane as performed by Chen et al.; the change in force with laser intensity is larger than predicted by theory. The fourth experiment is the measurement of the Casimir force between an atom and a wall in the form of the measurement by Obrecht et al. of the change in oscillation frequency of a 87 Rb Bose-Einstein condensate trapped to a fused silica wall; the change is smaller than predicted by theory. We show that saturation effects can exp...

  13. Online Italian fandoms of American TV shows

    Directory of Open Access Journals (Sweden)

    Eleonora Benecchi

    2015-06-01

    Full Text Available The Internet has changed media fandom in two main ways: it helps fans connect with each other despite physical distance, leading to the formation of international fan communities; and it helps fans connect with the creators of the TV show, deepening the relationship between TV producers and international fandoms. To assess whether Italian fan communities active online are indeed part of transnational online communities and whether the Internet has actually altered their relationship with the creators of the original text they are devoted to, qualitative analysis and narrative interviews of 26 Italian fans of American TV shows were conducted to explore the fan-producer relationship. Results indicated that the online Italian fans surveyed preferred to stay local, rather than using geography-leveling online tools. Further, the sampled Italian fans' relationships with the show runners were mediated or even absent.

  14. This research is to study the factors which influence the business success of small business ‘processed rotan’. The data employed in the study are primary data within the period of July to August 2013, 30 research observations through census method. Method of analysis used in the study is multiple linear regressions. The results of analysis showed that the factors of labor, innovation and promotion have positive and significant influence on the business success of small business ‘processed rotan’ simultaneously. The analysis also showed that partially labor has positive and significant influence on the business success, yet innovation and promotion have insignificant and positive influence on the business success.

    OpenAIRE

    Nasution, Inggrita Gusti Sari; Muchtar, Yasmin Chairunnisa

    2013-01-01

    This research is to study the factors which influence the business success of small business ‘processed rotan’. The data employed in the study are primary data within the period of July to August 2013, 30 research observations through census method. Method of analysis used in the study is multiple linear regressions. The results of analysis showed that the factors of labor, innovation and promotion have positive and significant influence on the business success of small busine...

  15. A study of the fracture process and factors that control toughness variability in Charpy V-notch specimens

    Science.gov (United States)

    Bouchard, Real

    La presente etude a ete initiee pour developper une comprehension quantitative du processus de rupture avec les facteurs qui controlent la dispersion des mesures de tenacite lorsque des eprouvettes Charpy entaillees en V sont utilisees. Un grand nombre d'essais ont ete realises pour un acier C-Mn: eprouvettes Charpy testees sous impact, eprouvettes Charpy testees en flexion lente, eprouvettes axisymetriques entaillees et sollicitees en traction et essais de tenacite sur eprouvettes prefissurees. Base sur le concept de la statistique de Weibull, l'approche locale developpee par le groupe Beremin a ete utilisee pour decrire la probabilite de rupture par clivage en fonction de la contrainte appliquee aussi bien qu'en fonction de l'energie Charpy obtenue. Le calcul par elements finis a ete realise pour determiner la distribution de la deformation et des contraintes en pointe d'entaille et de fissure. La nouvelle approche introduite decrit bien les resultats experimentaux. Les points d'initiation du clivage ont ete identifies au MEB et par la suite, avec la technique de faisceau d'ions focalise, sectionnes, polis et examines. L'examen de la microstructure sous le point d'initiation revele clairement que le clivage s'initie par un mecanisme d'empilement de dislocations ou les dislocations sont arretees aux joints de grain, aux interfaces de perlite/ferrite ou de perlite qui agissent comme barrieres physiques.

  16. Ancient bacteria show evidence of DNA repair

    DEFF Research Database (Denmark)

    Johnson, Sarah Stewart; Hebsgaard, Martin B; Christensen, Torben R

    2007-01-01

    Recent claims of cultivable ancient bacteria within sealed environments highlight our limited understanding of the mechanisms behind long-term cell survival. It remains unclear how dormancy, a favored explanation for extended cellular persistence, can cope with spontaneous genomic decay over......-term survival of bacteria sealed in frozen conditions for up to one million years. Our results show evidence of bacterial survival in samples up to half a million years in age, making this the oldest independently authenticated DNA to date obtained from viable cells. Additionally, we find strong evidence...... that this long-term survival is closely tied to cellular metabolic activity and DNA repair that over time proves to be superior to dormancy as a mechanism in sustaining bacteria viability....

  17. Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase.

    Science.gov (United States)

    Thöny, Beat; Calvo, Ana C; Scherer, Tanja; Svebak, Randi M; Haavik, Jan; Blau, Nenad; Martinez, Aurora

    2008-07-01

    Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamine neurotransmitters. Primary inherited defects in TH have been associated with l-DOPA responsive and non-responsive dystonia and infantile parkinsonism. In this study, we show that both the cofactor (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) and the feedback inhibitor and catecholamine product dopamine increase the kinetic stability of human TH isoform 1 in vitro. Activity measurements and synthesis of the enzyme by in vitro transcription-translation revealed a complex regulation by the cofactor including both enzyme inactivation and conformational stabilization. Oral BH(4) supplementation to mice increased TH activity and protein levels in brain extracts, while the Th-mRNA level was not affected. All together our results indicate that the molecular mechanisms for the stabilization are a primary folding-aid effect of BH(4) and a secondary effect by increased synthesis and binding of catecholamine ligands. Our results also establish that orally administered BH(4) crosses the blood-brain barrier and therapeutic regimes based on BH(4) supplementation should thus consider the effect on TH. Furthermore, BH(4) supplementation arises as a putative therapeutic agent in the treatment of brain disorders associated with TH misfolding, such as for the human TH isoform 1 mutation L205P.

  18. Ribavirin shows immunomodulatory effects on activated microglia.

    Science.gov (United States)

    Savic, Danijela; Stojiljkovic, Mirjana; Lavrnja, Irena; Parabucki, Ana; Bjelobaba, Ivana; Nedeljkovic, Nadezda; Herdegen, Thomas; Pekovic, Sanja

    2014-12-01

    Abstract Ribavirin (RBV) is synthetic purine nucleoside analogue, licensed as anti-viral drug that displays immunomodulatory actions on various immune cells. Our previous ex vivo studies have demonstrated immunosuppressive effects of RBV on reactive T-lymphocytes in experimental autoimmune encephalomyelitis. Here, we examined the effects of RBV on inflammatory response of microglia. RBV potency to down-regulate microglia inflammatory response was assessed by measuring microglia cell body size, and the production of nitric oxide (NO) and pro- and anti-inflammatory cytokines. RBV exerted cytotoxic effects on LPS-stimulated microglia, leaving non-stimulated microglia unaffected. The exposure of activated microglia to RBV led to: decrease in the level of NO as a result of decreased cell number, lower average cell surface, the reduction of membrane ruffling, the suppression of interleukin-6 release and promoted interleukin-10 production. On the other hand, RBV promoted LPS-induced interleukin-1 beta release. Our results imply that RBV is a complex immunomodulator showing both anti- and pro-inflammatory effects on activated microglia.

  19. The Combination of Pixantrone, Etoposide, Bendamustine and, in CD20+ Tumors, Rituximab (PREBEN) Shows Promising Feasibility/Efficacy in Heavily Pre-Treated Aggressive Lymphomas of B- and T-Cell Phenotype - Results of the Pre-Trial Experience Leading to a Nordic Phase 1/2 Study (the PREBEN Trial)

    DEFF Research Database (Denmark)

    Clausen, Michael Roost; Leppa, Sirpa; Brown, Peter de Nully

    2016-01-01

    a complete metabolic response (CMR) and seven (23 a partial one (PMR), resulting in an overall response rate (ORR) of 50 Among the histological subtypes, the patients with DLBCL, PTCL and tIND had an ORR of 53% (CMR 35, 57% (CMR 14, and 33% (CMR in one out of two responders), respectively. Most responses......-containing salvage therapies, and two had relapses occurring after a post-transplant remission period. While most of the relapsed patients with DLBCL responded , i.e. seven (five CMR and two PMR) of the nine (78 frail relapsed patients and one of the two (50 patients with post-transplant relapses, only one out six...... (17 primary refractory patients exhibited some chemosensitivity. Interestingly, four out of seven PTCL patients achieved a PMR or CMR allowing them to undergo non-myeloablative allogeneic transplant with subsequent sustained response durations. The treatment schedule was feasible and most patients...

  20. NASA GIBS Use in Live Planetarium Shows

    Science.gov (United States)

    Emmart, C. B.

    2015-12-01

    The American Museum of Natural History's Hayden Planetarium was rebuilt in year 2000 as an immersive theater for scientific data visualization to show the universe in context to our planet. Specific astrophysical movie productions provide the main daily programming, but interactive control software, developed at AMNH allows immersive presentation within a data aggregation of astronomical catalogs called the Digital Universe 3D Atlas. Since 2006, WMS globe browsing capabilities have been built into a software development collaboration with Sweden's Linkoping University (LiU). The resulting Uniview software, now a product of the company SCISS, is operated by about fifty planetariums around that world with ability to network amongst the sites for global presentations. Public presentation of NASA GIBS has allowed authoritative narratives to be presented within the range of data available in context to other sources such as Science on a Sphere, NASA Earth Observatory and Google Earth KML resources. Specifically, the NOAA supported World Views Network conducted a series of presentations across the US that focused on local ecological issues that could then be expanded in the course of presentation to national and global scales of examination. NASA support of for GIBS resources in an easy access multi scale streaming format like WMS has tremendously enabled particularly facile presentations of global monitoring like never before. Global networking of theaters for distributed presentations broadens out the potential for impact of this medium. Archiving and refinement of these presentations has already begun to inform new types of documentary productions that examine pertinent, global interdependency topics.

  1. MRI shows clodronate-liposomes attenuating liverinjuryinratswithsevereacutepancreatitis

    Institute of Scientific and Technical Information of China (English)

    Jian-Xin Zhang; Sheng-Chun Dang; Yong Zhang; Xin Sha; Li-Rong Zhang; Chuan-She Wei; Min Chen; De-Li Jiang

    2010-01-01

    BACKGROUND: Studies have revealed that macrophages play an important role in the development of severe acute pancreatitis (SAP). Activated macrophages can lead to a systemic inlfammatory response, induce lipid peroxidation, impair membrane structure, result in injury to the liver and the other extrahepatic organs, and eventually result in multiple organ dysfunction syndrome by promoting excessive secretion of cytokines. Liver injury can further aggravate the systemic inlfammatory response and increase mortality by affecting the metabolism of toxins and the release of excessive inlfammatory mediators. Clodronate is a synthetic bisphosphonate, which is often used for treating bone changes caused by osteoporosis and other factors. In the current study, we created liposomes containing superparamagnetic iron oxide particles (SPIOs) for macrophage labeling and magnetic resonance imaging, using a novel method that can bind the clodronate to induce apoptosis and deplete macrophages. METHODS: Superparamagnetic Fe3O4 nanoparticles were prepared by chemical coprecipitation. SPIO-containing liposomes and SPIO-clodronate-containing liposomes were prepared by the thin iflm method. SAP models were prepared by injection of sodium taurocholate (2 ml/kg body weight) into the subcapsular space of the pancreas. Sprague-Dawley rats were randomly divided into a control group, a SAP plus SPIO-liposome group, and a SAP plus SPIO-clodronate-containing group. Two and six hours after SAP models were available, T2-weighted MRI scans (in the same plane) of the livers of rats in each group were performed. At the end of the scans, 2 ml of blood was taken from the superior mesenteric vein to measure the levels of serum amylase, ALT, AST, TNF-α, and IL-6. Pathological changes in the liver and pancreas were assessed. RESULTS: Transmission electron microscopy showed that the liposomes had a uniform size. No pathological changes in the pancreata of rats in the control group were noted. The

  2. Fabrics China Creation Show Hold in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ On August 5-6th.the 3rd Fabrics China Creation Show(one series events of Reach & Touch),organized by China National Textile & Apparel Council and National Textile Development Center,was held in Shanghai,aiming to providing textile producers and designers a platform to show their inspirations and creative ideas in fabric design.

  3. Serving Up Activities for TV Cooking Shows.

    Science.gov (United States)

    Katchen, Johanna E.

    This paper documents a presentation given on the use of English-language television cooking shows in English-as-a-Second-Language (ESL) and English-as-a-Foreign-Language (EFL) classrooms in Taiwan. Such shows can be ideal for classroom use, since they have a predictable structure consisting of short segments, are of interest to most students,…

  4. Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone.

    Science.gov (United States)

    Lee, Bruce Y; Bartsch, Sarah M; Wong, Kim F; Yilmaz, S Levent; Avery, Taliser R; Singh, Ashima; Song, Yeohan; Kim, Diane S; Brown, Shawn T; Potter, Margaret A; Platt, Richard; Huang, Susan S

    2012-10-01

    Efforts to control life-threatening infections, such as with methicillin-resistant Staphylococcus aureus (MRSA), can be complicated when patients are transferred from one hospital to another. Using a detailed computer simulation model of all hospitals in Orange County, California, we explored the effects when combinations of hospitals tested all patients at admission for MRSA and adopted procedures to limit transmission among patients who tested positive. Called "contact isolation," these procedures specify precautions for health care workers interacting with an infected patient, such as wearing gloves and gowns. Our simulation demonstrated that each hospital's decision to test for MRSA and implement contact isolation procedures could affect the MRSA prevalence in all other hospitals. Thus, our study makes the case that further cooperation among hospitals--which is already reflected in a few limited collaborative infection control efforts under way--could help individual hospitals achieve better infection control than they could achieve on their own.

  5. Are Corporate Universities (CU possible in emerging countries? A survey conducted in Argentina showed impacting results

    Directory of Open Access Journals (Sweden)

    Leandro A. Viltard

    2014-09-01

    Full Text Available At the time of our investigation, the CU was not a widespread concept in Argentina, being viewed as a “foreign - far long project” (coming from developed countries and standing for the long term. It is suggested that the rate of CU evolution, in emerging countries like Argentina, is more related to mentality issues than to CU strategic or operative limitations. Although the executives who replied to a survey were not the only power factor in their organization, their comments allow us to think that, in those countries, the CU may have a better future perspective. The research used a quali-quantitative methodology, which was based on a survey to top executives of different kinds of companies located in Argentina. The research design was not experimental and transversal, as it was limited to a specific moment in time.

  6. Voyeurismo Televisivo, Reality Shows e Brasilidade Televisiva

    Directory of Open Access Journals (Sweden)

    Suzana Kilpp

    2008-12-01

    Full Text Available In the last years we watched a boom of reality shows in the media and also in the academic production specialized in this subject. It remains, however, a epistemological gap related to the aesthetic and techniques (which are related to the televisions grammars that TV uses in these programs to enunciate ethics directions to its own voyeurism, that goes far beyond reality shows, having repercussions on social imaginary of transparency and surveillance, and the redesign of public and private spaces. In this gap, the article points out the debate of Brazilian reality shows in the perspective of the televisions grammars.

  7. UV Photography Shows Hidden Sun Damage

    Science.gov (United States)

    ... mcat1=de12", ]; for (var c = 0; c UV photography shows hidden sun damage A UV photograph gives ... developing skin cancer and prematurely aged skin. Normal photography UV photography 18 months of age: This boy's ...

  8. Fecal Transplant Shows Early Promise Against Autism

    Science.gov (United States)

    ... 163263.html Fecal Transplant Shows Early Promise Against Autism Small study found giving healthy gut bacteria to ... study suggests a novel treatment for kids with autism: Give these young patients a fresh supply of ...

  9. Study Shows How Zika Attacks Infant Brain

    Science.gov (United States)

    ... gov/news/fullstory_162514.html Study Shows How Zika Attacks Infant Brain Virus can copy itself thousands ... New research paints a chilling portrait of how Zika ravages the infant brain. Scientists from the U.S. ...

  10. Poverty Harder on Women's Hearts, Research Shows

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163168.html Poverty Harder on Women's Hearts, Research Shows Poor females ... reduce the burden of cardiovascular disease around the world," Peters said. The study findings were published online ...

  11. Fabrics China Creation Show Held in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    On August 5-6th,the 3rd Fabrics China Creation Show (one series events of Reach & Touch),organized by China National Textile & Apparel Council and National Textile Development Center,was held in Shanghai,

  12. Voyeurismo Televisivo, Reality Shows e Brasilidade Televisiva

    OpenAIRE

    Suzana Kilpp

    2008-01-01

    In the last years we watched a boom of reality shows in the media and also in the academic production specialized in this subject. It remains, however, a epistemological gap related to the aesthetic and techniques (which are related to the televisions grammars) that TV uses in these programs to enunciate ethics directions to its own voyeurism, that goes far beyond reality shows, having repercussions on social imaginary of transparency and surveillance, and the redesign of public and private s...

  13. 2008 LHC Open Days Physics: the show

    CERN Multimedia

    2008-01-01

    A host of events and activities await visitors to the LHC Open Days on 5 and 6 April. A highlight will be the physics shows funded by the European Physical Society (EPS), which are set to surprise and challenge children and adults alike! School children use their experience of riding a bicycle to understand how planets move around the sun (Copyright : Circus Naturally) Participating in the Circus Naturally show could leave a strange taste in your mouth! (Copyright : Circus Naturally) The Rino Foundation’s experiments with liquid nitrogen can be pretty exciting! (Copyright: The Rino Foundation)What does a bicycle have in common with the solar system? Have you ever tried to weigh air or visualise sound? Ever heard of a vacuum bazooka? If you want to discover the answers to these questions and more then come to the Physics Shows taking place at the CERN O...

  14. Liquid Crystal Research Shows Deformation By Drying

    Science.gov (United States)

    2003-01-01

    These images, from David Weitz's liquid crystal research, show ordered uniform sized droplets (upper left) before they are dried from their solution. After the droplets are dried (upper right), they are viewed with crossed polarizers that show the deformation caused by drying, a process that orients the bipolar structure of the liquid crystal within the droplets. When an electric field is applied to the dried droplets (lower left), and then increased (lower right), the liquid crystal within the droplets switches its alignment, thereby reducing the amount of light that can be scattered by the droplets when a beam is shone through them.

  15. The British Show in Australia, 1985

    Directory of Open Access Journals (Sweden)

    Anthony Bond

    2016-07-01

    Full Text Available In 1984–85, The British Show, an exhibition largely made up of New British Sculpture, was curated for Australia and New Zealand. This essay discusses the context and effects of the exhibition on art in Australia. It also seeks to define the sources of originality and innovation of the artists included.

  16. Show Them You Really Want the Job

    Science.gov (United States)

    Perlmutter, David D.

    2012-01-01

    Showing that one really "wants" the job entails more than just really wanting the job. An interview is part Broadway casting call, part intellectual dating game, part personality test, and part, well, job interview. When there are 300 applicants for a position, many of them will "fit" the required (and even the preferred) skills listed in the job…

  17. TV-Show Retrieval and Classification

    NARCIS (Netherlands)

    Musto, C.; Narducci, F.; Lops, P.; Semeraro G.; Gemmis, M. de; Barbieri, M.; Korst, J.H.M.; Pronk, S.P.P.; Clout, R.A.W.

    2012-01-01

    Recommender systems are becoming popular tools to aid users in finding interesting and relevant TV-shows and other digital video assets,based on implicitly learned user preferences. In this context, a common assumption is that user preferences can be specified by program types (movie, sports, ...) a

  18. Development, management and economy of show caves.

    Directory of Open Access Journals (Sweden)

    Cigna Arrigo A.

    2000-01-01

    Full Text Available The problems concerning the development of show caves are here considered by taking into account different aspects of the problem. A procedure to carry out an Environmental Impact Assessment (EIA has been established in the last decade and it is now currently applied. Such an assessment starts with a pre-operational phase to obtain sufficient information on the undisturbed status of a cave to be developed into a show cave. Successively a programme for its development is established with the scope to optimise the intervention on the cave at the condition that its basic environmental parameters are not irreversibly modified. The last phase of the assessment is focussed to assure a feedback through a monitoring network in order to detect any unforeseen difference or anomaly between the project and the effective situation achieved after the cave development. Some data on some of the most important show caves in the world are reported and a tentative evaluation of the economy in connection with the show caves business is eventually made.

  19. A Talk Show from the Past.

    Science.gov (United States)

    Gallagher, Arlene F.

    1991-01-01

    Describes a two-day activity in which elementary students examine voting rights, the right to assemble, and women's suffrage. Explains the game, "Assemble, Reassemble," and a student-produced talk show with five students playing the roles of leaders of the women's suffrage movement. Profiles Elizabeth Cady Stanton, Lucretia Mott, Susan…

  20. The Last Great American Picture Show

    NARCIS (Netherlands)

    Elsaesser, Thomas; King, Noel; Horwath, Alexander

    2004-01-01

    The Last Great American Picture Show brings together essays by scholars and writers who chart the changing evaluations of the American cinema of the 1970s, sometimes referred to as the decade of the lost generation, but now more and more recognized as the first New Hollywood, without which the cinem

  1. Gene Therapy Shows Promise for Aggressive Lymphoma

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_163824.html Gene Therapy Shows Promise for Aggressive Lymphoma Over one-third ... TUESDAY, Feb. 28, 2017 (HealthDay News) -- An experimental gene therapy for aggressive non-Hodgkin lymphoma beat back more ...

  2. La mujer, en los talk shows

    Directory of Open Access Journals (Sweden)

    Antrop. José Gamboa Cetina

    2001-01-01

    Full Text Available Dentro de los medios de comunicación, uno de los que más ha impactado a la población latinoamericana ha sido la televisión, y en la barra programática de las televisoras ha surgido un tipo de programas denominados talk shows. En los últimos meses, la sociedad mexicana ha vivido el "boom" de los talk shows, que en poco tiempo han saturado la barra de la programación vespertina de las dos principales empresas televisivas de la república mexicana. Este fenómeno puede estudiarse desde diversas perspectivas. Sin embargo, por motivos de espacio, en esta ocasión analizaremos su impacto en las mujeres, desde diferentes dimensiones.

  3. 2009 Hands Across Pacific Show Held

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    <正>The 2009 Hands Across the Pacific Show co-sponsored by the Canadian International Cultural Exchanges (CICEX) and Hunan Provincial People’s Association for Friendship with Foreign Countries(HPPAFFC) was held respectively in the Tower Hall of Tokyo,Japan from July 2 to 7 and in the Hunan Provincial Museum from August 1 to 5.Jing Dunquan,Vice President of the

  4. The People's Show: A Critical Analysis

    OpenAIRE

    Robin Francis

    1996-01-01

    The 1990s heralded a new form of museum exhibition: "The People's Show." A light-hearted celebration of popular culture, the concept has had phenomenal success throughout the United Kingdom. Beneath the humour, however, are more complex and radical agendas relating to cultural rights. The paper explores the issues associated with the rise and possible wane of this museum-based popular cultural phenomenon.

  5. Reality, ficción o show

    Directory of Open Access Journals (Sweden)

    Sandra Ruíz Moreno

    2002-01-01

    Full Text Available Para tener un punto de vista claro y objetivo frente a la polémica establecida en torno al programa “Protagonistas de novela” y la tendiente proliferación de los reality show en las parrillas de programación de la televisión colombiana, se realizó un análisis de texto y contenido de dicho programa, intentando definirlo desde sus posibilidades de realidad, ficción y show. Las unidades de análisis y el estudio de su tratamiento arrojaron un alto contenido que gira en torno a las emociones del ser humano relacionadas con la convivencia, tratadas a manera de show y con algunos aportes textuales de ficción, pero sin su elemento mediador básico, el actor, quitándole toda la posibilidad de tener un tratamiento con la profundidad, distancia y ética que requieren los temas de esta índole. El resultado es un formato que sólo busca altos índices de sintonía y que pertenece más a la denominada televisión “trash”, que a una búsqueda de realidad del hombre y mucho menos de sociedad.

  6. Bite my art to show your love

    OpenAIRE

    Kim, Hye yeon

    2012-01-01

    Two years ago, I came to the States for MFA program in UCSD. At first, I started making instructions for performance to communicate with people in my clumsy English, but it soon became my general process of working. In this show, I present a room surrounded by five video projections and drawings. They are documentation of performances concerning the balance of relationship. I performed two with Josh Aaron, other two with Josh Tonies, and one by myself. The performance done by myself reveals t...

  7. Showing and Saying. An Aesthetic Difference

    Directory of Open Access Journals (Sweden)

    Vicente Sanfélix Vidarte

    2013-05-01

    Full Text Available Wittgenstein’s distinction between saying and showing and the associated thesis, what can be shown cannot be said, were crucial to his first philosophy, persisted throughout the evolution of his whole thought and played a key role in his views on aesthetics. The objective of art is access to the mystical, forcing us to become aware of the uniqueness of our own experience and life. When art is good is a perfect expression and the work of art becomes like a tautology. An important consequence of this understanding of art is the irreducibility of the aesthetic to the scientific perspective.

  8. Latest European coelacanth shows Gondwanan affinities.

    Science.gov (United States)

    Cavin, Lionel; Forey, Peter L; Buffetaut, Eric; Tong, Haiyan

    2005-06-22

    The last European fossil occurrence of a coelacanth is from the Mid-Cretaceous of the English Chalk (Turonian, 90 million years ago). Here, we report the discovery of a coelacanth from Late Cretaceous non-marine rocks in southern France. It consists of a left angular bone showing structures that imply close phylogenetic affinities with some extinct Mawsoniidae. The closest relatives are otherwise known from Cretaceous continental deposits of southern continents and suggest that the dispersal of freshwater organisms from Africa to Europe occurred in the Late Cretaceous.

  9. Tomato Fruits Show Wide Phenomic Diversity but Fruit Developmental Genes Show Low Genomic Diversity.

    Science.gov (United States)

    Mohan, Vijee; Gupta, Soni; Thomas, Sherinmol; Mickey, Hanjabam; Charakana, Chaitanya; Chauhan, Vineeta Singh; Sharma, Kapil; Kumar, Rakesh; Tyagi, Kamal; Sarma, Supriya; Gupta, Suresh Kumar; Kilambi, Himabindu Vasuki; Nongmaithem, Sapana; Kumari, Alka; Gupta, Prateek; Sreelakshmi, Yellamaraju; Sharma, Rameshwar

    2016-01-01

    Domestication of tomato has resulted in large diversity in fruit phenotypes. An intensive phenotyping of 127 tomato accessions from 20 countries revealed extensive morphological diversity in fruit traits. The diversity in fruit traits clustered the accessions into nine classes and identified certain promising lines having desirable traits pertaining to total soluble salts (TSS), carotenoids, ripening index, weight and shape. Factor analysis of the morphometric data from Tomato Analyzer showed that the fruit shape is a complex trait shared by several factors. The 100% variance between round and flat fruit shapes was explained by one discriminant function having a canonical correlation of 0.874 by stepwise discriminant analysis. A set of 10 genes (ACS2, COP1, CYC-B, RIN, MSH2, NAC-NOR, PHOT1, PHYA, PHYB and PSY1) involved in various plant developmental processes were screened for SNP polymorphism by EcoTILLING. The genetic diversity in these genes revealed a total of 36 non-synonymous and 18 synonymous changes leading to the identification of 28 haplotypes. The average frequency of polymorphism across the genes was 0.038/Kb. Significant negative Tajima'D statistic in two of the genes, ACS2 and PHOT1 indicated the presence of rare alleles in low frequency. Our study indicates that while there is low polymorphic diversity in the genes regulating plant development, the population shows wider phenotype diversity. Nonetheless, morphological and genetic diversity of the present collection can be further exploited as potential resources in future.

  10. Figure of Beijing ABP Showing up

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Last year, there were many good news from Beijing Advanced Business Park(ABP): on October 29, 2005, Xu Weiping, Chairman of the Board of ABP, was chosen as the"2005 Ten Major Chinese Administrative Person in News";On November 8,2005,CCIM (American Certified Commercial Investment Member) invited 40 world famous real estate investors to visit ABS and they showed will to cooperate; On November 22, 2005, Johnson Controls, Inc., one of World Top 500, signed the contract with Zhongguan Village Fengtai Garden that the headquarter of JCI energy administration China Branch will move to ABP to improve the energy administration and radiate all the nation; on December 10,2005, "CEO Salon" co-organized by Phoenix Satellite Television and ABP, was held in the meeting room of ABP, over 120CEOs met here to discuss the trend of China economic development and the development opportunities brought by 11th Five-Year Plan for enterprises.

  11. Star Shows It Has The Right Stuff

    Science.gov (United States)

    2004-01-01

    Astronomers have used an observation by NASA's Chandra X-ray Observatory to make the best case yet that a star can be engulfed by its companion star and survive. This discovery will help astronomers better understand how closely coupled stars, and perhaps even stars and planets, evolve when one of the stars expands enormously in its red giant phase. The binary star system known as V471 Tauri comprises a white dwarf star (the primary) in a close orbit -- one thirtieth of the distance between Mercury and the Sun -- with a normal Sun-like star (the secondary). Chandra's data showed that the hot upper atmosphere of the secondary star has a deficit of carbon atoms relative to nitrogen atoms. "This deficit of carbon atoms is the first clear observational evidence that the normal star was engulfed by its companion in the past," according to Jeremy Drake of the Smithsonian Astrophysical Observatory in Cambridge, MA, who coauthored an article on V471 in The Astrophysical Journal Letters with Marek Sarna of the N. Copernicus Astronomical Center in Poland. The white dwarf star was once a star several times as massive as the Sun. Nuclear fusion reactions in the core of such a star convert carbon into nitrogen over a period of about a billion years. When the fuel in the core of the star is exhausted, the core collapses, triggering more energetic nuclear reactions that cause the star to expand and transform into a red giant before eventually collapsing to become a white dwarf. The carbon-poor material in the core of the red giant is mixed with outer part of the star, so its atmosphere shows a deficit of carbon, as compared with Sun-like stars. The X-ray spectra of a red giant star (top panel) and a Sun-like star (bottom panel) show the large difference in the peaks due to carbon atoms in the two stars. Theoretical calculations indicate that a red giant in a binary system can completely envelop its companion star and dramatically affect its evolution. During this common envelope

  12. Nature's Late-Night Light Shows

    Science.gov (United States)

    Peterson, Carolyn Collins

    2002-09-01

    In addition to stars and planets, there are other interesting lights to be seen in the night sky. The northern and southern lights, called the aurora borealis and aurora australis, are created by charged particles from the Sun reacting in Earth's magnetic field. Night-shining clouds or noctilucent clouds appear at evening twilight as a result of water vapor in the polar mesosphere. Zodiacal light can be seen stretching up from the horizon after sunset or before sunrise.

  13. Fungal outbreak in a show cave.

    Science.gov (United States)

    Jurado, V; Porca, E; Cuezva, S; Fernandez-Cortes, A; Sanchez-Moral, S; Saiz-Jimenez, C

    2010-08-01

    Castañar de Ibor Cave (Spain) was discovered in 1967 and declared a Natural Monument in 1997. In 2003 the cave was opened to public visits. Despite of extensive control, on 26 August 2008 the cave walls and sediments appeared colonized by long, white fungal mycelia. This event was the result of an accidental input of detritus on the afternoon of 24 August 2008. We report here a fungal outbreak initiated by Mucor circinelloides and Fusarium solani and the methods used to control it.

  14. The great American medicine show revisited.

    Science.gov (United States)

    Tomes, Nancy

    2005-01-01

    Since the late 1800s, changes in the advertising and marketing of medicinal drugs have produced heated debates in the United States. With the emergence of the modern prescription drug between 1938 and 1951, concerns that once focused primarily on patients' use of over-the-counter drugs were broadened to include physicians and their "doctors' drugs" as well. The medical profession's growing control over their patients' drug choices inevitably heightened the scrutiny of their own performance as consumers. Although deeply divided over issues of the patient's role in medical decision making, consumer activists and physician reformers expressed similar concerns about the impact of aggressive pharmaceutical marketing and advertising on the doctor-patient relationship, and starting in the late 1950s they employed strikingly similar strategies to counter the new corporate "medicine show." Yet their efforts to promote a more rational use of prescription drugs have usually been too little and too late to offset the effectiveness of pharmaceutical advertising and mar-keting activities.

  15. The earliest published electrocardiogram showing ventricular preexcitation.

    Science.gov (United States)

    Von Knorre, Georg H

    2005-03-01

    When in 1930, Wolff, Parkinson, and White published what is today known as the WPW, or preexcitation syndrome, they, and subsequently others, found few comparable cases in the preceding literature. Among these the report of Cohn and Fraser, published in 1913, was the earliest. However, another even earlier documentation in a 1909 article by Hoffmann escaped notice till now. The ECG of a patient with paroxysmal tachycardia reveals a short PR interval and a delta-wave-induced widening of the QRS complex, even though the reproduced tachycardia was not preexcitation related. The interpretation of this poorly reproduced ECG can be confirmed by another and more detailed description of the patient in an electrocardiography textbook published in 1914 by the same author. Thus, the earliest publication of an ECG showing ventricular preexcitation now can be dated back to 1909. Moreover, the Hoffmann monograph contains two additional examples of the WPW syndrome not noticed until now. All three cases published by Hoffmann had their first ECG recordings in 1912 or earlier.

  16. Quantity language speakers show enhanced subcortical processing.

    Science.gov (United States)

    Dawson, Caitlin; Aalto, Daniel; Šimko, Juraj; Putkinen, Vesa; Tervaniemi, Mari; Vainio, Martti

    2016-07-01

    The complex auditory brainstem response (cABR) can reflect language-based plasticity in subcortical stages of auditory processing. It is sensitive to differences between language groups as well as stimulus properties, e.g. intensity or frequency. It is also sensitive to the synchronicity of the neural population stimulated by sound, which results in increased amplitude of wave V. Finnish is a full-fledged quantity language, in which word meaning is dependent upon duration of the vowels and consonants. Previous studies have shown that Finnish speakers have enhanced behavioural sound duration discrimination ability and larger cortical mismatch negativity (MMN) to duration change compared to German and French speakers. The next step is to find out whether these enhanced duration discrimination abilities of quantity language speakers originate at the brainstem level. Since German has a complementary quantity contrast which restricts the possible patterns of short and long vowels and consonants, the current experiment compared cABR between nonmusician Finnish and German native speakers using seven short complex stimuli. Finnish speakers had a larger cABR peak amplitude than German speakers, while the peak onset latency was only affected by stimulus intensity and spectral band. The results suggest that early cABR responses are better synchronised for Finns, which could underpin the enhanced duration sensitivity of quantity language speakers.

  17. Food neophobia shows heritable variation in humans.

    Science.gov (United States)

    Knaapila, Antti; Tuorila, Hely; Silventoinen, Karri; Keskitalo, Kaisu; Kallela, Mikko; Wessman, Maija; Peltonen, Leena; Cherkas, Lynn F; Spector, Tim D; Perola, Markus

    2007-08-15

    Food neophobia refers to reluctance to eat unfamiliar foods. We determined the heritability of food neophobia in a family and a twin sample. The family sample consisted of 28 Finnish families (105 females, 50 males, aged 18-78 years, mean age 49 years) and the twin sample of 468 British female twin pairs (211 monozygous and 257 dizygous pairs, aged 17-82 years, mean age 55 years). Food neophobia was measured using the ten-item Food Neophobia Scale (FNS) questionnaire, and its internationally validated six-item modification. The heritability estimate for food neophobia was 69 and 66% in Finnish families (h(2)) and 67 and 66% in British female twins (a(2)+d(2)) using the ten- and six-item versions of the FNS, respectively. The results from both populations suggest that about two thirds of variation in food neophobia is genetically determined.

  18. STD studies show spermicides protect against Chlamydia.

    Science.gov (United States)

    1986-01-01

    Evidence which suggests that spermicides provide protection against sexually transmitted diseases (STDs) is accumulating. Laboratory tests have repeatedly demonstrated that spermicides are capable of killing the bacteria responsible for several types of STDs, as well as the virus responsible for acquired immunodeficiency syndrome. Recently, studies conducted in Bangkok, Thailand and in New York City suggest that these protective effects are not confined to the laboratory but that they also occur among women who use spermicides in the real world. In the New York City study, Family Health International (FHI), using data collected by Planned Parenthood of New York City, compared STD prevalence rates for women using different contraceptive methods. Women who used spermicides, in comparison with women who used oral contraceptives (OCs), were 20% less likely to have contracted a STD, 30% less likely to have gonorrhea, and 60% less likely to have chlamydia. In the Thai study, conducted jointly by the FHI and the Ministry of Health, women at high risk of STDs were allocated either to a group which was instructed to use a vaginal sponge impregnated with nonoxynol-9 during intercourse or to a control group which received no vaginal contraceptives. All the women were either sterilized or using OCs, IUDs, or injectable contraceptives. Preliminary results suggest that the women who used the vaginal sponges were significantly less likely to contract chlamydia than the control group. In regard to the incidence of gonorrhea, no differences between the 2 groups was detected. In the Thai study methodological problems forced the researchers to redesign the study. In accordance with the new design, the women in the 2 groups will be crossed over after 6 weeks. This will allow the researchers to examine the effect of using or not using a vaginal spermicide on specific individuals. The findings of the 2 studies have special relevance given the increasing prevalence of STDs in many

  19. Quantifying show jumping horse rider expertise using IMUs.

    Science.gov (United States)

    Patterson, M; Doyle, J; Cahill, E; Caulfield, B; McCarthy Persson, U

    2010-01-01

    Horse rider ability has long been measured using horse performance, competition results and visual observation. Scientific methods of measuring rider ability on the flat are emerging such as measuring position angles and harmony of the horse-rider system. To date no research has quantified rider ability in show jumping. Kinematic analysis and motion sensors have been used in sports other than show jumping to measure the quality of motor control patterns in humans. The aim of this study was to quantify rider ability in show jumping using body-mounted IMUs. Preliminary results indicate that there are clear differences in experienced and novice riders during show jumping.

  20. Conservation Project Shows Substantial Reduction in Home Water Use

    Science.gov (United States)

    Sharpe, William E.; Smith, Donald

    1978-01-01

    Describes a water use study-conservation project conducted by the Washington Suburban Sanitary Commission in Maryland. Results show a significant decrease in the amount of water used by home customers over a ten-year period. (Author/MA)

  1. Enceladus Results

    Data.gov (United States)

    National Aeronautics and Space Administration — Here are some results from the Spectra Decomposition Algorithm on infrared spectral images of Saturn's moon Enceladus. Figure 1 is the spatial contribution of the...

  2. Show Horse Welfare: Horse Show Competitors' Understanding, Awareness, and Perceptions of Equine Welfare.

    Science.gov (United States)

    Voigt, Melissa A; Hiney, Kristina; Richardson, Jennifer C; Waite, Karen; Borron, Abigail; Brady, Colleen M

    2016-01-01

    The purpose of this study was to gain a better understanding of stock-type horse show competitors' understanding of welfare and level of concern for stock-type show horses' welfare. Data were collected through an online questionnaire that included questions relating to (a) interest and general understanding of horse welfare, (b) welfare concerns of the horse show industry and specifically the stock-type horse show industry, (c) decision-making influences, and (d) level of empathic characteristics. The majority of respondents indicated they agree or strongly agree that physical metrics should be a factor when assessing horse welfare, while fewer agreed that behavioral and mental metrics should be a factor. Respondent empathy levels were moderate to high and were positively correlated with the belief that mental and behavioral metrics should be a factor in assessing horse welfare. Respondents indicated the inhumane practices that most often occur at stock-type shows include excessive jerking on reins, excessive spurring, and induced excessive unnatural movement. Additionally, respondents indicated association rules, hired trainers, and hired riding instructors are the most influential regarding the decisions they make related to their horses' care and treatment.

  3. Snacking on Television: A Content Analysis of Adolescents’ Favorite Shows

    Science.gov (United States)

    Larson, Nicole I.; Gollust, Sarah E.; Neumark-Sztainer, Dianne

    2016-01-01

    Introduction Snacking is a complex behavior that may be influenced by entertainment media. Research suggests that snacking and unhealthy foods are commonly shown in programming that targets young audiences, but shows selected for study have been limited. We conducted a content analysis on shows that were named as favorites by adolescents to characterize portrayals of snacking on popular television. Methods A diverse sample of 2,130 adolescents (mean age, 14.3 y) listed 3 favorite television shows in a 2010 school-based survey. Three episodes each of the 25 most popular shows were coded for food-related content, including healthfulness, portion size, screen time use, setting, and social context. We also analyzed the characteristics of characters involved in eating incidents, the show type, and the show rating. We used χ2 tests, binomial tests, and multilevel regression models to compare incidence of snacks versus meals, the characteristics of those involved, and snacking across show characteristics. Results Almost half of food incidents on television shows were snacks. Snacks were significantly more likely than meals to be “mostly unhealthy” (69.3% vs 22.6%, P Sitcoms and shows rated for a youth audience were significantly more likely to portray snacking than were shows for adult audiences. Conclusion Media awareness and literacy programs should include foods and snacking behaviors among the issues they address. More healthful portrayals of food and dietary intake in entertainment shows’ content would create a healthier media environment for youth. PMID:27197079

  4. Dolphin shows and interaction programs: benefits for conservation education?

    Science.gov (United States)

    Miller, L J; Zeigler-Hill, V; Mellen, J; Koeppel, J; Greer, T; Kuczaj, S

    2013-01-01

    Dolphin shows and dolphin interaction programs are two types of education programs within zoological institutions used to educate visitors about dolphins and the marine environment. The current study examined the short- and long-term effects of these programs on visitors' conservation-related knowledge, attitude, and behavior. Participants of both dolphin shows and interaction programs demonstrated a significant short-term increase in knowledge, attitudes, and behavioral intentions. Three months following the experience, participants of both dolphin shows and interaction programs retained the knowledge learned during their experience and reported engaging in more conservation-related behaviors. Additionally, the number of dolphin shows attended in the past was a significant predictor of recent conservation-related behavior suggesting that repetition of these types of experiences may be important in inspiring people to conservation action. These results suggest that both dolphin shows and dolphin interaction programs can be an important part of a conservation education program for visitors of zoological facilities.

  5. Attitudes towards disability showed by future physical education teachers

    OpenAIRE

    Jorge Abellán Hernández

    2015-01-01

    The present paper aims to study the attitudes towards disability of future physical education teachers. For this purpose two questionnaires were administered and the results were compared by gender (male and female), the participants' experience in dealing with people with disabilities and the particants’ course level (third or fourth grade). The results show that students in the Minor in Physical Education have a very positive attitude towards disability. Men obtain a more positive attitude ...

  6. Reciprocal Ontological Models Show Indeterminism Comparable to Quantum Theory

    Science.gov (United States)

    Bandyopadhyay, Somshubhro; Banik, Manik; Bhattacharya, Some Sankar; Ghosh, Sibasish; Kar, Guruprasad; Mukherjee, Amit; Roy, Arup

    2016-12-01

    We show that within the class of ontological models due to Harrigan and Spekkens, those satisfying preparation-measurement reciprocity must allow indeterminism comparable to that in quantum theory. Our result implies that one can design quantum random number generator, for which it is impossible, even in principle, to construct a reciprocal deterministic model.

  7. Distributing and Showing Farmer Learning Videos in Bangladesh

    Science.gov (United States)

    Bentley, Jeffery W.; Van Mele, Paul; Harun-ar-Rashid, Md.; Krupnik, Timothy J.

    2016-01-01

    Purpose: To describe the results of showing farmer learning videos through different types of volunteers. Design/Methodology/Approach: Semi-structured interviews with volunteers from different occupational groups in Bangladesh, and a phone survey with 227 respondents. Findings: Each occupational group acted differently. Shop keepers, tillage…

  8. Reciprocal Ontological Models Show Indeterminism Comparable to Quantum Theory

    Science.gov (United States)

    Bandyopadhyay, Somshubhro; Banik, Manik; Bhattacharya, Some Sankar; Ghosh, Sibasish; Kar, Guruprasad; Mukherjee, Amit; Roy, Arup

    2017-02-01

    We show that within the class of ontological models due to Harrigan and Spekkens, those satisfying preparation-measurement reciprocity must allow indeterminism comparable to that in quantum theory. Our result implies that one can design quantum random number generator, for which it is impossible, even in principle, to construct a reciprocal deterministic model.

  9. Attitudes towards disability showed by future physical education teachers

    Directory of Open Access Journals (Sweden)

    Jorge Abellán Hernández

    2015-09-01

    Full Text Available The present paper aims to study the attitudes towards disability of future physical education teachers. For this purpose two questionnaires were administered and the results were compared by gender (male and female, the participants' experience in dealing with people with disabilities and the particants’ course level (third or fourth grade. The results show that students in the Minor in Physical Education have a very positive attitude towards disability. Men obtain a more positive attitude in RICE variable, also is observed the trend of the previous contact with people with disabilities positively affects attitudes towards disability. Finally higher values in CG variable will be obtained by students of fourth grade.

  10. Learning from a dive show in an aquarium setting

    Science.gov (United States)

    Walsh, Lori M.

    A study was conducted at an aquarium next to a theme park to understand information recalled from two versions of shows viewed at the largest display. The goal of this research was to determine if learning was enhanced by having a diver in water as the treatment group. This project focused on the knowledge recalled about shark and ray feeding adaptations, the information recalled about the mentioned conservation message about sustainable seafood and the potential of the two shows to make memorable experiences. During the project, 30 adult participants from each group were given a survey with five open-ended questions. Results suggest that the diver might distract from biological content information, or that the diver is such a novel element that it interferes with recall. While guests seemed to recall information about rays and sharks, the amount of information was not substantial. It appears that the diver does not affect content messaging but does impact whether guests attend to Seafood Watch messaging. The diver may have been so novel that the treatment group could not attend to the conservation message that was delivered, regardless of topic, or the control group recalled the message because the guests were not distracted by the diver or feeding. The absence of a diver seems to allow the guests to better attend to what is happening outside of the tank. While adding a diver increases photo opportunities and may bring guests to a show, the results seem to indicate that it does not significantly increase recall. The results of this study show that guests in a theme park setting can recall information from an educational program. Guests may not enter this hybrid aquarium with the intention of learning, but recall, one of the components in learning, does occur.

  11. Measuring Political Polarization: Twitter shows the two sides of Venezuela

    CERN Document Server

    Morales, A J; Losada, J C; Benito, R M

    2015-01-01

    We say that a population is perfectly polarized when divided in two groups of the same size and opposite opinions. In this paper, we propose a methodology to study and measure the emergence of polarization from social interactions. We begin by proposing a model to estimate opinions in which a minority of influential individuals propagate their opinions through a social network. The result of the model is an opinion probability density function. Next, we propose an index to quantify the extent to which the resulting distribution is polarized. Finally, we apply the proposed methodology to a Twitter conversation about the late Venezuelan president, Hugo Ch\\'avez, finding a good agreement between our results and offline data. Hence, we show that our methodology can detect different degrees of polarization, depending on the structure of the network.

  12. Deaf Individuals Show a Leftward Bias in Numerical Bisection.

    Science.gov (United States)

    Cattaneo, Zaira; Cecchetto, Carlo; Papagno, Costanza

    2016-01-01

    Consistent evidence suggests that deaf individuals conceive of numerical magnitude as a left-to-right-oriented mental number line, as typically observed in hearing individuals. When accessing this spatial representation of numbers, normally hearing individuals typically show an attentional bias to the left (pseudoneglect), resembling the attentional bias they show in physical space. Deaf individuals do not show pseudoneglect in representing external space, as assessed by a visual line bisection task. However, whether deaf individuals show attentional biases in representing numerical space has never been investigated before. Here we instructed groups of deaf and hearing individuals to quickly estimate (without calculating) the midpoint of a series of numerical intervals presented in ascending and descending order. Both hearing and deaf individuals were significantly biased toward lower numbers (i.e., the leftward side of the mental number line) in their estimations. Nonetheless, the underestimation bias was smaller in deaf individuals than in the hearing when bisecting pairs of numbers given in descending order. This result may depend on the use of different strategies by deaf and hearing participants or a less pronounced lateralization of deaf individuals in the control of spatial attention.

  13. Migraine patients consistently show abnormal vestibular bedside tests

    Directory of Open Access Journals (Sweden)

    Eliana Teixeira Maranhão

    2015-01-01

    Full Text Available Migraine and vertigo are common disorders, with lifetime prevalences of 16% and 7% respectively, and co-morbidity around 3.2%. Vestibular syndromes and dizziness occur more frequently in migraine patients. We investigated bedside clinical signs indicative of vestibular dysfunction in migraineurs.Objective To test the hypothesis that vestibulo-ocular reflex, vestibulo-spinal reflex and fall risk (FR responses as measured by 14 bedside tests are abnormal in migraineurs without vertigo, as compared with controls.Method Cross-sectional study including sixty individuals – thirty migraineurs, 25 women, 19-60 y-o; and 30 gender/age healthy paired controls.Results Migraineurs showed a tendency to perform worse in almost all tests, albeit only the Romberg tandem test was statistically different from controls. A combination of four abnormal tests better discriminated the two groups (93.3% specificity.Conclusion Migraine patients consistently showed abnormal vestibular bedside tests when compared with controls.

  14. Face and body recognition show similar improvement during childhood.

    Science.gov (United States)

    Bank, Samantha; Rhodes, Gillian; Read, Ainsley; Jeffery, Linda

    2015-09-01

    Adults are proficient in extracting identity cues from faces. This proficiency develops slowly during childhood, with performance not reaching adult levels until adolescence. Bodies are similar to faces in that they convey identity cues and rely on specialized perceptual mechanisms. However, it is currently unclear whether body recognition mirrors the slow development of face recognition during childhood. Recent evidence suggests that body recognition develops faster than face recognition. Here we measured body and face recognition in 6- and 10-year-old children and adults to determine whether these two skills show different amounts of improvement during childhood. We found no evidence that they do. Face and body recognition showed similar improvement with age, and children, like adults, were better at recognizing faces than bodies. These results suggest that the mechanisms of face and body memory mature at a similar rate or that improvement of more general cognitive and perceptual skills underlies improvement of both face and body recognition.

  15. PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.

    Science.gov (United States)

    Aboud, Asad A; Tidball, Andrew M; Kumar, Kevin K; Neely, M Diana; Han, Bingying; Ess, Kevin C; Hong, Charles C; Erikson, Keith M; Hedera, Peter; Bowman, Aaron B

    2015-01-01

    Poorly-defined interactions between environmental and genetic risk factors underlie Parkinson's disease (PD) etiology. Here we tested the hypothesis that human stem cell derived forebrain neuroprogenitors from patients with known familial risk for early onset PD will exhibit enhanced sensitivity to PD environmental risk factors compared to healthy control subjects without a family history of PD. Two male siblings (SM and PM) with biallelic loss-of-function mutations in PARK2 were identified. Human induced pluripotent stem cells (hiPSCs) from SM, PM, and four control subjects with no known family histories of PD or related neurodegenerative diseases were utilized. We tested the hypothesis that hiPSC-derived neuroprogenitors from patients with PARK2 mutations would show heightened cell death, mitochondrial dysfunction, and reactive oxygen species generation compared to control cells as a result of exposure to heavy metals (PD environmental risk factors). We report that PARK2 mutant neuroprogenitors showed increased cytotoxicity with copper (Cu) and cadmium (Cd) exposure but not manganese (Mn) or methyl mercury (MeHg) relative to control neuroprogenitors. PARK2 mutant neuroprogenitors also showed a substantial increase in mitochondrial fragmentation, initial ROS generation, and loss of mitochondrial membrane potential following Cu exposure. Our data substantiate Cu exposure as an environmental risk factor for PD. Furthermore, we report a shift in the lowest observable effect level (LOEL) for greater sensitivity to Cu-dependent mitochondrial dysfunction in patients SM and PM relative to controls, correlating with their increased genetic risk for PD.

  16. The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability

    Science.gov (United States)

    Yi, Zong-Chun; Li, Xiao-Fei; Wang, Yan; Wang, Jie; Sun, Yan; Zhuang, Feng-Yuan

    2011-06-01

    The budding yeast Saccharomyces cerevisiae has been proposed as an ideal model organism for clarifying the biological effects caused by spaceflight conditions. The postmitotic S. cerevisiae cells onboard Practice eight recoverable satellite were subjected to spaceflight for 15 days. After recovery, the viability, the glycogen content, the activities of carbohydrate metabolism enzymes, the DNA content and the lipid peroxidation level in yeast cells were analyzed. The viability of the postmitotic yeast cells after spaceflight showed a three-fold increase as compared with that of the ground control cells. Compared to the ground control cells, the lipid peroxidation level in the spaceflight yeast cells markedly decreased. The spaceflight yeast cells also showed an increase in G2/M cell population and a decrease in Sub-G1 cell population. The glycogen content and the activities of hexokinase and succinate dehydrogenase significantly decreased in the yeast cells after spaceflight. In contrast, the activity of malate dehydrogenase showed an obvious increase after spaceflight. These results suggested that microgravity or spaceflight could promote the survival of postmitotic S. cerevisiae cells through regulating carbohydrate metabolism, ROS level and cell cycle progression.

  17. Phytoceramide Shows Neuroprotection and Ameliorates Scopolamine-Induced Memory Impairment

    Directory of Open Access Journals (Sweden)

    Seikwan Oh

    2011-10-01

    Full Text Available The function and the role phytoceramide (PCER and phytosphingosine (PSO in the central nervous system has not been well studied. This study was aimed at investigating the possible roles of PCER and PSO in glutamate-induced neurotoxicity in cultured neuronal cells and memory function in mice. Phytoceramide showed neuro-protective activity in the glutamate-induced toxicity in cultured cortical neuronal cells. Neither phytosphingosine nor tetraacetylphytosphingosine (TAPS showed neuroproective effects in neuronal cells. PCER (50 mg/kg, p.o. recovered the scopolamine-induced reduction in step-through latency in the passive avoidance test; however, PSO did not modulate memory function on this task. The ameliorating effects of PCER on spatial memory were confirmed by the Morris water maze test. In conclusion, through behavioral and neurochemical experimental results, it was demonstrated that central administration of PCER produces amelioration of memory impairment. These results suggest that PCER plays an important role in neuroprotection and memory enhancement and PCER could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.

  18. Highly reflective reasoners show no signs of belief inhibition.

    Science.gov (United States)

    Svedholm-Häkkinen, Annika M

    2015-01-01

    The processes underlying individual differences in reasoning performance are not entirely understood. What do people who do well on reasoning tasks where beliefs and logic conflict do differently from other people? Because abundant evidence shows that even poorer reasoners detect these conflicts, it has been suggested that individual differences in reasoning performance arise from inhibition failures later in the reasoning process. The present paper argues that a minority of highly skilled reasoners may deviate from this general reasoning process from an early stage. Two studies investigated signs of belief inhibition using a lexical access paradigm (Study 1) and a negative priming paradigm (Study 2). Study 1 showed that while other people exhibited signs of belief inhibition following a belief-logic conflict, people with the highest disposition for cognitive reflection did not. In Study 2, this finding was replicated and similar results were also obtained when comparing groups with higher and lower general cognitive ability. Two possible explanations are discussed. The reasoners with a highly reflective cognitive style or high general cognitive ability may have engaged and inhibited belief processing but if so, they may have been exceptionally efficient at recovering from it, wherefore no belief inhibition effects were found. An alternative account is that these reasoners started Type 2 processing directly, without first engaging in and then inhibiting belief-based processing. Under either explanation, the results indicate that individual differences in reasoning may partly arise from differences that occur early in the reasoning process.

  19. Dogs show left facial lateralization upon reunion with their owners.

    Science.gov (United States)

    Nagasawa, Miho; Kawai, Emi; Mogi, Kazutaka; Kikusui, Takefumi

    2013-09-01

    Domestic dogs demonstrate behavioral laterality in response to emotional stimuli; those responses include tail wagging and head turning. The dog is the species with the closest relationship to humans; dogs can express strong social emotions (e.g., attachment and separation anxiety) to specific persons, such as their owners. In this study, we examined whether dogs demonstrate more facial laterality when reunited with their owners than when they encounter an unfamiliar person in an unfamiliar situation. We also examined whether the observed laterality was specific to positive social stimuli (i.e., the owner) or a general response to nonsocial positive stimuli (i.e., toys). The dogs' facial expressions were recorded by a high-speed video camera during the presentation of emotional stimuli and the acceleration rates of parts of their faces were analyzed. The results showed that the left eyebrow moved more when the owner was present than at baseline. No bias in terms of eyebrow movement was observed when the dogs saw attractive toys. These results suggest that dogs show facial laterality in response to emotional stimuli. This laterality was specific to social stimuli, probably reflecting the dog's attachment to the owner.

  20. SNA Releases Back to School Nutrition Trends Report: Results Show What Schools Are Doing to Increase Healthy Options for Kids

    Science.gov (United States)

    Curriculum Review, 2008

    2008-01-01

    This article talks about the School Nutrition Association's 2008 Back to School Nutrition Trends Report that was released on August 19. According to the report, the trend towards more healthful school meal choices continues this fall with district nutrition programs emphasizing whole grains, fruits, and vegetables while cutting back on trans fats,…

  1. Map showing locations of damaging landslides in Napa County, California, resulting from 1997-98 El Nino rainstorms

    Science.gov (United States)

    Godt, Jonathan W.; Savage, William Z.; Wilson, Raymond C.

    1999-01-01

    Heavy rainfall associated with a strong El Nino caused over $150 million in landslide damage in the 10-county San Francisco Bay region during the winter and spring of 1998. A team of USGS scientists collected information on landslide locations and damage costs. Napa County was relatively unaffected in comparison to other counties in the region with approximately $1.1 million in damages assessed.

  2. Warthin-starry Silver Method Showing Particulate Matter in Macrophage

    Institute of Scientific and Technical Information of China (English)

    HONG-GANG LIU

    2008-01-01

    Objective To verify whether Warthin-Starry(WS)silver method could detect the air particulate matter(PM)/dust particles(Ps)located within the macrophages in situ. Methods There were 26 antopsy cases that resulted from cerebral hemorrhage(group A),silicosis(group B),and fetal death during pregnancy(group C).Samples were collected separately and serial sections were prepared from the lungs and lymph nodes and stained with hematoxylin and eosin(HE),WS silver,immunohistochemistry of CD68.Furthermore,ultrathin sections were taken from the WS positive serial sections of groups A and B.Ps were observed under a transmission electron microscope(TEM)and the elements of Ps were measured by X-ray spectrum analysis(X-RSA).Results In both groups A and B,WS staining was positive for the larger and fine Ps,the so called"dust cells",but HE staining Was almost negative for fine Ps.In group C,no larger or fine Ps were found.Immunohistochemical staining of CD68 certified that the"dust cells"containing Ps were macrophages.The results of TEM and X-RSA proved that the structure and elements of Ps belonged to PM indeed.Conclusion WS staining is a better than HE staining in showing the location of PM within macrophages.

  3. Food Safety Not Always on Menu of TV Cooking Shows

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_161980.html Food Safety Not Always on Menu of TV Cooking Shows ... shows. They also noted whether the shows mentioned food safety. The findings were published in the November-December ...

  4. 32 CFR 552.78 - “Show cause” hearing.

    Science.gov (United States)

    2010-07-01

    ....78 “Show cause” hearing. Before suspending the solicitation privilege, the company and the agent will have a chance to show cause why the action should not be taken. “Show cause” is an opportunity for...

  5. Tropical Aquatic Archaea Show Environment-Specific Community Composition

    Science.gov (United States)

    Silveira, Cynthia B.; Cardoso, Alexander M.; Coutinho, Felipe H.; Lima, Joyce L.; Pinto, Leonardo H.; Albano, Rodolpho M.; Clementino, Maysa M.; Martins, Orlando B.; Vieira, Ricardo P.

    2013-01-01

    The Archaea domain is ubiquitously distributed and extremely diverse, however, environmental factors that shape archaeal community structure are not well known. Aquatic environments, including the water column and sediments harbor many new uncultured archaeal species from which metabolic and ecological roles remain elusive. Some environments are especially neglected in terms of archaeal diversity, as is the case of pristine tropical areas. Here we investigate the archaeal composition in marine and freshwater systems from Ilha Grande, a South Atlantic tropical environment. All sampled habitats showed high archaeal diversity. No OTUs were shared between freshwater, marine and mangrove sediment samples, yet these environments are interconnected and geographically close, indicating environment-specific community structuring. Group II Euryarchaeota was the main clade in marine samples, while the new putative phylum Thaumarchaeota and LDS/RCV Euryarchaeota dominated freshwaters. Group III Euryarchaeota, a rare clade, was also retrieved in reasonable abundance in marine samples. The archaeal community from mangrove sediments was composed mainly by members of mesophilic Crenarchaeota and by a distinct clade forming a sister-group to Crenarchaeota and Thaumarchaeota. Our results show strong environment-specific community structuring in tropical aquatic Archaea, as previously seen for Bacteria. PMID:24086729

  6. Intracerebral metastasis showing restricted diffusion: Correlation with histopathologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Duygulu, G. [Radiology Department, Ege University Medicine School, Izmir (Turkey); Ovali, G. Yilmaz [Radiology Department, Celal Bayar University Medicine School, Manisa (Turkey)], E-mail: gulgun.yilmaz@bayar.edu.tr; Calli, C.; Kitis, O.; Yuenten, N. [Radiology Department, Ege University Medicine School, Izmir (Turkey); Akalin, T. [Pathology Department, Ege University Medicine School, Izmir (Turkey); Islekel, S. [Neurosurgery Department, Ege University Medicine School, Izmir (Turkey)

    2010-04-15

    Objective: We aimed to detect the frequency of restricted diffusion in intracerebral metastases and to find whether there is correlation between the primary tumor pathology and diffusion-weighted MR imaging (DWI) findings of these metastases. Material and methods: 87 patients with intracerebral metastases were examined with routine MR imaging and DWI. 11 hemorrhagic metastatic lesions were excluded. The routine MR imaging included three plans before and after contrast enhancement. The DWI was performed with spin-echo EPI sequence with three b values (0, 500 and 1000), and ADC maps were calculated. 76 patients with metastases were grouped according to primary tumor histology and the ratios of restricted diffusion were calculated according to these groups. ADCmin values were measured within the solid components of the tumors and the ratio of metastases with restricted diffusion to that which do not show restricted diffusion were calculated. Fisher's exact and Mann-Whitney U tests were used for the statistical analysis. Results: Restricted diffusion was observed in a total of 15 metastatic lesions (19, 7%). Primary malignancy was lung carcinoma in 10 of these cases (66, 6%) (5 small cell carcinoma, 5 non-small cell carcinoma), and breast carcinoma in three cases (20%). Colon carcinoma and testicular teratocarcinoma were the other two primary tumors in which restricted diffusion in metastasis was detected. There was no statistical significant difference between the primary pathology groups which showed restricted diffusion (p > 0.05). ADCmin values of solid components of the metastasis with restricted diffusion and other metastasis without restricted diffusion also showed no significant statistical difference (0.72 {+-} 0.16 x 10{sup -3} mm{sup 2}/s and 0.78 {+-} 21 x 10{sup -3} mm{sup 2}/s respectively) (p = 0.325). Conclusion: Detection of restricted diffusion on DWI in intracerebral metastasis is not rare, particularly if the primary tumor is lung or breast

  7. PROTOTIPE VIDEO EDITOR DENGAN MENGGUNAKAN DIRECT X DAN DIRECT SHOW

    Directory of Open Access Journals (Sweden)

    Djoni Haryadi Setiabudi

    2004-01-01

    Full Text Available Technology development had given people the chance to capture their memorable moments in video format. A high quality digital video is a result of a good editing process. Which in turn, arise the new need of an editor application. In accordance to the problem, here the process of making a simple application for video editing needs. The application development use the programming techniques often applied in multimedia applications, especially video. First part of the application will begin with the video file compression and decompression, then we'll step into the editing part of the digital video file. Furthermore, the application also equipped with the facilities needed for the editing processes. The application made with Microsoft Visual C++ with DirectX technology, particularly DirectShow. The application provides basic facilities that will help the editing process of a digital video file. The application will produce an AVI format file after the editing process is finished. Through the testing process of this application shows the ability of this application to do the 'cut' and 'insert' of video files in AVI, MPEG, MPG and DAT formats. The 'cut' and 'insert' process only can be done in static order. Further, the aplication also provide the effects facility for transition process in each clip. Lastly, the process of saving the new edited video file in AVI format from the application. Abstract in Bahasa Indonesia : Perkembangan teknologi memberi kesempatan masyarakat untuk mengabadikan saat - saat yang penting menggunakan video. Pembentukan video digital yang baik membutuhkan proses editing yang baik pula. Untuk melakukan proses editing video digital dibutuhkan program editor. Berdasarkan permasalahan diatas maka pada penelitian ini dibuat prototipe editor sederhana untuk video digital. Pembuatan aplikasi memakai teknik pemrograman di bidang multimedia, khususnya video. Perencanaan dalam pembuatan aplikasi tersebut dimulai dengan pembentukan

  8. "The George Lopez Show": The Same Old Hispano?

    Science.gov (United States)

    Markert, John

    2007-01-01

    "The George Lopez Show" is the first successful television show with a Latino in a leading role that features Hispanic material since Freddie Prinze's thirty-year-old sitcom, "Chico and the Man." This study seeks to assess how Latinos are presented on "The George Lopez Show." A content analysis reveals that the show perpetuates some of the…

  9. 21 CFR 1314.150 - Order To show cause.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Order To show cause. 1314.150 Section 1314.150... CHEMICAL PRODUCTS Order to Show Cause § 1314.150 Order To show cause. (a) If, upon information gathered by... upon the regulated seller or distributor an order to show cause why the regulated seller or...

  10. 29 CFR 34.41 - Notice to Show Cause.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Notice to Show Cause. 34.41 Section 34.41 Labor Office of... Show Cause. (a) The Director may issue a Notice to Show Cause to a recipient failing to comply with the... compliance review. (b) The Notice to Show Cause shall contain: (1) A description of the violation and...

  11. Crack Repair in Aerospace Aluminum Alloy Panels by Cold Spray

    Science.gov (United States)

    Cavaliere, P.; Silvello, A.

    2017-02-01

    The cold-spray process has recently been recognized as a very useful tool for repairing metallic sheets, achieving desired adhesion strengths when employing optimal combinations of material process parameters. We present herein the possibility of repairing cracks in aluminum sheets by cold spray. A 2099 aluminum alloy panel with a surface 30° V notch was repaired by cold spraying of 2198 and 7075 aluminum alloy powders. The crack behavior of V-notched sheets subjected to bending loading was studied by finite-element modeling (FEM) and mechanical experiments. The simulations and mechanical results showed good agreement, revealing a remarkable K factor reduction, and a consequent reduction in crack nucleation and growth velocity. The results enable prediction of the failure initiation locus in the case of repaired panels subjected to bending loading and deformation. The stress concentration was quantified to show how the residual stress field and failure are affected by the mechanical properties of the sprayed materials and by the geometrical and mechanical properties of the interface. It was demonstrated that the crack resistance increases more than sevenfold in the case of repair using AA2198 and that cold-spray repair can contribute to increased global fatigue life of cracked structures.

  12. Remembering Operación Triunfo: a Latin Music Reality Show in the Era of Talent Shows

    Directory of Open Access Journals (Sweden)

    Paola Savini

    2016-08-01

    Full Text Available The music format Operación Triunfo (2001–2011, which aired on RTVE for the first time in 2001, started as a television (TV and musical success in Spain and today is one of the most famous shows around the world as well as an incredible socio-economic phenomenon in Spanish TV. This paper describes the format concept and results. Both commercial and social aspects are introduced to understand why, after 15 years, it is remembered with nostalgia and remains a shining example of a good communication project and a perfect balance between the global and the local, despite the lack of great success in the following years in Spain and abroad.

  13. 21 CFR 1301.37 - Order to show cause.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Order to show cause. 1301.37 Section 1301.37 Food... Suspension of Registration § 1301.37 Order to show cause. (a) If, upon examination of the application for... Administrator shall serve upon the applicant an order to show cause why the registration should not be...

  14. 47 CFR 1.701 - Show cause orders.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Show cause orders. 1.701 Section 1.701..., and Reports Involving Common Carriers General § 1.701 Show cause orders. (a) The Commission may... order to show cause. The order shall contain a statement of the particulars and matters concerning...

  15. 21 CFR 1309.46 - Order to show cause.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Order to show cause. 1309.46 Section 1309.46 Food... Or Suspension of Registration § 1309.46 Order to show cause. (a) If, upon examination of the... upon the applicant an order to show cause why the application for registration should not be denied....

  16. 46 CFR 502.66 - Order to show cause.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Order to show cause. 502.66 Section 502.66 Shipping... Proceedings; Pleadings; Motions; Replies § 502.66 Order to show cause. The Commission may institute a proceeding by order to show cause. The order shall be served upon all persons named therein, shall...

  17. 34 CFR 300.194 - Show cause hearing.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Show cause hearing. 300.194 Section 300.194 Education... DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.194 Show cause hearing. (a) If a show cause hearing is requested, the Secretary— (1) Notifies the SEA and affected LEA or other...

  18. 41 CFR 60-1.28 - Show cause notices.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notices. 60-1... Procedure § 60-1.28 Show cause notices. When the Deputy Assistant Secretary has reasonable cause to believe... contractor to show cause, within 30 days, why monitoring, enforcement proceedings or other appropriate...

  19. 10 CFR 590.401 - Orders to show cause.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Orders to show cause. 590.401 Section 590.401 Energy... WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Opinions and Orders § 590.401 Orders to show cause... exportation of natural gas over which FE has jurisdiction. Any show cause order issued shall identify...

  20. 25 CFR 141.56 - Show cause procedures.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Show cause procedures. 141.56 Section 141.56 Indians... NAVAJO, HOPI AND ZUNI RESERVATIONS Enforcement Powers, Procedures and Remedies § 141.56 Show cause... from the date of receipt of notice in which to show cause why the contemplated remedial action...

  1. Human-directed social behaviour in dogs shows significant heritability.

    Science.gov (United States)

    Persson, M E; Roth, L S V; Johnsson, M; Wright, D; Jensen, P

    2015-04-01

    Through domestication and co-evolution with humans, dogs have developed abilities to attract human attention, e.g. in a manner of seeking assistance when faced with a problem solving task. The aims of this study were to investigate within breed variation in human-directed contact seeking in dogs and to estimate its genetic basis. To do this, 498 research beagles, bred and kept under standardized conditions, were tested in an unsolvable problem task. Contact seeking behaviours recorded included both eye contact and physical interactions. Behavioural data was summarized through a principal component analysis, resulting in four components: test interactions, social interactions, eye contact and physical contact. Females scored significantly higher on social interactions and physical contact and age had an effect on eye contact scores. Narrow sense heritabilities (h(2) ) of the two largest components were estimated at 0.32 and 0.23 but were not significant for the last two components. These results show that within the studied dog population, behavioural variation in human-directed social behaviours was sex dependent and that the utilization of eye contact seeking increased with age and experience. Hence, heritability estimates indicate a significant genetic contribution to the variation found in human-directed social interactions, suggesting that social skills in dogs have a genetic basis, but can also be shaped and enhanced through individual experiences. This research gives the opportunity to further investigate the genetics behind dogs' social skills, which could also play a significant part into research on human social disorders such as autism.

  2. Plan Merging: Experimental results

    NARCIS (Netherlands)

    De Weerdt, M.M.; Van der Krogt, R.P.J.; Zutt, J.

    2003-01-01

    In this paper we discuss the results of a plan merging algorithm. This algorithm coordinates the plans of multiple, autonomous agents, each able to independently find a plan. This algorithm is evaluated using realistic data from a taxi company. We show that when we allow passengers to be a few minut

  3. Winter wren populations show adaptation to local climate.

    Science.gov (United States)

    Morrison, Catriona A; Robinson, Robert A; Pearce-Higgins, James W

    2016-06-01

    Most studies of evolutionary responses to climate change have focused on phenological responses to warming, and provide only weak evidence for evolutionary adaptation. This could be because phenological changes are more weakly linked to fitness than more direct mechanisms of climate change impacts, such as selective mortality during extreme weather events which have immediate fitness consequences for the individuals involved. Studies examining these other mechanisms may be more likely to show evidence for evolutionary adaptation. To test this, we quantify regional population responses of a small resident passerine (winter wren Troglodytes troglodytes) to a measure of winter severity (number of frost days). Annual population growth rate was consistently negatively correlated with this measure, but the point at which different populations achieved stability (λ = 1) varied across regions and was closely correlated with the historic average number of frost days, providing strong evidence for local adaptation. Despite this, regional variation in abundance remained negatively related to the regional mean number of winter frost days, potentially as a result of a time-lag in the rate of evolutionary response to climate change. As expected from Bergmann's rule, individual wrens were heavier in colder regions, suggesting that local adaptation may be mediated through body size. However, there was no evidence for selective mortality of small individuals in cold years, with annual variation in mean body size uncorrelated with the number of winter frost days, so the extent to which local adaptation occurs through changes in body size, or another mechanism remains uncertain.

  4. Insertion Sequences show diverse recent activities in Cyanobacteria and Archaea

    Directory of Open Access Journals (Sweden)

    Xu Ying

    2008-01-01

    Full Text Available Abstract Background Mobile genetic elements (MGEs play an essential role in genome rearrangement and evolution, and are widely used as an important genetic tool. Results In this article, we present genetic maps of recently active Insertion Sequence (IS elements, the simplest form of MGEs, for all sequenced cyanobacteria and archaea, predicted based on the previously identified ~1,500 IS elements. Our predicted IS maps are consistent with the NCBI annotations of the IS elements. By linking the predicted IS elements to various characteristics of the organisms under study and the organism's living conditions, we found that (a the activities of IS elements heavily depend on the environments where the host organisms live; (b the number of recently active IS elements in a genome tends to increase with the genome size; (c the flanking regions of the recently active IS elements are significantly enriched with genes encoding DNA binding factors, transporters and enzymes; and (d IS movements show no tendency to disrupt operonic structures. Conclusion This is the first genome-scale maps of IS elements with detailed structural information on the sequence level. These genetic maps of recently active IS elements and the several interesting observations would help to improve our understanding of how IS elements proliferate and how they are involved in the evolution of the host genomes.

  5. Limb proportions show developmental plasticity in response to embryo movement

    Science.gov (United States)

    Pollard, A. S.; Charlton, B. G.; Hutchinson, J. R.; Gustafsson, T.; McGonnell, I. M.; Timmons, J. A.; Pitsillides, A. A.

    2017-01-01

    Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment during prenatal development. The developing skeleton experiences mechanical loading resulting from embryo movement. We tested the hypothesis that environmentally-induced changes in prenatal movement influence embryonic limb growth to alter proportions. We show that incubation temperature influences motility and limb bone growth in West African Dwarf crocodiles, producing altered limb proportions which may, influence post-hatching performance. Pharmacological immobilisation of embryonic chickens revealed that altered motility, independent of temperature, may underpin this growth regulation. Use of the chick also allowed us to merge histological, immunochemical and cell proliferation labelling studies to evaluate changes in growth plate organisation, and unbiased array profiling to identify specific cellular and transcriptional targets of embryo movement. This disclosed that movement alters limb proportions and regulates chondrocyte proliferation in only specific growth plates. This selective targeting is related to intrinsic mTOR (mechanistic target of rapamycin) pathway activity in individual growth plates. Our findings provide new insights into how environmental factors can be integrated to influence cellular activity in growing bones and ultimately gross limb morphology, to generate phenotypic variation during prenatal development. PMID:28165010

  6. Effects of TV Crime Shows on Behavioural Development of Children

    OpenAIRE

    Abdullah Mudassar; Abd Rahman Nik Adzrieman B.

    2017-01-01

    Television crime dramas and shows are very popular all over the world. This popularity is not bound to a certain age group, rather all the TV viewers like these shows very much. Like other countries, dozens of TV channels are telecasting these crime shows in Pakistan. Furthermore, few of the channels telecast crime shows at prime time which attests the popularity of such genre. Some of the media contents behave in morally disputed ways. The crime depictions as re-enactments of TV crime shows ...

  7. Branding through trade shows in the automotive industry

    OpenAIRE

    Narui, Jahan

    2013-01-01

    The automotive industry is a major global industry with a great history of exhibitions. As trade shows are getting more attention within studies, the same is not the case for automotive trade shows. Noteworthy, automotive trade shows emphasize non-selling roles such as image-building. This paper seeks to investigate image-building purposes of exhibiting automotive companies using integrated marketing communications (IMC). Data has been gathered from four participating companies in the Geneva ...

  8. China Sport Show: More Professional and on a Larger Scale

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ The 26th China Sport Show will be held in New China International Exhibition Center, Beijing, from May 20 to 23, 2010. As a fast-growing sport show, it has been playing an important role in promoting the development of Chinese brands and the cooperation of the enterprises. This year, the sport show is welcoming over 1000 exhibitors and 50,000 trade visitors from over 60 countries and regions.

  9. 34 CFR 300.193 - Request to show cause.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Request to show cause. 300.193 Section 300.193... show cause. An SEA, LEA or other public agency in receipt of a notice under § 300.192 that seeks an opportunity to show cause why a by-pass should not be implemented must submit a written request for a...

  10. Uudised : Otsman taas Riias show'l. Rokkstaarist ministriks

    Index Scriptorium Estoniae

    2007-01-01

    Drag-kabareeartist Erkki Otsman esineb detsembris Riias "Sapnu Fabrikas" toimuval jõulu-show'l. Austraalia rokkansambli Midnight Oil endine laulja Peter Garrett nimetati valitsuse keskkonnaministriks

  11. A Study on Person Deixis Used in TV Talk Show

    Institute of Scientific and Technical Information of China (English)

    肖晓

    2014-01-01

    Deixis means“pointing” via language. There are many scholars who study person deixis in different discourses. However, few of them have analyzed person deixis used in TV talk show, which is more popular in our daily life. TV talk show is an important face-to-face conversation in which the participants use some person deixis to reach certain goal. This thesis studies the person deixis used in TV talk show especial y three types of unconventional usage of person deixis in the TV talk show discourse.

  12. Can recurrence networks show small-world property?

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, Rinku, E-mail: rinku.jacob.vallanat@gmail.com [Department of Physics, The Cochin College, Cochin, 682002 (India); Harikrishnan, K.P., E-mail: kp_hk2002@yahoo.co.in [Department of Physics, The Cochin College, Cochin, 682002 (India); Misra, R., E-mail: rmisra@iucaa.in [Inter University Centre for Astronomy and Astrophysics, Pune, 411007 (India); Ambika, G., E-mail: g.ambika@iiserpune.ac.in [Indian Institute of Science Education and Research, Pune, 411008 (India)

    2016-08-12

    Recurrence networks are complex networks, constructed from time series data, having several practical applications. Though their properties when constructed with the threshold value ϵ chosen at or just above the percolation threshold of the network are quite well understood, what happens as the threshold increases beyond the usual operational window is still not clear from a complex network perspective. The present Letter is focused mainly on the network properties at intermediate-to-large values of the recurrence threshold, for which no systematic study has been performed so far. We argue, with numerical support, that recurrence networks constructed from chaotic attractors with ϵ equal to the usual recurrence threshold or slightly above cannot, in general, show small-world property. However, if the threshold is further increased, the recurrence network topology initially changes to a small-world structure and finally to that of a classical random graph as the threshold approaches the size of the strange attractor. - Highlights: • Properties of recurrence networks at intermediate-to-large values of recurrence threshold are analyzed from a complex network perspective. • Using a combined plot of characteristic path length and clustering coefficient, it is shown that the recurrence network constructed with recurrence threshold equal to or just above the percolation threshold cannot, in general, display small-world property. • As the recurrence threshold is increased from its usual operational window, the resulting network makes a smooth transition initially to a small-world network for an intermediate range of thresholds and finally to the classical random graph as the threshold becomes comparable to the size of the attractor.

  13. Computer Slide Shows: A Trap for Bad Teaching

    Science.gov (United States)

    Klemm, W. R.

    2007-01-01

    Slide shows presented with software such as PowerPoint or WordPerfect Presentations can trap instructors into bad teaching practices. Research on memory suggests that slide-show instruction can actually be less effective than traditional lecturing when the teacher uses a blackboard or overhead projector. The author proposes a model of classroom…

  14. 9 CFR 354.247 - Table showing types of materials.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Table showing types of materials. 354... Sanitary Conditions and Precautions Against Contamination of Products § 354.247 Table showing types of materials. Equipment, utensils, and facilities Iron Stainless steel and monel metal Aluminum Galvanized...

  15. The Presentation of Science in Everyday Life: The Science Show

    Science.gov (United States)

    Watermeyer, Richard

    2013-01-01

    This paper constitutes a case-study of the "science show" model of public engagement employed by a company of science communicators focused on the popularization of science, technology, engineering and mathematics (STEM) subject disciplines with learner constituencies. It examines the potential of the science show to foster the interest…

  16. Effects of TV Crime Shows on Behavioural Development of Children

    Directory of Open Access Journals (Sweden)

    Abdullah Mudassar

    2017-01-01

    Full Text Available Television crime dramas and shows are very popular all over the world. This popularity is not bound to a certain age group, rather all the TV viewers like these shows very much. Like other countries, dozens of TV channels are telecasting these crime shows in Pakistan. Furthermore, few of the channels telecast crime shows at prime time which attests the popularity of such genre. Some of the media contents behave in morally disputed ways. The crime depictions as re-enactments of TV crime shows are questionable in the field of research signifying diverse cultural contexts. A large number of people are habitual to watch these shows, which may probably come out with negative behavioural outcomes. Especially the children who are at their behavioural developmental phase; are more susceptible to adopt negative behavioural leanings. In this research effort, introduction and detail of TV crime shows in Pakistan are provided, the literature concerning “media as risk factor“ in children development is discussed, and relevant theories inferences are deliberated.it was found that media has powerful role in behaviour formulating of children and violence media portrayal (TV crime shows may appear with grave concerns. Previous scientific literature was reviewed to find and discuss the problem in hand. In the research effort, the literature review provides research propositions to explore further dimensions to TV crime shows’ effects and possible negative or positive behavioural outcomes in children behaviour.

  17. 41 CFR 60-300.64 - Show cause notices.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notices. 60... VETERANS General Enforcement and Complaint Procedures § 60-300.64 Show cause notices. When the Deputy Assistant Secretary has reasonable cause to believe that the contractor has violated the Act or this...

  18. 14 CFR 303.44 - Show cause proceedings.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Show cause proceedings. 303.44 Section 303... cause proceedings. If the Assistant Secretary determines that an application, or review of a previously granted application, will be considered in a show cause proceeding, a tentative decision shall be...

  19. 18 CFR 808.15 - Show cause proceeding.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Show cause proceeding... HEARINGS AND ENFORCEMENT ACTIONS Compliance and Enforcement § 808.15 Show cause proceeding. (a) The... cause why a penalty should not be assessed in accordance with the provisions of this chapter and...

  20. 41 CFR 60-250.64 - Show cause notices.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notices. 60... VETERANS General Enforcement and Complaint Procedures § 60-250.64 Show cause notices. When the Deputy Assistant Secretary has reasonable cause to believe that the contractor has violated the Act or this...

  1. 16 CFR 5.57 - Order to show cause.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Order to show cause. 5.57 Section 5.57... CONDUCT Disciplinary Actions Concerning Postemployment Conflict of Interest § 5.57 Order to show cause. (a) Upon a Commission determination that there exists reasonable cause to believe a former...

  2. 41 CFR 60-4.8 - Show cause notice.

    Science.gov (United States)

    2010-07-01

    ... cause which shall contain the items specified in paragraphs (i) through (iv) of 41 CFR 60-2.2(c)(1). If... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notice. 60-4.8...-CONSTRUCTION CONTRACTORS-AFFIRMATIVE ACTION REQUIREMENTS § 60-4.8 Show cause notice. If an investigation...

  3. 14 CFR 314.14 - Show-cause order.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Show-cause order. 314.14 Section 314.14... REGULATIONS EMPLOYEE PROTECTION PROGRAM Determination of Qualifying Dislocation § 314.14 Show-cause order. When the Department makes a preliminary determination of whether the major cause of the bankruptcy...

  4. 10 CFR 110.62 - Order to show cause.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Order to show cause. 110.62 Section 110.62 Energy NUCLEAR... Enforcement § 110.62 Order to show cause. (a) In response to an alleged violation, described in § 110.60, the... cause: (1) Stating the alleged violation and proposed enforcement action; and (2) Informing the...

  5. 41 CFR 60-741.64 - Show cause notices.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Show cause notices. 60... INDIVIDUALS WITH DISABILITIES General Enforcement and Complaint Procedures § 60-741.64 Show cause notices. When the Deputy Assistant Secretary has reasonable cause to believe that the contractor has...

  6. The Daily Show with Jon Stewart: Part 2

    Science.gov (United States)

    Trier, James

    2008-01-01

    "The Daily Show With Jon Stewart" is one of the best critical literacy programs on television, and in this Media Literacy column the author suggests ways that teachers can use video clips from the show in their classrooms. (For Part 1, see EJ784683.)

  7. "The Daily Show with Jon Stewart": Part 1

    Science.gov (United States)

    Trier, James

    2008-01-01

    Comedy Central's popular program "The Daily Show With Jon Stewart" is the best critical media literacy program on television, and it can be used in valuable ways in the classroom as part of a media literacy pedagogy. This Media Literacy column provides an overview of the show and its accompanying website and considers ways it might be used in the…

  8. TV Talk: Instant Classroom Celebrities With TV Game Shows

    Science.gov (United States)

    Sheppard, Marti

    1977-01-01

    Suggests some learning activities that can be used to capitalize on the popularity of TV game shows so that students can build their learning skills. These game show formats can also strengthen and reinforce many areas of the elementary curriculum. (Author/RK)

  9. TV shows on Light Pollution Education for the Public

    Science.gov (United States)

    Grigore, Valentin

    2015-03-01

    TV shows have the biggest impact for the public, so we can use them to inform and educate the public about light pollution and the importance of the dark sky for humanity and for the contemporary society. Some examples used in the TV show Us and the Sky at Columna TV, Romania, are presented.

  10. 47 CFR 73.33 - Antenna systems; showing required.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Antenna systems; showing required. 73.33... RADIO BROADCAST SERVICES AM Broadcast Stations § 73.33 Antenna systems; showing required. (a) An application for authority to install a broadcast antenna shall specify a definite site and include...

  11. ShowFlow: A practical interface for groundwater modeling

    Energy Technology Data Exchange (ETDEWEB)

    Tauxe, J.D.

    1990-12-01

    ShowFlow was created to provide a user-friendly, intuitive environment for researchers and students who use computer modeling software. What traditionally has been a workplace available only to those familiar with command-line based computer systems is now within reach of almost anyone interested in the subject of modeling. In the case of this edition of ShowFlow, the user can easily experiment with simulations using the steady state gaussian plume groundwater pollutant transport model SSGPLUME, though ShowFlow can be rewritten to provide a similar interface for any computer model. Included in this thesis is all the source code for both the ShowFlow application for Microsoft{reg sign} Windows{trademark} and the SSGPLUME model, a User's Guide, and a Developer's Guide for converting ShowFlow to run other model programs. 18 refs., 13 figs.

  12. Analysis and tests of TF magnet insulation samples for the JET upgrade to 4 tesla

    CERN Document Server

    Miele, P; Bettinali, L; Kaye, A; Last, J; Papastergiou, S; Riccardo, V; Visca, E

    2000-01-01

    The JET Toroidal Field (TF) coils were originally designed for operation at 3.4 tesla. In order to upgrade the field to 4 tesla and thus improve the performance of the JET machine, new mechanical tests and analysis were carried out on the insulation of TF coil samples. They are aimed at investigating the mechanical properties and the status of the insulation in order to set allowable stresses and force limits. In particular since the shear stress in the insulation is strongly affected by the shear modulus of elasticity G, it is important to measure this parameter. A method for the measurement of G in glass-resin fibres, the V-notched beam method (Iosipescu method) , was applied. The particular shape of the rectangular Iosipescu V- notched sample and the particular modality of force application produce pure shear stress for a reliable measurement of the G value and of the shear strength of the insulation. The effect of temperature on these mechanical properties was also investigated. Results show higher averag...

  13. Reki-Show Authoring Tools : Risk, Space and History

    Directory of Open Access Journals (Sweden)

    Makoto Hanashima

    2005-12-01

    Full Text Available In social sciences, most events occur in specific time and space. We call such events here "Spatiotemporal Events". It is obvious that events, having always a beginning and an end, appear at a specific place or in particular space. Suppose there exists an conceptual data model regulating some rules to describe those factors, it enables us to store various spatiotemporal events as data and to refer with one another. We, therefore, define a simple spatiotemporal data model, calling "Reki-Show". We also call the information system, consisting of Reki-Show data model, "Reki-Show System", and consider Reki-Show System as the basic information system to deal with the various events in human society. Accordingly, we have recognized that it is indispensable in the future social sciences to have the database and tool for both the temporal and spatial attributes, and have been developing Reki-Show Authoring Tools based on the conceptual framework in Reki-Show System. At present, the fundamental component has been developed already through some steps, and the system is now applied to the empirical research. We would like to make a report of the outline at this stage. This paper explains the basic concept in Reki-Show (Conseptual Data Modeling, followed by the outline of the implemented system.

  14. QLab 3 show control projects for live performances & installations

    CERN Document Server

    Hopgood, Jeromy

    2013-01-01

    Used from Broadway to Britain's West End, QLab software is the tool of choice for many of the world's most prominent sound, projection, and integrated media designers. QLab 3 Show Control: Projects for Live Performances & Installations is a project-based book on QLab software covering sound, video, and show control. With information on both sound and video system basics and the more advanced functions of QLab such as MIDI show control, new OSC capabilities, networking, video effects, and microphone integration, each chapter's specific projects will allow you to learn the software's capabilitie

  15. Volcanic carbon dioxide vents show ecosystem effects of ocean acidification.

    Science.gov (United States)

    Hall-Spencer, Jason M; Rodolfo-Metalpa, Riccardo; Martin, Sophie; Ransome, Emma; Fine, Maoz; Turner, Suzanne M; Rowley, Sonia J; Tedesco, Dario; Buia, Maria-Cristina

    2008-07-01

    The atmospheric partial pressure of carbon dioxide (p(CO(2))) will almost certainly be double that of pre-industrial levels by 2100 and will be considerably higher than at any time during the past few million years. The oceans are a principal sink for anthropogenic CO(2) where it is estimated to have caused a 30% increase in the concentration of H(+) in ocean surface waters since the early 1900s and may lead to a drop in seawater pH of up to 0.5 units by 2100 (refs 2, 3). Our understanding of how increased ocean acidity may affect marine ecosystems is at present very limited as almost all studies have been in vitro, short-term, rapid perturbation experiments on isolated elements of the ecosystem. Here we show the effects of acidification on benthic ecosystems at shallow coastal sites where volcanic CO(2) vents lower the pH of the water column. Along gradients of normal pH (8.1-8.2) to lowered pH (mean 7.8-7.9, minimum 7.4-7.5), typical rocky shore communities with abundant calcareous organisms shifted to communities lacking scleractinian corals with significant reductions in sea urchin and coralline algal abundance. To our knowledge, this is the first ecosystem-scale validation of predictions that these important groups of organisms are susceptible to elevated amounts of p(CO(2)). Sea-grass production was highest in an area at mean pH 7.6 (1,827 (mu)atm p(CO(2))) where coralline algal biomass was significantly reduced and gastropod shells were dissolving due to periods of carbonate sub-saturation. The species populating the vent sites comprise a suite of organisms that are resilient to naturally high concentrations of p(CO(2)) and indicate that ocean acidification may benefit highly invasive non-native algal species. Our results provide the first in situ insights into how shallow water marine communities might change when susceptible organisms are removed owing to ocean acidification.

  16. Do men and women show love differently in marriage?

    Science.gov (United States)

    Schoenfeld, Elizabeth A; Bredow, Carrie A; Huston, Ted L

    2012-11-01

    In Western societies, women are considered more adept than men at expressing love in romantic relationships. Although scholars have argued that this view of love gives short shrift to men's ways of showing love (e.g., Cancian, 1986; Noller, 1996), the widely embraced premise that men and women "love differently" has rarely been examined empirically. Using data collected at four time points over 13 years of marriage, the authors examined whether love is associated with different behaviors for husbands and wives. Multilevel analyses revealed that, counter to theoretical expectations, both genders were equally likely to show love through affection. But whereas wives expressed love by enacting fewer negative or antagonistic behaviors, husbands showed love by initiating sex, sharing leisure activities, and doing household work together with their wives. Overall, the findings indicate that men and women show their love in more nuanced ways than cultural stereotypes suggest.

  17. Chronic Bullying Can Show Up in Report Cards

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_163318.html Chronic Bullying Can Show Up in Report Cards Study found ... 2017 MONDAY, Jan. 30, 2017 (HealthDay News) -- Chronic bullying can take a toll on kids' grades. That's ...

  18. Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder

    Science.gov (United States)

    ... 1999 Spotlight on Research 2014 February 2014 (historical) Protein Replacement Therapy Shows Promise in Treating Rare Skin Disorder Replacing a protein that is crucial to ensuring that the skin’s ...

  19. When Should Zero Be Included on a Scale Showing Magnitude?

    Science.gov (United States)

    Kozak, Marcin

    2011-01-01

    This article addresses an important problem of graphing quantitative data: should one include zero on the scale showing magnitude? Based on a real time series example, the problem is discussed and some recommendations are proposed.

  20. Genital Herpes Vaccine Shows Promise in Animal Trials

    Science.gov (United States)

    ... 163137.html Genital Herpes Vaccine Shows Promise in Animal Trials Two-pronged approach tested on lab monkeys, guinea ... vaccines have not shown very robust protection in animal and human trials. Friedman and his colleagues decided that an effective ...

  1. Web-Based Help for Insomnia Shows Promise

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162290.html Web-Based Help for Insomnia Shows Promise Interactive program ... Now, insomnia might be one of them. A web-based interactive program may help chronically sleepless individuals ...

  2. Parent-Led Autism Therapy Shows Lasting Benefits

    Science.gov (United States)

    ... medlineplus.gov/news/fullstory_161690.html Parent-Led Autism Therapy Shows Lasting Benefits Early intervention reduced symptom ... may have lasting benefits for young children with autism, a new clinical trial suggests. Researchers from the ...

  3. Zika May Persist for Months in Newborns, Study Shows

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_160594.html Zika May Persist for Months in Newborns, Study Shows ... There's more bad news when it comes to Zika's effect on infants: A case study suggests the ...

  4. [Keeping of horses in circus and show businesses].

    Science.gov (United States)

    Pollmann, U

    2002-03-01

    The conditions under which horses are kept and the performance of acts in the circus ring may give rise to animal protection-relevant aspects for circus and show horses. A number of intolerable conditions under which horses are kept and procedures adopted for the work with circus and show horses are described. In addition, attention is drawn to monitoring methods capable of exposing the deplorable shortcomings of these businesses.

  5. Filming the freak show. Non-normative bodies on screen.

    Science.gov (United States)

    Brodesco, Alberto

    2014-01-01

    The article focuses on four films that display the exhibition for profit of non- normative bodies in a context that is variously called freak show, sideshow, monster show, odditorium. Freaks (Tod Browning, 1932), The Ape Woman (La donna scimmia, Marco Ferreri, 1964), Elephant Man (David Lynch, 1980) and Black Venus (Venus noire, Abdellatif Kechiche, 2010) are reflexive movies that tell stories of abnormal bodies and of people who buy a ticket to see them. They inquire the fictional nature of "freakness"--a cultural and historical artefact, a social construction, a frame of mind and a set of practices--and draw attention to the continuity between the world of the freak shows and the scientific and medical milieus. The article finally considers the new visibility of the corporeal freak in contemporary voyeuristic television programs.

  6. Pedagogical Techniques Employed by the Television Show "MythBusters"

    Science.gov (United States)

    Zavrel, Erik

    2016-11-01

    "MythBusters," the long-running though recently discontinued Discovery Channel science entertainment television program, has proven itself to be far more than just a highly rated show. While its focus is on entertainment, the show employs an array of pedagogical techniques to communicate scientific concepts to its audience. These techniques include: achieving active learning, avoiding jargon, employing repetition to ensure comprehension, using captivating demonstrations, cultivating an enthusiastic disposition, and increasing intrinsic motivation to learn. In this content analysis, episodes from the show's 10-year history were examined for these techniques. "MythBusters" represents an untapped source of pedagogical techniques, which science educators may consider availing themselves of in their tireless effort to better reach their students. Physics educators in particular may look to "MythBusters" for inspiration and guidance in how to incorporate these techniques into their own teaching and help their students in the learning process.

  7. Five Kepler target stars that show multiple transiting exoplanet candidates

    CERN Document Server

    Steffen, Jason H; Borucki, William J; Buchhave, Lars A; Caldwell, Douglas A; Cochran, William D; Endl, Michael; Fabrycky, Daniel C; Fressin, François; Ford, Eric B; Fortney, Jonathan J; Haas, Michael J; Holman, Matthew J; Isaacson, Howard; Jenkins, Jon M; Koch, David; Latham, David W; Lissauer, Jack J; Moorhead, Althea V; Morehead, Robert C; Marcy, Geoffrey; MacQueen, Phillip J; Quinn, Samuel N; Ragozzine, Darin; Rowe, Jason F; Sasselov, Dimitar D; Seager, Sara; Torres, Guillermo; Welsh, William F

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compos...

  8. Uni Dufour | Ig Nobel Show with Marc Abrahams | 7 May

    CERN Multimedia

    2013-01-01

    On 7 May, Marc Abrahams, founder of the Ig Nobel Prize, will give an "Ig Nobel show", in English at Uni Dufour. The Ig Nobel Prizes are an American parody of the Nobel Prizes. In early October of each year, they are awarded to ten unusual or trivial achievements in scientific research. The stated aim of the prizes is to "first make people laugh, and then make them think". Marc Abrahams will introduce this funny and dynamic evening with a short presentation before handing over to a selection of recipients. The show is free and open to all. Tuesday 7 May Ig Nobel Show 6:30 p.m. - Room U600 Uni Dufour

  9. Modelli televisivi e apprendimento. Il talk show “Gladiattori”

    Directory of Open Access Journals (Sweden)

    Lorenzo Denicolai

    2015-09-01

    Full Text Available L’articolo presenta il talk show “Gladiattori”, format per web tv ideato e sviluppato dal centro interdipartimentale di ricerca Cinedumedia, Dipartimento di Filosofia e Scienze dell’Educazione, Università degli Studi di Torino. Lo scopo del progetto è sperimentare una metodologia didattica innovativa con il video e i linguaggi multimediali. Partendo dalla teoria del dialogo platonico e da alcuni studi di pragmatica, comunicazione, antropologia della performance e televisione, l’articolo analizza come il talk show (e, in genere, il video possa essere utilizzato nella didattica e nella formazione per acquisire competenze e conoscenza e applicare un nuovo interattivo, collaborativo e collettivo metodo di studio.

  10. CERN cars drive by the Geneva Motor Show

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    One of CERN's new gas-fuelled cars was a special guest at the press days of the Geneva motor show this year. The car enjoyed a prominent position on the Gazmobil stand, right next to the latest Mazeratis and Ferraris. Journalists previewing the motor show could discover CERN's support for green technologies and also find out more about the lab - home to the fastest racetrack on the planet, with protons in the LHC running at 99.9999991% of the speed of light.    

  11. The Biochemistry Show: a new and fun tool for learning

    Directory of Open Access Journals (Sweden)

    A.H Ono

    2006-07-01

    Full Text Available The traditional methods to teach biochemistry in most universities are based on the memorization of chemical structures,  biochemical  pathways  and  reagent  names,  which  is  many  times  dismotivating  for  the  students.  We presently describe an innovative, interactive and alternative method for teaching biochemistry to medical and nutrition undergraduate students, called the Biochemistry Show (BioBio Show.The Biobio show is based on active participation of the students. They are divided in groups and the groups face each other. One group faces another one group at a time, in a game based on true or false questions that involve subjects of applied biochemistry (exercise, obesity, diabetes, cholesterol, free radicals, among others. The questions of the Show are previously elaborated by senior students. The Biobio Show has four phases, the first one is a selection exam, and from the second to the fourth phase, eliminatory confrontations happen. On a confrontation, the first group must select a certain quantity of questions for the opponent to answer.  The group who choses the questions must know how to answer and justify the selected questions. This procedure is repeated on all phases of the show. On the last phase, the questions used are taken from an exam previously performed by the students: either the 9-hour biochemistry exam (Sé et al. A 9-hour biochemistry exam. An iron man competition or a good way of evaluating undergraduate students? SBBq 2005, abstract K-6 or the True-or-False exam (TFE (Sé et al. Are tutor-students capable of writing good biochemistry exams? SBBq 2004, abstract K-18. The winner group receives an extra 0,5 point on the final grade. Over 70% of the students informed on a questionnaire that the Biobio Show is a valuable tool for learning biochemistry.    That is a new way to enrich the discussion of biochemistry in the classroom without the students getting bored. Moreover, learning

  12. Strobes: Pyrotechnic Compositions That Show a Curious Oscillatory Combustion

    NARCIS (Netherlands)

    Corbel, J.M.L.; van Lingen, J.N.J.; Zevenbergen, J.F.; Gijzeman, O.L.J.; Meijerink, A.

    2013-01-01

    Strobes are pyrotechnic compositions which show an oscillatory combustion; a dark phase and a flash phase alternate periodically. The strobe effect has applications in various fields, most notably in the fireworks industry and in the military area. All strobe compositions mentioned in the literature

  13. Mice lacking neuropeptide Y show increased sensitivity to cocaine

    DEFF Research Database (Denmark)

    Sørensen, Gunnar; Woldbye, David Paul Drucker

    2012-01-01

    There is increasing data implicating neuropeptide Y (NPY) in the neurobiology of addiction. This study explored the possible role of NPY in cocaine-induced behavior using NPY knockout mice. The transgenic mice showed a hypersensitive response to cocaine in three animal models of cocaine addiction...

  14. Design Your Organization's Own Slide-Tape Show

    Science.gov (United States)

    Tilden, Scott W.

    1975-01-01

    Slide-tape shows offer a relatively inexpensive, easy-to-assemble means of informing a wide variety of groups interested in education. This article outlines a seven-step procedure to produce a coherent, professional-looking slide-tape presentation. (DS)

  15. Authenticity and TV Shows: A Multidimensional Analysis Perspective

    Science.gov (United States)

    Al-Surmi, Mansoor

    2012-01-01

    Television shows, especially soap operas and sitcoms, are usually considered by English as a second language practitioners as a source of authentic spoken conversational materials presumably because they reflect the linguistic features of natural conversation. However, practitioners are faced with the dilemma of how to assess whether such…

  16. French City Calais Shows Great Appetite for Chinese Stone Materials

    Institute of Scientific and Technical Information of China (English)

    Xu Hao

    2005-01-01

    @@ A French government delegation headed by the President of the Municipal Planning & Design Bureau of Calais City and Mr. Han Guogang, President of France China International Development Institution investigated Chinese stone materials market during April 28 to April 29, they showed great interest in some stone materials in good quality such as "China Black".

  17. Using "The Daily Show" to Promote Media Literacy

    Science.gov (United States)

    Garrett, H. James; Schmeichel, Mardi

    2012-01-01

    Social studies teachers are tasked with aiding their students' abilities to engage in public debate and make politically sound decisions. One way the authors have found to help facilitate this is to draw connections between content knowledge and current political conversations through the use of clips from "The Daily Show with Jon Stewart." While…

  18. Five kepler target stars that show multiple transiting exoplanet candidates

    DEFF Research Database (Denmark)

    Steffen..[], Jason H.; Batalha, N. M.; Broucki, W J.;

    2010-01-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets...

  19. Auto Show Exhibition:An Interests-Powered Lever

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Many years in the segment,Li Cheng(not his real name )still can not tell for sure whether the auto development leads auto show exhibitions or the reverse."Both of them have been doing the leadership job,"he said.His passion

  20. Autopsied case of tuberculous meningitis showing interesting CT findings

    Energy Technology Data Exchange (ETDEWEB)

    Abiko, Takashi; Higuchi, Hiroshi; Imada, Ryuichi; Nagai, Kenichi (Iwate Prefectural Central Hospital (Japan))

    1983-11-01

    A 61-year-old female patient died of a neurological disorder of unknown origin one month after the first visit and was found to have had tuberculous meningitis at autopsy. CT revealed a low density area showing an enlargement of the cerebral ventricle but did not reveal contrast enhancement in the basal cistern peculiar to tuberculous meningitis.

  1. Data from the Television Game Show "Friend or Foe?"

    Science.gov (United States)

    Kalist, David E.

    2004-01-01

    The data discussed in this paper are from the television game show "Friend or Foe", and can be used to examine whether age, gender, race, and the amount of prize money affect contestants' strategies. The data are suitable for a variety of statistical analyses, such as descriptive statistics, testing for differences in means or proportions, and…

  2. The neonicotinoid imidachloprid shows high chronic toxicity to mayfly nymphs

    NARCIS (Netherlands)

    Roessink, I.; Merga, L.B.; Zweers, A.J.; Brink, van den P.J.

    2013-01-01

    The present study evaluated the acute and chronic toxicity of imidacloprid to a range of freshwater arthropods. Mayfly and caddisfly species were most sensitive to short-term imidacloprid exposures (10 tests), whereas the mayflies showed by far the most sensitive response to long-term exposure of al

  3. Strobes: Pyrotechnic compositions that show a curious oscillatory combustion

    NARCIS (Netherlands)

    Corbel, J.M.L.; Lingen, J.N.J. van; Zevenbergen, J.F.; Gijzeman, O.L.J.; Meijerink, A.

    2013-01-01

    Strobes are pyrotechnic compositions which show an oscillatory combustion; a dark phase and a flash phase alternate periodically. The strobe effect has applications in various fields, most notably in the fireworks industry and in the military area. All strobe compositions mentioned in the literature

  4. "Country Life"? Rurality, Folk Music and "Show of Hands"

    Science.gov (United States)

    Yarwood, Richard; Charlton, Clive

    2009-01-01

    This paper examines the contribution of folk music to understanding the dynamic, fluid and multi-experiential nature of the countryside. Drawing from literature on the geographies of music, it examines the work of "Show of Hands", a contemporary folk band from Devon in England. Three areas are studied. First, the paper examines the…

  5. Giant primary angiosarcoma of the small intestine showing severe sepsis.

    Science.gov (United States)

    Takahashi, Mizuna; Ohara, Masanori; Kimura, Noriko; Domen, Hiromitsu; Yamabuki, Takumi; Komuro, Kazuteru; Tsuchikawa, Takahiro; Hirano, Satoshi; Iwashiro, Nozomu

    2014-11-21

    Primary malignant tumors of the small intestine are rare, comprising less than 2% of all gastrointestinal tumors. An 85-year-old woman was admitted with fever of 40 °C and marked abdominal distension. Her medical history was unremarkable, but blood examination showed elevated inflammatory markers. Abdominal computed tomography showed a giant tumor with central necrosis, extending from the epigastrium to the pelvic cavity. Giant gastrointestinal stromal tumor of the small intestine communicating with the gastrointestinal tract or with superimposed infection was suspected. Because no improvement occurred in response to antibiotics, surgery was performed. Laparotomy revealed giant hemorrhagic tumor adherent to the small intestine and occupying the peritoneal cavity. The giant tumor was a solid tumor weighing 3490 g, measuring 24 cm × 17.5 cm × 18 cm and showing marked necrosis. Histologically, the tumor comprised spindle-shaped cells with anaplastic large nuclei. Immunohistochemical studies showed tumor cells positive for vimentin, CD31, and factor VIII-related antigen, but negative for c-kit and CD34. Angiosarcoma was diagnosed. Although no postoperative complications occurred, the patient experienced enlargement of multiple metastatic tumors in the abdominal cavity and died 42 d postoperatively. The prognosis of small intestinal angiosarcoma is very poor, even after volume-reducing palliative surgery.

  6. Teaching Job Interviewing Skills with the Help of Television Shows

    Science.gov (United States)

    Bloch, Janel

    2011-01-01

    Because of its potential for humor and drama, job interviewing is frequently portrayed on television. This article discusses how scenes from popular television series such as "Everybody Loves Raymond," "Friends," and "The Mary Tyler Moore Show" can be used to teach effective job interview skills in business communication courses. Television…

  7. New Inspiring Planetarium Show Introduces ALMA to the Public

    Science.gov (United States)

    2009-03-01

    As part of a wide range of education and public outreach activities for the International Year of Astronomy 2009 (IYA2009), ESO, together with the Association of French Language Planetariums (APLF), has produced a 30-minute planetarium show, In Search of our Cosmic Origins. It is centred on the global ground-based astronomical Atacama Large Millimeter/submillimeter Array (ALMA) project and represents a unique chance for planetariums to be associated with the IYA2009. ESO PR Photo 09a/09 Logo of the ALMA Planetarium Show ESO PR Photo 09b/09 Galileo's first observations with a telescope ESO PR Photo 09c/09 The ALMA Observatory ESO PR Photo 09d/09 The Milky Way band ESO PR Video 09a/09 Trailer in English ALMA is the leading telescope for observing the cool Universe -- the relic radiation of the Big Bang, and the molecular gas and dust that constitute the building blocks of stars, planetary systems, galaxies and life itself. It is currently being built in the extremely arid environment of the Chajnantor plateau, at 5000 metres altitude in the Chilean Andes, and will start scientific observations around 2011. ALMA, the largest current astronomical project, is a revolutionary telescope, comprising a state-of-the-art array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. In Search of our Cosmic Origins highlights the unprecedented window on the Universe that this facility will open for astronomers. "The show gives viewers a fascinating tour of the highest observatory on Earth, and takes them from there out into our Milky Way, and beyond," says Douglas Pierce-Price, the ALMA Public Information Officer at ESO. Edited by world fulldome experts Mirage3D, the emphasis of the new planetarium show is on the incomparable scientific adventure of the ALMA project. A young female astronomer guides the audience through a story that includes unique animations and footage, leading the viewer from the first observations by Galileo

  8. HUBBLE VISION: A Planetarium Show About Hubble Space Telescope

    Science.gov (United States)

    Petersen, Carolyn Collins

    1995-05-01

    In 1991, a planetarium show called "Hubble: Report From Orbit" outlining the current achievements of the Hubble Space Telescope was produced by the independent planetarium production company Loch Ness Productions, for distribution to facilities around the world. The program was subsequently converted to video. In 1994, that program was updated and re-produced under the name "Hubble Vision" and offered to the planetarium community. It is periodically updated and remains a sought-after and valuable resource within the community. This paper describes the production of the program, and the role of the astronomical community in the show's production (and subsequent updates). The paper is accompanied by a video presentation of Hubble Vision.

  9. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

    Science.gov (United States)

    Sanchez-Mut, J V; Heyn, H; Vidal, E; Moran, S; Sayols, S; Delgado-Morales, R; Schultz, M D; Ansoleaga, B; Garcia-Esparcia, P; Pons-Espinal, M; de Lagran, M M; Dopazo, J; Rabano, A; Avila, J; Dierssen, M; Lott, I; Ferrer, I; Ecker, J R; Esteller, M

    2016-01-01

    Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies. PMID:26784972

  10. Preschoolers show less trust in physically disabled or obese informants

    Directory of Open Access Journals (Sweden)

    Sara eJaffer

    2015-01-01

    Full Text Available This research examined whether preschool-aged children show less trust in physically disabled or obese informants. In Study 1, when learning about novel physical activities and facts, 4- and 5-year-olds preferred to endorse the testimony of a physically abled, non-obese informant rather than a physically disabled or obese one. In Study 2, after seeing that the physically disabled or obese informant was previously reliable whereas the physically abled, non-obese one was unreliable, 4- and 5-year-olds did not show a significant preference for either informant. We conclude that in line with the literature on children’s negative stereotypes of physically disabled or obese others, preschoolers are biased against these individuals as potential sources of new knowledge. This bias is robust in that past reliability might undermine its effect on children, but cannot reverse it.

  11. Neuro-Behcet's disease showing severe atrophy of the cerebrum.

    Science.gov (United States)

    Miyakawa, T; Murayama, E; Deshimaru, M; Shikai, I; Kozuma, S

    1976-03-15

    A 38-year-old female died 6 years after the onset of what was, clinically and histopathologically, consistent with neuro-Behcet's disease. Pathologically the cerebrum showed severe atrophy. The main changes were observed in the grey and white matter, the diencephalon and the basal ganglia by light microscopy. All these changes originated in softenings around blood vessels, especially small vessels or capillaries. These foci fused together to form large regions of softening. Glial or mesenchymal reactions were minimal. In the white matter there was slight perivascular-infiltration, mainly consisting of lymphocytes. In view of these findings, it is suggested that these changes were caused by an allergic vasculitis. The present case of Neuro-Behcet's disease is the first one showing general atrophy of the cerebrum. It is very important in relation to demyelinating encephalitis.

  12. El reality show a la hora de la merienda

    Directory of Open Access Journals (Sweden)

    Lic. Rosa María Ganga Ganga

    2000-01-01

    Full Text Available Los programas de testimonio, inscritos dentro del género televisivo del Reality Show, son una variante del más amplio subgénero del Talk Show y tienen ya una cierta tradición en nuestro país. El presente trabajo se centrará en este tipo de programas de testimonio que basan su estrategia discursiva en la presentación y representación del relato autobiográfico del hombre o la mujer anónimos, integrándose de esta forma en las corrientes más recientes de la sociología y la historiografía, y persigue esclarecer algunas de sus características y funciones, especialmente su función socializadora, a través del mecanismo biográfico y del concepto de habitus tomado de Pierre Bourdieu.

  13. Cambrian stalked echinoderms show unexpected plasticity of arm construction.

    Science.gov (United States)

    Zamora, S; Smith, A B

    2012-01-22

    Feeding arms carrying coelomic extensions of the theca are thought to be unique to crinoids among stemmed echinoderms. However, a new two-armed echinoderm from the earliest Middle Cambrian of Spain displays a highly unexpected morphology. X-ray microtomographic analysis of its arms shows they are polyplated in their proximal part with a dorsal series of uniserial elements enclosing a large coelomic lumen. Distally, the arm transforms into the more standard biserial structure of a blastozoan brachiole. Phylogenetic analysis demonstrates that this taxon lies basal to rhombiferans as sister-group to pleurocystitid and glyptocystitid blastozoans, drawing those clades deep into the Cambrian. We demonstrate that Cambrian echinoderms show surprising variability in the way their appendages are constructed, and that the appendages of at least some blastozoans arose as direct outgrowths of the body in much the same way as the arms of crinoids.

  14. Revisiting Dystopia: the Reality Show Biopolitics of "The Hunger Games"

    Directory of Open Access Journals (Sweden)

    Fani Cettl

    2015-10-01

    Full Text Available This paper explores the dystopian imaginaries of the recent popular novel trilogy The Hunger Games by Suzanne Collins and its film adaptations. Having put the narrative into a genealogy of dystopian fiction concerned with the historical nation-state totalitarianisms, I ask what is specifically contemporary about The Hunger Games. I explore this by focusing on the functioning of the reality show format in the narrative, which I link to G. Agamben’s understanding of the spectacle, as part of his wider biopolitical theories. I apply an Agambenian biopolitical reading to the narrative, seeing it as a production of bare life through the camp of the reality show arena. I suggest that The Hunger Games offer a critique of contemporary liberal democracies by calling attention to their production of underclassed and expendable life, which is imagined as an eruption of the nation-state right to kill, similarly as in Agamben’s theories.

  15. Earth, the "star" of an original Planetarium show

    Science.gov (United States)

    Azoulay, G.; Acker, A.

    2003-04-01

    Thanks the spatial observations, the astronomers are abble to complete their representations of the universe, and scientists can observe the Earth as a planet like Venus or Mars. A collaboration between the CNES (Centre National d'Etudes Spatiales) and the APLF (Association des Planétariums de Langue Française or French speaking Planetariums Association) allowed the presentation into the Planetariums of (1) images and data related to spatial news, and (2) a specific show constructed by the CNES and the APLF, and devoted to Earth as an astronomical object. This original show is presented in 5 langages by 36 Planétariums since 2002, April, and we report on the reactions of both the visitors and the animators.

  16. El reality show a la hora de la merienda

    OpenAIRE

    Lic. Rosa María Ganga Ganga

    2000-01-01

    Los programas de testimonio, inscritos dentro del género televisivo del Reality Show, son una variante del más amplio subgénero del Talk Show y tienen ya una cierta tradición en nuestro país. El presente trabajo se centrará en este tipo de programas de testimonio que basan su estrategia discursiva en la presentación y representación del relato autobiográfico del hombre o la mujer anónimos, integrándose de esta forma en las corrientes más recientes de la sociología y la historiografía, y persi...

  17. All the new Styles Showing on Auto China 2006

    Institute of Scientific and Technical Information of China (English)

    Gao; Canhua; Ren; Lin

    2006-01-01

      On the occasion of Auto China 2006 from November 18 to 27, 2006, as the representative of China independent brands, Land Wind will take the theme of "Roads in the World, I Drive Anywhere I Like",leads all the new styles of automobiles to show on Auto China 2006, including X6, X9, Land Wind Fashion, and the economical coupe Land Wind CV7,which will be put into market next year..……

  18. All the new Styles Showing on Auto China 2006

    Institute of Scientific and Technical Information of China (English)

    Gao Canhua; Ren Lin

    2006-01-01

    @@ On the occasion of Auto China 2006 from November 18 to 27, 2006, as the representative of China independent brands, Land Wind will take the theme of "Roads in the World, I Drive Anywhere I Like",leads all the new styles of automobiles to show on Auto China 2006, including X6, X9, Land Wind Fashion, and the economical coupe Land Wind CV7,which will be put into market next year..

  19. Sidelights on Peking Opera and Kabuki Joint Show

    Institute of Scientific and Technical Information of China (English)

    Zhang; Yaqin

    2015-01-01

    On April 2 and April 3,Chinese Peking Opera and Japanese Kabuki were performed on the same stage to sellout audiences at the Beijing Mei Lanfang Grand Theater.Two classics of Peking Opera,Farewell My Concubine and The Great Enthronement,were performed respectively in the first half of the show,followed in the second half by a famous Kabuki play,The Mirror Lion—A Spring Entertainment.

  20. Size and depth of vocabulary knowledge: what the research shows

    OpenAIRE

    Schmitt, Norbert

    2014-01-01

    When discussing vocabulary, a distinction is often made between size of vocabulary (number of known words) and depth of knowledge (how well those words are known). However, the relationship between the two constructs is still unclear. Some scholars argue that there is little real difference between the two, while regression analyses show that depth typically adds unique explanatory power compared to size alone. Ultimately, the relationship between size and depth of vocabulary knowledge depend...

  1. A Solved Model to Show Insufficiency of Quantitative Adiabatic Condition

    Institute of Scientific and Technical Information of China (English)

    LIU Long-Jiang; LIU Yu-Zhen; TONG Dian-Min

    2009-01-01

    The adiabatic theorem is a useful tool in processing quantum systems slowly evolving,but its practical application depends on the quantitative condition expressed by Hamiltonian's eigenvalues and eigenstates,which is usually taken as a sufficient condition.Recently,the sumciency of the condition was questioned,and several counterex amples have been reported.Here we present a new solved model to show the insufficiency of the traditional quantitative adiabatic condition.

  2. Five Kepler target stars that show multiple transiting exoplanet candidates

    Energy Technology Data Exchange (ETDEWEB)

    Steffen, Jason H.; /Fermilab; Batalha, Natalie M.; /San Jose State U.; Borucki, William J.; /NASA, Ames; Buchhave, Lars A.; /Harvard-Smithsonian Ctr. Astrophys. /Bohr Inst.; Caldwell, Douglas A.; /NASA, Ames /SETI Inst., Mtn. View; Cochran, William D.; /Texas U.; Endl, Michael; /Texas U.; Fabrycky, Daniel C.; /Harvard-Smithsonian Ctr. Astrophys.; Fressin, Francois; /Harvard-Smithsonian Ctr. Astrophys.; Ford, Eric B.; /Florida U.; Fortney, Jonathan J.; /UC, Santa Cruz, Phys. Dept. /NASA, Ames

    2010-06-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities - two near 2:1 and one just outside 5:2. We discuss the implications that multitransiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories; as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTV) due to gravitational interactions - though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  3. Five Kepler Target Stars That Show Multiple Transiting Exoplanet Candidates

    Science.gov (United States)

    Steffen, Jason H.; Batalha, Natalie M.; Borucki, William J.; Buchhave, Lars A.; Caldwell, Douglas A.; Cochran, William D.; Endl, Michael; Fabrycky, Daniel C.; Fressin, François; Ford, Eric B.; Fortney, Jonathan J.; Haas, Michael J.; Holman, Matthew J.; Howell, Steve B.; Isaacson, Howard; Jenkins, Jon M.; Koch, David; Latham, David W.; Lissauer, Jack J.; Moorhead, Althea V.; Morehead, Robert C.; Marcy, Geoffrey; MacQueen, Phillip J.; Quinn, Samuel N.; Ragozzine, Darin; Rowe, Jason F.; Sasselov, Dimitar D.; Seager, Sara; Torres, Guillermo; Welsh, William F.

    2010-12-01

    We present and discuss five candidate exoplanetary systems identified with the Kepler spacecraft. These five systems show transits from multiple exoplanet candidates. Should these objects prove to be planetary in nature, then these five systems open new opportunities for the field of exoplanets and provide new insights into the formation and dynamical evolution of planetary systems. We discuss the methods used to identify multiple transiting objects from the Kepler photometry as well as the false-positive rejection methods that have been applied to these data. One system shows transits from three distinct objects while the remaining four systems show transits from two objects. Three systems have planet candidates that are near mean motion commensurabilities—two near 2:1 and one just outside 5:2. We discuss the implications that multi-transiting systems have on the distribution of orbital inclinations in planetary systems, and hence their dynamical histories, as well as their likely masses and chemical compositions. A Monte Carlo study indicates that, with additional data, most of these systems should exhibit detectable transit timing variations (TTVs) due to gravitational interactions, though none are apparent in these data. We also discuss new challenges that arise in TTV analyses due to the presence of more than two planets in a system.

  4. Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction

    Science.gov (United States)

    Elmonem, Mohamed A.; Khalil, Ramzi; Khodaparast, Ladan; Khodaparast, Laleh; Arcolino, Fanny O.; Morgan, Joseph; Pastore, Anna; Tylzanowski, Przemko; Ny, Annelii; Lowe, Martin; de Witte, Peter A.; Baelde, Hans J.; van den Heuvel, Lambertus P.; Levtchenko, Elena

    2017-01-01

    The human ubiquitous protein cystinosin is responsible for transporting the disulphide amino acid cystine from the lysosomal compartment into the cytosol. In humans, Pathogenic mutations of CTNS lead to defective cystinosin function, intralysosomal cystine accumulation and the development of cystinosis. Kidneys are initially affected with generalized proximal tubular dysfunction (renal Fanconi syndrome), then the disease rapidly affects glomeruli and progresses towards end stage renal failure and multiple organ dysfunction. Animal models of cystinosis are limited, with only a Ctns knockout mouse reported, showing cystine accumulation and late signs of tubular dysfunction but lacking the glomerular phenotype. We established and characterized a mutant zebrafish model with a homozygous nonsense mutation (c.706 C > T; p.Q236X) in exon 8 of ctns. Cystinotic mutant larvae showed cystine accumulation, delayed development, and signs of pronephric glomerular and tubular dysfunction mimicking the early phenotype of human cystinotic patients. Furthermore, cystinotic larvae showed a significantly increased rate of apoptosis that could be ameliorated with cysteamine, the human cystine depleting therapy. Our data demonstrate that, ctns gene is essential for zebrafish pronephric podocyte and proximal tubular function and that the ctns-mutant can be used for studying the disease pathogenic mechanisms and for testing novel therapies for cystinosis. PMID:28198397

  5. A duplex kidney with dromedary hump showing altered hilar anatomy

    Directory of Open Access Journals (Sweden)

    Tallapaneni S

    2011-02-01

    Full Text Available A comprehensive knowledge of the wide range of variations of renal vasculature and renal pelvis is mandatory to the anatomists for a better understanding of the embryology. It remains as the key issue in determining the technical feasibility of various endourologic procedures and innumerable intervention techniques besides kidney retrievals for transplantation. In the present case the duplex kidney showed lobulations on the anterior surface just adjacent to the hilar region. The midlateral portion of the convex lateral border of the kidney showed a small focal bulge –dromedary hump. At the hilum reversed anterio-posterior disposition of renal vasculature with anteriorly placed renal artery which bifurcated into two upper and lower anterior segmental branches. The renal vein formed by large tributaries arising from the hilum running towards the inferior vena cava. The renal pelvis was most posteriorly placed which showed a double pelvis. The upper pelvis was seen arising behind the renal vein and the lower pelvis arising inferomedial to the lower anterior segmental artery.Both the pelvises were seen uniting medial to the lower part of hilum and continued as a single ureter which opened into the bladder. The thorough knowledge of these anatomical variations is necessary to avoid iatrogenic injuries and enable the surgeon and radiologists approach unusual situations with confidence rather than surprise.

  6. An Undergraduate Endeavor: Assembling a Live Planetarium Show About Mars

    Science.gov (United States)

    McGraw, Allison M.

    2016-10-01

    Viewing the mysterious red planet Mars goes back thousands of years with just the human eye but in more recent years the growth of telescopes, satellites and lander missions unveil unrivaled detail of the Martian surface that tells a story worth listening to. This planetarium show will go through the observations starting with the ancients to current understandings of the Martian surface, atmosphere and inner-workings through past and current Mars missions. Visual animations of its planetary motions, display of high resolution images from the Hi-RISE (High Resolution Imaging Science Experiment) and CTX (Context Camera) data imagery aboard the MRO (Mars Reconnaissance Orbiter) as well as other datasets will be used to display the terrain detail and imagery of the planet Mars with a digital projection system. Local planetary scientists and Mars specialists from the Lunar and Planetary Lab at the University of Arizona (Tucson, AZ) will be interviewed and used in the show to highlight current technology and understandings of the red planet. This is an undergraduate project that is looking for collaborations and insight in order gain structure in script writing that will teach about this planetary body to all ages in the format of a live planetarium show.

  7. "PH Value" Design Show Unveils the Shanghai Dream%"PH Value" Design Show Unveils the Shanghai Dream

    Institute of Scientific and Technical Information of China (English)

    Wanzy Wang

    2012-01-01

    "PH Value" Design Show, organized by China National Textile and Apparel Council (CNTAC), undertaken by the Sub- Council of Textile Industry, CCPIT (CCPIT-TEX), China Knitting industry Association, and China National Garment Association (CNGA), will be held from October 22rid to 23rd in Shanghai, unveiling the charming mysteries of "Shanghai Dream".

  8. Remembering Operación Triunfo: a Latin Music Reality Show in the Era of Talent Shows

    NARCIS (Netherlands)

    Savini, Paola

    2016-01-01

    abstractThe music format Operación Triunfo (2001–2011), which aired on RTVE for the first time in 2001, started as a television (TV) and musical success in Spain and today is one of the most famous shows around the world as well as an incredible socio-economic phenomenon in Spanish TV. This paper de

  9. New Results from RENO

    CERN Document Server

    ,

    2013-01-01

    RENO (Reactor Experiment for Neutrino Oscillation) is an experiment dedicated to measure the smallest neutrino mixing angle {\\theta}_13 using reactor neutrinos in Korea. Our first result measured in 2012 using about 220 live days of data showed non-zero {\\theta}_13 value with 4.9 {\\sigma} significance. In March 2013 we updated our first result with improvements in both statistical and systematic errors using 403 live days of data. The measured value using rate-only analysis is sin^2(2{\\theta}_13) = 0.100 +/- 0.010 (stat) +/- 0.015 (sys.) corresponding to 6.3 {\\sigma} significance. RENO has been taking data almost continuously since August 2011 and we have reached more than 800 live days of data that is currently being analyzed.

  10. Early results from ISO

    Science.gov (United States)

    1996-01-01

    First findings by Europe's new space telescope ISO (Infrared Space Observatory) will be announced at a press conference to be held at ESA's satellite tracking station in Villafranca, Apartado 50727 - 28080-Madrid, on Wednesday 14 February 1996 Astronomers responsible for ISO's instruments will show results ranging from materials in the planet Saturn, through the birth and death of stars, to the behaviour of colliding galaxies. All instruments are working well and even their preliminary results confirm that ISO is a unique observatory making an unprecedented exploration of the universe by infrared rays. Parallel press conferences will be held at ESA Headquarters in Paris, ESTEC Noordwijk (the Netherlands) and ESOC Darmstadt (Germany) where a live television link will be established with Villafranca and from where the media can participate in the discussion.

  11. Electricity show and related educational programming. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-19

    The on-site version of Balance of Power reached a total audience of 21,331 between November 10, 1994 and January 31, 1996; in addition, the Physics on Wheels van offered exhibits and programs to an additional 30,000 students in the 1995-1996 school year. The program provided a groundbreaking new approach to informal science education, combining a dynamic demonstration with an intensely interactive game show. Between the on-site programming and the Physics on Wheels van programs, 51,331 students were impacted by the activities, exhibits and energy-conservation message of Balance of Power.

  12. Patients with polymyositis show changes in muscle protein charges

    DEFF Research Database (Denmark)

    Bartels, E M; Jacobsen, Søren; Rasmussen, L

    1989-01-01

    Polymyositis (PM) appears with indolent proximal muscle weakness and is an inflammatory disease with breakdown of muscle cells. In our study the protein charge concentrations of the contractile proteins in the A and I bands were determined, applying a microelectrode technique. Patients with PM show...... a lower protein charge concentration than healthy control subjects which may be caused by the breakdown and removal of the proteins in the contractile filaments. A tool to judge the state of the disease as well as an aid in diagnosis may have been found in this method....

  13. E-health technologies show promise in developing countries.

    Science.gov (United States)

    Blaya, Joaquin A; Fraser, Hamish S F; Holt, Brian

    2010-02-01

    Is there any evidence that e-health-using information technology to manage patient care-can have a positive impact in developing countries? Our systematic review of evaluations of e-health implementations in developing countries found that systems that improve communication between institutions, assist in ordering and managing medications, and help monitor and detect patients who might abandon care show promise. Evaluations of personal digital assistants and mobile devices convincingly demonstrate that such devices can be very effective in improving data collection time and quality. Donors and funders should require and sponsor outside evaluations to ensure that future e-health investments are well-targeted.

  14. A Technique for Showing Causal Arguments in Accident Reports

    Science.gov (United States)

    Holloway, C. M.; Johnson, C. W.

    2005-01-01

    In the prototypical accident report, specific findings, particularly those related to causes and contributing factors, are usually written out explicitly and clearly. Also, the evidence upon which these findings are based is typically explained in detail. Often lacking, however, is any explicit discussion, description, or depiction of the arguments that connect the findings and the evidence. That is, the reports do not make clear why the investigators believe that the specific evidence they found necessarily leads to the particular findings they enumerated. This paper shows how graphical techniques can be used to depict relevant arguments supporting alternate positions on the causes of a complex road-traffic accident.

  15. Inconsistent handers show higher psychopathy than consistent handers.

    Science.gov (United States)

    Shobe, Elizabeth; Desimone, Kailey

    2016-01-01

    Three hundred and forty-two university students completed the Short Dark Triad (SD3) and the Edinburgh Handedness Inventory (EHI). Inconsistent handers showed higher psychopathy scores than consistent handers, and no handedness differences were observed for narcissism or Machiavellianism. Participants were further subdivided by quartile into low, moderately low, moderately high, and high psychopathy groups (non-clinical). Absolute EHI scores were equally distributed among low and moderate groups, but were significantly lower for the high psychopathy group. These findings suggest that inconsistent handedness is only associated with the upper quartile of psychopathy scores. Also, males showed significantly higher psychopathy scores than females, and the ratio of male to female inconsistent handers decreased as psychopathy score increased. No gender × handedness interaction indicated that both female and male inconsistent handers have higher psychopathy scores than consistent handers. Although significant, the effects were small and 99.6% of participants were not in the range of a potential clinical diagnosis. The reader, therefore, is strongly cautioned against equating inconsistent handedness with psychopathy.

  16. Mixtures of thermostable enzymes show high performance in biomass saccharification.

    Science.gov (United States)

    Kallioinen, Anne; Puranen, Terhi; Siika-aho, Matti

    2014-07-01

    Optimal enzyme mixtures of six Trichoderma reesei enzymes and five thermostable enzyme components were developed for the hydrolysis of hydrothermally pretreated wheat straw, alkaline oxidised sugar cane bagasse and steam-exploded bagasse by statistically designed experiments. Preliminary studies to narrow down the optimization parameters showed that a cellobiohydrolase/endoglucanase (CBH/EG) ratio of 4:1 or higher of thermostable enzymes gave the maximal CBH-EG synergy in the hydrolysis of hydrothermally pretreated wheat straw. The composition of optimal enzyme mixtures depended clearly on the substrate and on the enzyme system studied. The optimal enzyme mixture of thermostable enzymes was dominated by Cel7A and required a relatively high amount of xylanase, whereas with T. reesei enzymes, the high proportion of Cel7B appeared to provide the required xylanase activity. The main effect of the pretreatment method was that the required proportion of xylanase was higher and the proportion of Cel7A lower in the optimized mixture for hydrolysis of alkaline oxidised bagasse than steam-exploded bagasse. In prolonged hydrolyses, less Cel7A was generally required in the optimal mixture. Five-component mixtures of thermostable enzymes showed comparable hydrolysis yields to those of commercial enzyme mixtures.

  17. Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity

    Science.gov (United States)

    Nguyen, Quyen L.; Corey, Catherine; White, Pamela; Watson, Annie; Gladwin, Mark T.; Simon, Marc A.

    2017-01-01

    Accumulating evidence suggests that altered cellular metabolism is systemic in pulmonary hypertension (PH) and central to disease pathogenesis. However, bioenergetic changes in PH patients and their association with disease severity remain unclear. Here, we hypothesize that alteration in bioenergetic function is present in platelets from PH patients and correlates with clinical parameters of PH. Platelets isolated from controls and PH patients (n = 28) were subjected to extracellular flux analysis to determine oxygen consumption and glycolytic rates. Platelets from PH patients showed greater glycolytic rates than controls. Surprisingly, this was accompanied by significant increases in the maximal capacity for oxygen consumption, leading to enhanced respiratory reserve capacity in PH platelets. This increased platelet reserve capacity correlated with mean pulmonary artery pressure, pulmonary vascular resistance, and right ventricular stroke work index in PH patients and was abolished by the inhibition of fatty acid oxidation (FAO). Consistent with a shift to FAO, PH platelets showed augmented enzymatic activity of carnitine palmitoyltransferase-1 and electron transport chain complex II. These data extend the observation of a metabolic alteration in PH from the pulmonary vascular axis to the hematologic compartment and suggest that measurement of platelet bioenergetics is potentially useful in assessment of disease progression and severity. PMID:28289721

  18. Human hyolaryngeal movements show adaptive motor learning during swallowing.

    Science.gov (United States)

    Humbert, Ianessa A; Christopherson, Heather; Lokhande, Akshay; German, Rebecca; Gonzalez-Fernandez, Marlis; Celnik, Pablo

    2013-06-01

    The hyoid bone and larynx elevate to protect the airway during swallowing. However, it is unknown whether hyolaryngeal movements during swallowing can adjust and adapt to predict the presence of a persistent perturbation in a feed-forward manner (adaptive motor learning). We investigated adaptive motor learning in nine healthy adults. Electrical stimulation was administered to the anterior neck to reduce hyolaryngeal elevation, requiring more strength to swallow during the perturbation period of this study. We assessed peak hyoid bone and laryngeal movements using videofluoroscopy across thirty-five 5-ml water swallows. Evidence of adaptive motor learning of hyolaryngeal movements was found when (1) participants showed systematic gradual increases in elevation against the force of electrical stimulation and (2) hyolaryngeal elevation overshot the baseline (preperturbation) range of motion, showing behavioral aftereffects, when the perturbation was unexpectedly removed. Hyolaryngeal kinematics demonstrates adaptive, error-reducing movements in the presence of changing and unexpected demands. This is significant because individuals with dysphagia often aspirate due to disordered hyolaryngeal movements. Thus, if rapid motor learning is accessible during swallowing in healthy adults, patients may be taught to predict the presence of perturbations and reduce errors in swallowing before they occur.

  19. CERN's gamble shows perils, rewards of playing the odds

    CERN Multimedia

    Seife, C

    2000-01-01

    Data from LEP has a three to four sigma certainty that the Higgs Boson has been seen. To declare a discovery though, normally five sigma is required. This article examines other occasions where even with this degree of certainty, the results finally turned out to be spurious (3 pages).

  20. Satellite signal shows storage-unloading subsidence in North China

    Science.gov (United States)

    Moiwo, J. P.; Tao, F.

    2015-06-01

    Worsening water storage depletion (WSD) contributes to environmental degradation, land subsidence and earthquake and could disrupt food production/security and social stability. There is need for efficient water use strategies in North China, a pivotal agrarian, industrial and political base in China with a widespread WSD. This study integrates satellite, model and field data products to investigate WSD and land subsidence in North China. In the first step, GRACE (Gravity Recovery and Climate Experiment) mass rates are used to show WSD in the region. Next, GRACE total water storage (TWS) is corrected for soil water storage (SWS) to derive groundwater storage (GWS) using GLDAS (Global Land Data Assimilation System) data products. The derived GWS is compared with GWS obtained from field-measured groundwater level to show land subsidence in the study area. Then GPS (Global Positioning System) data of relative land surface change (LSC) are used to confirm the subsidence due to WSD. A total of ~ 96 near-consecutive months (January 2002 through December 2009) of datasets are used in the study. Based on GRACE mass rates, TWS depletion is 23.76 ± 1.74 mm yr-1 or 13.73 ± 1.01 km3 yr-1 in the 578 000 km2 study area. This is ~ 31 % of the slated 45 km3 yr-1 water delivery in 2050 via the South-North Water Diversion Project. Analysis of relative LSC shows subsidence of 7.29 ± 0.35 mm yr-1 in Beijing and 2.74 ± 0.16 mm yr-1 in North China. About 11.53 % (2.74 ± 0.18 mm or 1.58 ± 0.12 km3) of the TWS and 8.37 % (1.52 ± 0.70 mm or 0.88 ± 0.03 km3) of the GWS are attributed to storage reductions accompanying subsidence in the region. Although interpretations of the findings require caution due to the short temporal and large spatial coverage, the concurrence of WSD and land subsidence could have adverse implications for the study area. It is critical that the relevant stakeholders embark on resource-efficient measures to ensure water availability, food security, ecological

  1. A distal renal tubular acidosis showing hyperammonemia and hyperlactacidemia

    Directory of Open Access Journals (Sweden)

    C. Ripoli

    2012-08-01

    Full Text Available Introduction: distal renal tubular acidosis (dRTA presents itself with variable clinical manifestations and often with late expressions that impact on prognosis. Case report: A 45-day-old male infant was admitted with stopping growth, difficult feeding and vomiting after meals. Clinical tests and labs revealed a type 1 renal tubular acidosis, even if the first blood tests showed ammonium and lactate increase. We had to exclude metabolic diseases before having a certain diagnosis. Conclusions: blood and urine investigations and genetic tests are fundamental to formulate dRTA diagnosis and to plan follow-up, according to possible phenotypic expressions of recessive and dominant autosomal forms in patients with dRTA.

  2. Impact Factors Show Increased Use of AGU Journals in 2008

    Science.gov (United States)

    Ford, Barbara Meyers

    2009-07-01

    The latest numbers released from Journal Citation Reports (JCR), published annually by Thomson Reuters, show large increases in the impact factor (IF) for several AGU journals. IFs are one way for publishers to know that readers have found their journals useful and of value in research. A journal's IF is calculated by taking the total number of citations to articles published by a given journal in the past 2 years and dividing it by the total number of papers published by the journal in the same time period. More generally, it can be seen as the frequency with which articles in a journal have been cited over the past year. The numbers speak for themselves (see Table 1).

  3. Case histories show real-time information reduces uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Meehan, R. [Schlumberger Cambridge Research, Cambridge, MA (United States); Nutt, L. [Schlumberger Wireline and Testing, Houston, TX (United States); Dutta, N. [BP Exploration, Houston, TX (United States); Menzies, J. [Lasmo plc, London (United Kingdom)

    1998-05-18

    Drill-bit seismic technology provides useful real-time information that reduces uncertainty for the driller. This second part of a two-part series provides real examples, describes the current state of technology and experience, and discusses techniques that will add value through the incorporation of additional information sources. To date, this technology has been used on more than 50 wells in all areas of the world, including a deepwater job in 1,200 m of water. As of March 1998, there were five ongoing jobs in Oman, Indonesia, Malaysia, Gulf of Mexico, and South America. The following examples of oil and gas wells demonstrate the application of the drill-bit seismic technique and show benefits that can be brought to the drilling process.

  4. THE HEROIC CULT IN RADIO SHOWS IN ROMANIA

    Directory of Open Access Journals (Sweden)

    Florica IUHAȘ

    2015-12-01

    Full Text Available A people’s cultural and historical past, represented as community’s destiny, is memorized and sent down, from one generation to the next, through the many channels of popular orality: legends, ballads, popular poetry and also through those chanels more specific to modern times, such as patriotic songs, cultivated poetry, fiction (especially historical novels, history, histories, films, etc. Through their educational purpose, but also through their emotional/affective packaging, all these do manage the collective past and determine the manner in which the historical time is perceived in a patromonial and affective fashion, as national past. The present study wishes to analyze the manner in which Romanian radio stations covered the events organized on the Heroes’ Day in 2014, to identify the themes of the radio coverage and to assess whether the current radio shows are able to ensure a memory link or connection between generations.

  5. Croton grewioides Baill. (Euphorbiaceae) Shows Antidiarrheal Activity in Mice

    Science.gov (United States)

    da Silva, Anne Dayse Soares; de Melo e Silva, Karoline; Neto, José Clementino; Costa, Vicente Carlos de Oliveira; Pessôa, Hilzeth de Luna F.; Tavares, Josean Fechine; da Silva, Marcelo Sobral; Cavalcante, Fabiana de Andrade

    2016-01-01

    Based on chemotaxonomy, we decided to investigate the possible antidiarrheal activity in mice of a crude ethanolic extract obtained from aerial parts of Croton grewioides (CG-EtOH). We tested for any possible toxicity in rat erythrocytes and acute toxicity in mice. Antidiarrheal activity was assessed by determining the effect of CG-EtOH on defecation frequency, liquid stool, intestinal motility and intestinal fluid accumulation. CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females. CG-EtOH produced a significant and equipotent antidiarrheal activity, both in defecation frequency (ED50 = 106.0 ± 8.1 mg/kg) and liquid stools (ED50 = 105.0 ± 9.2 mg/kg). However, CG-EtOH (125 mg/kg) decreased intestinal motility by only 22.7% ± 4.4%. Moreover, extract markedly inhibited the castor oil-induced intestinal contents (ED50 = 34.6 ± 5.4 mg/kg). We thus conclude that CG-EtOH is not orally lethal and contains active principles with antidiarrheal activity, and this effect seems to involve mostly changes in intestinal secretion. SUMMARY CG-EtOH showed no in vitro cytotoxicity and was not orally lethal. In contrast, the extract given intraperitoneally (at 2000 mg/kg) was lethal, but only in females.CG-EtOH probably contains active metabolites with antidiarrheal activity.CG-EtOH reduced the frequency and number of liquid stools.Metabolites presents in the CG-EtOH act mainly by reducing intestinal fluid and, to a lesser extent, reducing intestinal motility. Abbreviations Used: CG-EtOH: crude ethanolic extract obtained from the aerial parts of C. grewioides; WHO: World Health Organization; ED50: dose of a drug that produces 50% of its maximum effect; Emax: maximum effect PMID:27365990

  6. Pressure locking test results

    Energy Technology Data Exchange (ETDEWEB)

    DeWall, K.G.; Watkins, J.C.; McKellar, M.G.; Bramwell, D. [Idaho National Engineering Lab., Idaho Falls, ID (United States)] [and others

    1996-12-01

    The U.S. Nuclear Regulatory Commission (NRC), Office of Nuclear Regulatory Research, is funding the Idaho National Engineering Laboratory (INEL) in performing research to provide technical input for their use in evaluating responses to Generic Letter 95-07, {open_quotes}Pressure Locking and Thermal Binding of Safety-Related Power-Operated Gate Valves.{close_quotes} Pressure locking and thermal binding are phenomena that make a closed gate valve difficult to open. This paper discusses only the pressure locking phenomenon in a flexible-wedge gate valve; the authors will publish the results of their thermal binding research at a later date. Pressure locking can occur when operating sequences or temperature changes cause the pressure of the fluid in the bonnet (and, in most valves, between the discs) to be higher than the pressure on the upstream and downstream sides of the disc assembly. This high fluid pressure presses the discs against both seats, making the disc assembly harder to unseat than anticipated by the typical design calculations, which generally consider friction at only one of the two disc/seat interfaces. The high pressure of the bonnet fluid also changes the pressure distribution around the disc in a way that can further contribute to the unseating load. If the combined loads associated with pressure locking are very high, the actuator might not have the capacity to open the valve. The results of the NRC/INEL research discussed in this paper show that the relationship between bonnet pressure and pressure locking stem loads appears linear. The results also show that for this valve, seat leakage affects the bonnet pressurization rate when the valve is subjected to thermally induced pressure locking conditions.

  7. Improving co-located collaboration with show-through techniques

    OpenAIRE

    Argelaguet Sanz, Fernando; Kunert, André; Kulik, Alexander; Froehlich, Bernd

    2010-01-01

    Multi-user virtual reality systems enable natural interaction with shared virtual worlds. Users can talk to each other, gesture and point into the virtual scenery as if it were real. As in reality, referring to objects by pointing, results often in a situation whereon objects are occluded from the other users’ viewpoints. While in reality this problem can only be solved by adapting the viewing position, specialized individual views of the shared virtual scene enable various other solutions. A...

  8. The staff show their profound attachment to SLS

    CERN Multimedia

    Association du personnel

    2007-01-01

    The results of the poll on the Saved Leave Scheme (SLS) have now been analyzed and are published in this edition and on our web site. You were 1194 to reply to the questionnaire (approximately 50% of all staff members). The distribution of the replies according to certain variables (sex, age, career path, etc.) in the sample corresponds to the one observed for the overall staff population. This indicates that the sample is representative.

  9. Natural Product Shows Effectiveness in Combating Colorectal Cancer | Poster

    Science.gov (United States)

    An herbal extract used for centuries to prevent heart disease has now been shown to be effective against colorectal cancer when tested in laboratory cell cultures. Scientists from NCI at Frederick found that the natural extract cryptotanshinone (CPT) stops the uncontrolled cell growth characteristic of cancer by interfering with a protein that has been implicated in several cancers, including those of the colon and rectum. The results appear in the journal Molecular and Cellular Biochemistry.

  10. Adolescents with Autism Spectrum Disorder Show a Circumspect Reasoning Bias Rather than "Jumping-to-Conclusions"

    Science.gov (United States)

    Brosnan, Mark; Chapman, Emma; Ashwin, Chris

    2014-01-01

    People with autism spectrum disorders (ASD) often take longer to make decisions. The Autism-Psychosis Model proposes that people with autism and psychosis show the opposite pattern of results on cognitive tasks. As those with psychosis show a jump-to-conclusions reasoning bias, those with ASD should show a circumspect reasoning bias.…

  11. Film showing - Higgs: into the heart of imagination

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    On 29 April at 7pm Dutch filmmakers, Hannie van den Bergh and Jan van den Berg, will introduce their directorial debut, Higgs: into the heart of imagination in CERN’s Main Auditorium.   This documentary is about the curiousity, passion and imaginative powers of science. Featuring physicists working at CERN, in particular in ATLAS, and filmed over four years, the film-makers have created a cinematic journey into the heart of imagination. They follow Stan Bentvelsen, head of the Dutch research group at CERN, and watch as he prepares his team for the start of the LHC, as well as the scientific competition to find the elusive Higgs particle. The film also features Peter Higgs as he discusses his work from 1964. The directors have created theatre productions and other multimedia projects under the title The Imagination of Invisible Dimensions, which allow for adventurous dialogues between art and science. All are welcome to attend this showing and afterwards there will be a short question...

  12. Transcriptome characterization of Ishige okamurae (Phaeophyceae) shows strong environmental acclimation

    Institute of Scientific and Technical Information of China (English)

    QU Jieqiong; WANG Xumin; CHI Shan; WU Shuangxiu; SUN Jing; LIU Cui; CHEN Shengping; YU Jun; LIU Tao

    2014-01-01

    Ishige okamurae, with leathery branched narrow fronds consisting of cylindrical hairs, is the typical species of the genus Ishige, which is considered as one of the most basal genera in the phylogeny of the Phaeophy-ceae. Apart from great public interest from the evolutionary respect, more attention has been brought on the abundant bioactive compounds in I. okamurae for therapeutic or economic considerations, such as di-phlorethohydroxycarmalol and ishigoside. Yet little is known about related key genes or metabolic pathways involved in I. okamurae, which calls upon us to carry out global analyses of transcriptome by next generation sequencing. Altogether, we obtained 78 583 assembled scaffolds with N50 of 1 709 nucleotides, and 25 357 unigenes with significant BLAST matches (E-value cutoff of 10-5). In terms of characterization of the tran-scriptome of I. okamurae, we focused on anti-stress metabolic pathways and synthetic routes of bioactive compounds in an attempt to obtain a better understanding of the interactive organism-environment regula-tory networks. Pathway-based analysis helped us to deepen our comprehension of the interaction between I. okamurae and its surroundings, with MAPK signal pathway as an example. Furthermore, we discovered a wide range of novel putative functional proteins that could be of wide application, such as Rab family, using sequence-based transcriptome. In conclusion, transcriptome characterization of I. okamurae (Phaeophy-ceae) shows strong environmental acclimation.

  13. Show: Dr. H, the life and death of pancakes

    CERN Multimedia

    2012-01-01

    Dr. H, the life and death of pancakes, a comic theatrical creation, written and performed by Heiko Buchholz.   Monday 2 April 2012 in German Tuesday 3 April 2012 in English Wednesday 4 April 2012 in French 8:30 p.m. at the Globe of Science and Innovation. This production takes a comic look at scientific methods, as applied to a common object: the pancake. More specifically, Dr H. regales his audience with statistics, experiments and scientific data surrounding this egg-and-milk-based culinary delight. And although these zany sketches are nothing short of absurd, the audience is drawn in more often than you might expect… and taken on quite an unexpected journey into the behavioural disorders, personality quirks and psychoanalysis of the base pancake. This show playfully mocks scientific logic and discourse, forcing the audience to reflect on their gullibility in the face of science and its impenetrable jargon. It purports to be neither explanation nor illustration of scientific fact,...

  14. Coagulation tests show significant differences in patients with breast cancer.

    Science.gov (United States)

    Tas, Faruk; Kilic, Leyla; Duranyildiz, Derya

    2014-06-01

    Activated coagulation and fibrinolytic system in cancer patients is associated with tumor stroma formation and metastasis in different cancer types. The aim of this study is to explore the correlation of blood coagulation assays for various clinicopathologic factors in breast cancer patients. A total of 123 female breast cancer patients were enrolled into the study. All the patients were treatment naïve. Pretreatment blood coagulation tests including PT, APTT, PTA, INR, D-dimer, fibrinogen levels, and platelet counts were evaluated. Median age of diagnosis was 51 years old (range 26-82). Twenty-two percent of the group consisted of metastatic breast cancer patients. The plasma level of all coagulation tests revealed statistically significant difference between patient and control group except for PT (p50 years) was associated with higher D-dimer levels (p=0.003). Metastatic patients exhibited significantly higher D-dimer values when compared with early breast cancer patients (p=0.049). Advanced tumor stage (T3 and T4) was associated with higher INR (p=0.05) and lower PTA (p=0.025). In conclusion, coagulation tests show significant differences in patients with breast cancer.

  15. A structural approach in networks: showing patterns, possibilities and pitfalls

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Alves

    2010-01-01

    Full Text Available In recent years there has been a noticeable shift in evaluation paradigms away from positivist, individualist and atomistic explanations of phenomena to those seeking a more relational, contextual and systemic understanding. This growing shift in interest to the interrelationships or networks of connections between entities is apparent in fields as organizations in networks, knowledge transmission between social groups and so. A growing theoretical and methodological base is providing enhanced capacities to uncover the actual topologies or patterns of connections between entities, elements, people, organizations or communities and deliver a more fine grained analysis of their elements. In this way network analysis differs from conventional evaluation and research modes since its focus is on the interrelationships of entities not the characteristics of individuals. In this paper, we review and analyze the emerging capacity of the network paradigm as an evaluation method and show how this model can be applied t a range of evaluation arenas. In doing so, we outline a framework to guide network evaluation, establish some key network indicators and highlight key methodological aspects and pitfalls.

  16. Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate.

    Science.gov (United States)

    Rakheja, Dinesh; Boriack, Richard L; Mitui, Midori; Khokhar, Shama; Holt, Shelby A; Kapur, Payal

    2011-04-01

    Elevated levels of D: -2-hydroxyglutarate (D: -2-HG) occur in gliomas and myeloid leukemias associated with mutations of IDH1 and IDH2. L: -2-Hydroxyglutaric aciduria, an inherited metabolic disorder, predisposes to brain tumors. Therefore, we asked whether sporadic cancers, without IDH1 or IDH2 hot-spot mutations, show elevated 2-hydroxyglutarate levels. We retrieved 15 pairs of frozen papillary thyroid carcinoma (PTC) and adjacent non-neoplastic thyroid, and 14 pairs of hyperplastic nodule (HN) and adjacent non-hyperplastic thyroid. In all lesions, exon 4 sequencing confirmed the absence of known mutations of IDH1 and IDH2. We measured 2-hydroxyglutarate by liquid chromatography-tandem mass spectrometry. Compared to normal thyroid, PTCs had significantly higher D: -2-HG and L: -2-hydroxyglutarate (L: -2-HG) levels, and compared to HNs, PTCs had significantly higher D: -2-HG levels. D: -2-HG/L: -2-HG levels were not significantly different between HNs and normal thyroid. Further studies should clarify if elevated 2-hydroxyglutarate in PTC may be useful as cancer biomarker and evaluate the role of 2-hydroxyglutarate in cancer biology.

  17. Maps showing seismic landslide hazards in Anchorage, Alaska

    Science.gov (United States)

    Jibson, Randall W.

    2014-01-01

    The devastating landslides that accompanied the great 1964 Alaska earthquake showed that seismically triggered landslides are one of the greatest geologic hazards in Anchorage. Maps quantifying seismic landslide hazards are therefore important for planning, zoning, and emergency-response preparation. The accompanying maps portray seismic landslide hazards for the following conditions: (1) deep, translational landslides, which occur only during great subduction-zone earthquakes that have return periods of =300-900 yr; (2) shallow landslides for a peak ground acceleration (PGA) of 0.69 g, which has a return period of 2,475 yr, or a 2 percent probability of exceedance in 50 yr; and (3) shallow landslides for a PGA of 0.43 g, which has a return period of 475 yr, or a 10 percent probability of exceedance in 50 yr. Deep, translational landslide hazards were delineated based on previous studies of such landslides, with some modifications based on field observations of locations of deep landslides. Shallow-landslide hazards were delineated using a Newmark-type displacement analysis for the two probabilistic ground motions modeled.

  18. Earthquake data visualization shows ground motion in real time

    Science.gov (United States)

    Schultz, Colin

    2011-12-01

    On 11 March 2011 a magnitude 9.0 earthquake shattered the seabed off the eastern coast of Japan's Honshu Island. Visualizations of scientific data showing the peaks of a seismograph or maps overlain with the locations and magnitudes of the earthquake and its numerous aftershocks were brought out to help explain the devastation to the public. While dramatic, such displays can be difficult for the public to interpret clearly because people have trouble trying to picture what the recordings of a seismograph might look like on the ground or because they have trouble understanding the logarithmic relationship between earthquake magnitude and energy. Drawing on the three-dimensional position records of a dense web of high-frequency GPS ground receiver stations, Grapenthin and Freymueller developed an animation of the abrupt horizontal and vertical motions that pulled parts of the country more than 4 meters to the east and sank large portions of its eastern shore more than half a meter into the sea.

  19. Quantifying causal emergence shows that macro can beat micro.

    Science.gov (United States)

    Hoel, Erik P; Albantakis, Larissa; Tononi, Giulio

    2013-12-01

    Causal interactions within complex systems can be analyzed at multiple spatial and temporal scales. For example, the brain can be analyzed at the level of neurons, neuronal groups, and areas, over tens, hundreds, or thousands of milliseconds. It is widely assumed that, once a micro level is fixed, macro levels are fixed too, a relation called supervenience. It is also assumed that, although macro descriptions may be convenient, only the micro level is causally complete, because it includes every detail, thus leaving no room for causation at the macro level. However, this assumption can only be evaluated under a proper measure of causation. Here, we use a measure [effective information (EI)] that depends on both the effectiveness of a system's mechanisms and the size of its state space: EI is higher the more the mechanisms constrain the system's possible past and future states. By measuring EI at micro and macro levels in simple systems whose micro mechanisms are fixed, we show that for certain causal architectures EI can peak at a macro level in space and/or time. This happens when coarse-grained macro mechanisms are more effective (more deterministic and/or less degenerate) than the underlying micro mechanisms, to an extent that overcomes the smaller state space. Thus, although the macro level supervenes upon the micro, it can supersede it causally, leading to genuine causal emergence--the gain in EI when moving from a micro to a macro level of analysis.

  20. Information literacy is not a one-man show

    DEFF Research Database (Denmark)

    Bønløkke, Mette; Kobow, Else; Kristensen, Anne-Kirstine Østergaard

    2015-01-01

    to the other’s understanding of IL, the curriculum, pedagogical professionalism and mutual roles. A joint conceptual understanding of IL is important for making this teamwork work. Librarians need access to programme documents and knowledge on students’ level of learning and on course work. Co...... programmes have not integrated IL into the curriculum nor have they established a formalised cooperation between library and faculty on IL. Participants in the project were three librarians, six lecturers, one library manager, two directors of programme and two project managers from VIA University College......, Denmark. The data for this study originates from focus group interviews, process protocols, records of reflective sessions and support meetings as well as from mail correspondences. Results indicate that formal cooperation between librarians and educators is necessary and provides the needed access...

  1. Temperatures of galactic molecular clouds showing CO self-absorption

    Science.gov (United States)

    Phillips, T. G.; Knapp, G. R.; Wannier, P. G.; Huggins, P. J.; Werner, M. W.; Neugebauer, G.; Ennis, D.

    1981-01-01

    The CO J = 2-1 line has been observed and, in most cases, mapped in 10 star-forming molecular clouds (W3, NGC 1333, NGC 2071, Mon R2, CRL 961, Rho Oph, W49N, W51A, DR 21, and Cep A). The CO J = 3-2 line has been observed in W3 and DR 21. The CO lines from all these sources are strongly self-absorbed. By comparing the present results with published CO(1-0) line profiles, it is found that large corrections to the temperatures of the cloud cores, as measured by the CO(1-0) lines, are required. The corrections for self-absorption bring the CO brightness temperatures into closer agreement with the grain temperatures inferred from far-IR photometry.

  2. Advertising Discourse Analysis of FES stores: Killing Love, Cowards Show

    Directory of Open Access Journals (Sweden)

    Cristian Venegas Ahumada

    2013-08-01

    Full Text Available The objective is to analyze the structural and photographic discourse of the Autumn-Winter campaign 2008 of FES stores for young people. This was done by a semiotic theory and a critical-structural methodology of discourse. An analysis of 4 advertising photographs was done, and at once an analysis of the discourse “FES says no to violence against Women”, which explains the campaign’s target. The result is: The discourse was subjected to production condition (society of control and makes advertising a way to homogenize subjectivity of masses to consume. Recognition conditions demonstrate that this advertising discourse of symbolic violence means a type of violation of Men and Women Rights. An action like this requires commitment of Psychology in order to promote the social humanizing change, by means of university teaching and professional tasks.

  3. Neutrino Radiation Showing a Christodoulou Memory Effect in General Relativity

    CERN Document Server

    Bieri, Lydia

    2013-01-01

    We describe neutrino radiation in general relativity by introducing the energy-momentum tensor of a null fluid into the Einstein equations. Investigating the geometry and analysis at null infinity, we prove that a component of the null fluid enlarges the Christodoulou memory effect of gravitational waves. The description of neutrinos in general relativity as a null fluid can be regarded as a limiting case of a more general description using the massless limit of the Einstein-Vlasov system. The present authors with co-authors have work in progress to generalize the results of this paper using this more general description. Gigantic neutrino bursts occur in our universe in core-collapse supernovae and in the mergers of neutron star binaries.

  4. Information literacy is not a one-man show

    DEFF Research Database (Denmark)

    Bønløkke, Mette; Kobow, Else; Kristensen, Anne-Kirstine Østergaard

    2015-01-01

    -teaching supports the librarian in developing pedagogical skills. Educators have diverging experiences with IL which can be a problem when challenging students on IL for their assignments. IL is everyone’s business and local dissemination of an agreed curriculum intervention throughout a programme is important......, Denmark. The data for this study originates from focus group interviews, process protocols, records of reflective sessions and support meetings as well as from mail correspondences. Results indicate that formal cooperation between librarians and educators is necessary and provides the needed access...... to the other’s understanding of IL, the curriculum, pedagogical professionalism and mutual roles. A joint conceptual understanding of IL is important for making this teamwork work. Librarians need access to programme documents and knowledge on students’ level of learning and on course work. Co...

  5. Results of hip resurfacing

    Science.gov (United States)

    Favetti, Fabio; Casella, Filippo; Papalia, Matteo; Panegrossi, Gabriele

    2011-01-01

    Background The renewed popularity of resurfacing hip arthroplasty in the last 10 years has generated a remarkable quantity of scientific contributions based on mid- and short-term follow-up. More than one paper has reported a consistent early revision rate as a consequence of biological or biomechanical failure. Two major complications are commonly described with resurfacing implants: avascular necrosis and femoral-neck fracture. A close relationship between these two events has been suggested, but not firmly demonstrated, whereas cementing technique seems to be better understood as potential cause of failure. Methods We performed an in vitro study in which four different resurfacing implants were evaluated with a simulated femoral head, two types of cement, (low and high viscosity) and two cementing techniques: direct (cement apposition directly on the femoral head) and indirect (cement poured into the femoral component). Results High-viscosity cement showed homogeneous distribution over the entire femoral head. Low-viscosity cement showed a massive polar concentration with insufficient, if not absent, distribution in the equatorial zone. Conclusion Polar cement concentration could be a risk factor for early implant failure due to two effects on the femoral head: biological (excessive local exothermic reaction could cause osteocyte necrosis) and biomechanical (which could lead to uneven load distribution on the femoral head). PMID:21234563

  6. Dogs Do Not Show Pro-social Preferences towards Humans

    Science.gov (United States)

    Quervel-Chaumette, Mylène; Mainix, Gaëlle; Range, Friederike; Marshall-Pescini, Sarah

    2016-01-01

    Pro-social behaviors are defined as voluntary actions that benefit others. Comparative studies have mostly focused on investigating the presence of pro-sociality across species in an intraspecific context. Taken together, results on both primates and non-primate species indicate that reliance on cooperation may be at work in the selection and maintenance of pro-social sentiments. Dogs appear to be the ideal model when investigating a species’ propensity for pro-sociality in an interspecific context because it has been suggested that as a consequence of domestication, they evolved an underlying temperament encouraging greater propensity to cooperate with human partners. In a recent study, using a food delivery paradigm, dogs were shown to preferentially express pro-social choices toward familiar compared to unfamiliar conspecifics. Using the same set-up and methods in the current study, we investigated dogs’ pro-social preferences toward familiar and unfamiliar human partners. We found that dogs’ pro-social tendencies did not extend to humans and the identity of the human partners did not influence the rate of food delivery. Interestingly, dogs tested with their human partners spent more time gazing at humans, and did so for longer after food consumption had ended than dogs tested with conspecific partners in the initial study. To allow comparability between results from dogs tested with a conspecific and a human partner, the latter were asked not to communicate with dogs in any way. However, this lack of communication from the human may have been aversive to dogs, leading them to cease performing the task earlier compared to the dogs paired with familiar conspecifics in the prior study. This is in line with previous findings suggesting that human communication in such contexts highly affects dogs’ responses. Consequently, we encourage further studies to examine dogs’ pro-social behavior toward humans taking into consideration their potential responses

  7. Contaminants in tracked seabirds showing regional patterns of marine pollution.

    Science.gov (United States)

    Ito, Atsuo; Yamashita, Rei; Takada, Hideshige; Yamamoto, Takashi; Shiomi, Kozue; Zavalaga, Carlos; Abe, Tomoya; Watanabe, Shinichi; Yamamoto, Maki; Sato, Katsufumi; Kohno, Hiroyoshi; Yoda, Ken; Iida, Tomohiko; Watanuki, Yutaka

    2013-07-16

    Ocean-scale monitoring of pollution is challenging. Seabirds are useful indicators because they travel over a broad foraging range. Nevertheless, this coarse spatial resolution is not fine enough to discriminate pollution in a finer scale. Previous studies have demonstrated that pollution levels are higher in the Sea of Japan and South and East China Seas than the Northen Pacific Ocean. To test these findings in a wide-ranging animal, we tracked streaked shearwaters (Calonectris leucomelas) from four islands in Japan using global positioning system (GPS) and measured persistent organic pollutants (POPs) in the oil of their preen glands. The POPs did not change during 6 to 21 days when birds from Awashima were foraging only in the Sea of Japan, while it increased when they crossed to the Pacific through the Tsugaru Strait and foraged along the eastern coast of Hokkaido where industrial cities occur. These results indicate that POPs in the oil reflect relatively short-term exposure. Concentrations of POPs displayed greater variation among regions. Total polychlorinated biphenyls were highest in birds foraging in a small area of the semiclosed Seto Inland Sea surrounded by urbanized coast, p,p'-dichlorodiphenyltrichloroethane (DDT) was highest in birds foraging in the East China Sea, and total hexachlorocyclohexanes were highest in birds foraging in the Sea of Japan. All were lowest in birds foraging in the Pacific. This distribution of POPs concentration partly agrees with previous findings based on mussels, fish, and seawater and possibly reflects the mobility and emission sources of each type of POP. These results highlight the importance of information on the foraging area of highly mobile top predators to make them more effective monitors of regional marine pollution.

  8. A paradox of syntactic priming: Why response tendencies show priming for passives, and response latencies show priming for actives

    OpenAIRE

    Corley, M.; Segaert, K.; Menenti, L.; Weber, K.; Hagoort, P.

    2011-01-01

    Speakers tend to repeat syntactic structures across sentences, a phenomenon called syntactic priming. Although it has been suggested that repeating syntactic structures should result in speeded responses, previous research has focused on effects in response tendencies. We investigated syntactic priming effects simultaneously in response tendencies and response latencies for active and passive transitive sentences in a picture description task. In Experiment 1, there were priming effects in re...

  9. "The show must go on!" Beserings van dramastudente tydens opleiding

    Directory of Open Access Journals (Sweden)

    J Deacon

    2009-03-01

    Full Text Available "THE SHOW MUST GO ON!" LIABILITY WHEN IT COMES TO DRAMA STUDENTS WHEN INJURED WHILE IN TRAININGThis article emphasises the uncertainty in the relationship between a student undergoing practical training and his/her lecturer or university, if the student should be injured and wants to claim compensation. One must first establish whether the student can be described as an employee of the lecturer or university, or as a vocational worker or independent contractor. Once the status of the student has been established, the relevant legislation can be determined, whether it is the Labour Relations Act or the Basic Conditions of Employment. It is, however, not that simple and a person in the capacity of a student does not accord with the definition of an employee or an independent contractor or a vocational worker. One will have to rely on the assumption in section 83A in the Basic Conditions of Employment that a student is an employee when he does practical training for the benefit of the university. The Occupational Health and Safety Act requires employers to assure that the workplace is a safe environment for employees, with the minimum risks involved. The Compensation for Occupational Injuries and Diseases Act makes it possible for an employee to claim compensation when such a risk becomes a reality.This article also tries to compare the situation of a student sports person injured while participating in university sports, and a drama student injured during a performance or rehearsal of a play. It is stated that the relationship between the drama student and lecturer is similar to the relationship between a sports person and his/her coach, but the relationship differs in that a sports person’s risk of getting hurt is much greater than that of a drama student, The contracts between sports players and their authorities are also stipulated in much more detail than the contracts (if any between the drama students and the university. It is concluded

  10. Anger, Cognition, Ideology: What Crash Can Show Us About Emotion

    Directory of Open Access Journals (Sweden)

    Sue J. Kim

    2010-06-01

    Full Text Available

    Abstract (E: Sue J. Kim’s essay “Anger, Cognition, Ideology: What Crash Can Show Us About Emotion” argues for the relevance and importance of cognitive studies to ethnic and postcolonial literary studies, and vice versa. After surveying recent developments in the field of cognitive studies, the essay combines cultural and cognitive approaches in order to examine anger in and around the 2005 Paul Haggis film Crash.

     

    Abstract (F: Dans cet article, l’auteur fait un plaidoyer pour l’application des études cognitives aux études ethniques et postcoloniales et inversement. L’essai présente d’abord un survol des récents développements dans le domaine des études cognitives, puis combine les approches culturelles et cognitives dans une lecture détaillée du thème de la colère dans le film Crash de Paul Haggis (2005.

     

  11. Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning.

    Science.gov (United States)

    Schultz, Douglas H; Balderston, Nicholas L; Baskin-Sommers, Arielle R; Larson, Christine L; Helmstetter, Fred J

    2016-01-01

    Psychopathy is a personality disorder characterized by emotional deficits and a failure to inhibit impulsive behavior and is often subdivided into "primary" and "secondary" psychopathic subtypes. The maladaptive behavior related to primary psychopathy is thought to reflect constitutional "fearlessness," while the problematic behavior related to secondary psychopathy is motivated by other factors. The fearlessness observed in psychopathy has often been interpreted as reflecting a fundamental deficit in amygdala function, and previous studies have provided support for a low-fear model of psychopathy. However, many of these studies fail to use appropriate screening procedures, use liberal inclusion criteria, or have used unconventional approaches to assay amygdala function. We measured brain activity with BOLD imaging in primary and secondary psychopaths and non-psychopathic control subjects during Pavlovian fear conditioning. In contrast to the low-fear model, we observed normal fear expression in primary psychopaths. Psychopaths also displayed greater differential BOLD activity in the amygdala relative to matched controls. Inverse patterns of activity were observed in the anterior cingulate cortex (ACC) for primary versus secondary psychopaths. Primary psychopaths exhibited a pattern of activity in the dorsal and ventral ACC consistent with enhanced fear expression, while secondary psychopaths exhibited a pattern of activity in these regions consistent with fear inhibition. These results contradict the low-fear model of psychopathy and suggest that the low fear observed for psychopaths in previous studies may be specific to secondary psychopaths.

  12. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency.

    Science.gov (United States)

    Ohno, Yohei; Yuasa, Shinsuke; Egashira, Toru; Seki, Tomohisa; Hashimoto, Hisayuki; Tohyama, Shugo; Saito, Yuki; Kunitomi, Akira; Shimoji, Kenichiro; Onizuka, Takeshi; Kageyama, Toshimi; Yae, Kojiro; Tanaka, Tomofumi; Kaneda, Ruri; Hattori, Fumiyuki; Murata, Mitsushige; Kimura, Kensuke; Fukuda, Keiichi

    2013-01-01

    Patient-specific induced pluripotent stem (iPS) cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells. Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general versatility, it remains unknown which types of iPS cells are suitable for clinical use. Therefore, the aims of the present study were to assess (1) the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro and (2) the properties of the iPS cell-derived cardiomyocytes. We found that high-quality iPS cells exhibited better cardiomyocyte differentiation in terms of the time course and efficiency of differentiation than low-quality iPS cells, which hardly ever differentiated into cardiomyocytes. Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.

  13. [Interferon alpha antibodies show no cross reactions with typical autoantibodies].

    Science.gov (United States)

    Görg, S; Klouche, M; Wilhelm, D; Kirchner, H

    1993-04-01

    Patients treated with natural human interferon alpha develop anti-interferon antibodies (IFN-AB) only in very rare cases. By contrast, patients with autoimmune disorders are able to generate high-titered IFN-AB against endogenous interferon alpha. One explanation for the development of auto-IFN-AB could be cross-reactivity with typical autoimmune antigens. We investigated the cross-reactivity of 3 high-titered IgG IFN-AB of female autoimmune patients (aged 32, 36, 74 years; two severe cases of SLE, one case of autoimmune thyroiditis) as well as 25 low-titered natural IgM IFN-AB of healthy blood donors (aged 19-48 years). Typical autoimmune antigens including dsDNA, ENA, as well as natural interferon beta and recombinant interferon gamma are not able to inhibit binding of IFN-AB to interferon alpha in an ELISA test system. Preincubation of sera containing either dsDNA antibodies (dsDNA-AB) (24 patients), thyroid peroxidase (TPO-AB) (9 patients) or thyroglobulin (TG-AB) (12 patients) with interferon alpha resulted in no change in the respective autoantibody titer. These data suggest that there is no cross-reactivity between IFN-alpha-AB and dsDNA-AB, TPO-AB or TG-AB. Thus, an explanation for the occurrence of IFN-AB in autoimmune disorders cannot be found in a cross-reaction between interferon alpha with typical autoimmune antigens.

  14. Capuchin monkeys do not show human-like pricing effects

    Directory of Open Access Journals (Sweden)

    Rhia eCatapano

    2014-12-01

    Full Text Available Recent work in judgment and decision-making has shown that a good’s price can have irrational effects on people’s preferences. People tend to prefer goods that cost more money and assume that such expensive goods will be more effective, even in cases where the price of the good is itself arbitrary. Although much work has documented the existence of these pricing effects, unfortunately little work has addressed where these price effects come from in the first place. Here we use a comparative approach to distinguish between different accounts of this bias and to explore the origins of these effects. Specifically, we test whether brown capuchin monkeys (Cebus apella are also susceptible to pricing effects within the context of an experimentally trained token economy. Using a capuchin population previously trained in a token market, we explored whether monkeys used price as an indicator of value across four experiments. Although monkeys demonstrated an understanding of which goods had which prices (consistently shifting preferences to cheaper goods when prices were increased, we observed no evidence that such price information affected their valuation of different kinds of goods. These results suggest that human price effects may involve more sophisticated human-unique cognitive capacities, such as an understanding of market forces and signaling.

  15. Distinct iPS Cells Show Different Cardiac Differentiation Efficiency

    Directory of Open Access Journals (Sweden)

    Yohei Ohno

    2013-01-01

    Full Text Available Patient-specific induced pluripotent stem (iPS cells can be generated by introducing transcription factors that are highly expressed in embryonic stem (ES cells into somatic cells. This opens up new possibilities for cell transplantation-based regenerative medicine by overcoming the ethical issues and immunological problems associated with ES cells. Despite the development of various methods for the generation of iPS cells that have resulted in increased efficiency, safety, and general versatility, it remains unknown which types of iPS cells are suitable for clinical use. Therefore, the aims of the present study were to assess (1 the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro and (2 the properties of the iPS cell-derived cardiomyocytes. We found that high-quality iPS cells exhibited better cardiomyocyte differentiation in terms of the time course and efficiency of differentiation than low-quality iPS cells, which hardly ever differentiated into cardiomyocytes. Because of the different properties of the various iPS cell lines such as cardiac differentiation efficiency and potential safety hazards, newly established iPS cell lines must be characterized prior to their use in cardiac regenerative medicine.

  16. Psychopaths show enhanced amygdala activation during fear conditioning

    Directory of Open Access Journals (Sweden)

    Douglas eSchultz

    2016-03-01

    Full Text Available Psychopathy is a personality disorder characterized by emotional deficits and a failure to inhibit impulsive behavior and is often subdivided into primary and secondary psychopathic subtypes. The maladaptive behavior related to primary psychopathy is thought to reflect constitutional fearlessness, while the problematic behavior related to secondary psychopathy is motivated by other factors. The fearlessness observed in psychopathy has often been interpreted as reflecting a fundamental deficit in amygdala function, and previous studies have provided support for a low-fear model of psychopathy. However, many of these studies fail to use appropriate screening procedures, use liberal inclusion criteria, or have used unconventional approaches to assay amygdala function. We measured brain activity with BOLD imaging in primary and secondary psychopaths and non-psychopathic control subjects during Pavlovian fear conditioning. In contrast to the low-fear model, we observed normal fear expression in primary psychopaths. Psychopaths also displayed greater differential BOLD activity in the amygdala relative to matched controls. Inverse patterns of activity were observed in the anterior cingulate cortex (ACC for primary versus secondary psychopaths. Primary psychopaths exhibited a pattern of activity in the dorsal and ventral ACC consistent with enhanced fear expression, while secondary psychopaths exhibited a pattern of activity in these regions consistent with fear inhibition. These results contradict the low-fear model of psychopathy and suggest that the low fear observed for psychopaths in previous studies may be specific to secondary psychopaths.

  17. Energetic radiation belt electron precipitation showing ULF modulation

    Science.gov (United States)

    Brito, T. V.; Hudson, M. K.; Kress, B. T.

    2012-12-01

    The energization and loss processes for energetic radiation belt electrons are not yet well understood. Ultra Low Frequency (ULF) waves have been correlated with both enhancement in outer zone radiation belt electron flux and modulation of precipitation loss to the atmosphere. This study considers the effects of ULF waves in the Pc-4 to Pc-5 range on electron loss to the atmosphere on a time scale of several minutes. Global simulations using magnetohydrodynamics (MHD) model fields as drivers provide a valuable tool for studying the dynamics of these ˜MeV energetic particles. ACE satellite measurements of the MHD solar wind parameters are used as the upstream boundary condition for the Lyon-Fedder-Mobarry (LFM) 3D MHD code calculation of fields, used to drive electrons in a 3D test particle simulation that keeps track of attributes like energy, pitch-angle and L-shell. The simulation results are compared with balloon observations obtained during the January 21, 2005 CME-shock event. Rapid loss of 20~keV to 1.5~MeV electrons was detected by balloon-borne measurements of Bremsstrahlung X-rays during the MINIS balloon campaign following the shock arrival at Earth. The global response of the radiation belts to this particular CME-shock driven storm was investigated focusing on precipitation mechanisms by which ULF waves, seen both in the simulations and observations influence the radiation belt population. A primary cause for the precipitation modulation seen in both the simulation and the MINIS campaign is suggested based on the lowering of mirror points due to compressional magnetic field oscillations.

  18. Cholesterol testing and results

    Science.gov (United States)

    Cholesterol test results; LDL test results; VLDL test results; HDL test results; Coronary risk profile results; Hyperlipidemia- ... Some cholesterol is considered good and some is considered bad. Different blood tests can be done to measure each ...

  19. Report on Results 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This report discusses work being carried out in Norway to promote energy efficiency and the production of new renewable energy. An overall review of the quantifiable results of last year's activities at national level is available. It will serve to initiate an annual reporting tradition. The report represents a step towards an ongoing process for improved targeting and management of national efforts. During the course of the year 2000, NVE has evaluated and adjusted its activities and established a system involving indicators and reporting procedures. It is also important to take notice of the long-term work being undertaken to influence people's attitudes, even though this work is difficult to assess. NVE is investing in i.a. measures aimed at children and young people. Apart from directly influencing future energy users, this investment is also having an effect due to the children's encouragement of their parents to engage in more energy and environment-friendly behaviour. Published in 2000, the IEA report ''Trends in Norwegian Stationary Energy Use'' shows that total Norwegian energy consumption per GDP is not much higher than in other IEA countries, when adjusted for cold climate and industrial structure. However, Norwegians do stand out as intensive users of electricity. The IEA report shows a reduction of 10 TWh in energy usage when compared to the projected post 1990 figures. Energy efficiency activities have contributed towards this reduction. However, the potential for a more rational use of energy in Norway is still substantial and well documented. Based on experience most enterprises could save around 10% of energy used just by making changes to their operations, i.e. without major investments. Furthermore, the potential is growing because of massive technological developments in respect of energy usage, production and distribution. With this in mind, it is necessary to take full advantage of the extensive knowledge

  20. Results from LHCf Experiment

    Directory of Open Access Journals (Sweden)

    Tricomi Alessia

    2012-06-01

    Full Text Available The LHCf experiment has taken data in 2009 and 2010 p-p collisions at LHC at √s = 0.9 TeV and √s = 7 TeV. The measurement of the forward neutral particle spectra produced in proton-proton collisions at LHC up to an energy of 14 TeV in the center of mass system are of fundamental importance to calibrate the Monte Carlo models widely used in the high energy cosmic ray (HECR field, up to an equivalent laboratory energy of the order of 1017 eV. In this paper the first results on the inclusive photon spectrum measured by LHCf is reported. Comparison of this spectrum with the model expectations show significant discrepancies, mainly in the high energy region. In addition, perspectives for future analyses as well as the program for the next data taking period, in particular the possibility to take data in p-Pb collisions, will be discussed.

  1. New results from VES

    CERN Document Server

    Dorofeev, V A

    1999-01-01

    The results of the patial wave analysis(PWA) of the pi+pi-pi- and omegapi-pi0 systems are presented. The a3 and a4(2040) signals are observed in the rho(770)pi and f2(1270)pi channels. Indications of the a1' meson existence was found in the 1+0+ rhopi S-wave. The decay branching ratio of the a2(1320)- to omegapi-pi0 was measured. The 2+1+ wave shows a broad bump at M~1.7GeV. The decays of the pi2(1670), a4(2040) and pi(1740) into omegarho- were found. The resonance in the b1(1235)pi wave with exotic quantum numbers jpc=1-+ at M~1.6 is observed and the simultaneous analysis of the 1-+ wave in the b1(1235)pi, etha'pi and rhopi final states is presented.

  2. Soft show

    OpenAIRE

    Goitia Cruz, Aitor

    2010-01-01

    El artículo señala la ausencia de debate en torno a la proliferación de arquitecturas-esculturas derivadas de un manierismo sustentado en las nuevas aplicaciones informáticas, capaces de generar geometrías complejas de suaves contornos.

  3. FASHION SHOW

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Star Wars x adidas香港星际大战活动展开adidas Originals系列即将在2010春夏发表的星际大战Star Wars系列商品,在先前已经为各位做过相当多的系列报导,而这次的联名盛事也即将在香港举办活动,本回找来星战迷的头号世界组织501 st Legion来合作,一系列相当有趣的照片,像是黑武士Darth Vader在香港街头以及帝国兵在茶餐厅用餐的kuso画面,都有部分的释出,而他们也都换上了本次的联名鞋款以及装备于其中,相当震撼。

  4. TIGER SHOW

    Institute of Scientific and Technical Information of China (English)

    周洁

    2002-01-01

    TIGER SHOW时间——二零零七月八号。TIGER SHOW地点——厦门电视台四百坪演播大厅。TIGER SHOW原因——庆祝幼儿园两周岁生曰,参加这次演出的还有幼儿园里其他许多的小朋友,他们都是那么可爱。

  5. What Makes the Difference? Pop Music Stars and TV Talent Show Contestants in Adolescents' Judgements

    OpenAIRE

    Lothwesen, Kai; Müllensiefen, Daniel

    2005-01-01

    This paper summarises the approach, empirical methodologies, and part of the results of an empirical study that was conducted in early 2004, when musical TV talent shows reached their peak popularity among young media audiences in Germany. Our primary research interest was in the similarities and differences that the adolescent target group of this TV format might perceive between contestants in TV talent shows and real or ordinary pop music stars. Shows in this TV format all seem to...

  6. RESULTS RESULTING FROM AUTOFRETTAGE OF CYLINDER

    Institute of Scientific and Technical Information of China (English)

    ZHU Ruilin

    2008-01-01

    Autofrettage is used to introduce advantageous residual stresses into wall of a cylinder and to even distributions of total stresses. Basic theory on autofrettage has been functioning for several decades. It is necessary to reveal profound relations between parameters in the theory. Therefore, based on the 3rd strength theory, δei/δy, δei/δy, δei′/δy, δei′/δy and their relations, as well as p/δy, are studied under ideal conditions, where δei/δy is equivalent stress of total stresses at elastoplastic juncture/yield strength, δei/δy is equivalent stress of total stresses at inside surface/yield strength, δei′/δy is equivalent stress of residual stresses at elastoplastic juncture/yield strength, δei′/δy is equivalent stress of residual stresses at inside surface/yield strength, p/δy is load-bearing capacity of an autofrettaged cylinder/yield strength. Theoretical study on the parameters results in noticeable results and laws. The main idea is: to satisfy |δei′|=δy, the relation between kj and k is , where k is outside/inside radius ratio of a cylinder, kj is ratio of elastoplastic juncture radius to inside radius of a cylinder; when the plastic region covers the whole wall of a cylinder, for compressive yield not to occur after removing autofrettage pressure, the ultimate k is k=2.218 46, with k=2.218 46, a cylinder's ultimate load-bearing capacity equals its entire yield pressure, or =lnk; when kj≤=1.648 72, no matter how great k is, compressive yield never occurs after removing pa; the maximum and optimum load-bearing capacity of an autofrettaged cylinder is just two times the loading which an unautofrettaged cylinder can bear elastically, or , thus the limit of the load-bearing capacity of an autofrettaged cylinder is also just 2 times that of an unautofrettaged cylinder.

  7. Cultural Difference of Paralanguage Use between Chinese and American TV Talk Show Hosts

    Institute of Scientific and Technical Information of China (English)

    刘君红

    2014-01-01

    Study of cultural difference of paralanguage use between Chinese and American TV talk show hosts is important for in⁃tercultural communication. The result shows that American TV talk show host uses more paralanguage signals than her Chinese counterpart. And American host uses more types of paralanguage signals than her Chinese counterpart. The difference of paralangue use indicates the cultural difference between China and America on the values of equality vs. hierarchy and individual⁃ism vs. collectivism. The study is significant in that it helps us to understand the hidden cultural values in TV talk shows and pro⁃motes nonverbal communication.

  8. Testbeam Results of Endcap RPC's

    CERN Document Server

    Ahmed, Ijaz; Hoorani, Hafeez; Aftab, Zia; Jan, J. A; Shariq Khan, M; Solaija, Tariq

    2006-01-01

    In this paper, results are presented from the beamtest in 2002 of the full-scale RE-2/2 prototype RPC chamber assembled in Pakistan. The results are mainly related with the efficiency, time resolution, and rate capability of this non-oiled RPC. The CMS collaboration has imposed strict criteria on the performance parameters for RPC's. These results show that prototype RPC's meet with all the CMS criteria and are suitable for installation in CMS detector.

  9. Resultative Predicates in Japanese

    Directory of Open Access Journals (Sweden)

    Kaori Takamine

    2007-12-01

    Full Text Available Washio (1997; 1999 observes that resultative predicates are divided into two different groups, strong and weak resultatives, depending on ‘patienthood’ of the object. This typology of resultatives seems to capture a point of crosslinguistic variation in resultatives; Japanese has weak but not strong resultatives, while English has both. Washio also observes that there is another group of examples that bears a superficial resemblance to resultatives but constitutes a different phenomenon, hence spurious resultatives. The difference between weak and strong resultatives is made in terms of the ‘affectedness’ of the verb. Thus the typology of resultatives proposed by Washio is semantically grounded. In this paper, I propose: (i a fine-grained distinction for Washio’s weak resultatives: (ii a syntactic analysis of the different resultative types. On the basis of syntactic evidence, I argue that there are two types of weak resultatives, an adjunct of VP and a complement of VP within the vP projection. I also argue that spurious resultatives are structurally higher than weak resultatives in Japanese.

  10. Impact Toughness of an Isothermally Treated Zeron®100 SDSS

    Science.gov (United States)

    Calliari, Irene; Breda, Marco; Ramous, Emilio; Brunelli, Katya; Pizzo, Marco; Menapace, Cinzia

    2012-10-01

    The aim of the present study is to investigate the impact toughness of a UNS 32760 SDSS, in relation to the quantity of secondary phases precipitated after isothermal aging in the range of 850-950 °C and for different exposure times. The impact toughness has been investigated by means of instrumented impact testing, using Charpy V-notched specimens at room temperature. The impact testing results show that, for an amount of about 0.5% volume fraction of intermetallic phase, the impact toughness is reduced by over 50%. For volume fractions higher than 1.5-2%, the impact toughness is definitively compromised, and small entities of plastic deformations are enough to cause a prevailing brittle fracture mechanism. By increasing the precipitates' amounts, the fracture mechanism shows an ever more prominent brittle behavior until 6% volume fraction, exceeding which the ductile component is totally absent.

  11. Complexity Results in Epistemic Planning

    DEFF Research Database (Denmark)

    Bolander, Thomas; Jensen, Martin Holm; Schwarzentruber, Francois

    2015-01-01

    Epistemic planning is a very expressive framework that extends automated planning by the incorporation of dynamic epistemic logic (DEL). We provide complexity results on the plan existence problem for multi-agent planning tasks, focusing on purely epistemic actions with propositional preconditions....... We show that moving from epistemic preconditions to propositional preconditions makes it decidable, more precisely in EXPSPACE. The plan existence problem is PSPACE-complete when the underlying graphs are trees and NP-complete when they are chains (including singletons). We also show PSPACE......-hardness of the plan verification problem, which strengthens previous results on the complexity of DEL model checking....

  12. Comportamento agressivo em shows musicais: analisando notícias de jornal impresso

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Pimentel

    2011-08-01

    Full Text Available This paper reports a content analysis of the newspaper articles dealing with aggressive behavior in music shows. This analysis permits an understanding of the characteristics of these situations, the aggressive behaviors in shows, and the way in which the print media treat the subject. Despite of the newspapers’ influence on public opinion formation, that is, the transmission of attitudes and behavior repertoires, this kind of analysis is rarely reported in Brazilian social psychological literature. Some 31 newspaper articles were content analyzed as to aggressive behavior during music shows. Results indicate that aggressive behaviors occur in shows of most varied musical styles. Results are discussed on the basis of social cognitive theory.

  13. Total 2004 results

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-02-01

    This document presents the 2004 results of Total Group: consolidated account, special items, number of shares, market environment, adjustment for amortization of Sanofi-Aventis merger-related intangibles, 4. quarter 2004 results (operating and net incomes, cash flow), upstream (results, production, reserves, recent highlights), downstream (results, refinery throughput, recent highlights), chemicals (results, recent highlights), Total's full year 2004 results (operating and net income, cash flow), 2005 sensitivities, Total SA parent company accounts and proposed dividend, adoption of IFRS accounting, summary and outlook, main operating information by segment for the 4. quarter and full year 2004: upstream (combined liquids and gas production by region, liquids production by region, gas production by region), downstream (refined product sales by region, chemicals), Total financial statements: consolidated statement of income, consolidated balance sheet (assets, liabilities and shareholder's equity), consolidated statements of cash flows, business segments information. (J.S.)

  14. Overview of ALICE results

    CERN Document Server

    Ortiz, Antonio

    2015-01-01

    The ALICE detector was designed to study the physics of matter under extreme conditions of high energy density. Different results were reported by the experiment using data from the successful run I of the LHC. The goal of the present work is to present an overview of recent ALICE results. This comprises selected results from several analyses of pp, p-pb and Pb-Pb data at the LHC energies.

  15. The Arising of Results

    DEFF Research Database (Denmark)

    Sobisch, Jan-Ulrich

    2013-01-01

    Some Buddhist scholars have periodized the expected lifetime of the Buddha's teachings. According to them, these periods of 500 years each have different characteristics. The first is called 'the period of the results'. Therefore some scholars have claimed that only in the first 500 years after...... the Buddha results can arise. Kyobpa Jigten Sumgön has argued that results arise through practise as long as Dharma and Sangha exist....

  16. Unfavorable results in replantation

    OpenAIRE

    Abraham G Thomas

    2013-01-01

    Reattachment of amputated parts of the body (Replantation) has become a reality since the first arm replant was carried out six decades ago. Failures were not uncommon in the beginning, leading on to the analysis of the problem and refinements in technique. Improvements in sutures, instrumentation and better microscopes further helped the surgeons to do replantation with better finesse and functional results. Evaluation of results and particularly failure and long term results help the younge...

  17. What Makes the Difference? Pop Music Stars and TV Talent Show Contestants in Adolescents' Judgements

    OpenAIRE

    Lothwesen, Kai; Müllensiefen, Daniel

    2005-01-01

    This paper summarises the approach, empirical methodologies, and part of the results of an empirical study that was conducted in early 2004, when musical TV talent shows reached their peak popularity among young media\\ud audiences in Germany. Our primary research interest was in the similarities and differences that the adolescent\\ud target group of this TV format might perceive between contestants in TV talent shows and real or ordinary pop\\ud music stars. Shows in this TV format all seem to...

  18. Assessing the Effect of a Digital Planetarium Show on the Astronomical Understanding of Fifth Graders

    Science.gov (United States)

    Larsen, K.; Bednarski, M.

    2011-09-01

    Although one-time planetarium shows have been popular field trips for elementary school classes over the past few decades, research on the effectiveness of these shows in increasing student understanding of astronomical concepts is spotty and mixed. There is even less research on the efficacy of new digital full-dome planetarium technology. This talk discusses the results of a study done with fifth grade students to test the relative efficacy of hands-on 3-D models and a digital full-dome planetarium show in teaching the sun-earth-moon system.

  19. New results from COMPASS

    CERN Document Server

    Kabuß, Eva-Maria

    2015-01-01

    An overview on recent COMPASS results is given, including the extraction of the longitudinal spin structure functions interpreted with a NLO QCD fit, new results on the gluon polarisation and a measurement of pion and kaon multiplicities with a LO extraction of quark-to-hadron fragmentation functions

  20. Duration and Results (PECODR

    Directory of Open Access Journals (Sweden)

    Martin Dawes

    2007-01-01

    Conclusions Results suggest a PECODR-related structure exists in medical abstracts and that there might be lexical patterns specific to these elements. More sophisticated computer-assisted lexical-semantic analysis might refine these results, and pave the way to automating PECODR indexing, and improve information retrieval in primary care.

  1. Recent results from TRISTAN

    Energy Technology Data Exchange (ETDEWEB)

    Enomoto, Ryoji [National Laboratory for High Energy Physics, Ibaraki (Japan)

    1997-01-01

    TRISTAN results on {gamma}{gamma} physics from 1994 to 1995 are reviewed in this report. We have systematically investigated jet production, the {gamma}-structure function, and charm pair production in {gamma}{gamma} processes. The results are discussed, and future prospects are presented.

  2. Verification of the effect of surface preparation on Hot Isostatic Pressing diffusion bonding joints of CLAM steel

    Science.gov (United States)

    Zhao, Yanyun; Li, Chunjing; Huang, Bo; Liu, Shaojun; Huang, Qunying

    2014-12-01

    Hot Isostatic Pressing (HIP) diffusion bonding with CLAM steel is the primary candidate fabrication technique for the first wall (FW) of DFLL-TBM. Surface state is one of the key factors for the joints quality. The effect of surface state prepared with grinder and miller on HIP diffusion bonding joints of CLAM steel was investigated. HIP diffusion bonding was performed at 140 MPa and 1373 K within 3 h. The mechanical properties of the joints were investigated with instrumented Charpy V-notch impact tests and the microstructures of the joints were analyzed with scanning electron microscopy (SEM). The results showed that the milled samples with fine surface roughness were more suitable for CLAM steel HIP diffusion bonding.

  3. Degradation of impact fracture during accelerated aging of weld metal on microalloyed steel; Degradacion de la tenacidad al impacto durante el envejecimiento acelerado de soldadura en acero microaleado

    Energy Technology Data Exchange (ETDEWEB)

    Vargas-Arista, B.; Hallen, J. M.; Albiter, A.; Angeles-Chavez, C.

    2008-07-01

    The effect of accelerated aging on the toughness and fracture of the longitudinal weld metal on an API5L-X52 line pipe steel was evaluated by Charpy V-notch impact test, fracture analysis and transmission electron microscopy. Aging was performed at 250 degree centigrade for 100 to 1000 h. The impact results indicated a significant reduction in the fracture energy and impact toughness as a function of aging time, which were achieved by the scanning electron microscope fractography that showed a decrease in the vol fraction of microvoids by Charpy ductile failure with the aging time, which favored the brittle fracture by transgranular cleavage. The minimum vol fraction of microvoids was reached at 500 h due to the peak aged. The microstructural analysis indicated the precipitation of transgranular iron nano carbides in the aged specimens, which was related to the deterioration of toughness and change in the ductile to brittle behavior. (Author) 15 refs.

  4. The Effect of Constant and Pulsed Current Gas Tungsten Arc Welding on Joint Properties of 2205 Duplex Stainless Steel to 316L Austenitic Stainless Steel

    Science.gov (United States)

    Neissi, R.; Shamanian, M.; Hajihashemi, M.

    2016-05-01

    In this study, dissimilar 316L austenitic stainless steel/2205 duplex stainless steel (DSS) joints were fabricated by constant and pulsed current gas tungsten arc welding process using ER2209 DSS as a filler metal. Microstructures and joint properties were characterized using optical and electron scanning microscopy, tensile, Charpy V-notch impact and micro-hardness tests, and cyclic polarization measurements. Microstructural observations confirmed the presence of chromium nitride and delta ferrite in the heat-affected zone of DSS and 316L, respectively. In addition, there was some deviation in the austenite/ferrite ratio of the surface welding pass in comparison to the root welding pass. Besides having lower pitting potential, welded joints produced by constant current gas tungsten arc welding process, consisted of some brittle sigma phase precipitates, which resulted in some impact energy reduction. The tensile tests showed high tensile strength for the weld joints in which all the specimens were broken in 316L base metal.

  5. Verification of the effect of surface preparation on Hot Isostatic Pressing diffusion bonding joints of CLAM steel

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Yanyun [University of Science and Technology of China, Hefei, Anhui 230027 (China); Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Li, Chunjing, E-mail: chunjing.li@fds.org.cn [Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Huang, Bo; Liu, Shaojun [Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China); Huang, Qunying [University of Science and Technology of China, Hefei, Anhui 230027 (China); Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031 (China)

    2014-12-15

    Hot Isostatic Pressing (HIP) diffusion bonding with CLAM steel is the primary candidate fabrication technique for the first wall (FW) of DFLL-TBM. Surface state is one of the key factors for the joints quality. The effect of surface state prepared with grinder and miller on HIP diffusion bonding joints of CLAM steel was investigated. HIP diffusion bonding was performed at 140 MPa and 1373 K within 3 h. The mechanical properties of the joints were investigated with instrumented Charpy V-notch impact tests and the microstructures of the joints were analyzed with scanning electron microscopy (SEM). The results showed that the milled samples with fine surface roughness were more suitable for CLAM steel HIP diffusion bonding.

  6. Ibis DDT test results

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document contains test results from a study done to determine the organochlorine levels in the livers of white-faced ibis from Stillwater Wildlife Management...

  7. Transacsys PLC - Final Results

    CERN Multimedia

    2002-01-01

    Final results from Transacsys PLC. A subsidary of this company was set up to develop the CERN EDH system into a commercial product but incurred too much financial loss so the project was cancelled (1/2 page).

  8. Microenterprise Results Reporting

    Data.gov (United States)

    US Agency for International Development — Microenterprise Results Reporting (MRR) is an annual report to the U.S. Congress providing funding and program data on USAID's microenterprise activities. The MRR...

  9. Haiti DevResults

    Data.gov (United States)

    US Agency for International Development — DevResults is a web-based portfolio management system that tracks program data for the Haiti Mission that was awarded in April of 2013. (The Mozambique and/or...

  10. Higgs results from ATLAS

    Directory of Open Access Journals (Sweden)

    Chen Xin

    2016-01-01

    Full Text Available The updated Higgs measurements in various search channels with ATLAS Run 1 data are reviewed. Both the Standard Model (SM Higgs results, such as H → γγ, ZZ, WW, ττ, μμ, bb̄, and Beyond Standard Model (BSM results, such as the charged Higgs, Higgs invisible decay and tensor couplings, are summarized. Prospects for future Higgs searches are briefly discussed.

  11. ATLAS physics results

    CERN Document Server

    AUTHOR|(CDS)2074312

    2015-01-01

    The ATLAS experiment at the Large Hadron Collider at CERN has been successfully taking data since the end of 2009 in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV, and in heavy ion collisions. In these lectures, some of the most recent ATLAS results will be given on Standard Model measurements, the discovery of the Higgs boson, searches for supersymmetry and exotics and on heavy-ion results.

  12. Unfavorable results in replantation

    Directory of Open Access Journals (Sweden)

    Abraham G Thomas

    2013-01-01

    Full Text Available Reattachment of amputated parts of the body (Replantation has become a reality since the first arm replant was carried out six decades ago. Failures were not uncommon in the beginning, leading on to the analysis of the problem and refinements in technique. Improvements in sutures, instrumentation and better microscopes further helped the surgeons to do replantation with better finesse and functional results. Evaluation of results and particularly failure and long term results help the younger surgeons to learn from the difficulties faced earlier to do better in the future. An attempt is made to list various aspects of replantation experienced by the author during the past 30 years, particularly in reference to unfavorable results, which had been occasionally total failure, or a partial failure, with poor function and cosmesis due to infection. An insensate limb with poor function is the result of inadequate or improper nerve coaptation or infection destroying the whole repair. It is apt to mention that infection is mostly the result of poor vascularity due to devitalized tissue. Difficulties arise often in identifying the viable tissue, particularly while debriding in the distal amputated part since there is no bleeding. Experience counts in this, specifically to identify the viable muscle. The factors that may lead to complications are listed with remarks to avoid them.

  13. Unfavorable results in replantation.

    Science.gov (United States)

    Thomas, Abraham G

    2013-05-01

    Reattachment of amputated parts of the body (Replantation) has become a reality since the first arm replant was carried out six decades ago. Failures were not uncommon in the beginning, leading on to the analysis of the problem and refinements in technique. Improvements in sutures, instrumentation and better microscopes further helped the surgeons to do replantation with better finesse and functional results. Evaluation of results and particularly failure and long term results help the younger surgeons to learn from the difficulties faced earlier to do better in the future. An attempt is made to list various aspects of replantation experienced by the author during the past 30 years, particularly in reference to unfavorable results, which had been occasionally total failure, or a partial failure, with poor function and cosmesis due to infection. An insensate limb with poor function is the result of inadequate or improper nerve coaptation or infection destroying the whole repair. It is apt to mention that infection is mostly the result of poor vascularity due to devitalized tissue. Difficulties arise often in identifying the viable tissue, particularly while debriding in the distal amputated part since there is no bleeding. Experience counts in this, specifically to identify the viable muscle. The factors that may lead to complications are listed with remarks to avoid them.

  14. Customer interruption cost and results

    Energy Technology Data Exchange (ETDEWEB)

    Eua-Arporn, B.; Bisarnbutra, S. [Chulalongkorn Univ., Bangkok (Thailand)

    1997-12-31

    Results of a comprehensive study on short-term direct impacts and consumer interruption costs, incurred as a result of power supply interruption, were discussed. The emphasis was on questionnaire development, general responses and the average customer damage function of some selected sectors. The customer damage function was established for each category of customers (agriculture, industry, mining, wholesale, retail merchandising, residential, etc) as well as for different locations. Results showed that the average customer damage function depended mostly on customer category. Size and location were not significant factors. 5 refs., 7 tabs.

  15. Consumer behavior towards show-room services of two wheelers with reference to Cuddalore district

    Directory of Open Access Journals (Sweden)

    S.Pragadeeswaran

    2009-12-01

    Full Text Available The study aims to find out the consumer behavior towards showroom service of two wheelers. A samples of 200 users selected randomly were studied. Standardized questionnaires were used to collect the data. The results reveal that users differ in consumer behaviour towards showroom services of two wheelers on the basis of satisfied random sampling. This study is made to describe the consumer satisfaction of two wheelers with respect to socio-economic characteristics as age, gender, occupation, family income, educational level and so on which is called descriptive study. The data were treated statistically using t-test, F-test and correlation. The result shows that students and employees are more satisfied about show room services. Demographic variables such as marital status, size of the family give significant effect related to show room services.

  16. 45 CFR 1302.20 - Grantee to show both legal status and financial viability.

    Science.gov (United States)

    2010-10-01

    ... viability. 1302.20 Section 1302.20 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE... both legal status and financial viability. (a) Upon the occurrence of a change in the legal condition... viability. Failure to make this showing may result in suspension, termination or denial of refunding....

  17. Soya bean tempe extracts show antibacterial activity against Bacillus cereus cells and spores

    NARCIS (Netherlands)

    Roubos-van den Hil, P.J.; Dalmas, E.; Nout, M.J.R.; Abee, T.

    2010-01-01

    Aims: Tempe, a Rhizopus ssp.-fermented soya bean food product, was investigated for bacteriostatic and/or bactericidal effects against cells and spores of the food-borne pathogen Bacillus cereus. Methods and results: Tempe extract showed a high antibacterial activity against B. cereus ATCC 14579 bas

  18. Genetic connections between dressage and show-jumping horses in Dutch Warmblood horses

    NARCIS (Netherlands)

    Rovere, G.A.; Madsen, O.; Norberg, E.; Arendonk, van J.A.M.; Ducro, B.J.

    2014-01-01

    During the last decades, the breeding practice within the Dutch Warmblood studbook (KWPN) has resulted in an increasing specialisation of horses into show-jumping (JH) and dressage (DH). The objective of this study was to describe the effect of the specialisation on the connectedness between the sub

  19. Suffering by comparison: Twitter users' reactions to the Victoria's Secret Fashion Show.

    Science.gov (United States)

    Chrisler, Joan C; Fung, Kaitlin T; Lopez, Alexandra M; Gorman, Jennifer A

    2013-09-01

    Social comparison theory suggests that evaluating the self in comparison with others (e.g., peers, celebrities, models) can influence body image. Experimental studies that have tested effects of viewing idealized images in the media often show that women feel worse about themselves after seeing images that illustrate the beauty ideal. Twitter presents a naturally occurring opportunity to study viewers' reactions. An analysis was conducted of 977 tweets sent immediately before and during the 2011 Victoria's Secret Fashion Show that reference the show. Although the majority were idiosyncratic remarks, many tweets contain evidence of upward social comparisons to the fashion models. There were tweets about body image, eating disorders, weight, desires for food or alcohol, and thoughts about self-harm. The results support social comparison theory, and suggest that vulnerable viewers could experience negative affect, or even engage in harmful behaviors, during or after viewing the show or others like it.

  20. New Results from Chandra

    CERN Document Server

    Forman, W; Jones, C; Vikhlinin, A A; Churazov, E

    2001-01-01

    We discuss two themes from Chandra observations of galaxies and clusters. First, we describe the effects of radio-emitting plasmas or ``bubbles'', inflated by active galactic nuclei, on the hot X-ray emitting gaseous atmospheres in galaxies and clusters. We describe the interaction of the ``bubbles'' and the X-ray emitting gas as the buoyant bubbles rise through the hot gas. Second, we describe sharp, edge-like surface brightness structures in clusters. Chandra observations show that these features are not shock fronts as was originally thought, but ``cold fronts'', most likely the boundaries of the remaining cores of merger components. Finally, we present recent observations of M86 and NGC507 which show similar sharp features around galaxies. For M86, the sharp edge is the boundary between the galaxy's X-ray corona and the Virgo cluster gas. The structures around NGC507, the central galaxy in a group, could be relics of galaxy formation or may reflect the motion of NGC507 in the larger potential of the group...

  1. Scientific results from COBE

    Science.gov (United States)

    Bennett, C. L.; Boggess, N. W.; Cheng, E. S.; Hauser, M. G.; Kelsall, T.; Mather, J. C.; Moseley, S. H., Jr.; Murdock, T. L.; Shafer, R. A.; Silverberg, R. F.

    1993-01-01

    NASA's Cosmic Background Explorer (COBE) carries three scientific instruments to make precise measurements of the spectrum and anisotropy of the cosmic microwave background (CMB) radiation on angular scales greater than 7 deg and to conduct a search for a diffuse cosmic infrared background (CIB) radiation with 0.7 deg angular resolution. Data from the Far-Infrared Absolute Spectrophotometer (FIRAS) show that the spectrum of the CMB is that of a blackbody of temperature T = 2.73 +/- 0.06 K, with no deviation from a blackbody spectrum greater than 0.25% of the peak brightness. The first year of data from the Differential Microwave Radiometers (DMR) show statistically significant CMB anisotropy. The anisotropy is consistent with a scale invariant primordial density fluctuation spectrum. Infrared sky brightness measurements from the Diffuse Infrared Background Experiment (DIRBE) provide new conservative upper limits to the CIB. Extensive modeling of solar system and galactic infrared foregrounds is required for further improvement in the CIB limits.

  2. Review of LEP results

    CERN Document Server

    Parodi, F

    2001-01-01

    I present a review of the results obtained during 10 years of activity in b-physics at LEP. Special emphasis is put on measurements that attained precisions not even envisaged at the beginning of the LEP programme (V/sub ub/ and Delta m/sub s/). Finally the impact of these measurements on the CKM parameters determination is presented. (16 refs).

  3. Results of CPLEAR

    Energy Technology Data Exchange (ETDEWEB)

    Rickenbach, R. [Basel Univ. (Switzerland); Adler, R. [Basel Univ. (Switzerland); Alhalel, T.; Angelopoulos, A.; Apostolakis, A.; Aslanides, E.; Backenstoss, G.; Bargassa, P.; Bee, C.P.; Behnke, O.; Benelli, A.; Bertin, V.; Blanc, F.; Bloch, P.; Carlson, P.; Carroll, M.; Carvalho, J.; Cawley, E.; Charalambous, S.; Chardin, G.; Chertok, M.B.; Cody, A.; Danielsson, M.; Dejardin, M.; Derre, J.; Ealet, A.; Eckart, B.; Eleftheriadis, C.; Evangelou, I.; Faravel, L.; Fassnacht, P.; Felder, C.; Ferreira-Marques, R.; Fetscher, W.; Fidecaro, M.; Filipcic, A.; Francis, D.; Fry, J.; Gabathuler, E.; Gamet, R.; Garreta, D.; Gerber, H.-J.; Go, A.; Guyot, C.; Haselden, A.; Hayman, P.J.; Henry-Couannier, F.; Hollander, R.W.; Hubert, E.; Jon-And, K.; Kettle, P.-R.; Kochowski, C.; Kokkas, P.; Kreuger, R.; Le Gac, R.; Leimgruber, F.; Liolios, A.; Machado, E.; Mandic, I.; Manthos, N.; Marel, G.; Mikuz, M.; Miller, J.; Montanet, F.; Nakada, T.; Pagels, B.; Papadopoulos, I.; Pavlopoulos, P.; Pinto da Cunha, J.; Policarpo, A.; Polivka, G.; Roberts, B.L.; Ruf, T.; Sakeliou, L.; Sanders, P.; Santoni, C.; Schaefer, M.; Schaller, L.A.; Schietinger, T.; Schopper, A.; Schune, P.; Soares, A.; Tauscher, L.; Thibault, C.; Touchard, F.; Touramanis, C.; Triantis, F.; Van Beveren, E.; Van Eijk, C.W.E.; Vlachos, S.; Weber, P.; Wigger, O.; Wolter, M.; Yeche, C.; Zavrtanik, D.; Zimmerman, D.; CPLEAR Collaboration

    1997-06-01

    The CPLEAR experiment uses tagged K{sup 0} and K{sup 0} produced in pp annihilation at rest to measure CP-, T- and CPT-violation parameters in the neutral kaon system. The results of these measurements and some implications are reported. (orig.).

  4. Recent results from INDRA

    Directory of Open Access Journals (Sweden)

    Chbihi A.

    2015-01-01

    Full Text Available Recent results of the INDRA collaboration are presented in this contribution. They concern the evolution of reaction dynamics from the first stage of the collision to the production of fragments. Different probes are used to evidence the stopping/transparency, collective flow and the symmetry energy term of the nuclear equation of state.

  5. Results from ARGUS

    Science.gov (United States)

    Darden, C.

    1984-10-01

    The ARGUS collaboration reports results bearing on the fragmentation function for D*± mesons, the mass of the F± meson, the decays F±→φπ± and F±→φπ+π-π±, the decay γ'→π+π-γ and the radiative decay γ'→γΥ(3Pj).

  6. Recent CMS Results

    Directory of Open Access Journals (Sweden)

    Dorigo Tommaso

    2014-04-01

    Full Text Available The CMS experiment obtained a large number of groundbreaking results from the analysis of 7- and 8-TeV proton-proton collisions produced so far by the Large Hadron Collider at CERN. In this brief summary only a few of those results will be discussed. The new scalar discovered in 2012 has been studied in detail and all its characteristics have been found in agreement with standard model predictions for a Brout-Englert-Higgs boson. The large sample of top quark events collected in 2011 and 2012 have allowed world-class measurements of its mass; the combination of those results is Mt = 173.49 ± 0.36 ± 0.91 GeV. The rare decay Bs0 → μμ has been observed and found in agreement with standard model predictions; the search for the rare decay B0 → μμ has allowed to set a 95% CL limit on the branching fraction at 1.1 × 10−9. These two results strongly constrain new physics models.

  7. NIH Research to Results

    Science.gov (United States)

    ... on. The National Institute of Neurological Disorders and Stroke (NINDS) is researching treatments that can be given in the first hours after a TBI to prevent or reverse much of the brain damage resulting from the injury. A recently completed NINDS– ...

  8. Roadmap of Infinite Results

    DEFF Research Database (Denmark)

    Srba, Jiří

    2002-01-01

    This paper provides a comprehensive summary of equivalence checking results for infinite-state systems. References to the relevant papers will be updated continuously according to the development in the area. The most recent version of this document is available from the web-page http://www.brics.dk/~srba/roadmap....

  9. Top Quark Results

    CERN Document Server

    ATLAS collaboration; LHCb collaboration

    2016-01-01

    Measurements of top quarks from Run-I and Run-II of the LHC are presented. Results on differential and inclusive top quark production cross sections, measured by the ATLAS, CMS and LHCb experiments, and measurements of top quark properties and mass are reported.

  10. CPT Results from Ktev

    Science.gov (United States)

    Nguyen, Hogan

    2002-02-01

    We present several preliminary measurements from KTeVREFID="9789812778123_0014FN001"> of the fundamental neutral K parameters, and their implications for CPT violation. A new limit is given on the sidereal time dependence of φ+-. The results are based on data collected in 1996-97.

  11. Recent results from MAC

    Energy Technology Data Exchange (ETDEWEB)

    MAC Collaboration

    1982-05-01

    Some preliminary results from the MAC detector at PEP are presented. These include measurements of the angular distribution of ..gamma gamma.., ..mu mu.. and tau tau final states, a determination of the tau lifetime, a measurement of R, and a presentation of the inclusive muon p/sub perpendicular/ distribution for hadronic events.

  12. Recent CDF results

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, Gervasio; /Cantabria Inst. of Phys.

    2007-11-01

    As of November of 2007, the CDF detector has recorded approximately 2.7 fb{sup -1} of data. This contribution describes some of the most recent and most relevant results from the CDF collaboration in all areas of its wide physics program, as well as some insights into the Tevatron reach for Higgs searches within the next few years.

  13. Final results from the $\

    CERN Document Server

    Vidal-Sitjes, G

    2001-01-01

    An updated analysis of the full NOMAD data corresponding to approx 1.35 x 10 sup 6 charged current interactions has been performed to search for neutrino oscillations through nu subtau appearance. This document updates the recently published results on the nu submu -> nu subtau and nu submu -> nu sub e oscillations search in NOMAD with a unified analysis of the hadronic channels.

  14. Final NOMAD results on $\

    CERN Document Server

    Astier, Pierre; Baldisseri, Alberto; Baldo-Ceolin, Massimilla; Banner, M; Bassompierre, Gabriel; Benslama, K; Besson, N; Bird, I; Blumenfeld, B; Bobisut, F; Bouchez, J; Boyd, S; Bueno, A G; Bunyatov, S A; Camilleri, L L; Cardini, A; Cattaneo, Paolo Walter; Cavasinni, V; Cervera-Villanueva, A; Chukanov, A; Collazuol, G; Conforto, G; Conta, C; Contalbrigo, M; Cousins, R D; Daniels, D C; Degaudenzi, H M; Del Prete, T; De Santo, A; Dignan, T; Di Lella, L; do Couto e Silva, E; Dumarchez, J; Ellis, M; Feldman, G J; Ferrari, R; Ferrère, D; Flaminio, Vincenzo; Fraternali, M; Gaillard, Jean-Marc; Gangler, E; Geiser, A; Geppert, D; Gibin, D; Gninenko, S N; Godley, A; Gómez-Cadenas, J J; Gosset, J; Gössling, C; Gouanère, M; Grant, A; Graziani, G; Guglielmi, A M; Hagner, C; Hernando, J; Hubbard, D B; Hurst, P; Hyett, N; Iacopini, E; Joseph, C L; Juget, F R; Kirsanov, M M; Klimov, O L; Kokkonen, J; Kovzelev, A; Krasnoperov, A V; Kustov, D V; Kuznetsov, V E; Lacaprara, S; Lachaud, C; Lakic, B; Lanza, A; La Rotonda, L; Laveder, M; Letessier-Selvon, A A; Lévy, J M; Linssen, Lucie; Ljubicic, A; Long, J; Lupi, A; Marchionni, A; Martelli, F; Méchain, X; Mendiburu, J P; Meyer, J P; Mezzetto, Mauro; Mishra, S R; Moorhead, G F; Naumov, D V; Nédélec, P; Nefedov, Yu A; Nguyen-Mau, C; Orestano, D; Pastore, F; Peak, L S; Pennacchio, E; Pessard, H; Petti, R; Placci, Alfredo; Polesello, G; Pollmann, D; Polyarush, A Yu; Popov, B; Poulsen, C; Rico, J; Riemann, P; Roda, C; Rubbia, André; Salvatore, F; Schahmaneche, K; Schmidt, B; Schmidt, T; Sconza, A; Sevior, M E; Sillou, D; Soler, F J P; Sozzi, G; Steele, D; Stiegler, U; Stipcevic, M; Stolarczyk, T; Tareb-Reyes, M; Taylor, G N; Tereshchenko, V V; Toropin, A N; Touchard, A M; Tovey, Stuart N; Tran, M T; Tsesmelis, E; Ulrichs, J; Vacavant, L; Valdata-Nappi, M; Valuev, V Yu; Vannucci, François; Varvell, K E; Veltri, M; Vercesi, V; Vidal-Sitjes, G; Vieira, J M; Vinogradova, T G; Weber, F V; Weisse, T; Wilson, F F; Winton, L J; Yabsley, B D; Zaccone, Henri; Zuber, K; Zuccon, P; Krasnoperov, A V

    2001-01-01

    Results from the nu_tau appearance search in a neutrino beam using the full NOMAD data sample are reported. A new analysis unifies all the hadronic tau decays, significantly improving the overall sensitivity of the experiment to oscillations. The "blind analysis" of all topologies yields no evidence for an oscillation signal. In the two-family oscillation scenario, this sets a 90% C.L. allowed region in the sin^2(2theta)-Delta m^2 plane which includes sin^2(2theta)nu_tau oscillation hypothesis results in sin^2(2theta)<1.5 x 10^{-2} at large Delta m^2 and Delta m^2 < 5.9 eV^2/c^4 at sin^2(2theta)=1. We also derive limits on effective couplings of the tau lepton to nu_mu or nu_e.

  15. CLEO Results B Decays

    CERN Document Server

    Cassel, David G

    2001-01-01

    Measurements of many Standard Model constants are clouded by uncertainties in nonperturbative QCD parameters that relate measurable quantities to the underlying parton-level processes. Generally these QCD parameters have been obtained from model calculations with large uncertainties that are difficult to quantify. The CLEO Collaboration has taken a major step towards reducing these uncertainties in determining the CKM matrix elements Vcb and Vub using new measurements of the branching fraction and photon energy spectrum of B -> s gamma decays. This report includes: the new CLEO measurements of B -> s gamma decays, Vcb, and Vub; the first results from CLEO III data -- studies of B -> K pi, pi pi, and K Kbar decays; mention of some other recent CLEO B decay results; and plans for operating CESR and CLEO in the charm threshold region.

  16. RESULTS OF SLICE MEASUREMENTS

    CERN Document Server

    Rudolph, J

    2011-01-01

    The linear accelerator ELBE delivers high-brightness electron bunches to multiple user stations, including two IR-FEL oscillators [1], [2]. In the framework of an upgrade program the current thermionic injector is being replaced by a SRF-photoinjector [3], [4]. The SRF injector promises higher beam quality, especially required for future experiments with high power laser radiation. During the commissioning phase, the SRF-injector was running in parallel to the thermionic gun. After installation of a injection beamline (dogleg), beam from the SRF-injector can now be injected into the ELBE linac. Detailed characterization of the electron beam quality delivered by the new electron injector includes vertical slice emittance measurements in addition to measurements of projected emittance values. This report gives an overview of the status of the project and summarizes first measurement results as well as results of simulations performed with measurement settings.

  17. Recent results from LEP

    Indian Academy of Sciences (India)

    A Gurtu

    2000-04-01

    Recent results from the LEP collider at CERN are presented: on the identification of +- → +- and the determination of the mass and width and limits on its anomalous couplings; the search for the Standard Model and non-minimal Higgs; search for SUSY and other new particles. Fits to all electroweak data leading to predictions of the Higgs mass within the Standard Model are presented.

  18. Recent BABAR Results

    CERN Document Server

    Eigen, Gerald

    2015-01-01

    We present herein the most recent BABAR results on direct CP asymmetry measurements in B -> Xs gamma, on partial branching fraction and CP asymmetry measurements in B -> Xs l+l-, on a search for B -> pi/eta l+l- decays, on a search for lepton number violation in B -> X-l+l'+ modes and a study of B-> omega omega and B-> omega phi decays.

  19. Recent QCD Results

    CERN Document Server

    Lincoln, Don

    2009-01-01

    The study of the inelastic scattering of hadrons has progressed in the last decade. With the availability of high-statistics data sets from HERA and the Tevatron, our understanding of high energy and high jet multiplicity events has become rather precise. In this Proceedings, I present an overview of recent jet-only results, as well as measurements of events which combine both jets and a W or Z boson.

  20. Overview of ATLAS results

    CERN Document Server

    Grabowska-Bold, Iwona; The ATLAS collaboration

    2016-01-01

    The ATLAS experiment at the Large Hadron Collider has undertaken a broad physics program to probe and characterize the hot nuclear matter created in relativistic lead-lead collisions. This talk presents recent results based on Run 2 data on production of jet, electroweak bosons and quarkonium, electromagnetic processes in ultra-peripheral collisions, and bulk particle collectivity from PbPb, pPb and pp collisions.

  1. Explaining embodied cognition results.

    Science.gov (United States)

    Lakoff, George

    2012-10-01

    From the late 1950s until 1975, cognition was understood mainly as disembodied symbol manipulation in cognitive psychology, linguistics, artificial intelligence, and the nascent field of Cognitive Science. The idea of embodied cognition entered the field of Cognitive Linguistics at its beginning in 1975. Since then, cognitive linguists, working with neuroscientists, computer scientists, and experimental psychologists, have been developing a neural theory of thought and language (NTTL). Central to NTTL are the following ideas: (a) we think with our brains, that is, thought is physical and is carried out by functional neural circuitry; (b) what makes thought meaningful are the ways those neural circuits are connected to the body and characterize embodied experience; (c) so-called abstract ideas are embodied in this way as well, as is language. Experimental results in embodied cognition are seen not only as confirming NTTL but also explained via NTTL, mostly via the neural theory of conceptual metaphor. Left behind more than three decades ago is the old idea that cognition uses the abstract manipulation of disembodied symbols that are meaningless in themselves but that somehow constitute internal "representations of external reality" without serious mediation by the body and brain. This article uniquely explains the connections between embodied cognition results since that time and results from cognitive linguistics, experimental psychology, computational modeling, and neuroscience.

  2. GIRAFFE test results summary

    Energy Technology Data Exchange (ETDEWEB)

    Yokobori, S.; Arai, K.; Oikawa, H. [Toshiba Corporation, Kawasaki (Japan)

    1996-03-01

    A passive system can provide engineered safety features enhancing safety system reliability and plant simplicity. Toshiba has conducted the test Program to demonstrate the feasibility of the SBWR passive safety system using a full-height, integral system test facility GIRAFFE. The test facility GIRAFFE models the SBWR in full height to correctly present the gravity driving head forces with a 1/400 volume scale. The GIRAFFE test Program includes the certification tests of the passive containment cooling system (PCCS) to remove the post-accident decay heat and the gravity driven cooling system (GDCS) to replenish the reactor coolant inventory during a LOCA. The test results have confirmed the PCCS and GDCS design and in addition, have demonstrated the operation of the pCCS with the presence of a lighter-than-steam noncondensable as well as with the presence of a heavier-than-steam, noncondensable. The GIRAFFE test Program has also provided the database to qualify a best estimate thermal-hydraulic computer code TRAC. The post test analysis results have shown that TRAC can accurately predict the PCCS heat removal Performance and the containment pressure response to a LOCA. This paper summarizes the GIRAFFE test results to investigate post-LOCA PCCS heat removal performance and post-test analysis using TRAC.

  3. Ageing research on vertebrates shows knowledge gaps and opportunities for species conservation and management

    DEFF Research Database (Denmark)

    Conde, Dalia Amor

    is constant when species reach maturity. The implications of these assumptions have strong consequences not only in the development of evolutionary theories of ageing and population ecology but also in species conservation. By modeling mortality of different species of vertebrates we show that different...... models are needed to explore the diversity of mortality trajectories in animals. However, our state of demographic knowledge even for vertebrates is by far deficient to incorporate the effects on age. Exploring 13 available datasets on vertebrate life histories traits, our results show surprising figures...

  4. Showing and telling: using tablet technology to engage students in mathematics

    Science.gov (United States)

    Ingram, Naomi; Williamson-Leadley, Sandra; Pratt, Keryn

    2016-03-01

    This paper reports on a qualitative investigation into the use of Show and Tell tablet technology in mathematics classrooms. A Show and Tell application (app) allows the user to capture voice and writing or text in real time. Described here are the perceptions of 11 teachers during and after their exploration into the use of Show and Tell in their primary and secondary classrooms. These perceptions were used to evaluate Show and Tell tablet technology against a framework of student engagement and effective pedagogy. The results of the study indicated that the teachers perceived both the level and the quality of the students' engagement were high. Using Show and Tell apps enabled the teachers to enact effective pedagogy within their classroom practices. Importantly, through the use of Show and Tell recordings, students' thinking became visible to themselves, their teachers and other students in the class. This thinking then formed the basis of robust discussions and negotiation about the mathematical concepts and the strategies the students used to solve problems.

  5. The Use of Online Pre-Lab Assessments Compared with Written Pre-Lab Assignments Requiring Experimental Result Prediction Shows No Difference in Student Performance

    OpenAIRE

    Suchman, Erica L

    2015-01-01

    Exam performance was compared for students who hand wrote questions designed to prepare them for daily lab activities in a senior level virology laboratory course versus those who answered questions created to mirror the written questions on-line.  No significant difference was noted in exam scores on any of the three midterms, written final exam, nor the practical exam.  Neither was there a significant difference in the quality of the laboratory reports turned in as evidenced by similar aver...

  6. Can Using Rigorous Evidence to Guide Federal Education Funds Improve Student Achievement? Randomized Trials Show Encouraging Initial Results for DoED's Investing in Innovation Fund

    Science.gov (United States)

    Coalition for Evidence-Based Policy, 2014

    2014-01-01

    An important recent development in evidence-based policy is the federal government's use of a "tiered evidence" approach to allocating funding in grant programs such as the U.S. Department of Education's Investing in Innovation Fund (i3). A central feature of this approach is that the largest grants are awarded to fund large-scale…

  7. Recent Results from SELEX

    CERN Document Server

    Russ, J

    2001-01-01

    The SELEX experiment (E781) is 3-stage magnetic spectrometer for the study of charm hadroproduction at large xF using 600 Gev Sigma-, pi- and p beams. New precise measurements of the Lambda_c, D0, and Ds lifetimes are presented. We also report results on Lambda_c and Ds production by Sigma-, pi- and p beams at xF>0.2. The data agree with expectations from color-drag models to explain charm particle/antiparticle production asymmetries.

  8. First LHC Results

    CERN Document Server

    Horn, Claus; The ATLAS collaboration

    2010-01-01

    Since four month the Large Hadron Collider (LHC) is producing proton-proton collisions with a center of mass energy of 7 TeV offering the potential of directly producing dark matter particles in an energy range never reached before in accelerator-based particle physics. First the performance and first Standard Model measurements of the general purpose experiments CMS and ATLAS is presented. This talk then focuses on their potential to detect dark matter candidates. Results from ongoing physics analyzes are presented and expectations for possible future discoveries are discussed.

  9. New results from CLEO

    CERN Document Server

    Dubrovin, M S; Huang, G S; Lee, J; Miller, D H; Pavlunin, V; Rangarajan, R; Sanghi, B; Shibata, E I; Shipsey, I P J; Cronin-Hennessy, D; Park, C S; Park, W; Thayer, J B; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R; Artuso, M; Boulahouache, C; Blusk, S; Dambasuren, E; Dorjkhaidav, O; Mountain, R; Muramatsu, H; Nandakumar, R; Skwarnicki, T; Stone, S; Wang, J C; Csorna, S E; Danko, I; Bonvicini, G; Cinabro, D; Dubrovin, M; McGee, S; Bornheim, A; Lipeles, E; Pappas, S P; Shapiro, A; Sun, W M; Weinstein, A J; Briere, R A; Chen, G P; Ferguson, T; Tatishvili, G T; Vogel, H; Watkins, M E; Adam, N E; Alexander, J P; Berkelman, K; Boisvert, V; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Galik, R S; Gibbons, L; Gittelman, B; Gray, S W; Hartill, D L; Heltsley, B K; Hsu, L; Jones, C D; Kandaswamy, J; Kreinick, D L; Magerkurth, A; Mahlke-Krüger, H; Meyer, T O; Mistry, N B; Patterson, J R; Peterson, D; Pivarski, J; Richichi, S J; Riley, D; Sadoff, A J; Schwarthoff, H; Shepherd, M R; Thayer, J G; Urner, D; Wilksen, T; Warburton, A; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Potlia, V; Stöck, H; Yelton, J; Benslama, K; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Lowrey, N; Plager, C; Sedlack, C; Selen, M; Thaler, J J; Williams, J; Edwards, K W; Besson, D; Anderson, S; Frolov, V V; Gong, D T; Kubota, Y; Li, S Z; Poling, R A; Smith, A; Stepaniak, C J; Urheim, J; Metreveli, Z V; Seth, K K; Tomaradze, A G; Zweber, P; Ahmed, S; Alam, M S; Ernst, J; Jian, L; Saleem, M; Wappler, F; Arms, K; Eckhart, E; Gan, K K; Gwon, C; Honscheid, K; Kagan, H; Kass, R; Pedlar, T K; Von Törne, E; Severini, H; Skubic, P L; Dytman, S A; Müller, J A; Nam, S; Savinov, V

    2005-01-01

    We present recent results from the CLEO Collaboration. The data used were collected from 1995 untill now at the Cornell Electron-positron Storage Ring (CESR). Measurements of the leptonic branching fractions for $\\psi(2S) \\to e^+ e^-, \\mu^+ \\mu^-$ and $\\Upsilon(1,2,3S) \\to \\mu^+ \\mu^-$, search for $D^0-\\bar{D^0}$ mixing using time dependent Dalitz plot analyses of the decay $D^0 \\to K^0_S\\pi^+\\pi^-$, and search for the process $e^+e^- \\to \\Lambda_b \\bar{\\Lambda_b}$ near threshold are discussed.

  10. Recent CDF results

    Energy Technology Data Exchange (ETDEWEB)

    Conway, J.S. [Rutgers--the State Univ., Piscataway, NJ (United States). Dept. of Physics and Astronomy; CDF Collaboration

    1996-07-01

    Preliminary results form the CDF detector, based on analysis of data collected in Run 1a and Run 1b at the Tevatron, totaling 110 pb{sup - 1} integrated luminosity, place new limits on the masses and couplings of new particles including charged Higgs bosons, supersymmetric gauge particles and quarks, and new vector bosons. One of the observed events, having an {ital e}{sup +}{ital e}{sup -} pair, two photons, and large missing energy would not occur with significant rate in the Standard Model, leading to speculation regarding its origin and the possible existence of related events.

  11. Overview of ATLAS results

    CERN Document Server

    Grabowska-Bold, Iwona; The ATLAS collaboration

    2016-01-01

    The heavy-ion programme in the ATLAS experiment at the Large Hadron Collider aims to probe and characterise hot and dense matter created in relativistic lead-lead collisions. Moreover, smaller collision systems involving nuclei and hadrons are of interest to disentangle initial- from final-state effects. This report presents new results based on lead-lead and proton-proton data collected at √sNN = 5.02 TeV in 2015, including measurements of bulk collectivity, charged-particle production, electroweak bosons, photon-jet correlations, and quarkonium suppression. First attempts to measure electromagnetic processes in ultra-peripheral collisions are also discussed.

  12. Latest LHCb results

    Directory of Open Access Journals (Sweden)

    Martinelli Maurizio

    2014-01-01

    Full Text Available The LHCb experiment is one of the major research projects at the Large Hadron Collider. Its acceptance and instrumentation is optimised to perform high-precision studies of flavour physics and particle production in a unique kinematic range at unprecedented collision energies. Using large data samples accumulated in the years 2010-2012, the LHCb collaboration has conducted a series of measurements providing a sensitive test of the Standard Model and strengthening our knowledge of flavour physics, QCD and electroweak processes. The status of the experiment and some of its recent results are presented here.

  13. Recent BABAR Results

    Energy Technology Data Exchange (ETDEWEB)

    Eigen, Gerald [University of Bergen, Bergen (Norway). Dept. of Physics

    2015-04-29

    We present herein the most recent BABAR results on direct CP asymmetry measurements in B → Xsγ, on partial branching fraction and CP asymmetry measurements in B → Xs+-, on a search for B → π/ηℓ+- decays, on a search for lepton number violation in B+ → X-+ℓ'+ modes and a study of B0 →ωω and B0 → ωφ decays.

  14. Results of railgun experiments

    Energy Technology Data Exchange (ETDEWEB)

    Hawke, R.S.; Brooks, A.L.; Fowler, C.M.; Peterson, D.R.

    1983-04-01

    During the 1979 Megagauss II conference the hypervelocity potential of railguns and the pulsed power technology needed to power them were discussed. Since then, many laboratories have initiated railgun R and D projects for a variety of potential applications. Los Alamos and Lawrence Livermore National Laboratories initiated a collaborative experimental railgun project which resulted in several successes in accelerating projectiles to high velocities, emphasized the limits on railgun operation, and indicated that the numerical modeling of railgun operation was in good agreement with the experiments.

  15. Recent results from CMS

    CERN Document Server

    Dordevic, Milos

    2016-01-01

    The highlights of the most recent CMS results with 13 TeV data will be presented in this overview. The Standard Model precision measurements, including the top quark production, will be shown first. This will be followed by the presentation of Higgs boson studies with the early 13 TeV data. Then the focus will shift to searches for physics beyond the Standard Model, including the searches for several Supersymmetric scenarios, using different analysis techniques. The talk will conclude with searches for the exotic resonances, with an emphasis on studies of the high-mass diphoton production.

  16. Results from AMANDA

    CERN Document Server

    Wiebusch, C; Bai, X; Barwick, S W; Becka, T; Becker, K H; Bertrand, D; Bernadini, E; Binon, Freddy G; Biron, A; Boser, S; Botner, O; Bouchta, A; Bouhali, O; Burgess, T; Carius, S; Castermans, T; Chen, A; Chirkin, D; Conrad, J; Cooley, J; Cowen, D F; Davour, A; De Clercq, C; De Young, T R; Desiati, P; Dewulf, J P; Doksus, P; Ekstrom, P; Feser, T; Gaisser, T K; Gaug, M; Gerhardt, L; Goldschmidt, A; Hallgren, A; Halzen, F; Hanson, K; Hardtke, R; Hauschildt, T; Hellwig, M; Herquet, P; Hill, G C; Hulth, P O; Hundertmark, S; Jacobsen, J; Karle, A; Koci, B; Köpke, L; Kowalski, M; Kühn, K; Lamoureux, J I; Leich, H; Leuthold, M J; Lindahl, P; Liubarsky, I; Madsen, J; Marciniewski, P; Matis, H S; McParland, C P; Minaeva, Y; Minocinovic, P; Mock, P C; Morse, R; Nahnhauer, R; Neunhoffer, T; Niessen, P; Nygren, D R; Ögelman, H B; Olbrechts, P; Pérez de los Heros, C; Pohl, A C; Price, P B; Przybylski, G T; Rawlins, K; Resconi, E; Rhode, W; Ribordy, M; Richter, S; Rodríguez-Martino, J; Ross, D; Sander, H G; Schmidt, T; Schneider, D; Schwarz, R; Silvestri, A; Solarz, M; Spiczak, G M; Spiering, C; Steele, D; Steffen, P; Stokstad, R G; Sudhoff, P; Sulanke, K H; Taboada, I; Thollander, L; Tilav, S; Walck, C; Weinheimer, C; Wiebusch, C; Wiedemann, C; Wischnewski, R; Wissing, H; Woschnagg, K; Yodh, G B; Young, S

    2002-01-01

    The Antarctic Muon and Neutrino Detector Array (AMANDA) is a high- energy neutrino telescope operating at the geographic South Pole. It is a lattice of photomultiplier tubes buried deep in the polar ice. The primary goal of this detector is to discover astrophysical sources of high energy neutrinos. We describe the detector methods of operation and present results from the AMANDA-B10 prototype. We demonstrate the improved sensitivity of the current AMANDA-II detector. We conclude with an outlook to the envisioned sensitivity of the future IceCube detector. (37 refs).

  17. Unfavourable results in pollicisation

    Directory of Open Access Journals (Sweden)

    Mukund R Thatte

    2013-01-01

    Full Text Available Pollicisation of the index finger is perhaps one of the most complex and most rewarding operations in hand and plastic surgery. It however has a steep learning curve and demands very high skill levels and experience. There are multiple pitfalls and each can result in an unfavourable result. In essence we need to: Shorten the Index, recreate the carpo metacarpal joint from the metacarpo phalangeal (MP joint, rotate the digit by about 120° for pulp to pulp pinch, palmarly abduct by 40-50° to get a new first web gap, Shorten and readjust the tension of the extensors, re attach the intrinsics to form a thenar eminence capable of positioning the new thumb in various functional positions and finally close the flaps forming a new skin envelope. The author has performed over 75 pollicisations personally and has personal experience of some of the issues raised there. The steps mentioned therefore are an algorithm for helping the uninitiated into these choppy waters.

  18. Maquet Osteotomy, Results

    Science.gov (United States)

    Díaz, Jorge Luis; Vega, Marcelo; Matesevach, Ivan

    2017-01-01

    Objectives: The objectives are to assess the results and to discuss the indications for Maquet osteotomy in patients with patellofemoral osteoarthritis. Methods: Retrospective study of a series of 32 patients (4 bilateral, that is to say, 36 knees) operated between March 1999 and October 2013 in " Arthroscopy Private Center ", 12 male and 20 female, average age 59 years with an average postoperative surgery outcomes of 53 months. The technique consists of an arthroscopic procedure to treat joint lesions and a tibial tuberosity osteotomy of 5 cm long, by embedding a 1cm subsequent graft taken from the same metaphysis and fixed with 2 screws. Results: All patients had significant improvement, evaluated with Kujala’s score (54 points preop to 86 points postop) and Guillamon Ferguson’s criteria (27.2 very good and 60.7 good). The complication rate was acceptable. Conclusion: The available technics are surgeries on proximal soft structures, osteotomies of tibial tuberosity and patellofemoral arthroplasty. Maquet osteotomy is an excellent procedure when the patient’s selection is right. Obtaining the graft from the same metaphysis simplified the procedure.

  19. Double Chooz: Latest results

    CERN Document Server

    Crespo-Anadón, J I

    2014-01-01

    The latest results from the Double Chooz experiment on the neutrino mixing angle $\\theta_{13}$ are presented. A detector located at an average distance of 1050 m from the two reactor cores of the Chooz nuclear power plant has accumulated a live time of 467.90 days, corresponding to an exposure of 66.5 GW-ton-year (reactor power $\\times$ detector mass $\\times$ live time). A revised analysis has boosted the signal efficiency and reduced the backgrounds and systematic uncertainties compared to previous publications, paving the way for the two detector phase. The measured $\\sin^2 2\\theta_{13} = 0.090^{+0.032}_{-0.029}$ is extracted from a fit to the energy spectrum. A deviation from the prediction above a visible energy of 4 MeV is found, being consistent with an unaccounted reactor flux effect, which does not affect the $\\theta_{13}$ result. A consistent value of $\\theta_{13}$ is measured in a rate-only fit to the number of observed candidates as a function of the reactor power, confirming the robustness of the ...

  20. Organic Separation Test Results

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Renee L.; Rinehart, Donald E.; Peterson, Reid A.

    2014-09-22

    Separable organics have been defined as “those organic compounds of very limited solubility in the bulk waste and that can form a separate liquid phase or layer” (Smalley and Nguyen 2013), and result from three main solvent extraction processes: U Plant Uranium Recovery Process, B Plant Waste Fractionation Process, and Plutonium Uranium Extraction (PUREX) Process. The primary organic solvents associated with tank solids are TBP, D2EHPA, and NPH. There is concern that, while this organic material is bound to the sludge particles as it is stored in the tanks, waste feed delivery activities, specifically transfer pump and mixer pump operations, could cause the organics to form a separated layer in the tank farms feed tank. Therefore, Washington River Protection Solutions (WRPS) is experimentally evaluating the potential of organic solvents separating from the tank solids (sludge) during waste feed delivery activities, specifically the waste mixing and transfer processes. Given the Hanford Tank Waste Treatment and Immobilization Plant (WTP) waste acceptance criteria per the Waste Feed Acceptance Criteria document (24590-WTP-RPT-MGT-11-014) that there is to be “no visible layer” of separable organics in the waste feed, this would result in the batch being unacceptable to transfer to WTP. This study is of particular importance to WRPS because of these WTP requirements.

  1. Recent Results from ARGUS

    Science.gov (United States)

    Schröder, Henning

    Using the ARGUS detector at the e+e- storage ring DORIS II at DESY new results on beauty and τ physics have been obtained. In particular, new measurements on fundamental constants in the Yukawa sector of the Standard Model are presented. These comprise measurements of CKM matrix elements from the study of B decays as well as determinations of properties of the τ lepton and its neutrino vτ. From semileptonic B decays ARGUS finds |Vcb|=0.050±0.008±0.007 and from B0 bar B0 mixing |Vtd|= 0.007±0.002. An analysis of the decay type τ-→π-π-π+ντ yields a τ mass of mτ=(1776.3±2.4±1.4) MeV/c2. This result also leads to an improvement of the upper limit on the m{ν r } < 31 {{{MeV}} {/ {{{MeV}} {{c}{2} }}} ; } {{c}{2} }} at the 95% confidence level.

  2. Emittance exchange results

    Energy Technology Data Exchange (ETDEWEB)

    Fliller, R.P., III; /Brookhaven; Koeth, T.; /Rutgers U., Piscataway

    2009-09-01

    The promise of next-generation light sources depends on the availability of ultra-low emittance electron sources. One method of producing low transverse emittance beams is to generate a low longitudinal emittance beam and exchange it with a large transverse emittance. Experiments are underway at Fermilab's A0 Photoinjector and ANL's Argonne Wakefield Accelerator using the exchange scheme of Kim and Sessler. The experiment at the A0 Photoinjector exchanges a large longitudinal emittance with a small transverse emittance. AWA expects to exchange a large transverse emittance with a small longitudinal emittance. In this paper we discuss recent results at A0 and AWA and future plans for these experiments.

  3. Emittance Exchange Results

    Energy Technology Data Exchange (ETDEWEB)

    Fliller III,R.; Koeth, T.

    2009-05-04

    The promise of next-generation light sources depends on the availability of ultra-low emittance electron sources. One method of producing low transverse emittance beams is to generate a low longitudinal emittance beam and exchange it with a large transverse emittance. Experiments are underway at Fermilab's A0 Photoinjector and ANL's Argonne Wakefield Accelerator using the exchange scheme of Kim and Sessler. The experiment at the A0 Photoinjector exchanges a large longitudinal emittance with a small transverse emittance. AWA expects to exchange a large transverse emittance with a small longitudinal emittance. In this paper we discuss recent results at A0 and AWA and future plans for these experiments.

  4. Iron Mountain Electromagnetic Results

    Energy Technology Data Exchange (ETDEWEB)

    Gail Heath

    2012-07-01

    Iron Mountain Mine is located seventeen miles northwest of Redding, CA. After the completion of mining in early 1960s, the mine workings have been exposed to environmental elements which have resulted in degradation in water quality in the surrounding water sheds. In 1985, the EPA plugged ore stoops in many of the accessible mine drifts in an attempt to restrict water flow through the mine workings. During this process little data was gathered on the orientation of the stoops and construction of the plugs. During the last 25 years, plugs have begun to deteriorate and allow acidic waters from the upper workings to flow out of the mine. A team from Idaho National Laboratory (INL) performed geophysical surveys on a single mine drift and 3 concrete plugs. The project goal was to evaluate several geophysical methods to determine competence of the concrete plugs and orientation of the stopes.

  5. 2012 election results

    Science.gov (United States)

    Robinson, Robert; Tetzlaff, Doerthe

    2012-10-01

    On 4 October 2012, AGU members completed voting for the 2013-2014 leadership term. Union officers, Board members, section and focus group officers, and student and early career representatives to the Council were elected. All members who joined or renewed their membership by 1 July 2012 were eligible to vote in this year's leadership election. The vote was held electronically, and access to voting was provided to all eligible voters for a period of 31 days. The voting was conducted by Survey and Ballot Systems, Inc. (SBS). SBS, which offers election planning and management services, provided unique login credentials and other support services for eligible voters throughout the election. Voting results were certified by SBS on 8 October and by the AGU Tellers Committee on 9 October. The overall participation rate was 21.9%, an increase over previous AGU elections.

  6. Payment by Results

    Directory of Open Access Journals (Sweden)

    Brendan A. Rapple

    1994-01-01

    Full Text Available Today the public is demanding that it exercise more control over how tax dollars are spent in the educational sphere, with multitudes also canvassing that education become closely aligned to the marketplace's economic forces. In this paper I examine an historical precedent for such demands, i.e. the comprehensive 19th century system of accountability, "Payment by Results," which endured in English and Welsh elementary schools from 1862 until 1897. Particular emphasis is focused on the economic market-driven aspect of the system whereby every pupil was examined annually by an Inspector, the amount of the governmental grant being largely dependent on the answering. I argue that this was a narrow, restrictive system of educational accountability though one totally in keeping with the age's pervasive utilitarian belief in laissez-faire. I conclude by observing that this Victorian system might be suggestive to us today when calls for analogous schemes of educational accountability are shrill.

  7. Overview of HERMES results

    Directory of Open Access Journals (Sweden)

    Van Hulse Charlotte

    2016-01-01

    Full Text Available The HERMES experiment has collected a wealth of deep-inelastic scattering data using the 27.6 GeV polarized lepton beam at HERA and various pure gas targets, both unpolarized and polarized. This allowed for a series of diverse and unique measurements. Among them are measurements that provide information on the threedimensional structure of the nucleon, both in momentum space and in position space. Results of measurements of exclusive ω production on an unpolarized and transversely polarized nucleon target, sensitive to the distribution in transverse-position and longitudinalmomentum space, are discussed as well as the three-dimensional extraction of azimuthal asymmetries measured in semi-inclusive deep-inelastic scattering, sensitive to twist-2 and twist-3 distributions in three-dimensional momentum space.

  8. Latest results from ALICE

    CERN Document Server

    Scapparone, Eugenio

    2011-01-01

    In this paper selected results obtained by the ALICE experiment at the LHC will be presented. Data collected during the pp runs taken at sqrt(s)=0.9, 2.76 and 7 TeV and Pb-Pb runs at sqrt(s_NN)=2.76 TeV allowed interesting studies on the properties of the hadronic and nuclear matter: proton runs gave us the possibility to explore the ordinary matter at very high energy and up to very low pt, while Pb-Pb runs provided spectacular events where several thousands of particles produced in the interaction revealed how a very dense medium behaves, providing a deeper picture on the quark gluon plasma(QGP) chemical composition and dynamics.

  9. Recent results from CMS

    CERN Document Server

    CERN. Geneva

    2016-01-01

    With the increase in center-of-mass energy, a new energy frontier has been opened by the Large Hadron Collider. More than 25 fb^-1 of proton-proton collisions at sqrt(s)=13 TeV have been delivered to both ATLAS and CMS experiments during 2016. This enormous dataset can be used to test the Standard Model in a complete new regime with tremendous precision and it has the potential to unveil new physics or set strong bounds on it. In this talk some of the most recent results made public by the CMS Collaboration will be presented. The focus will mainly be on searches for physics beyond the Standard Model, with particular emphasis on searches for dark matter candidates.

  10. Recent results from ANTARES

    Directory of Open Access Journals (Sweden)

    Trovato Agata

    2015-01-01

    Full Text Available Operating 40 km off the coast of France since 2007, the ANTARES detector is the largest deep-sea neutrino telescope in the Northern Hemisphere with an instrumented volume of more than 0.01 cubic kilometers. It consists of an array of 885 photomultipliers detecting the Cherenkov light induced by charged leptons produced by neutrino interactions in and around the detector. The primary goal of ANTARES is to search for astrophysical neutrinos in the TeV–PeV range. This comprises generic searches for any diffuse cosmic neutrino flux as well as more specific searches for astrophysical galactic and extragalactic sources. The search program also includes multi-messenger analyses based on time and/or space coincidences with other cosmic probes. The ANTARES observatory is sensitive to a wide-range of other phenomena, from atmospheric neutrino oscillations to dark matter annihilation. In this contribution, recent results from the ANTARES neutrino telescope will be presented.

  11. Paddy plants inoculated with PGPR show better growth physiology and nutrient content under saline condition

    Directory of Open Access Journals (Sweden)

    Yachana Jha

    2013-09-01

    Full Text Available The possible role of plant growth-promoting rhizobacteria (PGPR to alleviate salt stress during plant growth has been studied on paddy rice (Oryza sativa L. 'GJ-17' under greenhouse conditions; the study included growth parameters, mineral concentration, and antioxidant enzyme level. Salinity reduced plant growth, but PGPR inoculation reduced its harmful effect up to 1% salinity. Plants inoculated with PGPR under saline conditions showed 16% higher germination, 8% higher survival, 27% higher dry weight, and 31% higher plant height. Similarly, PGPR inoculated plants showed increased concentrations of N(26%, P (16%, K (31%, and reduced concentrations of Na (71% and Ca (36% as compared to non-inoculated control plants under saline conditions. Plants inoculated with PGPR under saline conditions also showed significant variations in antioxidant levels and growth physiology. Results suggested that inoculation with PGPR Bacillus pumilus and Pseudomonas pseudoalcaligenes in salt-stressed plants could help to alleviate salt stress in the paddy.

  12. Grain size and temperature influence on the toughness of a CuAlBe shape memory alloy

    Energy Technology Data Exchange (ETDEWEB)

    Albuquerque, Victor Hugo C. de, E-mail: victor.albuquerque@fe.up.pt [Universidade Federal da Paraiba (UFPB), Departamento de Engenharia Mecanica (DEM), Laboratorio de Solidificacao Rapida LSR, Cidade Universitaria, S/N 58059-900 Joao Pessoa, PB (Brazil); Melo, Tadeu Antonio de A, E-mail: tadeu@lsr.ct.ufpb.br [Universidade Federal da Paraiba (UFPB), Departamento de Engenharia Mecanica (DEM), Laboratorio de Solidificacao Rapida LSR, Cidade Universitaria, S/N 58059-900 Joao Pessoa, PB (Brazil); Gomes, Rodinei M., E-mail: gomes@lsr.ct.ufpb.br [Universidade Federal da Paraiba (UFPB), Departamento de Engenharia Mecanica (DEM), Laboratorio de Solidificacao Rapida LSR, Cidade Universitaria, S/N 58059-900 Joao Pessoa, PB (Brazil); Lima, Severino Jackson G. de, E-mail: jackson@lsr.ct.ufpb.br [Universidade Federal da Paraiba (UFPB), Departamento de Engenharia Mecanica (DEM), Laboratorio de Solidificacao Rapida LSR, Cidade Universitaria, S/N 58059-900 Joao Pessoa, PB (Brazil); Tavares, Joao Manuel R.S., E-mail: tavares@fe.up.pt [Faculdade de Engenharia da Universidade do Porto (FEUP), Departamento de Engenharia Mecanica (DEMec)/Instituto de Engenharia Mecanica e Gestao Industrial INEGI, Rua Dr. Roberto Frias, S/N 4200-465 Porto (Portugal)

    2010-11-25

    Research highlights: {yields} This work evaluated the capacity of a CuAlBe alloy to absorb energy until rupture. {yields} The V-notch Charpy test was adopted at -150, -100, -50, 0, 50, 100 and 150 deg. C. {yields} Charpy tests were complemented by DSC, DSC with optical microscope and by SEM. {yields} First work to analyze the toughness of a CuAlBe alloy based on the Charpy test. {yields} The results are of relevant value to enhance the understanding of the CuAlBe alloy. - Abstract: This work is a study of the influence of grain size and temperature on the toughness of CuAlBe shape memory alloys with (CuAlBeNbNi) and without NbNi (CuAlBe) grain refiner elements. The toughness analysis was based on the V-notch Charpy impact test under temperatures of -150, -100, -50, 0, 50, 100 and 150 deg. C. A statistical analysis of the results led to the conclusion that the toughness of both alloys was influenced by temperature and grain size. The CuAlBeNbNi alloy absorbed higher impact energy than the CuAlBe alloy showing that the refining elements improved the toughness of the alloy. To confirm and complement these findings, the fracture surfaces were evaluated by stereomicroscopy. Smooth homogeneous surfaces and rough heterogonous surfaces were detected for the CuAlBeNbNi and CuAlBe alloys, respectively. Predominately brittle zones were confirmed by scanning electron microscopy in both alloys. Furthermore, to determine the phase transformation temperatures and the associated microstructures, the alloys were assessed by conventional differential scanning calorimetry (DSC) and DSC with optical microscopy.

  13. Molecular Analysis of Mixed Endometrial Carcinomas Shows Clonality in Most Cases.

    Science.gov (United States)

    Köbel, Martin; Meng, Bo; Hoang, Lien N; Almadani, Noorah; Li, Xiaodong; Soslow, Robert A; Gilks, C Blake; Lee, Cheng-Han

    2016-02-01

    Mixed endometrial carcinoma refers to a tumor that comprises 2 or more distinct histotypes. We studied 18 mixed-type endometrial carcinomas-11 mixed serous and low-grade endometrioid carcinomas (SC/EC), 5 mixed clear cell and low-grade ECs (CCC/EC), and 2 mixed CCC and SCs (CCC/SC), using targeted next-generation sequencing and immunohistochemistry to compare the molecular profiles of the different histotypes present in each case. In 16 of 18 cases there was molecular evidence that both components shared a clonal origin. Eight cases (6 EC/SC, 1 EC/CCC, and 1 SC/CCC) showed an SC molecular profile that was the same in both components. Five cases (3 CCC/EC and 2 SC/EC) showed a shared endometrioid molecular profile and identical mismatch-repair protein deficiency in both components. A single SC/EC case harbored the same POLE exonuclease domain mutation in both components. One SC/CCC and 1 EC/CCC case showed both shared and unique molecular features in the 2 histotype components, suggesting early molecular divergence from a common clonal origin. In 2 cases, there were no shared molecular features, and these appear to be biologically unrelated synchronous tumors. Overall, these results show that the different histologic components in mixed endometrial carcinomas typically share the same molecular aberrations. Mixed endometrial carcinomas most commonly occur through morphologic mimicry, whereby tumors with serous-type molecular profile show morphologic features of EC or CCC, or through underlying deficiency in DNA nucleotide repair, with resulting rapid accrual of mutations and intratumoral phenotypic heterogeneity. Less commonly, mixed endometrial carcinomas are the result of early molecular divergence from a common progenitor clone or are synchronous biologically unrelated tumors (collision tumors).

  14. Bacteriocin-like substance from Bacillus amyloliquefaciens shows remarkable inhibition of Acanthamoeba polyphaga.

    Science.gov (United States)

    Benitez, Lisianne Brittes; Caumo, Karin; Brandelli, Adriano; Rott, Marilise Brittes

    2011-03-01

    The effectiveness of a bacteriocin-like substance (BLS) produced by Bacillus amyloliquefaciens was tested against Acanthamoeba polyphaga strains, and its cytotoxic potential on Vero cells was investigated. Amebicidal activity of the purified BLS was tested by plate bioassays with concentrations ranging from 12.5 to 6,400 AU mL(-1). Damage to A. pholyphaga cells was monitored using an inverted microscope and counted in a Fuchs-Rosenthal chamber after 24, 48, and 72 h. According to the results obtained, the BLS showed remarkable amebicidal and amebostatic effect on A. polyphaga and showed no cytotoxicity on the Vero cells. These results may have great relevance in the development of new acanthamoebicidal compounds.

  15. SAA drift: Experimental results

    Science.gov (United States)

    Grigoryan, O. R.; Romashova, V. V.; Petrov, A. N.

    According to the paleomagnetic analysis there are variations of Earth’s magnetic field connected with magnetic moment changing. These variations affect on the South Atlantic Anomaly (SAA) location. Indeed different observations approved the existence of the SAA westward drift rate (0.1 1.0 deg/year) and northward drift rate (approximately 0.1 deg/year). In this work, we present the analysis of experimental results obtained in Scobeltsyn Institute of Nuclear Physics, Moscow State University (SINP MSU) onboard different Earth’s artificial satellites (1972 2003). The fluxes of protons with energy >50 MeV, gamma quanta with energy >500 keV and neutrons with energy 0.1 1.0 MeV in the SAA region have been analyzed. The mentioned above experimental data were obtained onboard the orbital stations Salut-6 (1979), MIR (1991, 1998) and ISS (2003) by the similar experimental equipment. The comparison of the data obtained during these two decades of investigations confirms the fact that the SAA drifts westward. Moreover the analysis of fluxes of electrons with energy about hundreds keV (Cosmos-484 (1972) and Active (Interkosmos-24, 1991) satellites) verified not only the SAA westward drift but northward drift also.

  16. LEARNING RESULTS TIME

    Directory of Open Access Journals (Sweden)

    Ignacio Polo Martínez

    2016-12-01

    Full Text Available In spite of the changes to education norms in our country in the last ten years, where we have tried to integrate the different curriculum components in teaching and learning design, it is still typical to detect (1 curriculum plans that encourage rote learning and (2 teachers that continue teaching in the same style in which they were taught as students, and/or simply copying the textbook, even though sometimes it doesn´t provide the appropriate teaching and reliable assessment which meets the needs of our society. The insufficient academic training of (1 teachers, superintendents, and education authority members and (2 staff assessment that assures the best teaching practices in the classrooms, may be contributing to the inability to improve our education system. With respect to these deficiencies, we may come to the conclusion that the inclusion of these competencies in the curriculum and evaluation is a superficial action to fullfill European education requirements, more than a real plan to improve teaching and learning processes, and therefore, learning results in our country.

  17. Simpler images, better results

    Science.gov (United States)

    Chance, Britton

    1999-03-01

    The very rapid development of optical technology has followed a pattern similar to that of nuclear magnetic resonance: first, spectroscopy and then imaging. The accomplishments in spectroscopy have been significant--among them, early detection of hematomas and quantitative oximetry (assuming that time and frequency domain instruments are used). Imaging has progressed somewhat later. The first images were obtained in Japan and USA a few years ago, particularly of parietal stimulation of the human brain. Since then, rapid applications to breast and limb, together with higher resolution of the brain now make NIR imaging of functional activation and tumor detection readily available, reliable and affordable devices. The lecture has to do with the applications of imaging to these three areas, particularly to prefrontal imaging of cognitive function, of breast tumor detection, and of localized muscle activation in exercise. The imaging resolution achievable in functional activation appears to be FWHM of 4 mm. The time required for an image is a few seconds or even much less. Breast image detection at 50 microsecond(s) ec/pixel results in images obtainable in a few seconds or shorter times (bandwidths of the kHz are available). Finally, imaging of the body organs is under study in this laboratory, particularly in the in utero fetus. It appears that the photon migration theory now leads to the development of a wide number of images for human subject tissue spectroscopy and imaging.

  18. Results from SNO

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Yuen-dat

    2001-10-01

    The Sudbury Neutrino Observatory (SNO) is an underground heavy water Cherenkov detector for studying solar neutrinos. SNO is capable of performing both flavor sensitive and flavor blind measurements of the solar neutrino flux. The first charged current (CC) measurement is found to be: {psi}{sub SNO}{sup CC}({nu}{sub e}) = 1.75 {+-} 0.07(stat.){sub -0.11}{sup +0.12}(sys.) {+-} 0.05 (theor.) x 10{sup 6} cm{sup -2}s{sup -1} and the elastic scattering fluxes (ES) is: {psi}{sub SNO}{sup ES}({nu}{sub x}) = 2.39 {+-} 0.34(stat.){sub -0.14}{sup +0.16} (sys.) x 10{sup 6} cm{sup -2}s{sup -1}. The {psi}{sub SNO}{sup CC}({nu}{sub e}) result, when combined with the high statistics elastic scattering (ES) measurement from Super-Kamiokande, provide a strong evidence for solar neutrino flavor transformation (3.3{sigma}). The deduced total solar neutrino flux is in good agreement with standard solar model predictions. No significant distortion in the energy spectrum is observed.

  19. ALOS-2 initial results

    Science.gov (United States)

    Kankaku, Yukihiro; Suzuki, Shinichi; Shimada, Masanobu

    2015-10-01

    The Advanced Land Observing Satellite-2 (ALOS-2) was launched from Tanegashima Space Center by H-IIA rocket successfully on 24th May 2014. ALOS-2 carries the Phased Array type L-band Synthetic Aperture Radar-2 (PALSAR-2) as the state-of-the-art L-band SAR system which succeeds to PALSAR onboard ALOS. PALSAR-2 uses almost whole bandwidth allocated for L-band active sensor of Earth Exploration Satellites Service specified by the Radio Regulation in order to realize the high resolution observation, and also, it transmits more than 6 kW power for lower Noise Equivalent Sigma Zero using 180 TRMs driven by Gallium Nitride (GaN) amplifier which is the first use in space. Furthermore, because ALOS-2 carries the SAR system only, PALSAR-2 antenna can be mounted under the satellite body. It enables to observe right-/left-looking observation by satellite maneuvering. And the high accuracy orbit control to maintain the satellite within 500 m radius tube against the reference orbit enables high coherence for the InSAR processing. Using these new technologies, ALOS-2 has been operating to fulfill the mission requirements such as disaster monitoring and so on. This document introduces the initial result of ALOS-2 from the first year operation.

  20. Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

    Science.gov (United States)

    England, Kathleen; Boshoff, Helena I M; Arora, Kriti; Weiner, Danielle; Dayao, Emmanuel; Schimel, Daniel; Via, Laura E; Barry, Clifton E

    2012-06-01

    The carbapenems imipenem and meropenem in combination with clavulanic acid reduced the bacterial burden in Mycobacterium tuberculosis-infected macrophages by 2 logs over 6 days. Despite poor stability in solution and a short half-life in rodents, treatment of chronically infected mice revealed significant reductions of bacterial burden in the lungs and spleens. Our results show that meropenem has activity in two in vivo systems, but stability and pharmacokinetics of long-term administration will offer significant challenges to clinical evaluation.

  1. A virtual experiment showing single particle motion on a linearly vibrating screen-deck

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    A virtual sieving experimental simulation system was built using physical simulation principles.The effects of vibration frequency and amplitude,the inclination angle of the screen-deck and the vibration direction angle of screen on single particle kinematics were predicted.Properties such as the average velocity and the average throw height were studied.The results show that the amplitude and the angle of vibration have a great effect on particle average velocity and average height.The vibration frequency ...

  2. [SENTIERI Project: results].

    Science.gov (United States)

    Crocetti, Emanuele; Pirastu, Roberta; Buzzoni, Carlotta; Minelli, Giada; Manno, Valerio; Bruno, Caterina; Fazzo, Lucia; Iavarone, Ivano; Pasetto, Roberto; Ricci, Paolo; Zona, Amerigo; Conti, Susanna; Comba, Pietro

    2014-01-01

    Of the 18 National Priority Contaminated Sites (NPCSs) analysed in this Report, some have a single source of environmental contamination (such as fluoro-edenite in Biancavilla). In most cases, however, we are looking at multiple heterogeneous sources of contamination. In this respect, the a priori causal evaluation of the association between diseases and environmental exposures in NPCSs, based on epidemiological evidence, can help trace the health impact back to specific types of environmental exposure. There are several cases in which the project's findings have been consistent with a priori evidence: stomach cancer (both genders, excess cancer incidence) in the Fidenza NPCS; stomach cancer (women, excess mortality, cancer incidence and hospital discharges) in the Laguna di Grado e Marano NPCS; excess hospitalisation from respiratory diseases in Brescia-Caffaro, Milazzo and Terni Papigno NPCSs; excesses for non-Hodgkin lymphomas and melanoma (incidence and hospitalisation in men and women) and breast cancer (incidence and hospital discharges, women) in Brescia-Caffaro NPCS. In preorder to properly evaluate the population's health profile, we must also observe whether results remain consistent for all three health outcomes or in both genders. The first is the case of excess mortality, cancer incidence and hospital discharges for bladder cancer (men) in Porto Torres and diseases of the urinary tract in the Basso bacino del fiume Chienti NPCS). Gender consistency is observed, for instance, for all cancer in Bolzano, Porto Torres, Venice, Litorale Domizio Flegreo, Priolo, and Taranto, for all causes in Taranto, Litorale Domizio Flegreo and Trieste. The health impact in the various NPCSs needs to be considered carefully and used as a springboard for further analytical research that could confirm and explain causal links to specific environmental exposures. The observations can, however, already be considered as a basis for mandatory primary prevention measures.

  3. Result-Based Public Governance

    DEFF Research Database (Denmark)

    Boll, Karen

    the performance measure that guides the inspectors’ inspection (or nudging) of the businesses. The analysis shows that although a result-based governance system is advocated on a strategic level, performance measures which are not ‘result-based’ are developed and used in the daily coordination of work. The paper......Within the public sector, many institutions are either steered by governance by targets or result-based governance. The former sets up quantitative internal production targets, while the latter advocates that production is planned according to outcomes which are defined as institution......-produced effects on individuals or businesses in society; effects which are often produced by ‘nudging’ the citizenry in a certain direction. With point of departure in these two governance-systems, the paper explores a case of controversial inspection of businesses’ negative VAT accounts and it describes...

  4. The information seeking and procurment needs of attendees at an industrial trade show

    Directory of Open Access Journals (Sweden)

    N. C. Bresler

    2009-12-01

    Full Text Available Purpose: The purpose of this article is to describe what attracts visitors to an industrial trade show, and to profile them. This will enable the show organisers to attract the right mix of exhibitors and fulfil their dual role of satisfying the needs of both attendees and exhibitors and improve the role of exhibitions in the latter's marketing mix. Problem investigated: The research seeks to elicit the attendance objectives of participants in order to ascertain their information seeking and procurement needs. This can be used to improve the marketing communication of both the organisers and exhibitors. Research methodology: The research design is a multi method, descriptive study. A non probability, judgemental sample was drawn; 1020 interviews were conducted per Electra Mining Africa expo in 2004 and 2006. Both open ended and fixed response questions were posed and due to the similarity of responses, 300 per show were analysed. The researcher fulfilled a participant observer role to enhance the validity and reliability of the findings. Findings/implications: The prime reason for visitation was to see what is new, discover, and gather information, and attendees were not disappointed in that. The trade shows attracted an informed, niche audience. Exhibitors gained access to key decision makers with buying influence. Attendees represented all roles in the buying process and intended to buy some capital items exhibited within the following year. Business contacts were made. The attraction and contact efficiency of the exhibition's were high and may result in conversion efficiency. In terms of market and geographical coverage it is a vertical international show. Originality: This paper contributes to limited research conducted on trade shows, especially in South Africa. It is unique in that it describes the effectiveness of an industrial trade show from a demand perspective in order to improve the facilitating role of exhibition organisers. It

  5. Using television shows to teach communication skills in internal medicine residency

    Directory of Open Access Journals (Sweden)

    Ma Irene

    2009-02-01

    Full Text Available Abstract Background To address evidence-based effective communication skills in the formal academic half day curriculum of our core internal medicine residency program, we designed and delivered an interactive session using excerpts taken from medically-themed television shows. Methods We selected two excerpts from the television show House, and one from Gray's Anatomy and featured them in conjunction with a brief didactic presentation of the Kalamazoo consensus statement on doctor-patient communication. To assess the efficacy of this approach a set of standardized questions were given to our residents once at the beginning and once at the completion of the session. Results Our residents indicated that their understanding of an evidence-based model of effective communication such as the Kalamazoo model, and their comfort levels in applying such model in clinical practice increased significantly. Furthermore, residents' understanding levels of the seven essential competencies listed in the Kalamazoo model also improved significantly. Finally, the residents reported that their comfort levels in three challenging clinical scenarios presented to them improved significantly. Conclusion We used popular television shows to teach residents in our core internal medicine residency program about effective communication skills with a focus on the Kalamazoo's model. The results of the subjective assessment of this approach indicated that it was successful in accomplishing our objectives.

  6. School-Aged Children and Adult Language Production in an Indonesian TV Show

    Directory of Open Access Journals (Sweden)

    Kisno

    2014-03-01

    Full Text Available The aim of this research was to find out the language produced by the school-aged children and the adult in a TV show. The study was carried out applying descriptive qualitative research design. The data for this research included the conversations between an adult (the host and three school-aged children. The data analysis procedures included- observing the video, transcribing the conversation, identifying the linguistics and non-linguistics features of the utterances, categorizing the language produced by the children and the adult, and interpreting the result of the analysis. The findings of data analysis showed that the five-year-old children produced one-word and two-word utterances rather than longer sentences. In contrast, the seven-year-old child produced longer sentences rather than one-word or two-word utterances. On the other hand, the host applied different ways and modified the way she produced language (‘caregiver speech’ or ‘motherese’ such as using exclamation, using gestures, using complimenting words, using intimate pronouns, and using direct instruction. The results obtained indicated that the school-aged children and the adult have their own ways in producing language in a TV show in Indonesia.

  7. Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.

    Directory of Open Access Journals (Sweden)

    Rick S Mitchell

    2004-08-01

    Full Text Available The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells. We compared retroviral vectors derived from human immunodeficiency virus (HIV, avian sarcoma-leukosis virus (ASLV, and murine leukemia virus (MLV. Effects of gene activity on integration targeting were assessed by transcriptional profiling of infected cells. Integration by HIV vectors, analyzed in two primary cell types and several cell lines, strongly favored active genes. An analysis of the effects of tissue-specific transcription showed that it resulted in tissue-specific integration targeting by HIV, though the effect was quantitatively modest. Chromosomal regions rich in expressed genes were favored for HIV integration, but these regions were found to be interleaved with unfavorable regions at CpG islands. MLV vectors showed a strong bias in favor of integration near transcription start sites, as reported previously. ASLV vectors showed only a weak preference for active genes and no preference for transcription start regions. Thus, each of the three retroviruses studied showed unique integration site preferences, suggesting that virus-specific binding of integration complexes to chromatin features likely guides site selection.

  8. Strains of the soil fungus Mortierella show different degradation potentials for the phenylurea herbicide diuron.

    Science.gov (United States)

    Ellegaard-Jensen, Lea; Aamand, Jens; Kragelund, Birthe B; Johnsen, Anders H; Rosendahl, Søren

    2013-11-01

    Microbial pesticide degradation studies have until now mainly focused on bacteria, although fungi have also been shown to degrade pesticides. In this study we clarify the background for the ability of the common soil fungus Mortierella to degrade the phenylurea herbicide diuron. Diuron degradation potentials of five Mortierella strains were compared, and the role of carbon and nitrogen for the degradation process was investigated. Results showed that the ability to degrade diuron varied greatly among the Mortierella strains tested, and the strains able to degrade diuron were closely related. Degradation of diuron was fastest in carbon and nitrogen rich media while suboptimal nutrient levels restricted degradation, making it unlikely that Mortierella utilize diuron as carbon or nitrogen sources. Degradation kinetics showed that diuron degradation was followed by formation of the metabolites 1-(3,4-dichlorophenyl)-3-methylurea, 1-(3,4-dichlorophenyl)urea and an hitherto unknown metabolite suggested to be 1-(3,4-dichlorophenyl)-3-methylideneurea.

  9. Impact of Medical TV Shows on Preprocedural Fear of Surgical In-House Patients.

    Science.gov (United States)

    Witzel, Kai; Koch, Horst J; Kaminski, Cornelia

    2017-01-21

    Background and Hypotheses: The growing number of medical television series and the increasing amount of time people spend watching TV will have an influence on what they expect from their treatment in a hospital. We suspect that reality as presented in the media and the actual reality of hospitals are not always conceived of as two different worlds. Many medical TV shows present dramatic, life-threatening operations much more often than they occur in reality. Patients who frequently watch such shows might be induced to believe that even routine operations are often dangerous, which could result in higher levels of fear before such an operation. We suspect then that there is a significant relation between preoperative levels of fear and TV viewing habits.

  10. Basic results on braid groups

    CERN Document Server

    Gonzalez-Meneses, Juan

    2010-01-01

    These are Lecture Notes of a course given by the author at the French-Spanish School "Tresses in Pau", held in Pau (France) in October 2009. It is basically an introduction to distinct approaches and techniques that can be used to show results in braid groups. Using these techniques we provide several proofs of well known results in braid groups, namely the correctness of Artin's presentation, that the braid group is torsion free, or that its center is generated by the full twist. We also recall some solutions of the word and conjugacy problems, and that roots of a braid are always conjugate. We also describe the centralizer of a given braid. Most proofs are classical ones, using modern terminology. I have chosen those which I find simpler or more beautiful.

  11. Sterols from Mytilidae show anti-aging and neuroprotective effects via anti-oxidative activity.

    Science.gov (United States)

    Sun, Yujuan; Lin, Yanfei; Cao, Xueli; Xiang, Lan; Qi, Jianhua

    2014-11-25

    For screening anti-aging samples from marine natural products, K6001 yeast strain was employed as a bioassay system. The active mussel extract was separated to give an active sterol fraction (SF). SF was further purified, and four sterol compounds were obtained. Their structures were determined to be cholesterol (CHOL), brassicasterol, crinosterol, and 24-methylenecholesterol. All compounds showed similar anti-aging activity. To understand the action mechanism involved, anti-oxidative experiments, reactive oxygen species (ROS) assays, and malondialdehyde (MDA) tests were performed on the most abundant compound, CHOL. Results indicated that treatment with CHOL increases the survival rate of yeast under oxidative stress and decreases ROS and MDA levels. In addition, mutations of uth1, skn7, sod1, and sod2, which feature a K6001 background, were employed and the lifespans of the mutations were not affected by CHOL. These results demonstrate that CHOL exerts anti-aging effects via anti-oxidative stress. Based on the connection between neuroprotection and anti-aging, neuroprotective experiments were performed in PC12 cells. Paraquat was used to induce oxidative stress and the results showed that the CHOL and SF protect the PC12 cells from the injury induced by paraquat. In addition, these substance exhibited nerve growth factor (NGF) mimic activities again confirmed their neuroprotective function.

  12. NEW RESULTS ON ESTIMATES FOR SINGULAR VALUES

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    New results are provided to estimate matrix singular values in terms of partial absolute deleted row sums and column sums. Illustrative examples are presented to show comparisons with results in literature.

  13. Feeding practice and influence on selected blood parameters in show jumping horses competing in Switzerland.

    Science.gov (United States)

    Brunner, J; Liesegang, A; Weiss, S; Wichert, B

    2015-08-01

    The aim of this study was to compare the nutritional management of show jumping horses in practice with recommendations from the literature. Additionally, the effects of these feeding practices on several blood metabolic parameters before and after exercise were studied. Blood samples were collected in the field from 27 different horses at 71 trials on the level M1 to S2 show jumping competitions in Switzerland and questionnaires on feeding practice of the studied horses were evaluated. The questionnaires revealed that during training and on tournament days horses received on average 3.1 kg of concentrate per day (min. 2.0 kg, max. 6.6 kg) divided into two to three meals. The horses were fed on average 6.9 kg of roughage per day (min. 4.0 kg, max. 13.0 kg). Additionally, it was observed that the horses received the last meal on average 6 h 10 min (min. 1 h 50 min, max. 12 h 30 min) before the start of the first show jumping turn, respectively, 7 h 30 min (min 1 h 50 min, max. 13 h 0 min) before the second turn. Seven horses (35%) had access to hay waiting in the trailer between two turns. The statistical analysis revealed no significant influence of the concentrate feeding time point on lactate, triglyceride and insulin levels, but a significant influence on free fatty acids (FFA) and blood glucose concentrations. Roughage feeding of the show jumping horses 2-4 h prior to exercise revealed the most remarkable changes in blood parameters during the show jumping course. These results received under field conditions should be approved in future under standardized conditions.

  14. An expanded phylogeny of social amoebas (Dictyostelia shows increasing diversity and new morphological patterns

    Directory of Open Access Journals (Sweden)

    Stephenson Steven L

    2011-03-01

    Full Text Available Abstract Background Social Amoebae or Dictyostelia are eukaryotic microbes with a unique life cycle consisting of both uni- and multicellular stages. They have long fascinated molecular, developmental and evolutionary biologists, and Dictyostelium discoideum is now one of the most widely studied eukaryotic microbial models. The first molecular phylogeny of Dictyostelia included most of the species known at the time and suggested an extremely deep taxon with a molecular depth roughly equivalent to Metazoa. The group was also shown to consist of four major clades, none of which correspond to traditional genera. Potential morphological justification was identified for three of the four major groups, on the basis of which tentative names were assigned. Results Over the past four years, the Mycetozoan Global Biodiversity Survey has identified many new isolates that appear to be new species of Dictyostelia, along with numerous isolates of previously described species. We have determined 18S ribosomal RNA gene sequences for all of these new isolates. Phylogenetic analyses of these data show at least 50 new species, and these arise from throughout the dictyostelid tree breaking up many previously isolated long branches. The resulting tree now shows eight well-supported major groups instead of the original four. The new species also expand the known morphological diversity of the previously established four major groups, violating nearly all previously suggested deep morphological patterns. Conclusions A greatly expanded phylogeny of Dictyostelia now shows even greater morphological plasticity at deep taxonomic levels. In fact, there now seem to be no obvious deep evolutionary trends across the group. However at a finer level, patterns in morphological character evolution are beginning to emerge. These results also suggest that there is a far greater diversity of Dictyostelia yet to be discovered, including novel morphologies.

  15. New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases.

    Science.gov (United States)

    Hölscher, Christian

    2014-11-01

    Type 2 diabetes is a risk factor for Alzheimer's disease and Parkinson's disease. Insulin signaling in the brains of people with Alzheimer's disease or Parkinson's disease is impaired. Preclinical studies of growth factors showed impressive neuroprotective effects. In animal models of Alzheimer's disease and Parkinson's disease, insulin, glia-derived neurotrophic factor, or analogues of the incretin glucagon-like peptide-1 prevented neurodegenerative processes and improved neuronal and synaptic functionality in Alzheimer's disease and Parkinson's disease. On the basis of these promising findings, several clinical trials are ongoing with the first encouraging clinical results published. This gives hope for developing effective treatments for Alzheimer's disease and Parkinson's disease that are currently unavailable.

  16. Excessive users of violent video games do not show emotional desensitization: an fMRI study.

    Science.gov (United States)

    Szycik, Gregor R; Mohammadi, Bahram; Hake, Maria; Kneer, Jonas; Samii, Amir; Münte, Thomas F; Te Wildt, Bert T

    2016-04-16

    Playing violent video games have been linked to long-term emotional desensitization. We hypothesized that desensitization effects in excessive users of violent video games should lead to decreased brain activations to highly salient emotional pictures in emotional sensitivity brain regions. Twenty-eight male adult subjects showing excessive long-term use of violent video games and age and education matched control participants were examined in two experiments using standardized emotional pictures of positive, negative and neutral valence. No group differences were revealed even at reduced statistical thresholds which speaks against desensitization of emotion sensitive brain regions as a result of excessive use of violent video games.

  17. Genetic connections between dressage and show-jumping horses in Dutch Warmblood horses

    DEFF Research Database (Denmark)

    Rovere, Gabriel; Madsen, Per; Norberg, Elise

    2014-01-01

    During the last decades, the breeding practice within the Dutch Warmblood studbook (KWPN) has resulted in an increasing specialisation of horses into show-jumping (JH) and dressage (DH). The objective of this study was to describe the effect of the specialisation on the connectedness between...... the subpopulations of JH and DH horses registered by KWPN. The subpopulations comprised 23,800 JH horses and 18,125 DH horses, born between 1995 and 2009. Genetic similarity (GS), genetic pool in common (GCx) based on the marginal genetic contribution of common ancestors and coefficient of relationship (r) between...

  18. NCV Flow Diagnostic Test Results

    Science.gov (United States)

    Cappuccio, Mina

    1999-01-01

    There were two objectives for this test. First, was to assess the reasons why there is approximately 1.5 drag counts (cts) discrepancy between measured and computed drag improvement of the Non-linear Cruise Validation (NCV) over the Technology Concept Airplane (TCA) wing body (WB) configurations. The Navier-Stokes (N-S) pre-test predictions from Boeing Commercial Airplane Group (BCAG) show 4.5 drag cts of improvement for NCV over TCA at a lift coefficient (CL) of 0. I at Mach 2.4. The pre-test predictions from Boeing Phantom Works - Long Beach, BPW-LB, show 3.75 drag cts of improvement. BCAG used OVERFLOW and BPW-LB used CFL3D. The first test entry to validate the improvement was held at the NASA Langley Research Center (LARC) UPV;T, test number 1687. The experimental results showed that the drag improvement was only 2.6 cts, not accounting for laminar run and trip drag. This is approximately 1.5 cts less than predicted computationally. In addition to the low Reynolds Number (RN) test, there was a high RN test in the Boeing Supersonic Wind Tunnel (BSWT) of NCV and TCA. BSV@T test 647 showed that the drag improvement of NCV over TCA was also 2.6 cts, but this did account for laminar run and trip drag. Every effort needed to be done to assess if the improvement measured in LaRC UPWT and BSWT was correct. The second objective, once the first objective was met, was to assess the performance increment of NCV over TCA accounting for the associated laminar run and trip drag corrections in LaRC UPWT. We know that the configurations tested have laminar flow on portions of the wing and have trip drag due to the mechanisms used to force the flow to go from laminar to turbulent aft of the transition location.

  19. A Technology and Application of ShowModalDialog Popup Window Scraping%一种ShowModalDialog弹出窗口抓取技术及应用

    Institute of Scientific and Technical Information of China (English)

    孙长翔; 陈秀国

    2014-01-01

    ShowModalDialog弹出窗口抓取问题上,介绍了Web数据抓取技术,分析了Web数据抓取的原理,并重点讨论了利用SPY++工具来实现ShowModalDialog弹出窗口中数据的抓取和处理.

  20. Radio Show on Books and Libraries as a Means of Promoting the Public Library: Marking the 200th Edition of the Show Tvoja,

    Directory of Open Access Journals (Sweden)

    Peter Pavletič

    2014-04-01

    Full Text Available ABSTRACTSince 2004, the Ciril Kosmač Library of Tolmin has been continuously preparing a radio show on books and libraries on the local radio station Alpski val. The show has been used as an advertising platform or as a means of primary library promotion. The radio show is regarded as one of the tools of what is termed market communication, and it is intended to provide broad public information on the services of a public library, to promote the library’s activities and holdings and to foster a reading culture. The aim of the show is to stimulate the potential user interest in visiting and using the services of a public library, to expand the circle of users and consequently raise the number of visits and library loans. The title of the show, its audio image, target audience, metapromotion and substantive concept are all key to planning the radio show on books and libraries. The radio show is an example of an effective tool that helps to establish the library’s ties with the local community. This example of best practices shows that it is worth pursuing this activity in Slovenia’s public libraries and highlighting it on their websites.

  1. Lithium inclusion in indium metal-organic frameworks showing increased surface area and hydrogen adsorption

    Directory of Open Access Journals (Sweden)

    Mathieu Bosch

    2014-12-01

    Full Text Available Investigation of counterion exchange in two anionic In-Metal-Organic Frameworks (In-MOFs showed that partial replacement of disordered ammonium cations was achieved through the pre-synthetic addition of LiOH to the reaction mixture. This resulted in a surface area increase of over 1600% in {Li [In(1,3 − BDC2]}n and enhancement of the H2 uptake of approximately 275% at 80 000 Pa at 77 K. This method resulted in frameworks with permanent lithium content after repeated solvent exchange as confirmed by inductively coupled plasma mass spectrometry. Lithium counterion replacement appears to increase porosity after activation through replacement of bulkier, softer counterions and demonstrates tuning of pore size and properties in MOFs.

  2. Laboratory study of fungal bioreceptivity of different fractions of composite flooring tiles showing efflorescence.

    Science.gov (United States)

    Masaphy, Segula; Lavi, Ido; Sultz, Stephan; Zabari, Limor

    2014-06-01

    Fungi can grow in extreme habitats, such as natural stone and mineral building materials, sometimes causing deterioration. Efflorescence-concentrated salt deposits-results from water movement through building material; it can damage masonry materials and other bricks. Fungal isolate KUR1, capable of growth on, and dissolution of stone chips composing terrazzo-type floor tiles, was isolated from such tiles showing fiber-like crystalline efflorescence. The isolate's ribosomal DNA sequences were 100 % identical to those of Nigrospora sphaerica. The ability of KUR1 to colonize and degrade the different stone chips composing the tiles was studied in axenic culture experiments. When exposed to each of the different mineral chip types composed of dolomite, calcite, or calcite-apatite mineral in low-nutrition medium, the fungus showed selective nutrient consumption, and different growth and stone mineral dissolution rates. Micromorphological examination of the fungus-colonized chips by electron microscopy showed the production of a fungal biofilm with thin films around the hyphae on the surface of the examined chips and disintegration of the calcite-apatite fraction. More than 70 % dissolution of the introduced powdered (mineral was obtained within 10 days of incubation for the soft calcite-apatite fraction.

  3. Live Reporting in a News / Current Affairs TV Show as a Factor of (Non Credibility

    Directory of Open Access Journals (Sweden)

    Tena Perišin

    2010-12-01

    Full Text Available Only a perfunctory glance at the content of current aff airs/news programs makes it clear that in just a few years time, live reporting on Croatian TV news shows has increased dramatically. Technologicaladvancements, the equipping of TV stations with mobile satellite vans, and the pressure of competition have all resulted in increased instances of live reporting. When investigating news values, pictureand sound, as well as the possibility of immediate, timely reporting represent the key characteristics of TV journalism. In this context, live reports, as part of a news segment, should add to the authenticity and credibility of the program. Currently, however, TV broadcasting houses attempt to best one another in the number of live broadcasts as a means to purport a higher quality of their program. The direct address to the camera turns a reporter from an anonymous bearer of information into the “main star”. The figures accumulated on the extent of this form used in a news show do not determine the professional level of the editorial policy. Live reporting cannot be regarded as news value if other news values are neglected in the process. Recent research shows that live reports, in most cases, have been stripped of the initial notion of reporting on important and recent events. As such, they are becoming less of a justifi ed element in the creation of news.

  4. Amphibian DNA shows marked genetic structure and tracks pleistocene climate change in northeastern Brazil.

    Science.gov (United States)

    Carnaval, Ana Carolina; Bates, John M

    2007-12-01

    The glacial refugia paradigm has been broadly applied to patterns of species dynamics and population diversification. However, recent geological studies have demonstrated striking Pleistocene climate changes in currently semiarid northeastern Brazil at time intervals much more frequent than the climatic oscillations associated with glacial and interglacial periods. These geomorphic data documented recurrent pulses of wet regimes in the past 210,000 years that correlate with climate anomalies affecting multiple continents. While analyzing DNA sequences of two mitochondrial genes (cytochrome b and NADH-dehydrogenase subunit 2) and one nuclear marker (cellular-myelocytomatosis proto-oncogene) in the forest-associated frogs Proceratophrys boiei and Ischnocnema gr. ramagii, we found evidence of biological responses consistent with these pluvial maxima events. Sampled areas included old, naturally isolated forest enclaves within the semiarid Caatinga, as well as recent man-made fragments of humid coastal Atlantic forest. Results show that mtDNA lineages in enclave populations are monophyletic or nearly so, whereas nonenclave populations are polyphyletic and more diverse. The studied taxa show evidence of demographic expansions at times that match phases of pluvial maxima inferred from geological data. Divergence times between several populations fall within comparatively drier intervals suggested by geomorphology. Mitochondrial and nuclear data show local populations to be genetically structured, with some high levels of differentiation that suggest the need of further taxonomic work.

  5. Carbon nanotube fiber microelectrodes show a higher resistance to dopamine fouling.

    Science.gov (United States)

    Harreither, Wolfgang; Trouillon, Raphaël; Poulin, Philippe; Neri, Wilfrid; Ewing, Andrew G; Safina, Gulnara

    2013-08-06

    We have compared the properties and resistance to DA fouling of a carbon nanotube fiber (CNTF) microelectrode to a traditional carbon fiber (CF) microelectrode. These two materials show comparable electrochemical activities for outer-sphere and inner-sphere redox reactions. Although the CNTF might have a higher intrinsic RC constant, thus limiting its high-frequency behavior, the CNTF shows a significantly higher durability than the CF in terms of electrode stability. During constant oxidation of 100 μM DA, the signal measured by the CNTF microelectrode shows a 2-h window over which no decrease in current is observed. Under the same conditions, the current obtained at the CF microelectrode decreases by almost 50%. A model of the fouling process, assuming the formation of growing patches of insulator on the surface, has been compared to the data. This model is found to be in good agreement with our results and indicates a growth rate of the patches in the 0.1-2 nm s(-1) range.

  6. Phantom of the Universe: A State-of-the-Art Planetarium Show on Dark Matter

    Science.gov (United States)

    Barnett, Michael

    2016-03-01

    Phantom of the Universe is a planetarium show premiering in 2016 that will showcase an exciting exploration of dark matter, from the Big Bang to the Large Hadron Collider. The show will reveal the first hints of its existence through the eyes of Fritz Zwicky. Viewers will marvel at the astral choreography witnessed by Vera Rubin in the Andromeda galaxy. They will plummet deep underground to see the most sensitive dark matter detector on Earth. From there, they will end the journey at the Large Hadron Collider, speeding alongside particles before they collide in visually stunning explosions of light and sound, and learning how scientists around the world are collaborating to track down the constituent of dark matter. The show will be offered to planetariums worldwide free of charge. It will feature music composed by Mickey Hart (Apocalypse Now, The Twilight Zone, The Grateful Dead) and narration by Academy-Award winning actress Tilda Swinton, and showcase the creativity and directing prowess of Joao Pequenao and the writing and producing talents of award-winning filmmaker, Carey Ann Strelecki. See a flattened preview (with resulting distortions) at: http://PhantomOfTheUniverse.com/

  7. Serbs, the craziest of all – TV comedy show "Kursadžije" by Grand Production

    Directory of Open Access Journals (Sweden)

    Marija Krstić

    2016-02-01

    Full Text Available This paper is the result of research done on the TV comedy show (series "Kursadžije" by Grand Production. The attention is directed towards understanding the motives of the Fool (buffoon which appears as the characteristic of the main characters in the show. Kursadžije (a rough translation would be Course-attending-people are attendants of a course for Special Balkan Forces and they are the representatives of the countries that constituted the former Socialistic Federative Republic of Yugoslavia. By using the theoretic guidelines of Klappe’s about the Fool as a social type, and the analysis of V.Trifunovic, I will demonstrate why all of the Kursadžija’s are Fools and how they are different one from the other based on their different follies (buffoonery, craziness. Having in mind that this is a Serbian TV show and that the Serbian attendant of that course, Gedža Crazy Milojko (the American equivalent of Gedža could be Redneck or Hillbilly, is the only one who has the term "Crazy" (Fool in his name, I will particularly pay attention to the motive of "Serbian craziness", and examine is it a way to emphasize how special the Serbs are, how unique and unbeatably exotic, i.e., why is the "Serbian craziness" valued as a positive one.

  8. Listeria monocytogenes isolated from food samples from a Romanian black market show distinct virulence profiles.

    Science.gov (United States)

    Ciolacu, Luminita; Nicolau, Anca Ioana; Wagner, Martin; Rychli, Kathrin

    2015-09-16

    Listeria monocytogenes is a facultative intracellular foodborne pathogen responsible for listeriosis. In a recent study, in which we investigated neglected exogenous routes of transmission of foodborne pathogens into the European Union, we have isolated 15 L. monocytogenes strains in food products, which were imported from the Republic of Moldavia to Romania and illegally sold at a local market. The aim of this study was to characterize the subtype and virulence potential of these 15 L. monocytogenes strains. Multilocus sequence typing revealed that these L. monocytogenes strains belong to six different sequence types (ST2, ST8, ST9, ST20, ST121 and ST155). In addition, in vitro virulence assays using human intestinal epithelial Caco2 and macrophage-like THP1 cells showed a high strain variability regarding the invasion efficiency in Caco2 cells (0.98-2.78%) and the intracellular growth rate in both cell types. Both ST121 strains and the ST9 isolate were unable to invade Caco2 cells, and all ST155 strains showed no proliferation inside macrophages and revealed low cytotoxicity. Furthermore we performed sequence analysis of three main virulence factors: PrfA, internalin A (InlA) and listeriolysin O (LLO). The Romanian food isolates showed a high diversity in the InlA and LLO amino acid sequences, whereas the amino acid sequence of PrfA of all strains was identical. Overall, the amino acid sequences of PrfA, InlA and LLO were identical for strains belonging to the same ST. We detected in total 30 different amino acid substitutions, resulting in seven different InlA variants, two of which have not yet been described. The three strains, which were unable to invade Caco2 cells, harboured a premature stop codon resulting in truncated InlA. Furthermore, we detected four different amino acid substitutions in the LLO sequence, which are present in four variants. The number of LLO mutations correlates negatively with intracellular growth in Caco2 and THP1 cells and

  9. Schizophrenia spectrum disorders show reduced specificity and less positive events in mental time travel

    Directory of Open Access Journals (Sweden)

    Xing-jie Chen

    2016-07-01

    Full Text Available Mental time travel refers to the ability to recall past events and to imagine possible future events. Schizophrenia patients have problems in remembering specific personal experiences in the past and imagining what will happen in the future. This study aimed to examine episodic past and future thinking in schizophrenia spectrum disorders including schizophrenia patients and individuals with schizotypal personality disorder (SPD proneness who are at risk for developing schizophrenia. Thirty-two schizophrenia patients, 30 SPD proneness individuals, and 33 healthy controls participated in the study. The Sentence Completion for Events from the Past Test (SCEPT and the Sentence Completion for Events in the Future Test (SCEFT were used to measure past and future thinking abilities. Results showed that schizophrenia patients showed significantly reduced specificity in recalling past and imagining future events, they generated less proportion of specific and extended events compared to healthy controls. SPD proneness individuals only generated less extended events compared to healthy controls. The reduced specificity was mainly manifested in imagining future events. Both schizophrenia patients and SPD proneness individuals generated less positive events than controls. These results suggest that mental time travel impairments in schizophrenia spectrum disorders and have implications for understanding their cognitive and emotional deficits.

  10. Fifteen million years of evolution in the Oryza genus shows extensive gene family expansion.

    Science.gov (United States)

    Jacquemin, Julie; Ammiraju, Jetty S S; Haberer, Georg; Billheimer, Dean D; Yu, Yeisoo; Liu, Liana C; Rivera, Luis F; Mayer, Klaus; Chen, Mingsheng; Wing, Rod A

    2014-04-01

    In analyzing gene families in the whole-genome sequences available for O. sativa (AA), O. glaberrima (AA), and O. brachyantha (FF), we observed large size expansions in the AA genomes compared to FF genomes for the super-families F-box and NB-ARC, and five additional families: the Aspartic proteases, BTB/POZ proteins (BTB), Glutaredoxins, Trypsin α-amylase inhibitor proteins, and Zf-Dof proteins. Their evolutionary dynamic was investigated to understand how and why such important size variations are observed between these closely related species. We show that expansions resulted from both amplification, largely by tandem duplications, and contraction by gene losses. For the F-box and NB-ARC gene families, the genes conserved in all species were under strong purifying selection while expanded orthologous genes were under more relaxed purifying selection. In F-box, NB-ARC, and BTB, the expanded groups were enriched in genes with little evidence of expression, in comparison with conserved groups. We also detected 87 loci under positive selection in the expanded groups. These results show that most of the duplicated copies in the expanded groups evolve neutrally after duplication because of functional redundancy but a fraction of these genes were preserved following neofunctionalization. Hence, the lineage-specific expansions observed between Oryza species were partly driven by directional selection.

  11. Schizophrenia Spectrum Disorders Show Reduced Specificity and Less Positive Events in Mental Time Travel

    Science.gov (United States)

    Chen, Xing-jie; Liu, Lu-lu; Cui, Ji-fang; Wang, Ya; Chen, An-tao; Li, Feng-hua; Wang, Wei-hong; Zheng, Han-feng; Gan, Ming-yuan; Li, Chun-qiu; Shum, David H. K.; Chan, Raymond C. K.

    2016-01-01

    Mental time travel refers to the ability to recall past events and to imagine possible future events. Schizophrenia (SCZ) patients have problems in remembering specific personal experiences in the past and imagining what will happen in the future. This study aimed to examine episodic past and future thinking in SCZ spectrum disorders including SCZ patients and individuals with schizotypal personality disorder (SPD) proneness who are at risk for developing SCZ. Thirty-two SCZ patients, 30 SPD proneness individuals, and 33 healthy controls participated in the study. The Sentence Completion for Events from the Past Test (SCEPT) and the Sentence Completion for Events in the Future Test were used to measure past and future thinking abilities. Results showed that SCZ patients showed significantly reduced specificity in recalling past and imagining future events, they generated less proportion of specific and extended events compared to healthy controls. SPD proneness individuals only generated less extended events compared to healthy controls. The reduced specificity was mainly manifested in imagining future events. Both SCZ patients and SPD proneness individuals generated less positive events than controls. These results suggest that mental time travel impairments in SCZ spectrum disorders and have implications for understanding their cognitive and emotional deficits. PMID:27507958

  12. Diabetes patients show different time-course of myocardial perfusion improvement after coronary artery bypass grafting

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. J.; Seok, J. W.; Eo, J. S. [Seoul National University Hospital, Seoul (Korea, Republic of)] (and others)

    2005-07-01

    Diabetes mellitus is an independent risk factor of cardiovascular disease. Diabetes is known to cause microangiopathy. The microangiopathy is hardly detectable on the coronary angiography. Myocardial perfusion imaging shows the resultant perfusion status which reflects the microangiopathy. For patients who underwent revascularization, the microangiopathy could affect the myocardial perfusion improvement. Diabetes patients probably experience the different myocardial perfusion improvement as compared to the non-diabetes patients although they have similar angiographic findings. The aim of this study is to find out whether there is a time-course difference of perfusion improvement between the diabetes and non diabetes patients who showed patent angiographic findings after coronary artery grafting surgery (CABG). A total of 129 patients who underwent coronary artery bypass grafting surgery were enrolled in this study. Myocardial SPECTs performed at previous, short-term (3 month), and mid-term (1 year) to CABG. One-year follow up angiography was done 411{+-}121 days after surgery. Graft patency was determined according to the FitzGibbon et al. Segments were assigned to vascular territories using a 20 segment model. The segments of excellent patency were included in this study. Time course differences of concerned segments were analyzed using RMANOVA. The number of segments enrolled was 764 of diabetes and 1083 of non-diabetes. At short-term follow up, reversibility score was 2.8{+-}8.1% in diabetes and 0.3{+-}7.5% in non-diabetes. At long-term follow up, reversibility score was 1.8{+-}8.0% in diabetes and 0.1{+-}7.3% in non-diabetes. The time-course of reversibility score was significantly different between the diabetes and non diabetes (p<0.001) Diabetic segments showed high residual reversibility score than non-diabetic segments after CABG although the angiographic finding was patent in both groups. This result is maybe attributable to microangiopathy induced by

  13. Arabidopsis Profilin Isoforms, PRF1 and PRF2Show Distinctive Binding Activities and Subcellular Distributions

    Institute of Scientific and Technical Information of China (English)

    Feng Wang; Yanping Jing; Zhen Wang; Tonglin Mao; Jozef (S)amaj; Ming Yuan; Haiyun Ren

    2009-01-01

    Profilin is an actin-binding protein that shows complex effects on the dynamics of the actin cytoskeleton. There are five profilin isoforms in Arabidopsis thaliana L. However, it is still an open question whether these isoforms are functionally different. In the present study, two profilin isoforms from Arabidopsis, PRF1 and PRF2 were fused with green fluorescent protein (GFP) tag and expressed in Escherichia coli and A. thaliana in order to compare their biochemical properties in vitro and their cellular distributions in vivo. Biochemical analysis revealed that fusion proteins of GFP-PRF1 and GFP-PRF2 can bind to poly-L-proline and G-actin showing remarkable differences. GFP-PRF1 has much higher affinities for both poly-L-proline and G-actin compared with GFP-PRF2. Observations of living cells in stable transgsnic A. thaliana lines revealed that 35S::GFP-PRF1 formed a filamentous network, while 35S::GFP-PRF2 formed polygonal meshes. Results from the treatment with latrunculin A and a subsequent recovery experiment indicated that filamentous alignment of GFP-PRF1 was likely associated with actin filaments. However, GFP-PRF2 localized to polygonal meshes resembling the endoplasmic reticulum. Our results provide evidence that Arabidopsis profllin isoforms PRF1 and PRF2 have different biochemical affinities for poly-L-proline and G-actin, and show distinctive Iocalizations in living cells. These data suggest that PRF1 and PRF2 are functionally different isoforms.

  14. Consistently Showing Your Best Side? Intra-individual Consistency in #Selfie Pose Orientation.

    Science.gov (United States)

    Lindell, Annukka K

    2017-01-01

    Painted and photographic portraits of others show an asymmetric bias: people favor their left cheek. Both experimental and database studies confirm that the left cheek bias extends to selfies. To date all such selfie studies have been cross-sectional; whether individual selfie-takers tend to consistently favor the same pose orientation, or switch between multiple poses, remains to be determined. The present study thus examined intra-individual consistency in selfie pose orientations. Two hundred selfie-taking participants (100 male and 100 female) were identified by searching #selfie on Instagram. The most recent 10 single-subject selfies for the each of the participants were selected and coded for type of selfie (normal; mirror) and pose orientation (left, midline, right), resulting in a sample of 2000 selfies. Results indicated that selfie-takers do tend to consistently adopt a preferred pose orientation (α = 0.72), with more participants showing an overall left cheek bias (41%) than would be expected by chance (overall right cheek bias = 31.5%; overall midline bias = 19.5%; no overall bias = 8%). Logistic regression modellng, controlling for the repeated measure of participant identity, indicated that sex did not affect pose orientation. However, selfie type proved a significant predictor when comparing left and right cheek poses, with a stronger left cheek bias for mirror than normal selfies. Overall, these novel findings indicate that selfie-takers show intra-individual consistency in pose orientation, and in addition, replicate the previously reported left cheek bias for selfies and other types of portrait, confirming that the left cheek bias also presents within individuals' selfie corpora.

  15. Task control signals in pediatric Tourette syndrome show evidence of immature and anomalous functional activity

    Directory of Open Access Journals (Sweden)

    Jessica A Church

    2009-11-01

    Full Text Available Tourette Syndrome (TS is a pediatric movement disorder that may affect control signaling in the brain. Previous work has proposed a dual-networks architecture of control processing involving a task-maintenance network and an adaptive control network (Dosenbach et al., 2008. A prior resting-state functional connectivity MRI (rs-fcMRI analysis in TS has revealed functional immaturity in both putative control networks, with “anomalous” correlations (i.e. correlations outside the typical developmental range limited to the adaptive control network (Church et al., 2009. The present study used functional MRI (fMRI to study brain activity related to adaptive control (by studying start-cues signals, and to task-maintenance (by studying signals sustained across a task set. Two hypotheses from the previous rs-fcMRI results were tested. First, adaptive control (i.e., start-cue activity will be altered in TS, including activity inconsistent with typical development (“anomalous”. Second, group differences found in task maintenance (i.e., sustained activity will be consistent with functional immaturity in TS. We examined regions found through a direct comparison of adolescents with and without TS, as well as regions derived from a previous investigation that showed differences between unaffected children and adults. The TS group showed decreased start-cue signal magnitude in regions where start-cue activity is unchanged over typical development, consistent with anomalous adaptive control. The TS group also had higher magnitude sustained signals in frontal cortex regions that overlapped with regions showing differences over typical development, consistent with immature task maintenance in TS. The results demonstrate task-related fMRI signal differences anticipated by the atypical functional connectivity found previously in adolescents with TS, strengthening the evidence for functional immaturity and anomalous signaling in control networks in adolescents

  16. Consistently Showing Your Best Side? Intra-individual Consistency in #Selfie Pose Orientation

    Science.gov (United States)

    Lindell, Annukka K.

    2017-01-01

    Painted and photographic portraits of others show an asymmetric bias: people favor their left cheek. Both experimental and database studies confirm that the left cheek bias extends to selfies. To date all such selfie studies have been cross-sectional; whether individual selfie-takers tend to consistently favor the same pose orientation, or switch between multiple poses, remains to be determined. The present study thus examined intra-individual consistency in selfie pose orientations. Two hundred selfie-taking participants (100 male and 100 female) were identified by searching #selfie on Instagram. The most recent 10 single-subject selfies for the each of the participants were selected and coded for type of selfie (normal; mirror) and pose orientation (left, midline, right), resulting in a sample of 2000 selfies. Results indicated that selfie-takers do tend to consistently adopt a preferred pose orientation (α = 0.72), with more participants showing an overall left cheek bias (41%) than would be expected by chance (overall right cheek bias = 31.5%; overall midline bias = 19.5%; no overall bias = 8%). Logistic regression modellng, controlling for the repeated measure of participant identity, indicated that sex did not affect pose orientation. However, selfie type proved a significant predictor when comparing left and right cheek poses, with a stronger left cheek bias for mirror than normal selfies. Overall, these novel findings indicate that selfie-takers show intra-individual consistency in pose orientation, and in addition, replicate the previously reported left cheek bias for selfies and other types of portrait, confirming that the left cheek bias also presents within individuals’ selfie corpora.

  17. A physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations

    Directory of Open Access Journals (Sweden)

    Giattina Emily

    2011-09-01

    Full Text Available Abstract Background Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana, provides means to explore their genomic complexity. Results A genome-wide physical map of a rapid-cycling strain of B. oleracea was constructed by integrating high-information-content fingerprinting (HICF of Bacterial Artificial Chromosome (BAC clones with hybridization to sequence-tagged probes. Using 2907 contigs of two or more BACs, we performed several lines of comparative genomic analysis. Interspecific DNA synteny is much better preserved in euchromatin than heterochromatin, showing the qualitative difference in evolution of these respective genomic domains. About 67% of contigs can be aligned to the Arabidopsis genome, with 96.5% corresponding to euchromatic regions, and 3.5% (shown to contain repetitive sequences to pericentromeric regions. Overgo probe hybridization data showed that contigs aligned to Arabidopsis euchromatin contain ~80% of low-copy-number genes, while genes with high copy number are much more frequently associated with pericentromeric regions. We identified 39 interchromosomal breakpoints during the diversification of B. oleracea and Arabidopsis thaliana, a relatively high level of genomic change since their divergence. Comparison of the B. oleracea physical map with Arabidopsis and other available eudicot genomes showed appreciable 'shadowing' produced by more ancient polyploidies, resulting in a web of relatedness among contigs which increased genomic complexity. Conclusions A high-resolution genetically-anchored physical map sheds light on Brassica genome organization and advances positional cloning of specific genes, and may help to validate genome sequence assembly and alignment to chromosomes. All the physical mapping data is freely shared at a WebFPC site (http://lulu.pgml.uga.edu/fpc/WebAGCoL/brassica/WebFPC/; Temporarily password-protected: account

  18. Managing waiting times to predict no-shows and cancelations at a children’s hospital

    Directory of Open Access Journals (Sweden)

    Miguel Rodríguez-García

    2016-12-01

    Full Text Available Purpose: Since long waits in hospitals have been found to be related to high rates of no-shows and cancelations, managing waiting times should be considered as an important tool that hospitals can use to reduce missed appointments. The aim of this study is to analyze patients’ behavior in order to predict no-show and cancelation rates correlated to waiting times. Design/methodology/approach: This study is based on the data from a US children’s hospital, which includes all the appointments registered during one year of observation. We used the call-appointment interval to establish the wait time to get an appointment. Four different types of appointment-keeping behavior and two types of patients were distinguished: arrival, no-show, cancelation with no reschedule, and cancelation with reschedule; and new and established patients. Findings: Results confirmed a strong impact of long waiting times on patients’ appointment-keeping behavior, and the logarithmic regression was found as the best-fit function for the correlation between variables in all cases. The correlation analysis showed that new patients tend to miss appointments more often than established patients when the waiting time increases. It was also found that, depending on the patients’ appointment distribution, it might get more complicated for hospitals to reduce missed appointments as the waiting time is reduced. Originality/value: The methodology applied in our study, which combines the use of regression analysis and patients’ appointment distribution analysis, would help health care managers to understand the initial implications of long waiting times and to address improvement related to patient satisfaction and hospital performance.

  19. Analysis of competition performance in dressage and show jumping of Dutch Warmblood horses.

    Science.gov (United States)

    Rovere, G; Ducro, B J; van Arendonk, J A M; Norberg, E; Madsen, P

    2016-12-01

    Most Warmblood horse studbooks aim to improve the performance in dressage and show jumping. The Dutch Royal Warmblood Studbook (KWPN) includes the highest score achieved in competition by a horse to evaluate its genetic ability of performance. However, the records collected during competition are associated with some aspects that might affect the quality of the genetic evaluation based on these records. These aspects include the influence of rider, censoring and preselection of the data. The aim of this study was to quantify the impact of rider effect, censoring and preselection on the genetic analysis of competition data of dressage and show jumping of KWPN. Different models including rider effect were evaluated. To assess the impact of censoring, genetic parameters were estimated in data sets that differed in the degree of censoring. The effect of preselection on variance components was analysed by defining a binary trait (sport-status) depending on whether the horse has a competition record or not. This trait was included in a bivariate model with the competition trait and used all horses registered by KWPN since 1984. Results showed that performance in competition for dressage and show jumping is a heritable trait (h(2) ~ 0.11-0.13) and that it is important to account for the effect of rider in the genetic analysis. Censoring had a small effect on the genetic parameter for highest performance achieved by the horse. A moderate heritability obtained for sport-status indicates that preselection has a genetic basis, but the effect on genetic parameters was relatively small.

  20. Osteopathic manipulative treatment showed reduction of length of stay and costs in preterm infants

    Science.gov (United States)

    Lanaro, Diego; Ruffini, Nuria; Manzotti, Andrea; Lista, Gianluca

    2017-01-01

    Abstract Background: Osteopathic medicine is an emerging and complementary method used in neonatology. Methods: Outcomes were the mean difference in length of stay (LOS) and costs between osteopathy and alternative treatment group. A comprehensive literature search of (quasi)- randomized controlled trials (RCTs), was conducted from journal inception to May, 2015. Eligible studies must have treated preterm infants directly in the crib or bed and Osteopathic Manipulative Treatment (OMT) must have been performed by osteopaths. A rigorous Cochrane-like method was used for study screening and selection, risk of bias assessment and data reporting. Fixed effect meta-analysis was performed to synthesize data. Results: 5 trials enrolling 1306 infants met our inclusion criteria. Although the heterogeneity was moderate (I2 = 61%, P = 0.03), meta-analysis of all five studies showed that preterm infants treated with OMT had a significant reduction of LOS by 2.71 days (95% CI −3.99, −1.43; P < 0.001). Considering costs, meta-analysis showed reduction in the OMT group (−1,545.66€, −1,888.03€, −1,203.29€, P < 0.0001). All studies reported no adverse events associated to OMT. Subgroup analysis showed that the benefit of OMT is inversely associated to gestational age. Conclusions: The present systematic review showed the clinical effectiveness of OMT on the reduction of LOS and costs in a large population of preterm infants. PMID:28328840

  1. Environmental drivers of phototrophic biofilms in an Alpine show cave (SW-Italian Alps)

    Energy Technology Data Exchange (ETDEWEB)

    Piano, E., E-mail: elena.piano@unito.it [Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin (Italy); Bona, F.; Falasco, E. [Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin (Italy); La Morgia, V. [ISPRA, via Ca' Fornacetta, 9, 40064 Ozzano dell' Emilia (Italy); Badino, G. [Department of Physics, University of Turin, Via P. Giuria 1, 10125 Turin (Italy); Isaia, M. [Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Turin (Italy)

    2015-12-01

    The proliferation of lampenflora is a major threat for the conservation of show caves, since phototrophic organisms cause physical, chemical and aesthetic damage to speleothems. In this paper we examine the environmental factors influencing the presence and the growth of the three main photosynthetic groups composing phototrophic biofilms in the Bossea show cave (SW-Italian Alps). The presence and the primary production of cyanobacteria, diatoms and green algae were detected with BenthoTorch®, an instrument for in situ measurement of chlorophyll a concentration that has never been used before in caves. By means of different techniques of regression analysis, we highlighted the response of the three photosynthetic groups to different environmental factors. Illuminance proved to be the main factor influencing positively both the probability of the presence and the productivity of the three groups. The presence of seeping water on the substrate and the distance from the cave entrance proved to play an important role in determining patterns of colonization. By means of GIS techniques, we provide thematic maps of the cave, providing a representation of pattern of the density of the three examined photosynthetic groups within different areas of the cave. The same approach may apply to other show caves, aiming at providing suggestions for the cave management (i.e. cleaning of the cave walls and positioning of artificial lights) and reduce impact caused by tourism. - Highlights: • We used a PAM fluorimeter on autotrophic biofilms in a show cave for the first time. • We modelled the environmental factors influencing phototrophic biofilms. • Illuminance, moisture and distance from the entrance proved to be significant. • We produced thematic maps illustrating our results. • We provide suggestions for cave management.

  2. Results Evaluation in Reduction Rhinoplasty

    Directory of Open Access Journals (Sweden)

    Arima, Lisandra Megumi

    2011-01-01

    Full Text Available Introduction: Final results evaluation after rhinoplasty is a not a topic widely studied from the patient's viewpoint. Objective:Evaluate the satisfaction of the patients submitted to reduction rhinoplasty, from the questionnaire Rhinoplasty Outcomes Evaluation (ROE. Method: Longitudinal study, retrospective cut type, of the preoperative and postoperative satisfaction. The sample was composed by 28 patients who were submitted to rhinoplasty and answered the ROE questionnaire. Three variables were obtained: satisfaction note that the patient had with his/her image before the surgery; note of satisfaction with the current appearance; the difference of the average satisfaction notes between postoperative and preoperative approaches. Results: The postoperative note was higher than the preoperative in all patients. We noticed a difference between the average of the postoperative and preoperative of 48.3 (p75 considered to be an excellent outcome (67.9%. Conclusions: The ROE questionnaire is a helpful tool to show the satisfaction of the patient submitted to reduction rhinoplasty. About 92% of the patients submitted to reduction rhinoplasty consider the postoperative result to be good or excellent.

  3. LSND results and their implications

    Energy Technology Data Exchange (ETDEWEB)

    Caldwell, D.O. [California Univ., Santa Barbara, CA (United States). Dept. of Physics

    1996-11-01

    The combined 1993, 1994, and 1995 data from the LSND experiment shows a statistically compelling excess of events of the type expected for {nu}{sub {mu}} {yields}{nu}{sub e} neutrino oscillations. An electron between 36 and 60 MeV is identified by Cherenkov and scintillation light from {nu}{sub e}p{yields}e{sup +}n, and if a {gamma} is tightly constrained to be correlated with it from np{yields}d{gamma} (2.2 MeV), then 22 such events are observed, but only 4.6{+-}0.6 are expected from background. The probability that this is a fluctuation is <10{sup -7}. If subsequent analysis shows a similar effect from the independent channel {nu}{sub {mu}}{yields}{nu}{sub e}, then this would imply a neutrino mass difference which would contribute significantly to the dark matter of the universe. Explaining also the solar and atmospheric neutrino deficits results in a neutrino mass pattern which gives a cold + hot dark matter which fits the structure of the universe on all scales and requires a critical density universe and an universe age compatible with that of the oldest stars. This mass pattern involves a sterile neutrino, evidence for which may come from the need for it in producing heavy elements by supernovae and for blowing off the supernova mantle. (author) 3 figs., 18 refs.

  4. Grab That Mike: communicative issues in French Talk Show "Grab That Mike": questões comunicativas em um "Talk Show" Francês

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    Ludwina Van Son

    2004-12-01

    Full Text Available In this analysis we have chosen a recent French talk show to illustrate how communication is turned into some new kind of "ideology"nowadays: in other words, you have to communicate if you consider yourself a citizen of today's world. The main characteristic of issue-centered talk shows being the destabilization of the implicit rules and participation framework, we observe how the so-called democratic right to express ourselves is (misused by the talk show host to secure the dynamics of the show. In order to reveal the host's manipulations, we have examined the verbal interactions between host and guests on the following issues: topic choice, turn-taking mechanisms and identity construction of the talk show's guests. In the perspective that this kind of talk show presents itself as a public space where direct democracy can be exercised, the analysis of the discursive strategies of the talk show host reveals the impact of a mediatic participation framework.Para a presente análise escolhemos um "talk show" francês recente para ilustrar como a comunicação se transforma em um novo tipo de ideologia: em outras palavras, você deve se comunicar se você se considera um cidadão do mundo de hoje. Sendo a principal característica do talk show a desestabilização das regras implícitas e o framework de participação, observamos como o tal direito democrático de expressão é interpretado pelo apresentador para manter a dinâmica do programa. Para revelar suas manipulações, examinamos as interações verbais entre apresentador e convidados nos seguintes temas: escolha do tópico, mecanismos de tomada de turno e construção de identidade dos convidados. É nessa perspectiva que este tipo de programa se apresenta como um espaço público onde a democracia direta pode ser exercitada; a análise das estratégias discursivas do apresentador do talk show revela o impacto de um framework de participação mediada.

  5. Serum muscle-derived enzymes response during show jumping competition in horse

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    Anna Assenza

    2016-03-01

    Full Text Available Aim: The effect of two jumping competitions, performed in two consecutive weekends, on serum creatine phosphokinase (CPK, aspartate aminotransferase (AST, and lactate dehydrogenase (LDH, urea, creatinine (CREA concentrations were evaluated in 12 healthy jumper horses. Materials and Methods: Blood sampling was performed before the 1st day of competition (T0, at the end of each show (J1, J2, on the day after the competition (T1; the same sampling plan was followed during the second weekend (J3, J4 and T2. Results: One-way repeated measures analysis of variance showed an increase in CPK at J1 and J2 respect to T0 and at J3 and J4 respect to all other time points (p<0.05. LDH activity showed an increase at J2 respect to T0, at J3 respect to T0, J1, J2 and at J4 respect to all other time points (p<0.05. AST values increased at J1 and J2 respect to T0 (p<0.05. A significant increase of CREA was found at J3 respect to T0, T1 and J1 and at J4 respect to all other time points (p<0.05. A decrease in serum urea levels was found at J1 respect to T0, at J2 and J4 respect to T0 and T1; at T2 respect to T0 (p<0.05. A positive correlation between urea/CPK (p=0.0042, r2=0.030, LDH/CPK (p<0.0001, r2=0.535, CREA/LDH (p<0.0001, r2=0.263, CREA/CPK (p<0.0001, r2=0.496 was observed. Conclusion: Our results suggest that 5 days recovery period between the two consecutive competition weekends is insufficient to allow muscle recovery and avoid potential additional stress. The findings obtained in this study improve the knowledge about metabolic changes occurring in athlete horse during the competition to identify muscle alterations following show jumping competitions.

  6. Audit result and its users

    Directory of Open Access Journals (Sweden)

    Shalimova Nataliya S.

    2014-01-01

    Full Text Available The article identifies essence of the “audit result” and “users of audit result” notions and characteristics of the key audit results user. It shows that in order to give a wide characteristic of users it is expedient to unite all objects, which could be used (audit report, fact of refusal to conduct audit and information that is submitted to managers in the process of audit with the term “audit result” and classify it depending on the terms of submission by final and intermediate result. The article offers to define audit results user as a person, persons or category of persons for whom the auditor prepares the audit report and, in cases, envisaged by international standards of the audit and domestic legislative and regulatory acts, provides other additional information concerning audit issues. In order to identify the key audit results user the article distributes all audit tasks into two groups depending on possibilities of identification of users. The article proves that the key user should be identified especially in cases of a mandatory audit and this process should go in interconnection with the mechanism of allocation of a key user of financial reports. It offers to consider external users with direct financial interests, who cannot request economic subjects directly to provide information and who should rely on general financial reports and audit report when receiving significant portion of information they need, as the key user. The article makes proposals on specification of the categorical mechanism in the sphere of audit, which are the basis for audit quality assessment, identification of possibilities and conditions of appearance of the necessary and sufficient trust to the auditor opinion.

  7. Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes

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    Higashi Richard M

    2008-10-01

    Full Text Available Abstract Background The functional status of a cell is expressed in its metabolic activity. We have applied stable isotope tracing methods to determine the differences in metabolic pathways in proliferating Rhabdomysarcoma cells (Rh30 and human primary myocytes in culture. Uniformly 13C-labeled glucose was used as a source molecule to follow the incorporation of 13C into more than 40 marker metabolites using NMR and GC-MS. These include metabolites that report on the activity of glycolysis, Krebs' cycle, pentose phosphate pathway and pyrimidine biosynthesis. Results The Rh30 cells proliferated faster than the myocytes. Major differences in flux through glycolysis were evident from incorporation of label into secreted lactate, which accounts for a substantial fraction of the glucose carbon utilized by the cells. Krebs' cycle activity as determined by 13C isotopomer distributions in glutamate, aspartate, malate and pyrimidine rings was considerably higher in the cancer cells than in the primary myocytes. Large differences were also evident in de novo biosynthesis of riboses in the free nucleotide pools, as well as entry of glucose carbon into the pyrimidine rings in the free nucleotide pool. Specific labeling patterns in these metabolites show the increased importance of anaplerotic reactions in the cancer cells to maintain the high demand for anabolic and energy metabolism compared with the slower growing primary myocytes. Serum-stimulated Rh30 cells showed higher degrees of labeling than serum starved cells, but they retained their characteristic anabolic metabolism profile. The myocytes showed evidence of de novo synthesis of glycogen, which was absent in the Rh30 cells. Conclusion The specific 13C isotopomer patterns showed that the major difference between the transformed and the primary cells is the shift from energy and maintenance metabolism in the myocytes toward increased energy and anabolic metabolism for proliferation in the Rh30 cells

  8. Semantic Dementia Shows both Storage and Access Disorders of Semantic Memory

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    Yumi Takahashi

    2014-01-01

    Full Text Available Objective. Previous studies have shown that some patients with semantic dementia (SD have memory storage disorders, while others have access disorders. Here, we report three SD cases with both disorders. Methods. Ten pictures and ten words were prepared as visual stimuli to determine if the patients could correctly answer names and select pictures after hearing the names of items (Card Presentation Task, assessing memory storage disorder. In a second task, the viewing time was set at 20 or 300 msec (Momentary Presentation Task, evaluating memory access disorder using items for which correct answers were given in the first task. The results were compared with those for 6 patients with Alzheimer’s disease (AD. Results. The SD patients had lower scores than the AD group for both tasks, suggesting both storage and access disorders. The AD group had almost perfect scores on the Card Presentation Task but showed impairment on the Momentary Presentation Task, although to a lesser extent than the SD cases. Conclusions. These results suggest that SD patients have both storage and access disorders and have more severe access disorder than patients with AD.

  9. SC-535, a Novel Oral Multikinase Inhibitor, Showed Potent Antitumor Activity in Human Melanoma Models

    Directory of Open Access Journals (Sweden)

    Xin Chen

    2013-07-01

    Full Text Available Background: Melanoma is considered as one of the most aggressive and deadliest cancers and current targeted therapies of melanoma often suffer limited efficacy or drug resistance. Discovery of novel multikinase inhibitors as anti-melanoma drug candidates is still needed. Methods: In this investigation, we assessed the in vitro and in vivo anti-melanoma activities of SC-535, which is a novel small molecule multikinase inhibitor discovered by us recently. We analyzed inhibitory effects of SC-535 on various melanoma cell lines and human umbilical vascular endothelial cells (HUVEC in vitro. Tumor xenografts in athymic mice were used to examine the in vivo activity of SC-535. Results: SC-535 could efficiently inhibit vascular endothelial growth factor receptor (VEGFR 1/2/3, B-RAF, and C-RAF kinases. It showed significant antiangiogenic potencies both in vitro and in vivo and considerable anti-proliferative ability against several melanoma cell lines. Oral administration of SC-535 resulted in dose-dependent suppression of tumor growth in WM2664 and C32 xenograft mouse models. Studies of mechanisms of action indicated that SC-535 suppressed the tumor angiogenesis and induced G2/M phase cell cycle arrest in human melanoma cells. SC-535 possesses favorable pharmacokinetic properties. Conclusion: All of these results support SC-535 as a potential candidate for clinical studies in patients with melanoma.

  10. Experimental Evidence Shows the Importance of Behavioural Plasticity and Body Size under Competition in Waterfowl

    Science.gov (United States)

    Zhang, Yong; Prins, Herbert H. T.; Versluijs, Martijn; Wessels, Rick; Cao, Lei; de Boer, Willem Frederik

    2016-01-01

    When differently sized species feed on the same resources, interference competition may occur, which may negatively affect their food intake rate. It is expected that competition between species also alters behaviour and feeding patch selection. To assess these changes in behaviour and patch selection, we applied an experimental approach using captive birds of three differently sized Anatidae species: wigeon (Anas penelope) (~600 g), swan goose (Anser cygnoides) (~2700 g) and bean goose (Anser fabalis) (~3200 g). We quantified the functional response for each species and then recorded their behaviour and patch selection with and without potential competitors, using different species combinations. Our results showed that all three species acquired the highest nitrogen intake at relatively tall swards (6, 9 cm) when foraging in single species flocks in the functional response experiment. Goose species were offered foraging patches differing in sward height with and without competitors, and we tested for the effect of competition on foraging behaviour. The mean percentage of time spent feeding and being vigilant did not change under competition for all species. However, all species utilized strategies that increased their peck rate on patches across different sward heights, resulting in the same instantaneous and nitrogen intake rate. Our results suggest that variation in peck rate over different swards height permits Anatidae herbivores to compensate for the loss of intake under competition, illustrating the importance of behavioural plasticity in heterogeneous environments when competing with other species for resources. PMID:27727315

  11. Hanseniaspora uvarum from winemaking environments show spatial and temporal genetic clustering

    Directory of Open Access Journals (Sweden)

    Warren eAlbertin

    2016-01-01

    Full Text Available Hanseniaspora uvarum is one of the most abundant yeast species found on grapes and in grape must, at least before the onset of alcoholic fermentation which is usually performed by Saccharomyces species. The aim of this study was to characterise the genetic and phenotypic variability within the H. uvarum species. One hundred and fifteen strains isolated from winemaking environments in different geographical origins were analysed using 11 microsatellite markers and a subset of 47 strains were analysed by AFLP. H. uvarum isolates clustered mainly on the basis of their geographical localisation as revealed by microsatellites. In addition, a strong clustering based on year of isolation was evidenced, indicating that the genetic diversity of Hanseniaspora uvarum isolates was related to both spatial and temporal variations. Conversely, clustering analysis based on AFLP data provided a different picture with groups showing no particular characteristics, but provided higher strain discrimination. This result indicated that AFLP approaches are inadequate to establish the genetic relationship between individuals, but allowed good strain discrimination. At the phenotypic level, several extracellular enzymatic activities of enological relevance (pectinase, chitinase, protease, β-glucosidase were measured but showed low diversity. The impact of environmental factors of enological interest (temperature, anaerobia and copper addition on growth was also assessed and showed poor variation. Altogether, this work provided both new analytical tool (microsatellites and new insights into the genetic and phenotypic diversity of H. uvarum, a yeast species that has previously been identified as a potential candidate for co-inoculation in grape must, but whose intraspecific variability had never been fully assessed.

  12. Identified motor terminals in Drosophila larvae show distinct differences in morphology and physiology

    Science.gov (United States)

    Lnenicka, G. A.; Keshishian, H.

    2000-01-01

    In Drosophila, the type I motor terminals innervating the larval ventral longitudinal muscle fibers 6 and 7 have been the most popular preparation for combining synaptic studies with genetics. We have further characterized the normal morphological and physiological properties of these motor terminals and the influence of muscle size on terminal morphology. Using dye-injection and physiological techniques, we show that the two axons supplying these terminals have different innervation patterns: axon 1 innervates only muscle fibers 6 and 7, whereas axon 2 innervates all of the ventral longitudinal muscle fibers. This difference in innervation pattern allows the two axons to be reliably identified. The terminals formed by axons 1 and 2 on muscle fibers 6 and 7 have the same number of branches; however, axon 2 terminals are approximately 30% longer than axon 1 terminals, resulting in a corresponding greater number of boutons for axon 2. The axon 1 boutons are approximately 30% wider than the axon 2 boutons. The excitatory postsynaptic potential (EPSP) produced by axon 1 is generally smaller than that produced by axon 2, although the size distributions show considerable overlap. Consistent with vertebrate studies, there is a correlation between muscle fiber size and terminal size. For a single axon, terminal area and length, the number of terminal branches, and the number of boutons are all correlated with muscle fiber size, but bouton size is not. During prolonged repetitive stimulation, axon 2 motor terminals show synaptic depression, whereas axon 1 EPSPs facilitate. The response to repetitive stimulation appears to be similar at all motor terminals of an axon. Copyright 2000 John Wiley & Sons, Inc.

  13. Monocytes from HIV+ individuals show impaired cholesterol efflux and increased foam cell formation after transendothelial migration

    Science.gov (United States)

    MAISA, Anna; HEARPS, Anna C.; ANGELOVICH, Thomas A.; PEREIRA, Candida F.; ZHOU, Jingling; SHI, Margaret D.Y.; PALMER, Clovis S.; MULLER, William A.; CROWE, Suzanne M.; JAWOROWSKI, Anthony

    2016-01-01

    Design HIV+ individuals have an increased risk of atherosclerosis and cardiovascular disease which is independent of antiretroviral therapy and traditional risk factors. Monocytes play a central role in the development of atherosclerosis, and HIV-related chronic inflammation and monocyte activation may contribute to increased atherosclerosis, but the mechanisms are unknown. Methods Using an in vitro model of atherosclerotic plaque formation, we measured the transendothelial migration of purified monocytes from age-matched HIV+ and uninfected donors and examined their differentiation into foam cells. Cholesterol efflux and the expression of cholesterol metabolism genes were also assessed. Results Monocytes from HIV+ individuals showed increased foam cell formation compared to controls (18.9% vs 0% respectively, p=0.004) and serum from virologically suppressed HIV+ individuals potentiated foam cell formation by monocytes from both uninfected and HIV+ donors. Plasma TNF levels were increased in HIV+ vs control donors (5.9 vs 3.5 pg/ml, p=0.02) and foam cell formation was inhibited by blocking antibodies to TNF receptors, suggesting a direct effect on monocyte differentiation to foam cells. Monocytes from virologically suppressed HIV+ donors showed impaired cholesterol efflux and decreased expression of key genes regulating cholesterol metabolism, including the cholesterol transporter ABCA1 (p=0.02). Conclusions Monocytes from HIV+ individuals show impaired cholesterol efflux and are primed for foam cell formation following trans-endothelial migration. Factors present in HIV+ serum, including elevated TNF levels, further enhance foam cell formation. The pro-atherogenic phenotype of monocytes persists in virologically suppressed HIV+ individuals and may contribute mechanistically to increased atherosclerosis in this population. PMID:26244384

  14. Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia.

    Science.gov (United States)

    Shum, Angie M Y; Fung, David C Y; Corley, Susan M; McGill, Max C; Bentley, Nicholas L; Tan, Timothy C; Wilkins, Marc R; Polly, Patsie

    2015-12-01

    Cancer cachexia is a systemic, paraneoplastic syndrome seen in patients with advanced cancer. There is growing interest in the altered muscle pathophysiology experienced by cachectic patients. This study reports the microarray analysis of gene expression in cardiac and skeletal muscle in the colon 26 (C26) carcinoma mouse model of cancer cachexia. A total of 268 genes were found to be differentially expressed in cardiac muscle tissue, compared with nontumor-bearing controls. This was fewer than the 1,533 genes that changed in cachectic skeletal muscle. In addition to different numbers of genes changing, different cellular functions were seen to change in each tissue. The cachectic heart showed signs of inflammation, similar to cachectic skeletal muscle, but did not show the upregulation of ubiquitin-dependent protein catabolic processes or downregulation of genes involved in cellular energetics and muscle regeneration that characterizes skeletal muscle cachexia. Quantitative PCR was used to investigate a subset of inflammatory genes in the cardiac and skeletal muscle of independent cachectic samples; this revealed that B4galt1, C1s, Serpina3n, and Vsig4 were significantly upregulated in cardiac tissue, whereas C1s and Serpina3n were significantly upregulated in skeletal tissue. Our skeletal muscle microarray results were also compared with those from three published microarray studies and found to be consistent in terms of the genes differentially expressed and the functional processes affected. Our study highlights that skeletal and cardiac muscles are affected differently in the C26 mouse model of cachexia and that therapeutic strategies cannot assume that both muscle types will show a similar response.

  15. Toxocariasis Resulting in Seeming Allergy

    Directory of Open Access Journals (Sweden)

    Rosanna Qualizza

    2009-09-01

    Full Text Available Toxocara canis is an intestinal nematode affecting dogs and cats that causes human infestations by ingestion of embryonated eggs excreted in dogs' faeces. Humans are transport hosts, in whom the larvae do not develop to adult worms, but may migrate to various tissues and organs, and survive for several years, giving rise to several clinical symptoms, which include allergy-like presentations. We report three cases presenting as dermatitis, rhinitis, asthma, and conjunctivitis which were diagnosed and unsuccessfully treated as allergy. The correct diagnosis was established after detecting anti-Toxocara antibodies by Western blotting. All clinical symptoms showed improvement after starting treatment with mebendazole and subsequent courses of the antiparasitic drug resulted in full recovery. This suggests the possible role of Toxocara canis in inducing chronic symptoms of allergic type. This is particularly important for asthma, where it has been demonstrated that Toxocara canis infection causes allergic inflammation in the lungs associated with bronchial hyperreactivity. On the other hand, in our patients with asthma and with dermatitis the positive results from allergy tests were a confounding factor in delaying the correct diagnosis, which was finally obtained by the detection of antibodies to Toxocara canis.

  16. Results of Austin Moore replacement.

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    Jadhav A

    1996-04-01

    Full Text Available Forty cases of Austin Moore Replacement done for transcervical fractures of the femur in patients were reviewed after a period of 12 to 48 months postoperatively (mean 26 mth. 30 cases (75% had mild to severe pain of non-infective origin, starting as early as 6 months postoperatively. This was irrespective of the make, size or position (varus/valgus of the prosthesis. Though the Aufranc and Sweet clinical scoring was satisfactory in 65% cases, radiological evidence of complications like sinking, protrusion, etc. were seen in majority of the cases. Calcar resorption was seen in 34 cases (85% as early as 4 months postoperatively. Results of THR and bipolar replacement done for transcervical fractures in recent literature show 85% pain-free cases at 5 years. We feel that Austin Moore Replacement should be reserved for patients more than 65 years of age and those who are less active or debilitated because of other factors, because of increased acetabular wear with time in the younger individual. This is corroborated by unsatisfactory results in patients less than 65 years of age (p < 0.05.

  17. Why do high-redshift galaxies show diverse gas-phase metallicity gradients?

    CERN Document Server

    Ma, Xiangcheng; Feldmann, Robert; Torrey, Paul; Faucher-Giguere, Claude-Andre; Keres, Dusan

    2016-01-01

    Recent spatially resolved observations of galaxies at z=0.6-3 reveal that high-redshift galaxies show complex kinematics and a broad distribution of gas-phase metallicity gradients. To understand these results, we use a suite of high-resolution cosmological zoom-in simulations from the Feedback in Realistic Environments (FIRE) project, which include physically motivated models of the multi-phase ISM, star formation, and stellar feedback. Our simulations reproduce the observed diversity of kinematic properties and metallicity gradients, broadly consistent with observations at z=0-3. Strong negative metallicity gradients only appear in galaxies with a rotating disk, but not all rotationally supported galaxies have significant gradients. Strongly perturbed galaxies with little rotation always have flat gradients. The kinematic properties and metallicity gradient of a high-redshift galaxy can vary significantly on short time-scales, associated with starburst episodes. Feedback from a starburst can destroy the gas...

  18. Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.

    Science.gov (United States)

    2012-08-03

    Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. Here, The HD Consortium reports the generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls. Microarray profiling revealed CAG-repeat-expansion-associated gene expression patterns that distinguish patient lines from controls, and early onset versus late onset HD. Differentiated HD neural cells showed disease-associated changes in electrophysiology, metabolism, cell adhesion, and ultimately cell death for lines with both medium and longer CAG repeat expansions. The longer repeat lines were however the most vulnerable to cellular stressors and BDNF withdrawal, as assessed using a range of assays across consortium laboratories. The HD iPSC collection represents a unique and well-characterized resource to elucidate disease mechanisms in HD and provides a human stem cell platform for screening new candidate therapeutics.

  19. Web of Science: showing a bug today that can mislead scientific research output's prediction

    CERN Document Server

    Batista, Pablo Diniz; Fauth, Leduc Hermeto de Almeida; Brandão, Marcia de Oliveira Reis

    2016-01-01

    As it happened in all domains of human activities, economic issues and the increase of people working in scientific research have altered the way scientific production is evaluated so as the objectives of performing the evaluation. Introduced in 2005 by J. E. Hirsch as an indicator able to measure individual scientific output not only in terms of quantity, but also in terms of quality, h index has spread throughout the world. In 2007, Hirsch proposed its adoption also as the best to predict future scientific achievement and, consequently, a useful guide for investments in research and for institutions when hiring members for their scientific staff. Since then, several authors have also been using the Thomson ISI Web of Science database to develop their proposals for evaluating research output. Here we show that a subtle flaw in Web of Science can inflate the results of info collected, therefore compromising the exactness and, consequently, the effectiveness of Hirsch's proposal and its variations

  20. Antiparkinson drug--Mucuna pruriens shows antioxidant and metal chelating activity.

    Science.gov (United States)

    Dhanasekaran, Muralikrishnan; Tharakan, Binu; Manyam, Bala V

    2008-01-01

    Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease. The antioxidant activity of Mucuna pruriens was demonstrated by its ability to scavenge DPPH radicals, ABTS radicals and reactive oxygen species. Mucuna pruriens significantly inhibited the oxidation of lipids and deoxyribose sugar. Mucuna pruriens exhibited divalent iron chelating activity and did not show any genotoxic/mutagenic effect on the plasmid DNA. These results suggest that the neuroprotective and neurorestorative effect of Mucuna pruriens may be related to its antioxidant activity independent of the symptomatic effect. In addition, the drug appears to be therapeutically safe in the treatment of patients with Parkinson's disease.

  1. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

    DEFF Research Database (Denmark)

    Tort, F.; Bartkova, J.; Sehested, M.

    2006-01-01

    Loss of G(1)-S control and aberrations of the p16(Ink4a)-cyclin D1/cyclin-dependent kinase (CDK) 4(6)-pRb-E2F-cyclin E/CDK2 pathway are common in human cancer. Previous studies showed that oncogene-induced aberrant proliferation, such as on cyclin E overexpression, causes DNA damage and checkpoint...... culture models with differential defects of retinoblastoma pathway components, as overexpression of cyclin D1 or lack of p16(Ink4a), either alone or combined, did not elicit detectable DDR. In contrast, inactivation of pRb, the key component of the pathway, activated the DDR in cultured human or mouse...... cells, analogous to elevated cyclin E. These results highlight differential effect of diverse oncogenic events on driving the 'cancer cell cycles' and their ability to deregulate the replication-driving CDK2 kinase and to alarm the DDR as a potential anticancer barrier in accordance...

  2. Visual evoked potentials show strong positive association with intracranial pressure in patients with cryptococcal meningitis

    Directory of Open Access Journals (Sweden)

    Marcelo Adriano da Cunha Silva Vieira

    2015-04-01

    Full Text Available Objective : To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP in patients with cryptococcal meningitis. Method The sample included adults diagnosed with cryptococcal meningitis admitted at a reference hospital for infectious diseases. The patients were subjected to F-VEP tests shortly before lumbar puncture. The Pearson’s linear correlation coefficient was calculated and the linear regression analysis was performed. Results : Eighteen individuals were subjected to a total of 69 lumbar punctures preceded by F-VEP tests. At the first lumbar puncture performed in each patient, N2 latency exhibited a strong positive correlation with intracranial pressure (r = 0.83; CI = 0.60 - 0.94; p < 0.0001. The direction of this relationship was maintained in subsequent punctures. Conclusion : The intracranial pressure measured by spinal tap manometry showed strong positive association with the N2 latency F-VEP in patients with cryptococcal meningitis.

  3. New drug treatments show neuroprotective effects in Alzheimer’s and Parkinson’s diseases

    Institute of Scientific and Technical Information of China (English)

    Christian Hölscher

    2014-01-01

    Type 2 diabetes is a risk factor for Alzheimer’s disease and Parkinson’s disease. Insulin signaling in the brains of people with Alzheimer’s disease or Parkinson’s disease is impaired. Preclinical studies of growth factors showed impressive neuroprotective effects. In animal models of Alz-heimer’s disease and Parkinson’s disease, insulin, glia-derived neurotrophic factor, or analogues of the incretin glucagon-like peptide-1 prevented neurodegenerative processes and improved neuronal and synaptic functionality in Alzheimer’s disease and Parkinson’s disease. On the basis of these promising ifndings, several clinical trials are ongoing with the ifrst encouraging clinical results published. This gives hope for developing effective treatments for Alzheimer’s disease and Parkinson’s disease that are currently unavailable.

  4. Developmental reversals in risky decision making: intelligence agents show larger decision biases than college students.

    Science.gov (United States)

    Reyna, Valerie F; Chick, Christina F; Corbin, Jonathan C; Hsia, Andrew N

    2014-01-01

    Intelligence agents make risky decisions routinely, with serious consequences for national security. Although common sense and most theories imply that experienced intelligence professionals should be less prone to irrational inconsistencies than college students, we show the opposite. Moreover, the growth of experience-based intuition predicts this developmental reversal. We presented intelligence agents, college students, and postcollege adults with 30 risky-choice problems in gain and loss frames and then compared the three groups' decisions. The agents not only exhibited larger framing biases than the students, but also were more confident in their decisions. The postcollege adults (who were selected to be similar to the students) occupied an interesting middle ground, being generally as biased as the students (sometimes more biased) but less biased than the agents. An experimental manipulation testing an explanation for these effects, derived from fuzzy-trace theory, made the students look as biased as the agents. These results show that, although framing biases are irrational (because equivalent outcomes are treated differently), they are the ironical output of cognitively advanced mechanisms of meaning making.

  5. Arctic lakes show strong decadal trend in earlier spring ice-out

    Science.gov (United States)

    Šmejkalová, Tereza; Edwards, Mary E.; Dash, Jadunandan

    2016-12-01

    The timing of the seasonal freeze-thaw cycle of arctic lakes affects ecological processes and land-atmosphere energy fluxes. We carried out detailed ice-phenology mapping of arctic lakes, based on daily surface-reflectance time series for 2000-2013 from MODIS at 250 m spatial resolution. We used over 13,300 lakes, area >1 km2, in five study areas distributed evenly across the circumpolar Arctic — the first such phenological dataset. All areas showed significant trends towards an earlier break-up, stronger than previously reported. The mean shift in break-up start ranged from -0.10 days/year (Northern Europe) to -1.05 days/year (central Siberia); the shift in break-up end was between -0.14 and -0.72 days/year. Finally, we explored the effect of temperature on break-up timing and compared results among study areas. The 0 °C isotherm shows the strongest relationship (r = 0.56-0.81) in all study areas. If the trend in early break-up continues, rapidly changing ice phenology will likely generate significant, arctic-wide impacts.

  6. PCOS women show significantly higher homocysteine level, independent to glucose and E2 level

    Science.gov (United States)

    Eskandari, Zahra; Sadrkhanlou, Rajab-Ali; Nejati, Vahid; Tizro, Gholamreza

    2016-01-01

    Background: It is reasonable to think that some biochemical characteristics of follicular fluid (FF) surrounding the oocyte may play a critical role in determining the quality of oocyte and the subsequent potential needed to achieve fertilization and embryo development. Objective: This study was carried out to evaluate the levels of FF homocysteine (Hcy) in IVF candidate polycystic ovary syndrome (PCOS) women and any relationships with FF glucose and estradiol (E2) levels. Materials and Methods: In this case control study which was performed in Dr. Tizro Day Care and IVF Center 70 infertile patients were enrolled in two groups: comprising 35 PCOS and 35 non PCOS women. Long protocol was performed for all patients. FF Hcy, glucose and E2 levels were analyzed at the time of oocyte retrieval. Results: It was observed that FF Hcy level was significantly higher in PCOS patients compared with non PCOSs (p<0.01). Observations demonstrated that in PCOS group, the Hcy level increased independent to E2, glucose levels, BMI and age, while the PCOS group showed significantly higher BMI compared with non-PCOS group (p=0.03). However, no significant differences were revealed between groups for FF glucose and E2 levels. Conclusion: Present data showed that although FF glucose and E2 levels were constant in PCOS and non PCOS patients, but the FF Hcy levels in PCOS were significantly increased (p=0.01). PMID:27679823

  7. Gastric cancers of Western European and African patients show different patterns of genomic instability

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    Mulder Chris JJ

    2011-01-01

    Full Text Available Abstract Background Infection with H. pylori is important in the etiology of gastric cancer. Gastric cancer is infrequent in Africa, despite high frequencies of H. pylori infection, referred to as the African enigma. Variation in environmental and host factors influencing gastric cancer risk between different populations have been reported but little is known about the biological differences between gastric cancers from different geographic locations. We aim to study genomic instability patterns of gastric cancers obtained from patients from United Kingdom (UK and South Africa (SA, in an attempt to support the African enigma hypothesis at the biological level. Methods DNA was isolated from 67 gastric adenocarcinomas, 33 UK patients, 9 Caucasian SA patients and 25 native SA patients. Microsatellite instability and chromosomal instability were analyzed by PCR and microarray comparative genomic hybridization, respectively. Data was analyzed by supervised univariate and multivariate analyses as well as unsupervised hierarchical cluster analysis. Results Tumors from Caucasian and native SA patients showed significantly more microsatellite instable tumors (p Conclusions Gastric cancers from SA and UK patients show differences in genetic instability patterns, indicating possible different biological mechanisms in patients from different geographical origin. This is of future clinical relevance for stratification of gastric cancer therapy.

  8. Colorectal cancers with aneuploids show high CD133 expression and poor prognosis

    Institute of Scientific and Technical Information of China (English)

    Dongdong Yu; Yonghong Zhang; You Zou; Ming Tian; Deding Tao; Junbo Hu; Jianping Gong

    2010-01-01

    Objective:The aim of the study was to investigate the relationship of DNA ploidy status in colorectal cancers with patients' prognosis and also the relationship of DNA ploidy status with expression of the colorectal cancer stem cell marker CD133.Methods:The DNA ploidy status and CD133 expression in colorectal cancers were detected by flow cytometry.The clinicopathological characteristics and progression-free survival analysis of patients was evaluated based on the clinical data.Results:DNA ploidy pattern did not correlated with gender,age,lesion diameter,histological type,depth of tumor invasion,lymphatic invasion and Dukes stage.Only primary lesion cite showed significant correlation with DNA ploidy pattern,more aneuploids were observed in colonic cancer than rectal cancer,P < 0.05.The 2-year progression-free survival rate and total progression-free time in patients with aneuploids were lower than that with diploids,P < 0.05.Tumors contained aneuploids showed higher expression of CD133 than tumors of only diploids,P < 0.05.Conclusion:Tumor DNA ploidy status is a significant prognostic factor in patients with colorectal cancer and also associated with the existence of CD133 positive colorectal cancer stem cells.

  9. Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

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    Cotter Finbarr E

    2009-08-01

    Full Text Available Abstract Background Down syndrome (DS, caused by trisomy of human chromosome 21 (HSA21, is the most common genetic birth defect. Congenital heart defects (CHD are seen in 40% of DS children, and >50% of all atrioventricular canal defects in infancy are caused by trisomy 21, but the causative genes remain unknown. Results Here we show that aberrant adhesion and proliferation of DS cells can be reproduced using a transchromosomic model of DS (mouse fibroblasts bearing supernumerary HSA21. We also demonstrate a deacrease of cell migration in transchromosomic cells independently of their adhesion properties. We show that cell-autonomous proteome response to the presence of Collagen VI in extracellular matrix is strongly affected by trisomy 21. Conclusion This set of experiments establishes a new model system for genetic dissection of the specific HSA21 gene-overdose contributions to aberrant cell migration, adhesion, proliferation and specific proteome response to collagen VI, cellular phenotypes linked to the pathogenesis of CHD.

  10. SPF rabbits infected with rabbit hepatitis E virus isolate experimentally showing the chronicity of hepatitis.

    Science.gov (United States)

    Han, Jian; Lei, Yaxin; Liu, Lin; Liu, Peng; Xia, Junke; Zhang, Yulin; Zeng, Hang; Wang, Lin; Wang, Ling; Zhuang, Hui

    2014-01-01

    This study focused on investigating the pathogenesis seen in specific-pathogen-free (SPF) rabbits following infection with a homologous rabbit HEV isolate (CHN-BJ-rb14) and comparing it to that seen following infection with a heterologous swine genotype 4 HEV isolate (CHN-XJ-SW13). Three of the four animals inoculated with the homologous rabbit HEV became infected, exhibiting an intermittent viremia, obvious fluctuations of liver function biomarkers alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and persistent fecal virus shedding throughout the nine month study. In addition, liver histopathology showed both chronic inflammation and some degree of fibrosis. Both positive and negative-stranded HEV RNA and HEV antigen expression were detected in liver, brain, stomach, duodenum and kidney from the necropsied rabbits. Inflammation of extrahepatic tissue (duodenum and kidney) was also observed. Three of the four rabbits inoculated with the heterologous genotype 4 swine HEV also became infected, showing similar levels of anti-HEV antibody to that generated following infection with the homologous virus isolate. The duration of both viremia and fecal shedding of virus was however shorter following infection with the heterologous virus and there was no significant elevation of liver function biomarkers. These results suggest that rabbit HEV infection may cause more severe hepatitis and prolong the course of the disease, with a possible chronic trend of hepatitis in SPF rabbits.

  11. First-born siblings show better second language skills than later born siblings

    Directory of Open Access Journals (Sweden)

    Karin eKeller

    2015-06-01

    Full Text Available We examined the extent to which three sibling structure variables number of siblings, birth order and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children’s age, sex, nationality, number of children’s books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: The more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings.The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions.

  12. HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues.

    Science.gov (United States)

    Lamers, Susanna L; Gray, Rebecca R; Salemi, Marco; Huysentruyt, Leanne C; McGrath, Michael S

    2011-01-01

    Brain infection by the human immunodeficiency virus type 1 (HIV-1) has been investigated in many reports with a variety of conclusions concerning the time of entry and degree of viral compartmentalization. To address these diverse findings, we sequenced HIV-1 gp120 clones from a wide range of brain, peripheral and meningeal tissues from five patients who died from several HIV-1 associated disease pathologies. High-resolution phylogenetic analysis confirmed previous studies that showed a significant degree of compartmentalization in brain and peripheral tissue subpopulations. Some intermixing between the HIV-1 subpopulations was evident, especially in patients that died from pathologies other than HIV-associated dementia. Interestingly, the major tissue harboring virus from both the brain and peripheral tissues was the meninges. These results show that (1) HIV-1 is clearly capable of migrating out of the brain, (2) the meninges are the most likely primary transport tissues, and (3) infected brain macrophages comprise an important HIV reservoir during highly active antiretroviral therapy.

  13. The sex determination gene shows no founder effect in the giant honey bee, Apis dorsata.

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    Zhi Yong Liu

    Full Text Available BACKGROUND: All honey bee species (Apis spp share the same sex determination mechanism using the complementary sex determination (csd gene. Only individuals heterogeneous at the csd allele develop into females, and the homozygous develop into diploid males, which do not survive. The honeybees are therefore under selection pressure to generate new csd alleles. Previous studies have shown that the csd gene is under balancing selection. We hypothesize that due to the long separation from the mainland of Hainan Island, China, that the giant honey bees (Apis dorsata should show a founder effect for the csd gene, with many different alleles clustered together, and these would be absent on the mainland. METHODOLOGY/PRINCIPAL FINDINGS: We sampled A. dorsata workers from both Hainan and Guangxi Provinces and then cloned and sequenced region 3 of the csd gene and constructed phylogenetic trees. We failed to find any clustering of the csd alleles according to their geographical origin, i.e. the Hainan and Guangxi samples did not form separate clades. Further analysis by including previously published csd sequences also failed to show any clade-forming in both the Philippines and Malaysia. CONCLUSIONS/SIGNIFICANCE: Results from this study and those from previous studies did not support the expectations of a founder effect. We conclude that because of the extremely high mating frequency of A. dorsata queens, a founder effect does not apply in this species.

  14. Children with dyslexia show cortical hyperactivation in response to increasing literacy processing demands

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    Frøydis eMorken

    2014-12-01

    Full Text Available This fMRI study aimed to examine how differences in literacy processing demands may affect cortical activation patterns in 11- to 12-year-old children with dyslexia as compared to children with typical reading skills. 11 children with and 18 without dyslexia were assessed using a reading paradigm based on different stages of literacy development. In the analyses, six regions showed an interaction effect between group and condition in a factorial ANOVA. These regions were selected as regions of interest for further analyses. Overall, the dyslexia group showed cortical hyperactivation compared to the typical group. The difference between the groups tended to increase with increasing processing demands. Differences in cortical activation were not reflected in in-scanner reading performance. The six regions further grouped into three patterns, which are discussed in terms of processing demands, compensatory mechanisms, orthography and contextual facilitation. We conclude that the observed hyperactivation is chiefly a result of compensatory activity, modulated by other factors.

  15. Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors.

    Science.gov (United States)

    Gomez, J L; Luine, V N

    2014-01-17

    Exposure to daily life stressors is associated with increases in anxiety, depression, and overall negative affect. Alcohol or other psychoactive drugs are often used to alleviate stress effects. While females are more than twice as likely to develop mood disorders and are more susceptible to dependency than males, they are infrequently examined. In this study, female rats received no stress/no alcohol control (CON), alcohol alone (ALC), stress alone (STR), or stress plus alcohol (STR+ALC). Stress consisted of restraint for 6h/day/7days, and alcohol was administered immediately following restraint via gastric gavage at a dose of 2.0g/kg. Dependent measures included tests utilizing object recognition (OR), Y-maze, elevated plus maze (EPM), forced swim (FST), blood alcohol content, corticosterone levels, and body weights. ALC, STR+ALC, but not stress alone, impaired memory on OR. All treatments impaired spatial memory on the Y-maze. Anxiety was not affected on the EPM, but rats treated with alcohol or in combination with stress showed increased immobility on the FST, suggestive of alcohol-induced depression. Previously, we found alcohol reversed deleterious effects of stress on memory and mood in males, but current results show that females reacted negatively when the two treatments were combined. Thus, responses to alcohol, stress and their combination suggest that sex specific treatments are needed for stress-induced behavioral changes and that self-medicating with alcohol to cope with stress maybe deleterious in females.

  16. Breastfeeding Shows a Protective Trend toward Adolescents with Higher Abdominal Adiposity

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    Julien Rousseaux

    2014-10-01

    Full Text Available Objective: The question of whether breastfeeding has a protective effect against the development of overweight or obesity later in life remains controversial, especially during adolescence. The objective was to assess the relationship between breastfeeding and adolescents' body composition. Methods: The HELENA study is a cross-sectional study involving 3,528 adolescents from 10 European cities. The outcome measures were body weight and height, subscapular skinfolds as well as waist circumferences. Breastfeeding, smoking status, and parental socioeconomic status were assessed by self-administered questionnaires. Dietary intake was recorded using two 24-hour recall surveys. Two adjustment approaches were used: i covariance analysis adjusted for confounding factors (propensity score adjustment and ii multivariate quantile regression. Results: After adjustment, no significant associations were observed between breastfeeding and body composition parameters (BMI Z-score; sum of skinfolds; waist-to-height ratio. An adjusted quantile regression analysis showed a non-significant trend for a protective effect of breastfeeding toward the highest percentiles of adiposity in boys but not in girls. This is of particular interest with respect to the superiority of the waist-to-height ratio over waist circumference and BMI for detecting cardiometabolic risk factors. Conclusion: This first European study, including a large set of factors influencing adolescents' body composition, showed a non-significant trend toward a protective effect of breastfeeding on highest percentiles of adolescent's abdominal adiposity.

  17. Does it pay to delay? Flesh flies show adaptive plasticity in reproductive timing.

    Science.gov (United States)

    Wessels, Frank J; Kristal, Ross; Netter, Fleta; Hatle, John D; Hahn, Daniel A

    2011-02-01

    Life-history plasticity is widespread among organisms. However, an important question is whether it is adaptive. Most models for plasticity in life-history timing predict that animals, once they have reached the minimal nutritional threshold under poor conditions, will accelerate development or time to reproduction. Adaptive delays in reproduction are not common, especially in short-lived species. Examples of adaptive reproductive delays exist in mammalian populations experiencing strong interspecific (e.g., predation) and intraspecific (e.g., infanticide) competition. But are there other environmental factors that may trigger an adaptive delay in reproductive timing? We show that the short-lived flesh fly Sarcophaga crassipalpis will delay reproduction under nutrient-poor conditions, even though it has already met the minimal nutritional threshold for reproduction. We test whether this delay strategy is an adaptive response allowing the scavenger time to locate more resources by experimentally providing supplemental protein pulses (early, mid and late) throughout the reproductive delay period. Flies receiving additional protein produced more and larger eggs, demonstrating a benefit of the delay. In addition, by tracking the allocation of carbon from the pulses using stable isotopes, we show that flies receiving earlier pulses incorporated more carbon into eggs and somatic tissue than those given a later pulse. These results indicate that the reproductive delay in S. crassipalpis is consistent with adaptive post-threshold plasticity, a nutritionally linked reproductive strategy that has not been reported previously in an invertebrate species.

  18. First-born siblings show better second language skills than later born siblings.

    Science.gov (United States)

    Keller, Karin; Troesch, Larissa M; Grob, Alexander

    2015-01-01

    We examined the extent to which three sibling structure variables number of siblings, birth order, and presence of an older sibling at school age are linked to the second language skills of bilingual children. The research questions were tested using an ethnically heterogeneous sample of 1209 bilingual children with German as a second language. Controlling for children's age, sex, nationality, number of children's books at home, family language and parental German language skills, hierarchical regression analyses showed an inverse relationship between the number of siblings and second language skills: the more siblings a child had, the lower was his/her second language proficiency. This relationship was mediated by attendance in early education institutions. Moreover, first-born siblings showed better second language skills than later born siblings. The current study revealed that the resource dilution model, i.e., the decrease in resources for every additional sibling, holds for second language acquisition. Moreover, the results indicate that bilingual children from families with several children benefit from access to early education institutions.

  19. The three catalases in Deinococcus radiodurans: Only two show catalase activity.

    Science.gov (United States)

    Jeong, Sun-Wook; Jung, Jong-Hyun; Kim, Min-Kyu; Seo, Ho Seong; Lim, Heon-Man; Lim, Sangyong

    2016-01-15

    Deinococcus radiodurans, which is extremely resistant to ionizing radiation and oxidative stress, is known to have three catalases (DR1998, DRA0146, and DRA0259). In this study, to investigate the role of each catalase, we constructed catalase mutants (Δdr1998, ΔdrA0146, and ΔdrA0259) of D. radiodurans. Of the three mutants, Δdr1998 exhibited the greatest decrease in hydrogen peroxide (H2O2) resistance and the highest increase in intracellular reactive oxygen species (ROS) levels following H2O2 treatments, whereas ΔdrA0146 showed no change in its H2O2 resistance or ROS level. Catalase activity was not attenuated in ΔdrA0146, and none of the three bands detected in an in-gel catalase activity assay disappeared in ΔdrA0146. The purified His-tagged recombinant DRA0146 did not show catalase activity. In addition, the phylogenetic analysis of the deinococcal catalases revealed that the DR1998-type catalase is common in the genus Deinococcus, but the DRA0146-type catalase was found in only 4 of 23 Deinococcus species. Taken together, these results indicate that DR1998 plays a critical role in the anti-oxidative system of D. radiodurans by detoxifying H2O2, but DRA0146 does not have catalase activity and is not involved in the resistance to H2O2 stress.

  20. Tannic acid modified silver nanoparticles show antiviral activity in herpes simplex virus type 2 infection.

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    Piotr Orlowski

    Full Text Available The interaction between silver nanoparticles and herpesviruses is attracting great interest due to their antiviral activity and possibility to use as microbicides for oral and anogenital herpes. In this work, we demonstrate that tannic acid modified silver nanoparticles sized 13 nm, 33 nm and 46 nm are capable of reducing HSV-2 infectivity both in vitro and in vivo. The antiviral activity of tannic acid modified silver nanoparticles was size-related, required direct interaction and blocked virus attachment, penetration and further spread. All tested tannic acid modified silver nanoparticles reduced both infection and inflammatory reaction in the mouse model of HSV-2 infection when used at infection or for a post-infection treatment. Smaller-sized nanoparticles induced production of cytokines and chemokines important for anti-viral response. The corresponding control buffers with tannic acid showed inferior antiviral effects in vitro and were ineffective in blocking in vivo infection. Our results show that tannic acid modified silver nanoparticles are good candidates for microbicides used in treatment of herpesvirus infections.

  1. Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction.

    Science.gov (United States)

    Sawamura, Naoya; Wakabayashi, Satoru; Matsumoto, Kodai; Yamada, Haruka; Asahi, Toru

    2015-09-04

    Cereblon (CRBN) is encoded by a candidate gene for autosomal recessive nonsyndromic intellectual disability (ID). The nonsense mutation, R419X, causes deletion of 24 amino acids at the C-terminus of CRBN, leading to mild ID. Although abnormal CRBN function may be associated with ID disease onset, its cellular mechanism is still unclear. Here, we examine the role of CRBN in aggresome formation and cytoprotection. In the presence of a proteasome inhibitor, exogenous CRBN formed perinuclear inclusions and co-localized with aggresome markers. Endogenous CRBN also formed perinuclear inclusions under the same condition. Treatment with a microtubule destabilizer or an inhibitor of the E3 ubiquitin ligase activity of CRBN blocked formation of CRBN inclusions. Biochemical analysis showed CRBN containing inclusions were high-molecular weight, ubiquitin-positive. CRBN overexpression in cultured cells suppressed cell death induced by proteasome inhibitor. Furthermore, knockdown of endogenous CRBN in cultured cells increased cell death induced by proteasome inhibitor, compared with control cells. Our results show CRBN is recruited to aggresome and has functional roles in cytoprotection against ubiquitin-proteasome system impaired condition.

  2. Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury.

    Science.gov (United States)

    Vitor, Rute F; Mota-Filipe, Helder; Teixeira, Generosa; Borges, Carlos; Rodrigues, Ana Isabel; Teixeira, Adriano; Paulo, Alexandra

    2004-08-01

    Pterospartum tridentatum is a Leguminosae that grows spontaneously in Portugal. The flowers are used in popular medicine for the treatment of throat irritation conditions and in herbal mixtures for diabetes. Diabetic vascular complications are due, among other reasons, to increased oxidative stress and for that reason antioxidants are believed to be beneficial for the diabetic patient. The flower water extract of this herbal drug showed dose-dependent protective effect of cultured human endothelial cells against oxidative injury induced by H2O2, at concentrations > or =0.3 mg/ml. This water extract, after liquid-liquid and chromatographic fractionation afforded one new isoflavone (5,5'-dihydroxy-3'-metoxi-isoflavone-7-O-beta-glucoside) and three other known isoflavones (prunetin, genistin and sissotrin). The structural characterisation of isolated compounds was achieved by UV, NMR and MS analysis. The flavonol glycoside isoquercitrin was also identified in the extract by HPLC analysis. Isoquercitrin is one of the active antioxidant principles of the extract since it showed dose-dependent protective effect against oxidative injury at concentrations > or =0.3 mM. Isoflavones were inactive at the same concentrations. The results suggest that the water extract of this herbal drug may prevent or reduce the development of diabetic vascular complications.

  3. Salvianolic acid A shows selective cytotoxicity against multidrug-resistant MCF-7 breast cancer cells.

    Science.gov (United States)

    Wang, Xin; Wang, Chunyan; Zhang, Longjiang; Li, Yanjun; Wang, Shouju; Wang, Jiandong; Yuan, Caiyun; Niu, Jia; Wang, Chengsheng; Lu, Guangming

    2015-02-01

    Multidrug resistance (MDR) is a major cause for incurable breast cancer. Salvianolic acid A (SAA), the hydrophilic polyphenolic derivative of Salvia miltiorrhiza Bunge (Danshen/Red Sage), was examined for cytotoxicities to MDR MCF-7 human breast cancer cells and their parental counterparts. We have shown that SAA inhibited proliferation, caused cell cycle arrest at the S phase, and induced apoptosis dose dependently to the two kinds of cancer cells. However, the resistant cells were significantly susceptible to the inhibition of SAA compared with the parental cells. SAA increased the level of reactive oxygen species (ROS) by 6.2-fold in the resistant cells, whereas the level of SAA-induced ROS changed only by 1.6-fold in their parental counterparts. Thus, the data showed that the selective cytotoxicity resulted from the hypersensitivity of the resistant cells to the strongly elevated ROS by SAA. In addition, SAA-triggered apoptosis was associated with increased caspase-3 activity, disrupted mitochondrial membrane potential, downregulated Bcl-2 expression, and upregulated Bax expression in the resistant cells. Moreover, SAA downregulated the level of P-glycoprotein, which was overexpressed in the resistant cells. This indicated that SAA modulated MDR. Furthermore, SAA showed higher antitumor activity than did doxorubicin in xenografts established from the resistant cells. The present work raised a possibility that SAA might be considered a potential choice to overcome MDR for the selective susceptibility of the resistant breast cancer cells to SAA treatment.

  4. Kinetic assay shows that increasing red cell volume could be a treatment for sickle cell disease

    Science.gov (United States)

    Li, Quan; Henry, Eric R.; Hofrichter, James; Smith, Jeffrey F.; Cellmer, Troy; Dunkelberger, Emily B.; Metaferia, Belhu B.; Jones-Straehle, Stacy; Boutom, Sarah; Christoph, Garrott W.; Wakefield, Terri H.; Link, Mary E.; Staton, Dwayne; Vass, Erica R.; Miller, Jeffery L.; Hsieh, Matthew M.; Tisdale, John F.; Eaton, William A.

    2017-01-01

    Although it has been known for more than 60 years that the cause of sickle cell disease is polymerization of a hemoglobin mutant, hydroxyurea is the only drug approved for treatment by the US Food and Drug Administration. This drug, however, is only partially successful, and the discovery of additional drugs that inhibit fiber formation has been hampered by the lack of a sensitive and quantitative cellular assay. Here, we describe such a method in a 96-well plate format that is based on laser-induced polymerization in sickle trait cells and robust, automated image analysis to detect the precise time at which fibers distort (“sickle”) the cells. With this kinetic method, we show that small increases in cell volume to reduce the hemoglobin concentration can result in therapeutic increases in the delay time prior to fiber formation. We also show that, of the two drugs (AES103 and GBT440) in clinical trials that inhibit polymerization by increasing oxygen affinity, one of them (GBT440) also inhibits sickling in the absence of oxygen by two additional mechanisms. PMID:28096387

  5. Improvement of mount preparations in showing myenteric nerve plexus from intestines of mice

    Institute of Scientific and Technical Information of China (English)

    王红; 张远强; 孙岚; 王春杨; 尹岭

    2003-01-01

    Objective: The whole mount preparations of digestive tract is an effective experimental way to study the appearance and distribution of nerve plexus in digestive tract. Although myentric nerve plexus preparations technique was reported very early. But we have done experiment over and over during our research work in order to improve this traditional method and to meet the needs of our research work, we made some progresses in regular mount preparations after many experiments, which helped offer better situation in observing myentric nerve plexus. Methods: Five healthy male adult Kunming mice (20-30 g in weight) were used in this study. After intraperitoneal injection of muscle relaxant, with dislocation of cervical vertebra method, the abdominal cavity was exposed through abdominal median incision. After several steps of mount preparations the mucous layer and longitudinal muscle layer mount preparations with myentric nerve plexus were stripped under anatomical microscope. Immunohistochemical staining was also used in our study. Results: The mount preparation samples with myentric nerve plexus from intestines of mice showed positive SP immunoreaction. The positive cells were dark brown. Many of the cytons appeared circular and oval, while some appeared triangular or irregular. Conclusion: Our improved method is really a good method to show enteric nerve plexus. The method has many advantages and is particularly applied to small animals such as Kunming mice and BALB/c mice, weighing from 20 g to 30 g.

  6. Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players.

    Science.gov (United States)

    Gärtner, H; Minnerop, M; Pieperhoff, P; Schleicher, A; Zilles, K; Altenmüller, E; Amunts, K

    2013-01-01

    To what extent does musical practice change the structure of the brain? In order to understand how long-lasting musical training changes brain structure, 20 male right-handed, middle-aged professional musicians and 19 matched controls were investigated. Among the musicians, 13 were pianists or organists with intensive practice regimes. The others were either music teachers at schools or string instrumentalists, who had studied the piano at least as a subsidiary subject, and practiced less intensively. The study was based on T1-weighted MR images, which were analyzed using deformation-based morphometry. Cytoarchitectonic probabilistic maps of cortical areas and subcortical nuclei as well as myeloarchitectonic maps of fiber tracts were used as regions of interest to compare volume differences in the brains of musicians and controls. In addition, maps of voxel-wise volume differences were computed and analyzed. Musicians showed a significantly better symmetric motor performance as well as a greater capability of controlling hand independence than controls. Structural MRI-data revealed significant volumetric differences between the brains of keyboard players, who practiced intensively and controls in right sensorimotor areas and the corticospinal tract as well as in the entorhinal cortex and the left superior parietal lobule. Moreover, they showed also larger volumes in a comparable set of regions than the less intensively practicing musicians. The structural changes in the sensory and motor systems correspond well to the behavioral results, and can be interpreted in terms of plasticity as a result of intensive motor training. Areas of the superior parietal lobule and the entorhinal cortex might be enlarged in musicians due to their special skills in sight-playing and memorizing of scores. In conclusion, intensive and specific musical training seems to have an impact on brain structure, not only during the sensitive period of childhood but throughout life.

  7. A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response

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    Brian eGriffiths

    2012-10-01

    Full Text Available One function of glucocorticoids is to restore homeostasis after an acute stress response by providing negative feedback to stress circuits in the brain. Loss of this negative feedback leads to elevated physiological stress and may contribute to depression, anxiety and post-traumatic stress disorder. We investigated the early, developmental effects of glucocorticoid signaling deficits on stress physiology and related behaviors using a mutant zebrafish, grs357, with non-functional glucocorticoid receptors. These mutants are morphologically inconspicuous and adult-viable. A previous study of adult grs357 mutants showed loss of glucocorticoid-mediated negative feedback and elevated physiological and behavioral stress markers. Already at five days post-fertilization, mutant larvae had elevated whole body cortisol, increased expression of pro-opiomelanocortin (POMC, the precursor of adrenocorticotropic hormone (ACTH, and failed to show normal suppression of stress markers after dexamethasone treatment. Mutant larvae had larger auditory-evoked startle responses compared to wildtype sibling controls (grwt, despite having lower spontaneous activity levels. Fluoxetine (Prozac treatment in mutants decreased startle responding and increased spontaneous activity, making them behaviorally similar to wildtype. This result mirrors known effects of selective serotonin reuptake inhibitors (SSRIs in modifying glucocorticoid signaling and alleviating stress disorders in human patients. Our results suggest that larval grs357 zebrafish can be used to study behavioral, physiological and molecular aspects of stress disorders. Most importantly, interactions between glucocorticoid and serotonin signaling appear to be highly conserved among vertebrates, suggesting deep homologies at the neural circuit level and opening up new avenues for research into psychiatric conditions.

  8. Brain morphometry shows effects of long-term musical practice in middle-aged keyboard players

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    Hanna eGärtner

    2013-09-01

    Full Text Available To what extent does musical practice change the structure of the brain? In order to understand how long-lasting musical training changes brain structure, 20 male right-handed, middle-aged professional musicians and 19 matched controls were investigated. Among the musicians, 13 were pianists or organists with intensive practice regimes. The others were either music teachers at schools or string instrumentalists, who had studied the piano at least as a subsidiary subject, and practiced less intensively. The study was based on T1-weighted MR images, which were analyzed using Deformation Field Morphometry. Cytoarchitectonic probabilistic maps of cortical areas and subcortical nuclei as well as myeloarchitectonic maps of fiber tracts were used as regions of interest to compare volume differences in the brains of musicians and controls. In addition, maps of voxel-wise volume differences were computed and analyzed.Musicians showed a significantly better symmetric motor performance as well as a greater capability of controlling hand independence than controls. Structural MRI-data revealed significant volumetric differences between the brains of keyboard players, who practiced intensively and controls in right sensorimotor areas and the corticospinal tract as well as in the entorhinal cortex and the left superior parietal lobule. Moreover, they showed also larger volumes in a comparable set of regions than the less intensively practicing musicians. The structural changes in the sensory and motor systems correspond well to the behavioral results, and can be interpreted in terms of plasticity as a result of intensive motor training. Areas of the superior parietal lobule and the entorhinal cortex might be enlarged in musicians due to their special skills in sight-playing and memorizing of scores. In conclusion, intensive and specific musical training seems to have an impact on brain structure, not only during the sensitive period of childhood but throughout

  9. Psychoacoustic tinnitus loudness and tinnitus-related distress show different associations with oscillatory brain activity.

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    Tobias Balkenhol

    Full Text Available BACKGROUND: The phantom auditory perception of subjective tinnitus is associated with aberrant brain activity as evidenced by magneto- and electroencephalographic studies. We tested the hypotheses (1 that psychoacoustically measured tinnitus loudness is related to gamma oscillatory band power, and (2 that tinnitus loudness and tinnitus-related distress are related to distinct brain activity patterns as suggested by the distinction between loudness and distress experienced by tinnitus patients. Furthermore, we explored (3 how hearing impairment, minimum masking level, and (4 psychological comorbidities are related to spontaneous oscillatory brain activity in tinnitus patients. METHODS AND FINDINGS: Resting state oscillatory brain activity recorded electroencephalographically from 46 male tinnitus patients showed a positive correlation between gamma band oscillations and psychoacoustic tinnitus loudness determined with the reconstructed tinnitus sound, but not with the other psychoacoustic loudness measures that were used. Tinnitus-related distress did also correlate with delta band activity, but at electrode positions different from those associated with tinnitus loudness. Furthermore, highly distressed tinnitus patients exhibited a higher level of theta band activity. Moreover, mean hearing loss between 0.125 kHz and 16 kHz was associated with a decrease in gamma activity, whereas minimum masking levels correlated positively with delta band power. In contrast, psychological comorbidities did not express significant correlations with oscillatory brain activity. CONCLUSION: Different clinically relevant tinnitus characteristics show distinctive associations with spontaneous brain oscillatory power. Results support hypothesis (1, but exclusively for the tinnitus loudness derived from matching to the reconstructed tinnitus sound. This suggests to preferably use the reconstructed tinnitus spectrum to determine psychoacoustic tinnitus loudness

  10. Ipomoea aquatica Extract Shows Protective Action Against Thioacetamide-Induced Hepatotoxicity

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    A. Hamid A. Hadi

    2012-05-01

    Full Text Available In the Indian system of traditional medicine (Ayurveda it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD rats were orally fed with I. aquatica (250 and 500 mg/kg for two months along with administration of TAA (i.p injection 200 mg/kg three times a week for two months. The results showed that the treatment of I. aquatica significantly lowered the TAA-induced serum levels of hepatic enzyme markers (ALP, ALT, AST, protein, albumin, bilirubin and prothrombin time. The hepatic content of activities and expressions SOD and CAT that were reduced by TAA were brought back to control levels by the plant extract supplement. Meanwhile, the rise in MDA level in the TAA receiving groups also were significantly reduced by I. aquatica treatment. Histopathology of hepatic tissues by H&E and Masson trichrome stains displayed that I. aquatica has reduced the incidence of liver lesions, including hepatic cells cloudy swelling, infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by TAA in rats. Therefore, the results of this study show that the protective effect of I. aquatica in TAA-induced liver damage might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Moreover, it confirms a scientific basis for the traditional use of I. aquatica for the treatment of liver disorders.

  11. Ipomoea aquatica extract shows protective action against thioacetamide-induced hepatotoxicity.

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    Alkiyumi, Salim Said; Abdullah, Mahmood Ameen; Alrashdi, Ahmed Salim; Salama, Suzy Munir; Abdelwahab, Siddig Ibrahim; Hadi, A Hamid A

    2012-05-22

    In the Indian system of traditional medicine (Ayurveda) it is recommended to consume Ipomoea aquatica to mitigate disorders like jaundice. In this study, the protective effects of ethanol extract of I. aquatica against liver damage were evaluated in thioacetamide (TAA)-induced chronic hepatotoxicity in rats. There was no sign of toxicity in the acute toxicity study, in which Sprague-Dawley (SD) rats were orally fed with I. aquatica (250 and 500 mg/kg) for two months along with administration of TAA (i.p injection 200 mg/kg three times a week for two months). The results showed that the treatment of I. aquatica significantly lowered the TAA-induced serum levels of hepatic enzyme markers (ALP, ALT, AST, protein, albumin, bilirubin and prothrombin time). The hepatic content of activities and expressions SOD and CAT that were reduced by TAA were brought back to control levels by the plant extract supplement. Meanwhile, the rise in MDA level in the TAA receiving groups also were significantly reduced by I. aquatica treatment. Histopathology of hepatic tissues by H&E and Masson trichrome stains displayed that I. aquatica has reduced the incidence of liver lesions, including hepatic cells cloudy swelling, infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by TAA in rats. Therefore, the results of this study show that the protective effect of I. aquatica in TAA-induced liver damage might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Moreover, it confirms a scientific basis for the traditional use of I. aquatica for the treatment of liver disorders.

  12. Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity

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    Vivier Melané A

    2008-07-01

    Full Text Available Abstract Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between different tissue layers within plant organs. The encoding genes could also be upregulated by abiotic and biotic stimuli during active defense processes. The peptides display a broad spectrum of antimicrobial activities. Their potent anti-pathogenic characteristics have ensured that they are promising targets in the medical and agricultural biotechnology sectors. Results A berry specific cDNA sequence designated Vv-AMP1, Vitis vinifera antimicrobial peptide 1, was isolated from Vitis vinifera. Vv-AMP1 encodes for a 77 amino acid peptide that shows sequence homology to the family of plant defensins. Vv-AMP1 is expressed in a tissue specific, developmentally regulated manner, being only expressed in berry tissue at the onset of berry ripening and onwards. Treatment of leaf and berry tissue with biotic or abiotic factors did not lead to increased expression of Vv-AMP1 under the conditions tested. The predicted signal peptide of Vv-AMP1, fused to the green fluorescent protein (GFP, showed that the signal peptide allowed accumulation of its product in the apoplast. Vv-AMP1 peptide, produced in Escherichia coli, had a molecular mass of 5.495 kDa as determined by mass spectrometry. Recombinant Vv-AMP1 was extremely heat-stable and showed strong antifungal activity against a broad spectrum of plant pathogenic fungi, with very high levels of activity against the wilting disease causing pathogens Fusarium oxysporum and Verticillium dahliae. The Vv-AMP1 peptide did not induce morphological changes on the treated fungal hyphae, but instead strongly inhibited hyphal elongation. A propidium iodide uptake assay suggested that the inhibitory activity of Vv-AMP1 might be associated with altering the membrane

  13. Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy.

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    de Munck, Estefanía; Palomo, Valle; Muñoz-Sáez, Emma; Perez, Daniel I; Gómez-Miguel, Begoña; Solas, M Teresa; Gil, Carmen; Martínez, Ana; Arahuetes, Rosa M

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. In the present work, the neuroprotective role of VP2.51, a small heterocyclic GSK-3 inhibitor, is analysed in this novel murine model together with the analysis of autophagy. VP2.51 daily administration for two weeks, starting the first day after L-BMAA treatment, leads to total recovery of neurological symptoms and prevents the activation of autophagic processes in rats. These results show that the L-BMAA murine model can be used to test the efficacy of new drugs. In addition, the results confirm the therapeutic potential of GSK-3 inhibitors, and specially VP2.51, for the disease-modifying future treatment of motor neuron disorders like ALS.

  14. HFE H63D mutation frequency shows an increase in Turkish women with breast cancer

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    Guler Emine

    2006-02-01

    Full Text Available Abstract Background The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls. Methods Archived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP. Results All subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176 in the breast cancer patients, and 14% (28/200 in the healthy volunteers. Statistical analysis of cases with HFE H63D phenotype showed significant difference between breast cancer and healthy volunteers (P = 0.02. Conclusion Our results suggest that HFE H63D mutation frequencies were increased in the breast cancer patients in comparison to those in the general population. Also, odds ratios (odds ratio = 2.05 computed in this study suggest that H63D has a positive association with breast cancer.

  15. Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys.

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    Arita, Minetaro; Shimizu, Hiroyuki; Nagata, Noriyo; Ami, Yasushi; Suzaki, Yuriko; Sata, Tetsutaro; Iwasaki, Takuya; Miyamura, Tatsuo

    2005-05-01

    Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease and is sometimes associated with serious neurological disorders. In this study, an attempt was made to identify molecular determinants of EV71 attenuation of neurovirulence in a monkey infection model. An infectious cDNA clone of the virulent strain of EV71 prototype BrCr was constructed; temperature-sensitive (ts) mutations of an attenuated strain of EV71 or of poliovirus (PV) Sabin vaccine strains were then introduced into the infectious clone. In vitro and in vivo phenotypes of the parental and mutant viruses were analysed in cultured cells and in cynomolgus monkeys, respectively. Mutations in 3D polymerase (3D(pol)) and in the 3' non-translated region (NTR), corresponding to ts determinants of Sabin 1, conferred distinct temperature sensitivity to EV71. An EV71 mutant [EV71(S1-3')] carrying mutations in the 5' NTR, 3D(pol) and in the 3' NTR showed attenuated neurovirulence, resulting in limited spread of virus in the central nervous system of monkeys. These results indicate that EV71 and PV1 share common genetic determinants of neurovirulence in monkeys, despite the distinct properties in their original pathogenesis.

  16. Small GSK-3 Inhibitor Shows Efficacy in a Motor Neuron Disease Murine Model Modulating Autophagy

    Science.gov (United States)

    de Munck, Estefanía; Palomo, Valle; Muñoz-Sáez, Emma; Perez, Daniel I.; Gómez-Miguel, Begoña; Solas, M. Teresa; Gil, Carmen; Martínez, Ana; Arahuetes, Rosa M.

    2016-01-01

    Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. In the present work, the neuroprotective role of VP2.51, a small heterocyclic GSK-3 inhibitor, is analysed in this novel murine model together with the analysis of autophagy. VP2.51 daily administration for two weeks, starting the first day after L-BMAA treatment, leads to total recovery of neurological symptoms and prevents the activation of autophagic processes in rats. These results show that the L-BMAA murine model can be used to test the efficacy of new drugs. In addition, the results confirm the therapeutic potential of GSK-3 inhibitors, and specially VP2.51, for the disease-modifying future treatment of motor neuron disorders like ALS. PMID:27631495

  17. Identification and Characterisation CRN Effectors in Phytophthora capsici Shows Modularity and Functional Diversity

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    Stam, Remco; Jupe, Julietta; Howden, Andrew J. M.; Morris, Jenny A.; Boevink, Petra C.; Hedley, Pete E.; Huitema, Edgar

    2013-01-01

    Phytophthora species secrete a large array of effectors during infection of their host plants. The Crinkler (CRN) gene family encodes a ubiquitous but understudied class of effectors with possible but as of yet unknown roles in infection. To appreciate CRN effector function in Phytophthora, we devised a simple Crn gene identification and annotation pipeline to improve effector prediction rates. We predicted 84 full-length CRN coding genes and assessed CRN effector domain diversity in sequenced Oomycete genomes. These analyses revealed evidence of CRN domain innovation in Phytophthora and expansion in the Peronosporales. We performed gene expression analyses to validate and define two classes of CRN effectors, each possibly contributing to infection at different stages. CRN localisation studies revealed that P. capsici CRN effector domains target the nucleus and accumulate in specific sub-nuclear compartments. Phenotypic analyses showed that few CRN domains induce necrosis when expressed in planta and that one cell death inducing effector, enhances P. capsici virulence on Nicotiana benthamiana. These results suggest that the CRN protein family form an important class of intracellular effectors that target the host nucleus during infection. These results combined with domain expansion in hemi-biotrophic and necrotrophic pathogens, suggests specific contributions to pathogen lifestyles. This work will bolster CRN identification efforts in other sequenced oomycete species and set the stage for future functional studies towards understanding CRN effector functions. PMID:23536880

  18. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model

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    Jahnke Vanessa E

    2012-08-01

    Full Text Available Abstract Background Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiation; enhancing mitochondrial activity with exercise mimetics (AMPK and PPAR-delta agonists increases muscle function and inhibits muscle wasting in healthy mice. We therefore asked whether metabolic remodeling agents that increase mitochondrial activity would improve muscle function in mdx mice. Methods Twelve-week-old mdx mice were treated with two different metabolic remodeling agents (GW501516 and AICAR, separately or in combination, for 4 weeks. Extensive systematic behavioral, functional, histological, biochemical, and molecular tests were conducted to assess the drug(s' effects. Results We found a gain in body and muscle weight in all treated mice. Histologic examination showed a decrease in muscle inflammation and in the number of fibers with central nuclei and an increase in fibers with peripheral nuclei, with significantly fewer activated satellite cells and regenerating fibers. Together with an inhibition of FoXO1 signaling, these results indicated that the treatments reduced ongoing muscle damage. Conclusions The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient mdx mice.

  19. Modified oleic cottonseeds show altered content, composition and tissue-specific distribution of triacylglycerol molecular species.

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    Horn, Patrick J; Sturtevant, Drew; Chapman, Kent D

    2014-01-01

    Targeted increases in monounsaturated (oleic acid) fatty acid content of refined cottonseed oil could support improved human nutrition and cardiovascular health. Genetic modifications of cottonseed fatty acid composition have been accomplished using several different molecular strategies. Modification of oleic acid content in cottonseed embryos using a dominant-negative protein approach, while successful in effecting change in the desired fatty acid composition, resulted in reduced oil content and seed viability. Here these changes in fatty acid composition were associated with changes in dominant molecular species of triacylglycerols (TAGs) and their spatial distributions within embryo tissues. A combination of mass spectrometry (MS)-based lipidomics approaches, including MS imaging of seed cryo-sections, revealed that cotton embryos expressing a non-functional allele of a Brassica napus delta-12 desaturase showed altered accumulation of TAG species, especially within cotyledonary tissues. While lipid analysis of seed extracts could demonstrate detailed quantitative changes in TAG species in transgenics, the spatial contribution of metabolite compartmentation could only be visualized by MS imaging. Our results suggest tissue-specific differences in TAG biosynthetic pathways within cotton embryos, and indicate the importance of considering the location of metabolites in tissues in addition to their identification and quantification when developing a detailed view of cellular metabolism.

  20. Adolescents with Mild Stunting Show Alterations in Glucose and Insulin Metabolism

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    Carla Danusa da Luz Santos

    2010-01-01

    Full Text Available Purpose. To evaluate glucose and insulin profiles in adolescents with mild stunting and overweight in order to assess the possibility of increased predisposition to diabetes. Subjects and Methods. The study population consisted of 66 pubertal adolescents classified as mildly stunted (height-for-age z scores ≥−2 and <−1 or of normal stature, as well as overweight (body mass index ≥85th percentile or normal weight. Beta-cell function and insulin resistance were evaluated according to the homeostasis model assessment (HOMA. Results. In the group with mild stunting, glucose, insulin, and HOMA-IR levels were significantly higher in overweight adolescents compared with those of normal weight, whereas HOMA-B levels were significantly lower. Adolescents with mild stunting showed significantly higher accumulations of body and abdominal fat than their normal stature counterparts. Conclusions. The presence of mild stunting was associated with higher levels of glucose and insulin, diminished function of beta cells, and increased insulin resistance. These results reinforce the need for intervention in adolescents with mild stunting.