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Sample records for upper sco ob

  1. New Results on the Nearest OB Association: Sco-Cen (Sco OB2)

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    Mamajek, Eric E.

    2013-01-01

    The Scorpius-Centaurus OB association (Sco OB2) is the nearest site of recent massive star formation to the Sun. The primary stellar groups in the Sco-Cen complex (including OB subgroups Upper Sco, Upper Cen Lup, and Lower Cen Cru, the neighboring molecular cloud complexes Lup, Cha, CrA, Oph, and dispersed young groups Eta Cha, Epsilon Cha, TW Hya, and Beta Pic) have been participants in a complex episode of stellar birth (and some stellar death) over the past ~20 Myr. Here I summarize some recent results on the Sco-Cen complex from the U. Rochester group: (1) isochronal analysis of the HR diagram positions for >1 Msun stars in the Upper Scorpius subgroup shows it to be twice as old as previously thought (11 Myr vs. 5 Myr), (2) analysis of high resolution optical echelle spectra show that the subgroups are approximately solar in composition, (3) surveys for lower mass members are showing that the complex shows more substructure than previously recognized, including at least one new subgroup ("Lower Sco"), and the velocity and age data for the nearest OB subgroup Lower Cen Cru argue for a bifurcation into a younger 10 Myr) southern part ("Crux") and an older 20 Myr) northern part ("Lower Centaurus"), (4) an eclipsing, multi-ring dust disk system was serendipitously discovered in the SuperWASP and ASAS light curve for the newly discovered K5-type Sco-Cen member 1SWASP J140747.93-394542.6. With regard to some recent results by other investigators, we find that (1) attempts by some authors to subsume the Sco-Cen subgroups into a single sample of a single age are unnecessarily mixing samples with a wide range in ages, and (2) I have been unable to replicate the expansion age determinations claimed by some investigators for the TW Hya and Beta Pic groups (both purported to have expansion ages of 8 and 12 Myr, respectively), which have been used by some investigators to independently age-date the Sco-Cen subgroups. We acknowledge support from NSF grant AST-1008908 and the

  2. The OB run-away stars from Sco-Cen and Orion reviewed

    International Nuclear Information System (INIS)

    Blaauw, A.

    1989-01-01

    The author studies the past paths of the run-away star Zeta Oph from the OB association Sco-Cen, and of the run-away stars AE Aur, Mu Col and 53 Ari from the OB association Ori OB1, in connection with the question of the origin of these high velocities. Should the binary-hypothesis be adhered to (supernova explosion of one of the components) or, perhaps, dynamical evolution in young, dense clusters offer a clue to this phenomenon? It is shown that the latter hypothesis is very unlikely to apply to Zeta Oph. For the run-away stars from Orion conclusive evidence may well be obtained in the course of the next decade, from improved accuracy of the proper motions

  3. An ALMA continuum survey of circumstellar disks in the upper Scorpius OB association

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    Carpenter, John M.; Ricci, Luca; Isella, Andrea [Department of Astronomy, California Institute of Technology, MC 249-17, Pasadena, CA 91125 (United States)

    2014-05-20

    We present ALMA 880 μm continuum observations of 20 K- and M-type stars in the Upper Scorpius OB association (Upper Sco) that are surrounded by protoplanetary disks. These data are used to measure the dust content in disks around low-mass stars (0.1-1.6 M {sub ☉}) at a stellar age of 5-11 Myr. Thirteen sources were detected in the 880 μm dust continuum at ≥3σ with inferred dust masses between 0.3 and 52 M {sub ⊕}. The dust masses tend to be higher around the more massive stars, but the significance is marginal in that the probability of no correlation is p ≈ 0.03. The evolution in the dust content in disks was assessed by comparing the Upper Sco observations with published continuum measurements of disks around ∼1-2 Myr stars in the Class II stage in the Taurus molecular cloud. While the dust masses in the Upper Sco disks are on average lower than in Taurus, any difference in the dust mass distributions is significant at less than 3σ. For stellar masses between 0.49 M {sub ☉} and 1.6 M {sub ☉}, the mean dust mass in disks is lower in Upper Sco relative to Taurus by Δlog M {sub dust} = 0.44 ± 0.26.

  4. Measurement of Circumstellar Disk Sizes in the Upper Scorpius OB Association with ALMA

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    Barenfeld, Scott A.; Carpenter, John M.; Sargent, Anneila I.; Isella, Andrea; Ricci, Luca

    2017-12-01

    We present detailed modeling of the spatial distributions of gas and dust in 57 circumstellar disks in the Upper Scorpius OB Association observed with ALMA at submillimeter wavelengths. We fit power-law models to the dust surface density and CO J = 3–2 surface brightness to measure the radial extent of dust and gas in these disks. We found that these disks are extremely compact: the 25 highest signal-to-noise disks have a median dust outer radius of 21 au, assuming an {R}-1 dust surface density profile. Our lack of CO detections in the majority of our sample is consistent with these small disk sizes assuming the dust and CO share the same spatial distribution. Of seven disks in our sample with well-constrained dust and CO radii, four appear to be more extended in CO, although this may simply be due to the higher optical depth of the CO. Comparison of the Upper Sco results with recent analyses of disks in Taurus, Ophiuchus, and Lupus suggests that the dust disks in Upper Sco may be approximately three times smaller in size than their younger counterparts, although we caution that a more uniform analysis of the data across all regions is needed. We discuss the implications of these results for disk evolution.

  5. Age Spreads and the Temperature Dependence of Age Estimates in Upper Sco

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    Fang Qiliang; Herczeg, Gregory J. [Kavli Institute for Astronomy and Astrophysics, Peking University, Yiheyuan Lu 5, Haidian Qu, 100871 Beijing (China); Rizzuto, Aaron [Department of Astronomy, University of Texas, 2515 Speedway, Stop C1400, Austin, TX 78712 (United States)

    2017-06-20

    Past estimates for the age of the Upper Sco Association are typically 11–13 Myr for intermediate-mass stars and 4–5 Myr for low-mass stars. In this study, we simulate populations of young stars to investigate whether this apparent dependence of estimated age on spectral type may be explained by the star formation history of the association. Solar and intermediate mass stars begin their pre-main sequence evolution on the Hayashi track, with fully convective interiors and cool photospheres. Intermediate-mass stars quickly heat up and transition onto the radiative Henyey track. As a consequence, for clusters in which star formation occurs on a timescale similar to that of the transition from a convective to a radiative interior, discrepancies in ages will arise when ages are calculated as a function of temperature instead of mass. Simple simulations of a cluster with constant star formation over several Myr may explain about half of the difference in inferred ages versus photospheric temperature; speculative constructions that consist of a constant star formation followed by a large supernova-driven burst could fully explain the differences, including those between F and G stars where evolutionary tracks may be more accurate. The age spreads of low-mass stars predicted from these prescriptions for star formation are consistent with the observed luminosity spread of Upper Sco. The conclusion that a lengthy star formation history will yield a temperature dependence in ages is expected from the basic physics of pre-main sequence evolution, and is qualitatively robust to the large uncertainties in pre-main sequence evolutionary models.

  6. New Parallaxes for the Upper Scorpius OB Association

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    Donaldson, J. K.; Weinberger, A. J.; Gagné, J.; Boss, A. P.; Keiser, S. A.

    2017-11-01

    Upper Scorpius is a subgroup of the nearest OB association, Scorpius-Centaurus. Its young age makes it an important association to study star and planet formation. We present parallaxes to 52 low-mass stars in Upper Scorpius, 28 of which have full kinematics. We measure ages of the individual stars by combining our measured parallaxes with pre-main-sequence evolutionary tracks. We find a significant difference in the ages of stars with and without circumstellar disks. The stars without disks have a mean age of 4.9 ± 0.8 Myr and those with disks have an older mean age of 8.2 ± 0.9 Myr. This somewhat counterintuitive result suggests that evolutionary effects in young stars can dominate their apparent ages. We also attempt to use the 28 stars with full kinematics (I.e., proper motion, radial velocity (RV), and parallax) to trace the stars back in time to their original birthplace to obtain a trackback age. As expected, given the large measurement uncertainties on available RV measurements, we find that measurement uncertainties alone cause the group to diverge after a few Myr.

  7. A REVISED AGE FOR UPPER SCORPIUS AND THE STAR FORMATION HISTORY AMONG THE F-TYPE MEMBERS OF THE SCORPIUS-CENTAURUS OB ASSOCIATION

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    Pecaut, Mark J.; Mamajek, Eric E.; Bubar, Eric J. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627-0171 (United States)

    2012-02-20

    We present an analysis of the ages and star formation history of the F-type stars in the Upper Scorpius (US), Upper Centaurus-Lupus (UCL), and Lower Centaurus-Crux (LCC) subgroups of Scorpius-Centaurus (Sco-Cen), the nearest OB association. Our parent sample is the kinematically selected Hipparcos sample of de Zeeuw et al., restricted to the 138 F-type members. We have obtained classification-resolution optical spectra and have also determined the spectroscopic accretion disk fraction. With Hipparcos and 2MASS photometry, we estimate the reddening and extinction for each star and place the candidate members on a theoretical H-R diagram. For each subgroup we construct empirical isochrones and compare to published evolutionary tracks. We find that (1) our empirical isochrones are consistent with the previously published age-rank of the Sco-Cen subgroups; (2) subgroups LCC and UCL appear to reach the main-sequence turn-on at spectral types {approx}F4 and {approx}F2, respectively. An analysis of the A-type stars shows US reaching the main sequence at about spectral type {approx}A3. (3) The median ages for the pre-main-sequence members of UCL and LCC are 16 Myr and 17 Myr, respectively, in agreement with previous studies, however we find that (4) Upper Sco is much older than previously thought. The luminosities of the F-type stars in US are typically a factor of {approx}2.5 less luminous than predicted for a 5 Myr old population for four sets of evolutionary tracks. We re-examine the evolutionary state and isochronal ages for the B-, A-, and G-type Upper Sco members, as well as the evolved M supergiant Antares, and estimate a revised mean age for Upper Sco of 11 {+-} 1 {+-} 2 Myr (statistical, systematic). Using radial velocities and Hipparcos parallaxes we calculate a lower limit on the kinematic expansion age for Upper Sco of >10.5 Myr (99% confidence). However, the data are statistically consistent with no expansion. We reevaluate the inferred masses for the known

  8. SPITZER SPECTROSCOPY OF CIRCUMSTELLAR DISKS IN THE 5 Myr OLD UPPER SCORPIUS OB ASSOCIATION

    International Nuclear Information System (INIS)

    Dahm, S. E.; Carpenter, John M.

    2009-01-01

    We present mid-infrared spectra between 5.2 and 38 μm for 26 disk-bearing members of the ∼5 Myr old Upper Scorpius OB association obtained with the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope. We find clear evidence for changes in the spectral characteristics of dust emission between the early-type (B+A) and late-type (K+M) infrared excess stars. The early-type members exhibit featureless continuum excesses that become apparent redward of ∼8 μm. In contrast, 10 and 20 μm silicate features or polycyclic aromatic hydrocarbon emission are present in all but one of the late-type excess members of Upper Scorpius. The strength of silicate emission among late-type Upper Scorpius members is spectral-type dependent, with the most prominent features being associated with K5-M2-type stars. By fitting the spectral energy distributions (SED) of a representative sample of low-mass stars with accretion disk models, we find that the SEDs are consistent with models having inner disk radii ranging from ∼0.2 to 1.2 AU. Complementary high-resolution (R ∼ 33, 000) optical (λλ4800-9200) spectra for the Upper Scorpius excess stars were examined for signatures of gaseous accretion. Of the 35 infrared excess stars identified in Upper Scorpius, only seven (all late-type) exhibit definitive signatures of accretion. Mass-accretion rates for these stars were estimated to range from 10 -11 to 10 -8.9 M sun yr -1 . Compared to Class II sources in Taurus-Auriga, the disk population in Upper Scorpius exhibits reduced levels of near- and mid-infrared excess emission and an order of magnitude lower mass-accretion rates. These results suggest that the disk structure has changed significantly over the 2-4 Myr in age separating these two stellar populations. The ubiquity of depleted inner disks in the Upper Scorpius excess sample implies that such disks are a common evolutionary pathway that persists for some time.

  9. HD 144548: A young triply eclipsing system in the Upper Scorpius OB association

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    Alonso, R.; Deeg, H. J.; Hoyer, S.; Lodieu, N.; Palle, E.; Sanchis-Ojeda, R.

    2015-12-01

    The star HD 144548 (=HIP 78977; TYP 6212-1273-1) has been known as a detached eclipsing binary and a bona-fide member of the Upper Scorpius OB association. Continuous photometry from the K2 mission on Campaign Two has revealed the presence of additional eclipses due to the presence of a third star in the system. These are explained by a system composed of the two previously known members of the eclipsing system (Ba and Bb) with a period of 1.63 d, orbiting around an F7-F8V star with a period of 33.945 ± 0.002 d in an eccentric orbit (eA = 0.2652 ± 0.0003). The timing of the eclipses of Ba and Bb reveals the same 33.9 d periodicity, which we interpret as the combination of a light time effect combined with dynamical perturbations on the close system. Here we combine radial velocities and analytical approximations for the timing of the eclipses to derive masses and radii for the three components of the system. We obtain a mass of 1.44 ± 0.04 M⊙ and radius of 2.41 ± 0.03 R⊙ for the A component, and almost identical masses and radii of about 0.96 M⊙ and 1.33 R⊙ for each of the two components of the close binary. HD 144548 is the first triply eclipsing system for which radial velocities of all components could be measured. Partially based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei of the INAF, the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association, and the William Herschel Telescope (programme DDT58 - PI Lodieu) operated by the Isaac Newton Group on the island of La Palma at the Spanish Observatorio Roque de los Muchachos of the IAC. This paper includes data collected by the Kepler mission. Funding for the Kepler mission is provided by the NASA Science Mission directorate.Appendices are available in electronic form at http://www.aanda.org

  10. VizieR Online Data Catalog: VLM stars and BDs in Upper Sco using Gaia DR1 (Cook+, 2017)

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    Cook, N. J.; Scholz, A.; Jayawardhana, R.

    2018-04-01

    We used literature samples (Dawson et al. (2011MNRAS.418.1231D, Cat. J/MNRAS/418/1231), Lodieu et al. (2011MNRAS.418.2604L), Dawson et al. (2013MNRAS.429..903D, Cat. J/MNRAS/429/903), Lodieu (2013MNRAS.431.3222L, Cat. J/MNRAS/431/3222), Lodieu (2013MNRAS.435.2474L, Cat. J/MNRAS/435/2474) and Dawson et al. (2014MNRAS.442.1586D)) and UKIDSS photometric data (Lawrence et al. (2007MNRAS.379.1599L, Cat. II/314) along with new proper motion data (using data from Gaia DR1 i.e. Altmann et al. (2017A&A...600L...4A, Cat. I/339), Tian et al. (2017ApJS..232....4T)) to construct catalogues of objects in Upper Scorpius. (8 data files).

  11. OB ASSOCIATIONS AT THE UPPER END OF THE MILKY WAY LUMINOSITY FUNCTION

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    Rahman, Mubdi; Matzner, Christopher D.; Moon, Dae-Sik, E-mail: mubdi@pha.jhu.edu [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H8 (Canada)

    2013-04-01

    The Milky Way's most luminous, young, and massive (M {approx}> 10{sup 4} M{sub Sun }) star clusters and OB associations have largely evaded detection despite knowledge of their surrounding H II regions. We search for these clusters and associations within the 40 star-forming complexes from Rahman and Murray in the 13 most luminous Wilkinson Microwave Anisotropy Probe (WMAP) free-free emission sources of the Galaxy. Selecting for objects with the dust-reddened colors of OB stars, we identify new candidate associations using the Two Micron All Sky Survey point-source catalog. In 40 star-forming complexes searched, 22 contain cluster/association candidates with sizes and masses in the range of 3'-26' and 10{sup 2.3}-10{sup 5} M{sub Sun }. Of the 22 candidates, at least seven have estimated masses {approx}> 10{sup 4} M{sub Sun }, doubling the number of such massive clusters known in the Galaxy. Only one of the searched WMAP sources remains without a candidate. Applying our method to a statistically similar set of test locations, we estimate that 3.0 {+-} 0.6 of our 22 candidate associations are unrelated to the star-forming complexes. In addition, the apparent extinctions of our candidate associations correlate well with the predictions from a Galactic model. These facts, along with the clear detection of a known OB association and the previous spectral verification of one cluster found by this method, validate our method. In eight of the most luminous WMAP sources, the candidate associations can account for the observed free-free flux. With our new compilation, the Galactic census of young, massive stellar associations may now be about half complete.

  12. Variability of X-ray emission from OB stars

    International Nuclear Information System (INIS)

    Collura, A.; Sciortino, S.; Serio, S.; Vaiana, G. S.; Harnden, F.R. JR.; Osservatorio Astronomico, Palermo, Italy; Harvard-Smithsonian Center for Astrophysics, Cambridge, MA)

    1989-01-01

    The variability in soft X-ray emission of 12 OB stars is studied. Two different methods of analysis, one more suitable for detecting short-term variations, the other aimed at detecting long time-scale variations, are applied to all stars in the sample. The long-term variability analysis shows that Cyg-OB2 8A Zeta Pup and Delta Ori exhibit significant count rate variations between different data sections. Similar variations are marginally detected in 15 Mon; the count rate variations for the other eight stars are consistent with statistical fluctuations. The light curve of Cyg-OB2 8A suggests the existence of two different emission levels. The short-term variability analysis detects marginal variability in Tau Sco with an effective amplitude of about 30 percent and a time scale of about 50 s. The upper limits to the effective short-term variability amplitude for all other sample stars are in the 10-30 percent range. 30 refs

  13. Migration processes in SCO member states

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    Valentina Sergeevna Antonyuk

    2012-12-01

    Full Text Available The article concerns modern state and development of migration processes in SCO member states. As a main method of research statistical analysis was applied. The article shows that migration streams between SCO member states are rather intensive, and the problem of labor migration becomes more and more urgent. The countries of consuming and supplying of labour force are clearly differentiated in the region. For some countries, labor export is the key sector of economy. At the same time, interstate relations between SCO member states sometimes are rather disputed. The most urgent factors causing the development of migration processes in the region were determined. Among them, thefactor of growing outflows from China isespecially noted. It is noted that migration processes are discussed by SCO member states nowadays in terms of illegal migration and international criminality connected with it. It means that the question of labor migration is a real problem. It is indicated that the creation of a specific joint commission on migration policy affiliated with the Council of Foreign Ministers of SCO member states is the necessary condition of effective interaction in migration questions within the framework of Shanghai Cooperation Organization.

  14. Kharlamova, N. F. Climate Changes over the 20th and 21st Centuries in the Upper Basin of the Ob and Irtysh Rivers (Altai Region)

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    Fedorovna, K. N., II

    2015-12-01

    The Russian climate is more sensitive to global warming than the climate in many other parts of the world. According to the Second Climate Change National Assessment, since the mid-1970s, the average temperature has been rising with rate of 0.43 ° C / 10 years, which is more than two times higher than the rate of global warming. In the Altai region, the rate of temperature change is higher than the average for Russia with an annual surface air temperature increase equal to 1.8°C the 20th century. The maximum value of this increase the past 50 years (1963-2013) was found in the intermountain basins of Altai (+ 2.6°C) mainly due to the winter and spring warming with changes in the summer season being considerably smaller. This warming is accompanied with negative tendencies in annual precipitation over the entire Altai Krai. The mountain ranges of Altai are called the "water tower" of Northern Eurasia. The northward flow of numerous rivers streaming down from these ranges in the Basin of the Ob and the Irtysh Rivers is formed by melting of Altai glaciers and snowfields. Since the middle of the 19th century the largest glaciers in the Altai have retreated by 1.5-2 km and the thickness of their tails decreased by 50-70 m. The reduction of mountain glaciers poses a threat of depletion of water flow to major agricultural regions downstream affecting human activity and even the drinking water availability. Permafrost in the Altai Mountains is actively degraded (thawing), which represents a danger for infrastructure (first of all for roads and pipelines) and increases risk of catastrophic events (landslides, mudflows). Continued warming could contribute to a significant reduction of water resources, biodiversity and other negative processes in the region.The reported study was partially supported by the Russian Foundation for Baseline Research (project No. 15-45-04450).

  15. ORIGIN OF DUST AROUND V1309 SCO

    International Nuclear Information System (INIS)

    Zhu, Chunhua; Lü, Guoliang; Wang, Zhaojun

    2013-01-01

    The origin of dust grains in the interstellar medium is still an unanswered problem. Nicholls et al. found the presence of a significant amount of dust around V1309 Sco, which may originate from the merger of a contact binary. We investigate the origin of dust around V1309 Sco and suggest that these dust grains are produced in the binary-merger ejecta. By means of the AGBDUST code, we estimate that ∼5.2 × 10 –4 M ☉ dust grains are produced with a radii of ∼10 –5 cm. These dust grains are mainly composed of silicate and iron grains. Because the mass of the binary merger ejecta is very small, the contribution of dust produced by binary merger ejecta to the overall dust production in the interstellar medium is negligible. However, it is important to note that the discovery of a significant amount of dust around V1309 Sco offers a direct support for the idea that common-envelope ejecta provides an ideal environment for dust formation and growth. Therefore, we confirm that common envelope ejecta can be important source of cosmic dust

  16. Find an Ob-Gyn

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    ... Management Education & Events Advocacy For Patients About ACOG Find an Ob-Gyn Home About ACOG Find an Ob-Gyn Page Navigation ▼ About Us ACOG ... Districts ACOG Sections Careers at ACOG Contact Us Find an Ob-Gyn Search by State Search by ...

  17. SCoT: a Python toolbox for EEG source connectivity.

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    Billinger, Martin; Brunner, Clemens; Müller-Putz, Gernot R

    2014-01-01

    Analysis of brain connectivity has become an important research tool in neuroscience. Connectivity can be estimated between cortical sources reconstructed from the electroencephalogram (EEG). Such analysis often relies on trial averaging to obtain reliable results. However, some applications such as brain-computer interfaces (BCIs) require single-trial estimation methods. In this paper, we present SCoT-a source connectivity toolbox for Python. This toolbox implements routines for blind source decomposition and connectivity estimation with the MVARICA approach. Additionally, a novel extension called CSPVARICA is available for labeled data. SCoT estimates connectivity from various spectral measures relying on vector autoregressive (VAR) models. Optionally, these VAR models can be regularized to facilitate ill posed applications such as single-trial fitting. We demonstrate basic usage of SCoT on motor imagery (MI) data. Furthermore, we show simulation results of utilizing SCoT for feature extraction in a BCI application. These results indicate that CSPVARICA and correct regularization can significantly improve MI classification. While SCoT was mainly designed for application in BCIs, it contains useful tools for other areas of neuroscience. SCoT is a software package that (1) brings combined source decomposition and connectivtiy estimation to the open Python platform, and (2) offers tools for single-trial connectivity estimation. The source code is released under the MIT license and is available online at github.com/SCoT-dev/SCoT.

  18. SCoT: A Python Toolbox for EEG Source Connectivity

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    Martin eBillinger

    2014-03-01

    Full Text Available Analysis of brain connectivity has become an important research tool in neuroscience. Connectivity can be estimated between cortical sources reconstructed from the electroencephalogram (EEG. Such analysis often relies on trial averaging to obtain reliable results. However, some applications such as brain-computer interfaces (BCIs require single-trial estimation methods.In this paper, we present SCoT – a source connectivity toolbox for Python. This toolbox implements routines for blind source decomposition and connectivity estimation with theMVARICA approach. Additionally, a novel extension called CSPVARICA is available for labeled data. SCoT estimates connectivity from various spectral measures relying on vector autoregressive (VAR models. Optionally, these VAR models can be regularized to facilitate ill posed applications such as single-trial fitting.We demonstrate basic usage of SCoT on motor imagery (MI data. Furthermore, we show simulation results of utilizing SCoT for feature extraction in a BCI application. These results indicate that CSPVARICA and correct regularization can significantly improve MI classification. While SCoT was mainly designed for application in BCIs, it contains useful tools for other areas of neuroscience. SCoT is a software package that (1 brings combined source decomposition and connectivtiy estimation to the open Python platform, and (2 offers tools for single-trial connectivity estimation. The source code is released under the MIT license and is available online at github.com/SCoT-dev/SCoT.

  19. Glucose metabolism and recycling by hepatocytes of OB/OB and ob/ob mice

    International Nuclear Information System (INIS)

    Lahtela, J.T.; Wals, P.A.; Katz, J.

    1990-01-01

    Hepatocytes were prepared from livers of ob/ob (obese diabetic) mice and their lean (OB/OB) siblings that had been fasted for 24 h. The hepatocytes were incubated with [U-14C, 2-3H]-, [U-14C, 3-3H]-, and [U-14C, 6-3H]glucose at concentrations from 20 to 120 mM. 14C was recovered mainly in CO2, glycogen, and lactate. Tritium was recovered in water and glycogen. The yield in labeled products from [2-3H]glucose ranged from two to three times that from [U-14C]glucose. The yields from [3-3H]- and [6-3H]glucose were similar, and 1.3-1.7 times that from [U-14C]glucose. At 40 mM, total utilization of glucose by obese mice was about twice that for lean mice, but there was little difference at 120 mM. The rate of recycling between glucose and glucose 6-phosphate was calculated. An equation to calculate the rate of recycling of glucose from the 2-3H/U-14C ratio in glycogen is derived in the APPENDIX. Our results show that (1) the utilization of glucose by hepatocytes from obese diabetic mice exceeds that of their lean controls, (2) the rate of glucose phosphorylation in both groups greatly exceeds glucose uptake and the rate of glycogen synthesis, (3) glucose phosphorylation represents a difference between a high glucokinase rate and hydrolysis of glucose 6-phosphate, and (4) recycling of glucose carbon between glucose 6-phosphate and pyruvate occurs within mouse hepatocytes

  20. Contemporary Expert Debates on the SCO-Related Issues

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    Igor Evgen'evich Denisov

    2016-01-01

    Full Text Available Since its establishment the SCO has always attracted a lot of expert attention. The SCO Forum was founded in 2006 to bring together for annual debates experts from all member-states. Within this format in-depth discussions took place in April 2016 in Dushanbe, which hosted this year conference of the SCO Forum. Participating experts and officials reviewed problems of security, economic cooperation (including transport and water-energy issues and SCO enlargement, the latter being one of the most debatable. Experts presented some new thesis on all these problems, in particular on the enlargement issue. These new thesis are summed up in this article. Besides, the SCO Forum this year had many statements on the organization approaching a sort of new phase in its development. This line of discussions may lead in the future to even more active debates on SCO's role in the world. This article puts emphasis on the new elements of these debates and reviews major experts' attitudes within this line of discussion on the SCO being in front of a new stage of development.

  1. INDIA, SCO AND BRICS IN MODERN GEOPOLITICS

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    Tatiana L. Shaumyan

    2013-01-01

    Full Text Available The first decade of the third millennium has witnessed the formation of newly forged associations, a substantial growth of regional organizations, an upsurge in their activity and also their increasing adaptability to globalization processes. A keen interest to participate in such regional alliances has been displayed by nations representing diverse structural systems, differing sizes of economy and various natural, economic, human and military potentials. Among these are both developed and developing states, great powers, neighboring states as well as those located on separate continents (India-Brazil-South Africa, Brazil-Russia-India-China-plus South Africa. The same state may decide to join one or several regional and sub-regional organizations as well as non-institutionalized groups. India has participated in such organizations and associations as SCO, SAARC, RIC, BIMSTEC and BRICS. Indian participation in the activities of regional and global organizations does not damage its independent foreign policy; its growing assertiveness as a world economic power occupies a special place in global politics. India determines its foreign policy and its relations with other world powers, with developed and developing countries alike, based on its national interests

  2. Identified corrosion and erosion mechanisms in SCO2 Brayton Cycles.

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    Fleming, Darryn D.; Kruizenga, Alan Michael

    2014-06-01

    Supercritical Carbon Dioxide (S-CO2) is an efficient and flexible working fluid for power production. Research to interface S-CO2 systems with nuclear, thermal solar, and fossil energy sources is currently underway. To proceed, we must address concerns regarding compatibility of materials, at high temperature, and compatibility between significantly different heat transfer fluids. Dry, pure S-CO2 is thought to be relatively inert [1], while the addition of ppm levels of water and oxygen result in formation of a protective chromia layer and iron oxide [2]. Thin oxides are favorable as diffusion barriers, and for their minimal impact on heat transfer. While S-CO2 is typically understood to be the secondary fluid, many varieties of primary fluids exist for nuclear applications. Molten salts, for use in the Molten Salt Reactor concept, are given as an example to contrast the materials requirements of primary and secondary fluids. Thin chromia layers are soluble in molten salt systems (nitrate, chloride, and fluoride based salts) [3-8], making materials selection for heat exchangers a precarious balancing act between high temperature oxidation (S-CO2) and metal dissolution (salt side of heat exchanger). Because concerns have been raised regarding component lifetimes, S-CO2 work has begun to characterize starting materials and to establish a baseline by analysis of 1) as-received stainless steel piping, and 2) piping exposed to S-CO2 under typical operating conditions with Sandia National Laboratories Brayton systems. A second issue discovered by SNL involves substantial erosion in the turbine blade and inlet nozzle. It is believed that this is caused by small particulates that originate from different materials around the loop that are entrained by the S-CO2 to the nozzle, where they impact the inlet nozzle vanes, causing erosion. We believe that, in some way, this is linked to the purity of the S-CO2, the corrosion contaminants, and the metal particulates that

  3. Direct Imaging and Spectroscopy of a Young Extrasolar Kuiper Belt in the Nearest OB Association

    OpenAIRE

    Currie, Thayne; Lisse, Carey M.; Kuchner, Marc J.; Madhusudhan, Nikku; Kenyon, Scott J.; Thalmann, Christian; Carson, Joseph; Debes, John H.

    2015-01-01

    We describe the discovery of a bright, young Kuiper belt-like debris disk around HD 115600, a $\\sim$ 1.4--1.5 M$_\\mathrm{\\odot}$, $\\sim$ 15 Myr old member of the Sco-Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the \\textit{Gemini Planet Imager} shows the ring has a (luminosity scaled) semi major axis of ($\\sim$ 22 AU) $\\sim$ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral scattering dust, is eccentric (e $\\sim$ 0.1--0.2), and could b...

  4. Peripheral nervous system insulin resistance in ob/ob mice

    Science.gov (United States)

    2013-01-01

    Background A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated with several neurological disorders and recent evidence has indicated that dorsal root ganglion (DRG) neurons in primary culture display altered insulin signaling, yet in vivo results are lacking. Here, experiments were performed to test the hypothesis that the PNS of insulin-resistant mice displays altered insulin signal transduction in vivo. For these studies, nondiabetic control and type 2 diabetic ob/ob mice were challenged with an intrathecal injection of insulin or insulin-like growth factor 1 (IGF-1) and downstream signaling was evaluated in the DRG and sciatic nerve using Western blot analysis. Results The results indicate that insulin signaling abnormalities documented in other “insulin sensitive” tissues (i.e. muscle, fat, liver) of ob/ob mice are also present in the PNS. A robust increase in Akt activation was observed with insulin and IGF-1 stimulation in nondiabetic mice in both the sciatic nerve and DRG; however this response was blunted in both tissues from ob/ob mice. The results also suggest that upregulated JNK activation and reduced insulin receptor expression could be contributory mechanisms of PNS insulin resistance within sensory neurons. Conclusions These findings contribute to the growing body of evidence that alterations in insulin signaling occur in the PNS and may be a key factor in the pathogenesis of diabetic neuropathy. PMID:24252636

  5. sCO2 Power Cycles Summit Summary November 2017.

    Energy Technology Data Exchange (ETDEWEB)

    Mendez Cruz, Carmen Margarita; Rochau, Gary E.; Lance, Blake

    2018-04-01

    Over the past ten years, the Department of Energy (DOE) has helped to develop components and technologies for the Supercritical Carbon Dioxide (sCO2) power cycle capable of efficient operation at high temperatures and high efficiency. The DOE Offices of Fossil Energy, Nuclear Energy, and Energy Efficiency and Renewable Energy collaborated in the planning and execution of the sCO2 Power Cycle Summit conducted in Albuquerque, NM in November 2017. The summit brought together participants from government, national laboratories, research, and industry to engage in discussions regarding the future of sCO 2 Power Cycles Technology. This report summarizes the work involved in summit planning and execution, before, during, and after the event, including the coordination between three DOE offices and technical content presented at the event.

  6. Low energy gamma rays emitted by Sco X-1

    International Nuclear Information System (INIS)

    Bui-Van, A.; Martin, I.M.

    1975-01-01

    Sco X-1 was observed on a balloon flight launched from Sao Jose dos Campos, S.P., Brazil, on December 20, 1974. A 3 sigma excess of the raw count rate, covering the energy range 0.2 to 5.0 MeV, was found during the transit of the source. A power-law spectrum provided an adequate fit to the data. Although it was difficult to separate the contribution of the universal diffuse component, the existence of hard-component in the spectrum of Sco X-1 could indicate the presence of matter hotter than previously deduced from soft X-ray observations [pt

  7. H II regions ionized by sigma and tau Sco

    Energy Technology Data Exchange (ETDEWEB)

    Gaylard, M J [Council for Scientific and Industrial Research, Pretoria (South Africa). National Inst. for Telecommunications Research

    1984-11-15

    The H142..cap alpha.. line has been detected in Sharpless 9, which is ionized by sigmaSco, and in RCW 129, ionized by tau Sco. The electron temperatures in the two H II regions are 5700 +- 340 K and 4200 +- 600 K respectively. The thermal radio emission from S9 is asymmetric with respect to the stellar position, and the emission peak coincides with the position of the optical red emission features to the north and west of the star. There is no evidence for collisional excitation. S9 is a density-bounded H II region in the champagne phase, the bright rims and radio peak marking the ionization front.

  8. Response of the middle atmosphere to Sco X-1

    Science.gov (United States)

    Goldberg, R. A.; Barcus, J. R.; Mitchell, J. D.

    1985-10-01

    On the night of Mar. 9, 1983 (UT) at Punta Lobos Launch Site, Peru (12.5 deg S, 76.8 deg W, magnetic dip -0.7 deg), a sequence of sounding rockets was flown to study the electrical structure of the equatorial middle atmosphere and to evaluate perturbations on this environment induced by the X-ray star Sco X-1. The rocket series was anchored by two Nike Orion payloads (31.032 and 31.033) which were launched at 0327 and 0857 UT, near Sco X-1 star-rise and after it had attained an elevation angle of 70 deg E. An enhanced flux of X-rays was observed on the second Nike Orion flight (31.033). This increase is directly attributed to Sco X-1, both from the spectral properties of the measured X-ray distribution and by spatial information acquired from a spinning X-ray detector during the upleg portion of the 31.033 flight. Simultaneously, a growth in ion conductivity and density was seen to occur in the lower mesosphere between 60 and 80 km on the second flight, specifically in the region of maximum energy deposition by the Sco X-1 X-rays. The results imply the presence of a significant number of ionized heavy constituents within the lower mesosphere, with masses possibly in the submacroscopoic range.

  9. Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

    International Nuclear Information System (INIS)

    Won, Young-Suk; Song, Ji-Won; Lim, Jong-Hwan; Lee, Mee-Young; Moon, Og-Sung; Kim, Hyoung-Chin; Son, Hwa-Young; Kwon, Hyo-Jung

    2016-01-01

    Obesity increases the risk of chronic liver diseases, including viral hepatitis, alcohol-induced liver disease, and non-alcoholic steatohepatitis. In this study, we investigated the effects of obesity in acute hepatic failure using a murine model of thioacetamide (TA)-induced liver injury. Genetically obese ob/ob mice, together with non-obese ob/+ littermates, were subjected to a single intraperitoneal injection of TA, and examined for signs of hepatic injury. ob/ob mice showed a significantly higher survival rate, lower levels of serum alanine aminotransferase and aspartate aminotransferase, and less hepatic necrosis and apoptosis, compared with ob/+ mice. In addition, ob/ob mice exhibited significantly lower levels of malondialdehyde and significantly higher levels of glutathione and antioxidant enzyme activities compared with their ob/+ counterparts. Bioactivation analyses revealed reduced plasma clearance of TA and covalent binding of [ 14 C]TA to liver macromolecules in ob/ob mice. Together, these data demonstrate that genetically obese mice are resistant to TA-induced acute liver injury through diminished bioactivation of TA and antioxidant effects. - Highlights: • ob/ob mice are resistant to lethal doses of thioacetamide, compared to ob/+ mice. • ob/ob mice show reduced oxidative stress and enhanced antioxidant enzyme activity. • ob/ob mice exhibit diminished bioactivation of thioacetamide.

  10. Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Won, Young-Suk [Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk (Korea, Republic of); Song, Ji-Won [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of); Lim, Jong-Hwan [Huons Research Center, Gyonggido (Korea, Republic of); Lee, Mee-Young [Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, Daejeon (Korea, Republic of); Moon, Og-Sung; Kim, Hyoung-Chin [Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk (Korea, Republic of); Son, Hwa-Young [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of); Kwon, Hyo-Jung, E-mail: hyojung@cnu.ac.kr [Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon (Korea, Republic of)

    2016-01-15

    Obesity increases the risk of chronic liver diseases, including viral hepatitis, alcohol-induced liver disease, and non-alcoholic steatohepatitis. In this study, we investigated the effects of obesity in acute hepatic failure using a murine model of thioacetamide (TA)-induced liver injury. Genetically obese ob/ob mice, together with non-obese ob/+ littermates, were subjected to a single intraperitoneal injection of TA, and examined for signs of hepatic injury. ob/ob mice showed a significantly higher survival rate, lower levels of serum alanine aminotransferase and aspartate aminotransferase, and less hepatic necrosis and apoptosis, compared with ob/+ mice. In addition, ob/ob mice exhibited significantly lower levels of malondialdehyde and significantly higher levels of glutathione and antioxidant enzyme activities compared with their ob/+ counterparts. Bioactivation analyses revealed reduced plasma clearance of TA and covalent binding of [{sup 14}C]TA to liver macromolecules in ob/ob mice. Together, these data demonstrate that genetically obese mice are resistant to TA-induced acute liver injury through diminished bioactivation of TA and antioxidant effects. - Highlights: • ob/ob mice are resistant to lethal doses of thioacetamide, compared to ob/+ mice. • ob/ob mice show reduced oxidative stress and enhanced antioxidant enzyme activity. • ob/ob mice exhibit diminished bioactivation of thioacetamide.

  11. SCoPE: an efficient method of Cosmological Parameter Estimation

    International Nuclear Information System (INIS)

    Das, Santanu; Souradeep, Tarun

    2014-01-01

    Markov Chain Monte Carlo (MCMC) sampler is widely used for cosmological parameter estimation from CMB and other data. However, due to the intrinsic serial nature of the MCMC sampler, convergence is often very slow. Here we present a fast and independently written Monte Carlo method for cosmological parameter estimation named as Slick Cosmological Parameter Estimator (SCoPE), that employs delayed rejection to increase the acceptance rate of a chain, and pre-fetching that helps an individual chain to run on parallel CPUs. An inter-chain covariance update is also incorporated to prevent clustering of the chains allowing faster and better mixing of the chains. We use an adaptive method for covariance calculation to calculate and update the covariance automatically as the chains progress. Our analysis shows that the acceptance probability of each step in SCoPE is more than 95% and the convergence of the chains are faster. Using SCoPE, we carry out some cosmological parameter estimations with different cosmological models using WMAP-9 and Planck results. One of the current research interests in cosmology is quantifying the nature of dark energy. We analyze the cosmological parameters from two illustrative commonly used parameterisations of dark energy models. We also asses primordial helium fraction in the universe can be constrained by the present CMB data from WMAP-9 and Planck. The results from our MCMC analysis on the one hand helps us to understand the workability of the SCoPE better, on the other hand it provides a completely independent estimation of cosmological parameters from WMAP-9 and Planck data

  12. Response of the middle atmosphere to Sco X-1

    International Nuclear Information System (INIS)

    Goldberg, R.A.; Barcus, J.R.; Mitchell, J.D.

    1985-01-01

    On the night of 9 March 1983 (UT) at Punta Lobos Launch Site, Peru, a sequence of sounding rockets was flown to study the electrical structure of the equatorial middle atmosphere and to evaluate perturbations on this environment induced by the X-ray star Sco X-1. The rocket series was anchored by two Nike Orion payloads which were launched at 0327 and 0857 UT, near Sco X-1 star-rise and after it had attained an elevation angle of 70 deg E. Each of these payloads carried instrumentation during parachute descent to measure X-ray and electron fluxes, ion density, conductivity and mobility, and in situ electric fields. In addition, several smaller payloads capable of measuring the atmospheric electrical parameters were launched at times interspersed among the large rockets. An enhanced flux of X-rays was observed on the second Nike Orion flight. This increase is directly attributed to Sco X-1, both from the spectral properties of the measured X-ray distribution and by spatial information acquired from a spinning X-ray detector during the upleg portion of the 31.033 flight. Simultaneously, a growth in ion conductivity and density was seen to occur in the lower mesosphere between 60 and 80 km on the second flight. The results are discussed. (author)

  13. Recent Seismic Experiments of OBS in the South China Sea

    Science.gov (United States)

    Ruan, A.; Li, J.; Wu, Z.

    2012-12-01

    Since 2006 some research institutions of China have carried out some important seismic experiments by using ocean bottom seismometer(OBS) in the South China Sea (SCS) and obtained many concrete progresses in modeling the crustal structure of SCS and also in understanding of its formation and evolution as well. In 2006 three wide-angle profiles were completed in the northern margin, named OBS2006-1 across the northwestern sub-basin, OBS2006-2 parallel to the sea basin boundary and OBS2006-3 across the Dongsha Rise and Chaoshan Depression respectively. In 2010 two wide- angle profiles were completed, named OBS2010-1 and OBS 2010-2 both perpendicular to the northern off-shore faulting system. During 2009-2011 four wide-angle profiles were completed in the southern margin, named OBS973-1 from southern margin to the southwestern sub-basin, OBS973-2 from Liyue Bank to the southwestern sub-basin and OBS973-3 from Xisha to the southwestern sub-basin, OBS2011-2 from Xisha to Hainan Island respectively. In 2011 two 3D seismic array of OBS were completed in the Zhongnan-Changlong sea mount chain and Huangyan-Zhenbei sea mount chain respectively. Here we present some primary but important results as follows. (1) The velocity model of OBS2006-1 indicates that the crust under the continental slope decreases from 21km to 11km, and to 7.7km in the northwestern sub-basin with Moho depth ascends from 21km to 11km. The tectonic geometry and velocity structure of the northwestern sub-basin and its margins on both sides shows symmetrical and conjugate and indicates pure shear mode of continental margin rifting mechanism. (2) The velocity model of OBS2006-3 reveals remarkable thickness with maximum 8 km of the Mesozoic sediment in Chaoshan Depression in which velocity increases downward from 4.4 km/s at top to 5.3 km/s at the bottom. The buried depth of Moho decreases from 24-25 km under Dongsha Rise to 17 km in the lower slope and an obviously velocity abnormal is detected in the upper

  14. Investigating the Current State of V1535 Sco

    Science.gov (United States)

    Linford, Justin

    2017-09-01

    We request 25 ks of time on the ACIS instrument to image the nova system V1535 Sco in quiescence. The observations will reveal several details about the physics of the system. The presence of X-rays and variations in the light curve will prove the resumption of accretion onto the white dwarf. Absorption, especially in the soft X-rays, will probe the presence of a strong stellar wind from the companion star. The X-ray spectrum will place limits on the white dwarf mass.

  15. Complete Genome Sequence of the Novel Bacteriophage pSco-10 Infecting Staphylococcus cohnii.

    Science.gov (United States)

    Jun, Jin Woo; Giri, Sib Sankar; Kim, Hyoun Joong; Chi, Cheng; Yun, Saekil; Kim, Sang Guen; Kim, Sang Wha; Kang, Jeong Woo; Park, Se Chang

    2017-11-22

    Herein, we report the complete genome sequence of the Staphylococcus Myoviridae phage pSco-10 infecting Staphylococcus cohnii The phage pSco-10 was isolated from duck feces collected from four farms in South Korea. The current report provides valuable information for genomic study of phages. Copyright © 2017 Jun et al.

  16. Complete Genome Sequence of the Novel Bacteriophage pSco-10 Infecting Staphylococcus cohnii

    OpenAIRE

    Jun, Jin Woo; Giri, Sib Sankar; Kim, Hyoun Joong; Chi, Cheng; Yun, Saekil; Kim, Sang Guen; Kim, Sang Wha; Kang, Jeong Woo; Park, Se Chang

    2017-01-01

    ABSTRACT Herein, we report the complete genome sequence of the Staphylococcus Myoviridae phage pSco-10 infecting Staphylococcus cohnii. The phage pSco-10 was isolated from duck feces collected from four farms in South Korea. The current report provides valuable information for genomic study of phages.

  17. Observations and simulations of recurrent novae: U Sco and V394 CrA

    Science.gov (United States)

    Starrfield, S.; Sonneborn, G.; Sparks, Warren M.; Shaviv, G.; Williams, R. E.; Heathcote, S.; Ferland, Gary; Gehrz, Robert D.; Ney, Edward P.; Kenyon, Scott

    1988-01-01

    Observations and analysis of the Aug. 1987 outburst of the recurrent nova V394 CrA are presented. This nova is extremely fast and its outburst characteristics closely resemble those of the recurrent nova U Sco. Hydrodynamic simulations of the outbursts of recurrent novae were performed. Results as applied to the outbursts of V394 CrA and U Sco are summarized.

  18. SCO shipments from Rocky Flats - Experience and current practice [Surface Contaminated Object

    International Nuclear Information System (INIS)

    Bracken, Gary; Morris, Robert L.

    2001-01-01

    Decommissioning activities at Rocky Flats Environmental Technology Site (RFETS) are expected to generate approximately 251,000 cubic meters of low-level radioactive waste. Almost half of this will be characterized and shipped as the Department of Transportation ''Surface Contaminated Object'' (SCO) shipping class. In the 2 years since an SCO characterization method was implemented, almost 11,000 of the 18,000 cubic meters of low-level waste were SCO. RFETS experience to-date using an SCO waste characterization method has shown significant time and cost savings, reduced errors, and enhanced employee safety. SCO waste is characterized prior to packaging, near the point of generation, by any of the site's 300 Radiological Control Technicians using inexpensive radiological control survey instruments. This reduces on-site waste container moves and eliminates radiometric analysis at centrally located drum or crate counters. Containers too large for crate counters can also be characterized. Current instrumentation is not adequate to take full advantage of the SCO regulations. Future improvements in the SCO characterization and shipping process are focused on use of larger and/or reusable containers, extended-range instruments, and additional statistical methods, so that the full extent of the SCO regulations can be used

  19. Zinc metabolism in genetically obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Kennedy, M.L.; Failla, M.L.

    1987-01-01

    Recent reports indicate that the concentrations and total amounts of several essential trace metals in various tissues of genetically obese rodents differ markedly from those in lean controls. In the present studies the absorption, retention and tissue distribution of zinc and constitutive levels of zinc-metallothionein (Zn-MT) in selected tissues were compared in obese (ob/ob) and lean (+/?) C57BL/6J mice. When 5-, 10- and 22-wk-old mice were administered 1.2 mumol 65 Zn by stomach tube the apparent absorption of 65 Zn by obese mice was 1.5, 2.2 and 3.9 times higher, respectively, than that in age-matched lean mice. Retention of orally administered 65 Zn after 96 h was also substantially higher in obese mice than in lean mice. To assess the possible influences of hyperphagia and intestinal hypertrophy on the enhanced apparent absorption of 65 Zn by obese mice food intake by an additional group of obese mice was restricted to that of age-matched lean controls. When actual absorption of zinc was determined according to the method of Heth and Hoekstra, groups of ad libitum--fed obese, pair-fed obese and lean mice absorbed 38, 32 and 18% of administered 65 Zn, respectively. In contrast, the rate of 65 Zn excretion 2-6 d after oral or subcutaneous administration of the metal was similar for obese and lean mice. Unrestricted and pair-fed obese mice had significantly lower percentages of carcass 65 Zn present in skin, muscle plus bone, spleen and testes and higher percentages present in liver, small intestine and adipose tissue than lean mice

  20. Role of GntR Family Regulatory Gene SCO1678 in Gluconate Metabolism in Streptomyces coelicolor M145

    Directory of Open Access Journals (Sweden)

    Olga Tsypik

    2017-01-01

    Full Text Available Here we report functional characterization of the Streptomyces coelicolor M145 gene SCO1678, which encodes a GntR-like regulator of the FadR subfamily. Bioinformatic analysis suggested that SCO1678 is part of putative operon (gnt involved in gluconate metabolism. Combining the results of SCO1678 knockout, transcriptional analysis of gnt operon, and Sco1678 protein-DNA electromobility shift assays, we established that Sco1678 protein controls the gluconate operon. It does so via repression of its transcription from a single promoter located between genes SCO1678 and SCO1679. The knockout also influenced, in a medium-dependent manner, the production of secondary metabolites by S. coelicolor. In comparison to the wild type, on gluconate-containing minimal medium, the SCO1678 mutant produced much less actinorhodin and accumulated a yellow-colored pigment, likely to be the cryptic polyketide coelimycin. Possible links between gluconate metabolism and antibiotic production are discussed.

  1. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

    Science.gov (United States)

    Sartori, Michelle; Conti, Filipe F.; Dias, Danielle da Silva; dos Santos, Fernando; Machi, Jacqueline F.; Palomino, Zaira; Casarini, Dulce E.; Rodrigues, Bruno; De Angelis, Kátia; Irigoyen, Maria-Claudia

    2017-01-01

    Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF) and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress. Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals. PMID:28878683

  2. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Michelle Sartori

    2017-08-01

    Full Text Available Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice.Methods: Metabolic parameters, cardiac function, arterial pressure (AP, autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group and ob/ob mice (OB group.Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Ejection fraction (EF and AP were similar between groups; however, the OB group presented diastolic dysfunction, as well as an impairment on myocardial performance index. Moreover, the OB group exhibited important autonomic dysfunction and baroreflex sensitivity impairment, when compared to WT group. OB group showed increased Angiotensin II levels in heart and renal tissues; decreased adiponectin and increased inflammatory markers in adipose tissue and spleen. Additionally, OB mice presented a higher damage to proteins and lipoperoxidation and lower activity of antioxidant enzymes in kidney and heart. Correlations were found between autonomic dysfunction with angiotensin II and inflammatory mediators, as well as between inflammation and oxidative stress.Conclusions: Our results showed that female adult ob/ob mice presented discrete diastolic dysfunction accompanied by autonomic disorder, which is associated with inflammation and oxidative stress in these animals.

  3. 2MASS Identifications for Galactic OB Stars

    OpenAIRE

    Reed, B. Cameron

    2007-01-01

    Cross-identifications for 14,574 intrinsically luminous galactic stars (mostly OB stars) to objects in the 2MASS survey have been determined using a search box of +/-0.0015 degrees (+/- 5.4 arcsec) in both RA and Dec. Instructions on obtaining the relevant files can be obtained at othello.alma.edu/~reed/OB-2MASS.doc.

  4. The Peculiar Multiwavelength Evolution Of V1535 Sco

    Science.gov (United States)

    Linford, J. D.; Chomiuk, L.; Nelson, T.; Finzell, T.; Walter, F. M.; Sokoloski, J. L.; Mukai, K.; Mioduszewski, A. J.; van der Horst, A. J.; Weston, J. H. S.; Rupen, M. P.

    2017-06-01

    We present multiwavelength observations of the unusual nova V1535 Sco throughout its outburst in 2015. Early radio observations were consistent with synchrotron emission, and early X-ray observations revealed the presence of high-energy (>1 keV) photons. These indicated that strong shocks were present during the first ∼2 weeks of the nova's evolution. The radio spectral energy distribution was consistent with thermal emission from week 2 to week 6. Starting in week 7, the radio emission again showed evidence of synchrotron emission, and there was an increase in X-ray emission, indicating a second shock event. The optical spectra show evidence of at least two separate outflows, with the faster outflow possibly having a bipolar morphology. The optical and near-infrared light curves and the X-ray {N}{{H}} measurements indicated that the companion star is likely a K giant.

  5. Preliminary S-CO_2 Compressor Design for Micro Modular Reactor

    International Nuclear Information System (INIS)

    Lee, Jekyoung; Cho, Seong Kuk; Kim, Seong Gu; Lee, Jeong Ik

    2016-01-01

    Due to economic benefit of S-CO_2 Brayton cycle which is came from high efficiency and compactness, active research is currently conducted by various research groups and various approaches are suggested to take benefits of S-CO_2 Brayton cycle. KAIST research team also has been working on advanced concept for application of S-CO_2 Brayton cycle to nuclear system and Micro Modular Reactor (MMR) concept was suggested. The preliminary compressor design of S-CO_2 compressor for MMR system was carried out to observe feasibility of compressor design. Preliminary S-CO_2 compressor design for MMR system was successfully conducted and some issues are discovered from the design study. From the previous work done by Cho, conceptual design for MMR system was provided. Thus, further preliminary design should be carried out to obtain feasible S-CO_2 compressor design for MMR system. KAIST_TMD which is turbomachinery in-house code for real gases including S-CO_2 is continuously updated and currently it has 3D geometry construction and design optimization capability

  6. A DYNAMICAL STUDY OF SUSPECTED RUNAWAY STARS AS TRACES OF PAST SUPERNOVA EXPLOSIONS IN THE REGION OF THE SCORPIUS-CENTAURUS OB ASSOCIATION

    International Nuclear Information System (INIS)

    Jilinski, E.; Ortega, V. G.; Drake, N. A.; De la Reza, R.

    2010-01-01

    We address the question of identifying possible past supernovae events taking place in the region of the Scorpius-Centaurus (Sco-Cen) OB association based on stars proposed by Hoogerwerf et al. With this purpose, we obtained a time series of high-resolution spectra of six stars (HIP 42038, HIP 46950, HIP 48943, HIP 69491, HIP 76013, and HIP 82868) which, according to Hoogerwerf et al., may have been runaway stars with origins in the region of the Sco-Cen association. This also includes the nearby young open clusters IC 2391 and IC 2602. If confirmed, such supernovae events could, in principle, have played a role in triggering the formation of some small stellar groups thought to be associated with the Sco-Cen association. Our analysis shows that, except for HIP 48943, the remaining stars are spectroscopic binary systems. For HIP 46950 and HIP 69491, this was already noted by other authors. Our high-resolution spectra allowed us to obtain the radial velocities for all the stars which, combined with their proper motions and parallaxes from Hipparcos, provide a means to investigate, by retracing their orbits, if the Sco-Cen region was, in fact, the origin of these stars. We find that none of these systems originated in the Sco-Cen region. Exploring the possibility that the birthplace of the studied stars occurred in the clusters IC 2391 and IC 2602, we noticed that at the epoch of 2-3 Myr ago these clusters were at a distance comparable with their tidal radii.

  7. Structural anatomy of telomere OB proteins.

    Science.gov (United States)

    Horvath, Martin P

    2011-10-01

    Telomere DNA-binding proteins protect the ends of chromosomes in eukaryotes. A subset of these proteins are constructed with one or more OB folds and bind with G+T-rich single-stranded DNA found at the extreme termini. The resulting DNA-OB protein complex interacts with other telomere components to coordinate critical telomere functions of DNA protection and DNA synthesis. While the first crystal and NMR structures readily explained protection of telomere ends, the picture of how single-stranded DNA becomes available to serve as primer and template for synthesis of new telomere DNA is only recently coming into focus. New structures of telomere OB fold proteins alongside insights from genetic and biochemical experiments have made significant contributions towards understanding how protein-binding OB proteins collaborate with DNA-binding OB proteins to recruit telomerase and DNA polymerase for telomere homeostasis. This review surveys telomere OB protein structures alongside highly comparable structures derived from replication protein A (RPA) components, with the goal of providing a molecular context for understanding telomere OB protein evolution and mechanism of action in protection and synthesis of telomere DNA.

  8. Hydrogen sulfide improves diabetic wound healing in ob/ob mice via attenuating inflammation.

    Science.gov (United States)

    Zhao, Huichen; Lu, Shengxia; Chai, Jiachao; Zhang, Yuchao; Ma, Xiaoli; Chen, Jicui; Guan, Qingbo; Wan, Meiyan; Liu, Yuantao

    2017-09-01

    The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H 2 S) has been reported to have multiple biological activities. We aim to investigate the role of H 2 S in impaired wound healing in ob/ob mice and explore the possible mechanisms involved. Full-thickness skin dorsal wounds were created on ob/ob mice and C57BL/6 mice. Cystathionine-γ-lyase (CSE) expression and H 2 S production were determined in granulation tissues of the wounds. Effects of NaHS on wound healing were evaluated. Inflammation and angiogenesis in granulation tissues of the wounds were examined. CSE expression, and H 2 S content were significantly reduced in granulation tissues of wounds in ob/ob mice compared with control mice. NaHS treatment significantly improved wound healing in ob/ob mice, which was associated with reduced neutrophil and macrophage infiltration, decreased production of tumor necrosis factor (TNF)-α, interleukin (IL)-6. NaHS treatment decreased metalloproteinase (MMP)-9, whereas increased collagen deposition and vascular-like structures in granulation tissues of wounds in ob/ob mice. CSE down-regulation may play a role in the pathogenesis of diabetic impaired wound healing. Exogenous H 2 S could be a potential agent to improve diabetic impaired wound healing by attenuating inflammation and increasing angiogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Impaired Muscle Regeneration in Ob/ob and Db/db Mice

    Directory of Open Access Journals (Sweden)

    Mai-Huong Nguyen

    2011-01-01

    Full Text Available In obesity and type 2 diabetes, efficient skeletal muscle repair following injury may be required, not only for restoring muscle structure and function, but also for maintaining exercise capacity and insulin sensitivity. The hypothesis of this study was that muscle regeneration would be impaired in ob/ob and db/db mice, which are common mouse models of obesity and type 2 diabetes. Muscle injury was produced by cardiotoxin injection, and regeneration was assessed by morphological and immunostaining techniques. Muscle regeneration was delayed in ob/ob and db/db mice, but not in a less severe model of insulin resistance – feeding a high-fat diet to wild-type mice. Angiogenesis, cell proliferation, and myoblast accumulation were also impaired in ob/ob and db/db mice, but not the high-fat diet mice. The impairments in muscle regeneration were associated with impaired macrophage accumulation; macrophages have been shown previously to be required for efficient muscle regeneration. Impaired regeneration in ob/ob and db/db mice could be due partly to the lack of leptin signaling, since leptin is expressed both in damaged muscle and in cultured muscle cells. In summary, impaired muscle regeneration in ob/ob and db/db mice was associated with reduced macrophage accumulation, angiogenesis, and myoblast activity, and could have implications for insulin sensitivity in the skeletal muscle of obese and type 2 diabetic patients.

  10. HSL Attenuates the Follicular Oxidative Stress and Enhances the Hair Growth in ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Takeo Minematsu, PhD

    2013-10-01

    Full Text Available Summary: We demonstrated enhanced hair regeneration following topical administration of N-(3-oxododecanoyl-L-homoserine lactone (HSL in ob/ob mice. The ob/ob mice showed delayed hair regeneration (more than 6 wk after depilation, which rapidly induced transition to anagen in the hair cycle in wild-type mice. Vehicle and HSL solutions were applied to the depilated dorsal skin of ob/ob mice. The depilated skin of the HSL-treated mice was fully covered with hair, whereas no macroscopic alteration was observed in vehicle-treated group by the fourth week after depilation. Oxidative stress was drastically decreased and the expression of the antioxidative enzymes PON1 and PON3 was increased in the HSL-treated skin with highly proliferative anagen follicles. These results suggest that HSL is a candidate therapeutic agent for alopecia in metabolic syndrome.

  11. Serotonin transporter (SERT and translocator protein (TSPO expression in the obese ob/ob mouse

    Directory of Open Access Journals (Sweden)

    Santini Ferruccio

    2011-02-01

    Full Text Available Abstract Background An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and cell metabolism, the serotonin transporter SERT and the cholesterol import-benzodiazepine site TSPO (translocator protein, in a rodent leptin-lacking mutant, the obese ob/ob mouse. Binding studies were thus carried out in brain or peripheral tissues, blood platelets (SERT and kidneys (TSPO, of ob/ob and WT mice supplied with a standard diet, using the selective radiochemical ligands [3H]-paroxetine and [3H]-PK11195. Results We observed comparable SERT number or affinity in brain and platelets of ob/ob and WT mice, whilst a significantly higher [3H]-PK11195 density was reported in the brain of ob/ob animals. TSPO binding parameters were similar in the kidneys of all tested mice. By [3H]-PK11195 autoradiography of coronal hypothalamic-hippocampal sections, an increased TSPO signal was detected in the dentate gyrus (hippocampus and choroids plexus of ob/ob mice, without appreciable changes in the cortex or hypothalamic-thalamic regions. Conclusions These findings show that TSPO expression is up-regulated in cerebral regions of ob/ob leptin-deficient mice, suggesting a role of the translocator protein in leptin-dependent CNS trophism and metabolism. Unchanged SERT in mutant mice is discussed herein in the context of previous literature as the forerunner to a deeper biochemical investigation.

  12. Ob/ob mouse livers show decreased oxidative phosphorylation efficiencies and anaerobic capacities after cold ischemia.

    Directory of Open Access Journals (Sweden)

    Michael J J Chu

    Full Text Available BACKGROUND: Hepatic steatosis is a major risk factor for graft failure in liver transplantation. Hepatic steatosis shows a greater negative influence on graft function following prolonged cold ischaemia. As the impact of steatosis on hepatocyte metabolism during extended cold ischaemia is not well-described, we compared markers of metabolic capacity and mitochondrial function in steatotic and lean livers following clinically relevant durations of cold preservation. METHODS: Livers from 10-week old leptin-deficient obese (ob/ob, n = 9 and lean C57 mice (n = 9 were preserved in ice-cold University of Wisconsin solution. Liver mitochondrial function was then assessed using high resolution respirometry after 1.5, 3, 5, 8, 12, 16 and 24 hours of storage. Metabolic marker enzymes for anaerobiosis and mitochondrial mass were also measured in conjunction with non-bicarbonate tissue pH buffering capacity. RESULTS: Ob/ob and lean mice livers showed severe (>60% macrovesicular and mild (<30% microvesicular steatosis on Oil Red O staining, respectively. Ob/ob livers had lower baseline enzymatic complex I activity but similar adenosine triphosphate (ATP levels compared to lean livers. During cold storage, the respiratory control ratio and complex I-fueled phosphorylation deteriorated approximately twice as fast in ob/ob livers compared to lean livers. Ob/ob livers also demonstrated decreased ATP production capacities at all time-points analyzed compared to lean livers. Ob/ob liver baseline lactate dehydrogenase activities and intrinsic non-bicarbonate buffering capacities were depressed by 60% and 40%, respectively compared to lean livers. CONCLUSIONS: Steatotic livers have impaired baseline aerobic and anaerobic capacities compared to lean livers, and mitochondrial function indices decrease particularly from after 5 hours of cold preservation. These data provide a mechanistic basis for the clinical recommendation of shorter cold storage durations in

  13. Investigation on steady and unsteady performance of a SCO2 centrifugal compressor with splitters

    Directory of Open Access Journals (Sweden)

    Guo Ding

    2017-01-01

    Full Text Available Supercritical carbon dioxide (SCO2 is widely concerned with its excellent physical properties. Its high density helps to achieve a compact mechanical structure, especially in all kinds of turbomachinery. In this paper, a SCO2 centrifugal compressor with splitter blades is displayed and numerically investigated. A thorough numerical analysis of the steady and unsteady performance of this SCO2 centrifugal compressor is performed in ANSYS-CFX with SST turbulence model. Streamlines, pressure and temperature under steady- and unsteady-state are compared and analyzed. Moreover, the trans-critical phenomenon at the leading edge of the rotor blade and the aerodynamic performance are covered. The results in this paper provide the foundation for the design and numerical investigation of SCO2 centrifugal compressors.

  14. COMPARISON OF S-CO2 POWER CYCLES FOR NUCLEAR ENERGY

    Directory of Open Access Journals (Sweden)

    Ladislav Vesely

    2016-12-01

    Full Text Available The supercritical carbon dioxide (S-CO2 is a possible cooling system for the new generations of nuclear reactors and fusion reactors. The S-CO2 power cycles have several advantages over other possible coolants such as water and helium. The advantages are the compression work, which is lower than in the case of helium, near the critical point and the S-CO2 is more compact than water and helium. The disadvantage is so called Pinch point which occurs in the regenerative heat exchanger. The pinch point can be eliminated by an arrangement of the cycle or using a mixture of CO2. This paper describes the S-CO2 power cycles for nuclear fission and fusion reactors.

  15. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice

    Science.gov (United States)

    The orexigenic hormone ghrelin is important in diabetes because it has an inhibitory effect on insulin secretion. Ghrelin ablation in leptin-deficient ob/ob (Ghrelin(-/-):ob/ob) mice increases insulin secretion and improves hyperglycemia. The physiologically relevant ghrelin receptor is the growth ...

  16. Effect of Uncertainties in CO2 Property Databases on the S-CO2 Compressor Performance

    International Nuclear Information System (INIS)

    Lee, Je Kyoung; Lee, Jeong Ik; Ahn, Yoonhan; Kim, Seong Gu; Cha, Je Eun

    2013-01-01

    Various S-CO 2 Brayton cycle experiment facilities are on the state of construction or operation for demonstration of the technology. However, during the data analysis, S-CO 2 property databases are widely used to predict the performance and characteristics of S-CO 2 Brayton cycle. Thus, a reliable property database is very important before any experiment data analyses or calculation. In this paper, deviation of two different property databases which are widely used for the data analysis will be identified by using three selected properties for comparison, C p , density and enthalpy. Furthermore, effect of above mentioned deviation on the analysis of test data will be briefly discussed. From this deviation, results of the test data analysis can have critical error. As the S-CO 2 Brayton cycle researcher knows, CO 2 near the critical point has dramatic change on thermodynamic properties. Thus, it is true that a potential error source of property prediction exists in CO 2 properties near the critical point. During an experiment data analysis with the S-CO 2 Brayton cycle experiment facility, thermodynamic properties are always involved to predict the component performance and characteristics. Thus, construction or defining of precise CO 2 property database should be carried out to develop Korean S-CO 2 Brayton cycle technology

  17. Creation of the NaSCoRD Database

    Energy Technology Data Exchange (ETDEWEB)

    Denman, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jankovsky, Zachary Kyle [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stuart, William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    This report was written as part of a United States Department of Energy (DOE), Office of Nuclear Energy, Advanced Reactor Technologies program funded project to re-create the capabilities of the legacy Centralized Reliability Database Organization (CREDO) database. The CREDO database provided a record of component design and performance documentation across various systems that used sodium as a working fluid. Regaining this capability will allow the DOE complex and the domestic sodium reactor industry to better understand how previous systems were designed and built for use in improving the design and operations of future loops. The contents of this report include: overview of the current state of domestic sodium reliability databases; summary of the ongoing effort to improve, understand, and process the CREDO information; summary of the initial efforts to develop a unified sodium reliability database called the Sodium System Component Reliability Database (NaSCoRD); and explain both how potential users can access the domestic sodium reliability databases and the type of information that can be accessed from these databases.

  18. Web Content Analysis On Sustainable Campus Operation (SCO Initiatives

    Directory of Open Access Journals (Sweden)

    Razman Ruzaimah

    2017-01-01

    Full Text Available The purpose of this paper is to identify and analyse the current practices implemented in global universities for achieving sustainability throughout campus operations. This study adopted a web content analysis method where 30 international green universities’ websites have been thoroughly examined to identify common initiatives implemented to achieve sustainability through campus operations. The findings are ranked based on the implementation of these initiatives by participating universities. From the websites reviewed, as much as 31 initiatives have been identified as common initiatives frequently implemented by green universities to achieve sustainability in campus operations. It was found that the common initiatives frequently implemented by most of the universities include ‘Provide bin with clearly marked signs to increase the number of recycling items’, and ‘Generate electricity on campus by establishing power generation plants’ with 87% and 83% respectively. This paper fills the gap by presenting the investigation of sustainability initiatives from some of the major green universities internationally. It is suggested that higher education institutions, particularly Malaysian universities, initiate or manage their implementation of sustainable campus operation (SCO initiatives based on the findings of this research.

  19. Leptin differentially regulates STAT3 activation in the ob/ob mice adipose mesenchymal stem cells

    Science.gov (United States)

    Leptin-deficient genetically obese ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Studies have shown that multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute...

  20. Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Zhou Zhou

    2012-12-01

    Full Text Available Abstract Background Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbers, obesity, and inflamm ation. Currently, information is lacking regarding regulation of adipose stem cell numbers as well as leptin-induced inflammation and its signaling pathway in ob/ob mice. Methods Using leptin deficient ob/ob mice, we investigated whether leptin injection into ob/ob mice increases adipose stem cell numbers and adipose tissue inflammatory marker MCP-1 mRNA and secretion levels. We also determined leptin mediated signaling pathways in the adipose stem cells. Results We report here that adipose stem cell number is significantly increased following leptin injection in ob/ob mice and with treatment of isolated stem cells with leptin in vitro. Leptin also up-regulated MCP-1 secretion in a dose- and time-dependent manner. We further showed that increased MCP-1 mRNA levels were due to increased phosphorylation of Signal Transducer and Activator of Transcription 3 (STAT3 Ser727 but not STAT3 Tyr705 phosphorylation, suggesting differential regulation of MCP-1 gene expression under basal and leptin-stimulated conditions in adipose stem cells. Conclusions Taken together, these studies demonstrate that leptin increases adipose stem cell number and differentially activates STAT3 protein resulting in up-regulation of MCP-1 gene expression. Further studies of mechanisms mediating adipose stem cell hyperplasia and leptin signaling in obesity are warranted and may help identify novel anti-obesity target strategies.

  1. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

    Science.gov (United States)

    Sasaki, Mari; Shinozaki, Shohei; Morinaga, Hironobu; Kaneki, Masao; Nishimura, Emi; Shimokado, Kentaro

    2018-07-02

    Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). We observed that ob/ob; iNOS-KO mice were potentiated for the transition from telogen (rest phase) to anagen (growth phase) in the hair cycle compared with iNOS-proficient ob/ob mice. To determine the effect of nitric oxide (NO) on the hair cycle, we administered an iNOS inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) or topically (10% aminoguanidine) in ob/ob mice. We observed that iNOS inhibitors promoted anagen transition in ob/ob mice. Next, we administered an NO donor (S-nitrosoglutathione, GSNO), to test whether NO has the telogen elongation effects. The NO donor was sufficient to induce telogen elongation in wild-type mice. Together, our data indicate that iNOS-derived NO plays a role in telogen elongation under the inflammatory conditions associated with diabetes in mice. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  2. Participation of the SCO in Peacekeeping Activities, Prevention and Settlement of Conflicts

    Directory of Open Access Journals (Sweden)

    Kirill M. Barskiy

    2015-01-01

    Full Text Available Abstract: Shanghai Cooperation Oprganization is a multi-functional interstate regional organizaton. One of the main priorities in the activities of the SCO is a cooperation in providing regional security and stability in the areas of counteraction against terrorism, separatism, extremism, drug tarfficking, other types of trans-border organized crime and against use of information-communication technologies in destructive purposes. There are all grounds to suppose that in forthcoming years the SCO, especially considering broadening the circle of its permanent state-members, will do some steps in direction of practical application of its latent potential in prevention and settlement of conflicts. Development of the SCO own peacekeeping instruments fully corresponds to the character and scales of security threats and tendencies of their evolution on the modern stage. Such a mechanism in arsenal of the SCO could play deterring role regarding latent local conflicts in its zone of responsibility. Obvious «plus» of involving the SCO in the peacekeeping sphere lays in the fact that its key members China and Russia - both are permamnent members of the UN Security Ciuncil, large powers, possessing serious financial capabilities, military and military-technological resources and rich experience of participation in peacekeeping operations. This is exactly Russia and China who would be able to share main responsibility of organization and financing the SCO peacekeeping operations. Emphasis on promoting settlement of conflicts, peacekeeping and strenhthening of confidence in the military sphere could become one of key vectors of converting the SCO into the regional security community and even become a foundation for the new system of security of Eurasia in the future.

  3. Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor.

    Science.gov (United States)

    Liu, Jing; Li, Jie; Dong, Hong; Chen, Yunfu; Wang, Yansheng; Wu, Hang; Li, Changrun; Weaver, David T; Zhang, Lixin; Zhang, Buchang

    2017-07-01

    Lrp/AsnC family regulators have been found in many bacteria as crucial regulators controlling diverse cellular processes. By genomic alignment, we found that SCO3361, an Lrp/AsnC family protein from Streptomyces coelicolor, shared the highest similarity to the SACE_Lrp from Saccharopolyspora erythraea. Deletion of SCO3361 led to dramatic reduction in actinorhodin (Act) production and delay in aerial mycelium formation and sporulation on solid media. Dissection of the mechanism underlying the function of SCO3361 in Act production revealed that it altered the transcription of the cluster-situated regulator gene actII-ORF4 by directly binding to its promoter. SCO3361 was an auto-regulator and simultaneously activated the transcription of its adjacent divergently transcribed gene SCO3362. SCO3361 affected aerial hyphae formation and sporulation of S. coelicolor by activating the expression of amfC, whiB, and ssgB. Phenylalanine and cysteine were identified as the effector molecules of SCO3361, with phenylalanine reducing the binding affinity, whereas cysteine increasing it. Moreover, interactional regulation between SCO3361 and SACE_Lrp was discovered for binding to each other's target gene promoter in this work. Our findings indicate that SCO3361 functions as a pleiotropic regulator controlling secondary metabolism and morphological development in S. coelicolor.

  4. Sequential formation of subgroups in OB associations

    International Nuclear Information System (INIS)

    Elmegreen, B.G.; Lada, C.J.

    1977-01-01

    We reconsider the structure and formation of OB association in view of recent radio and infrared observations of the adjacent molecular clouds. As a result of this reexamination, we propose that OB subgroups are formed in a step-by-step process which involves the propagation of ionization (I) and shock (S) fronts through a molecular cloud complex. OB stars formed at the edge of a molecular cloud drive these I-S fronts into the cloud. A layer of dense neutral material accumulates between the I and S fronts and eventually becomes gravitationally unstable. This process is analyzed in detail. Several arguments concerning the temperature and mass of this layer suggest that a new OB subgroup will form. After approximately one-half million years, these stars will emerge from and disrupt the star-forming layer. A new shock will be driven into the remaining molecular cloud and will initiate another cycle of star formation.Several observed properties of OB associations are shown to follow from a sequential star-forming mechanism. These include the spatial separation and systematic differences in age of OB subgroups in a given association, the regularity of subgroup masses, the alignment of subgroups along the galactic plane, and their physical expansion. Detailed observations of ionization fronts, masers, IR sources, and molecular clouds are also in agreement with this model. Finally, this mechanism provides a means of dissipating a molecular cloud and exposing less massive stars (e.g., T Tauri stars) which may have formed ahead of the shock as part of the original cloud collapsed and fragmented

  5. Manta A New BroadBand OBS

    Science.gov (United States)

    Hello, Y.; Yegikyan, M.; Charvis, P.; Philippe, O.

    2017-12-01

    Manta is a new BroadBand OBS developed at Geoazur and commercialized by Osean. The design is inspired by 3-years autonomy MUG-OBS a Multiparameter Ocean Bottom System which carry a lot of sort of sensor types. As Mug-OBS, Manta-OBS rated 6000m is designed to resist a trawling. All the components are non corrosive such polyethylene, titanium and buoyancy is ensured by syntactic foam. Equipped in standard version with a Trillium compact OBS Manta has an autonomy of 18 months, but can accept on its 4 input channels any kind of signal as low as from an hydrophone or larger from other type of a seismometer or accelerometer. Tri-axial geophones unit (2 Hz or 4.5 Hz ) can replace the seismometer and will expend the lifespan for the instrument. The seismometer is encapsulated in a central well established by four panels of the main structure to protect it from sea current convection and is decoupled from main chassis. An health bulletin is recoverable by acoustic any time to facilitate the installation and during a visit when instrument is deployed. Main parameters for acquisition can be changed by acoustics command from surface at any time. Once at the bottom, release for the main sensor installation is programmed on a timer but controlled by the tilt of the OBS. If the tilt is too important based on programmed limits, sensor will not released automatically, but this can be forced by acoustic command after returning the tilt informations to the boat operator. Manta is equipped with flash light and AIS system for easy location at recovery, and can also send it's position by Iridium satellite in case of an unexpected ascent such caused by a possible trawling if deployed in shallow water. Clock drift calculation is automatically made against GPS time signal once the OBS return at the surface. The recovery of the OBS is initiated by an acoustic command. These new features made Manta a very versatile instrument for monitoring earthquakes.

  6. uvby and JHKL photometry of OB stars in the association Cygnus OB2

    International Nuclear Information System (INIS)

    Torres-Dodgen, A.V.; Carroll, M.; Tapia, M.

    1991-01-01

    We have obtained uvby and JHK photometry of about 80 stars in the association Cygnus OB2 (VI Cygni), including some foreground stars and three infrared sources. We present colour-colour and colour-magnitude diagrams from which we derive the interstellar extinction and approximate spectral types. We confirm that the interstellar extinction law in the direction of Cyg OB2 is similar to the galactic mean. (author)

  7. AK Sco: a tidally induced atmospheric dynamo in a pre-main sequence binary?

    Science.gov (United States)

    Gómez de Castro, A. I.

    2009-02-01

    AK Sco is a unique source: a 10-30 Myrs old pre-main sequence spectroscopic binary composed by two nearly equal F5 stars that at periastron are separated by barely eleven stellar radii so, the stellar magnetospheres fill the Roche lobe at periastron. The orbit is not yet circularized (e = 0.47) and very strong tides are expected. This makes of AK Sco, the ideal laboratory to study the effect of gravitational tides in the stellar magnetic field building up during pre-main sequence evolution. Evidence of this effect is reported in this contribution.

  8. S-CO2 for efficient power generation with energy storage

    OpenAIRE

    Cerio Vera, Marta

    2016-01-01

    Supercritical CO2 (s-CO2) power cycle has gained interest for concentrating solar power (CSP) application in the last decade to overcome the current low efficiency and high costs of the plants. This cycle is a potential option to replace the steam Rankine cycle due to its higher efficiency, more compact turbomachinery and possibility of including heat storage and direct heating. The purpose of this project is to determine the suitability of integrating s-CO2 power cycle into CSP plants with e...

  9. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice.

    Science.gov (United States)

    Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In

    2014-04-01

    Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

  10. Switching performance of OBS network model under prefetched real traffic

    Science.gov (United States)

    Huang, Zhenhua; Xu, Du; Lei, Wen

    2005-11-01

    Optical Burst Switching (OBS) [1] is now widely considered as an efficient switching technique in building the next generation optical Internet .So it's very important to precisely evaluate the performance of the OBS network model. The performance of the OBS network model is variable in different condition, but the most important thing is that how it works under real traffic load. In the traditional simulation models, uniform traffics are usually generated by simulation software to imitate the data source of the edge node in the OBS network model, and through which the performance of the OBS network is evaluated. Unfortunately, without being simulated by real traffic, the traditional simulation models have several problems and their results are doubtable. To deal with this problem, we present a new simulation model for analysis and performance evaluation of the OBS network, which uses prefetched IP traffic to be data source of the OBS network model. The prefetched IP traffic can be considered as real IP source of the OBS edge node and the OBS network model has the same clock rate with a real OBS system. So it's easy to conclude that this model is closer to the real OBS system than the traditional ones. The simulation results also indicate that this model is more accurate to evaluate the performance of the OBS network system and the results of this model are closer to the actual situation.

  11. Deflection routing scheme for GMPLS-based OBS networks

    DEFF Research Database (Denmark)

    Eid, Arafat; Mahmood, Waqar; Alomar, Anwar

    2010-01-01

    Integrating the Generalized Multi-Protocol Label Switching (GMPLS) framework into an Optical Burst Switching (OBS) Control Plane is a promising solution to alleviating most of OBS performance and design issues. However, implementing the already proposed OBS deflection routing schemes is not appli...

  12. Technical Development for S-CO2 Advanced Energy Conversion

    International Nuclear Information System (INIS)

    Anderson, Mark; Ranjan, Devesh; Hassan, Yassin

    2014-01-01

    This report is divided into four parts. First part of the report describes the methods used to measure and model the flow of supercritical carbon dioxide (S-CO 2 ) through annuli and straight-through labyrinth seals. The effects of shaft eccentricity in small diameter annuli were observed for length-to-hydraulic diameter (L/D) ratios of 6, 12, 143, and 235. Flow rates through tooth-cavity labyrinth seals were measured for inlet pressures of 7.7, 10, and 11 MPa with corresponding inlet densities of 325, 475, and 630 kg/m 3 . Various leakage models were compared to this result to describe their applicability in supercritical carbon dioxide applications. Flow rate measurements were made varying tooth number for labyrinth seals of same total length. Second part of the report describes the computational study performed to understand the leakage through the labyrinth seals using Open source CFD package OpenFOAM. Fluid Property Interpolation Tables (FIT) program was implemented in OpenFOAM to accurately model the properties of CO2 required to solve the governing equations. To predict the flow behavior in the two phase dome Homogeneous Equilibrium Model (HEM) is assumed to be valid. Experimental results for plain orifice (L/D ~ 5) were used to show the capabilities of the FIT model implemented in OpenFOAM. Error analysis indicated that OpenFOAM is capable of predicting experimental data within ±10% error with the majority of data close to ±5% error. Following the validation of computational model, effects of geometrical parameters and operating conditions are isolated from each other and a parametric study was performed in two parts to understand their effects on leakage flow. Third part of the report provides the details of the constructed heat exchanger test facility and presents the experimental results obtained to investigate the effects of buoyancy on heat transfer characteristics of Supercritical carbon dioxide in heating mode. Turbulent flows with Reynolds numbers

  13. Alpha-1 adrenoceptors in brown adipose tissue of lean and ob/ob mice

    International Nuclear Information System (INIS)

    Behrens-Zaror, G.; Himms-Hagen, J.

    1986-01-01

    Obese (ob/ob) mice have a low capacity to increase thyroxine 5'-deiodinase (T4 5'-D) in brown adipose tissue (BAT) when exposed to cold. This effect is mediated by alpha-1 (A-1) adrenoceptors. The authors objective was to find out whether BAT of the ob/ob mouse has normal A-1 receptors. Saturation analysis of binding of [3H]-WB4101 at 0.05 nM to 10 μM to crude membrane preparations (100,000 g pellets from Polytron homogenates) using the LIGAND program of Munson and Rodbard, showed two populations of binding sites in BAT of lean (+/+, 11-15 wk old) mice. Acute exposure (12 h, 14 0 C) or acclimation to cold (3 wk, 14 0 C) did not alter affinity or concentration of sites. Displacement with yohimbine and prazosin indicated binding of WB4101 to A-1 receptors. Very young (5 wk) lean (+/.) and obese mice had similar affinity constants (lean 0.13 +/- 0.043 and 34.2 +/- 14.9; obese, 0.12 +/- 0.028 and 20.9 +/- 5.48 nM) and concentrations (lean 22.4 +/- 3.8 and 647 +/- 137; obese, 28.6 +/- 4.6 and 547 +/- 105 fmol/mg protein) of sites. Old (1 yr) mice had high affinity sites similar to those in younger animals (KD lean 0.19 +/- 0.028, obese, 0.25 +/- 0.075; Bmax lean, 60.2 +/- 12.1; obese, 63.1 +/- 13.5 fmol/mg protein). The authors conclude that the ob/ob mouse has normal high affinity A-1 receptors in BAT. Anomalous properties of low affinity binding in old ob/ob mice could not be characterized because of high nonspecific binding. BAT of the ob/ob mouse does not lack A-1 receptors but may have a post-receptor alteration in the A-1 adrenoceptor-mediated response

  14. Experimental and Numerical Analysis of S-CO2 Critical Flow for SFR Recovery System Design

    International Nuclear Information System (INIS)

    Kim, Min Seok; Jung, Hwa-Young; Ahn, Yoonhan; Lee, Jekyoung; Lee, Jeong Ik

    2016-01-01

    This paper presents both numerical and experimental studies of the critical flow of S-CO 2 while special attention is given to the turbo-machinery seal design. A computational critical flow model is described first. The experiments were conducted to validate the critical flow model. Various conditions have been tested to study the flow characteristic and provide validation data for the model. The comparison of numerical and experimental results of S-CO 2 critical flow will be presented. In order to eliminate SWR, a concept of coupling the Supercritical CO 2 (S-CO 2 ) cycle with SFR has been proposed. It is known that for a closed system controlling the inventory is important for stable operation and achieving high efficiency. Since the S-CO 2 power cycle is a highly pressurized system, certain amount of leakage flow is inevitable in the rotating turbo-machinery via seals. To simulate the CO 2 leak flow in a turbo-machinery with higher accuracy in the future, the real gas effect and friction factor will be considered for the CO 2 critical flow model. Moreover, experimentally obtained temperature data were somewhat different from the numerically obtained temperature due to the insufficient insulation and large thermal inertia of the CO 2 critical flow facility. Insulation in connecting pipes and the low-pressure tank will be added and additional tests will be conducted

  15. Rapid Decline in Radio Flux Density of Nova Sco 2015 Followed By Rise at High Frequencies

    Science.gov (United States)

    Linford, J.; Nelson, T.; Chomiuk, L.; Sokoloski, J.; Mukai, K.; Finzell, T.; Weston, J.; Rupen, M.; Mioduszewski, A.

    2015-03-01

    We are monitoring Nova Sco 2015 (PNV J17032620-3504140) at radio wavelengths with the Karl G. Jansky Very Large Array (VLA). We have observations from three epochs: 2015 Feb 14.5, 2015 Feb 18.5-19.5, and 2015 Feb 24.6-Mar 01.5.

  16. Application of S-CO_2 Cycle for Small Modular Reactor coupled with Desalination System

    International Nuclear Information System (INIS)

    Lee, Won Woong; Bae, Seong Jun; Lee, Jeong Ik

    2016-01-01

    The Korean small modular reactor, SMART (System-integrated Modular Advanced ReacTor, 100MWe), is designed to achieve enhanced safety and improved economics through reliable passive safety systems, a system simplification and component modularization. SMART can generate electricity and provide water by seawater desalination. However, due to the desalination aspect of SMART, the total amount of net electricity generation is decreased from 100MWe to 90MWe. The authors suggest in this presentation that the reduction of electricity generation can be replenished by applying S-CO_2 power cycle technology. The S-CO_2 Brayton cycle, which is recently receiving significant attention as the next generation power conversion system, has some benefits such as high cycle efficiency, simple configuration, compactness and so on. In this study, the cycle performance analysis of the S-CO_2 cycles for SMART with desalination system is conducted. The simple recuperated S-CO_2 cycle is revised for coupling with desalination system. The three revised layout are proposed for the cycle performance comparison. In this results of the 3rd revised layout, the cycle efficiency reached 37.8%, which is higher than the efficiency of current SMART with the conventional power conversion system 30%

  17. Genetic relationship and diversity among coconut (Cocos nucifera L.) accessions revealed through SCoT analysis.

    Science.gov (United States)

    Rajesh, M K; Sabana, A A; Rachana, K E; Rahman, Shafeeq; Jerard, B A; Karun, Anitha

    2015-12-01

    Coconut (Cocos nucifera L.) is one of the important palms grown both as a homestead and plantation crop in countries and most island territories of tropical regions. Different DNA-based marker systems have been utilized to assess the extent of genetic diversity in coconut. Advances in genomics research have resulted in the development of novel gene-targeted markers. In the present study, we have used a simple and novel marker system, start codon targeted polymorphism (SCoT), for its evaluation as a potential marker system in coconut. SCoT markers were utilized for assessment of genetic diversity in 23 coconut accessions (10 talls and 13 dwarfs), representing different geographical regions. Out of 25 SCoT primers screened, 15 primers were selected for this study based on their consistent amplification patterns. A total of 102 scorable bands were produced by the 15 primers, 88 % of which were polymorphic. The scored data were used to construct a similarity matrix. The similarity coefficient values ranged between 0.37 and 0.91. These coefficients were utilized to construct a dendrogram using the unweighted pair group of arithmetic means (UPGMA). The extent of genetic diversity observed based on SCoT analysis of coconut accessions was comparable to earlier findings using other marker systems. Tall and dwarf coconut accessions were clearly demarcated, and in general, coconut accessions from the same geographical region clustered together. The results indicate the potential of SCoT markers to be utilized as molecular markers to detect DNA polymorphism in coconut accessions.

  18. Validation of the Persian version of the Schizophrenia Cognition Rating Scale (SCoRS) in patients with schizophrenia.

    Science.gov (United States)

    Mazhari, Shahrzad; Ghafaree-Nejad, Ali R; Soleymani-Zade, Somayeh; Keefe, Richard S E

    2017-06-01

    The Schizophrenia Cognition Rating Scale (SCoRS) is an interview-based assessment of cognition that involves interviews with patients and informants. The SCoRS has shown good reliability, validity, and sensitivity to cognitive impairment in schizophrenia, with the advantage of brief administration and scoring time. The present study aimed to test the concurrent validity of the Persian version of the SCoRS. A group of 35 patients with schizophrenia and a group of 35 healthy controls received the Persian-SCoRS in the first session, and a standardized performance-based cognitive battery, the Brief Assessment of Cognition in Schizophrenia (BACS), in the second session.Our results indicated that the Persian version of the SCoRS was sensitive to cognitive impairment in the patients. The Persian SCoRS global rating was significantly associated with the composite score generated from the Persian version of the BACS and predicted functional outcomes as measured by Global Assessment of Functioning (GAF) and World Health Organization Quality of Life (WHO QOL). A Persian version of the SCoRS, an interview based measure of cognition that included informants, is related to cognitive performance and global functioning. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes.

    Science.gov (United States)

    Wei, Xiang-Bo; Guo, Liang; Liu, Yang; Zhou, Shui-Rong; Liu, Yuan; Dou, Xin; Du, Shao-Yue; Ding, Meng; Peng, Wan-Qiu; Qian, Shu-Wen; Huang, Hai-Yan; Tang, Qi-Qun

    2017-09-23

    Dysregulation of insulin signaling leads to type 2 diabetes mellitus (T2DM) and other metabolic disorders. Obesity is an important contributor to insulin resistance, and although the understanding of this relationship has improved in recent years, the mechanism of obesity-induced insulin resistance is not completely understood. Disorders of copper metabolism tend to accompany the development of obesity, which increases the risk of insulin resistance. Synthesis of cytochrome c oxidase 1 (SCO1) functions in the assembly of cytochrome c oxidase (COX) and cellular copper homeostasis. However, the role of SCO1 in the regulation of metabolism remains unknown. Here, we found that obese mice had higher expression of SCO1 and lower levels of copper in white adipose tissue (WAT) than did the control mice. Overexpression of SCO1 in adipocytes was associated with copper deficiency. Copper increased insulin sensitivity by decreasing the level of phosphatase and tensin homolog (PTEN) protein. Ectopic expression of SCO1 led to insulin resistance and was accompanied by a decrease in intracellular copper level, and addition of copper abolished the inhibitory effect of SCO1 on insulin sensitivity. Our results demonstrated a novel role of SCO1 in modulating insulin sensitivity via the regulation of copper concentration in WAT and suggested a potential therapeutic target for T2DM. Copyright © 2017. Published by Elsevier Inc.

  20. Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

    OpenAIRE

    Choi, Ha-Neul; Jang, Yang-Hee; Kim, Min-Joo; Seo, Min Jeong; Kang, Byoung Won; Jeong, Yong Kee; Kim, Jung-In

    2014-01-01

    BACKGROUND/OBJECTIVES Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free...

  1. Preliminary study of Friction disk type turbine for S-CO_2 cycle application (2016 Autumn Meeting of the KNS)

    International Nuclear Information System (INIS)

    Baik, Seungjoon; Heo, Jin Young; Kwon, Jinsu; Lee, Jeong Ik

    2016-01-01

    Among the next generation reactors, a sodium-cooled fast reactor (SFR) with the supercritical carbon dioxide (S-CO_2) Brayton cycle has been suggested as the advanced energy solution. The S-CO_2 power conversion system can achieve high efficiency with the SFR core thermal condition (450-550℃) and also can reduce the total cycle footprint due to high density of the working fluid. Moreover, the S-CO_2 power cycle can reduce the accident consequence compared to the steam Rankine cycle due to the mild sodium-CO_2 interaction. The S-CO_2 power cycle has different characteristic compare to the conventional steam Rankine cycle or gas Brayton cycle. For the turbine section, the expansion ratio is much smaller than the other cycles. Thus, different type of turbine should be evaluated for the advanced S-CO_2 technology and the KAIST research team considered a friction disk type turbine (Tesla turbine) concept for the S-CO_2 cycle applications. In this paper, the test result and analysis of a lab-scale Tesla turbine in the KAIST S-CO_2 experimental facility (S-CO_2PE) are briefly discussed. The KAIST research team investigated a friction disk type turbine, named as Tesla turbine, for the S-CO_2 power cycle applications. The preliminary test of a lab-scale Tesla turbine was conducted with compressed air. The generator, nozzle angle and bearing performances are tested. With the best performing nozzle angle and bearing, the Tesla turbine was tested under various S-CO_2 conditions. As a result, the S-CO_2PE facility generated electricity (0.5-5W). The isentropic efficiency was relatively low (0.8-1.3%). It seemed that, the authors need further study to understand the main mechanism and maximize the efficiency. After developing the design methodology, the design optimization will be conducted to show the applicability of the friction disk type turbine for the S-CO_2 power cycle

  2. Automated identification of OB associations in M31

    Science.gov (United States)

    Magnier, Eugene A.; Battinelli, Paolo; Lewin, Walter H. G.; Haiman, Zoltan; Paradijs, Jan Van; Hasinger, Guenther; Pietsch, Wolfgang; Supper, Rodrigo; Truemper, Joachim

    1993-01-01

    A new identification of OB associations in M31 has been performed using the Path Linkage Criterion (PLC) technique of Battinelli (1991). We found 174 associations with a very small contamination (less than 5%) by random clumps of stars. The expected total number and average size of OB associations in the region of M 31 covered by our data set (Magnier et al. 1992) are approximately 280 and approximately 90 pc, respectively. M31 associations therefore have sizes similar to those of OB associations observed in nearby galaxies, so that we can consider them to be classical OB associations. This list of OB associations will be used for the study of the spatial distribution of OB associations and their correlation with other objects. Taking into account the fact that we do not cover the entire disk of M31, we extrapolate a total number of association in M31 of approximately 420.

  3. COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice.

    Directory of Open Access Journals (Sweden)

    Joanna Kosacka

    Full Text Available BACKGROUND: Leptin-deficient ob/ob mice are a model of type 2 diabetes induced peripheral neuropathy. Ob/ob mice exhibit obesity, insulin resistance, hyperglycaemia, and alterations of peripheral nerve fibres and endoneural microvessels. Here we test the hypothesis that cartilage oligomeric matrix protein (COMP-Ang-1, a soluble and stabile form of Ang-1 which promotes angiogenesis and nerve growth, improves regeneration of nerve fibres and endoneural microvessels in ob/ob mice. METHODS AND FINDINGS: COMP-Ang-1 (100 ng/ml or NaCl were intraperitoneally (i.p. injected into male (N = 184, 3-month old, ob/ob or ob/+ mice for 7 and 21 days. We measured expression of Nf68, GAP43, Cx32, Cx26, Cx43, and TNFα in sciatic nerves using Western blot analysis. To investigate the inflammation in sciatic nerves, numbers of macrophages and T-cells were counted after immunofluorescence staining. In ultrathin section, number of myelinated/non-mylinated nerve fibers, g-ratio, the thickness of Schwann cell basal lamina and microvessel endothelium were investigated. Endoneural microvessels were reconstructed with intracardial FITC injection. Treatment with COMP-Ang-1 over 21 days significantly reduced fasting blood glucose and plasma cholesterol concentrations compared to saline treated ob/ob mice. In addition, COMP-Ang-1 treatment: 1 up-regulated expression of Nf68 and GAP43; 2 improved expression of gap junction proteins including connexin 32 and 26; 3 suppressed the expression of TNFα and Cx43 and 4 led to decreased macrophage and T-cell infiltration in sciatic nerve of ob/ob mice. The significant changes of sciatic nerve ultrastructure were not observed after 21-day long COMP-Ang-1 treatment. COMP-Ang-1 treated ob/ob mice displayed regeneration of small-diameter endoneural microvessels. Effects of COMP-Ang-1 corresponded to increased phosphorylation of Akt and p38 MAPK upon Tie-2 receptor. CONCLUSIONS: COMP-Ang-1 recovers molecular biomarkers of neuropathy

  4. Radial-velocity variations in Alpha Ori, Alpha Sco, and Alpha Her

    International Nuclear Information System (INIS)

    Smith, M.A.; Patten, B.M.; Goldberg, L.

    1989-01-01

    Radial-velocity observations of Alpha Ori, Alpha Sco A, and Alpha Her A are used to study radial-velocity periodicities in M supergiants. The data refer to several metallic lines in the H-alpha region and to H-alpha itself. It is shown that Alpha Ori and Alpha Sco A have cycle lengths of about 1 yr and semiamplitudes of 2 km/s. It is suggested that many semiregular red supergiant varibles such as Alpha Ori may be heading toward chaos. All three stars show short-term stochastic flucutations with an amplitude of 1-2 km/s. It is found that the long-term variability of H-alpha velocities may be a consequence of intermittent failed ejections. 58 refs

  5. Preliminary Design of S-CO2 Brayton Cycle for KAIST Micro Modular Reactor

    International Nuclear Information System (INIS)

    Kim, Seong Gu; Kim, Min Gil; Bae, Seong Jun; Lee, Jeong Ik

    2013-01-01

    This paper suggests a complete modular reactor with an innovative concept of reactor cooling by using a supercritical carbon dioxide directly. Authors propose the supercritical CO 2 Brayton cycle (S-CO 2 cycle) as a power conversion system to achieve small volume of power conversion unit (PCU) and to contain the core and PCU in one vessel for the full modularization. This study suggests a conceptual design of small modular reactor including PCU which is named as KAIST Micro Modular Reactor (MMR). As a part of ongoing research of conceptual design of KAIST MMR, preliminary design of power generation cycle was performed in this study. Since the targets of MMR are full modularization of a reactor system with S-CO 2 coolant, authors selected a simple recuperated S-CO 2 Brayton cycle as a power conversion system for KAIST MMR. The size of components of the S-CO 2 cycle is much smaller than existing helium Brayton cycle and steam Rankine cycle, and whole power conversion system can be contained with core and safety system in one containment vessel. From the investigation of the power conversion cycle, recompressing recuperated cycle showed higher efficiency than the simple recuperated cycle. However the volume of heat exchanger for recompressing cycle is too large so more space will be occupied by heat exchanger in the recompressing cycle than the simple recuperated cycle. Thus, authors consider that the simple recuperated cycle is more suitable for MMR. More research for the KAIST MMR will be followed in the future and detailed information of reactor core and safety system will be developed down the road. More refined cycle layout and design of turbomachinery and heat exchanger will be performed in the future study

  6. Study of the cooling systems with S-CO2 for the DEMO fusion power reactor.

    Czech Academy of Sciences Publication Activity Database

    Veselý, L.; Dostál, V.; Entler, Slavomír

    2017-01-01

    Roč. 124, November (2017), s. 244-247 ISSN 0920-3796. [SOFT 2016: Symposium on Fusion Technology /29./. Prague, 05.09.2016-09.09.2016] Institutional support: RVO:61389021 Keywords : DEMO * Cooling * Energy conversion * Thermal cycle * Carbon dioxide * SCO2a Subject RIV: JF - Nuclear Energetics OBOR OECD: Nuclear related engineering Impact factor: 1.319, year: 2016 http://www.sciencedirect.com/science/article/pii/S0920379617305719

  7. The study of triple systems V949 Cen, V358 Pup and V1055 Sco

    Czech Academy of Sciences Publication Activity Database

    Zasche, P.; Hoňková, K.; Juryšek, Jakub; Mašek, Martin

    2015-01-01

    Roč. 65, č. 2 (2015), s. 151-168 ISSN 0001-5237 R&D Projects: GA MŠk(CZ) LG13007 EU Projects: European Commission(XE) 283783 - GLORIA Institutional support: RVO:68378271 Keywords : eclipsing binaries * V949 Cen * V358 Pup * V1055 Sco Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 2.000, year: 2015

  8. Multiple containment for LSA [low specific activity] and SCO [surface contaminated objects] wastes

    International Nuclear Information System (INIS)

    Burgess, M.H.

    1993-09-01

    Radioactive wastes are generally transported in the form of Low Specific Activity (LSA) materials or Surface Contaminated Objects (SCO). This report proposes that a method of acknowledging the beneficial effects of multiple containment for such wastes should be written into the 1996 Edition of the IAEA Transport Regulations. Experience used to assess risks from on-site movements of radioactive material in the UK can be applied to develop safety arguments justifying the alleviation of off-site transport risks. (UK)

  9. Cycle layout studies of S-CO2 cycle for the next generation nuclear system application

    International Nuclear Information System (INIS)

    Ahn, Yoonhan; Bae, Seong Jun; Kim, Minseok; Cho, Seong Kuk; Baik, Seungjoon; Lee, Jeong Ik; Cha, Jae Eun

    2014-01-01

    According to the second law of thermodynamics, the next generation nuclear reactor system efficiency can potentially be increased with higher operating temperature. Fig.1 shows several power conversion system efficiencies and heat sources with respect to the system top operating temperature. As shown in Fig.1, the steam Rankine and gas Brayton cycles have been considered as the major power conversion systems more than several decades. In the next generation reactor operating temperature region (450 - 900 .deg. C), the steam Rankine and gas Brayton cycles have limits due to material problems and low efficiency, respectively. Among the future power conversion systems, S-CO 2 cycle is receiving interests due to several benefits including high efficiency under the mild turbine inlet temperature range (450-650 .deg. C), compact turbomachinery and simple layout compared to the steam Rankine cycle. S-CO 2 cycle can show relatively high efficiency under the mild turbine inlet temperature range (450-600 .deg. C) compared to other power conversion systems. The recompression cycle shows the best efficiency among other layouts and it is suitable for the application to advanced nuclear reactor systems. As S-CO 2 cycle performance can vary depending on the layout configuration, further studies on the layouts are required to design a better performing cycle

  10. Passive Decay Heat Removal System Options for S-CO2 Cooled Micro Modular Reactor

    International Nuclear Information System (INIS)

    Moon, Jangsik; Jeong, Yong Hoon; Lee, Jeong Ik

    2014-01-01

    To achieve modularization of whole reactor system, Micro Modular Reactor (MMR) which has been being developed in KAIST took S-CO 2 Brayton power cycle. The S-CO 2 power cycle is suitable for SMR due to high cycle efficiency, simple layout, small turbine and small heat exchanger. These characteristics of S-CO 2 power cycle enable modular reactor system and make reduced system size. The reduced size and modular system motived MMR to have mobility by large trailer. Due to minimized on-site construction by modular system, MMR can be deployed in any electricity demand, even in isolated area. To achieve the objective, fully passive safety systems of MMR were designed to have high reliability when any offsite power is unavailable. In this research, the basic concept about MMR and Passive Decay Heat Removal (PDHR) system options for MMR are presented. LOCA, LOFA, LOHS and SBO are considered as DBAs of MMR. To cope with the DBAs, passive decay heat removal system is designed. Water cooled PDHR system shows simple layout, but has CCF with reactor systems and cannot cover all DBAs. On the other hand, air cooled PDHR system with two-phase closed thermosyphon shows high reliability due to minimized CCF and is able to cope with all DBAs. Therefore, the PDHR system of MMR will follows the air-cooled PDHR system and the air cooled system will be explored

  11. SCoT marker for the assessment of genetic diversity in saudi arabian date palm cultivars

    International Nuclear Information System (INIS)

    Qurainy, F.A.; Tarroum, M.

    2015-01-01

    Different types of molecular markers based on DNA have been used for the assessment of genetic diversity in the plant species. Start Codon Targeted Polymorphism (SCoT) marker has recently become the marker of choice in genetic diversity studies. SCoT marker was used for the assessment of genetic diversity in Saudi Arabian date palm cultivars. The percentage of polymorphic loci (PPL) at population level ranged from 3.28 to 13.11 with an average of 7.10. The Neis gene diversity (h) and Shannons Information index (I) were 0.033 and 0.046, respectively. However, at cultivar level, PPL, Neis gene diversity (h) and Shannons Information index (I) were 42.62, 0.090 and 0.155, respectively. Analysis of molecular variance (AMOVA) showed 48% of variation within the populations, whereas 52% was found among the populations. A hierarchical analysis of molecular variance revealed level of genetic differentiation among populations (52% of total variance, P = 0.001), consistent with the gene differentiation coefficient (Gst = 0.631). Unweighted pair group method of arithmetic averages (UPGMA) cluster analysis of the SCoT marker data divided the six cultivars and their populations into five main clusters at 0.95 genetic similarity coefficient level. (author)

  12. Potential of Start Codon Targeted (SCoT) markers for DNA fingerprinting of newly synthesized tritordeums and their respective parents.

    Science.gov (United States)

    Cabo, Sandra; Ferreira, Luciana; Carvalho, Ana; Martins-Lopes, Paula; Martín, António; Lima-Brito, José Eduardo

    2014-08-01

    Hexaploid tritordeum (H(ch)H(ch)AABB; 2n = 42) results from the cross between Hordeum chilense (H(ch)H(ch); 2n = 14) and cultivated durum wheat (Triticum turgidum ssp. durum (AABB; 2n = 28). Morphologically, tritordeum resembles the wheat parent, showing promise for agriculture and wheat breeding. Start Codon Targeted (SCoT) polymorphism is a recently developed technique that generates gene-targeted markers. Thus, we considered it interesting to evaluate its potential for the DNA fingerprinting of newly synthesized hexaploid tritordeums and their respective parents. In this study, 60 SCoT primers were tested, and 18 and 19 of them revealed SCoT polymorphisms in the newly synthesized tritordeum lines HT27 and HT22, respectively, and their parents. An analysis of the presence/absence of bands among tritordeums and their parents revealed three types of polymorphic markers: (i) shared by tritordeums and one of their parents, (ii) exclusively amplified in tritordeums, and (iii) exclusively amplified in the parents. No polymorphism was detected among individuals of each parental species. Three SCoT markers were exclusively amplified in tritordeums of lines HT22 and HT27, being considered as polyploidization-induced rearrangements. About 70% of the SCoT markers of H. chilense origin were not transmitted to the allopolyploids of both lines, and most of the SCoTs scored in the newly synthesized allopolyploids originated from wheat, reinforcing the potential use of tritordeum as an alternative crop.

  13. Enhanced glucose cycling and suppressed de novo synthesis of glucose-6-phosphate result in a net unchanged hepatic glucose output in ob/ob mice

    NARCIS (Netherlands)

    Bandsma, RHJ; Grefhorst, A; van Dijk, TH; van der Sluijs, FH; Hammer, A; Reijngoud, DJ; Kuipers, F

    2004-01-01

    Aims/hypothesis. Leptin-deficient ob/ob mice are hyperinsulinaemic and hyperglycaemic; however, the cause of hyperglycaemia remains largely unknown. Methods. Glucose metabolism in vivo in 9-h fasted ob/ob mice and lean littermates was studied by infusing [U-C-13]-glucose, [2-C-13]-glycerol,

  14. Leptin Increases Striatal Dopamine D2 Receptor Binding in Leptin-Deficient Obese (ob/ob) Mice

    Energy Technology Data Exchange (ETDEWEB)

    Pfaffly, J.; Michaelides, M.; Wang, G-J.; Pessin, J.E.; Volkow, N.D.; Thanos, P.K.

    2010-06-01

    Peripheral and central leptin administration have been shown to mediate central dopamine (DA) signaling. Leptin-receptor deficient rodents show decreased DA D2 receptor (D2R) binding in striatum and unique DA profiles compared to controls. Leptin-deficient mice show increased DA activity in reward-related brain regions. The objective of this study was to examine whether basal D2R-binding differences contribute to the phenotypic behaviors of leptin-deficient ob/ob mice, and whether D2R binding is altered in response to peripheral leptin treatment in these mice. Leptin decreased body weight, food intake, and plasma insulin concentration in ob/ob mice but not in wild-type mice. Basal striatal D2R binding (measured with autoradiography [{sup 3}H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. Our findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.

  15. Molecular characterization of Streptomyces coelicolor A(3) SCO6548 as a cellulose 1,4-β-cellobiosidase.

    Science.gov (United States)

    Lim, Ju-Hyeon; Lee, Chang-Ro; Dhakshnamoorthy, Vijayalakshmi; Park, Jae Seon; Hong, Soon-Kwang

    2016-02-01

    Genomic sequencing analysis and previous studies have shown that there are eight genes in Streptomyces coelicolor A3(2) encoding putative cellulases. One of these genes, sco6548, was cloned into the Streptomyces/Escherichia coli shuttle vector pUWL201PW. The recombinant protein was successfully overexpressed in S. lividans TK24 under the control of the strong ermE promoter. Sco6548 was 1740 bp in length, and encoded a 579-amino acid-, 60.8-kDa protein with strong hydrolyzing activity toward Avicel and filter paper, yielding cellobiose as the final product. SCO6548 showed optimal activity at 50°C and pH 5. The Km values of SCO6548 toward Avicel and filter paper were 15.38 and 16.1 mg/mL, respectively. The Vmax values toward Avicel and filter paper were 0.432 and 0.084 μM/min, respectively. EDTA did not affect cellulase activity; however, several divalent cations, including Co(2+), Cu(2+), Ni(2+) and Mn(2+) (at 10 mM) had severe inhibitory effects on enzyme activity. Our analysis showed that SCO6548 is a cellulose 1,4-β-cellobiosidase that hydrolyzes cellulose into cellobiose. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Start codon targeted (SCoT) and target region amplification polymorphism (TRAP) for evaluating the genetic relationship of Dendrobium species.

    Science.gov (United States)

    Feng, Shangguo; He, Refeng; Yang, Sai; Chen, Zhe; Jiang, Mengying; Lu, Jiangjie; Wang, Huizhong

    2015-08-10

    Two molecular marker systems, start codon targeted (SCoT) and target region amplification polymorphism (TRAP), were used for genetic relationship analysis of 36 Dendrobium species collected from China. Twenty-two selected SCoT primers produced 337 loci, of which 324 (96%) were polymorphic, whereas 13 TRAP primer combinations produced a total of 510 loci, with 500 (97.8%) of them being polymorphic. An average polymorphism information content of 0.953 and 0.983 was detected using the SCoT and TRAP primers, respectively, showing that a high degree of genetic diversity exists among Chinese Dendrobium species. The partition of clusters in the unweighted pair group method with arithmetic mean dendrogram and principal coordinate analysis plot based on the SCoT and TRAP markers was similar and clustered the 36 Dendrobium species into four main groups. Our results will provide useful information for resource protection and will also be useful to improve the current Dendrobium breeding programs. Our results also demonstrate that SCoT and TRAP markers are informative and can be used to evaluate genetic relationships between Dendrobium species. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Infrared observations and mass loss of the binary system V861 Sco

    International Nuclear Information System (INIS)

    Tanzi, E.G.; Maraschi, L.; Tarenghi, M.; Treves, A.

    1981-01-01

    V 861 Sco (HD 152667) is a well known single line binary. The proposed association with a variable X-ray source has triggered renewed interest in the system. Here the authors report on a series of photometric observations in the infrared (from 1.25 to 4.8 μ) taken at various orbital phases which improve and extend previous measurements by Tanzi et al. The results give evidence of a phase modulated infrared excess which can be interpreted in terms of a non isotropic mass flow in the system or, alternately, of a contribution from a colder secondary component. (Auth.)

  18. Solution structure of the major fish allergen parvalbumin Sco j 1 derived from the Pacific mackerel

    OpenAIRE

    Kumeta, Hiroyuki; Nakayama, Haruka; Ogura, Kenji

    2017-01-01

    Although fish is an important part of the human diet, it is also a common source of food allergy. The major allergen in fish is parvalbumin, a well-conserved Ca2+-binding protein found in the white muscle of many fish species. Here, we studied the solution structure of the parvalbumin Sco j 1, derived from the Pacific mackerel, using nuclear magnetic resonance spectroscopy. We mapped the IgE-binding epitope proposed in a recent study onto the present structure. Interestingly, three of four re...

  19. Reverse time migration of multiples for OBS data

    KAUST Repository

    Zhang, Dongliang

    2014-01-01

    Reverse time migration of multiples (RTMM) is applied to OBS data with sparse receiver spacing. RTMM for OBS data unlike a marine streamer acquisition is implemented in the common receiver gathers (CRG) and provides a wider and denser illumination for each CRG than the conventional RTM of primaries. Hence, while the the conventional RTM image contains strong aliasing artifacts due to a sparser receiver interval, the RTMM image suffers from this artifacts less. This benefit of RTMM is demonstrated with numerical test on the Marmousi model for sparsely sampled OBS data.

  20. Searching for self-enrichment in Cygnus OB2

    Science.gov (United States)

    Berlanas, Sara R.; Herrero, Artemio; Comerón, Fernando; Pasquali, Anna; Simón-Díaz, Sergio

    2017-11-01

    Cygnus OB2 is a rich and relatively close (d~1.4 kpc) OB association in our Galaxy. It represents an ideal testbed for our theories about self-enrichment processes produced by pollution of the interstellar medium by successive generations of massive stars. Comerón & Pasquali (2012, A&A, 543, A101) found a correlation between the age of young stellar groups in Cygnus OB2 and their Galactic longitude. If is associated with a chemical composition gradient, it could support these self-enrichment processes.

  1. Reverse time migration of multiples for OBS data

    KAUST Repository

    Zhang, Dongliang

    2014-08-05

    Reverse time migration of multiples (RTMM) is applied to OBS data with sparse receiver spacing. RTMM for OBS data unlike a marine streamer acquisition is implemented in the common receiver gathers (CRG) and provides a wider and denser illumination for each CRG than the conventional RTM of primaries. Hence, while the the conventional RTM image contains strong aliasing artifacts due to a sparser receiver interval, the RTMM image suffers from this artifacts less. This benefit of RTMM is demonstrated with numerical test on the Marmousi model for sparsely sampled OBS data.

  2. A Novel Congestion Detection Scheme in TCP Over OBS Networks

    KAUST Repository

    Shihada, Basem; Ho, Pin-Han; Zhang, Qiong

    2009-01-01

    This paper introduces a novel congestion detection scheme for high-bandwidth TCP flows over optical burst switching (OBS) networks, called statistical additive increase multiplicative decrease (SAIMD). SAIMD maintains and analyzes a number

  3. 18 Sco: A solar twin rich in refractory and neutron-capture elements. Implications for chemical tagging

    Energy Technology Data Exchange (ETDEWEB)

    Meléndez, Jorge; Monroe, TalaWanda R.; Tucci Maia, Marcelo; Freitas, Fabrício C. [Departamento de Astronomia do IAG/USP, Universidade de São Paulo, Rua do Matão 1226, 05508-900 São Paulo, SP (Brazil); Ramírez, Iván [McDonald Observatory and Department of Astronomy, University of Texas at Austin (United States); Karakas, Amanda I.; Yong, David; Asplund, Martin [Research School of Astronomy and Astrophysics, The Australian National University, Cotter Road, Weston, ACT 2611 (Australia); Bedell, Megan; Bean, Jacob [Department of Astronomy and Astrophysics, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637 (United States); Bergemann, Maria [Institute of Astronomy, University of Cambridge, Madingley Road, CB3 0HA, Cambridge (United Kingdom); Do Nascimento, José-Dias Jr.; Castro, Matthieu [Departamento de Física Teórica e Experimental, Universidade Federal do Rio Grande do Norte, 59072-970 Natal, RN (Brazil); Bazot, Michael [Centro de Astrofísica da Universidade do Porto, Rua das Estrelas, 4150-762 Porto (Portugal); Alves-Brito, Alan, E-mail: jorge.melendez@iag.usp.br [Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Av. Bento Goncalves 9500, Porto Alegre, RS (Brazil)

    2014-08-10

    We study with unprecedented detail the chemical composition and stellar parameters of the solar twin 18 Sco in a strictly differential sense relative to the Sun. Our study is mainly based on high-resolution (R ∼ 110,000), high signal-to-noise ratio (800-1,000) Very Large Telescope UVES spectra, which allow us to achieve a precision of about 0.005 dex in differential abundances. The effective temperature and surface gravity of 18 Sco are T{sub eff} = 5823 ± 6 K and log g = 4.45 ± 0.02 dex, i.e., 18 Sco is 46 ± 6 K hotter than the Sun and log g is 0.01 ± 0.02 dex higher. Its metallicity is [Fe/H] = 0.054 ± 0.005 dex, and its microturbulence velocity is +0.02 ± 0.01 km s{sup –1} higher than solar. Our precise stellar parameters and differential isochrone analysis show that 18 Sco has a mass of 1.04 ± 0.02 M{sub ☉} and that it is ∼1.6 Gyr younger than the Sun. We use precise High Accuracy Radial velocity Planet Searcher (HARPS) radial velocities to search for planets, but none are detected. The chemical abundance pattern of 18 Sco displays a clear trend with condensation temperature, thus showing higher abundances of refractories in 18 Sco than in the Sun. Intriguingly, there are enhancements in the neutron-capture elements relative to the Sun. Despite the small element-to-element abundance differences among nearby n-capture elements (∼0.02 dex), we successfully reproduce the r-process pattern in the Solar System. This is independent evidence for the universality of the r process. Our results have important implications for chemical tagging in our Galaxy and nucleosynthesis in general.

  4. Stratospheric controlled perturbation experiment (SCoPEx): overview, status, and results from related laboratory experiments

    Science.gov (United States)

    Keith, D.; Dykema, J. A.; Keutsch, F. N.

    2017-12-01

    Stratospheric Controlled Perturbation Experiment (SCoPEx), is a scientific experiment to advance understanding of stratospheric aerosols. It aims to make quantitative measurements of aerosol microphysics and atmospheric chemistry to improve large-scale models used to assess the risks and benefits of solar geoengineering. A perturbative experiment requires: (a) means to create a well-mixed, small perturbed volume, and (b) observation of time evolution of chemistry and aerosols in the volume. SCoPEx will used a propelled balloon gondola containing all instruments and drive system. The propeller wake forms a well-mixed volume (roughly 1 km long and 100 meters in diameter) that serves as an experimental `beaker' into which aerosols (e.g., budget, etc; (d) results from CFD simulation of propeller wake and simulation of chemistry and aerosol microphysics; and finally (e) proposed concept of operations and schedule. We will also provide an overview of the plans for governance including management of health safety and environmental risks, transparency, public engagement, and larger questions about governance of solar geoengineering experiments. Finally, we will briefly present results of laboratory experiments of the interaction of chemical such as ClONO2 and HCl on particle surfaces relevant for stratospheric solar geoengineering.

  5. CONCURRENT FORMATION OF CARBON AND SILICATE DUST IN NOVA V1280 SCO

    Energy Technology Data Exchange (ETDEWEB)

    Sakon, Itsuki; Onaka, Takashi; Usui, Fumihiko [Department of Astronomy, Graduate Schools of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Sako, Shigeyuki; Takahashi, Hidenori; Ohsawa, Ryou [Institute of Astronomy, University of Tokyo, 2-21-1 Ohsawa, Mitaka, Tokyo 181-0015 (Japan); Nozawa, Takaya [National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588 (Japan); Kimura, Yuki [Institute of Low Temperature Science, Hokkaido University, Sapporo 060-0819 (Japan); Fujiyoshi, Takuya [Subaru Telescope, National Astronomical Observatory of Japan, 650 North A’ohoku Place, Hilo, HI 96720 (United States); Shimonishi, Takashi [Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Aramaki aza Aoba 6-3, Aoba-ku, Sendai 980-8578 (Japan); Arai, Akira [Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto, 603-8555 (Japan); Uemura, Makoto [Hiroshima Astrophysical Science Center, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526 (Japan); Nagayama, Takahiro [Department of Physics and Astronomy, Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Koo, Bon-Chul [Department of Physics and Astronomy, Seoul National University , 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (Korea, Republic of); Kozasa, Takashi, E-mail: isakon@astron.s.u-tokyo.ac.jp [Department of Cosmosciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810 (Japan)

    2016-02-01

    We present infrared multi-epoch observations of the dust-forming nova V1280 Sco over ∼2000 days from the outburst. The temporal evolution of the infrared spectral energy distributions at 1272, 1616, and 1947 days can be explained by the emissions produced by amorphous carbon dust of mass (6.6–8.7) × 10{sup −8} M{sub ⊙} with a representative grain size of 0.01 μm and astronomical silicate dust of mass (3.4–4.3) × 10{sup −7} M{sub ⊙} with a representative grain size of 0.3–0.5 μm. Both of these dust species travel farther away from the white dwarf without apparent mass evolution throughout those later epochs. The dust formation scenario around V1280 Sco suggested from our analyses is that the amorphous carbon dust is formed in the nova ejecta followed by the formation of silicate dust either in the expanding nova ejecta or as a result of the interaction between the nova wind and the circumstellar medium.

  6. DETECTION OF SHARP SYMMETRIC FEATURES IN THE CIRCUMBINARY DISK AROUND AK Sco

    International Nuclear Information System (INIS)

    Janson, Markus; Asensio-Torres, Ruben; Thalmann, Christian; Meyer, Michael R.; Garufi, Antonio; Boccaletti, Anthony; Maire, Anne-Lise; Henning, Thomas; Pohl, Adriana; Zurlo, Alice; Marzari, Francesco; Carson, Joseph C.; Augereau, Jean-Charles; Desidera, Silvano

    2016-01-01

    The Search for Planets Orbiting Two Stars survey aims to study the formation and distribution of planets in binary systems by detecting and characterizing circumbinary planets and their formation environments through direct imaging. With the SPHERE Extreme Adaptive Optics instrument, a good contrast can be achieved even at small (<300 mas) separations from bright stars, which enables studies of planets and disks in a separation range that was previously inaccessible. Here, we report the discovery of resolved scattered light emission from the circumbinary disk around the well-studied young double star AK Sco, at projected separations in the ∼13–40 AU range. The sharp morphology of the imaged feature is surprising, given the smooth appearance of the disk in its spectral energy distribution. We show that the observed morphology can be represented either as a highly eccentric ring around AK Sco, or as two separate spiral arms in the disk, wound in opposite directions. The relative merits of these interpretations are discussed, as well as whether these features may have been caused by one or several circumbinary planets interacting with the disk

  7. DETECTION OF SHARP SYMMETRIC FEATURES IN THE CIRCUMBINARY DISK AROUND AK Sco

    Energy Technology Data Exchange (ETDEWEB)

    Janson, Markus; Asensio-Torres, Ruben [Department of Astronomy, Stockholm University, AlbaNova University Center, SE-106 91 Stockholm (Sweden); Thalmann, Christian; Meyer, Michael R.; Garufi, Antonio [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Boccaletti, Anthony [LESIA, Observatoire de Paris—Meudon, CNRS, Université Pierre et Marie Curie, Université Paris Didierot, 5 Place Jules Janssen, F-92195 Meudon (France); Maire, Anne-Lise; Henning, Thomas; Pohl, Adriana [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Zurlo, Alice [Núcleo de Astronomía, Facultad de Ingeniería, Universidad Diego Portales, Av. Ejercito 441, Santiago (Chile); Marzari, Francesco [Dipartimento di Fisica, University of Padova, Via Marzolo 8, I-35131 Padova (Italy); Carson, Joseph C. [Department of Physics and Astronomy, College of Charleston, 66 George Street, Charleston, SC 29424 (United States); Augereau, Jean-Charles [Université Grenoble Alpes, IPAG, F-38000 Grenoble (France); Desidera, Silvano [INAF—Osservatorio Astromonico di Padova, Vicolo dell’Osservatorio 5, I-35122 Padova (Italy)

    2016-01-01

    The Search for Planets Orbiting Two Stars survey aims to study the formation and distribution of planets in binary systems by detecting and characterizing circumbinary planets and their formation environments through direct imaging. With the SPHERE Extreme Adaptive Optics instrument, a good contrast can be achieved even at small (<300 mas) separations from bright stars, which enables studies of planets and disks in a separation range that was previously inaccessible. Here, we report the discovery of resolved scattered light emission from the circumbinary disk around the well-studied young double star AK Sco, at projected separations in the ∼13–40 AU range. The sharp morphology of the imaged feature is surprising, given the smooth appearance of the disk in its spectral energy distribution. We show that the observed morphology can be represented either as a highly eccentric ring around AK Sco, or as two separate spiral arms in the disk, wound in opposite directions. The relative merits of these interpretations are discussed, as well as whether these features may have been caused by one or several circumbinary planets interacting with the disk.

  8. Evidence for circumstellar obscuration of OB stars

    International Nuclear Information System (INIS)

    Bohannan, B.

    1975-01-01

    Reddish found a strong increase of color excess with increasing stellar luminosity: here referred to as the Reddish Effect: in ten young galactic clusters and associations. New photometric and spectroscopic observations drawn from the literature are combined with data used by Reddish to reconsider the color excess versus intrinsic magnitude diagrams of the same ten stellar groups. The reality of the Effect is questioned in all but one of the systems; this was accomplished by identifying possible foreground stars and by recognizing some of the brightest stars as supergiants, then applying correct intrinsic color indices. After careful reanalysis, the one stellar group to retain an indication of the Reddish Effect is Cygnus OB2. No correlation of reddening with luminosity was found for five additional very young stellar groups in the southern hemisphere; these groups should exhibit the Effect if it is a natural consequence of stellar evolution. Reddish ascribed the correlation to massive circumstellar remnants of material from which the stars formed. However, a peculiar dispersion in color excess could also be attributed to patchy dust within the stellar group. In several stellar systems previously identified as displaying the Reddish Effect, a correlation of observed color excess with dust and gas concentrations is noted on Palomar Sky Survey prints. If present, circumstellar dust clouds should []anifest their existence in modes other than a correlation of color excess with luminosity. The following possibilities are considered and all show negative results: correlation of color excess with spectral type; correlation of reddening slope E/subU//sub -//subB//E/subB//sub -//subV/ with spectral type; observable infrared excess. The preceding astrophysical arguments strongly imply that circumstellar dust remnants from stellar formation do not remain around stars during their main-sequence lifetimes. (auth)

  9. Analisis Balance of Interest pada Aliansi Tiongkok dan Rusia dalam Shanghai Cooperation Organisation (SCO Periode 2001-2007

    Directory of Open Access Journals (Sweden)

    Candini Candanila

    2014-12-01

    Full Text Available Interaksi Cina dan Rusia di kawasan Asia Tengah, khususnya dalam kerangka kerjasama Shanghai Cooperation Organisation (SCO, merupakan fenomena yang menarik untuk dikaji mengingat kedua negara tersebut tergolong sebagai great power, memiliki kepentingan yang hampir serupa di bidang energi dalam kawasan tersebut, namun memiliki political goals yang cukup berbeda. Tulisan ini mencoba mengkaji secara mendalam tentang bagaimana kesetimbangan kepentingan (balance of interest dari Cina dan Rusia di bidang energi beserta besarnya kapabilitas nasional dari kedua negara tersebut menjadi faktor penentu dalam pembentukan SCO bersama Kazakstan, Kirgistan, Tajikistan, dan Uzbekistan. Tulisan ini juga menunjukkan bagaimana political goals yang berbeda dapat dikesampingkan oleh negara-negara demi tercapainya kepentingan nasional mereka.

  10. Impaired transport of thyroid hormones into livers of obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Hillgartner, F.B.; Romsos, D.R.

    1988-01-01

    Obese (ob/ob) mice exhibit impaired hepatic thyroid hormone action that is mediated, at least in part, by a reduced nuclear 3,5,3'-triiodothyronine (T 3 ) receptor occupancy. The possibility that lowered occupancy in obese mice may be caused by decreased transport of T 3 across the hepatic plasma membrane was examined by measuring the unidirectional influx of [ 125 I]T 3 into livers of 8- to 10-wk-old obese and lean mice using a tissue-sampling portal vein-injection technique. Influx of [ 125 I]thyroxine (T 4 ), a substrate for T 4 5'-deiodinase, was also measured. Unidirectional clearance of T 3 and T 4 was 64 and 80% lower, respectively, in obese mice than in lean mice. Hepatic T 3 and T 4 uptake was nonsaturable in both lean and obese mice, suggesting that transport occurs by lipid-mediated free diffusion. Clearance of another lipid-soluble hormone, hydrocortisone, was also lower in obese mice than in lean mice. Decreased membrane permeability to the above hormones in obese mice may result from reported changes in membrane lipid composition. In conclusion, decreased hepatic thyroid hormone uptake may contribute to impaired thyroid hormone action and T 3 production in livers of obese mice

  11. Nuclear triiodothyronine receptor binding characteristics and occupancy in obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Hillgartner, F.B.; Romsos, D.R.

    1987-01-01

    Obese (ob/ob) mice exhibit reduced adaptive thermogenesis associated with an impairment of thyroid hormone action. The mechanism underlying the latter defect was investigated by comparing the binding characteristics and occupancy of solubilized nuclear 3,5,3'-triiodothyronine (T 3 ) receptors from livers of lean and obese mice. T 3 concentration was measured by radioimmunoassay. Scatchard analysis showed minimal differences in B/sub max/ and K/sub d/ between phenotypes at both 4 and 8-10 wk of age, indicating that reduced hepatic thyroid hormone expression in obese mice is not caused by alterations in nuclear receptor concentration or affinity. In contrast, nuclear T 3 receptor occupancy (endogenous T 3 associated with the specific receptor divided by B/sub max/) was 14 and 23% lower in 4- and 8- to 10-wk old obese mice, respectively. Together with reported changes in hepatic thyroid hormone-sensitive enzymes, these data are consistent with a diminished nuclear T 3 signal initiating thyroid hormone action in obese mice. Decreased nuclear T 3 receptor occupancy may be secondary to a low transport of plasma T 3 to the nuclear pool. In conclusion, impaired hepatic thyroid hormone action in obese mice is mediated in part at least by a reduction in nuclear T 3 receptor occupancy

  12. Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.

    Science.gov (United States)

    Chen, H-L; Tung, Y-T; Tsai, C-L; Lai, C-W; Lai, Z-L; Tsai, H-C; Lin, Y-L; Wang, C-H; Chen, C-M

    2014-09-01

    Fatty liver disease is commonly associated with obesity, insulin resistance and diabetes. Severe fatty liver is sometimes accompanied by steatohepatitis and may lead to the development of hepatocellular carcinoma. At present, there is no effective treatment for non-alcoholic fatty liver disease (NAFLD); thus, recent investigations have focused on developing effective therapeutics to treat this condition. This study aimed to evaluate the effects of kefir on the hepatic lipid metabolism of ob/ob mice, which are commonly used to model fatty liver disease. In this study, we used leptin receptor-deficient ob/ob mice as an animal disease model of NAFLD. Six-week-old ob/ob mice were orally administered the dairy product kefir (140 mg kg(-1) of body weight (BW) per day) for 4 weeks. The data demonstrated that kefir improved fatty liver syndrome on BW, energy expenditure and basal metabolic rate by inhibiting serum glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) activities (Pkefir administration also significantly reduced the macrovesicular fat quantity in liver tissue. In addition, kefir markedly decreased the expression of the genes sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) (Pkefir improves NAFLD on BW, energy expenditure and basal metabolic rate by inhibiting the lipogenesis pathway and that kefir may have the potential for clinical application to the prevention or treatment of NAFLD.

  13. Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lepob/ob mice

    International Nuclear Information System (INIS)

    Sekiya, Motohiro; Yahagi, Naoya; Tamura, Yoshiaki; Okazaki, Hiroaki; Igarashi, Masaki; Ohta, Keisuke; Takanashi, Mikio; Kumagai, Masayoshi; Takase, Satoru; Nishi, Makiko; Takeuchi, Yoshinori; Izumida, Yoshihiko; Kubota, Midori; Ohashi, Ken; Iizuka, Yoko; Yagyu, Hiroaki; Gotoda, Takanari; Nagai, Ryozo; Shimano, Hitoshi; Yamada, Nobuhiro

    2009-01-01

    It has long been a matter of debate whether the hormone-sensitive lipase (HSL)-mediated lipolysis in pancreatic β-cells can affect insulin secretion through the alteration of lipotoxicity. We generated mice lacking both leptin and HSL (Lep ob/ob /HSL -/- ) and explored the role of HSL in pancreatic β-cells in the setting of obesity. Lep ob/ob /HSL -/- developed elevated blood glucose levels and reduced plasma insulin levels compared with Lep ob/ob /HSL +/+ in a fed state, while the deficiency of HSL did not affect glucose homeostasis in Lep +/+ background. The deficiency of HSL exacerbated the accumulation of triglycerides in Lep ob/ob islets, leading to reduced glucose-stimulated insulin secretion. The deficiency of HSL also diminished the islet mass in Lep ob/ob mice due to decreased cell proliferation. In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity.

  14. Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High Fat Diets

    Directory of Open Access Journals (Sweden)

    Laurence B Lindenmaier

    2016-08-01

    Full Text Available Low bone mass is often associated with increased bone marrow adiposity. Since osteoblasts and adipocytes are derived from the same mesenchymal stem cell progenitor, adipocyte formation may increase at the expense of osteoblast formation. Leptin is an adipocyte-derived hormone known to regulate energy and bone metabolism. Genetic (e.g., leptin deficiency and high fat diet-induced (e.g., leptin resistance obesity are associated with increased marrow adipose tissue (MAT and reduced bone formation. Short-duration studies suggest that leptin treatment reduces MAT and increases bone formation in leptin-deficient ob/ob mice fed a regular diet. Here, we determined the long-duration impact of increased hypothalamic leptin on marrow adipocytes and osteoblasts in ob/ob mice using recombinant adeno-associated virus (rAAV gene therapy. In a first study, eight- to ten-week-old male ob/ob mice were randomized into 4 groups: (1 untreated, (2 rAAV-Lep, (3 rAAV-green fluorescent protein (rAAV-GFP, or (4 pair-fed to rAAV-Lep. For vector administration, mice were placed in a Kopf stereotaxic apparatus, and injected intracerebroventricularly with either rAAV-Lep or rAAV-GFP (9 × 107 particles in 1.5 µl. The mice were maintained for 30 weeks following vector administration. In a second study, the impact of increased hypothalamic leptin levels on MAT was determined in mice fed high fat diets. Eight- to ten-week-old male ob/ob mice were randomized into 2 groups and treated with either rAAV-Lep or rAAV-GFP. At 7 weeks post-vector administration, half the mice in each group were switched to a high fat diet for 8 weeks. Wild type (WT controls included age-matched mice fed regular or high fat diet. Hypothalamic leptin gene therapy increased osteoblast perimeter and osteoclast perimeter with minor change in cancellous bone architecture. The gene therapy decreased MAT levels in ob/ob mice fed regular or high fat diet to values similar to WT mice fed regular diet. These

  15. LMTD Design Methodology Assessment of Spiral Tube Heat Exchanger under the S-CO2 cycle operating condition

    International Nuclear Information System (INIS)

    Jung, Hwa Young; Lee, Jeong Ik; Ahn, Yoon Han

    2013-01-01

    The advantages of PCHE are compact high pressure difference endurance high temperature operation. However, PCHE is quite expensive and the resistance to the fast thermal cycling is questionable. In order to overcome this problem, the Korea Advanced Institute of Science and Technology (KAIST) research team is considering an alternative for the PCHE. Currently KAIST research team is using a Spiral Tube Heat Exchanger (STHE) of Sentry Equipment Corp. as a pre cooler in the SCO 2 PE facility. A STHE is relatively cheap but the operating pressure and temperature are acceptable for utilizing it as a pre cooler. A STHE is consisted of spiral shaped tubes (hot side i.e. S-CO 2 ) immersed in a shell (cold side i.e. water). This study is aimed at whether the logarithmic mean temperature difference (LMTD) heat exchanger design methodology is acceptable for designing the S-CO 2 cycle pre cooler. This is because the LMTD method usually assumes a constant specific heat, but the pre cooler in the S-CO 2 cycle operates at the nearest point to the critical point where a dramatic change in properties is expected. Experimentally obtained data are compared to the vendor provided technical specification based on the LMTD method. The detailed specifications provided by the vendor are listed in Table 1

  16. Early X-ray and radio observations of Nova Sco 2015 implicate strong shocks against a red giant wind

    Science.gov (United States)

    Nelson, T.; Linford, J.; Chomiuk, L.; Sokoloski, J.; Mukai, K.; Finzell, T.; Weston, J.; Rupen, M.; Mioduszewski, A.

    2015-02-01

    We report the first observations of Nova Sco 2015 (PNV J17032620-3504140) at X-ray, UV and radio wavelengths. The X-ray observations were carried out with the Swift satellite between 2015 February 15.5 and 16.3 UT (roughly 4 days after discovery) and resulted in a total exposure time with the XRT instrument of 4065 s.

  17. Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA.

    Directory of Open Access Journals (Sweden)

    Guang Liu

    2010-12-01

    Full Text Available Many taxonomically diverse prokaryotes enzymatically modify their DNA by replacing a non-bridging oxygen with a sulfur atom at specific sequences. The biological implications of this DNA S-modification (phosphorothioation were unknown. We observed that simultaneous expression of the dndA-E gene cluster from Streptomyces lividans 66, which is responsible for the DNA S-modification, and the putative Streptomyces coelicolor A(32 Type IV methyl-dependent restriction endonuclease ScoA3McrA (Sco4631 leads to cell death in the same host. A His-tagged derivative of ScoA3McrA cleaved S-modified DNA and also Dcm-methylated DNA in vitro near the respective modification sites. Double-strand cleavage occurred 16-28 nucleotides away from the phosphorothioate links. DNase I footprinting demonstrated binding of ScoA3McrA to the Dcm methylation site, but no clear binding could be detected at the S-modified site under cleavage conditions. This is the first report of in vitro endonuclease activity of a McrA homologue and also the first demonstration of an enzyme that specifically cleaves S-modified DNA.

  18. Solution structure of the major fish allergen parvalbumin Sco j 1 derived from the Pacific mackerel.

    Science.gov (United States)

    Kumeta, Hiroyuki; Nakayama, Haruka; Ogura, Kenji

    2017-12-07

    Although fish is an important part of the human diet, it is also a common source of food allergy. The major allergen in fish is parvalbumin, a well-conserved Ca 2+ -binding protein found in the white muscle of many fish species. Here, we studied the solution structure of the parvalbumin Sco j 1, derived from the Pacific mackerel, using nuclear magnetic resonance spectroscopy. We mapped the IgE-binding epitope proposed in a recent study onto the present structure. Interestingly, three of four residues, which were elucidated as key residues of the IgE-binding epitope, were exposed to solvent, whereas one residue faced the inside of the molecule. We expect that this solution structure can be used in future studies attempting to analyze the various IgE-binding modes of these allergens.

  19. A MULTIPHASE SUZAKU STUDY OF X-RAYS FROM τ Sco

    International Nuclear Information System (INIS)

    Ignace, R.; Oskinova, L. M.; Jardine, M.; Cassinelli, J. P.; Townsend, R. H. D.; Cohen, D. H.; Donati, J.-F.; Ud-Doula, A.

    2010-01-01

    We obtained relatively high signal-to-noise X-ray spectral data of the early massive star τ Sco (B0.2V) with the Suzaku X-ray Imaging Spectrometer (XIS) instrument. This source displays several unusual features that motivated our study: (1) redshifted absorption in UV P Cygni lines to approximately +250 km s -1 suggestive of infalling gas, (2) unusually hard X-ray emission requiring hot plasma at temperatures in excess of 10 MK whereas most massive stars show relatively soft X-rays at a few MK, and (3) a complex photospheric magnetic field of open and closed field lines. In an attempt to understand the hard component better, X-ray data were obtained at six roughly equally spaced phases within the same epoch of τ Sco's 41 day rotation period. The XIS instrument has three operable detectors: XIS1 is back-illuminated with sensitivity down to 0.2 keV; XIS0 and XIS2 are front-illuminated with sensitivity only down to 0.4 keV and have an overall less effective area than XIS1. The XIS0 and XIS3 detectors show relatively little variability. In contrast, there is a ∼4σ detection of a ∼4% drop in the count rate of the XIS1 detector at one rotational phase. In addition, all three detectors show a ∼3% increase in count rate at the same phase. The most optimistic prediction of X-ray variability allows for a 40% change in the count rate, particularly near phases where we have pointings. Observed modulations in the X-ray light curve on the rotation cycle is an order of magnitude smaller than this, which places new stringent constraints on future modeling of this interesting magnetic massive star.

  20. Interaction between SCO-spondin and low density lipoproteins from embryonic cerebrospinal fluid modulates their roles in early neurogenesis

    Directory of Open Access Journals (Sweden)

    América eVera

    2015-05-01

    Full Text Available During early stages of development, encephalic vesicles are composed by a layer of neuroepithelial cells surrounding a central cavity filled with embryonic cerebrospinal fluid (eCSF. This fluid contains several morphogens that regulate proliferation and differentiation of neuroepithelial cells. One of these neurogenic factors is SCO-spondin, a giant protein secreted to the eCSF from early stages of development. Inhibition of this protein in vivo or in vitro drastically decreases the neurodifferentiation process. Other important neurogenic factors of the eCSF are low density lipoproteins (LDL, the depletion of which generates a 60% decrease in mesencephalic explant neurodifferentiation. The presence of several LDL receptor class A (LDLrA domains (responsible for LDL binding in other proteins in the SCO-spondin sequence suggests a possible interaction between both molecules. This possibility was analyzed using three different experimental approaches: 1 Bioinformatics analyses of the SCO-spondin region, that contains eight LDLrA domains in tandem, and of comparisons with the LDL receptor consensus sequence; 2 Analysis of the physical interactions of both molecules through immunohistochemical colocalization in embryonic chick brains and through the immunoprecipitation of LDL with anti-SCO-spondin antibodies; and 3 Analysis of functional interactions during the neurodifferentiation process when these molecules were added to a culture medium of mesencephalic explants. The results revealed that LDL and SCO-spondin interact to form a complex that diminishes the neurogenic capacities that both molecules have separately. Our work suggests that the embryonic cerebrospinal fluid is an active signaling center with a complex regulation system that allows for correct brain development.

  1. Investigation and Analysis of Genetic Diversity of Diospyros Germplasms Using SCoT Molecular Markers in Guangxi.

    Science.gov (United States)

    Deng, Libao; Liang, Qingzhi; He, Xinhua; Luo, Cong; Chen, Hu; Qin, Zhenshi

    2015-01-01

    Knowledge about genetic diversity and relationships among germplasms could be an invaluable aid in diospyros improvement strategies. This study was designed to analyze the genetic diversity and relationship of local and natural varieties in Guangxi Zhuang Autonomous Region of China using start codon targeted polymorphism (SCoT) markers. The accessions of 95 diospyros germplasms belonging to four species Diospyros kaki Thunb, D. oleifera Cheng, D. kaki var. silverstris Mak, and D. lotus Linn were collected from different eco-climatic zones in Guangxi and were analyzed using SCoT markers. Results indicated that the accessions of 95 diospyros germplasms could be distinguished using SCoT markers, and were divided into three groups at similarity coefficient of 0.608; these germplasms that belong to the same species were clustered together; of these, the degree of genetic diversity of the natural D. kaki var. silverstris Mak population was richest among the four species; the geographical distance showed that the 12 natural populations of D. kaki var. silverstris Mak were divided into two groups at similarity coefficient of 0.19. Meanwhile, in order to further verify the stable and useful of SCoT markers in diospyros germplasms, SSR markers were also used in current research to analyze the genetic diversity and relationship in the same diospyros germplasms. Once again, majority of germplasms that belong to the same species were clustered together. Thus SCoT markers were stable and especially useful for analysis of the genetic diversity and relationship in diospyros germplasms. The molecular characterization and diversity assessment of diospyros were very important for conservation of diospyros germplasm resources, meanwhile for diospyros improvement.

  2. The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis

    Directory of Open Access Journals (Sweden)

    Christopher J. Hlynialuk

    2015-02-01

    Full Text Available Human SCO1 fulfills essential roles in cytochrome c oxidase (COX assembly and the regulation of copper (Cu homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here, we establish a Sco1 mouse model of human disease and show that ablation of Sco1 expression in the liver is lethal owing to severe COX and Cu deficiencies. We further demonstrate that the Cu deficiency is explained by a functional connection between SCO1 and CTR1, the high-affinity transporter that imports Cu into the cell. CTR1 is rapidly degraded in the absence of SCO1 protein, and we show that its levels are restored in Sco1−/− mouse embryonic fibroblasts upon inhibition of the proteasome. These data suggest that mitochondrial signaling through SCO1 provides a post-translational mechanism to regulate CTR1-dependent Cu import into the cell, and they further underpin the importance of mitochondria in cellular Cu homeostasis.

  3. Obs4MIPS: Satellite Observations for Model Evaluation

    Science.gov (United States)

    Ferraro, R.; Waliser, D. E.; Gleckler, P. J.

    2017-12-01

    This poster will review the current status of the obs4MIPs project, whose purpose is to provide a limited collection of well-established and documented datasets for comparison with Earth system models (https://www.earthsystemcog.org/projects/obs4mips/). These datasets have been reformatted to correspond with the CMIP5 model output requirements, and include technical documentation specifically targeted for their use in model output evaluation. The project holdings now exceed 120 datasets with observations that directly correspond to CMIP5 model output variables, with new additions in response to the CMIP6 experiments. With the growth in climate model output data volume, it is increasing more difficult to bring the model output and the observations together to do evaluations. The positioning of the obs4MIPs datasets within the Earth System Grid Federation (ESGF) allows for the use of currently available and planned online tools within the ESGF to perform analysis using model output and observational datasets without necessarily downloading everything to a local workstation. This past year, obs4MIPs has updated its submission guidelines to closely align with changes in the CMIP6 experiments, and is implementing additional indicators and ancillary data to allow users to more easily determine the efficacy of an obs4MIPs dataset for specific evaluation purposes. This poster will present the new guidelines and indicators, and update the list of current obs4MIPs holdings and their connection to the ESGF evaluation and analysis tools currently available, and being developed for the CMIP6 experiments.

  4. Mining the Obscured OB Star Population in Carina

    Science.gov (United States)

    Smith, Michael

    2016-04-01

    Massive OB stars are very influential objects in the ecology of galaxies like our own. Current catalogues of Galactic OB stars are heavily biased towards bright (g selected OB stars across the entire Southern Galactic plane, both within clusters and in the field, down to ∼20th magnitude in g. For the first time, a complete accounting of the OB star runaway phenomenon becomes possible. Along with making the primary selection using VPHAS+ colours, I have performed Markov-Chain Monte Carlo fitting of the spectral energy distributions of the selected stars by combining VPHAS+ u, g, r, i with published J, H, K photometry. This gives rough constraints on effective temperature and distance, whilst delivering much more precise reddening parameters A0 and RV - allowing us to build a much richer picture of how extinction and extinction laws vary across the Galactic Plane. My thesis begins with a description of the method of photometric selection of OB star candidates and its validation across a 2 square degree field including the well-known young massive star cluster Westerlund 2 (Mohr-Smith et al., 2015). Following on from this I present spectroscopy with AAOmega of 283 candidates identified by our method, which confirms that ∼94% of the sample are the expected O and early B stars. I then develop this method further and apply it to a Galactic Plane strip of 42 square-degrees that runs from the Carina Arm tangent region to the much studied massive cluster in NGC 3603. A new aspect I attend to in this expansion of method is tightening up the uniform photometric calibration of the data, paying particular attention to the always-challenging u band. This leads to a new and reliable catalogue of 5915 OB stars. As well as increasing the numbers of identified massive stars in this large region of the sky by nearly an order of magnitude, a more complete picture of massive star formation in the Carina Arm has emerged. I have found a broad over-density of O stars around the highly

  5. Hard X-ray Flux from Low-Mass Stars in the Cygnus OB2 Association

    Science.gov (United States)

    Caramazza, M.; Drake, J. J.; Micela, G.; Flaccomio, E.

    2009-05-01

    We investigate the X-ray emission in the 20-40 keV band expected from the flaring low-mass stellar population in Cygnus OB2 assuming that the observed soft X-ray emission is due to a superposition of flares and that the ratio of hard X-ray to soft X-ray emission is described by a scaling found for solar flares by Isola and co-workers. We estimate a low-mass stellar hard X-ray flux in the 20-40 keV band in the range ~7×1031-7×1033 erg/s and speculate the limit of this values. Hard X-ray emission could lie at a level not much below the current observed flux upper limits for Cygnus OB2. Simbol-X, with its broad energy band (10-100 keV) and its sensitivity should be able to detect this emission and would provide insights into the hard X-ray production of flares on pre-main sequence stars.

  6. Expression of Leptin (Ob Gene Product) in Reproductive System ...

    African Journals Online (AJOL)

    Purpose: To determine serum leptin and its ob mRNA expression both in the PCOS and non-PCOS ovary, endometrium and adipose tissue in normal or polycystic ovary syndrome (PCOS) in South Indian population. PCOS (Polycystic Ovary Syndrome) and non-PCOS subject's endometrium, ovary and adipose tissue were ...

  7. SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex.

    Science.gov (United States)

    Madan, Esha; Gogna, Rajan; Kuppusamy, Periannan; Bhatt, Madan; Mahdi, Abbas Ali; Pati, Uttam

    2013-04-01

    p53 prevents cancer via cell cycle arrest, apoptosis, and the maintenance of genome stability. p53 also regulates energy-generating metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis via transcriptional regulation of SCO2 and TIGAR. SCO2, a cytochrome c oxidase assembly factor, is a metallochaperone which is involved in the biogenesis of cytochrome c oxidase subunit II. Here we have shown that SCO2 functions as an apoptotic protein in tumor xenografts, thus providing an alternative pathway for p53-mediated apoptosis. SCO2 increases the generation of reactive oxygen species (ROS) and induces dissociation of the protein complex between apoptosis signal-regulating kinase 1 (ASK-1) (mitogen-activated protein kinase kinase kinase [MAPKKK]) and its cellular inhibitor, the redox-active protein thioredoxin (Trx). Furthermore, SCO2 induces phosphorylation of ASK-1 at the Thr(845) residue, resulting in the activation of the ASK-1 kinase pathway. The phosphorylation of ASK-1 induces the activation of mitogen-activated protein kinase kinases 4 and 7 (MAP2K4/7) and MAP2K3/6, which switches the c-Jun N-terminal protein kinase (JNK)/p38-dependent apoptotic cascades in cancer cells. Exogenous addition of the SCO2 gene to hypoxic cancer cells and hypoxic tumors induces apoptosis and causes significant regression of tumor xenografts. We have thus discovered a novel apoptotic function of SCO2, which activates the ASK-1 kinase pathway in switching "on" an alternate mode of p53-mediated apoptosis. We propose that SCO2 might possess a novel tumor suppressor function via the ROS-ASK-1 kinase pathway and thus could be an important candidate for anticancer gene therapy.

  8. Start Codon Targeted (SCoT) marker reveals genetic diversity of Dendrobium nobile Lindl., an endangered medicinal orchid species.

    Science.gov (United States)

    Bhattacharyya, Paromik; Kumaria, Suman; Kumar, Shrawan; Tandon, Pramod

    2013-10-15

    Genetic variability in the wild genotypes of Dendrobium nobile Lindl. collected from different parts of Northeast India, was analyzed using a Start Codon Targeted (SCoT) marker system. A total of sixty individuals comprising of six natural populations were investigated for the existing natural genetic diversity. One hundred and thirty two (132) amplicons were produced by SCoT marker generating 96.21% polymorphism. The PIC value of the SCoT marker system was 0.78 and the Rp values of the primers ranged between 4.43 and 7.50. The percentage of polymorphic loci (Pp) ranging from 25% to 56.82%, Nei's gene diversity (h) from 0.08 to 0.15 with mean Nei's gene diversity of 0.28, and Shannon's information index (I) values ranging from 0.13 to 0.24 with an average value of 0.43 were recorded. The gene flow value (0.37) and the diversity among populations (0.57) demonstrated higher genetic variation among the populations. Analysis of molecular variance (AMOVA) showed 43.37% of variation within the populations, whereas 56.63% variation was recorded among the populations. Cluster analysis also reveals high genetic variation among the genotypes. Present investigation suggests the effectiveness of SCoT marker system to estimate the genetic diversity of D. nobile and that it can be seen as a preliminary point for future research on the population and evolutionary genetics of this endangered orchid species of medicinal importance. © 2013.

  9. Triggering risk factors of the burnout syndrome in OB/GYN physicians from a reference public university of Brazil.

    Science.gov (United States)

    Ferreira Bortoletti, Fátima; Teresa Benevides-Pereira, Ana Maria; Vasconcellos, Esdras Guerreiro; Siqueira, José Oliveira; Araujo Júnior, Edward; Nardozza, Luciano Marcondes Machado; Sebastiani, Ricardo Werner; Moron, Antonio Fernandes

    2012-01-01

    Objective. To identify the risk factors to the development of Burnout Syndrome in Ob/Gyn Brazilian physicians in four dimensions: emotional exhaustion (EE), professional repression (PR), dehumanization (De), and emotional distancing (EmD). Methods. A prospective cross-sectional study was realized with 48 Ob/Gyn physicians (12 lecturers, 12 attending physicians, 12 medical residents, and 12 graduate students) from Department of Obstetrics, São Paulo Federal University (UNIFESP). We used a sociodemographic questionnaire focusing on the activities (administrative, educational, healthcare, and research). We applied a Burnout Syndrome Inventory (BSI) composed of two parts: triggering factors (ISB1) and the Burnout Syndrome (ISB2). The ISB1 is composed of two scales: positive organizational conditions (POC) and negative organizational conditions (NOC). The ISB2 is composed of four scales: EE, PR, De, and EmD. Results. We observed a rate below and above average to POC and NOC, respectively. The dimensions recorded a level above average to EE, an index at the upper limit of the average to De, a median index to EmD, and a median index to PR. Conclusions. The Ob/Gyn physicians are in an area of vulnerability for the development of Burnout Syndrome due to the high level of EE and De, associated with a median index of PR. The high rate of NOC contributes to the triggering of this scenery.

  10. Potential of Start Codon Targeted (SCoT Markers to Estimate Genetic Diversity and Relationships among Chinese Elymus sibiricus Accessions

    Directory of Open Access Journals (Sweden)

    Junchao Zhang

    2015-04-01

    Full Text Available Elymus sibiricus as an important forage grass and gene pool for improving cereal crops, that is widely distributed in West and North China. Information on its genetic diversity and relationships is limited but necessary for germplasm collection, conservation and future breeding. Start Codon Targeted (SCoT markers were used for studying the genetic diversity and relationships among 53 E. sibiricus accessions from its primary distribution area in China. A total of 173 bands were generated from 16 SCoT primers, 159 bands of which were polymorphic with the percentage of polymorphic bands (PPB of 91.91%. Based upon population structure analysis five groups were formed. The cluster analysis separated the accessions into two major clusters and three sub-clusters, similar to results of principal coordinate analysis (PCoA. The molecular variance analysis (AMOVA showed that genetic variation was greater within geographical regions (50.99% than between them (49.01%. Furthermore, the study also suggested that collecting and evaluating E. sibiricus germplasm for major geographic regions and special environments broadens the available genetic base and illustrates the range of variation. The results of the present study showed that SCoT markers were efficient in assessing the genetic diversity among E. sibiricus accessions.

  11. Genetic variation, population structure and linkage disequilibrium in Switchgrass with ISSR, SCoT and EST-SSR markers.

    Science.gov (United States)

    Zhang, Yu; Yan, Haidong; Jiang, Xiaomei; Wang, Xiaoli; Huang, Linkai; Xu, Bin; Zhang, Xinquan; Zhang, Lexin

    2016-01-01

    To evaluate genetic variation, population structure, and the extent of linkage disequilibrium (LD), 134 switchgrass ( Panicum virgatum L.) samples were analyzed with 51 markers, including 16 ISSRs, 20 SCoTs, and 15 EST-SSRs. In this study, a high level of genetic variation was observed in the switchgrass samples and they had an average Nei's gene diversity index (H) of 0.311. A total of 793 bands were obtained, of which 708 (89.28 %) were polymorphic. Using a parameter marker index (MI), the efficiency of the three types of markers (ISSR, SCoT, and EST-SSR) in the study were compared and we found that SCoT had a higher marker efficiency than the other two markers. The 134 switchgrass samples could be divided into two sub-populations based on STRUCTURE, UPGMA clustering, and principal coordinate analyses (PCA), and upland and lowland ecotypes could be separated by UPGMA clustering and PCA analyses. Linkage disequilibrium analysis revealed an average r 2 of 0.035 across all 51 markers, indicating a trend of higher LD in sub-population 2 than that in sub-population 1 ( P  < 0.01). The population structure revealed in this study will guide the design of future association studies using these switchgrass samples.

  12. iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling.

    Science.gov (United States)

    Deng, Xiuling; Wang, Jiliang; Jiao, Li; Utaipan, Tanyarath; Tuma-Kellner, Sabine; Schmitz, Gerd; Liebisch, Gerhard; Stremmel, Wolfgang; Chamulitrat, Walee

    2016-05-01

    PLA2G6 or GVIA calcium-independent PLA2 (iPLA2β) is identified as one of the NAFLD modifier genes in humans, and thought to be a target for NAFLD therapy. iPLA2β is known to play a house-keeping role in phospholipid metabolism and remodeling. However, its role in NAFLD pathogenesis has not been supported by results obtained from high-fat feeding of iPLA2β-null (PKO) mice. Unlike livers of human NAFLD and genetically obese rodents, fatty liver induced by high-fat diet is not associated with depletion of hepatic phospholipids. We therefore tested whether iPLA2β could regulate obesity and hepatic steatosis in leptin-deficient mice by cross-breeding PKO with ob/ob mice to generate ob/ob-PKO mice. Here we observed an improvement in ob/ob-PKO mice with significant reduction in serum enzymes, lipids, glucose, insulin as well as improved glucose tolerance, and reduction in islet hyperplasia. The improvement in hepatic steatosis measured by liver triglycerides, fatty acids and cholesterol esters was associated with decreased expression of PPARγ and de novo lipogenesis genes, and the reversal of β-oxidation gene expression. Notably, ob/ob livers contained depleted levels of lysophospholipids and phospholipids, and iPLA2β deficiency in ob/ob-PKO livers lowers the former, but replenished the latter particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC) that contained arachidonic (AA) and docosahexaenoic (DHA) acids. Compared with WT livers, PKO livers also contained increased PE and PC containing AA and DHA. Thus, iPLA2β deficiency protected against obesity and ob/ob fatty liver which was associated with hepatic fatty-acyl phospholipid remodeling. Our results support the deleterious role of iPLA2β in severe obesity associated NAFLD. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. Leptin Reduces the Expression and Increases the Phosphorylation of the Negative Regulators of GLUT4 Traffic TBC1D1 and TBC1D4 in Muscle of ob/ob Mice

    Science.gov (United States)

    Sáinz, Neira; Rodríguez, Amaia; Catalán, Victoria; Becerril, Sara; Ramírez, Beatriz; Lancha, Andoni; Burgos-Ramos, Emma; Gómez-Ambrosi, Javier; Frühbeck, Gema

    2012-01-01

    Leptin improves insulin sensitivity in skeletal muscle. Our goal was to determine whether proteins controlling GLUT4 traffic are altered by leptin deficiency and in vivo leptin administration in skeletal muscle of wild type and ob/ob mice. Leptin-deficient ob/ob mice were divided in three groups: control, leptin-treated (1 mg/kg/d) and leptin pair-fed ob/ob mice. Microarray analysis revealed that 1,546 and 1,127 genes were regulated by leptin deficiency and leptin treatment, respectively. Among these, we identified 24 genes involved in intracellular vesicle-mediated transport in ob/ob mice. TBC1 domain family, member 1 (Tbc1d1), a negative regulator of GLUT4 translocation, was up-regulated (P = 0.001) in ob/ob mice as compared to wild types. Importantly, leptin treatment reduced the transcript levels of Tbc1d1 (P<0.001) and Tbc1d4 (P = 0.004) in the leptin-treated ob/ob as compared to pair-fed ob/ob animals. In addition, phosphorylation levels of TBC1D1 and TBC1D4 were enhanced in leptin-treated ob/ob as compared to control ob/ob (P = 0.015 and P = 0.023, respectively) and pair-fed ob/ob (P = 0.036 and P = 0.034, respectively) mice. Despite similar GLUT4 protein expression in wild type and ob/ob groups a different immunolocalization of this protein was evidenced in muscle sections. Leptin treatment increased GLUT4 immunoreactivity in gastrocnemius and extensor digitorum longus sections of leptin-treated ob/ob mice. Moreover, GLUT4 protein detected in immunoprecipitates from TBC1D4 was reduced by leptin replacement compared to control ob/ob (P = 0.013) and pair-fed ob/ob (P = 0.037) mice. Our findings suggest that leptin enhances the intracellular GLUT4 transport in skeletal muscle of ob/ob animals by reducing the expression and activity of the negative regulators of GLUT4 traffic TBC1D1 and TBC1D4. PMID:22253718

  14. Radio observations of the CMa OB1 H II regions

    International Nuclear Information System (INIS)

    Gaylard, M.J.; Kemball, A.J.

    1984-01-01

    A sensitive 10 0 x 15 0 13-cm map made of the CMa OB1 H II regions' radio emission shows a strong similarity to Hα emission photographs. Sharpless 296 is shown to consist of a prominent central and western arc completed by a weaker southern loop, and with a faint northern bar. The emission is thermal, superimposed over a predominantly non-thermal background. The H142α recombination line has been detected at eight positions in S296, and in S292 and S297. The average electron temperature in S296 is 6900 +- 1300 K. The UV fluxes from the CMa OB1 stars account for the observed emission measures of the H II regions. The H142α 1sr velocities indicate that the ionized material is in contact with the molecular clouds. (author)

  15. Neutral hydrogen in the stellar accociation Scorpius OB-2

    Energy Technology Data Exchange (ETDEWEB)

    Bystrova, N.V.

    1979-01-01

    The distribution of neutral hydrogen connected with the stellar association Scorpius OB-2 is more complex than the expanding semienvelope suggested earlier. The neutral gas is in connection with the nebulae S1, S7, S9 and with H/sub ..cap alpha../-filaments found in the association and giving it the appearence of a spiral galaxy. The HI-distribution is in disagreement with the model of a supernova remnant.

  16. ObsPy: A Python Toolbox for Seismology

    Science.gov (United States)

    Krischer, Lion; Megies, Tobias; Sales de Andrade, Elliott; Barsch, Robert; MacCarthy, Jonathan

    2017-04-01

    In recent years the Python ecosystem evolved into one of the most powerful and productive scientific environments across disciplines. ObsPy (https://www.obspy.org) is a fully community-driven, open-source project dedicated to providing a bridge for seismology into that ecosystem. It does so by offering Read and write support for essentially every commonly used data format in seismology with a unified interface and automatic format detection. This includes waveform data (MiniSEED, SAC, SEG-Y, Reftek, …) as well as station (SEED, StationXML, …) and event meta information (QuakeML, ZMAP, …). Integrated access to the largest data centers, web services, and real-time data streams (FDSNWS, ArcLink, SeedLink, ...). A powerful signal processing toolbox tuned to the specific needs of seismologists. Utility functionality like travel time calculations with the TauP method, geodetic functions, and data visualizations. ObsPy has been in constant development for more than seven years and is developed and used by scientists around the world with successful applications in all branches of seismology. Additionally it nowadays serves as the foundation for a large number of more specialized packages. This presentation will give a short overview of the capabilities of ObsPy and point out several representative or new use cases. Additionally we will discuss the road ahead as well as the long-term sustainability of open-source scientific software.

  17. OBS Technologies and permanent seismic Stations at Sea

    Science.gov (United States)

    Makris, J.; Nikolova, S. B.

    2003-04-01

    An off-shore telemetric system was developed during last 2 years. It consists of a buoy unit, OBS with seismic sensor and digitizer at the sea floor and coaxial cable for transferring data from the sea. The buoy unit includes all components for recording and transmitting data to the base station. A solar panel and wind generator are the sources of energy that charge the batteries in the buoy. An Omni directional antenna and a radio modem are used for data transfer. The buoy can be connected also to mobile network or satellite. The Seismic recording unit is SEDIS IV developed in GeoPro GmbH which is a 6 channel data logger equipped with a hard disk of 30 GByte capacity and a flash memory of 0.5 Gbyte which can continuously record at different sampling rate (from 31.25 to 1000sps). The operating system for SEDIS IV is LINUX, with possible data compression, event location and extraction. The data transfer and supply of the power to seismometer and ADC unit in OBS sphere is done through coaxial cable, connecting the buoy unit and OBS. The whole system was tested for a period of one month (October 2002) within frame of Nestor program in Pilos (Greece) and worked successfully.

  18. ADDITIONAL MASSIVE BINARIES IN THE CYGNUS OB2 ASSOCIATION

    International Nuclear Information System (INIS)

    Kiminki, Daniel C.; Kobulnicky, Henry A.; Ewing, Ian; Lundquist, Michael; Alexander, Michael; Vargas-Alvarez, Carlos; Choi, Heather; Bagley Kiminki, Megan M.; Henderson, C. B.

    2012-01-01

    We report the discovery and orbital solutions for two new OB binaries in the Cygnus OB2 Association, MT311 (B2V + B3V) and MT605 (B0.5V + B2.5:V). We also identify the system MT429 as a probable triple system consisting of a tight eclipsing 2.97 day B3V+B6V pair and a B0V at a projected separation of 138 AU. We further provide the first spectroscopic orbital solutions to the eclipsing, double-lined, O-star binary MT696 (O9.5V + B1:V), the double-lined, early B binary MT720 (B0-1V + B1-2V), and the double-lined, O-star binary MT771 (O7V + O9V). These systems exhibit orbital periods between 1.5 days and 12.3 days, with the majority having P <6 days. The two new binary discoveries and six spectroscopic solutions bring the total number of known massive binaries in the central region of the Cygnus OB2 Association to 20, with all but two having full orbital solutions.

  19. ADDITIONAL MASSIVE BINARIES IN THE CYGNUS OB2 ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Kiminki, Daniel C.; Kobulnicky, Henry A.; Ewing, Ian; Lundquist, Michael; Alexander, Michael; Vargas-Alvarez, Carlos; Choi, Heather [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States); Bagley Kiminki, Megan M. [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States); Henderson, C. B. [Department of Astronomy, Ohio State University, Columbus, OH 43210 (United States)

    2012-03-01

    We report the discovery and orbital solutions for two new OB binaries in the Cygnus OB2 Association, MT311 (B2V + B3V) and MT605 (B0.5V + B2.5:V). We also identify the system MT429 as a probable triple system consisting of a tight eclipsing 2.97 day B3V+B6V pair and a B0V at a projected separation of 138 AU. We further provide the first spectroscopic orbital solutions to the eclipsing, double-lined, O-star binary MT696 (O9.5V + B1:V), the double-lined, early B binary MT720 (B0-1V + B1-2V), and the double-lined, O-star binary MT771 (O7V + O9V). These systems exhibit orbital periods between 1.5 days and 12.3 days, with the majority having P <6 days. The two new binary discoveries and six spectroscopic solutions bring the total number of known massive binaries in the central region of the Cygnus OB2 Association to 20, with all but two having full orbital solutions.

  20. Star formation in the Monoceros OB1 dark cloud

    International Nuclear Information System (INIS)

    Margulis, M.S.

    1987-01-01

    A survey of the Monoceros OB1 dark cloud was made for molecular outflows and young stellar objects. In all, nine molecular outflows and thirty far-infrared sources were identified in a portion of the cloud composed of about 3 x 10 4 M of material. Statistical arguments suggest that 90% of the far-infrared sources actually are young stellar objects embedded in the cloud. If the star formation rate in the Mon OB1 cloud is roughly constant with time, then molecular outflows in the cloud should be able to support it against collapse due to gravity. This suggests that the birthrate of outflows in the solar neighborhood is very high. In fact, regardless of considerations of cloud support, the large number of outflows identified in the Mon OB1 cloud and the propensity of the youngest stellar objects in the cloud to be associated with outflows suggest that outflows have a high birthrate in the solar neighborhood and are part of a common stage in early stellar evolution. The young stellar objects identified in the cloud can be fit into a spectral classification system. Also, the outflow phase in early stellar evolution tends to occur at about the time that young stellar objects lose a large fraction of their circumstellar envelopes

  1. The optical + infrared L dwarf spectral sequence of young planetary-mass objects in the Upper Scorpius association

    Science.gov (United States)

    Lodieu, N.; Zapatero Osorio, M. R.; Béjar, V. J. S.; Peña Ramírez, K.

    2018-01-01

    We present the results of photometric and spectroscopic follow-ups of the lowest mass member candidates in the nearest OB association, Upper Scorpius (∼5-10 Myr; 145 ± 17 pc), with the Gran Telescopio de Canarias (GTC) and European Southern Observatory (ESO) Very Large Telescope (VLT). We confirm the membership of the large majority (>80 per cent) of candidates originally selected photometrically and astrometrically based on their spectroscopic features, weak equivalent widths of gravity-sensitive doublets and radial velocities. Confirmed members follow a sequence over a wide magnitude range (J = 17.0-19.3 mag) in several colour-magnitude diagrams with optical, near- and mid-infrared photometry and have near-infrared spectral types in the L1-L7 interval with likely masses below 15 Jupiter masses. We find that optical spectral types tend to be earlier than near-infrared spectral types by a few subclasses for spectral types later than M9. We investigate the behaviour of spectral indices, defined in the literature as a function of spectral type and gravity, by comparison with values reported in the literature for young and old dwarfs. We also derive effective temperatures in the 1900-1600 K range from fits of synthetic model-atmosphere spectra to the observed photometry, but we caution that the procedure carries large uncertainties. We determine bolometric corrections for young L dwarfs with ages of ∼5-10 Myr (Upper Sco association) and find them to be similar in the J band but larger by 0.1-0.4 mag in the K band with respect to field L dwarfs. Finally, we discover two faint young L dwarfs, Visible and Infrared Survey Telescope for Astronomy (VISTA) J1607-2146 (L4.5) and VISTA J1611-2215 (L5), that have Hα emission and possible flux excesses at 4.5 μm, pointing to the presence of accretion from a disc on to the central objects of mass below ∼15MJup at an age of 5-10 Myr.

  2. Evaluation of the Architect HIV Ag/Ab Combo Assay in a low-prevalence setting: The role of samples with a low S/CO ratio.

    Science.gov (United States)

    Alonso, Roberto; Pérez-García, Felipe; Gijón, Paloma; Collazos, Ana; Bouza, Emilio

    2018-06-01

    The Architect HIV Ag/Ab Combo Assay, a fourth-generation ELISA, has proven to be highly reliable for the diagnosis of HIV infection. However, its high sensitivity may lead to false-positive results. To evaluate the diagnostic performance of Architect in a low-prevalence population and to assess the role of the sample-to-cutoff ratio (S/CO) in reducing the frequency of false-positive results. We conducted a retrospective study of samples analyzed by Architect between January 2015 and June 2017. Positive samples were confirmed by immunoblot (RIBA) or nucleic acid amplification tests (NAATs). Different S/CO thresholds (1, 2.5, 10, 25, and 100) were analyzed to determine sensitivity, specificity, and negative and positive predictive values (NPV, PPV). ROC analysis was used to determine the optimal S/CO. A total of 69,471 samples were analyzed. 709 (1.02%) were positive by Architect. Of these, 63 (8.89%) were false-positive results. Most of them (93.65%) were in samples with S/CO < 100. However, most confirmations by NAATs (12 out of 19 cases) were also recorded for these samples. The optimal S/CO was 2.5, which provided the highest area under the ROC curve (0.9998) and no false-negative results. With this S/CO, sensitivity and specificity were 100.0%, and PPV and NPV were 95.8% and 100.0%, respectively. In addition, the frequency of false-positive results decreased significantly to 4.15%. Although Architect generates a relatively high number of false-positive results, raising the S/CO limit too much to increase specificity can lead to false-negative results, especially in newly infected individuals. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. COLLIMATION AND ASYMMETRY OF THE HOT BLAST WAVE FROM THE RECURRENT NOVA V745 Sco

    Energy Technology Data Exchange (ETDEWEB)

    Drake, Jeremy J.; Kashyap, Vinay [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Delgado, Laura; Hernanz, M. [Institute of Space Sciences, ICE (CSIC-IEEC), E-08193 Cerdanyola del Vallés, Barcelona (Spain); Laming, J. Martin [Space Science Division, Naval Research Laboratory, Code 7674L, Washington, DC 20375 (United States); Starrfield, Sumner [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287-1404 (United States); Orlando, Salvatore [INAF—Osservatorio Astronomico di Palermo G. S. Vaiana, Piazza del Parlamento 1, I-90134 Palermo (Italy); Page, Kim L. [Department of Physics and Astronomy, University of Leicester, Leicester, LE1 7RH (United Kingdom); Ness, J.-U. [Science Operations Division, Science Operations Department of ESA, ESAC, E-28691 Villanueva de la Cañada (Madrid) (Spain); Gehrz, R. D.; Woodward, Charles E. [Minnesota Institute for Astrophysics, School of Physics and Astronomy, University of Minnesota, 116 Church Street SE, Minneapolis, MN 55455 (United States); Van Rossum, Daan [Flash Center for Computational Science, Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States)

    2016-07-10

    The recurrent symbiotic nova V745 Sco exploded on 2014 February 6 and was observed on February 22 and 23 by the Chandra X-ray Observatory Transmission Grating Spectrometers. By that time the supersoft source phase had already ended, and Chandra spectra are consistent with emission from a hot, shock-heated circumstellar medium with temperatures exceeding 10{sup 7} K. X-ray line profiles are more sharply peaked than expected for a spherically symmetric blast wave, with a full width at zero intensity of approximately 2400 km s{sup 1}, an FWHM of 1200 ± 30 km s{sup 1}, and an average net blueshift of 165 ± 10 km s{sup 1}. The red wings of lines are increasingly absorbed toward longer wavelengths by material within the remnant. We conclude that the blast wave was sculpted by an aspherical circumstellar medium in which an equatorial density enhancement plays a role, as in earlier symbiotic nova explosions. Expansion of the dominant X-ray-emitting material is aligned close to the plane of the sky and is most consistent with an orbit seen close to face-on. Comparison of an analytical blast wave model with the X-ray spectra, Swift observations, and near-infrared line widths indicates that the explosion energy was approximately 10{sup 43} erg and confirms an ejected mass of approximately 10{sup 7} M {sub ⊙}. The total mass lost is an order of magnitude lower than the accreted mass required to have initiated the explosion, indicating that the white dwarf is gaining mass and is a Type Ia supernova progenitor candidate.

  4. Development of selective catalytic oxidation (SCO) for NH{sub 3} and HCN removal from gasification gas; Selektiivisen katalyyttisen hapetusprosessin (SCO) kehittaeminen kaasutuskaasun NH{sub 3}:n ja HCN:n poistoon

    Energy Technology Data Exchange (ETDEWEB)

    Leppaelahti, J.; Koljonen, T.; Heiskanen, K. [VTT Energy, Espoo (Finland)

    1997-10-01

    In gasification, reactive nitrogen compounds (mainly NH{sub 3} and HCN) are formed from fuel nitrogen. If the gas containing NH{sub 3} is burned, a high NO{sub x} emission may be formed. The content of nitrogen compounds of the hot gasification gas could be reduced in Selective Catalytic Oxidation (SCO) process. In this process small amounts of reactive oxidisers are injected into the gas in order to convert NH{sub 3} to N{sub 2}. The utilization of SCO process together with low NO{sub x} burners in advanced gasification power stations might offer an alternative for flue gas treatment technologies like SCR (Selective Catalytic Reduction). In the earlier research, conditions were found, where oxidizers reacted selectively with ammonia in the gasification gas. Highest ammonia reduction took place in the aluminium oxide bed in the presence of NO and O{sub 2}. The aim of this study is to examine the reaction mechanism in order to be able to further evaluate the development possibilities of this kind process. The effect of composition and the amount of added oxidizer, the content of combustible gas components, space velocity, pressure and temperature will be studied. The experiments are carried out with the laboratory scale high pressure flow reactor of VTT Energy. Kinetic modelling of the experimental results is carried out in co-operation with the combustion chemistry group of Aabo Akademi. The aim of the modelling work is to bring insight to the gas-phase reactions that are important for the SCO-process. (orig.)

  5. Infrared spectroscopy of the remnant of Nova Sco 2014: a symbiotic star with too little circumstellar matter to decelerate the ejecta

    Science.gov (United States)

    Munari, U.; Banerjee, D. P. K.

    2018-03-01

    Pre-outburst 2MASS and WISE photometry of Nova Sco 2014 (V1534 Sco) has suggested the presence of a cool giant at the location of the nova in the sky. The spectral evolution recorded for the nova did not, however, support a direct partnership because no flash-ionized wind and no deceleration of the ejecta were observed, contrary to the behaviour displayed by other novae which erupted within symbiotic binaries like V407 Cyg or RS Oph. We have therefore obtained 0.8-2.5 μm spectra of the remnant of Nova Sco 2014 in order to ascertain if a cool giant is indeed present and if it is physically associated with the nova. The spectrum shows the presence of a M6III giant, reddened by E(B - V) = 1.20, displaying the typical and narrow emission-line spectrum of a symbiotic star, including He I 1.0830 μm with a deep P-Cyg profile. This makes Nova Sco 2014 a new member of the exclusive club of novae that erupt within a symbiotic binary. Nova Sco 2014 shows that a nova erupting within a symbiotic binary does not always come with a deceleration of the ejecta, contrary to the common belief. Many other similar systems may lay hidden in past novae, especially in those that erupted prior to the release of the 2MASS all-sky infrared survey, which could be profitably cross-matched now against them.

  6. Characterization of genetic diversity in chickpea using SSR markers, Start Codon Targeted Polymorphism (SCoT) and Conserved DNA-Derived Polymorphism (CDDP).

    Science.gov (United States)

    Hajibarat, Zahra; Saidi, Abbas; Hajibarat, Zohreh; Talebi, Reza

    2015-07-01

    To evaluate the genetic diversity among 48 genotypes of chickpea comprising cultivars, landraces and internationally developed improved lines genetic distances were evaluated using three different molecular marker techniques: Simple Sequence Repeat (SSR); Start Codon Targeted (SCoT) and Conserved DNA-derived Polymorphism (CDDP). Average polymorphism information content (PIC) for SSR, SCoT and CDDP markers was 0.47, 0.45 and 0.45, respectively, and this revealed that three different marker types were equal for the assessment of diversity amongst genotypes. Cluster analysis for SSR and SCoT divided the genotypes in to three distinct clusters and using CDDP markers data, genotypes grouped in to five clusters. There were positive significant correlation (r = 0.43, P SSR markers. These results suggest that efficiency of SSR, SCOT and CDDP markers was relatively the same in fingerprinting of chickpea genotypes. To our knowledge, this is the first detailed report of using targeted DNA region molecular marker (CDDP) for genetic diversity analysis in chickpea in comparison with SCoT and SSR markers. Overall, our results are able to prove the suitability of SCoT and CDDP markers for genetic diversity analysis in chickpea for their high rates of polymorphism and their potential for genome diversity and germplasm conservation.

  7. Development of an improved radiological basis and revised requirements for the transport of LSA/SCO materials

    International Nuclear Information System (INIS)

    Gray, I.L.S.; Lange, F.; Hoermann, E.; Carr, N.A.

    2004-01-01

    The IAEA Regulations for the Safe Transport of Radioactive Material specify a range of package requirements that are dependent upon the activity and properties of the radioactive material being transported. For example, Type A packages can be used for the transport of material with an activity of up to one A1 of special form material and one A2 of other material. The A1 and A2 values are determined for over 350 radionuclides using the Q system in the advisory material. This system models the following pathways in the event of a severe accident: External photon dose; External beta dose; Inhalation dose; Skin and ingestion dose due to contamination transfer; Submersion dose. Industrial packages can be used for the transport of low specific activity (LSA) material and surface contaminated objects (SCO) and the particular requirements for these types of materials are derived from a simplistic radiological model that is often referred to as the 10 mg inhalation model. This is because it is based on the assumption that, in a dusty environment, an individual would inhale no more than 10 mg in such a situation, although there is limited reliable information to justify this assumption. Furthermore, there are deficiencies in the specification of some of the material requirements for LSA/SCO material in the IAEA Transport Regulations. Consequently, this can cause some difficulties for operators in complying with the regulations and to competent authorities in their compliance assurance role. Particular areas of difficulty include: It can be difficult to distinguish between LSA-type material and SCO-type; It is difficult to distinguish surface contamination from activity within the object, and between fixed and nonfixed contamination; In order to demonstrate compliance with SCO requirements, measurements of both accessible and nonaccessible contamination are required, although it is not clear how compliance with the inaccessible contamination limit can be measured if it cannot

  8. Determining OBS Instrument Orientations: A Comparison of Algorithms

    Science.gov (United States)

    Doran, A. K.; Laske, G.

    2015-12-01

    The alignment of the orientation of the horizontal seismometer components with the geographical coordinate system is critical for a wide variety of seismic analyses, but the traditional deployment method of ocean bottom seismometers (OBS) precludes knowledge of this parameter. Current techniques for determining the orientation predominantly rely on body and surface wave data recorded from teleseismic events with sufficiently large magnitudes. Both wave types experience lateral refraction between the source and receiver as a result of heterogeneity and anisotropy, and therefore the arrival angle of any one phase can significantly deviate from the great circle minor arc. We systematically compare the results and uncertainties obtained through current determination methods, as well as describe a new algorithm that uses body wave, surface wave, and differential pressure gauge data (where available) to invert for horizontal orientation. To start with, our method is based on the easily transportable computer code of Stachnik et al. (2012) that is publicly available through IRIS. A major addition is that we utilize updated global dispersion maps to account for lateral refraction, as was done by Laske (1995). We also make measurements in a wide range of frequencies, and analyze surface wave trains of repeat orbits. Our method has the advantage of requiring fewer total events to achieve high precision estimates, which is beneficial for OBS deployments that can be as short as weeks. Although the program is designed for the purpose of use with OBS instruments, it also works with standard land installations. We intend to provide the community with a program that is easy to use, requires minimal user input, and is optimized to work with data cataloged at the IRIS DMC.

  9. A Search for Pulsar Companions to OB Runaway Stars

    Science.gov (United States)

    Kaspi, V. M.

    1995-01-01

    We have searched for radio pulsar companions to 40 nearby OB runaway stars. Observations were made at 474 and 770 MHz with the NRAO 140 ft telescope. The survey was sensitive to long- period pulsars with flux densities of 1 mJy or more. One previously unknown pulsar was discovered, PSRJ2044+4614, while observing towards target O star BD+45,3260. Follow-up timing observations of the pulsar measured its position to high precision, revealing a 9' separation between the pulsar and the target star, unequivocally indicating they are not associated.

  10. ObsPy - A Python Toolbox for Seismology - and Applications

    Science.gov (United States)

    Krischer, L.; Megies, T.; Barsch, R.; MacCarthy, J.; Lecocq, T.; Koymans, M. R.; Carothers, L.; Eulenfeld, T.; Reyes, C. G.; Falco, N.; Sales de Andrade, E.

    2017-12-01

    Recent years witnessed the evolution of Python's ecosystem into one of the most powerful and productive scientific environments across disciplines. ObsPy (https://www.obspy.org) is a fully community driven, open-source project dedicated to provide a bridge for seismology into that ecosystem. It is a Python toolbox offering: Read and write support for essentially every commonly used data format in seismology with a unified interface and automatic format detection. This includes waveform data (MiniSEED, SAC, SEG-Y, Reftek, …) as well as station (SEED, StationXML, SC3ML, …) and event meta information (QuakeML, ZMAP, …). Integrated access to the largest data centers, web services, and real-time data streams (FDSNWS, ArcLink, SeedLink, ...). A powerful signal processing toolbox tuned to the specific needs of seismologists. Utility functionality like travel time calculations with the TauP method, geodetic functions, and data visualizations. ObsPy has been in constant development for more than eight years and is developed and used by scientists around the world with successful applications in all branches of seismology. Additionally it nowadays serves as the foundation for a large number of more specialized packages. Newest features include: Full interoperability of SEED and StationXML/Inventory objects Access to the Nominal Response Library (NRL) for easy and quick creation of station metadata from scratch Support for the IRIS Federated Catalog Service Improved performance of the EarthWorm client Several improvements to MiniSEED read/write module Improved plotting capabilities for PPSD (spectrograms, PSD of discrete frequencies over time, ..) Support for.. Reading ArcLink Inventory XML Reading Reftek data format Writing SeisComp3 ML (SC3ML) Writing StationTXT format This presentation will give a short overview of the capabilities of ObsPy and point out several representative or new use cases and show-case some projects that are based on ObsPy, e.g.: seismo

  11. Assessment of genetic diversity in Vigna unguiculata L. (Walp) accessions using inter-simple sequence repeat (ISSR) and start codon targeted (SCoT) polymorphic markers.

    Science.gov (United States)

    Igwe, David Okeh; Afiukwa, Celestine Azubike; Ubi, Benjamin Ewa; Ogbu, Kenneth Idika; Ojuederie, Omena Bernard; Ude, George Nkem

    2017-11-17

    Assessment of genetic diversity of Vigna unguiculata (L.) Walp (cowpea) accessions using informative molecular markers is imperative for their genetic improvement and conservation. Use of efficacious molecular markers to obtain the required knowledge of the genetic diversity within the local and regional germplasm collections can enhance the overall effectiveness of cowpea improvement programs, hence, the comparative assessment of Inter-simple sequence repeat (ISSR) and Start codon targeted (SCoT) markers in genetic diversity of V. unguiculata accessions from different regions in Nigeria. Comparative analysis of the genetic diversity of eighteen accessions from different locations in Nigeria was investigated using ISSR and SCoT markers. DNA extraction was done using Zymogen Kit according to its manufacturer's instructions followed by amplifications with ISSR and SCoT and agarose gel electrophoresis. The reproducible bands were scored for analyses of dendrograms, principal component analysis, genetic diversity, allele frequency, polymorphic information content, and population structure. Both ISSR and SCoT markers resolved the accessions into five major clusters based on dendrogram and principal component analyses. Alleles of 32 and 52 were obtained with ISSR and SCoT, respectively. Numbers of alleles, gene diversity and polymorphic information content detected with ISSR were 9.4000, 0.7358 and 0.7192, while SCoT yielded 11.1667, 0.8158 and 0.8009, respectively. Polymorphic loci were 70 and 80 in ISSR and SCoT, respectively. Both markers produced high polymorphism (94.44-100%). The ranges of effective number of alleles (Ne) were 1.2887 ± 0.1797-1.7831 ± 0.2944 and 1.7416 ± 0.0776-1.9181 ± 0.2426 in ISSR and SCoT, respectively. The Nei's genetic diversity (H) ranged from 0.2112 ± 0.0600-0.4335 ± 0.1371 and 0.4111 ± 0.0226-0.4778 ± 0.1168 in ISSR and SCoT, respectively. Shannon's information index (I) from ISSR and SCoT were 0

  12. On the Binary Nature of Massive Blue Hypergiants: High-resolution X-Ray Spectroscopy Suggests That Cyg OB2 12 is a Colliding Wind Binary

    Energy Technology Data Exchange (ETDEWEB)

    Oskinova, L. M.; Hamann, W.-R.; Shenar, T.; Sander, A. A. C.; Todt, H.; Hainich, R. [Institute for Physics and Astronomy, University Potsdam, D-14476 Potsdam (Germany); Huenemoerder, D. P. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 70 Vassar St., Cambridge, MA 02139 (United States); Ignace, R., E-mail: lida@astro.physik.uni-potsdam.de [Department of Physics and Astronomy, East Tennessee State University, Johnson City, TN 37663 (United States)

    2017-08-10

    The blue hypergiant Cyg OB2 12 (B3Ia{sup +}) is a representative member of the class of very massive stars in a poorly understood evolutionary stage. We obtained its high-resolution X-ray spectrum using the Chandra observatory. PoWR model atmospheres were calculated to provide realistic wind opacities and to establish the wind density structure. We find that collisional de-excitation is the dominant mechanism depopulating the metastable upper levels of the forbidden lines of the He-like ions Si xiv and Mg xii. Comparison between the model and observations reveals that X-ray emission is produced in a dense plasma, which could reside only at the photosphere or in a colliding wind zone between binary components. The observed X-ray spectra are well-fitted by thermal plasma models, with average temperatures in excess of 10 MK. The wind speed in Cyg OB2 12 is not high enough to power such high temperatures, but the collision of two winds in a binary system can be sufficient. We used archival data to investigate the X-ray properties of other blue hypergiants. In general, stars of this class are not detected as X-ray sources. We suggest that our new Chandra observations of Cyg OB2 12 can be best explained if Cyg OB2 12 is a colliding wind binary possessing a late O-type companion. This makes Cyg OB2 12 only the second binary system among the 16 known Galactic hypergiants. This low binary fraction indicates that the blue hypergiants are likely products of massive binary evolution during which they either accreted a significant amount of mass or already merged with their companions.

  13. Modelling of slag emulsification and slag reduction in CAS-OB process

    OpenAIRE

    Sulasalmi, P. (Petri)

    2016-01-01

    Abstract Composition Adjustment by Sealed argon bubbling – Oxygen Blowing (CAS-OB) process is a ladle treatment process that was developed for chemical heating and alloying of steel. The main stages of the process are heating, (possible) alloying and reduction of slag. The CAS-OB process aims for homogenization and control of the composition and temperature of steel. In this dissertation, a mathematical reaction model was developed for the slag reduction stage of the CAS-OB process. Sl...

  14. AK SCO, FIRST DETECTION OF A HIGHLY DISTURBED ATMOSPHERE IN A PRE-MAIN-SEQUENCE CLOSE BINARY

    International Nuclear Information System (INIS)

    Gomez de Castro, Ana I.

    2009-01-01

    AK Sco is a unique source: a ∼10 Myr old pre-main-sequence (PMS) spectroscopic binary composed of two nearly equal F5 stars that at periastron are separated by barely 11 stellar radii, so the stellar magnetospheres fill the Roche lobe at periastron. The orbit is not yet circularized (e = 0.47) and very strong tides are expected. This makes AK Sco the ideal laboratory to study the effect of gravitational tides in the stellar magnetic field building up during PMS evolution. In this Letter, the detection of a highly disturbed (σ ≅ 100 km s -1 ) and very dense atmosphere (n e = 1.6 x 10 10 cm -3 ) is reported. Significant line broadening blurs any signs of ion belts or bow shocks in the spectrum of the atmospheric plasma. The radiative losses cannot be accounted for solely by the dissipation of energy from the tidal wave propagating in the stellar atmosphere or by the accreting material. The release of internal energy from the star seems to be the most likely source of the plasma heating. This is the first clear indication of a highly disturbed atmosphere surrounding a PMS close binary.

  15. AK Sco, First Detection of a Highly Disturbed Atmosphere in a Pre-Main-Sequence Close Binary

    Science.gov (United States)

    Gómez de Castro, Ana I.

    2009-06-01

    AK Sco is a unique source: a ~10 Myr old pre-main-sequence (PMS) spectroscopic binary composed of two nearly equal F5 stars that at periastron are separated by barely 11 stellar radii, so the stellar magnetospheres fill the Roche lobe at periastron. The orbit is not yet circularized (e = 0.47) and very strong tides are expected. This makes AK Sco the ideal laboratory to study the effect of gravitational tides in the stellar magnetic field building up during PMS evolution. In this Letter, the detection of a highly disturbed (σ sime 100 km s-1) and very dense atmosphere (n e = 1.6 × 1010 cm-3) is reported. Significant line broadening blurs any signs of ion belts or bow shocks in the spectrum of the atmospheric plasma. The radiative losses cannot be accounted for solely by the dissipation of energy from the tidal wave propagating in the stellar atmosphere or by the accreting material. The release of internal energy from the star seems to be the most likely source of the plasma heating. This is the first clear indication of a highly disturbed atmosphere surrounding a PMS close binary.

  16. The Seismic Broad Band Western Mediterranean (wm) Network and the Obs Fomar Pool: Current state and Obs activities.

    Science.gov (United States)

    Pazos, Antonio; Davila, Jose Martin; Buforn, Elisa; Bezzeghoud, Mourad; Harnafi, Mimoun; Mattesini, Mauricio; Caldeira, Bento; Hanka, Winfried; El Moudnib, Lahcen; Strollo, Angelo; Roca, Antoni; Lopez de Mesa, Mireya; Dahm, Torsten; Cabieces, Roberto

    2016-04-01

    The Western Mediterranean (WM) seismic network started in 1996 as an initiative of the Royal Spanish Navy Observatory (ROA) and the Universidad Complutense de Madrid (UCM), with the collaboration of the GeoForschungsZentrum (GFZ) of Potsdam. A first broad band seismic station (SFUC) was installed close to Cádiz (South Spain). Since then, additional stations have been installed in the Ibero-Moghrebian region. In 2005, the "WM" code was assigned by the FDSN and new partners were jointed: Evora University (UEVO, Portugal), the Scientifique Institute of Rabat (ISRABAT, Morocco), and GFZ. Now days, the WM network is composed by 15 BB stations, all of them with Streckaisen STS-2 or STS-2.5 sensors, Quanterra or Earthdata digitizers and SeiscomP. Most them have co-installed a permanent geodetic GPS stations, and some them also have an accelerometer. There are 10 stations deployed in Spanish territory (5 in the Iberian peninsula, 1 in Balearic islands and 4 in North Africa Spanish places) with VSAT or Internet communications, 2 in Portugal (one of them without real time), and 3 in Morocco (2 VSAT and 1 ADSL). Additionally, 2 more stations (one in South Spain and one in Morocco) will be installed along this year. Additionally ROA has deployed a permanent real time VBB (CMG-3T: 360s) station at the Alboran Island. Due to the fact that part of the seismic activity is located at marine areas, and also because of the poor geographic azimuthal coverage at some zones provided by the land stations (specially in the SW of the San Vicente Cape area), ROA and UCM have acquired six broad band "LOBSTERN" OBS, manufactured by KUM (Kiel, Germany), conforming the OBS FOMAR pool. Three of them with CMG-40T sensor and the other with Trillium 120. These OBS were deployed along the Gibraltar strait since January to November 2014 to study the microseismicity in the Gibraltar strait area. In September 2015 FOMAR network has been deployed in SW of the San Vicente Cape for 8 months as a part of

  17. Dietary Capsaicin Improves Glucose Homeostasis and Alters the Gut Microbiota in Obese Diabetic ob/ob Mice

    Directory of Open Access Journals (Sweden)

    Jun-Xian Song

    2017-08-01

    Full Text Available Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown. This study aimed to investigate the potential relationship between the regulation of obesity and glucose homeostasis by dietary capsaicin and the alterations of gut microbiota in obese diabetic ob/ob mice.Methods: The ob/ob mice were subjected to a normal, low-capsaicin (0.01%, or high-capsaicin (0.02% diet for 6 weeks, respectively. Obesity phenotypes, glucose homeostasis, the gut microbiota structure and composition, short-chain fatty acids, gastrointestinal hormones, and pro-inflammatory cytokines were measured.Results: Both the low- and high-capsaicin diets failed to prevent the increase in body weight, adiposity index, and Lee's obesity index. However, dietary capsaicin at both the low and high doses significantly inhibited the increase of fasting blood glucose and insulin levels. These inhibitory effects were comparable between the two groups. Similarly, dietary capsaicin resulted in remarkable improvement in glucose and insulin tolerance. In addition, neither the low- nor high-capsaicin diet could alter the α-diversity and β-diversity of the gut microbiota. Taxonomy-based analysis showed that both the low- and high-capsaicin diets, acting in similar ways, significantly increased the Firmicutes/Bacteroidetes ratio at the phylum level as well as increased the Roseburia abundance and decreased the Bacteroides and Parabacteroides abundances at the genus level. Spearman's correlation analysis revealed that the Roseburia abundance was negatively while the Bacteroides and Parabacteroides abundances were positively correlated to the fasting blood glucose level and area under the curve by the oral glucose tolerance test. Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-α, IL-1

  18. Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure.

    Science.gov (United States)

    Krisko, Tibor I; LeClair, Katherine B; Cohen, David E

    2017-03-01

    Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is highly expressed in liver and oxidative tissues. PC-TP promotes hepatic glucose production during fasting and aggravates glucose intolerance in high fat fed mice. However, because PC-TP also suppresses thermogenesis in brown adipose tissue (BAT), its direct contribution to obesity-associated diabetes in mice remains unclear. Here we examined the effects of genetic PC-TP ablation on glucose homeostasis in leptin-deficient ob/ob mice, which exhibit both diabetes and altered thermoregulation. Mice lacking both PC-TP and leptin (Pctp -/- ;ob/ob) were prepared by crossing Pctp -/- with ob/+ mice. Glucose homeostasis was assessed by standard assays, and energy expenditure was determined by indirect calorimetry using a comprehensive laboratory animal monitoring system, which also recorded physical activity and food intake. Body composition was determined by NMR and hepatic lipids by enzymatic assays. Core body temperature was measured using a rectal thermocouple probe. Pctp -/- ;ob/ob mice demonstrated improved glucose homeostasis, as evidenced by markedly improved glucose and pyruvate tolerance tests, without changes in insulin tolerance. However, there were no differences in EE at any ambient temperature. There were also no effects of PC-TP expression on physical activity, food intake or core body temperature. Improved glucose tolerance in Pctp -/- ;ob/ob mice in the absence of increases in energy expenditure or core body temperature indicates a direct pathogenic role for PC-TP in diabetes in leptin deficient mice. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Decreased triiodothyronine receptor binding in skeletal muscle nuclei and erythrocyte membranes of obese (ob/ob) mice

    International Nuclear Information System (INIS)

    Gilvary, E.P.

    1988-01-01

    Hindlimb skeletal muscle weights and binding of L-tri-iodothyronine (T 3 ) to isolated nuclei of this tissue were investigated in obese (ob/ob) mice and their lean littermates. Maximal binding capacities (Bmax) and dissociation constants (Kd) were determined by incubating isolated muscle nuclei with increasing conc. of 125 I-T 3 (0.4 nM to 4nM). At 12 wks. of age, although weighing substantially more, obese mice had only 55% as much muscle mass as their lean littermates. There was no phenotype effect observed for Kd, however, Bmax was significantly less for the obese mice. In a second experiment, a 16-wk. feeding study was conducted with 4 groups of mice according to the following design: lean mice fed rodent chow; obese mice fed rodent chow; obese mice, n-6 fatty acid (FA)-rich diet; and obese mice, n-3FA-rich diet. Erythrocyte T 3 receptor binding capacities were measured by incubating red cell ghosts from mice of these 4 groups with 125 I-T 3 . As with skeletal muscle nuclei there were no phenotype effects observed for Kd between any two groups. In contrasts obese mice fed chow and n-6FA-rich diets both exhibited lower Bmax than their lean counterparts, while no significant difference was observed between the latter group and the obese mice fed an n-3FA-rich diet. Bmax values of the n-6 group were also decreased compared to the n-3 group

  20. Oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics: Immunofluorescent localization in the mouse hypothalamus.

    Science.gov (United States)

    Anderson, Brian M; Jacobson, Lauren; Novakovic, Zachary M; Grasso, Patricia

    2017-06-01

    This study describes the localization of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, synthetic peptide leptin mimetics, in the hypothalamus of Swiss Webster and C57BL/6J wild-type mice, leptin-deficient ob/ob mice, and leptin-resistant diet-induced obese (DIO) mice. The mice were given [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in 0.3% dodecyl maltoside by oral gavage. Once peak serum concentrations were reached, the mice received a lethal dose of pentobarbital and were subjected to intracardiac perfusion fixation. The brains were excised, post-fixed in paraformaldehyde, and cryo-protected in sucrose. Free-floating frozen coronal sections were cut at 25-µm and processed for imaging by immunofluorescence microscopy. In all four strains of mice, dense staining was concentrated in the area of the median eminence, at the base and/or along the inner wall of the third ventricle, and in the brain parenchyma at the level of the arcuate nucleus. These results indicate that [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 cross the blood-brain barrier and concentrate in an area of the hypothalamus known to regulate energy balance and glucose homeostasis. Most noteworthy is the localization of [D-Leu-4]-OB3 immunoreactivity within the hypothalamus of DIO mice via a conduit that is closed to leptin in this rodent model, and in most cases of human obesity. Together with our previous studies describing the effects of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on energy balance, glucose regulation, and signal transduction pathway activation, these findings are consistent with a central mechanism of action for these synthetic peptide leptin mimetics, and suggest their potential usefulness in the management of leptin-resistant obesity and type 2 diabetes in humans. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Mass loss rates of OB stars derived from infrared observations

    International Nuclear Information System (INIS)

    Tanzi, E.G.; Tarenghi, M.; Panagia, N.

    1981-01-01

    In this paper the authors report briefly on a study of the mass loss of early type stars in the infrared. Up to now near infrared (1.25 - 4.8 μ) broad band photometry of 70 southern OB stars of various luminosity class has been secured. Program stars have been selected, among those bright enough in the infrared to give a suitable photometric accuracy, in order to cover a wide range of spectral types. 37 stars are found to exhibit emission in excess over a blackbody photospheric continuum, which is interpreted in terms of gas ejected in the form of an accelerated wind. By means of model calculations the corresponding mass loss rates are derived. The obtained values compare well with those determined independently by various authors for stars in common. Their data show that mass loss rates increase with luminosity and are a decreasing function of surface gravity. (Auth.)

  2. Dropping Probability Reduction in OBS Networks: A Simple Approach

    KAUST Repository

    Elrasad, Amr

    2016-08-01

    In this paper, we propose and derive a slotted-time model for analyzing the burst blocking probability in Optical Burst Switched (OBS) networks. We evaluated the immediate and delayed signaling reservation schemes. The proposed model compares the performance of both just-in-time (JIT) and just-enough-time (JET) signaling protocols associated with of void/non-void filling link scheduling schemes. It also considers none and limited range wavelength conversions scenarios. Our model is distinguished by being adaptable to different offset-time and burst length distributions. We observed that applying a limited range of wavelength conversion, burst blocking probability is reduced by several orders of magnitudes and yields a better burst delivery ratio compared with full wavelength conversion.

  3. Performance analysis of signaling protocols on OBS switches

    Science.gov (United States)

    Kirci, Pinar; Zaim, A. Halim

    2005-10-01

    In this paper, Just-In-Time (JIT), Just-Enough-Time (JET) and Horizon signalling schemes for Optical Burst Switched Networks (OBS) are presented. These signaling schemes run over a core dWDM network and a network architecture based on Optical Burst Switches (OBS) is proposed to support IP, ATM and Burst traffic. In IP and ATM traffic several packets are assembled in a single packet called burst and the burst contention is handled by burst dropping. The burst length distribution in IP traffic is arbitrary between 0 and 1, and is fixed in ATM traffic at 0,5. Burst traffic on the other hand is arbitrary between 1 and 5. The Setup and Setup ack length distributions are arbitrary. We apply the Poisson model with rate λ and Self-Similar model with pareto distribution rate α to identify inter-arrival times in these protocols. We consider a communication between a source client node and a destination client node over an ingress and one or more multiple intermediate switches.We use buffering only in the ingress node. The communication is based on single burst connections in which, the connection is set up just before sending a burst and then closed as soon as the burst is sent. Our analysis accounts for several important parameters, including the burst setup, burst setup ack, keepalive messages and the optical switching protocol. We compare the performance of the three signalling schemes on the network under as burst dropping probability under a range of network scenarios.

  4. Observations of mass loss from OB and Wolf-Rayet stars

    International Nuclear Information System (INIS)

    Barlow, M.J.

    1982-01-01

    In this review, three observationally accessible parameters of the winds of OB and Wolf-Rayet stars are discussed: (1) Terminal velocities, (2) Velocity laws, (3) Mass loss rates. In addition, some discussion of the ionisation structure of the winds is included. In general, only the most recent results for OB stars are mentioned. (Auth.)

  5. ANTI-TERROR POLICY OF UZBEKISTAN IN THE FRAMEWORK OF THE REGIONAL ANTI-TERRORIST POLICY OF THE SCO

    Directory of Open Access Journals (Sweden)

    С П Базылева

    2017-12-01

    Full Text Available The beginning of the XXI century was marked by a number of serious problems, including cancer, world hunger, environmental problems and increasing every year the problem of global terrorism, which poses a great threat to the security of the modern multipolar world. Uzbekistan today occupies a firm position in fight against terrorist threat. The principled position of Uzbekistan in the fight against terrorism is that “no country should exclude their participation in the fight against global terrorism, there must be no transit zones and "green corridors" for terrorist organizations”. The Central Asian region is one of the most vulnerable, because it is necessary to pay special attention to the strategy of the anti-terrorist security of the countries included in the structure of the Central Asian region. In this article, we consider the anti-terrorist policy of Uzbekistan in the framework of the regional anti-terrorist policy of the SCO.

  6. Systematic Correlation Matrix Evaluation (SCoMaE) - a bottom-up, science-led approach to identifying indicators

    Science.gov (United States)

    Mengis, Nadine; Keller, David P.; Oschlies, Andreas

    2018-01-01

    This study introduces the Systematic Correlation Matrix Evaluation (SCoMaE) method, a bottom-up approach which combines expert judgment and statistical information to systematically select transparent, nonredundant indicators for a comprehensive assessment of the state of the Earth system. The methods consists of two basic steps: (1) the calculation of a correlation matrix among variables relevant for a given research question and (2) the systematic evaluation of the matrix, to identify clusters of variables with similar behavior and respective mutually independent indicators. Optional further analysis steps include (3) the interpretation of the identified clusters, enabling a learning effect from the selection of indicators, (4) testing the robustness of identified clusters with respect to changes in forcing or boundary conditions, (5) enabling a comparative assessment of varying scenarios by constructing and evaluating a common correlation matrix, and (6) the inclusion of expert judgment, for example, to prescribe indicators, to allow for considerations other than statistical consistency. The example application of the SCoMaE method to Earth system model output forced by different CO2 emission scenarios reveals the necessity of reevaluating indicators identified in a historical scenario simulation for an accurate assessment of an intermediate-high, as well as a business-as-usual, climate change scenario simulation. This necessity arises from changes in prevailing correlations in the Earth system under varying climate forcing. For a comparative assessment of the three climate change scenarios, we construct and evaluate a common correlation matrix, in which we identify robust correlations between variables across the three considered scenarios.

  7. Genetic Diversity and Association of EST-SSR and SCoT Markers with Rust Traits in Orchardgrass (Dactylis glomerata L.).

    Science.gov (United States)

    Yan, Haidong; Zhang, Yu; Zeng, Bing; Yin, Guohua; Zhang, Xinquan; Ji, Yang; Huang, Linkai; Jiang, Xiaomei; Liu, Xinchun; Peng, Yan; Ma, Xiao; Yan, Yanhong

    2016-01-08

    Orchardgrass (Dactylis glomerata L.), is a well-known perennial forage species; however, rust diseases have caused a noticeable reduction in the quality and production of orchardgrass. In this study, genetic diversity was assessed and the marker-trait associations for rust were examined using 18 EST-SSR and 21 SCoT markers in 75 orchardgrass accessions. A high level of genetic diversity was detected in orchardgrass with an average genetic diversity index of 0.369. For the EST-SSR and SCoT markers, 164 and 289 total bands were obtained, of which 148 (90.24%) and 272 (94.12%) were polymorphic, respectively. Results from an AMOVA analysis showed that more genetic variance existed within populations (87.57%) than among populations (12.43%). Using a parameter marker index, the efficiencies of the EST-SSR and SCoT markers were compared to show that SCoTs have higher marker efficiency (8.07) than EST-SSRs (4.82). The results of a UPGMA cluster analysis and a STRUCTURE analysis were both correlated with the geographic distribution of the orchardgrass accessions. Linkage disequilibrium analysis revealed an average r² of 0.1627 across all band pairs, indicating a high extent of linkage disequilibrium in the material. An association analysis between the rust trait and 410 bands from the EST-SSR and SCoT markers using TASSEL software revealed 20 band panels were associated with the rust trait in both 2011 and 2012. The 20 bands obtained from association analysis could be used in breeding programs for lineage selection to prevent great losses of orchardgrass caused by rust, and provide valuable information for further association mapping using this collection of orchardgrass.

  8. Constraining formation of the Eggvin Bank (West of Jan Mayen, N. Atlantic) from OBS data

    Science.gov (United States)

    Tan, P.; Breivik, A. J.; Mjelde, R.; Azuma, R.

    2015-12-01

    The anomalously high magma flux in the Eggvin Bank area has triggered new research efforts to better understand the crustal development in this area. The Eggvin Bank is located between the Jan Mayen Island and the west coast of Greenland. Some proposed origins of the Eggvin Bank are: a distinct plume located beneath Jan Mayen; an extension of the Iceland plume; minor spreading or leakage along West Jan Mayen Fracture Zone (WJMFZ); intruded continental crust extending from Jan Mayen Microcontinent (JMMC); and rifted Greenland sub-continental lithospheric mantle. In this first modern refraction seismic study of the Eggvin Bank, we present a 2D velocity model based on OBS data. The OBSs were deployed approx. N-S over the Eggvin Bank with good data quality constrained by 4 OBSs. The air-gun array used during OBS shooting produced good quality reflection data. Three distinct seamounts are observed along the profile: the northern seamount (water depth 730m), has a flat top with a thin sedimentary veneer on top, which indicates it has been eroded at sea surface; while the southern two seamounts, one (water depth 550m) is less flat with around 100m thick sedimentary units on top, another one is rounded with tiny sedimentary veneer on top having the shallowest water depth (460m). This could suggest that the southern seamounts are younger, since they are shallower but without obvious signs that they were subaerially exposed. However, increased cooling of the lithosphere across the WJMFZ in the north may also contribute to depth differences. A normal fault offsetting sedimentary strata (~300 m) in the Greenland Basin indicates recent tectonic activity north of the Eggvin Bank. The velocity modeling shows crustal thickness with large variations, ranging from 8 km to 14 km, where crustal thickness changes of 4-5 km are associated with 20-30 km wide segments with thick crust under the seamounts. The crust consists of three oceanic crustal layers: upper crust (2.8km/s-4.8km

  9. COSMIC ORIGINS SPECTROGRAPH OBSERVATIONS OF TRANSLUCENT CLOUDS: Cyg OB2 8A

    International Nuclear Information System (INIS)

    Snow, Theodore P.; Destree, Joshua D.; Burgh, Eric B.; Ferguson, Ryan M.; Danforth, Charles W.; Cordiner, Martin

    2010-01-01

    Data from the Cosmic Origins Spectrograph (COS) are presented for the first highly reddened target (Cyg OB2 8A) under the COS Science Team's guaranteed time allocation. Column densities of ionic, atomic, and molecular species are reported and implications are discussed. Data from Cyg OB2 8A demonstrate the ability to analyze highly reddened interstellar sight lines with the COS that were unavailable to previous UV instruments. Measured column densities indicate that the Cyg OB2 8A line of sight contains multiple diffuse clouds rather than a dominant translucent cloud.

  10. Study of clumping in the Cepheus OB 3 molecular cloud

    International Nuclear Information System (INIS)

    Carr, J.S.

    1987-01-01

    A portion of the Cep OB 3 molecular cloud has been mapped in the (C-13)O (1-0) line on a completely sampled grid with a 1.5-arcmin spacing. A total of 45 individual clouds, or clumps, have been identified in the map, with masses from 3 to 300 solar mass, sizes 3 pc or smaller, and mean densities of a few hundred/cu cm. Power-law correlations are found among the clump properties, namely, M proportional to R exp 2.5 and Delta(v) exp 0.24. These exponents differ somewhat from those found for similar correlations for molecular clouds in previous studies. Determination of the virial masses for the clumps shows that the clumps are not gravitationally bound and must be expanding on a time scale of about 1 Myr. Measurements of the (C-13)O (2-1) line give volume densities of 2000-5000. Comparisons of these densities with the mean volume densities from the (C-13)O (1-0) data suggest that the gas is clumped on a small scale with a volume filling factor of 0.04-0.10. 31 references

  11. A Novel Congestion Detection Scheme in TCP Over OBS Networks

    KAUST Repository

    Shihada, Basem

    2009-02-01

    This paper introduces a novel congestion detection scheme for high-bandwidth TCP flows over optical burst switching (OBS) networks, called statistical additive increase multiplicative decrease (SAIMD). SAIMD maintains and analyzes a number of previous round-trip time (RTTs) at the TCP senders in order to identify the confidence with which a packet loss event is due to network congestion. The confidence is derived by positioning short-term RTT in the spectrum of long-term historical RTTs. The derived confidence corresponding to the packet loss is then taken in the developed policy for TCP congestion window adjustment. We will show through extensive simulation that the proposed scheme can effectively solve the false congestion detection problem and significantly outperform the conventional TCP counterparts without losing fairness. The advantages gained in our scheme are at the expense of introducing more overhead in the SAIMD TCP senders. Based on the proposed congestion control algorithm, a throughput model is formulated, and is further verified by simulation results.

  12. Influences of obese (ob/ob and diabetes (db/db genotype mutations on lumber vertebral radiological and morphometric indices: Skeletal deformation associated with dysregulated systemic glucometabolism

    Directory of Open Access Journals (Sweden)

    Garris David R

    2006-02-01

    Full Text Available Abstract Background Both diabetes and obesity syndromes are recognized to promote lumbar vertebral instability, premature osteodegeneration, exacerbate progressive osteoporosis and increase the propensity towards vertebral degeneration, instability and deformation in humans. Methods The influences of single-gene missense mutations, expressing either diabetes (db/db or obese (ob/ob metabolic syndromes on vertebral maturation and development in C57BL/KsJ mice were evaluated by radiological and macro-morphometric analysis of the resulting variances in osteodevelopment indices relative to control parameters between 8 and 16 weeks of age (syndrome onset @ 4 weeks, and the influences of low-dose 17-B-estradiol therapy on vertebral growth expression evaluated. Results Associated with the indicative genotypic obesity and hyper-glycemic/-insulinemic states, both db/db and ob/ob mutants demonstrated a significant (P ≤ 0.05 elongation of total lumbar vertebrae column (VC regional length, and individual lumbar vertebrae (LV1-5 lengths, relative to control VC and LV parameters. In contrast, LV1-5 width indices were suppressed in db/db and ob/ob mutants relative to control LV growth rates. Between 8 and 16 weeks of age, the suppressed LV1-5 width indices were sustained in both genotype mutant groups relative to control osteomaturation rates. The severity of LV1-5 width osteosuppression correlated with the severe systemic hyperglycemic and hypertriglyceridemic conditions sustained in ob/ob and db/db mutants. Low-dose 17-B-estradiol therapy (E2-HRx: 1.0 ug/ 0.1 ml oil s.c/3.5 days, initiated at 4 weeks of age (i.e., initial onset phase of db/db and ob/ob expressions re-established control LV 1–5 width indices without influencing VC or LV lengths in db/db groups. Conclusion These data demonstrate that the abnormal systemic endometabolic states associated with the expression of db/db and ob/ob genomutation syndromes suppress LV 1–5 width osteomaturation

  13. Expression of the P2X2 receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse

    Science.gov (United States)

    Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Castelucci, Patricia

    2012-01-01

    AIM: To examine whether the ob/ob mouse model of obesity is accompanied by enteric nervous system abnormalities such as altered motility. METHODS: The study examined the distribution of the P2X2 receptor (P2X2R) in myenteric neurons of female ob/ob mice. Specifically, we used immunohistochemistry to analyze the co-expression of the P2X2R with neuronal nitric oxide synthase (nNOS), choline acetyltransferase (ChAT), and calretinin (CalR) in neurons of the small intestine myenteric plexus in ob/ob and control female mice. In these sections, we used scanning confocal microscopy to analyze the co-localization of these markers as well as the neuronal density (cm2) and area profile (μm²) of P2X2R-positive neurons. In addition, enteric neurons were labeled using the nicotinamide adenine dinucleotide (NADH) diaphorase method and analyzed with light microscopy as an alternate means by which to analyze neuronal density and area. RESULTS: In the present study, we observed a 29.6% increase in the body weight of the ob/ob animals (OG) compared to the control group (CG). In addition, the average small intestine area was increased by approximately 29.6% in the OG compared to the CG. Immunoreactivity (IR) for the P2X2R, nNOS, ChAT and CalR was detectable in the myenteric plexus, as well as in the smooth muscle, in both groups. This IR appeared to be mainly cytoplasmic and was also associated with the cell membrane of the myenteric plexus neurons, where it outlined the neuronal cell bodies and their processes. P2X2R-IR was observed to co-localize 100% with that for nNOS, ChAT and CalR in neurons of both groups. In the ob/ob group, however, we observed that the neuronal density (neuron/cm2) of P2X2R-IR cells was increased by 62% compared to CG, while that of NOS-IR and ChAT-IR neurons was reduced by 49% and 57%, respectively, compared to control mice. The neuronal density of CalR-IR neurons was not different between the groups. Morphometric studies further demonstrated that the

  14. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice.

    Science.gov (United States)

    Huang, S-L; Yu, R-T; Gong, J; Feng, Y; Dai, Y-L; Hu, F; Hu, Y-H; Tao, Y-D; Leng, Y

    2012-05-01

    Arctigenin is a natural compound that had never been previously demonstrated to have a glucose-lowering effect. Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. 2-Deoxyglucose uptake and AMPK phosphorylation were examined in L6 myotubes and isolated skeletal muscle. Gluconeogenesis and lipid synthesis were evaluated in rat primary hepatocytes. The acute and chronic effects of arctigenin on metabolic abnormalities were observed in C57BL/6J and ob/ob mice. Changes in mitochondrial membrane potential were measured using the J-aggregate-forming dye, JC-1. Analysis of respiration of L6 myotubes or isolated mitochondria was conducted in a channel oxygen system. Arctigenin increased AMPK phosphorylation and stimulated glucose uptake in L6 myotubes and isolated skeletal muscles. In primary hepatocytes, it decreased gluconeogenesis and lipid synthesis. The enhancement of glucose uptake and suppression of hepatic gluconeogenesis and lipid synthesis by arctigenin were prevented by blockade of AMPK activation. The respiration of L6 myotubes or isolated mitochondria was inhibited by arctigenin with a specific effect on respiratory complex I. A single oral dose of arctigenin reduced gluconeogenesis in C57BL/6J mice. Chronic oral administration of arctigenin lowered blood glucose and improved lipid metabolism in ob/ob mice. This study demonstrates a new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes.

  15. [Detection of psychosocial dysfunction in ob-gyn patients].

    Science.gov (United States)

    González-Forteza, C F; Morales Carmona, F; Gutiérrez Calderon, E

    1993-01-01

    The human behavior and its social determinants are critical variables for understanding the etiology, treatment, and prevention of many disorders previously attributed to biological substrates. Among the many categories of human behavior to receive special attention from health researchers and practitioners are life events, coping responses and emotional state. The relation between these categories constituted a particular field of investigation. This relationship rather than forcing to focus on disease, distress, disability, and other failures in human functioning, permits to address health, abilities, resources, and other positive aspects of human functioning. On the other hand, the re-organization of health services considers interdisciplinary work as an objective, as it is necessary to care for the patient in an integral manner, with the consequent benefit of a more efficient service. In addition it is known that patients with psychosocial dysfunctions who use general practice care facilities overutilize these services in an unnecessary manner. With this in mind it is clear that is necessary to balance the service's cost-benefit for a more efficient clinical attention. In this paper we present the results of the categories mentioned above: life events, coping responses and its relationship with emotional state in a representative sample of 399 female patients who in 1986 received services at the National Institute of Perinatology-INPer-. Of these patients, 297 were obstetrical patients -OBS- and 102 gynaecological ones -GINE-. All patients answered these instruments: General Health Questionnaire -GHQ-7 of 30 items, a subscale of Health and Daily Living for Coping Responses and Life Events Scale.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. A CATALOG OF NEW SPECTROSCOPICALLY CONFIRMED MASSIVE OB STARS IN CARINA

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, Michael J.; Hanes, Richard J.; McSwain, M. Virginia [Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015 (United States); Povich, Matthew S., E-mail: alexamic@lafayette.edu, E-mail: rjh314@lehigh.edu, E-mail: mcswain@lehigh.edu, E-mail: mspovich@cpp.edu [Department of Physics and Astronomy, California State Polytechnic University, Pomona, CA 91768 (United States)

    2016-12-01

    The Carina star-forming region is one of the largest in the Galaxy, and its massive star population is still being unveiled. The large number of stars combined with high, and highly variable, interstellar extinction makes it inherently difficult to find OB stars in this type of young region. We present the results of a spectroscopic campaign to study the massive star population of the Carina Nebula, with the primary goal to confirm or reject previously identified Carina OB star candidates. A total of 141 known O- and B-type stars and 94 candidates were observed, of which 73 candidates had high enough signal-to-noise ratio to classify. We find 23 new OB stars within the Carina Nebula, a 32% confirmation rate. One of the new OB stars has blended spectra and is suspected to be a double-lined spectroscopic binary (SB2). We also reclassify the spectral types of the known OB stars and discover nine new SB2s among this population. Finally, we discuss the spatial distribution of these new OB stars relative to known structures in the Carina Nebula.

  17. The third flight of CHESS: Preliminary analysis of interstellar H2 on the β1 Sco sightline

    Science.gov (United States)

    Kruczek, Nick; France, Kevin

    2018-01-01

    We describe the scientific motivation and technical development of the Colorado High-resolution Echelle Stellar Spectrograph (CHESS), focusing on the preliminary science results for the third launch of the payload (CHESS-3). CHESS is a far ultraviolet rocket-borne instrument designed to study the atomic-to-molecular transitions within translucent cloud regions in the interstellar medium. CHESS is an objective echelle spectrograph, which uses a mechanically-ruled echelle and a powered (f/12.4) cross-dispersing grating, and is designed to achieve a resolving power R > 100,000 over the band pass λλ 1000-1600 Å. CHESS-3 launched on 14 June 2017 aboard NASA/CU sounding rocket mission 36.323 UG. The target for the flight was β1 Sco, a B1V star with a sightline that is likely sampling translucent material. We present flight results of interstellar molecular hydrogen excitation, including initial measurements of the column density and temperature, on the sightline.

  18. Early X- and HE γ-ray emission from the symbiotic recurrent novae V745 Sco & RS Oph.

    Science.gov (United States)

    Delgado, L.; Hernanz, M.

    2017-10-01

    RS Oph was the first nova for which evidence of particle acceleration during its 2006 outburst was found. In recent years, several nova explosions - eight classical and two symbiotic recurrent novae - have been detected by Fermi/LAT at E>100 MeV. In most cases, this emission has been observed early after the explosion, around the optical maximum, and for a short period of time. The high-energy γ-ray emission is a consequence of π^{0} decay and/or Inverse Compton, which are related to particle (p and e^{-}) acceleration in the strong shock between the nova ejecta and the circumstellar matter. Our aim is to understand the acceleration process through the analysis of contemporaneous X-ray emission, and in particular, through the evolution of the shock wave. A deep analysis of early X-ray observations of the symbiotic recurrent novae V745 Sco (2014) by Swift/XRT, Chandra/HETG and NuStar, and RS Oph (2006) by XMM-Newton/EPIC and RGS, Swift/XRT and BAT and RXTE/PCA is presented taking into account the contemporaneous information from the IR and radio observations. This provides for the first time a global view of the early evolution of a nova remnant and its relationship with particle acceleration.

  19. Radionuclides in the Ob/Irtysh river system and their contribution to pollution of the Arctic

    International Nuclear Information System (INIS)

    Trapeznikov, A.; Pozolotina, V.; Trapeznikova, V.; Yushkov, P.; Polikarpov, G.; Aarkrog, A.; Nielsen, S.P.

    1995-01-01

    The aims of this study were: 1) to continue the investigation of distribution of radionuclides in the principal components of the Techa river, and 2) to get the first estimate of the contamination of sediments of the Iset, Tobol, Irtysh and Ob rivers. The samples from the Irtysh river were collected in 1993 nine km in front of confluence of the Irtysh with the Ob river. The mean Cs-137 concentration in the sediments did not show any clear trend. The sediments from the Ob river were collected in 1992 near Labitnangi, situated about 300 km from the outlet of the Ob into the Kara Sea. In 1994 samples were collected five km in front of and five km after confluence with the Irtysh river. All results are summarized in a table. It appears that the Cs-137 levels in the Ob sediments, before and after confluence with Irtysh, do not change significantly. It is difficult to see any systematic changes in Cs-137 concentrations with depth. In some cases the top five cm show higher concentrations than the deeper layers. 7 refs., 1 tab

  20. Search for OB stars running away from young star clusters. I. NGC 6611

    Science.gov (United States)

    Gvaramadze, V. V.; Bomans, D. J.

    2008-11-01

    N-body simulations have shown that the dynamical decay of the young (~1 Myr) Orion Nebula cluster could be responsible for the loss of at least half of its initial content of OB stars. This result suggests that other young stellar systems could also lose a significant fraction of their massive stars at the very beginning of their evolution. To confirm this expectation, we used the Mid-Infrared Galactic Plane Survey (completed by the Midcourse Space Experiment satellite) to search for bow shocks around a number of young (⪉several Myr) clusters and OB associations. We discovered dozens of bow shocks generated by OB stars running away from these stellar systems, supporting the idea of significant dynamical loss of OB stars. In this paper, we report the discovery of three bow shocks produced by O-type stars ejected from the open cluster NGC 6611 (M16). One of the bow shocks is associated with the O9.5Iab star HD165319, which was suggested to be one of “the best examples for isolated Galactic high-mass star formation” (de Wit et al. 2005, A&A, 437, 247). Possible implications of our results for the origin of field OB stars are discussed.

  1. Production of metal and metal-ceramic coatings on D-Gun Ob

    International Nuclear Information System (INIS)

    Gavrilenko, T.P.; Nikolaev, Y.A.; Ulianitsky, V.Y.

    1995-01-01

    Optimization of the detonation spraying process has been made for the production of metal and metal-ceramics coatings with the D-Gun Ob. Owing to the ability of Ob to work with several fuels and an inert diluent simultaneously, variation of detonation regimes in a wide range is possible, and because of localized powder injection in the D-Gun barrel, high uniformity of parameters of powder particles is achieved. The best conditions for particle heating and acceleration were calculated with the help of mathematical simulation, and the corresponding regimes were realized on D-Gun Ob. High-quality aluminum, copper, nickel, and nickel-chromium-silicon-carbon-boron alloy coatings were produced by using only propane fuel. Chromium carbide with nickel and tungsten carbide with cobalt coatings were produced with addition of acetylene. Optimal efficiency and high bonding strength were achieved for all powders. Data on microhardness, bonding strength, and efficiency are presented

  2. The performance study of oxide by-passed(OB) lateral double diffused MOSFET

    Science.gov (United States)

    Tang, Pan-pan

    2016-10-01

    An SOI LDMOS device structure with Oxide By-passed(OB) was investigated and its breakdown mechanism and characteristic of structure was analyzed. Its performance was verified by 3D numerical simulation with SILVACO TCAD software. The simulated results show that the electrical field element of the device is modulated by the concept of similar Superjunction(SJ) structure. Compared with the SJ LDMOS device, OB LDMOS obtains the same breakdown voltage, simultaneously the specific on-resistance of the OB LDMOS reduces from 3.81mΩ·cm2 to 1.96mΩ·cm2, except for achieving comparable performance and overcoming the high aspect ratio of fabrication structure and the difficulty of accurate concentration match of SJ LDMOS.

  3. ESTIMATION OF BURSTS LENGTH AND DESIGN OF A FIBER DELAY LINE BASED OBS ROUTER

    Directory of Open Access Journals (Sweden)

    RICHA AWASTHI

    2017-03-01

    Full Text Available The demand for higher bandwidth is increasing day by day and this ever growing demand cannot be catered to with current electronic technology. Thus new communication technology like optical communication needs to be used. In the similar context OBS (optical burst switching is considered as next generation data transfer technology. In OBS information is transmitted in forms of optical bursts of variable lengths. However, contention among the bursts is a major problem in OBS system, and for contention resolution defection routing is mostly preferred. However, deflection routing increases delay. In this paper, it is shown that the arrival of very large bursts is rare event, and for moderate burst length the buffering of contending burst can provide very effective solution. However, in case of arrival of large bursts deflection can be used.

  4. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha

    DEFF Research Database (Denmark)

    Hwang, C S; Mandrup, S; MacDougald, O A

    1996-01-01

    Like other adipocyte genes that are transcriptionally activated by CCAAT/enhancer binding protein alpha (C/EBP alpha) during preadipocyte differentiation, expression of the mouse obese (ob) gene is immediately preceded by the expression of C/EBP alpha. While the 5' flanking region of the mouse ob...... gene contains several consensus C/EBP binding sites, only one of these sites appears to be functional. DNase I cleavage inhibition patterns (footprinting) of the ob gene promoter revealed that recombinant C/EBP alpha, as well as a nuclear factor present in fully differentiated 3T3-L1 adipocytes...... to a consensus C/EBP binding site at nucleotides -55 to -47 generated a specific protein-oligonucleotide complex that was supershifted by antibody against C/EBP alpha. Probes corresponding to two upstream consensus C/EBP binding sites failed to generate protein-oligonucleotide complexes. Cotransfection of a C...

  5. NEAR INFRARED DIFFUSE INTERSTELLAR BANDS TOWARD THE CYGNUS OB2 ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Hamano, Satoshi; Kondo, Sohei; Sameshima, Hiroaki; Nakanishi, Kenshi; Kawakita, Hideyo [Laboratory of Infrared High-resolution Spectroscopy, Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Kobayashi, Naoto [Institute of Astronomy, School of Science, University of Tokyo, 2-21-1 Osawa, Mitaka, Tokyo 181-0015 (Japan); Ikeda, Yuji [Photocoding, 460-102 Iwakura-Nakamachi, Sakyo-ku, Kyoto, 606-0025 (Japan); Yasui, Chikako; Mizumoto, Misaki; Matsunaga, Noriyuki; Fukue, Kei; Yamamoto, Ryo; Izumi, Natsuko [Department of Astronomy, Graduate School of Science, University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mito, Hiroyuki [Kiso Observatory, Institute of Astronomy, School of Science, The University of Tokyo, 10762-30 Mitake, Kiso-machi, Kiso-gun, Nagano, 397-0101 (Japan); Nakaoka, Tetsuya; Kawanishi, Takafumi; Kitano, Ayaka; Otsubo, Shogo [Department of Physics, Faculty of Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Kinoshita, Masaomi, E-mail: hamano@cc.kyoto-su.ac.jp [Solar-Terrestrial Environment Laboratory, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi, 464-8601 (Japan)

    2016-04-10

    We obtained the near-infrared (NIR) high-resolution (R ≡ λ/Δλ ∼ 20,000) spectra of the seven brightest early-type stars in the Cygnus OB2 association for investigating the environmental dependence of diffuse interstellar bands (DIBs). The WINERED spectrograph mounted on the Araki 1.3 m telescope in Japan was used to collect data. All 20 of the known DIBs within the wavelength coverage of WINERED (0.91 < λ < 1.36 μm) were clearly detected along all lines of sight because of their high flux density in the NIR wavelength range and the large extinction. The equivalent widths (EWs) of DIBs were not correlated with the column densities of C{sub 2} molecules, which trace the patchy dense component, suggesting that the NIR DIB carriers are distributed mainly in the diffuse component. On the basis of the correlations among the NIR DIBs both for stars in Cyg OB2 and stars observed previously, λλ10780, 10792, 11797, 12623, and 13175 are found to constitute a “family,” in which the DIBs are correlated well over the wide EW range. In contrast, the EW of λ10504 is found to remain almost constant over the stars in Cyg OB2. The extinction estimated from the average EW of λ10504 (A{sub V} ∼ 3.6 mag) roughly corresponds to the lower limit of the extinction distribution of OB stars in Cyg OB2. This suggests that λ10504 is absorbed only by the foreground clouds, implying that the carrier of λ10504 is completely destroyed in Cyg OB2, probably by the strong UV radiation field. The different behaviors of the DIBs may be caused by different properties of the DIB carriers.

  6. Preliminary Studies of Two-Phase Reactive Process of Sodium-CO2 in S-CO2 Power Conversion Cycle Coupled to SFR System

    International Nuclear Information System (INIS)

    Jung, Hwa Young; Ahn, Yoon Han; Lee, You Ho; Lee, Jeong Ik

    2013-01-01

    As a competing alternative to the steam Rankine cycle, the supercritical CO 2 (S-CO 2 ) Brayton cycle has been highlighted due to its high thermal efficiency, compact turbomachinery and heat exchangers sizes, and the reduced risk of SWRs. While the reduced risk of an SWR is considered as the one of most pronounced benefits of S-CO 2 Brayton cycle, there is still an interaction problem between liquid sodium and CO 2 . Although the chemical interaction between liquid sodium and CO 2 demonstrates less serious potential risks than those of a SWR, the Na/CO 2 interaction should be understood to evaluate safety and reliability of Intermediate Heat eXchanger (IHX). A noticeable characteristic of the reaction environment is that there is a large pressure difference between the liquid sodium and CO 2 side by about 1 and 200 bar, respectively. This would imply that the presence of a micro-crack in a heat exchanger tube will cause a high-pressure leak of CO 2 into liquid sodium side. Although the Na/CO 2 interaction may play an important role in the safety of the SFR reactor system, there has not yet been any research on understanding Na/CO 2 reaction by leakage through IHX. For this problem, the Korea Advanced Institute of Science and Technology (KAIST) research team is studying the mechanism of CO 2 leakage and Na/CO 2 interaction in more details. The KAIST research team developed the MATLAB code, KAIST H XD, which can be used to design and evaluate performance of a heat exchanger of an S-CO 2 cycle. The size of heat exchanger and the amount of CO 2 in the cycle are calculated from the KAIST H XD code to estimate the amount of reaction products in Na/CO 2 interaction as well as liquid sodium

  7. Magnetic field of massive chemically peculiar stars in the Orion OB1 association

    Science.gov (United States)

    Romanyuk, I. I.; Semenko, E. A.; Kudryavtsev, D. O.; Yakunin, I. A.

    2018-01-01

    Spectropolarimetric observations of 55 chemically peculiar stars in the Orion OB1 association were obtained at the 6 m telescope of the Russian Academy of Sciences with the aim of searching for the presence of stellar magnetic fields. We found 8 new magnetic stars in addition to 20 previously known objects. The frequency of chemically peculiar A and B-type stars among normal A and B-type stars and the frequency of magnetic stars among all chemically peculiar stars decreases with age in the Orion OB1 association.

  8. Analyzing the Effects of Nitrogen Deficiency on the PHB Production of Methylosinus trichosporium OB3b

    Science.gov (United States)

    Kyauk, E.

    2011-12-01

    Polyhydroxybutyrate (PHB) is a biodegradable thermoplastic that is produced by various microorganisms. Because of its potential to replace conventional plastics, it has been closely researched in the past few years. Methanotrophic bacteria, bacteria that consume methane, produce this bioplastic when it lacks certain nutrients. The utilization of methane to produce PHB shows much promise as methane is a cheap, plentiful gas. In this study, we observed the methanotroph, Methylosinus trichosporium OB3b , and its yield of PHB in the absence of nitrogen. The optical density of Methylosinus trichosporium OB3b was measured in order to observe cell growth and PHB production patterns over a 48 hour period.

  9. Standard operating procedures for collection of soil and sediment samples for the Sediment-bound Contaminant Resiliency and Response (SCoRR) strategy pilot study

    Science.gov (United States)

    Fisher, Shawn C.; Reilly, Timothy J.; Jones, Daniel K.; Benzel, William M.; Griffin, Dale W.; Loftin, Keith A.; Iwanowicz, Luke R.; Cohl, Jonathan A.

    2015-12-17

    An understanding of the effects on human and ecological health brought by major coastal storms or flooding events is typically limited because of a lack of regionally consistent baseline and trends data in locations proximal to potential contaminant sources and mitigation activities, sensitive ecosystems, and recreational facilities where exposures are probable. In an attempt to close this gap, the U.S. Geological Survey (USGS) has implemented the Sediment-bound Contaminant Resiliency and Response (SCoRR) strategy pilot study to collect regional sediment-quality data prior to and in response to future coastal storms. The standard operating procedure (SOP) detailed in this document serves as the sample-collection protocol for the SCoRR strategy by providing step-by-step instructions for site preparation, sample collection and processing, and shipping of soil and surficial sediment (for example, bed sediment, marsh sediment, or beach material). The objectives of the SCoRR strategy pilot study are (1) to create a baseline of soil-, sand-, marsh sediment-, and bed-sediment-quality data from sites located in the coastal counties from Maine to Virginia based on their potential risk of being contaminated in the event of a major coastal storm or flooding (defined as Resiliency mode); and (2) respond to major coastal storms and flooding by reoccupying select baseline sites and sampling within days of the event (defined as Response mode). For both modes, samples are collected in a consistent manner to minimize bias and maximize quality control by ensuring that all sampling personnel across the region collect, document, and process soil and sediment samples following the procedures outlined in this SOP. Samples are analyzed using four USGS-developed screening methods—inorganic geochemistry, organic geochemistry, pathogens, and biological assays—which are also outlined in this SOP. Because the SCoRR strategy employs a multi-metric approach for sample analyses, this

  10. Advective transport observations with MODPATH-OBS--documentation of the MODPATH observation process

    Science.gov (United States)

    Hanson, R.T.; Kauffman, L.K.; Hill, M.C.; Dickinson, J.E.; Mehl, S.W.

    2013-01-01

    The MODPATH-OBS computer program described in this report is designed to calculate simulated equivalents for observations related to advective groundwater transport that can be represented in a quantitative way by using simulated particle-tracking data. The simulated equivalents supported by MODPATH-OBS are (1) distance from a source location at a defined time, or proximity to an observed location; (2) time of travel from an initial location to defined locations, areas, or volumes of the simulated system; (3) concentrations used to simulate groundwater age; and (4) percentages of water derived from contributing source areas. Although particle tracking only simulates the advective component of conservative transport, effects of non-conservative processes such as retardation can be approximated through manipulation of the effective-porosity value used to calculate velocity based on the properties of selected conservative tracers. This program can also account for simple decay or production, but it cannot account for diffusion. Dispersion can be represented through direct simulation of subsurface heterogeneity and the use of many particles. MODPATH-OBS acts as a postprocessor to MODPATH, so that the sequence of model runs generally required is MODFLOW, MODPATH, and MODPATH-OBS. The version of MODFLOW and MODPATH that support the version of MODPATH-OBS presented in this report are MODFLOW-2005 or MODFLOW-LGR, and MODPATH-LGR. MODFLOW-LGR is derived from MODFLOW-2005, MODPATH 5, and MODPATH 6 and supports local grid refinement. MODPATH-LGR is derived from MODPATH 5. It supports the forward and backward tracking of particles through locally refined grids and provides the output needed for MODPATH_OBS. For a single grid and no observations, MODPATH-LGR results are equivalent to MODPATH 5. MODPATH-LGR and MODPATH-OBS simulations can use nearly all of the capabilities of MODFLOW-2005 and MODFLOW-LGR; for example, simulations may be steady-state, transient, or a combination

  11. [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3, small molecule synthetic peptide leptin mimetics, improve glycemic control in diet-induced obese (DIO) mice.

    Science.gov (United States)

    Wang, Anke; Anderson, Brian M; Novakovic, Zachary M; Grasso, Patricia

    2018-03-01

    We have previously shown that following oral delivery in dodecyl maltoside (DDM), [D-Leu-4]-OB3 and its myristic acid conjugate, MA-[D-Leu-4]-OB3, improved energy balance and glucose homeostasis in genetically obese/diabetic mouse models. More recently, we have provided immunohistochemical evidence indicating that these synthetic peptide leptin mimetics cross the blood-brain barrier and concentrate in the area of the arcuate nucleus of the hypothalamus in normal C57BL/6J and Swiss Webster mice, in genetically obese ob/ob mice, and in diet-induced obese (DIO) mice. In the present study, we describe the effects of oral delivery of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on glycemic control in diet-induced (DIO) mice, a non-genetic rodent model of obesity and its associated insulin resistance, which more closely recapitulates common obesity and diabetes in humans. Male C57BL/6J and DIO mice, 17, 20, and 28 weeks of age, were maintained on a low-fat or high-fat diet and given vehicle (DDM) alone or [D-Leu-4]-OB3 or MA-[D-Leu-4]-OB3 in DDM by oral gavage for 12 or 14 days. Body weight gain, food and water intake, fasting blood glucose, oral glucose tolerance, and serum insulin levels were measured. Our data indicate that (1) [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 restore glucose tolerance in male DIO mice maintained on a high-fat diet to levels comparable to those of non-obese C57BL/6J wild-type mice of the same age and sex maintained on a low-fat diet; and (2) the influence of [D-Leu-4]-OB3 and MA-[D-Leu-4]-OB3 on glycemic control appears to be independent of their effects on energy balance. These results suggest that [D-Leu-4]-OB3 and/or MA-[D-Leu-4]-OB3 may have application to the management of the majority of cases of common obesity in humans, a state characterized at least in part, by leptin resistance resulting from a defect in leptin transport across the blood-brain barrier. They further suggest that these small molecule synthetic peptide leptin mimetics, through their

  12. Conversion of chlorinated propanes by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase

    NARCIS (Netherlands)

    Bosma, T.; Janssen, D.B.

    Chlorinated propanes are important pollutants that may show persistent behaviour in the environment. The biotransformation of 1-chloropropane, 1,2-dichloropropane, 1,3-dichloropropane and 1,2,3-trichloropropane was studied using resting cell suspensions of Methylosinus trichosporium OB3b expressing

  13. Formation of massive stars in OB associations and giant molecular clouds

    International Nuclear Information System (INIS)

    Lada, C.J.

    1980-01-01

    Certain interesting patterns are being perceived in the morphology of the regions which have recently produced massive OB stars. In particular, current evidence seems to favour the notion that the formation of massive stars takes place at the edges and not the centres of large molecular cloud complexes. It is this aspect of the observations that is discussed in the present paper. The phenomena described here will pertain to massive stars only. Specifically, stars with spectral types earlier than B3 will be considered since it is usually only these stars that produce sufficient havoc (e.g., maser sources, CO bright spots, H II regions) to noticeably affect their early environments. The corresponding phenomena for lower mass stars could be entirely different. A review is first presented of what has been learned about the OB star formation process from studies of the visible OB stars themselves. Then, newly derived information pertaining to the most recent episodes of OB star birth in galactic molecular clouds is discussed. Finally, a short discussion of the significance of the results and their implications for possible star formation mechanisms will be made. (U.K.)

  14. Degradation of Chlorinated Aliphatic Hydrocarbons by Methylosinus trichosporium OB3b Expressing Soluble Methane Monooxygenase

    NARCIS (Netherlands)

    Oldenhuis, R.; Vink, Ruud L.J.M.; Janssen, D. B.; Witholt, B.

    1989-01-01

    Degradation of trichloroethylene (TCE) by the methanotrophic bacterium Methylosinus trichosporium OB3b was studied by using cells grown in continuous culture. TCE degradation was a strictly cometabolic process, requiring the presence of a cosubstrate, preferably formate, and oxygen. M. trichosporium

  15. Inter-Division IV/V WG on Active OB Stars

    NARCIS (Netherlands)

    Owocki, S.; Aerts, C.; Fabregat, J.; Gies, D.; Henrichs, H.F.; McDavid, D.; Porter, J.; Rivinius, T.; Peters, G.; Stefl, S.

    2007-01-01

    Our group studies active early-type (OB) stars, with historical focus on classical Be stars, but extending in recent years to include Slowly Pulsating B-stars (SPB), Beta-Cephei stars, the strongly magnetic Bp stars, Luminous Blue Vairiable (LBV) stars, and B[e] stars. An overall goal is to

  16. Kinetics of Chlorinated Hydrocarbon Degradation by Methylosinus trichosporium OB3b and Toxicity of Trichloroethylene

    NARCIS (Netherlands)

    Oldenhuis, Roelof; Oedzes, Johannes Y.; Waarde, Jacob J. van der; Janssen, Dick B.

    The kinetics of the degradation of trichloroethylene (TCE) and seven other chlorinated aliphatic hydrocarbons by Methylosinus trichosporium OB3b were studied. All experiments were performed with cells grown under copper stress and thus expressing soluble methane monooxygenase. Compounds that were

  17. VizieR Online Data Catalog: Velocity and proper motion of OB associations (Melnik+, 2009)

    Science.gov (United States)

    Melnik, A. M.; Dambis, A. K.

    2009-11-01

    For every OB-association from the list by Blaha and Humphreys (1989AJ.....98.1598B) we give the mean galactic coordinates l and b, the mean heliocentric distance r, median line-of-sight velocity Vr, the dispersion of line-of-sight velocities dvr, and number of stars with known line-of-sight velocity nvr. The line-of-sight velocities were taken from the catalog by Barbier-Brossat and Figon (1999, Cat. ). We used only the velocities measured with errors of less than 10km/s which corresponds to the quality estimations A, B, and C. We also present median proper motions of OB-associations along l- and b- coordinates, mul and mub. The data obtained for the old reduction (1997, Cat. ) are denoted by the subscript 1, whereas those based on the reduction by van Leewen (2008, Cat. ) are marked by the subscript 2. For each OB association we represent the dispersions of proper motions, dml and dmb, as well as a number of stars nmu with known proper motion. The last column shows the total number of stars with known photometric measurements, Nt, used for determination of the distances for OB-associations. The distances r correspond to the short distance scale for classical Cepheids. They are equal to the distances from the catalog by Blaha and Humphreys (1989AJ.....98.1598B), rBH, multiplied by a factor of 0.8, r=0.8*rBH. (1 data file).

  18. High rate of vaginal erosions associated with the mentor ObTape.

    Science.gov (United States)

    Yamada, Brian S; Govier, Fred E; Stefanovic, Ksenija B; Kobashi, Kathleen C

    2006-08-01

    The transobturator tape method is a newer surgical technique for the treatment of stress urinary incontinence. Limited data exist related to complications with this approach or the types of mesh products used. We report our experience with vaginal erosions associated with the Mentor ObTape and American Medical Systems Monarc transobturator slings. Beginning in December 2003 selected female patients with anatomic urinary incontinence were prospectively followed after placement of the Mentor ObTape. Beginning in January 2004 we also began using the American Medical Systems Monarc in similar patients. Patients were admitted overnight after surgery, discharged on oral antibiotics, and seen in the clinic at 6 weeks postoperatively. A total of 67 patients have undergone placement of the Mentor ObTape and 9 of those patients (13.4%) have had vaginal extrusions of the sling. Eight patients reported a history of persistent vaginal discharge. One patient presented initially to an outside facility with a left thigh abscess tracking to the left inguinal incision site. Each patient was taken back to the operating room for mesh removal. A total of 56 patients have undergone placement of the AMS Monarc and none have had any vaginal erosions. Our high rate of vaginal extrusion using the ObTape has led us to discontinue the use of this product in our institution. Continued followup of all of these patients will be of critical importance.

  19. ObsPack: a framework for the preparation, delivery, and attribution of atmospheric greenhouse gas data

    NARCIS (Netherlands)

    Masarie, K. A.; Peters, W.; Jacobson, A. R.; Tans, P. P.

    2014-01-01

    Observation Package (ObsPack) is a framework designed to bring together atmospheric greenhouse gas observations from a variety of sampling platforms, prepare them with specific applications in mind, and package and distribute them in a self-consistent and well-documented product. Data products

  20. ObsPack: a framework for the preparation, delivery, and attribution of atmospheric greenhouse gas measurements

    NARCIS (Netherlands)

    Masarie, K. A.; Peters, W.; Jacobson, A. R.; Tans, P. P.

    2014-01-01

    Observation Package (ObsPack) is a framework designed to bring together atmospheric greenhouse gas observations from a variety of sampling platforms, prepare them with specific applications in mind, and package and distribute them in a self-consistent and well-documented product. Data products

  1. Effect of chlorinated ethene conversion on viability and activity of Methylosinus trichosporium OB3b

    NARCIS (Netherlands)

    van Hylckama Vlieg, Johan E.T.; Koning, Wim de; Janssen, Dick B.

    1997-01-01

    The effect of transformation of chlorinated ethenes on the cell viability of Methylosinus trichosporium OB3b was investigated. A comparison of the loss of viability with the decrease in transformation rates shelved that for the monooxygenase-mediated transformation of all chlorinated ethenes except

  2. Analytical model of a burst assembly algorithm for the VBR in the OBS networks

    International Nuclear Information System (INIS)

    Shargabi, M.A.A.; Mellah, H.; Abid, A.

    2008-01-01

    This paper presents a proposed analytical model for the number of bursts aggregated in a period of time in OBS networks. The model considers the case of VBR traffic with two different sending rates, which are SCR and PCR. The model is validated using extensive simulations. Where results from simulations are in total agreement with the results obtained by the proposed model. (author)

  3. Mass loss from OB supergiants in x-ray binary systems

    International Nuclear Information System (INIS)

    Alme, M.L.; Wilson, J.R.

    1975-01-01

    A study of the atmospheres of OB supergiants in x-ray binary systems indicates that when the stellar surface is close enough to the saddle in the gravitational potential to provide a mass transfer rate adequate to power a compact x-ray source, large-amplitude variations in the rate of mass flow occur. 9 references

  4. BOREAS TF-3 NSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    Science.gov (United States)

    Wofsy, Steven; Sutton, Doug; Goulden, Mike; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-3) team collected tower flux, surface meteorological, and soil temperature data at the BOREAS Northern Study Area-Old Black Spruce (NSA-OBS) site continuously from the March 1994 through October 1996. The data are available in tabular ASCII files.

  5. Development of a Performance Analysis Code for the Off-design conditions of a S-CO2 Brayton Cycle Energy Conversion System

    International Nuclear Information System (INIS)

    Yoo, Yong-Hwan; Cha, Jae-Eun; Lee, Tae-Ho; Eoh, Jae-Hyuk; Kim, Seong-O

    2008-01-01

    For the development of a supercritical carbon dioxide (S-CO2) Brayton cycle energy conversion system coupled to KALIMER-600, a thermal balance has been established on 100% power operating conditions including all the reactor system models such as a primary heat transport system (PHTS), an intermediate heat transport system (IHTS), and an energy conversion system. The S-CO2 Brayton cycle energy conversion system consists of a sodium-CO2 heat exchanger (Hx), turbine, high temperature recuperate (HTR), low temperature recuperate (LTR), precooler, compressor no.1, and compressor no.2. Two compressors were employed to avoid a sharp change of the physical properties near their critical point with a corresponding pressure. The component locations and their operating conditions are illustrated. Energy balance of the power conversion system in KALIMER-600 was designed with the full power condition of each component. Therefore, to predict the off-design conditions and to evaluate each component, an off-design performance analysis code should be accomplished. An off-design performance analysis could be classified into overall system control logic and local system control logic. The former means that mass flow rate and power are controlled by valves, and the latter implies that a bypass or inventory control is an admitted system balance. The ultimate goal of this study is development of the overall system control logic

  6. The cardiac copper chaperone proteins Sco1 and CCS are up-regulated, but Cox 1 and Cox4 are down-regulated, by copper deficiency.

    Science.gov (United States)

    Getz, Jean; Lin, Dingbo; Medeiros, Denis M

    2011-10-01

    Copper is ferried in a cell complexed to chaperone proteins, and in the heart much copper is required for cytochrome c oxidase (Cox). It is not completely understood how copper status affects the levels of these proteins. Here we determined if dietary copper deficiency could up- or down-regulate select copper chaperone proteins and Cox subunits 1 and 4 in cardiac tissue of rats. Sixteen weanling male Long-Evans rats were randomized into treatment groups, one group receiving a copper-deficient diet (CCS, Sco1, Ctr1, Cox17, Cox1, and Cox4 by SDS-PAGE and Western blotting. No changes were observed in the concentrations of CTR1 and Cox17 between copper-adequate and copper-deficient rats. CCS and Sco1 were up-regulated and Cox1 and Cox4 were both down-regulated as a result of copper deficiency. These data suggest that select chaperone proteins and may be up-regulated, and Cox1 and 4 down-regulated, by a dietary copper deficiency, whereas others appear not to be affected by copper status.

  7. The Overt Behaviour Scale-Self-Report (OBS-SR) for acquired brain injury: exploratory analysis of reliability and validity.

    Science.gov (United States)

    Kelly, Glenn; Simpson, Grahame K; Brown, Suzanne; Kremer, Peter; Gillett, Lauren

    2017-05-23

    The objectives were to test the properties, via a psychometric study, of the Overt Behaviour Scale-Self-Report (OBS-SR), a version of the OBS-Adult Scale developed to provide a client perspective on challenging behaviours after acquired brain injury. Study sample 1 consisted of 37 patients with primary brain tumour (PBT) and a family-member informant. Sample 2 consisted of 34 clients with other acquired brain injury (mixed brain injury, MBI) and a service-provider informant. Participants completed the OBS-SR (at two time points), and the Awareness Questionnaire (AQ) and Mayo Portland Adaptability Inventory-III (MPAI-III) once; informants completed the OBS-Adult and AQ once only. PBT-informant dyads displayed "good" levels of agreement (ICC 2,k  = .74; OBS-SR global index). Although MBI-informant dyads displayed no agreement (ICC 2,k  = .22; OBS-SR global index), the sub-group (17/29) rated by clinicians as having moderate to good levels of awareness displayed "fair" agreement (ICC 2,k  = .58; OBS-SR global index). Convergent/divergent validity was demonstrated by significant correlations between OBS-SR subscales and MPAI-III subscales with behavioural content (coefficients in the range .36 -.61). Scores had good reliability across one week (ICC 2,k  = .69). The OBS-SR took approximately 15 minutes to complete. It was concluded that the OBS-SR demonstrated acceptable reliability and validity, providing a useful resource in understanding clients' perspectives about their behaviour.

  8. Spacer type mediated tunable spin crossover (SCO) characteristics of pyrene decorated 2,6-bis(pyrazol-1-yl)pyridine (bpp) based Fe(ii) molecular spintronic modules.

    Science.gov (United States)

    Kumar, Kuppusamy Senthil; Šalitroš, Ivan; Moreno-Pineda, Eufemio; Ruben, Mario

    2017-08-14

    A simple "isomer-like" variation of the spacer group in a set of Fe(ii) spin crossover (SCO) complexes designed to probe spin state dependence of electrical conductivity in graphene-based molecular spintronic junctions led to the observation of remarkable variations in the thermal- and light-induced magnetic characteristics, paving a simple route for the design of functional SCO complexes with different temperature switching regimes based on a 2,6-bis(pyrazol-1-yl)pyridine ligand skeleton.

  9. ObsPy: A Python toolbox for seismology - Sustainability, New Features, and Applications

    Science.gov (United States)

    Krischer, L.; Megies, T.; Sales de Andrade, E.; Barsch, R.; MacCarthy, J.

    2016-12-01

    ObsPy (https://www.obspy.org) is a community-driven, open-source project dedicated to offer a bridge for seismology into the scientific Python ecosystem. Amongst other things, it provides Read and write support for essentially every commonly used data format in seismology with a unified interface. This includes waveform data as well as station and event meta information. A signal processing toolbox tuned to the specific needs of seismologists. Integrated access to the largest data centers, web services, and databases. Wrappers around third party codes like libmseed and evalresp. Using ObsPy enables users to take advantage of the vast scientific ecosystem that has developed around Python. In contrast to many other programming languages and tools, Python is simple enough to enable an exploratory and interactive coding style desired by many scientists. At the same time it is a full-fledged programming language usable by software engineers to build complex and large programs. This combination makes it very suitable for use in seismology where research code often must be translated to stable and production ready environments, especially in the age of big data. ObsPy has seen constant development for more than six years and enjoys a large rate of adoption in the seismological community with thousands of users. Successful applications include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. Additionally it sparked the development of several more specialized packages slowly building a modern seismological ecosystem around it. We will present a short overview of the capabilities of ObsPy and point out several representative use cases and more specialized software built around ObsPy. Additionally we will discuss new and upcoming features, as well as the sustainability of open-source scientific software.

  10. Structure-function analysis of the OB and latch domains of chlorella virus DNA ligase.

    Science.gov (United States)

    Samai, Poulami; Shuman, Stewart

    2011-06-24

    Chlorella virus DNA ligase (ChVLig) is a minimized eukaryal ATP-dependent DNA sealing enzyme with an intrinsic nick-sensing function. ChVLig consists of three structural domains, nucleotidyltransferase (NTase), OB-fold, and latch, that envelop the nicked DNA as a C-shaped protein clamp. The OB domain engages the DNA minor groove on the face of the duplex behind the nick, and it makes contacts to amino acids in the NTase domain surrounding the ligase active site. The latch module occupies the DNA major groove flanking the nick. Residues at the tip of the latch contact the NTase domain to close the ligase clamp. Here we performed a structure-guided mutational analysis of the OB and latch domains. Alanine scanning defined seven individual amino acids as essential in vivo (Lys-274, Arg-285, Phe-286, and Val-288 in the OB domain; Asn-214, Phe-215, and Tyr-217 in the latch), after which structure-activity relations were clarified by conservative substitutions. Biochemical tests of the composite nick sealing reaction and of each of the three chemical steps of the ligation pathway highlighted the importance of Arg-285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions. Phe-286 interacts with the nick 5'-phosphate nucleotide and the 3'-OH base pair and distorts the DNA helical conformation at the nick. Arg-285 is a key component of the OB-NTase interface, where it forms a salt bridge to the essential Asp-29 side chain, which is imputed to coordinate divalent metal catalysts during the nick sealing steps.

  11. Structure-Function Analysis of the OB and Latch Domains of Chlorella Virus DNA Ligase*

    Science.gov (United States)

    Samai, Poulami; Shuman, Stewart

    2011-01-01

    Chlorella virus DNA ligase (ChVLig) is a minimized eukaryal ATP-dependent DNA sealing enzyme with an intrinsic nick-sensing function. ChVLig consists of three structural domains, nucleotidyltransferase (NTase), OB-fold, and latch, that envelop the nicked DNA as a C-shaped protein clamp. The OB domain engages the DNA minor groove on the face of the duplex behind the nick, and it makes contacts to amino acids in the NTase domain surrounding the ligase active site. The latch module occupies the DNA major groove flanking the nick. Residues at the tip of the latch contact the NTase domain to close the ligase clamp. Here we performed a structure-guided mutational analysis of the OB and latch domains. Alanine scanning defined seven individual amino acids as essential in vivo (Lys-274, Arg-285, Phe-286, and Val-288 in the OB domain; Asn-214, Phe-215, and Tyr-217 in the latch), after which structure-activity relations were clarified by conservative substitutions. Biochemical tests of the composite nick sealing reaction and of each of the three chemical steps of the ligation pathway highlighted the importance of Arg-285 and Phe-286 in the catalysis of the DNA adenylylation and phosphodiester synthesis reactions. Phe-286 interacts with the nick 5′-phosphate nucleotide and the 3′-OH base pair and distorts the DNA helical conformation at the nick. Arg-285 is a key component of the OB-NTase interface, where it forms a salt bridge to the essential Asp-29 side chain, which is imputed to coordinate divalent metal catalysts during the nick sealing steps. PMID:21527793

  12. Photoionization of the diffuse interstellar medium and galactic halo by OB associtations

    Science.gov (United States)

    Dove, James B.; Shull, J. Michael

    1994-01-01

    Assuming smoothly varying H I distributions in te Galactic disk, we have calculated the geometry of diffuse II regions due to OB associations in the Galactic plane. Near the solar circle, OB associations with a Lyman continuum (Lyc) photon luminosity Psi(sub Lyc) = 3.3 x 10(exp 7) cm(exp -2) s(exp -1), produce H II regions that are density bounded in the vertical direction (H II chimneys) allowing Lyc to escape the gaseous disk and penetrate into the Galactic halo. We provide analytic formulae for the Lyc escape fraction as functions of S(sub 0) O-star catalog of Garmany and a new Lyc stellar stellar Lyc stellar flux calibration, we find a production rate of Lyc photons by OB associations within 2.5 kpc of Psi(sub Lyc) = 3.3 x 10(exp 7) cm(exp -2) s(exp -1). Integrating the fraction of Lyc photons that escape the disk over our adopted luminosity function of OB associations, we estimate that approximately 7% of the ionizing photons, or Phi(sub Lyc) = 2.3 x 10(exp 6) cm(exp -2) s(exp -1), escape each side of the H I disk layer and penetrate the diffuse ionized medium ('Reynolds layer'). This flux is sufficient to explain the potoionization of this, although we have not constructed a model for the observed H-alpha emission and pulsar dispersion measures that is fully consistent with the absorption rate of Lyc in the H II layer. Since our quiescent model does not account for the effects of dynamic chimneys and superbubbles, which should enhance Lyc escape, we conclude the O stars are the probable source of ionizing radiation for the Reynolds layer. For a random distribution of OB associations throughout the disk, the Lyc flux is nearly uniform for heights Z is greater than approximately 0.8 kpc above the midplane.

  13. Association of plutonium with sediments from the Ob and Yenisey Rivers and Estuaries

    International Nuclear Information System (INIS)

    Skipperud, Lindis; Brown, Justin; Fifield, L. Keith; Oughton, Deborah H.; Salbu, Brit

    2009-01-01

    The present study applied sequential extraction techniques to investigate the binding and mobility of plutonium (Pu) in sediments from the rivers and estuaries of the Ob and Yenisey. As a study site, the Ob and Yenisey are particularly interesting as both rivers have weapons-grade Pu sources in their catchment areas, including the Russian Pu production and reprocessing plants at Mayak, Tomsk-7 and Krashnoyarsk, and the Semipalantinsk nuclear weapons testing site in Kazakhstan. Plutonium activity and 240 Pu/ 239 Pu ratios were determined using accelerator mass spectrometry (AMS). Sequential extractions showed that between 47 and 80% of the Pu in Yenisey River sediments and 35-53% of the Pu in soils around the Techa River are mobilized with weak oxidising agents, which can indicate that Pu is bound to organic material. In contrast, Pu in Ob and Yenisey Estuarine sediments was more strongly bound, with 60-100% being found in the HNO 3 -extractable fraction. This change in speciation could reflect either that Pu bound to organic material in the Techa and Yenisey River sediments becomes more fixed to the sediments with time, or that organic-bound Pu is mobilized and released to the water when the sediments encounter the more saline water of the Ob and Yenisey estuaries. In general, 240 Pu/ 239 Pu ratios were relatively consistent between different extraction fractions, although, in whole sediments, an increase in ratio was observed with distance from the source. This reflects the increased influence of weapon fallout from catchment runoff within the river systems, as compared to the weapons-grade sources close to the production and reprocessing plants. Knowledge of Pu speciation in the Ob and Yenisey Rivers, and the processes controlling its behaviour in estuarine systems, can improve predictions of its transfer and subsequent environmental impact to Arctic Seas

  14. ObsPy: A Python Toolbox for Seismology - Recent Developments and Applications

    Science.gov (United States)

    Megies, T.; Krischer, L.; Barsch, R.; Sales de Andrade, E.; Beyreuther, M.

    2014-12-01

    ObsPy (http://www.obspy.org) is a community-driven, open-source project dedicated to building a bridge for seismology into the scientific Python ecosystem. It offersa) read and write support for essentially all commonly used waveform, station, and event metadata file formats with a unified interface,b) a comprehensive signal processing toolbox tuned to the needs of seismologists,c) integrated access to all large data centers, web services and databases, andd) convenient wrappers to legacy codes like libtau and evalresp.Python, currently the most popular language for teaching introductory computer science courses at top-ranked U.S. departments, is a full-blown programming language with the flexibility of an interactive scripting language. Its extensive standard library and large variety of freely available high quality scientific modules cover most needs in developing scientific processing workflows. Together with packages like NumPy, SciPy, Matplotlib, IPython, Pandas, lxml, and PyQt, ObsPy enables the construction of complete workflows in Python. These vary from reading locally stored data or requesting data from one or more different data centers through to signal analysis and data processing and on to visualizations in GUI and web applications, output of modified/derived data and the creation of publication-quality figures.ObsPy enjoys a large world-wide rate of adoption in the community. Applications successfully using it include time-dependent and rotational seismology, big data processing, event relocations, and synthetic studies about attenuation kernels and full-waveform inversions to name a few examples. All functionality is extensively documented and the ObsPy tutorial and gallery give a good impression of the wide range of possible use cases.We will present the basic features of ObsPy, new developments and applications, and a roadmap for the near future and discuss the sustainability of our open-source development model.

  15. OBS Data Denoising Based on Compressed Sensing Using Fast Discrete Curvelet Transform

    Science.gov (United States)

    Nan, F.; Xu, Y.

    2017-12-01

    OBS (Ocean Bottom Seismometer) data denoising is an important step of OBS data processing and inversion. It is necessary to get clearer seismic phases for further velocity structure analysis. Traditional methods for OBS data denoising include band-pass filter, Wiener filter and deconvolution etc. (Liu, 2015). Most of these filtering methods are based on Fourier Transform (FT). Recently, the multi-scale transform methods such as wavelet transform (WT) and Curvelet transform (CvT) are widely used for data denoising in various applications. The FT, WT and CvT could represent signal sparsely and separate noise in transform domain. They could be used in different cases. Compared with Curvelet transform, the FT has Gibbs phenomenon and it cannot handle points discontinuities well. WT is well localized and multi scale, but it has poor orientation selectivity and could not handle curves discontinuities well. CvT is a multiscale directional transform that could represent curves with only a small number of coefficients. It provide an optimal sparse representation of objects with singularities along smooth curves, which is suitable for seismic data processing. As we know, different seismic phases in OBS data are showed as discontinuous curves in time domain. Hence, we promote to analysis the OBS data via CvT and separate the noise in CvT domain. In this paper, our sparsity-promoting inversion approach is restrained by L1 condition and we solve this L1 problem by using modified iteration thresholding. Results show that the proposed method could suppress the noise well and give sparse results in Curvelet domain. Figure 1 compares the Curvelet denoising method with Wavelet method on the same iterations and threshold through synthetic example. a)Original data. b) Add-noise data. c) Denoised data using CvT. d) Denoised data using WT. The CvT can well eliminate the noise and has better result than WT. Further we applied the CvT denoise method for the OBS data processing. Figure 2a

  16. XMM-NEWTON MONITORING OF THE CLOSE PRE-MAIN-SEQUENCE BINARY AK SCO. EVIDENCE OF TIDE-DRIVEN FILLING OF THE INNER GAP IN THE CIRCUMBINARY DISK

    Energy Technology Data Exchange (ETDEWEB)

    Gomez de Castro, Ana Ines [S. D. Astronomia y Geodesia and Instituto de Matematica Interdisciplinar, Fac. de CC Matematicas, Universidad Complutense, E-28040 Madrid (Spain); Lopez-Santiago, Javier [Departamento de Astrofisica, Fac de CC Fisicas, Universidad Complutense, E-28040 Madrid (Spain); Talavera, Antonio [European Space Astronomy Center, Villanueva de la Canada, E-28691, Madrid (Spain); Sytov, A. Yu.; Bisikalo, D. [Institute of Astronomy of the Russian Academy of Sciences, Pyatnitskaya St. 48, 109017 Moscow (Russian Federation)

    2013-03-20

    AK Sco stands out among pre-main-sequence binaries because of its prominent ultraviolet excess, the high eccentricity of its orbit, and the strong tides driven by it. AK Sco consists of two F5-type stars that get as close as 11 R{sub *} at periastron passage. The presence of a dense (n{sub e} {approx} 10{sup 11} cm{sup -3}) extended envelope has been unveiled recently. In this article, we report the results from an XMM-Newton-based monitoring of the system. We show that at periastron, X-ray and UV fluxes are enhanced by a factor of {approx}3 with respect to the apastron values. The X-ray radiation is produced in an optically thin plasma with T {approx} 6.4 Multiplication-Sign 10{sup 6} K and it is found that the N{sub H} column density rises from 0.35 Multiplication-Sign 10{sup 21} cm{sup -2} at periastron to 1.11 Multiplication-Sign 10{sup 21} cm{sup -2} at apastron, in good agreement with previous polarimetric observations. The UV emission detected in the Optical Monitor band seems to be caused by the reprocessing of the high-energy magnetospheric radiation on the circumstellar material. Further evidence of the strong magnetospheric disturbances is provided by the detection of line broadening of 278.7 km s{sup -1} in the N V line with Hubble Space Telescope/Space Telescope Imaging Spectrograph. Numerical simulations of the mass flow from the circumbinary disk to the components have been carried out. They provide a consistent scenario with which to interpret AK Sco observations. We show that the eccentric orbit acts like a gravitational piston. At apastron, matter is dragged efficiently from the inner disk border, filling the inner gap and producing accretion streams that end as ring-like structures around each component of the system. At periastron, the ring-like structures come into contact, leading to angular momentum loss, and thus producing an accretion outburst.

  17. Deposition of plutonium isotopes and Cs-137 in sediments of the Ob delta from the beginning of the nuclear age

    International Nuclear Information System (INIS)

    Panteleyev, G.P.; Livingston, H.D.; Sayles, F.L.; Medkova, O.N.

    1995-01-01

    As an approach to an assessment of the transport of artificial radionuclides through the Ob river system towards the arctic Ocean, results are presented from the analyses of a series of sediment cores collected in the Ob delta and estuary in 1994. These cores, collected in areas of sediment accumulation, contain the depositional history at the Ob mouth of substances associated with sediment particles from the whole river system watershed. Several approaches to dating these sediments permitted the development of a chronology for the deposition of plutonium isotopes and Cs-137, following their first introduction to the environment a half century ago. Some preliminary results for I-129 are also presented. 6 figs

  18. Multifunctional Bi2ZnOB2O6 single crystals for second and third order nonlinear optical applications

    International Nuclear Information System (INIS)

    Iliopoulos, K.; Kasprowicz, D.; Majchrowski, A.; Michalski, E.; Gindre, D.; Sahraoui, B.

    2013-01-01

    Bi 2 ZnOB 2 O 6 nonlinear optical single crystals were grown by means of the Kyropoulos method from stoichiometric melt. The second and third harmonic generation (SHG/THG) of Bi 2 ZnOB 2 O 6 crystals were investigated by the SHG/THG Maker fringes technique. Moreover, SHG microscopy studies were carried out providing two-dimensional SHG images as a function of the incident laser polarization. The high nonlinear optical efficiency combined with the possibility to grow high quality crystals make Bi 2 ZnOB 2 O 6 an excellent candidate for photonic applications

  19. Marked augmentation of PLGA nanoparticle-induced metabolically beneficial impact of γ-oryzanol on fuel dyshomeostasis in genetically obese-diabetic ob/ob mice.

    Science.gov (United States)

    Kozuka, Chisayo; Shimizu-Okabe, Chigusa; Takayama, Chitoshi; Nakano, Kaku; Morinaga, Hidetaka; Kinjo, Ayano; Fukuda, Kotaro; Kamei, Asuka; Yasuoka, Akihito; Kondo, Takashi; Abe, Keiko; Egashira, Kensuke; Masuzaki, Hiroaki

    2017-11-01

    Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derangement in high fat diet (HFD)-induced obese diabetic mice. However, extremely low absorption efficiency from intestine of γ-oryzanol is a tough obstacle for the clinical application. Therefore, in this study, to overcome extremely low bioavailability of γ-oryzanol with super-high lipophilicity, we encapsulated γ-oryzanol in polymer poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (Nano-Orz), and evaluated its metabolically beneficial impact in genetically obese-diabetic ob/ob mice, the best-known severest diabetic model in mice. To our surprise, Nano-Orz markedly ameliorated fuel metabolism with an unexpected magnitude (∼1000-fold lower dose) compared with regular γ-oryzanol. Furthermore, such a conspicuous impact was achievable by its administration once every 2 weeks. Besides the excellent impact on dysfunction of hypothalamus and pancreatic islets, Nano-Orz markedly decreased ER stress and inflammation in liver and adipose tissue. Collectively, nanotechnology-based developments of functional foods oriented toward γ-oryzanol shed light on the novel approach for the treatment of a variety of metabolic diseases in humans.

  20. Evaluation of Satellite-Based Upper Troposphere Cloud Top Height Retrievals in Multilayer Cloud Conditions During TC4

    Science.gov (United States)

    Chang, Fu-Lung; Minnis, Patrick; Ayers, J. Kirk; McGill, Matthew J.; Palikonda, Rabindra; Spangenberg, Douglas A.; Smith, William L., Jr.; Yost, Christopher R.

    2010-01-01

    Upper troposphere cloud top heights (CTHs), restricted to cloud top pressures (CTPs) less than 500 hPa, inferred using four satellite retrieval methods applied to Twelfth Geostationary Operational Environmental Satellite (GOES-12) data are evaluated using measurements during the July August 2007 Tropical Composition, Cloud and Climate Coupling Experiment (TC4). The four methods are the single-layer CO2-absorption technique (SCO2AT), a modified CO2-absorption technique (MCO2AT) developed for improving both single-layered and multilayered cloud retrievals, a standard version of the Visible Infrared Solar-infrared Split-window Technique (old VISST), and a new version of VISST (new VISST) recently developed to improve cloud property retrievals. They are evaluated by comparing with ER-2 aircraft-based Cloud Physics Lidar (CPL) data taken during 9 days having extensive upper troposphere cirrus, anvil, and convective clouds. Compared to the 89% coverage by upper tropospheric clouds detected by the CPL, the SCO2AT, MCO2AT, old VISST, and new VISST retrieved CTPs less than 500 hPa in 76, 76, 69, and 74% of the matched pixels, respectively. Most of the differences are due to subvisible and optically thin cirrus clouds occurring near the tropopause that were detected only by the CPL. The mean upper tropospheric CTHs for the 9 days are 14.2 (+/- 2.1) km from the CPL and 10.7 (+/- 2.1), 12.1 (+/- 1.6), 9.7 (+/- 2.9), and 11.4 (+/- 2.8) km from the SCO2AT, MCO2AT, old VISST, and new VISST, respectively. Compared to the CPL, the MCO2AT CTHs had the smallest mean biases for semitransparent high clouds in both single-layered and multilayered situations whereas the new VISST CTHs had the smallest mean biases when upper clouds were opaque and optically thick. The biases for all techniques increased with increasing numbers of cloud layers. The transparency of the upper layer clouds tends to increase with the numbers of cloud layers.

  1. Further RIOTS4 Characterization of Field OB Stars in the SMC

    Science.gov (United States)

    Oey, M. S.; Barnes, Jesse R.; Paggeot, Kevin J.; Dorigo Jones, John; Castro, Norberto; Simon-Diaz, Sergio; Kratter, Kaitlin M.; Moe, Maxwell; Szymanski, Michal

    2018-06-01

    We present recent results from the Runaways and O-Type Star Spectroscopic Survey of the SMC (RIOTS4), a survey quantifying properties of the field OB stars in the Small Magellanic Cloud (SMC). Based on PSF-fitting photometry and astrometry of OGLE-III I-band images, we quantify the degree of isolation for the target OB stars, classifying them as "tip-of-the-iceberg" stars accompanied by small, sparse, clusters; or as true, isolated field stars. Many of these field stars must be runaways, which we evaluate using GAIA DR2 proper motions. We measure v sin i using the IACOB code Fourier analysis, finding that the bimodal distribution of projected rotation velocities is less pronounced for O stars than early B stars. We examine rotation in relation to relative isolation and runaway status.

  2. BOREAS TF-3 Automated Chamber CO2 Flux Data from the NSA-OBS

    Science.gov (United States)

    Goulden, Michael L.; Crill, Patrick M.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem Atmosphere Study Tower Flux (BOREAS TF-3) and Trace Gas Biogeochemistry (TGB-1) teams collected automated CO2 chamber flux data in their efforts to fully describe the CO2 flux at the Northern Study Area-Old Black Spruce (NSA-OBS) site. This data set contains fluxes of CO2 at the NSA-OBS site measured using automated chambers. In addition to reporting the CO2 flux, it reports chamber air temperature, moss temperature, and light levels during each measurement. The data set covers the period from 23-Sep-1995 through 26-Oct-1995 and from 28-May-1996 through 21-Oct-1996. The data are stored in tabular ASCII files.

  3. Genetic diversity analysis among male and female Jojoba genotypes employing gene targeted molecular markers, start codon targeted (SCoT) polymorphism and CAAT box-derived polymorphism (CBDP) markers.

    Science.gov (United States)

    Heikrujam, Monika; Kumar, Jatin; Agrawal, Veena

    2015-09-01

    To detect genetic variations among different Simmondsia chinensis genotypes, two gene targeted markers, start codon targeted (SCoT) polymorphism and CAAT box-derived polymorphism (CBDP) were employed in terms of their informativeness and efficiency in analyzing genetic relationships among different genotypes. A total of 15 SCoT and 17 CBDP primers detected genetic polymorphism among 39 Jojoba genotypes (22 females and 17 males). Comparatively, CBDP markers proved to be more effective than SCoT markers in terms of percentage polymorphism as the former detecting an average of 53.4% and the latter as 49.4%. The Polymorphic information content (PIC) value and marker index (MI) of CBPD were 0.43 and 1.10, respectively which were higher than those of SCoT where the respective values of PIC and MI were 0.38 and 1.09. While comparing male and female genotype populations, the former showed higher variation in respect of polymorphic percentage and PIC, MI and Rp values over female populations. Nei's diversity (h) and Shannon index (I) were calculated for each genotype and found that the genotype "MS F" (in both markers) was highly diverse and genotypes "Q104 F" (SCoT) and "82-18 F" (CBDP) were least diverse among the female genotype populations. Among male genotypes, "32 M" (CBDP) and "MS M" (SCoT) revealed highest h and I values while "58-5 M" (both markers) was the least diverse. Jaccard's similarity co-efficient of SCoT markers ranged from 0.733 to 0.922 in female genotypes and 0.941 to 0.746 in male genotype population. Likewise, CBDP data analysis also revealed similarity ranging from 0.751 to 0.958 within female genotypes and 0.754 to 0.976 within male genotype populations thereby, indicating genetically diverse Jojoba population. Employing the NTSYS (Numerical taxonomy and multivariate analysis system) Version 2.1 software, both the markers generated dendrograms which revealed that all the Jojoba genotypes were clustered into two major groups, one group consisting of

  4. Conversion of chlorinated propanes by Methylosinus trichosporium OB3b expressing soluble methane monooxygenase

    OpenAIRE

    Bosma, T.; Janssen, D.B.

    1998-01-01

    Chlorinated propanes are important pollutants that may show persistent behaviour in the environment. The biotransformation of 1-chloropropane, 1,2-dichloropropane, 1,3-dichloropropane and 1,2,3-trichloropropane was studied using resting cell suspensions of Methylosinus trichosporium OB3b expressing soluble methane monooxygenase. The transformation followed first-order kinetics. The rate constants were in the order 1-chloropropane > 1,3-dichloropropane > 1,2-dichloropropane > 1,2,3-trichloropr...

  5. ObStruct: a method to objectively analyse factors driving population structure using Bayesian ancestry profiles.

    Directory of Open Access Journals (Sweden)

    Velimir Gayevskiy

    Full Text Available Bayesian inference methods are extensively used to detect the presence of population structure given genetic data. The primary output of software implementing these methods are ancestry profiles of sampled individuals. While these profiles robustly partition the data into subgroups, currently there is no objective method to determine whether the fixed factor of interest (e.g. geographic origin correlates with inferred subgroups or not, and if so, which populations are driving this correlation. We present ObStruct, a novel tool to objectively analyse the nature of structure revealed in Bayesian ancestry profiles using established statistical methods. ObStruct evaluates the extent of structural similarity between sampled and inferred populations, tests the significance of population differentiation, provides information on the contribution of sampled and inferred populations to the observed structure and crucially determines whether the predetermined factor of interest correlates with inferred population structure. Analyses of simulated and experimental data highlight ObStruct's ability to objectively assess the nature of structure in populations. We show the method is capable of capturing an increase in the level of structure with increasing time since divergence between simulated populations. Further, we applied the method to a highly structured dataset of 1,484 humans from seven continents and a less structured dataset of 179 Saccharomyces cerevisiae from three regions in New Zealand. Our results show that ObStruct provides an objective metric to classify the degree, drivers and significance of inferred structure, as well as providing novel insights into the relationships between sampled populations, and adds a final step to the pipeline for population structure analyses.

  6. Obésité abdominale et autres biomarqueurs de risque ...

    African Journals Online (AJOL)

    Obésité abdominale et autres biomarqueurs de risque cardiométabolique: influence du niveau socioéconomique et du mode de vie dans deux populations noires apparentées, Cotonou (Bénin) et Port-au-Prince (Haïti). Asma EL Mabchour, Hélène Delisle, Colette Vilgrain, Phillipe Larco, Roger Sodjinou ...

  7. Bioinformatics analysis identify novel OB fold protein coding genes in C. elegans.

    Directory of Open Access Journals (Sweden)

    Daryanaz Dargahi

    Full Text Available BACKGROUND: The C. elegans genome has been extensively annotated by the WormBase consortium that uses state of the art bioinformatics pipelines, functional genomics and manual curation approaches. As a result, the identification of novel genes in silico in this model organism is becoming more challenging requiring new approaches. The Oligonucleotide-oligosaccharide binding (OB fold is a highly divergent protein family, in which protein sequences, in spite of having the same fold, share very little sequence identity (5-25%. Therefore, evidence from sequence-based annotation may not be sufficient to identify all the members of this family. In C. elegans, the number of OB-fold proteins reported is remarkably low (n=46 compared to other evolutionary-related eukaryotes, such as yeast S. cerevisiae (n=344 or fruit fly D. melanogaster (n=84. Gene loss during evolution or differences in the level of annotation for this protein family, may explain these discrepancies. METHODOLOGY/PRINCIPAL FINDINGS: This study examines the possibility that novel OB-fold coding genes exist in the worm. We developed a bioinformatics approach that uses the most sensitive sequence-sequence, sequence-profile and profile-profile similarity search methods followed by 3D-structure prediction as a filtering step to eliminate false positive candidate sequences. We have predicted 18 coding genes containing the OB-fold that have remarkably partially been characterized in C. elegans. CONCLUSIONS/SIGNIFICANCE: This study raises the possibility that the annotation of highly divergent protein fold families can be improved in C. elegans. Similar strategies could be implemented for large scale analysis by the WormBase consortium when novel versions of the genome sequence of C. elegans, or other evolutionary related species are being released. This approach is of general interest to the scientific community since it can be used to annotate any genome.

  8. Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown

    International Nuclear Information System (INIS)

    Catalioto, R.M.; Ailhaud, G.; Negrel, R.

    1990-01-01

    Growth Hormone has recently been shown to stimulate the formation of diacylglycerol in Ob1771 mouse preadipocyte cells without increasing inositol lipid turnover. Addition of growth hormone to Ob1771 cells prelabelled with [ 3 H]glycerol or [ 3 H]choline led to a rapid, transient and stoechiometric formation of labelled diacylglycerol and phosphocholine, respectively. In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in [ 3 H]ethanolamine prelabelled cells exposed to growth hormone was hardly detectable. Stimulation by growth hormone of cells prelabelled with (2-palmitoyl 9, 10 [ 3 H])phosphatidylcholine also induced the production of labelled diacyglycerol. Pertussis toxin abolished both diacylglycerol and phosphocholine formation induced by growth hormone. It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein

  9. Relative Stabilities of Conserved and Non-Conserved Structures in the OB-Fold Superfamily

    Directory of Open Access Journals (Sweden)

    Andrei T. Alexandrescu

    2009-05-01

    Full Text Available The OB-fold is a diverse structure superfamily based on a β-barrel motif that is often supplemented with additional non-conserved secondary structures. Previous deletion mutagenesis and NMR hydrogen exchange studies of three OB-fold proteins showed that the structural stabilities of sites within the conserved β-barrels were larger than sites in non-conserved segments. In this work we examined a database of 80 representative domain structures currently classified as OB-folds, to establish the basis of this effect. Residue-specific values were obtained for the number of Cα-Cα distance contacts, sequence hydrophobicities, crystallographic B-factors, and theoretical B-factors calculated from a Gaussian Network Model. All four parameters point to a larger average flexibility for the non-conserved structures compared to the conserved β-barrels. The theoretical B-factors and contact densities show the highest sensitivity.Our results suggest a model of protein structure evolution in which novel structural features develop at the periphery of conserved motifs. Core residues are more resistant to structural changes during evolution since their substitution would disrupt a larger number of interactions. Similar factors are likely to account for the differences in stability to unfolding between conserved and non-conserved structures.

  10. Improvements to the gridding of precipitation data across Europe under the E-OBS scheme

    Science.gov (United States)

    Cornes, Richard; van den Besselaar, Else; Jones, Phil; van der Schrier, Gerard; Verver, Ge

    2016-04-01

    Gridded precipitation data are a valuable resource for analyzing past variations and trends in the hydroclimate. Such data also provide a reference against which model simulations may be driven, compared and/or adjusted. The E-OBS precipitation dataset is widely used for such analyses across Europe, and is particularly valuable since it provides a spatially complete, daily field across the European domain. In this analysis, improvements to the E-OBS precipitation dataset will be presented that aim to provide a more reliable estimate of grid-box precipitation values, particularly in mountainous areas and in regions with a relative sparsity of input station data. The established three-stage E-OBS gridding scheme is retained, whereby monthly precipitation totals are gridded using a thin-plate spline; daily anomalies are gridded using indicator kriging; and the final dataset is produced by multiplying the two grids. The current analysis focuses on improving the monthly thin-plate spline, which has overall control on the final daily dataset. The results from different techniques are compared and the influence on the final daily data is assessed by comparing the data against gridded country-wide datasets produced by various National Meteorological Services

  11. An unidentified TeV source in the vicinity of Cygnus OB2

    Science.gov (United States)

    Aharonian, F.; Akhperjanian, A.; Beilicke, M.; Bernlöhr, K.; Börst, H.; Bojahr, H.; Bolz, O.; Coarasa, T.; Contreras, J.; Cortina, J.; Denninghoff, S.; Fonseca, V.; Girma, M.; Götting, N.; Heinzelmann, G.; Hermann, G.; Heusler, A.; Hofmann, W.; Horns, D.; Jung, I.; Kankanyan, R.; Kestel, M.; Kettler, J.; Kohnle, A.; Konopelko, A.; Kornmeyer, H.; Kranich, D.; Krawczynski, H.; Lampeitl, H.; Lopez, M.; Lorenz, E.; Lucarelli, F.; Magnussen, N.; Mang, O.; Meyer, H.; Milite, M.; Mirzoyan, R.; Moralejo, A.; Ona, E.; Panter, M.; Plyasheshnikov, A.; Prahl, J.; Pühlhofer, G.; Rauterberg, G.; Reyes, R.; Rhode, W.; Ripken, J.; Röhring, A.; Rowell, G. P.; Sahakian, V.; Samorski, M.; Schilling, M.; Schröder, F.; Siems, M.; Sobzynska, D.; Stamm, W.; Tluczykont, M.; Völk, H. J.; Wiedner, C. A.; Wittek, W.; Uchiyama, Y.; Takahashi, T.; HEGRA Collaboration

    2002-10-01

    Deep observation ( ~ 113 hrs) of the Cygnus region at TeV energies using the HEGRA stereoscopic system of air Čerenkov telescopes has serendipitously revealed a signal positionally inside the core of the OB association Cygnus OB2, at the edge of the 95% error circle of the EGRET source 3EG J2033+4118, and ~ 0.5o north of Cyg X-3. The source centre of gravity is RA alphaJ2000: 20h 32m 07s+/- 9.2sstat +/-2.2ssys, Dec deltaJ2000: +41o 30' 30''+/- 2.0'stat +/- 0.4'sys. The source is steady, has a post-trial significance of +4.6sigma , indication for extension with radius 5.6' at the ~ 3sigma level, and has a differential power-law flux with hard photon index of -1.9 +/-0.3stat +/-0.3sys. The integral flux above 1 TeV amounts ~ 3% that of the Crab. No counterpart for the TeV source at other wavelengths is presently identified, and its extension would disfavour an exclusive pulsar or AGN origin. If associated with Cygnus OB2, this dense concentration of young, massive stars provides an environment conducive to multi-TeV particle acceleration and likely subsequent interaction with a nearby gas cloud. Alternatively, one could envisage gamma -ray production via a jet-driven termination shock.

  12. A model for the infrared emission from an OB star cluster environment

    International Nuclear Information System (INIS)

    Leisawitz, D.

    1990-01-01

    Researchers developed an interactive radiative transfer code that predicts the infrared emission from an HII region containing diffuse ionized and atomic gas and dense molecular clouds. This model complements the investigation of the redistribution of OB star luminosity in the interstellar medium (Leisawitz and Hauser 1988, Ap. J., 332, 954). The model can be used as a diagnostic tool to probe the radiation field and matter density in an HII region, place constraints on the proximity and orientation of an illuminated molecular cloud with respect to the ionizing stars, test for the presence of small, transiently heated dust grains, and determine whether the dust-to-gas ratio is normal. Predictions of the model agree qualitatively and quantitatively with observations of blister-type HII regions ionized by well-studied OB clusters in which the distribution of dense neutral material is known. This is illustrated by a model for Infrared Astronomy Satellite (IRAS) observations of the region around NGC 7380 (S142). Researchers plan to use the model in a survey of regions of massive star formation in the outer Galaxy to study OB stars embedded to various degrees in their parental molecular clouds

  13. ObsPy – What can it do for data centers and observatories?

    Directory of Open Access Journals (Sweden)

    Joachim Wassermann

    2011-04-01

    Full Text Available Data acquisition by seismic centers relies on real-time systems, like SeisComP3, Antelope and Earthworm. However, these are complex systems that are designed for fast and precisely defined standard real-time analyses. Therefore, it is not a simple task to access or modify internal routines, and to integrate them into custom-processing workflows or to perform in-depth data analyses. Often a library is necessary that provides convenient access to data and allows easy control over all of the operations that are to be performed on the data. ObsPy is such a library, which is designed to access and process seismological waveform data and metadata. We use short and simple examples here to demonstrate how effective it is to use Python for seismological data analysis. Then, we illustrate the general capabilities of ObsPy, and highlight some of its specific aspects that are relevant for seismological data centers and observatories, through presentation of real-world examples. Finally, we demonstrate how the ObsPy library can be used to develop custom graphical user interface applications.

  14. Diacylglycerol production induced by growth hormone in Ob1771 preadipocytes arises from phosphatidylcholine breakdown

    Energy Technology Data Exchange (ETDEWEB)

    Catalioto, R.M.; Ailhaud, G.; Negrel, R. (Universite de Nice-Sophia Antipolis (France))

    1990-12-31

    Growth Hormone has recently been shown to stimulate the formation of diacylglycerol in Ob1771 mouse preadipocyte cells without increasing inositol lipid turnover. Addition of growth hormone to Ob1771 cells prelabelled with ({sup 3}H)glycerol or ({sup 3}H)choline led to a rapid, transient and stoechiometric formation of labelled diacylglycerol and phosphocholine, respectively. In contrast, no change was observed in the level of choline and phosphatidic acid whereas the release of water-soluble metabolites in ({sup 3}H)ethanolamine prelabelled cells exposed to growth hormone was hardly detectable. Stimulation by growth hormone of cells prelabelled with (2-palmitoyl 9, 10 ({sup 3}H))phosphatidylcholine also induced the production of labelled diacyglycerol. Pertussis toxin abolished both diacylglycerol and phosphocholine formation induced by growth hormone. It is concluded that growth hormone mediates diacylglycerol production in Ob1771 cells by means of phosphatidylcholine breakdown involving a phospholipase C which is likely coupled to the growth hormone receptor via a pertussis toxin-sensitive G-protein.

  15. New results from Ooty EAS array for cosmic sources at PeV energies: Cygnus X-3, Crab pulsar and Sco X-1

    International Nuclear Information System (INIS)

    Tonwar, S.C.; Gupta, S.K.; Gopalakrishnan, N.V.; Rajeev, M.R.; Srivatsan, R.; Sreekantan, B.V.

    1990-01-01

    Ooty group has reported detection of a steady signal from Cyg X-3 based on observations made during 1984-86 through detection of a directional excess. Further analysis of data has revealed a significant flux enhancement during April 1986, confirming observations reported by the CYGNUS group at Los Alamos and the Baksan group. These results show conclusively that the flux from Cyg X-3 is variable over a time scale of few weeks. We also report here the details of an unusual burst from Cyg X-3, consisting of 5 showers in 13 minutes, on June 19, 1985, which shows the variability of the flux from Cyg X-3 on a much shorter time scale of few minutes. Our analysis of showers arriving from the direction of the Crab pulsar has shown only a small time-averaged excess. But these data, when folded with the Crab pulsar period, show a very significant excess at the expected phase of the optical interpulse. This is the first detection of 33 ms pulsation in the PeV energy flux from the Crab pulsar. The exact alignment of the phase of emission over nearly 20 decades of energy, from meter wavelengths to PeV, makes the Crab pulsar a really unique source to study and understand details of mechanisms for emission and acceleration of particles in compact sources. We also present here a discussion of our observations on another X-ray binary, Sco X-1. Ooty data show a very significant excess in the number of showers from the direction of Sco X-1 during a two month period in 1986, in agreement with observations reported by the Mt. Chacaltaya group. These observations establish this X-ray binary as another important source of PeV energy radiation. (orig.)

  16. A M2FS Spectroscopic Study of Low-mass Young Stars in Orion OB1

    Science.gov (United States)

    Kaleida, Catherine C.; Briceno, Cesar; Calvet, Nuria; Mateo, Mario L.; Hernandez, Jesus

    2015-01-01

    Surveys of pre-main sequence stars in the ~4-10 Myr range provide a window into the decline of the accretion phase of stars and the formation of planets. Nearby star clusters and stellar associations allow for the study of these young stellar populations all the way down to the lowest mass members. One of the best examples of nearby 4-10 Myr old stellar populations is the Orion OB1 association. The CIDA Variability Survey of Orion OB1 (CVSO - Briceño et al. 2001) has used the variability properties of low-mass pre-main-sequence (PMS) stars to identify hundreds of K and M-type stellar members of the Orion OB1 association, a number of them displaying IR-excess emission and thought to be representative of more evolved disk-bearing young stars. Characterizing these young, low-mass objects using spectroscopy is integral to understanding the accretion phase in young stars. We present preliminary results of a spectroscopic survey of candidate and confirmed Orion OB1 low-mass members taken during November 2014 and February 2014 using the Michigan/Magellan Fiber Spectrograph (M2FS), a PI instrument on the Magellan Clay Telescope (PI: M. Matteo). Target fields located in the off-cloud regions of Orion were identified in the CVSO, and observed using the low and high-resolution modes of M2FS. Both low and high-resolution spectra are needed in order to confirm membership and derive masses, ages, kinematics and accretion properties. Initial analysis of these spectra reveal many new K and M-type members of the Orion OB1 association in these low extinction, off-cloud areas. These are the more evolved siblings of the youngest stars still embedded in the molecular clouds, like those in the Orion Nebula Cluster. With membership and spectroscopic indicators of accretion we are building the most comprehensive stellar census of this association, enabling us to derive a robust estimate of the fraction of young stars still accreting at a various ages, a key constraint for the end of

  17. VizieR Online Data Catalog: Properties of OB associations in IC 1613 (Garcia+, 2010)

    Science.gov (United States)

    Garcia, M.; Herrero, A.; Castro, N.; Corral, L.; Rosenberg, A.

    2014-06-01

    To understand the structure and evolution of massive stars, systematic surveys of the Local Group galaxies have been undertaken, to find these objects in environments of different chemical abundances. We focus on the metal-poor irregular galaxy IC 1613 to analyze the stellar and wind structure of its low-metallicity massive stars. We ultimately aim to study the metallicity-dependent driving mechanism of the winds of blue massive stars and use metal-poor massive stars of the Local Volume as a proxy for the stars in the early Universe. In a previous paper we produced a list of OB associations in IC 1613. Their properties are not only a powerful aid towards finding the most interesting candidate massive stars, but also reveal the structure and recent star formation history of the galaxy. We characterize these OB associations and study their connection with the galactic global properties. The reddening-free Q parameter is a powerful tool in the photometric analysis of young populations of massive stars, since it exhibits a smaller degree of degeneracy with OB spectral types than the B-V color. The color-magnitude diagram (Q vs. V) of the OB associations in IC 1613 is studied to determine their age and mass, and confirm the population of young massive stars. We identified more than 10 stars with M>=50M⊙. Spectral classification available for some of them confirm their massive nature, yet we find the common discrepancy with the spectroscopically derived masses. There is a general increasing trend of the mass of the most massive member with the number of members of each association, but not with the stellar density. The average diameter of the associations of this catalog is 40pc, half the historically considered typical size of OB associations. Size increases with the association population. The distribution of the groups strongly correlates with that of neutral and ionized hydrogen. We find the largest dispersion of association ages in the bubble region of the galaxy

  18. IPV Screening and Readiness to Respond to IPV in Ob-Gyn Settings: A Patient-Physician Study

    Directory of Open Access Journals (Sweden)

    Katherine M. Jones

    2018-01-01

    Full Text Available Purpose. Intimate partner violence (IPV is a serious, preventable public health concern that largely affects women of reproductive age. Obstetrician-gynecologists (ob-gyns have a unique opportunity to identify and support women experiencing IPV to improve women’s health. Considering recent efforts to increase IPV awareness and intervention, the present study aimed to provide a current evaluation of nationally representative samples to assess ob-gyn readiness to respond to IPV as well as patient IPV-related experiences. Methods. 400 ob-gyns were randomly selected from American College of Obstetricians and Gynecologists’ (ACOG Collaborative Ambulatory Research Network. Each physician was mailed one physician survey and 25 patient surveys. Results. IPV training/education and IPV screening practices were associated with most measures of ob-gyn readiness to respond to IPV. Among respondents, 36.8% endorsed screening all patients at annual exams; however, 36.8% felt they did not have sufficient training to assist individuals in addressing IPV. Workplace encouragement of IPV response was associated with training, screening, detection, preparation/knowledge, response practices, and resources. Thirty-one percent of patients indicated their ob-gyn had asked about possible IPV experiences during their medical visit. Conclusion. Findings highlight specific gaps in ob-gyns’ IPV knowledge and response practices to be further addressed by IPV training.

  19. Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob)

    Science.gov (United States)

    Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Schäfer, Bárbara Tavares; Silveira, Mariana Póvoa; Castelucci, Patricia

    2014-01-01

    AIM: To investigate the colocalization, density and profile of neuronal areas of enteric neurons in the ileum of male obese mice. METHODS: The small intestinal samples of male mice in an obese group (OG) (C57BL/6J ob/ob) and a control group (CG) (+/+) were used. The tissues were analyzed using a double immunostaining technique for immunoreactivity (ir) of the P2X2 receptor, nitric oxide synthase (NOS), choline acetyl transferase (ChAT) and calretinin (Calr). Also, we investigated the density and profile of neuronal areas of the NOS-, ChAT- and Calr-ir neurons in the myenteric plexus. Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method. RESULTS: The analysis demonstrated that the P2X2 receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG. Neuronal density values (neuron/cm2) decreased 31% (CG: 6579 ± 837; OG: 4556 ± 407) and 16.5% (CG: 7796 ± 528; OG: 6513 ± 610) in the NOS-ir and calretinin-ir neurons in the OG, respectively (P < 0.05). Density of ChAT-ir (CG: 6200 ± 310; OG: 8125 ± 749) neurons significantly increased 31% in the OG (P < 0.05). Neuron size studies demonstrated that NOS, ChAT, and Calr-ir neurons did not differ significantly between the CG and OG groups. The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG. CONCLUSION: Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir, ChAT-ir and CalR-ir myenteric neurons. PMID:25320527

  20. Upper Gastrointestinal (GI) Series

    Science.gov (United States)

    ... standard barium upper GI series, which uses only barium a double-contrast upper GI series, which uses both air and ... evenly coat your upper GI tract with the barium. If you are having a double-contrast study, you will swallow gas-forming crystals that ...

  1. MUG-OBS - Multiparameter Geophysical Ocean Bottom System : a new instrumental approach to monitor earthquakes.

    Science.gov (United States)

    hello, yann; Charvis, Philippe; Yegikyan, Manuk; verfaillie, Romain; Rivet, Diane

    2016-04-01

    Real time monitoring of seismic activity is a major issue for early warning of earthquakes and tsunamis. It can be done using regional scale wired nodes, such as Neptune in Canada and in the U.S, or DONET in Japan. Another approach to monitor seismic activity at sea is to deploying repeatedly OBS array like during the amphibious Cascadia Initiative (four time 1-year deployments), the Japanese Pacific Array (broadband OBSs "ocean-bottom broadband dispersion survey" with 2-years autonomy), the Obsismer program in the French Lesser Antilles (eight time 6-months deployments) and the Osisec program in Ecuador (four time 6-months deployments). These autonomous OBSs are self-recovered or recovered using an ROV. These systems are costly including ship time, and require to recover the OBS before to start working on data. Among the most recent alternative we developed a 3/4 years autonomy ocean bottom system with 9 channels (?) allowing the acquisition of different seismic or environmental parameters. MUG-OBS is a free falling instrument rated down to 6000 m. The installation of the sensor is monitored by acoustic commands from the surface and a health bulletin with data checking is recovered by acoustic during the installation. The major innovation is that it is possible to recover the data any time on demand (regularly every 6-months or after a crisis) using one of the 6 data-shuttles released from the surface by acoustic command using a one day fast cruise boat of opportunity. Since sensors stayed at the same location for 3 years, it is a perfect tool to monitor large seismic events, background seismic activity and aftershock distribution. Clock, drift measurement and GPS localization is automatic when the shuttle reaches the surface. For remote areas, shuttles released automatically and a seismic events bulletin is transmitted. Selected data can be recovered by two-way Iridium satellite communication. After a period of 3 years the main station is self-recovered by

  2. Not all stars form in clusters - measuring the kinematics of OB associations with Gaia

    Science.gov (United States)

    Ward, Jacob L.; Kruijssen, J. M. Diederik

    2018-04-01

    It is often stated that star clusters are the fundamental units of star formation and that most (if not all) stars form in dense stellar clusters. In this monolithic formation scenario, low-density OB associations are formed from the expansion of gravitationally bound clusters following gas expulsion due to stellar feedback. N-body simulations of this process show that OB associations formed this way retain signs of expansion and elevated radial anisotropy over tens of Myr. However, recent theoretical and observational studies suggest that star formation is a hierarchical process, following the fractal nature of natal molecular clouds and allowing the formation of large-scale associations in situ. We distinguish between these two scenarios by characterizing the kinematics of OB associations using the Tycho-Gaia Astrometric Solution catalogue. To this end, we quantify four key kinematic diagnostics: the number ratio of stars with positive radial velocities to those with negative radial velocities, the median radial velocity, the median radial velocity normalized by the tangential velocity, and the radial anisotropy parameter. Each quantity presents a useful diagnostic of whether the association was more compact in the past. We compare these diagnostics to models representing random motion and the expanding products of monolithic cluster formation. None of these diagnostics show evidence of expansion, either from a single cluster or multiple clusters, and the observed kinematics are better represented by a random velocity distribution. This result favours the hierarchical star formation model in which a minority of stars forms in bound clusters and large-scale, hierarchically structured associations are formed in situ.

  3. WNIN/GR-Ob - an insulin-resistant obese rat model from inbred WNIN strain.

    Science.gov (United States)

    Harishankar, N; Vajreswari, A; Giridharan, N V

    2011-09-01

    WNIN/GR-Ob is a mutant obese rat strain with impaired glucose tolerance (IGT) developed at the National Institute of Nutrition (NIN), Hyderabad, India, from the existing 80 year old Wistar rat (WNIN) stock colony. The data presented here pertain to its obese nature along with IGT trait as evidenced by physical, physiological and biochemical parameters. The study also explains its existence, in three phenotypes: homozygous lean (+/+), heterozygous carrier (+/-) and homozygous obese (-/-). Thirty animals (15 males and 15 females) from each phenotype (+/+, +/-, -/-) and 24 lean and obese (6 males and 6 females) rats were taken for growth and food intake studies respectively. Twelve adult rats from each phenotype were taken for body composition measurement by total body electrical conductivity (TOBEC); 12 rats of both genders from each phenotype at different ages were taken for clinical chemistry parameters. Physiological indices of insulin resistance were calculated according to the homeostasis model assessment for insulin resistance (HOMA-IR) and also by studying U¹⁴C 2-deoxy glucose uptake (2DG). WNINGR-Ob mutants had high growth, hyperphagia, polydipsia, polyurea, glycosuria, and significantly lower lean body mass, higher fat mass as compared with carrier and lean rats. These mutants, at 50 days of age displayed abnormal response to glucose load (IGT), hyperinsulinaemia, hypertriglyceridaemia, hypercholesterolaemia and hyperleptinaemia. Basal and insulin-stimulated glucose uptakes by diaphragm were significantly decreased in obese rats as compared with lean rats. Obese rats of the designated WNIN/GR-Ob strain showed obesity with IGT, as adjudged by physical, physiological and biochemical indices. These indices varied among the three phenotypes, being lowest in lean, highest in obese and intermediate in carrier phenotypes thereby suggesting that obesity is inherited as autosomal incomplete dominant trait in this strain. This mutant obese rat model is easy to

  4. Development of the TeamOBS-PPH - targeting clinical performance in postpartum hemorrhage.

    Science.gov (United States)

    Brogaard, Lise; Hvidman, Lone; Hinshaw, Kim; Kierkegaard, Ole; Manser, Tanja; Musaeus, Peter; Arafeh, Julie; Daniels, Kay I; Judy, Amy E; Uldbjerg, Niels

    2018-06-01

    This study aimed to develop a valid and reliable TeamOBS-PPH tool for assessing clinical performance in the management of postpartum hemorrhage (PPH). The tool was evaluated using video-recordings of teams managing PPH in both real-life and simulated settings. A Delphi panel consisting of 12 obstetricians from the UK, Norway, Sweden, Iceland, and Denmark achieved consensus on (i) the elements to include in the assessment tool, (ii) the weighting of each element, and (iii) the final tool. The validity and reliability were evaluated according to Cook and Beckman. (Level 1) Four raters scored four video-recordings of in situ simulations of PPH. (Level 2) Two raters scored 85 video-recordings of real-life teams managing patients with PPH ≥1000 mL in two Danish hospitals. (Level 3) Two raters scored 15 video-recordings of in situ simulations of PPH from a US hospital. The tool was designed with scores from 0 to 100. (Level 1) Teams of novices had a median score of 54 (95% CI 48-60), whereas experienced teams had a median score of 75 (95% CI 71-79; p < 0.001). (Level 2) The intra-rater [intra-class correlation (ICC) = 0.96] and inter-rater (ICC = 0.83) agreements for real-life PPH were strong. The tool was applicable in all cases: atony, retained placenta, and lacerations. (Level 3) The tool was easily adapted to in situ simulation settings in the USA (ICC = 0.86). The TeamOBS-PPH tool appears to be valid and reliable for assessing clinical performance in real-life and simulated settings. The tool will be shared as the free TeamOBS App. © 2018 Nordic Federation of Societies of Obstetrics and Gynecology.

  5. A Multi-Fiber Spectroscopic Search for Low-mass Young Stars in Orion OB1

    Science.gov (United States)

    Loerincs, Jacqueline; Briceno, Cesar; Calvet, Nuria; Mateo, Mario L.; Hernandez, Jesus

    2017-01-01

    We present here results of a low resolution spectroscopic followup of candidate low-mass pre-main sequence stars in the Orion OB1 association. Our targets were selected from the CIDA Variability Survey of Orion (CVSO), and we used the Michigan/Magellan Fiber Spectrograph (M2FS) on the Magellan Clay 6.5m telescope to obtain spectra of 500 candidate T Tauri stars distributed in seven 0.5 deg diameter fields, adding to a total area of ~5.5 deg2. We identify young stars by looking at the distinctive Hα 6563 Å emission and Lithium Li I 6707 Å absorption features characteristic of young low mass pre-main sequence stars. Furthermore, by measuring the strength of their Hα emission lines, confirmed T Tauri stars can be classified as either Classical T Tauris (CTTS) or Weak-line T Tauris (WTTS), which give indication of whether the star is actively accreting material from a gas and dust disk surrounding the star, which may be the precursor of a planetary system. We confirm a total of 90 T Tauri stars, of which 50% are newly identified young members of Orion; out of the 49 new detections,15 are accreting CTTS, and of these all but one are found in the OB1b sub-region. This result is in line with our previous findings that this region is much younger than the more extended Orion OB1a sub-association. The M2FS results add to our growing census of young stars in Orion, that is allowing us to characterize in a systematic and consistent way the distribution of stellar ages across the entire complex, in order to building a complete picture of star formation in this, one of nearest most active sites of star birth.

  6. Nature vs. Nurture: The influence of OB star environments on proto-planetary disk evolution

    Science.gov (United States)

    Bouwman, Jeroen

    2006-09-01

    We propose a combined IRAC/IRS study of a large, well-defined and unbiased X-ray selected sample of pre-main-sequence stars in three OB associations: Pismis 24 in NGC 6357, NGC 2244 in the Rosette Nebula, and IC 1795 in the W3 complex. The samples are based on recent Chandra X-ray Observatory studies which reliably identify hundreds of cluster members and were carefully chosen to avoid high infrared nebular background. A new Chandra exposure of IC 1795 is requested, and an optical followup to characterise the host stars is planned.

  7. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    OpenAIRE

    Sarai S. Mendoza-Retana; Miguel A. Gallegos-Robles; Uriel González-Salas; José L. García-Hernández; Manuel Fortis-Hernández; Cirilo Vázquez-Vázquez; Héctor I. Trejo-Escareño

    2017-01-01

    La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante ...

  8. Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family.

    Science.gov (United States)

    Krapp, S; Kelly, G; Reischl, J; Weinzierl, R O; Matthews, S

    1998-02-01

    RNA polymerase II subunit RPB8 is an essential subunit that is highly conserved throughout eukaryotic evolution and is present in all three types of nuclear RNA polymerases. We report the first high resolution structural insight into eukaryotic RNA polymerase architecture with the solution structure of RPB8 from Saccharomyces cerevisiae. It consists of an eight stranded, antiparallel beta-barrel, four short helical regions and a large, unstructured omega-loop. The strands are connected in classic Greek-key fashion. The overall topology is unusual and contains a striking C2 rotational symmetry. Furthermore, it is most likely a novel associate of the oligonucleotide/oligosaccharide (OB) binding protein class.

  9. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    Science.gov (United States)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  10. Adipose cell differentiation: evidence for a two-step process in the polyamine-dependent Ob1754 clonal line.

    Science.gov (United States)

    Amri, E Z; Dani, C; Doglio, A; Etienne, J; Grimaldi, P; Ailhaud, G

    1986-01-01

    A subclone of preadipocyte Ob17 cells has been isolated (Ob1754 clonal line). Confluent Ob1754 cells treated with an inhibitor of spermidine and spermine synthesis, methylglyoxal bis(guanylhydrazone), were totally dependent upon putrescine addition for the expression of glycerol-3-phosphate dehydrogenase which behaved as a late marker of adipose conversion. Under these conditions, the early expression of lipoprotein lipase during growth arrest remained unchanged. Studies at the mRNA level showed that the expression of unidentified pOb24 and pGH3 mRNAs, which was parallel to that of lipoprotein lipase, is independent of polyamine addition whereas the late emergence of glycerol-3-phosphate dehydrogenase mRNA was putrescine-dependent and co-ordinated with the expression of pAL422 mRNA encoding for a myelin-P2 homologue [Bernlohr, Angus, Lane, Bolanowski & Kelly (1984) Proc. Natl. Acad. Sci. U.S.A. 81, 5468-5472]. The appearance of lipoprotein lipase preceded DNA synthesis and post-confluent mitoses which were both putrescine-dependent and which took place before the appearance of glycerol-3-phosphate dehydrogenase. Thus the adipose conversion of Ob1754 cells involves the expression of at least two separate sets of markers which are differently regulated. Images Fig. 3. Fig. 6. PMID:3800927

  11. Effects of coronal regions on the x-ray flux and ionization conditions in the winds of ob supergiants and of stars

    International Nuclear Information System (INIS)

    Cassinelli, J.P.; Olson, G.L.

    1979-01-01

    The anomalously strong O VI and N V lines in O stars and the C IV lines in B supergiants may be due to Auger ionization by X-rays from a thin coronal zone at the base of the cool stellar winds. We determine the size of a corona that is necessary to produce the overall ionization conditions in zeta Pup as has been deduced by Olson from line profile analysis. In the ionization balance calculations we account for diffuse radiation field in the wind and for the large optical depths in the He II continuum due to radiative and Auger ionization edges of abundant elements. The X-ray flux transmitted through the wind is calculated and compared with upper limits derived for upper limits derived for zeta Pup observations from ANS and Uhuru satellites. It is found that a coronal zone with a temperature of 5x10 6 K and a volume emission measure of 10 58 cm -3 can produce the required ionization in a wind having a temperature of 30,000--35,000 K. The emergent X-ray flux bears little resemblance to the coronal emissivity because of the opacity of the wind. The X-ray flux nearly reaches the upper limits derived from the ANS observations and, at several energy bands, should be detectable by the HEAO B satellite. A simplified analysis of the Auger ionization process is developed and applied to other Of and OB supergiants. We find that the model can explain the presence of C IV and Si IV in supergaints with effective temperatures as low as 12,000 K and can explain the appearance of O VI and N V lines in early type supergiants as late as BO.5 and B2, respectively

  12. EVIDENCE FOR DELAYED MASSIVE STAR FORMATION IN THE M17 PROTO-OB ASSOCIATION

    International Nuclear Information System (INIS)

    Povich, Matthew S.; Whitney, Barbara A.

    2010-01-01

    Through analysis of archival images and photometry from the Spitzer GLIMPSE and MIPSGAL surveys combined with Two Micron All Sky Survey and MSX data, we have identified 488 candidate young stellar objects (YSOs) in the giant molecular cloud M17 SWex, which extends ∼50 pc southwest from the prominent Galactic H II region M17. Our sample includes >200 YSOs with masses >3 M sun that will become B-type stars on the main sequence. Extrapolating over the stellar initial mass function (IMF), we find that M17 SWex contains >1.3 x 10 4 young stars, representing a proto-OB association. The YSO mass function is significantly steeper than the Salpeter IMF, and early O stars are conspicuously absent from M17 SWex. Assuming M17 SWex will form an OB association with a Salpeter IMF, these results reveal the combined effects of (1) more rapid circumstellar disk evolution in more massive YSOs and (2) delayed onset of massive star formation.

  13. La binaria LSS 3074 y su entorno: ?`una nueva asociación OB?

    Science.gov (United States)

    Niemela, V.; Morrell, N.; Corti, M.

    En este trabajo presentamos un nuevo análisis orbital de LSS~3074, junto con tipos espectrales y velocidades radiales de estrellas que podrían constituir con ella una nueva asociación OB. La estrella O4f LSS3074 fue descubierta como binaria espectroscópica de corto período y líneas dobles por Morrell & Niemela (1990, ASP Conf. Ser. 7, 57). Posteriormente, Haefner et~al.(1994, IBVS 3969) encontraron variaciones fotométricas, estimando una inclinación orbital entre 50o y 55o. Teniendo en cuenta la importancia de obtener valores empíricos para las masas de estrellas O tempranas, y considerando la gran dispersión existente entre los valores observados y su discrepancia con los predichos por los modelos teóricos, hemos obtenido nuevas observaciones espectroscópicas de este sistema, con el propósito de mejorar los elementos orbitales derivados en la solución preliminar. Además, como las estrellas O tempranas suelen formar parte de cúmulos y asociaciones OB, hemos llevado a cabo una investigación espectroscópica de varias estrellas tempranas que podrían estar físicamente relacionadas con LSS~3074.

  14. Into the Darkness: Interstellar Extinction Near the Cepheus OB3 Molecular Cloud

    Science.gov (United States)

    Fitzpatrick, Edward L.; Jacklin, S.; Massa, D.

    2014-01-01

    We present the results of a followup investigation to a study performed by Massa and Savage (1984, ApJ, 279, 310) of the properties of UV interstellar extinction in the region of the Cepheus OB3 molecular cloud. That study was performed using UV photometry and spectro-photometry from the ANS and IUE satellites. We have extended this study into the IR, utilizing the uniform database of IR photometry available from the 2MASS project. This is a part of a larger program whose goal is to study the properties of extinction in localized regions, where we hope to find clues to dust grain growth and destruction processes through spatial correlations of extinction with distinct environmental properties. Similarly to Massa and Savage’s UV results, we find that the IR extinction properties on the Cepheus OB3 region vary systematically with the apparent proximity of the target stars to the molecular cloud. We also find that the UV extinction and the IR extinction are crudely correlated. The methodology leading to these results and their implications are discussed.

  15. OB Stars and Cepheids From the Gaia TGAS Catalogue: Test of their Distances and Proper Motions

    Directory of Open Access Journals (Sweden)

    Bobylev Vadim V.

    2017-12-01

    Full Text Available We consider young distant stars from the Gaia TGAS catalog. These are 250 classical Cepheids and 244 OB stars located at distances up to 4 kpc from the Sun. These stars are used to determine the Galactic rotation parameters using both trigonometric parallaxes and proper motions of the TGAS stars. In this case the considered stars have relative parallax errors less than 200%. Following the well-known statistical approach, we assume that the kinematic parameters found from the line-of-sight velocities Vr are less dependent on errors of distances than the found from the velocity components Vl. From values of the first derivative of the Galactic rotation angular velocity ′0, found from the analysis of velocities Vr and Vl separately, the scale factor of distances is determined.We found that from the sample of Cepheids the scale of distances of the TGAS should be reduced by 3%, and from the sample of OB stars, on the contrary, the scale should be increased by 9%.

  16. A CANDIDATE FOR THE MOST LUMINOUS OB ASSOCIATION IN THE GALAXY

    International Nuclear Information System (INIS)

    Rahman, Mubdi; Matzner, Christopher; Moon, Dae-Sik

    2011-01-01

    The Milky Way harbors giant H II regions, which may be powered by star complexes more luminous than any known Galactic OB association. Being across the disk of the Galaxy, however, these brightest associations are severely extinguished and confused. We present a search for one such association toward the most luminous H II region in the recent catalog by Murray and Rahman, which, at ∼9.7 kpc, has a recombination rate of ∼7 x 10 51 s -1 . Prior searches have identified only small-scale clustering around the rim of this shell-like region, but the primary association has not previously been identified. We apply a near-infrared color selection and find an overdensity of point sources toward its southern central part. The colors and magnitudes of these excess sources are consistent with O- and early B-type stars at extinctions 0.96 K < 1.2, and they are sufficiently numerous (406 ± 102 after subtraction of field sources) to ionize the surrounding H II region, making this a candidate for the most luminous OB association in the Galaxy. We reject an alternate theory, in which the apparent excess is caused by localized extinction, as inconsistent with source demographics.

  17. Analysis of interstellar extinction towards the hypergiant Cyg OB2 No. 12

    Science.gov (United States)

    Maryeva, O. V.; Chentsov, E. L.; Goranskij, V. P.; Karpov, S. V.

    The Cyg OB2 stellar association hosts an entire zoo of unique objects, and among them -- an enigmatic star Cyg OB2 No. 12 (Schulte 12, MT 304). MT 304 is enigmatic not only due to its highest luminosity (according to various estimates, it is one of the brightest stars in the Galaxy), but also because its reddening is anomalously large, greater than the mean reddening in the association. To explain the nature of anomalous reddening (AV≃ 10 mag) of MT 304, we carried out spectrophotometric observations of 25 stars located in its vicinity. We mapped interstellar extinction within the 2.5 arcmin radius and found it to increase towards MT 304. According to our results, the two most reddened stars in the association after MT 304 are J203240.35+411420.1 and J203239.90+411436.2, both located about 15 arcsec from it. Interstellar extinction AV towards these stars is about 9 mag. Our results favor the hypothesis of the circumstellar nature of reddening excess. In the second part of the paper we present the results of our modeling of MT 282 (B1 IV) and MT 343 (B1 V), which belong to the older population of the association and have ages greater than 10 Myr.

  18. The structure of KPN03535 (gi|152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold

    International Nuclear Information System (INIS)

    Das, Debanu; Kozbial, Piotr; Han, Gye Won; Carlton, Dennis; Jaroszewski, Lukasz; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Bakolitsa, Constantina; Chen, Connie; Chiu, Hsiu-Ju; Chiu, Michelle; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Ellrott, Kyle; Elsliger, Marc-André; Ernst, Dustin; Farr, Carol L.; Feuerhelm, Julie; Grzechnik, Anna; Grant, Joanna C.; Jin, Kevin K.; Johnson, Hope A.; Klock, Heath E.; Knuth, Mark W.; Krishna, S. Sri; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Miller, Mitchell D.; Morse, Andrew T.; Nigoghossian, Edward; Nopakun, Amanda; Okach, Linda; Oommachen, Silvya; Paulsen, Jessica; Puckett, Christina; Reyes, Ron; Rife, Christopher L.; Sefcovic, Natasha; Tien, Henry J.; Trame, Christine B.; Bedem, Henry van den; Weekes, Dana; Wooten, Tiffany; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-01-01

    KPN03535 is a protein unique to K. pneumoniae. The crystal structure reveals that KPN03535 represents a novel variant of the OB-fold and is likely to be a DNA-binding lipoprotein. KPN03535 (gi|152972051) is a putative lipoprotein of unknown function that is secreted by Klebsiella pneumoniae MGH 78578. The crystal structure reveals that despite a lack of any detectable sequence similarity to known structures, it is a novel variant of the OB-fold and structurally similar to the bacterial Cpx-pathway protein NlpE, single-stranded DNA-binding (SSB) proteins and toxins. K. pneumoniae MGH 78578 forms part of the normal human skin, mouth and gut flora and is an opportunistic pathogen that is linked to about 8% of all hospital-acquired infections in the USA. This structure provides the foundation for further investigations into this divergent member of the OB-fold family

  19. Far-infrared and CO observations of Cep F: Implications for star formation in Cepheus OB3

    International Nuclear Information System (INIS)

    Sargent, A.I.; van Duinen, R.J.; Nordh, H.L.; Fridlund, C.V.M.; Aalders, J.W.G.; Beintema, D.

    1983-01-01

    Observations at 80-μm and 130-μm have revealed a source of far-infrared emission in the Cep F portion of the Cepheus OB3 molecular cloud. Molecular line measurements of this region, at the CO J = 1-0 line frequency, have led to the discovery of two CO maxima. One of these coincides with the new far-infrared source. The other is at least as intense as Cep B, until now considered to be the hottest part of the cloud. There is some evidence to suggest that a second far-infrared source is associated with this hotspot. If the far-infrared emission results from the presence of embedded protostars, their location, relative to the OB association stars and to the other active region, Cep A, requires a reexamination of how stars form in the Cepheus OB3 association

  20. Toward Complete Statistics of Massive Binary Stars: Penultimate Results from the Cygnus OB2 Radial Velocity Survey

    OpenAIRE

    Kobulnicky, Henry A.; Kiminki, Daniel C.; Lundquist, Michael J.; Burke, Jamison; Chapman, James; Keller, Erica; Lester, Kathryn; Rolen, Emily K.; Topel, Eric; Bhattacharjee, Anirban; Smullen, Rachel A.; Alvarez, Carlos A. Vargas; Runnoe, Jessie C.; Dale, Daniel A.; Brotherton, Michael M.

    2014-01-01

    We analyze orbital solutions for 48 massive multiple-star systems in the Cygnus OB2 Association, 23 of which are newly presented here, to find that the observed distribution of orbital periods is approximately uniform in log P for P 45 d, even after correction for completeness, indicating either a lower binary fraction or a shift toward low-mass companions. A high degree of similarity (91% likelihood) between the Cyg OB2 period distribution and that of other surveys suggests that the binary p...

  1. Asteroseismology of OB stars with hundreds of single snapshot spectra (and a few time-series of selected targets)

    Science.gov (United States)

    Simón-Díaz, S.

    2015-01-01

    Imagine we could do asteroseismology of large samples of OB-type stars by using just one spectrum per target. That would be great! But this is probably a crazy and stupid idea. Or maybe not. Maybe we have the possibility to open a new window to investigate stellar oscillations in massive stars that has been in front of us for many years, but has not attracted very much our attention: the characterization and understanding of the so-called macroturbulent broadening in OB-type stars.

  2. Optimal Inversion Parameters for Full Waveform Inversion using OBS Data Set

    Science.gov (United States)

    Kim, S.; Chung, W.; Shin, S.; Kim, D.; Lee, D.

    2017-12-01

    In recent years, full Waveform Inversion (FWI) has been the most researched technique in seismic data processing. It uses the residuals between observed and modeled data as an objective function; thereafter, the final subsurface velocity model is generated through a series of iterations meant to minimize the residuals.Research on FWI has expanded from acoustic media to elastic media. In acoustic media, the subsurface property is defined by P-velocity; however, in elastic media, properties are defined by multiple parameters, such as P-velocity, S-velocity, and density. Further, the elastic media can also be defined by Lamé constants, density or impedance PI, SI; consequently, research is being carried out to ascertain the optimal parameters.From results of advanced exploration equipment and Ocean Bottom Seismic (OBS) survey, it is now possible to obtain multi-component seismic data. However, to perform FWI on these data and generate an accurate subsurface model, it is important to determine optimal inversion parameters among (Vp, Vs, ρ), (λ, μ, ρ), and (PI, SI) in elastic media. In this study, staggered grid finite difference method was applied to simulate OBS survey. As in inversion, l2-norm was set as objective function. Further, the accurate computation of gradient direction was performed using the back-propagation technique and its scaling was done using the Pseudo-hessian matrix.In acoustic media, only Vp is used as the inversion parameter. In contrast, various sets of parameters, such as (Vp, Vs, ρ) and (λ, μ, ρ) can be used to define inversion in elastic media. Therefore, it is important to ascertain the parameter that gives the most accurate result for inversion with OBS data set.In this study, we generated Vp and Vs subsurface models by using (λ, μ, ρ) and (Vp, Vs, ρ) as inversion parameters in every iteration, and compared the final two FWI results.This research was supported by the Basic Research Project(17-3312) of the Korea Institute of

  3. Variable millimetre radiation from the colliding-wind binary Cygnus OB2 #8A

    Science.gov (United States)

    Blomme, R.; Fenech, D. M.; Prinja, R. K.; Pittard, J. M.; Morford, J. C.

    2017-12-01

    Context. Massive binaries have stellar winds that collide. In the colliding-wind region, various physically interesting processes occur, leading to enhanced X-ray emission, non-thermal radio emission, as well as non-thermal X-rays and gamma-rays. Non-thermal radio emission (due to synchrotron radiation) has so far been observed at centimetre wavelengths. At millimetre wavelengths, the stellar winds and the colliding-wind region emit more thermal free-free radiation, and it is expected that any non-thermal contribution will be difficult or impossible to detect. Aims: We aim to determine if the material in the colliding-wind region contributes substantially to the observed millimetre fluxes of a colliding-wind binary. We also try to distinguish the synchrotron emission from the free-free emission. Methods: We monitored the massive binary Cyg OB2 #8A at 3 mm with the NOrthern Extended Millimeter Array (NOEMA) interferometer of the Institut de Radioastronomie Millimétrique (IRAM). The data were collected in 14 separate observing runs (in 2014 and 2016), and provide good coverage of the orbital period. Results: The observed millimetre fluxes range between 1.1 and 2.3 mJy, and show phase-locked variability, clearly indicating that a large part of the emission is due to the colliding-wind region. A simple synchrotron model gives fluxes with the correct order of magnitude, but with a maximum that is phase-shifted with respect to the observations. Qualitatively this phase shift can be explained by our neglect of orbital motion on the shape of the colliding-wind region. A model using only free-free emission results in only a slightly worse explanation of the observations. Additionally, on the map of our observations we also detect the O6.5 III star Cyg OB2 #8B, for which we determine a 3 mm flux of 0.21 ± 0.033 mJy. Conclusions: The question of whether synchrotron radiation or free-free emission dominates the millimetre fluxes of Cyg OB2 #8A remains open. More detailed

  4. ObsPy: Establishing and maintaining an open-source community package

    Science.gov (United States)

    Krischer, L.; Megies, T.; Barsch, R.

    2017-12-01

    Python's ecosystem evolved into one of the most powerful and productive research environment across disciplines. ObsPy (https://obspy.org) is a fully community driven, open-source project dedicated to provide a bridge for seismology into that ecosystem. It does so by offering Read and write support for essentially every commonly used data format in seismology, Integrated access to the largest data centers, web services, and real-time data streams, A powerful signal processing toolbox tuned to the specific needs of seismologists, and Utility functionality like travel time calculations, geodetic functions, and data visualizations. ObsPy has been in constant unfunded development for more than eight years and is developed and used by scientists around the world with successful applications in all branches of seismology. By now around 70 people directly contributed code to ObsPy and we aim to make it a self-sustaining community project.This contributions focusses on several meta aspects of open-source software in science, in particular how we experienced them. During the panel we would like to discuss obvious questions like long-term sustainability with very limited to no funding, insufficient computer science training in many sciences, and gaining hard scientific credits for software development, but also the following questions: How to best deal with the fact that a lot of scientific software is very specialized thus usually solves a complex problem but at the same time can only ever reach a limited pool of developers and users by virtue of it being so specialized? Therefore the "many eyes on the code" approach to develop and improve open-source software only applies in a limited fashion. An initial publication for a significant new scientific software package is fairly straightforward. How to on-board and motivate potential new contributors when they can no longer be lured by a potential co-authorship? When is spending significant time and effort on reusable

  5. MODELING THE RADIO EMISSION FROM Cyg OB2 NO. 5: A QUADRUPLE SYSTEM?

    International Nuclear Information System (INIS)

    Kennedy, M.; Dougherty, S. M.; Fink, A.; Williams, P. M.

    2010-01-01

    Fifty observations at frequencies between 1.4 GHz and 43 GHz of the 6.6 day O6.5-7+O5.5-6 binary Cyg OB2 No. 5 using the Very Large Array over 20 years are re-examined. The aim is to determine the location and character of the previously detected variable radio emission. The radio emission from the system consists of a primary component that is associated with the binary, and a non-thermal source (NE), 0.''8 to the NE of the binary that has been ascribed to a wind-collision region (WCR) between the stellar winds of the binary and that of a B-type star (Star D) to the NE. Previous studies have not accounted for the potential contribution of NE to the total radio emission, most especially in observations where the primary and NE sources are not resolved as separate sources. NE shows no evidence of variation in 23 epochs where it is resolved separately from the primary radio component, demonstrating that the variable emission arises in the primary component. Since NE is non-variable, the radio flux from the primary can now be well determined for the first time, most especially in observations that do not resolve both the primary and NE components. The variable radio emission from the primary component has a period of 6.7 ± 0.3 years which is described by a simple model of a non-thermal source orbiting within the stellar wind envelope of the binary. Such a model implies the presence of a third, unresolved stellar companion (Star C) orbiting the 6.6 day binary with a period of 6.7 years and independent of Star D to the NE. The variable non-thermal emission arises from either a WCR between Star C and the binary system, or possibly from Star C directly. The model gives a mass-loss rate of 3.4 x 10 -5 M sun yr -1 for Cyg OB2 No. 5, unusually high for an Of supergiant and comparable to that of WR stars, and consistent with an unusually strong He I 1.083 μm emission line, also redolent of WR stars. An examination of radial velocity observations available from the

  6. A survey of formaldehyde in the Cepheus OB3 molecular cloud

    International Nuclear Information System (INIS)

    Few, R.W.; Cohen, R.J.

    1983-01-01

    The 1 11 - 1 10 absorption line of formaldehyde at 6-cm wavelength has been surveyed over the region of the Cepheus OB3 molecular cloud, using the Jodrell Bank Mk II radio telescope (beamwidth 9 x 10 arcmin 2 ). The measurements have a velocity resolution of 0.27 km s - 1 and an rms noise level of approx. 0.01 K. The formaldehyde has a very clumpy distribution which is broadly similar to the CO distribution found by Sargent. A total molecular mass of 1.9 x 10 4 solar masses is implied by the formaldehyde measurements. Cepheus A is not the dominant concentration in the formaldehyde map. The most massive formaldehyde concentration is Cepheus C, which has a mass of 3600 solar masses. It appears to be stabilized by rotation. (author)

  7. Nonvariceal upper gastrointestinal bleeding

    International Nuclear Information System (INIS)

    Burke, Stephen J.; Weldon, Derik; Sun, Shiliang; Golzarian, Jafar

    2007-01-01

    Nonvariceal upper gastrointestinal bleeding (NUGB) remains a major medical problem even after advances in medical therapy with gastric acid suppression and cyclooxygenase (COX-2) inhibitors. Although the incidence of upper gastrointestinal bleeding presenting to the emergency room has slightly decreased, similar decreases in overall mortality and rebleeding rate have not been experienced over the last few decades. Many causes of upper gastrointestinal bleeding have been identified and will be reviewed. Endoscopic, radiographic and angiographic modalities continue to form the basis of the diagnosis of upper gastrointestinal bleeding with new research in the field of CT angiography to diagnose gastrointestinal bleeding. Endoscopic and angiographic treatment modalities will be highlighted, emphasizing a multi-modality treatment plan for upper gastrointestinal bleeding. (orig.)

  8. Nonvariceal upper gastrointestinal bleeding

    Energy Technology Data Exchange (ETDEWEB)

    Burke, Stephen J.; Weldon, Derik; Sun, Shiliang [University of Iowa, Department of Radiology, Iowa, IA (United States); Golzarian, Jafar [University of Iowa, Department of Radiology, Iowa, IA (United States); University of Iowa, Department of Radiology, Carver College of Medicine, Iowa, IA (United States)

    2007-07-15

    Nonvariceal upper gastrointestinal bleeding (NUGB) remains a major medical problem even after advances in medical therapy with gastric acid suppression and cyclooxygenase (COX-2) inhibitors. Although the incidence of upper gastrointestinal bleeding presenting to the emergency room has slightly decreased, similar decreases in overall mortality and rebleeding rate have not been experienced over the last few decades. Many causes of upper gastrointestinal bleeding have been identified and will be reviewed. Endoscopic, radiographic and angiographic modalities continue to form the basis of the diagnosis of upper gastrointestinal bleeding with new research in the field of CT angiography to diagnose gastrointestinal bleeding. Endoscopic and angiographic treatment modalities will be highlighted, emphasizing a multi-modality treatment plan for upper gastrointestinal bleeding. (orig.)

  9. New Partner Recruitment to Rural Versus Urban Ob-Gyn Practices

    Directory of Open Access Journals (Sweden)

    Michael F. Fialkow

    2017-09-01

    Full Text Available Purpose: The purpose of this pilot study was to investigate the recruitment efforts of practicing obstetrics and gynecology (ob-gyns from rural and urban practices. Method: The authors surveyed practicing ob-gyns from 5 states in the Pacific Northwest in 2016 about their background, practice setting, practice profile, partner recruitment, and retention. Results: Seventy-three patients completed the study (53.2% response rate. Thirty-seven percent of respondents work in an urban practice and 43% have a rural practice, with the remainder in a suburban setting. A majority of the respondents attempted to recruit a new partner in the past 5 years. Respondents were most interested in experience and diversity in new recruits. Urban respondents, however, were more interested in hiring those with specialized skills (χ 2 = 7.842, P = .02 than rural providers who were more interested in partners familiar with their community (χ 2 = 7.153, P = .03. Reasons most often cited to leave their practice were reimbursement, limited social/marital options, and workload, other than rural providers who more often also cited lack of access to specialty care (χ 2 = 13.256, P = .001. Rural providers were more likely to cite marital and family status as an advantage to recruitment, whereas urban and suburban providers were more often neutral. Conclusions: Reduced access to care has led to significant health disparities for women living in rural communities. Understanding which providers are most likely to be successful in these settings might help preserve access as our health-care systems evolves.

  10. SCUBA and HIRES Results for Protostellar Cores in the MON OB1 Dark Cloud

    Science.gov (United States)

    Wolf-Chase, G.; Moriarty-Schieven, G.; Fich, M.; Barsony, M.

    1999-05-01

    We have used HIRES-processing of IRAS data and point-source modelling techniques (Hurt & Barsony 1996; O'Linger 1997; Barsony et al. 1998), together with submillimeter continuum imaging using the Submillimeter Common-User Bolometer Array (SCUBA) on the 15-meter James Clerk Maxwell Telescope (JCMT), to search CS cores in the Mon OB1 dark cloud (Wolf-Chase, Walker, & Lada 1995; Wolf-Chase & Walker 1995) for deeply embedded sources. These observations, as well as follow-up millimeter photometry at the National Radio Astronomy Observatory (NRAO) 12-meter telescope on Kitt Peak, have lead to the identification of two Class 0 protostellar candidates, which were previously unresolved from two brighter IRAS point sources (IRAS 06382+0939 & IRAS 06381+1039) in this cloud. Until now, only one Class 0 object had been confirmed in Mon OB1; the driving source of the highly-collimated outflow NGC 2264 G (Ward-Thompson, Eiroa, & Casali 1995; Margulis et al. 1990; Lada & Fich 1996), which lies well outside the extended CS cores. One of the new Class 0 candidates may be an intermediate-mass source associated with an H_2O maser, and the other object is a low-mass source which may be associated with a near-infrared jet, and possibly with a molecular outflow. We report accurate positions for the new Class 0 candidates, based on the SCUBA images, and present new SEDs for these sources, as well as for the brighter IRAS point sources. A portion of this work was performed while GWC held a President's Fellowship from the University of California. MB and GWC gratefully acknowledge financial support from MB's NSF CAREER Grant, AST97-9753229.

  11. Evaluating the probiotic and therapeutic potentials of Saccharomyces cerevisiae strain (OBS2) isolated from fermented nectar of toddy palm.

    Science.gov (United States)

    Srinivas, Banoth; Rani, Ganapathiwar Swarupa; Kumar, Bhukya Kiran; Chandrasekhar, Banoth; Krishna, Kommalapati Vamsi; Devi, Tangutur Anjana; Bhima, Bhukya

    2017-12-01

    The purpose of this study is to evaluate the probiotic characteristics of 15 yeast strains isolated from nectar of toddy palm. Initially, the collected samples were inoculated on yeast extract peptone dextrose agar plates and the colonies so obtained were culturally and morphologically characterized. Commercial probiotic yeast, Saccharomyces boulardii served as the control in these experiments. Of the 15 yeast strains, the isolates that were resistant to antibiotics and worked synergistically with other cultures were considered for further evaluation. Selected isolates were evaluated in vitro for tolerance to simulated gastrointestinal conditions such as temperature, pH, bile and gastric juice. Further the yeast isolates were evaluated for their pathogenicity and adherence to intestinal epithelial cells. The 2 yeast isolates with efficient probiotic properties were finally characterized by sequencing their 5.8 S rRNA and partial sequences of internal transcribed spacer 1 and 2. The sequences were BLAST searched in the National Center for Biotechnology Information, nucleic acid database for sequence similarity of organisms and phylogenetic evolutionary analysis was carried out. Based on maximum similarity of basic local alignment search tool results, organisms were characterized as Pichia kudriavzevii OBS1 (100%) and Saccharomyces cerevisiae OBS2 (96%) and sequences were finally deposited in the GenBank data library. Among these two isolates, S. cerevisiae OBS2 displayed slight/moderate antioxidant and anticancer property. Hence, strain OBS2 can be utilized and explored as a potential probiotic for therapeutic applications.

  12. Attenuation of S-waves in the lithosphere of the Sea of Crete according to OBS observations

    Science.gov (United States)

    Kovachev, S. A.; Kuzin, I. P.; Shoda, O. Yu.; Soloviev, S. L.

    1991-11-01

    Five OBS were installed in the Sea of Crete in 1987. During a period of nine days 430 local earthquakes were recorded. Hypocentres were determined for 85 microearthquakes. A correlation between magnitude ML and duration of seismic events on the records of the ocean bottom seismographs (OBS) was found from data of 14 shocks recorded simultaneously by OBS and some land-based Greek stations. A magnitude-frequency relationship for earthquakes recorded by OBS was obtained in the magnitude range ML = 2-4. Amplitude curves describing the attenuation of body waves in the lithosphere of the Sea of Crete were compiled. Assessment of quality factor Qs was made by comparison of empirical and theoretical amplitude curves. The values of Qs for the lithosphere of the Sea of Crete were calculated and found equal to 200-300. Low values of Qs and consequently strong attenuation of S-waves in the lithosphere of the Sea of Crete could be explained by extension of the lithosphere accompanied by its partial contamination with melted magma.

  13. Lutter contre l'obésité en Afrique du Sud à l'aide des politiques fiscales

    International Development Research Centre (IDRC) Digital Library (Canada)

    17 nov. 2016 ... En 2008, le fardeau total des maladies non transmissibles en Afrique du Sud était estimé à 40 %, et ne cessait de croître. L'obésité est un facteur de risque de plusieurs maladies non transmissibles, dont les cardiopathies, l'hypertension, le diabète et le cancer.

  14. B fields in OB stars (BOB): Low-resolution FORS2 spectropolarimetry of the first sample of 50 massive stars

    NARCIS (Netherlands)

    Fossati, L.; Castro, N.; Schöller, M.; Hubrig, S.; Langer, N.; Morel, T.; Briquet, M.; Herrero, A.; Przybilla, N.; Sana, H.; Schneider, F.R.N.; de Koter, A.

    2015-01-01

    Within the context of the collaboration "B fields in OB stars" (BOB), we used the FORS2 low-resolution spectropolarimeter to search for a magnetic field in 50 massive stars, including two reference magnetic massive stars. Because of the many controversies of magnetic field detections obtained with

  15. Case Study of Data Mining in Observational Astronomy: The Search for New OB Stars in the Small Magellanic Cloud

    Science.gov (United States)

    Larkin, Cormac; Vink, Jorick; Kalari, Venu; Groh, Jose

    2018-01-01

    OB stars are the most luminous and massive stars, living short lives and exerting a disproportionate influence on their environments. They are key to understanding progenitors of gravitational wave sources and reionization of the early Universe. To detect new OB stars, we combine photometric catalog data with TLUSTY and ATLAS9 stellar atmospheres. This method is also believed to be sensitive to elusive “stripped” stars, thought to lose their hydrogen envelope through binary interaction.OB stars are intrinsically luminous, so complete populations are assumed for local group galaxies such as the Small Magellanic Cloud. Our findings challenge this, as we find 26 new OB candidates. Spectroscopy of 7 candidates shows a 100% detection rate. Most interestingly, 5 of our candidates are consistent with “stripped” stars.To date only 5 “stripped” candidates have been found serendipitously (e.g. HD 45166) as current methods are not sensitive to them. Our work doubles the sample of detected candidates, highlighting that our approach is the first to identify them in a targeted, systematic way. The finding of “stripped” stars could rewrite our understanding of the early Universe, offering an alternative hypothesis to Wolf-Rayet driven cosmic reionization.

  16. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase.

    Science.gov (United States)

    Wang, Li Kai; Nair, Pravin A; Shuman, Stewart

    2008-08-22

    NAD(+)-dependent DNA ligases (LigAs) are ubiquitous in bacteria and essential for growth. LigA enzymes have a modular structure in which a central catalytic core composed of nucleotidyltransferase and oligonucleotide-binding (OB) domains is linked via a tetracysteine zinc finger to distal helix-hairpin-helix (HhH) and BRCT (BRCA1-like C-terminal) domains. The OB and HhH domains contribute prominently to the protein clamp formed by LigA around nicked duplex DNA. Here we conducted a structure-function analysis of the OB and HhH domains of Escherichia coli LigA by alanine scanning and conservative substitutions, entailing 43 mutations at 22 amino acids. We thereby identified essential functional groups in the OB domain that engage the DNA phosphodiester backbone flanking the nick (Arg(333)); penetrate the minor grove and distort the nick (Val(383) and Ile(384)); or stabilize the OB fold (Arg(379)). The essential constituents of the HhH domain include: four glycines (Gly(455), Gly(489), Gly(521), Gly(553)), which bind the phosphate backbone across the minor groove at the outer margins of the LigA-DNA interface; Arg(487), which penetrates the minor groove at the outer margin on the 3 (R)-OH side of the nick; and Arg(446), which promotes protein clamp formation via contacts to the nucleotidyltransferase domain. We find that the BRCT domain is required in its entirety for effective nick sealing and AMP-dependent supercoil relaxation.

  17. Methanobactin from Methylocystis sp. strain SB2 affects gene expression and methane monooxygenase activity in Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Farhan Ul-Haque, Muhammad; Kalidass, Bhagyalakshmi; Vorobev, Alexey; Baral, Bipin S; DiSpirito, Alan A; Semrau, Jeremy D

    2015-04-01

    Methanotrophs can express a cytoplasmic (soluble) methane monooxygenase (sMMO) or membrane-bound (particulate) methane monooxygenase (pMMO). Expression of these MMOs is strongly regulated by the availability of copper. Many methanotrophs have been found to synthesize a novel compound, methanobactin (Mb), that is responsible for the uptake of copper, and methanobactin produced by Methylosinus trichosporium OB3b plays a key role in controlling expression of MMO genes in this strain. As all known forms of methanobactin are structurally similar, it was hypothesized that methanobactin from one methanotroph may alter gene expression in another. When Methylosinus trichosporium OB3b was grown in the presence of 1 μM CuCl2, expression of mmoX, encoding a subunit of the hydroxylase component of sMMO, was very low. mmoX expression increased, however, when methanobactin from Methylocystis sp. strain SB2 (SB2-Mb) was added, as did whole-cell sMMO activity, but there was no significant change in the amount of copper associated with M. trichosporium OB3b. If M. trichosporium OB3b was grown in the absence of CuCl2, the mmoX expression level was high but decreased by several orders of magnitude if copper prebound to SB2-Mb (Cu-SB2-Mb) was added, and biomass-associated copper was increased. Exposure of Methylosinus trichosporium OB3b to SB2-Mb had no effect on expression of mbnA, encoding the polypeptide precursor of methanobactin in either the presence or absence of CuCl2. mbnA expression, however, was reduced when Cu-SB2-Mb was added in both the absence and presence of CuCl2. These data suggest that methanobactin acts as a general signaling molecule in methanotrophs and that methanobactin "piracy" may be commonplace. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  18. A 80 OBS and 30 Land 3-component seismometers array encompassing the 280 km segment of the Lesser Antilles subduction megathrust seismogenic zone: view of current seismicity

    Science.gov (United States)

    Laigle, Mireille; Sapin, Martine; Ruiz, Mario; Diaz, Jordi; Kissling, Edi; Charvis, Philippe; Flueh, Ernst; Hirn, Alfred

    2010-05-01

    An extensive onshore and offshore seismic station array in the Lesser Antilles subduction zone allows to monitor microearthquake activity for a period of 4 months in a region previously outside of reach for detailed observation. Such a network has been possible thanks to a cluster of 3 seismic surveys (TRAIL - F/S Merian, SISMANTILLESII - N/O Atalante, and OBSANTILLES - N/O Antea) for deploying and recovering the instruments from several pools (Geoazur, INSU-IPGP, IFM-GEOMAR, AWI ). It has been followed by an additional deployment of the 28 GeoAzur OBSs (OBSANTILLES - N/O Antea) during 5 months in the south-western half. These operations have been carried out for the seismic investigation of the Antilles megathrust seismogenic zone in the framework of the THALES WAS RIGHT european project, and with also the financial support of the french ANR Catastrophes Telluriques et Tsunamis (SUBSISMANTI) and by the EU SALVADOR Programme of IFM-GEOMAR. Onshore, 30 3-components land stations (CSIC Barcelone, IPG Paris, INSU-RLBM and -LITHOSCOPE) have been temporarily deployed. The deep seismic structure of the whole area has been investigated during these seismic surveys by wide-angle reflection and refraction seismics recorded by these instruments as well as multi-channel reflection seismic imaging (MCS) along a dense grid of crossing profiles at the OBS positions providing excellent velocity information for the upper plate. Both the location and the interpretation of the recorded earthquake activity require constraints on the deep seismic structure, which will be discussed with respect to the 3D geometry of the interplate boundary and oceanic Moho, as well as those of the forearc basement and Moho. Preliminary locations have been obtained within a simple 1D velocity model by taking into account corrections for the variable thickness of the mud- and sediments layers beneath each OBS. The latter are estimated for both P- and S-waves to compensate for the huge structural

  19. Upper respiratory tract (image)

    Science.gov (United States)

    The major passages and structures of the upper respiratory tract include the nose or nostrils, nasal cavity, mouth, throat (pharynx), and voice box (larynx). The respiratory system is lined with a mucous membrane that ...

  20. ACA Federal Upper Limits

    Data.gov (United States)

    U.S. Department of Health & Human Services — Affordable Care Act Federal Upper Limits (FUL) based on the weighted average of the most recently reported monthly average manufacturer price (AMP) for...

  1. Upper gastrointestinal bleeding.

    Science.gov (United States)

    Feinman, Marcie; Haut, Elliott R

    2014-02-01

    Upper gastrointestinal (GI) bleeding remains a commonly encountered diagnosis for acute care surgeons. Initial stabilization and resuscitation of patients is imperative. Stable patients can have initiation of medical therapy and localization of the bleeding, whereas persistently unstable patients require emergent endoscopic or operative intervention. Minimally invasive techniques have surpassed surgery as the treatment of choice for most upper GI bleeding. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Three-Dimensional Slowness Images of the Upper Crust Beneath the Lucky Strike Hydrothermal Vent Sites

    Science.gov (United States)

    Seher, T.; Crawford, W.; Singh, S.; Canales, J. P.; Combier, V.; Cannat, M.; Carton, H.; Dusunur, D.; Escartin, J.; Miranda, M. J.; Pouillet-Erguy, A.

    2005-12-01

    In June-July 2005 we carried out the SISMOMAR cruise, as part of the MOMAR project (Monitoring the Mid-Atlantic Ridge). Within this cruise, we conducted a 3D seismic reflection survey over an 18 km km x 3.8 km area covering both the Lucky Strike volcano and hydrothermal vents field. In order to have a full coverage inside the 3D box, shots continued for 2.25 km on either side of the box and extended out to the median valley bounding faults. To complement the streamer measurements 25 Ocean Bottom Seismometers (OBS) were placed in an 18 km x 18 km area. 11 OBS positions lie inside the 3D box and can be used to determine a very detailed image of the 3D velocity structure beneath the Lucky Strike volcano and hydrothermal vents field. For the 3D box a tuned array of 14 air guns (2600 cubic inches) was fired at an interval of 37.5 m for a total of 39 lines. We will present the first results of the OBS measurements near the Lucky Strike volcano. As a first step towards a joint 3D travel time and slowness (the inverse of velocity at turning depth) tomography, we present the 3D slowness function (latitude, longitude, offset), which can be considered as a 3D brute stack velocity image of the sub-surface (c.f. Barton and Edwards, 1999). The presence of fluid in the upper crust due to hydrothermal circulation should appear as a low velocity anomaly beneath the hydrothermal vents. In the next step the OBS measurements will be used to corroborate the reflection images of layer 2A observed in the streamer data for the 3D box. The OBS inside the 3D box recorded turning ray arrivals from the upper crust at a very fine sampling interval (37.5 m x 100 m) over a large azimuth. This provides the unique opportunity for jointly inverting travel time and slowness. Hence the measurements contain information on local gradients and should provide a very detailed velocity model of the subsurface, including information on hydrothermal systems and a possilbe anisotropy (e.g. Cherret and Singh

  3. Upper GI Bleeding in Children

    Science.gov (United States)

    Upper GI Bleeding in Children What is upper GI Bleeding? Irritation and ulcers of the lining of the esophagus, stomach or duodenum can result in upper GI bleeding. When this occurs the child may vomit blood ...

  4. Oligo-dT anchored cDNA-SCoT: a novel differential display method for analyzing differential gene expression in response to several stress treatments in mango (Mangifera indica L.).

    Science.gov (United States)

    Luo, Cong; He, Xin-Hua; Hu, Ying; Yu, Hai-xia; Ou, Shi-Jin; Fang, Zhong-Bin

    2014-09-15

    Differential display is a powerful technique for analyzing differences in gene expression. Oligo-dT cDNAstart codon targeted marker (cDNA-SCoT) technique is a novel, simple, cheap, rapid, and efficient method for differential gene expression research. In the present study, the oligo-dT anchored cDNA-SCoT technique was exploited to identify differentially expressed genes during several stress treatments in mango. A total of 37 primers combined with oligo-dT anchor primers 3side amplified approximately 150 fragments of 150 bp to 1500 bp in length. Up to 100 fragments were differentially expressed among the stress treatments and control samples, among which 92 were obtained and sequenced. Out of the 92 transcript derived fragments (TDFs), 70% were highly homologous to known genes, and 30% encoded unclassified proteins with unknown functions. The expression pattern of nine genes with known functions involved in several abiotic stresses in other species was confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) under cold (4 °C), salinity (NaCl), polyethylene glycol (PEG, MW 6000), and heavy metal treatments in leaves and stems at different time points (0, 24, 48, and 72 h). The expression patterns of the genes (TDF4, TDF7, TDF23, TDF45, TDF49, TDF50, TDF57, TDF91 and TDF92) that had direct or indirect relationships with cold, salinity, drought and heavy metal stress response were analyzed through qRT-PCR. The possible roles of these genes are discussed. This study suggests that the oligo-dT anchored cDNA-SCoT differential display method is a useful tool to serve as an initial step for characterizing transcriptional changes induced by abiotic stresses and provide gene information for further study and application in genetic improvement and breeding in mango. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Plutonium speciation and isotope ratios in Yenisey and Ob river and Yenisey estuary

    International Nuclear Information System (INIS)

    Skipperud, L.; Oughton, DH.; Fifield, K.; Lind, O.C.; Salbu, B.; Brown, J.

    2004-01-01

    Plutonium isotope ratios are known to vary with reactor type, nuclear fuel-burn up time, neutron flux, and energy, and for fallout from nuclear detonations, weapon type and yield. Weapons-grade plutonium is characterized by a low content of the 240 Pu isotope, with 240 Pu/ 239 Pu isotope ratio less than 0.05. In contrast, both global weapons fallout and spent nuclear fuel from civil reactors have higher 240 Pu/ 239 Pu isotope ratios (civil nuclear power reactors have 240 Pu/ 239 Pu atom ratios of between about 0.2-1). Thus, different sources often exhibit characteristic plutonium isotope ratios and these ratios can be used to identify the origin of contamination, calculate inventories, or follow the migration of contaminated sediments and waters. Together with activity measurements and isotope ratios, knowledge of plutonium speciation in the Ob and Yenisey rivers and processes controlling its behaviour in estuarine systems is a prerequisite for predicting the transfer and subsequent environmental impact to Arctic Seas. With this in mind, the study had two objectives: first to determine whether discharges from nuclear installations in the river catchment areas are having any influence on Pu levels in the estuaries; and, second, to investigate the transfer and mobility of plutonium in the Yenisey river and estuary. Plutonium 240/239 ratios were determined using accelerator mass spectrometry (AMS). The data indicated a clear influence from a low 240 Pu: 239 Pu source in surface sediments collected from the Yenisey Estuary, whereas plutonium in the Ob Estuary sediments are dominated by global fallout. The results also show an increase in plutonium concentration and a decrease in isotope ratio going upstream from the estuary. Sequential extractions of sediments indicate that up 70% of the Pu in the Yenisey river is easily mobilized with weak oxidizing agents, which indicates that the Pu is organically bound, while the Pu is more strongly irreversible bound further out

  6. Polimorfismos del gen ob en bovinos de raza holstein en la Comarca Lagunera, México

    Directory of Open Access Journals (Sweden)

    Sarai S. Mendoza-Retana

    2017-01-01

    Full Text Available La Comarca Lagunera es la cuenca lechera más importante de México. En la actualidad se están utilizando diversas técnicas que permiten evaluar genéticamente el animal a una edad temprana, permitiendo seleccionar futuros reproductores con características deseables. Entre los genes relacionados con la producción de leche, se encuentran el gen Ob también llamado gen Leptina el cual actúa sobre el sistema nervioso central y tejidos periféricos jugando un papel muy importante en la modulación regulación del apetito, ganancia de peso vivo, incremento del metabolismo energético y el anabolismo muscular. Este trabajo se realizó para determinar el polimorfismo de longitud del fragmento de restricción ACI I de gen leptina en el exón 2 y correlacionarlo con los parámetros de producción y calidad de leche. Se recolectaron 100 muestra de sangre de vacas en producción del establo “Lácteos Florida” de Francisco I. Madero municipio de Coahuila, México con tres esta tus de producción: altas, medias y bajas La extracción de ADN se realizó por el método modificado de Salting - Out. Se realizó PCR del gen leptina originando un fragmento de 272 bp de longitud y se realizó PCR - RFLP con la enzima de restricción ACI I y secue nciación, correlacionando los genotipos TT, CT Y CC con tres estatus de producción de leche: altas, medias, bajas. El análisis estadístico indicó que las vacas portadoras del genotipo homocigoto (TT tienen un efecto significativo (P<0.01 con respecto a l as características de producción y calidad de leche ya que tuvieron un mayor consumo de alimento, ganancia de peso, además de una elevada producción de leche en comparación a los genotipos heterocigoto (CT y homocigoto (CC. Los resultados obtenidos muest ran que l a identificación molecular de polimorfismos del gen Ob puede usarse como herramienta de selección genética en bovinos de raza Holstein.

  7. A Deuteration Survey of Starless Clumps in GemOB1 and the First Quadrant

    Science.gov (United States)

    Henrici, Andrew; Shirley, Yancy L.; Svoboda, Brian

    2018-01-01

    One very strong chemical process in star-forming regions is the fractionation of deuterium in molecules, which results in an increase in the deuterium ratio many orders of magnitude over the ISM [D]/[H] ratio and provides a chemical probe of cold, dense regions. Recent maps of dust continuum emission at (sub)millimeter wavelengths have identified tens of thousands of dense clumps of gas and dust. By comparing these regions to infrared and radio surveys, we have identified starless clump candidates which have no evidence for embedded star formation. These objects represent the earliest phase of star formation throughout the Milky Way. One benefit of the Milky Way surveys is that it is also possible to study the chemistry of entire core and clump populations within a single cloud. We used the 10m Heinrich Hertz Submillimeter Telescope to survey starless clump candidates in the First Quadrant identified from the Bolocam Galactic Plane Survey 1.1 mm continuum in the deuterated molecular transitions of DCO+ 3-2 and N2D+ 3-2. We also survey the entire clump population of the Gemini OB1 molecular cloud. In both surveys, we compared detection statistics and compare deuteration fraction to physical properties of the clumps and their evolutionary stage. High resolution ALMA observations of 9 starless clump candidates of the same lines are used to analyze how the cold deuterated gas is spatially distributed in these clumps.

  8. New Version of SeismicHandler (SHX) based on ObsPy

    Science.gov (United States)

    Stammler, Klaus; Walther, Marcus

    2016-04-01

    The command line version of SeismicHandler (SH), a scientific analysis tool for seismic waveform data developed around 1990, has been redesigned in the recent years, based on a project funded by the Deutsche Forschungsgemeinschaft (DFG). The aim was to address new data access techniques, simplified metadata handling and a modularized software design. As a result the program was rewritten in Python in its main parts, taking advantage of simplicity of this script language and its variety of well developed software libraries, including ObsPy. SHX provides an easy access to waveforms and metadata via arclink and FDSN webservice protocols, also access to event catalogs is implemented. With single commands whole networks or stations within a certain area may be read in, the metadata are retrieved from the servers and stored in a local database. For data processing the large set of SH commands is available, as well as the SH scripting language. Via this SH language scripts or additional Python modules the command set of SHX is easily extendable. The program is open source, tested on Linux operating systems, documentation and download is found at URL "https://www.seismic-handler.org/".

  9. Targeting the OB-Folds of Replication Protein A with Small Molecules

    Directory of Open Access Journals (Sweden)

    Victor J. Anciano Granadillo

    2010-01-01

    Full Text Available Replication protein A (RPA is the main eukaryotic single-strand (ss DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs that show in vitro inhibition of the RPA-DNA interaction. We present further characterization of these SMIs with respect to their target binding, mechanism of action, and specificity. Both reversible and irreversible modes of inhibition are observed for the different classes of SMIs with one class found to specifically interact with DNA-binding domains A and B (DBD-A/B of RPA. In comparison with other oligonucleotide/oligosaccharide binding-fold (OB-fold containing ssDNA-binding proteins, one class of SMIs displayed specificity for the RPA protein. Together these data demonstrate that the specific targeting of a protein-DNA interaction can be exploited towards interrogating the cellular activity of RPA as well as increasing the efficacy of DNA-damaging chemotherapeutics used in cancer treatment.

  10. SPITZER IRS SPECTRA OF DEBRIS DISKS IN THE SCORPIUS–CENTAURUS OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Jang-Condell, Hannah [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Chen, Christine H.; Mittal, Tushar; Lisse, Carey M. [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States); Manoj, P. [Department of Astronomy and Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha Rd., Mumbai 400005 (India); Watson, Dan [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Nesvold, Erika; Kuchner, Marc [NASA Goddard Space Flight Center, Greenbelt, MD (United States)

    2015-08-01

    We analyze spectra obtained with the Spitzer Infrared Spectrograph (IRS) of 110 B-, A-, F-, and G-type stars with optically thin infrared excess in the Scorpius–Centaurus OB association. The ages of these stars range from 11 to 17 Myr. We fit the infrared excesses observed in these sources by Spitzer IRS and the Multiband Imaging Photometer for Spitzer (MIPS) to simple dust models according to Mie theory. We find that nearly all of the objects in our study can be fit by one or two belts of dust. Dust around lower mass stars appears to be closer in than around higher mass stars, particularly for the warm dust component in the two-belt systems, suggesting a mass-dependent evolution of debris disks around young stars. For those objects with stellar companions, all dust distances are consistent with truncation of the debris disk by the binary companion. The gaps between several of the two-belt systems can place limits on the planets that might lie between the belts, potentially constraining the mass and locations of planets that may be forming around these stars.

  11. Central stars of planetary nebulae. II. New OB-type and emission-line stars

    Science.gov (United States)

    Weidmann, W. A.; Gamen, R.

    2011-07-01

    Context. There are more than 3000 confirmed and probably known Galactic planetary nebulae (PNe), but central star spectroscopic information is available for only 13% of them. Aims: We have undertaken a spectroscopic survey of the central stars in PNe to identify their spectral types. Methods: We performed spectroscopic observations at low resolution with the 2-m telescope at CASLEO, Argentina. Results: We present the spectra of 46 central stars of PNe, most of them are OB-type and emission-line stars. Based on data collected at the Complejo Astronómico El Leoncito (CASLEO), which is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina y Universidades Nacionales de La Plata, Córdoba y San Juan, Argentina.The reduced spectra (FITS files) are available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/531/A172

  12. DIRECT IMAGING AND SPECTROSCOPY OF A YOUNG EXTRASOLAR KUIPER BELT IN THE NEAREST OB ASSOCIATION

    International Nuclear Information System (INIS)

    Currie, Thayne; Lisse, Carey M.; Kuchner, Marc; Madhusudhan, Nikku; Kenyon, Scott J.; Thalmann, Christian; Carson, Joseph; Debes, John

    2015-01-01

    We describe the discovery of a bright, young Kuiper belt–like debris disk around HD 115600, a ∼1.4–1.5 M ⊙ , ∼15 Myr old member of the Sco–Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the Gemini Planet Imager shows the ring has a (luminosity-scaled) semimajor axis of (∼22 AU) ∼ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral-scattering dust, is eccentric (e ∼ 0.1–0.2), and could be sculpted by analogs to the outer solar system planets. Spectroscopy of the disk ansae reveal a slightly blue to gray disk color, consistent with major Kuiper belt chemical constituents, where water ice is a very plausible dominant constituent. Besides being the first object discovered with the next generation of extreme adaptive optics systems (i.e., SCExAO, GPI, SPHERE), HD 115600's debris ring and planetary system provide a key reference point for the early evolution of the solar system, the structure, and composition of the Kuiper belt and the interaction between debris disks and planets

  13. DIRECT IMAGING AND SPECTROSCOPY OF A YOUNG EXTRASOLAR KUIPER BELT IN THE NEAREST OB ASSOCIATION

    Energy Technology Data Exchange (ETDEWEB)

    Currie, Thayne [National Astronomical Observatory of Japan, Subaru Telescope, Hilo, HI (United States); Lisse, Carey M. [Applied Physics Laboratory, The Johns Hopkins University, Laurel, MD (United States); Kuchner, Marc [NASA Goddard Space Flight Center, Greenbelt, MD (United States); Madhusudhan, Nikku [Institute for Astronomy, University of Cambridge, Cambridge (United Kingdom); Kenyon, Scott J. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Thalmann, Christian [ETH-Zurich, Zurich (Switzerland); Carson, Joseph [Department of Physics and Astronomy, The College of Charleston, Charleston, SC (United States); Debes, John [Space Telescope Science Institute, Baltimore, MD (United States)

    2015-07-01

    We describe the discovery of a bright, young Kuiper belt–like debris disk around HD 115600, a ∼1.4–1.5 M{sub ⊙}, ∼15 Myr old member of the Sco–Cen OB Association. Our H-band coronagraphy/integral field spectroscopy from the Gemini Planet Imager shows the ring has a (luminosity-scaled) semimajor axis of (∼22 AU) ∼ 48 AU, similar to the current Kuiper belt. The disk appears to have neutral-scattering dust, is eccentric (e ∼ 0.1–0.2), and could be sculpted by analogs to the outer solar system planets. Spectroscopy of the disk ansae reveal a slightly blue to gray disk color, consistent with major Kuiper belt chemical constituents, where water ice is a very plausible dominant constituent. Besides being the first object discovered with the next generation of extreme adaptive optics systems (i.e., SCExAO, GPI, SPHERE), HD 115600's debris ring and planetary system provide a key reference point for the early evolution of the solar system, the structure, and composition of the Kuiper belt and the interaction between debris disks and planets.

  14. Right upper quadrant pain

    International Nuclear Information System (INIS)

    Ralls, P.W.; Colletti, P.M.; Boswell, W.D. Jr.; Halls, J.M.

    1984-01-01

    Historically, assessment of acute right upper quadrant abdominal pain has been a considerable clinical challenge. While clinical findings and laboratory data frequently narrow the differential diagnosis, symptom overlap generally precludes definitive diagnosis among the various diseases causing acute right upper quadrant pain. Fortunately, the advent of newer diagnostic imaging modalities has greatly improved the rapidity and reliability of diagnosis in these patients. An additional challenge to the physician, with increased awareness of the importance of cost effectiveness in medicine, is to select appropriate diagnostic schema that rapidly establish accurate diagnoses in the most economical fashion possible. The dual goals of this discussion are to assess not only the accuracy of techniques used to evaluate patients with acute right upper quadrant pain, but also to seek out cost-effective, coordinated imaging techniques to achieve this goal

  15. As assessment of the flux of radionuclide contamination through the Ob and Yenisei rivers and estuaries to the Kara Sea

    International Nuclear Information System (INIS)

    Pauluszkiewicz, T.; Hibler, L.F.; Richmond, M.C.; Bradley, D.J.

    1995-01-01

    Recent data indicate that there are potentially large sources of radionuclide contamination on the Ob River system. To quantify the existing radionuclide contamination from a possible catastrophic event data and models have been used to quantify scenarios. Using a compilation of Russian data on the radionuclide contamination, hydrologic data and studies on the sediment transport process a conceptual model has been developed of the Ob system, and a numerical model has been applied to estimate the radionuclide flux to the Kara Sea. The initial results of the river modeling in the Mayak region show how important watershed flow from the marshes are to the hydrologic budget of the area. The preliminary analysis of the sediment flux indicates the need to consider the depositional (storage) regions such as the Asanow Marsh. 31 refs., 5 figs

  16. Growth of yttrium iron garnet single crystals in Na2O-B2O3 flux system in air

    International Nuclear Information System (INIS)

    Bandyopadhyay, Tarun; Saha, Prasenjit

    1977-01-01

    Detailed studies of growth of yttrium iron garnet (YIG) in the flux system Na 2 O-B 2 O 3 were made to delineate the phase stability regions of YIG and the neighbouring crystalline phases, and a tentative working diagram of Na 2 O-B 2 O 3 -YIG in air was drawn from the results of small batch crystal growth runs and solubility studies. The occurrence of a rather narrow field of YIG crystallization in this system was explained on the basis of relative solubilities of different oxides constituting YIG. Several long-time growth runs with some typical compositions were carried out in this system to evaluate its suitability for bulk growth of YIG crystals. The system, although possessing some inherent advantages, was found to suffer from limitations because the maximum size of the self-nucleated crystals grown hardly exceeded 2.00 mm. (author)

  17. Réduire l'obésité chez les enfants au Mexique | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    27 avr. 2016 ... ... le Mexique connaît une « transition nutritionnelle » sous l'effet des changements qui se sont produits en ce qui concerne le régime alimentaire, la nutrition et l'activité physique. Le surpoids et l'obésité sont des facteurs de risque pour les maladies chroniques comme le diabète et le cancer, sans compter ...

  18. De la ferme à la fourchette – lutte contre l'obésité chez les enfants ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    26 avr. 2016 ... ... but de combattre l'obésité chez les enfants. La démarche repose sur trois piliers, à savoir augmenter la proportion de fruits et de légumes frais dans les repas servis à l'école, faciliter l'approvisionnement en produits auprès des agriculteurs locaux et favoriser l'augmentation de la production maraîchère.

  19. Adipokines : rôle dans l’obésité et l’insulino‐résistance

    Directory of Open Access Journals (Sweden)

    Aubert Roberte

    2003-03-01

    Full Text Available Le tissu adipeux longtemps considéré comme un organe de stockage est maintenant reconnu comme un organe endocrine. Cette revue étudie l’action de 3 adipokines sécrétées par le tissu adipeux et impliquées dans le contrôle de l’homéostasie énergétique et l’insulino‐résistance, la leptine, l’adiponectine et la résistine. La découverte de la leptine a permis la compréhension des mécanismes centraux de la prise alimentaire et de la dépense énergétique. L’espoir que la leptine puisse intervenir dans le traitement de l’obésité a été déçu, mais elle joue un rôle important dans l’insulino‐sensibilité. L’adiponectine circulante est diminuée dans l’obésité et la perte pondérale augmente son taux. Elle améliore la sensibilité à l’insuline en agissant sur le métabolisme glucidique et lipidique. Bien que pour le moment le rôle de la résistine soit encore mal défini, les études chez l’animal suggèrent qu’elle soit impliqués dans l’insulino‐résistance. Chez l’homme il n’y a pas de relation entre l’expression de la résistine et l’obésité. On peut donc se demander si la résistine, dans l’espèce humaine, est bien le lien entre obésité et diabète de type 2.

  20. Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7

    Energy Technology Data Exchange (ETDEWEB)

    Duggirala, R.; Stern, M.P.; Reinhart, L.J. [Univ. of Texas Health Science Center, San Antonio, TX (United States)] [and others

    1996-09-01

    Despite the evidence that human obesity has strong genetic determinants, efforts at identifying specific genes that influence human obesity have largely been unsuccessful. Using the sibship data obtained from 32 low-income Mexican American pedigrees ascertained on a type II diabetic proband and a multipoint variance-components method, we tested for linkage between various obesity-related traits plus associated metabolic traits and 15 markers on human chromosome 7. We found evidence for linkage between markers in the OB gene region and various traits, as follows: D7S514 and extremity skinfolds (LOD = 3.1), human carboxypeptidase A1 (HCPA1) and 32,33-split proinsulin level (LOD = 4.2), and HCPA1 and proinsulin level (LOD = 3.2). A putative susceptibility locus linked to the marker D7S514 explained 56% of the total phenotypic variation in extremity skinfolds. Variation at the HCPA1 locus explained 64% of phenotypic variation in proinsulin level and {approximately}73% of phenotypic variation in split proinsulin concentration, respectively. Weaker evidence for linkage to several other obesity-related traits (e.g., waist circumference, body-mass index, fat mass by bioimpedance, etc.) was observed for a genetic location, which is {approximately}15 cM telomeric to OB. In conclusion, our study reveals that the OB region plays a significant role in determining the phenotypic variation of both insulin precursors and obesity-related traits, at least in Mexican Americans. 66 refs., 3 figs., 4 tabs.

  1. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    International Nuclear Information System (INIS)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas; Gutermuth, Robert A.; Pipher, Judith L.; Naylor, Tim; Jeffries, R. D.

    2014-01-01

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K s photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R V = 3.1 and R V = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A V is investigated and we find the extinction law becomes shallower for regions with A V > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  2. An anomalous extinction law in the Cep OB3b young cluster: Evidence for dust processing during gas dispersal

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Thomas S.; Prchlik, Jakub J.; Megeath, S. Thomas [University of Toledo, Ritter Astrophysical Observatory, Department of Physics and Astronomy, Toledo, OH 43606 (United States); Gutermuth, Robert A. [Five College Astronomy Department, Smith College, Northampton, MA 01063 (United States); Pipher, Judith L. [Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627 (United States); Naylor, Tim [School of Physics, University of Exeter, Exeter, UK EX4 4QL (United Kingdom); Jeffries, R. D. [Astrophysics Group, School of Physical and Geographical Sciences, Keele University, Keele, Staffordshire, UK ST5 5BG (United Kingdom)

    2014-05-10

    We determine the extinction law through Cep OB3b, a young cluster of 3000 stars undergoing gas dispersal. The extinction is measured toward 76 background K giants identified with MMT/Hectospec spectra. Color excess ratios were determined toward each of the giants using V and R photometry from the literature, g, r, i, and z photometry from the Sloan Digital Sky Survey and J, H, and K{sub s} photometry from the Two Micron All Sky Survey. These color excess ratios were then used to construct the extinction law through the dusty material associated with Cep OB3b. The extinction law through Cep OB3b is intermediate between the R{sub V} = 3.1 and R{sub V} = 5 laws commonly used for the diffuse atomic interstellar medium and dense molecular clouds, respectively. The dependence of the extinction law on line-of-sight A{sub V} is investigated and we find the extinction law becomes shallower for regions with A{sub V} > 2.5 mag. We speculate that the intermediate dust law results from dust processing during the dispersal of the molecular cloud by the cluster.

  3. Comparison of the biometric measurements calculated with Zeiss IOL-Master and WaveLight OB-820

    Directory of Open Access Journals (Sweden)

    Labiris G

    2017-04-01

    Full Text Available Georgios Labiris,1,2 Panagiota Ntonti,2 Konstantinos Ntitsos,2 Andreas Katsanos,2 Haris Sideroudi,2 Vasilios Kozobolis1,2 1Department of Ophthalmology, University Hospital of Alexandroupolis, 2Eye Institute of Thrace, Alexandroupolis, Greece Background: The primary objective of this study was to investigate the level of agreement between IOL-Master and OB-820 ocular biometers.Materials and methods: In this prospective randomized case series, we measured the anterior chamber depth (ACD, the axial length (AL, the corneal radii (R1, R2, the ratio of mean corneal radius and spherical equivalent and the corneal astigmatism (cylinder [Cyl] before and after cataract extraction surgery.Results: Significant differences between pre- and postoperative data were observed for ACD for both biometric devices (P<0.01 and Cyl parameter in IOL-Master. Range and 95% limits of agreement (LoA were clinically significantly different for AL parameter pre- and postoperatively and for R2 and radius and spherical equivalent postoperatively (P<0.001. The rest of the parameters presented sufficient 95% LoA, which imply good agreement.Conclusion: In clinical practice, the IOL-master and OB-820 should not be used interchangeably due to discrepancy in the important AL parameter. Both biometers may provide consistent results regarding Cyl, ACD and R1. Keywords: cataract, IOL-Master, OB-820, biometry, level of agreement

  4. Upper airway evaluation

    International Nuclear Information System (INIS)

    Hoffman, E.A.; Gefter, W.B.; Schnall, M.; Nordberg, J.; Listerud, J.; Lenkinski, R.E.

    1988-01-01

    The authors are evaluating upper-airway sleep disorders with magnetic resonance (MR) imaging and x-ray cine computed tomography (CT). Fixed structural anatomy is visualized with multisection spin-echo MR imaging, the dynamic component with cine CT. Unique aspects of the study are described in this paper

  5. CARINA OB STARS: X-RAY SIGNATURES OF WIND SHOCKS AND MAGNETIC FIELDS

    International Nuclear Information System (INIS)

    Gagne, Marc; Fehon, Garrett; Savoy, Michael R.; Cohen, David H.; Townsley, Leisa K.; Broos, Patrick S.; Povich, Matthew S.; Corcoran, Michael F.; Walborn, Nolan R.; Remage Evans, Nancy; Moffat, Anthony F. J.; Naze, Yael; Oskinova, Lida M.

    2011-01-01

    The Chandra Carina Complex contains 200 known O- and B-type stars. The Chandra survey detected 68 of the 70 O stars and 61 of 127 known B0-B3 stars. We have assembled a publicly available optical/X-ray database to identify OB stars that depart from the canonical L X /L bol relation or whose average X-ray temperatures exceed 1 keV. Among the single O stars with high kT we identify two candidate magnetically confined wind shock sources: Tr16-22, O8.5 V, and LS 1865, O8.5 V((f)). The O4 III(fc) star HD 93250 exhibits strong, hard, variable X-rays, suggesting that it may be a massive binary with a period of >30 days. The visual O2 If* binary HD 93129A shows soft 0.6 keV and hard 1.9 keV emission components, suggesting embedded wind shocks close to the O2 If* Aa primary and colliding wind shocks between Aa and Ab. Of the 11 known O-type spectroscopic binaries, the long orbital-period systems HD 93343, HD 93403, and QZ Car have higher shock temperatures than short-period systems such as HD 93205 and FO 15. Although the X-rays from most B stars may be produced in the coronae of unseen, low-mass pre-main-sequence companions, a dozen B stars with high L X cannot be explained by a distribution of unseen companions. One of these, SS73 24 in the Treasure Chest cluster, is a new candidate Herbig Be star.

  6. Seismic velocity variation along the Izu-Bonin arc estaimated from traveltime tomography using OBS data

    Science.gov (United States)

    Obana, K.; Tamura, Y.; Takahashi, T.; Kodaira, S.

    2014-12-01

    The Izu-Bonin (Ogasawara) arc is an intra-oceanic island arc along the convergent plate boundary between the subducting Pacific and overriding Philippine Sea plates. Recent active seismic studies in the Izu-Bonin arc reveal significant along-arc variations in crustal structure [Kodaira et al., 2007]. The thickness of the arc crust shows a remarkable change between thicker Izu (~30 km) and thinner Bonin (~10 km) arcs. In addition to this, several geological and geophysical contrasts, such as seafloor topography and chemical composition of volcanic rocks, between Izu and Bonin arc have been reported [e.g., Yuasa 1992]. We have conducted earthquake observations using ocean bottom seismographs (OBSs) to reveal seismic velocity structure of the crust and mantle wedge in the Izu-Bonin arc and to investigate origin of the along-arc structure variations. We deployed 40 short-period OBSs in Izu and Bonin area in 2006 and 2009, respectively. The OBS data were processed with seismic data recorded at routine seismic stations on Hachijo-jima, Aoga-shima, and Chichi-jima operated by National Research Institute for Earth Science and Disaster Prevention (NIED). More than 5000 earthquakes were observed during about three-months observation period in each experiment. We conducted three-dimensional seismic tomography using manually picked P- and S-wave arrival time data. The obtained image shows a different seismic velocity structures in the mantle beneath the volcanic front between Izu and Bonin arcs. Low P-wave velocity anomalies in the mantle beneath the volcanic front in the Izu arc are limited at depths deeper than those in the Bonin arc. On the other hand, P-wave velocity in the low velocity anomalies beneath volcanic front in the Bonin arc is slower than that in the Izu arc. These large-scale along-arc structure variations in the mantle could relate to the geological and geophysical contrasts between Izu and Bonin arcs.

  7. NEAR-INFRARED VARIABILITY AMONG YOUNG STELLAR OBJECTS IN THE STAR FORMATION REGION CYGNUS OB7

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, Scott J.; Rice, Thomas S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin [Institute for Astronomy, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2013-08-20

    We present an analysis of near-infrared time-series photometry in J, H, and K bands for about 100 epochs of a 1 Degree-Sign Multiplication-Sign 1 Degree-Sign region of the Lynds 1003/1004 dark cloud in the Cygnus OB7 region. Augmented by data from the Wide-field Infrared Survey Explorer, we identify 96 candidate disk bearing young stellar objects (YSOs) in the region. Of these, 30 are clearly Class I or earlier. Using the Wide-Field Imaging Camera on the United Kingdom Infrared Telescope, we were able to obtain photometry over three observing seasons, with photometric uncertainty better than 0.05 mag down to J Almost-Equal-To 17. We study detailed light curves and color trajectories of {approx}50 of the YSOs in the monitored field. We investigate the variability and periodicity of the YSOs and find the data are consistent with all YSOs being variable in these wavelengths on timescales of a few years. We divide the variability into four observational classes: (1) stars with periodic variability stable over long timescales, (2) variables which exhibit short-lived cyclic behavior, (3) long-duration variables, and (4) stochastic variables. Some YSO variability defies simple classification. We can explain much of the observed variability as being due to dynamic and rotational changes in the disk, including an asymmetric or changing blocking fraction, changes to the inner disk hole size, as well as changes to the accretion rate. Overall, we find that the Class I:Class II ratio of the cluster is consistent with an age of <1 Myr, with at least one individual, wildly varying source {approx}100, 000 yr old. We have also discovered a Class II eclipsing binary system with a period of 17.87 days.

  8. FITspec: A New Algorithm for the Automated Fit of Synthetic Stellar Spectra for OB Stars

    Science.gov (United States)

    Fierro-Santillán, Celia R.; Zsargó, Janos; Klapp, Jaime; Díaz-Azuara, Santiago A.; Arrieta, Anabel; Arias, Lorena; Sigalotti, Leonardo Di G.

    2018-06-01

    In this paper we describe the FITspec code, a data mining tool for the automatic fitting of synthetic stellar spectra. The program uses a database of 27,000 CMFGEN models of stellar atmospheres arranged in a six-dimensional (6D) space, where each dimension corresponds to one model parameter. From these models a library of 2,835,000 synthetic spectra were generated covering the ultraviolet, optical, and infrared regions of the electromagnetic spectrum. Using FITspec we adjust the effective temperature and the surface gravity. From the 6D array we also get the luminosity, the metallicity, and three parameters for the stellar wind: the terminal velocity ({v}∞ ), the β exponent of the velocity law, and the clumping filling factor (F cl). Finally, the projected rotational velocity (v\\cdot \\sin i) can be obtained from the library of stellar spectra. Validation of the algorithm was performed by analyzing the spectra of a sample of eight O-type stars taken from the IACOB spectroscopic survey of Northern Galactic OB stars. The spectral lines used for the adjustment of the analyzed stars are reproduced with good accuracy. In particular, the effective temperatures calculated with the FITspec are in good agreement with those derived from spectral type and other calibrations for the same stars. The stellar luminosities and projected rotational velocities are also in good agreement with previous quantitative spectroscopic analyses in the literature. An important advantage of FITspec over traditional codes is that the time required for spectral analyses is reduced from months to a few hours.

  9. Preparedness of Ob/Gyn residents for fellowship training in gynecologic oncology

    Directory of Open Access Journals (Sweden)

    David W. Doo

    2015-04-01

    Full Text Available Residency training in obstetrics and gynecology is being challenged by increasingly stringent regulations and decreased operative experience. We sought to determine the perception of preparedness of incoming gynecologic oncology fellows for advanced surgical training in gynecologic oncology. An online survey was sent to gynecologic oncologists involved in fellowship training in the United States. They were asked to evaluate their most recent incoming clinical fellows in the domains of professionalism, level of independence/graduated responsibility, psychomotor ability, clinical evaluation and management, and academia and scholarship using a standard Likert-style scale. The response rate among attending physicians was 40% (n = 105/260 and 61% (n = 28/46 for program directors. Of those who participated, 49% reported that their incoming fellows could not independently perform a hysterectomy, 59% reported that they could not independently perform 30 min of a major procedure, 40% reported that they could not control bleeding, 40% reported that they could not recognize anatomy and tissue planes, and 58% reported that they could not dissect tissue planes. Fellows lacked an understanding of pathophysiology, treatment recommendations, and the ability to identify and treat critically ill patients. In the academic domain, respondents agreed that fellows were deficient in the areas of protocol design (54%, statistical analysis (54%, and manuscript writing (65%. These results suggest that general Ob/Gyn residency is ineffective in preparing fellows for advanced training in gynecologic oncology and should prompt a revision of the goals and objectives of resident education to correct these deficiencies.

  10. Identificarea izolatului bacterian P5 obţinut din plante de măr

    Directory of Open Access Journals (Sweden)

    MAGHER Maria

    2016-06-01

    Full Text Available The phytopathogen Erwinia amylovora (Burrill Winslow et al. is a bacterium having a major impact on pome fruit species causing identification problems at some development phenophases of trees. The aim of this paper was to identify the bacterial isolate P5 obtained from apple tree samples using classical and modern methods recommended for the bacterium E. amylovora (API 20E test, gas chromatography, PCR, DASELISA and indirect immunofluorescence. As a result of our investigations, the bacterium Erwinia amylovora was clearly identified. Taking into consideration the quarantine status of the phytopathogen E. amylovora, it is necessary to carry out the phytosanitary test sin order to monitor the presence of fire blight on pome fruit species as well as to implement timely the required preventive and curative control measures. Rezumat. Fitopatogenul Erwinia amylovora (Burrill Winslow et al. este o bacterie cu un impact deosebit asupra speciilor pomicole sămânţoase, care prezintă probleme de identificare la anumite fenofaze de dezvoltare a pomilor. Scopul acestei lucrări a fost de a identifica izolatul bacterian P5, obţinut din probe de măr, prin metode clasice şi contemporane recomandate pentru bacteria E. amylovora (testul API 20E, gaz-cromatografie, PCR, DAS-ELISA, imunofluorescenţă indirectă. În rezultatul cercetărilor a fost identificată bacteria Erwinia amylovora. Având în vedere statutul de carantină al fitopatogenului E. amylovora, se impune necesitatea efectuării obligatorii a sondajelor fitosanitare pentru monitorizarea prezenţei focului bacterian la culturile pomicole sămânţoase şi efectuarea la timp a măsurilor preventive şi curative de combatere.

  11. Upper urinary tract tumors

    DEFF Research Database (Denmark)

    Gandrup, Karen L; Nordling, Jørgen; Balslev, Ingegerd

    2014-01-01

    BACKGROUND: Computed tomography urography (CTU) is used widely in the work-up of patients with symptoms of urinary tract lesions. Preoperative knowledge of whether a tumor is invasive or non-invasive is important for the choice of surgery. So far there are no studies about the distinction...... of invasive and non-invasive tumors in ureter and renal pelvis based on the enhancement measured with Hounsfield Units. PURPOSE: To examine the value of CTU using split-bolus technique to distinguish non-invasive from invasive urothelial carcinomas in the upper urinary tract. MATERIAL AND METHODS: Patients...... obtained at CTU could distinguish between invasive and non-invasive lesions. No patients had a CTU within the last year before the examination that resulted in surgery. CONCLUSION: A split-bolus CTU cannot distinguish between invasive and non-invasive urothelial tumors in the upper urinary tract...

  12. Expressão do gene da leptina e seu receptor Ob-Rb no parênquima mamário de novilhas leiteiras Leptin and leptin receptor Ob-Rb gene expression in mammary parenchyma of dairy heifers

    Directory of Open Access Journals (Sweden)

    Betina Joyce Lew

    2012-05-01

    Full Text Available Objetivou-se com este trabalho avaliar os efeitos de uma dieta de alto nível de energia e proteína combinada com a aplicação de bST no perfil de expressão dos genes da leptina e de seu receptor Ob-Rb no parênquima mamário de novilhas leiteiras. Foram utilizadas amostras de parênquima mamário de 32 novilhas holandesas distribuídas aleatoriamente em quatro tratamentos (n=8: dieta com alto ou baixo teor de energia e proteína combinada ou não com a aplicação de bST. O delineamento utilizado foi em blocos casualizados com arranjo de tratamentos em esquema fatorial 2 × 2. A extração do RNA total das amostras de tecido foi feita e o nível de expressão gênica foi analisado por qRT-PCR utilizando-se o gene da glicuronidase β como controle, pelo método 2-ΔΔCt. Animais que receberam a dieta com alto conteúdo de energia e proteína apresentaram maior expressão de mRNA de leptina, com aumento de 56%, e menor expressão de mRNA do receptor Ob-Rb, com redução de 18%. Por outro lado, a aplicação de bST resultou em diminuição da expressão do mRNA de leptina e do receptor Ob-Rb em 74% e 23%, respectivamente. Não houve interação entre dieta e aplicação de bST. O aumento na expressão de leptina pode explicar, ao menos em parte, os efeitos negativos da dieta de alta energia e proteína, oferecida no período pré-púbere, sobre a produção de leite de novilhas leiteiras.The objective of this study was to examine the effects of a diet with high level of energy and protein, combined with bST injections, on leptin and leptin-receptor (Ob-Rb gene expression profile in the mammary parenchyma of dairy heifers. Mammary parenchyma samples from 32 Holstein heifers, randomly assigned to one of four treatments (n=8, were utilized: high or low energy and protein diet, with or without bST injection. The experiment was designed in randomized blocks and arranged in a 2 × 2 factorial arrangement. Total RNA was extracted from tissue samples

  13. Increasing the number and signal-to-noise ratio of OBS traces with supervirtual refraction interferometry and free-surface multiples

    KAUST Repository

    Bharadwaj, P.; Wang, X.; Schuster, Gerard T.; McIntosh, K.

    2013-01-01

    The theory of supervirtual interferometry is modified so that free-surface related multiple refractions can be used to enhance the signal-to-noise ratio (SNR) of primary refraction events by a factor proportional to√Ns, where Ns is the number of post-critical sources for a specified refraction multiple. We also show that refraction multiples can be transformed into primary refraction events recorded at virtual hydrophones located between the actual hydrophones. Thus, data recorded by a coarse sampling of ocean bottom seismic (OBS) stations can be transformed, in principle, into a virtual survey with P times more OBS stations, where P is the order of the visible free-surface related multiple refractions. The key assumption is that the refraction arrivals are those of head waves, not pure diving waves. The effectiveness of this method is validated with both synthetic OBS data and an OBS data set recorded offshore from Taiwan. Results show the successful reconstruction of far-offset traces out to a source-receiver offset of 120 km. The primary supervirtual traces increase the number of pickable first arrivals from approximately 1600 to more than 3100 for a subset of the OBS data set where the source is only on one side of the recording stations. In addition, the head waves associated with the first-order free-surface refraction multiples allow for the creation of six new common receiver gathers recorded at virtual OBS station located about half way between the actual OBS stations. This doubles the number of OBS stations compared to the original survey and increases the total number of pickable traces from approximately 1600 to more than 6200. In summary, our results with the OBS data demonstrate that refraction interferometry can sometimes more than quadruple the number of usable traces, increase the source-receiver offsets, fill in the receiver line with a denser distribution of OBS stations, and provide more reliable picking of first arrivals. Apotential liability

  14. Increasing the number and signal-to-noise ratio of OBS traces with supervirtual refraction interferometry and free-surface multiples

    KAUST Repository

    Bharadwaj, P.

    2013-01-10

    The theory of supervirtual interferometry is modified so that free-surface related multiple refractions can be used to enhance the signal-to-noise ratio (SNR) of primary refraction events by a factor proportional to√Ns, where Ns is the number of post-critical sources for a specified refraction multiple. We also show that refraction multiples can be transformed into primary refraction events recorded at virtual hydrophones located between the actual hydrophones. Thus, data recorded by a coarse sampling of ocean bottom seismic (OBS) stations can be transformed, in principle, into a virtual survey with P times more OBS stations, where P is the order of the visible free-surface related multiple refractions. The key assumption is that the refraction arrivals are those of head waves, not pure diving waves. The effectiveness of this method is validated with both synthetic OBS data and an OBS data set recorded offshore from Taiwan. Results show the successful reconstruction of far-offset traces out to a source-receiver offset of 120 km. The primary supervirtual traces increase the number of pickable first arrivals from approximately 1600 to more than 3100 for a subset of the OBS data set where the source is only on one side of the recording stations. In addition, the head waves associated with the first-order free-surface refraction multiples allow for the creation of six new common receiver gathers recorded at virtual OBS station located about half way between the actual OBS stations. This doubles the number of OBS stations compared to the original survey and increases the total number of pickable traces from approximately 1600 to more than 6200. In summary, our results with the OBS data demonstrate that refraction interferometry can sometimes more than quadruple the number of usable traces, increase the source-receiver offsets, fill in the receiver line with a denser distribution of OBS stations, and provide more reliable picking of first arrivals. Apotential liability

  15. Breakup Style and Magmatic Underplating West of the Lofoten Islands, Norway, Based on OBS Data.

    Science.gov (United States)

    Breivik, A. J.; Faleide, J. I.; Mjelde, R.; Murai, Y.; Flueh, E. R.

    2014-12-01

    The breakup of the Northeast Atlantic in the Early Eocene was magma-rich, forming the major part of the North Atlantic Igneous Province (NAIP). This is seen as extrusive and intrusive magmatism in the continental domain, and as a thicker than normal oceanic crust produced the first few million years after continental breakup. The maximum magma productivity and the duration of excess magmatism varies along the margins of Northwest Europe and East Greenland, to some extent as a function of the distance from the Iceland hotspot. The Vøring Plateau off mid-Norway is the northernmost of the margin segments in northwestern Europe with extensive magmatism. North of the plateau, magmatism dies off towards the Lofoten Margin, marking the northern boundary of the NAIP here. In 2003, as part of the Euromargins Program we collected an Ocean Bottom Seismometer (OBS) profile from mainland Norway, across the Lofoten Islands, and out into the deep ocean. Forward velocity modeling using raytracing reveals a continental margin that shows transitional features between magma-rich and magma-poor rifting. On one hand, we detect an up to 2 km thick and 40-50 km wide magmatic underplate of the outer continent, on the other hand, continental thinning is greater and intrusive magmatism less than farther south. Continental breakup also appears to be somewhat delayed compared to breakup on the Vøring Plateau, consistent with increased extension. This indicates that magmatic diking, believed to quickly lead to continental breakup of volcanic margins and thus to reduce continental thinning, played a much lesser role here than at the plateau. Early post-breakup oceanic crust is up to 8 km thick, less than half of that observed farther south. The most likely interpretation of these observations, is that the source for the excess magmatism of the NAIP was not present at the Lofoten Margin during rifting, and that the excess magmatism actually observed was the result of lateral transport from the

  16. NEAR-INFRARED VARIABILITY IN YOUNG STARS IN CYGNUS OB7

    Energy Technology Data Exchange (ETDEWEB)

    Rice, Thomas S. [Department of Astronomy, Harvard University, 60 Garden Street, Cambridge, MA 02138 (United States); Wolk, Scott J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin [Institute for Astronomy, University of Hawaii at Manoa, 640 N Aohoku Pl, Hilo, HI 96720 (United States)

    2012-08-10

    We present the first results from a 124 night J, H, K near-infrared monitoring campaign of the dark cloud L 1003 in Cygnus OB7, an active star-forming region. Using three seasons of UKIRT observations spanning 1.5 years, we obtained high-quality photometry on 9200 stars down to J = 17 mag, with photometric uncertainty better than 0.04 mag. On the basis of near-infrared excesses from disks, we identify 30 pre-main-sequence stars, including 24 which are newly discovered. We analyze those stars and find that the NIR excesses are significantly variable. All 9200 stars were monitored for photometric variability; among the field star population, {approx}160 exhibited near-infrared variability (1.7% of the sample). Of the 30 young stellar objects (YSOs), 28 of them (93%) are variable at a significant level. Of the 30 YSOs, twenty-five have near-infrared excess consistent with simple disk-plus-star classical T Tauri models. Nine of these (36%) drift in color space over the course of these observations and/or since Two Micron All Sky Survey observations such that they cross the boundary defining the NIR excess criteria; effectively, they have a transient near-infrared excess. Thus, time-series JHK observations can be used to obtain a more complete sample of disk-bearing stars than single-epoch JHK observations. About half of the YSOs have color-space variations parallel to either the classical T Tauri star locus or a hybrid track which includes the dust reddening trajectory. This indicates that the NIR variability in YSOs that possess accretion disks arises from a combination of variable extinction and changes in the inner accretion disk: either in accretion rate, central hole size, and/or the inclination of the inner disk. While some variability may be due to stellar rotation, the level of variability on the individual stars can exceed a magnitude. This is a strong empirical suggestion that protoplanetary disks are quite dynamic and exhibit more complex activity on short

  17. Regional and temporal variations in coding of hospital diagnoses referring to upper gastrointestinal and oesophageal bleeding in Germany

    Directory of Open Access Journals (Sweden)

    Garbe Edeltraut

    2011-08-01

    Full Text Available Abstract Background Health insurance claims data are increasingly used for health services research in Germany. Hospital diagnoses in these data are coded according to the International Classification of Diseases, German modification (ICD-10-GM. Due to the historical division into West and East Germany, different coding practices might persist in both former parts. Additionally, the introduction of Diagnosis Related Groups (DRGs in Germany in 2003/2004 might have changed the coding. The aim of this study was to investigate regional and temporal variations in coding of hospitalisation diagnoses in Germany. Methods We analysed hospitalisation diagnoses for oesophageal bleeding (OB and upper gastrointestinal bleeding (UGIB from the official German Hospital Statistics provided by the Federal Statistical Office. Bleeding diagnoses were classified as "specific" (origin of bleeding provided or "unspecific" (origin of bleeding not provided coding. We studied regional (former East versus West Germany differences in incidence of hospitalisations with specific or unspecific coding for OB and UGIB and temporal variations between 2000 and 2005. For each year, incidence ratios of hospitalisations for former East versus West Germany were estimated with log-linear regression models adjusting for age, gender and population density. Results Significant differences in specific and unspecific coding between East and West Germany and over time were found for both, OB and UGIB hospitalisation diagnoses, respectively. For example in 2002, incidence ratios of hospitalisations for East versus West Germany were 1.24 (95% CI 1.16-1.32 for specific and 0.67 (95% CI 0.60-0.74 for unspecific OB diagnoses and 1.43 (95% CI 1.36-1.51 for specific and 0.83 (95% CI 0.80-0.87 for unspecific UGIB. Regional differences nearly disappeared and time trends were less marked when using combined specific and unspecific diagnoses of OB or UGIB, respectively. Conclusions During the study

  18. OB/GYN boot cAMP using high-fidelity human simulators: enhancing residents' perceived competency, confidence in taking a leadership role, and stress hardiness.

    Science.gov (United States)

    Pliego, Jose F; Wehbe-Janek, Hania; Rajab, M Hasan; Browning, Jeff L; Fothergill, Russell E

    2008-01-01

    To evaluate the effectiveness of an obstetrical and gynecologic (Ob/Gyn) Boot Camp simulation training on perceived technical competency, confidence in a leadership role, and stress hardiness of resident training. We conducted a prospective pilot study on the effectiveness of an Ob/Gyn Boot Camp on resident training. Residents participated in an intensive immersion in clinical simulation of common obstetrical emergencies including shoulder dystocia, neonatal resuscitation, postpartum hemorrhage, and ruptured ectopic pregnancy. After the training, residents completed a Web-based survey on their perceptions of how the Ob/Gyn Boot Camp affected their 1) technical competency in the assessment and management of their patients, 2) confidence in taking a leadership role, and 3) stress hardiness. Residents rated their perceptions on a Likert scale of 1 to 5, 1 = poor to 5 = excellent. Twenty-three (14 Ob/Gyn and 9 family medicine) residents participated in this pilot study. Eighteen (78%) residents completed the online survey; 4 Ob/Gyn and 1 family medicine resident did not complete the survey. The residents reported that the simulation training stimulated an interest in learning key skills for obstetrical and gynecologic emergencies. Ob/Gyn residents reported significant improvement in their perceived technical competence and stress hardiness after the Boot Camp. However both Ob/Gyn and family medicine residents reported no significant improvement of confidence in their leadership abilities during obstetrical emergencies after the Boot Camp. Boot Camp simulation training early in the curriculum has the potential for enhancing residents' self-assessments of confidence, competency, and stress hardiness in managing obstetrical emergencies.

  19. Molecular Gas toward the Gemini OB1 Molecular Cloud Complex. II. CO Outflow Candidates with Possible WISE Associations

    Science.gov (United States)

    Li, Yingjie; Li, Fa-Cheng; Xu, Ye; Wang, Chen; Du, Xin-Yu; Yang, Wenjin; Yang, Ji

    2018-03-01

    We present a large-scale survey of CO outflows in the Gem OB1 molecular cloud complex and its surroundings, using the Purple Mountain Observatory Delingha 13.7 m telescope. A total of 198 outflow candidates were identified over a large area (∼58.5 square degrees), of which 193 are newly detected. Approximately 68% (134/198) are associated with the Gem OB1 molecular cloud complex, including clouds GGMC 1, GGMC 2, BFS 52, GGMC 3, and GGMC 4. Other regions studied are: the Local arm (Local Lynds, West Front), Swallow, Horn, and Remote cloud. Outflow candidates in GGMC 1, BFS 52, and Swallow are mainly located at ring-like or filamentary structures. To avoid excessive uncertainty in distant regions (≳3.8 kpc), we only estimated the physical parameters for clouds in the Gem OB1 molecular cloud complex and in the Local arm. In those clouds, the total kinetic energy and the energy injection rate of the identified outflow candidates are ≲1% and ≲3% of the turbulent energy and the turbulent dissipation rate of each cloud, indicating that the identified outflow candidates cannot provide enough energy to balance turbulence of their host cloud at the scale of the entire cloud (several to dozens of parsecs). The gravitational binding energy of each cloud is ≳135 times the total kinetic energy of the identified outflow candidates within the corresponding cloud, indicating that the identified outflow candidates cannot cause major disruptions to the integrity of their host cloud at the scale of the entire cloud.

  20. in upper gastrointestinal endoscopy

    Directory of Open Access Journals (Sweden)

    Sinan Uzman

    2016-07-01

    Full Text Available Introduction : There is increasing interest in sedation for upper gastrointestinal endoscopy (UGE. Prospective randomized studies comparing sedation properties and complications of propofol and midazolam/meperidine in upper gastrointestinal endoscopy (UGE are few. Aim: To compare propofol and midazolam/meperidine sedation for UGE in terms of cardiopulmonary side effects, patient and endoscopist satisfaction and procedure-related times. Material and methods: This was a prospective, randomized, double-blind study of propofol versus midazolam and meperidine in 100 patients scheduled for diagnostic upper gastrointestinal endoscopy. The patients were divided into propofol and midazolam/meperidine groups. Randomization was generated by a computer. Cardiopulmonary side effects (hypotension, bradycardia, hypoxemia, procedure-related times (endoscopy time, awake time, time to hospital discharge, and patient and endoscopist satisfaction were compared between groups. Results: There was no significant difference between the groups with respect to the cost, endoscopy time, or demographic and clinical characteristics of the patients. Awake time and time to hospital discharge were significantly shorter in the propofol group (6.58 ±4.72 vs. 9.32 ±4.26 min, p = 0.030 and 27.60 ±7.88 vs. 32.00 ±10.54 min, p = 0.019. Hypotension incidence was significantly higher in the propofol group (12% vs. 0%, p = 0.027. The patient and endoscopist satisfaction was better with propofol. Conclusions : Propofol may be preferred to midazolam/meperidine sedation, with a shorter awake and hospital discharge time and better patient and endoscopist satisfaction. However, hypotension risk should be considered with propofol, and careful evaluation is needed, particularly in cardiopulmonary disorders.

  1. THE MASSIVE STAR-FORMING REGION CYGNUS OB2. II. INTEGRATED STELLAR PROPERTIES AND THE STAR FORMATION HISTORY

    International Nuclear Information System (INIS)

    Wright, N. J.; Drake, J. J.; Drew, J. E.; Vink, J. S.

    2010-01-01

    Cygnus OB2 is the nearest example of a massive star-forming region (SFR), containing over 50 O-type stars and hundreds of B-type stars. We have analyzed the properties of young stars in two fields in Cyg OB2 using the recently published deep catalog of Chandra X-ray point sources with complementary optical and near-IR photometry. Our sample is complete to ∼1 M sun (excluding A- and B-type stars that do not emit X-rays), making this the deepest study of the stellar properties and star formation history in Cyg OB2 to date. From Siess et al. isochrone fits to the near-IR color-magnitude diagram, we derive ages of 3.5 +0.75 -1.0 and 5.25 +1.5 -1.0 Myr for sources in the two fields, both with considerable spreads around the pre-main-sequence isochrones. The presence of a stellar population somewhat older than the present-day O-type stars, also fits in with the low fraction of sources with inner circumstellar disks (as traced by the K-band excess) that we find to be very low, but appropriate for a population of age ∼5 Myr. We also find that the region lacks a population of highly embedded sources that is often observed in young SFRs, suggesting star formation in the vicinity has declined. We measure the stellar mass functions (MFs) in this limit and find a power-law slope of Γ = -1.09 ± 0.13, in good agreement with the global mean value estimated by Kroupa. A steepening of the slope at higher masses is observed and suggested as due to the presence of the previous generation of stars that have lost their most massive members. Finally, combining our MF and an estimate of the radial density profile of the association suggests a total mass of Cyg OB2 of ∼3 x 10 4 M sun , similar to that of many of our Galaxy's most massive SFRs.

  2. Search for OB stars running away from young star clusters. II. The NGC 6357 star-forming region

    Science.gov (United States)

    Gvaramadze, V. V.; Kniazev, A. Y.; Kroupa, P.; Oh, S.

    2011-11-01

    Dynamical few-body encounters in the dense cores of young massive star clusters are responsible for the loss of a significant fraction of their massive stellar content. Some of the escaping (runaway) stars move through the ambient medium supersonically and can be revealed via detection of their bow shocks (visible in the infrared, optical or radio). In this paper, which is the second of a series of papers devoted to the search for OB stars running away from young ( ≲ several Myr) Galactic clusters and OB associations, we present the results of the search for bow shocks around the star-forming region NGC 6357. Using the archival data of the Midcourse Space Experiment (MSX) satellite and the Spitzer Space Telescope, and the preliminary data release of the Wide-Field Infrared Survey Explorer (WISE), we discovered seven bow shocks, whose geometry is consistent with the possibility that they are generated by stars expelled from the young (~1-2 Myr) star clusters, Pismis 24 and AH03 J1725-34.4, associated with NGC 6357. Two of the seven bow shocks are driven by the already known OB stars, HD 319881 and [N78] 34. Follow-up spectroscopy of three other bow-shock-producing stars showed that they are massive (O-type) stars as well, while the 2MASS photometry of the remaining two stars suggests that they could be B0 V stars, provided that both are located at the same distance as NGC 6357. Detection of numerous massive stars ejected from the very young clusters is consistent with the theoretical expectation that star clusters can effectively lose massive stars at the very beginning of their dynamical evolution (long before the second mechanism for production of runaway stars, based on a supernova explosion in a massive tight binary system, begins to operate) and lends strong support to the idea that probably all field OB stars have been dynamically ejected from their birth clusters. A by-product of our search for bow shocks around NGC 6357 is the detection of three circular

  3. Spodbujanje ustvarjalnosti v poletnih počitniških varstvih, sofinanciranih s strani Mestne občine Ljubljana

    OpenAIRE

    Grm, Urša

    2017-01-01

    Spodbujanje ustvarjalnosti skozi umetnost ima ključni pomen pri snovanju novih in različnih idej, izražanju domišljije, kakovostnem preživljanju časa ter izboljšanju kakovosti življenja (Knoll, 2011). Aktivira otrokove intelektualne, čustvene in motivacijske procese (Kroflič in Gobec, 1995). H kakovostnemu preživljanju časa poletnih počitnic prispeva Mestna občina Ljubljana (MOL), ki sofinancira prostočasne in preventivne programe za otroke od 1.–5. razreda osnovne šole s stalnim prebivališče...

  4. More accurate definition of liquation dome in Na2O-B2O3-SiO2 system

    International Nuclear Information System (INIS)

    Alekseeva, Z.D.; Mazurin, O.V.; Aver'yanov, V.I.; Galakhov, F.Ya.

    1977-01-01

    The liquation region in the system Na 2 O-B 2 O 3 -SiO 2 was investigated. The liquation temperatures were determined by the boundary of disappearance of opalescence in specimens with pre-induced opalescence. Extrapolation of the concentration dependences of the liquation temperature along sections with a constant SiO 2 content to a point indicates that with a SiO 2 content of 20-40% the liquation boundary in the system B 2 O 3 -SiO 2 hardly lies above 450 deg C

  5. Globules and pillars in Cygnus X. I. Herschel far-infrared imaging of the Cygnus OB2 environment

    Science.gov (United States)

    Schneider, N.; Bontemps, S.; Motte, F.; Blazere, A.; André, Ph.; Anderson, L. D.; Arzoumanian, D.; Comerón, F.; Didelon, P.; Di Francesco, J.; Duarte-Cabral, A.; Guarcello, M. G.; Hennemann, M.; Hill, T.; Könyves, V.; Marston, A.; Minier, V.; Rygl, K. L. J.; Röllig, M.; Roy, A.; Spinoglio, L.; Tremblin, P.; White, G. J.; Wright, N. J.

    2016-06-01

    The radiative feedback of massive stars on molecular clouds creates pillars, globules and other features at the interface between the H II region and molecular cloud. Optical and near-infrared observations from the ground as well as with the Hubble or Spitzer satellites have revealed numerous examples of such cloud structures. We present here Herschel far-infrared observations between 70 μm and 500 μm of the immediate environment of the rich Cygnus OB2 association, performed within the Herschel imaging survey of OB Young Stellar objects (HOBYS) program. All of the observed irradiated structures were detected based on their appearance at 70 μm, and have been classified as pillars, globules, evaporating gasous globules (EGGs), proplyd-like objects, and condensations. From the 70 μm and 160 μm flux maps, we derive the local far-ultraviolet (FUV) field on the photon dominated surfaces. In parallel, we use a census of the O-stars to estimate the overall FUV-field, that is 103-104 G0 (Habing field) close to the central OB cluster (within 10 pc) and decreases down to a few tens G0, in a distance of 50 pc. From a spectral energy distribution (SED) fit to the four longest Herschel wavelengths, we determine column density and temperature maps and derive masses, volume densities and surface densities for these structures. We find that the morphological classification corresponds to distinct physical properties. Pillars and globules are massive (~500 M⊙) and large (equivalent radius r ~ 0.6 pc) structures, corresponding to what is defined as "clumps" for molecular clouds. EGGs and proplyd-likeobjects are smaller (r ~ 0.1 and 0.2 pc) and less massive (~10 and ~30 M⊙). Cloud condensations are small (~0.1 pc), have an average mass of 35 M⊙, are dense (~6 × 104 cm-3), and can thus be described as molecular cloud "cores". All pillars and globules are oriented toward the Cyg OB2 association center and have the longest estimated photoevaporation lifetimes, a few million

  6. Upper extremity golf injuries.

    Science.gov (United States)

    Cohn, Michael A; Lee, Steven K; Strauss, Eric J

    2013-01-01

    Golf is a global sport enjoyed by an estimated 60 million people around the world. Despite the common misconception that the risk of injury during the play of golf is minimal, golfers are subject to a myriad of potential pathologies. While the majority of injuries in golf are attributable to overuse, acute traumatic injuries can also occur. As the body's direct link to the golf club, the upper extremities are especially prone to injury. A thorough appreciation of the risk factors and patterns of injury will afford accurate diagnosis, treatment, and prevention of further injury.

  7. An overview of US refinery configurations and operations (within western Canada supply orbit) : Who currently uses bitumen and SCO? Just how much heavy oil/bitumen is it possible to accept?

    International Nuclear Information System (INIS)

    Flint, L.

    1997-01-01

    A list of US refiners, names and locations that take relatively major heavy crude oil and synthetic crude oil (SCO) volumes from Western Canada was provided. It was suggested that in the near future, production of Canadian heavy crude will not be constrained by supply limits but rather by refinery process capabilities. An overview of refining capacity and heavy oil processing capacity by PADD in kbpsd was presented. The Northern Tier US States (PADD II, PADD IV and Washington/Oregon in PADD V) constitute a total of 4.4 million bpcd refining capacity at 95 per cent utilization. Of this, about 3.4 million bpcd is in PADD II. Montana in PADD IV is the only area dependent solely on Canadian heavy crude supplies. Main competition for Canadian heavy crude comes from Alaska, Mexico, and Venezuela. 1 tab., 2 figs

  8. The Age of Upper Scorpius from Eclipsing Binaries

    Science.gov (United States)

    David, Trevor; Hillenbrand, Lynne

    2018-01-01

    The Upper Scorpius OB association is the nearest region of recent massive star formation and thus an important benchmark for investigations concerning astrophysical timescales. Classical estimates of the association age based on the kinematics of high-mass members and a Hertzsprung-Russell (H-R) diagram of the full stellar population established an age of 5 Myr. However, recent analyses based on the H-R diagram for intermediate- and high-mass members suggest an older age of 11 Myr. Importantly, the H-R diagram ages of stars in Upper Scorpius (and other clusters of a similar age) are mass-dependent, such that low-mass members appear younger than their high-mass counterparts. Here we report an age that is self-consistent in the mass range of 0.3–5 M⊙, and based on the fundamentally-determined masses and radii of eclipsing binaries (EBs). We present nine EBs in Upper Scorpius, four of which are newly reported here and all of which were discovered from K2 photometry. Joint fitting of the eclipse photometry and radial velocities from newly acquired Keck-I/HIRES spectra yields precise masses and radii for those systems that are spectroscopically double-lined. We identify one of the EB components as a slowly pulsating B-star. We use these EBs to develop an empirical mass-radius relation for pre-main-sequence stars, and to evaluate the predictions of widely-used stellar evolutionary models. Our results are consistent with previous studies that indicate most models underestimate the masses of low-mass stars by tens of percent based on H-R diagram analyses. Models including the effects of magnetic fields produce better agreement between the observed bulk and radiative parameters of these young, low-mass stars. From the orbital elements and photometrically inferred rotation periods, we consider the dynamical states of several binaries and compare with expectations from tidal dissipation theories.

  9. Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

    Directory of Open Access Journals (Sweden)

    Peter E. M. Gibbs

    2016-01-01

    Full Text Available Insulin’s stimulation of glucose uptake by binding to the IRK extracellular domain is compromised in diabetes. We have recently described an unprecedented approach to stimulating glucose uptake. KYCCSRK (P2 peptide, corresponding to the C-terminal segment of hBVR, was effective in binding to and inducing conformational change in the IRK intracellular kinase domain. Although myristoylated P2, made of L-amino acids, was effective in cell culture, its use for animal studies was unsuitable. We developed a peptidase-resistant formulation of the peptide that was efficient in both mice and cell culture systems. The peptide was constructed of D-amino acids, in reverse order, and blocked at both termini. Delivery of the encapsulated peptide to HepG2 and HSKM cells was confirmed by its prolonged effect on stimulation of glucose uptake (>6 h. The peptide improved glucose clearance in both wild-type and Ob/Ob mice; it lowered blood glucose levels and suppressed glucose-stimulated insulin secretion. IRK activity was stimulated in the liver of treated mice and in cultured cells. The peptide potentiated function of IRK’s downstream effector, Akt-GSK3-(α,β axis. Thus, P2-based approach can be used for improving glucose uptake by cells. Also, it allows for screening peptides in vitro and in animal models for treatment of diabetes.

  10. The CIDA-QUEST large-scale survey of Orion OB1: evidence for rapid disk dissipation in a dispersed stellar population.

    Science.gov (United States)

    Briceño, C; Vivas, A K; Calvet, N; Hartmann, L; Pacheco, R; Herrera, D; Romero, L; Berlind, P; Sánchez, G; Snyder, J A; Andrews, P

    2001-01-05

    We are conducting a large-scale, multiepoch, optical photometric survey [Centro de Investigaciones de Astronomia-Quasar Equatorial Survey Team (CIDA-QUEST)] covering about 120 square degrees to identify the young low-mass stars in the Orion OB1 association. We present results for an area of 34 square degrees. Using photometric variability as our main selection criterion, as well as follow-up spectroscopy, we confirmed 168 previously unidentified pre-main sequence stars that are about 0.6 to 0.9 times the mass of the sun (Mo), with ages of about 1 million to 3 million years (Ori OB1b) and about 3 million to 10 million years (Ori OB1a). The low-mass stars are spatially coincident with the high-mass (at least 3 Mo) members of the associations. Indicators of disk accretion such as Halpha emission and near-infrared emission from dusty disks fall sharply from Ori OB1b to Ori OB1a, indicating that the time scale for disk dissipation and possibly the onset of planet formation is a few million years.

  11. Sensitivity analysis of P-waves and S-waves to gas hydrate in the Shenhu area using OBS

    Science.gov (United States)

    Xing, Lei; Liu, Xueqin; Zhang, Jin; Liu, Huaishan; Zhang, Jing; Li, Zizheng; Wang, Jianhua

    2018-02-01

    Compared to towed streamers, ocean-bottom seismometers (OBS) obtain both S-wave data and richer wavefield information. In this paper, the induced polarization method is used to conduct wavefield separation on OBS data obtained from the Shenhu area in the South China Sea. A comparison of the changes in P- and S-waves, and a comprehensive analysis of geological factors within the area, enable analysis and description of the occurrence of natural gas hydrate in the study area. Results show an increase in P-wave velocity when natural gas hydrate exists in the formation, whereas the S-wave velocity remains almost constant, as S-waves can only propagate through the rock skeleton. Therefore, the bottom-simulating reflection (BSR) response of the P-wave is better than that of the S-wave in the frequency analysis profile. In a wide-angle section, the refractive wave of the hydrate layer is evident when using P-wave components but identification is difficult with S-wave components. This velocity model illustrates the sensitivity of P- and S-wave components to gas hydrate. The use of this polarization method and results of analysis provide technical and theoretical support for research on hydrate deposits and other geological features in the Shenhu area.

  12. THE NON-THERMAL, TIME-VARIABLE RADIO EMISSION FROM Cyg OB2 no. 5: A WIND-COLLISION REGION

    International Nuclear Information System (INIS)

    Ortiz-Leon, Gisela N.; Loinard, Laurent; RodrIguez, Luis F.; Dzib, Sergio A.; Mioduszewski, Amy J.

    2011-01-01

    The radio emission from the well-studied massive stellar system Cyg OB2 no. 5 is known to fluctuate with a period of 6.7 years between a low-flux state, when the emission is entirely of free-free origin, and a high-flux state, when an additional non-thermal component (of hitherto unknown nature) appears. In this paper, we demonstrate that the radio flux of that non-thermal component is steady on timescales of hours and that its morphology is arc-like. This shows that the non-thermal emission results from the collision between the strong wind driven by the known contact binary in the system and that of an unseen companion on a somewhat eccentric orbit with a 6.7 year period and a 5-10 mas semimajor axis. Together with the previously reported wind-collision region located about 0.''8 to the northeast of the contact binary, so far Cyg OB2 no. 5 appears to be the only multiple system known to harbor two radio-imaged wind-collision regions.

  13. Paraffin oil as a "methane vector" for rapid and high cell density cultivation of Methylosinus trichosporium OB3b.

    Science.gov (United States)

    Han, Bing; Su, Tao; Wu, Hao; Gou, Zhongxuan; Xing, Xin-Hui; Jiang, Hao; Chen, Yin; Li, Xin; Murrell, J Colin

    2009-06-01

    Slow growth and relatively low cell densities of methanotrophs have limited their uses in industrial applications. In this study, a novel method for rapid cultivation of Methylosinus trichosporium OB3b was studied by adding a water-immiscible organic solvent in the medium. Paraffin oil was the most effective at enhancing cell growth and final cell density. This is at least partially due to the increase of methane gas transfer between gas and medium phases since methane solubility is higher in paraffin than in water/nitrate minimal salt medium. During cultivation with paraffin oil at 5% (v/v) in the medium, M. trichosporium OB3b cells also showed higher concentrations of the intermediary metabolites, such as formic acid and pyruvic acid, and consumed more methane compared with the control. Paraffin as methane vector to improve methanotroph growth was further studied in a 5-L fermentor at three concentrations (i.e., 2.5%, 5%, and 10%). Cell density reached about 14 g dry weight per liter with 5% paraffin, around seven times higher than that of the control (without paraffin). Cells cultivated with paraffin tended to accumulate around the interface between oil droplets and the water phase and could exist in oil phase in the case of 10% (v/v) paraffin. These results indicated that paraffin could enhance methanotroph growth, which is potentially useful in cultivation of methanotrophs in large scale in industry.

  14. Oriental upper blepharoplasty.

    Science.gov (United States)

    Weng, Chau-Jin

    2009-02-01

    Aesthetic surgery of the upper eyelids is a very common procedure performed in cosmetic practices around the world. The word blepharoplasty, however, has a different meaning in Asia than it does elsewhere. Orientals have different periorbital anatomic characteristics, their motivations for seeking eyelid treatment are different, and operative techniques have been adapted consequently. There are also many eyelid shapes among Orientals, mostly with regard to the presence and location of the supratarsal fold and/or presence of an epicanthal fold. The surgeon must therefore master a range of surgical procedures to treat these variations adequately. It is critical to know the indications for each blepharoplasty technique as well as their complications to select the right surgery and avoid unfavorable results. Epicanthoplasty performed on the right patient can greatly improve aesthetic results while retaining ethnic characteristics. This article will discuss Oriental eyelid characteristics, preoperative patient assessment, commonly used corrective techniques for the "double-eyelid" creation, and complications and how to avoid them.

  15. Effects of copper mineralogy and methanobactin on cell growth and sMMO activity in Methylosinus trichosporium OB3b

    Directory of Open Access Journals (Sweden)

    C. Dennison

    2011-10-01

    Full Text Available Controls on in situ methanotroph activity are not well understood. One potentially important parameter is copper (Cu because it is the metal-centre of particulate methane monooxygenase (pMMO, the most active enzyme for oxidizing methane to methanol. Further, Cu-to-cell ratios influence the relative expression of pMMO versus the alternate soluble MMO (sMMO in some species. However, most methanotroph studies only have assessed readily soluble forms of Cu (e.g. CuCl2 and there is a dearth of Cu-related activity data for Cu sources more common in the environment. Here we quantified sMMO activity (as a practical indicator of Cu availability and growth kinetics in Methylosinus trichosporium OB3b, an organism that expresses both pMMO and sMMO, when grown on Cu-minerals with differing dissolution equilibria to assess how mineral type and methanobactin (mb might influence in situ methanotroph activity. Mb is a molecule produced by M. trichosporium OB3b that has a high affinity for Cu, reduces Cu toxicity, and may influence Cu availability in terrestrial systems. CuCO3.Cu(OH2 and CuO were chosen for study based on modelling data, reflecting more and less soluble minerals, respectively, and were found to affect M. trichosporium OB3b activity differently. Cells grew without growth lag and with active pMMO on CuCO3.Cu(OH2, regardless of the amount of mineral supplied (−1. The organism also grew well on CuO; however, significant sMMO activity was retained up to 50 μmoles Cu-total l−1, although sMMO activity was suppressed by supplemental mb and-or direct cell-mineral contact. Mb addition increased growth rates (p < 0.05 with both minerals. Results show mb broadly stimulates growth, but Cu mineralogy and mb dictate whether sMMO or pMMO is active in the cells. This explains why sMMO activity has been seen in soils with high Cu and also has implications for predicting dominant MMO activity in terrestrial bioremediation applications.

  16. Upper airway resistance syndrome.

    Science.gov (United States)

    Montserrat, J M; Badia, J R

    1999-03-01

    This article reviews the clinical picture, diagnosis and management of the upper airway resistance syndrome (UARS). Presently, there is not enough data on key points like the frequency of UARS and the morbidity associated with this condition. Furthermore, the existence of LIARS as an independent sleep disorder and its relation with snoring and obstructive events is in debate. The diagnosis of UARS is still a controversial issue. The technical limitations of the classic approach to monitor airflow with thermistors and inductance plethysmography, as well as the lack of a precise definition of hypopnea, may have led to a misinterpretation of UARS as an independent diagnosis from the sleep apnea/hypopnea syndrome. The diagnosis of this syndrome can be missed using a conventional polysomnographic setting unless appropriate techniques are applied. The use of an esophageal balloon to monitor inspiratory effort is currently the gold standard. However, other sensitive methods such as the use of a pneumotachograph and, more recently, nasal cannula/pressure transducer systems or on-line monitoring of respiratory impedance with the forced oscillation technique may provide other interesting possibilities. Recognition and characterization of this subgroup of patients within sleep breathing disorders is important because they are symptomatic and may benefit from treatment. Management options to treat UARS comprise all those currently available for sleep apnea/hypopnea syndrome (SAHS). However, the subset of patients classically identified as LIARS that exhibit skeletal craneo-facial abnormalities might possibly obtain further benefit from maxillofacial surgery.

  17. Upper Illinois River basin

    Science.gov (United States)

    Friedel, Michael J.

    1998-01-01

    During the past 25 years, industry and government made large financial investments that resulted in better water quality across the Nation; however, many water-quality concerns remain. Following a 1986 pilot project, the U.S. Geological Survey began implementation of the National Water-Quality Assessment (NAWQA) Program in 1991. This program differs from other national water-quality assessment studies in that the NAWQA integrates monitoring of surface- and ground-water quality with the study of aquatic ecosystems. The goals of the NAWQA Program are to (1) describe current water-quality conditions for a large part of the Nation's freshwater streams and aquifers (water-bearing sediments and rocks), (2) describe how water quality is changing over time, and (3) improve our understanding of the primary natural and human factors affecting water quality.The Upper Illinois River Basin National Water- Quality Assessment (NAWQA) study will increase the scientific understanding of surface- and ground-water quality and the factors that affect water quality in the basin. The study also will provide information needed by water-resource managers to implement effective water-quality management actions and evaluate long-term changes in water quality.

  18. Primary successions of vegetation on technogenic sand patches in oil and gas producing districts of the middle Ob' river basin

    Energy Technology Data Exchange (ETDEWEB)

    Shilova, I I

    1977-11-01

    Intensive economic exploitation of the natural resources of the oil-and-gas producing districts of the central Ob' basin has led to increased exposure of sandy patches over the landscape. These sandy areas are becoming a common site. Technogenic factors involved include, for example, construction projects, oil-drilling and the like. Exposure is accelerated by wind and water erosion. Efforts are underway to reintroduce verdure in the region, and a study has been underway of the features of the ecotope and the stages of natural overgrowth of the area of reclamation. This overgrowth is proceeding well. Vegetation is of the syngenetic succession type, involving four successive stages and formation of associations of a zonal character. Seventy-four species of yeast, 2 species of fungi, 2 of lichens, 19 of Bryophyton and 106 of vascular spore- and covered-seed plants of the area have been recorded, and are tabulated. Recultivation will require due attention to existing conditions. 14 references.

  19. Oczekiwania klienta pokolenia Y w zakresie sposobu obsługi i oferty biur podróży

    OpenAIRE

    Przybylska, Anna

    2015-01-01

    W pracy scharakteryzowano profil klienta w działalności biura podróży oraz rolę, jaką w niej odgrywa. Wskazano na znaczenie odpowiednich relacji z klientem, które wpływają na jego obsługę i zadowolenie. Krótko opisano zarządzanie relacjami z klientem oraz wytyczne do prawidłowego wprowadzenia tych zasad w firmie w celu maksymalizacji zysków. Badania zostały przeprowadzone na grupie konsumentów z przedziału wiekowego charakteryzującego pokolenie Y oraz pokolenie X – w celach ...

  20. New Brown Dwarf Discs in Upper Scorpius Observed with WISE

    Science.gov (United States)

    Dawson, P.; Scholz, A.; Ray, T. P.; Natta, A.; Marsh, K. A.; Padgett, D.; Ressler, M. E.

    2013-01-01

    We present a census of the disc population for UKIDSS selected brown dwarfs in the 5-10 Myr old Upper Scorpius OB association. For 116 objects originally identified in UKIDSS, the majority of them not studied in previous publications, we obtain photometry from the Wide-Field Infrared Survey Explorer data base. The resulting colour magnitude and colour colour plots clearly show two separate populations of objects, interpreted as brown dwarfs with discs (class II) and without discs (class III). We identify 27 class II brown dwarfs, 14 of them not previously known. This disc fraction (27 out of 116, or 23%) among brown dwarfs was found to be similar to results for K/M stars in Upper Scorpius, suggesting that the lifetimes of discs are independent of the mass of the central object for low-mass stars and brown dwarfs. 5 out of 27 discs (19 per cent) lack excess at 3.4 and 4.6 microns and are potential transition discs (i.e. are in transition from class II to class III). The transition disc fraction is comparable to low-mass stars.We estimate that the time-scale for a typical transition from class II to class III is less than 0.4 Myr for brown dwarfs. These results suggest that the evolution of brown dwarf discs mirrors the behaviour of discs around low-mass stars, with disc lifetimes of the order of 5 10 Myr and a disc clearing time-scale significantly shorter than 1 Myr.

  1. Migration of global radioactive fallout to the Arctic Ocean (on the example of the Ob's river drainage basin).

    Science.gov (United States)

    Miroshnikov, A; Semenkov, I

    2012-11-01

    This article provides an assessment of the impact of global fallout on (137)Cs contamination in the bottom sediments of Kara Sea. The erosiveness of 10th-level river basins was estimated by landscape-geochemical and geomorphological characteristics. All 10th-level basins (n=154) were separated into three groups: mountain, mountain-lowland and plain. Four different types of basins were identified depending on the geochemical conditions of the migration of radiocaesium in the plain and mountain-lowland. Classifications of types were carried out using the geographic information systems-based approach. The Ob River's macroarena covers 3.5 million km(2). Internal drainage basins cover 23 % of the macroarena and accumulate whole radiocaesium from the global fallout. The remaining territory is transitional for the (137)Cs. The field research works performed in the three plain first-level basins allow one to estimate the radiocaesium run-off. The calculations show that 7 % of (137)Cs was removed from the first-level basin in arable land. Accumulation of radiocaesium in the first-level basin under undisturbed forest is 99.8 %. The research shows that (137)Cs transfer from the humid basins is in the range of 6.9-25.5 TBq and for semi-humid basins 5.6-285.5 TBq. The areas of these basins cover 40 and 8 % of the Ob River's macroarena, respectively. Drainage lakes and reservoir drainage basins make up 22 % of the macroarena. Mountainous and semi-arid drainage basins cover 7 % of the macroarena.

  2. TOWARD COMPLETE STATISTICS OF MASSIVE BINARY STARS: PENULTIMATE RESULTS FROM THE CYGNUS OB2 RADIAL VELOCITY SURVEY

    Energy Technology Data Exchange (ETDEWEB)

    Kobulnicky, Henry A.; Lundquist, Michael J.; Burke, Jamison; Chapman, James; Keller, Erica; Lester, Kathryn; Rolen, Emily K.; Topel, Eric; Bhattacharjee, Anirban; Smullen, Rachel A.; Álvarez, Carlos A. Vargas; Runnoe, Jessie C.; Dale, Daniel A.; Brotherton, Michael M. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82070 (United States); Kiminki, Daniel C., E-mail: chipk@uwyo.edu, E-mail: jburke2@swarthmore.edu, E-mail: jc6380@mcla.edu, E-mail: kelle22e@mtholyoke.edu, E-mail: kvl214@lehigh.edu, E-mail: emily.k.rolen@vanderbilt.edu, E-mail: topel@stolaf.edu [Department of Astronomy, University of Arizona, Tucson, AZ 85721 (United States)

    2014-08-01

    We analyze orbital solutions for 48 massive multiple-star systems in the Cygnus OB2 association, 23 of which are newly presented here, to find that the observed distribution of orbital periods is approximately uniform in log P for P < 45 days, but it is not scale-free. Inflections in the cumulative distribution near 6 days, 14 days, and 45 days suggest key physical scales of ≅0.2, ≅0.4, and ≅1 A.U. where yet-to-be-identified phenomena create distinct features. No single power law provides a statistically compelling prescription, but if features are ignored, a power law with exponent β ≅ –0.22 provides a crude approximation over P = 1.4-2000 days, as does a piece-wise linear function with a break near 45 days. The cumulative period distribution flattens at P > 45 days, even after correction for completeness, indicating either a lower binary fraction or a shift toward low-mass companions. A high degree of similarity (91% likelihood) between the Cyg OB2 period distribution and that of other surveys suggests that the binary properties at P ≲ 25 days are determined by local physics of disk/clump fragmentation and are relatively insensitive to environmental and evolutionary factors. Fully 30% of the unbiased parent sample is a binary with period P < 45 days. Completeness corrections imply a binary fraction near 55% for P < 5000 days. The observed distribution of mass ratios 0.2 < q < 1 is consistent with uniform, while the observed distribution of eccentricities 0.1 < e < 0.6 is consistent with uniform plus an excess of e ≅ 0 systems. We identify six stars, all supergiants, that exhibit aperiodic velocity variations of ∼30 km s{sup –1} attributed to atmospheric fluctuations.

  3. Release and transport of artificial radionuclides from nuclear weapons related activities in the Ob River, Siberia over the course of the nuclear age

    International Nuclear Information System (INIS)

    Sayles, F.L.; Kenna, T.C.; Livingston, H.D.

    1999-01-01

    Studies of sediment cores from lakes on the flood plain of the Ob River, Siberia have been used to develop a history of the release, transport, and deposition of artificial radionuclides related to the development and testing of nuclear weapons over the duration of the nuclear age (∼1950 to the present) in this major Arctic river system. The Ob is of particular importance in this regard as two of the former Soviet Union's major weapons production plants, Mayak and Tomsk-7, and the Semipalatinsk test site are located within the Ob drainage basin. Accidents and intentional releases of radionuclides at both plants have been substantial, raising the issue of transport throughout this extensive river system as well as delivery to the Arctic Ocean. Our studies have included determining sediment profiles of 239,240 Pu, 137 Cs, and the natural nuclide 210 Pb and its parent 226 Ra in a number of cores from the Ob delta, as well as analysis of 239 Pu, 240 Pu, and 237 Np. The latter provide sensitive measures of the presence of non-fallout materials derived from weapons production activities

  4. Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance

    DEFF Research Database (Denmark)

    Fuentes, T; Ara, I; Guadalupe-Grau, A

    2010-01-01

    To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin...

  5. Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Erkasap, N.; Ozkurt, M. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Erkasap, S.; Yasar, F. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uzuner, K. [Department of Physiology, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Ihtiyar, E. [Department of General Surgery, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Uslu, S.; Kara, M. [Department of Biochemistry, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey); Bolluk, O. [Department of Biostatistics, Osmangazi University Medical Faculty, Meselik, Eskisehir (Turkey)

    2013-03-19

    The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

  6. Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    International Nuclear Information System (INIS)

    Erkasap, N.; Ozkurt, M.; Erkasap, S.; Yasar, F.; Uzuner, K.; Ihtiyar, E.; Uslu, S.; Kara, M.; Bolluk, O.

    2013-01-01

    The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis

  7. Leptin receptor (Ob-R mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer

    Directory of Open Access Journals (Sweden)

    N. Erkasap

    Full Text Available The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases and metastatic colon (13 cases cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher than in local colorectal cancer tissues. On the other hand, mean serum leptin concentration was significantly higher in local colorectal cancer patients compared to patients with metastatic colorectal cancer. The results of the present study suggest a role for leptin in the progression of colon cancer to metastatic disease without weight loss. In other words, significantly increased Ob-R mRNA expression and decreased serum leptin concentration in patients with metastatic colon cancer indicate that sensitization to leptin activity may be a major indicator of metastasis to the colon tissue and the determination of leptin concentration and leptin gene expression may be used to aid the diagnosis.

  8. Examination of the site amplification factor of OBS and their application to magnitude estimation and ground-motion prediction for EEW

    Science.gov (United States)

    Hayashimoto, N.; Hoshiba, M.

    2013-12-01

    1. Introduction Ocean bottom seismograph (OBS) is useful for making Earthquake Early Warning (EEW) earlier. However, careful handling of these data is required because the installation environment of OBSs may be different from that of land stations. Site amplification factor is an important factor to estimate the magnitudes, and to predict ground motions (e.g. seismic intensity) in EEW. In this presentation, we discuss the site amplification factor of OBS in the Tonankai area of Japan from these two points of view. 2. Examination of magnitude correction of OBS In the EEW of JMA, the magnitude is estimated from the maximum amplitude of the displacement in real time. To provide the fast magnitude estimation, the magnitude-estimation algorithm switches from the P to S formula (Meew(P) to Meew(S)) depending on the expected S-phase arrival (Kamigaichi,2004). To estimate the magnitude correction for OBS, we determine Meew(P) and Meew(S) at OBSs and compare them with JMA magnitude (Mjma). We find Meew(S) at OBS is generally larger than Mjma by approximately 0.6. The slight differences of spatial distribution of Meew(S) amplification are also found among other OBSs. From the numerical simulations, Nakamura et al. (MGR,submitted) pointed out that the oceanic layer and the low-velocity sediment layers causes the large amplifications in low frequency range (0.1-0.2Hz) at OBSs. We conclude that the site effect of OBS characterized by such a low velocity sediment layers causes those amplification of Magnitude. 3. The frequency-dependent site factor of OBS estimated from Fourier spectrum ratio and their application for prediction of seismic intensity of land station We compare Fourier spectra of S-wave portion on OBSs with those on adjacent land stations. Station pair whose distance is smaller than 50 km is analyzed, and we obtain that spectral ratio of land station (MIEH05 of the KiK-net/NIED) to OBS (KMA01 of the DONET/JAMSTEC) is 5-20 for frequencies 10-20Hz for both

  9. Soils of slopes in the taiga zone of the Middle Ob reaches

    Science.gov (United States)

    Karavaeva, N. A.; Sokolova, T. A.

    2015-06-01

    The morphology, chemical properties, composition of phyllosilicates, as well as their transformation in loamy soils developing on slopes of ridges of the Vakh Upland in Western Siberia, are discussed. Data on two soil profiles-gleyic svetlozem of the middle slope and podzolized gleyzem of the footslope—are presented. Both soils have an acid reaction. The textural differentiation is weakly pronounced in the gleyic svetlozem and more pronounced in the podzolized gleyzem. The soils differ in their cryological conditions. The thawing depth in the svetlozem is about 60-70 cm, and the lower part of the profile to a depth of 3.2 m largely remains in the frozen state. Its complete thawing is only possible during the warm climatic cycles. This is a seasonally frozen soil with the long-lasting frozen state. It is characterized by the thick cryometamorphic (CRM) horizon. The gleyzem is a "normal" seasonally frozen soil with complete thawing of seasonal frost in summer. The CRM horizon is absent in its profile. The alteration of clay minerals in the soil profiles includes their partial dissolution, the formation of soil chlorites, and the transformation of illite into more labile structures. In the upper horizons of both soils, this transformation proceeds through the stage of mixed-layered illite-smectites. In the gleyzem, it reaches a more advanced stage of the formation of beidellite. The cryometamorphic horizons are specified by some amorphization of phyllosilicates and, probably, by the partial dissolution of their crystal lattices under the impact of frequent zero-temperature transitions and cryogenesis in the frozen state.

  10. Dum lucet - bibamus sodales. Ob und wie wir Archäologen die Alten verstehen

    Directory of Open Access Journals (Sweden)

    Iva Mikl Curk

    2004-12-01

    -Schälchens, welches uns nur durch eine Publikation bekannt ist (Mratschek 1987, könnte aber den Trinker - ob er schon ein Neusiedler aus Norditalien kommend oder ein Einheimischer, welcher das Schälchen zur Gästegabe bekommen hat, war - direkter ansprechen. Mit Bleiglasur glasierte Ware trägt zum Teil im Reliefdekor noch naturgetreu abgebildete Efeu- und Weinreben-Ranken, die aber bald größtenteils stilisiert werden. Manches Gefäß von dieser Sorte wurde schon in den provinziellen Werkstätten hergestellt, in der ersten Phase allerdings als Modellarbeit der italischen (oder in Italien ausgebildeten Meister. Das beweisen sehr klar die Unterschiede an der Ausarbeitung, wenn man die Gegenstände aus Poetovio z.B. mit denen aus Carnuntum vergleicht. Aus Norditalien stammt jedenfalls auch eine Zahl der Gesichtbecher, besonders derjenigen, die als Grabbeigabe in Emona ausgegraben worden sind (Brathwaite 2001; Schindler Kaudelka, Butti Ronchetti, Schneider 2000. Da aber auch in Emona ein spezifisch gearbeitetes Gefäß mit der Darstellung vom männlichen Gesicht als Graburne gedient hat, und die Scherben aus Siedlungsspuren und aus der Töpferwerkstätte in Poetovio wieder andere Eigenschaften aufweisen, würde die Autorin, was die Bestimmung solcher Gefäße betrifft, die Meinung vertreten, dass sie sowohl für den Gebrauch im Kultus als auch zum Erheitern der Tischrunde gedacht gewesen seien, wenn auch für verschiedene Umgebungen und nicht gleich in der Ausführung. Die Reihe des oben dargestellten Trinkgeschirrs stammte sozusagen ausschließlich aus dem mittelmeerländischen Kulturkreis oder aus direktem Import. Das einheimische Element schien seine Vorstellungen nicht durch naturgetreue Abbildungen an den Artefakten des täglichen Lebens kund gegeben zu haben. In den lokalen Werkstätten sind sogar direkte Nachbildungen, auch technisch so einfach, wie das bei Keramik möglich ist, kaum vorhanden. Das wird auch durch einen Topf von Poetovio (jetzt im Landesmuseum in Graz, der

  11. Extensive upper respiratory tract sarcoidosis

    Science.gov (United States)

    Soares, Mafalda Trindade; Sousa, Carolina; Garanito, Luísa; Freire, Filipe

    2016-01-01

    Sarcoidosis is a chronic granulomatous disease of unknown aetiology. It can affect any part of the organism, although the lung is the most frequently affected organ. Upper airway involvement is rare, particularly if isolated. Sarcoidosis is a diagnosis of exclusion, established by histological evidence of non-caseating granulomas and the absence of other granulomatous diseases. The authors report a case of a man with sarcoidosis manifesting as a chronic inflammatory stenotic condition of the upper respiratory tract and trachea. PMID:27090537

  12. Oncoplastic Surgery for Upper/Upper Inner Quadrant Breast Cancer.

    Science.gov (United States)

    Lin, Joseph; Chen, Dar-Ren; Wang, Yu-Fen; Lai, Hung-Wen

    2016-01-01

    Tumors located in the upper/upper inner quadrant of the breast warrant more attention. A small lesion relative to the size of breast in this location may be resolved by performing a level I oncoplastic technique. However, a wide excision may significantly reduce the overall quality of the breast shape by distorting the visible breast line. From June 2012 to April 2015, 36 patients with breast cancer located in the upper/upper inner quadrant underwent breast-conservation surgery with matrix rotation mammoplasty. According to the size and location of the tumor relative to the nipple-areola complex, 11 patients underwent matrix rotation with periareolar de-epithelialization (donut group) and the other 25 underwent matrix rotation only (non-donut group). The cosmetic results were self-assessed by questionnaires. The average weights of the excised breast lumps in the donut and non-donut groups were 104.1 and 84.5 g, respectively. During the 3-year follow-up period, local recurrence was observed in one case and was managed with nipple-sparing mastectomy followed by breast reconstruction with prosthetic implants. In total, 31 patients (88.6%) ranked their postoperative result as either acceptable or satisfactory. The treated breasts were also self-evaluated by 27 patients (77.1%) to be nearly identical to or just slightly different from the untreated side. Matrix rotation is an easy breast-preserving technique for treating breast cancer located in the upper/upper inner quadrant of the breast that requires a relatively wide excision. With this technique, a larger breast tumor could be removed without compromising the breast appearance.

  13. Oncoplastic Surgery for Upper/Upper Inner Quadrant Breast Cancer.

    Directory of Open Access Journals (Sweden)

    Joseph Lin

    Full Text Available Tumors located in the upper/upper inner quadrant of the breast warrant more attention. A small lesion relative to the size of breast in this location may be resolved by performing a level I oncoplastic technique. However, a wide excision may significantly reduce the overall quality of the breast shape by distorting the visible breast line. From June 2012 to April 2015, 36 patients with breast cancer located in the upper/upper inner quadrant underwent breast-conservation surgery with matrix rotation mammoplasty. According to the size and location of the tumor relative to the nipple-areola complex, 11 patients underwent matrix rotation with periareolar de-epithelialization (donut group and the other 25 underwent matrix rotation only (non-donut group. The cosmetic results were self-assessed by questionnaires. The average weights of the excised breast lumps in the donut and non-donut groups were 104.1 and 84.5 g, respectively. During the 3-year follow-up period, local recurrence was observed in one case and was managed with nipple-sparing mastectomy followed by breast reconstruction with prosthetic implants. In total, 31 patients (88.6% ranked their postoperative result as either acceptable or satisfactory. The treated breasts were also self-evaluated by 27 patients (77.1% to be nearly identical to or just slightly different from the untreated side. Matrix rotation is an easy breast-preserving technique for treating breast cancer located in the upper/upper inner quadrant of the breast that requires a relatively wide excision. With this technique, a larger breast tumor could be removed without compromising the breast appearance.

  14. OB CITY–Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies

    Science.gov (United States)

    Hu, Ruofei; Cancela, Jorge; Cea, Gloria; Vlachopapadopoulou, Elpis-Athina; Fotiadis, Dimitrios I.; Fico, Giuseppe

    2016-01-01

    Childhood obesity is becoming one of the 21st century’s most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children’s lifestyle to arrest the disease. Information and communication technologies (ICTs) have not been widely employed in this intervention, and most of existing ICTs systems are not having a long-term effect. The purpose of this paper is to define a system to support family-based intervention through a state-of-the-art analysis of family-based interventions and related technological solutions first, and then using the analytic hierarchy process to derive a childhood obesity family-based behavior intervention model, and finally to provide a prototype of a system called OB CITY. The system makes use of applied behavior analysis, affective computing technologies, as well as serious game and gamification techniques, to offer long term services in all care dimensions of the family-based behavioral intervention aiming to provide positive effects to the treatment of childhood obesity. PMID:27602306

  15. CSO BOLOCAM 1.1 mm CONTINUUM MAPPING OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

    International Nuclear Information System (INIS)

    Aspin, Colin; Beck, Tracy L.; Davis, Chris J.

    2011-01-01

    We present a 1.1 mm map of the Braid Nebula star formation region in Cygnus OB7 taken using Bolocam on the Caltech Submillimeter Observatory. Within the 1 deg 2 covered by the map, we have detected 55 cold dust clumps all of which are new detections. A number of these clumps are coincident with IRAS point sources although the majority are not. Some of the previously studied optical/near-IR sources are detected at 1.1 mm. We estimate total dust/gas masses for the 55 clumps together with peak visual extinctions. We conclude that over the whole region, approximately 20% of the clumps are associated with IRAS sources suggesting that these are protostellar objects. The remaining 80% are classed as starless clumps. In addition, both FU Orionis (FUor) like objects in the field, the Braid Star and HH 381 IRS, are associated with strong millimeter emission. This implies that FUor eruptions can occur at very early stages of pre-main-sequence life. Finally, we determine that the cumulative clump mass function for the region is very similar to that found in both the Perseus and ρ Ophiuchus star-forming regions.

  16. A WIDE-FIELD NARROWBAND OPTICAL SURVEY OF THE BRAID NEBULA STAR FORMATION REGION IN CYGNUS OB7

    International Nuclear Information System (INIS)

    Magakian, Tigran Yu.; Nikogossian, Elena H.; Movsessian, Tigran; Aspin, Colin; Pyo, Tae-Soo; Khanzadyan, Tigran; Smith, Michael D.; Mitchison, Sharon; Davis, Chris J.; Beck, Tracy L.; Moriarty-Schieven, Gerald H.

    2010-01-01

    We study the population of Herbig-Haro (HH) flows and jets in an area of Cygnus OB7 designated the Braid Nebula star formation region. This complex forms part of the L 1003 dark cloud, and hosts two FU Orionis (FUor)-like objects as well as several other active young stars. To trace outflow activity and to relate both known and newly discovered flows to young star hosts we intercompare new, deep, narrowband Hα and [S II] optical images taken on the Subaru 8 m Telescope on Mauna Kea, Hawaii. Our images show that there is considerable outflow and jet activity in this region suggesting the presence of an extensive young star population. We confirm that both of the FUor-like objects drive extensive HH flows and document further members of the flows in both objects. The L 1003 star formation complex is a highly kinematically active region with young stars in several different stages of evolution. We trace collimated outflows from numerous young stars although the origin of some HH objects remains elusive.

  17. OB CITY-Definition of a Family-Based Intervention for Childhood Obesity Supported by Information and Communication Technologies.

    Science.gov (United States)

    Hu, Ruofei; Cancela, Jorge; Arredondo Waldmeyer, Maria Teresa; Cea, Gloria; Vlachopapadopoulou, Elpis-Athina; Fotiadis, Dimitrios I; Fico, Giuseppe

    2016-01-01

    Childhood obesity is becoming one of the 21st century's most important public health problems. Nowadays, the main treatment of childhood obesity is behavior intervention that aims at improve children's lifestyle to arrest the disease. Information and communication technologies (ICTs) have not been widely employed in this intervention, and most of existing ICTs systems are not having a long-term effect. The purpose of this paper is to define a system to support family-based intervention through a state-of-the-art analysis of family-based interventions and related technological solutions first, and then using the analytic hierarchy process to derive a childhood obesity family-based behavior intervention model, and finally to provide a prototype of a system called OB CITY. The system makes use of applied behavior analysis, affective computing technologies, as well as serious game and gamification techniques, to offer long term services in all care dimensions of the family-based behavioral intervention aiming to provide positive effects to the treatment of childhood obesity.

  18. VizieR Online Data Catalog: Extinction law in the Cep OB3b young cluster (Allen+, 2014)

    Science.gov (United States)

    Allen, T. S.; Prchlik, J. J.; Megeath, S. T.; Gutermuth, R. A.; Pipher, J. L.; Naylor, T.; Jeffries, R. D.

    2017-06-01

    We use Johnson V and Cousins Rc (hereafter called VR) band phot from the Isaac Newton Telescope (INT), compiled in the catalog of Littlefair et al. (2010, J/MNRAS/403/545). The R-band photometry was obtained using the Sloan r filter. It was calibrated against photometric standard stars measured in the Cousins Rc filter with an arbitrary zero point. Moderate resolution ((λ/Δλ)~1000-2000, FWHM resolution of about 6 Å) optical spectra (covering 4000-9000 Å) were obtained for ~1700 sources toward Cep OB3b using the multi-fiber spectrograph Hectospec on the MMT telescope. About 600 sources were selected for observation because they were determined to be possible cluster members (Allen et al. 2012, J/ApJ/750/125), based on indicators of youth, such as IR emission due to circumstellar dusty material and heightened X-ray activity. We use an extinction map from Allen et al. (2012, J/ApJ/750/125) to initially estimate the extinction toward each source. This map is derived using the 2MASS Point Source Catalog (Skrutskie et al. 2006AJ....131.1163S, Cat. VII/233) H and Ks band photometry of background stars. (1 data file).

  19. Analysis of seismic reflectivity and AVO pattern of BSR using OBS data in the southwestern offshore region of Taiwan

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, W.B.; Yang, H.R. [Jinwen Univ. of Science and Technology, Hsintien City, Taipei County, Taiwan (China). Dept. of Environment and Property Management; Schnurle, P.; Liu, C.S. [National Taiwan Univ., Taipei, Taiwan (China). Inst. of Oceanography; Lee, C.S. [National Taiwan Ocean Univ., Keelung, Taiwan (China). Inst. of Applied Earth Science; Wang, Y.; Chung, S.H.; Chen, S.C. [Ministry of Economic Affairs, Taiwan (China). Central Geological Survey

    2008-07-01

    Regional multi-channel seismic reflection profiles that were conducted in Taiwan from 2003 to 2006 resulted in the identification of a gas hydrate-related bottom simulating reflector (BSR) in the broad southwestern offshore region of Taiwan. In order to understand the regional distribution of methane hydrate bearing layers and explore concentrated hydrate bearing layers, this paper presented a comprehensive analysis of reflection coefficient and amplitude-versus-offset (AVO) pattern of BSR using ocean bottom seismographs (OBSs) seismic data acquired in the southwestern offshore region of Taiwan. The study focused on the analysis and interpretation of airgun array signals recorded by OBSs during 2004 and 2006. Ten profiles of seismic reflection/refraction with a total length of about 140 km and recorded by 50 recovered OBSs were acquired on the active and passive margins in offshore southwestern Taiwan. Amplitudes of the direct water arrival, the multiple, and the BSR were picked interactively for all the OBS lines. A quantitative representation of reflector strength was provided by calculation of reflection coefficients. In general, the seafloor reflection coefficients for the active and passive margins were estimated as 0.1-0.25. The paper presented the data and analysis as well as the results of the study. It was concluded that the results of calculated reflection coefficient of the BSR in offshore southwest Taiwan suggested that inferred hydrate concentration for the passive margin profiles was relatively higher than that for the active margin profiles. 4 refs.

  20. Spatial clustering of summer temperature maxima from the CNRM-CM5 climate model ensembles & E-OBS over Europe

    Directory of Open Access Journals (Sweden)

    Margot Bador

    2015-09-01

    Full Text Available Reducing the dimensionality of the complex spatio-temporal variables associated with climate modeling, especially ensembles of climate models, is a challenging and important objective. For studies of detection and attribution, it is especially important to maintain information related to the extreme values of the atmospheric processes. Typical methods for data reduction involve summarizing climate model output information through means and variances, which does not preserve any information about the extremes. In order to help solve this challenge, a dependence summary measure appropriate for extreme values must be inferred. Here, we adapt one such measure from a recent study to a larger domain with a different variable and gridded data from observations and climate model ensembles, i.e. E-OBS observations and the CNRM-CM5 model. The handling of such ensembles of data is proposed, as well as a comparison of the spatial clusterings between two different ensembles, here a present-day and a future ensemble of climate simulations. This method yields valid information concerning extremes, while greatly reducing the data set.

  1. Gas expulsions and biological activity recorded offshore Molene Island, Brittany (France): video supervised recording of OBS data and analogue modelling

    Science.gov (United States)

    Klingelhoefer, F.; Géli, L.; Dellong, D.; Evangelia, B.; Tary, J. B.; Bayrakci, G.; Lantéri, N.; Lin, J. Y.; Chen, Y. F.; Chang, E. T. Y.

    2016-12-01

    Ocean bottom seismometers (OBS) commonly record signals from Short Duration Events (SDEs), having characteristics that are very different from those produced by tectonic earthquakes, e.g.: durations Brittany within the field of view of the EMSO-Molene underwater observatory, at a water depth of 12 m. The camera images and the recordings reveal the presence of crabs, octopus and several species of fish. Other acoustic signals can be related to the presence of moving algae or the influence from bad weather. Tides produce characteristic curves in the noise recorded on the geophones. SDEs have been recorded on both instruments, that may well have been caused by gas expulsions from the seabed into the water. In order to verify this hypothesis, an aquarium was filled with water overlying an even grain-sized quartz sand layer. A constant air supply through a narrow tube produced gas bubbles in a regular manner and an immersed ocean bottom geophone recorded the resulting acoustic signals. The bubbles tend to have a uniform size and to produce a waveform very close to those found on the OBSs. By comparing the number of SDEs and the volume of escaped air, estimates can be made regarding the volume of gas escaping the seafloor in different environments.

  2. Génétique épidémiologique et moléculaire de l’obésité humaine

    Directory of Open Access Journals (Sweden)

    Iron Albert

    2000-01-01

    Full Text Available L’obésité est une pathologie majeure pour plusieurs raisons qu’il est difficile de hiérarchiser. D’abord parce qu’elle est commune, concernant aujourd’hui près d’un individu sur trois dans les pays industrialisés. Ensuite, parce qu’elle est grave en raison des complications nombreuses et sévères, parmi lesquelles on peut citer des cardiopathies, le diabète, l’HTA, des cancers, etc. Enfin, parce que répondant à la définition de maladie multifactorielle résultant de l’interaction entre des facteurs héréditaires et des facteurs environnementaux, sa connaissance a beaucoup progressé ces dernières années, notamment grâce à l’apport de la génétique moléculaire. À l’échelon individuel et d’une manière simple, on peut définir l’obésité comme résultant d’un excès de tissu adipeux qui va se traduire par un poids élevé par rapport à ce qu’on peut considérer comme étant un poids idéal donné par la formule de Lorentz : Poids idéal (kg = Taille (cm – 100 – [Taille (cm – 150]/4 (homme ou 2,5 (femme Sous l’angle épidémiologique, c’est-à-dire à l’échelle des populations, l’obésité sera définie à partir de critères de nature anthropologique utilisés aussi en clinique pour typer le patient obèse. On peut prendre en compte le rapport du tour de hanche sur le tour de taille (qui permet de définir une obésité de type androïde ou gynoïde selon que ce rapport est supérieur ou inférieur à 0,85 ou la mesure de l’adiposité évaluée par l’appréciation des plis cutanés (en particulier le pli tricipital ou surtout l’indice de corpulence qui est le critère majeur des épidémiologistes pour l’étude de l’obésité chez l’adulte. Cet indice est la référence pour la définition de l’obésité chez l’adulte ; il est aussi appelé indice de masse corporelle (IMC ou indice de Quetelet ; il exprime le rapport du poids (en kg au carré de la taille (en m

  3. Trening za razvijanje občutka za števila in količine pri predšolskih otrocih s posebnimi potrebami

    OpenAIRE

    Kuplenk, Petra

    2017-01-01

    Tako otroci kot tudi odrasli se z matematiko srečujemo na vsakem koraku, pa naj bo to na poti v vrtec, službo ali pa pri delu doma. Matematika vsakodnevno vpliva na naše življenje in delo. Na delovnem mestu, v vrtcu, opažam vse večje težave otrok s posebnimi potrebami na področju razvoja občutka za števila in količine. V predšolskem obdobju je namreč nujno, da otroci razvijejo občutek za števila in količine, saj vsa nadaljnja matematična znanja temeljijo na usvojenih spretnostih. V empirič...

  4. Extinctions and Distances to Dark Clouds from 2MASS, MegaCam and IPHAS Surveys: LDN 1525 in the Direction of the Aur OB1 Association

    Directory of Open Access Journals (Sweden)

    Straižys V.

    2010-12-01

    Full Text Available The possibility of applying photometry from the 2MASS J, H, Ks, MegaCam u, g and IPHAS r, i, Hα surveys for determining the distance to the dark cloud LDN1525 (TGU 1192 in the direction of the Aur OB1 association is investigated using the red clump giants. The main dust cloud, probably related to the emission nebulae Sh 2-232, Sh 2-233, Sh 2-235, the molecular cloud and the association Aur OB2, is found to be located at a distance of 1.3 kpc from the Sun. The nebula Sh 2-231 can be an object of the Perseus arm. The maximum extinction AV found in the cloud is close to 6 mag.

  5. Upper atmosphere research at INPE

    International Nuclear Information System (INIS)

    Clemesha, B.R.

    1984-01-01

    Upper atmosphere research at INPE is mainly concerned with the chemistry and dynamics of the stratosphere, upper mesosphere and lower thermosphere, and the middle thermosphere. Experimental work includes lidar observations of the stratospheric aerosol, measurements of stratospheric ozone by Dobson spectrophotometers and by balloon and rocket-borne sondes, lidar measurements of atmospheric sodium, and photometric observations of O, O 2 , OH and Na emissions, including interferrometric measurements of the OI6300 emission for the purpose of determing thermospheric winds and temperature. The airglow observations also include measurements of a number of emissions produced by the precipitation of energetic neutral particles generated by charge exchange in the ring current. Some recent results of INPE's upper atmosphere program are presented. (Author) [pt

  6. A numerical investigation of the sCO2 recompression cycle off-design behaviour, coupled to a sodium cooled fast reactor, for seasonal variation in the heat sink temperature

    International Nuclear Information System (INIS)

    Floyd, J.; Alpy, N.; Moisseytsev, A.; Haubensack, D.; Rodriguez, G.; Sienicki, J.; Avakian, G.

    2013-01-01

    rises in concert with temperature. A significant fall in the loop thermal power and efficiency is observed however, which analysis reveals to be caused by a fall in pressure ratio that is an inevitable result of the non-ideal nature of sCO 2 . Indeed the difference in the compressors off-design performance (the recompression cycle arrangement features 2 parallel compressors) is such that more mass-flow is attracted in the bypass line, which has a negative impact on cycle efficiency. A second series of results are taken for which the main compressor speed alone is controlled (between 50 and 56 rev/s) and successfully maintains a constant thermal power across the sodium–CO 2 heat exchanger. The resulting higher pressure ratio (compared to the fixed speed results) and greater flow rate through the main compressor also lead to higher cycle efficiencies that are close to the optimum achievable for a given heat sink temperature. The series of tests reveals that to achieve a constant thermal power and high efficiency with the sCO 2 cycle at elevated heat sink temperatures, a degree-of-freedom in the compressor performance is necessary

  7. Carbenoxolone treatment ameliorated metabolic syndrome in WNIN/Ob obese rats, but induced severe fat loss and glucose intolerance in lean rats.

    Directory of Open Access Journals (Sweden)

    Siva Sankara Vara Prasad Sakamuri

    Full Text Available BACKGROUND: 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1 regulates local glucocorticoid action in tissues by catalysing conversion of inactive glucocorticoids to active glucocorticoids. 11β-HSD1 inhibition ameliorates obesity and associated co-morbidities. Here, we tested the effect of 11β-HSD inhibitor, carbenoxolone (CBX on obesity and associated comorbidities in obese rats of WNIN/Ob strain, a new animal model for genetic obesity. METHODOLOGY/PRINCIPAL FINDINGS: Subcutaneous injection of CBX (50 mg/kg body weight or volume-matched vehicle was given once daily for four weeks to three month-old WNIN/Ob lean and obese rats (n = 6 for each phenotype and for each treatment. Body composition, plasma lipids and hormones were assayed. Hepatic steatosis, adipose tissue morphology, inflammation and fibrosis were also studied. Insulin resistance and glucose intolerance were determined along with tissue glycogen content. Gene expressions were determined in liver and adipose tissue. CBX significantly inhibited 11β-HSD1 activity in liver and adipose tissue of WNIN/Ob lean and obese rats. CBX significantly decreased body fat percentage, hypertriglyceridemia, hypercholesterolemia, insulin resistance in obese rats. CBX ameliorated hepatic steatosis, adipocyte hypertrophy, adipose tissue inflammation and fibrosis in obese rats. Tissue glycogen content was significantly decreased by CBX in liver and adipose tissue of obese rats. Severe fat loss and glucose- intolerance were observed in lean rats after CBX treatment. CONCLUSIONS/SIGNIFICANCE: We conclude that 11β-HSD1 inhibition by CBX decreases obesity and associated co-morbidities in WNIN/Ob obese rats. Our study supports the hypothesis that inhibition of 11β-HSD1 is a key strategy to treat metabolic syndrome. Severe fat loss and glucose -intolerance by CBX treatment in lean rats suggest that chronic 11β-HSD1 inhibition may lead to insulin resistance in normal conditions.

  8. New Low-mass Stars in the 25 Orionis Stellar Group and Orion OB1a Sub-association from SDSS-III/BOSS Spectroscopy

    Science.gov (United States)

    Suárez, Genaro; Downes, Juan José; Román-Zúñiga, Carlos; Covey, Kevin R.; Tapia, Mauricio; Hernández, Jesús; Petr-Gotzens, Monika G.; Stassun, Keivan G.; Briceño, César

    2017-07-01

    The Orion OB1a sub-association is a rich low-mass star (LMS) region. Previous spectroscopic studies have confirmed 160 LMSs in the 25 Orionis stellar group (25 Ori), which is the most prominent overdensity of Orion OB1a. Nonetheless, the current census of the 25 Ori members is estimated to be lower than 50% complete, leaving a large number of members to be still confirmed. We retrieved 172 low-resolution stellar spectra in Orion OB1a observed as ancillary science in the SDSS-III/BOSS survey, for which we classified their spectral types and determined physical parameters. To determine memberships, we analyzed the {{{H}}}α emission, Li I λ6708 absorption, and Na I λλ8183, 8195 absorption as youth indicators in stars classified as M type. We report 50 new LMSs spread across the 25 Orionis, ASCC 18, and ASCC 20 stellar groups with spectral types from M0 to M6, corresponding to a mass range of 0.10≤slant m/{M}⊙ ≤slant 0.58. This represents an increase of 50% in the number of known LMSs in the area and a net increase of 20% in the number of 25 Ori members in this mass range. Using parallax values from the Gaia DR1 catalog, we estimated the distances to these three stellar groups and found that they are all co-distant, at 338 ± 66 pc. We analyzed the spectral energy distributions of these LMSs and classified their disks into evolutionary classes. Using H-R diagrams, we found a suggestion that 25 Ori could be slightly older than the other two observed groups in Orion OB1a.

  9. Enhancing the Quality of Service for Real Time Traffic over Optical Burst Switching (OBS Networks with Ensuring the Fairness for Other Traffics.

    Directory of Open Access Journals (Sweden)

    Mohammed A Al-Shargabi

    Full Text Available Optical burst switching (OBS networks have been attracting much consideration as a promising approach to build the next generation optical Internet. A solution for enhancing the Quality of Service (QoS for high priority real time traffic over OBS with the fairness among the traffic types is absent in current OBS' QoS schemes. In this paper we present a novel Real Time Quality of Service with Fairness Ratio (RT-QoSFR scheme that can adapt the burst assembly parameters according to the traffic QoS needs in order to enhance the real time traffic QoS requirements and to ensure the fairness for other traffic. The results show that RT-QoSFR scheme is able to fulfill the real time traffic requirements (end to end delay, and loss rate ensuring the fairness for other traffics under various conditions such as the type of real time traffic and traffic load. RT-QoSFR can guarantee that the delay of the real time traffic packets does not exceed the maximum packets transfer delay value. Furthermore, it can reduce the real time traffic packets loss, at the same time guarantee the fairness for non real time traffic packets by determining the ratio of real time traffic inside the burst to be 50-60%, 30-40%, and 10-20% for high, normal, and low traffic loads respectively.

  10. Rotation of Low-mass Stars in Upper Scorpius and ρ Ophiuchus with K2

    Science.gov (United States)

    Rebull, L. M.; Stauffer, J. R.; Cody, A. M.; Hillenbrand, L. A.; David, T. J.; Pinsonneault, M.

    2018-05-01

    We present an analysis of K2 light curves (LCs) for candidate members of the young Upper Sco (USco) association (∼8 Myr) and the neighboring ρ Oph embedded cluster (∼1 Myr). We establish ∼1300 stars as probable members, ∼80% of which are periodic. The phased LCs have a variety of shapes which can be attributed to physical causes ranging from stellar pulsation and stellar rotation to disk-related phenomena. We identify and discuss a number of observed behaviors. The periods are ∼0.2–30 days with a peak near 2 days and the rapid period end nearing breakup velocity. M stars in the young USco region rotate systematically faster than GK stars, a pattern also present in K2 data for the older Pleiades and Praesepe systems. At higher masses (types FGK), the well-defined period–color relationship for slowly rotating stars seen in the Pleiades and Praesepe systems is not yet present in USco. Circumstellar disks are present predominantly among the more slowly rotating M stars in USco, with few disks in the subday rotators. However, M dwarfs with disks rotate faster on average than FGK systems with disks. For four of these disked M dwarfs, we provide direct evidence for disk locking based on the K2 LC morphologies. Our preliminary analysis shows a relatively mass-independent spin-up by a factor of ∼3.5 between USco and the Pleiades, then mass-dependent spin-down between Pleiades and Praesepe.

  11. [Modeling of Processes of Migration and Accumulation of Radionuclides in Freshwater Ecosystems by the Example of the Samson, Lev, Vandras Rivers Related to the Ob-Irtysh River Basin].

    Science.gov (United States)

    Trapeznikov, A V; Korzhavin, A V; Trapeznikova, V N; Nikolkin, V N

    2016-01-01

    Mathematical models of horizontal distribution and migration of radionuclides are presented in water and floodplain soils of the Samson-Lev-Vandras river system related to the Ob-Irtysh river basin. Integral inventory of radionuclides in the main components of the river ecosystems is calculated. The estimated annual discharge of radionuclides from the Vandras river to the Great Salym river is given. The effect of the removal of man-made radionuclides in the Samson, Lev, Vandras rivers on radioactive contamination of the Ob-Irtysh river system is shown in comparison with the Techa river, that also belongs to the Ob-Irtysh river basin. Despite the presence of an additional radioactive contamination of the Samson floodplain, the transfer of radioactive substances in the Samson, Lev, Vandras rivers has a much smaller impact on the contamination of the Ob-Irtysh river system, compared to the Techa river, prone to a large-scale radioactive contamination.

  12. Angiography of the upper extremity

    International Nuclear Information System (INIS)

    Janevski, B.K.

    1982-01-01

    This thesis provides a description of the technical and medical aspects of arteriography of the upper extremity and an extensive analysis of the angiographic anatomy and pathology of 750 selective studies performed in more than 500 patients. A short historical review is provided of angiography as a whole and of arteriography of the hand in particular. The method of percutaneous transfemoral catheterization of the arteries of the upper extremity and particularly the arteries of the hand is considered, discussing the problems the angiographer encounters frequently, describing the angiographic complications which may occur and emphasizing the measures to keep them to a minimum. The use of vasodilators in hand angiography is discussed. A short description of the embryological patterns persisting in the arteries of the arm is included in order to understand the congenital variations of the arteries of the upper extremity. The angiographic patterns and clinical aspects of the most common pathological processes involving the arteries of the upper extremities are presented. Special attention is paid to the correlation between angiography and pathology. (Auth.)

  13. Approach to upper gastrointestinal bleeding

    African Journals Online (AJOL)

    Upper gastrointestinal haemorrhage has a variety of causes (Table 1) and is the commonest complication of peptic ulceration and portal hypertension. Peptic ulceration in the duo- denum or stomach and oesophageal varices are the conditions most often responsible for patients who have the potential to present.

  14. Horizontal Diplopia Following Upper Blepharoplasty

    Directory of Open Access Journals (Sweden)

    Tomás Ortiz-Basso

    2014-09-01

    Full Text Available Diplopia is an infrequent complication after blepharoplasty. Most of the cases are in its vertical form due to trauma of the extraocular muscles. In this article, we present a case of horizontal diplopia following cosmetic upper blepharoplasty; we review the literature on this unexpected complication and offer some recommendations to avoid it.

  15. Borate mineral assemblages in the system Na2OCaOMgOB2O3H2O

    Science.gov (United States)

    Christ, C.L.; Truesdell, A.H.; Erd, Richard C.

    1967-01-01

    he significant known hydrated borate mineral assemblages (principally of the western United States) in the system Na2OCaOz.sbnd;MgOB2O3H2O are expressible in three ternary composition diagrams. Phase rule interpretation of the diagrams is consistent with observation, if the activity of H2O is generally considered to be determined by the geologic environment. The absence of conflicting tie-lines on a diagram indicates that the several mineral assemblages of the diagram were formed under relatively narrow ranges of temperature and pressure. The known structural as well as empirical formulas for the minerals are listed, and the more recent (since 1960) crystal structure findings are discussed briefly. Schematic Gibbs free energy-composition diagrams based on known solubility-temperature relations in the systems Na2B4O7-H2O and Na2B4O7-NaCl-H2O, are highly useful in the interpretation and prediction of the stability relations in these systems; in particular these diagrams indicate clearly that tincalconite, although geologically important, is everywhere a metastable phase. Crystal-chemical considerations indicate that the same thermodynamic and kinetic behavior observed in the Na2B4O7-H2O system will hold in the Ca2B6O11-H2O system. This conclusion is confirmed by the petrologic evidence. The chemical relations among the mineral assemblages of a ternary diagram are expressed by a schematic "activity-activity" diagram. These activity-activity diagrams permit the tracing-out of the paragenetic sequences as a function of changing cation and H2O activities. ?? 1967.

  16. X-RAY EMISSION FROM THE DOUBLE-BINARY OB-STAR SYSTEM QZ CAR (HD 93206)

    International Nuclear Information System (INIS)

    Parkin, E. R.; Naze, Y.; Rauw, G.; Broos, P. S.; Townsley, L. K.; Pittard, J. M.; Moffat, A. F. J.; Oskinova, L. M.; Waldron, W. L.

    2011-01-01

    X-ray observations of the double-binary OB-star system QZ Car (HD 93206) obtained with the Chandra X-ray Observatory over a period of roughly 2 years are presented. The respective orbits of systems A (O9.7 I+b2 v, P A = 21 days) and B (O8 III+o9 v, P B = 6 days) are reasonably well sampled by the observations, allowing the origin of the X-ray emission to be examined in detail. The X-ray spectra can be well fitted by an attenuated three-temperature thermal plasma model, characterized by cool, moderate, and hot plasma components at kT ≅ 0.2, 0.7, and 2 keV, respectively, and a circumstellar absorption of ≅0.2 x 10 22 cm -2 . Although the hot plasma component could be indicating the presence of wind-wind collision shocks in the system, the model fluxes calculated from spectral fits, with an average value of ≅7 x 10 -13 erg s -1 cm -2 , do not show a clear correlation with the orbits of the two constituent binaries. A semi-analytical model of QZ Car reveals that a stable momentum balance may not be established in either system A or B. Yet, despite this, system B is expected to produce an observed X-ray flux well in excess of the observations. If one considers the wind of the O8 III star to be disrupted by mass transfer, the model and observations are in far better agreement, which lends support to the previous suggestion of mass transfer in the O8 III + o9 v binary. We conclude that the X-ray emission from QZ Car can be reasonably well accounted for by a combination of contributions mainly from the single stars and the mutual wind-wind collision between systems A and B.

  17. Development and implementation of an automated system to exchange attenuators of the OB85/1 gamma irradiator

    International Nuclear Information System (INIS)

    Silva Junior, Iremar A.; Ramos, Marcio A.G.; Carvalho, Valdir S.; Diniz, Raphael E.; Cescon, Claudinei T.; Vivolo, Vitor; Potiens, Maria da Penha A.

    2011-01-01

    In order to improve the calibration process of portable detectors of the Instrument Calibration Laboratory of IPEN, an automated system to exchange the attenuators of the OB85/1 irradiator system was developed. This automation was developed following this sequence: (i) development of the device with the cooperation of the IPEN Sector of Projects, using the Solid Edge software to design the mechanical part of the exchanging device of the attenuators, in 3D; (ii) simulation with the Festo's FluidSim software to define the pneumatic components and their respective actuators; (iii) machining and assembly of mechanical parts; (iv) assembly of pneumatic components and their actuators, like magnetic pneumatic cylinders, which allow the use of magnetic sensors, used to confirm the attenuators opened or closed positions: actuators 5/2 each, with double solenoid; (v) assembly of the control panel for operating the device remotely from the operating room. With this automation, the technicians in charge of the detectors calibration and research testing will have no hand contact with lead attenuators, improving the calibration process due to the decrease in time spent with manual shift from the attenuators and avoiding accidents, like the fall of the lead attenuators. It has been a concern of the LCI-IPEN group the decrease in the time spent by the technicians in the calibration room controlled areas should follow the recommendations of the radiological protection rules, which recommend the shortest time possible of workers in these areas. Automated systems have, usually, a better rate of reproducibility, due to the small participation by the system operator, so the LCI-IPEN is following the trend of several laboratories and automating its processes. (author)

  18. Association entre le travail par quarts et l’obésité chez les hommes dans le nord-est de l’Ontario

    Directory of Open Access Journals (Sweden)

    Anne Grundy

    2017-01-01

    Full Text Available Introduction : Même si certaines études suggèrent une association entre le travail par quarts et l’obésité, peu sont fondées sur la population ou tiennent compte de divers horaires de travail par quarts. L’obésité étant associée à plusieurs problèmes de santé chroniques, il est important de comprendre quelles formes de travail par quarts ont une incidence sur elle et d’effectuer des travaux permettant d’évaluer de façon plus détaillée l’exposition au travail par quarts. Méthodologie : Au moyen d’une régression logistique polytomique multivariée, nous avons étudié l’association entre le travail par quarts (de soir ou nuit, par quarts ou autre type de rotation et le surpoids et l’obésité, en fonction d’une mesure transversale de l’indice de masse corporelle chez 1 561 hommes. Ces hommes avaient déjà servi de témoins dans une étude cas-témoins sur le cancer de la prostate menée dans le nord-est de l’Ontario de 1995 à 1999. Nous avons obtenu l’information sur leurs antécédents de travail (notamment sur le travail par quarts, leur taille et leur poids à partir de données autodéclarées recueillies par questionnaire. Résultats : Nous avons observé une association entre le fait d’avoir déjà travaillé par quarts (par opposition au fait de n’avoir jamais travaillé par quarts et le surpoids (RC [rapport de cotes] = 1,34; IC [intervalle de confiance] à 95 % : 1,05 à 1,73 ainsi que l’obésité (RC = 1,57; IC à 95 % : 1,12 à 2,21. Nous avons également observé des associations statistiquement non significatives avec le fait d’avoir déjà travaillé (par opposition au fait de n’avoir jamais travaillé de façon permanente selon un quart de soir ou de nuit. Nous avons par ailleurs observé une tendance à la hausse statistiquement significative en ce qui concerne le risque de surpoids et d’obésité en fonction de la durée du travail par quarts. Conclusion : Tant l

  19. THE LATE STAGES OF PROTOPLANETARY DISK EVOLUTION: A MILLIMETER SURVEY OF UPPER SCORPIUS

    International Nuclear Information System (INIS)

    Mathews, Geoffrey S.; Williams, Jonathan P.; Ménard, Francois; Duchêne, Gaspard; Pinte, Christophe; Phillips, Neil

    2012-01-01

    We present deep 1.2 mm photometry of 37 stars in the young (5 Myr) Upper Scorpius OB association, sensitive to ∼4 × 10 –3 M Jup of cool millimeter dust. Disks around four low- and solar-mass stars are detected, as well as one debris disk around an intermediate-mass star, with dust masses ranging from 3.6 × 10 –3 to 1.0 × 10 –1 M Jup . The source with the most massive disk exhibits a transition-disk spectral energy distribution. Combining our results with previous studies, we find that the millimeter-detection fraction of Class II sources has significantly decreased from younger ages, and comparison with near-infrared and Hα measurements indicates that the present disks have undergone significant evolution in composition or structure at all radii. The disks of Upper Scorpius represent the tail-end of the depletion of primordial disks; while a few near-solar-mass stars may still sustain giant planet formation, this process has finished around higher mass stars.

  20. ULTRAVIOLET-SELECTED FIELD AND PRE-MAIN-SEQUENCE STARS TOWARD TAURUS AND UPPER SCORPIUS

    International Nuclear Information System (INIS)

    Findeisen, K.; Hillenbrand, L.

    2010-01-01

    We have carried out a Galaxy Evolution Explorer (GALEX) Cycle 1 guest investigator program covering 56 deg 2 near the Taurus T association and 12 deg 2 along the northern edge of the Upper Scorpius OB association. We combined photometry in the GALEX far-ultraviolet and near-ultraviolet bands with data from the Two Micron All Sky Survey to identify candidate young (∼<100 Myr old) stars as those with an ultraviolet excess relative to older main-sequence stars. Follow-up spectroscopy of a partial sample of these candidates suggests five new members of Taurus, with 8-20 expected from additional observations, and five new members of Upper Scorpius, with three to six expected from additional observations. These candidate new members appear to represent a distributed, non-clustered population in either region, although our sample statistics are as of yet too poor to constrain the nature or extent of this population. Rather, our study demonstrates the ability of GALEX observations to identify young stellar populations distributed over a wide area of the sky. We also highlight the necessity of a better understanding of the Galactic ultraviolet source population to support similar investigations. In particular, we report a large population of stars with an ultraviolet excess but no optical indicators of stellar activity or accretion, and briefly argue against several interpretations of these sources.

  1. Cesium-137 global fallout into the Ob river basin and its influence on the Kara sea contamination - Weapons fallout cesium-137 in the Ob' catchment landscapes and its influence on radioactive contamination of the Kara sea: Western Siberia, Russia

    Energy Technology Data Exchange (ETDEWEB)

    Semenkov, Ivan N.; Miroshnikov, Alexey Yu. [The Organization of Russian Academy of Sciences Institute of geology of ore deposits, petrography, mineralogy and geochemistry Russian Academy of Sciences (Russian Federation)

    2014-07-01

    There are several high level {sup 137}Cs anomaly zones detected in the deposits of the SW part of the Kara Sea. These anomaly zones were formed in the Ob' and the Enisey river estuaries due to the geochemical 'river-sea' boarder barrier. Level of radiocaesium specific activity reaches 120 Bq*kg{sup -1} in the deposits from these zones. Radiochemical enterprises occur in the both river basins. Their activity results in caesium-137 transfer into the river net. Vast area is contaminated by {sup 137}Cs after nuclear weapons in Semipalatinsk test-site and Kyshtym disaster in the Ob' river basin. Moreover, caesium comes to the Ob' and the Enisey river basins with global atmospheric fallout. The inflow of global fallout caesium-137 to the catchments is 660 kCi (320 kCi including radioactive decay) that is 4 times higher than {sup 137}Cs emission due to Fukushima disaster. Therefore, these river basins as any other huge catchment are an important sources of radioactive contamination of the Arctic Ocean. The aim of our research is to study behavior of global fallout caesium-137 in the landscapes of the Ob and the Enisey river basins. We studied caesium-137 behavior on the example of first order catchments in taiga, wetland, forest-steppe, steppe, and semi-arid landscapes. Geographic information system (GIS) was made. The tenth-order catchments (n=154, Horton coding system) shape 20-groups due to topsoil properties controlling cesium mobility. Eleven first-order basins, characterized 7 groups of tenth order catchments, were studied. And 700 bulk-core soil samples were collected in 2011-2013. Cesium runoff is calculated for 3 first-order river basins in taiga and forest-steppe landscapes. Storage of global fallout caesium-137 declines from undisturbing taiga first-order river basin (90% of cumulative fallout including radioactive decay)> arable steppe and fores-steppe (70 - 75%)> undisturbing wetland (60%). Caesium-137 transfer is high in arable lands

  2. The Upper Danube Nature Park

    International Nuclear Information System (INIS)

    Dosedla, H.C.

    1997-01-01

    When in 1980 the Upper Danube Nature Park was founded as one of 65 nature sanctuaries in Germany there was great diversity of opinions concerning its intended character. The protected region consisting of a geologically outstanding landscape within central Europe is covering the first 80 km the upper Danube where the young river shortly after it's source in the Black Forest is breaking through the narrow canyons of the Jurassic rock plateau of the so-called Suebian Alps and also locates the subterranean passage where the stream is submerging from the surface for nearly ten miles. Since the purpose of nature preservation according to German las is closely combined with the rather contradicting aim of offering an attractive recreation area thus facing the immense impacts of modern mass tourism there are numerous problems which in the course of years have resulted in an intricate patterns of subtle management methods coping with the growing awareness of the ecological balance. (author)

  3. Cooperative Hurricane Network Obs

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Observations from the Cooperative Hurricane Reporting Network (CHURN), a special network of stations that provided observations when tropical cyclones approached the...

  4. The OBS control plane

    DEFF Research Database (Denmark)

    Manolova, Anna Vasileva; Ruepp, Sarah Renée

    2010-01-01

    . The applicability analysis carried out here focuses on the actual feasibility of the integration and the potential trade-offs which appear when two contradicting principles are combined. Taking advantage of the flexibility of the GMPLS control plane does not seem to be as easy and as straightforward as expected...

  5. ANCEIOct-ob-er

    Indian Academy of Sciences (India)

    work of Neumark [2], a British aeronautical engineer, which was published as early as 1965, but not ... You have raised a question that I have always been asking me whenever I get the current ... me want to show off their scholarship and assume the readers know the subject. I used to get ... keep myself away. Resonance is ...

  6. Ob padcu utopije

    Directory of Open Access Journals (Sweden)

    Pascal De Decker

    2009-01-01

    Full Text Available Po koncu 2. svetovne vojne so se začele graditi velike stanovanjske soseske. Pogosto so jih sestavljale stolpnice. Številne le 50 let pozneje podirajo oziroma jih temeljito prenavljajo. Modernistične ideje, ki so jih navdihnili predstavniki kongresa CIAM (Congrès International d’Architecture Moderne in Le Corbusier, so izgubile nekdanjo mikavnost. V tem prispevku si bomo ogledali razvoj dogodkov, predvsem pa se bomo posvetili napačni razlagi (simbolnega pomena bivališča, kakor so ga razumeli predstavniki modernističnega gibanja. Prav to napačno razumevanje je nazadnje pripeljalo do hitrega podiranja teh sosesk.

  7. Upper limit of peak area

    International Nuclear Information System (INIS)

    Helene, O.A.M.

    1982-08-01

    The determination of the upper limit of peak area in a multi-channel spectra, with a known significance level is discussed. This problem is specially important when the peak area is masked by the background statistical fluctuations. The problem is exactly solved and, thus, the results are valid in experiments with small number of events. The results are submitted to a Monte Carlo test and applied to the 92 Nb beta decay. (Author) [pt

  8. Upper mantle seismic structure beneath southwest Africa from finite-frequency P- and S-wave tomography

    DEFF Research Database (Denmark)

    Soliman, Mohammad Youssof Ahmad; Yuan, Xiaohui; Tilmann, Frederik

    2015-01-01

    We present a 3D high-resolution seismic model of the southwestern Africa region from teleseismic tomographic inversion of the P- and S- wave data recorded by the amphibious WALPASS network. We used 40 temporary stations in southwestern Africa with records for a period of 2 years (the OBS operated...... for 1 year), between November 2010 and November 2012. The array covers a surface area of approximately 600 by 1200 km and is located at the intersection of the Walvis Ridge, the continental margin of northern Namibia, and extends into the Congo craton. Major questions that need to be understood......, probably related to surficial suture zones and the presence of fertile material. A shallower depth extent of the lithospheric plate of ∼100 km was observed beneath the ocean, consistent with plate-cooling models. In addition to tomographic images, the seismic anisotropy measurements within the upper mantle...

  9. Technology improves upper extremity rehabilitation.

    Science.gov (United States)

    Kowalczewski, Jan; Prochazka, Arthur

    2011-01-01

    Stroke survivors with hemiparesis and spinal cord injury (SCI) survivors with tetraplegia find it difficult or impossible to perform many activities of daily life. There is growing evidence that intensive exercise therapy, especially when supplemented with functional electrical stimulation (FES), can improve upper extremity function, but delivering the treatment can be costly, particularly after recipients leave rehabilitation facilities. Recently, there has been a growing level of interest among researchers and healthcare policymakers to deliver upper extremity treatments to people in their homes using in-home teletherapy (IHT). The few studies that have been carried out so far have encountered a variety of logistical and technical problems, not least the difficulty of conducting properly controlled and blinded protocols that satisfy the requirements of high-level evidence-based research. In most cases, the equipment and communications technology were not designed for individuals with upper extremity disability. It is clear that exercise therapy combined with interventions such as FES, supervised over the Internet, will soon be adopted worldwide in one form or another. Therefore it is timely that researchers, clinicians, and healthcare planners interested in assessing IHT be aware of the pros and cons of the new technology and the factors involved in designing appropriate studies of it. It is crucial to understand the technical barriers, the role of telesupervisors, the motor improvements that participants can reasonably expect and the process of optimizing IHT-exercise therapy protocols to maximize the benefits of the emerging technology. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Improved Mars Upper Atmosphere Climatology

    Science.gov (United States)

    Bougher, S. W.

    2004-01-01

    The detailed characterization of the Mars upper atmosphere is important for future Mars aerobraking activities. Solar cycle, seasonal, and dust trends (climate) as well as planetary wave activity (weather) are crucial to quantify in order to improve our ability to reasonably depict the state of the Mars upper atmosphere over time. To date, our best information is found in the Mars Global Surveyor (MGS) Accelerometer (ACC) database collected during Phase 1 (Ls = 184 - 300; F10.7 = 70 - 90) and Phase 2 (Ls = 30 - 90; F10.7 = 90 - 150) of aerobraking. This database (100 - 170 km) consists of thermospheric densities, temperatures, and scale heights, providing our best constraints for exercising the coupled Mars General Circulation Model (MGCM) and the Mars Thermospheric General Circulation Model (MTGCM). The Planetary Data System (PDS) contains level 0 and 2 MGS Accelerometer data, corresponding to atmospheric densities along the orbit track. Level 3 products (densities, temperatures, and scale heights at constant altitudes) are also available in the PDS. These datasets provide the primary model constraints for the new MGCM-MTGCM simulations summarized in this report. Our strategy for improving the characterization of the Mars upper atmospheres using these models has been three-fold : (a) to conduct data-model comparisons using the latest MGS data covering limited climatic and weather conditions at Mars, (b) to upgrade the 15-micron cooling and near-IR heating rates in the MGCM and MTGCM codes for ad- dressing climatic variations (solar cycle and seasonal) important in linking the lower and upper atmospheres (including migrating tides), and (c) to exercise the detailed coupled MGCM and MTGCM codes to capture and diagnose the planetary wave (migrating plus non-migrating tidal) features throughout the Mars year. Products from this new suite of MGCM-MTGCM coupled simulations are being used to improve our predictions of the structure of the Mars upper atmosphere for the

  11. Star formation history of Canis Major OB1. II. A bimodal X-ray population revealed by XMM-Newton

    Science.gov (United States)

    Santos-Silva, T.; Gregorio-Hetem, J.; Montmerle, T.; Fernandes, B.; Stelzer, B.

    2018-02-01

    Aims: The Canis Major OB1 Association has an intriguing scenario of star formation, especially in the region called Canis Major R1 (CMa R1) traditionally assigned to a reflection nebula, but in reality an ionized region. This work is focussed on the young stellar population associated with CMa R1, for which our previous results from ROSAT, optical, and near-infrared data had revealed two stellar groups with different ages, suggesting a possible mixing of populations originated from distinct star formation episodes. Methods: The X-ray data allow the detected sources to be characterized according to hardness ratios, light curves, and spectra. Estimates of mass and age were obtained from the 2MASS catalogue and used to define a complete subsample of stellar counterparts for statistical purposes. Results: A catalogue of 387 XMM-Newton sources is provided, of which 78% are confirmed as members or probable members of the CMa R1 association. Flares (or similar events) were observed for 13 sources and the spectra of 21 bright sources could be fitted by a thermal plasma model. Mean values of fits parameters were used to estimate X-ray luminosities. We found a minimum value of log(LX [erg/s] ) = 29.43, indicating that our sample of low-mass stars (M⋆ ≤ 0.5 M⊙), which are faint X-ray emitters, is incomplete. Among the 250 objects selected as our complete subsample (defining our "best sample"), 171 are found to the east of the cloud, near Z CMa and dense molecular gas, of which 50% of them are young (10 Myr). The opposite happens to the west, near GU CMa, in areas lacking molecular gas: among 79 objects, 30% are young and 50% are older. These findings confirm that a first episode of distributed star formation occurred in the whole studied region 10 Myr ago and dispersed the molecular gas, while a second, localized episode (<5 Myr) took place in the regions where molecular gas is still present.

  12. The distribution and history of nuclear weapons related contamination in sediments from the Ob River, Siberia as determined by isotopic ratios of plutonium and neptunium

    International Nuclear Information System (INIS)

    Kenna, T.C.; Sayles, F.L.

    2002-01-01

    Isotopic ratios of Pu and Np measured in sediment cores from 5 locations in the Ob River drainage basin show clear evidence of input from sources other than global fallout (non-fallout sources). Historical contaminant records obtained by combining isotopic ratio information with chronological information indicate that non-fallout inputs are from several sources that have varied significantly over the past 50 years. Unique isotopic signatures observed in sediments from tributaries that drain areas containing known or suspected sources of non-fallout contamination are used to identify the source of materials in sediments collected at downstream locations. These data can lead to a better understanding of the transport behavior, fate, and relative importance of particle reactive, weapons related contaminants originating from the nuclear facilities Mayak, Tomsk-7, and Semipalitinsk, which lie within the drainage basin. From our work to date, we draw the following conclusions: (1) Persistent non-fallout contamination is observed in the Ob River above its confluence with the Irtysh River, indicating contamination from the Tomsk-7 facility. (2) Non-fallout contamination in the Tobol River above its confluence with the Irtysh River indicates contamination from the Mayak facility. (3) Non-fallout contamination in the Irtysh River above its confluence with the Tobol River indicates contamination from the Semipalitinsk weapons test site. (4) The occurrence of isotopic ratios in Ob Delta sediments that are similar to those observed in source tributaries suggests that contamination from at least two sources has been transported along the length of the river system. (5) Global fallout, a result of high-yield atmospheric weapons tests conducted by the FSU and USA primarily, is the dominant source of Pu and Np to the region; however, there have been brief periods when inputs from non-fallout sources exceeded those from global fallout

  13. The history and source of particulate 137Cs and 239,240Pu deposition in sediments of the Ob River Delta, Siberia

    International Nuclear Information System (INIS)

    Sayles, F.L.; Livingston, H.D.; Panteleyev, G.P.

    1997-01-01

    This paper presents the first results of a project designed to examine the transfer of particle-associated artificial radionuclides down the Ob River in Siberia to its delta over the past 5 decades. The main sources include fallout from atmospheric nuclear weapons tests and weapons complexes and test sites of the Former Soviet Union in or near the Ob watershed. The approach is to measure the accumulation of the radionuclides in undisturbed delta sediments - obtaining a record of their deposition over time. These records were found in sediments of shallow lakes apart from, and connected to, the main channel. Sediment cores were collected in the summer of 1994 using a shallow draft catamaran to reach these lakes from a support ship in the main channel. Measurements are presented on the depth distributions of 137 Cs and Pu isotopes and their inventories in a series of dated sediment cores - including one from a location in the Taz Estuary (which does not receive Ob River sediments). Sediment dating was carried out using the excess 210 Pb technique. The results obtained are compared with known information on the temporal history of releases from the various sources and characteristics of the isotopic composition of the sources. The results show that good records of radionuclide deposition indicate that the major fraction of 137 Cs and Pu isotopes deposited in these delta sediments comes from atmospheric nuclear weapons test fallout - both delivered directly from the atmosphere and from downstream transport of watershed sediments. No more than 25% of the observed inventories could be derived from other sources

  14. Composites for Exploration Upper Stage

    Science.gov (United States)

    Fikes, J. C.; Jackson, J. R.; Richardson, S. W.; Thomas, A. D.; Mann, T. O.; Miller, S. G.

    2016-01-01

    The Composites for Exploration Upper Stage (CEUS) was a 3-year, level III project within the Technology Demonstration Missions program of the NASA Space Technology Mission Directorate. Studies have shown that composites provide important programmatic enhancements, including reduced weight to increase capability and accelerated expansion of exploration and science mission objectives. The CEUS project was focused on technologies that best advanced innovation, infusion, and broad applications for the inclusion of composites on future large human-rated launch vehicles and spacecraft. The benefits included near- and far-term opportunities for infusion (NASA, industry/commercial, Department of Defense), demonstrated critical technologies and technically implementable evolvable innovations, and sustained Agency experience. The initial scope of the project was to advance technologies for large composite structures applicable to the Space Launch System (SLS) Exploration Upper Stage (EUS) by focusing on the affordability and technical performance of the EUS forward and aft skirts. The project was tasked to develop and demonstrate critical composite technologies with a focus on full-scale materials, design, manufacturing, and test using NASA in-house capabilities. This would have demonstrated a major advancement in confidence and matured the large-scale composite technology to a Technology Readiness Level 6. This project would, therefore, have bridged the gap for providing composite application to SLS upgrades, enabling future exploration missions.

  15. Six upper incisors: what's next?

    Science.gov (United States)

    Berneburg, Mirjam; Meller, Christian

    2016-01-01

    This case report describes our therapeutic approach taken in a girl with eruption disturbance of the upper anterior teeth. Two supernumerary teeth were involved, which required a combination of orthodontic and surgical treatment. The initial situation in the upper anterior segment was characterized by two supernumerary mesial incisors, ectopic eruption of the distally located lateral incisors, and crowded tooth buds in the canine areas. Key decisions had to be made as to whether any teeth needed to be extracted and, if so, regarding the timing and sites of extraction. Removing teeth too early would have preempted a complete assessment of tooth quality, whereas late extraction would have carried a risk of eruption disturbance. Once the distal lateral incisors had erupted, the supernumerary mesial incisors were extracted and the central incisors (initially located in between) mesialized with a bracket appliance. Following space closure and mesialization of the lateral incisors, a functional appliance was used. Tooth 13 was erupting, while tooth 23 was displaced and subsequently aligned as part of the final bracket treatment. To successfully treat eruption disturbances, a careful diagnostic workup is essential, including informative radiographs, personalized treatment planning, and correct decision-making as to whether teeth need to be extracted and regarding the timing and sites of extraction. Finally, the eruption of the canines should be monitored.

  16. ECA&D and E-OBS: High-resolution datasets for monitoring climate change and effects on viticulture in Europe

    Directory of Open Access Journals (Sweden)

    Photiadou Christiana

    2017-01-01

    Full Text Available Climate change and climate variability profoundly affect the production of wine. When facing a changing climate, the characteristics of wine produced in each region will change while the natural year-to-year variations in climate will increase variability of income for wine businesses and therefore affect profitability and economic resilience. The challenge posed to the viticulture community is thus to closely monitor these changes to be able to adapt business practices. The European Climate Assessment and Dataset (ECA&D and its gridded version E-OBS are tools to monitor the changing climatic conditions over Europe, with an emphasis on changes in extreme climatic conditions. In this paper, the potential of ECA&D and E-OBS for viticulture is demonstrated by a few examples. The examples include the changing areal suitable for Chardonnay cultivation, showing an expansion to areas which have been too cold only a few decades ago and retraction of optimal conditions from areas which have been suitable in the recent past. Other examples show the change in the diurnal temperature range in the latter stages of the ripening process of grapes and the variability in heavy precipitation events. Finally, first results of a new dataset for South America are presented.

  17. Acoustic and Shear-Wave Velocities in Hydrate-Bearing Sediments Offshore Southwestern Taiwan: Tomography, Converted Waves Analysis and Reverse-Time Migration of OBS Records

    Directory of Open Access Journals (Sweden)

    Philippe Schnurle

    2006-01-01

    Full Text Available A 2.5-D combined seismic reflection and refraction survey has been conducted in the accretionary complex offshore of southwestern Taiwan where BSRs (Bottom Simulating Reflectors are highly concentrated and geochemical signals for the presence of gas hydrate are strong. In this study, we perform velocity analysis of the 6 4-component OBS (Ocean-Bottom Seismometer records along the southernmost transect of this seismic experiment. We utilize 3 independent methods in order to accurately determine the acoustic and shear-wave velocities of the sediments: 1-D Root Mean Square (RMS analysis of the P-P and P-S reflected events on individual datumed components, 2-D inversion of the P-P and P-S reflected and refracted events along the in-line transect, and 3-D acoustic inversion of the first arrivals. The principal sources of bias in the determination of the velocities are the 3-dimentional nature of the topography and the complexity of the underlying structures. The three methods result in consistent velocity profiles. Rapid lateral and vertical variations of the velocities are observed. We then investigate the large scale gas hydrate content through rock physic modeling: at the vertical of each OBS, shear-waves velocities are utilized to estimate the water-filled porosities, and the acoustic velocities predicted for a set of gas hydrate, quartz and clay contents are compared to the observed profiles.

  18. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    Energy Technology Data Exchange (ETDEWEB)

    Dzib, Sergio A.; Rodriguez, Luis F.; Loinard, Laurent; Ortiz-Leon, Gisela N.; Araudo, Anabella T. [Centro de Radiostronomia y Astrofisica, Universidad Nacional Autonoma de Mexico, Morelia 58089 (Mexico); Mioduszewski, Amy J., E-mail: s.dzib@crya.unam.mx [National Radio Astronomy Observatory, 1003 Lopezville Road, Socorro, NM 87801 (United States)

    2013-02-15

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 {+-} 0.22 mas, corresponding to a distance of 1.65 {sup +0.96} {sub -0.44} kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  19. MULTI-EPOCH VERY LONG BASELINE ARRAY OBSERVATIONS OF THE COMPACT WIND-COLLISION REGION IN THE QUADRUPLE SYSTEM Cyg OB2 no. 5

    International Nuclear Information System (INIS)

    Dzib, Sergio A.; Rodríguez, Luis F.; Loinard, Laurent; Ortiz-León, Gisela N.; Araudo, Anabella T.; Mioduszewski, Amy J.

    2013-01-01

    We present multi-epoch Very Long Base Array observations of the compact wind-collision region in the Cyg OB2 no. 5 system. These observations confirm the arc-shaped morphology of the emission reported earlier. The total flux as a function of time is roughly constant when the source is 'on', but falls below the detection limit as the wind-collision region approaches periastron in its orbit around the contact binary at the center of the system. In addition, at one of the 'on' epochs, the flux drops to about a fifth of its average value. We suggest that this apparent variation could result from the inhomogeneity of the wind that hides part of the flux rather than from an intrinsic variation. We measured a trigonometrical parallax, for the most compact radio emission of 0.61 ± 0.22 mas, corresponding to a distance of 1.65 +0.96 –0.44 kpc, in agreement with recent trigonometrical parallaxes measured for objects in the Cygnus X complex. Using constraints on the total mass of the system and orbital parameters previously reported in the literature, we obtain two independent indirect measurements of the distance to the Cyg OB2 no. 5 system, both consistent with 1.3-1.4 kpc. Finally, we suggest that the companion star responsible for the wind interaction, yet undetected, is of spectral type between B0.5 and O8.

  20. Updates on upper eyelid blepharoplasty

    Directory of Open Access Journals (Sweden)

    Kasturi Bhattacharjee

    2017-01-01

    Full Text Available The human face is composed of small functional and cosmetic units, of which the eyes and periocular region constitute the main point of focus in routine face-to-face interactions. This dynamic region plays a pivotal role in the expression of mood, emotion, and character, thus making it the most relevant component of the facial esthetic and functional unit. Any change in the periocular unit leads to facial imbalance and functional disharmony, leading both the young and the elderly to seek consultation, thus making blepharoplasty the surgical procedure of choice for both cosmetic and functional amelioration. The applied anatomy, indications of upper eyelid blepharoplasty, preoperative workup, surgical procedure, postoperative care, and complications would be discussed in detail in this review article.

  1. Climate of the upper atmosphere

    Directory of Open Access Journals (Sweden)

    Christoph Jacobi

    2009-06-01

    Full Text Available

    In the frame of the European COST 296 project (Mitigation of Ionospheric Effects on Radio Systems, MIERS

    investigations of the climate of the upper atmosphere have been carried out during the last four years to obtain

    new information on the upper atmosphere. Mainly its ionospheric part has been analysed as the ionosphere

    most essential for the propagation of radio waves. Due to collaboration between different European partners

    many new results have been derived in the fields of long-term trends of different ionospheric and related atmospheric

    parameters, the investigations of different types of atmospheric waves and their impact on the ionosphere,

    the variability of the ionosphere, and the investigation of some space weather effects on the ionosphere.


  2. Diagnosis and treatment of upper limb apraxia

    OpenAIRE

    Dovern, A.; Fink, G. R.; Weiss, P. H.

    2012-01-01

    Upper limb apraxia, a disorder of higher motor cognition, is a common consequence of left-hemispheric stroke. Contrary to common assumption, apraxic deficits not only manifest themselves during clinical testing but also have delirious effects on the patients’ everyday life and rehabilitation. Thus, a reliable diagnosis and efficient treatment of upper limb apraxia is important to improve the patients’ prognosis after stroke. Nevertheless, to date, upper limb apraxia is still an underdiagnosed...

  3. Fuzzy upper bounds and their applications

    Energy Technology Data Exchange (ETDEWEB)

    Soleimani-damaneh, M. [Department of Mathematics, Faculty of Mathematical Science and Computer Engineering, Teacher Training University, 599 Taleghani Avenue, Tehran 15618 (Iran, Islamic Republic of)], E-mail: soleimani_d@yahoo.com

    2008-04-15

    This paper considers the concept of fuzzy upper bounds and provides some relevant applications. Considering a fuzzy DEA model, the existence of a fuzzy upper bound for the objective function of the model is shown and an effective approach to solve that model is introduced. Some dual interpretations are provided, which are useful for practical purposes. Applications of the concept of fuzzy upper bounds in two physical problems are pointed out.

  4. Upper plenum mixing in a BWR

    International Nuclear Information System (INIS)

    Alamgir, M.; Andersen, J.G.M.; Parameswaran, V.

    1984-01-01

    A model for the emergency core cooling injection into the upper plenum of a boiling water reactor has been formulated and implemented into the TRACB02 computer program. The model consists of a spray model and a submerged jet model. The submerged jet model is used when the spray nozzles are covered by a two-phase mixture, and the spray model is used when the nozzles are uncovered. The upper plenum model has been assessed by comparison to an upper plenum mixing test in the Steam Sector Test Facility. It is found that the model accurately predicts the phenomena in the upper plenum of a boiling water reactor

  5. Upper gastrointestinal bleeding - state of the art.

    Science.gov (United States)

    Szura, Mirosław; Pasternak, Artur

    2014-01-01

    Upper gastrointestinal (GI) bleeding is a condition requiring immediate medical intervention, with high associated mortality exceeding 10%. The most common cause of upper GI bleeding is peptic ulcer disease, which largely corresponds to the intake of NSAIDs and Helicobacter pylori infection. Endoscopy is the essential tool for the diagnosis and treatment of active upper GI hemorrhage. Endoscopic therapy together with proton pump inhibitors and eradication of Helicobacter pylori significantly reduces rebleeding rates, mortality and number of emergency surgical interventions. This paper presents contemporary data on the diagnosis and treatment of upper gastrointestinal bleeding.

  6. Smartphone supported upper limb prosthesis

    Directory of Open Access Journals (Sweden)

    Hepp D.

    2015-09-01

    Full Text Available State of the art upper limb prostheses offer up to six active DoFs (degrees of freedom and are controlled using different grip patterns. This low number of DoFs combined with a machine-human-interface which does not provide control over all DoFs separately result in a lack of usability for the patient. The aim of this novel upper limb prosthesis is both offering simplified control possibilities for changing grip patterns depending on the patients’ priorities and the improvement of grasp capability. Design development followed the design process requirements given by the European Medical Device Directive 93/42 ECC and was structured into the topics mechanics, software and drive technology. First user needs were identified by literature research and by patient feedback. Consequently, concepts were evaluated against technical and usability requirements. A first evaluation prototype with one active DoF per finger was manufactured. In a second step a test setup with two active DoF per finger was designed. The prototype is connected to an Android based smartphone application. Two main grip patterns can be preselected in the software application and afterwards changed and used by the EMG signal. Three different control algorithms can be selected: “all-day”, “fine” and “tired muscle”. Further parameters can be adjusted to customize the prosthesis to the patients’ needs. First patient feedback certified the prosthesis an improved level of handling compared to the existing devices. Using the two DoF test setup, the possibilities of finger control with a neural network are evaluated at the moment. In a first user feedback test, the smartphone based software application increased the device usability, e.g. the change within preselected grip patterns and the “tired muscle” algorithm. Although the overall software application was positively rated, the handling of the prosthesis itself needs to be proven within a patient study to be

  7. Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain

    Directory of Open Access Journals (Sweden)

    Shanmugam M Jeyakumar

    2016-01-01

    Full Text Available Background & objectives: Hepatic scavenger receptor class B1 (SR-B1, a high-density lipoprotein (HDL receptor, is involved in the selective uptake of HDL-associated esterified cholesterol (EC, thereby regulates cholesterol homoeostasis and improves reverse cholesterol transport. Previously, we reported in euglycaemic obese rats (WNIN/Ob strain that feeding of vitamin A-enriched diet normalized hypercholesterolaemia, possibly through hepatic SR-B1-mediated pathway. This study was aimed to test whether it would be possible to normalize hypercholesterolaemia in glucose-intolerant obese rat model (WNIN/GR/Ob through similar mechanism by feeding identical vitamin A-enriched diet. Methods: In this study, 30 wk old male lean and obese rats of WNIN/GR-Ob strain were divided into two groups and received either stock diet or vitamin A-enriched diet (2.6 mg or 129 mg vitamin A/kg diet for 14 wk. Blood and other tissues were collected for various biochemical analyses. Results: Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized abnormally elevated plasma HDL-cholesterol (HDL-C levels in obese rats as compared to stock diet-fed obese groups. Further, decreased free cholesterol (FC and increased esterified cholesterol (EC contents of plasma cholesterol were observed, which were reflected in higher EC to FC ratio of vitamin A-enriched diet-fed obese rats. However, neither lecithin-cholesterol acyltransferase (LCAT activity of plasma nor its expression (both gene and protein in the liver were altered. On the contrary, hepatic cholesterol levels significantly increased in vitamin A-enriched diet fed obese rats. Hepatic SR-B1 expression (both mRNA and protein remained unaltered among groups. Vitamin A-enriched diet fed obese rats showed a significant increase in hepatic low-density lipoprotein receptor mRNA levels, while the expression of genes involved in HDL synthesis, namely, ATP-binding cassette protein 1 (ABCA1 and

  8. THE BOLOCAM GALACTIC PLANE SURVEY. III. CHARACTERIZING PHYSICAL PROPERTIES OF MASSIVE STAR-FORMING REGIONS IN THE GEMINI OB1 MOLECULAR CLOUD

    International Nuclear Information System (INIS)

    Dunham, Miranda K.; Evans, Neal J.; Harvey, Paul; Merello, Manuel; Rosolowsky, Erik; Cyganowski, Claudia J.; Aguirre, James; Bally, John; Battersby, Cara; Ginsburg, Adam; Glenn, Jason; Stringfellow, Guy S.; Bradley, Eric Todd; Dowell, Darren; Drosback, Meredith; Schlingman, Wayne; Shirley, Yancy L.; Walawender, Josh; Williams, Jonathan P.

    2010-01-01

    We present the 1.1 mm Bolocam Galactic Plane Survey (BGPS) observations of the Gemini OB1 molecular cloud complex, and targeted NH 3 observations of the BGPS sources. When paired with molecular spectroscopy of a dense gas tracer, millimeter observations yield physical properties such as masses, radii, mean densities, kinetic temperatures, and line widths. We detect 34 distinct BGPS sources above 5σ = 0.37 Jy beam -1 with corresponding 5σ detections in the NH 3 (1,1) transition. Eight of the objects show water maser emission (20%). We find a mean millimeter source FWHM of 1.12 pc and a mean gas kinetic temperature of 20 K for the sample of 34 BGPS sources with detections in the NH 3 (1,1) line. The observed NH 3 line widths are dominated by non-thermal motions, typically found to be a few times the thermal sound speed expected for the derived kinetic temperature. We calculate the mass for each source from the millimeter flux assuming the sources are isothermal and find a mean isothermal mass within a 120'' aperture of 230 ± 180 M sun . We find a total mass of 8400 M sun for all BGPS sources in the Gemini OB1 molecular cloud, representing 6.5% of the cloud mass. By comparing the millimeter isothermal mass to the virial mass calculated from the NH 3 line widths within a radius equal to the millimeter source size, we find a mean virial parameter (M vir /M iso ) of 1.0 ± 0.9 for the sample. We find mean values for the distributions of column densities of 1.0 x 10 22 cm -2 for H 2 , and 3.0 x 10 14 cm -2 for NH 3 , giving a mean NH 3 abundance of 3.0 x 10 -8 relative to H 2 . We find volume-averaged densities on the order of 10 3 -10 4 cm -3 . The sizes and densities suggest that in the Gem OB1 region the BGPS is detecting the clumps from which stellar clusters form, rather than smaller, higher density cores where single stars or small multiple systems form.

  9. High-Resolution Infrared Spectroscopic Observations of the Upper Scorpius Eclipsing Binary EPIC 203868608

    Science.gov (United States)

    Johnson, Marshall C.; Mace, Gregory N.; Kim, Hwihyun; Kaplan, Kyle; McLane, Jacob; Sokal, Kimberly R.

    2017-06-01

    EPIC 203868608 is a source in the ~10 Myr old Upper Scorpius OB association. Using K2 photometry and ground-based follow-up observations, David et al. (2016) found that it consists of two brown dwarfs with a tertiary object at a projected separation of ~20 AU; the former objects appear to be a double-lined eclipsing binary with a period of 4.5 days. This is one of only two known eclipsing SB2s where both components are below the hydrogen-burning limit. We present additional follow-up observations of this system from the IGRINS high-resolution near-infrared spectrograph at McDonald Observatory. Our measured radial velocities do not follow the orbital solution presented by David et al. (2016). Instead, our combined IGRINS plus literature radial velocity dataset appears to indicate a period significantly different than that of the eclipsing binary obvious from the K2 light curve. We will discuss possible scenarios to account for the conflicting observations of this system.

  10. Report from upper atmospheric science

    International Nuclear Information System (INIS)

    Carignan, G.R.; Roble, R.G.; Mende, S.B.; Nagy, A.F.; Hudson, R.D.

    1989-01-01

    Most of the understanding of the thermosphere resulted from the analysis of data accrued through the Atmosphere Explorer satellites, the Dynamics Explorer 2 satellite, and observations from rockets, balloons, and ground based instruments. However, new questions were posed by the data that have not yet been answered. The mesosphere and lower thermosphere have been less thoroughly studied because of the difficulty of accessibility on a global scale, and many rather fundamental characteristics of these regions are not well understood. A wide variety of measurement platforms can be used to implement various parts of a measurement strategy, but the major thrusts of the International Solar Terrestrial Physics Program would require Explorer-class missions. A remote sensing mission to explore the mesosphere and lower thermosphere and one and two Explorer-type spacecraft to enable a mission into the thermosphere itself would provide the essential components of a productive program of exploration of this important region of the upper atomsphere. Theoretical mission options are explored

  11. Upper gastrointestinal bleeding in patients with CKD.

    Science.gov (United States)

    Liang, Chih-Chia; Wang, Su-Ming; Kuo, Huey-Liang; Chang, Chiz-Tzung; Liu, Jiung-Hsiun; Lin, Hsin-Hung; Wang, I-Kuan; Yang, Ya-Fei; Lu, Yueh-Ju; Chou, Che-Yi; Huang, Chiu-Ching

    2014-08-07

    Patients with CKD receiving maintenance dialysis are at risk for upper gastrointestinal bleeding. However, the risk of upper gastrointestinal bleeding in patients with early CKD who are not receiving dialysis is unknown. The hypothesis was that their risk of upper gastrointestinal bleeding is negatively linked to renal function. To test this hypothesis, the association between eGFR and risk of upper gastrointestinal bleeding in patients with stages 3-5 CKD who were not receiving dialysis was analyzed. Patients with stages 3-5 CKD in the CKD program from 2003 to 2009 were enrolled and prospectively followed until December of 2012 to monitor the development of upper gastrointestinal bleeding. The risk of upper gastrointestinal bleeding was analyzed using competing-risks regression with time-varying covariates. In total, 2968 patients with stages 3-5 CKD who were not receiving dialysis were followed for a median of 1.9 years. The incidence of upper gastrointestinal bleeding per 100 patient-years was 3.7 (95% confidence interval, 3.5 to 3.9) in patients with stage 3 CKD, 5.0 (95% confidence interval, 4.8 to 5.3) in patients with stage 4 CKD, and 13.9 (95% confidence interval, 13.1 to 14.8) in patients with stage 5 CKD. Higher eGFR was associated with a lower risk of upper gastrointestinal bleeding (P=0.03), with a subdistribution hazard ratio of 0.93 (95% confidence interval, 0.87 to 0.99) for every 5 ml/min per 1.73 m(2) higher eGFR. A history of upper gastrointestinal bleeding (Pupper gastrointestinal bleeding risk. In patients with CKD who are not receiving dialysis, lower renal function is associated with higher risk for upper gastrointestinal bleeding. The risk is higher in patients with previous upper gastrointestinal bleeding history and low serum albumin. Copyright © 2014 by the American Society of Nephrology.

  12. Gels and gel-derived glasses in the Na2O-B2O3-SiO2 system. [containerless melting in space

    Science.gov (United States)

    Mukherjee, S. P.

    1982-01-01

    The containerless melting of high-purity multicomponent homogeneous gels and gel-monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the Na2O-B2O3-SiO2 system are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures were found to be significantly different. IR absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel-monoliths to transparent 'glass' without melting are described.

  13. Gels and gel-derived glasses in the system Na2O-B2O3-SiO2

    Science.gov (United States)

    Mukherjee, S. P.

    1983-01-01

    The containerless melting of high-purity multicomponent homogeneous gels and gel monoliths offers a unique approach to making ultrapure multicomponent optical glasses in the reduced gravity environment of space. Procedures for preparing and characterizing gels and gel-derived glasses in the system Na2O-B2O3-SiO2 are described. Preparation is based on the polymerization reactions of alkoxysilane with trimethyl borate or boric acid and a suitable sodium compound. The chemistry of the gelling process is discussed in terms of process parameters and the gel compositions. The physicochemical nature of gels prepared by three different procedures was found to be significantly different. Infrared absorption spectra indicate finite differences in the molecular structures of the different gels. The melting of the gel powders and the transformation of porous gel monoliths to transparent 'glass' without melting are described.

  14. Unsedated Flexible Upper Gastrointestinal Endoscopy: Need for ...

    African Journals Online (AJOL)

    Background: To determine the incidence of oxygen desaturation and whether routine oxygen monitoring is necessary during unsedated diagnostic flexible upper gastrointestinal endoscopy. Methods: A prospective study involving 54 consecutive in and out patients who had diagnostic upper gastrointestinal endoscopy at ...

  15. Upper High School Students' Understanding of Electromagnetism

    Science.gov (United States)

    Saglam, Murat; Millar, Robin

    2006-01-01

    Although electromagnetism is an important component of upper secondary school physics syllabuses in many countries, there has been relatively little research on students' understanding of the topic. A written test consisting of 16 diagnostic questions was developed and used to survey the understanding of electromagnetism of upper secondary school…

  16. A Boundary Property for Upper Domination

    KAUST Repository

    AbouEisha, Hassan M.; Hussain, Shahid; Lozin, Vadim; Monnot, Jé rô me; Ries, Bernard; Zamaraev, Viktor

    2016-01-01

    An upper dominating set in a graph is a minimal (with respect to set inclusion) dominating set of maximum cardinality.The problem of finding an upper dominating set is generally NP-hard, but can be solved in polynomial time in some restricted graph

  17. The Upper Atmosphere; Threshold of Space.

    Science.gov (United States)

    Bird, John

    This booklet contains illustrations of the upper atmosphere, describes some recent discoveries, and suggests future research questions. It contains many color photographs. Sections include: (1) "Where Does Space Begin?"; (2) "Importance of the Upper Atmosphere" (including neutral atmosphere, ionized regions, and balloon and investigations); (3)…

  18. DUST PROPERTIES AND DISK STRUCTURE OF EVOLVED PROTOPLANETARY DISKS IN Cep OB2: GRAIN GROWTH, SETTLING, GAS AND DUST MASS, AND INSIDE-OUT EVOLUTION

    International Nuclear Information System (INIS)

    Sicilia-Aguilar, Aurora; Henning, Thomas; Dullemond, Cornelis P.; Bouwman, Jeroen; Sturm, Bernhard; Patel, Nimesh; Juhász, Attila

    2011-01-01

    We present Spitzer/Infrared Spectrograph spectra of 31 T Tauri stars (TTS) and IRAM/1.3 mm observations for 34 low- and intermediate-mass stars in the Cep OB2 region. Including our previously published data, we analyze 56 TTS and 3 intermediate-mass stars with silicate features in Tr 37 (∼4 Myr) and NGC 7160 (∼12 Myr). The silicate emission features are well reproduced with a mixture of amorphous (with olivine, forsterite, and silica stoichiometry) and crystalline grains (forsterite, enstatite). We explore grain size and disk structure using radiative transfer disk models, finding that most objects have suffered substantial evolution (grain growth, settling). About half of the disks show inside-out evolution, with either dust-cleared inner holes or a radially dependent dust distribution, typically with larger grains and more settling in the innermost disk. The typical strong silicate features nevertheless require the presence of small dust grains, and could be explained by differential settling according to grain size, anomalous dust distributions, and/or optically thin dust populations within disk gaps. M-type stars tend to have weaker silicate emission and steeper spectral energy distributions than K-type objects. The inferred low dust masses are in a strong contrast with the relatively high gas accretion rates, suggesting global grain growth and/or an anomalous gas-to-dust ratio. Transition disks in the Cep OB2 region display strongly processed grains, suggesting that they are dominated by dust evolution and settling. Finally, the presence of rare but remarkable disks with strong accretion at old ages reveals that some very massive disks may still survive to grain growth, gravitational instabilities, and planet formation.

  19. Extended Gamma-Ray Emission from the G25.0+0.0 Region: A Star-forming Region Powered by the Newly Found OB Association?

    Energy Technology Data Exchange (ETDEWEB)

    Katsuta, J. [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Uchiyama, Y. [Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501 (Japan); Funk, S., E-mail: katsuta@hep01.hepl.hiroshima-u.ac.jp [Erlangen Centre for Astroparticle Physics, D-91058 Erlangen (Germany)

    2017-04-20

    We report a study of extended γ -ray emission with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope , which is likely to be the second case of a γ -ray detection from a star-forming region (SFR) in our Galaxy. The LAT source is located in the G25 region, 1.°7 × 2.°1 around ( l , b ) = (25.°0, 0.°0). The γ -ray emission is found to be composed of two extended sources and one pointlike source. The extended sources have similar sizes of about 1.°4 × 0.°6. An ∼0.°4 diameter subregion of one has a photon index of Γ = 1.53 ± 0.15, and is spatially coincident with HESS J1837−069, likely a pulsar wind nebula. The other parts of the extended sources have a photon index of Γ = 2.1 ± 0.2 without significant spectral curvature. Given their spatial and spectral properties, they have no clear associations with sources at other wavelengths. Their γ -ray properties are similar to those of the Cygnus cocoon SFR, the only firmly established γ -ray detection of an SFR in the Galaxy. Indeed, we find bubble-like structures of atomic and molecular gas in G25, which may be created by a putative OB association/cluster. The γ -ray emitting regions appear confined in the bubble-like structure; similar properties are also found in the Cygnus cocoon. In addition, using observations with the XMM-Newton , we find a candidate young massive OB association/cluster G25.18+0.26 in the G25 region. We propose that the extended γ -ray emission in G25 is associated with an SFR driven by G25.18+0.26. Based on this scenario, we discuss possible acceleration processes in the SFR and compare them with the Cygnus cocoon.

  20. Delaware River and Upper Bay Sediment Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The area of coverage consists of 192 square miles of benthic habitat mapped from 2005 to 2007 in the Delaware River and Upper Delaware Bay. The bottom sediment map...

  1. Climate influences on upper Limpopo River flow

    African Journals Online (AJOL)

    2016-01-01

    Jan 1, 2016 ... Keywords: Limpopo Valley, hydro-meteorology, surface water deficit. * To whom all ... millenia and there is a history of drought impacts on vegetation. (Ekblom et ... water budget of the upper Limpopo River valley using direct.

  2. γ -phlebography of the upper limbs

    International Nuclear Information System (INIS)

    Jacolot, G.; Legendre, P.; Millour, L.; Barra, J.A.; Perramant, M.; Morin, P.P.

    1981-01-01

    γ-phlebography is an easy and repetitive exploration of deep venous thrombosis. This investigation becomes very useful for the upper limbs on account of the present frequency of iatrogenic thrombosis [fr

  3. Lathlike upper bainite in a silicon steel

    International Nuclear Information System (INIS)

    Liu Cheng; Zhao Zhenbo; Bhole, S.D.

    2006-01-01

    The morphology and mechanical properties of upper bainite formed isothermally at 400 deg. C for different holding times in a 1.83 wt.% silicon steel have been investigated by optical metallograph, X-ray diffraction and transmission electron microscopy (TEM). In the early stage of upper bainitic transformation, lathlike bainite whose individual lath ferrite is separated by the thin film type of retained austenite is obtained. As the isothermal holding times are increased, the blocky region consisting of retained austenite and martensite is also found. The stability of retained austenite in lathlike upper bainite is studied in relation to the isothermal treatment times, and the heat treatment conditions. The results show that an optimum combination of strength and ductility is attributed to the formation of bainitic ferrite (BF) and a large amount of thin film carbon-enriched retained austenite in the upper bainite

  4. upper gastrointestinal endoscopy findings in patients referred

    African Journals Online (AJOL)

    2014-08-01

    Aug 1, 2014 ... Objective: To determine the pattern of referral and endoscopy ... build a model of a flexible fibre imaging device (2) ..... a retrospective and prospective audit of all upper ... endoscopy should be reserved for the high risk.

  5. Parametric decay below the upper hybrid frequency

    Energy Technology Data Exchange (ETDEWEB)

    Albers, E; Krause, K; Schlueter, H [Bochum Univ. (Germany, F.R.). Inst. fuer Experimentalphysik 2

    1977-03-21

    Parametric decay of the upper hybrid mode is observed between the electron cyclotron frequency and its first two harmonics. The decay products are identified as electron Bernstein and ion acoustic mode. The diagnostic results confirm the relevant dispersion relations.

  6. An approach to the painful upper limb

    African Journals Online (AJOL)

    Pain in the upper limb is a common presenting complaint in the primary health care setting and the ... disruptions or pathological fracture, as opposed to ... and a neurological assessment of the lower limbs. This is in addition to a thorough.

  7. CASE STUDY CRITIQUE; UPPER CLINCH CASE STUDY

    Science.gov (United States)

    Case study critique: Upper Clinch case study (from Research on Methods for Integrating Ecological Economics and Ecological Risk Assessment: A Trade-off Weighted Index Approach to Integrating Economics and Ecological Risk Assessment). This critique answers the questions: 1) does ...

  8. Appropriateness of Referrals for Upper Gastrointestinal Endoscopy ...

    African Journals Online (AJOL)

    Appropriateness of Referrals for Upper Gastrointestinal Endoscopy. ... Accra between January and December, 2008 were interviewed and evaluated for this study. ... Presentations with bleeding and suspicion of malignancy showed statistical ...

  9. Endometrioid carcinoma of the upper urinary tract

    Directory of Open Access Journals (Sweden)

    Kulkarni Jagdeesh

    2010-01-01

    Full Text Available Herein, we report a second case of endometrioid carcinoma of the upper urinary tract presenting 17 years after hysterectomy for high grade adenocarcinoma of ovary. A 51-year-old nullipara presented to us with a complaint of hematuria. After complete work up, she underwent right radical nephro-ureterectomy with bladder cuff excision. The histology showed endometrioid carcinoma of upper urinary tract without any evidence of endometriosis.

  10. Upper gastrointestinal alterations in kidney transplant candidates.

    Science.gov (United States)

    Homse Netto, João Pedro; Pinheiro, João Pedro Sant'Anna; Ferrari, Mariana Lopes; Soares, Mirella Tizziani; Silveira, Rogério Augusto Gomes; Maioli, Mariana Espiga; Delfino, Vinicius Daher Alvares

    2018-05-14

    The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts. The data collected from the patients' medical records were charted on Microsoft Office Excel 2016 and presented descriptively. Mean values, medians, interquartile ranges and 95% confidence intervals of the clinic and epidemiological variables were calculated. Possible associations between endoscopic findings and infection by H. pylori were studied. Males accounted for 54.17% of the 96 patients included in the study. Median age and time on dialysis were 50 years and 50 months, respectively. The most frequent upper endoscopy finding was enanthematous pangastritis (57.30%), followed by erosive esophagitis (30.20%). Gastric intestinal metaplasia and peptic ulcer were found in 8.33% and 7.30% of the patients, respectively. H. pylori tests were positive in 49 patients, and H. pylori infection was correlated only with non-erosive esophagitis (P = 0.046). Abnormal upper endoscopy findings were detected in all studied patients. This study suggested that upper endoscopy is a valid procedure for kidney transplant candidates. However, prospective studies are needed to shed more light on this matter.

  11. Knowledge, Attitudes, and Reported Practices Among Obstetrician-Gynecologists in the USA Regarding Antibiotic Prescribing for Upper Respiratory Tract Infections

    Directory of Open Access Journals (Sweden)

    Shadi Chamany

    2005-01-01

    determining whether an OB/GYN-specific program promoting appropriate antibiotic use would significantly contribute to the efforts to decrease inappropriate antibiotic use among primary care providers.

  12. ON COMPUTING UPPER LIMITS TO SOURCE INTENSITIES

    International Nuclear Information System (INIS)

    Kashyap, Vinay L.; Siemiginowska, Aneta; Van Dyk, David A.; Xu Jin; Connors, Alanna; Freeman, Peter E.; Zezas, Andreas

    2010-01-01

    A common problem in astrophysics is determining how bright a source could be and still not be detected in an observation. Despite the simplicity with which the problem can be stated, the solution involves complicated statistical issues that require careful analysis. In contrast to the more familiar confidence bound, this concept has never been formally analyzed, leading to a great variety of often ad hoc solutions. Here we formulate and describe the problem in a self-consistent manner. Detection significance is usually defined by the acceptable proportion of false positives (background fluctuations that are claimed as detections, or Type I error), and we invoke the complementary concept of false negatives (real sources that go undetected, or Type II error), based on the statistical power of a test, to compute an upper limit to the detectable source intensity. To determine the minimum intensity that a source must have for it to be detected, we first define a detection threshold and then compute the probabilities of detecting sources of various intensities at the given threshold. The intensity that corresponds to the specified Type II error probability defines that minimum intensity and is identified as the upper limit. Thus, an upper limit is a characteristic of the detection procedure rather than the strength of any particular source. It should not be confused with confidence intervals or other estimates of source intensity. This is particularly important given the large number of catalogs that are being generated from increasingly sensitive surveys. We discuss, with examples, the differences between these upper limits and confidence bounds. Both measures are useful quantities that should be reported in order to extract the most science from catalogs, though they answer different statistical questions: an upper bound describes an inference range on the source intensity, while an upper limit calibrates the detection process. We provide a recipe for computing upper

  13. Multiphase formation of the Obří důl polymetallic skarn deposit, West Sudetes, Bohemian Massif: geochemistry and Re-Os dating of sulfide mineralization

    Science.gov (United States)

    Veselovský, František; Ackerman, Lukáš; Pašava, Jan; Žák, Karel; Haluzová, Eva; Creaser, Robert A.; Dobeš, Petr; Erban, Vojtěch; Tásler, Radko

    2018-06-01

    The Obří důl Fe-Cu-As polymetallic sulfide skarn deposit is developed in a metamorphic series in the West Sudetes, Bohemian Massif. It consists of lenses of marble, calc-silicate rocks, and skarns. We studied the Gustav orebody, which is located few hundred meters away from the contact with a large, late-orogenic Variscan Krkonoše-Jizera Plutonic Complex (KJPC) emplaced into shallow crust. Mineralogical and fluid inclusion study evidence indicates that the main sulfide stage, dominated by pyrrhotite, arsenopyrite, and chalcopyrite originated from aqueous hydrothermal fluids with salinity up to 8 wt% NaCl eq. with minimum homogenization temperatures ranging from 324 to 358 °C. These fluids mainly replaced carbonate-rich lithologies. Carbon, oxygen, and strontium isotope data in Ca-rich rocks imply total overprinting by channelized metasomatic fluid flow, which is most probably related to the intrusion of the KJPC, whereas δ34S values of sulfides argue for a magmatic source of sulfur. The Re-Os age of arsenopyrite overlaps published age data for the KJPC and suggests synchronous formation of the main sulfide mineralization and pluton emplacement.

  14. NEAR-INFRARED PERIODIC AND OTHER VARIABLE FIELD STARS IN THE FIELD OF THE CYGNUS OB7 STAR-FORMING REGION

    Energy Technology Data Exchange (ETDEWEB)

    Wolk, Scott J.; Rice, Thomas S. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Aspin, Colin A. [Institute for Astronomy, University of Hawaii at Manoa, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2013-04-15

    We present a subset of the results of a three-season, 124 night, near-infrared monitoring campaign of the dark clouds Lynds 1003 and Lynds 1004 in the Cygnus OB7 star-forming region. In this paper, we focus on the field star population. Using three seasons of UKIRT J, H, and K-band observations spanning 1.5 years, we obtained high-quality photometry on 9200 stars down to J = 17 mag, with photometric uncertainty better than 0.04 mag. After excluding known disk-bearing stars we identify 149 variables-1.6% of the sample. Of these, about 60 are strictly periodic, with periods predominantly <2 days. We conclude this group is dominated by eclipsing binaries. A few stars have long period signals of between 20 and 60 days. About 25 stars have weak modulated signals, but it was not clear if these were periodic. Some of the stars in this group may be diskless young stellar objects with relatively large variability due to cool starspots. The remaining {approx}60 stars showed variations which appear to be purely stochastic.

  15. Structural study of Na2O-B2O3-SiO2 glasses from molecular simulations using a polarizable force field.

    Science.gov (United States)

    Pacaud, Fabien; Delaye, Jean-Marc; Charpentier, Thibault; Cormier, Laurent; Salanne, Mathieu

    2017-10-28

    Sodium borosilicate glasses Na 2 O-B 2 O 3 -SiO 2 (NBS) are complex systems from a structural point of view. Three main building units are present: tetrahedral SiO 4 and BO 4 (B IV ) and triangular BO 3 (B III ). One of the salient features of these compounds is the change of the B III /B IV ratio with the alkali concentration, which is very difficult to capture in force fields-based molecular dynamics simulations. In this work, we develop a polarizable force field that is able to reproduce the boron coordination and more generally the structure of several NBS systems in the glass and in the melt. The parameters of the potential are fitted from density functional theory calculations only, in contrast with the existing empirical potentials for NBS systems. This ensures a strong improvement on the transferability of the parameters from one composition to another. Using this new force field, the structure of NBS systems is validated against neutron diffraction and nuclear magnetic resonance experiments. A special focus is given to the distribution of B III /B IV with respect to the composition and the temperature.

  16. Interventional studies of the upper gastrointestinal tract

    International Nuclear Information System (INIS)

    Shapiro, B.; Gross, M.D.

    1985-01-01

    Nuclear Medicine studies of the upper gastrointestinal (GI) tract provide a means whereby physiologic and pathophysiologic features can be observed from a unique and noninvasive perspective. While nuclear medicine studies by their very nature lack the high spatial resolution of the radiographic approach, the data derived are readily quantitated and presented in numerical fashion to provide functional and dynamic information in which the influences of interventions may be observed. This chapter outlines the scope of such interventions in studies of the upper GI tract with emphasis on examinations for gastroesophageal reflux and gastric emptying. The interactions of nutrients, physical maneuvers of pharmacologic agents on nuclear medicine studies of the upper GI tract may be intentional to render a test more sensitive or to evaluate the effect of therapy, or may represent an unintentional side effect that must be taken into account if misinterpretation is to be avoided

  17. Upper limb treatment technigues for stroke survivors

    Directory of Open Access Journals (Sweden)

    Martyna Kornet

    2017-03-01

    It was considered that the most important elements of the treatment used in the rehabilitation of the paretic upper limb are: exercise matching the anti-spasm pattern, maintaining appropriate position for exercise that provide an approximation of the shoulder joint and the use of cross-facilitation. The study indicates that the treatment of a post stroke upper limb should be based on the: physiotherapy, kinesiotherapy and specific positioning - all of them corresponding to a given stage of the disease. The work also presents the most frequently used methods, especially highlighting: the Prorioceptive Neuromuscular Facilitation (PNF, Bobath, Brunnstrom, CIMT and OIT. It was also shown that in order to enhance the effects of a post-stroke upper limb rehabilitation, it should be extended by modern methods such as Mirror Therapy, Virtual Reality or Robot-assisted Therapy.

  18. Upper entropy axioms and lower entropy axioms

    International Nuclear Information System (INIS)

    Guo, Jin-Li; Suo, Qi

    2015-01-01

    The paper suggests the concepts of an upper entropy and a lower entropy. We propose a new axiomatic definition, namely, upper entropy axioms, inspired by axioms of metric spaces, and also formulate lower entropy axioms. We also develop weak upper entropy axioms and weak lower entropy axioms. Their conditions are weaker than those of Shannon–Khinchin axioms and Tsallis axioms, while these conditions are stronger than those of the axiomatics based on the first three Shannon–Khinchin axioms. The subadditivity and strong subadditivity of entropy are obtained in the new axiomatics. Tsallis statistics is a special case of satisfying our axioms. Moreover, different forms of information measures, such as Shannon entropy, Daroczy entropy, Tsallis entropy and other entropies, can be unified under the same axiomatics

  19. Upper mantle flow in the western Mediterranean

    Energy Technology Data Exchange (ETDEWEB)

    Panza, G F [Dipartimento di Scienze della Terra, Universita degli Studi di Trieste, Trieste (Italy) and Abdus Salam International Centre for Theoretical Physics, Trieste (Italy); Raykova, R [Geophysical Institute of BAS, Sofia (Bulgaria) and Istituto Nazionale di Geofisica e Vulcanologia, Sezione Bologna, Bologna (Italy); Carminati, E; Doglioni, C [Dipartimento di Scienze della Terra, Universita degli Studi di Trieste, Trieste (Italy)

    2006-07-15

    Two cross-sections of the western Mediterranean Neogene-to-present backarc basin are presented, in which geological and geophysical data of the Transmed project are tied to a new shear-wave tomography. Major results are i) the presence of a well stratified upper mantle beneath the older African continent, with a marked low-velocity layer between 130-200 km of depth; ii) the dilution of this layer within the younger western Mediterranean backarc basin to the north, and iii) the easterly raising of a shallower low-velocity layer from about 140 km to about 30 km in the Tyrrhenian active part of the backarc basin. These findings suggest upper mantle circulation in the western Mediterranean backarc basin, mostly easterly-directed and affecting the boundary between upper asthenosphere (LVZ) and lower asthenosphere, which undulates between about 180 km and 280 km. (author)

  20. Upper mantle flow in the western Mediterranean

    International Nuclear Information System (INIS)

    Panza, G.F.; Raykova, R.; Carminati, E.; Doglioni, C.

    2006-07-01

    Two cross-sections of the western Mediterranean Neogene-to-present backarc basin are presented, in which geological and geophysical data of the Transmed project are tied to a new shear-wave tomography. Major results are i) the presence of a well stratified upper mantle beneath the older African continent, with a marked low-velocity layer between 130-200 km of depth; ii) the dilution of this layer within the younger western Mediterranean backarc basin to the north, and iii) the easterly raising of a shallower low-velocity layer from about 140 km to about 30 km in the Tyrrhenian active part of the backarc basin. These findings suggest upper mantle circulation in the western Mediterranean backarc basin, mostly easterly-directed and affecting the boundary between upper asthenosphere (LVZ) and lower asthenosphere, which undulates between about 180 km and 280 km. (author)

  1. A Boundary Property for Upper Domination

    KAUST Repository

    AbouEisha, Hassan M.

    2016-08-08

    An upper dominating set in a graph is a minimal (with respect to set inclusion) dominating set of maximum cardinality.The problem of finding an upper dominating set is generally NP-hard, but can be solved in polynomial time in some restricted graph classes, such as P4-free graphs or 2K2-free graphs.For classes defined by finitely many forbidden induced subgraphs, the boundary separating difficult instances of the problem from polynomially solvable ones consists of the so called boundary classes.However, none of such classes has been identified so far for the upper dominating set problem.In the present paper, we discover the first boundary class for this problem.

  2. Transfusion strategy for acute upper gastrointestinal bleeding.

    Science.gov (United States)

    Handel, James; Lang, Eddy

    2015-09-01

    Clinical question Does a hemoglobin transfusion threshold of 70 g/L yield better patient outcomes than a threshold of 90 g/L in patients with acute upper gastrointestinal bleeding? Article chosen Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013;368(1):11-21. Study objectives The authors of this study measured mortality, from any cause, within the first 45 days, in patients with acute upper gastrointestinal bleeding, who were managed with a hemoglobin threshold for red cell transfusion of either 70 g/L or 90 g/L. The secondary outcome measures included rate of further bleeding and rate of adverse events.

  3. Hypnosis and upper digestive function and disease

    Science.gov (United States)

    Chiarioni, Giuseppe; Palsson, Olafur S; Whitehead, William E

    2008-01-01

    Hypnosis is a therapeutic technique that primarily involves attentive receptive concentration. Even though a small number of health professionals are trained in hypnosis and lingering myths and misconceptions associated with this method have hampered its widespread use to treat medical conditions, hypnotherapy has gained relevance as an effective treatment for irritable bowel syndrome not responsive to standard care. More recently, a few studies have addressed the potential influence of hypnosis on upper digestive function and disease. This paper reviews the efficacy of hypnosis in the modulation of upper digestive motor and secretory function. The present evidence of the effectiveness of hypnotherapy as a treatment for functional and organic diseases of the upper bowel is also summarized, coupled with a discussion of potential mechanisms of its therapeutic action. PMID:19009639

  4. Membraneous stenosis of the upper oesophagus ('webs')

    International Nuclear Information System (INIS)

    Koch, H.L.; Kurtz, B.

    1981-01-01

    Webs of the upper oesophagus are sail-like mucosal folds of unknown aetiology. Small, transverse webs on the anterior wall of the oesophagus are not uncommon incidental findings which are easily overlooked on routine examination. Extensive, circular membranes in the upper oesophagus, on the other hand, are rare; these may lead to severe difficulty with swallowing and may be associated with regurgitation. One example of a transverse, and three cases of circular webs are described, which caused stenosis and dysphagia and which, in some cases, were multiple. The aetiology is discussed. (orig.) [de

  5. Information Literacy in the Upper Secondary School

    DEFF Research Database (Denmark)

    Holm, Claus; Schreiber, Trine; Tønnesen, Pia Hvid

    The discussion paper is a publication from the project Information Literacy in the Upper Secondary School. The project is a collaboration between the National Library of Education at the Danish School of Education, Aarhus University, and the Royal School of Library and Information Science....... The project is funded by Denmark's Electronic Research Library (DEFF). The discussion paper is published in connection with the conference Information Literacy in the Upper Secondary School on 22 April 2010. See video streaming from the conference etc. at www.dpu.dk/info....

  6. Collaborative Tools in Upper Secondary School - Why?

    DEFF Research Database (Denmark)

    Mathiasen, Helle; Degn, Hans-Peter; Bech, Christian Winther

    2013-01-01

    The paper will discuss potentials of digital media to support student engagement and student production in Danish upper secondary education with a specific focus on group work and collaboration. With the latest school reform, upper secondary education in Denmark has experienced an increased focus...... on the system theoretical approach will be described. Third, the findings from the qualitative, and quantitative studies will be presented. The paper concludes that the study demonstrates changes in the way group work is organised by the students using digital media, and a tendency to develop student engagement...

  7. The current content of artificial radionuclides in the water of the Tobol-Irtysh river system (from the mouth of the Iset River to the confluence with the Ob River)

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, Alexander I. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation)]. E-mail: nikitin@typhoon.obninsk.ru; Chumichev, Vladimir B. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Valetova, Nailia K. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Katrich, Ivan Yu. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Kabanov, Alexander I. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Dunaev, Gennady E. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Shkuro, Valentina N. [SI RPA ' Typhoon' of the Roshydromet, 82, Lenin avenue, Obninsk, Kaluga region 249038 (Russian Federation); Rodin, Victor M. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation); Mironenko, Alexander N. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation); Kireeva, Elena V. [Tobolsk Biological Station of RAS, 15, Voikov street, Tobolsk, Tyumen region 626150 (Russian Federation)

    2007-07-15

    Data on content of {sup 90}Sr, {sup 137}Cs, {sup 239,240}Pu and {sup 3}H in water of the Tobol-Irtysh part of the Techa-Iset-Tobol-Irtysh-Ob river system (through which the 'Mayak' PA radioactive wastes are transported) are presented and discussed. The data were received in 2004-2005 under the ISTC project on radioecological monitoring of the Tobol and Irtysh rivers. Monthly observations of {sup 137}Cs, {sup 90}Sr and {sup 3}H content in water in the area of the Tobol and Irtysh confluence have been conducted starting from May 2004. To obtain information on the investigated river system as a whole, the radioecological survey of the Tobol and Irtysh rivers at the section from the mouth of the Iset River to the confluence with the Ob River was carried out in 2004. It is shown that the impact of 'Mayak' PA waste transport by {sup 90}Sr is distinctly traced as far as the area of the Irtysh and Ob confluence.

  8. The current content of artificial radionuclides in the water of the Tobol-Irtysh river system (from the mouth of the Iset River to the confluence with the Ob River)

    International Nuclear Information System (INIS)

    Nikitin, Alexander I.; Chumichev, Vladimir B.; Valetova, Nailia K.; Katrich, Ivan Yu.; Kabanov, Alexander I.; Dunaev, Gennady E.; Shkuro, Valentina N.; Rodin, Victor M.; Mironenko, Alexander N.; Kireeva, Elena V.

    2007-01-01

    Data on content of 90 Sr, 137 Cs, 239,240 Pu and 3 H in water of the Tobol-Irtysh part of the Techa-Iset-Tobol-Irtysh-Ob river system (through which the 'Mayak' PA radioactive wastes are transported) are presented and discussed. The data were received in 2004-2005 under the ISTC project on radioecological monitoring of the Tobol and Irtysh rivers. Monthly observations of 137 Cs, 90 Sr and 3 H content in water in the area of the Tobol and Irtysh confluence have been conducted starting from May 2004. To obtain information on the investigated river system as a whole, the radioecological survey of the Tobol and Irtysh rivers at the section from the mouth of the Iset River to the confluence with the Ob River was carried out in 2004. It is shown that the impact of 'Mayak' PA waste transport by 90 Sr is distinctly traced as far as the area of the Irtysh and Ob confluence

  9. Comparative Analysis of Upper Ocean Heat Content Variability from Ensemble Operational Ocean Analyses

    Science.gov (United States)

    Xue, Yan; Balmaseda, Magdalena A.; Boyer, Tim; Ferry, Nicolas; Good, Simon; Ishikawa, Ichiro; Rienecker, Michele; Rosati, Tony; Yin, Yonghong; Kumar, Arun

    2012-01-01

    Upper ocean heat content (HC) is one of the key indicators of climate variability on many time-scales extending from seasonal to interannual to long-term climate trends. For example, HC in the tropical Pacific provides information on thermocline anomalies that is critical for the longlead forecast skill of ENSO. Since HC variability is also associated with SST variability, a better understanding and monitoring of HC variability can help us understand and forecast SST variability associated with ENSO and other modes such as Indian Ocean Dipole (IOD), Pacific Decadal Oscillation (PDO), Tropical Atlantic Variability (TAV) and Atlantic Multidecadal Oscillation (AMO). An accurate ocean initialization of HC anomalies in coupled climate models could also contribute to skill in decadal climate prediction. Errors, and/or uncertainties, in the estimation of HC variability can be affected by many factors including uncertainties in surface forcings, ocean model biases, and deficiencies in data assimilation schemes. Changes in observing systems can also leave an imprint on the estimated variability. The availability of multiple operational ocean analyses (ORA) that are routinely produced by operational and research centers around the world provides an opportunity to assess uncertainties in HC analyses, to help identify gaps in observing systems as they impact the quality of ORAs and therefore climate model forecasts. A comparison of ORAs also gives an opportunity to identify deficiencies in data assimilation schemes, and can be used as a basis for development of real-time multi-model ensemble HC monitoring products. The OceanObs09 Conference called for an intercomparison of ORAs and use of ORAs for global ocean monitoring. As a follow up, we intercompared HC variations from ten ORAs -- two objective analyses based on in-situ data only and eight model analyses based on ocean data assimilation systems. The mean, annual cycle, interannual variability and longterm trend of HC have

  10. Plant species of Okhla Bird Sanctuary: a wetland of Upper Gangetic Plains, India [with erratum

    OpenAIRE

    Manral, Upma; Raha, Angshuman; Solanki, Ridhima; Hussain, Syed; Babu, Mattozbiyil; Mohan, Dhananjai; Veeraswami, Gopi; Sivakumar, K.; Talukdar, Gautam

    2013-01-01

    The Okhla Bird Sanctuary (OBS), a man-modified floodplain wetland having high human impact, is located in an urbanized landscape. Its location in the Central Asian Flyway of migratory birds makes it an ideal transit and wintering ground for birds. This paper describes the vegetation composition and significance of the Sanctuary as a bird habitat. A floristic survey was carried out from winter 2009 to spring 2010 while preparing a management plan for OBS. 192 species of plants belonging to 46 ...

  11. Emergency readmission following acute upper gastrointestinal bleeding

    DEFF Research Database (Denmark)

    Strömdahl, Martin; Helgeson, Johan; Kalaitzakis, Evangelos

    2017-01-01

    OBJECTIVE: To assess the occurrence, clinical predictors, and associated mortality of all-cause emergency readmissions after acute upper gastrointestinal bleeding (AUGIB). PATIENTS AND METHODS: All patients with AUGIB from an area of 600 000 inhabitants in Sweden admitted in a single institution...

  12. [Upper lateral incisor with 2 canals].

    Science.gov (United States)

    Fabra Campos, H

    1991-01-01

    Clinical case summary of the patient with an upper lateral incisor with two root canals. The suspicion that there might be an anatomic anomaly in the root that includes a complex root canal system was made when an advanced radicular groove was detected in the lingual surface or an excessively enlarged cingulum.

  13. Upper Limit for Regional Sea Level Projections

    Science.gov (United States)

    Jevrejeva, Svetlana; Jackson, Luke; Riva, Riccardo; Grinsted, Aslak; Moore, John

    2016-04-01

    With more than 150 million people living within 1 m of high tide future sea level rise is one of the most damaging aspects of warming climate. The latest Intergovernmental Panel on Climate Change report (AR5 IPCC) noted that a 0.5 m rise in mean sea level will result in a dramatic increase the frequency of high water extremes - by an order of magnitude, or more in some regions. Thus the flood threat to the rapidly growing urban populations and associated infrastructure in coastal areas are major concerns for society. Hence, impact assessment, risk management, adaptation strategy and long-term decision making in coastal areas depend on projections of mean sea level and crucially its low probability, high impact, upper range. With probabilistic approach we produce regional sea level projections taking into account large uncertainties associated with Greenland and Antarctica ice sheets contribution. We calculate the upper limit (as 95%) for regional sea level projections by 2100 with RCP8.5 scenario, suggesting that for the most coastlines upper limit will exceed the global upper limit of 1.8 m.

  14. Diagnosis and treatment of upper limb apraxia.

    Science.gov (United States)

    Dovern, A; Fink, G R; Weiss, P H

    2012-07-01

    Upper limb apraxia, a disorder of higher motor cognition, is a common consequence of left-hemispheric stroke. Contrary to common assumption, apraxic deficits not only manifest themselves during clinical testing but also have delirious effects on the patients' everyday life and rehabilitation. Thus, a reliable diagnosis and efficient treatment of upper limb apraxia is important to improve the patients' prognosis after stroke. Nevertheless, to date, upper limb apraxia is still an underdiagnosed and ill-treated entity. Based on a systematic literature search, this review summarizes the current tools of diagnosis and treatment strategies for upper limb apraxia. It furthermore provides clinicians with graded recommendations. In particular, a short screening test for apraxia, and a more comprehensive diagnostic apraxia test for clinical use are recommended. Although currently only a few randomized controlled studies investigate the efficacy of different apraxia treatments, the gesture training suggested by Smania and colleagues can be recommended for the therapy of apraxia, the effects of which were shown to extend to activities of daily living and to persist for at least 2 months after completion of the training. This review aims at directing the reader's attention to the ecological relevance of apraxia. Moreover, it provides clinicians with appropriate tools for the reliable diagnosis and effective treatment of apraxia. Nevertheless, this review also highlights the need for further research into how to improve diagnosis of apraxia based on neuropsychological models and to develop new therapeutic strategies.

  15. Team Teaching at Upper Arlington School.

    Science.gov (United States)

    Jackson, Annette R.

    1968-01-01

    Team teaching has been used for 4 years in the 10th-grade English classes at Upper Arlington High School near Columbus, Ohio. Units are prepared, presented, and evaluated by teachers working together voluntarily. A 6-day American literature unit introducing Romanticism has been particularly successful. The contrasts between Neoclassicism and…

  16. Upper Atmosphere Research Report Number 2

    Science.gov (United States)

    1946-12-30

    as a whol,. The history of the program was given in some detail in the first report*. The part of the Naval Research Laboratory in upper atmosphere...5B and 6. The third gage was installed as a service to the spectroscopy program. The gago elements were simply 6 watt, 110 volt Mazda pilot *1 lamps

  17. Upper gastrointestinal endoscopic findings and prevalence of ...

    African Journals Online (AJOL)

    Upper gastrointestinal endoscopic findings and prevalence of Helicobacter pylori infection among adult patients with dyspepsia in northern Tanzania. ... Endoscopy (EGD) for initial work up. Study on antimicrobial susceptibility pattern of H. pylori is recommended to guide choices for evidence based treatment option.

  18. Helicobacter pylori and upper digestive diseases - diagnosis ...

    African Journals Online (AJOL)

    Results: The prevalence of Helicobacter pylori in patients with various upper gastrointestinal problems was 84.7%. The use of medication that can reduce the H. pylori density was common among the infected patients, as history of antibiotics use, acid suppressant use and medications for eradication treatment were ...

  19. Local anaesthesia in the upper jaw

    NARCIS (Netherlands)

    Baart, J.A.; Baart, J.A.; Brand, H.S.

    2017-01-01

    The sensory innervation of the upper jaw arises from the second trunk of the trigeminal nerve, the maxillary nerve. This main branch of the trigeminal nerve leaves the neurocranium via the foramen rotundum, reaches the pterygopalatine fossa and runs straight through the infraorbital nerve, branching

  20. X-Ray Exam: Femur (Upper Leg)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español X-Ray Exam: Femur (Upper Leg) KidsHealth / For Parents / X- ... Muscles, and Joints Broken Bones Getting an X-ray (Video) X-Ray (Video) View more Partner Message About Us ...

  1. The Upper Permian in the Netherlands

    NARCIS (Netherlands)

    Visser, W.A.

    1955-01-01

    The Upper Permian in the Netherlands, as known from borehole data, is deposited in a mainly evaporitic facies north of the Brabant and Rhenish Massifs. In the extreme south (Belgian Campine, de Peel) a near-shore facies of reef dolomites and elastics occurs. In the western and central Netherlands

  2. Upper blepharoplasty : Defying dogmas and clarifying uncertainties

    NARCIS (Netherlands)

    Pool, Shariselle Mirna Wietske

    2016-01-01

    Upper blepharoplasty is one of the most commonly performed procedures by (oculo)plastic surgeons and it is generally recognized as a relatively easy technical procedure. However, seemingly minor aspects before, during and after surgery can be identified that significantly contribute to surgical

  3. Starting manufacturing phase of ITER upper ports

    Energy Technology Data Exchange (ETDEWEB)

    Utin, Yuri, E-mail: yuri.utin@iter.org [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Alekseev, Alexander; Sborchia, Carlo; Choi, Changho; Albin, Vincent; Barabash, Vladimir; Davis, James [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Fabritsiev, Sergey [NTC Sintez, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Giraud, Benoit; Guirao, Julio [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Koenig, Werner [MAN Diesel & Turbo SE, Werftstrasse 17, Deggendorf (Germany); Kedrov, Igor; Kuzmin, Evgeny [NTC Sintez, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Levesy, Bruno; Martinez, Jean-Marc [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Prebeck, Markus [MAN Diesel & Turbo SE, Werftstrasse 17, Deggendorf (Germany); Privalova, Elena [NTC Sintez, Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Ranzinger, Franz [MAN Diesel & Turbo SE, Werftstrasse 17, Deggendorf (Germany); Savrukhin, Petr [Russian Federation ITER Domestic Agency, Kurchatov sq.1, 123182 Moscow (Russian Federation); Schiller, Thomas [MAN Diesel & Turbo SE, Werftstrasse 17, Deggendorf (Germany); and others

    2015-10-15

    Highlights: • The port plugs are attached to the ports with high-strength fasteners. • Tightening of the fasteners via inductive heating was tested. • A concept for the port/plug sealing with metal-type gaskets has progressed. • Manufacturing design of the Upper Ports is in progress. • A full-scale mock-up of double-wall part of the port stub extension is in manufacturing process – acceptable final tolerances are expected. - Abstract: The ITER Vacuum Vessel (VV) features upper, equatorial and lower ports. The upper and regular equatorial ports are occupied by the port plugs. Although the port design has been overall completed in the past, the design of some remaining interfaces was still in progress: in particular, the Sealing Flange package, which includes the high-vacuum seals and the plug fasteners. As the ITER construction phase has started, the procurement of the VV ports has been launched. The VV upper ports will be procured by the Russian Federation Domestic Agency. The main suppliers were selected and the manufacturing design of the first parts is in full progress now. Since the VV is classified at nuclear level N2, the design and manufacture of its components are to be compliant with the French RCC-MR code and regulations for nuclear pressure equipment in France. These regulations make a strong impact to the port design and manufacturing process.

  4. Starting manufacturing phase of ITER upper ports

    International Nuclear Information System (INIS)

    Utin, Yuri; Alekseev, Alexander; Sborchia, Carlo; Choi, Changho; Albin, Vincent; Barabash, Vladimir; Davis, James; Fabritsiev, Sergey; Giraud, Benoit; Guirao, Julio; Koenig, Werner; Kedrov, Igor; Kuzmin, Evgeny; Levesy, Bruno; Martinez, Jean-Marc; Prebeck, Markus; Privalova, Elena; Ranzinger, Franz; Savrukhin, Petr; Schiller, Thomas

    2015-01-01

    Highlights: • The port plugs are attached to the ports with high-strength fasteners. • Tightening of the fasteners via inductive heating was tested. • A concept for the port/plug sealing with metal-type gaskets has progressed. • Manufacturing design of the Upper Ports is in progress. • A full-scale mock-up of double-wall part of the port stub extension is in manufacturing process – acceptable final tolerances are expected. - Abstract: The ITER Vacuum Vessel (VV) features upper, equatorial and lower ports. The upper and regular equatorial ports are occupied by the port plugs. Although the port design has been overall completed in the past, the design of some remaining interfaces was still in progress: in particular, the Sealing Flange package, which includes the high-vacuum seals and the plug fasteners. As the ITER construction phase has started, the procurement of the VV ports has been launched. The VV upper ports will be procured by the Russian Federation Domestic Agency. The main suppliers were selected and the manufacturing design of the first parts is in full progress now. Since the VV is classified at nuclear level N2, the design and manufacture of its components are to be compliant with the French RCC-MR code and regulations for nuclear pressure equipment in France. These regulations make a strong impact to the port design and manufacturing process.

  5. Uprated OMS engine for upper stage propulsion

    Science.gov (United States)

    Boyd, William C.

    1986-01-01

    The results of a pre-development component demonstration program on the use of a gas generator-driven turbopump that increases the Space Shuttle's Orbital Maneuvering Engine (OME) operating pressure are given. Tests and analysis confirm the the capability of the concept to meet or exceed performance and life requirements. Storable propellant upper stage concepts are also discussed.

  6. Do statins protect against upper gastrointestinal bleeding?

    DEFF Research Database (Denmark)

    Gulmez, Sinem Ezgi; Lassen, Annmarie Touborg; Aalykke, Claus

    2009-01-01

    AIMS: Recently, an apparent protective effect of statins against upper gastrointestinal bleeding (UGB) was postulated in a post hoc analysis of a randomized trial. We aimed to evaluate the effect of statin use on acute nonvariceal UGB alone or in combinations with low-dose aspirin and other...

  7. Teaching Astrophysics to Upper Level Undergraduates

    Science.gov (United States)

    Van Dorn Bradt, Hale

    2010-03-01

    A Socratic peer-instruction method for teaching upper level undergraduates is presented. Basically, the instructor sits with the students and guides their presentations of the material. My two textbooks* (on display) as well as many others are amenable to this type of teaching. *Astronomy Methods - A Physical Approach to Astronomical Observations (CUP 2004) *Astrophysics Processes-The Physics of Astronomical Phenomena (CUP 2008)

  8. Global Change in the Upper Atmosphere

    Czech Academy of Sciences Publication Activity Database

    Laštovička, Jan; Akmaev, R. A.; Beig, G.; Bremer, J.; Emmert, J. T.

    2006-01-01

    Roč. 314, č. 5803 (2006), s. 1253-1254 ISSN 0036-8075 R&D Projects: GA MŠk OC 091 Institutional research plan: CEZ:AV0Z30420517 Keywords : Global change * Upper Atmosphere * Ionosphere Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 30.028, year: 2006

  9. Up-to-date concentrations of long-lived artificial radionuclides in the Tom and Ob rivers in the area influenced by discharges from Siberian chemical combine

    International Nuclear Information System (INIS)

    Nikitin, A.I.; Kryshev, I.I.; Bashkirov, N.I.; Valetova, N.K.; Dunaev, G.E.; Kabanov, A.I.; Katrich, I.Yu; Krutovsky, A.O.; Nikitin, V.A.; Petrenko, G.I.; Polukhina, A.M.; Selivanova, G.V.; Shkuro, V.N.

    2012-01-01

    The Siberian Chemical Combine (SCC) is located in Seversk (formerly known as Tomsk-7) in the Tomsk Region of the Russian Federation. The main contribution of radionuclides in the SCC process water discharged into the Tom River was from the single-pass reactors, now removed from service (the last SCC reactor was shutdown on June 5, 2008). The data on the concentrations of 90 Sr, 137 Cs, 239,240 Pu and other artificial radionuclides in water, bottom sediments and flood-plain soils of the Tom and Ob rivers from Tomsk to the confluence of the rivers, are presented and discussed. The results of measurements carried out after shutdown of the last SCC single-pass reactor indicated no radiologically significant consequences of SCC activities for the studied water environment compartments. Contemporary activity concentrations of long-lived artificial radionuclides 3 H, 90 Sr, 137 Cs and 239,240 Pu in river water were below the intervention levels established by current regulations of the Russian Federation for these radionuclides. The results of 3 H analysis in water from the Tom and Samuska rivers demonstrated no inflow of contaminated formation water to surface water from the sites where liquid radioactive wastes of the SCC were injected below the surface. However, the density of flood-plain soil contamination by long-lived 137 Cs in the area influenced by SCC liquid discharges was higher than regional technogenic background. There were local flood-plain areas contaminated not only by 137 Cs, but also other gamma-emitters, such as 60 Co and 152 Eu.

  10. Characterization of a thermostable recombinant l-rhamnose isomerase from Caldicellulosiruptor obsidiansis OB47 and its application for the production of l-fructose and l-rhamnulose.

    Science.gov (United States)

    Chen, Ziwei; Xu, Wei; Zhang, Wenli; Zhang, Tao; Jiang, Bo; Mu, Wanmeng

    2018-04-01

    l-Hexoses are rare sugars that are important components and precursors in the synthesis of biological compounds and pharmaceutical drugs. l-Rhamnose isomerase (L-RI, EC 5.3.1.14) is an aldose-ketose isomerase that plays a significant role in the production of l-sugars. In this study, a thermostable, l-sugar-producing L-RI from the hyperthermophile Caldicellulosiruptor obsidiansis OB47 was characterized. The recombinant L-RI displayed maximal activity at pH 8.0 and 85 °C and was significantly activated by Co 2+ . It exhibited a relatively high thermostability, with measured half-lives of 24.75, 11.55, 4.15 and 3.30 h in the presence of Co 2+ at 70, 75, 80 and 85 °C, respectively. Specific activities of 277.6, 57.9, 13.7 and 9.6 U mg -1 were measured when l-rhamnose, l-mannose, d-allose and l-fructose were used as substrates, respectively. l-Rhamnulose was produced with conversion ratios of 44.0% and 38.6% from 25 and 50 g L -1 l-rhamnose, respectively. l-Fructose was also efficiently produced by the L-RI, with conversion ratios of 67.0% and 58.4% from 25 and 50 g L -1 l-mannose, respectively. The recombinant L-RI could effectively catalyze the formation of l-rhamnulose and l-fructose, suggesting that it was a promising candidate for industrial production of l-rhamnulose and l-fructose. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  11. Computer vision for shoe upper profile measurement via upper and sole conformal matching

    Science.gov (United States)

    Hu, Zhongxu; Bicker, Robert; Taylor, Paul; Marshall, Chris

    2007-01-01

    This paper describes a structured light computer vision system applied to the measurement of the 3D profile of shoe uppers. The trajectory obtained is used to guide an industrial robot for automatic edge roughing around the contour of the shoe upper so that the bonding strength can be improved. Due to the specific contour and unevenness of the shoe upper, even if the 3D profile is obtained using computer vision, it is still difficult to reliably define the roughing path around the shape. However, the shape of the corresponding shoe sole is better defined, and it is much easier to measure the edge using computer vision. Therefore, a feasible strategy is to measure both the upper and sole profiles, and then align and fit the sole contour to the upper, in order to obtain the best fit. The trajectory of the edge of the desired roughing path is calculated and is then smoothed and interpolated using NURBS curves to guide an industrial robot for shoe upper surface removal; experiments show robust and consistent results. An outline description of the structured light vision system is given here, along with the calibration techniques used.

  12. CT arteriography of the upper abdomen

    Energy Technology Data Exchange (ETDEWEB)

    Hasuo, K; Matsuura, K; Baba, H; Numaguchi, Y; Komaki, S [Kyushu Univ., Fukuoka (Japan). Faculty of Medicine

    1980-04-01

    The technique of CT arteriography was introduced, and CT images of the upper abdomen were explained. Very clear enhancement of parenchyma and vessels (especially portal vein) of the object organs could be obtained by CT arteriography of the upper abdomen, anatomical structures of organs were identified more easily by CT arteriography than by conventional CT, and the amount of information obtained was increased by using CT arteriography. However, the indication of CT arteriography must be limited, because of its complexity that CT arteriography is performed after angiography and involves the invasion of patients' bodies. As described in many reports, CT arteriography is useful for malignant tumors of the liver, and it is worthwhile, especially when surgery for hepatocellular carcinoma is considered. CT arteriography for organs except the liver has not been discussed sufficiently. Therefore, an application of this method for other organs must be decided after consideration of the balance of the amount of information obtained by CT arteriography with invasion to patients.

  13. Temperature Profile of the Upper Mantle

    International Nuclear Information System (INIS)

    Anderson, O.L.

    1980-01-01

    Following the procedure outlined by Magnitsky [1971], thermal profiles of the upper mantle are computed by deriving the thermal gradient from the seismic data given as dv/sub s//drho used along with the values of (dv/sub s//dT9/sub p/ and (dv/sub s//dP)/sub T/ of selected minerals, measured at high temperature. The resulting values of dT/dZ are integrated from 380 km upward toward the surface, where the integrating constant is taken from Akagi and Akimoto's work, T=1400 0 C at 380 km. The resulting geotherms for minerals are used to derive geotherms for an eclogite mantle and a lherzolite mantle, with and without partial melting in the low-velocity zone. The geotherms are all subadiabatic, and some are virtually isothermal in the upper mantle. Some are characterized by a large thermal hump at the lithosphere boundary

  14. Emulating Upper Limb Disorder for Therapy Education

    Directory of Open Access Journals (Sweden)

    Noor Ayuni binti Che Zakaria

    2014-11-01

    Full Text Available Robotics not only contributes to the invention of rehabilitation devices, it can also enhance the quality of medical education. In recent years, the use of patient simulators and part-task trainers in the medical education field has brought meaningful improvements in the training of medical practitioners. Nevertheless, in the context of therapy training for upper limb disorders, trainee therapists still have to engage directly with the patients to gain experience of the rehabilitation of physical diseases. In this work, a high-fidelity part-task trainer that is able to reproduce the stiffness of spasticity and rigidity symptoms of the upper limb, such as those observed in post-stroke patients and Parkinson's disease patients, has been developed. Based on the evaluation carried out by two experienced therapists, the developed part-task trainer is able to simulate different patient cases and help trainee therapists gain pre-clinical experience in a safe and intuitive learning environment.

  15. Upper gastrointestinal bleeding in irbid, jordan

    International Nuclear Information System (INIS)

    Banisalamah, A.A.; Mraiat, Z.M.

    2007-01-01

    To define the various causes of nonvariceal upper gastrointestinal bleeding, to outline management modalities and to determine the final outcome of patients. A retrospective analysis of patients presenting with upper gastrointestinal (UGI) bleeding from January 2003 to December 2006 (4 years) was conducted. Patients with endoscopically proven variceal bleeding were excluded. Out of the 120 patients, most of the patients belonged to an age group of more than 50 years (mean 48.5 years). Haematemesis was the most common presentation and Acute Gastric Mucosal Lesion (AGML) was the most frequently encountered lesion. The cause of bleeding was not identified in 10 patients (undetermined group). Twenty-two (18.3%) underwent surgery and we had an overall mortality of 15.8%. AGML being the leading cause can be managed conservatively most of the time. There is a male preponderance and the incidence and mortality increases with advancing age. The undetermined group remains a diagnostic problem. (author)

  16. Stereotactic radiosurgery with an upper partial denture

    International Nuclear Information System (INIS)

    Tayama, Shusaku; Kunieda, Etsuo; Takeda, Atsushi; Takeda, Toshiaki; Oku, Yohei

    2009-01-01

    A 54-year-old male with partial denture underwent stereotactic radiosurgery with an infrared camera-guided system for a metastatic brain tumor arising from lung cancer. Although this method utilizes a biteplate mounted on the upper jaw to detect head movement, the patient only had four teeth in his upper jaw. In order to stabilize the biteplate, the maxillary denture was fixed to the biteplate with an autopolymerizing resin. In addition, the rest-occlusal position of the lower jaw was impressed on the inferior surface of the biteplate with an autopolymerizing resin. To assess reproducibility and stability, the distance between the left and right incus and left and right markers was measured during pre-planning, as well as before and after stereotactic irradiation. Wearing the biteplate ensures the accuracy of radiotherapy planning for the implementation of radiosurgery in patients who have many maxillary teeth missing. However, a large degree of error was observed when the biteplate was removed. (author)

  17. Upper functional gastrointestinal disorders in young adults.

    Science.gov (United States)

    Adibi, Peyman; Behzad, Ebrahim; Shafieeyan, Mohammad; Toghiani, Ali

    2012-01-01

    Functional Gastrointestinal disorders (FGID) are common disorders in gastroenterology which are common in young adults. The aim of this study is evaluating the prevalence of upper FGID in iranian young adults. This was a cross-sectional study which was on 995 persons who were going to marry. A ROME III based questionnaire was used to determine the frequency of upper GI Syndromes among the sample population. Our results determined 74 subjects had functional dyspepsia (36 subjects diagnosed as postprandial distress syndrome patient and Epigastric pain syndrome was seen in 38 subjects). Functional heartburn was diagnosed in 52 participants. Globus was seen in 35 subjects and 41 had unspecified excessive belching. Many epidemiologic studies were done all around the world but there are different reports about prevalence and incidence of FGIDs. Our results were agreed with reported prevalence of FGIDs in Iran in adults. And our findings were agreed with some other Asian studies.

  18. Upper Extremity Deep Vein Thromboses: The Bowler and the Barista

    Directory of Open Access Journals (Sweden)

    Seth Stake

    2016-01-01

    Full Text Available Effort thrombosis of the upper extremity refers to a deep venous thrombosis of the upper extremity resulting from repetitive activity of the upper limb. Most cases of effort thrombosis occur in young elite athletes with strenuous upper extremity activity. This article reports two cases who both developed upper extremity deep vein thromboses, the first being a 67-year-old bowler and the second a 25-year-old barista, and illustrates that effort thrombosis should be included in the differential diagnosis in any patient with symptoms concerning DVT associated with repetitive activity. A literature review explores the recommended therapies for upper extremity deep vein thromboses.

  19. Upper Extremity Deep Vein Thromboses: The Bowler and the Barista.

    Science.gov (United States)

    Stake, Seth; du Breuil, Anne L; Close, Jeremy

    2016-01-01

    Effort thrombosis of the upper extremity refers to a deep venous thrombosis of the upper extremity resulting from repetitive activity of the upper limb. Most cases of effort thrombosis occur in young elite athletes with strenuous upper extremity activity. This article reports two cases who both developed upper extremity deep vein thromboses, the first being a 67-year-old bowler and the second a 25-year-old barista, and illustrates that effort thrombosis should be included in the differential diagnosis in any patient with symptoms concerning DVT associated with repetitive activity. A literature review explores the recommended therapies for upper extremity deep vein thromboses.

  20. Understanding Nuclei in the upper sd - shell

    OpenAIRE

    Sarkar, M. Saha; Bisoi, Abhijit; Ray, Sudatta; Kshetri, Ritesh; Sarkar, S.

    2013-01-01

    Nuclei in the upper-$sd$ shell usually exhibit characteristics of spherical single particle excitations. In the recent years, employment of sophisticated techniques of gamma spectroscopy has led to observation of high spin states of several nuclei near A$\\simeq$ 40. In a few of them multiparticle, multihole rotational states coexist with states of single particle nature. We have studied a few nuclei in this mass region experimentally, using various campaigns of the Indian National Gamma Array...

  1. Upper limb position control in fibromyalgia

    Directory of Open Access Journals (Sweden)

    Bardal Ellen

    2012-09-01

    Full Text Available Abstract Background Motor problems are reported by patients with fibromyalgia (FM. However, the mechanisms leading to alterations in motor performance are not well understood. In this study, upper limb position control during sustained isometric contractions was investigated in patients with FM and in healthy controls (HCs. Methods Fifteen female FM patients and 13 HCs were asked to keep a constant upper limb position during sustained elbow flexion and shoulder abduction, respectively. Subjects received real-time visual feedback on limb position and both tasks were performed unloaded and while supporting loads (1, 2, and 3 kg. Accelerations of the dominant upper limb were recorded, with variance (SD of mean position and power spectrum analysis used to characterize limb position control. Normalized power of the acceleration signal was extracted for three frequency bands: 1–3 Hz, 4–7 Hz, and 8–12 Hz. Results Variance increased with load in both tasks (P 0.001 but did not differ significantly between patients and HCs (P > 0.17. Power spectrum analysis showed that the FM patients had a higher proportion of normalized power in the 1–3 Hz band, and a lower proportion of normalized power in the 8–12 Hz band compared to HCs (P 0.05. The results were consistent for all load conditions and for both elbow flexion and shoulder abduction. Conclusion FM patients exhibit an altered neuromuscular strategy for upper limb position control compared to HCs. The predominance of low-frequency limb oscillations among FM patients may indicate a sensory deficit.

  2. Bilateral tumors of the upper urothelium

    Directory of Open Access Journals (Sweden)

    Đokić Milan

    2006-01-01

    Full Text Available Introduction: The incidence of tumors of the upper urothelium is high in our country, apart from their relation to specific regions (BEN and PBEN and their frequent bilateralism. Bilateral forms are present in significant percentage and are followed, in most cases, by renal failure, which speaks in favor of conservative surgery, if possible. Objective: The aim of the study was to present epidemiological, pathoanatomical and clinical characteristics of bilateral tumors of the upper urothelium and evaluate the Results of their treatment. Method: Our retrospective study analyzed 12 patients with bilateral tumors of the upper urothelium who were treated in the period from 1992 to 1996, according to their epidemiological, clinical, pathoanatomical and pathohistological characteristics, type of surgical treatment and relevant success. Results: In the observed period, bilateral tumors of the upper urothelium were found in 8.2% of our patients. In the group of 12 patients, 5 females and 7 males, 11 cases were from the region of Balkan Endemic Nephropathy (BEN. Renal failure was recorded in high percentage (66%. Radical surgical treatment - total nephroureterectomy was performed in 9 kidney units, and conservative operation in 15 units. Relapse significantly depended on tumor stage and grade, not on type of surgical treatment in the majority of cases. Five-year survival was 58.33%; major cause of death was associated with further evolution of tumor, recurrence and tumor dissemination, respectively, while renal failure complications were the cause of death in one case. Conclusion: The success of treatment mainly depends on tumor stage and grade and not on type of surgical Method in conservative treatment, but renal failure and its complications are an important risk factor in these patients.

  3. Rare upper gastrointestinal hemorrhage of cetuximab

    OpenAIRE

    Duan, Shi-Jie; Gao, Zi-Ming; Wang, Peng-Liang; Gong, Bao-Cheng; Huang, Han-Wei; Luo, Lei; Wang, Xin; Xing, Ya-Nan; Xu, Hui-Mian; Liu, Fu-Nan

    2017-01-01

    Abstract Rationale: cetuximab, an epidermal growth factor receptor inhibitor, is a targeted therapeutic regimen of colorectal cancers. Several common adverse effects have been found, such as cutaneous or gastrointestinal toxicity. However, according to the articles had been published, upper gastrointestinal bleeding (UGIB) is considered to be rare and its mechanism remains unclear. Patient concerns: In this report, we presented a 42-year-old male patient with advanced recto-sigmoid cancer. Af...

  4. PWR upper/lower internals shield

    Energy Technology Data Exchange (ETDEWEB)

    Homyk, W.A. [Indian Point Station, Buchanan, NY (United States)

    1995-03-01

    During refueling of a nuclear power plant, the reactor upper internals must be removed from the reactor vessel to permit transfer of the fuel. The upper internals are stored in the flooded reactor cavity. Refueling personnel working in containment at a number of nuclear stations typically receive radiation exposure from a portion of the highly contaminated upper intervals package which extends above the normal water level of the refueling pool. This same issue exists with reactor lower internals withdrawn for inservice inspection activities. One solution to this problem is to provide adequate shielding of the unimmersed portion. The use of lead sheets or blankets for shielding of the protruding components would be time consuming and require more effort for installation since the shielding mass would need to be transported to a support structure over the refueling pool. A preferable approach is to use the existing shielding mass of the refueling pool water. A method of shielding was devised which would use a vacuum pump to draw refueling pool water into an inverted canister suspended over the upper internals to provide shielding from the normally exposed components. During the Spring 1993 refueling of Indian Point 2 (IP2), a prototype shield device was demonstrated. This shield consists of a cylindrical tank open at the bottom that is suspended over the refueling pool with I-beams. The lower lip of the tank is two feet below normal pool level. After installation, the air width of the natural shielding provided by the existing pool water. This paper describes the design, development, testing and demonstration of the prototype device.

  5. New discoveries in Upper and Middle Magdalena

    International Nuclear Information System (INIS)

    Carta Petrolera

    1998-01-01

    In six association contracts and one risk participation contract may give Colombia the possibility of finding new oil reserves. These prospects, located in the Upper and Middle Magdalena Valleys and the Eastern Plains. the completion process, evaluation, confirmation and commercialization should be in the next two years, these new discoveries also reveal interesting geological aspects; some in fractured limestone, similar to the found at Maracaibo lake in Venezuela, where vast oil fields were discovered

  6. [Antithrombotic therapy and nonvariceal upper gastrointestinal bleeding].

    Science.gov (United States)

    Belanová, Veronika; Gřiva, Martin

    2015-12-01

    The incidence of acute upper gastrointestinal bleeding is about 85-108/100,000 inhabitants per year, nonvariceal bleeding accounts for 80-90%. Antiplatelet and anticoagulation treatment are the significant risk factors for upper gastrointestinal bleeding. To evaluate the occurrence of upper gastrointestinal bleeding in the general community of patients in a county hospital. And to compare the role played by antiplatelet and anticoagulation drugs and other risk medication. Retrospective analysis of patients over 18 years of age who underwent endoscopy for acute upper gastrointestinal bleeding or anaemia (haemoglobinupper gastrointestinal tract during a hospital stay in 2013 (from January to June). We included 111 patients of average age 69±15 years, men 60%. Nonvariceal bleeding accounted for 90% of the cases. None of the patients with variceal bleeding (10% of patients) took antiplatelet or anticoagulation therapy. There were 100 patients with nonvariceal bleeding of average age 70±15, 61% men. With the symptoms of acute bleeding (hematemesis, melena) presented in 73% of patients. The most frequent cause of bleeding was gastric and duodenal ulcer (54%). 32% of patients with nonvariceal bleeding had antiplatelets, 19% anticoagulants and 10% used nonsteroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors or corticosteroids. 30-days mortality of patients with nonvariceal bleeding was 11%, annual mortality was 23%. There was no significant difference in mortality, blood transfusion requirements or surgical intervention between the patients with antithrombotic agents and without them. 25% of patients (8 patients) using acetylsalicylic acid did not fulfil the indication for this treatment. Among the patients examined by endoscopy for symptomatic nonvariceal bleeding and/or anaemia (haemoglobingastrointestinal bleeding. With regard to that, it is alarming, that there still exists a nonnegligible percentage of patients taking acetylsalicylic acid even

  7. Regional aerosol deposition in human upper airways

    International Nuclear Information System (INIS)

    Swift, D.L.

    1989-01-01

    During the report period significant progress on the quantitative understanding of regional upper airway deposition of airborne particle has been realized. Replicate models of the human upper airways obtained from post-mortem casting of the nasal, oral, pharyngeal, laryngeal and upper tracheal regions and in vivo magnetic resonance imaging (MRI) of the same regions of adults and children have been employed to determine the overall and local deposition characteristics of aerosols in the ultrafine (1--100 μm diameter) and fine (0.8--12 μm diameter) region. Studies have been carried out for both nasal and oral breathing during inspiratory and expiratory flow at constant flow rates representative of rest and states of exercise. The results of these investigations indicate that particles in the size range of ''unattached'' radon progeny (1--3 nm) are deposited in both the nasal and oral passages with high efficiency (60--80%) for both inspiration and expiration, with the nasal deposition being somewhat greater (5--10%) than oral deposition. The effect of flow rate on upper airway deposition for both pathways is not great; data analysis indicates that the deposition for all flow rates from 4--50 liters/minute can be grouped by plotting deposition vs Q- 1/8 , where Q is flow rate, a far weaker dependency than observed for inertial deposition. Diffusional transport is the primary mechanism of deposition, and size dependence can be accounted for by plotting, deposition percent vs D n where D is particle diffusion coefficient and n ranges from 0.5--0.66. 2 refs

  8. Upper shielding body in LMFBR type reactors

    International Nuclear Information System (INIS)

    Shoji, Koichi.

    1986-01-01

    Purpose: Preference is given to the strength and thermal insulation of a roof slab thereby ensuring axial size and improving the operationability upon inserting the control rod in the upper shielding body of LMFBR type reactors. Constitution: In an upper shielding body in which a large rotational plug is rotatably mounted to a circular hole formed at an eccentric position of a roof slab, while a small rotational plug is rotatably mounted to a circular hole disposed at an eccentric position of the large rotational plug and the reactor core upper mechanisms are supported on the small rotational plug, heat insulation layers are attached to the inside of the inner circumferential wall of the roof slab and the outer circumferential wall of the large rotational plug. By attaching the heat insulation layers, the heat conduction between the roof slab and the large rotational plug can be suppressed remarkably, by which occurrence of specific heat pass or local generation of large thermal stresses can be avoided even if difference is resulted to the temperature distribution between them. In this way, functions taking advantage of respective features of the roof slab and the small rotational plug can be obtained to achieve the purpose. (Kamimura, M.)

  9. Volume rejuvenation of the facial upper third.

    Science.gov (United States)

    Buckingham, Edward D; Glasgold, Robert; Kontis, Theda; Smith, Stephen P; Dolev, Yalon; Fitzgerald, Rebecca; Lam, Samuel M; Williams, Edwin F; Pollei, Taylor R

    2015-02-01

    The next three articles in this issue take a unique approach to discussing volumetric restoration. Robert Glasgold has provided an assessment for each facial region and five different renowned authors (TK, SPS, RF, SML, and EFW) have been asked to speak on a particular volumetric product, of which they are considered an expert, as it applies to the different regions of the face. The articles are broken into the following: (1) upper third which corresponds to the upper eyelid, brow, temple, and forehead; (2) middle third which will cover lower eyelid, cheek, and perioral area; and (3) lower third which discusses the marionette, prejowl, and jawline. Our hope is that by placing differing opinions of experienced authors, organized by facial region together, the reader will have the opportunity to more readily compare the options. The contributing authors and their product area are as follows: Theda Kontis, MD-hyaluronic acid; Steve Smith, MD-calcium hydroxyl appetite; Rebecca Fitzgerald, MD-poly-L lactic acid; Sam Lam, MD-polymethyl methacrylate; and Edwin Williams, MD-Autologous Fat Transfer. If the author included general comments on the product, they are included in the article on the upper face only and are not repeated. Please note that other individuals may also have significantly assisted in the production of these articles, but those listed above are the senior authors. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  10. Land Capability Evaluation of Upper Sekampung Watersheds

    Directory of Open Access Journals (Sweden)

    Irwan Sukri Banuwa

    2008-05-01

    Full Text Available Land degradation is a serious problem in the Upper Sekampung Watersheds. This is because the farmers cultivated in steep land to coffee crops without in adequate soil and water conservation practices. The land degradation is mostly caused by erosion. The erosion problem not only stripping the most fertile top soil and decreasing crop production, but also resulting problems in lowland. Therefore, the reorientation land management should be improved to produce agriculture sustainability. The first step is to evaluated land capability this area. The objectives of the research were evaluate land capability of Upper Sekampung Watersheds. The results showed that the Upper Sekampung Watersheds were dominated with class and subclass land capability of III-l2 about 17.630,51 ha (41,58%. All of the constrain for each land capability in this area is erosion hazard, especially land slope. From this research, cultivated land to coffee base crops were allowed in land capability II-l1.e1, III-l2, IV-l3, and VI-l4, with in adequate soil and water conservation practices. In contrary, the land capability of VII-l5 unsuitable for agriculture, they should be a nature or for conservation forest.

  11. Infantile lipofibromatosis of the upper limb

    Energy Technology Data Exchange (ETDEWEB)

    Teo, Harvey E.L.; Peh, Wilfred C.G. [KK Women' s and Children' s Hospital, Department of Diagnostic Imaging, Singapore (Singapore); Chan, Mei-Yoke [KK Women' s and Children' s Hospital, Department of Paediatric Medicine, Singapore (Singapore); Walford, Norman [Tan Tock Seng Hospital, Department of Pathology, Singapore (Singapore)

    2005-12-01

    The imaging features of extensive lipofibromatosis presenting in a 1-day-old female infant are reported. This lesion involved her entire right upper limb, extending from the axilla to the palm of the hand. Radiographs showed marked deformity and thinning of all the right upper-limb bones due to pressure effect of soft-tissue enlargement, especially affecting the distal humerus and proximal forearm bones. Magnetic resonance imaging showed a huge soft-tissue mass infiltrating most of the muscles of the entire upper limb, with bony erosion. The mass was largely T1-isointense, moderately T2-hyperintense and showed marked enhancement. There were intra-lesional signal changes consistent with fatty elements. A lesion debulking procedure was performed and the histology was that of lipofibromatosis. The limb was found to be non-viable after the procedure and a subsequent above-elbow amputation was performed. Although the resection margins were not clear, she had no further recurrence over a subsequent 3-year follow-up period. (orig.)

  12. Spacesuit Soft Upper Torso Sizing Systems

    Science.gov (United States)

    Graziosi, David; Splawn, Keith

    2011-01-01

    The passive sizing system consists of a series of low-profile pulleys attached to the front and back of the shoulder bearings on a spacesuit soft upper torso (SUT), textile cord or stainless steel cable, and a modified commercial ratchet mechanism. The cord/cable is routed through the pulleys and attached to the ratchet mechanism mounted on the front of the spacesuit within reach of the suited subject. Upon actuating the ratchet mechanism, the shoulder bearing breadth is changed, providing variable upper torso sizing. The active system consists of a series of pressurizable nastic cells embedded into the fabric layers of a spacesuit SUT. These cells are integrated to the front and back of the SUT and are connected to an air source with a variable regulator. When inflated, the nastic cells provide a change in the overall shoulder bearing breadth of the spacesuit and thus, torso sizing. The research focused on the development of a high-performance sizing and actuation system. This technology has application as a suit-sizing mechanism to allow easier suit entry and more accurate suit fit with fewer torso sizes than the existing EMU (Extravehicular Mobility Unit) suit system. This advanced SUT will support NASA s Advanced EMU Evolutionary Concept of a two-sizes-fit-all upper torso for replacement of the current EMU hard upper torso (HUT). Both the passive and nastic sizing system approaches provide astronauts with real-time upper torso sizing, which translates into a more comfortable suit, providing enhanced fit resulting in improved crewmember performance during extravehicular activity. These systems will also benefit NASA by reducing flight logistics as well as overall suit system cost. The nastic sizing system approach provides additional structural redundancy over existing SUT designs by embedding additional coated fabric and uncoated fabric layers. Two sizing systems were selected to build into a prototype SUT: one active and one passive. From manned testing, it

  13. Promise(s of mesenchymal stem cells as an in vitro model system to depict pre-diabetic/diabetic milieu in WNIN/GR-Ob mutant rats.

    Directory of Open Access Journals (Sweden)

    Soundarya L Madhira

    Full Text Available BACKGROUND: Development of model systems have helped to a large extent, in bridging gap to understand the mechanism(s of disease including diabetes. Interestingly, WNIN/GR-Ob rats (Mutants, established at National Centre for Laboratory Animals (NCLAS of National Institute of Nutrition (NIN, form a suitable model system to study obesity with Type 2 diabetes (T2D demonstrating several secondary complications (cataract, cardiovascular complications, infertility, nephropathy etc. The present study has been carried out to explore the potent application(s of multipotent stem cells such as bone marrow mesenchymal stem cells (BM-MSCs, to portray features of pre-diabetic/T2D vis-à-vis featuring obesity, with impaired glucose tolerance (IGT, hyperinsulinemia (HI and insulin resistance (IR seen with Mutant rats akin to human situation. METHODOLOGY/PRINCIPAL FINDINGS: Primary cultures of BM-MSCs (third passage from Mutants, its lean littermate (Lean and parental control (Control were characterized for: proliferation markers, disease memory to mark obesity/T2D/HI/IR which included phased gene expression studies for adipogenic/pancreatic lineages, inflammatory markers and differentiation ability to form mature adipocytes/Insulin-like cellular aggregates (ILCAs. The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNFα; increased stem cell recruitment (Oct-4, Sox-2 and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation; accelerated preadipocyte induction (Dact-1, PPARγ2 with a quantitative increase in mature adipocyte formation (Leptin; ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants. Further, these observations were in compliance with the anthropometric data. CONCLUSIONS: Given the ease of accessibility and availability of MSCs, the present study form the basis to report for

  14. Abrasiveness and hardness of rocks of Cretaceous deposits of Chechen-Ingushetiya. Ob abrazivnosti i tverdosti gornykh porod melovykh otlozhenii Checheno-Ingushetii

    Energy Technology Data Exchange (ETDEWEB)

    Trofimenko, Yu.P.

    1981-01-01

    Presented are results of studies of the abrasiveness and hardness of core material taken from Upper Cretaceous deposits in the process of drilling deep boreholes in the areas of Chechen-Ingushetiya. Based on the studies it is established that the abrasiveness of rock is mainly influenced by the coarseness of the mineral grains in the rock, their mineralogical composition, and the composition of the cement. Given is a system of clasification of the investigated core material with respect to abrasiveness and hardness.

  15. A survey of medicinal plants around upper Songkhla lake, Thailand ...

    African Journals Online (AJOL)

    A survey of medicinal plants around upper Songkhla lake, Thailand. ... method of preparation, route of administration and properties of plants. ... Keywords: Medicinal plant, Ethnobotany, Traditional medicine, Upper Songkhla Lake, Thailand ...

  16. Arterial variations of upper limb: a case report

    Directory of Open Access Journals (Sweden)

    Vollala V

    2005-01-01

    Full Text Available Variations of upper limb arteries are common and there are many reports about this subject. We report multiple variations in arterial pattern of upper extremity, which were encountered in a single cadaver.

  17. Advanced upper limb prosthetic devices: implications for upper limb prosthetic rehabilitation.

    Science.gov (United States)

    Resnik, Linda; Meucci, Marissa R; Lieberman-Klinger, Shana; Fantini, Christopher; Kelty, Debra L; Disla, Roxanne; Sasson, Nicole

    2012-04-01

    The number of catastrophic injuries caused by improvised explosive devices in the Afghanistan and Iraq Wars has increased public, legislative, and research attention to upper limb amputation. The Department of Veterans Affairs (VA) has partnered with the Defense Advanced Research Projects Agency and DEKA Integrated Solutions to optimize the function of an advanced prosthetic arm system that will enable greater independence and function. In this special communication, we examine current practices in prosthetic rehabilitation including trends in adoption and use of prosthetic devices, financial considerations, and the role of rehabilitation team members in light of our experiences with a prototype advanced upper limb prosthesis during a VA study to optimize the device. We discuss key challenges in the adoption of advanced prosthetic technology and make recommendations for service provision and use of advanced upper limb prosthetics. Rates of prosthetic rejection are high among upper limb amputees. However, these rates may be reduced with sufficient training by a highly specialized, multidisciplinary team of clinicians, and a focus on patient education and empowerment throughout the rehabilitation process. There are significant challenges emerging that are unique to implementing the use of advanced upper limb prosthetic technology, and a lack of evidence to establish clinical guidelines regarding prosthetic prescription and treatment. Finally, we make recommendations for future research to aid in the identification of best practices and development of policy decisions regarding insurance coverage of prosthetic rehabilitation. Copyright © 2012 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  18. Doppiaggio in italiano del film 'Astérix et Obélix - Au service de Sa Majesté'. Trasposizione degli elementi culturali e umoristici

    Directory of Open Access Journals (Sweden)

    Alessandra Rollo

    2016-01-01

    Full Text Available Abstract – At present, audiovisual translation is one of the most interesting and stimulating domains within the field of Translation Studies. Resting on a rich semiotic apparatus, marked by the interplay of a double channel of communication – audio/visual – with different types of signs – verbal/non-verbal codes, the audiovisual text is a complex one, whose transfer from one language into another represents a challenging task for every professional in this field. Especially in dubbing, the translator/adapter has to work on the interlinguistic level as well as on the intersemiotic level (iconic, paralinguistic elements, etc.: as many codes having great semantic potential and transmitting useful cultural information, as we shall see in the film which we have taken as the object of our analyses: Astérix et Obélix: Au Service de Sa Majesté (2012. This fourth film adaptation (except cartoons of Astérix’s adventures offers a series of gags playing on the parody of typical traditions, symbols, linguistic clichés and cultural stereotypes associated with British culture. Italian dubbing resorts to different translation strategies, some of which come under a foreignizing approach, aiming at preserving the original’s colour and mood, whereas others are in line with a domesticating approach, in order to bring the product closer to the final audience. Indeed, instead of stressing the idea of a polarization or a dichotomy between two contrasting perspectives, we find it advisable to envisage a gradation between two instances which occur at the same time and coexist in a complementary way during the translation process.   Keywords: audiovisual translation; dubbing; cultural elements; humorous elements; foreignization/domestication.     Résumé – La traduction audiovisuelle se configure à l’heure actuelle comme l’un des domaines les plus intéressants et les plus stimulants dans le panorama des etudes traductologiques. Reposant sur

  19. Biogeochemical migration of heavy metals, Ti, V, Mo, Ta, W, and U, in the profile of a low-laid peatbog in the country between the Ob and Tom rivers

    International Nuclear Information System (INIS)

    Efremova, T.T.; Efremov, S.P.; Koutsenogii, K.P.; Peresedov, V.F.

    2003-01-01

    Biogeochemical migration of heavy metals in the course of marsh formation is mainly determined by physical-chemical processes, such as the oxidation-reduction zonality of the peatbog thickness and the state of humous substances (the quality of humus adsorptive barriers). In the process of peatbog formation V, U, Ta are the weakly captured elements while Mo is captured to a relatively higher extent. Elements as Ti and W are found in separate layers. No technogenic degradation of the marsh ecosystem in the Ob and Tom has been observed. (author)

  20. Ocena prostorske razsežnosti žledoloma februarja 2014 v bukovih in smrekovih sestojih v občinah Tolmin in Dobrova - Polhov Gradec s pomočjo tehnologije daljinskega zaznavanja

    OpenAIRE

    Šafran, Aljoša

    2018-01-01

    V magistrskem delu obravnavamo žledolom, ki je ob koncu januarja in začetku februarja 2014 povzročil gmotno škodo ne le na vegetaciji, temveč tudi na energetski in železniški infrastrukturi. Po dosedanjih ocenah gre za enega izmed najobsežnejših žledolomov na območju Slovenije v zadnjih desetletjih. V raziskavi nas je zanimala prostorska razporeditev sprememb v biomasi bukovih in smrekovih sestojev na z žledom prizadetih območjih, zaznanih s pomočjo satelita Landsat. V raziskavo sta bili zaje...