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Sample records for unmasks occult stress

  1. Management of occult stress urinary incontinence with prolapse surgery.

    Science.gov (United States)

    Al-Mandeel, H; Al-Badr, A

    2013-08-01

    Pelvic organ prolapse (POP) and stress urinary incontinence (SUI), are two common health-related conditions, each affecting up to 50% women worldwide. Stress urinary incontinence only observed after the reduction of co-existent prolapse is called occult SUI (OSUI), and is found in up to 80% of women with advanced POP. Although there is no consensus on how to diagnose OSUI, there are several reported methods to better diagnose. Counseling symptomatically continent women with POP concerning the potential risk for developing SUI postoperatively cannot be overstated. Evidence suggests that positive OSUI in symptomatically continent women who are planning to have POP repair is associated with a high risk of POSUI, furthermore, adding continence procedure is found to reduce postoperative SUI. Therefore, adding continence surgery at the time of POP surgery in patients who are found to have OSUI preoperatively is advocated.

  2. EFFECTIVE WAYS TO MANAGE STRESS AND UNMASK THE ABILITIES OF PEOPLE WITH ASPERGER’S SYNDROME

    OpenAIRE

    Riichiro Ishida

    2013-01-01

    People with Asperger’s syndrome often have superior abilities in various fields, including art, natural science, and solving social problems. However, they tend to become stressed easily due to difficulties in relating to others. This stress sometimes prevents them from showing their full potential. Their abilities and tendency to become stressed are similar to those of people with schizoid temperament. Recent evidence has shown that purpose in life (PIL)/ikigai, moderate aerobic exercise, an...

  3. EFFECTIVE WAYS TO MANAGE STRESS AND UNMASK THE ABILITIES OF PEOPLE WITH ASPERGER’S SYNDROME

    Directory of Open Access Journals (Sweden)

    Riichiro Ishida

    2013-07-01

    Full Text Available People with Asperger’s syndrome often have superior abilities in various fields, including art, natural science, and solving social problems. However, they tend to become stressed easily due to difficulties in relating to others. This stress sometimes prevents them from showing their full potential. Their abilities and tendency to become stressed are similar to those of people with schizoid temperament. Recent evidence has shown that purpose in life (PIL/ikigai, moderate aerobic exercise, and diet, which are related to each other and to prefrontal lobe function, are effective methods for coping with stress. PIL/ikigai, which is an attitude in which one seeks to establish meaning of life, is developed through positive experiences, such as cordial human relations with suitable role-models, spending time in beautiful natural surroundings, and being moved by people or events. PIL/ikigai for people without schizoid temperament develops through such positive experiences throughout their life. However, PIL/ikigai for people with schizoid temperament/Asperger’s syndrome develops through positive experiences during a limited number of life stages: infancy, childhood, and adulthood. Moderate aerobic exercise, such as walking, running, and swimming, were linked to finding food during the evolution of mankind. In turn, our diet supplies nutrients to our organs. Therefore, we propose that providing positive experiences during the critical periods and maturation periods of particular brain regions may influence PIL/ikigai, which is related to moderate aerobic exercise and diet. This process may help people with Asperger’s syndrome to demonstrate their full potential abilities and to contribute to various fields.

  4. Unmasking of Partial Diabetes Insipidus during Stress but Not Maintenance Dosing of Glucocorticoids in an Infant with Septo-Optic Dysplasia

    Directory of Open Access Journals (Sweden)

    Loechner KarenJ

    2011-03-01

    Full Text Available Background. It is well acknowledged that glucocorticoid (GC replacement can unmask diabetes insipidus (DI in subjects with hypopituitarism. Objective. To increase the awareness and monitoring for transient and symptomatic DI in children with partial hypopituitarism during periods in which increased GC needs are required. Methods/Case. A 2-month-old female infant with septo-optic dysplasia (SOD; on thyroid and maintenance GC replacement therapy at 8 mg/m2/day developed transient DI during 2 separate episodes of stress (one hypothermia, one febrile when stress dosing of GC (25 mg/m2/day was instituted. Conclusion. Children not diagnosed with DI during initial evaluation for hypopituitarism may benefit from rescreening of serum sodium levels during acute periods of stress that demand "stress" GC dosing. This will permit treatment and/or increased vigilance for ensuing permanent DI.

  5. Adolescent social isolation stress unmasks the combined effects of adolescent exercise and adult inflammation on hippocampal neurogenesis and behavior.

    Science.gov (United States)

    Hueston, Cara M; Cryan, John F; Nolan, Yvonne M

    2017-12-04

    Hippocampal neurogenesis and associated cognitive behaviors are regulated by a number of factors including stress, inflammation, and exercise. However, the interplay between these factors remains relatively unexplored, especially across the lifespan. In the current study, the effect of social isolation stress during the adolescent period on neurogenesis and hippocampal-dependent cognitive behaviors was examined. This period of the lifespan has been demonstrated to be an important time for hippocampal growth and plasticity, during which changes to hippocampal neurogenesis may have long lasting effects. Additionally, we aimed to determine whether a 'dual-hit' of adolescent stress and adult chronic neuroinflammation would potentiate any negative effects of either insult alone. Lastly, the potential positive effects of exercise during adolescence was examined to determine whether exercise could attenuate any negative impacts of these insults on hippocampal neurogenesis and behavior. The results from the current study demonstrate that social isolation stress during adolescence followed by intra-hippocampal exposure to the pro-inflammatory cytokine IL-1β in early adulthood produces deficits in both spontaneous alternations and novel object recognition. Exercise attenuated deficits in neurogenesis and novel object recognition in mice that had been exposed to the 'dual-hit' of stress and neuroinflammation. These findings indicate that adolescence represents a key period of the lifespan during which external factors such as stress and exercise can impact on hippocampal development, and may alter the response to challenges such as neuroinflammation in later life. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

  6. Vaginal prolapse repair with or without a midurethral sling in women with genital prolapse and occult stress urinary incontinence: a randomized trial.

    Science.gov (United States)

    van der Ploeg, J Marinus; Oude Rengerink, Katrien; van der Steen, Annemarie; van Leeuwen, Jules H Schagen; van der Vaart, C Huub; Roovers, Jan-Paul W R

    2016-07-01

    We compared pelvic organ prolapse (POP) repair with and without midurethral sling (MUS) in women with occult stress urinary incontinence (SUI). This was a randomized trial conducted by a consortium of 13 teaching hospitals assessing a parallel cohort of continent women with symptomatic stage II or greater POP. Women with occult SUI were randomly assigned to vaginal prolapse repair with or without MUS. Women without occult SUI received POP surgery. Main outcomes were the absence of SUI at the 12-month follow-up based on the Urogenital Distress Inventory and the need for additional treatment for SUI. We evaluated 231 women, of whom 91 randomized as follows: 43 to POP surgery with and 47 without MUS. A greater number of women in the MUS group reported absence of SUI [86 % vs. 48 %; relative risk (RR) 1.79; 95 % confidence interval (CI) 1.29-2.48]. No women in the MUS group received additional treatment for postoperative SUI; six (13 %) in the control group had a secondary MUS. Women with occult SUI reported more urinary symptoms after POP surgery and more often underwent treatment for postoperative SUI than women without occult SUI. Women with occult SUI had a higher risk of reporting SUI after POP surgery compared with women without occult SUI. Adding a MUS to POP surgery reduced the risk of postoperative SUI and the need for its treatment in women with occult SUI. Of women with occult SUI undergoing POP-only surgery, 13 % needed additional MUS. We found no differences in global impression of improvement and quality of life.

  7. Vaginal prolapse repair with or without a midurethral sling in women with genital prolapse and occult stress urinary incontinence: a randomized trial

    NARCIS (Netherlands)

    van der Ploeg, J. Marinus; Oude Rengerink, Katrien; van der Steen, Annemarie; van Leeuwen, Jules H. Schagen; van der Vaart, C. Huub; Roovers, Jan-Paul W. R.

    2016-01-01

    We compared pelvic organ prolapse (POP) repair with and without midurethral sling (MUS) in women with occult stress urinary incontinence (SUI). This was a randomized trial conducted by a consortium of 13 teaching hospitals assessing a parallel cohort of continent women with symptomatic stage II or

  8. Vaginal prolapse repair with or without a midurethral sling in women with genital prolapse and occult stress urinary incontinence : a randomized trial

    NARCIS (Netherlands)

    van der Ploeg, J Marinus; Rengerink, Katrien Oude; van der Steen, Annemarie; van Leeuwen, Jules H Schagen; van der Vaart, C Huub; Roovers, Jan-Paul W R

    INTRODUCTION AND HYPOTHESIS: We compared pelvic organ prolapse (POP) repair with and without midurethral sling (MUS) in women with occult stress urinary incontinence (SUI). METHODS: This was a randomized trial conducted by a consortium of 13 teaching hospitals assessing a parallel cohort of

  9. Asymptomatic myotonia congenita unmasked by severe hypothyroidism.

    Science.gov (United States)

    Passeri, Elena; Sansone, Valeria A; Verdelli, Chiara; Mendola, Marco; Corbetta, Sabrina

    2014-04-01

    Myotonia congenita is an inherited muscle disorder sustained by mutations in the skeletal muscle chloride channel gene CLCN1. Symptoms vary from mild to severe and generalized myotonia and worsen with cold, stressful events and hormonal fluctuations. Here we report the case of a young woman who sought medical attention because of subacute onset of diffuse and severe limb myotonia. CLCN1 gene sequencing showed a heterozygous transversion (T550M), two polymorphisms and one silent mutation. Thyroid function screening revealed severe hypothyroidism. She was placed on l-thyroxine replacement therapy which dramatically improved myotonia. We conclude that hypothyroidism unmasked a genetically determined, clinically asymptomatic chloride channelopathy. Diagnostic work-up in patients with clinically isolated myotonia should not be limited to genetic screening of non-dystrophic or dystrophic myotonias. Considering the high prevalence of hypothyroidism in females, systematic thyroid function screening by looking for additional hypothyroid symptoms and serum TSH levels measurement is mandatory in these patients. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Unmasking Abilities Hidden by Developmental Conditions.

    Science.gov (United States)

    Mallik, Kalisankar, Ed.; Shaver, Elaine M., Ed.

    This document contains 16 papers that were scheduled to be presented at a conference (which was canceled) on approaches and programs for helping developmentally disabled persons to be more self-sufficient. The book is divided into three sections: (1) unmasking vocational abilities, (2) enhancing functional independence, and (3) medical and…

  11. Unmasking of Brugada syndrome by lithium

    NARCIS (Netherlands)

    Darbar, Dawood; Yang, Tao; Churchwell, Keith; Wilde, Arthur A. M.; Roden, Dan M.

    2005-01-01

    Background - The characteristic ECG pattern of ST- segment elevation in V-1 and V-2 in the Brugada syndrome is dynamic; it is often intermittently present in affected individuals and can be unmasked by sodium channel blockers, including antiarrhythmic drugs and tricyclic antidepressants. We report

  12. Measurement of stellar occultations

    Science.gov (United States)

    Eberle, Andreas

    2008-09-01

    Whenever an asteroid occults a star, we have the opportunity to study that asteroid in great detail. As frequently shown in the past, amateur astronomers1 have the necessary equipment to measure such events successfully2. Combined with the dense net of amateur observatories and online coordination tools3 for movable stations, they can create fine grids to detect even small bodies. The analysis of these events gives us the possibility to receive high precision astrometry data, to determine the asteroids size and shape (and therefore its albedo), and even to collect information on the star itself.4 While usually a set of several light curves is required to do so, a single recording5 of (10734) Wieck's occultation of HIP 22157 on 2008 Feb 08 was sufficient to retrieve the necessary data6. 1 Observation campaigns are organized by the International Occultation Timing Association (IOTA), http://www.iota-es.de/ 2 for results see e.g. euraster.net by E. Frappa, http://www.euraster.net/ 3 Occult Watcher by H. Pavlov, http://www.hristopavlov.net/OccultWatcher/OccultWatcher.html 4 see K. Miyashita's analysis of the observation of the occultation of TYC 1886-01206-1 by Kalliope and Linus, http://www005.upp.so-net.ne.jp/k miyash/occ02/kalliope/doublestar en.html 5 recording obtained by H. Michels, MPC Station Code 240 6 using Limovie by K. Miyashita

  13. [Study on reductive surgery for pelvic organ prolapse concomitant with anti-incontinence sling for treatment of occult stress urinary incontinence].

    Science.gov (United States)

    Zhang, Xiaolong; Lu, Yongxian; Shen, Wenjie; Liu, Jingxia; Ge, Jing; Liu, Xin; Zhao, Ying; Niu, Ke; Zhang, Yinghui; Wang, Wenying; Qiu, Chengli

    2014-06-01

    To evaluate the clinical outcome of anti-incontinence sling in the treatment of occult stress urinary incontinence (OSUI) during reductive surgery for advanced pelvic organ prolapse (POP). From Jun. 2003 to Dec. 2012, 78 patients with OSUI underwent reductive surgery for advanced POP such as high uterosacral ligament suspension, sacrospinous ligament suspension and sacral colpopexy in the First Affiliated Hospital, General Hospital of People's Liberation Army. Among them, 41 patients received reductive surgery alone was enrolled in non-concomitant anti-incontinence group and the other 37 patients who underwent same surgery with tension-free vaginal tape (TVT) or tension-free vaginal tape-obturator technique (TVT-O) was in anti-incontinence group. The patient's demography, objective and subjective outcomes, as well as complications and injures were compared between the two groups. The pelvic organ prolapse quantitation (POP-Q) was used to evaluate the objective outcomes of POP. Urinary distress inventory (UDI-6) and incontinence impact questionnaire short form (IIQ-7) were used to evaluate the subjective outcomes of stress urinary incontinence (SUI). Compared with the non-concomitant anti-incontinence group, the objective outcomes of reductive surgery exhibited no significant differences (100%, 78/78), and only the operation time of anti-incontinence group slightly increased 16 minutes. The occurrence rate of postoperative SUI was 12% (5/41), 15% (6/41), 17% (7/41) respectively after the operation at 2-month, 6-month and 12-month follow up in the non-concomitant anti-incontinence group; and the occurrence rate of the anti-incontinence group was 3% (1/37), 3% (1/37), 3% (1/37); but none of patients in the two groups require further surgery for stress urinary incontinence. Mean score of UDI-6 and IIQ-7 in all the patients decreased significantly after operation at 2-month, 6-month and 12-month follow up (all P statistic difference between the two groups (P > 0.05). It

  14. Unmasking sarcoidosis following surgery for Cushing disease

    DEFF Research Database (Denmark)

    Diernæs, Jon Erik; Bygum, Anette; Poulsen, Per L

    2016-01-01

    We present a patient with Cushing disease apparently suppressing sarcoidosis, which was unmasked following surgical resection of a pituitary adrenocorticotropin (ACTH)-producing microadenoma. Case report and a short review of the literature published in this area. A 46-year-old Caucasian woman pr...... successful treatment of Cushing syndrome may have a flare-up or emergence of a corticosteroid-responsive disease.......We present a patient with Cushing disease apparently suppressing sarcoidosis, which was unmasked following surgical resection of a pituitary adrenocorticotropin (ACTH)-producing microadenoma. Case report and a short review of the literature published in this area. A 46-year-old Caucasian woman...... for which the patient underwent transphenoidal resection. Maintenance corticosteroid therapy was implemented, and the signs and symptoms of Cushing disease began to resolve. Three months after surgery, multiple erythematous painful nodules developed on the patient's arms. Erythema nodosum (EN) was diagnosed...

  15. [POP-Q indication points, Aa and Ba, involve in diagnosis and prognosis of occult stress urinary incontinence complicated with pelvic organ prolapse].

    Science.gov (United States)

    Liu, Cheng; Wu, Wenying; Yang, Qing; Hu, Ming; Zhao, Yang; Hong, Li

    2015-06-01

    To investigate the correlation between pelvic organ prolapse quantitation (POP-Q) indication points and the incidence of occult stress urinary incontinence (OSUI) and its impact on prognosis. Retrospective study medical records of 93 patients with pelvic organ prolapse (POP) staged at III-IV, of which underwent pelvic reconstruction operations with Prolift system from Jan. 2007 to Sept. 2012. None of these patients had clinical manifestations of stress urinary incontinence (SUI) before surgery, and in which 44 patients were included in study group (POP complicated with OSUI) because they were identified with OSUI, another 49 patients as control group (simple POP). Follow-up and collecting datas including POP-Q, stress test, urodynamic recordings, incidence of de novo SUI, statistic analyzing by logistic regression and receiver operating characteristic curve (ROC). (1) The study group had a much higher incidence of 30% (13/44) on de novo SUI than that of control group (4%, 2/49; P < 0.01). (2) Vaginal delivery (OR = 5.327, 95% CI: 1.120-25.347), constipation (OR = 5.789, 95% CI: 1.492-22.459), preoperative OSUI (OR = 13.695, 95% CI: 2.980-62.944), anterior vaginal wall prolapse (OR = 6.115, 95% CI: 1.231-30.379) were identified as dependent risk factors for de novo SUI by logistic regression analysis. (3) For POP patients that complicated with OSUI, we chose a cutoff value of +1.5 cm for Aa point as the threshold to predicting incidence of de novo SUI according to ROC curve, area under the curve (AUC) was 0.889 (P < 0.05), the sensitivity reached 88.9% and specificity was 73.9%. According to ROC curve of Ba point, a cutoff value of +2.5 cm was chosen as the threshold to predicting incidence of de novo SUI post-operation, it had a sensitivity of 66.7% and specificity of 82.6%, AUC was 0.766 (P < 0.05). Pre-operative OSUI is a dependent risk factor of de novo SUI for advanced POP patients. Aa and Ba points are correlated with preoperative OSUI, and it is worthy to be

  16. Development of a Single High Fat Meal Challenge to Unmask ...

    Science.gov (United States)

    Stress tests are used clinically to determine the presence of underlying disease and predict future cardiovascular risk. In previous studies, we used treadmill exercise stress in rats to unmask the priming effects of air pollution inhalation. Other day-to-day activities stress the cardiovascular system, and when modeled experimentally, may be useful in identifying latent effects of air pollution exposure. For example, a single high fat (HF) meal can cause transient vascular endothelial dysfunction and increases in LDL cholesterol, triglycerides (TG), oxidative stress, and inflammation. Given the prevalence of HF meals in western diets, the goal of this study was to develop a HF meal challenge in rats to see if air pollution primes the body for a subsequent stress-induced adverse response. Healthy male Wistar Kyoto rats were fasted for six hours and then administered a single oral gavage of isocaloric lard-based HF or low fat (LF) suspensions, or a water vehicle control. We hypothesized that rats given a HF load would elicit postprandial changes in cardiopulmonary function that were distinct from LF and vehicle controls. One to four hours after gavage, rats underwent whole body plethysmography to assess breathing patterns, cardiovascular ultrasounds, blood draws for measurements of systemic lipids and hormones and a test for sensitivity to aconitine-induced arrhythmia. HF gavage caused an increase in circulating TG relative to LF and vehicle controls and an incre

  17. Late-onset urea cycle disorder in adulthood unmasked by severe malnutrition.

    Science.gov (United States)

    Wells, Diana L; Thomas, Jillian B; Sacks, Gordon S; Zouhary, L Anna

    2014-01-01

    Urea cycle disorders (UCDs) most often involve inherited deficiencies in genes that code for enzymes normally used by the urea cycle to breakdown nitrogen. UCDs lead to serious metabolic complications, including severe neurologic decompensation related to hyperammonemia. Although the majority of UCDs are revealed soon after birth, stressful events in adulthood can lead to unmasking of a partial, late-onset UCDs. In this report, we describe a late-onset UCD unmasked by severe malnutrition. Early, specialized nutrition therapy is a fundamental aspect of treating hyperammonemic crises in patients with UCD. The case presented here demonstrates the importance of early recognition of UCD and appropriate interventions with nutrition support. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Occult spinal dysraphism

    African Journals Online (AJOL)

    paediatricians, paediatric neurosurgeons, urologists, orthopaedic surgeons, occupational ... Occult spinal dysraphism refers to a diverse group of congenital abnormalities resulting from varying degrees of disordered neuro- embryogenesis. Several terms have .... can image the whole spine. T1-weighted sagittal and axial ...

  19. Poliosis circumscripta unmasking a scalp melanoma.

    Science.gov (United States)

    Yeo, L; Husain, E; Rajpara, S

    2015-12-01

    A 28-year-old man presented with a 1-year history of a localized patch of grey hair and an underlying darkly pigmented lesion on his right occipital area. Clinical appearance revealed poliosis overlying an asymmetrical plaque with variable degrees of brown pigmentation and white discolouration. Owing to the suspicious nature of the lesion, excision with a 2 mm margin was performed. Histology revealed an invasive melanoma with extensive regression and prominent involvement of multiple hair follicles. Scalp melanoma with associated poliosis is extremely rare, and has only been reported once in the literature to date. There have been two reports in the opthalmology literature regarding eyelash poliosis associated with orbital melanoma. The pathogenesis of poliosis still remains unclear. This is the second reported case of poliosis circmscripta unmasking a scalp melanoma, and highlights the importance of being vigilant when examining patients with poliosis of the scalp. © 2014 British Association of Dermatologists.

  20. Occult Macular Dystrophy

    Directory of Open Access Journals (Sweden)

    Işıl Sayman Muslubaş

    2016-04-01

    Full Text Available Occult macular dystrophy is an inherited macular dystrophy characterized by a progressive decline of bilateral visual acuity with normal fundus appearance, fluorescein angiogram and full-field electroretinogram. This case report presents a 20-year-old female patient with bilateral progressive decline of visual acuity for six years. Her visual acuity was 3-4/10 in both eyes. Anterior segment and fundus examination, fluorescein angiogram and full-field electroretinogram were normal. She could read all Ishihara pseudoisochromatic plates. Fundus autofluorescence imaging was normal. There was a mild central hyporeflectance on fundus infrared reflectance imaging in both eyes. Reduced foveal thickness and alterations of the photoreceptor inner and outer segment junction were observed by optical coherence tomography in both eyes. Central scotoma was also found by microperimetry and reduced central response was revealed by multifocal electroretinogram in both eyes. These findings are consistent with the clinical characteristics of occult macular dystrophy

  1. Occult carbon monoxide poisoning.

    Science.gov (United States)

    Kirkpatrick, J N

    1987-01-01

    A syndrome of headache, fatigue, dizziness, paresthesias, chest pain, palpitations and visual disturbances was associated with chronic occult carbon monoxide exposure in 26 patients in a primary care setting. A causal association was supported by finding a source of carbon monoxide in a patient's home, workplace or vehicle; results of screening tests that ruled out other illnesses; an abnormally high carboxyhemoglobin level in 11 of 14 patients tested, and abatement or resolution of symptoms when the source of carbon monoxide was removed. Exposed household pets provided an important clue to the diagnosis in some cases. Recurrent occult carbon monoxide poisoning may be a frequently overlooked cause of persistent or recurrent headache, fatigue, dizziness, paresthesias, abdominal pain, diarrhea and unusual spells.

  2. Occult Carbon Monoxide Poisoning

    OpenAIRE

    Kirkpatrick, John N.

    1987-01-01

    A syndrome of headache, fatigue, dizziness, paresthesias, chest pain, palpitations and visual disturbances was associated with chronic occult carbon monoxide exposure in 26 patients in a primary care setting. A causal association was supported by finding a source of carbon monoxide in a patient's home, workplace or vehicle; results of screening tests that ruled out other illnesses; an abnormally high carboxyhemoglobin level in 11 of 14 patients tested, and abatement or resolution of symptoms ...

  3. Occult pneumothorax, revisited

    OpenAIRE

    Mangar Devanand; Abdelmalak Hany; Omar Hesham R; Rashad Rania; Helal Engy; Camporesi Enrico M

    2010-01-01

    Abstract Pneumothorax is a recognized cause of preventable death following chest wall trauma where a simple intervention can be life saving. In cases of trauma patients where cervical spine immobilization is mandatory, supine AP chest radiograph is the most practical initial study. It is however not as sensitive as CT chest for early detection of a pneumothorax. "Occult" pneumothorax is an accepted definition of an existing but usually a clinically and radiologically silent disturbance that i...

  4. GAMBARAN RADIOLOGIS PADA OCCULT PNEUMOTHORAKS

    Directory of Open Access Journals (Sweden)

    Putu Aditha Satya Putra

    2013-02-01

    Full Text Available Pneumothorax is a recognized cause of death in chest wall trauma. Radiological examination is the key factor to establish the existence of a pneumothorax. Occult pneumothorax is pneumothorax that undiagnosed clinically and with thoracic x-ray, but it can be tolerated while other more urgent trauma. Occult pneumothorax can be detected by CT (Computed tomography. Occult pneumothorax may progress to tension pneumothorax in certain circumstances. Missing in diagnosed pneumothorax will cause death. This literature will discuss radiological examination for diagnosing, early detection, and management of occult pneumothorax. If thoracic x-ray examination did not reveal the occult pneumothorax, it can be dangerous if existence of pneumothorax was not known. In this case, the examination of thoracic CT-Scan is gold standard for determining the presence of occult pneumothorax and can provide appropriate care.

  5. GAMBARAN RADIOLOGIS PADA OCCULT PNEUMOTHORAKS

    OpenAIRE

    Putu Aditha Satya Putra; Nyoman Srie Laksminingsih

    2013-01-01

    Pneumothorax is a recognized cause of death in chest wall trauma. Radiological examination is the key factor to establish the existence of a pneumothorax. Occult pneumothorax is pneumothorax that undiagnosed clinically and with thoracic x-ray, but it can be tolerated while other more urgent trauma. Occult pneumothorax can be detected by CT (Computed tomography). Occult pneumothorax may progress to tension pneumothorax in certain circumstances. Missing in diagnosed pneumothorax will cause deat...

  6. Unmasking sarcoidosis following surgery for Cushing disease.

    Science.gov (United States)

    Diernaes, Jon E F; Bygum, Anette; Poulsen, Per L

    2016-01-01

    We present a patient with Cushing disease apparently suppressing sarcoidosis, which was unmasked following surgical resection of a pituitary adrenocorticotropin (ACTH)-producing microadenoma. Case report and a short review of the literature published in this area. A 46-year-old Caucasian woman presented with symptoms of hypercortisolism such as progressive weight gain, Cushingoid appearance, proximal myopathy, easy bruising, and amenorrhea. Blood testing including inferior petrosal sinus sampling uncovered an ACTH-producing microadenoma in the right aspect of the anterior pituitary gland for which the patient underwent transphenoidal resection. Maintenance corticosteroid therapy was implemented, and the signs and symptoms of Cushing disease began to resolve. Three months after surgery, multiple erythematous painful nodules developed on the patient's arms. Erythema nodosum (EN) was diagnosed clinically and a suspicion of underlying sarcoidosis was substantiated by lung imaging and elevated plasma interleukin (IL)-2 receptor. One month later, the lesions spontaneously resolved without therapy other than maintenance glucocorticoid replacement. Physicians should be aware that patients undergoing successful treatment of Cushing syndrome may have a flare-up or emergence of a corticosteroid-responsive disease.

  7. Unmasking the social engineer the human element of security

    CERN Document Server

    Hadnagy, Christopher

    2014-01-01

    Learn to identify the social engineer by non-verbal behavior Unmasking the Social Engineer: The Human Element of Security focuses on combining the science of understanding non-verbal communications with the knowledge of how social engineers, scam artists and con men use these skills to build feelings of trust and rapport in their targets. The author helps readers understand how to identify and detect social engineers and scammers by analyzing their non-verbal behavior. Unmasking the Social Engineer shows how attacks work, explains nonverbal communications, and demonstrates with visuals the c

  8. Beamsteerable GNSS Radio Occultation ASIC

    Data.gov (United States)

    National Aeronautics and Space Administration — We will develop an integrated RF ASIC to enable high quality radio occultation (RO) weather observations using the Global Navigations System Satellite (GNSS)...

  9. Occult Phenomena in Sherlock Holmes the Movie

    OpenAIRE

    NAMAZCARRA, CHRIESHER

    2014-01-01

    Keywords: Occult phenomena, Sherlock Holmes, movie. Lately, it is not difficult for people to find occult practices. There are many television programs and movie which air mystical programme aggressively to raise the rating and attract the viewers. A movie that raise occultism theme is Sherlock Holmes, the Movie. This movie tells about the struggle of detective Sherlock Holmes to fight the black magic power of Lord Blackwood.To carry out the study, the theories of Occultism such as the secrec...

  10. Pre- and Postoperative Binaural Unmasking for Bimodal Cochlear Implant Listeners.

    Science.gov (United States)

    Sheffield, Benjamin M; Schuchman, Gerald; Bernstein, Joshua G W

    Cochlear implants (CIs) are increasingly recommended to individuals with residual bilateral acoustic hearing. Although new hearing-preserving electrode designs and surgical approaches show great promise, CI recipients are still at risk to lose acoustic hearing in the implanted ear, which could prevent the ability to take advantage of binaural unmasking to aid speech recognition in noise. This study examined the tradeoff between the benefits of a CI for speech understanding in noise and the potential loss of binaural unmasking for CI recipients with some bilateral preoperative acoustic hearing. Binaural unmasking is difficult to evaluate in CI candidates because speech perception in noise is generally too poor to measure reliably in the range of signal to noise ratios (SNRs) where binaural intelligibility level differences (BILDs) are typically observed (binaural benefit, 9 out of 10 listeners tested postoperatively had performance equal to or better than their best pre-CI performance. The listener who retained functional acoustic hearing in the implanted ear also demonstrated a preserved acoustic BILD postoperatively. Approximately half of the CI candidates in this study demonstrated preoperative binaural hearing benefits for audiovisual speech perception in noise. Most of these listeners lost their acoustic hearing in the implanted ear after surgery (using nonhearing-preservation techniques), and therefore lost access to this binaural benefit. In all but one case, any loss of binaural benefit was compensated for or exceeded by an improvement in speech perception with the CI. Evidence of a preoperative BILD suggests that certain CI candidates might further benefit from hearing-preservation surgery to retain acoustic binaural unmasking, as demonstrated for the listener who underwent hearing-preservation surgery. This test of binaural audiovisual speech perception in noise could serve as a diagnostic tool to identify CI candidates who are most likely to receive

  11. Progress on the occulter experiment at Princeton

    Science.gov (United States)

    Cady, Eric; Balasubramanian, Kunjithapatham; Carr, Michael; Dickie, Matthew; Echternach, Pierre; Groff, Tyler; Kasdin, Jeremy; Laftchiev, Christian; McElwain, Michael; Sirbu, Dan; Vanderbei, Robert; White, Victor

    2009-08-01

    An occulter is used in conjunction with a separate telescope to suppress the light of a distant star. To demonstrate the performance of this system, we are building an occulter experiment in the laboratory at Princeton. This experiment will use an etched silicon mask as the occulter, with some modifications to try to improve the performance. The occulter is illuminated by a diverging laser beam to reduce the aberrations from the optics before the occulter. We present the progress of this experiment and expectations for future work.

  12. Radioimmune localization of occult carcinoma

    International Nuclear Information System (INIS)

    Duda, R.B.; Zimmer, A.M.; Rosen, S.T.; Gilyon, K.A.; Webber, D.; Spies, S.; Spies, W.; Merchant, B.

    1990-01-01

    Patients with a rising serum carcinoembryonic antigen level and no clinical or roentgenographic evidence of recurrent or metastatic cancer present a treatment dilemma. Eleven such patients, 10 with a previously treated colorectal carcinoma and 1 with a previously treated breast carcinoma, received an injection of the anticarcinoembryonic antigen monoclonal antibody ZCE-025 labeled with the radioisotope indium 111. Nuclear scintigraphy was performed on days 3 and 5 through 7 to detect potential sites of tumor recurrence. The monoclonal antibody scan accurately predicted the presence or absence of occult malignancy in 7 (64%) patients. Second-look laparotomy confirmed the monoclonal antibody scan results in the patients with colorectal cancer, and magnetic resonance imaging confirmed metastatic breast cancer. This study demonstrates that In-ZCE-025 can localize occult carcinoma and may assist the surgeon in facilitating the operative exploration. In-ZCE-025 assisted in the initiation of adjuvant therapy for the patient with breast cancer

  13. OCCULT POWER AND AFRICA'S SOCIO-ECONOMIC PROBLEMS ...

    African Journals Online (AJOL)

    Dr Ike

    people believe in the existence of occult powers and this belief affects their ... make use of occult powers to solve their problems. For example, ... existence and influence of paranormal and occult powers, argues that ..... and friends.

  14. Occultations for probing atmosphere and climate

    CERN Document Server

    Foelsche, Ulrich; Steiner, Andrea

    2004-01-01

    Use of occultation methodology for observing the Earth's atmosphere and climate has become so broad as to comprise solar, lunar, stellar, navigation and satellite­ crosslink occultation methods. The atmospheric parameters obtained extend from the fundamental variables temperature, density, pressure, water vapor, and ozone via a multitude of trace gas species to particulate species such as aerosols and cloud liquid water. Ionospheric electron density is sensed as well. The methods all share the key properties of self-calibration, high accuracy and vertical resolution, global coverage, and (if using radio signals) all-weather capability. Occultation data are thus of high value in a wide range of fields including climate monitoring and research, atmospheric physics and chemistry, operational meteorology, and other fields such as space weather and planetary science. This wide area of variants and uses of the occultation method has led to a diversi­ fication of the occultation-related scientific community into a...

  15. Sociology of religion and the occult revival

    Directory of Open Access Journals (Sweden)

    Lennart Ejerfeldt

    1975-01-01

    Full Text Available The "new" that makes the cults of the occult revival to "new religions" of the Western world, is their recently increased social significance. Historically most of modern occultism is anything but new. From the research and theorizing about the occult revival we have picked up some main themes. The first is the social diffusion of the new occultism. In this field, we find some studies of superstition, especially astrology. These illuminate the differences in social connotation between the consumers of superstition and the followers of institutional religion. Secondly the study of the occult revival has made valuable contributions to the conceptualizing of "cult" and the cultic phenomenon. Thirdly, we will look upon the connection between the occult revival and the counter-culture. The problem of the rise of cults as a symptom of socio-cultural change will be briefly discussed with reference to Bell's thesis of "the disjuntion of culture and social structure". Lastly, we proffer some reflections on the occult revival and the new spiritual trends in the churches, which so sharply contrast with the theology and churchmanship of the sixties.

  16. Reflective Occultation Mask for Evaluation of Occulter Designs for Planet Finding

    Science.gov (United States)

    Hagopian, John; Lyon, Richard; Shiri, Shahram; Roman, Patrick

    2011-01-01

    Advanced formation flying occulter designs utilize a large occulter mask flying in formation with an imaging telescope to block and null starlight to allow imaging of faint planets in exosolar systems. A paper describes the utilization of subscale reflective occultation masks to evaluate formation flying occulter designs. The use of a reflective mask allows mounting of the occulter by conventional means and simplifies the test configuration. The innovation alters the test set-up to allow mounting of the mask using standard techniques to eliminate the problems associated with a standard configuration. The modified configuration uses a reflective set-up whereby the star simulator reflects off of a reflective occulting mask and into an evaluation telescope. Since the mask is sized to capture all rays required for the imaging test, it can be mounted directly to a supporting fixture without interfering with the beam. Functionally, the reflective occultation mask reflects light from the star simulator instead of transmitting it, with a highly absorptive carbon nanotube layer simulating the occulter blocking mask. A subscale telescope images the star source and companion dim source that represents a planet. The primary advantage of this is that the occulter can be mounted conventionally instead of using diffractive wires or magnetic levitation.

  17. MR imaging of occult fractures of the knee

    International Nuclear Information System (INIS)

    Mink, J.H.; Deutsch, A.L.

    1988-01-01

    The authors encountered 65 radiographically occult fractures that they classified into five types. Bone bruises were a result of direct trauma or were associated with ligamentous injury. They were characterized by geographic foci of decreased signal on short repetition time (TR), short echo time (TE) sequences. Stress fractures were linear or globular foci of low signal on short TR, short TE sequences. Osteochondral fractures were displaced or impacted types; the latter were often associated with an anterior cruciate ligament tear. Tibial fractures were minimally displaced, vertically oriented fractures extending into the plateaus. Femoral fractures were Y-shaped, extending across the supracondylar region

  18. McDonald's and the Occult.

    Science.gov (United States)

    Singer, Barry

    1979-01-01

    Discusses "occult" and "paranormal" literature which is often mistaken for nonfiction. Suggests that most publishers are unwilling to publish scientific perspectives on the paranormal because such writings would be unmarketable. Journal availability: see SO 507 190. (KC)

  19. Optical performance of the New Worlds Occulter

    Science.gov (United States)

    Arenberg, Jonathan W.; Lo, Amy S.; Glassman, Tiffany M.; Cash, Webster

    2007-04-01

    The New Worlds Observer (NWO) is a multiple spacecraft mission that is capable of detecting and characterizing extra-solar planets and planetary systems. NWO consists of an external occulter and a generic space telescope, flying in tandem. The external occulter has specific requirements on its shape and size, while the telescope needs no special modification beyond that required to do high-quality astrophysical observations. The occulter is a petal-shaped, opaque screen that creates a high-suppression shadow large enough to accommodate the telescope. This article reports on the optical performance of the novel New Worlds occulter design. It also introduces two new aspects of its optical performance which enhance the detectability of extra-solar planets. We also include a brief discussion of the buildability and the tolerances of the occulter. It is also shown that an occulter design can be found for any set of science requirements. We show that NWO is a viable mission concept for the study of extra-solar planets. To cite this article: J.W. Arenberg et al., C. R. Physique 8 (2007).

  20. Early pre-eclampsia unmasks underlying IgA nephropathy

    Directory of Open Access Journals (Sweden)

    Mona Singh

    2010-12-01

    Full Text Available Mona Singh, Akhenaton Pappoe, Burl R DonDivision of Nephrology, University of California Davis Medical Center, Sacramento, CA, USAAbstract: Pre-eclampsia is the most ominous complication of pregnancy, and primary glomerular diseases can mimic pre-eclampsia in presentation. A patient presented at 21 weeks gestation with signs and symptoms of both pre-eclampsia and primary glomerular nephropathy. A critical clinical decision whether to continue or terminate the pregnancy was dependent on results of a renal biopsy. The biopsy noted the presence of both pre-eclampsia and immunoglobulin A (IgA nephropathy. Thus, the onset of pre-eclampsia unmasked the presence of unrecognized IgA nephropathy, and the IgA nephropathy was a risk factor for this patient developing pre-eclampsia. The results of a renal biopsy are key in distinguishing pre-eclampsia from other kidney diseases and instituting appropriate clinical management.Keywords: proteinuria, IgA nephropathy, renal biopsy, pre-eclampsia

  1. Oligometastasis as a predictor for occult disease.

    Science.gov (United States)

    Kendal, Wayne S

    2014-05-01

    Oligometastasis can be defined as a state of limited metastases that is potentially amenable to ablative local therapy; the success of such therapy depends on whether or not additional occult metastases exist. A model is presented here to predict occult metastases given detectable oligometastases. Predictions were based on Bayes' theorem, in conjunction with descriptions of the statistical distributions for the sizes and numbers of hematogenous metastases. The background probability for occult metastases in individuals with oligometastases increased markedly with relatively minor increases in metastatic potential. With each additional metastasis detected the chance of further occult metastases increased. These latter increases were incremental and proportionately smaller with the more metastatic tumors. Long disease free intervals had a major effect to decrease in the probability of further occult disease. Demonstration of oligometastases depends heavily upon the sensitivity of radiological imaging techniques, where the proportion of detectable metastases relates to the position of the distribution of metastasis growth times with respect to the detection threshold. Given the limitations of radiological methods, and the possibility that the oligometastases detected may be the only disease, an aggressive approach appears indicated. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Boundary diffraction wave integrals for diffraction modeling of external occulters

    OpenAIRE

    Cady, E.

    2012-01-01

    An occulter is a large diffracting screen which may be flown in conjunction with a telescope to image extrasolar planets. The edge is shaped to minimize the diffracted light in a region beyond the occulter, and a telescope may be placed in this dark shadow to view an extrasolar system with the starlight removed. Errors in position, orientation, and shape of the occulter will diffract additional light into this region, and a challenge of modeling an occulter system is to accurately and quickly...

  3. Strong scintillations during atmospheric occultations Theoretical intensity spectra. [radio scattering during spacecraft occultations by planetary atmospheres

    Science.gov (United States)

    Hinson, D. P.

    1986-01-01

    Each of the two Voyager spacecraft launched in 1977 has completed a reconnaissance of the Jovian and Saturnian systems. In connection with occultation experiments, strong scintillations were observed. Further theoretical work is required before these scintillations can be interpreted. The present study is, therefore, concerned with the derivation of a theory for strong scattering during atmospheric occultation experiments, taking into account as fundamental quantity of interest the spatial spectrum (or spectral density) of intensity fluctuations. Attention is given to a theory for intensity spectra, and numerical calculations. The new formula derived for Phi-i accounts for strong scattering of electromagnetic waves during atmospheric occultations.

  4. First results from stellar occultations in the "GAIA era"

    Science.gov (United States)

    Benedetti-Rossi, G.; Vieira-Martins, R.; Sicardy, B.

    2017-09-01

    Stellar occultation is a powerful technique to study distant solar system bodies. It allows high angular resolution of the occulting body from the analysis of a light curve acquired with high temporal resolution with uncertainties comparable as probes. In the "GAIA era", stellar occultations is now able to obtain even more impressive results such as the presence of atmosphere, rings and topographic features.

  5. Occult spondyloarthritis in inflammatory bowel disease.

    Science.gov (United States)

    Bandinelli, Francesca; Manetti, Mirko; Ibba-Manneschi, Lidia

    2016-02-01

    Spondyloarthritis (SpA) is a frequent extra-intestinal manifestation in patients with inflammatory bowel disease (IBD), although its real diffusion is commonly considered underestimated. Abnormalities in the microbioma and genetic predisposition have been implicated in the link between bowel and joint inflammation. Otherwise, up to date, pathogenetic mechanisms are still largely unknown and the exact influence of the bowel activity on rheumatic manifestations is not clearly explained. Due to evidence-based results of clinical studies, the interest on clinically asymptomatic SpA in IBD patients increased in the last few years. Actually, occult enthesitis and sacroiliitis are discovered in high percentages of IBD patients by different imaging techniques, mainly enthesis ultrasound (US) and sacroiliac joint X-ray examinations. Several diagnostic approaches and biomarkers have been proposed in an attempt to correctly classify and diagnose clinically occult joint manifestations and to define clusters of risk for patient screening, although definitive results are still lacking. The correct recognition of occult SpA in IBD requires an integrated multidisciplinary approach in order to identify common diagnostic and therapeutic strategies. The use of inexpensive and rapid imaging techniques, such as US and X-ray, should be routinely included in daily clinical practice and trials to correctly evaluate occult SpA, thus preventing future disability and worsening of quality of life in IBD patients.

  6. Contribution of low- and high-frequency bands to binaural unmasking in hearing-impaired listeners

    DEFF Research Database (Denmark)

    Locsei, Gusztav; Dau, Torsten; Santurette, Sébastien

    2017-01-01

    This study investigated the contribution of interaural timing differences (ITDs) in different frequency regions to binaural unmasking (BU) of speech. Speech reception thresholds (SRTs) and binaural intelligibility level differences (BILDs) were measured in two-talker babble in 6 young normal-hear...

  7. Occult hepatitis B infection: an evolutionary scenario

    Directory of Open Access Journals (Sweden)

    Lukashov Vladimir V

    2008-12-01

    Full Text Available Abstract Background Occult or latent hepatitis B virus (HBV infection is defined as infection with detectable HBV DNA and undetectable surface antigen (HBsAg in patients' blood. The cause of an overt HBV infection becoming an occult one is unknown. To gain insight into the mechanism of the development of occult infection, we compared the full-length HBV genome from a blood donor carrying an occult infection (d4 with global genotype D genomes. Results The phylogenetic analysis of polymerase, core and X protein sequences did not distinguish d4 from other genotype D strains. Yet, d4 surface protein formed the evolutionary outgroup relative to all other genotype D strains. Its evolutionary branch was the only one where accumulation of substitutions suggests positive selection (dN/dS = 1.3787. Many of these substitutiions accumulated specifically in regions encoding the core/surface protein interface, as revealed in a 3D-modeled protein complex. We identified a novel RNA splicing event (deleting nucleotides 2986-202 that abolishes surface protein gene expression without affecting polymerase, core and X-protein related functions. Genotype D strains differ in their ability to perform this 2986-202 splicing. Strains prone to 2986-202 splicing constitute a separate clade in a phylogenetic tree of genotype D HBVs. A single substitution (G173T that is associated with clade membership alters the local RNA secondary structure and is proposed to affect splicing efficiency at the 202 acceptor site. Conclusion We propose an evolutionary scenario for occult HBV infection, in which 2986-202 splicing generates intracellular virus particles devoid of surface protein, which subsequently accumulates mutations due to relaxation of coding constraints. Such viruses are deficient of autonomous propagation and cannot leave the host cell until it is lysed.

  8. Radiographically Occult and Subtle Fractures: A Pictorial Review

    International Nuclear Information System (INIS)

    Jarraya, M.; Hayashi, D.; Roemer, F.W.; Crema, M.D.; Conlin, J.; Marra, M.D.; Guermazi, A.; Roemer, F.W.; Crema, M.D.; Diaz, L.; Conlin, J.; Jomaah, N.

    2013-01-01

    Radiographically occult and subtle fractures are a diagnostic challenge. They may be divided into (1) high energy trauma fracture, (2) fatigue fracture from cyclical and sustained mechanical stress, and (3) insufficiency fracture occurring in weakened bone (e.g., in osteoporosis and post radiotherapy). Independently of the cause, the initial radiographic examination can be negative either because the findings seem normal or are too subtle. Early detection of these fractures is crucial to explain the patients symptoms and prevent further complications. Advanced imaging tools such as computed tomography, magnetic resonance imaging, and scintigraphy are highly valuable in this context. Our aim is to raise the awareness of radiologists and clinicians in these cases by presenting illustrative cases and a discussion of the relevant literature.

  9. Occult diaphragmatic injuries caused by stab wounds.

    Science.gov (United States)

    Leppäniemi, Ari; Haapiainen, Reijo

    2003-10-01

    Missed diaphragmatic perforation caused by penetrating trauma can lead to subsequent strangulation of a hollow viscus, which has prompted the use of invasive diagnostic procedures to exclude occult diaphragmatic injuries in asymptomatic, high-risk patients. The objective of this study was to determine the incidence of occult diaphragmatic injuries caused by stab wounds of the lower chest and upper abdomen, and to examine the natural history and consequences of missed diaphragmatic injuries. On the basis of patient data from two previous randomized studies from our institution, a retrospective analysis was performed on 97 patients treated for anterior stab wounds located between the nipple line, the umbilical level, and the posterior axillary lines not having indications for immediate surgical exploration. The patients were divided into two groups on the basis of their initial randomized management (open or laparoscopic exploration vs. expectant observation). In the exploration group (n = 47), four diaphragmatic injuries (9%) were detected (three left-sided and one right-sided). Excluding patients with associated injuries requiring surgical repair, the incidence of occult diaphragmatic injuries was 3 of 43 (7%). In the observation group (n = 50), there were two patients (4%) with delayed presentation of missed left-sided diaphragmatic injury 2 and 23 months later, respectively. Both injuries resulted from stab wounds of the left flank and presented with herniation of the stomach or small bowel and colon. The overall incidence of occult diaphragmatic injuries in left-sided thoracoabdominal stab wounds was 4 of 24 (17%), and was much lower after stab wounds of left epigastrium (0%), right lower chest (0%), and right epigastrium (4%). In asymptomatic patients with anterior or flank stab wounds of the lower chest or upper abdominal area, the risk of an occult diaphragmatic injury is approximately 7% which, if undetected, is associated with a high risk of subsequent

  10. Occult fractures of the knee: tomographic evaluation

    International Nuclear Information System (INIS)

    Apple, J.S.; Martinez, S.; Allen, N.B.; Caldwell, D.S.; Rice, J.R.

    1983-01-01

    Seven adults with painful effusions of the knee were examined for occult fractures using pluridirectional tomograph in the coronal and lateral planes. Six patients (ages 50 to 82 years) were osteopenic and gave histories ranging from none to mild trauma; one 26-year-old man was not osteopenic and had severe trauma. In all cases, routine radiographs were interpreted as negative, but tomography demonstrated a fracture. Five fractures were subchondral. Bone scans in 2 patients were positive. The authors conclude that osteopenic patients with a painful effusion of the knee should be considered to have an occult fracture. While bone scans may be helpful, tomography is recommended as the procedure of choice to define the location and extent of the fracture

  11. Paraneoplastic retinopathy associated with occult bladder cancer

    DEFF Research Database (Denmark)

    Nivean, M; Muttuvelu, Danson V; Afzelius, Pia Maria Tullia

    2016-01-01

    (ERG), serology including serum antibodies for CAR, and positron emission tomography-computed tomography (PET-CT) scan. The patient was diagnosed with bladder carcinoma revealed by PET-CT. Timely recognition of this entity may be crucial for an increased patient survival thus adult onset progressive...... photoreceptor dysfunction, confirmed by ERG, should alert to a possible remote effect of known or occult malignancy. In the latter, PET-CT may be exploited as a powerful diagnostic tool....

  12. Results from occultations by minor planets

    International Nuclear Information System (INIS)

    Taylor, G.E.

    1982-01-01

    Since the minor planets are believed to consist of primordial matter dating from the time of the formation of the solar system there is great interest in determining their composition. It is therefore necessary to calculate their densities, for which we need accurate masses and sizes. On the rare occasions when a minor planet occults a star, timed observations of the event from a number of observing sites enable an accurate size of the minor planet to be determined. (Auth.)

  13. ASTEROID SIZING BY RADIOGALAXY OCCULTATION AT 5 GHZ

    Energy Technology Data Exchange (ETDEWEB)

    Lehtinen, K.; Muinonen, K.; Poutanen, M. [Finnish Geospatial Research Institute FGI, Geodeetinrinne 2, FI-02430 Masala (Finland); Bach, U. [Max-Planck-Institut für Radioastronomie, Radioobservatorium Effelsberg, Max-Planck-Str. 28, D-53902 Bad Münstereifel-Effelsberg (Germany); Petrov, L., E-mail: kimmo.lehtinen@nls.fi [Astrogeo Center, Falls Church, VA 22043 (United States)

    2016-05-10

    Stellar occultations by asteroids observed at visual wavelengths have been an important tool for studying the size and shape of asteroids and for revising the orbital parameters of asteroids. At radio frequencies, a shadow of an asteroid on the Earth is dominated by diffraction effects. Here, we show, for the first time, that a single observation of an occultation of a compact radio source at a frequency of 5 GHz can be used to derive the effective size of the occulting object and to derive the distance between the observer and the center of the occultation path on the Earth. The derived diameter of the occulting object, asteroid (115) Thyra, is 75 ± 6 km. The observed occultation profile shows features that cannot be explained by diffraction of a single asteroid.

  14. OCCULTISM AND MEDIUMSHIP IN FERNANDO PESSOA

    Directory of Open Access Journals (Sweden)

    Alisson Diêgo Dias de Medeiros

    2016-03-01

    Full Text Available This work is the result of a research on the influence that the occultism had on the work of the Portuguese poet Fernando Pessoa. To delimitate the study, we selected papers of Fernando Pessoa, which  suggested that the poet considered himself medium, and hence influenced his work, building his depersonalization. This work presents, thus, as main objectiveto analyze personal papers of Fernando Pessoa, whose outstanding characteristic is the presence of occultism and the supposed mediumship defended by him in response to non-literary and heteronymic manifestations. To this end, I focused on specific objectives, which are: a to study the speech of Fernando Pessoa on his supposed mediumship / occultism b to analyze specific texts that are, for the poet, mediumistic manifestations c to study excerpts from a set of personal letters in which Fernando Pessoa suggested being a medium. It is true that this dissertation will address many discussions already made by scholars and specialists in Fernando Pessoa, but we consider the possibility to deepen issues and contribute to the critical fortune of the poet.

  15. Ultrasound detection of nonpalpable mammographically occult malignancy

    International Nuclear Information System (INIS)

    Simpson, W.L.; Hermann, G.; Rausch, D.R.; Sherman, J.; Feig, S.A.; Bleiweiss, I.J.; Jaffer, S.

    2008-01-01

    To evaluate the prevalence of occult malignancy with screening breast ultrasound. All ultrasound-guided core needle breast biopsies performed between January 1, 1999, and June 30, 2001, were retrospectively reviewed. Lesions were identified during screening breast ultrasound in high-risk women with no mammographic or palpable abnormality in either breast, a unilateral mammographic or palpable abnormality in the contralateral breast, or a unilateral mammographic or palpable abnormality in a different quadrant of the same breast. All ultrasound-detected lesions were histologically verified. Six hundred and fifty-two women with a mean age of 49 years underwent 698 biopsies during the study period. Three hundred and forty-nine of these lesions were detected at screening breast ultrasound. Out of 349, 11 (3.2%) had a mammographically and clinically occult malignancy. Nine cancers were found in women with no mammographic or palpable abnormality. Two cancers were found in the same breast as the mammographic or palpable abnormality. None were found in the breast contralateral to a palpable or mammographic abnormality. Screening breast ultrasound of high-risk women has a similar detection rate for occult carcinoma as screening mammography, but has a low positive predictive value in cases where biopsy is performed. (author)

  16. OCCULT-ORSER complete conversational user-language translator

    Science.gov (United States)

    Ramapriyan, H. K.; Young, K.

    1981-01-01

    Translator program (OCCULT) assists non-computer-oriented users in setting up and submitting jobs for complex ORSER system. ORSER is collection of image processing programs for analyzing remotely sensed data. OCCULT is designed for those who would like to use ORSER but cannot justify acquiring and maintaining necessary proficiency in Remote Job Entry Language, Job Control Language, and control-card formats. OCCULT is written in FORTRAN IV and OS Assembler for interactive execution.

  17. Immune reconstitution inflammatory syndrome unmasking erythema nodosum leprosum: A rare case report

    Directory of Open Access Journals (Sweden)

    Geeta Kiran Arakkal

    2015-01-01

    Full Text Available Immune reconstitution inflammatory syndrome (IRIS occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients. IRIS triggers both opportunistic and non-opportunistic infections. We report a case of IRIS in a patient with HIV, presenting as erythema nodosum leprosum (ENL, which led to unmasking of lepromatous leprosy following anti-retroviral therapy (ART.

  18. Masked and unmasked priming effects as a function of semantic relatedness and associative strength.

    Science.gov (United States)

    Sánchez-Casas, Rosa; Ferré, Pilar; Demestre, Josep; García-Chico, Teófilo; García-Albea, José E

    2012-11-01

    The study presented in this paper aimed to investigate the pattern of semantic priming effects, under masked and unmasked conditions, in the lexical decision task, manipulating type of semantic relation and associative strength. Three different kinds of word relations were examined in two experiments: only-semantically related words [e.g., codo (elbow)-rodilla (knee)] and semantic/associative related words with strong [e.g., mesa (table)-silla (chair) and weak association strength [e.g., sapo (toad)-rana (frog)]. In Experiment 1 a masked priming procedure was used with a prime duration of 56 ms, and in Experiment 2, the prime was presented unmasked for 150 ms. The results showed that there were masked priming effects with strong associates, but no evidence of these effects was found with weak associates or only-semantic related word pairs. When the prime was presented unmasked, the three types of relations produced significant priming effects and they were not influenced by association strength.

  19. Masked and unmasked error-related potentials during continuous control and feedback

    Science.gov (United States)

    Lopes Dias, Catarina; Sburlea, Andreea I.; Müller-Putz, Gernot R.

    2018-06-01

    The detection of error-related potentials (ErrPs) in tasks with discrete feedback is well established in the brain–computer interface (BCI) field. However, the decoding of ErrPs in tasks with continuous feedback is still in its early stages. Objective. We developed a task in which subjects have continuous control of a cursor’s position by means of a joystick. The cursor’s position was shown to the participants in two different modalities of continuous feedback: normal and jittered. The jittered feedback was created to mimic the instability that could exist if participants controlled the trajectory directly with brain signals. Approach. This paper studies the electroencephalographic (EEG)—measurable signatures caused by a loss of control over the cursor’s trajectory, causing a target miss. Main results. In both feedback modalities, time-locked potentials revealed the typical frontal-central components of error-related potentials. Errors occurring during the jittered feedback (masked errors) were delayed in comparison to errors occurring during normal feedback (unmasked errors). Masked errors displayed lower peak amplitudes than unmasked errors. Time-locked classification analysis allowed a good distinction between correct and error classes (average Cohen-, average TPR  =  81.8% and average TNR  =  96.4%). Time-locked classification analysis between masked error and unmasked error classes revealed results at chance level (average Cohen-, average TPR  =  60.9% and average TNR  =  58.3%). Afterwards, we performed asynchronous detection of ErrPs, combining both masked and unmasked trials. The asynchronous detection of ErrPs in a simulated online scenario resulted in an average TNR of 84.0% and in an average TPR of 64.9%. Significance. The time-locked classification results suggest that the masked and unmasked errors were indistinguishable in terms of classification. The asynchronous classification results suggest that the

  20. Prevalence of occult inflammatory bowel disease in ankylosing spondylitis.

    Science.gov (United States)

    Costello, P B; Alea, J A; Kennedy, A C; McCluskey, R T; Green, F A

    1980-10-01

    Fifty-five patients with ankylosing spondylitis and 16 control patients matched for sex and age were examined for evidence of occult inflammatory bowel disease. In all patients evaluation included history and physical examination, barium enema, sigmoidoscopy, and rectal biopsy. The results of this study suggest that there is no increased prevalence of occult inflammatory bowel disease in patients with ankylosing spondylitis.

  1. 21 CFR 864.6550 - Occult blood test.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Occult blood test. 864.6550 Section 864.6550 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Manual Hematology Devices § 864.6550 Occult blood test. (a...

  2. Molecular and serological detection of occult hepatitis B virus ...

    African Journals Online (AJOL)

    Background: Occult hepatitis B infections are becoming a major global threat, but the available data on its prevalence in various parts of the world are often divergent. Objective: This study aimed to detect occult hepatitis B virus in hepatitis B surface antigen-negative serum using anti-HBc as a marker of previous infection.

  3. Occult Hepatitis B Virus in Gezira State Sudan | Gasmelseed ...

    African Journals Online (AJOL)

    Background: Occult hepatitis B infection (OBI) is simply defined as serologically undetectable hepatitis B surface antigen (HBsAg-ve), despite the presence of circulating HBV DNA. Objective: The aim of this study was to determine the prevalence of occult HBV among Screened HBsAg subjects in Gezira State, Sudan.

  4. Radio Occultation Bending Angle Anomalies During Tropical Cyclones

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Neubert, Torsten; Syndergaard, Stig

    signature in radio occultation profiles in the tropical tropopause layer. Using tropical cyclone best track database and data from the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC), we show that the bending angle anomaly of a GPS radio occultation signal is typically larger...

  5. Esophageal Metastasis From Occult Lung Cancer

    Directory of Open Access Journals (Sweden)

    Po-Kuei Hsu

    2010-06-01

    Full Text Available A 66-year-old man with dysphagia was found to have a poorly differentiated esophageal carcinoma by incision biopsy. Following esophagectomy, reconstruction with a gastric tube was performed. Pathological examination and immunohisto-chemistry showed infiltration of adenocarcinoma cells with positive thyroid transcription factor 1-staining in the submucosal layer, which indicated metastatic esophageal carcinoma. Although no pulmonary lesion could be visualized by imaging or bronchoscopy, pulmonary origin was highly suspected as a result of positive thyroid transcription factor 1-staining. To the best of our knowledge, this is the first reported case of metastatic esophageal carcinoma from occult lung cancer (AJCC TNM stage TX.

  6. Neurogenic bladder from occult herpes zoster.

    Science.gov (United States)

    Rothrock, J F; Walicke, P A; Swenson, M R

    1986-11-01

    Active infection with herpes zoster may cause acute urinary retention, especially when it involves sacral dermatomes. Although frank retention usually develops days to weeks after eruption of the typical rash, bladder incompetence infrequently develops first, raising concern over other, more ominous etiologies. In the case presented, rash appearance was delayed until six weeks after the initial onset of urinary retention, a much longer interval than previously reported. Occult herpes zoster infection should be considered in patients presenting with an acute neurogenic bladder of obscure cause.

  7. Deadaption and Readaptation with Lactose, But No Cross-Adaptation to Lactulose: A Case of Occult Colonic Bacterial Adaptation

    Directory of Open Access Journals (Sweden)

    Andrew Szilagyi

    2004-01-01

    Full Text Available The standard 3 h breath hydrogen (3hBH2 test distinguishes lactose maldigesters from lactose digesters. However, multiple factors impact on BH2 and care is needed to exclude a priori variables. When these factors are controlled, a negative BH2 test implies lactase persistent status or lactase nonpersistent status with colonic adaptation. A case of a Sicilian man who tested negative (lactase persistent status confirmed on an initial 50 g lactose challenge is described. It was observed that he consumed 28.1 g lactose/day before testing. He subsequently underwent five additional challenge tests in the course of the next 10 months. In four tests the dose intake of lactose was varied upon instruction, and in the fifth test a 30 g lactulose challenge was carried out. It was demonstrated that on radically decreasing lactose intake, a full lactase nonpersistent status was unmasked. Output of 3hBH2 varied inversely with daily lactose intake. Finally, at a time when he was readapted to lactose, there was no discernible adaptation to lactulose challenge. It was concluded that 'occult' colonically adapted subjects may contribute to negative BH2 tests. There is a relationship between variation in lactose intake and the results of BH2 testing. Finally, there was no cross-adaptation to lactulose challenge when lactose was used as the adapting sugar.

  8. Unmasking the health problems faced by the police personnel

    Directory of Open Access Journals (Sweden)

    G.Jahnavi

    2012-11-01

    Full Text Available Aim: To assess the health problems of the police personnel under Vijayawada police commisionerate 2. To make the health check ups regular and 3. To make the physical fitness programme mandatory for them.Study design: cross sectional study Methodology: Health check up was done for 617 police personnel from 12.11.09 to 4.12.09. In the morning hours, a group of junior doctors, paramedical staff and technicians visited the police dispensary to do the general check up, take blood samples and ECG. The following afternoon a group of specialists visited to check the same patients along with their reports to make the final diagnosis. Results: Out of 617 police personnel 259 (42% were overweight/obese, lack of physical activity was found in 397 (64% of them, alcohol consumption was present in 148 (24% and smoking in 136 (22% of the police personnel. Diabetes was diagnosed in 229 (37% and hypertension in 203 (33%. Anemia was detected in 154 (25%, visual abnormalities in 59 (10%, lipid abnormalities in 185 (30%, liver function test abnormalities in 31 (5%, ECG abnormalities in 25 (4%, renal function abnormalities in 6 (1%. Conclusion: A Physical fitness Schedule along with Stress alleviation techniques to be made mandatory for the police personnel to keep them physically and mentally fit, to perform critical job functions, to alleviate stress, and to improve their quality of life. Routine health checkups should be done to detect lurking dangers.

  9. Lunar occultation observations of the Crab Nebula

    International Nuclear Information System (INIS)

    Maloney, F.P.

    1977-01-01

    Three lunar of occultations of the Crab Nebula were observed, two at 114 MHz and one at 26.3 MHz, during the 1974 series of events. The higher frequency observations were deconvolved of diffraction effects to yield four strip integrated brightness profiles of the Nebula, with an effective resolution of 30 arc-seconds. These four profiles were Fourier inverted and cleaned of sidelobe structure to synthesize a two-dimensional map of the Nebula. At 114 MHz, the Nebula is composed of a broad envelope of emission which contains several smaller sources. The attenuation of the low radio frequency radiation by the thermal hydrogen in the filaments is considered as a possible mechanism to explain these new data. The 26.3 MHz observations indicate the presence of a bright, localized source containing greater than 80% of the flux of the Nebula. The position of the source is confined by the data to a narrow strip centered at the pulsar position. Both sets of data are compared with past occultation observations

  10. Current management of occult bacteremia in infants

    Directory of Open Access Journals (Sweden)

    Eduardo Mekitarian Filho

    2015-11-01

    Full Text Available Objectives: To summarize the main clinical entities associated with fever without source (FWS in infants, as well as the clinical management of children with occult bacteremia, emphasizing laboratory tests and empirical antibiotics. Sources: A non-systematic review was conducted in the following databases – PubMed, EMBASE, and SciELO, between 2006 and 2015. Summary of the findings: The prevalence of occult bacteremia has been decreasing dramatically in the past few years, due to conjugated vaccination against Streptococcus pneumoniae and Neisseria meningitidis. Additionally, fewer requests for complete blood count and blood cultures have been made for children older than 3 months presenting with FWS. Urinary tract infection is the most prevalent bacterial infection in children with FWS. Some known algorithms, such as Boston and Rochester, can guide the initial risk stratification for occult bacteremia in febrile infants younger than 3 months. Conclusions: There is no single algorithm to estimate the risk of occult bacteremia in febrile infants, but pediatricians should strongly consider outpatient management in fully vaccinated infants older than 3 months with FWS and good general status. Updated data about the incidence of occult bacteremia in this environment after conjugated vaccination are needed. Resumo: Objetivos: Listar as principais entidades clínicas associadas a quadros de febre sem sinais localizatórios (FSSL em lactentes, bem como o manejo dos casos de bacteremia oculta com ênfase na avaliação laboratorial e na antibioticoterapia empírica. Fonte dos dados: Foi realizada revisão não sistemática da literatura nas bases de dados PubMed, EMBASE e Scielo no período de 2006 a 2015. Síntese dos dados: A ocorrência de bacteremia oculta vem diminuindo sensivelmente em lactentes com FSSL, principalmente devido à introdução da vacinação conjugada contra Streptococcus pneumoniae e Neisseria meningitidis nos últimos anos

  11. Fecal Occult Blood Test and Gastrointestinal Parasitic Infection

    Directory of Open Access Journals (Sweden)

    Majed H. Wakid

    2010-01-01

    Full Text Available Stool specimens of 1238 workers in western region of Saudi Arabia were examined for infection with intestinal parasites and for fecal occult blood (FOB to investigate the possibility that enteroparasites correlate to occult intestinal bleeding. Direct smears and formal ether techniques were used for detection of diagnostic stages of intestinal parasites. A commercially available guaiac test was used to detect fecal occult blood. 47.01% of the workers were infected with intestinal parasites including eight helminthes species and eight protozoan species. The results provided no significant evidence (P-value=0.143 that intestinal parasitic infection is in association with positive guaiac FOB test.

  12. CT detection of occult pneumothorax in head trauma

    International Nuclear Information System (INIS)

    Tocino, I.M.; Miller, M.H.; Frederick, P.R.; Bahr, A.L.; Thomas, F.

    1984-01-01

    A prospective evaluation for occult pneumothorax was performed in 25 consecutive patients with serious head trauma by combining a limited chest CT examination with the emergency head CT examination. Of 21 pneuomothoraces present in 15 patients, 11 (52%) were found only by chest CT and were not identified clinically or by supine chest radiograph. Because of pending therapeutic measures, chest tubes were placed in nine of the 11 occult pneumothoraces, regardless of the volume. Chest CT proved itself as the most sensitive method for detection of occult pneumothorax, permitting early chest tube placement to prevent transition to a tension pneumothorax during subsequent mechanical ventilation or emergency surgery under general anesthesia

  13. CT detection of occult pneumothorax in head trauma

    Energy Technology Data Exchange (ETDEWEB)

    Tocino, I.M.; Miller, M.H.; Frederick, P.R.; Bahr, A.L.; Thomas, F.

    1984-11-01

    A prospective evaluation for occult pneumothorax was performed in 25 consecutive patients with serious head trauma by combining a limited chest CT examination with the emergency head CT examination. Of 21 pneuomothoraces present in 15 patients, 11 (52%) were found only by chest CT and were not identified clinically or by supine chest radiograph. Because of pending therapeutic measures, chest tubes were placed in nine of the 11 occult pneumothoraces, regardless of the volume. Chest CT proved itself as the most sensitive method for detection of occult pneumothorax, permitting early chest tube placement to prevent transition to a tension pneumothorax during subsequent mechanical ventilation or emergency surgery under general anesthesia.

  14. Profiling Saturn's rings by radio occultation

    International Nuclear Information System (INIS)

    Marouf, E.A.; Tyler, G.L.; Rosen, P.A.

    1986-01-01

    The development of reconstruction algorithms that correct for diffraction effects in radio occultation measurements is described. The reciprocal Fresnel transform relationship between the complex amplitude of the observed coherent signal and the complex microwave transmittance of the rings is derived using the Huygens-Fresnel formulation of the diffraction problem. The effects of the finite data segment width, the uncertainties in the Fresnel scale, systematic phase errors in the kernel of the inverse transform, reference oscillator instabilities, and random noise measurements on the resolution of the reconstructed transmittance are analyzed. Examples of reconstructed opacity profiles for some regions of Saturn's rings derived by applying the reconstruction theory to Voyager 1 at Saturn data are presented. 35 references

  15. Diagnosis of occult abdominal abscesses using radioisotopes

    International Nuclear Information System (INIS)

    Koch, B.; Schroth, H.J.; Wolf, N.; Wilhelm, H.; Universitaet des Saarlandes, Homburg/Saar

    1983-01-01

    Occult intraperitoneal abscesses are difficult to localize and dispose of. Therefore, a method of examination is needed that is specific, can be used at any time, is not expensive, and yields early results within 2-3 h. This seems possible with a new method of examination. sup(99m)Tc-Sn-colloid was used to label autologous polymorphonuclear leukocytes which, when reinjected, emigrate to the site of the suspected abscess. Standard scintigraphy localizes the labeled inflammatory cells. Scans were performed in 57 surgical patients with good results. 23 (40,4%) patients had true negative results; 28 (49,1%) scans represented intraperitoneal abscesses; 5 (8,8%) scans demonstrated true positive extraperitoneal inflammations. Only 1 (1,7%) scan was false positive. (orig.) [de

  16. Stress

    Science.gov (United States)

    ... can be life-saving. But chronic stress can cause both physical and mental harm. There are at least three different types of stress: Routine stress related to the pressures of work, family, and other daily responsibilities Stress brought about ...

  17. Atmospheric stability index using radio occultation refractivity profiles

    Indian Academy of Sciences (India)

    A new stability index based on atmospheric refractivity at ∼500 hPa level and surface measurements of temperature ... able at different heights rather than pressure levels. However ..... the radio occultation technique being a limb sound-.

  18. Characterization and evolution of distant planetary atmospheres using stellar occultations

    Science.gov (United States)

    Young, L. A.

    2008-09-01

    Ground-based or near-Earth (e.g., HST) stellar occultations of every atmosphere in our solar system has been observed: Venus, Mars, Jupiter, Saturn, Titan, Uranus, Neptune, Triton, and Pluto [1]. These observations probe the atmospheres at roughly 0.1 to 100 microbar. I will talk about three aspects of stellar occultations: one-dimensional vertical profiles of the atmosphere, two- or three-dimensional atmospheric states, and the time evolution of atmosphere. In all three, I will draw on recent observations, with an emphasis on Pluto. Occultations are particularly important for the study of Pluto's atmosphere, which is impossible to study with imaging, and extremely difficult to study with spectroscopy. It was discovered by stellar occultation in 1988 [2]. No subsequent Pluto occultations were observed until two events in 2002 [3]. Pluto is now crossing the galactic plane, and there have been several additional occultations observed since 2006. These include a high signal-to-noise observation from the Anglo Australian Observatory in 2006 [4] (Fig 1), densely spaced visible and infrared observations of Pluto's upper atmosphere from telescopes in the US and Mexico in March, 2007 [5] (Fig. 2), and a dualwavelength central flash observation from Mt. John in July, 2007 [6] (Fig 3). The flux from a star occulted by an atmosphere diminishes primarily due to the increase in refraction with depth in the atmosphere, defocusing the starlight, although absorption and tangential focusing can also contribute. Because the atmospheric density, to first order, follows an exponential, it is feasible to derive a characteristic pressure and temperature from isothermal fits to even low-quality occultation light curves. Higher quality light curves allow fits with more flexible models, or light curve inversions that derive temperatures limited by the resolution of the data. These allow the derivation of one-dimensional profiles of temperature and pressure vs. altitude, which are critical

  19. UARS Halogen Occultation Experiment (HALOE) Level 2 V001

    Data.gov (United States)

    National Aeronautics and Space Administration — The HALOE home page on the WWW is http://haloe.gats-inc.com/home/index.php The Halogen Occultation Experiment (HALOE) on NASA's Upper Atmosphere Research Satellite...

  20. Photoreceptor atrophy in acute zonal occult outer retinopathy

    DEFF Research Database (Denmark)

    Zibrandtsen, N.; Munch, I.C.; Klemp, K.

    2006-01-01

    Purpose: To assess retinal morphology in acute zonal occult outer retinopathy (AZOOR). Methods: Three patients with a normal ophthalmoscopic fundus appearance, a history of photopsia, and visual field loss compatible with AZOOR were examined using optical coherence tomography, automated perimetry...

  1. Binaural unmasking of multi-channel stimuli in bilateral cochlear implant users.

    Science.gov (United States)

    Van Deun, Lieselot; van Wieringen, Astrid; Francart, Tom; Büchner, Andreas; Lenarz, Thomas; Wouters, Jan

    2011-10-01

    Previous work suggests that bilateral cochlear implant users are sensitive to interaural cues if experimental speech processors are used to preserve accurate interaural information in the electrical stimulation pattern. Binaural unmasking occurs in adults and children when an interaural delay is applied to the envelope of a high-rate pulse train. Nevertheless, for speech perception, binaural unmasking benefits have not been demonstrated consistently, even with coordinated stimulation at both ears. The present study aimed at bridging the gap between basic psychophysical performance on binaural signal detection tasks on the one hand and binaural perception of speech in noise on the other hand. Therefore, binaural signal detection was expanded to multi-channel stimulation and biologically relevant interaural delays. A harmonic complex, consisting of three sinusoids (125, 250, and 375 Hz), was added to three 125-Hz-wide noise bands centered on the sinusoids. When an interaural delay of 700 μs was introduced, an average BMLD of 3 dB was established. Outcomes are promising in view of real-life benefits. Future research should investigate the generalization of the observed benefits for signal detection to speech perception in everyday listening situations and determine the importance of coordination of bilateral speech processors and accentuation of envelope cues.

  2. Europe's space camera unmasks a cosmic gamma-ray machine

    Science.gov (United States)

    1996-11-01

    brighter flashes when the electrons hit a phosphor screen. Since Hubble's launch in 1990, the Faint Object Camera has examined many different kinds of cosmic objects, from the moons of Jupiter to remote galaxies and quasars. When the space telescope's optics were corrected at the end of 1993 the Faint Object Camera immediately celebrated the event with the discovery of primeval helium in intergalactic gas. In their search for Pulsar 1055-52, the astronomers chose a near-ultraviolet filter to sharpen the Faint Object Camera's vision and reduce the adjacent star's huge advantage in intensity. In May 1996, the Hubble Space Telescope operators aimed at the spot which radio astronomers had indicated, as the source of the radio pulsations of Pulsar 1055-52. The neutron star appeared precisely in the centre of the field of view, and it was clearly separated from the glare of the adjacent star. At magnitude 24.9, Pulsar 1055-52 was comfortably within the power of the Faint Object Camera, which can see stars 20 times fainter still. "The Faint Object Camera is the instrument of choice for looking for neutron stars," says Giovanni Bignami, speaking on behalf of the Italian team. "Whenever it points to a judiciously selected neutron star it detects the corresponding visible or ultraviolet light. The Faint Object Camera has now identified three neutron stars in that way, including Pulsar 1055-52, and it has examined a few that were first detected by other instruments." Mysteries of the neutron stars The importance of the new result can be gauged by the tally of only eight neutron stars seen so far at optical wavelengths, compared with about 760 known from their radio pulsations, and about 21 seen emitting X-rays. Since the first pulsar was detected by radio astronomers in Cambridge, England, nearly 30 years ago, theorists have come to recognize neutron stars as fantastic objects. They are veritable cosmic laboratories in which Nature reveals the behaviour of matter under extreme stress

  3. Diagnostic strategy for occult hepatitis B virus infection

    Science.gov (United States)

    Ocana, Sara; Casas, Maria Luisa; Buhigas, Ingrid; Lledo, Jose Luis

    2011-01-01

    In 2008, the European Association for the study of the liver (EASL) defined occult hepatitis B virus infection (OBI) as the “presence of hepatitis B virus (HBV) DNA in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing hepatitis B surface antigen (HBsAg) negative by currently available assays”. Several aspects of occult HBV infection are still poorly understood, including the definition itself and a standardized approach for laboratory-based detection, which is the purpose of this review. The clinical significance of OBI has not yet been established; however, in terms of public health, the clinical importance arises from the risk of HBV transmission. Consequently, it is important to detect high-risk groups for occult HBV infection to prevent transmission. The main issue is, perhaps, to identify the target population for screening OBI. Viremia is very low or undetectable in occult HBV infection, even when the most sensitive methods are used, and the detection of the viral DNA reservoir in hepatocytes would provide the best evaluation of occult HBV prevalence in a defined set of patients. However, this diagnostic approach is obviously unsuitable: blood detection of occult hepatitis B requires assays of the highest sensitivity and specificity with a lower limit of detection < 10 IU/mL for HBV DNA and < 0.1 ng/mL for HBsAg. PMID:21472120

  4. Possible occultation by Pluto from US East Coast

    Science.gov (United States)

    Waagen, Elizabeth O.

    2012-06-01

    We have been asked to help disseminate the news of a possible occultation by Pluto visible to observers on the US East coast. Although the AAVSO does not ordinarily issue announcements of upcoming occultations, in this case the object is Pluto and the NASA New Horizons mission (http://www.nasa.gov/mission_pages/newhorizons/main/index.html) will be visiting Pluto in 2015. The information below has been supplied by Dr. Leslie Young (Southwest Research Institute), who is coordinating this observing campaign on Pluto. Dr. Young is also Deputy Project Scientist for the New Horizons mission. ALERT: Possible Pluto occultation Wednesday night (2012/06/14 03:28 UT) from US East coast. CONTACT: Leslie Young (layoung@boulder.swri.edu; work: 303-546-6057; skype: drpluto). Also see our planning pages in progress at http://wiki.boulder.swri.edu/mediawiki/index.php/2012-06-14_Pluto_occultation. Pluto's thin, nitrogen atmosphere is in vapor-pressure equilibrium with the surface ice, and changes seasonally. We've seen it double since 1988, and now we measure its pressure once or twice a year. The technique we use is stellar occultation, when a star passes behind Pluto's atmosphere. The atmosphere defocuses the starlight. By the timing of the fading of the star, we measure the pressure and temperature in Pluto's atmosphere at ~10 km resolution. MORE INFORMATION: See http://wiki.boulder.swri.edu/mediawiki/index.php/2012-06-14_Pluto_occultation.

  5. Unmasking cryptococcal meningitis immune reconstitution inflammatory syndrome in pregnancy induced by HIV antiretroviral therapy with postpartum paradoxical exacerbation

    Directory of Open Access Journals (Sweden)

    Reuben Kiggundu

    2014-07-01

    Full Text Available Cryptococcosis is the most common cause of meningitis in Africa due to the high burden of HIV. Immune reconstitution inflammatory syndrome (IRIS is a frequent and deadly complication of cryptococcal meningitis. We report a fatal case of cryptococcal-IRIS in a pregnant woman that began after starting antiretroviral therapy (unmasking IRIS and markedly worsened postpartum after delivery (paradoxical IRIS.

  6. Occult pneumomediastinum in blunt chest trauma: clinical significance.

    Science.gov (United States)

    Rezende-Neto, J B; Hoffmann, J; Al Mahroos, M; Tien, H; Hsee, L C; Spencer Netto, F; Speers, V; Rizoli, S B

    2010-01-01

    Thoracic injuries are potentially responsible for 25% of all trauma deaths. Chest X-ray is commonly used to screen patients with chest injury. However, the use of computed tomography (CT) scan for primary screening is increasing, particularly for blunt trauma. CT scans are more sensitive than chest X-ray in detecting intra-thoracic abnormalities such as pneumothoraces and pneumomediastinums. Pneumomediastinum detected by chest X-ray or "overt pneumomediastinum", raises the concern of possible aerodigestive tract injuries. In contrast, there is scarce information on the clinical significance of pneumomediastinum diagnosed by CT scan only or "occult pneumomediastinum". Therefore we investigated the clinical consequences of occult pneumomediastinum in our blunt trauma population. A 2-year retrospective chart review of all blunt chest trauma patients with initial chest CT scan admitted to a level I trauma centre. Data extracted from the medical records include; demographics, occult, overt, or no pneumomediastinum, the presence of intra-thoracic aerodigestive tract injuries (trachea, bronchus, and/or esophagus), mechanism and severity of injury, endotracheal intubation, chest thoracostomy, operations and radiological reports by an attending radiologist. All patients with intra-thoracic aerodigestive tract injuries from 1994 to 2004 were also investigated. Of 897 patients who met the inclusion criteria 839 (93.5%) had no pneumomediastinum. Five patients (0.6%) had overt pneumomediastinum and 53 patients (5.9%) had occult pneumomediastinum. Patients with occult pneumomediastinum had significantly higher ISS and AIS chest (pchest thoracostomy tube was more common (ppneumothorax. None of the patients with occult pneumomediastinum had aerodigestive tract injuries (95%CI 0-0.06). Follow up CT scan of patients with occult pneumomediastinum showed complete resolution in all cases, in average 3 h after the initial exam. Occult pneumomediastinum occurred in approximately 6% of

  7. Einstein unmasked

    Science.gov (United States)

    Foster, Brian

    2008-09-01

    This is a remarkable and, at times, bewilderingly diverse volume. Consisting of 20 essays that represent the proceedings of a conference held in 2005 in Berlin, Germany, during the International Year of Physics, it offers insights into Einstein's influence on a swathe of human activity. In the introduction the distinguished editors make some remarkable claims for the book, calling it "an unique attempt" and saying that "there is no better introduction to...string theory", while the first essay states "Not since Newton's Principia..." Clearly this is a volume that aspires to high standards.

  8. Greater trochanteric fracture with occult intertrochanteric extension.

    Science.gov (United States)

    Reiter, Michael; O'Brien, Seth D; Bui-Mansfield, Liem T; Alderete, Joseph

    2013-10-01

    Proximal femoral fractures are frequently encountered in the emergency department (ED). Prompt diagnosis is paramount as delay will exacerbate the already poor outcomes associated with these injuries. In cases where radiography is negative but clinical suspicion remains high, magnetic resonance imaging (MRI) is the study of choice as it has the capability to depict fractures which are occult on other imaging modalities. Awareness of a particular subset of proximal femoral fractures, namely greater trochanteric fractures, is vital for both radiologists and clinicians since it has been well documented that they invariably have an intertrochanteric component which may require surgical management. The detection of intertrochanteric or cervical extension of greater trochanteric fractures has been described utilizing MRI but is underestimated with both computed tomography (CT) and bone scan. Therefore, if MRI is unavailable or contraindicated, the diagnosis of an isolated greater trochanteric fracture should be met with caution. The importance of avoiding this potential pitfall is demonstrated in the following case of an elderly woman with hip pain and CT demonstrating an isolated greater trochanteric fracture who subsequently returned to the ED with a displaced intertrochanteric fracture.

  9. Visible and occult microscopic lesions of endometriosis

    Directory of Open Access Journals (Sweden)

    Khaleque Newaz Khan

    2014-11-01

    Full Text Available Endometriosis is a multifactorial disease mostly affecting women of reproductive age and is associated with chronic pelvic pain and infertility. Even after 300 years, most of the literature claims that pathogenesis and/or pathophysiology of endometriosis is still elusive. Recurrence of pain and lesion continues to occur after effective medical or surgical therapies. Once generated within the pelvis due to retrograde entry of menstrual debris, peritoneal endometriotic lesions time-dependently change their color appearance resulting from certain biochemical change within lesions. A variable pattern of endometriotic lesions within the pelvis can be detected by laparoscopy as visible peritoneal endometriosis. It is generally believed that besides ovarian steroid hormones, the growth of endometriosis can be regulated by the innate immune system in the pelvic microenvironment by their interaction with endometrial cells and immune cells. Even with the careful eyes of an expert surgeon, we may sometimes miss detecting peritoneal lesion within the peritoneal cavity or deep into the peritoneum. In such a case, random collection of normal peritoneum may carry the possibility to identify some hidden endometriotic lesions by microscopy and these lesions can be named as occult (invisible microscopic endometriosis (OME. Here, we discuss the color appearance of peritoneal lesions and activity of these lesions by analysis of a panel of activity markers. Finally we discuss our recent findings on OME, their biological and clinical significance, and try to make a possible link in the origin between visible endometriosis and OME.

  10. Celestial shadows eclipses, transits, and occultations

    CERN Document Server

    Westfall, John

    2015-01-01

    Much of what is known about the universe comes from the study of celestial shadows—eclipses, transits, and occultations.  The most dramatic are total eclipses of the Sun, which constitute one of the most dramatic and awe-inspiring events of nature.  Though once a source of consternation or dread, solar eclipses now lead thousands of amateur astronomers and eclipse-chasers to travel to remote points on the globe to savor their beauty and the adrenaline-rush of experiencing totality, and were long the only source of information about the hauntingly beautiful chromosphere and corona of the Sun.   Long before Columbus, the curved shadow of the Earth on the Moon during a lunar eclipse revealed that we inhabit a round world. The rare and wonderful transits of Venus, which occur as it passes between the Earth and the Sun, inspired eighteenth century expeditions to measure the distance from the Earth to the Sun, while the recent transits of 2004 and 2012 were the most widely observed ever--and still produced re...

  11. Hyper-chaos encryption using convolutional masking and model free unmasking

    International Nuclear Information System (INIS)

    Qi Guo-Yuan; Matondo Sandra Bazebo

    2014-01-01

    In this paper, during the masking process the encrypted message is convolved and embedded into a Qi hyper-chaotic system characterizing a high disorder degree. The masking scheme was tested using both Qi hyper-chaos and Lorenz chaos and indicated that Qi hyper-chaos based masking can resist attacks of the filtering and power spectrum analysis, while the Lorenz based scheme fails for high amplitude data. To unmask the message at the receiving end, two methods are proposed. In the first method, a model-free synchronizer, i.e. a multivariable higher-order differential feedback controller between the transmitter and receiver is employed to de-convolve the message embedded in the receiving signal. In the second method, no synchronization is required since the message is de-convolved using the information of the estimated derivative. (general)

  12. How electronic health records can unmask the hidden value of PAs.

    Science.gov (United States)

    Ogunfiditimi, Folusho; Sherry, Scott P; Foote, Monica; Christie, Sarah L; Shock, Lisa P; Cawley, James; Browne, Aaron

    2017-06-01

    The Fee for Value (FFV) Task Force, a subgroup of the American Academy of PAs' Research and Strategic Initiatives Commission, has examined tools and mechanisms aimed at better clarifying the volume and value of PA work and how that work contributes to improving access to high-quality care. Establishing the value of PAs has been a challenging task for many healthcare providers. Often, PA value has been defined by their clinical productivity, without any clear direction as to what constitutes value versus productivity. The objective of this article is to unmask the value of PAs through the role of electronic health records and highlight PAs' ability to produce services that are value-oriented and quantifiably productive.

  13. Context Effects in Forensic Entomology and Use of Sequential Unmasking in Casework.

    Science.gov (United States)

    Archer, Melanie S; Wallman, James F

    2016-09-01

    Context effects are pervasive in forensic science, and are being recognized by a growing number of disciplines as a threat to objectivity. Cognitive processes can be affected by extraneous context information, and many proactive scientists are therefore introducing context-minimizing systems into their laboratories. Forensic entomologists are also subject to context effects, both in the processes they undertake (e.g., evidence collection) and decisions they make (e.g., whether an invertebrate taxon is found in a certain geographic area). We stratify the risk of bias into low, medium, and high for the decisions and processes undertaken by forensic entomologists, and propose that knowledge of the time the deceased was last seen alive is the most potentially biasing piece of information for forensic entomologists. Sequential unmasking is identified as the best system for minimizing context information, illustrated with the results of a casework trial (n = 19) using this approach in Victoria, Australia. © 2016 American Academy of Forensic Sciences.

  14. Addiction screening and diagnostic tools: 'Refuting' and 'unmasking' claims to legitimacy.

    Science.gov (United States)

    Dwyer, Robyn; Fraser, Suzanne

    2015-12-01

    Human practices of all kinds - substance use, gambling, sex, even eating - are increasingly being reframed through the language of addiction. This 'addicting' of contemporary society is achieved, in part, through the screening and diagnostic tools intended to identify and measure addiction. These tools are a key element in the expert knowledge-making through which realities of addiction emerge. Promoted as objective and accurate, the tools are given legitimacy through application of scientific validation techniques. In this article, we critically examine the operations of these validation techniques as applied to substance addiction tools. Framed by feminist and other scholarship that decentres the epistemological guarantees of objectivity and validity, we structure our analysis using Ian Hacking's (1999) concepts of 'refuting' (showing a thesis to be false) and 'unmasking' (undermining a thesis). Under 'refuting', we consider the methodological validation processes on their own terms, identifying contradictory claims, weak findings and inconsistent application of methodological standards. Under 'unmasking', we critically analyse validation as a concept in itself. Here we identify two fundamental problems: symptom learning and feedback effects; and circularity and assumptions of independence and objectivity. Our analysis also highlights the extra-theoretical functions and effects of the tools. Both on their own terms and when subjected to more searching analysis, then, the validity claims the tools make fail to hold up to scrutiny. In concluding, we consider some of the effects of the processes we identify. Not only do these tools make certainty where there is none, we contend, they actively participate in the creation of social objects and social groups, and in shaping affected individuals and their opportunities. In unpacking in detail the legitimacy of the tools, our aim is to open up for further scrutiny the processes by which they go about making (rather than

  15. Recent progress on external occulter technology for imaging exosolar planets

    Science.gov (United States)

    Kasdin, N. J.; Vanderbei, R. J.; Sirbu, D.; Samuels, J.; Shaklan, S.; Lisman, D.; Thomson, M.; Cady, E.; Martin, S.

    Imaging planets orbiting nearby stars requires a system for suppressing the host starlight by at least ten orders of magnitude. One such approach uses an external occulter, a satellite flying far from the telescope and employing a large screen, or starshade, to suppress the incoming starlight. This trades the added complexity of building the precisely shaped starshade and flying it in formation against simplifications in the telescope since extremely precise wavefront control is no longer necessary. Much progress has been made recently in designing, testing and manufacturing starshade technology. In this paper we describe the design of starshades and report on recent accomplishments in manufacturing and measuring a prototype occulter petal as part of NASA's first Technology Development for Exoplanet Missions (TDEM) program. We demonstrate that the as-built petal is consistent with a full-size occulter achieving better than 10-10 contrast. We also discuss laboratory testing at the Princeton Occulter Testbed. These experiments use sub-scale, long-distance beam propagation to verify the diffraction analysis associated with occulter starlight suppression. We demonstrate roughly 10-10 suppression in the laboratory and discuss the important challenges and limitations.

  16. Crosslink Radio Occultation for the Remote Sensing of Planetary Atmospheres

    Science.gov (United States)

    Mannucci, A. J.; Ao, C. O.; Asmar, S.; Edwards, C. D.; Kahan, D. S.; Paik, M.; Pi, X.; Williamson, W.

    2015-12-01

    Radio occultation utilizing deep space telecommunication signals has been used with great success in the profiling of planetary atmospheres and ionospheres since the 1960s. A shortcoming of this technique, however, is the limited temporal and spatial sampling that it provides. We consider a different approach where radio occultation measurements are taken between two spacecraft orbiting an extra-terrestrial body. Such "crosslink" radio occultations between the Global Positioning System satellites and low-earth orbiting spacecraft have been routinely acquired to provide global observations of the Earth's atmosphere and ionosphere that are used for weather forecast, climate analysis, and space weather applications. The feasibility of applying this concept to other planets has recently been demonstrated for the first time, where crosslink occultation measurements have been acquired between the Mars Odyssey and Mars Reconnaissance Orbiter spacecraft. These measurements leverage the proximity link telecommunication payloads on each orbiter, which are nominally used to provide relay communication and navigation services to Mars landers and rovers. In this presentation, we will describe the Mars crosslink experiments and the corresponding data analysis in detail. In addition, we will discuss how the crosslink occultation concepts can be effectively applied in future space exploration missions.

  17. [Occultism, parapsychology and the esoteric from the perspective of psychopathology].

    Science.gov (United States)

    Scharfetter, C

    1998-10-01

    The concepts and main themes of occultism, parapsychology and esoterics are set in comparison to religion, spirituality, mysticism. The cultural relativity of these concepts is emphasised. Occultism means dealing with phenomena, processes, and/or powers which are not accessible to "normal perception". The manipulation of such powers is effected via (white, black, grey) magic. Parapsychology, in its popular sense, deals with occult phenomena, whereas scientific parapsychology investigates them empirically. Esoterics is a complex of beliefs within a hermetic tradition about occult processes and about desting after death. Transpersonal psychology deals with these issues while calling them "spiritual". Effects of paranormal experiences and actions on the side of the actor as well as the adept are discussed: personality types, interpersonal effects, crises and psychoses (mediumistic psychoses). The concept of dissociation of subpersonalities (subselves) appears to be a viable perspective to explain these phenomena. In mediumistic psychoses, the splitting of non-ego parts of the psyche leads to a manifestation of schizophrenic symptoms. Dangers for mental health are an ego inflation by self-attribution of "superhuman" power. A personality disposition for parapsychological perception and/or action may be seen in schizotypia and similar near-psychotic "personalities up the border". Adepts of occultism may present with a "false self" in the sense of Winnicott.

  18. David Levy's Guide to Eclipses, Transits, and Occultations

    Science.gov (United States)

    Levy, David H.

    2010-08-01

    Introduction; Part I. The Magic and History of Eclipses: 1. Shakespeare, King Lear, and the Great Eclipse of 1605; 2. Three centuries later: Einstein, relativity, and the solar eclipse of 1919; 3. What causes solar and lunar eclipses; Part II. Observing Solar Eclipses: 4. Safety considerations; 5. What to expect during a partial eclipse; 6. Annular eclipses and what to see in them; 7. Total eclipse of the Sun: introduction to the magic; 8. The onset: temperature drop, Baily's Beads, Diamond Ring; 9. Totality: Corona, Prominences, Chromosphere, and surrounding area; 10. Photographing and imaging a solar eclipse; Part III. Observing Lunar Eclipses: 11. Don't forget the penumbral eclipses!; 12. Partial lunar eclipses; 13. Total lunar eclipses; 14. Photographing and imaging lunar eclipses; Part IV. Occultations: 15. When the Moon occults a star; Part V. Transits: 16. When planets cross the Sun; Part VI. My Favorite Eclipses: 17. A personal canon of eclipses, occultations, and transits I have seen; Appendices; Index.

  19. Operation of the Radio Occultation Mission in KOMPSAT-5

    Directory of Open Access Journals (Sweden)

    Mansoo Choi

    2010-12-01

    Full Text Available Korea multi-purpose satellite-5 (KOMPSAT-5 is a low earth orbit (LEO satellite scheduled to be launched in 2010. To satisfy the precision orbit determination (POD requirement for a high resolution synthetic aperture radar image of KOMPSAT-5, KOMPSAT-5 has atmosphere occultation POD (AOPOD system which consists of a space-borne dual frequency global positioning system (GPS receiver and a laser retro reflector array. A space-borne dual frequency GPS receiver on a LEO satellite provides position data for the POD and radio occultation data for scientific applications. This paper describes an overview of AOPOD system and operation concepts of the radio occultation mission in KOMPSAT-5. We showed AOPOD system satisfies the requirements of KOMPSAT-5 in performance and stability.

  20. Categorizing the Occult: Vodun, Sorcery and Religious Beliefs In Benin

    DEFF Research Database (Denmark)

    Strandsbjerg, Camilla

    2011-01-01

    In everyday life in Benin as well as in academic research on the topic, the terms of vodun, witchcraft and the occult are often used in a non distinct way covering quite similar phenomena while at the same time referring to different kinds of beliefs and practices. The problem of understanding...... confronted with this difficulty. Both because the vodun, as a recognized religion in the country - equal to Islam and Christianity - , plays an important role in society as well as in individual life, but also because all area of social life are on one level or another influenced by beliefs and practices...... characterized as witchcraft or occult. Reflecting upon earlier research and particularly on the choice of terminology of the occult in writing on religion and political change in Benin (PhD thesis 2008), this paper seeks to clarify some of the epistemological, academic and historical reasons that have formed...

  1. Stress

    Science.gov (United States)

    ... taking care of an aging parent. With mental stress, the body pumps out hormones to no avail. Neither fighting ... with type 1 diabetes. This difference makes sense. Stress blocks the body from releasing insulin in people with type 2 ...

  2. The stellar occultation by the dwarf planet Haumea

    Science.gov (United States)

    Santos-Sanz, Pablo; Ortiz, Jose Luis; Sicardy, Bruno; Rossi, Gustavo; Berard, Diane; Morales, Nicolas; Duffard, Rene; Braga-Ribas, Felipe; Hopp, Ulrich; Ries, Christoph; Nascimbeni, Valerio; Marzari, Francesco; Granata, Valentina; Pál, András; Kiss, Csaba; Pribulla, Theodor; Milan Komzík, Richard; Hornoch, Kamil; Pravec, Petr; Bacci, Paolo; Maestripieri, Martina; Nerli, Luca; Mazzei, Leonardo; Bachini, Mauro; Martinelli, Fabio; Succi, Giacomo; Ciabattari, Fabrizio; Mikuz, Herman; Carbognani, Albino; Gaehrken, Bernd; Mottola, Stefano; Hellmich, Stephan; Rommel, Flavia; Fernández-Valenzuela, Estela; Campo Bagatin, Adriano; Haumea occultation international Collaboration: https://cloud.iaa.csic.es/public.php?service=files&t=d9276f8ab1a316cef13bee28bef75add

    2017-10-01

    The dwarf planet Haumea is a very peculiar Trans-Neptunian Object (TNO) with unique and exotic characteristics. It is currently classified as one of the five dwarf planets of the solar system, and it is the only one for which size, shape, albedo, density and other basic properties were not accurately known. To solve that we predicted an occultation of the star GaiaDR1 1233009038221203584 by Haumea and organized observations within the expected shadow path. Medium/large telescopes were needed to record the occultation with enough signal to noise ratio because the occulted star is of similar brightness as Haumea (R~17.7 mag). We will report results derived from this successful stellar occultation by Haumea on 2017 January 21st. The occultation was positive from 12 telescopes at 10 observing stations in Europe: the Asiago Observatory 1.8m telescope (Italy), the Mount Agliale Observatory 0.5m telescope (Italy), the Lajatico Astronomical Centre 0.5m telescope (Italy), the S.Marcello Pistoiese Observatory 0.6m telescope (Italy), the Crni Vrh Observatory 0.6m telescope (Slovenia), the Ondrejov Observatory 0.65m telescope (Czech Republic), the Bavarian Public Observatory 0.81m telescope (Germany), the Konkoly Observatory 1m and 0.6m telescopes (Hungary), the Skalnate Pleso Observatory 1.3m telescope (Slovakia), and the Wendelstein Observatory 2m and 0.4m telescopes (Germany). This is the occultation by a TNO with the largest number of chords ever recorded.Part of this work has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 687378.

  3. Exploring small bodies in the outer solar system with stellar occultations

    Science.gov (United States)

    Elliot, Jim L.; Dunham, Edward W.; Olkin, C. B.

    1995-01-01

    Stellar occultation observations probe the atmospheric structure and extinction of outer solar system bodies with a spatial resolution of a few kilometers, and an airborne platform allows the observation of occultations by small bodies that are not visible from fixed telescopes. Results from occultations by Triton, Pluto, and Chiron observed with KAO are discussed, and future directions for this program are presented.

  4. Predictions of stellar occultations by TNOs/Centaurs using Gaia

    Science.gov (United States)

    Desmars, Josselin; Camargo, Julio; Berard, Diane; Sicardy, Bruno; Leiva, Rodrigo; Vieira-Martins, Roberto; Braga-Ribas, Felipe; Assafin, Marcelo; Rossi, Gustavo; Chariklo occultations Team, Rio Group, Lucky Star Occultation Team, Granada Occultation Team

    2017-10-01

    Stellar occultations are the unique technique from the ground to access physical parameters of the distant solar system objects, such as the measure of the size and the shape at kilometric level, the detection of tenuous atmospheres (few nanobars), and the investigation of close vicinity (satellites, rings, jets).Predictions of stellar occultations require accurate positions of the star and the object.The Gaia DR1 catalog now allows to get stellar position to the milliarcsecond (mas) level. The main uncertainty in the prediction remains in the position of the object (tens to hundreds of mas).Now, we take advantage of the NIMA method for the orbit determination that uses the most recent observations reduced by the Gaia DR1 catalog and the astrometric positions derived from previous positive occultations.Up to now, we have detected nearly 50 positive occultations for about 20 objects that provide astrometric positions of the object at the time of the occultation. The uncertainty of these positions only depends on the uncertainty on the position of the occulted stars, which is a few mas with the Gaia DR1 catalog. The main limitation is now on the proper motion of the star which is only given for bright stars in the Tycho-Gaia Astrometric Solution. This limitation will be solved with the publicationof the Gaia DR2 expected on April 2018 giving proper motions and parallaxes for the Gaia stars. Until this date, we use hybrid stellar catalogs (UCAC5, HSOY) that provide proper motions derived from Gaia DR1 and another stellar catalog.Recently, the Gaia team presented a release of three preliminary Gaia DR2 stellar positions involved in the occultations by Chariklo (22 June and 23 July 2017) and by Triton (5 October 2017).Taking the case of Chariklo as an illustration, we will present a comparison between the proper motions of DR2 and the other catalogs and we will show how the Gaia DR2 will lead to a mas level precision in the orbit and in the prediction of stellar

  5. Presentation of Axillary Metastases from Occult Breast Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Xin Wang

    2007-01-01

    Axillary presentation from occult breast cancer is uncommon and continues to be a diagnostic and therapeutic challenge to physicians.Once the diagnosis of adenocarcinoma metastatic to an axillary lymph node has been confirmed,a preoperative workup should be done.The current experience is based on several relatively small retrospective reviews and case reports.It is difficult to determine the best management of occult breast cancer.However,treatmenl of axillary Iymph node dissection is recommended for local control and complete staging information.Treatment of breast should be a choice between breast conservation with whole-breast radiotherapy and mastectomy.Adjuvant systemic treatment should be offered.

  6. Detection of occult abscesses with 111In-labeled leukocytes

    International Nuclear Information System (INIS)

    Martin, W.R.; Gurevich, N.; Goris, M.L.; McDougall, I.R.

    1979-01-01

    Clinicians are frequently faced with the problem of a patient in whom they suspect an occult abscess. In such a situation, there may be no clinical signs to localize the site of the abscess and often extensive investigations do not provide additional useful information. This report illustrates the efficacy of autologous leukocytes labeled with 111 In oxine in detecting the site and extent of occult abscesses in two patients. The technique of in vitro lebeling of leukocytes is simple and has been mastered by all of our nuclear medicine technologists

  7. Exercise haemodynamics may unmask the diagnosis of diastolic dysfunction among patients with pulmonary hypertension.

    Science.gov (United States)

    Maor, Elad; Grossman, Yoni; Balmor, Ronen Gingy; Segel, Michael; Fefer, Paul; Ben-Zekry, Sagit; Buber, Jonathan; DiSegni, Elio; Guetta, Victor; Ben-Dov, Issahar; Segev, Amit

    2015-02-01

    Heart failure with preserved ejection fraction can lead to pulmonary hypertension. The aim of the present study was to evaluate the role of exercise during right heart catheterization in the unmasking of diastolic dysfunction. Between 2004 and 2012, 200 symptomatic patients with exertional dyspnoea, preserved left ventricular systolic function and suspected pulmonary hypertension, underwent right heart catheterization. Included in the study were 63 patients with resting pulmonary arterial wedge pressure (PAWP) ≤15 mmHg. Patients were divided to three tertiles based on their peak exercise PAWP. Mean age was 60 ± 20 years and 29% were males. Mean pulmonary arterial pressure was 31 ± 14 mmHg at rest and 42 ± 18 mmHg upon exercise. Mean change in PAWP between rest and exercise was 0.0 ± 4.3, 4.6 ± 2.4, and 16.6 ± 7.1 mmHg in the lower, middle, and upper tertiles, respectively (P exercise PAWP tertiles were associated with reduced pulmonary vascular resistance (8.3 ± 6.7, 2.9 ± 2.7, and 5.8 ± 4.6 Woods units, respectively; P = 0.004). A multivariate linear regression model demonstrated that each 5 kg/m(2) increase in body mass index was associated with 2.5 ± 1.0 mmHg increase in exercise PAWP (P = 0.017). A multivariate binary logistic model showed that subjects with borderline PAWP at rest (12-15 mmHg) were 4.5 times more likely to be in the upper tertile of exercise PAWP (P = 0.011). In symptomatic patients with pulmonary hypertension, preserved left ventricular ejection fraction and PAWP ≤15 mmHg, exercise during right heart catheterization may unmask diastolic dysfunction. This is especially true for obese patients and patients with borderline resting PAWP. © 2014 The Authors. European Journal of Heart Failure © 2014 European Society of Cardiology.

  8. Molecular and serological detection of occult hepatitis B virus ...

    African Journals Online (AJOL)

    hepatitis B surface antigen-negative blood donors in Malaysia. ... Objective: This study aimed to detect occult hepatitis B virus in hepatitis B surface .... of the standard HBV-positive serum and the detection ... in general population ranges from 1.5 to 9.8% but report- .... Putra, Malaysia for their financial support of this research.

  9. Occult hepatitis B among Iranian hepatitis C patients

    Directory of Open Access Journals (Sweden)

    Ahmad shavakhi

    2009-02-01

    Full Text Available

    • BACKGROUND: Occult hepatitis B is defined as presence of HBV DNA in tissue or serum without hepatitis B surface antigen. The aim of this study is to determine frequency of occult hepatitis B among hepatitis C patients in Tehran and compare the route of transmission and liver enzymes between positive and negative HBV DNA patients.
    • METHODS: In a cross sectional study, serum of 103 hepatitis C cases (79.6% men and 20.4% women were analyzed for s, x and core genes via a nested polymerase chain reaction technique.
    • RESULTS: HBV DNA was detectable in serum of 20 patients (19.4%. No significant difference in age, sex and route of transmission were seen in HBV DNA positive and negative patients. In HBV DNA positive and negative groups, mean of AST was 73, 47 (p < 0.05 and mean of ALT was 76 and 36 respectively (p < 0.05.
    • CONCLUSION: Occult hepatitis B was observed in a considerable number of hepatitis C patients in Tehran. It was associated with elevation in liver enzyme but was not related to route of transmission.
    • KEY WORD: Occult hepatitis B, hepatitis C, cirrhosis.

  10. Detection of occult HBV infection by nested PCR assay among ...

    African Journals Online (AJOL)

    Occult hepatitis B virus infection (OBI) has been reported among patients with chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC). This study aimed to evaluate the prevalence of OBI in chronic hepatitis C patients with and without hepatocellular carcinoma. A total of 40 chronic hepatitis C patients ...

  11. Occult hepatitis B virus infection in immunocompromised patients

    Directory of Open Access Journals (Sweden)

    Ruth Nogueira Cordeiro Moraes Jardim

    Full Text Available Occult hepatitis B infection is characterized by hepatitis B virus (HBV DNA in the serum in the absence of hepatitis B surface antigen (HBsAg. We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.

  12. Occult spontaneous lateral intrasphenoidal encephalocele: A rare presentation

    Directory of Open Access Journals (Sweden)

    Shahina Bano

    2013-01-01

    Full Text Available Basal encephaloceles are extremely rare congenital malformations. Advanced cross-sectional imaging modalities like computed tomography and magnetic resonance imaging are necessary for diagnosing the asymptomatic, occult basal encephalocele and planning the surgical approach. We present an interesting case of clinically silent right-sided lateral intrasphenoidal encephalocele through a large bony defect.

  13. Occurrence of occult CSF leaks during standard FESS procedures.

    Science.gov (United States)

    Bucher, S; Kugler, A; Probst, E; Epprecht, L; Stadler, R S; Holzmann, D; Soyka, M B

    2018-03-18

    To determine the incidence of occult cerebrospinal fluid leaks (CSF) after functional endoscopic sinus surgery (FESS) and to evaluate the diagnostic performance of beta2-transferrin in blood-contaminated conditions. Prospective cohort study. An analysis of 57 intraoperative samples using hydrogel 6 beta2-transferrin assay after FESS was undertaken. In case of CSF positive samples and continuing rhinorrhea, reanalysis after more than 1 year was conducted. In-vivo analysis of a primary spontaneous CSF leak sample took place to verify difficulties in detecting beta2-transferrin in blood-contaminated settings. Own titrations were performed to evaluate detection limits of CSF by beta2-transferrin and beta-trace protein assays in these settings. An incidence of 13% for occult CSF leaks after FESS was found. In blood-contaminated conditions, routine beta2-transferrin assays showed low sensitivity. In over 1 year follow-up, all samples were negative for CSF and none of them developed clinical relevant CSF leaks or meningitis. Occult and clinically irrelevant CSF leaks do occur in a significant proportion of patients during and shortly after FESS. Intra- and postoperatively, routine beta2-transferrin assays show low sensitivity. They should not be used in these settings. The clinical course of patients with occult CSF leaks indicated possibility of an uneventful follow-up.

  14. Pluto-Charon Stellar Occultation Candidates: 1990-1995

    Science.gov (United States)

    Dunham, E. W.; McDonald, S. W.; Elliot, J. L.

    1991-01-01

    We have carried out a search to identify stars that might be occulted by Pluto or Charon during the period 1990-1995 and part of 1996. This search was made with an unfiltered CCD camera operated in the strip scanning mode, and it reaches an R magnitude of approximately 17.5-about 1.5 mag fainter than previous searches. Circumstances for each of the 162 potential occultations are given, including an approximate R magnitude of the star, which allows estimation of the signal-to-noise ratio (S/N) for observation of each occultation. The faintest stars in our list would yield an S/N of about 20 for a 1 S integration when observed with a CCD detector on an 8 m telescope under a dark sky. Our astrometric precision (+/- 0.2 arcsec, with larger systematic errors possible for individual cases) is insufficient to serve as a final prediction for these potential occultations, but is sufficient to identify stars deserving of further, more accurate, astrometric observations. Statistically, we expect about 32 of these events to be observable somewhere on Earth. The number of events actually observed will be substantially smaller because of clouds and the sparse distribution of large telescopes. Finder charts for each of the 91 stars involved are presented.

  15. Radio occultation bending angle anomalies during tropical cyclones

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Neubert, Torsten; Syndergaard, S.

    2011-01-01

    -located radiosondes, climatology of tropopause altitudes and GOES analyses are also shown to support the hypothesis that the bending angle anomaly can be used as an indicator of convective towers. The results are discussed in connection to the GPS radio occultation receiver which will be part of the Atomic Clock...

  16. Past and future of radio occultation studies of planetary atmospheres

    Science.gov (United States)

    Eshleman, Von R.; Hinson, David P.; Tyler, G. Leonard; Lindal, Gunnar F.

    1987-01-01

    Measurements of radio waves that have propagated through planetary atmospheres have provided exploratory results on atmospheric constituents, structure, dynamics, and ionization for Venus, Mars, Titan, Jupiter, Saturn, and Uranus. Highlights of past results are reviewed in order to define and illustrate the potential of occultation and related radio studies in future planetary missions.

  17. A method to detect occult pneumothorax with chest radiography.

    Science.gov (United States)

    Matsumoto, Shokei; Kishikawa, Masanobu; Hayakawa, Koichi; Narumi, Atsushi; Matsunami, Katsutoshi; Kitano, Mitsuhide

    2011-04-01

    Small pneumothoraces are often not visible on supine screening chest radiographs because they develop anteriorly to the lung. These pneumothoraces are termed occult. Occult pneumothoraces account for an astonishingly high 52% to 63% of all traumatic pneumothoraces. A 19-year-old obese woman was involved in a head-on car accident. The admission anteroposterior chest radiographs were unremarkable. Because of the presence of right chest tenderness and an abrasion, we suspected the presence of a pneumothorax. Thus, we decided to take a supine oblique chest radiograph of the right side of the thorax, which clearly revealed a visceral pleural line, consistent with a diagnosis of traumatic pneumothorax. A pneumothorax may be present when a supine chest radiograph reveals either an apparent deepening of the costophrenic angle (the "deep sulcus sign") or the presence of 2 diaphragm-lung interfaces (the "double diaphragm sign"). However, in practice, supine chest radiographs have poor sensitivity for occult pneumothoraces. Oblique chest radiograph is a useful and fast screening tool that should be considered for cases of blunt chest trauma, especially when transport of critically ill patients to the computed tomographic suite is dangerous or when imminent transfer to another hospital is being arranged and early diagnosis of an occult pneumothorax is essential. Copyright © 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

  18. Occult Metabolic Bone Disease in Chronic Pancreatitis | Hari Kumar ...

    African Journals Online (AJOL)

    Background: Chronic pancreatitis (CP) leads to malabsorption and metabolic bone disease (MBD). Alcoholic CP (ACP) and tropical CP (TCP) are the two common types of CP. Objective: We investigated the presence of occult MBD in patients with CP and compared the same between ACP and TCP. Materials and Methods: ...

  19. Precise pointing knowledge for SCIAMACHY solar occultation measurements

    Directory of Open Access Journals (Sweden)

    K. Bramstedt

    2012-11-01

    Full Text Available We present a method to precisely determine the viewing direction for solar occultation instruments from scans over the solar disk. Basic idea is the fit of the maximum intensity during the scan, which corresponds to the center of the solar disk in the scanning direction. We apply this method to the solar occultation measurements of the satellite instrument SCIAMACHY, which scans the Sun in elevation direction. The achieved mean precision is 0.46 mdeg, which corresponds to an tangent height error of about 26 m for individual occultation sequences. The deviation of the derived elevation angle from the geolocation information given along with the product has a seasonal cycle with an amplitude of 2.26 mdeg, which is in tangent height an amplitude of about 127 m. The mean elevation angle offset is −4.41 mdeg (249 m. SCIAMACHY's sun follower device controls the azimuth viewing direction during the occultation measurements. The derived mean azimuth direction has an standard error of 0.65 mdeg, which is about 36 m in horizontal direction at the tangent point. We observe also a seasonal cycle of the azimuth mispointing with an amplitude of 2.3 mdeg, which is slightly increasing with time. The almost constant mean offset is 88 mdeg, which is about 5.0 km horizontal offset at the tangent point.

  20. Sensing Water Vapon via Spacecraft Radio Occultation Observations

    Science.gov (United States)

    Kursinski, E. Robert; Hajj, George A.

    2000-01-01

    The radio occultation technique has been used to characterize planetary atmospheres since the 1960's spanning atmospheric pressures from 16 microbars to several bars. In 1988, the use of GPS signals to make occultation observations of Earth's atmosphere was realized by Tom Yunck and Gunnar Lindal at JPL. In the GPS to low-Earth-orbiter limb- viewing occultation geometry, Fresnel diffraction yield a unique combination of high vertical resolution of 100 m to 1 km at long wavelengths (approx. 20 cm) insensitive to particulate scattering which allows routine limb sounding from the lower mesosphere through the troposphere. A single orbiting GPS/GLONASS receiver can observe - 1000 to 1400 daily occultations providing as many daily, high vertical resolution soundings as the present global radiosonde network, but with far more evenly distributed, global coverage. The occultations yield profiles of refractivity as a function of height. In the cold, dry conditions of the upper troposphere and above (T less than 240 K), profiles of density, pressure (geopotential), and temperature can be derived. Given additional temperature information, water vapor can be derived in the midddle and lower troposphere with a unique combination of vertical resolution, global distribution and insensitivity to clouds and precipitation to an accuracy of approx. 0.2 g/kg. At low latitudes, moisture profiles will be accurate to 1-5% within the convective boundary layer and better than 20% below 6 to 7 km. Accuracies of climatological averages should be approx. 0. 1 g/kg limited by the biases in the temperature estimates. To use refractivity to constrain water vapor, knowledge of temperature is required. The simplest approach is to use the temperature field from an analysis such as the 6 hour ECMWF global analysis interpolated to the locations of each occultation. A better approach is to combine the temperature and moisture fields from such an analysis with the occultation refractivity in a weighting

  1. Occult Pneumothoraces in Acute Trauma Patients

    Directory of Open Access Journals (Sweden)

    Chad Berryman

    2012-12-01

    Full Text Available Introduction: Many traumatic pneumothoraces (PTX are not seen on initial chest radiograph (CR(occult PTX but are detected only on computed tomography (CT. Although CR remains the first toolfor detecting PTX, most trauma patients with significant thoracoabdominal injuries will receive both CTand CR. The primary objective of this study was to retrospectively determine the effectiveness of CR fordetecting PTX in trauma patients. Our hypotheses were that CR is a sensitive indicator of PTX on CT,that chest pain and shortness of breath are good predictors of PTX on CR, and that we could determineother predictors of PTX on CR.Methods: All trauma patients presenting to our Level I trauma center with a CT-diagnosed PTX over a2-year period who had both a CR and a chest CT were included. The CT reading was considered thegold standard for PTX diagnosis. Electronic medical records were searched using key words fordiagnoses, symptoms, demographics, and radiologic results. We recorded the official radiologistreadings for both CR and CT (positive or negative and the size of the PTX on CT (large, moderate,small, or tiny. The outcome variable was dichotomized based on presence or absence of PTXdetected on CR. Descriptive statistics and v2 tests were used for univariate analysis. A regressionanalysis was performed to determine characteristics predictive of a PTX on CR, and 1 variable wasadded to the model for every 10 positive CRs. With equal-size groups, this study has the power of 80%to detect a 10% absolute difference in single predictors of PTX on CR with 45 subjects in each group.Results: There were 134 CT-documented PTXs included in the study. Mean age was 42, and 74%were men. For 66 (49% patients, PTX was detected on CR (sensitivity¼50%. The CR detected 30%of small PTX, 35% of moderate PTX, and 33% of large PTX. Comparing patients with and without PTXon CR, there were no significant differences in shortness of breath or chest pain. There no

  2. Occult pneumothoraces in acute trauma patients.

    Science.gov (United States)

    Ernst, Amy A; McIntyre, William A; Weiss, Steven J; Berryman, Chad

    2012-11-01

    Many traumatic pneumothoraces (PTX) are not seen on initial chest radiograph (CR) (occult PTX) but are detected only on computed tomography (CT). Although CR remains the first tool for detecting PTX, most trauma patients with significant thoracoabdominal injuries will receive both CT and CR. The primary objective of this study was to retrospectively determine the effectiveness of CR for detecting PTX in trauma patients. Our hypotheses were that CR is a sensitive indicator of PTX on CT, that chest pain and shortness of breath are good predictors of PTX on CR, and that we could determine other predictors of PTX on CR. All trauma patients presenting to our Level I trauma center with a CT-diagnosed PTX over a 2-year period who had both a CR and a chest CT were included. The CT reading was considered the gold standard for PTX diagnosis. Electronic medical records were searched using key words for diagnoses, symptoms, demographics, and radiologic results. We recorded the official radiologist readings for both CR and CT (positive or negative) and the size of the PTX on CT (large, moderate, small, or tiny). The outcome variable was dichotomized based on presence or absence of PTX detected on CR. Descriptive statistics and χ(2) tests were used for univariate analysis. A regression analysis was performed to determine characteristics predictive of a PTX on CR, and 1 variable was added to the model for every 10 positive CRs. With equal-size groups, this study has the power of 80% to detect a 10% absolute difference in single predictors of PTX on CR with 45 subjects in each group. There were 134 CT-documented PTXs included in the study. Mean age was 42, and 74% were men. For 66 (49%) patients, PTX was detected on CR (sensitivity = 50%). The CR detected 30% of small PTX, 35% of moderate PTX, and 33% of large PTX. Comparing patients with and without PTX on CR, there were no significant differences in shortness of breath or chest pain. There no relationships between PTX detected

  3. Failure to unmask pseudonormal diastolic function by a valsalva maneuver: tricuspid insufficiency is a major factor.

    Science.gov (United States)

    Hu, Kai; Liu, Dan; Niemann, Markus; Hatle, Liv; Herrmann, Sebastian; Voelker, Wolfram; Ertl, Georg; Bijnens, Bart; Weidemann, Frank

    2011-11-01

    For the clinical assessment of patients with dyspnea, the inversion of the early (E) and late (A) transmitral flow during Valsalva maneuver (VM) frequently helps to distinguish pseudonormal from normal filling pattern. However, in an important number of patients, VM fails to reveal the change from dominant early mitral flow velocity toward larger late velocity. From December 2009 to October 2010, we selected consecutive patients with abnormal filling with (n=25) and without E/A inversion (n=25) during VM. Transmitral, tricuspid, and pulmonary Doppler traces were recorded and the degree of insufficiency was estimated. After evaluating all standard echocardiographic morphological, functional, and flow-related parameters, it became evident that the failure to unmask the pseudonormal filling pattern by VM was related to the degree of the tricuspid insufficiency (TI). TI was graded as mild in 24 of 25 patients in the group with E/A inversion during VM, whereas TI was graded as moderate to severe in 24 of the 25 patients with pseudonormal diastolic function without E/A inversion during VM. Our data suggest that TI is a major factor to prevent E/A inversion during a VM in patients with pseudonormal diastolic function. This probably is due to a decrease in TI resulting in an increase in forward flow rather than the expected decrease during the VM. Thus, whenever a pseudonormal diastolic filling pattern is suspected, the use of a VM is not an informative discriminator in the presence of moderate or severe TI.

  4. Efficacy and safety of dextrose-insulin in unmasking non-diagnostic Brugada ECG patterns.

    Science.gov (United States)

    Velázquez-Rodríguez, Enrique; Rodríguez-Piña, Horacio; Pacheco-Bouthillier, Alex; Jiménez-Cruz, Marcelo Paz

    Typical diagnostic, coved-type 1, Brugada ECG patterns fluctuate spontaneously over time with a high proportion of non-diagnostic ECG patterns. Insulin modulates ion transport mechanisms and causes hyperpolarization of the resting potential. We report our experience with unmasking J-ST changes in response to a dextrose-insulin test. Nine patients, mean age 40.5±19.4years (range: 15-65years), presented initially with a non-diagnostic ECG pattern, which was suggestive of Brugada syndrome (group I). They were compared with 10 patients with normal ECG patterns (group II). Participants received an infusion of 50g of 50% dextrose, followed by 10IU of intravenous regular insulin. Positive changes were defined by conversion to a diagnostic ECG pattern. The dextrose-insulin test was positive in six of seven (85.7%) patients (kappa 0.79, p=0.02) that was confirmed with a pharmacologic test (kappa 1, p=0.003). One had an inconclusive test, and two with a negative test had an early repolarization ECG pattern. All subjects in group II had a negative test (pECG patterns. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Long QT syndrome unmasked in an adult subject presenting with excited delirium.

    Science.gov (United States)

    Bozeman, William P; Ali, Karim; Winslow, James E

    2013-02-01

    Excited delirium is increasingly recognized as a risk factor for sudden death, though the specific pathophysiology of these deaths is typically unclear. We describe a survivor of excited delirium that displayed a transient severe prolongation of the QT interval, suggesting unmasking of long QT syndrome as a possible mechanism of sudden death. A 30-year-old man was arrested by police for violent assaultive behavior. Officers at the scene noted confusion, nonsensical speech, sweating, and bizarre agitated behavior; he was transported to the Emergency Department for medical evaluation of possible excited delirium. His initial electrocardiogram revealed a markedly prolonged corrected QT interval of over 600 ms. Intravenous hydration and sodium bicarbonate were administered, with normalization of the QT; he was admitted and recovered uneventfully. We discuss the possible association between long QT syndrome and unexplained sudden deaths seen with excited delirium. Sodium bicarbonate may be considered when long QT syndrome is identified during or after agitated delirium, though its routine use cannot be recommended based on a case report. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Processing of masked and unmasked emotional faces under different attentional conditions: an electrophysiological investigation.

    Directory of Open Access Journals (Sweden)

    Marzia eDel Zotto

    2015-10-01

    Full Text Available In order to investigate the interactions between non-spatial selective attention, awareness and emotion processing, we carried out an ERP study using a backward masking paradigm, in which angry, fearful, happy and neutral facial expressions were presented, while participants attempted to detect the presence of one or the other category of facial expressions in the different experimental blocks. ERP results showed that negative emotions enhanced an early N170 response over temporal-occipital leads in both masked and unmasked conditions, independently of selective attention. A later effect arising at the P2 was linked to awareness. Finally, selective attention was found to affect the N2 and N3 components over occipito-parietal leads. Our findings reveal that i the initial processing of facial expressions arises prior to attention and awareness; ii attention and awareness give rise to temporally distinct periods of activation independently of the type of emotion with only a partial degree of overlap; and iii selective attention appears to be influenced by the emotional nature of the stimuli, which in turn impinges on unconscious processing at a very early stage. This study confirms previous reports that negative facial expressions can be processed rapidly, in absence of visual awareness and independently of selective attention. On the other hand, attention and awareness may operate in a synergistic way, depending on task demand.

  7. Metoclopramide unmasks potentially misleading contralateral suppression in patients undergoing adrenal vein sampling for primary aldosteronism.

    Science.gov (United States)

    Rossitto, Giacomo; Miotto, Diego; Battistel, Michele; Barbiero, Giulio; Maiolino, Giuseppe; Bisogni, Valeria; Sanga, Viola; Rossi, Gian Paolo

    2016-11-01

    As metoclopramide stimulates aldosterone secretion, we tested its usefulness in the assessment of lateralization of primary aldosteronism by adrenal vein sampling (AVS). Prospective within-patient study in consecutive patients undergoing AVS for primary aldosteronism subtyping. We compared the diagnostic accuracy of baseline and postmetoclopramide lateralization index and relative (to cortisol) aldosterone secretion indices (RASI) for each adrenal gland with aldosterone-producing adenoma (APA) determined by the four corners criteria as the reference diagnosis. We recruited 93 consecutive patients (mean age: 52 years; women 31%). Metoclopramide increased plasma aldosterone in the inferior vena cava and in both adrenal veins. The postmetoclopramide lateralization index was accurate in identifying APA, but did not increase diagnostic accuracy over baseline lateralization index, because the RASI increased similarly in both sides. Conversely, metoclopramide raised RASI to values more than 0.90 bilaterally in non-APA patients allowing accurate identification of factitious aldosterone suppression. In contrast, RASI was 0.90 or less in 48% contralateral to the tumor in APA patients. Regression analysis showed the APA patients with persistent suppression of RASI contralaterally showed a more florid primary aldosteronism phenotype. Metoclopramide does not enhance lateralization of aldosterone excess in APA, but consistently increased the value of RASI in non-APA cases, thus unmasking potentially misleading suppression of aldosterone. Postmetoclopramide RASI may therefore allow a more precise diagnosis when AVS can be achieved only unilaterally.

  8. Stress

    DEFF Research Database (Denmark)

    Keller, Hanne Dauer

    2015-01-01

    Kapitlet handler om stress som følelse, og det trækker primært på de få kvalitative undersøgelser, der er lavet af stressforløb.......Kapitlet handler om stress som følelse, og det trækker primært på de få kvalitative undersøgelser, der er lavet af stressforløb....

  9. Stress !!!

    OpenAIRE

    Fledderus, M.

    2012-01-01

    Twee op de vijf UT-studenten hebben last van ernstige studiestress, zo erg zelfs dat het ze in hun privéleven belemmert. Die cijfers komen overeen met het landelijk beeld van stress onder studenten. Samen met 14 andere universiteits- en hogeschoolbladen enquêteerde UT Nieuws bijna 5500 studenten. Opvallend is dat mannelijke studenten uit Twente zich veel minder druk lijken te maken over hun studie. Onder vrouwen ligt de stress juist erg hoog ten opzichte van het landelijk gemiddelde.

  10. Error analysis for mesospheric temperature profiling by absorptive occultation sensors

    Directory of Open Access Journals (Sweden)

    M. J. Rieder

    Full Text Available An error analysis for mesospheric profiles retrieved from absorptive occultation data has been performed, starting with realistic error assumptions as would apply to intensity data collected by available high-precision UV photodiode sensors. Propagation of statistical errors was investigated through the complete retrieval chain from measured intensity profiles to atmospheric density, pressure, and temperature profiles. We assumed unbiased errors as the occultation method is essentially self-calibrating and straight-line propagation of occulted signals as we focus on heights of 50–100 km, where refractive bending of the sensed radiation is negligible. Throughout the analysis the errors were characterized at each retrieval step by their mean profile, their covariance matrix and their probability density function (pdf. This furnishes, compared to a variance-only estimation, a much improved insight into the error propagation mechanism. We applied the procedure to a baseline analysis of the performance of a recently proposed solar UV occultation sensor (SMAS – Sun Monitor and Atmospheric Sounder and provide, using a reasonable exponential atmospheric model as background, results on error standard deviations and error correlation functions of density, pressure, and temperature profiles. Two different sensor photodiode assumptions are discussed, respectively, diamond diodes (DD with 0.03% and silicon diodes (SD with 0.1% (unattenuated intensity measurement noise at 10 Hz sampling rate. A factor-of-2 margin was applied to these noise values in order to roughly account for unmodeled cross section uncertainties. Within the entire height domain (50–100 km we find temperature to be retrieved to better than 0.3 K (DD / 1 K (SD accuracy, respectively, at 2 km height resolution. The results indicate that absorptive occultations acquired by a SMAS-type sensor could provide mesospheric profiles of fundamental variables such as temperature with

  11. Error analysis for mesospheric temperature profiling by absorptive occultation sensors

    Directory of Open Access Journals (Sweden)

    M. J. Rieder

    2001-01-01

    Full Text Available An error analysis for mesospheric profiles retrieved from absorptive occultation data has been performed, starting with realistic error assumptions as would apply to intensity data collected by available high-precision UV photodiode sensors. Propagation of statistical errors was investigated through the complete retrieval chain from measured intensity profiles to atmospheric density, pressure, and temperature profiles. We assumed unbiased errors as the occultation method is essentially self-calibrating and straight-line propagation of occulted signals as we focus on heights of 50–100 km, where refractive bending of the sensed radiation is negligible. Throughout the analysis the errors were characterized at each retrieval step by their mean profile, their covariance matrix and their probability density function (pdf. This furnishes, compared to a variance-only estimation, a much improved insight into the error propagation mechanism. We applied the procedure to a baseline analysis of the performance of a recently proposed solar UV occultation sensor (SMAS – Sun Monitor and Atmospheric Sounder and provide, using a reasonable exponential atmospheric model as background, results on error standard deviations and error correlation functions of density, pressure, and temperature profiles. Two different sensor photodiode assumptions are discussed, respectively, diamond diodes (DD with 0.03% and silicon diodes (SD with 0.1% (unattenuated intensity measurement noise at 10 Hz sampling rate. A factor-of-2 margin was applied to these noise values in order to roughly account for unmodeled cross section uncertainties. Within the entire height domain (50–100 km we find temperature to be retrieved to better than 0.3 K (DD / 1 K (SD accuracy, respectively, at 2 km height resolution. The results indicate that absorptive occultations acquired by a SMAS-type sensor could provide mesospheric profiles of fundamental variables such as temperature with

  12. Digital solar edge tracker for the Halogen Occultation Experiment

    Science.gov (United States)

    Mauldin, L. E., III; Moore, A. S.; Stump, C. W.; Mayo, L. S.

    1987-01-01

    The optical and electronic design of the Halogen Occultation Experiment (Haloe) elevation sun sensor is described. The Haloe instrument is a gas-correlation radiometer now being developed at NASA Langley for the Upper Atmosphere Research Satellite. The system uses a Galilean telescope to form a solar image on a linear silicon photodiode array. The array is a self-scanned monolithic CCD. The addresses of both solar edges imaged on the array are used by the control/pointing system to scan the Haloe science instantaneous field of view (IFOV) across the vertical solar diameter during instrument calibration and then to maintain the science IFOV 4 arcmin below the top edge during the science data occultation event. Vertical resolution of 16 arcsec and a radiometric dynamic range of 100 are achieved at the 700-nm operating wavelength. The design provides for loss of individual photodiode elements without loss of angular tracking capability.

  13. Sensitivity of GPS occultation to the stratopause height

    DEFF Research Database (Denmark)

    Schrøder, Thomas Morville; Ao, Chi; de la Torre Juárez, Manuel

    2007-01-01

    We scrutinize temperature profiles collected with radio occultation measurement for an imprint of the stratopause. In the retrieval step that integrates bending angle data to atmospheric refractivity, the falloff toward infinite altitude is constrained in a boundary condition with statistical opt...... rate, not isothermal conditions. Keeping the model seed for temperature conversion to subsequent retrieval steps eliminates external information from the deconvolved refractivity. It will help argue for radio occultation as independent vehicle for climate monitoring....... height gradient. On the basis of noise free simulation using a climatology covering all latitudes, seasons, and hours and on the basis of validation against data collected with weather balloons, laser imaging, and limb sounding, we find that adaptation to the fluctuating stratopause is crucial...

  14. Speech detection in noise and spatial unmasking in children with simultaneous versus sequential bilateral cochlear implants.

    Science.gov (United States)

    Chadha, Neil K; Papsin, Blake C; Jiwani, Salima; Gordon, Karen A

    2011-09-01

    To measure speech detection in noise performance for children with bilateral cochlear implants (BiCI), to compare performance in children with simultaneous implant versus those with sequential implant, and to compare performance to normal-hearing children. Prospective cohort study. Tertiary academic pediatric center. Children with early-onset bilateral deafness and 2-year BiCI experience, comprising the "sequential" group (>2 yr interimplantation delay, n = 12) and "simultaneous group" (no interimplantation delay, n = 10) and normal-hearing controls (n = 8). Thresholds to speech detection (at 0-degree azimuth) were measured with noise at 0-degree azimuth or ± 90-degree azimuth. Spatial unmasking (SU) as the noise condition changed from 0-degree azimuth to ± 90-degree azimuth and binaural summation advantage (BSA) of 2 over 1 CI. Speech detection in noise was significantly poorer than controls for both BiCI groups (p simultaneous group approached levels found in normal controls (7.2 ± 0.6 versus 8.6 ± 0.6 dB, p > 0.05) and was significantly better than that in the sequential group (3.9 ± 0.4 dB, p simultaneous group but, in the sequential group, was significantly better when noise was moved to the second rather than the first implanted ear (4.8 ± 0.5 versus 3.0 ± 0.4 dB, p sequential group's second rather than first CI. Children with simultaneously implanted BiCI demonstrated an advantage over children with sequential implant by using spatial cues to improve speech detection in noise.

  15. Modeling Sluggishness in Binaural Unmasking of Speech for Maskers With Time-Varying Interaural Phase Differences.

    Science.gov (United States)

    Hauth, Christopher F; Brand, Thomas

    2018-01-01

    In studies investigating binaural processing in human listeners, relatively long and task-dependent time constants of a binaural window ranging from 10 ms to 250 ms have been observed. Such time constants are often thought to reflect "binaural sluggishness." In this study, the effect of binaural sluggishness on binaural unmasking of speech in stationary speech-shaped noise is investigated in 10 listeners with normal hearing. In order to design a masking signal with temporally varying binaural cues, the interaural phase difference of the noise was modulated sinusoidally with frequencies ranging from 0.25 Hz to 64 Hz. The lowest, that is the best, speech reception thresholds (SRTs) were observed for the lowest modulation frequency. SRTs increased with increasing modulation frequency up to 4 Hz. For higher modulation frequencies, SRTs remained constant in the range of 1 dB to 1.5 dB below the SRT determined in the diotic situation. The outcome of the experiment was simulated using a short-term binaural speech intelligibility model, which combines an equalization-cancellation (EC) model with the speech intelligibility index. This model segments the incoming signal into 23.2-ms time frames in order to predict release from masking in modulated noises. In order to predict the results from this study, the model required a further time constant applied to the EC mechanism representing binaural sluggishness. The best agreement with perceptual data was achieved using a temporal window of 200 ms in the EC mechanism.

  16. Using sound to unmask losses disguised as wins in multiline slot machines.

    Science.gov (United States)

    Dixon, Mike J; Collins, Karen; Harrigan, Kevin A; Graydon, Candice; Fugelsang, Jonathan A

    2015-03-01

    Losses disguised as wins (LDWs) are slot machine outcomes where participants bet on multiple lines and win back less than their wager. Despite losing money, the machine celebrates these outcomes with reinforcing sights and sounds. Here, we sought to show that psychophysically and psychologically, participants treat LDWs as wins, but that we could expose LDWs as losses by using negative sounds as feedback. 157 participants were allocated into one of three conditions: a standard sound condition where LDWs, despite being losses, are paired with winning sights and sounds; a silent condition, where LDWs are paired with silence; and a negative sound condition where LDWs and regular losses are both followed by a negative sound. After viewing a paytable, participants conducted 300 spins on a slot machine simulator while heart rate deceleration (HRD) and skin conductance responses (SCRs) were monitored. Participants were then shown 20 different spin outcomes including LDWs and asked whether they had won or lost on that outcome. Participants then estimated on how many spins (out of 300) they won more than they wagered. SCRs were similar for losses and LDWs (both smaller than actual wins). HRD, however, was steeper for both wins and LDWs, compared to losses. In the standard condition, a majority of participants (mis)categorized LDWs as wins, and significantly overestimated the number of times they actually won. In the negative sound condition, this pattern was reversed; most participants correctly categorized LDWs as losses, and they gave high-fidelity win estimates. We conclude that participants both think and physiologically react to LDWs as though they are wins, a miscategorization that misleads them to think that they are winning more often than they actually are. Sound can be used to effectively prevent this misconception and unmask the disguise of LDWs.

  17. Unmasking of complements using proteinase-K in formalin fixed paraffin embedded renal biopsies

    Directory of Open Access Journals (Sweden)

    R Nada

    2016-01-01

    Full Text Available Renal biopsy interpretation requires histopathology, direct immunofluorescence (DIF and electron microscopy. Formalin-fixed, paraffin-embedded tissue (FFPE sent for light microscopy can be used for DIF after antigen retrieval. However, complement staining has not been satisfactory. We standardized DIF using proteinase-K for antigen retrieval in FFPE renal biopsies. A pilot study was conducted on known cases of membranous glomerulonephritis (MGN, membranoproliferative type-1 (MPGN-1, immunoglobulin A nephropathy (IgAN, and anti-glomerular basement disease (anti-GBM. Immunofluorescence panel included fluorescein isothiocyanate (FITC conjugated IgG, IgA, IgM, complements (C3 and C1q, light chains (kappa, lambda and fibrinogen antibodies. After standardization of the technique, 75 renal biopsies and 43 autopsies cases were stained. Out of 43 autopsy cases, immune-complex mediated glomerulonephritis (GN was confirmed in 18 cases (Lupus nephritis-11, IgAN-6, MGN-1, complement-mediated dense deposit disease (DDD-1 and monoclonal diseases in 4 cases (amyloidosis-3, cast nephropathy-1. Immune-mediated injury was excluded in 17 cases (focal segmental glomerulosclerosis -3, crescentic GN-6 [pauci-immune-3, anti-GBM-3], thrombotic microangiopathy-5, atherosclerosis-3. Renal biopsies (n-75 where inadequate or no frozen sample was available; this technique classified 52 mesangiocapillary pattern as MPGN type-1-46, DDD-2 and (C3GN-4. Others were diagnosed as IgAN-3, lupus nephritis-2, MGN-4, diffuse proliferative glomerulonephritis (DPGN-1, Non-IC crescentic GN-1, monoclonal diseases-3. In nine cases, DIF on FFPE tissue could not help in making diagnosis. Proteinase-K enzymatic digestion of FFPE renal biopsies can unmask complements (both C3 and C1q in immune-complexes mediated and complement-mediated diseases. This method showed good results on autopsy tissues archived for as long as 15 years.

  18. Dusty Dwarfs Galaxies Occulting A Bright Background Spiral

    Science.gov (United States)

    Holwerda, Benne

    2017-08-01

    The role of dust in shaping the spectral energy distributions of low mass disk galaxies remains poorly understood. Recent results from the Herschel Space Observatory imply that dwarf galaxies contain large amounts of cool (T 20K) dust, coupled with very modest optical extinctions. These seemingly contradictory conclusions may be resolved if dwarfs harbor a variety of dust geometries, e.g., dust at larger galactocentric radii or in quiescent dark clumps. We propose HST observations of six truly occulting dwarf galaxies drawn from the Galaxy Zoo catalog of silhouetted galaxy pairs. Confirmed, true occulting dwarfs are rare as most low-mass disks in overlap are either close satellites or do not have a confirmed redshift. Dwarf occulters are the key to determining the spatial extent of dust, the small scale structure introduced by turbulence, and the prevailing dust attenuation law. The recent spectroscopic confirmation of bona-fide low mass occulting dwarfs offers an opportunity to map dust in these with HST. What is the role of dust in the SED of these dwarf disk galaxies? With shorter feedback scales, how does star-formation affect their morphology and dust composition, as revealed from their attenuation curve? The resolution of HST allows us to map the dust disks down to the fine scale structure of molecular clouds and multi-wavelength imaging maps the attenuation curve and hence dust composition in these disks. We therefore ask for 2 orbits on each of 6 dwarf galaxies in F275W, F475W, F606W, F814W and F125W to map dust from UV to NIR to constrain the attenuation curve.

  19. A variational regularization of Abel transform for GPS radio occultation

    OpenAIRE

    T.-K. Wee

    2018-01-01

    In the Global Positioning System (GPS) radio occultation (RO) technique, the inverse Abel transform of measured bending angle (Abel inversion, hereafter AI) is the standard means of deriving the refractivity. While concise and straightforward to apply, the AI accumulates and propagates the measurement error downward. The measurement error propagation is detrimental to the refractivity in lower altitudes. In particular, it builds up negative refractivity bias in the tropical ...

  20. [Occult pneumothorax: Does it take drain before elective surgery?].

    Science.gov (United States)

    Bensghir, M; Moutaoukil, M; Meziane, M; Jaafari, A; Hemmaoui, B; Haimeur, C

    2016-08-01

    Pneumothorax occult is defined by the presence of a non-visible to standard asymptomatic pneumothorax and pulmonary diagnosed only by X-ray computed tomography. The presence of this type of pneumothorax before planned surgery is a rare situation. What to do remains non-consensual. Through two clinic cases and a literature review, the authors discuss the modalities of management of this entity. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  1. Implementation of immunochemical faecal occult blood test in general practice

    DEFF Research Database (Denmark)

    Juul, Jakob Søgaard; Bro, Flemming; Hornung, Nete

    2016-01-01

    anvendelsen af immunochemical faecal occult blood test (iFOBT) i almen praksis. iFOBT detekterer humant globin i fæces og indikerer gastrointestinal blødning. Studiet udgør en del af et ph.d.-studie, der bidrager med ny viden til at optimere udredningen af patienter med tarmkræft. Der er et stort behov...

  2. [Results of conservative treatment in patients with occult pneumothorax].

    Science.gov (United States)

    Llaquet Bayo, Heura; Montmany Vioque, Sandra; Rebasa, Pere; Navarro Soto, Salvador

    2016-04-01

    An occult pneumothorax is found in 2-15% trauma patients. Observation (without tube thoracostomy) in these patients presents still some controversies in the clinical practice. The objective of the study is to evaluate the efficacy and the adverse effects when observation is performed. A retrospective observational study was undertaken in our center (university hospital level II). Data was obtained from a database with prospective registration. A total of 1087 trauma patients admitted in the intensive care unit from 2006 to 2013 were included. In this period, 126 patients with occult pneumothorax were identified, 73 patients (58%) underwent immediate tube thoracostomy and 53 patients (42%) were observed. Nine patients (12%) failed observation and required tube thoracostomy for pneumothorax progression or hemothorax. No patient developed a tension pneumothorax or experienced another adverse event related to the absence of tube thoracostomy. Of the observed patients 16 were under positive pressure ventilation, in this group 3 patients (19%) failed observation. There were no differences in mortality, hospital length of stay or intensive care length of stay between the observed and non-observed group. Observation is a safe treatment in occult pneumothorax, even in pressure positive ventilated patients. Copyright © 2014 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  3. Lunar occultation observation of μ Sgr: A progress report

    Energy Technology Data Exchange (ETDEWEB)

    Jatmiko, A. T. P. [Bosscha Observatory, Institut Teknologi Bandung (Indonesia); Puannandra, G. P.; Hapsari, R. D.; Putri, R. A.; Arifin, Z. M.; Haans, G. K.; Hadiputrawan, I. P. W. [Bosscha Observatory, Institut Teknologi Bandung, Indonesia and Astronomy Study Program, Institut Teknologi Bandung (Indonesia)

    2014-03-24

    Lunar Occultation (LO) is an event where limb of the Moon passing over a particular heavenly bodies such as stars, asteroids, or planets. In other words, during the event, stars, asteroids and planets are occulted by the Moon. When occulted objects contact the lunar limb, there will be a diffraction fringe(s) which can be measured photometrically, until the signal vanishes into noise. This event will give us a valuable information about binarities (of stars) and/or angular diameters estimation (of stars, planets, asteroids) in milliarcsecond resolution, by fitting with theoretical LO pattern. CCDs are common for LO observation because of its fast read out, and recently are developed for sub-meter class telescope. In this paper, our LO observation attempt of μ Sgr and its progress report are presented. The observation was conducted on July 30{sup th}, 2012 at Bosscha Observatory, Indonesia, using 45cm f/12 GOTO telescope combined with ST-9 XE CCD camera and Bessel B filter. We used drift-scan method to obtain light curve of the star as it was disappearing behind Moon's dark limb. Our goal is to detect binarity (or multiplicity) of this particular object.

  4. Unmasking of tracheomalacia following short-term mechanical ventilation in a patient of adult respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Harihar V Hegde

    2012-01-01

    Full Text Available Patients with chronic obstructive pulmonary disease (COPD are susceptible to airway malacia, which may be unmasked following mechanical ventilation or tracheostomy decannulation. Dynamic imaging of central airways, a non-invasive test as effective as bronchoscopy to diagnose airway malacia, has increased the recognition of this disorder. We describe a 70-year-old woman admitted with adult respiratory distress syndrome. She had cardiorespiratory arrest on admission, from which she was successfully resuscitated. She had obesity, hypertension, diabetes mellitus, recurrent ventricular tachycardia, sarcoidosis with interstitial lung disease and COPD. She received short-term (18 days mechanical ventilation with tracheostomy and developed respiratory distress following tracheostomy decannulation.

  5. Stress !!!

    NARCIS (Netherlands)

    Fledderus, M.

    2012-01-01

    Twee op de vijf UT-studenten hebben last van ernstige studiestress, zo erg zelfs dat het ze in hun privéleven belemmert. Die cijfers komen overeen met het landelijk beeld van stress onder studenten. Samen met 14 andere universiteits- en hogeschoolbladen enquêteerde UT Nieuws bijna 5500 studenten.

  6. Developing an Optical Lunar Occultation Measurement Reduction System for Observations at Kaau Observatory

    Science.gov (United States)

    Malawi, Abdulrahman A.

    2013-06-01

    We present here a detailed explanation of the reduction method that we use to determine the angular diameters of the stars occulted by the dark limb of the moon. This is a main part of the lunar occultation observation program running at King Abdul Aziz University observatory since late 1993. The process is based on the least square model fitting method of analyzing occultation data, first introduced by Nather et al. (Astron. J. 75:963, 1970).

  7. Lunar occultation of Saturn. IV - Astrometric results from observations of the satellites

    Science.gov (United States)

    Dunham, D. W.; Elliot, J. L.

    1978-01-01

    The method of determining local lunar limb slopes, and the consequent time scale needed for diameter studies, from accurate occultation timings at two nearby telescopes is described. Results for photoelectric observations made at Mauna Kea Observatory during the occultation of Saturn's satellites on March 30, 1974, are discussed. Analysis of all observations of occultations of Saturn's satellites during 1974 indicates possible errors in the ephemerides of Saturn and its satellites.

  8. Diagnostic accuracy of oblique chest radiograph for occult pneumothorax: comparison with ultrasonography

    OpenAIRE

    Matsumoto, Shokei; Sekine, Kazuhiko; Funabiki, Tomohiro; Orita, Tomohiko; Shimizu, Masayuki; Hayashida, Kei; Kazamaki, Taku; Suzuki, Tatsuya; Kishikawa, Masanobu; Yamazaki, Motoyasu; Kitano, Mitsuhide

    2016-01-01

    Backgraound An occult pneumothorax is a pneumothorax that is not seen on a supine chest X-ray but is detected by computed tomography scanning. However, critical patients are difficult to transport to the computed tomography suite. We previously reported a method to detect occult pneumothorax using oblique chest radiography (OXR). Several authors have also reported that ultrasonography is an effective technique for detecting occult pneumothorax. The aim of this study was to evaluate the useful...

  9. Immune Reconstitution Inflammatory Syndrome Unmasking or Worsening AIDS-Related Progressive Multifocal Leukoencephalopathy: A Literature Review

    Directory of Open Access Journals (Sweden)

    Anna Fournier

    2017-05-01

    Full Text Available Incidence of progressive multifocal leukoencephalopathy (PML in HIV-infected patients has declined in the combined antiretroviral therapy (cART era although a growing number of acquired immunodeficiency syndrome (AIDS-related PML-immune reconstitution inflammatory syndromes (PML-IRIS have been published during the same period. Therapeutic management of PML-IRIS is not consensual and mainly relies on corticosteroids. Our main aim was, in addition to provide a thoughtful analysis of published PML-IRIS cases, to assess the benefit of corticosteroids in the management of PML-IRIS, focusing on confirmed cases. We performed a literature review of the 46 confirmed cases of PML-IRIS cases occurring in HIV-infected patients from 1998 to September 2016 (21 unmasking and 25 paradoxical PML-IRIS. AIDS-related PML-IRIS patients were mostly men (sex ratio 4/1 with a median age of 40.5 years (range 12–66. Median CD4 T cell count before cART and at PML-IRIS onset was 45/μl (0–301 and 101/μl (20–610, respectively. After cART initiation, PML-IRIS occurred within a median timescale of 38 days (18–120. Clinical signs were motor deficits (69%, speech disorders (36%, cognitive disorders (33%, cerebellar ataxia (28%, and visual disturbances (23%. Brain MRI revealed hyperintense areas on T2-weighted sequences and FLAIR images (76% and suggestive contrast enhancement (87%. PCR for John Cunningham virus (JCV in cerebrospinal fluid (CSF was positive in only 84% of cases; however, when performed, brain biopsy confirmed diagnosis of PML in 90% of cases and demonstrated histological signs of IRIS in 95% of cases. Clinical worsening related to PML-IRIS and leading to death was observed in 28% of cases. Corticosteroids were prescribed in 63% of cases and maraviroc in one case. Statistical analysis failed to demonstrate significant benefit from steroid treatment, despite spectacular improvement in certain cases. Diagnosis of PML-IRIS should be considered in HIV

  10. Immune Reconstitution Inflammatory Syndrome Unmasking or Worsening AIDS-Related Progressive Multifocal Leukoencephalopathy: A Literature Review.

    Science.gov (United States)

    Fournier, Anna; Martin-Blondel, Guillaume; Lechapt-Zalcman, Emmanuèle; Dina, Julia; Kazemi, Apolline; Verdon, Renaud; Mortier, Emmanuel; de La Blanchardière, Arnaud

    2017-01-01

    Incidence of progressive multifocal leukoencephalopathy (PML) in HIV-infected patients has declined in the combined antiretroviral therapy (cART) era although a growing number of acquired immunodeficiency syndrome (AIDS)-related PML-immune reconstitution inflammatory syndromes (PML-IRIS) have been published during the same period. Therapeutic management of PML-IRIS is not consensual and mainly relies on corticosteroids. Our main aim was, in addition to provide a thoughtful analysis of published PML-IRIS cases, to assess the benefit of corticosteroids in the management of PML-IRIS, focusing on confirmed cases. We performed a literature review of the 46 confirmed cases of PML-IRIS cases occurring in HIV-infected patients from 1998 to September 2016 (21 unmasking and 25 paradoxical PML-IRIS). AIDS-related PML-IRIS patients were mostly men (sex ratio 4/1) with a median age of 40.5 years (range 12-66). Median CD4 T cell count before cART and at PML-IRIS onset was 45/μl (0-301) and 101/μl (20-610), respectively. After cART initiation, PML-IRIS occurred within a median timescale of 38 days (18-120). Clinical signs were motor deficits (69%), speech disorders (36%), cognitive disorders (33%), cerebellar ataxia (28%), and visual disturbances (23%). Brain MRI revealed hyperintense areas on T2-weighted sequences and FLAIR images (76%) and suggestive contrast enhancement (87%). PCR for John Cunningham virus (JCV) in cerebrospinal fluid (CSF) was positive in only 84% of cases; however, when performed, brain biopsy confirmed diagnosis of PML in 90% of cases and demonstrated histological signs of IRIS in 95% of cases. Clinical worsening related to PML-IRIS and leading to death was observed in 28% of cases. Corticosteroids were prescribed in 63% of cases and maraviroc in one case. Statistical analysis failed to demonstrate significant benefit from steroid treatment, despite spectacular improvement in certain cases. Diagnosis of PML-IRIS should be considered in HIV

  11. Stress.

    Science.gov (United States)

    Chambers, David W

    2008-01-01

    We all experience stress as a regular, and sometimes damaging and sometimes useful, part of our daily lives. In our normal ups and downs, we have our share of exhaustion, despondency, and outrage--matched with their corresponding positive moods. But burnout and workaholism are different. They are chronic, dysfunctional, self-reinforcing, life-shortening habits. Dentists, nurses, teachers, ministers, social workers, and entertainers are especially susceptible to burnout; not because they are hard-working professionals (they tend to be), but because they are caring perfectionists who share control for the success of what they do with others and perform under the scrutiny of their colleagues (they tend to). Workaholics are also trapped in self-sealing cycles, but the elements are ever-receding visions of control and using constant activity as a barrier against facing reality. This essay explores the symptoms, mechanisms, causes, and successful coping strategies for burnout and workaholism. It also takes a look at the general stress response on the physiological level and at some of the damage American society inflicts on itself.

  12. [Management of occult malformations at the lateral skull base].

    Science.gov (United States)

    Bryson, E; Draf, W; Hofmann, E; Bockmühl, U

    2005-12-01

    Occult malformations of the lateral skull base are rare anomalies, but can cause severe complications such as recurrent meningitis. Therefore, they need to be precisely delineated and sufficient surgical closure is mandatory. Between 1986 and 2004 twenty patients (10 children and 10 adults) with occult malformations at the lateral skull base were treated surgically at the ENT-Department of the Hospital Fulda gAG. Of these 3 Mondini-malformations, 11 defects of the tegmen tympani or the mastoidal roof, 2 dural lesions to the posterior fossa and 4 malformations within the pyramidal apex have been found. Four patients have had multiple anomalies. Routing symptom was in all cases at least one previous meningitis. Radiological diagnostics included high-resolution computed tomography (CT) and magnetic resonance imaging (MRI) as well as CT- or MR-cisternography. Depending on type and localisation of the defect the following surgical algorithm was carried out: The trans-mastoidal approach was used in all cases of Mondini-malformation (including obliteration of the ear), in case of lesions to the posterior fossa as well as partly in anomalies at the tegmen tympani and mastoidal roof, respectively. Defects of the pyramidal apex should be explored via the trans-mastoidal way if the lesion is located caudally to the inner auditory canal (IAC), whereas the trans-temporal approach should be used if the lesion is situated ventral to the IAC and dorso-medially to the internal carotid artery (ICA). The trans-temporal approach was also performed in large defects of the tegmen tympani and mastoidal roof as well as in recurrences. In all cases of recurrent meningitis caused by agents of the upper airway tract the basic principle should be to search for occult skull base malformations radiologically as well as by sodium fluorescein endoscopy as long as the anomaly is detected.

  13. A 2017 stellar occultation by Orcus/Vanth

    Science.gov (United States)

    Sickafoose, Amanda A.; Bosh, Amanda S.; Levine, Stephen; Zuluaga, Carlos A.; Genade, Anja; Schindler, Karsten; Lister, Tim; Person, Michael J.

    2017-10-01

    (90482) Orcus is a large trans-Neptunian object (TNO) of diameter ~900 km, located in the 3:2 orbital resonance with Neptune. This plutino has a satellite, Vanth, approximately 280 km in diameter. Vanth orbits roughly 9000 km from Orcus in a ~9.5-day period. This system is particularly interesting, as Orcus falls between the small, spectrally-bland TNOs and the large TNOs having spectra rich in volatile features, while Vanth might have resulted from either collision or capture.A stellar occultation by Orcus was predicted to occur on 07 March 2017. Observations were made from five sites: the 0.6-m Astronomical Telescope of the University of Stuttgart (ATUS) at Sierra Remote Observatories (SRO), California; Las Cumbres Observatory’s 1-m telescope (ELP) at McDonald Observatory, Fort Davis, Texas; NASA’s 3-m InfraRed Telescope Facility (IRTF) on Mauna Kea, Hawaii; the 4.1-m Southern Astrophysical Research telescope (SOAR) on Cerro Pachón, Chile; and the 0.6-m Southeastern Association for Research in Astronomy telescope (SARA-CT) at Cerro Tololo, Chile. High-speed, visible-wavelength images were taken at all sites, in addition to simultaneous K-band images at the IRTF. A solid-body occultation was observed at both ELP and the IRTF. Offset midtimes and incompatible light ratios suggest that two different stars were occulted by two different bodies, likely Orcus and Vanth. See Bosh et al. this conference for details of the astrometry for the event. Here, we present results from the observations, including light curves, size and albedo estimates, and upper limits on a possible atmosphere.

  14. External occulter edge scattering control using metamaterials for exoplanet detection

    Science.gov (United States)

    Bendek, Eduardo A.; Sirbu, Dan; Liu, Zhaowei; Martin, Stefan; Lu, Dylan

    2015-09-01

    Direct imaging of earth-like exoplanets in the Habitable Zone of sun-like stars requires image contrast of ~10^10 at angular separations of around a hundred milliarcseconds. One approach for achieving this performance is to fly a starshade at a long distance in front of the telescope, shading the telescope from the direct starlight, but allowing planets around the star to be seen. The starshade is positioned so that sunlight falls on the surface away from the telescope, so the sun does not directly illuminate it. However, sunlight scattered from the starshade edge can enter the telescope, raising the background light level and potentially preventing the starshade from delivering the required contrast. As a result, starshade edge design has been identified as one of the highest priority technology gaps for external occulter missions in the NASAs Exoplanet Exploration Program Technology Plan 2013. To reduce the sunlight edge scatter to an acceptable level, the edge Radius Of Curvature (ROC) should be 1μm or less (commercial razor blades have ROC of a few hundred nanometer). This poses a challenging manufacturing requirement and may make the occulter difficult to handle. In this paper we propose an alternative approach to controlling the edge scattering by applying a flexible metamaterial to the occulter edge. Metamaterials are artificially structured materials, which have been designed to display properties not found in natural materials. Metamaterials can be designed to direct the scatter at planned incident angles away from the space telescope, thereby directly decreasing the contaminating background light. Reduction of the background light translates into shorter integration time to characterize a target planet and therefore improves the efficiency of the observations. As an additional benefit, metamaterials also have potential to produce increased tolerance to edge defects.

  15. Multiple surface antigen mutations in five blood donors with occult hepatitis B virus infection

    NARCIS (Netherlands)

    Zaaijer, H. L.; Torres, P.; Ontañón, A.; Ponte, L. González; Koppelman, M. H. G. M.; Lelie, P. N.; Hemert, F. J. van; Boot, H. J.

    2008-01-01

    Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA while the HBV surface antigen (HBsAg) remains undetectable. The HBV genomes in five asymptomatic blood donors with occult HBV infection and low viremia ( <10 to 1,000 HBV DNA copies/mL, genotype D) were studied. An

  16. Trio of Stellar Occultations by Pluto One Year Prior to New Horizons’ Arrival

    Science.gov (United States)

    2016-04-02

    stellar signal, both with 20 s exposures with our frame-transfer Portable Occultation, Eclipse, and Transit System. Since Pluto had a geocentric velocity...and for New Horizons’s 2015 approach . For the July 31 event, though for our atmospheric studies we are glad to have detected the occultation of this

  17. Combined parathyroid adenoma and an occult papillary carcinoma

    International Nuclear Information System (INIS)

    Meshikhes, Abdul-Wahid N.; Al-Saihati, Basima A.; Butt, Mohammad S.

    2004-01-01

    Although the pathological association of thyroid and parathyroid disease is common, the association of both parathyroid adenoma and thyroid cancer is rare. We report here a case of a 45-year-old saudi women who diagnosed to have primary hyperparathyrodism due to single parathyroid adenoma as confirmed biochemically and radiologically. At operation, the adenoma was found to be an intrathyroid and therefore a thyroid lobectomy was performed. Histology of the excised lobe revealed in addition to the intrathyroid parathyroid adenoma a concurrent occult thyroid papillary carcinoma. The interesting association is discussed based on a literature review. (author)

  18. Laser fluorescence bronchoscope for localization of occult lung tumors

    International Nuclear Information System (INIS)

    Profio, A.E.; Doiron, D.R.; King, E.G.

    1979-01-01

    A system for imaging occult bronchogenic carcinoma by the fluorescence of previously-injected, tumor-specific compound hematoporphyrin-derivative has been assembled and successfully used to locate a tumor l mm thick. The violet excitation source is a krypton ion laser coupled to fused quartz fiber light conductor. An electrostatic image intensifier attached to a standard flexible fiberoptic bronchoscope provides a bright image even at relatively low irradiance. A red secondary filter rejects most reflected background and autofluorescence. Sensitivity and contrast capability of the system should permit detection of a tumor less than 0.1 mm thick

  19. Occult microscopic endometriosis: undetectable by laparoscopy in normal peritoneum.

    Science.gov (United States)

    Khan, Khaleque Newaz; Fujishita, Akira; Kitajima, Michio; Hiraki, Koichi; Nakashima, Masahiro; Masuzaki, Hideaki

    2014-03-01

    Is there any occurrence of hidden (occult) endometriotic lesions in normal peritoneum of women with and without visible endometriosis? We detected a slightly higher occurrence of occult microscopic endometriosis (OME) in normal peritoneum of women with visible endometriosis than in control women. Based on a small number of cases, the concept of invisible microscopic endometriosis in visually normal peritoneum has been reported for more than a decade but there is controversy regarding their tissue activity and clinical significance. This case-controlled research study was conducted with prospectively collected normal peritoneal samples from 151 women with and 62 women without visible endometriosis. Normal peritoneal biopsy specimens from different pelvic sites of were collected during laparoscopy. A histological search of all peritoneal biopsy specimens for the detection of invisible endometriosis was done by immunoreaction to Ber-EP4 (epithelial cell marker), CD10 (stromal cell marker) and Calretinin (mesothelial cell marker). Tissue expression of estrogen/progesterone receptors (ER/PR) and cell proliferation marker, Ki-67, was performed by immunohistochemistry to identify tissue activity. Three different patterns of OME were detected based on (I) the presence of typical gland/stroma, (II) reactive hyperplastic change of endometrioid epithelial cells with surrounding stroma and (III) single-layered epithelium-lined cystic lesions with surrounding stroma. A higher tendency toward the occurrence of OME was found in women with visible endometriosis (15.2%, 23/151) compared with control women (6.4%, 4/62) (P = 0.06, χ(2) test). The epithelial cells and/or stromal cells of OME lesions were immunoreactive to Ber-EP4 and CD10 but not reactive to Calretinin. ER and PR expression was observed in all patterns of OME lesions. Ki-67 index was significantly higher in pattern I/II OME lesions than in pattern III OME lesions (Pendometriosis due to the presence of adhesions in

  20. Significance of mammographic signs in clinically occult disease

    Energy Technology Data Exchange (ETDEWEB)

    Waal, J.C. de; Steil, B.; Baltzer, J.; Vaillant, W.; Zander, J.

    1987-10-01

    The significance of various radiographic signs in 183 patients with clinically occult breast disease is described. 30.6% hat a carcinoma of the breast or a carcinoma in situ. The radiological features have varying predictive values and there is variation in the incidence of lymph node metastases. It is considered useful to classify the radiological appearances under the headings of round foci, star-shaped opacities, diffuse opacities, opacities with calcification and groups of micro-calcification. Despite the early diagnosis, 24% of patients already had lymph node metastases.

  1. Occult lung malignancy presenting with finger pain: a case report

    Directory of Open Access Journals (Sweden)

    Embley Matthew A

    2008-12-01

    Full Text Available Abstract Introduction Lung cancer is currently one of the most common malignancies in the world. Early detection is an important prognostic factor. Unfortunately, initial symptoms may be vague and a substantial proportion of cases present with the effects of metastases. Case presentation We discuss a case of occult lung malignancy in a 61-year-old man. The only symptom at presentation was pain in the right ring finger due to metastasis from the lung primary. Conclusion This case highlights the need for vigilance when a patient presents with unusual or unexplained symptoms, especially if they have known risk factors for cancer.

  2. James Webb Space Telescope Observations of Stellar Occultations by Solar System Bodies and Rings

    Science.gov (United States)

    Santos-Sanz, P.; French, R. G.; Pinilla-Alonso, N.; Stansberry, J.; Lin, Z-Y.; Zhang, Z-W.; Vilenius, E.; Mueller, Th.; Ortiz, J. L.; Braga-Ribas, F.; hide

    2016-01-01

    In this paper, we investigate the opportunities provided by the James Webb Space Telescope (JWST) for significant scientific advances in the study of Solar System bodies and rings using stellar occultations. The strengths and weaknesses of the stellar occultation technique are evaluated in light of JWST's unique capabilities. We identify several possible JWST occultation events by minor bodies and rings and evaluate their potential scientific value. These predictions depend critically on accurate a priori knowledge of the orbit of JWST near the Sun–Earth Lagrange point 2 (L2). We also explore the possibility of serendipitous stellar occultations by very small minor bodies as a byproduct of other JWST observing programs. Finally, to optimize the potential scientific return of stellar occultation observations, we identify several characteristics of JWST's orbit and instrumentation that should be taken into account during JWST's development.

  3. Wave propagation simulation of radio occultations based on ECMWF refractivity profiles

    DEFF Research Database (Denmark)

    von Benzon, Hans-Henrik; Høeg, Per

    2015-01-01

    This paper describes a complete radio occultation simulation environment, including realistic refractivity profiles, wave propagation modeling, instrument modeling, and bending angle retrieval. The wave propagator is used to simulate radio occultation measurements. The radio waves are propagated...... of radio occultations. The output from the wave propagator simulator is used as input to a Full Spectrum Inversion retrieval module which calculates geophysical parameters. These parameters can be compared to the ECMWF atmospheric profiles. The comparison can be used to reveal system errors and get...... a better understanding of the physics. The wave propagation simulations will in this paper also be compared to real measurements. These radio occultations have been exposed to the same atmospheric conditions as the radio occultations simulated by the wave propagator. This comparison reveals that precise...

  4. PREVALENCE OF OCCULT DEPRESSION IN ELDERLY WITH CHRONIC CO - MORBIDS

    Directory of Open Access Journals (Sweden)

    Sachin

    2015-02-01

    Full Text Available BACKGROUND: Growth in elderly population has led to an increase in age related diseases and mainly depression which is affecting the quality of life. Depression is more prevalent amongst elderly individuals with medical illnesses and emerging public health problem leading to increased morbidity and disability worldwide. AIMS AND OBJE CTIVES: To assess the prevalence of occult depression in elderly patients with chronic co - morbid medical conditions. MATERIALS AND METHODS: It was a cross - sectional study conducted in tertiary hospital. Total 100 elderly patients with underlying chronic me dical illnesses were included. Depression in study population was assessed by geriatric depression scale and analyzed. RESULT: Out of 100 patients 23(23% had depression. Females 12/39(30.76% were affected more than males 11/61 (18.03%. Depression was mo re prevalent among patients with 3 or more co - morbid conditions (45.4% as compared to <3 (11.9%. CONCLUSION: Elderly patients with multiple chronic medical illnesses may have associated occult depression. Screening of these patients for depression couple d with appropriate psychiatric referral should be an integral part of Geriatric service

  5. Fluctuations of radio occultation signals in sounding the Earth's atmosphere

    Directory of Open Access Journals (Sweden)

    V. Kan

    2018-02-01

    Full Text Available We discuss the relationships that link the observed fluctuation spectra of the amplitude and phase of signals used for the radio occultation sounding of the Earth's atmosphere, with the spectra of atmospheric inhomogeneities. Our analysis employs the approximation of the phase screen and of weak fluctuations. We make our estimates for the following characteristic inhomogeneity types: (1 the isotropic Kolmogorov turbulence and (2 the anisotropic saturated internal gravity waves. We obtain the expressions for the variances of the amplitude and phase fluctuations of radio occultation signals as well as their estimates for the typical parameters of inhomogeneity models. From the GPS/MET observations, we evaluate the spectra of the amplitude and phase fluctuations in the altitude interval from 4 to 25 km in the middle and polar latitudes. As indicated by theoretical and experimental estimates, the main contribution into the radio signal fluctuations comes from the internal gravity waves. The influence of the Kolmogorov turbulence is negligible. We derive simple relationships that link the parameters of internal gravity waves and the statistical characteristics of the radio signal fluctuations. These results may serve as the basis for the global monitoring of the wave activity in the stratosphere and upper troposphere.

  6. Progress in turbulence detection via GNSS occultation data

    Directory of Open Access Journals (Sweden)

    L. B. Cornman

    2012-04-01

    Full Text Available The increased availability of radio occultation (RO data offers the ability to detect and study turbulence in the Earth's atmosphere. An analysis of how RO data can be used to determine the strength and location of turbulent regions is presented. This includes the derivation of a model for the power spectrum of the log-amplitude and phase fluctuations of the permittivity (or index of refraction field. The bulk of the paper is then concerned with the estimation of the model parameters. Parameter estimators are introduced and some of their statistical properties are studied. These estimators are then applied to simulated log-amplitude RO signals. This includes the analysis of global statistics derived from a large number of realizations, as well as case studies that illustrate various specific aspects of the problem. Improvements to the basic estimation methods are discussed, and their beneficial properties are illustrated. The estimation techniques are then applied to real occultation data. Only two cases are presented, but they illustrate some of the salient features inherent in real data.

  7. Influence of Ionospheric Weather on GNSS Radio Occultation Signals

    Science.gov (United States)

    Yue, X.; Schreiner, W. S.; Pedatella, N. M.; Kuo, Y. H.

    2016-12-01

    Transient loss of lock (LOL) is one of the key space weather effects on the Global Navigation Satellite System (GNSS). Based on the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) Global Positioning System (GPS) radio occultation (RO) observations during 2007-2011, we have analyzed the signal cycle slip (CS) occurrence comprehensively and its correlation to the ionospheric weather phenomena such as sporadic E (Es), equatorial F region irregularity (EFI), and the ionospheric equatorial ionization anomaly (EIA). The high vertical resolution of RO observations enables us to distinguish the CS resulting from different ionospheric layers clearly on a global scale. In the E layer, the CS is dominated by the Es occurrence, while in the F layer, the CS is mainly related to the EIA and EFI at low and equatorial latitudes. In the polar region, the CS is primarily related to polar cap electron density gradients. The overall average CS (> 6 cycles) occurrence is 23% per occultation, with the E (50-150 km) and F (150-600 km) layers contributing 8.3% and 14.7%, respectively. Awareness of the effect of the ionospheric weather on the CS of the low-Earth-orbit (LEO)-based GNSS signal could be beneficial to a variety of applications, including the LEO-based GNSS data processing and the corresponding hardware/firmware design.

  8. Occulting Light Concentrators in Liquid Scintillator Neutrino Detectors

    Science.gov (United States)

    Buizza Avanzini, Margherita; Cabrera, Anatael; Dusini, Stefano; Grassi, Marco; He, Miao; Wu, Wenjie

    2017-09-01

    The experimental efforts characterizing the era of precision neutrino physics revolve around collecting high-statistics neutrino samples and attaining an excellent energy and position resolution. Next generation liquid-based neutrino detectors, such as JUNO, HyperKamiokande, etc, share the use of a large target mass, and the need of pushing light collection to the edge for maximal calorimetric information. Achieving high light collection implies considerable costs, especially when considering detector masses of several kt. A traditional strategy to maximize the effective photo-coverage with the minimum number of PMTs relies on Light Concentrators (LC), such as Winston Cones. In this paper, the authors introduce a novel concept called Occulting Light Concentrators (OLC), whereby a traditional LC gets tailored to a conventional PMT, by taking into account its single-photoelectron collection efficiency profile and thus occulting the worst performing portion of the photocathode. Thus, the OLC shape optimization takes into account not only the optical interface of the PMT, but also the maximization of the PMT detection performances. The light collection uniformity across the detector is another advantage of the OLC system. By considering the case of JUNO, we will show OLC capabilities in terms of light collection and energy resolution.

  9. Image guidance improves localization of sonographically occult colorectal liver metastases

    Science.gov (United States)

    Leung, Universe; Simpson, Amber L.; Adams, Lauryn B.; Jarnagin, William R.; Miga, Michael I.; Kingham, T. Peter

    2015-03-01

    Assessing the therapeutic benefit of surgical navigation systems is a challenging problem in image-guided surgery. The exact clinical indications for patients that may benefit from these systems is not always clear, particularly for abdominal surgery where image-guidance systems have failed to take hold in the same way as orthopedic and neurosurgical applications. We report interim analysis of a prospective clinical trial for localizing small colorectal liver metastases using the Explorer system (Path Finder Technologies, Nashville, TN). Colorectal liver metastases are small lesions that can be difficult to identify with conventional intraoperative ultrasound due to echogeneity changes in the liver as a result of chemotherapy and other preoperative treatments. Interim analysis with eighteen patients shows that 9 of 15 (60%) of these occult lesions could be detected with image guidance. Image guidance changed intraoperative management in 3 (17%) cases. These results suggest that image guidance is a promising tool for localization of small occult liver metastases and that the indications for image-guided surgery are expanding.

  10. 'Trick', 'manipulation' and 'farce': Albert Moll's critique of occultism.

    Science.gov (United States)

    Wolffram, Heather

    2012-04-01

    In July 1925, the psychiatrist Albert Moll appeared before the district court in Berlin-Schöneberg charged with having defamed the medium Maria Vollhardt (alias Rudloff) in his 1924 book Der Spiritismus [Spiritism]. Supported by some of Berlin's most prominent occultists, the plaintiff--the medium's husband--argued that Moll's use of terms such as 'trick', 'manipulation' and 'farce' in reference to Vollhardt's phenomena had been libellous. In the three-part trial that followed, however, Moll's putative affront to the medium--of which he was eventually acquitted--was overshadowed, on the one hand, by a debate over the scientific status of parapsychology, and on the other, by the question of who--parapsychologists, occultists, psychiatrists or jurists--was entitled to claim epistemic authority over the occult. This paper will use the Rudloff-Moll trial as a means of examining Moll's critique of occultism, not only as it stood in the mid-1920s, but also as it had developed since the 1880s. It will also provide insight into the views of Germany's occultists and parapsychologists, who argued that their legitimate bid for scientific credibility was hindered by Dunkelmänner [obscurantists] such as Albert Moll.

  11. Advanced Electrocardiography Can Identify Occult Cardiomyopathy in Doberman Pinschers

    Science.gov (United States)

    Spiljak, M.; Petric, A. Domanjko; Wilberg, M.; Olsen, L. H.; Stepancic, A.; Schlegel, T. T.; Starc, V.

    2011-01-01

    Recently, multiple advanced resting electrocardiographic (A-ECG) techniques have improved the diagnostic value of short-duration ECG in detection of dilated cardiomyopathy (DCM) in humans. This study investigated whether 12-lead A-ECG recordings could accurately identify the occult phase of DCM in dogs. Short-duration (3-5 min) high-fidelity 12-lead ECG recordings were obtained from 31 privately-owned, clinically healthy Doberman Pinschers (5.4 +/- 1.7 years, 11/20 males/females). Dogs were divided into 2 groups: 1) 19 healthy dogs with normal echocardiographic M-mode measurements: left ventricular internal diameter in diastole (LVIDd . 47mm) and in systole (LVIDs . 38mm) and normal 24-hour ECG recordings (100 VPCs/24h; 1/12 dogs had only abnormal 24-hour ECG recordings (>100 VPCs/24h). ECG recordings were evaluated via custom software programs to calculate multiple parameters of high-frequency (HF) QRS ECG, heart rate variability, QT variability, waveform complexity and 3-D ECG. Student's t-tests determined 19 ECG parameters that were significantly different (P canine DCM as five selected ECG parameters can with reasonable accuracy identify occult DCM in Doberman Pinschers. Future extensive clinical studies need to clarify if 12-lead A-ECG could be useful as an additional screening test for canine DCM.

  12. Ex Luna Scientia: The Lunar Occultation Explorer (LOX)

    Science.gov (United States)

    Miller, Richard

    2017-01-01

    The Lunar Occultation Explorer (LOX) is a next-generation mission concept that provides new capabilities for time-domain astrophysics and established the Moon as a platform for nuclear astrophysics. Performance requirements are driven by Type-Ia supernova (SNeIa) science goals that seek to revel details of these profoundly radioactive objects, including their diversity. Primary science objectives include, but are not limited to, probing the fundamental thermonuclear physics processes, performing a census of progenitors and their explosion mechanisms, and evaluating the environmental conditions and intrinsic systematics of these enigmatic objects. LOX provides new capabilities for all-sky, continuous monitoring in the MeV regime (0.1-10 MeV) by leveraging the Lunar Occultation Technique (LOT). Key benefits of the LOX/LOT approach include maximizing the ratio of sensitive-to-total deployed mass, low implementation risk, and demonstrated operational simplicity that leverages extensive experience with planetary orbital geochemistry investigations; LOX also enables long-term monitoring of MeV gamma-ray sources, a critical capability for SNeIa science. Proof-of-principle efforts validated all aspects of the mission using previously deployed lunar science assets, and led to the first high-energy gamma-ray source detected at the Moon. LOX mission performance, development progress, and expectations for science investigations will be presented.

  13. The ionosphere of Europa from Galileo radio occultations

    Science.gov (United States)

    Kliore, A. J.; Hinson, D. P.; Flasar, F. M.; Nagy, A. F.; Cravens, T. E.

    1997-01-01

    The Galileo spacecraft performed six radio occultation observations of Jupiter's Galilean satellite Europa during its tour of the jovian system. In five of the six instances, these occultations revealed the presence of a tenuous ionosphere on Europa, with an average maximum electron density of nearly 10(4) per cubic centimeter near the surface and a plasma scale height of about 240 +/- 40 kilometers from the surface to 300 kilometers and of 440 +/- 60 kilometers above 300 kilometers. Such an ionosphere could be produced by solar photoionization and jovian magnetospheric particle impact in an atmosphere having a surface density of about 10(8) electrons per cubic centimeter. If this atmosphere is composed primarily of O2, then the principal ion is O2+ and the neutral atmosphere temperature implied by the 240-kilometer scale height is about 600 kelvin. If it is composed of H2O, the principal ion is H3O+ and the neutral temperature is about 340 kelvin. In either case, these temperatures are much higher than those observed on Europa's surface, and an external heating source from the jovian magnetosphere is required.

  14. Waves in the Martian Atmosphere: Results from MGS Radio Occultations

    Science.gov (United States)

    Flasar, F. M.; Hinson, D. P.; Tyler, G. L.

    1999-01-01

    Temperatures retrieved from Mars Global Surveyor radio occultations have been searched for evidence of waves. Emphasis has been on the initial series of occultations between 29 deg N and 64 deg S, obtained during the early martian southern summer, L(sub s) = 264 deg - 308 deg. The profiles exhibit an undulatory behavior that is suggestive of vertically propagating waves. wavelengths approximately 10 km are often dominant, but structure on smaller scales is evident. The undulatory structure is most pronounced between latitudes 29 deg N and 10 deg S, usually in regions of "interesting" topography, e.g., in the Tharsis region and near the edge of Syrtis Major. Several temperature profiles, particularly within 30 deg of the equator, exhibit lapse rates that locally become superadiabatic near the 0.4-mbar level or at higher altitudes. This implies that the waves are "breaking" and depositing horizontal momentum into the atmosphere. Such a deposition may play an important role in modulating the atmospheric winds, and characterizing the spatial and temporal distribution of these momentum transfers can provide important clues to understanding how the global circulation is maintained.

  15. The floating cardiac fat pad-sign of occult pneumothorax.

    Science.gov (United States)

    Kaufman, Claire; Bokhari, S A Jamal

    2016-08-01

    Pneumothoraces are a possible sequela of chest trauma with potential morbidity and mortality if not recognized and treated promptly. A portable supine chest radiograph is frequently the first radiologic study performed in the setting of trauma. While large pneumothoraces can be readily recognized on these radiographs, smaller pneumothoraces are missed in up to 15 % of trauma patients. There are many radiographic signs of occult pneumothoraces, and we are presenting a new radiographic sign of occult pneumothorax. The floating cardiac fat pad sign occurs when pleural air collects anteriorly and superiorly in the most non-dependent portion of the chest lifting the pericardial fat pad off the diaphragm. Lung markings are still seen surrounding the pericardial fat pad due to the inflated lower lobe of the lung resting dependently. Rapid and accurate identification of pneumothoraces is critical but often difficult on chest radiographs. Although there are many existing radiographic signs for identification of pneumothorax, prospective identification of small pneumothoraces is still relatively poor. Here, we describe an additional sign which aides in the detection of pneumothoraces, the floating cardiac fat pad. When present, this should prompt further evaluation with chest CT or upright chest radiograph.

  16. The Interdependence of Long- and Short-Term Components in Unmasked Repetition Priming: An Indication of Shared Resources.

    Science.gov (United States)

    Merema, Matt R; Speelman, Craig P

    2015-01-01

    It has been suggested that unmasked repetition priming is composed of distinct long-and short-term priming components. The current study sought to clarify the relationship between these components by examining the relationship between them. A total of 60 people (45 females, 15 males) participated in a computer-based lexical decision task designed to measure levels of short-term priming across different levels of long-term priming. The results revealed an interdependent relationship between the two components, whereby an increase in long-term priming prompted a decrease in short-term priming. Both long-term and short-term priming were accurately captured by a single power function over seven minutes post repetition, suggesting the two components may draw on the same resources. This interdependence between long- and short-term priming may serve to improve fluency in reading.

  17. The Interdependence of Long- and Short-Term Components in Unmasked Repetition Priming: An Indication of Shared Resources.

    Directory of Open Access Journals (Sweden)

    Matt R Merema

    Full Text Available It has been suggested that unmasked repetition priming is composed of distinct long-and short-term priming components. The current study sought to clarify the relationship between these components by examining the relationship between them. A total of 60 people (45 females, 15 males participated in a computer-based lexical decision task designed to measure levels of short-term priming across different levels of long-term priming. The results revealed an interdependent relationship between the two components, whereby an increase in long-term priming prompted a decrease in short-term priming. Both long-term and short-term priming were accurately captured by a single power function over seven minutes post repetition, suggesting the two components may draw on the same resources. This interdependence between long- and short-term priming may serve to improve fluency in reading.

  18. Diffraction-based analysis of tunnel size for a scaled external occulter testbed

    Science.gov (United States)

    Sirbu, Dan; Kasdin, N. Jeremy; Vanderbei, Robert J.

    2016-07-01

    For performance verification of an external occulter mask (also called a starshade), scaled testbeds have been developed to measure the suppression of the occulter shadow in the pupil plane and contrast in the image plane. For occulter experiments the scaling is typically performed by maintaining an equivalent Fresnel number. The original Princeton occulter testbed was oversized with respect to both input beam and shadow propagation to limit any diffraction effects due to finite testbed enclosure edges; however, to operate at realistic space-mission equivalent Fresnel numbers an extended testbed is currently under construction. With the longer propagation distances involved, diffraction effects due to the edge of the tunnel must now be considered in the experiment design. Here, we present a diffraction-based model of two separate tunnel effects. First, we consider the effect of tunnel-edge induced diffraction ringing upstream from the occulter mask. Second, we consider the diffraction effect due to clipping of the output shadow by the tunnel downstream from the occulter mask. These calculations are performed for a representative point design relevant to the new Princeton occulter experiment, but we also present an analytical relation that can be used for other propagation distances.

  19. Occult HBV infection in HIV-infected adults and evaluation of pooled NAT for HBV.

    Science.gov (United States)

    Dinesha, T R; Boobalan, J; Sivamalar, S; Subashini, D; Solomon, S S; Murugavel, K G; Balakrishnan, P; Smith, D M; Saravanan, S

    2018-01-06

    The study aimed to determine the prevalence of occult hepatitis B virus infection among HIV-infected persons and to evaluate the use of a pooling strategy to detect occult HBV infection in the setting of HIV infection. Five hundred and two HIV-positive individuals were tested for HBV, occult HBV and hepatitis C and D with serologic and nucleic acid testing (NAT). We also evaluated a pooled NAT strategy for screening occult HBV infection among the HIV-positive individuals. The prevalence of HBV infection among HIV-positive individuals was 32 (6.4%), and occult HBV prevalence was 10%. The pooling HBV NAT had a sensitivity of 66.7% and specificity of 100%, compared to HBV DNA NAT of individual samples. In conclusion, this study found a high prevalence of occult HBV infection among our HIV-infected population. We also demonstrated that pooled HBV NAT is highly specific, moderately sensitive and cost-effective. As conventional HBV viral load assays are expensive in resource-limited settings such as India, pooled HBV DNA NAT might be a good way for detecting occult HBV infection and will reduce HBV-associated complications. © 2018 John Wiley & Sons Ltd.

  20. Noninvasive Prenatal Testing and Incidental Detection of Occult Maternal Malignancies.

    Science.gov (United States)

    Bianchi, Diana W; Chudova, Darya; Sehnert, Amy J; Bhatt, Sucheta; Murray, Kathryn; Prosen, Tracy L; Garber, Judy E; Wilkins-Haug, Louise; Vora, Neeta L; Warsof, Stephen; Goldberg, James; Ziainia, Tina; Halks-Miller, Meredith

    2015-07-14

    Understanding the relationship between aneuploidy detection on noninvasive prenatal testing (NIPT) and occult maternal malignancies may explain results that are discordant with the fetal karyotype and improve maternal clinical care. To evaluate massively parallel sequencing data for patterns of copy-number variations that might prospectively identify occult maternal malignancies. Case series identified from 125,426 samples submitted between February 15, 2012, and September 30, 2014, from asymptomatic pregnant women who underwent plasma cell-free DNA sequencing for clinical prenatal aneuploidy screening. Analyses were conducted in a clinical laboratory that performs DNA sequencing. Among the clinical samples, abnormal results were detected in 3757 (3%); these were reported to the ordering physician with recommendations for further evaluation. NIPT for fetal aneuploidy screening (chromosomes 13, 18, 21, X, and Y). Detailed genome-wide bioinformatics analysis was performed on available sequencing data from 8 of 10 women with known cancers. Genome-wide copy-number changes in the original NIPT samples and in subsequent serial samples from individual patients when available are reported. Copy-number changes detected in NIPT sequencing data in the known cancer cases were compared with the types of aneuploidies detected in the overall cohort. From a cohort of 125,426 NIPT results, 3757 (3%) were positive for 1 or more aneuploidies involving chromosomes 13, 18, 21, X, or Y. From this set of 3757 samples, 10 cases of maternal cancer were identified. Detailed clinical and sequencing data were obtained in 8. Maternal cancers most frequently occurred with the rare NIPT finding of more than 1 aneuploidy detected (7 known cancers among 39 cases of multiple aneuploidies by NIPT, 18% [95% CI, 7.5%-33.5%]). All 8 cases that underwent further bioinformatics analysis showed unique patterns of nonspecific copy-number gains and losses across multiple chromosomes. In 1 case, blood was

  1. First light of an external occulter testbed at flight Fresnel numbers

    Science.gov (United States)

    Kim, Yunjong; Sirbu, Dan; Hu, Mia; Kasdin, Jeremy; Vanderbei, Robert J.; Harness, Anthony; Shaklan, Stuart

    2017-01-01

    Many approaches have been suggested over the last couple of decades for imaging Earth-like planets. One of the main candidates for creating high-contrast for future Earth-like planets detection is an external occulter. The external occulter is a spacecraft flown along the line-of-sight of a space telescope to suppress starlight and enable high-contrast direct imaging of exoplanets. The occulter is typically tens of meters in diameter and the separation from the telescope is of the order of tens of thousands of kilometers. Optical testing of a full-scale external occulter on the ground is impossible because of the long separations. Therefore, laboratory verification of occulter designs is necessary to validate the optical models used to design and predict occulter performance. At Princeton, we have designed and built a testbed that allows verification of scaled occulter designs whose suppressed shadow is mathematically identical to that of space occulters. The goal of this experiment is to demonstrate a pupil plane suppression of better than 1e-9 with a corresponding image plane contrast of better than 1e-11. The occulter testbed uses a 77.2 m optical propagation distance to realize the flight Fresnel number of 14.5. The scaled mask is placed at 27.2 m from the artificial source and the camera is located 50.0 m from the scaled mask. We will use an etched silicon mask, manufactured by the Microdevices Lab(MDL) of the Jet Propulsion Laboratory(JPL), as the occulter. Based on conversations with MDL, we expect that 0.5 μm feature size is an achievable resolution in the mask manufacturing process and is therefore likely the indicator of the best possible performance. The occulter is illuminated by a diverging laser beam to reduce the aberrations from the optics before the occulter. Here, we present first light result of a sample design operating at a flight Fresnel number and the experimental setup of the testbed. We compare the experimental results with simulations

  2. Influence of misalignments on the performance of externally occulted solar coronagraphs. Application to PROBA-3/ASPIICS

    Science.gov (United States)

    Shestov, S. V.; Zhukov, A. N.

    2018-05-01

    Context. The ASPIICS instrument is a novel externally occulted coronagraph that will be launched on board the PROBA-3 mission of the European Space Agency. The external occulter will be placed on one satellite 150 m ahead of the second satellite that will carry an optical instrument. During 6 h out of 19.38 h of orbit, the satellites will fly in a precise (accuracy around a few millimeters) formation, constituting a giant externally occulted coronagraph. The large distance between the external occulter and the primary objective will allow observations of the white-light solar corona starting from extremely low heights 1.1R⊙. Aims: We intend to analyze influence of shifts of the satellites and misalignments of optical elements on the ASPIICS performance in terms of diffracted light. Based on the quantitative influence of misalignments on diffracted light, we provide a recipe for choosing the size of the internal occulter (IO) to achieve a trade-off between the minimal height of observations and sustainability to possible misalignments. Methods: We considered different types of misalignments and analyzed their influence from optical and computational points of view. We implemented a numerical model of the diffracted light and its propagation through the optical system and computed intensities of diffracted light throughout the instrument. Our numerical approach is based on a model from the literature that considered the axisymmetrical case. Here we extend the model to include nonsymmetrical cases and possible misalignments. Results: The numerical computations fully confirm the main properties of the diffracted light that we obtained from semi-analytical consideration. We obtain that relative influences of various misalignments are significantly different. We show that the internal occulter with RIO = 1.694 mm = 1.1R⊙ is large enough to compensate possible misalignments expected to occur in PROBA-3/ASPIICS. Besides that we show that apodizing the edge of the

  3. Heparin as a pharmacologic intervention to induce positive scintiscan in occult gastrointestinal bleeding

    International Nuclear Information System (INIS)

    Chaudhuri, T.K.; Brantly, M.

    1984-01-01

    The value of using heparin as a pharmacologic intervention to induce a positive scintiscan was studied in a patient with chronic occult gastrointestinal bleeding. When all standard diagnostic tests (upper and lower gastrointestinal series, upper and lower endoscopy, and conventional noninterventional Tc-99m RBC imaging) fail to detect and localize gastrointestinal bleeding in a patient who has definite clinical evidence (guaiac positive stool and dropping hemoglobin, hematocrit) of chronic occult gastrointestinal oozing, heparin may be used (with proper precaution) as a last resort to aid in the scintigraphic detection and localization of chronic occult gastrointestinal bleeding

  4. Acute Zonal Occult Outer Retinopathy with Atypical Findings

    Directory of Open Access Journals (Sweden)

    Dimitrios Karagiannis

    2014-01-01

    Full Text Available Background. To report a case of acute zonal occult outer retinopathy (AZOOR with atypical electrophysiology findings. Case Presentation. A 23-year-old-female presented with visual acuity deterioration in her right eye accompanied by photopsia bilaterally. Corrected distance visual acuity at presentation was 20/50 in the right eye and 20/20 in the left eye. Fundus examination was unremarkable. Visual field (VF testing revealed a large scotoma. Pattern and full-field electroretinograms (PERG and ERG revealed macular involvement associated with generalized retinal dysfunction. Electrooculogram (EOG light rise and the Arden ratio were within normal limits bilaterally. The patient was diagnosed with AZOOR due to clinical findings, visual field defect, and ERG findings. Conclusion. This is a case of AZOOR with characteristic VF defects and clinical symptoms presenting with atypical EOG findings.

  5. Radiosensitive orbital metastasis as presentation of occult colonic adenocarcinoma.

    Science.gov (United States)

    Ludmir, Ethan B; McCall, Shannon J; Czito, Brian G; Palta, Manisha

    2014-09-19

    An 82-year-old man presented with progressive right frontal headaches. The patient's history was significant for benign polyps on surveillance colonoscopy 2 years prior, without high-grade dysplasia or carcinoma. MRI revealed an enhancing lesion arising within the superomedial aspect of the right orbit. Lesion biopsy demonstrated histological appearance and immunophenotype suggestive of colonic adenocarcinoma. Staging positron emission tomography/CT showed visceral metastases and diffuse activity in the posterior rectosigmoid, consistent with metastatic colon cancer. Treatment of the orbital lesion with external beam radiotherapy to 30 Gy resulted in significant palliation of the patient's headaches. The patient expired 2 months following treatment completion due to disease progression. Orbital metastasis as the initial presentation of an occult colorectal primary lesion is exceedingly rare, and occurred in this patient despite surveillance colonoscopy. Radiotherapy remains an efficacious modality for treatment of orbital metastases. 2014 BMJ Publishing Group Ltd.

  6. Lunar occultations for gamma-ray source measurements

    Science.gov (United States)

    Koch, David G.; Hughes, E. B.; Nolan, Patrick L.

    1990-01-01

    The unambiguous association of discrete gamma-ray sources with objects radiating at other wavelengths, the separation of discrete sources from the extended emission within the Galaxy, the mapping of gamma-ray emission from nearby galaxies and the measurement of structure within a discrete source cannot presently be accomplished at gamma-ray energies. In the past, the detection processes used in high-energy gamma-ray astronomy have not allowed for good angular resolution. This problem can be overcome by placing gamma-ray detectors on the moon and using the horizon as an occulting edge to achieve arcsec resolution. For purposes of discussion, this concept is examined for gamma rays above 100 MeV for which pair production dominates the detection process and locally-generated nuclear gamma rays do not contribute to the background.

  7. Adolescent Occultism and the Philosophy of Things in Three Novels

    Directory of Open Access Journals (Sweden)

    Samuel Finegan

    2015-11-01

    Full Text Available Shirley Jackson’s 1962 We Have Always Lived in the Castle, Iain Banks’s 1984 The Wasp Factory and Sonya Hartnett’s 2009 Butterfly are novels separated not only by decades, but by distance being produced in the United States, Scotland and Australia respectively. Despite this, each of these texts depicts a young adult in a mimetically recognisable world struggling to reconcile their intuitive occultism with that world. The mediation of magic through assemblages of charged objects creates a philosophy of things – modelling in intuitive and narrative terms the essence and nature of objects familiar from the philosophies of Martin Heidegger and Walter Benjamin. As such, the supernaturalism of Iain Banks, Shirley Jackson and Sonya Hartnett’s narratives implicates their readers – breaking the boundaries of fiction to comment on the material world itself, not through analogy or metaphor but through direct modelling of the potential power and worth of things.

  8. Occult posterolateral rotatory dislocation of the elbow with olecranon fracture in a child: a case report

    Directory of Open Access Journals (Sweden)

    Fujimori Takahito

    2012-09-01

    Full Text Available Abstract Introduction Acute posterolateral rotator elbow dislocation in a child is rare and can be easily misdiagnosed due to immaturity of the epiphysis. This is the first case of occult posterolateral rotator elbow dislocation in combination with an olecranon fracture. We report our experience with this case, which was not diagnosed correctly by plain radiographs. Case presentation An 11-year-old Asian boy suffered severe pain and swelling of his right elbow after his outstretched arm hit a car dashboard in a motor vehicle accident. Plain radiographs showed only a minimally displaced olecranon fracture and a tiny lateral epicondylar avulsion fracture. However, stress radiographs under general anesthesia revealed severe posterolateral rotatory instability. During surgery, we found that the cartilaginous lateral epicondylar apophysis was much larger than the epicondylar fragment on the radiographs. After the lateral epicondylar osteochondral fragment and lateral collateral ligament complex were fixed, the instability disappeared. Conclusion Our experience with this case shows that it is important to check for instability with pediatric elbow fractures, because a tiny avulsion fracture was able to cause severe posterolateral rotatory instability in a child.

  9. Small Spacecraft Constellation Concept for Mars Atmospheric Radio Occultations

    Science.gov (United States)

    Asmar, S. W.; Mannucci, A. J.; Ao, C. O.; Kobayashi, M. M.; Lazio, J.; Marinan, A.; Massone, G.; McCandless, S. E.; Preston, R. A.; Seubert, J.; Williamson, W.

    2017-12-01

    First demonstrated in 1965 when Mariner IV flew by Mars and determined the salient features of its atmosphere, radio occultation experiments have been carried out on numerous planetary missions with great discoveries. These experiments utilize the now classic configuration of a signal from a single planetary spacecraft to Earth receiving stations, where the science data are acquired. The Earth science community advanced the technique to utilizing a constellation of spacecraft with the radio occultation links between the spacecraft, enabled by the infrastructure of the Global Positioning System. With the advent of small and less costly spacecraft, such as planetary CubeSats and other variations, such as the anticipated innovative Mars Cube One mission, crosslinks among small spacecraft can be used to study other planets in the near future. Advantages of this type of experiment include significantly greater geographical coverage, which could reach global coverage over a few weeks with a small number of spacecraft. Repeatability of the global coverage can lead to examining temperature-pressure profiles and ionospheric electron density profiles, on daily, seasonal, annual, or other time scales of interest. The higher signal-to-noise ratio for inter-satellite links, compared to a link to Earth, decreases the design demands on the instrumentation (smaller antennas and transmitters, etc.). After an actual Mars crosslink demonstration, this concept has been in development using Mars as a possible target. Scientific objectives, delivery methods, operational scenarios and end-to-end configuration have been documented. Science objectives include determining the state and variability of the lower Martian atmosphere, which has been an identified as a high priority objective by the Mars Exploration Program Analysis Group, particularly as it relates to entry, descent, and landing and ascent for future crewed and robotic missions. This paper will present the latest research on the

  10. The prototype cameras for trans-Neptunian automatic occultation survey

    Science.gov (United States)

    Wang, Shiang-Yu; Ling, Hung-Hsu; Hu, Yen-Sang; Geary, John C.; Chang, Yin-Chang; Chen, Hsin-Yo; Amato, Stephen M.; Huang, Pin-Jie; Pratlong, Jerome; Szentgyorgyi, Andrew; Lehner, Matthew; Norton, Timothy; Jorden, Paul

    2016-08-01

    The Transneptunian Automated Occultation Survey (TAOS II) is a three robotic telescope project to detect the stellar occultation events generated by TransNeptunian Objects (TNOs). TAOS II project aims to monitor about 10000 stars simultaneously at 20Hz to enable statistically significant event rate. The TAOS II camera is designed to cover the 1.7 degrees diameter field of view of the 1.3m telescope with 10 mosaic 4.5k×2k CMOS sensors. The new CMOS sensor (CIS 113) has a back illumination thinned structure and high sensitivity to provide similar performance to that of the back-illumination thinned CCDs. Due to the requirements of high performance and high speed, the development of the new CMOS sensor is still in progress. Before the science arrays are delivered, a prototype camera is developed to help on the commissioning of the robotic telescope system. The prototype camera uses the small format e2v CIS 107 device but with the same dewar and also the similar control electronics as the TAOS II science camera. The sensors, mounted on a single Invar plate, are cooled to the operation temperature of about 200K as the science array by a cryogenic cooler. The Invar plate is connected to the dewar body through a supporting ring with three G10 bipods. The control electronics consists of analog part and a Xilinx FPGA based digital circuit. One FPGA is needed to control and process the signal from a CMOS sensor for 20Hz region of interests (ROI) readout.

  11. Between occultism and drama. Henrik Ibsen and Aleister Crowley

    Directory of Open Access Journals (Sweden)

    Giuliano D' Amico

    2015-02-01

    Full Text Available The article investigates the references to the works of Henrik Ibsen that the writer and occultist Aleister Crowley scattered in his writings around the turn of the 20th century, in the early phase of his career as a writer and occultist. Crowley’s reading of Ibsen has a marked a socio-political bent, especially in his interpretation of the work of the Norwegian playwright as an act of rebellion against the bourgeois (and for Crowley, Victorian system of values. Also, such view is enriched by a spiritual and individualistic interpretation of Ibsen as an “Artist”, i.e., in the light of Crowley’s occult doctrine, Thelema, of an individual who has found his own “Will” and can inspire others to do so. Such social and spiritual interpretations of Ibsen on Crowley’s part found their literary realization in his one-act play The Mother’s Tragedy (1899. The article claims that Crowley’s reading of Ibsen can give some new insight in the mechanisms of reception of the Norwegian playwright, by opening up for a reading of some of his plays within an occult discourse. Also, it is an occasion to treat Crowley – a figure that was constantly present in the European cultural and literary life of the last decade of the 19th century and of the first five decades of the 20th – with a different attitude than the irony and disdain to which he is often exposed.

  12. Mapping Pluto's Temperature Distribution Through Twenty Years of Stellar Occultations

    Science.gov (United States)

    Zangari, Amanda; Binzel, R. P.; Person, M. J.

    2012-10-01

    Multi-chord, high signal-to-noise Pluto occultations have been observed several times over the past two decades, including events in 1988, 2002, 2006, 2007, 2010 and 2011 (Elliot et al. 1989, 2003, 2007; Person et al. 2008, 2010, 2011). We fit separate immersion and emersion occultation light-curve models to each of the individual light curves obtained from these efforts. Asymmetries in the light curves result in the half-light temperatures for opposite sides of a single chord to differ by up to 20 Kelvin in the largest case. The temperature difference for each chord is consistent using both isothermal (b=0) and non-isothermal (e.g. b=-2.2) models based on the methodology described by Elliot & Young (1992). We examine the relationship between the location of immersion and emersion points on Pluto and these temperatures at the half-light radius and will present results for correlations between these location/temperature data and surface composition maps, Pluto geometry, and accumulated insolation patterns. This work was supported by NASA Planetary Astronomy Grant to MIT (NNX10AB27G), and NSF Astronomy and Astrophysics Grant to MIT (0707609). The authors would like to acknowledge the late Professor James L. Elliot for his efforts in beginning this work. References: Elliot, J. L., Dunham, E. W., Bosh, A. S., et al. 1989, Icarus, 77,148 Elliot, J. L., Ates, A., Babcock, B. A., et al. 2003, Nature, 424,165 Elliot, J. L., Person, M. J., Gulbis, A. A. S., et al. 2007, AJ, 134, 1 Elliot, J. L., & Young, L. A. 1992, AJ, 103, 991. Person, M. J., Elliot, J. L., Gulbis, A. A. S., et al. 2008, AJ, 136, 1510 Person, M. J., Elliot, J. L., Bosh, A. S., et al. 2010, Bulletin of the American Astronomical Society, 42, 983 Person, M. J., Dunham, E. W., Bida, T., et al. 2011, EPSC-DPS Joint Meeting 2011, 1374.

  13. Magellan radio occultation measurements of atmospheric waves on Venus

    Science.gov (United States)

    Hinson, David P.; Jenkins, J. M.

    1995-01-01

    Radio occultation experiments were conducted at Venus on three consecutive orbits of the Magellan spacecraft in October 1991. Each occultation occurred over the same topography (67 deg N, 127 deg E) and at the same local time (22 hr 5 min), but the data are sensitive to zonal variations because the atmosphere rotates significantly during one orbit. Through comparisons between observations and predictions of standard wave theory, we have demonstrated that small-scale oscillations in retrieved temperature profiles as well as scintillations in received signal intensity are caused by a spectrum of vertically propagating internal gravity waves. There is a strong similarity between the intensity scintillations observed here and previous measurements, which pertain to a wide range of locations and experiment dates. This implies that the same basic phenomenon underlies all the observations and hence that gravity waves are a persistent, global feature of Venus' atmosphere. We obtained a fairly complete characterization of a gravity wave that appears above the middle cloud in temperature measurements on all three orbits. The amplitude and vertical wavelength are about 4 K and 2.5 km respectively, at 65 km. A model for radiative damping implies that the wave intrinsic frequency is approximately 2 x 10(exp 4) rad/sec, the corresponding ratio between horizontal and vertical wavelengths is approximately 100. The wave is nearly stationary relative to the surface or the Sun. Radiative attenuation limits the wave amplitude at altitudes above approximately 65 km, leading to wave drag on the mean zonal winds of about +0.4 m/sec per day (eastward). The sign, magnitude, and location of this forcing suggest a possible role in explaining the decrease with height in the zonal wind speed that is believed to occur above the cloud tops. Temperature oscillations with larger vertical wavelengths (5-10 km) were also observed on all three orbits, but we are able unable to interpret these

  14. Immunohistochemical detection of VHS virus in paraffin-embedded specimens of rainbow trout (Oncorhynchus mykiss); The influence of primary antibody, fixative, and antigen unmasking on method sensitivity

    DEFF Research Database (Denmark)

    Evensen, O.; Olesen, Niels Jørgen

    1997-01-01

    performed on parallel specimens, and the virus titer (TCID50/ml) was determined. Purified nucleocapsid protein (N-protein) of the virus was incorporated in an artificial antigen substrate (polymerized bovine serum albumin), fixed as described above, and embedded in paraffin wax. Microwave unmasking...... was performed an formalin-, PLP-, and Bouin's fluid-fixed specimens. The presence of virus peptides in situ or N-protein in the artificial antigen substrates was Visualized using an immunohistochemical method based on alkaline phosphatase or peroxidase and one polyclonal and five monoclonal polypeptide......-specific antibodies. VHS virus was identified in situ in specimens with high virus titers (10(7-8) TCID50/ml) regardless of the fixative and without the need of an unmasking procedure. A pronounced masking effect was observed for the cross-linking formalin and PLP fixatives. Regardless of the primary antibodies used...

  15. Fecal Occult Blood Test (FOBT): MedlinePlus Lab Test Information

    Science.gov (United States)

    ... caused by a variety of conditions, including: Polyps Hemorrhoids Diverticulosis Ulcers Colitis , a type of inflammatory bowel ... on a fecal occult blood test include ulcers, hemorrhoids, polyps, and benign tumors. If your test results ...

  16. Observations of Hot-Jupiter occultations combining Spitzer and Kepler photometry

    Directory of Open Access Journals (Sweden)

    Knutson H.

    2011-02-01

    Full Text Available We present the status of an ongoing program which aim at measuring occultations by their parent stars of transiting hot giant exoplanets discovered recently by Kepler. The observations are obtained in the near infrared with WarmSpitzer Space Telescope and at optical wavelengths by combining more than a year of Kepler photometry. The investigation consists of measuring the mid-occultation times and the relative occultation depths in each band-passes. Our measurements of occultations depths in the Kepler bandpass is turned into the determination of the optical geometric albedo Ag in this wavelength domain. The brightness temperatures of these planets are deduced from the infrared observations. We combine the optical and near infrared planetary emergent fluxes to obtain broad band emergent spectra of individual planet. We finally compare these spectra to hot Jupiter atmospheric models in order broadly distinguishing these atmospheres between different classes of models.

  17. Parapsychology on the couch: the psychology of occult belief in Germany, c. 1870-1939.

    Science.gov (United States)

    Wolffram, Heather

    2006-01-01

    This article considers the attempts of academic psychologists and critical occultists in Germany during the late nineteenth and early twentieth centuries to construct a psychology of occult belief. While they claimed that the purpose of this new subdiscipline was to help evaluate the work of occult researchers, the emergence of a psychology of occult belief in Germany served primarily to pathologize parapsychology and its practitioners. Not to be outdone, however, parapsychologists argued that their adversaries suffered from a morbid inability to accept the reality of the paranormal. Unable to resolve through experimental means the dispute over who should be allowed to mold the public's understanding of the occult, both sides resorted to defaming their opponent. (c) 2006 Wiley Periodicals, Inc.

  18. Metastatic Squamous Neck Cancer with Occult Primary Treatment (PDQ®)—Health Professional Version

    Science.gov (United States)

    Metastatic squamous neck cancer with occult primary treatment options include surgery, radiation therapy or a combination of both. Get detailed information about newly diagnosed or recurrent metastatic squamous neck cancer in this summary for clinicians.

  19. Metastatic Squamous Neck Cancer with Occult Primary Treatment (PDQ®)—Patient Version

    Science.gov (United States)

    Metastatic squamous neck cancer with occult primary (unknown primary) treatment options include surgery, radiation therapy, or a combination of both. Learn more about the diagnosis and treatment of these tumors in this expert-reviewed summary.

  20. Low-Cost Small Satellite Atmospheric Rotating Solar Occultation Imager (ROI)

    Data.gov (United States)

    National Aeronautics and Space Administration — Utilizing a unique, new occultation technique involving imaging, the ROI concept will meet or exceed the quality of SAGE measurements at a small fraction of the...

  1. Prevalence of Visible and Occult Blood on the Surfaces of Fiberoptic Bronchoscopes

    National Research Council Canada - National Science Library

    McKamey, Jeffrey

    2000-01-01

    .... This study was conducted to determine if current cleaning, disinfection and sterilization procedures used at one medical center was adequate to remove visible and occult blood from fiberoptic bronchoscopes...

  2. Follicle-stimulating hormone (FSH) unmasks specific high affinity FSH-binding sites in cell-free membrane preparations of porcine granulosa cells

    Energy Technology Data Exchange (ETDEWEB)

    Ford, K.A.; LaBarbera, A.R.

    1988-11-01

    The purpose of these studies was to determine whether changes in FSH receptors correlated with FSH-induced attenuation of FSH-responsive adenylyl cyclase in immature porcine granulosa cells. Cells were incubated with FSH (1-1000 ng/ml) for up to 24 h, treated with acidified medium (pH 3.5) to remove FSH bound to cells, and incubated with (125I)iodo-porcine FSH to quantify FSH-binding sites. FSH increased binding of FSH in a time-, temperature-, and FSH concentration-dependent manner. FSH (200 ng/ml) increased binding approximately 4-fold within 16 h. Analysis of equilibrium saturation binding data indicated that the increase in binding sites reflected a 2.3-fold increase in receptor number and a 5.4-fold increase in apparent affinity. The increase in binding did not appear to be due to 1) a decrease in receptor turnover, since the basal rate of turnover appeared to be very slow; 2) an increase in receptor synthesis, since agents that inhibit protein synthesis and glycosylation did not block the increase in binding; or 3) an increase in intracellular receptors, since agents that inhibit cytoskeletal components had no effect. Agents that increase intracellular cAMP did not affect FSH binding. The increase in binding appeared to result from unmasking of cryptic FSH-binding sites, since FSH increased binding in cell-free membrane preparations to the same extent as in cells. Unmasking of cryptic sites was hormone specific, and the sites bound FSH specifically. Unmasking of sites was reversible in a time- and temperature-dependent manner after removal of bound FSH. The similarity between the FSH dose-response relationships for unmasking of FSH-binding sites and attenuation of FSH-responsive cAMP production suggests that the two processes are functionally linked.

  3. Detection of an occult transclival cerebrospinal fluid fistula by CT and MRI

    International Nuclear Information System (INIS)

    Schick, B.; Brors, D.; Draf, W.; Goedecke, A.; Prescher, A.

    1998-01-01

    We describe an unusual occult transclival cerebrospinal fluid (CSF) fistula to the sphenoid sinus demonstrated by MRI. CT was performed because of a posterior cerebral infarct caused by cardiac arrhythmia. Axial sections showed fluid in the sphenoid sinus. High-resolution scans revealed a bony defect 3 mm in diameter of the posterior wall of the sphenoid sinus, and MRI showed a transclival CSF fistula. This occult lesion was confirmed by surgery and duraplasty was successfully performed via an endonasal approach. (orig.)

  4. Satellite Gravity Transforms Unmask Tectonic Pattern of Arabian-African Region

    Science.gov (United States)

    Eppelbaum, Lev; Katz, Youri

    2017-04-01

    Satellite derived geophysical gravity data are the modern powerful tool of regional tectono-geophysical examination of the Earth's crust and upper mantle. It is well known that regional long-term seismological prognosis, strategy of searching economic deposits and many other important geological-geophysical problems are based mainly on constructions derived from the combined tectono-geophysical zonation. Some authors' experience of the tectono-geophysical zonation in the Eastern Mediterranean (both sea and land) with satellite derived gravity field (Eppelbaum and Katz, 2015a, 2015b) indicates a high effectiveness of the data employment for delineation of different tectono-structural units. Therefore, on the basis of the previous successive application, satellite derived gravity field analysis was applied for a giant (covering > 10 mln. km2) and complex Arabian-African region (including Zagros Mts.). The gravity field retracked from the Geosat and ERS-1 altimetry (e.g., Sandwell and Smith, 2009) was processed by the use of different mathematical apparatus employment enabling to underline these or those tectonic (geodynamic) features of the region under study. The main goals of present investigation are following: (1) employment of a new powerful regional geophysical tool - satellite derived gravity data and its transforms for unmasking some buried tectonic and geodynamic peculiarities of the study area, (2) finding definite relationships between the novel tectonic map and the gravity field transformations, (3) development of a novel tectonic map of this area (on the basis of careful examination of and generalization of available geological and geophysical (mostly satellite gravity) data). The compiled gravity map (for the map compiling more than 4 mln. observations were utilized) with the main tectonic features shows the intricate gravity pattern of the investigated area. An initial analysis of the gravity field behavior enabled to separate two main types of

  5. Potential overestimation of HPV vaccine impact due to unmasking of non-vaccine types: quantification using a multi-type mathematical model.

    Science.gov (United States)

    Choi, Yoon Hong; Chapman, Ruth; Gay, Nigel; Jit, Mark

    2012-05-14

    Estimates of human papillomavirus (HPV) vaccine impact in clinical trials and modelling studies rely on DNA tests of cytology or biopsy specimens to determine the HPV type responsible for a cervical lesion. DNA of several oncogenic HPV types may be detectable in a specimen. However, only one type may be responsible for a particular cervical lesion. Misattribution of the causal HPV type for a particular abnormality may give rise to an apparent increase in disease due to non-vaccine HPV types following vaccination ("unmasking"). To investigate the existence and magnitude of unmasking, we analysed data from residual cytology and biopsy specimens in English women aged 20-64 years old using a stochastic type-specific individual-based model of HPV infection, progression and disease. The model parameters were calibrated to data on the prevalence of HPV DNA and cytological lesion of different grades, and used to assign causal HPV types to cervical lesions. The difference between the prevalence of all disease due to non-vaccine HPV types, and disease due to non-vaccine HPV types in the absence of vaccine HPV types, was then estimated. There could be an apparent maximum increase of 3-10% in long-term cervical cancer incidence due to non-vaccine HPV types following vaccination. Unmasking may be an important phenomenon in HPV post-vaccination epidemiology, in the same way that has been observed following pneumococcal conjugate vaccination. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. A prospective evaluation of occult disorders in obstructed defecation using the 'iceberg diagram'.

    Science.gov (United States)

    Pescatori, M; Spyrou, M; Pulvirenti d'Urso, A

    2007-06-01

    Surgical treatment of constipation and obstructed defecation (OD) carries frequent recurrences, as OD is an 'iceberg syndrome' characterized by 'underwater rocks' or occult diseases which may affect the outcome of surgery. The aim of this study was to evaluate occult disorders, in order to alert the clinician of these and minimize failures. One hundred consecutive constipated patients with OD symptoms, 81 women, median age 52 years, underwent perineal examination, proctoscopy, anorectal manometry and anal/vaginal ultrasound (US). Anorectal physiology and imaging tests were also carried out when indicated, as well as psychological and urogynaecological consultations. Symptoms were graded using a modified 1-20 constipation score. Both evident (e.g. rectocele) and occult (e.g. anismus) diseases were prospectively evaluated using a novel 'iceberg diagram'. The type of treatment, whether conservative or surgical, was also recorded. Fifty-four (54%) patients had both mucosal prolapse and rectocele. All patients had at least two occult OD-related diseases, 66 patients had at least three of them: anxiety-depression, anismus and rectal hyposensation were the most frequent (66%, 44% and 33%, respectively). The median constipation score was 11 (range 2-20), the median number of 'occult disorders' was 5 (range 2-8). Conservative treatment was carried out in most cases. Surgery was carried out in 14 (14%) patients. The novel 'iceberg diagram' allowed the adequate evaluation of OD-related occult diseases and better selection of patients for treatment. Most were managed conservatively, and only a minority were treated by surgery.

  7. Scaled model guidelines for solar coronagraphs' external occulters with an optimized shape.

    Science.gov (United States)

    Landini, Federico; Baccani, Cristian; Schweitzer, Hagen; Asoubar, Daniel; Romoli, Marco; Taccola, Matteo; Focardi, Mauro; Pancrazzi, Maurizio; Fineschi, Silvano

    2017-12-01

    One of the major challenges faced by externally occulted solar coronagraphs is the suppression of the light diffracted by the occulter edge. It is a contribution to the stray light that overwhelms the coronal signal on the focal plane and must be reduced by modifying the geometrical shape of the occulter. There is a rich literature, mostly experimental, on the appropriate choice of the most suitable shape. The problem arises when huge coronagraphs, such as those in formation flight, shall be tested in a laboratory. A recent contribution [Opt. Lett.41, 757 (2016)OPLEDP0146-959210.1364/OL.41.000757] provides the guidelines for scaling the geometry and replicate in the laboratory the flight diffraction pattern as produced by the whole solar disk and a flight occulter but leaves the conclusion on the occulter scale law somehow unjustified. This paper provides the numerical support for validating that conclusion and presents the first-ever simulation of the diffraction behind an occulter with an optimized shape along the optical axis with the solar disk as a source. This paper, together with Opt. Lett.41, 757 (2016)OPLEDP0146-959210.1364/OL.41.000757, aims at constituting a complete guide for scaling the coronagraphs' geometry.

  8. Extent and kinetics of recovery of occult spinal cord injury

    International Nuclear Information System (INIS)

    Ang, K. Kian; Jiang, G.-L.; Feng Yan; Stephens, L. Clifton; Tucker, Susan L.; Price, Roger E.

    2001-01-01

    Purpose: To obtain clinically useful quantitative data on the extent and kinetics of recovery of occult radiation injury in primate spinal cord, after a commonly administered elective radiation dose of 44 Gy, given in about 2 Gy per fraction. Methods and Materials: A group of 56 rhesus monkeys was assigned to receive two radiation courses to the cervical and upper thoracic spinal cord, given in 2.2 Gy per fraction. The dose of the initial course was 44 Gy in all monkeys. Reirradiation dose was 57.2 Gy, given after 1-year (n 16) or 2-year (n = 20) intervals, or 66 Gy, given after 2-year (n = 4) or 3-year (n = 14) intervals. Two animals developed intramedullary tumors before reirradiation and, therefore, did not receive a second course. The study endpoint was myeloparesis, manifesting predominantly as lower extremity weakness and decrease in balance, occurring within 2.5 years after reirradiation, complemented by histologic examination of the spinal cord. The data obtained were analyzed along with data from a previous study addressing single-course tolerance, and data from a preliminary study of reirradiation tolerance. Results: Only 4 of 45 monkeys completing the required observation period (2-2.5 years after reirradiation, 3-5.5 years total) developed myeloparesis. The data revealed a substantial recovery of occult injury induced by 44 Gy within the first year, and suggested additional recovery between 1 and 3 years. Fitting the data with a model, assuming that all (single course and reirradiation) dose-response curves were parallel, yielded recovery estimates of 33.6 Gy (76%), 37.6 Gy (85%), and 44.6 Gy (101%) of the initial dose, after 1, 2, and 3 years, respectively, at the 5% incidence (D 5 ) level. The most conservative estimate, using a model in which it was assumed that there was no recovery between 1 and 3 years following initial irradiation and that the combined reirradiation curve was not necessarily parallel to the single-course curve, still showed an

  9. Adrenal Insufficiency, Sex Reversal, and Angelman Syndrome due to Uniparental Disomy Unmasking a Mutation in CYP11A1.

    Science.gov (United States)

    Kim, Ahlee; Fujimoto, Masanobu; Hwa, Vivian; Backeljauw, Philippe; Dauber, Andrew

    2018-01-01

    Cholesterol side-chain cleavage enzyme (P450scc) deficiency is a rare genetic disorder causing primary adrenal insufficiency with or without a 46,XY disorder of sexual development (DSD). Herein, we report a case of the combination of primary adrenal insufficiency, a DSD (testes with female external genitalia in a setting of a 47,XXY karyotype), and Angelman syndrome. Comprehensive genetic analyses were performed, including a single nucleotide polymorphism microarray and whole-exome sequencing. In vitro studies were performed to evaluate the pathogenicity of the novel mutation that was identified by whole-exome sequencing. The patient was found to have segmental uniparental disomy (UPD) of chromosome 15 explaining her diagnosis of Angelman syndrome. Whole-exome sequencing further revealed a novel homozygous intronic variant in CYP11A1, the gene encoding P450scc, found within the region of UPD. In vitro studies confirmed that this variant led to decreased efficiency of CYP11A1 splicing. We report the first case of the combination of 2 rare genetic disorders, Angelman syndrome, and P450scc deficiency. After 20 years of diagnostic efforts, significant advances in genetic diagnostic technology allowed us to determine that these 2 disorders originate from a unified genetic etiology, segmental UPD unmasking a novel recessive mutation in CYP11A1. © 2018 S. Karger AG, Basel.

  10. Ancient Artifacts vs. Digital Artifacts: New Tools for Unmasking the Sale of Illicit Antiquities on the Dark Web

    Directory of Open Access Journals (Sweden)

    Katie A. Paul

    2018-03-01

    Full Text Available Since the rise of the Islamic State of Iraq and Syria (ISIS, also known as Daesh and ISIL in 2014, antiquities have been a widely publicized source of funding for what has become one of the most technologically savvy terrorist organizations of the modern era. The globalization of technology and rise of popularity in cryptocurrencies has changed the face of black-market trade and the actors that carry out these crimes. While art and antiquities have long served as a market with susceptibilities to laundering, the emergence of Dark Web markets, identification-masking software, and untraceable cryptocurrencies such as Bitcoin have opened new doors to potential vulnerabilities. The anonymity that is offered by these technologies acts as a roadblock for authorities, while attracting the likes of terrorists and transnational criminals. Investigative research using cyber security platforms to identify digital artifacts connected to potential traffickers provides the opportunity to unmask the seemingly untraceable actors behind these activities. The evidence of illicit antiquities trafficking on the Dark Web displayed in this article can generate a new discussion on how and where to study black-market antiquities to gain needed insight into combating the illicit trade online and the transnational criminal groups it may finance.

  11. Detection of Occult Erythrocytic Membrane Damages upon Pharmacological Exposures

    Directory of Open Access Journals (Sweden)

    P. Yu. Alekseyeva

    2007-01-01

    Full Text Available Blood administration of pharmaceuticals may cause occult effects of these agents on erythrocytic membranes. These effects may damage and cause additional membrane defects, but may strengthen. The type and degree of the effects of an agent were detected by calibrated irreversible electroporation with a pulsed electric field (PEF. The paper considers the erythrocytic membranous effects of a wide concentration range of agents used in anesthesiology, such as esmerone, tracrium, and mar-caine-adrenaline. Under the action of PEF and esmerone at the normal concentration N, the rate of erythrocytic hemolysis increased by several times as compared with the control. The similar effect also occurred when esmerone was added at the concentration C=10N. Tracrium exerted a fixing effect on erythrocytic membranes. Upon a combined exposure to PEF and tracrium in the normal concentration C=N; erythrocytic hemolysis was slow. So was with the concentration C=10N. The rate of hemolysis of the red blood cells subjected to a combined action of marcaine adrenaline at the normal concentration C=N and even at the concentration C=10N and PEF was comparable with the hemolytic rate of the reference suspension. 

  12. Exploring atmospheric blocking with GPS radio occultation observations

    Directory of Open Access Journals (Sweden)

    L. Brunner

    2016-04-01

    Full Text Available Atmospheric blocking has been closely investigated in recent years due to its impact on weather and climate, such as heat waves, droughts, and flooding. We use, for the first time, satellite-based observations from Global Positioning System (GPS radio occultation (RO and explore their ability to resolve blocking in order to potentially open up new avenues complementing models and reanalyses. RO delivers globally available and vertically highly resolved profiles of atmospheric variables such as temperature and geopotential height (GPH. Applying a standard blocking detection algorithm, we find that RO data robustly capture blocking as demonstrated for two well-known blocking events over Russia in summer 2010 and over Greenland in late winter 2013. During blocking episodes, vertically resolved GPH gradients show a distinct anomalous behavior compared to climatological conditions up to 300 hPa and sometimes even further up into the tropopause. The accompanying increase in GPH of up to 300 m in the upper troposphere yields a pronounced tropopause height increase. Corresponding temperatures rise up to 10 K in the middle and lower troposphere. These results demonstrate the feasibility and potential of RO to detect and resolve blocking and in particular to explore the vertical structure of the atmosphere during blocking episodes. This new observation-based view is available globally at the same quality so that blocking in the Southern Hemisphere can also be studied with the same reliability as in the Northern Hemisphere.

  13. Occult radiological effects of lipomatosis of the lumbosacral plexus

    Energy Technology Data Exchange (ETDEWEB)

    Mahan, Mark A. [Barrow Neurological Institute, Phoenix, AZ (United States); Howe, B.M.; Amrami, Kimberly K. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Spinner, Robert J. [Mayo Clinic, Department of Neurosurgery, Rochester, MN (United States); Mayo Clinic, Department of Orthopedics, Rochester, MN (United States); Mayo Clinic, Rochester, MN (United States)

    2014-07-15

    Lipomatosis of nerve (LN) is a condition of massive peripheral nerve enlargement frequently associated with hypertrophy within the distribution of the nerve, and most commonly affecting the distal limbs. We sought to understand if LN of the lumbosacral plexus would be associated with the trophic effects of LN on surrounding tissue within the pelvis, which may be clinically occult, but present on MRI. Fifty-one cases of LN, confirmed by pathology or pathognomonic appearance on MRI, were reviewed. Patients with LN of the sciatic nerve were investigated for radiological signs suggestive of overgrowth. Five patients had involvement of the sciatic nerve, 4 of whom had MR imaging of the pelvis. Three patients had LN involving the lumbosacral plexus, and one patient had isolated involvement of the sciatic nerve. All patients with involvement of the lumbosacral plexus demonstrated previously unrecognized evidence of nerve territory overgrowth in the pelvis, including: LN, profound adipose proliferation, muscle atrophy and fatty infiltration, and bone hypertrophy and ankylosis. The patient with LN involving the intrapelvic sciatic nerve, but not the lumbosacral plexus did not demonstrate any radiological evidence of pelvic overgrowth. LN is broader in anatomical reach than previously understood. Proximal plexal innervation may be involved, with a consequent effect on axial skeleton and intrapelvic structures. (orig.)

  14. Cassini-VIMS at Jupiter: Solar occultation measurements using Io

    Science.gov (United States)

    Formisano, V.; D'Aversa, E.; Bellucci, G.; Baines, K.H.; Bibring, J.-P.; Brown, R.H.; Buratti, B.J.; Capaccioni, F.; Cerroni, P.; Clark, R.N.; Coradini, A.; Cruikshank, D.P.; Drossart, P.; Jaumann, R.; Langevin, Y.; Matson, D.L.; McCord, T.B.; Mennella, V.; Nelson, R.M.; Nicholson, P.D.; Sicardy, B.; Sotin, Christophe; Chamberlain, M.C.; Hansen, G.; Hibbits, K.; Showalter, M.; Filacchione, G.

    2003-01-01

    We report unusual and somewhat unexpected observations of the jovian satellite Io, showing strong methane absorption bands. These observations were made by the Cassini VIMS experiment during the Jupiter flyby of December/January 2000/2001. The explanation is straightforward: Entering or exiting from Jupiter's shadow during an eclipse, Io is illuminated by solar light which has transited the atmosphere of Jupiter. This light, therefore becomes imprinted with the spectral signature of Jupiter's upper atmosphere, which includes strong atmospheric methane absorption bands. Intercepting solar light refracted by the jovian atmosphere, Io essentially becomes a "miffor" for solar occultation events of Jupiter. The thickness of the layer where refracted solar light is observed is so large (more than 3000 km at Io's orbit), that we can foresee a nearly continuous multi-year period of similar events at Saturn, utilizing the large and bright ring system. During Cassini's 4-year nominal mission, this probing tecnique should reveal information of Saturn's atmosphere over a large range of southern latitudes and times. ?? 2003 Elsevier Inc. All rights reserved.

  15. Occult hepatitis B infection and transfusion-transmission risk.

    Science.gov (United States)

    Candotti, D; Boizeau, L; Laperche, S

    2017-09-01

    Advances in serology and viral nucleic acid testing (NAT) over the last decades significantly reduced the risk of transfusion-transmitted hepatitis B virus (HBV). The combination of HBsAg testing and NAT efficiently prevents the majority of HBV transmission. However, a specific residual risk remains associated with extremely low viral DNA levels in blood donors with occult HBV infection (OBI) that are intermittently or not detectable even by highly sensitive individual donation (ID) NAT. Studies have reported HBV transfusion-transmission with blood components from donors with OBI that contained low amount of viruses (transfusion-transmission seems to depend on a combination of several factors including the volume of plasma associated with the infected blood components transfused, the anti-HBV immune status of both recipient and donor, and possibly the viral fitness of the infecting HBV strain. Models based on clinical and experimental evidences estimate a residual transmission risk of 3-14% associated with OBI donations testing HBsAg and ID-NAT non-reactive. Anti-HBc testing has the potential to improve further blood safety but it may also compromise blood availability in settings with medium/high HBV prevalence. Pathogen reduction procedures might be considered. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  16. Ectoparasites of the occult bat, Myotis occultus (Chiroptera: Vespertilionidae)

    Science.gov (United States)

    Valdez, Ernest W.; Ritzi, Christopher M.; Whitaker, John O.

    2009-01-01

    Only a single previous study has examined ectoparasites of the occult bat (Myotis occultus), from which only 2 species of fleas were identified. For our study, we examined 202 individuals, 52 fresh hosts and 150 museum specimens, from New Mexico and southern Colorado for ectoparasites. We recorded 2158 ectoparasites, 634 from fresh hosts and 1524 from museum specimens. Ectoparasites belonged to 10 families and 13 genera of insect or acari and represent new host and locality records. In general, ectoparasites collected from fresh hosts and museum specimens were represented by 4 major species of mite: Macronyssus crosbyi, Alabidocarpus calcaratus, Acanthophthirius lucifugus, and Alabidocarpus nr. eptesicus. From our study, we found fresh hosts to have significantly greater prevalence values for Myodopsylla gentilis (flea), Chiroptonyssus robustipes (mite), and Leptotrombidium myotis (chigger), whereas museum specimens had significantly greater prevalence values for A. calcaratus(mite) and A. nr. eptesicus (mite). There were no significant differences between prevalence values for 4 mites including M. crosbyi, A. lucifugus, Pteracarus nr. minutus, and Cryptonyssussp. Our study represents the only extensive study of ectoparasites on M. occultus and provides evidence for the importance of examining fresh hosts and museum specimens in future ectoparasite studies.

  17. MRI of occult sacral insufficiency fractures following radiotherapy

    International Nuclear Information System (INIS)

    Mammone, J.F.; Schweitzer, M.E.

    1995-01-01

    Following radiation therapy, marrow abnormalities noted on magnetic resonance imaging (MRI) are frequent and may mimic metastases. Specific radiotherapy changes are usually easily identifiable; however, traumatic lesions cause more interpretive difficulties. We assessed the incidence and MRI characteristics of insufficiency fractures in this population. During a 5-year span (1987-1991), 546 patients received pelvic radiotherapy for primary malignancies. MRI was performed in 25 of these patients at least 3 months after treatment. The mean dose in this group was 53 Gy. These MRI scans were retrospectively reviewed for the appearance of the sacrum with particular attention to the presence of insufficiency fractures. This was correlated with clinical course and scintigraphic findings. Presumed insufficiency fractures on MRI paralleled the sacral side of the sacroiliac joint, enhanced with Gd-DTPA, were most prominent or initially seen anteriorly, and had ill-defined margins on all imaging sequences. The incidence of occult sacral insufficiency fractures was at least 20%. Insufficiency fractures of the sacrum in the post-radiotherapy patient are a relatively frequent occurrence which can mimic metastases. Consideration of this phenomenon and knowledge of differential features may avoid overdiagnosis of osseous metastases. (orig.)

  18. Atmospheric diurnal variations observed with GPS radio occultation soundings

    Directory of Open Access Journals (Sweden)

    F. Xie

    2010-07-01

    Full Text Available The diurnal variation, driven by solar forcing, is a fundamental mode in the Earth's weather and climate system. Radio occultation (RO measurements from the six COSMIC satellites (Constellation Observing System for Meteorology, Ionosphere and Climate provide nearly uniform global coverage with high vertical resolution, all-weather and diurnal sampling capability. This paper analyzes the diurnal variations of temperature and refractivity from three-year (2007–2009 COSMIC RO measurements in the troposphere and stratosphere between 30° S and 30° N. The RO observations reveal both propagating and trapped vertical structures of diurnal variations, including transition regions near the tropopause where data with high vertical resolution are critical. In the tropics the diurnal amplitude in refractivity shows the minimum around 14 km and increases to a local maximum around 32 km in the stratosphere. The upward propagating component of the migrating diurnal tides in the tropics is clearly captured by the GPS RO measurements, which show a downward progression in phase from stratopause to the upper troposphere with a vertical wavelength of about 25 km. At ~32 km the seasonal variation of the tidal amplitude maximizes at the opposite side of the equator relative to the solar forcing. The vertical structure of tidal amplitude shows strong seasonal variations and becomes asymmetric along the equator and tilted toward the summer hemisphere in the solstice months. Such asymmetry becomes less prominent in equinox months.

  19. Assimilation of GNSS radio occultation observations in GRAPES

    Science.gov (United States)

    Liu, Y.; Xue, J.

    2014-07-01

    This paper reviews the development of the global navigation satellite system (GNSS) radio occultation (RO) observations assimilation in the Global/Regional Assimilation and PrEdiction System (GRAPES) of China Meteorological Administration, including the choice of data to assimilate, the data quality control, the observation operator, the tuning of observation error, and the results of the observation impact experiments. The results indicate that RO data have a significantly positive effect on analysis and forecast at all ranges in GRAPES not only in the Southern Hemisphere where conventional observations are lacking but also in the Northern Hemisphere where data are rich. It is noted that a relatively simple assimilation and forecast system in which only the conventional and RO observation are assimilated still has analysis and forecast skill even after nine months integration, and the analysis difference between both hemispheres is gradually reduced with height when compared with NCEP (National Centers for Enviromental Prediction) analysis. Finally, as a result of the new onboard payload of the Chinese FengYun-3 (FY-3) satellites, the research status of the RO of FY-3 satellites is also presented.

  20. Information content in reflected signals during GPS Radio Occultation observations

    Science.gov (United States)

    Aparicio, Josep M.; Cardellach, Estel; Rodríguez, Hilda

    2018-04-01

    The possibility of extracting useful information about the state of the lower troposphere from the surface reflections that are often detected during GPS radio occultations (GPSRO) is explored. The clarity of the reflection is quantified, and can be related to properties of the surface and the low troposphere. The reflected signal is often clear enough to show good phase coherence, and can be tracked and processed as an extension of direct non-reflected GPSRO atmospheric profiles. A profile of bending angle vs. impact parameter can be obtained for these reflected signals, characterized by impact parameters that are below the apparent horizon, and that is a continuation at low altitude of the standard non-reflected bending angle profile. If there were no reflection, these would correspond to tangent altitudes below the local surface, and in particular below the local mean sea level. A forward operator is presented, for the evaluation of the bending angle of reflected GPSRO signals, given atmospheric properties as described by a numerical weather prediction system. The operator is an extension, at lower impact parameters, of standard bending angle operators, and reproduces both the direct and reflected sections of the measured profile. It can be applied to the assimilation of the reflected section of the profile as supplementary data to the direct section. Although the principle is also applicable over land, this paper is focused on ocean cases, where the topographic height of the reflecting surface, the sea level, is better known a priori.

  1. SOLAR OCCULTATION BY TITAN MEASURED BY CASSINI/UVIS

    Energy Technology Data Exchange (ETDEWEB)

    Capalbo, Fernando J.; Benilan, Yves [Laboratoire Interuniversitaire des Systemes Atmospheriques (LISA), UMR 7583 du CNRS, Universites Paris Est Creteil (UPEC) and Paris Diderot - UPD, 61 avenue du General de Gaulle, 94010 Creteil Cedex (France); Yelle, Roger V.; Koskinen, Tommi T.; Sandel, Bill R. [Lunar and Planetary Laboratory, University of Arizona, 1629 E. University Blvd., Tucson, AZ 85721 (United States); Holsclaw, Gregory M.; McClintock, William E., E-mail: fernando.capalbo@lisa.u-pec.fr [Laboratory for Atmospheric and Space Physics, University of Colorado, 3665 Discovery Drive, Boulder, CO 80303 (United States)

    2013-04-01

    We present the first published analysis of a solar occultation by Titan's atmosphere measured by the Ultraviolet Imaging Spectrograph on board Cassini. The data were measured during flyby T53 in 2009 April and correspond to latitudes between 21 Degree-Sign and 28 Degree-Sign south. The analysis utilizes the absorption of two solar emission lines (584 A and 630 A) in the ionization continuum of the N{sub 2} absorption cross section and solar emission lines around 1085 A where absorption is due to CH{sub 4}. The measured transmission at these wavelengths provides a direct estimate of the N{sub 2} and CH{sub 4} column densities along the line of sight from the spacecraft to the Sun, which we inverted to obtain the number densities. The high signal-to-noise ratio of the data allowed us to retrieve density profiles in the altitude range 1120-1400 km for nitrogen and 850-1300 km for methane. We find an N{sub 2} scale height of {approx}76 km and a temperature of {approx}153 K. Our results are in general agreement with those from previous work, although there are some differences. Particularly, our profiles agree, considering uncertainties, with the density profiles derived from the Voyager 1 Ultraviolet Spectrograph data, and with in situ measurements by the Ion Neutral Mass Spectrometer with revised calibration.

  2. The value of MR imaging of PDFASAT sequence in the diagnosis of extremities occult fractures

    International Nuclear Information System (INIS)

    Lu Lingquan; Xu Mingshen; Wu Qianzhi; Mao Chunnan; Wang Shuzi; Zhou Xingfan; Wang Liping

    2004-01-01

    Objective: To investigate the value of MR imaging of proton density weighted-fat saturated (PDFASAT) sequence in detecting the occult fracture of extremities. Methods: Thirty-one patients with acute trauma were studied using radiography and MR imaging within 45 days. MR sequences included FSE T 1 WI, T 2 WI, and PDFASAT. 21 occult fractures occurred in the knee joint, 6 in the hip joint, 1 in the elbow joint, 2 in the shoulder, and 1 in the ankle. Results: All 31 cases had normal radiographic results. 10 cases with proximal fibula, 4 with proximal tibia and 7 with femur condyle occult fractures were found in 21 knee joint acute trauma cases. 2 cases with intertrochanteric, 2 with femoral neck and 2 with cotyle occult fractures were found in 6 hip joint trauma cases. 2 proximal humerus occult fractures were found in 2 shoulder cases. 1 distal humerus and 1 distal fibula occult fracture was found in elbow and ankle cases. MR imaging demonstrated irregular linear low signal in the subcortical region on both T 1 WI and T 2 WI, and high signal changes around low signal were seen on T 2 WI in some cases. The high signal in PDFASAT sequence was more remarkable and wider than that on both T 1 WI and T 2 WI. Conclusion: MR imaging could determine the diagnosis of acute and chronic occult fractures. MRI should be the next choice when plain films fail to reveal suspected fractures in setting of suggestive symptoms and positive physical examination. PDFASAT would be the best effective sequence among the T 1 WI, T 2 WI, and PDFASAT. (author)

  3. Recurring sets of recurring starspot occultations on exoplanet host Qatar-2

    Science.gov (United States)

    Močnik, T.; Southworth, J.; Hellier, C.

    2017-10-01

    We announce the detection of recurring sets of recurring starspot occultation events in the short-cadence K2 light curve of Qatar-2, a K dwarf star transited every 1.34 d by a hot Jupiter. In total, we detect 34 individual starspot occultation events, caused by five different starspots, occulted in up to five consecutive transits or after a full stellar rotation. The longest recurring set of recurring starspot occultations spans over three stellar rotations, setting a lower limit for the longest starspot lifetime of 58 d. Starspot analysis provided a robust stellar rotational period measurement of 18.0 ± 0.2 d and indicates that the system is aligned, having a sky-projected obliquity of 0° ± 8°. A pronounced rotational modulation in the light curve has a period of 18.2 ± 1.6 d, in agreement with the rotational period derived from the starspot occultations. We tentatively detect an ellipsoidal modulation in the phase curve, with a semi-amplitude of 18 ppm, but cannot exclude the possibility that this is the result of red noise or imperfect removal of the rotational modulation. We detect no transit-timing and transit-duration variations with upper limits of 15 s and 1 min, respectively. We also reject any additional transiting planets with transit depths above 280 ppm in the orbital period region 0.5-30 d.

  4. Retrieval of Electron Density Profile for KOMPSAT-5 GPS Radio Occultation

    Directory of Open Access Journals (Sweden)

    Woo-Kyoung Lee

    2007-12-01

    Full Text Available The AOPOD (Atmosphere Occultation and Precision Orbit Determination system, the secondary payload of KOMPSAT (KOrea Multi-Purpose SATellite-5 scheduled to be launched in 2010, shall provide GPS radio occultation data. In this paper, we simulated the GPS radio occultation characteristic of KOMPSAT-5 and retrieved electron density profiles using KROPS (KASI Radio Occultation Processing Software. The electron density retrieved from CHAMP (CHAllenging Minisatellite Payload GPS radio occultation data on June 20, 2004 was compared with IRI (International Reference Ionosphere - 2001, PLP (Planar Langmuir Probe, and ionosonde measurements. When the result was compared with ionosonde measurements, the discrepancies were 5 km on the F_2 peak height (hmF_2 and 3×10^{10} el/m^3 on the electron density of the F_2 peak height (NmF_2. By comparing with the Langmuir Probe measurements of CHAMP satellite (PLP, both agrees with 1.6×10^{11} el/m^3 at the height of 365.6 km.

  5. [Surgical Diagnosis and Treatment of Primary Hyperthyroidism Complicated with Occult Thyroid Carcinoma].

    Science.gov (United States)

    Wu, Xin; Yu, Jian-chun; Kang, Wei-ming; Ma, Zhi-qiang; Ye, Xin

    2015-08-01

    To evaluate the surgical diagnosis and treatment of primary hyperthyroidism complicated with occult thyroid carcinoma. Data of 51 cases of primary hyperthyroidism complicated with occult thyroid carcinoma admitted during January 2004 to November 2014 were analyzed retrospectively. The incidence of occult thyroid carcinoma was 5.03% in hyperthyroidism,and 47 cases (92.16%) were female. The preoperative diagnosis of all these 51 cases was primary hyperthyroidism and 11 cases were diagnosed thyroid carcinoma at the same time;25 cases were diagnosed thyroid carcinoma by frozen section and the remaining 26 cases were diagnosed by postoperative pathology. Finally,26 cases underwent subtotal thyroidectomy,4 cases underwent total thyroidectomy, and 21 cases underwent total thyroidectomy with lymphadenectomy. The tumor size ranged from 0.1 to 1.0 cm [mean:(0.63 ± 0.35) cm]. The lesions were less than or equal to 0.5 cm in 28 cases (54.9%). The follow-up lasted from 1 to 121 months [mean:(28.6 ± 22.7)months] in 43 patients,and all of them survived. Primary hyperthyroidism complicated with occult thyroid carcinoma is commonly found in female patients. Preoperative diagnosis is difficult. Ultrasound is the major examining method. Frozen section can increase the detection rate. The postoperative prognosis of hyperthyroidism complicated with occult thyroid carcinoma is satisfactory.

  6. Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece

    Science.gov (United States)

    Mina, Paraskevi; Georgiadou, Sarah P; Rizos, Christos; Dalekos, George N; Rigopoulou, Eirini I

    2010-01-01

    AIM: To assess the hepatitis B virus (HBV)-DNA and the prevalence of occult HBV infection in end-stage renal failure (ESRF) patients from Central Greece. METHODS: Sera from 366 ESRF patients attending five out of six dialysis units from Central Greece were investigated for HBV-DNA by real-time polymerase chain reaction. Only serum samples with repeatedly detectable HBV-DNA were considered positive. IgG antibodies to hepatitis C virus (anti-HCV) were tested by a third generation enzyme linked immunosorbent assay (ELISA), while IgG antibodies to hepatitis E virus (anti-HEV) were tested by two commercially available ELISAs. RESULTS: HBV-DNA was detected in 15/366 patients (4.1%) and HBsAg in 20/366 (5.5%). The prevalence of occult HBV infection was 0.9% (3/346 HBsAg-negative patients). Occult HBV was not associated with a specific marker of HBV infection or anti-HCV or anti-HEV reactivity. There was no significant difference in HBV-DNA titres, demographic and biochemical features, between patients with occult HBV infection and those with HBsAg-positive chronic HBV infection. CONCLUSION: In central Greece, 4% of ESRF patients had detectable HBV-DNA, though in this setting, the prevalence of occult HBV seems to be very low (0.9%). PMID:20066742

  7. Outcome of Concurrent Occult Hemothorax and Pneumothorax in Trauma Patients Who Required Assisted Ventilation

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    Ismail Mahmood

    2015-01-01

    Full Text Available Background. The management and outcomes of occult hemopneumothorax in blunt trauma patients who required mechanical ventilation are not well studied. We aimed to study patients with occult hemopneumothorax on mechanical ventilation who could be carefully managed without tube thoracostomy. Methods. Chest trauma patients with occult hemopneumothorax who were on mechanical ventilation were prospectively evaluated. The presence of hemopneumothorax was confirmed by CT scanning. Hospital length of stay, complications, and outcome were recorded. Results. A total of 56 chest trauma patients with occult hemopneumothorax who were on ventilatory support were included with a mean age of 36 ± 13 years. Hemopneumothorax was managed conservatively in 72% cases and 28% underwent tube thoracostomy as indicated. 29% of patients developed pneumonia, 16% had Acute Respiratory Distress Syndrome (ARDS, and 7% died. Thickness of hemothorax, duration of mechanical ventilation, and development of ARDS were significantly associated with tube thoracostomy in comparison to no-chest tube group. Conclusions. The majority of occult hemopneumothorax can be carefully managed without tube thoracostomy in patients who required positive pressure ventilation. Tube thoracotomy could be restricted to those who had evidence of increase in the size of the hemothorax or pneumothorax on follow-up chest radiographs or developed respiratory compromise.

  8. [Prevalence of occult hepatitis B virus infection and its phylogenetic features among mother-teenager pairs].

    Science.gov (United States)

    Dong, Xiao-lian; Yao, Qing-qing; Wang, Xue-cai; Xu, Hai-tao; Wang, Xiao-li; Chen, Sheng-yu; Tang, Zhi-feng; Zheng, Ying-Jie

    2013-03-01

    Prevalence of occult hepatitis B virus (HBV) infection (OBI) was investigated in a paired mother-teenager population and HBV S gene variation including overt and occult HBV, was determined. A follow-up study based on an initial survey of 135 mother-teenager pairs was carried out through collection of questionnaires and blood samples HBsAg were detected by ELISA method, viral load by PCR amplification and HBV S gene by phylogenetic analysis. 102 pairs of subjects were followed-up. Blood samples from 94 mothers and 101 children were collected. OBI prevalence in mothers was 10.0% (6/60), significantly higher than 2.0% (2/101) in teenagers. Medians of viral load were 399.9 IU/ml and 247.6 IU/ml in overt and occult HBV strains, but without significant difference. 1 occult HBV strain belonged to genotype B with serotype adw while the other 7 were genotype C with serotype adr. 15 of the overt HBV strains belonged to genotype B with serotype adw and the other 8 were genotype C with serotype adr. Proportions of genotype-C strains were significantly higher in occult HBV strains than in overt HBV strains. OBI was seen in teenage-mother population.

  9. Disparities in the receipt of fecal occult blood test versus endoscopy among Filipino American immigrants.

    Science.gov (United States)

    Maxwell, Annette E; Danao, Leda L; Crespi, Catherine M; Antonio, Cynthia; Garcia, Gabriel M; Bastani, Roshan

    2008-08-01

    This report examines disparities associated with the type of colorectal screening test, fecal occult blood test versus endoscopy, within a particular racial/ethnic group, Filipino American immigrants. Between July 2005 and October 2006, Filipino Americans aged 50 to 75 years from 31 community organizations in Los Angeles completed a 15-minute survey in English (65%) or Filipino (35%). Of the 487 respondents included in this analysis, 257 (53%) had never received any type of colorectal cancer screening. Among the 230 subjects who had ever received a routine screening test, 78 had fecal occult blood test only (16% of the total sample), and 152 had endoscopy with or without fecal occult blood test (31% of the total sample). After controlling for access to care and key demographic variables in a multivariate analysis, only two characteristics distinguished between respondents who had fecal occult blood test only versus those who had endoscopy: acculturation, assessed by percent lifetime in the United States and language of interview, and income. Our data suggest a two-tier system, fecal occult blood test for less acculturated Filipino Americans with lower income versus endoscopy for Filipino immigrants with higher levels of acculturation and income. The disparity persists after adjusting for access to care. Instead of treating minority groups as monolithic, differences within groups need to be examined so that interventions can be appropriately targeted.

  10. Optimization of the occulter for the Solar Orbiter/METIS coronagraph

    Science.gov (United States)

    Landini, Federico; Vivès, Sébastien; Romoli, Marco; Guillon, Christophe; Pancrazzi, Maurizio; Escolle, Clement; Focardi, Mauro; Antonucci, Ester; Fineschi, Silvano; Naletto, Giampiero; Nicolini, Gianalfredo; Nicolosi, Piergiorgio; Spadaro, Daniele

    2012-09-01

    METIS (Multi Element Telescope for Imaging and Spectroscopy investigation), selected to fly aboard the Solar Orbiter ESA/NASA mission, is conceived to perform imaging (in visible, UV and EUV) and spectroscopy (in EUV) of the solar corona, by means of an integrated instrument suite located on a single optical bench and sharing the same aperture on the satellite heat shield. As every coronagraph, METIS is highly demanding in terms of stray light suppression. Coronagraphs history teaches that a particular attention must be dedicated to the occulter optimization. The METIS occulting system is of particular interest due to its innovative concept. In order to meet the strict thermal requirements of Solar Orbiter, METIS optical design has been optimized by moving the entrance pupil at the level of the external occulter on the S/C thermal shield, thus reducing the size of the external aperture. The scheme is based on an inverted external-occulter (IEO). The IEO consists of a circular aperture on the Solar Orbiter thermal shield. A spherical mirror rejects back the disk-light through the IEO. A breadboard of the occulting assembly (BOA) has been manufactured in order to perform stray light tests in front of two solar simulators (in Marseille, France and in Torino, Italy). A first measurement campaign has been carried on at the Laboratoire d'Astrophysique de Marseille. In this paper we describe the BOA design, the laboratory set-up and the preliminary results.

  11. Unmasked adult-onset urea cycle disorders in the critical care setting.

    Science.gov (United States)

    Summar, Marshall L; Barr, Frederick; Dawling, Sheila; Smith, Wendy; Lee, Brendan; Singh, Rani H; Rhead, William J; Sniderman King, Lisa; Christman, Brian W

    2005-10-01

    Most often, urea cycle disorders have been described as acute onset hyperammonemia in the newborn period; however, there is a growing awareness that urea cycle disorders can present at almost any age, frequently in the critical care setting. This article presents three cases of adult-onset hyperammonemia caused by inherited defects in nitrogen processing in the urea cycle, and reviews the diagnosis, management, and pathophysiology of adult-onset urea cycle disorders. Individuals who have milder molecular urea cycle defects can lead a relatively normal life until a severe environmental stress triggers a hyperammonemic crisis. Comorbid conditions such as physical trauma often delay the diagnosis of the urea cycle defect. Prompt recognition and treatment are essential in determining the outcome of these patients.

  12. The Return of Congenital Rickets, Are We Missing Occult Cases?

    Science.gov (United States)

    Elidrissy, Abdelwahab T H

    2016-09-01

    Congenital rickets is the term given to fetus born with clinical features of rickets, but those born with biochemical evidence of rickets without obvious clinical features still can be considered occult congenital rickets. Some of the affected babies with this disease have the intrauterine rachitic environment, but a calcium trans-placental pump prevents the fetus from having clinical features of rickets. They may present with hypocalcemia few days after birth or later with more florid features of rickets. Congenital rickets cases born with florid features reported over the last 40 years are few and can be divided into two groups. The first due to severe maternal osteomalacia in which their bones were so decalcified to have enough calcium to be pumped to their fetus. Another group in which newborn babies were hypocalcemic due to other maternal diseases as malabsorption, celiac disease, pre-eclampsia, and prematurity. All inherited rickets cases per se, or as part of other syndromes can be considered congenital rickets. Most cases seen in our region are due to maternal vitamin D deficiency with symptoms becoming obvious when the infants are breastfed, or may present with hypocalcemic convulsions or craniotabes. This is a review of congenital rickets with the aim of shedding light on this potentially acute disease that needs more attention and awareness in the neonatal period to avoid rare serious complications as cardiomyopathy or myelofibrosis and the complications of hypocalcemic convulsions. Congenital rickets cases seen simulate a tip of an ice-burg and its prevention is an important issue, especially with the tremendous urbanization with tall buildings living in sun-deprived flats as the commonest type of residence leading to the increasing incidence of maternal osteomalacia and rickets.

  13. Clues to occult cancer in patients with ischemic stroke.

    Directory of Open Access Journals (Sweden)

    Suk Jae Kim

    Full Text Available BACKGROUND: We hypothesized that hidden malignancy could be detected in patients with cryptogenic stroke without active cancer when they showed the distinctive characteristics of cancer-related stroke. METHODS AND FINDINGS: Among 2,562 consecutive patients with acute ischemic stroke, patients with cryptogenic stroke were analyzed and categorized into two groups according to the presence of active cancer: cryptogenic stroke with active cancer (cancer-related stroke, CA-stroke group and without active cancer (CR-stroke group. Patients with active lung cancer without stroke were also recruited for comparison purposes (CA-control. Clinical factors, lesion patterns on diffusion-weighted MRI (DWI, and laboratory findings were analyzed among groups. A total of 348 patients with cryptogenic stroke were enrolled in this study. Among them, 71 (20.4% patients had active cancer at the time of stroke. The D-dimer levels were significantly higher in patients with CA-stroke than those with CR-stroke or CA-control (both p<0.001. Regarding lesion patterns, patients with CA-stroke mostly had multiple lesions in multiple vascular territories, while more than 80% of patients with CR-stroke had single/multiple lesions in a single vascular territory (P<0.001. D-dimer levels (OR 1.11 per 1 µg/mL increase; 95% CI 1.06-1.15; P<0.001 and DWI lesion patterns (OR 7.13; 95% CI 3.42-14.87; P<0.001 were independently associated with CA-stroke. Workup for hidden malignancy was performed during hospitalization in 10 patients who showed elevated D-dimer levels and multiple infarcts involving multiple vascular territories but had no known cancer, and it revealed hidden malignancies in all the patients. CONCLUSION: Patients with CA-stroke have distinctive D-dimer levels and lesion patterns. These characteristics can serve as clues to occult cancer in patients with cryptogenic stroke.

  14. Clinical presentations and MRI findings of angiographically occult vascular malformations

    International Nuclear Information System (INIS)

    Kida, Yoshihisa; Kobayashi, Tatsuya; Tanaka, Takayuki; Oyama, Hirofumi; Iwakoshi, Takayasu

    1994-01-01

    Various clinical features as well as MRI findings of AOVM (angiographically occult vascular malformation) were studied. Amongst out patients, since January 1988, there have been 30 cases of symptomatic AOVM (20 males, 10 females) including 4 cases with multiple lesions. The age ranged from 3 to 60 years of age, with a mean of 33.4 years. The locations of symptomatic lesions were in the cerebral hemisphere (15), the thalamus (4), the brain stem (8) and in the cerebellum (3). The initial presentations of these 30 cases were either by hemorrhage (18), convulsive seizure (9) or by progressive neurological deficits (3). The initial presentation was not related to the patient's age and the size of the lesion, but apparently related to the location of AOVM. Most of the lesions in the cerebral hemisphere presented seizures, but all of the lesions in the thalamus, the brain stem and the cerebellum disclosed hemorrhage as an initial presentation. In fact it was noticed that brain stem lesions tend to cause repetitive hemorrhage in a relatively short period. AOVM lesions were clearly visualized with T2-weighted MRI images, consisting of high intensity cores with surrounding low intensity rims. Most of the symptomatic lesions were partially enhanced by Gd-DTPA with varied intensity. Dynamic changes in size and enhancement pattern on MRI were occasionally seen, usually accompanied with episodes such as hemorrhage or neurological deterioration. Although AOVMs were angiographically negative some strands indicating draining veins were observed on MRI in several cases. In contrast, none of the nonsymptomatic lesions (22 lesions) demonstrated enhancement effects with Gd-DTPA. (author)

  15. Occult hepatitis B infection in children with chronic liver disease.

    Science.gov (United States)

    Srivastava, Anshu; Mathias, Amrita; Yachha, Surender K; Aggarwal, Rakesh

    2015-04-01

    Occult hepatitis B infection (OBI) may adversely affect the outcome of patients with chronic liver disease (CLD). There are no data on OBI and CLD in children. This study determined the prevalence and effect of OBI in HBsAg-negative CLD children. CLD children were prospectively evaluated with a demographic, clinical, and investigative proforma. All HBsAg-negative CLD cases were tested for exposure to hepatitis B (total anti-HBc, anti-HBs). Serum hepatitis B virus DNA was measured in exposed (total anti-HBc positive) patients. A total of 115 HBsAg-negative CLD children (59 boys, age 9.0±3.6 years) were enrolled. The etiology of CLD was known in 94 cases and 21 children had cryptogenic CLD. Of these, 45 (39.1%) had evidence of HBV exposure (23 total anti-HBc positive, 17 total anti-HBc and anti-HBs positive, five only anti-HBs positive without previous vaccination). The anti-HBc-positive children had a higher Child's score than the anti-HBc-negative children [11 (5-13) vs. 7 (5-13); P=0.00]. A total of 4/45 children had seropositive OBI with serum HBV DNA of 8, 36, 133, and 156 IU/ml, respectively. The proportion of total anti-HBc positivity (8/21 vs. 32/94; P=0.8) and OBI (2/21 vs. 2/94; P=0.1) was similar in cryptogenic CLD and known cause CLD. Seropositive OBI is infrequent in Indian children with CLD. The prevalence is similar in cryptogenic and CLD of known etiology.

  16. TWENTY-FIVE SUBARCSECOND BINARIES DISCOVERED BY LUNAR OCCULTATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Richichi, A. [National Astronomical Research Institute of Thailand, 191 Siriphanich Bldg., Huay Kaew Rd., Suthep, Muang, Chiang Mai 50200 (Thailand); Fors, O. [Departament Astronomia i Meteorologia and Institut de Ciencies del Cosmos (ICC), Universitat de Barcelona (UB/IEEC), Marti i Franques 1, E-08028 Barcelona (Spain); Cusano, F. [INAF-Osservatorio Astronomico di Bologna, Via Ranzani 1, I-40127 Bologna (Italy); Moerchen, M., E-mail: andrea4work@gmail.com [European Southern Observatory, Casilla 19001, Santiago 19 (Chile)

    2013-09-15

    We report on 25 subarcsecond binaries, detected for the first time by means of lunar occultations in the near-infrared (near-IR) as part of a long-term program using the ISAAC instrument at the ESO Very Large Telescope. The primaries have magnitudes in the range K = 3.8-10.4, and the companions in the range K = 6.4-12.1. The magnitude differences have a median value of 2.8, with the largest being 5.4. The projected separations are in the range 6-748 mas and with a median of 18 mas, or about three times less than the diffraction limit of the telescope. Among our binary detections are a pre-main-sequence star and an enigmatic Mira-like variable previously suspected to have a companion. Additionally, we quote an accurate first-time near-IR detection of a previously known wider binary. We discuss our findings on an individual basis as far as made possible by the available literature, and we examine them from a statistical point of view. We derive a typical frequency of binarity among field stars of Almost-Equal-To 10%, in the resolution and sensitivity range afforded by the technique ( Almost-Equal-To 0.''003 to Almost-Equal-To 0.''5, and K Almost-Equal-To 12 mag, respectively). This is in line with previous results using the same technique but we point out interesting differences that we can trace up to sensitivity, time sampling, and average distance of the targets. Finally, we discuss the prospects for further follow-up studies.

  17. Occult carcinoma discovered after simple hysterectomy treated with postoperative radiotherapy

    International Nuclear Information System (INIS)

    Crane, Christopher H.; Schneider, Bernard F.

    1999-01-01

    Purpose: Treatment of patients with occult carcinoma of the cervix discovered after simple hysterectomy is controversial. The purpose of this review is to examine our results with postoperative radiotherapy and to compare them to similar reports and to reports of treatment with radical parametrectomy. Methods and Materials: Between November 1979 and April:, 18 patients were treated with radiotherapy at the University of Virginia for invasive carcinoma of the cervix discovered after simple hysterectomy. Simple hysterectomy was performed in all 18 patients for a variety of indications. After surgery gross residual carcinoma remained in four patients; and microscopic disease was present at the surgical margins in two patients. The remaining patients had no evidence of residual disease. All 18 patients had postoperative radiotherapy with or without brachytherapy. The endpoints for this study were local control, survival, and treatment-related toxicity. Actuarial rates were calculated using the Life method. Results: Median follow-up for all 18 patients was 42 months (range 2-202 months). Both the 5 and the 10-year actuarial local control rates were 88%. Five and 10-year actuarial overall survival rates were both 93%. Two patients had both local and distant cancer recurrences. There were no recurrences among the six patients treated with external beam alone. The remaining patients are all alive without evidence of disease, including two patients who had gross residual disease after surgery, and one patient with both microscopic positive margin and a positive lymph node (the only patient to undergo lymph node sampling). There was no severe acute morbidity and only one patient had severe late morbidity. Conclusions: Invasive carcinoma found after simple hysterectomy may be treated safely and effectively with postoperative radiotherapy. Patients with known residual disease following surgery do poorly with either radiotherapy or reoperation, but treatment with radiotherapy

  18. [MRI findings and pathological features of occult breast cancer].

    Science.gov (United States)

    Zhang, J J; Yang, X T; Du, X S; Zhang, J X; Hou, L N; Niu, J L

    2018-01-23

    Objective: To investigate the magnetic resonance imaging (MRI) findings and clinicopathological features of primary lesions in patients with occult breast cancer (OBC). Methods: The imaging reports from the Breast Imaging Reporting and Data System in 2013 were retrospectively analyzed to investigate the morphology and the time signal intensity curve (TIC) of breast lesions in patients with OBC. The clinical and pathological characteristics of these patients were also included. Results: A total of 34 patients were enrolled. Among these patients, 24 patients underwent modified radical mastectomy and 18 of them had primary breast carcinoma in pathological sections. MRI detected 17 cases of primary lesions, including six masse lesions with a diameter of 0.6-1.2 cm (average 0.9 cm), and 11 non-mass lesions with four linear distributions, three segmental distributions, three focal distributions, and one regions distribution. Five patients had TIC typeⅠprimary lesions, ten had TIC type Ⅱ primary lesions, and two had TIC type Ⅲ primary lesions. Among all 34 cases, 23 of them had complete results of immunohistochemistry: 11 estrogen receptor (ER) positive lesions (47.8%), tenprogesterone receptor (PR) positive lesions (43.5%), seven human epidermal growth factor receptor 2 (HER-2) positive lesions (30.4%), and 20high expression(>14%) of Ki-67 (87.0%). The proportion of type luminal A was 4.3%, type luminal B was 43.5%, triple negative breast cancer (TNBC) was 30.4%, and HER-2 over expression accounted for 21.7%. Conclusions: The primary lesions of OBC usually manifested as small mass lesions, or focal, linear or segmental distribution of non-mass lesions. The positive rate of ER and PR was low, but the positive rate of HER-2 and the proliferation index of Ki-67 was high. Type luminal B is the most common molecular subtype.

  19. Waves in Saturn's rings probed by radio occultation

    International Nuclear Information System (INIS)

    Rosen, P.A.

    1989-01-01

    Thirty wave features, observed in 3.6 and 13 cm-wavelength optical depth profiles of Saturn's rings obtained by Voyager 1 radio occultation, are analyzed individually and comparatively. Many are the signature of spiral density waves and bending waves excited by gravitational resonances with Saturn's satellites. A new technique for locating waveform extrema, which fits a sinusoid to each half cycle of wave data, quantifies the wavelength variation across a feature. Fitting dispersion models to the derived wavelengths provides new estimates of ambient surface mass density σ in each wave region. For fourteen weak density waves in Ring A, modelling of the waveform near resonance with linear density wave theory gives independent estimates of σ, as well as reliable estimates of resonance location. Measurements of wave amplitude damping give an upper bound for ring thickness 2H, where H is the ring scale height. In the wave regions studied, Rings A, B, and C have 30 approx-lt σ approx-lt 70, σ approx-gt 65, and σ ∼ 1 g/cm 2 , respectively. Mass loading estimates from waveform modelling are 20 to 40% larger than dispersion-derived values, suggesting accumulation of mass in the wave regions. The average offset of derived wave location from theoretical resonance is about 1 km. Model waveforms of overlapping waves excited by the satellites Janus and Epimethenus agree well with observed morphologies in the linear region near resonance. In Ring C, dispersion analysis indicates that the most prominent wave feature, previously unidentified, is a one-armed spiral wave

  20. Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses

    Directory of Open Access Journals (Sweden)

    Wendy K Adams

    2013-08-01

    Full Text Available Antagonism of N-methyl-D-aspartate (NMDA receptors by phencyclidine is thought to underlie its ability to induce a schizophrenia-like syndrome in humans, yet evidence indicates it has a broader pharmacological profile. Our previous lesion studies highlighted a role for serotonergic projections from the median, but not dorsal, raphe nucleus in mediating the hyperlocomotor effects of phencyclidine, without changing the action of the more selective NMDA receptor antagonist, MK-801. Here we compared locomotor responses to phencyclidine and MK 801 in rats that were administered 5,7 dihydroxytryptamine (5,7-DHT into either the dorsal or ventral hippocampus, which are preferentially innervated by median and dorsal raphe, respectively. Dorsal hippocampus lesions potentiated phencyclidine-induced hyperlocomotion (0.5, 2.5 mg/kg, but not the effect of MK-801 (0.1 mg/kg. Ventral hippocampus lesions did not alter the hyperlocomotion elicited by either compound. Given that phencyclidine and MK-801 may induce different spatiotemporal patterns of locomotor behavior, together with the known role of the dorsal hippocampus in spatial processing, we also assessed whether the 5,7-DHT-lesions caused any qualitative differences in locomotor responses. Treatment with phencyclidine or MK-801 increased the smoothness of the path travelled (reduced spatial d and decreased the predictability of locomotor patterns within the chambers (increased entropy. 5,7-DHT-lesions of the dorsal hippocampus did not alter the effects of phencyclidine on spatial d or entropy—despite potentiating total distance moved—but caused a slight reduction in levels of MK-801-induced entropy. Taken together, serotonergic lesions targeting the dorsal hippocampus unmask a functional differentiation of the hyperlocomotor effects of phencyclidine and MK 801. These findings have implications for studies utilising NMDA receptor antagonists in modeling glutamatergic dysfunction in schizophrenia.

  1. Lowest-order average effect of turbulence on atmospheric profiles derived from radio occultation

    International Nuclear Information System (INIS)

    Eshleman, V.R.; Haugstad, B.S.

    1977-01-01

    Turbulence in planetary atmospheres and ionospheres causes changes in angles of refraction of radio waves used in occultation experiments. Atmospheric temperature and pressure profiles, and ionospheric electron concentration profiles, derived from radio occultation measurements of Doppler frequency contain errors due to such angular offsets. The lowest-order average errors are derived from a geometrical-optics treatment of the radio-wave phase advance caused by the addition of uniform turbulence to an initially homogeneous medium. It is concluded that the average profile errors are small and that precise Doppler frequency measurements at two or more wavelengths could be used to help determine characteristics of the turbulence, as well as accuracy limits and possible correction terms for the profiles. However, a more detailed study of both frequency and intensity characteristics in radio and optical occultation measurements of turbulent planetary atmospheres and ionospheres is required to realize the full potential of such measurements

  2. An integration time adaptive control method for atmospheric composition detection of occultation

    Science.gov (United States)

    Ding, Lin; Hou, Shuai; Yu, Fei; Liu, Cheng; Li, Chao; Zhe, Lin

    2018-01-01

    When sun is used as the light source for atmospheric composition detection, it is necessary to image sun for accurate identification and stable tracking. In the course of 180 second of the occultation, the magnitude of sun light intensity through the atmosphere changes greatly. It is nearly 1100 times illumination change between the maximum atmospheric and the minimum atmospheric. And the process of light change is so severe that 2.9 times per second of light change can be reached. Therefore, it is difficult to control the integration time of sun image camera. In this paper, a novel adaptive integration time control method for occultation is presented. In this method, with the distribution of gray value in the image as the reference variable, and the concepts of speed integral PID control, the integration time adaptive control problem of high frequency imaging. The large dynamic range integration time automatic control in the occultation can be achieved.

  3. Magnetic field orientations in Saturn's upper ionosphere inferred from Voyager radio occultations

    Science.gov (United States)

    Hinson, D. P.

    1984-01-01

    The radio scintillations observed during occultations of Voyagers 1 and 2 by Saturn are analyzed to determine the morphology of plasma irregularities and hence the magnetic field orientation in Saturn's upper atmosphere. The measurement techniques, the weak scattering theory, and the method used to relate the observed radio scintillations to physical properties of the ionospheric irregularities are briefly described. Results on the spatial characteristics of the irregularities are presented, and the magnetic field orientation in Saturn's ionosphere is inferred. Although the occultation measurements generally confirm the accuracy of the Saturnian magnetic field model of Connerney et al. (1982), it is found that a small adjustment of the coefficients in that model's zonal harmonic expansion would remove the discrepancy between the model predictions and the measurements. A strategy for obtaining improved measurements of Saturn's magnetic field from radio occultation observations of scintillations and Faraday rotation using an orbiting spacecraft is briefly discussed.

  4. Helios-1 Faraday rotation experiment - Results and interpretations of the solar occultations in 1975

    Science.gov (United States)

    Volland, H.; Bird, M. K.; Levy, G. S.; Stelzried, C. T.; Seidel, B. L.

    1977-01-01

    The first of two solar occultations of the satellite Helios-1 in 1975 occurred in April when the satellite's ray path approached the west limb of the sun to a minimum distance of 1.63 solar radii. The second occultation took place in late August/early September when Helios-1 was totally eclipsed by the photosphere. Measurements of the polarization angle of the linearly polarized telemetry signal were performed with automatic tracking polarimeters at the 64 m Goldstone Tracking Station in California and also at the 100 m radio telescope in Effelsberg, West Germany. The coronal Faraday rotation as a function of the solar offset for both occultations is shown in graphs. The theoretical significance of the observations is investigated.

  5. Do X-ray-occult fractures play a role in chronic pain following a whiplash injury?

    DEFF Research Database (Denmark)

    Hertzum-Larsen, Rasmus; Petersen, Henrik; Kasch, Helge

    2014-01-01

    symptoms following an MVA was invited to have a cervical SPECT shortly post injury and again 6 months later. Associations between occult fractures and pain levels at baseline, 6 and 12 months of follow-up were analyzed. Eighty-eight patients had baseline SPECT performed at median 15 days (range 3-28) post......Whiplash trauma in motor vehicle accidents (MVA) may involve various painful soft tissue damages, but weeks/months later a minority of victims still suffers from various long-lasting and disabling symptoms, whiplash-associated disorders (WAD). The etiology is currently unknown, but X......-ray-occult fractures may be one cause in some cases. The purpose of this prospective study was to examine the association between occult fractures, as seen on bone single photon emission computed tomography (SPECT), with neck-, head- and arm pain. An inception cohort of 107 patients presenting with acute whiplash...

  6. Occult Pelvic Lymph Node Involvement in Bladder Cancer: Implications for Definitive Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Goldsmith, Benjamin; Baumann, Brian C.; He, Jiwei; Tucker, Kai; Bekelman, Justin; Deville, Curtiland; Vapiwala, Neha [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Vaughn, David; Keefe, Stephen M. [Department of Medical Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Guzzo, Thomas; Malkowicz, S. Bruce [Department of Urology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (United States); Christodouleas, John P., E-mail: christojo@uphs.upenn.edu [Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (United States)

    2014-03-01

    Purpose: To inform radiation treatment planning for clinically staged, node-negative bladder cancer patients by identifying clinical factors associated with the presence and location of occult pathologic pelvic lymph nodes. Methods and Materials: The records of patients with clinically staged T1-T4N0 urothelial carcinoma of the bladder undergoing radical cystectomy and pelvic lymphadenectomy at a single institution were reviewed. Logistic regression was used to evaluate associations between preoperative clinical variables and occult pathologic pelvic or common iliac lymph nodes. Percentages of patient with involved lymph node regions entirely encompassed within whole bladder (perivesicular nodal region), small pelvic (perivesicular, obturator, internal iliac, and external iliac nodal regions), and extended pelvic clinical target volume (CTV) (small pelvic CTV plus common iliac regions) were calculated. Results: Among 315 eligible patients, 81 (26%) were found to have involved pelvic lymph nodes at the time of surgery, with 38 (12%) having involved common iliac lymph nodes. Risk of occult pathologically involved lymph nodes did not vary with clinical T stage. On multivariate analysis, the presence of lymphovascular invasion (LVI) on preoperative biopsy was significantly associated with occult pelvic nodal involvement (odds ratio 3.740, 95% confidence interval 1.865-7.499, P<.001) and marginally associated with occult common iliac nodal involvement (odds ratio 2.307, 95% confidence interval 0.978-5.441, P=.056). The percentages of patients with involved lymph node regions entirely encompassed by whole bladder, small pelvic, and extended pelvic CTVs varied with clinical risk factors, ranging from 85.4%, 95.1%, and 100% in non-muscle-invasive patients to 44.7%, 71.1%, and 94.8% in patients with muscle-invasive disease and biopsy LVI. Conclusions: Occult pelvic lymph node rates are substantial for all clinical subgroups, especially patients with LVI on biopsy. Extended

  7. Detection of an occult transclival cerebrospinal fluid fistula by CT and MRI

    Energy Technology Data Exchange (ETDEWEB)

    Schick, B.; Brors, D.; Draf, W. [Department of Ear, Nose and Throat Diseases, Head, Neck and Facial Plastic Surgery, Marburg Univ. (Germany); Goedecke, A. [Department of Radiology, Academic Teaching Hospital, Fulda (Germany); Prescher, A. [Department of Anatomy and Embryology, University Medical School, RWTH, Aachen (Germany)

    1998-12-01

    We describe an unusual occult transclival cerebrospinal fluid (CSF) fistula to the sphenoid sinus demonstrated by MRI. CT was performed because of a posterior cerebral infarct caused by cardiac arrhythmia. Axial sections showed fluid in the sphenoid sinus. High-resolution scans revealed a bony defect 3 mm in diameter of the posterior wall of the sphenoid sinus, and MRI showed a transclival CSF fistula. This occult lesion was confirmed by surgery and duraplasty was successfully performed via an endonasal approach. (orig.) With 3 figs., 19 refs.

  8. Occult Invasive Lobular Carcinoma of Breast Detected by Stomach Metastasis: A Case Report

    International Nuclear Information System (INIS)

    KIm, So Jung; Jung, Hae Kyoung; Ko, Kyung Hee; Yoon, Jung Hyun

    2012-01-01

    Gastric metastasis from primary breast cancer is a rare phenomenon that is more prevalent in the invasive lobular type of breast cancer. We describe a very rare case of occult invasive lobular cancer of the breast detected by the initial presentation of gastric metastasis in a patient without a history of breast cancer. A 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) which showed increased FDG uptake in the stomach, abdominal mesentery and the right breast, and played pivotal roles in the detection of occult primary breast cancer and a diagnosis of gastric metastasis as an ancillary method for obtaining histological results and immunohistochemical stains.

  9. Occult injuries of the femoral neck in osteoporosis of aged patients

    International Nuclear Information System (INIS)

    Reichelt, H.G.

    1985-01-01

    Fractures of the femoral neck in elderly patients are often a complication in osteoporosis. Diagnosis of fractures with displacement and compression of fragments is quite easy. The negative radiograph in old patients complaining of hip pain is generally considered a characteristic feature of presensile osteoporotic pain. Clinical examples present patients with hip pain caused by occult injuries of the femoral neck. They should be regarded as imminent fractures and adequately treated. Bone scan is very helpful in the early detection of such occult osteroporotic injuries. (orig.) [de

  10. Occult Invasive Lobular Carcinoma of Breast Detected by Stomach Metastasis: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    KIm, So Jung; Jung, Hae Kyoung; Ko, Kyung Hee; Yoon, Jung Hyun [Dept. of Radiology, Bundang CHA general Hospital, CHA University College of Medicine, Seongnam (Korea, Republic of)

    2012-02-15

    Gastric metastasis from primary breast cancer is a rare phenomenon that is more prevalent in the invasive lobular type of breast cancer. We describe a very rare case of occult invasive lobular cancer of the breast detected by the initial presentation of gastric metastasis in a patient without a history of breast cancer. A 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) which showed increased FDG uptake in the stomach, abdominal mesentery and the right breast, and played pivotal roles in the detection of occult primary breast cancer and a diagnosis of gastric metastasis as an ancillary method for obtaining histological results and immunohistochemical stains.

  11. Naturally occurring mutations in large surface genes related to occult infection of hepatitis B virus genotype C.

    Directory of Open Access Journals (Sweden)

    Hong Kim

    Full Text Available Molecular mechanisms related to occult hepatitis B virus (HBV infection, particularly those based on genotype C infection, have rarely been determined thus far in the ongoing efforts to determine infection mechanisms. Therefore, we aim to elucidate the mutation patterns in the surface open reading frame (S ORF underlying occult infections of HBV genotype C in the present study. Nested PCRs were applied to 624 HBV surface antigen (HBsAg negative Korean subjects. Cloning and sequencing of the S ORF gene was applied to 41 occult cases and 40 control chronic carriers. Forty-one (6.6% of the 624 Korean adults with HBsAg-negative serostatus were found to be positive for DNA according to nested PCR tests. Mutation frequencies in the three regions labeled here as preS1, preS2, and S were significantly higher in the occult subjects compared to the carriers in all cases. A total of two types of deletions, preS1 deletions in the start codon and preS2 deletions as well as nine types of point mutations were significantly implicated in the occult infection cases. Mutations within the "a" determinant region in HBsAg were found more frequently in the occult subjects than in the carriers. Mutations leading to premature termination of S ORF were found in 16 occult subjects (39.0% but only in one subject from among the carriers (2.5%. In conclusion, our data suggest that preS deletions, the premature termination of S ORF, and "a" determinant mutations are associated with occult infections of HBV genotype C among a HBsAg-negative population. The novel mutation patterns related to occult infection introduced in the present study can help to broaden our understanding of HBV occult infections.

  12. Lack of Social Support Raises Stress Vulnerability in Rats with a History of Ancestral Stress.

    Science.gov (United States)

    Faraji, Jamshid; Soltanpour, Nabiollah; Lotfi, Hamid; Moeeini, Reza; Moharreri, Ali-Reza; Roudaki, Shabnam; Hosseini, S Abedin; Olson, David M; Abdollahi, Ali-Akbar; Soltanpour, Nasrin; Mohajerani, Majid H; Metz, Gerlinde A S

    2017-07-13

    Stress is a primary risk factor for psychiatric disorders. However, it is not fully understood why some stressed individuals are more vulnerable to psychiatric disorders than others. Here, we investigated whether multigenerational ancestral stress produces phenotypes that are sensitive to depression-like symptoms in rats. We also examined whether social isolation reveals potentially latent sensitivity to depression-like behaviours. F4 female rats born to a lineage of stressed mothers (F0-F3) received stress in adulthood while housed in pairs or alone. Social isolation during stress induced cognitive and psychomotor retardation only in rats exposed to ancestral stress. Social isolation also hampered the resilience of the hypothalamic-pituitary-adrenal axis to chronic stress and reduced hippocampal volume and brain-derived neurotrophic factor (BDNF) expression. Thus, synergy between social isolation and stress may unmask a latent history of ancestral stress, and raises vulnerability to mental health conditions. The findings support the notion that social support critically promotes stress coping and resilience.

  13. Titan's Surface Composition from Cassini VIMS Solar Occultation Observations

    Science.gov (United States)

    McCord, Thomas; Hayne, Paul; Sotin, Christophe

    2013-04-01

    Titan's surface is obscured by a thick absorbing and scattering atmosphere, allowing direct observation of the surface within only a few spectral win-dows in the near-infrared, complicating efforts to identify and map geologi-cally important materials using remote sensing IR spectroscopy. We there-fore investigate the atmosphere's infrared transmission with direct measure-ments using Titan's occultation of the Sun as well as Titan's reflectance measured at differing illumination and observation angles observed by Cas-sini's Visual and Infrared Mapping Spectrometer (VIMS). We use two im-portant spectral windows: the 2.7-2.8-mm "double window" and the broad 5-mm window. By estimating atmospheric attenuation within these windows, we seek an empirical correction factor that can be applied to VIMS meas-urements to estimate the true surface reflectance and map inferred composi-tional variations. Applying the empirical corrections, we correct the VIMS data for the viewing geometry-dependent atmospheric effects to derive the 5-µm reflectance and 2.8/2.7-µm reflectance ratio. We then compare the cor-rected reflectances to compounds proposed to exist on Titan's surface. We propose a simple correction to VIMS Titan data to account for atmospheric attenuation and diffuse scattering in the 5-mm and 2.7-2.8 mm windows, generally applicable for airmass water ice for the majority of the low-to-mid latitude area covered by VIMS measurements. Four compositional units are defined and mapped on Titan's surface based on the positions of data clusters in 5-mm vs. 2.8/2.7-mm scatter plots; a simple ternary mixture of H2O, hydrocarbons and CO2 might explain the reflectance properties of these surface units. The vast equatorial "dune seas" are compositionally very homogeneous, perhaps suggesting transport and mixing of particles over very large distances and/or and very consistent formation process and source material. The composi-tional branch characterizing Tui Regio and Hotei Regio is

  14. A variational regularization of Abel transform for GPS radio occultation

    Directory of Open Access Journals (Sweden)

    T.-K. Wee

    2018-04-01

    Full Text Available In the Global Positioning System (GPS radio occultation (RO technique, the inverse Abel transform of measured bending angle (Abel inversion, hereafter AI is the standard means of deriving the refractivity. While concise and straightforward to apply, the AI accumulates and propagates the measurement error downward. The measurement error propagation is detrimental to the refractivity in lower altitudes. In particular, it builds up negative refractivity bias in the tropical lower troposphere. An alternative to AI is the numerical inversion of the forward Abel transform, which does not incur the integration of error-possessing measurement and thus precludes the error propagation. The variational regularization (VR proposed in this study approximates the inversion of the forward Abel transform by an optimization problem in which the regularized solution describes the measurement as closely as possible within the measurement's considered accuracy. The optimization problem is then solved iteratively by means of the adjoint technique. VR is formulated with error covariance matrices, which permit a rigorous incorporation of prior information on measurement error characteristics and the solution's desired behavior into the regularization. VR holds the control variable in the measurement space to take advantage of the posterior height determination and to negate the measurement error due to the mismodeling of the refractional radius. The advantages of having the solution and the measurement in the same space are elaborated using a purposely corrupted synthetic sounding with a known true solution. The competency of VR relative to AI is validated with a large number of actual RO soundings. The comparison to nearby radiosonde observations shows that VR attains considerably smaller random and systematic errors compared to AI. A noteworthy finding is that in the heights and areas that the measurement bias is supposedly small, VR follows AI very closely in the

  15. A variational regularization of Abel transform for GPS radio occultation

    Science.gov (United States)

    Wee, Tae-Kwon

    2018-04-01

    In the Global Positioning System (GPS) radio occultation (RO) technique, the inverse Abel transform of measured bending angle (Abel inversion, hereafter AI) is the standard means of deriving the refractivity. While concise and straightforward to apply, the AI accumulates and propagates the measurement error downward. The measurement error propagation is detrimental to the refractivity in lower altitudes. In particular, it builds up negative refractivity bias in the tropical lower troposphere. An alternative to AI is the numerical inversion of the forward Abel transform, which does not incur the integration of error-possessing measurement and thus precludes the error propagation. The variational regularization (VR) proposed in this study approximates the inversion of the forward Abel transform by an optimization problem in which the regularized solution describes the measurement as closely as possible within the measurement's considered accuracy. The optimization problem is then solved iteratively by means of the adjoint technique. VR is formulated with error covariance matrices, which permit a rigorous incorporation of prior information on measurement error characteristics and the solution's desired behavior into the regularization. VR holds the control variable in the measurement space to take advantage of the posterior height determination and to negate the measurement error due to the mismodeling of the refractional radius. The advantages of having the solution and the measurement in the same space are elaborated using a purposely corrupted synthetic sounding with a known true solution. The competency of VR relative to AI is validated with a large number of actual RO soundings. The comparison to nearby radiosonde observations shows that VR attains considerably smaller random and systematic errors compared to AI. A noteworthy finding is that in the heights and areas that the measurement bias is supposedly small, VR follows AI very closely in the mean refractivity

  16. Molecular analysis of hepatitis B virus (HBV in an HIV co-infected patient with reactivation of occult HBV infection following discontinuation of lamivudine-including antiretroviral therapy

    Directory of Open Access Journals (Sweden)

    Costantini Andrea

    2011-11-01

    Full Text Available Abstract Background Occult hepatitis B virus (HBV infection (OBI is characterized by HBV DNA persistence even though the pattern of serological markers indicates an otherwise resolved HBV infection. Although OBI is usually clinically silent, immunocompromised patients may experience reactivation of the liver disease. Case presentation We report the case of an individual with human immunodeficiency virus (HIV infection and anti-HBV core antibody positivity, who experienced severe HBV reactivation after discontinuation of lamivudine-including antiretroviral therapy (ART. HBV sequencing analysis showed a hepatitis B surface antigen escape mutant whose presence in an earlier sample excluded reinfection. Molecular sequencing showed some differences between two isolates collected at a 9-year interval, indicating HBV evolution. Resumption of ART containing an emtricitabine/tenofovir combination allowed control of plasma HBV DNA, which fell to undetectable levels. Conclusion This case stresses the ability of HBV to evolve continuously, even during occult infection, and the effectiveness of ART in controlling OBI reactivation in HIV-infected individuals.

  17. Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome.

    Science.gov (United States)

    Helm, Benjamin M; Willer, Jason R; Sadeghpour, Azita; Golzio, Christelle; Crouch, Eric; Vergano, Samantha Schrier; Katsanis, Nicholas; Davis, Erica E

    2017-07-19

    combined with research-based genetic and functional studies, we have characterized a recurrent IFT140 mutation in the proband; together, these data are consistent with MZSDS. Additionally, we report a rare instance of a uniparental isodisomy unmasking a deleterious mutation to cause a ciliary disorder.

  18. Prospective, unmasked evaluation of the iStent® inject system for open-angle glaucoma: synergy trial.

    Science.gov (United States)

    Voskanyan, Lilit; García-Feijoó, Julián; Belda, Jose I; Fea, Antonio; Jünemann, Anselm; Baudouin, Christophe

    2014-02-01

    Micro-invasive glaucoma surgical implantation of trabecular micro-bypass stents, previously shown to be safe and effective for open-angle glaucoma (OAG) subjects during cataract surgery, was considered for evaluation as a sole procedure. The aim of this study was to evaluate the safety and intraocular pressure (IOP)-lowering efficacy after ab interno implantation of two Glaukos Trabecular Micro-Bypass iStent inject second generation devices in subjects with OAG. This study was performed at sites in France, Germany, Italy, Republic of Armenia, and Spain. In this pan-European, multi-center prospective, post-market, unmasked study, 99 patients with OAG on at least two topical ocular hypotensive medications who required additional IOP lowering to control glaucoma disease underwent implantation of two GTS400 stents in a stand-alone procedure. Patients were qualified if they presented with preoperative mean IOP between 22 and 38 mmHg after medication washout. Postoperatively, subjects were assessed at Day 1, Months 1, 3, 6, 7, 9, and 12. IOP, medication use and safety were assessed at each visit. Sixty-six percent of subjects achieved IOP ≤18 mmHg at 12 months without medication, and 81% of subjects achieved Month 12 IOP ≤ 18 mmHg with either a single medication or no medication. Mean baseline washout IOP values decreased by 10.2 mmHg or 39.7% from 26.3 (SD 3.5) mmHg to 15.7 (SD 3.7) mmHg at Month 12. Mean IOP at 12 months was 14.7 (SD 3.1) mmHg in subjects not using ocular hypotensive medications. Reduction from preoperative medication burden was achieved in 86.9% of patients, including 15.2% with reduction of one medication and 71.7% with reduction of two or more medications. Postoperative complications occurred at a low rate and resolved without persistent effects. In this series, implantation of two trabecular micro-bypass second generation stents in subjects with OAG resulted in IOP and medication reduction and favorable safety outcomes.

  19. Treatment for occult hepatocellular carcinoma: does it offer survival advantages over symptom-driven treatment?

    Science.gov (United States)

    Kim, Kwang Min; Kim, Jiyu; Sinn, Dong Hyun; Kim, Hye Seung; Kim, Kyunga; Kang, Wonseok; Gwak, Geum-Youn; Paik, Yong-Han; Choi, Moon Seok; Lee, Joon Hyeok; Koh, Kwang Cheol; Paik, Seung Woon

    2018-04-03

    In order to claim a benefit of screen-based diagnosis for asymptomatic individuals, treatment of occult disease needs to offer survival advantages compared to the treatment of symptomatic disease, yet information on this issue is scarce with regard to hepatocellular carcinoma (HCC) screening. A total of 3353 treatment-naïve, consecutive, newly diagnosed HCC patients [age: 57.9 ± 10.3, male: 2,689 (80.2%), hepatitis B virus: 2555 (76.2%)], diagnosed between 2010 and 2013 were analyzed. Data on the mode of detection was prospectively collected at the time of HCC diagnosis and was used to group patients into occult or symptomatic cases. Overall, 643 (19.2%) patients were symptomatic cases. The proportion of patients undergoing resection, radiofrequency ablation or transplantation were lower in symptomatic cases than occult cases (20.8 vs. 56.2%, p offered a survival benefit to patients over symptomatic cases. These data support screening practices for asymptomatic individuals to diagnose occult HCC.

  20. Endoscopic Follow-Up of Positive Fecal Occult Blood Testing in the Ontario FOBT Project

    Directory of Open Access Journals (Sweden)

    Lawrence Paszat

    2007-01-01

    Full Text Available BACKGROUND: The Ontario FOBT Project is a pilot study of fecal occult blood testing (FOBT for colorectal cancer screening conducted among age-eligible volunteers (50 to 75 years in 12 of 37 public health regions in Ontario.

  1. First Ionospheric Results From the MAVEN Radio Occultation Science Experiment (ROSE)

    Science.gov (United States)

    Withers, Paul; Felici, M.; Mendillo, M.; Moore, L.; Narvaez, C.; Vogt, M. F.; Jakosky, B. M.

    2018-05-01

    Radio occultation observations of the ionosphere of Mars can span the full vertical extent of the ionosphere, in contrast to in situ measurements that rarely sample the main region of the ionosphere. However, most existing radio occultation electron density profiles from Mars were acquired without clear context for the solar forcing or magnetospheric conditions, which presents challenges for the interpretation of these profiles. Here we present 48 ionospheric electron density profiles acquired by the Mars Atmosphere and Volatile EvolutioN mission (MAVEN) Radio Occultation Science Experiment (ROSE) from 5 July 2016 to 27 June 2017 at solar zenith angles of 54° to 101°. Latitude coverage is excellent, and comprehensive context for the interpretation of these profiles is provided by other MAVEN instruments. The profiles show a 9-km increase in ionospheric peak altitude in January 2017 that is associated with a lower atmospheric dust storm, variations in electron densities in the M1 layer that cannot be explained by variations in the solar soft X-ray flux, and topside electron densities that are larger in strongly magnetized regions than in weakly magnetized regions. MAVEN Radio Occultation Science Experiment electron density profiles are publicly available on the NASA Planetary Data System.

  2. Occult hepatitis B virus among the patients with abnormal alanine transaminase.

    Science.gov (United States)

    Makvandi, Manoochehr; Neisi, Niloofar; Khalafkhany, Davod; Makvandi, Kamyar; Hajiani, Eskandar; Shayesteh, Ali Akbar; Masjedi Zadeh, Abdolrahim; Sina, Amir Hosein; Hamidifard, Mojtaba; Rasti, Mojtaba; Aryan, Ehsan; Ahmadi, Kambiz; Yad Yad, Mohammad Jafar

    2014-08-01

    The occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the sera or in the liver biopsy and the absence of hepatitis B surface antigen (HBsAg) by serological test. The current study aimed to evaluate the occult HBV infection by polymerase chain reaction (PCR) and determine HBV genotyping among the patients with abnormal alanine transaminase (ALT) in Ahvaz city, Iran. The sera of 120 patients, 54 (45%) females and 66 (55%) males, with abnormal ALT 40-152 IU were collected. All the patients were negative for HBsAg for more than one year. The patients` sera were tested by PCR using primers specified for the S region of HBV. Then the positive PCR products were sequenced to determine HBV genotyping and phylogenic tree. Of these 120 subjects, 12 (10%) patients including 6 (5%) males and 6 (5%) females were found positive for HBV DNA by PCR, which indicated the presence of occult HBV infection among these patients. The sequencing results revealed that genotype D was predominant with sub-genotyping D1 among OBI patients. Occult hepatitis B infection is remarkably prevalent in Ahvaz, Iran, and should be considered as a potential risk factor for the transmission of Hepatitis B Virus throughout the community by the carriers.

  3. Lunar occultation of the Galactic center at 2.2 microns

    NARCIS (Netherlands)

    Adams, D. J.; Becklin, E. E.; Jameson, R. F.; Longmore, A. J.; Sandqvist, Aa.; Valentijn, E.

    1988-01-01

    Results of the lunar occultation of IRS 16 on 1986 September 11 are reported. Sixty percent of the observed flux in a 6arcsec.5 beam comes from four discrete sources. Three sources are unresolved pointlike objects (<0arcsec.05) and are assumed to be individual stars. The fourth object is well

  4. Occult Hepatitis B Virus Among the Patients With Abnormal Alanine Transaminase

    Science.gov (United States)

    Makvandi, Manoochehr; Neisi, Niloofar; Khalafkhany, Davod; Makvandi, Kamyar; Hajiani, Eskandar; Shayesteh, Ali Akbar; Masjedi Zadeh, Abdolrahim; Sina, Amir Hosein; Hamidifard, Mojtaba; Rasti, Mojtaba; Aryan, Ehsan; Ahmadi, Kambiz; Yad Yad, Mohammad Jafar

    2014-01-01

    Background: The occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the sera or in the liver biopsy and the absence of hepatitis B surface antigen (HBsAg) by serological test. Objectives: The current study aimed to evaluate the occult HBV infection by polymerase chain reaction (PCR) and determine HBV genotyping among the patients with abnormal alanine transaminase (ALT) in Ahvaz city, Iran. Patients and Methods: The sera of 120 patients, 54 (45%) females and 66 (55%) males, with abnormal ALT 40-152 IU were collected. All the patients were negative for HBsAg for more than one year. The patients` sera were tested by PCR using primers specified for the S region of HBV. Then the positive PCR products were sequenced to determine HBV genotyping and phylogenic tree. Results: Of these 120 subjects, 12 (10%) patients including 6 (5%) males and 6 (5%) females were found positive for HBV DNA by PCR, which indicated the presence of occult HBV infection among these patients. The sequencing results revealed that genotype D was predominant with sub-genotyping D1 among OBI patients. Conclusions: Occult hepatitis B infection is remarkably prevalent in Ahvaz, Iran, and should be considered as a potential risk factor for the transmission of Hepatitis B Virus throughout the community by the carriers. PMID:25485052

  5. Post traumatic urinary extravasation in occult urinary obstruction: Report of three cases

    Directory of Open Access Journals (Sweden)

    Jyoti Bothra

    2016-01-01

    Full Text Available Urinary extravastion after blunt abdominal trauma is seen often and generally treated conservatively. However a blunt renal trauma causing huge amount of extravasations and symptoms disproportionate to the severity of trauma should alarm the surgeon towards an underlying occult renal pathology usually an obstruction. In this case series, we share three such experiences and their management.

  6. Detection of occult hepatitis B virus among chronic hepatitis C patients

    African Journals Online (AJOL)

    Background: Concurrent infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) are increasingly recognized in patients with chronic hepatitis. In Egypt, the last decade showed a remarkable decline in HBV infection associated with remarkable rise in HCV infection. The probable impact of occult HBV in patients ...

  7. Earlier stages of colorectal cancer detected with immunochemical faecal occult blood tests

    NARCIS (Netherlands)

    van Rossum, L. G. M.; van Rijn, A. F.; van Munster, I. P.; Jansen, J. B. M. J.; Fockens, P.; Laheij, R. J. F.; Dekker, E.

    2009-01-01

    Background: The aim of colorectal cancer screening is to improve prognosis by the detection of early cancer and precursor stages. We compared the stage distribution of asymptomatic colorectal cancer patients detected by a positive immunochemical or guaiac-based faecal occult blood test (FOBT) with

  8. Aplastic crisis in occult hereditary spherocytosis caused by human parvovirus (HPV B19).

    Science.gov (United States)

    Rappaport, E S; Quick, G; Ransom, D; Helbert, B; Frankel, L S

    1989-02-01

    We have reported a case of aplastic crisis occurring in an 11-year-old black boy with occult hereditary spherocytosis. An etiologic diagnosis of human parvovirus (HPV) B19 infection was confirmed serologically. The Coulter Model S + IV proved useful for both diagnosis and treatment monitoring through serial histograms. The relationship of HPV infection and aplastic crisis is discussed.

  9. Clinical relevance of occult tumor cells in lymph nodes from gastric cancer patients.

    NARCIS (Netherlands)

    Doekhie, F.S.; Mesker, W.H.; Krieken, J.H.J.M. van; Kok, N.F.; Hartgrink, H.H.; Kranenbarg, E.K.; Putter, H.; Kuppen, P.J.; Tanke, H.J.; Tollenaar, R.A.E.M.; Velde, C.J. van de

    2005-01-01

    The current method for staging in gastric cancer is not sufficient as even after a complete primary tumor resection, patients with node-negative gastric cancer suffer from disease recurrence. In this study, the relation between disease recurrence and the presence of occult tumor cells (OTC) in lymph

  10. Design and Verification of External Occulters for Direct Imaging of Extrasolar Planets

    Science.gov (United States)

    Cady, Eric

    2011-01-01

    An occulter is an optical element which is placed in front of the telescope to block most of the light from a star before it reaches the optics inside, without blocking the planet.In our case, we use two spacecraft ying in formation: First has its edge shaped to cancel the starlight Second is the telescope which images the star and planet

  11. Inappropriate use of the faecal occult blood test in a university hospital in the Netherlands

    NARCIS (Netherlands)

    van Rijn, Anne F.; Stroobants, An K.; Deutekom, Marije; Lauppe, Corinne; Sturk, Auguste; Bossuyt, Patrick M. M.; Fockens, Paul; Dekker, Evelien

    2012-01-01

    Objectives Although all international guidelines state that there is no indication to perform a faecal occult blood test (FOBT) in symptomatic patients, we believe the test is frequently used as a diagnostic test. The objective of this study was to investigate whether the current guidelines for FOBT

  12. Tropical cyclone cloud‐top height and vertical temperature structure detection using GPS radio occultation measurements

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Ho, Shu‐Peng; Randel, William

    2013-01-01

    The accurate determination of tropical cyclone (TC) cloud-top height and its vertical thermal structure using the GPS radio occultation (RO) technique is demonstrated in this study. Cloud-top heights are determined by using the bending angle anomaly and the temperature anomaly profiles during...

  13. Indeling occulte tumorcellen in de lymfklieren bij patiënten met darmkanker onvoldoende betrouwbaar

    NARCIS (Netherlands)

    van der Zaag, E. S.; Welling, L.; Peters, H. M.; van de Vijver, M. J.; Bemelman, W. A.; Buskens, C. J.

    2011-01-01

    OBJECTIVE: To assess interobserver agreement between pathologists in judging photographs of lymph node preparations of occult tumour cells of patients with colon cancer. DESIGN: Descriptive and comparative study of interobserver variability. METHODS: All lymph nodes of 82 pN0 patients with colon

  14. GPS radio occultation technique for measurement of the atmosphere above tropical cyclones

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Neubert, Torsten; Syndergaard, Stig

    2009-01-01

    Water vapour transport to the upper troposphere (UT) and lower stratosphere (LS) by deep convective storms affects the radiation balance of the atmosphere and has been proposed as an important component of climate change. The aim of the work presented here is to understand if the GPS Radio Occult...... 2008 and reached a maximum intensity of Category 3....

  15. Estimation and evaluation of COSMIC radio occultation excess phase using undifferenced measurements

    Science.gov (United States)

    Xia, Pengfei; Ye, Shirong; Jiang, Kecai; Chen, Dezhong

    2017-05-01

    In the GPS radio occultation technique, the atmospheric excess phase (AEP) can be used to derive the refractivity, which is an important quantity in numerical weather prediction. The AEP is conventionally estimated based on GPS double-difference or single-difference techniques. These two techniques, however, rely on the reference data in the data processing, increasing the complexity of computation. In this study, an undifferenced (ND) processing strategy is proposed to estimate the AEP. To begin with, we use PANDA (Positioning and Navigation Data Analyst) software to perform the precise orbit determination (POD) for the purpose of acquiring the position and velocity of the mass centre of the COSMIC (The Constellation Observing System for Meteorology, Ionosphere and Climate) satellites and the corresponding receiver clock offset. The bending angles, refractivity and dry temperature profiles are derived from the estimated AEP using Radio Occultation Processing Package (ROPP) software. The ND method is validated by the COSMIC products in typical rising and setting occultation events. Results indicate that rms (root mean square) errors of relative refractivity differences between undifferenced and atmospheric profiles (atmPrf) provided by UCAR/CDAAC (University Corporation for Atmospheric Research/COSMIC Data Analysis and Archive Centre) are better than 4 and 3 % in rising and setting occultation events respectively. In addition, we also compare the relative refractivity bias between ND-derived methods and atmPrf profiles of globally distributed 200 COSMIC occultation events on 12 December 2013. The statistical results indicate that the average rms relative refractivity deviation between ND-derived and COSMIC profiles is better than 2 % in the rising occultation event and better than 1.7 % in the setting occultation event. Moreover, the observed COSMIC refractivity profiles from ND processing strategy are further validated using European Centre for Medium

  16. Sizes of the Smallest Particles at Saturn Ring Edges from Diffraction in UVIS Stellar Occultations

    Science.gov (United States)

    Eckert, S.; Colwell, J. E.; Becker, T. M.; Esposito, L. W.

    2017-12-01

    Cassini's Ultraviolet Imaging Spectrograph (UVIS) has observed more than 150 ring stellar occultations since its arrival at Saturn in 2004. We use stellar occultation data from the UVIS High Speed Photometer (HSP) to identify diffraction signals at ring edges caused by small particles diffracting light into the detector and consequently increasing the signal above that of the unocculted star. The shape of a diffraction signal is indicative of the particle size distribution at the ring edge, which may be a dynamically perturbed region. Becker et al. (2015 Icarus doi:10.1016/j.icarus.2015.11.001) analyzed diffraction signals at the outer edge of the A Ring and the edges of the Encke Gap. We apply the Becker et al. (2015) model to the outer edge of the B Ring as well as the edges of ringlets within the C Ring and Cassini Division. In addition, we analyze diffraction signatures at the A Ring outer edge in 2 new occultations. The best-fit model signals to these occultations are consistent with the findings of Becker et al. (2015) who found an average minimum particle size amin =4.5 mm and average power law slope q=3.2. At the B Ring outer edge, we detect a diffraction signal in 10 of 28 occultations in which the diffraction signal would be observable according to our criteria for star brightness and observation geometry. We find a mean amin =11 mm and a mean q=3.0. At both edges of the so-called "Strange" ringlet (R6) we find a mean amin = 20 mm and mean q values of 3.0 and 2.8 at the inner and outer edges, respectively. In contrast, we do not observe any clear diffraction signals at either edge of the wider Huygens ringlet. This could imply an absence of cm-scale or smaller particles and indicates that collisions here may be less vigorous than at the other ring edges analyzed in this study. We detect diffraction in a small fraction ( 10%) of occultations at 3 ringlets within the Cassini Division: the Herschel ringlet, the Laplace ringlet, and the Barnard ringlet. We

  17. Partially Transparent Petaled Mask/Occulter for Visible-Range Spectrum

    Science.gov (United States)

    Shiri, Ron Shahram; Wasylkiwskyj, Wasyl

    2013-01-01

    The presence of the Poisson Spot, also known as the spot of Arago, has been known since the 18th century. This spot is the consequence of constructive interference of light diffracted by the edge of the obstacle where the central position can be determined by symmetry of the object. More recently, many NASA missions require the suppression of this spot in the visible range. For instance, the exoplanetary missions involving space telescopes require telescopes to image the planetary bodies orbiting central stars. For this purpose, the starlight needs to be suppressed by several orders of magnitude in order to image the reflected light from the orbiting planet. For the Earth-like planets, this suppression needs to be at least ten orders of magnitude. One of the common methods of suppression involves sharp binary petaled occulters envisioned to be placed many thousands of miles away from the telescope blocking the starlight. The suppression of the Poisson Spot by binary sharp petal tips can be problematic when the thickness of the tips becomes smaller than the wavelength of the incident beam. First they are difficult to manufacture and also it invalidates the laws of physical optics. The proposed partially transparent petaled masks/occulters compensate for this sharpness with transparency along the surface of the petals. Depending on the geometry of the problem, this transparency can be customized such that only a small region of the petal is transparent and the remaining of the surface is opaque. This feature allows easy fabrication of this type of occultation device either as a mask or occulter. A partially transparent petaled mask/ occulter has been designed for the visible spectrum range. The mask/occulter can suppress the intensity along the optical axis up to ten orders of magnitude. The design process can tailor the mask shape, number of petals, and transparency level to the near-field and farfield diffraction region. The mask/occulter can be used in space

  18. Histopathological Parameters predicting Occult Nodal Metastases in Tongue Carcinoma Cases: An Indian Perspective.

    Science.gov (United States)

    Jacob, Tina Elizabeth; Malathi, N; Rajan, Sharada T; Augustine, Dominic; Manish, N; Patil, Shankargouda

    2016-01-01

    It is a well-established fact that in squamous cell carcinoma cases, the presence of lymph node metastases decreased the 5-year survival rate by 50% and also caused the recurrence of the primary tumor with development of distant metastases. Till date, the predictive factors for occult cervical lymph nodes metastases in cases of tongue squamous cell carcinoma remain inconclusive. Therefore, it is imperative to identify patients who are at the greatest risk for occult cervical metastases. This study was thus performed with the aim to identify various histopathologic parameters of the primary tumor that predict occult nodal metastases. The clinicopathologic features of 56 cases of lateral tongue squamous cell carcinoma with cT1NoMo/cT2NoMo as the stage and without prior radiotherapy or chemotherapy were considered. The surgical excision of primary tumor was followed by elective neck dissection. The glossectomy specimen along with the neck nodes were fixed in formalin and 5 urn thick sections were obtained. The hematoxylin & eosin stained sections were then subjected to microscopic examination. The primary tumor characteristics that were analyzed include tumor grade, invading front, depth of tumor, lymphovascular invasion, perineural invasion and inflammatory response. The nodes were examined for possible metastases using hematoxylin & eosin followed by cytokeratin immunohistochemistry. A total of 12 cases were found with positive occult nodal metastases. On performing univariate analysis, the histopathologic parameters that were found to be statistically significant were lymphovascular invasion (p = 0.004) and perineural invasion (p = 0.003) along with a cut-off depth of infiltration more than 5 mm (p = 0.01). Histopathologic assessment of the primary tumor specimen therefore continues to provide information that is central to guide clinical management, particularly in cases of occult nodal metastases. Clinical significance The study highlights the importance of

  19. Occult pneumothorax in trauma patients: should this be sought in the focused assessment with sonography for trauma examination?

    Science.gov (United States)

    Tam, Michael M K

    2005-01-01

    At present, CT scan is the gold standard for detecting occult traumatic pneumothorax not apparent on supine chest X-ray radiograph. Recently there were suggestions to expand focused assessment with sonography for trauma (FAST) to include thoracic ultrasound for detecting pneumothorax. The aim of the present study is to determine the incidence of occult pneumothorax (as shown by CT) in the subgroup of trauma patients undergoing FAST. Review of all trauma patients with FAST done from 1 June 2001 to 31 October 2002. Incidence of occult pneumothorax as diagnosed by CT was determined. Patients were not counted as having true occult pneumothorax if they had chest drains inserted before arrival or imaging studies. Selected clinical findings were tested for association with occult pneumothorax. In total, 143 patients underwent FAST, of whom 137 (95.8%) had chest X-ray examination performed. Of the 137 patients 59 required CT abdomen and/or thorax. Occult pneumothorax was found in three patients (2.1%). A history of thorax and/or abdominal injury plus one or more of: (i) mechanisms potentially causing major trauma; (ii) abnormal chest examination; and (iii) chest X-ray radiograph abnormality in the absence of pneumothorax, was significantly associated with the presence of occult pneumothorax (P = 0.03, Fisher's exact test; sensitivity: 100%; specificity: 71%; likelihood ratio: 3.42). The incidence of occult pneumothorax in the subgroup of trauma patients undergoing FAST is low. It implies that routine screening for its presence by adding thoracic ultrasound to FAST is unnecessary. Identifying those at risk of occult pneumothorax for further investigation appeared feasible.

  20. Stellar Occultations by TNOs and Centaurs: first results in the “Gaia era”

    Science.gov (United States)

    Rossi, Gustavo; Vieira-Martins, Roberto; Sicardy, Bruno; Ortiz, Jose Luis; Rio Group, Lucky Star Occultation Team, Granada Occultation Team

    2017-10-01

    After the first release of the GAIA catalog (in September/2016), stellar positions are now known with unprecedented accuracy, reaching values of the order of milliarcseconds. This improvement reflected into a stunning accuracy on the astrometry of moving objects, such as TNOs. Unfortunately, Gaia stars proper motions will be only available on the second data release (DR2) next year, so there is still a need to use hybrid stellar catalogs for occultation predictions until then. Despite that, stellar occultations predictions are now much more accurate, and the biggest uncertainties comes mainly from the object ephemerides. This issue will be overcome by large surveys such as the LSST, which will provide positions for the known TNOs and it is expected to increase the number of known TNOs by nearly 40,000, with an unprecedent amount of acquired information.This huge amount of data also poses a new era in stellar occultations: predictions will be very accurate and the participation of professional astronomers, laboratories, and the amateur community will be crucial to observe the predicted events; observation campaigns will need to be selected according to a specific scientific purpose such as the probability to detect rings or archs around a body, the presence of atmosphere or even the detection of topographic features; the development of softwares capable of reducing the data more efficiently and an easier method to coordinate observation campaigns are needed.Here we present some impressive results obtained from predictions and observed occultations in 2017 (among them we have Pluto, Chariklo and Haumea), the problems we are starting to face in the beginning of the “Gaia era” and the future challenges of stellar occultation.

  1. Theoretical performance of serrated external occulters for solar coronagraphy. Application to ASPIICS

    Science.gov (United States)

    Rougeot, R.; Aime, C.

    2018-04-01

    Context. This study is made in the context of the future solar coronagraph ASPIICS of the ESA formation-flying mission Proba-3. Aims: In the context of solar coronagraphy, we provide a comparative study of the theoretical performance of serrated (or toothed) external occulters by varying the number and size of the teeth, which we compare to the sharp-edged and apodized disks. The tooth height is small (a few centimeters), to avoid hindering the observation of the solar corona near the limb. We first analyze the diffraction pattern produced by such occulters. In a second step, we compute the umbra profile by integration over the Sun. Methods: We explored a few methods to compute the diffraction pattern. Two of them were implemented. The first is based on 2D fast Fourier transformation (FFT) routines and a multiplication by the Fresnel filter of the form exp(-iπλzu2). Simple rules were derived and discussed to set the sampling conditions. The Maggi-Rubinowicz representation is then proposed as an alternative method, and is proven to be very efficient for this study. Results: Serrated occulters tend to create a two-level intensity pattern, the inner being the darker, which perfectly matches a previously reported geometrical prediction. The diffraction in this central region is lower by two to four orders of magnitude when compared to the sharp-edged disk. The achieved umbra level at the center ranges from 10-4 to below 10-7, depending on the geometry of the teeth. Conclusions: Our study shows that serrated occulters can achieve a high rejection and can almost reach the performance of the apodized disk when very many teeth are used. We prove that shaped occulters must be preferred to simple disks in solar and stellar coronagraphy.

  2. Predictive factors of occult neck metastasis in patients with oral squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Renato Fortes Bittar

    Full Text Available ABSTRACT INTRODUCTION: It is well established that cervical lymph node metastasis is the most important prognostic factor in patients with oral squamous cell carcinoma of the upper aerodigestive tract. The definition of parameters and classifications that could separate patients in groups of low, intermediate and high-risk is being attempted for several years. OBJECTIVE: The objective of this study was to determine possible predictive factors related to the occurrence of occult cervical lymph node metastasis through the analysis of histopathological reports of surgical specimens obtained after oral squamous cell carcinoma resection and selective neck dissections of patients initially classified as N0. METHODS: This was a primary, retrospective, observational, case-control study. Histopathological reports were reviewed to determine if some findings were related to the occurrence of occult lymph node metastasis. The events analyzed were oral cavity subsites, pT-stage, muscular infiltration, desmoplasia, vascular emboli, perineural infiltration, tumor thickness and compromised margins. RESULTS: Occult cervical metastasis accounted for 19.10 percent of the cases. Desmoplasia, perineural infiltration, tumor thickness and pT4a stage are predictive factors of occult neck metastasis (p-value = 0.0488, 0.0326, 0.0395, 0.0488, respectively. CONCLUSION: The accurate definition of predictive factors of occult cervical metastasis may guide the selection of patients that should be referred to radiotherapy, avoiding the unnecessary exposure of low-risk patients to radiation and allowing a better regional control of the disease in those of moderate or high risk.

  3. Role of MRI in hip fractures, including stress fractures, occult fractures, avulsion fractures

    International Nuclear Information System (INIS)

    Nachtrab, O.; Cassar-Pullicino, V.N.; Lalam, R.; Tins, B.; Tyrrell, P.N.M.; Singh, J.

    2012-01-01

    MR imaging plays a vital role in the diagnosis and management of hip fractures in all age groups, in a large spectrum of patient groups spanning the elderly and sporting population. It allows a confident exclusion of fracture, differentiation of bony from soft tissue injury and an early confident detection of fractures. There is a spectrum of MR findings which in part is dictated by the type and cause of the fracture which the radiologist needs to be familiar with. Judicious but prompt utilisation of MR in patients with suspected hip fractures has a positive therapeutic impact with healthcare cost benefits as well as social care benefits.

  4. Fecal occult blood test for colorectal cancer screening: an evidence-based analysis.

    Science.gov (United States)

    2009-01-01

    Evaluation; RCT, randomized controlled trial.*Unlikely to be an important uncertainty.ES Table 2:GRADE Quality of Evidence for Diagnostic Tests: Implications of Testing Focusing on AccuracyNew Test and Reference TestPutative BenefitDiagnostic AccuracyPatient Outcomes and Expected Impact on ManagementSensitivitySpecificityTrue PositiveTrue NegativeFalse PositiveFalse NegativePresumed Influence on Outcomes Important to PatientsiFOBT and ColonoscopySimple, non-invasiveLessLessBenefit from diagnosis and treatment after confirmatory colonoscopySmall risk of bowel perforation during colonoscopyBenefit of reassuranceAnxiety/worry leading up to confirmatory colonoscopySmall risk of bowel perforation during confirmatory colonoscopyDetriment from delayed diagnosisDirectness of Evidence (Test Results) for Outcomes Important to PatientsSome uncertainty (until after confirmatory colonoscopy)No UncertaintyUncertaintyUncertaintyFOBT indicates fecal occult blood test; GRADE, Grading of Recommendations Assessment, Development and Evaluation.Es Table 3:Immunochemical FOBT - GRADE Quality of Evidence for Diagnostic StudiesNo. ofStudiesDesignLimitationsIndirectnessInconsistencyImprecise dataQuality6Diagnostic cohort (single test)(reference standard for positive and negative iFOBT results was colonoscopy)No serious limitationsTP Some uncertaintyTN No uncertaintyFP UncertaintyFN UncertaintyTP rate = 69%TN rate = 94%FP rate = 6%FN rate = 30%(from direct comparison study)Diagnostic cohort iFOBT sensitivities: 50% to 90%High I(2)in pooled sensitivity and specificityWide range in confidence intervals in direct comparison studyLow*FN indicates false negative; FOBT, fecal occult blood test; FP, false positive; Development and Evaluation; TN, true negative; TP, true positive.*Uncertainty until after confirmatory colonoscopy†Stress/worry for patient until confirmatory colonoscopy‡Detrimental effects due to delayed diagnosis.§For these 3 reasons, downgrade quality from High to Moderate.║For these 3

  5. Characteristics of atmospheric gravity waves observed using the MU (Middle and Upper atmosphere) radar and GPS (Global Positioning System) radio occultation.

    Science.gov (United States)

    Tsuda, Toshitaka

    2014-01-01

    The wind velocity and temperature profiles observed in the middle atmosphere (altitude: 10-100 km) show perturbations resulting from superposition of various atmospheric waves, including atmospheric gravity waves. Atmospheric gravity waves are known to play an important role in determining the general circulation in the middle atmosphere by dynamical stresses caused by gravity wave breaking. In this paper, we summarize the characteristics of atmospheric gravity waves observed using the middle and upper atmosphere (MU) radar in Japan, as well as novel satellite data obtained from global positioning system radio occultation (GPS RO) measurements. In particular, we focus on the behavior of gravity waves in the mesosphere (50-90 km), where considerable gravity wave attenuation occurs. We also report on the global distribution of gravity wave activity in the stratosphere (10-50 km), highlighting various excitation mechanisms such as orographic effects, convection in the tropics, meteorological disturbances, the subtropical jet and the polar night jet.

  6. Ms. Mentor Unmasked

    Science.gov (United States)

    Krebs, Paula

    2008-01-01

    This article presents an interview with Emily Toth, who writes the monthly "Ms. Mentor" academic advice column in the "Chronicle of Higher Education" and teaches in the English department at Louisiana State University, in Baton Rouge. She is the author of "Ms. Mentor's Impeccable Advice for Women in Academia" (1997), "Inside Peyton Place: The Life…

  7. Electromagnetic radiation unmasked

    International Nuclear Information System (INIS)

    Hart, P.

    1996-01-01

    This article describes the nature of the electromagnetic waves, what they are and how do they affect us. Current concern is focused on exposure to low level power-frequency magnetic fields like microwave radiation from mobile phones and leaking microwave ovens; high power radiation from defence and airport radars; fields close to high voltage transmission lines; radio frequency fields from industrial welders and heaters and DC magnetic fields in aluminium smelters. These fields with frequency less than 300 GHz do not carry sufficient energy to break chemical bonds and it is assumed that they cannot damage cell DNA. The amount of radiation absorbed by a human exposed to far field electromagnetic radiation (EMR) depends on the orientation and size of the person. In the 30-300 MHz range it is possible to excite resonance in the whole or partial body such as the head. It is emphasised that since there are some evidence that electromagnetic fields do harm, a policy of prudent avoidance is recommended, especially for children. ills

  8. Unmasking the Terror.

    Science.gov (United States)

    Chambers, Jamie C.

    2000-01-01

    Author recounts his personal experiences growing up as a youth of color and subsequent work as a youth counselor. Argues that all young people choose purposive behavior based on competing inborn motivational systems. Fear in any degree is an innate protective mechanism, but racism is an irrational fear. Provides strategies for confronting…

  9. Unmasking diogenes syndrome

    Directory of Open Access Journals (Sweden)

    Kashinath Nayak

    2015-01-01

    Full Text Available Diogenes syndrome is characterized by extreme self-neglect, social withdrawal, and poor personal and domestic hygiene. We report a case of Diogenes syndrome presenting with dermatitis passivata. An unusual "mask" of dirt resembling a carapace, onset of neglect after awareness of a breast lump and resumption of personal grooming and social activities after removal of the lump and counseling were seen.

  10. Prediction of occult hepatitis B virus infection in liver transplant donors through hepatitis B virus blood markers.

    Science.gov (United States)

    Tandoi, Francesco; Caviglia, Gian Paolo; Pittaluga, Fabrizia; Abate, Maria Lorena; Smedile, Antonina; Romagnoli, Renato; Salizzoni, Mauro

    2014-11-01

    Occult hepatitis B virus infection is defined as detectable HBV-DNA in liver of HBsAg-negative individuals, with or without detectable serum HBV-DNA. In deceased liver donors, results of tissue analysis cannot be obtained prior to allocation for liver transplantation. we investigated prevalence and predictability of occult hepatitis B using blood markers of viral exposure/infection in deceased liver donors. In 50 consecutive HBsAg-negative/anti-HBc-positive and 20 age-matched HBsAg-negative/anti-HBc-negative donors, a nested-PCR assay was employed in liver biopsies for diagnosis of occult hepatitis B according to Taormina criteria. All donors were characterized for plasma HBV-DNA and serum anti-HBs/anti-HBe. In liver tissue, occult hepatitis B was present in 30/50 anti-HBc-positive (60%) and in 0/20 anti-HBc-negative donors (pdonors with detectable HBV-DNA in plasma (n=5) or anti-HBs>1,000 mIU/mL (n=5) eventually showed occult infection, i.e, 10/30 occult hepatitis B-positive donors which could have been identified prior to transplantation. In the remaining 40 anti-HBc-positive donors, probability of occult infection was 62% for anti-HBe-positive and/or anti-HBs ≥ 58 mIU/mL; 29% for anti-HBe-negative and anti-HBsdonors, combining anti-HBc with other blood markers of hepatitis B exposure/infection allows to predict occult hepatitis B with certainty and speed in one third of cases. These findings might help refine the allocation of livers from anti-HBc-positive donors. Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  11. Amplification and protein overexpression of cyclin D1: Predictor of occult nodal metastasis in early oral cancer.

    Science.gov (United States)

    Noorlag, Rob; Boeve, Koos; Witjes, Max J H; Koole, Ronald; Peeters, Ton L M; Schuuring, Ed; Willems, Stefan M; van Es, Robert J J

    2017-02-01

    Accurate nodal staging is pivotal for treatment planning in early (stage I-II) oral cancer. Unfortunately, current imaging modalities lack sensitivity to detect occult nodal metastases. Chromosomal region 11q13, including genes CCND1, Fas-associated death domain (FADD), and CTTN, is often amplified in oral cancer with nodal metastases. However, evidence in predicting occult nodal metastases is limited. In 158 patients with early tongue and floor of mouth (FOM) squamous cell carcinomas, both CCND1 amplification and cyclin D1, FADD, and cortactin protein expression were correlated with occult nodal metastases. CCND1 amplification and cyclin D1 expression correlated with occult nodal metastases. Cyclin D1 expression was validated in an independent multicenter cohort, confirming the correlation with occult nodal metastases in early FOM cancers. Cyclin D1 is a predictive biomarker for occult nodal metastases in early FOM cancers. Prospective research on biopsy material should confirm these results before implementing its use in routine clinical practice. © 2016 Wiley Periodicals, Inc. Head Neck 39: 326-333, 2017. © 2016 Wiley Periodicals, Inc.

  12. Brain response to masked and unmasked facial emotions as a function of implicit and explicit personality self-concept of extraversion.

    Science.gov (United States)

    Suslow, Thomas; Kugel, Harald; Lindner, Christian; Dannlowski, Udo; Egloff, Boris

    2017-01-06

    Extraversion-introversion is a personality dimension referring to individual differences in social behavior. In the past, neurobiological research on extraversion was almost entirely based upon questionnaires which inform about the explicit self-concept. Today, indirect measures are available that tap into the implicit self-concept of extraversion which is assumed to result from automatic processing functions. In our study, brain activation while viewing facial expression of affiliation relevant (i.e., happiness, and disgust) and irrelevant (i.e., fear) emotions was examined as a function of the implicit and explicit self-concept of extraversion and processing mode (automatic vs. controlled). 40 healthy volunteers watched blocks of masked and unmasked emotional faces while undergoing functional magnetic resonance imaging. The Implicit Association Test and the NEO Five-Factor Inventory were applied as implicit and explicit measures of extraversion which were uncorrelated in our sample. Implicit extraversion was found to be positively associated with neural response to masked happy faces in the thalamus and temporo-parietal regions and to masked disgust faces in cerebellar areas. Moreover, it was positively correlated with brain response to unmasked disgust faces in the amygdala and cortical areas. Explicit extraversion was not related to brain response to facial emotions when controlling trait anxiety. The implicit compared to the explicit self-concept of extraversion seems to be more strongly associated with brain activation not only during automatic but also during controlled processing of affiliation relevant facial emotions. Enhanced neural response to facial disgust could reflect high sensitivity to signals of interpersonal rejection in extraverts (i.e., individuals with affiliative tendencies). Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

  13. Retrieval of temperature and pressure using broadband solar occultation: SOFIE approach and results

    Directory of Open Access Journals (Sweden)

    B. T. Marshall

    2011-05-01

    Full Text Available Measurement of atmospheric temperature as a function of pressure, T(P, is key to understanding many atmospheric processes and a prerequisite for retrieving gas mixing ratios and other parameters from solar occultation measurements. This paper gives a brief overview of the solar occultation measurement technique followed by a detailed discussion of the mechanisms that make the measurement sensitive to temperature. Methods for retrieving T(P using both broadband transmittance and refraction are discussed. Investigations using measurements of broadband transmittance in two CO2 absorption bands (the 4.3 and 2.7 μm bands and refractive bending are then presented. These investigations include sensitivity studies, simulated retrieval studies, and examples from SOFIE.

  14. Observing Tropospheric Water Vapor by Radio Occultation using the Global Positioning System

    Science.gov (United States)

    Kursinski, E. R.; Hajj, G. A.; Hardy, K. R.; Romans, L. J.; Schofield, J. T.

    1995-01-01

    Given the importance of water vapor to weather, climate and hydrology, global humidity observations from satellites are critical. At low latitudes, radio occultation observations of Earth's atmosphere using the Global Positioning System (GPS) satellites allow water vapor profiles to be retrieved with accuracies of 10 to 20% below 6 to 7 km altitude and approx. 5% or better within the boundary layer. GPS observations provide a unique combination of accuracy, vertical resolution (less than or equal to 1 km) and insensitivity to cloud and aerosol particles that is well suited to observations of the lower troposphere. These characteristics combined with the inherent stability of radio occultation observations make it an excellent candidate for the measurement of long term trends.

  15. Photometry of occultation candidate stars. I - Uranus 1985 and Saturn 1985-1991

    Science.gov (United States)

    French, L. M.; Morales, G.; Dalton, A. S.; Klavetter, J. J.; Conner, S. R.

    1985-01-01

    Photometric observations of five stars to be occulted by the rings around Uranus are presented. The four stars to be occulted by Saturn or its rings during the period 1985-1991 were also observed. The observations were carried out with a CCD detector attached to the Kitt Peak McGraw-Hill 1.30-m telescope. Landolt standards of widely ranging V-I color indices were used to determine the extinction coefficients, transformation coefficients, and zero points of the stars. Mean extinction coefficients are given for each night of observation. K magnitudes for each star were estimated on the basis of the results of Johnson (1967). The complete photometric data set is given in a series of tables.

  16. Lunar occultation of Saturn. II - The normal reflectance of Rhea, Titan, and Iapetus

    Science.gov (United States)

    Elliot, J. L.; Dunham, E. W.; Veverka, J.; Goguen, J.

    1978-01-01

    An inversion procedure to obtain the reflectance of the central region of a satellite's disk from lunar occultation data is presented. The scheme assumes that the limb darkening of the satellite depends only on the radial distance from the center of the disk. Given this assumption, normal reflectances can be derived that are essentially independent of the limb darkening and the diameter of the satellite. The procedure has been applied to our observations of the March 1974 lunar occultation of Tethys, Dione, Rhea, Titan, and Iapetus. In the V passband we derive the following normal reflectances: Rhea (0.97 plus or minus 0.20), Titan (0.24 plus or minus 0.03), Iapetus, bright face (0.60 plus or minus 0.14). For Tethys and Dione the values derived have large uncertainties, but are consistent with our result for Rhea.

  17. The Taiwanese-American occultation survey project stellar variability. III. Detection of 58 new variable stars

    Energy Technology Data Exchange (ETDEWEB)

    Ishioka, R.; Wang, S.-Y.; Zhang, Z.-W.; Lehner, M. J.; Cook, K. H.; King, S.-K.; Lee, T.; Marshall, S. L.; Schwamb, M. E.; Wang, J.-H.; Wen, C.-Y. [Institute of Astronomy and Astrophysics, Academia Sinica, 11F of Astronomy-Mathematics Building, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China); Alcock, C.; Protopapas, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Axelrod, T. [Steward Observatory, 933 North Cherry Avenue, Room N204, Tucson, AZ 85721 (United States); Bianco, F. B. [Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Byun, Y.-I. [Department of Astronomy and University Observatory, Yonsei University, 134 Shinchon, Seoul 120-749 (Korea, Republic of); Chen, W. P.; Ngeow, C.-C. [Institute of Astronomy, National Central University, No. 300, Jhongda Road, Jhongli City, Taoyuan County 320, Taiwan (China); Kim, D.-W. [Max Planck Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); Rice, J. A., E-mail: ishioka@asiaa.sinica.edu.tw [Department of Statistics, University of California Berkeley, 367 Evans Hall, Berkeley, CA 94720 (United States)

    2014-04-01

    The Taiwanese-American Occultation Survey project is designed for the detection of stellar occultations by small-size Kuiper Belt Objects, and it has monitored selected fields along the ecliptic plane by using four telescopes with a 3 deg{sup 2} field of view on the sky since 2005. We have analyzed data accumulated during 2005-2012 to detect variable stars. Sixteen fields with observations of more than 100 epochs were examined. We recovered 85 variables among a total of 158 known variable stars in these 16 fields. Most of the unrecovered variables are located in the fields observed less frequently. We also detected 58 variable stars which are not listed in the International Variable Star Index of the American Association of Variable Star Observers. These variable stars are classified as 3 RR Lyrae, 4 Cepheid, 1 δ Scuti, 5 Mira, 15 semi-regular, and 27 eclipsing binaries based on the periodicity and the profile of the light curves.

  18. Incidence of occult leiomyosarcoma in presumed morcellation cases: a database study.

    Science.gov (United States)

    Rodriguez, Ana M; Asoglu, Mehmet R; Sak, Muhammet Erdal; Tan, Alai; Borahay, Mostafa A; Kilic, Gokhan S

    2016-02-01

    Our objective was to estimate the incidence of uterine leiomyosarcoma in patients with leiomyomas following laparoscopic supracervical hysterectomy and myomectomy procedures. For this study, we analyzed records of 13,964 women aged 25-64 years who underwent laparoscopic supracervical hysterectomies or myomectomies for leiomyomas from 2002 to 2011 using Clinformatics DataMart. Patient records were divided into two groups: history of laparoscopic supracervical hysterectomy and history of myomectomy. Subjects were tracked to identify diagnosis of leiomyosarcoma within 1 year of the procedure. We analyzed data from the 25-39, 40-49, and 50-64 age brackets. Evidence was obtained from a cohort study from national private insurance claims in the US. Our results showed the incidence of occult leiomyosarcoma developing within 1 year following supracervical hysterectomy using a laparoscopic-assisted approach are 9.8, 10.7, and 33.4 per 10,000 for the 25-39, 40-49, and 50-64 age brackets, respectively; the overall incidence rate is 13.1 per 10,000. The incidence rate of occult leiomyosarcoma developing within 1 year following myomectomy using a laparoscopic-assisted approach are 0.0, 33.8, and 90.1 per 10,000 for the 25-39, 40-49, and 50-64 age brackets, respectively; the overall incidence rate is 17.3 per 10,000. Our analysis shows the overall risk of being diagnosed with occult leiomyosarcoma is 12.9 per 10,000 in laparoscopic-assisted supracervical hysterectomy and myomectomy for patients younger than 49. There is no evidence of occult leiomyosarcoma 1 year after operation for patients younger than 40 who underwent laparoscopic myomectomy. Copyright © 2015. Published by Elsevier Ireland Ltd.

  19. The occult nature of intramedullary spinal cord metastases from renal cell carcinoma.

    LENUS (Irish Health Repository)

    Zakaria, Zaitun

    2012-01-01

    Renal cell carcinomas (RCC) are characterised by a tendency to metastasise widely, often while remaining occult. Intramedullary spinal cord metastases (ISCM) from RCC may be the presenting feature of the disease or present at any time in the disease course. This case report discusses an ISCM from RCC which became manifested at the time of resection of the primary tumour. We review the literature published on ISCM from RCC from 1990 to date comparing disease characteristics and presentations.

  20. High prevalence of occult left heart disease in scleroderma-pulmonary hypertension.

    Science.gov (United States)

    Fox, Benjamin D; Shimony, Avi; Langleben, David; Hirsch, Andrew; Rudski, Lawrence; Schlesinger, Robert; Eisenberg, Mark J; Joyal, Dominique; Hudson, Marie; Boutet, Kim; Serban, Alexandrina; Masetto, Ariel; Baron, Murray

    2013-10-01

    Our study aimed to determine the prevalence of occult left-heart disease in patients with scleroderma and pulmonary hypertension. In patients with pulmonary hypertension (mean pulmonary artery pressure (mean PAP)≥25 mmHg), differentiation between pre- and post-capillary pulmonary hypertension has been made according to pulmonary artery wedge pressure (PAWP) less than or more than 15 mmHg, respectively. We performed a retrospective chart review of 107 scleroderma patients. All patients with suspected pulmonary hypertension had routine right or left heart catheterisation with left ventricular end-diastolic pressure (LVEDP) measurement pre-/post-fluid challenge. We extracted demographic, haemodynamic and echocardiographic data. Patients were classified into one of four groups: haemodynamically normal (mean PAP15 mmHg); occult PVH (mean PAP≥25 mmHg, PAWP≤15 mmHg, LVEDP>15 mmHg before or after fluid challenge); and pulmonary arterial hypertension (PAH) (mean PAP≥25 mmHg, PAWP≤15 mmHg and LVEDP≤15 mmHg before or after fluid challenge). 53 out of 107 patients had pulmonary hypertension. Based on the PAWP-based definition, 29 out of 53 had PAH and 24 out of 53 had PVH. After considering the resting and post-fluid-challenge LVEDP, 11 PAH patients were reclassified as occult PVH. The occult PVH group was haemodynamically, echocardiographically and demographically closer to the PVH group than the PAH group. PVH had high prevalence in our scleroderma-pulmonary hypertension population. Distinguishing PAH from PVH with only PAWP may result in some PVH patients being misclassified as having PAH.

  1. Significance of occult hbv infection in patients with chronic hepatitis c

    International Nuclear Information System (INIS)

    Anwar, W.; Sarwar, M.; Saif, M.; Hussain, A.B.; Tariq, W.Z.

    2006-01-01

    Objective: To determine the frequency of occurrence of occult Hepatitis B infection in chronic hepatitis C patients and its impact (if any) on the effectivity of standard chronic hepatitis C treatment. Design: Quasi-experimental study. Place and Duration of Study: The study was conducted at the Department of Medicine, Military Hospital, Rawalpindi, and Virology Department, Armed Forces Institute of Pathology, Rawalpindi, for a period of nine months from January 2003 to September 2003. Patients and Methods: This study was conducted on 30 HBsAg negative patients with chronic hepatitis C liver disease who were receiving combination therapy with interferon and ribavirin. Occult hepatitis B infection was assessed by carrying out HBV DNA by polymerase chain reaction (PCR) in the sera of these patients. Markers of previous hepatitis B infection Le; anti-HBs and total anti-HBc antibodies were also tested. Response to treatment for hepatitis C (with interferon and ribavirin) was assessed at the end of six months of therapy by measuring ALT levels and HCV RNA by PCR in the serum. Results: In our study only one patient (3.33%) was found to be harbouring HBV DNA in the serum detectable by PCR, with markers of previous HBV infection (both anti HBc antibodies and anti HBs antibodies were positive). A total 14 patients (46.67%) had markers of previous HBV infection, while 16 patients (53.33%) had no such sero markers. Twenty five out of 30 patients (83.33%) responded to treatment and 5 (16.66%) turned out to be non-responders. The single case of occult hepatitis B detected in this study responded to hepatitis C treatment. Conclusion: Occult hepatitis B is not a common occurrence in chronic hepatitis C patients and it did not alter the outcome of treatment for hepatitis C in our study. (author)

  2. Outcome of early detection and radiotherapy for occult spinal cord compression

    International Nuclear Information System (INIS)

    Venkitaraman, Ramachandran; Barbachano, Yolanda; Dearnaley, David P.; Parker, Christopher C.; Khoo, Vincent; Huddart, Robert A.; Eeles, Rosalind; Horwich, Alan; Aslam Sohaib, S.

    2007-01-01

    Retrospective analysis in 150 patients with metastatic prostate cancer was conducted to determine whether early detection with MRI spine and treatment of clinically occult spinal cord compromise (SCC) facilitate preservation of neurologic function. Our results suggest that prophylactic radiotherapy for patients with back pain or radiological SCC without neurologic deficit may facilitate preservation of neurologic function. Thus MRI surveillance for SCC may be important for prostate cancer patients with bone metastases

  3. Anemia and thrombocytopenia as initial symptoms of occult breast cancer with bone marrow metastasis

    OpenAIRE

    Liu, Lulu; Zhang, Jingjing; Chen, Mingtai; Ren, Saisai; Liu, Haihui; Zhang, Hao

    2017-01-01

    Abstract Rationale: Occult breast cancer (OBC) is a rare type of breast cancer without any symptoms in the breast and is often presented with initial symptoms of axillary lymph node metastasis or other metastases. The low incidence rates of OBC make it a great challenge to diagnose and cure. Patient concerns: Our case was a 58-year-old female affected by dizziness and fatigue for nearly a month. Blood tests revealed anemia and thrombocytopenia, and pathological results of a bone marrow biopsy...

  4. Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers.

    Science.gov (United States)

    O'Grady, M R; O'Sullivan, M L; Minors, S L; Horne, R

    2009-01-01

    Angiotensin converting enzyme inhibitors (ACEIs) are recommended in people to treat asymptomatic (occult) dilated cardiomyopathy (DCM). Efficacy of therapy in occult DCM in dogs is unknown. ACEIs, specifically benazepril hydrochloride (BH), will delay the onset of overt DCM in Doberman Pinschers. Ninety-one Doberman Pinschers were studied, 57 dogs received BH, and 34 dogs no ACEI. Retrospective study of the medical records of all Doberman Pinschers with occult DCM that received BH or no ACEI between April 1989 and February 2003. Two criteria of left ventricular enlargement were used for enrollment: one independent of body weight (BW) (C1) and the other indexed to BW (C2). Cox proportional hazards analyses were used to identify variables associated with the onset of overt DCM. On univariate analysis the median time to onset of overt DCM was significantly longer for the benazepril group (for C1: 425 days for BH, 95% confidence interval [CI] 264-625 days; 339 days for no ACEI, CI 172-453 days, P= .02; for C2: 454 days for BH, CI 264-628 days; 356 days for no ACEI, CI 181-547 days, P= .02). The hazard ratio (HR) (benazepril/no ACEI) was 0.57, CI 0.35-0.94, P= .03 for C1; HR = 0.56, CI 0.34-0.93, P= .02 for C2. On multivariate analysis, BH significantly delayed onset of overt DCM (HR [benazepril/no ACEI] = 0.45, CI 0.26-0.78, P < .01, for C1; HR = 0.36, CI 0.21-0.63, P < .01, for C2). BH in particular and ACEIs in general might delay the progression of occult DCM. Prospective studies are warranted to test this theory.

  5. Thermal structure of intense convective clouds derived from GPS radio occultations

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Randel, W. J.; Ho, S. -P.

    2012-01-01

    Thermal structure associated with deep convective clouds is investigated using Global Positioning System (GPS) radio occultation measurements. GPS data are insensitive to the presence of clouds, and provide high vertical resolution and high accuracy measurements to identify associated temperature...... behavior. Deep convective systems are identified using International Satellite Cloud Climatology Project (ISCCP) satellite data, and cloud tops are accurately measured using Cloud-Aerosol Lidar with Orthogonal Polarization (CALIPSO) lidar observations; we focus on 53 cases of near-coincident GPS...

  6. Thermal structure of intense convective clouds derived from GPS radio occultations

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Randel, W. J.; Ho, S.-P.

    2011-01-01

    Thermal structure associated with deep convective clouds is investigated using Global Positioning System (GPS) radio occultation measurements. GPS data are insensitive to the presence of clouds, and provide high vertical resolution and high accuracy measurements to identify associated temperature...... behavior. Deep convective systems are identified using International Satellite Cloud Climatology Project (ISCCP) satellite data, and cloud tops are accurately measured using Cloud-Aerosol Lidar with Orthogonal Polarization (CALIPSO) lidar observations; we focus on 53 cases of near-coincident GPS...

  7. The prevalence of visible and/or occult blood on anesthesia and monitoring equipment.

    Science.gov (United States)

    Perry, S M; Monaghan, W P

    2001-02-01

    The Occupational Safety and Health Administration (OSHA) and the Centers for Disease Control and Prevention (CDC) have attempted to stop the spread of blood-borne pathogens by issuing several recommendations and regulations. However, unless healthcare workers comply with these standards, they are not effective. In the anesthesia care environment, the anesthetist is responsible for ensuring that the equipment is clean, and disinfected, before use. We studied the prevalence of visible and occult blood on 6 types of anesthesia and monitoring equipment identified as ready for use in 28 operating suites, in 2 facilities. The sample consisted of 336 observations of the 6 types of equipment. The equipment was inspected for visible blood and then tested for occult blood using a 3-stage phenolphthalein test. Of the 336 observations, 110 (32.7%), were positive for occult blood with only 6 showing visible blood. The presence of blood on this equipment may be in direct violation of the OSHA Blood-borne Pathogen Standard and the infection control guidelines of the American Association of Nurse Anesthetists. Furthermore, the presence of blood on this equipment may increase the risk for nosocomial and occupational exposure to viral and bacterial pathogens. Recommendations were made to decrease the risks from this contamination by redesigning equipment, increasing the use of disposable equipment, and ensuring compliance with effective infection control practices.

  8. The use of MRI and CT in Imaging Occult Hip Fractures

    Directory of Open Access Journals (Sweden)

    Obadă B.

    2014-11-01

    Full Text Available Diagnosis of hip fractures is particularly important due to the high dependence on the integrity of this structure for people to function in their daily lives. Left unrecognized, patients face increasing morbidity and mortality as time from the original injury lengthens. A delay of just 2 days in surgical treatment for an acute hip fracture doubles mortality. In addition, an unrecognized non-displaced fracture may displace, requiring surgery of much higher risk. This may be part of the reason that the most frequent lawsuit against Emergency Physicians is for missed orthopedic injury. We reviewed the use of MRI and CT for occult hip fractures (OHF detection at a major urban trauma unit. Our study is a retrospective review. Inclusion criteria: all patients presenting to the Emergency Clinical Hospital of Constanta with a suspected, posttraumatic, occult hip fracture, over a 5 years period were included. All patients had negative initial radiographs and underwent further imaging with either CT or MRI. A total of 185 cases meeting the inclusion criteria were identified. 72 occult hip fractures were detected with both imaging modalities. Although MRI certainly enables greater image detail, in our experience both modalities are able to provide satisfactory fracture characterization. The choice of imaging should be determined by availability and indication. MRI provides superior imaging of soft tissue but is less sensitive for degenerative changes in presence of bone edema.

  9. Verify Occulter Deployment Tolerances as Part of NASA's Technology Development for Exoplanet Missions

    Science.gov (United States)

    Kasdin, N. J.; Shaklan, S.; Lisman, D.; Thomson, M.; Webb, D.; Cady, E.; Marks, G. W.; Lo, A.

    2013-01-01

    In support of NASA's Exoplanet Exploration Program and the Technology Development for Exoplanet Missions (TDEM), we recently completed a 2 year study of the manufacturability and metrology of starshade petals. An external occult is a satellite employing a large screen, or starshade, that flies in formation with a spaceborne telescope to provide the starlight suppression needed for detecting and characterizing exoplanets. Among the advantages of using an occulter are the broadband allowed for characterization and the removal of light before entering the observatory, greatly relaxing the requirements on the telescope and instrument. This poster presents the results of our successful first TDEM that demonstrated an occulter petal could be built and measured to an accuracy consistent with close to 10^-10 contrast. We also present the progress in our second TDEM to demonstrate the next critical technology milestone: precision deployment of the central truss and petals to the necessary accuracy. We have completed manufacture of four sub-scale petals and a central hub to fit with an existing deployable truss. We show the plans for repeated stow and deploy tests of the assembly and the metrology to confirm that each deploy repeatably meets the absolute positioning requirements of the petals (better than 1.0 mm).

  10. Verifying occulter deployment tolerances as part of NASA's technology development for exoplanet missions

    Science.gov (United States)

    Kasdin, N. J.; Lisman, D.; Shaklan, S.; Thomson, M.; Webb, D.; Cady, E.; Marks, G. W.; Lo, A.

    2013-09-01

    An external occulter is a satellite employing a large screen, or starshade, that flies in formation with a spaceborne telescope to provide the starlight suppression needed for detecting and characterizing exoplanets. Among the advantages of using an occulter are the broadband allowed for characterization and the removal of light before entering the observatory, greatly relaxing the requirements on the telescope and instrument. In support of NASA's Exoplanet Exploration Program and the Technology Development for Exoplanet Missions (TDEM), we recently completed a 2 year study of the manufacturability and metrology of starshade petals. In this paper we review the results of that successful first TDEM which demonstrated an occulter petal could be built and measured to an accuracy consistent with close to 10-10 contrast. We then present the results of our second TDEM to demonstrate the next critical technology milestone: precision deployment of the central truss and petals to the necessary accuracy. We show the deployment of an existing deployable truss outfitted with four sub-scale petals and a custom designed central hub.

  11. The Centaur Chariklo and its rings system from stellar occultations in 2017

    Science.gov (United States)

    Leiva, Rodrigo; Sicardy, Bruno; Camargo, Julio; Ortiz, Jose Luis; Berard, Diane; Desmars, Josselin; Chariklo Occultations Team; Rio Group; Lucky Star Occultation Team; Granada Occultation Team

    2017-10-01

    A stellar occultation in June 3, 2013 revealed the presence of a dense ring system around the Centaur object (10199) Chariklo (Braga-Ribas et al., Nature 2014). Subsequent analysis of occultation data and long-term photometric variations indicate that Chariklo's body is elongated (Leiva et al. 2017, submitted) and that the main ring exhibits significant longitudinal variations of the radial width (Bérard et al. 2017, in press). We report three multi-chord high-quality stellar occultation by Chariklo on April 9, 2017 and June 22, 2017 from Namibia, and July 23 2017 from South America. The analysis of this new data set is underway, but preliminary results are consistent with triaxial ellipsoidal models. From this analysis we will:-present refined models for the size and shape of Chariklo's main body andevaluate the heights and slopes of its topographic features.-give constraints on the longitudinal width variations of Chariklo's rings andexplore the possibility to obtain the rings apsidal precession rate.Chariklo's shape and topography have strong consequences on the dynamics of the rings through Lindblad-type resonances between mean motion of the ring particles and the spin of the main body, while the rings precession rate gives constraints on the dynamical oblateness of the main body.**Part of the research leading to these results has received funding from the European Research Council under the European Community’s H2020 (2014-2020/ ERC Grant Agreement n 669416 ”LUCKY STAR”).

  12. First lunar occultation results from the 2.4 m Thai national telescope equipped with ULTRASPEC

    Energy Technology Data Exchange (ETDEWEB)

    Richichi, A.; Irawati, P.; Soonthornthum, B. [National Astronomical Research Institute of Thailand, 191 Siriphanich Building, Huay Kaew Road, Suthep, Muang, Chiang Mai 50200 (Thailand); Dhillon, V. S. [Department of Physics and Astronomy, University of Sheffield, Sheffield S3 7RH (United Kingdom); Marsh, T. R., E-mail: andrea4work@gmail.com [Department of Physics, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL (United Kingdom)

    2014-11-01

    The recently inaugurated 2.4 m Thai National Telescope (TNT) is equipped with, among other instruments, the ULTRASPEC low-noise, frame-transfer EMCCD camera. At the end of its first official observing season, we report on the use of this facility to record high time resolution imaging using small detector subarrays with a sampling as fast as several 10{sup 2} Hz. In particular, we have recorded lunar occultations of several stars that represent the first contribution to this area of research made from Southeast Asia with a telescope of this class. Among the results, we discuss an accurate measurement of α Cnc, which has been reported previously as a suspected close binary. Attempts by several authors to resolve this star have so far met with a lack of unambiguous confirmation. With our observation we are able to place stringent limits on the projected angular separation (<0.''003) and brightness (Δm > 5) of a putative companion. We also present a measurement of the binary HR 7072, which extends considerably the time coverage available for its yet undetermined orbit. We discuss our precise determination of the flux ratio and projected separation in the context of other available data. We conclude by providing an estimate of the performance of ULTRASPEC at TNT for lunar occultation work. This facility can help to extend the lunar occultation technique in a geographical area where no comparable resources were available until now.

  13. Astrometry of the Orcus/Vanth occultation on UT 7 March 2017

    Science.gov (United States)

    Bosh, Amanda S.; Zuluaga, Carlos; Levine, Stephen; Sickafoose, Amanda A.; Genade, Anja; Schindler, Karsten; Lister, Tim; Person, Michael J.

    2017-10-01

    On UT 7 March 2017, Orcus was predicted to occult a star with m=14.3. Observations were made at five observatories: the 0.6-m Astronomical Telescope of the University of Stuttgart (ATUS) at Sierra Remote Observatories (SRO), California; Las Cumbres Observatory’s 1-m telescope (ELP) at McDonald Observatory, Fort Davis, Texas; NASA’s 3-m InfraRed Telescope Facility (IRTF) on Mauna Kea, Hawaii; the 4.1-m Southern Astrophysical Research telescope (SOAR) on Cerro Pachón, Chile; and the 0.6-m Southeastern Association for Research in Astronomy telescope (SARA-CT) at Cerro Tololo, Chile. While observations at all sites were successful, only two—ELP and IRTF—observed solid-body occultation signatures. We will discuss the various predictions for this event and the reasons for the differences among them, including an offset of 130 mas for the star position from the position in the Gaia catalog. The sum of the positive and negative detections place constraints on the geometry of the Orcus/Vanth system, and we present our astrometric results for the geometric solution for this occultation. The implications of the light curve analyses are presented by Sickafoose et al., this conference.

  14. Usefullness of routine use of fecal occult blood test in a hospital setting

    Directory of Open Access Journals (Sweden)

    Simona Ravnik

    2006-12-01

    Full Text Available Background: Fecal occult blood test, hematest, is a well excepted non-invasive method used for detecting different diseases of the gastrointestinal tract. It was proven in different randomized studies that usage of this simple method may facilitate further diagnostic and therapeutic treatment.Patients and methods: The retrospective analysis includes patients, which were admitted to the gastroenterological and endoscopy department of the General hospital Maribor in the last quarter of the year 2005. In all patients fecal occult blood test was performed.Results: We examined 200 patients, 104 women and 96 men, average age 63.9 years, SD±16.9, ranging from 21 to 97 years. Positive hematest was discovered in 76 patients (38 %. The source of hemorrhage from the upper digestive tract was confirmed in 37 patients (48.6 % of all positive tests and from the lower digestive tract in 34 patients (46 % of all positive tests. The most frequent causes of hemorrhage from the lower digestive tract were chronic inflammatory bowel disease (13.1 % of all positive tests, colorectal cancer (10.5 % and polyps (6.6 %. The source of hemorrhage was not located in five patients (6.6 % of all positive tests despite the accurate diagnostic procedure.Conclusions: By performing a fecal occult blood screening in non-symptomatic patients, we can make an essential step towards discovering different gastrointestinal diseases, even colorectal cancer in its early, limited form, when the effect of treatment is greatest.

  15. TITAN’S UPPER ATMOSPHERE FROM CASSINI/UVIS SOLAR OCCULTATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Capalbo, Fernando J.; Bénilan, Yves [Laboratoire Inter-Universitaire des Systèmes Atmosphériques (LISA), UMR 7583 du CNRS, Universités Paris Est Créteil (UPEC) and Paris Diderot - UPD, 61 avenue du Général de Gaulle, F-94010, Créteil Cédex (France); Yelle, Roger V.; Koskinen, Tommi T., E-mail: fernando.capalbo@lisa.u-pec.fr [Lunar and Planetary Laboratory, University of Arizona, 1629 E. University Blvd., Tucson, AZ 85721 (United States)

    2015-12-01

    Titan’s atmosphere is composed mainly of molecular nitrogen, methane being the principal trace gas. From the analysis of 8 solar occultations measured by the Extreme Ultraviolet channel of the Ultraviolet Imaging Spectrograph (UVIS) on board Cassini, we derived vertical profiles of N{sub 2} in the range 1100–1600 km and vertical profiles of CH{sub 4} in the range 850–1300 km. The correction of instrument effects and observational effects applied to the data are described. We present CH{sub 4} mole fractions, and average temperatures for the upper atmosphere obtained from the N{sub 2} profiles. The occultations correspond to different times and locations, and an analysis of variability of density and temperature is presented. The temperatures were analyzed as a function of geographical and temporal variables, without finding a clear correlation with any of them, although a trend of decreasing temperature toward the north pole was observed. The globally averaged temperature obtained is (150 ± 1) K. We compared our results from solar occultations with those derived from other UVIS observations, as well as studies performed with other instruments. The observational data we present confirm the atmospheric variability previously observed, add new information to the global picture of Titan’s upper atmosphere composition, variability, and dynamics, and provide new constraints to photochemical models.

  16. Cassini UVIS solar occultations by Saturn's F ring and the detection of collision-produced micron-sized dust

    Science.gov (United States)

    Becker, Tracy M.; Colwell, Joshua E.; Esposito, Larry W.; Attree, Nicholas O.; Murray, Carl D.

    2018-05-01

    We present an analysis of eleven solar occultations by Saturn's F ring observed by the Ultraviolet Imaging Spectrograph (UVIS) on the Cassini spacecraft. In four of the solar occultations we detect an unambiguous signal from diffracted sunlight that adds to the direct solar signal just before or after the occultations occur. The strongest detection was a 10% increase over the direct signal that was enabled by the accidental misalignment of the instrument's pointing. We compare the UVIS data with images of the F ring obtained by the Cassini Imaging Science Subsystem (ISS) and find that in each instance of an unambiguous diffraction signature in the UVIS data, the ISS data shows that there was a recent disturbance in that region of the F ring. Similarly, the ISS images show a quiescent region of the F ring for all solar occultations in which no diffraction signature was detected. We therefore conclude that collisions in the F ring produce a population of small ring particles that can produce a detectable diffraction signal immediately interior or exterior to the F ring. The clearest example of this connection comes from the strong detection of diffracted light in the 2007 solar occultation, when the portion of the F ring that occulted the Sun had suffered a large collisional event, likely with S/2004 S 6, several months prior. This collision was observed in a series of ISS images (Murray et al., 2008). Our spectral analysis of the data shows no significant spectral features in the F ring, indicating that the particles must be at least 0.2 μm in radius. We apply a forward model of the solar occultations, accounting for the effects of diffracted light and the attenuated direct solar signal, to model the observed solar occultation light curves. These models constrain the optical depth, radial width, and particle size distribution of the F ring. We find that when the diffraction signature is present, we can best reproduce the occultation data using a particle population

  17. Atmospheric gravity wave detection following the 2011 Tohoku earthquakes combining COSMIC occultation and GPS observations

    Science.gov (United States)

    Yan, X.; Tao, Y.; Xia, C.; Qi, Y.; Zuo, X.

    2017-12-01

    Several studies have reported the earthquake-induced atmospheric gravity waves detected by some new technologies such as airglow (Makela et al., 2011), GOCE (Garcia et al., 2013), GRACE (Yang et al., 2014), F3/C radio occultation sounding (Coïsson et al., 2015). In this work, we collected all occultation events on 11 March, and selected four events to analyze at last. The original and filtered podTEC is represented as function of the altitude of the impact parameter and UT of the four events. Then, the travel time diagrams of filtered podTEC derived from the events were analyzed. The occultation signal from one event (marked as No.73) is consistent with the previous results reported by Coïsson. 2015, which is corresponds to the ionospheric signal induced from tsunami gravity wave. What is noticeable, in this work, is that three occultation events of No.403, 77 and 118 revealed a disturbance of atmospheric gravity wave with velocity 300m/s, preceding the tsunami. It would probably be correspond to the gravity waves caused by seismic rupture but not tsunami. In addition, it can be seen that the perturbation height of occultation observation TEC is concentrated at 200-400km, corresponding ionosphere F region. The signals detected above are compared with GPS measurements of TEC from GEONET and IGS. From GPS data, traveling ionospheric disturbances were observed spreading out from the epicenter as a quasi-circular propagation pattern with the time. Exactly, we observed an acoustic wave coupled with Rayleigh wave starting from the epicenter with a speed of 3.0km/s and a superimposed acoustic-gravity wave moving with a speed of 800m/s. The acoustic-gravity wave generated at the epicenter and gradually attenuated 800km away, then it is replaced by a gravity wave coupled with the tsunami that moves with a speed of between 100 and 300m/s. It is necessary to confirm the propagation process of the waves if we attempt to evaluate the use of ionospheric seismology as a

  18. Occult hepatitis B virus coinfection in HIV-positive African migrants to the UK: a point prevalence study.

    Science.gov (United States)

    Chadwick, D; Doyle, T; Ellis, S; Price, D; Abbas, I; Valappil, M; Geretti, A M

    2014-03-01

    Occult (surface antigen-negative/DNA-positive) hepatitis B virus (HBV) infection is common in areas of the world where HBV is endemic. The main objectives of this study were to determine the prevalence of occult HBV infection in HIV-infected African migrants to the UK and to determine factors associated with occult coinfection. This anonymized point-prevalence study identified Africans attending three HIV clinics, focussing on patients naïve to antiretroviral therapy (ART). Stored blood samples were tested for HBV DNA. Prevalence was calculated in the entire cohort, as well as in subpopulations. Risk factors for occult HBV coinfection were identified using logistic regression analysis. Among 335 HIV-positive African migrants, the prevalence of occult HBV coinfection was 4.5% [95% confidence interval (CI) 2.8-7.4%] overall, and 6.5% (95% CI 3.9-10.6%) and 0.8% (95% CI 0.2-4.6%) in ART-naïve and ART-experienced patients, respectively. Among ART-naïve anti-HBV core (anti-HBc)-positive patients, the prevalence was 16.4% (95% CI 8.3-25.6%). The strongest predictor of occult coinfection was anti-HBc positivity [odds ratio (OR) 7.4; 95% CI 2.0-27.6]. Median HBV DNA and ALT levels were 54 IU/mL [interquartile range (IQR) 33-513 IU/mL] and 22 U/L (IQR 13-27 U/L), respectively. Occult HBV coinfection remains under-diagnosed in African HIV-infected patients in the UK. Given the range of HBV DNA levels observed, further studies are warranted to determine its clinical significance and to guide screening strategies and ART selection in these patients. © 2013 British HIV Association.

  19. Overlap of Post-obstructive Diuresis and Unmasked Diabetes Insipidus in a Case of IgG4-related Retroperitoneal Fibrosis and Tuberoinfundibular Hypophysitis: A Case Report and Review of the Literature.

    Science.gov (United States)

    Sasaki Yatabe, Midori; Watanabe, Kimio; Hayashi, Yoshimitsu; Yatabe, Junichi; Morimoto, Satoshi; Ichihara, Atsuhiro; Nakayama, Masaaki; Watanabe, Tsuyoshi

    The clinical picture of IgG4-related disease (IgG4-RD) is diverse because various organs can be affected. We describe the case of a 56-year-old man with acute renal failure and tuberoinfundibular hypophysitis due to IgG4-RD. Steroid therapy lowered the serum IgG4 level and ameliorated renal dysfunction, bilateral hydronephrosis and retroperitoneal fibrosis. However, polyuria from post-obstructive diuresis and unmasked central diabetes insipidus ensued. The patient's polyuria continued despite the administration of a therapeutic dose of glucocorticoid; the patient's pituitary swelling and anterior pituitary dysfunction were partially ameliorated. The pituitary swelling recurred seven months later. In patients with IgG4-RD, the manifestation of polyuria after steroid therapy should prompt suspicion of post-obstructive diuresis and the unmasking of central diabetes insipidus.

  20. Occultism in an African context: a case for the Vhavenda-speaking people of the Limpopo Province

    Directory of Open Access Journals (Sweden)

    T. D. Mashau

    2007-07-01

    Full Text Available Occultism in Africa is as old as the primal religion itself, or what came to be known as African Traditional Religion (ATR in mo- dern times. It dates back to time immemorial. Occultism in Africa has taken various forms and has manifested in different ways over the ages, i.e. spiritism, divination, witchcraft and ma- gic. The underlying premise of African occultism is the belief in a spiritual world with spiritual forces that have power to inflict harm on the living. In the traditional African worldview suffering of every sort – illness, barrenness, drought and death – is nor- mally explained in personal terms: “there is always somebody”. This “somebody” often belongs to the world of the occult: a “spirit” has brought pain to human beings and must therefore be repelled or accommodated. This is very common among the Vhavenda-speaking people of the Limpopo Province. This ar- ticle seeks to investigate how occultism is practised among these people and to provide a reformed perspective as to how people who are suffering under demonic attacks can be helped. Contrary to other Christian traditions that see exorcism as the only way out, reformed theology suggests a missio-pastoral approach in dealing with the problem.

  1. Spatial patterns of whole brain grey and white matter injury in patients with occult spastic diplegic cerebral palsy.

    Science.gov (United States)

    Mu, Xuetao; Nie, Binbin; Wang, Hong; Duan, Shaofeng; Zhang, Zan; Dai, Guanghui; Ma, Qiaozhi; Shan, Baoci; Ma, Lin

    2014-01-01

    Spastic diplegic cerebral palsy (SDCP) is a common type of cerebral palsy (CP), which presents as a group of motor-impairment syndromes. Previous conventional MRI studies have reported abnormal structural changes in SDCP, such as periventricular leucomalacia. However, there are roughly 27.8% SDCP patients presenting normal appearance in conventional MRI, which were considered as occult SDCP. In this study, sixteen patients with occult SDCP and 16 age- and sex-matched healthy control subjects were collected and the data were acquired on a 3T MR system. We applied voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis to investigate whole brain grey and white matter injury in occult SDCP. By using VBM method, the grey matter volume reduction was revealed in the bilateral basal ganglia regions, thalamus, insula, and left cerebral peduncle, whereas the white matter atrophy was found to be located in the posterior part of corpus callosum and right posterior corona radiata in the occult SDCP patients. By using TBSS, reduced fractional anisotropy (FA) values were detected in multiple white matter regions, including bilateral white matter tracts in prefrontal lobe, temporal lobe, internal and external capsule, corpus callosum, cingulum, thalamus, brainstem and cerebellum. Additionally, several regions of white matter tracts injury were found to be significantly correlated with motor dysfunction. These results collectively revealed the spatial patterns of whole brain grey and white matter injury in occult SDCP.

  2. Clinical features of secondary glaucoma caused by lens suspensory ligament laxity or occult subluxation

    Directory of Open Access Journals (Sweden)

    Yi Ma

    2018-04-01

    Full Text Available AIM: To investigate the clinical characteristics of secondary glaucoma caused by lens suspensory ligament laxity or occult subluxation, and to analyze the influence of operation on visual acuity and intraocular pressure(IOP. METHODS: Totally 38 cases(38 eyesof the secondary glaucoma caused by lens suspensory ligament laxity or occult subluxation in ophthalmology department of our hospital from December 2014 to December 2016 were enrolled and their medical records were analyzed retrospectively to observe the clinical characteristics of glaucoma. Preoperative mydriasis was carried out and surgical methods were chosen according to the lenses location and extent of suspensory ligament. Preoperative and postoperative anterior chamber depth, corneal endothelial cell density, IOP, visual field, visual acuity and complications were analyzed. RESULTS: The average intraocular pressure was 18.17±1.43mmHg at postoperatively 10d, which was significantly lower than 38.77±2.45mmHg before operation, the difference had statistical significance(PP>0.05. The postoperative anterior chamber depth was 2.45±0.44mm, which was significantly higher than 1.23±0.35mm before operation, the difference had statistical significance(P2 and decreased significantly, compared with 1735.32±340.32/mm2 before operation, the difference had statistical significance(PCONCLUSION: Clinical symptoms and signs of secondary glaucoma in patients with lens suspensory ligament laxity or occult subluxation are more complex, which needs to be distinguished with other types of glaucoma in clinical treatment, and its surgical methods shall be chosen according to different suspensory ligament site and lens subluxation scope.

  3. Prognosis for Mammographically Occult, Early-Stage Breast Cancer Patients Treated With Breast-Conservation Therapy

    International Nuclear Information System (INIS)

    Yang, Tzu-I. J.; Yang Qifeng; Haffty, Bruce G.; Moran, Meena S.

    2010-01-01

    Purpose: To compare mammographically occult (MamOcc) and mammographically positive (MamPos) early-stage breast cancer patients treated with breast-conservation therapy (BCT), to analyze differences between the two cohorts. Methods and Materials: Our two cohorts consisted of 214 MamOcc and 2168 MamPos patients treated with BCT. Chart reviews were conducted to assess mammogram reports and method of detection. All clinical-pathologic and outcome parameters were analyzed to detect differences between the two cohorts. Results: Median follow-up was 7 years. There were no differences in final margins, T stage, nodal status, estrogen/progesterone receptor status, or 'triple-negative' status. Significant differences included younger age at diagnosis (p o histology (p < 0.0001). At 10 years, the differences in overall survival, cause-specific survival, and distant relapse between the two groups did not differ significantly. The MamOcc cohort had more breast relapses (15% vs. 8%; p = 0.0357), but on multivariate analysis this difference was not significant (hazard ratio 1.0, 95% confidence interval 0.993-1.007, p = 0.9296). Breast relapses were mammographically occult in 32% of the MamOcc and 12% of the MamPos cohorts (p = 0.0136). Conclusions: Although our study suggests that there are clinical-pathologic variations for the MamOcc cohort vs. MamPos patients that may ultimately affect management, breast relapse after BCT was not significantly different. Breast recurrences were more often mammographically occult in the MamOcc cohort; consideration should be given to closer follow-up and alternative imaging strategies (ultrasound, breast MRI) for routine posttreatment examination. To our knowledge, this represents the largest series addressing the prognostic significance of MamOcc cancers treated with BCT.

  4. The effect of solar radio bursts on the GNSS radio occultation signals

    Science.gov (United States)

    Yue, Xinan; Schreiner, William S.; Kuo, Ying-Hwa; Zhao, Biqiang; Wan, Weixing; Ren, Zhipeng; Liu, Libo; Wei, Yong; Lei, Jiuhou; Solomon, Stan; Rocken, Christian

    2013-09-01

    radio burst (SRB) is the radio wave emission after a solar flare, covering a broad frequency range, originated from the Sun's atmosphere. During the SRB occurrence, some specific frequency radio wave could interfere with the Global Navigation Satellite System (GNSS) signals and therefore disturb the received signals. In this study, the low Earth orbit- (LEO-) based high-resolution GNSS radio occultation (RO) signals from multiple satellites (COSMIC, CHAMP, GRACE, SAC-C, Metop-A, and TerraSAR-X) processed in University Corporation for Atmospheric Research (UCAR) were first used to evaluate the effect of SRB on the RO technique. The radio solar telescope network (RSTN) observed radio flux was used to represent SRB occurrence. An extreme case during 6 December 2006 and statistical analysis during April 2006 to September 2012 were studied. The LEO RO signals show frequent loss of lock (LOL), simultaneous decrease on L1 and L2 signal-to-noise ratio (SNR) globally during daytime, small-scale perturbations of SNR, and decreased successful retrieval percentage (SRP) for both ionospheric and atmospheric occultations during SRB occurrence. A potential harmonic band interference was identified. Either decreased data volume or data quality will influence weather prediction, climate study, and space weather monitoring by using RO data during SRB time. Statistically, the SRP of ionospheric and atmospheric occultation retrieval shows ~4% and ~13% decrease, respectively, while the SNR of L1 and L2 show ~5.7% and ~11.7% decrease, respectively. A threshold value of ~1807 SFU of 1415 MHz frequency, which can result in observable GNSS SNR decrease, was derived based on our statistical analysis.

  5. Ionospheric Remote Sensing using GPS Radio Occultation and Ultraviolet Photometry aboard the ISS

    Science.gov (United States)

    Budzien, S. A.; Powell, S. P.; O'Hanlon, B.; Humphreys, T.; Bishop, R. L.; Stephan, A. W.; Gross, J.; Chakrabarti, S.

    2017-12-01

    The GPS Radio Occultation and Ultraviolet Photometer Co-located (GROUP-C) experiment launched to the International Space Station (ISS) on February 19, 2017 as part of the Space Test Program Houston #5 payload (STP-H5). After early orbit testing, GROUP-C began routine science operations in late April. GROUP-C includes a high-sensitivity far-ultraviolet photometer measuring horizontal nighttime ionospheric gradients and an advanced software-defined GPS receiver providing ionospheric electron density profiles, scintillation measurements, and lower atmosphere profiles. GROUP-C and a companion experiment, the Limb-Imaging Ionospheric and Thermospheric Extreme-Ultraviolet Spectrograph (LITES), offer a unique capability to study spatial and temporal variability of the thermosphere and ionosphere using multi-sensor approaches, including ionospheric tomography. Data are collected continuously across low- and mid-latitudes as the ISS orbit precesses through all local times every 60 days. The GROUP-C GPS sensor routinely collects dual-frequency GPS occultations, makes targeted raw signal captures of GPS and Galileo occultations, and includes multiple antennas to characterize multipath in the ISS environment. The UV photometer measures the 135.6 nm ionospheric recombination airglow emision along the nightside orbital track. We present the first analysis of ionospheric observations, discuss the challenges and opportunities of remote sensing from the ISS platform, and explore how these new data help address questions regarding the complex and dynamic features of the low and middle latitude ionosphere-thermosphere relevant to the upcoming GOLD and ICON missions.

  6. Detection of occult vertebral fractures by quantitative assessment of bone marrow attenuation values at MDCT

    International Nuclear Information System (INIS)

    Henes, Frank Oliver; Groth, Michael; Kramer, Harald; Schaefer, Christian; Regier, Marc; Derlin, Thorsten; Adam, Gerhard; Bannas, Peter

    2014-01-01

    Objectives: To determine a cut-off value of Hounsfield attenuation units (HU) at multidetector computed tomography (MDCT) for valid and reliable detection of bone marrow oedema (BME) related to occult vertebral fractures. Methods: 36 patients underwent both MDCT and Magnetic Resonance Imaging (MRI) for evaluation of vertebral fractures of the thoracolumbar spine and were included in this retrospective study. Two readers independently assessed HU values at MDCT in a total of 196 vertebrae. Reliability was assessed by intraclass correlation coefficient and Bland–Altman analysis. For each patient we determined the vertebra with the lowest HU value and calculated the HU-difference to each other vertebral body. HU-differences were subjected to receiver operating characteristic (ROC) curve analysis to determine the diagnostic accuracy for detection of BME as determined by MRI, which served as the reference standard. Results of HU-measurements were compared with standard visual evaluation of MDCT. Results: HU measurements demonstrated a high interrater reliability (ICC = 0.984). ROC curve analysis (AUC = 0.978) exhibited an ideal cut-off value of 29.6 HU for detection of BME associated with vertebral fractures with an accuracy of 97.4% as compared to 93.4% accuracy of visual evaluation. Particularly, HU-measurements increased the sensitivity for detection of vertebral fractures from 78.0% to 92.7% due to the detection of 7 of 9 occult fractures that were missed by visual evaluation alone. Conclusions: Assessing bone marrow density by HU measurements using the cut-off of 29.6 HU is a valid and reliable tool for detection of BME related to occult vertebral fractures in MDCT. The introduced technique may allow more accurate treatment decisions and may make further diagnostic work-up with MRI unnecessary

  7. Detection of occult vertebral fractures by quantitative assessment of bone marrow attenuation values at MDCT

    Energy Technology Data Exchange (ETDEWEB)

    Henes, Frank Oliver, E-mail: f.henes@uke.de [Department of Diagnostic and Interventional Radiology, Center for Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg (Germany); Groth, Michael [Department of Diagnostic and Interventional Neuroradiology, Center for Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg (Germany); Kramer, Harald [Department of Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistr. 15, 81377 Munich (Germany); Department of Radiology, University of Wisconsin – Madison, Clinical Science Center, 600 Highland Avenue, Madison, WI 53792 (United States); Schaefer, Christian [Department of Trauma-, Hand- and Reconstructive Surgery, Spine Center, Center for Surgical Sciences, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg (Germany); Regier, Marc; Derlin, Thorsten; Adam, Gerhard; Bannas, Peter [Department of Diagnostic and Interventional Radiology, Center for Radiology and Endoscopy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg (Germany)

    2014-01-15

    Objectives: To determine a cut-off value of Hounsfield attenuation units (HU) at multidetector computed tomography (MDCT) for valid and reliable detection of bone marrow oedema (BME) related to occult vertebral fractures. Methods: 36 patients underwent both MDCT and Magnetic Resonance Imaging (MRI) for evaluation of vertebral fractures of the thoracolumbar spine and were included in this retrospective study. Two readers independently assessed HU values at MDCT in a total of 196 vertebrae. Reliability was assessed by intraclass correlation coefficient and Bland–Altman analysis. For each patient we determined the vertebra with the lowest HU value and calculated the HU-difference to each other vertebral body. HU-differences were subjected to receiver operating characteristic (ROC) curve analysis to determine the diagnostic accuracy for detection of BME as determined by MRI, which served as the reference standard. Results of HU-measurements were compared with standard visual evaluation of MDCT. Results: HU measurements demonstrated a high interrater reliability (ICC = 0.984). ROC curve analysis (AUC = 0.978) exhibited an ideal cut-off value of 29.6 HU for detection of BME associated with vertebral fractures with an accuracy of 97.4% as compared to 93.4% accuracy of visual evaluation. Particularly, HU-measurements increased the sensitivity for detection of vertebral fractures from 78.0% to 92.7% due to the detection of 7 of 9 occult fractures that were missed by visual evaluation alone. Conclusions: Assessing bone marrow density by HU measurements using the cut-off of 29.6 HU is a valid and reliable tool for detection of BME related to occult vertebral fractures in MDCT. The introduced technique may allow more accurate treatment decisions and may make further diagnostic work-up with MRI unnecessary.

  8. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention

    Science.gov (United States)

    Liskay, R.Michael

    2014-01-01

    Although Apc mutation is widely considered an initiating event in colorectal cancer, little is known about the earliest stages of tumorigenesis following sporadic Apc loss. Therefore, we have utilized a novel mouse model that facilitates the sporadic inactivation of Apc via frameshift reversion of Cre in single, isolated cells and subsequently tracks the fates of Apc-deficient intestinal cells. Our results suggest that consistent with Apc being a ‘gatekeeper’, loss of Apc early in life during intestinal growth leads to adenomas or increased crypt fission, manifested by fields of mutant but otherwise normal-appearing crypts. In contrast, Apc loss occurring later in life has minimal consequences, with mutant crypts being less prone to either increased crypt fission or adenoma formation. Using the stem cell-specific Lgr5-CreER mouse, we generated different sized fields of Apc-deficient crypts via independent recombination events and found that field size correlates with progression to adenoma. To evaluate this early stage prior to adenoma formation as a therapeutic target, we examined the chemopreventive effects of sulindac on Apc-deficient occult crypt fission. We found that sulindac treatment started early in life inhibits the morphologically occult spread of Apc-deficient crypts and thus reduces adenoma numbers. Taken together these results suggest that: (i) earlier Apc loss promotes increased crypt fission, (ii) a field of Apc-deficient crypts, which can form via occult crypt fission or independent neighboring events, is an important intermediate between loss of Apc and adenoma formation and (iii) normal-appearing Apc-deficient crypts are potential unappreciated targets for cancer screening and chemoprevention. PMID:23996931

  9. Astr 101 Students' Attitudes Towards Essays On Transits, Eclipses And Occultations

    Science.gov (United States)

    D'Cruz, Noella L.

    2012-05-01

    Joliet Junior College, Joliet, IL offers a one semester introductory astronomy course each semester. We teach over 110 primarily non-science major students each semester. We use proven active learning strategies such lecture tutorials, think-pair-share questions and small group discussions to help these students develop and retain a good understanding of astrophysical concepts. Occasionally, we offer projects that allow students to explore course topics beyond the classroom. We hope that such projects will increase students' interest in astronomy. We also hope that these assignments will help students to improve their critical thinking and writing skills. In Spring 12, we are offering three short individual essay assignments in our face-to-face sections. The essays focus on transits, eclipses and occultations to highlight the 2012 transit of Venus. For the first essay, students will find images of transit and occultation events using the Astronomy Picture of the Day website and describe their chosen events. In addition, students will predict how variations in certain physical and orbital parameters would alter their particular events. The second essay involves transits, eclipses and occultations observed by spacecraft. Students will describe their transit event, their spacecraft's mission, orbital path, how the orbital path was achieved, etc. The third essay deals with transiting exoplanets. Students will choose at least two exoplanets from an exoplanet database, one of which has been discovered through the transit method. This essay will enable students to learn about detecting exoplanets and how they compare with our solar system. Details of the essay assignments and students' reactions to them will be presented at the meeting.

  10. Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features.

    Science.gov (United States)

    Shi, Bibo; Grimm, Lars J; Mazurowski, Maciej A; Baker, Jay A; Marks, Jeffrey R; King, Lorraine M; Maley, Carlo C; Hwang, E Shelley; Lo, Joseph Y

    2018-03-01

    The aim of this study was to determine whether deep features extracted from digital mammograms using a pretrained deep convolutional neural network are prognostic of occult invasive disease for patients with ductal carcinoma in situ (DCIS) on core needle biopsy. In this retrospective study, digital mammographic magnification views were collected for 99 subjects with DCIS at biopsy, 25 of which were subsequently upstaged to invasive cancer. A deep convolutional neural network model that was pretrained on nonmedical images (eg, animals, plants, instruments) was used as the feature extractor. Through a statistical pooling strategy, deep features were extracted at different levels of convolutional layers from the lesion areas, without sacrificing the original resolution or distorting the underlying topology. A multivariate classifier was then trained to predict which tumors contain occult invasive disease. This was compared with the performance of traditional "handcrafted" computer vision (CV) features previously developed specifically to assess mammographic calcifications. The generalization performance was assessed using Monte Carlo cross-validation and receiver operating characteristic curve analysis. Deep features were able to distinguish DCIS with occult invasion from pure DCIS, with an area under the receiver operating characteristic curve of 0.70 (95% confidence interval, 0.68-0.73). This performance was comparable with the handcrafted CV features (area under the curve = 0.68; 95% confidence interval, 0.66-0.71) that were designed with prior domain knowledge. Despite being pretrained on only nonmedical images, the deep features extracted from digital mammograms demonstrated comparable performance with handcrafted CV features for the challenging task of predicting DCIS upstaging. Copyright © 2017 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  11. The size, shape, density and ring of the dwarf planet Haumea from a stellar occultation.

    Science.gov (United States)

    Ortiz, J L; Santos-Sanz, P; Sicardy, B; Benedetti-Rossi, G; Bérard, D; Morales, N; Duffard, R; Braga-Ribas, F; Hopp, U; Ries, C; Nascimbeni, V; Marzari, F; Granata, V; Pál, A; Kiss, C; Pribulla, T; Komžík, R; Hornoch, K; Pravec, P; Bacci, P; Maestripieri, M; Nerli, L; Mazzei, L; Bachini, M; Martinelli, F; Succi, G; Ciabattari, F; Mikuz, H; Carbognani, A; Gaehrken, B; Mottola, S; Hellmich, S; Rommel, F L; Fernández-Valenzuela, E; Bagatin, A Campo; Cikota, S; Cikota, A; Lecacheux, J; Vieira-Martins, R; Camargo, J I B; Assafin, M; Colas, F; Behrend, R; Desmars, J; Meza, E; Alvarez-Candal, A; Beisker, W; Gomes-Junior, A R; Morgado, B E; Roques, F; Vachier, F; Berthier, J; Mueller, T G; Madiedo, J M; Unsalan, O; Sonbas, E; Karaman, N; Erece, O; Koseoglu, D T; Ozisik, T; Kalkan, S; Guney, Y; Niaei, M S; Satir, O; Yesilyaprak, C; Puskullu, C; Kabas, A; Demircan, O; Alikakos, J; Charmandaris, V; Leto, G; Ohlert, J; Christille, J M; Szakáts, R; Farkas, A Takácsné; Varga-Verebélyi, E; Marton, G; Marciniak, A; Bartczak, P; Santana-Ros, T; Butkiewicz-Bąk, M; Dudziński, G; Alí-Lagoa, V; Gazeas, K; Tzouganatos, L; Paschalis, N; Tsamis, V; Sánchez-Lavega, A; Pérez-Hoyos, S; Hueso, R; Guirado, J C; Peris, V; Iglesias-Marzoa, R

    2017-10-11

    Haumea-one of the four known trans-Neptunian dwarf planets-is a very elongated and rapidly rotating body. In contrast to other dwarf planets, its size, shape, albedo and density are not well constrained. The Centaur Chariklo was the first body other than a giant planet known to have a ring system, and the Centaur Chiron was later found to possess something similar to Chariklo's rings. Here we report observations from multiple Earth-based observatories of Haumea passing in front of a distant star (a multi-chord stellar occultation). Secondary events observed around the main body of Haumea are consistent with the presence of a ring with an opacity of 0.5, width of 70 kilometres and radius of about 2,287 kilometres. The ring is coplanar with both Haumea's equator and the orbit of its satellite Hi'iaka. The radius of the ring places it close to the 3:1 mean-motion resonance with Haumea's spin period-that is, Haumea rotates three times on its axis in the time that a ring particle completes one revolution. The occultation by the main body provides an instantaneous elliptical projected shape with axes of about 1,704 kilometres and 1,138 kilometres. Combined with rotational light curves, the occultation constrains the three-dimensional orientation of Haumea and its triaxial shape, which is inconsistent with a homogeneous body in hydrostatic equilibrium. Haumea's largest axis is at least 2,322 kilometres, larger than previously thought, implying an upper limit for its density of 1,885 kilograms per cubic metre and a geometric albedo of 0.51, both smaller than previous estimates. In addition, this estimate of the density of Haumea is closer to that of Pluto than are previous estimates, in line with expectations. No global nitrogen- or methane-dominated atmosphere was detected.

  12. Radioguided breast surgery for occult lesion localization – correlation between two methods

    Directory of Open Access Journals (Sweden)

    Gutfilen Bianca

    2008-08-01

    Full Text Available Abstract Background The detection of sub-clinical breast lesions has increased with screening mammography. Biopsy techniques can offer precision and agility in its execution, as well as patient comfort. This trial compares radioguided occult lesion localization (ROLL and wire-guided localization (WL of breast lesions. We investigate if a procedure at the ambulatorial level (ROLL could lead to a better aesthetic result and less postoperative pain. In addition, we intend to demonstrate the efficacy of radioguided localization and removal of occult breast lesions using radiopharmaceuticals injected directly into the lesions and correlate radiological and histopathological findings. Methods One hundred and twenty patients were randomized into two groups (59 WL and 61 ROLL. The patients were requested to score the cosmetic appearance of their breast after surgery, and a numerical rating scale was used to measure pain on the first postoperative day. Clearance margins were considered at ≥ 10 mm for invasive cancer, ≥ 5 mm for ductal carcinoma in situ, and ≥ 1 mm for benign disease. Patients were subsequently treated according to the definitive histological result. When appropriate, different statistical tests were used in order to test the significance between the two groups, considering a P value Results WL and ROLL located all the occult breast lesions successfully. In the ROLL group, the specimen volume was smaller and there were more cases with clear margins (P Conclusion ROLL is an effective method for the excision of non-palpable breast lesions. It enables more careful planning of the cutaneous incision, leading to better aesthetic results, less postoperative symptoms, and smaller volumes of excised tissue.

  13. The Transit Light Curve Project. VIII. Six Occultations of the Exoplanet TrES-3

    OpenAIRE

    Winn, Joshua N.; Holman, Matthew J.; Shporer, Avi; Fernandez, Jose; Mazeh, Tsevi; Latham, David W.; Charbonneau, David; Everett, Mark E.

    2008-01-01

    We present photometry of the exoplanet host star TrES-3 spanning six occultations (secondary eclipses) of its giant planet. No flux decrements were detected, leading to 99%-confidence upper limits on the planet-to-star flux ratio of 0.00024, 0.0005, and 0.00086 in the i, z, and R bands respectively. The corresponding upper limits on the planet's geometric albedo are 0.30, 0.62, and 1.07. The upper limit in the i band rules out the presence of highly reflective clouds, and is only a factor of ...

  14. Goethe’s theory of colors between the ancient philosophy, middle ages occultism and modern science

    Directory of Open Access Journals (Sweden)

    Victor Barsan

    2016-12-01

    Full Text Available Goethe’s rejection of Newton’s theory of colors is an interesting example of the vulnerability of the human mind—however brilliant it might be—to fanaticism. After an analysis of Goethe’s persistent fascination with magic and occultism, of his education, existential experiences, influences, and idiosyncrasies, the authors propose an original interpretation of his anti-Newtonian position. The relevance of Goethe’s Farbenlehre to physics and physiology, from the perspective of modern science, is discussed in detail.

  15. Investigation of particle sizes in Pluto's atmosphere from the 29 June 2015 occultation

    Science.gov (United States)

    Sickafoose, Amanda A.; Bosh, A. S.; Person, M. J.; Zuluaga, C. A.; Levine, S. E.; Pasachoff, J. M.; Babcock, B. A.; Dunham, E. W.; McLean, I.; Wolf, J.; Abe, F.; Bida, T. A.; Bright, L. P.; Brothers, T.; Christie, G.; Collins, P. L.; Durst, R. F.; Gilmore, A. C.; Hamilton, R.; Harris, H. C.; Johnson, C.; Kilmartin, P. M.; Kosiarek, M. R.; Leppik, K.; Logsdon, S.; Lucas, R.; Mathers, S.; Morley, C. J. K.; Natusch, T.; Nelson, P.; Ngan, H.; Pfüller, E.; de, H.-P.; Sallum, S.; Savage, M.; Seeger, C. H.; Siu, H.; Stockdale, C.; Suzuki, D.; Thanathibodee, T.; Tilleman, T.; Tristam, P. J.; Van Cleve, J.; Varughese, C.; Weisenbach, L. W.; Widen, E.; Wiedemann, M.

    2015-11-01

    The 29 June 2015 observations of a stellar occultation by Pluto, from SOFIA and ground-based sites in New Zealand, indicate that haze was present in the lower atmosphere (Bosh et al., this conference). Previously, slope changes in the occultation light curve profile of Pluto’s lower atmosphere have been attributed to haze, a steep thermal gradient, and/or a combination of the two. The most useful diagnostic for differentiating between these effects has been observing occultations over a range of wavelengths: haze scattering and absorption are functions of particle size and are wavelength dependent, whereas effects due to a temperature gradient should be largely independent of observational wavelength. The SOFIA and Mt. John data from this event exhibit obvious central flashes, from multiple telescopes observing over a range of wavelengths at each site (Person et al. and Pasachoff et al., this conference). SOFIA data include Red and Blue observations from the High-speed Imaging Photometer for Occultations (HIPO, at ~ 500 and 850 nm), First Light Infrared Test Camera (FLITECAM, at ~1800 nm), and the Focal Plan Imager (FPI+, at ~ 600 nm). Mt. John data include open filter, g', r', i', and near infrared. Here, we analyze the flux at the bottom of the light curves versus observed wavelength. We find that there is a distinct trend in flux versus wavelength, and we discuss applicable Mie scattering models for different particle size distributions and compositions (as were used to characterize haze in Pluto's lower atmosphere in Gulbis et al. 2015).SOFIA is jointly operated by the Universities Space Research Association, Inc. (USRA), under NASA contract NAS2-97001, and the Deutsches SOFIA Institut (DSI) under DLR contract 50 OK 0901 to the University of Stuttgart. Support for this work was provided by the National Research Foundation of South Africa, NASA SSO grants NNX15AJ82G (Lowell Observatory), PA NNX10AB27G (MIT), and PA NNX12AJ29G (Williams College), and the NASA

  16. Electron number density profiles derived from radio occultation on the CASSIOPE spacecraft

    DEFF Research Database (Denmark)

    Shume, E. B.; Vergados, P.; Komjathy, A.

    2017-01-01

    This paper presents electron number density profiles derived from high resolution Global Positioning System (GPS) radio occultation (RO) observations performed using the Enhanced Polar Outflow Probe (e-POP) payload on the high inclination CAScade, Smallsat and IOnospheric Polar Explorer (CASSIOPE...... good agreement with density profiles estimated from ionosonde data, measured over nearby stations to the latitude and longitude of the RO tangent points, (2) in good agreement with density profiles inferred from GPS RO measured by the Constellation Observing System for Meteorology, Ionosphere...

  17. Impact of GPS Radio Occultation Refractivity Soundings on a Simulation of Typhoon Bilis (2006 upon Landfall

    Directory of Open Access Journals (Sweden)

    Mien-Tze Kueh

    2009-01-01

    Full Text Available Typhoon Bilis which struck Taiwan in July 2006 was chosen to assess the potential impact of GPS radio occultation (RO refractivity soundings on numerical simulation using the WRF model. We found that this case elucidates the impact of the limited GPS RO soundings on typhoon prediction due to their favorable locations. In addition, on top of available precipitable water (PW and near-surface wind speed from SSM/I data, we have also explored their combined impacts on model prediction.

  18. GEROS-ISS: GNSS REflectometry, Radio Occultation and Scatterometry onboard the International Space Station

    DEFF Research Database (Denmark)

    Wickert, Jens; Cardellach, Estel; Bandeiras, Jorge

    2016-01-01

    GEROS-ISS stands for GNSS REflectometry, radio occultation, and scatterometry onboard the International Space Station (ISS). It is a scientific experiment, successfully proposed to the European Space Agency in 2011. The experiment as the name indicates will be conducted on the ISS. The main focus...... of GEROS-ISS is the dedicated use of signals from the currently available Global Navigation Satellite Systems (GNSS) in L-band for remote sensing of the Earth with a focus to study climate change. Prime mission objectives are the determination of the altimetric sea surface height of the oceans...

  19. Theory for the effects of turbulence in a planetary atmosphere on radio occultation

    Science.gov (United States)

    Woo, R.; Ishimaru, A.

    1974-01-01

    Rytov's method is used to formulate the correlation functions for log-amplitude and phase fluctuations for both spherical and plane wave propagation in a turbulent medium whose correlation function for refractive index fluctuations is described by the product of a function of the average coordinate and a function of the difference coordinate. The results are applied to the study of radio occultation effects due to the atmosphere of Venus in the case of a flyby space probe. It is assumed that turbulence of isotropic and smoothly varying characteristics occurs in the Venusian atmosphere.

  20. Sonographic swelling of pronator quadratus muscle in patients with occult bone injury

    International Nuclear Information System (INIS)

    Sato, Junko; Ishii, Yoshinori; Noguchi, Hideo; Toyabe, Shin-ichi

    2015-01-01

    The disarranged fat stripe of the pronator quadratus muscle (PQ) on radiographs (the PQ sign) is reported to be predictive of subtle bone fractures. This study aimed to report the results of magnetic resonance imaging (MRI) study in the patients in whom bone injury was not radiographically detected around the wrist joint, and the PQ was sonographically swollen following acute trauma. We evaluated sonographically the PQ of 55 patients who showed normal radiographs following acute trauma. The sonographic appearance of the PQ was checked on both longitudinal and transverse images. On the longitudinal image, the probe was positioned along the flexor carpi radialis tendon. For the transverse image, we adopted the image of the same level in which the PQ of the unaffected hand showed maximal thickness. The PQ was considered to be swollen with disproportionate hyperechogenicity and/or thickening compared with the unaffected side at least in one of the two images. Of the 55 patients, 25 patients whose PQ was considered to be swollen underwent MRI study. PQ thickness in millimeters was retrospectively measured on longitudinal and transverse sonographic images. Twenty-three patients (92.0%) had occult bone injury, and two adult patients (8.0%) showed only wrist joint effusion on MRI. Among these 23, the distal radius was the most frequent location of the occult bone injury (20 patients; 9 [36.0%] with an occult fracture line and 11 [44.0%] with bone bruising). In longitudinal image, the mean value of the PQ thickness of affected hands was 6.2 (3.7–9.6 mm; standard deviation [SD], 1.5) and that of unaffected hands was 4.5 (2.3–6.7 mm; SD, 1.2), respectively. In transverse image, that of dominant and nondominant hands was 7.6 (4.6–13.2 mm; SD, 2.0) and 5.5 (3.6–7.5 mm; SD, 1.1), respectively. The mean difference in PQ thickness between affected and unaffected hands was 1.7 (0.1–5.0 mm; SD, 1.1) in longitudinal image and 2.0 (0.3–6.8 mm; SD, 1.7) in transverse image

  1. Astrology and other occult sciences in seventeenth-century New Spain.

    Science.gov (United States)

    Avalos, Ana

    2006-01-01

    This article focuses on the relationship and mutual influence of astrology and other so-called occult sciences within the context of seventeenth-century New Spain. By presenting some case studies of inquisitorial trials against astrologers, it explores the interrelation between astrological and physiognomical ideas and practices in order to shed some light on the moral dimension of these natural philosophical fields of knowledge. During the early modern period, both astrology and physiognomy were regarded as tools for self-understanding and the understanding of others by means of interpretation of natural signs. Thus their history is key for understanding the shaping of the boundaries between the natural and the moral realms.

  2. Determinants of participation in colorectal cancer screening with faecal occult blood testing

    DEFF Research Database (Denmark)

    von Euler-Chelpin, My; Brasso, Klaus; Lynge, Elsebeth

    2009-01-01

    BACKGROUND: Colorectal cancer is one of the most common cancers in men and women. Participation rates in faecal occult blood testing (FOBT) screening activities are, however, relatively low. In terms of lowering the colorectal cancer mortality, high participation rates are essential, and therefore......, but determinants varied across countries and test settings. There was no systematic variation in participation across age groups. CONCLUSION: The participation pattern depends in part on local circumstances, which makes it difficult to point to a general strategy for increasing the uptake in FOBT screening...

  3. Unusual Case of Occult Brucella Osteomyelitis in the Skull Detected by Bone Scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Sohn, Myung Hee; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Lee, Chang Seob [Chonbuk National University Medical School, Jeonju (Korea, Republic of)

    2010-06-15

    Brucellosis is a worldwide infectious disease of animals that can be transmitted to humans. Osteoarticular involvement is the most common complication of brucellosis. A 47-year-old man, who was a stock breeder, complained of myalgia with fever and chills for 2 weeks. The serology titers and blood cultures for brucellosis were positive. Bone scintigraphy demonstrated a focally increased uptake in the left supra orbital area. Plain radiographs showed an osteolytic lesion, and an MRI revealed signal abnormalities in the corresponding site. We present an unusual case of occult Brucella osteomyelitis in the frontal bone of the skull detected by done scintigraphy.

  4. THE 2011 JUNE 23 STELLAR OCCULTATION BY PLUTO: AIRBORNE AND GROUND OBSERVATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Person, M. J.; Bosh, A. S.; Levine, S. E.; Gulbis, A. A. S.; Zangari, A. M.; Zuluaga, C. A.; Sallum, S. [Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139-4307 (United States); Dunham, E. W.; Collins, P.; Bida, T.; Bright, L. [Lowell Observatory, Flagstaff, AZ (United States); Pasachoff, J. M.; Babcock, B. A.; Pandey, S.; Amrhein, D. [Williams College-Hopkins Observatory, Williamstown, MA (United States); Tholen, D. J. [Institute for Astronomy, University of Hawaii, Manoa, HI (United States); Taylor, B. [Boston University, Boston, MA (United States); Wolf, J.; Pfueller, E. [Deutsches SOFIA Institut, Universitaet Stuttgart, Pfaffenwaldring 29, D-70569 Stuttgart (Germany); Meyer, A., E-mail: mjperson@mit.edu [SOFIA Science Center, NASA Ames Research Center, MS 211-1, Moffett Field, CA 94035 (United States); and others

    2013-10-01

    On 2011 June 23, stellar occultations by both Pluto (this work) and Charon (future analysis) were observed from numerous ground stations as well as the Stratospheric Observatory for Infrared Astronomy (SOFIA). This first airborne occultation observation since 1995 with the Kuiper Airborne Observatory resulted in the best occultation chords recorded for the event, in three visible wavelength bands. The data obtained from SOFIA are combined with chords obtained from the ground at the IRTF, the U.S. Naval Observatory Flagstaff Station, and Leeward Community College to give the detailed state of the Pluto-Charon system at the time of the event with a focus on Pluto's atmosphere. The data show a return to the distinct upper and lower atmospheric regions with a knee or kink in the light curve separating them as was observed in 1988, rather than the smoothly transitioning bowl-shaped light curves of recent years. The upper atmosphere is analyzed by fitting a model to all of the light curves, resulting in a half-light radius of 1288 {+-} 1 km. The lower atmosphere is analyzed using two different methods to provide results under the differing assumptions of particulate haze and a strong thermal gradient as causes for the lower atmospheric diminution of flux. These results are compared with those from past occultations to provide a picture of Pluto's evolving atmosphere. Regardless of which lower atmospheric structure is assumed, results indicate that this part of the atmosphere evolves on short timescales with results changing the light curve structures between 1988 and 2006, and then reverting these changes in 2011 though at significantly higher pressures. Throughout these changes, the upper atmosphere remains remarkably stable in structure, again except for the overall pressure changes. No evidence of onset of atmospheric collapse predicted by frost migration models is seen, and the atmosphere appears to be remaining at a stable pressure level, suggesting it

  5. A unique airborne observation. [Martian atmospheric temperature and abundances from occultation of Epsilon Geminorum

    Science.gov (United States)

    Elliot, J. L.; Dunham, E.; Church, C.

    1976-01-01

    The occultation of 3rd magnitude Epsilon Geminorum by Mars was observed using a 36-inch telescope equipped with a photoelectric photometer at the bent Cassegrain focus, carried aboard the Kuiper Airborne Observatory at altitudes up to 45,000 feet. Scintillation from the earth's atmosphere was greatly reduced in comparison with ground observations. The observations clearly show the central flash, caused by the symmetrical refraction of light by the atmosphere of Mars. The data are being analyzed to obtain temperature profiles and to assess the relative abundance of argon and carbon dioxide in the atmosphere of the planet.

  6. Spatial irregularities in Jupiter's upper ionosphere observed by Voyager radio occultations

    Science.gov (United States)

    Hinson, D. P.; Tyler, G. L.

    1982-01-01

    Radio scintillations (at 3.6 and 13 cm) produced by scattering from ionospheric irregularities during the Voyager occultations are interpreted using a weak-scattering theory. Least squares solutions for ionospheric parameters derived from the observed fluctuation spectra yield estimates of (1) the axial ratio, (2) angular orientation of the anisotropic irregularities, (3) the power law exponent of the spatial spectrum of irregularities, and (4) the magnitude of the spatial variations in electron density. It is shown that the measured angular orientation of the anisotropic irregularities indicates magnetic field direction and may provide a basis for refining Jovian magnetic field models.

  7. COSMIC Radio Occultation technique for measurement of the tropopause during tropical cyclones

    DEFF Research Database (Denmark)

    Biondi, Riccardo; Neubert, Torsten; Syndergaard, Stig

    Basin during July 2008 and reached a maximum intensity of Category 3 and the typhoon Hondo, formed in the south Indian basin during February 2008 with maximum intensity of Category 4. Using measurements from a variety of earth observation satellites (A-Train constellation) and from aircraft together...... and they cool the tropopause layers. The GPS radio occultation technique is useful for studying severe weather phenomena because the GPS signals penetrate through clouds and allow measurements of atmospheric profiles related to temperature, pressure, and water vapour with high vertical resolution...

  8. Unusual Case of Occult Brucella Osteomyelitis in the Skull Detected by Bone Scintigraphy

    International Nuclear Information System (INIS)

    Sohn, Myung Hee; Lim, Seok Tae; Jeong, Young Jin; Kim, Dong Wook; Jeong, Hwan Jeong; Lee, Chang Seob

    2010-01-01

    Brucellosis is a worldwide infectious disease of animals that can be transmitted to humans. Osteoarticular involvement is the most common complication of brucellosis. A 47-year-old man, who was a stock breeder, complained of myalgia with fever and chills for 2 weeks. The serology titers and blood cultures for brucellosis were positive. Bone scintigraphy demonstrated a focally increased uptake in the left supra orbital area. Plain radiographs showed an osteolytic lesion, and an MRI revealed signal abnormalities in the corresponding site. We present an unusual case of occult Brucella osteomyelitis in the frontal bone of the skull detected by done scintigraphy.

  9. Unmasking of a hemizygous WFS1 gene mutation by a chromosome 4p deletion of 8.3 Mb in a patient with Wolf-Hirschhorn syndrome.

    Science.gov (United States)

    Flipsen-ten Berg, Klara; van Hasselt, Peter M; Eleveld, Marc J; van der Wijst, Suzanne E; Hol, Frans A; de Vroede, Monique A M; Beemer, Frits A; Hochstenbach, P F Ron; Poot, Martin

    2007-11-01

    The Wolf-Hirschhorn syndrome (WHS (MIM 194190)), which is characterized by growth delay, mental retardation, epilepsy, facial dysmorphisms, and midline fusion defects, shows extensive phenotypic variability. Several of the proposed mutational and epigenetic mechanisms in this and other chromosomal deletion syndromes fail to explain the observed phenotypic variability. To explain the complex phenotype of a patient with WHS and features reminiscent of Wolfram syndrome (WFS (MIM 222300)), we performed extensive clinical evaluation and classical and molecular cytogenetic (GTG banding, FISH and array-CGH) and WFS1 gene mutation analyses. We detected an 8.3 Mb terminal deletion and an adjacent 2.6 Mb inverted duplication in the short arm of chromosome 4, which encompasses a gene associated with WFS (WFS1). In addition, a nonsense mutation in exon 8 of the WFS1 gene was found on the structurally normal chromosome 4. The combination of the 4p deletion with the WFS1 point mutation explains the complex phenotype presented by our patient. This case further illustrates that unmasking of hemizygous recessive mutations by chromosomal deletions represents an additional explanation for the phenotypic variability observed in chromosomal deletion disorders.

  10. Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis.

    Science.gov (United States)

    Chen, Jiafeng; Zhu, Lijun; Li, He; Lu, Ziwen; Chen, Xin; Fang, Shaokuan

    2016-10-01

    Multiple sclerosis (MS) is easily detected by routine magnetic resonance imaging (MRI). However, it is not possible to detect early or occult lesions in MS by routine MRI, and this may explain the inconsistency between the severity of the lesions found by MRI and the degree of clinical disability of patients with MS. The present study included 10 patients with relapsing-remitting MS and 10 healthy volunteers. Each patient underwent routine 3.0 T MRI, diffusion tensor imaging (DTI), and diffusion tensor tractography (DTT). Optic nerve and optic radiation were analyzed by DTI and DTT. The fractional anisotropy (FA), mean diffusivity (MD), λ // , and λ ┴ values were measured. In the 10 patients with MS, 7 optic nerves were affected, and 13 optic nerves were not affected. Cranial MRI showed that optic nerve thickening and hyperintensity occurred in 2 patients with MS. In the directionally encoded color maps, a hypointensive green signal in the optic nerve was observed in 3 patients with MS. The FA values were significantly lower and the MD, λ // , and λ ┴ values were significantly higher in the affected and unaffected optic nerves and optic radiations in patients with MS in comparison with controls (P0.05). Diffusion tensor imaging is sensitive in the detection of occult injury of the optic nerve and optic radiation following optic neuritis. Diffusion tensor imaging may be a useful tool for the early diagnosis, treatment and management of MS.

  11. When the bell tolls on Bell's palsy: finding occult malignancy in acute-onset facial paralysis.

    Science.gov (United States)

    Quesnel, Alicia M; Lindsay, Robin W; Hadlock, Tessa A

    2010-01-01

    This study reports 4 cases of occult parotid malignancy presenting with sudden-onset facial paralysis to demonstrate that failure to regain tone 6 months after onset distinguishes these patients from Bell's palsy patients with delayed recovery and to propose a diagnostic algorithm for this subset of patients. A case series of 4 patients with occult parotid malignancies presenting with acute-onset unilateral facial paralysis is reported. Initial imaging on all 4 patients did not demonstrate a parotid mass. Diagnostic delays ranged from 7 to 36 months from time of onset of facial paralysis to time of diagnosis of parotid malignancy. Additional physical examination findings, especially failure to regain tone, as well as properly protocolled radiologic studies reviewed with dedicated head and neck radiologists, were helpful in arriving at the diagnosis. An algorithm to minimize diagnostic delays in this subset of acute facial paralysis patients is presented. Careful attention to facial tone, in addition to movement, is important in the diagnostic evaluation of acute-onset facial paralysis. Copyright 2010 Elsevier Inc. All rights reserved.

  12. [Identification of occult disseminated tumor cells by recombinant herpes simplex virus expressing GFP (HSV(GFP))].

    Science.gov (United States)

    Han, Xiang-ping; Shi, Gui-lan; Wang, Cheng-feng; Li, Jie; Zhang, Jian-wei; Zhang, Yu; Zhang, Shu-ren; Liu, Bin-lei

    2012-12-01

    To develop a novel rapid protocol for the detection of occult disseminated tumor cells by a recombinant herpes simplex virus expressing GFP (HSV(GFP)). Tumor cells of seven cell lines were exposed to HSV(GFP) and then examined for GFP expression by fluorescence microscopy. Various numbers of tumor cells (10, 100, 1000, 10 000) were mixed into 2 ml human whole blood, separated with lymphocytes separation medium, exposed to HSV(GFP), incubated at 37°C for 6 - 24 h and then counted for the number of green cells under the fluorescence microscope. Some clinical samples including peripheral blood, pleural effusion, ascites, spinal fluid from tumor-bearing patients were screened using this protocol in parallel with routine cytological examination. HSV(GFP) was able to infect all 7 tumor cell lines indicating that the HSV(GFP) can be used to detect different types of tumor cells. The detection sensitivity was 10 cancer cells in 2 ml whole blood. In the clinical samples, there were 4/15 positive by routine cytological examination but 11/15 positive by HSV(GFP), indicating a higher sensitivity of this new protocol. Recombinant herpes simplex virus-mediated green fluorescence is a simple and sensitive technique for the identification of occult disseminated cancer cells including circulating tumor cells (CTCs).

  13. DM ORI: A YOUNG STAR OCCULTED BY A DISTURBANCE IN ITS PROTOPLANETARY DISK

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, Joseph E.; Stassun, Keivan G.; Lund, Michael B.; Weintraub, David A. [Department of Physics and Astronomy, Vanderbilt University, 6301 Stevenson Center, Nashville, TN 37235 (United States); Cargile, Phillip [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Shappee, Benjamin J. [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Siverd, Robert J. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Pepper, Joshua [Department of Physics, Lehigh University, 16 Memorial Drive East, Bethlehem, PA 18015 (United States); Kochanek, Christopher S.; Gaudi, B. Scott; Stanek, Krzysztof Z.; Holoien, Thomas W.-S. [Department of Astronomy, The Ohio State University, Columbus, OH 43210 (United States); James, David [Cerro Tololo InterAmerican Observatory, Casilla 603, La Serena (Chile); Kuhn, Rudolf B. [South African Astronomical Observatory, P.O. Box 9, Observatory 7935 (South Africa); Beatty, Thomas G. [Department of Astronomy and Astrophysics, The Pennsylvania State University, 525 Davey Lab, University Park, PA 16802 (United States); Prieto, Jose L. [Nucleo de Astronoma de la Facultad de Ingeniera, Universidad Diego Portales, Av. Ejercito 441, Santiago (Chile); Feldman, Daniel M.; Espaillat, Catherine C. [Department of Astronomy, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States)

    2016-11-01

    In some planet formation theories, protoplanets grow gravitationally within a young star’s protoplanetary disk, a signature of which may be a localized disturbance in the disk’s radial and/or vertical structure. Using time-series photometric observations by the Kilodegree Extremely Little Telescope South project and the All-Sky Automated Survey for SuperNovae, combined with archival observations, we present the discovery of two extended dimming events of the young star, DM Ori. This young system faded by ∼1.5 mag from 2000 March to 2002 August and then again in 2013 January until 2014 September (depth ∼1.7 mag). We constrain the duration of the 2000–2002 dimming to be < 860 days, and the event in 2013–2014 to be < 585 days, separated by ∼12.5 years. A model of the spectral energy distribution indicates a large infrared excess consistent with an extensive circumstellar disk. Using basic kinematic arguments, we propose that DM Ori is likely being periodically occulted by a feature (possibly a warp or perturbation) in its circumstellar disk. In this scenario, the occulting feature is located >6 au from the host star, moving at ∼14.6 km s{sup −1} and is ∼4.9 au in width. This localized structure may indicate a disturbance such as that which may be caused by a protoplanet early in its formation.

  14. Evaluation of Refractivity Profiles from CHAMP and SAC-C GPS Radio Occultation

    Science.gov (United States)

    Poli, Paul; Ao, Chi On; Joiner, Joanna; delaTorreJuarez, Manuel; Hoff, Raymond

    2002-01-01

    The GeoForschungsZentrum's Challenging Minisatellite Payload for Geophysical Research and Application (CHAMP, Germany-US) and the Comision Nacional de Actividades Especiales' Satelite de Aplicaciones Cientificas-C (SAC-C, Argentina-US) missions are the first missions to carry a second-generation Blackjack Global Positioning System (GPS) receiver. One of the new features of this receiver is its ability to sense the lower troposphere closer to the surface than the proof-of-concept GPS Meteorology experiment (GPS/MET). Since their launch, CHAMP and SAC-C have collected thousands of GPS radio occultations, representing a wealth of measurements available for data assimilation and Numerical Weather Prediction (NWP). In order to evaluate the refractivity data derived by the Jet Propulsion Laboratory (JPL) from raw radio occultation measurements, we use Data Assimilation Office (DAO) 6-hour forecasts as an independent state of the atmosphere. We compare CHAMP and SAC-C refractivity (processed by JPL) with refractivity calculated from the DAO global fields of temperature, water vapor content and humidity. We show statistics of the differences as well as histograms of the differences.

  15. Taiwan/TriG Radio Occultation Process System (TROPS): A Brief Introduction of Atmospheric Productions

    Science.gov (United States)

    Huang, Cheng-Yung; Yeh, Wen-Hao; Tseng, Tzu-Pang; Chen, Linton J.

    2017-04-01

    Global Positioning System (GPS) Radio Occultation (RO) technique has been used to investigate the Earth's atmosphere since 1990s. In 2006, Taiwan has launched six low Earth orbit (LEO) satellites as a RO constellation mission, named FORMOSAT-3 /COSMIC (F-3/C). F-3/C mission can release 1500-2500 data sets per day for both neutral atmosphere and ionosphere. With the advent of Global Navigation Satellite System (GNSS) in ten years and FORMOSAT-7/COSMIC-2 (F-7/C-2) mission, 12 LEO satellites are planned to be launched and deployed in two clusters of 6-satellites into the designated low and high inclination orbits in 2017 and 2020(TBD), respectively. The amount of RO data set will increase to about 8000 set per day with the using of GNSS TriG (GPS, Glonass, Galileo) receivers. The first phase of FS-7 mission is designed to low inclination (24 deg) orbit to improve the ability of server weather forecasting, like typhoon and monsoon rainfall around tropical region. The second is high inclination (72 deg) for global distribution. In order to observe better water vapor profiles, the 4x3 antennas arrays will be on board to receive weak signals which pass through low troposphere around earth surface. This report will introduce the status of F-7/C-2 mission and atmospheric part of occultation data process software TROPS.

  16. Wavelength dependence of the effects of turbulence on average refraction angles in occultations by planetary atmospheres

    International Nuclear Information System (INIS)

    Haugstad, B.S.; Eshleman, V.R.

    1979-01-01

    Two recent adjacently published papers on the average effects of turbulence in radio and optical occultation studies of planetary atmospheres appear to disagree on the question of wavelength dependence. It is demonstrated here that in deriving a necessary condition for the applicability of their method. Hubbard and Jokipii neglect a factor which is proportional to the square of the ratio of the atmospheric or local Fresnel zone radius and the inner scale of turbulence. They also fail to establish sufficient conditions, thereby omitting as a further factor the square of the ratio of atmospheric scale height and the local Fresnel zone radius. The total descrepancy, which numerically is typically within several orders of magnitude of 10 11 for radio and 10 7 for optical occultations, means that their results correspond to geometrical optics and not to wave optics as claimed. Thus their results are inherently inapplicable in a discussion of the wavelength dependence of any parameter, such as the bias in the average refraction angle treated by Eshleman and Haugstad. We note that for power spectra characterized by the (--p) exponent of the turbulence wavenumber, the average turbulence-induced bias in refraction angles depends on the radiation wavelength as lambda/sup( p/--4)/2, or as lambda/sup en-dash1/6/ for Kolmogorov turbulence. Other features of the Hubbard-Jokipii analysis are also discussed

  17. A modification to the standard ionospheric correction method used in GPS radio occultation

    Directory of Open Access Journals (Sweden)

    S. B. Healy

    2015-08-01

    Full Text Available A modification to the standard bending-angle correction used in GPS radio occultation (GPS-RO is proposed. The modified approach should reduce systematic residual ionospheric errors in GPS radio occultation climatologies. A new second-order term is introduced in order to account for a known source of systematic error, which is generally neglected. The new term has the form κ(a × (αL1(a-αL2(a2, where a is the impact parameter and (αL1, αL2 are the L1 and L2 bending angles, respectively. The variable κ is a weak function of the impact parameter, a, but it does depend on a priori ionospheric information. The theoretical basis of the new term is examined. The sensitivity of κ to the assumed ionospheric parameters is investigated in one-dimensional simulations, and it is shown that κ ≃ 10–20 rad−1. We note that the current implicit assumption is κ=0, and this is probably adequate for numerical weather prediction applications. However, the uncertainty in κ should be included in the uncertainty estimates for the geophysical climatologies produced from GPS-RO measurements. The limitations of the new ionospheric correction when applied to CHAMP (Challenging Minisatellite Payload measurements are noted. These arise because of the assumption that the refractive index is unity at the satellite, made when deriving bending angles from the Doppler shift values.

  18. Hard X-Ray Emission from Partially Occulted Solar Flares: RHESSI Observations in Two Solar Cycles

    Energy Technology Data Exchange (ETDEWEB)

    Effenberger, Frederic; Costa, Fatima Rubio da; Petrosian, Vahé [Department of Physics and KIPAC, Stanford University, Stanford, CA 94305 (United States); Oka, Mitsuo; Saint-Hilaire, Pascal; Krucker, Säm [Space Sciences Laboratory, University of California, Berkeley, CA 94720-7450 (United States); Liu, Wei [Bay Area Environmental Research Institute, 625 2nd Street, Suite 209, Petaluma, CA 94952 (United States); Glesener, Lindsay, E-mail: feffen@stanford.edu, E-mail: frubio@stanford.edu [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States)

    2017-02-01

    Flares close to the solar limb, where the footpoints are occulted, can reveal the spectrum and structure of the coronal looptop source in X-rays. We aim at studying the properties of the corresponding energetic electrons near their acceleration site, without footpoint contamination. To this end, a statistical study of partially occulted flares observed with Reuven Ramaty High-Energy Solar Spectroscopic Imager is presented here, covering a large part of solar cycles 23 and 24. We perform detailed spectra, imaging, and light curve analyses for 116 flares and include contextual observations from SDO and STEREO when available, providing further insights into flare emission that were previously not accessible. We find that most spectra are fitted well with a thermal component plus a broken power-law, non-thermal component. A thin-target kappa distribution model gives satisfactory fits after the addition of a thermal component. X-ray imaging reveals small spatial separation between the thermal and non-thermal components, except for a few flares with a richer coronal source structure. A comprehensive light curve analysis shows a very good correlation between the derivative of the soft X-ray flux (from GOES ) and the hard X-rays for a substantial number of flares, indicative of the Neupert effect. The results confirm that non-thermal particles are accelerated in the corona and estimated timescales support the validity of a thin-target scenario with similar magnitudes of thermal and non-thermal energy fluxes.

  19. ULTRA-WIDE-FIELD FUNDUS AUTOFLUORESCENCE FINDINGS IN PATIENTS WITH ACUTE ZONAL OCCULT OUTER RETINOPATHY.

    Science.gov (United States)

    Shifera, Amde Selassie; Pennesi, Mark E; Yang, Paul; Lin, Phoebe

    2017-06-01

    To determine whether ultra-wide-field fundus autofluorescence (UWFFAF) findings in acute zonal occult outer retinopathy correlated well with perimetry, optical coherence tomography, and electroretinography findings. Retrospective observational study on 16 eyes of 10 subjects with AZOOR seen at a single referral center from October 2012 to March 2015 who had UWFFAF performed. Chi-square analysis was performed to compare categorical variables, and Mann-Whitney U test used for comparisons of nonparametric continuous variables. All eyes examined within 3 months of symptom onset (five of the five eyes) had diffusely hyperautofluorescent areas on UWFFAF. The remaining eyes contained hypoautofluorescent lesions with hyperautofluorescent borders. In 11/16 (68.8%) eyes, UWFFAF showed the full extent of lesions that would not have been possible with standard fundus autofluorescence centered on the fovea. There were 3 patterns of spread: centrifugal spread (7/16, 43.8%), centripetal spread (5/16, 31.3%), and centrifugal + centripetal spread (4/16, 25.0%). The UWFFAF lesions corresponded well with perimetric, optical coherence tomography, and electroretinography abnormalities. The UWFFAF along with optical coherence tomography can be useful in the evaluation and monitoring of acute zonal occult outer retinopathy patients.

  20. Atmospheric Drag, Occultation ‘N’ Ionospheric Scintillation (ADONIS mission proposal

    Directory of Open Access Journals (Sweden)

    Hettrich Sebastian

    2015-01-01

    Full Text Available The Atmospheric Drag, Occultation ‘N’ Ionospheric Scintillation mission (ADONIS studies the dynamics of the terrestrial thermosphere and ionosphere in dependency of solar events over a full solar cycle in Low Earth Orbit (LEO. The objectives are to investigate satellite drag with in-situ measurements and the ionospheric electron density profiles with radio occultation and scintillation measurements. A constellation of two satellites provides the possibility to gain near real-time data (NRT about ionospheric conditions over the Arctic region where current coverage is insufficient. The mission shall also provide global high-resolution data to improve assimilative ionospheric models. The low-cost constellation can be launched using a single Vega rocket and most of the instruments are already space-proven allowing for rapid development and good reliability. From July 16 to 25, 2013, the Alpbach Summer School 2013 was organised by the Austrian Research Promotion Agency (FFG, the European Space Agency (ESA, the International Space Science Institute (ISSI and the association of Austrian space industries Austrospace in Alpbach, Austria. During the workshop, four teams of 15 students each independently developed four different space mission proposals on the topic of “Space Weather: Science, Missions and Systems”, supported by a team of tutors. The present work is based on the mission proposal that resulted from one of these teams’ efforts.

  1. Overt and occult vidian canal involvement in juvenile angiofibroma and its possible impact on recurrence.

    Science.gov (United States)

    Thakar, Alok; Hota, Ashutosh; Bhalla, Ashu Seth; Gupta, Siddharth Datta; Sarkar, Chitra; Kumar, Rakesh

    2016-04-01

    Postexcision residual disease in the vidian canal is speculated to contribute to recurrence in juvenile angiofibroma. We composed a prospective cohort of 16 consecutive patients with juvenile angiofibroma (stages IIA-IIIB). The presurgical vidian canal assessment was done by contrast-enhanced CT (1.2 mm collimation). At surgery after complete tumor excision, the vidian canal tissue was sampled for histology. Postexcision drilling of the vidian canal was done in 8 of 15 patients to remove microscopic residual disease, with a 24 to 48 month follow-up period. Presurgical radiology indicated ipsilateral vidian canal enlargement (≥3 mm)/destruction in 13 of 16 patients. Radiologically occult involvement was documented only by histology in another 1 of 16 patients. Postexcision sampling of the vidian canal noted microscopic residual tumor in 3 of 15 patients. No recurrences were noted in 8 cases (0 of 8) with postexcision drilling of the vidian canal and 2 recurrences in 7 cases (2 of 7) with no drilling (p = .20). Vidian canal involvement in juvenile angiofibroma is almost universal (14 of 16) and may be occult to CT evaluation. The site may harbor microscopic residual tumor after seemingly complete excision. Surgical attention toward it may reduce recurrences. © 2015 Wiley Periodicals, Inc. Head Neck 38: E421-425, 2016. © 2015 Wiley Periodicals, Inc.

  2. Inverted Meckel's diverticulum as a cause of occult lower gastrointestinal hemorrhage

    Institute of Scientific and Technical Information of China (English)

    Omar M Rashid; Joseph K Ku; Masayuki Nagahashi; Akimitsu Yamada; Kazuaki Takabe

    2012-01-01

    Meckel's diverticulum is a common asymptomatic congenital gastrointestinal anomaly,but rarely it can present with hemorrhage.Over the last few years inverted Meckel's diverticulum has been reported in the literature with increasing frequency as an occult source of lower gastrointestinal hemorrhage.Here,we report a case of a 54-year-old male,who was referred for surgical evaluation with persistent anemia and occult blood per rectum after a work up which failed to localize the source over 12 mo,including upper and capsule endoscopy,colonoscopy,enteroclysis,Meckel scan,and tagged nuclear red blood cell scan.An abdominal computed tomography scan showed a possible mid-ileal intussusception and intraluminal mass.During the abdominal exploration,inverted Meckel's diverticulum was diagnosed and resected.We review the literature,discuss the forms in which the disease presents,the diagnostic modalities utilized,pathological findings,and treatment.Although less than 40 cases have been reported in the English literature from 1978 to 2005,19 cases have been reported in the last 6 years alone (2006-2012) due to improved diagnostic modalities.Successful diagnosis and treatment of this disease requires a high index of clinical suspicion,which is becoming increasingly relevant to general gastroenterologists.

  3. Final binary star results from the ESO VLT Lunar occultations program

    Energy Technology Data Exchange (ETDEWEB)

    Richichi, A. [National Astronomical Research Institute of Thailand, 191 Siriphanich Bldg., Huay Kaew Road, Suthep, Muang, Chiang Mai 50200 (Thailand); Fors, O. [Departament Astronomia i Meteorologia and Institut de Ciències del Cosmos (ICC), Universitat de Barcelona (UB/IEEC), Martí i Franqués 1, E-08028 Barcelona (Spain); Cusano, F. [INAF-Osservatorio Astronomico di Bologna, Via Ranzani 1, I-40127 Bologna (Italy); Ivanov, V. D., E-mail: andrea4work@gmail.com [European Southern Observatory, Ave. Alonso de Cordova 3107, Casilla 19001, Santiago 19 (Chile)

    2014-03-01

    We report on 13 subarcsecond binaries, detected by means of lunar occultations in the near-infrared at the ESO Very Large Telescope (VLT). They are all first-time detections except for the visual binary HD 158122, which we resolved for the first time in the near-infrared. The primaries have magnitudes in the range K = 4.5-10.0, and companions in the range K = 6.8-11.1. The magnitude differences have a median value of 2.4, with the largest being 4.6. The projected separations are in the range of 4-168 mas, with a median of 13 mas. We discuss and compare our results with the available literature. With this paper, we conclude the mining for binary star detections in the 1226 occultations recorded at the VLT with the ISAAC instrument. We expect that the majority of these binaries may be unresolvable by adaptive optics on current telescopes, and they might be challenging for long-baseline interferometry. However, they constitute an interesting sample for future larger telescopes and for astrometric missions such as GAIA.

  4. Subfracture insult to the human cadaver patellofemoral joint produces occult injury.

    Science.gov (United States)

    Atkinson, P J; Haut, R C

    1995-11-01

    The current criterion used by the automotive industry for injury to the lower extremity is based on visible bone fracture. Studies suggest, however, that chronic joint degeneration may occur after subfracture impact loads on the knee. We hypothesized that subfracture loading of the patellofemoral joint could result in previously undocumented microtrauma in areas of high contact pressure. In the current study, seven patellofemoral joints from human cadavers were subjected to impact with successively greater energy until visible fracture was noted. Transverse and comminuted fractures of the patella were noted at 6.7 kN of load. Approximately 45% of the impact energy then was delivered to the contralateral joint. Subfracture loads of 5.2 kN resulted in no gross bone fracture in five of seven specimens. Histological examination of the patellae horizontal split fracture in the subchondral bone, at the tidemark, or at the interface of calcified cartilage and subchondral bone. The trauma appeared predominantly on the lateral facet, adjacent to or directly beneath preexisting fibrillation of the articular surface. Surface fibrillation was noted in histological sections of control patellae (not subjected to impact loading), but occult damages were not observed. Although the mechanism of this occult trauma is unknown, similar damage has been shown to occur from direct shear loading. As these microcracks can potentiate a disease process in the joint, this study may suggest that the current criterion for injury, based on bone fracture alone, is not sufficiently conservative.

  5. Morphologically occult systemic mastocytosis in bone marrow: clinicopathologic features and an algorithmic approach to diagnosis.

    Science.gov (United States)

    Reichard, Kaaren K; Chen, Dong; Pardanani, Animesh; McClure, Rebecca F; Howard, Matthew T; Kurtin, Paul J; Wood, Adam J; Ketterling, Rhett P; King, Rebecca L; He, Rong; Morice, William G; Hanson, Curtis A

    2015-09-01

    Bone marrow (BM) biopsy specimens involved by systemic mastocytosis (SM) typically show multifocal, compact, dense aggregates of spindled mast cells (MCs). However, some cases lack aggregate formation and fulfill the World Health Organization 2008 criteria for SM, based on minor criteria. We identified 26 BM cases of KIT D816V-mutated, morphologically occult SM in the BM. All patients had some combination of allergic/MC activating symptoms. Peripheral blood counts were generally normal. BM aspirates showed 5% or less MCs, which were only occasionally spindled. BM biopsy specimens showed no morphologic classic MC lesions. Tryptase immunohistochemistry (IHC) demonstrated interstitial, individually distributed MCs (up to 5%) with prominent spindling, lacking aggregate formation. MCs coexpressed CD25 by IHC and/or flow cytometry. Spindled MCs constituted more than 25% of total MCs in all cases and more than 50% in 20 of 26 cases. Morphologically occult involvement of normal-appearing BM by SM will be missed without appropriate clinical suspicion and pathologic evaluation by tryptase and CD25 IHC and KIT D816V mutation analysis. On the basis of these findings, we propose a cost-effective, data-driven, evidence-based algorithmic approach to the workup of these cases. Copyright© by the American Society for Clinical Pathology.

  6. Occultations of Astrophysical Radio Sources as Probes of Planetary Environments: A Case Study of Jupiter and Possible Applications to Exoplanets

    Energy Technology Data Exchange (ETDEWEB)

    Withers, Paul [Astronomy Department, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States); Vogt, Marissa F. [Center for Space Physics, Boston University, 725 Commonwealth Avenue, Boston, MA 02215 (United States)

    2017-02-10

    Properties of planetary atmospheres, ionospheres, and magnetospheres are difficult to measure from Earth. Radio occultations are a common method for measuring these properties, but they traditionally rely on radio transmissions from a spacecraft near the planet. Here, we explore whether occultations of radio emissions from a distant astrophysical radio source can be used to measure magnetic field strength, plasma density, and neutral density around planets. In a theoretical case study of Jupiter, we find that significant changes in polarization angle due to Faraday rotation occur for radio signals that pass within 10 Jupiter radii of the planet and that significant changes in frequency and power occur from radio signals that pass through the neutral atmosphere. There are sufficient candidate radio sources, such as pulsars, active galactic nuclei, and masers, that occultations are likely to occur at least once per year. For pulsars, time delays in the arrival of their emitted pulses can be used to measure plasma density. Exoplanets, whose physical properties are very challenging to observe, may also occult distant astrophysical radio sources, such as their parent stars.

  7. MR imaging-guided sonography followed by fine-needle aspiration cytology in occult carcinoma of the breast

    NARCIS (Netherlands)

    A.I.M. Obdeijn (Inge-Marie); Brouwers-Kuyper, E.M.; M.M.A. Tilanus-Linthorst (Madeleine); T. Wiggers (Theo); M. Oudkerk (Matthijs)

    2000-01-01

    markdownabstractOBJECTIVE. In patients with axillary metastases as clinical evidence of possible occult breast cancer, a combined approach of MR imaging, sonography, and aspiration biopsy cytology was evaluated. SUBJECTS AND METHODS. Thirty-one women with metastatic adenocarcinoma in their

  8. Male occult triple-negative breast cancer with dermatomyositis: a case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Zhang L

    2017-11-01

    Full Text Available Le Zhang,1 Chenghua Zhang,2 Zhaoying Yang,1 Miao He,3 Lijuan Zhang,1 Shereen Ezzat,4 Xi Liang5 1Department of Breast Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China; 2Endoscopy Department, Jilin Cancer Hospital, Changchun, Jilin,China; 3Department of Anesthesia, The Second Hospital of Jilin University, Changchun, Jilin, China; 4Ontario Cancer Institute and The Endocrine Oncology Site Group, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada; 5Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China Abstract: Occult breast cancer is defined by the presence of axillary metastases without an identifiable primary breast tumor. Here, we report a rare case of a male occult breast cancer with dermatomyositis. We performed a modified radical mastectomy consisting of whole breast mastectomy and axillary lymph node dissection. Immunohistochemistry and fluorescent in situ hybridization analyses demonstrated an adenocarcinoma likely of breast origin, which was an occult triple-negative breast cancer. Interestingly, the patient’s previously noted periorbital dermatomyositis resolved promptly following surgical excision. Keywords: male breast cancer, occult breast cancer, triple-negative breast cancer, dermato­myositis 

  9. Detection of colorectal cancer in symptomatic outpatients without visible rectal bleeding: Validity of the fecal occult blood test

    DEFF Research Database (Denmark)

    Bjerregaard, Niels Christian; Tøttrup, Anders; Sørensen, Henrik Toft

    2009-01-01

    In 2002, a new diagnostic strategy in symptomatic outpatients without known established colorectal cancer risk factors aged 40 years or older was implemented in Denmark. Fecal occult blood test (Hemoccult Sensa®) was a part of that strategy in patients without visible rectal bleeding....

  10. Pluto's Atmosphere from the 2015 June 29 Ground-Based Stellar Occultation at the Time of the New Horizons Flyby

    Czech Academy of Sciences Publication Activity Database

    Sicardy, B.; Talbot, J.; Meza, E.; Camargo, J.I.B.; Desmars, J.; Gault, D.; Herald, D.; Kerr, S.; Pavlov, H.; Braga-Ribas, F.; Jelínek, Martin

    2016-01-01

    Roč. 819, č. 2 (2016), L38/1-L38/8 ISSN 2041-8205 Institutional support: RVO:67985815 Keywords : Kuiper belt objects * occultations * planets and satellites Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.522, year: 2016

  11. Pluto occultation on 2015 June 29 UTC with central flash and atmospheric spikes just before the New Horizons flyby

    Science.gov (United States)

    Pasachoff, Jay M.; Babcock, Bryce A.; Durst, Rebecca F.; Seeger, Christina H.; Levine, Stephen E.; Bosh, Amanda S.; Person, Michael J.; Sickafoose, Amanda A.; Zuluaga, Carlos A.; Kosiarek, Molly R.; Abe, Fumio; Nagakane, Masayuki; Suzuki, Daisuke; Tristram, Paul J.; Arredondo, Anicia

    2017-11-01

    We observed the occultation by Pluto of a 12th magnitude star, one of the two brightest occultation stars ever in our dozen years of continual monitoring of Pluto's atmosphere through such studies, on 2015 June 29 UTC. At the Univ. of Canterbury Mt. John Observatory (New Zealand), under clear skies throughout, we used a POETS frame-transfer CCD at 10 Hz with GPS timing on the 1-m McLellan telescope as well as an infrared camera on an 0.6-m telescope and three-color photometry at a slower cadence on a second 0.6-m telescope. At the Auckland Observatory, we used a POETS and a PICO on 0.5-m and 0.4-m telescopes, with 0.4 s and 2 s cadences, respectively, obtaining ingress observations before clouds moved in. The Mt. John light curves show a central flash, indicating that we were close to the center of the occultation path. Analysis of our light curves show that Pluto's atmosphere remains robust. The presence of spikes at both sites in the egress and ingress shows atmospheric layering. We coordinated our observations with aircraft observations (Bosh et al., 2017) with the Stratospheric Observatory for Infrared Astronomy (SOFIA). Our chords helped constrain the path across Pluto that SOFIA saw. Our ground-based and airborne stellar-occultation effort came only just over two weeks of Earth days and two Pluto days before the flyby of NASA's New Horizons spacecraft.

  12. Atmospheric influences on infrared-laser signals used for occultation measurements between Low Earth Orbit satellites

    Directory of Open Access Journals (Sweden)

    S. Schweitzer

    2011-10-01

    Full Text Available LEO-LEO infrared-laser occultation (LIO is a new occultation technique between Low Earth Orbit (LEO satellites, which applies signals in the short wave infrared spectral range (SWIR within 2 μm to 2.5 μm. It is part of the LEO-LEO microwave and infrared-laser occultation (LMIO method that enables to retrieve thermodynamic profiles (pressure, temperature, humidity and altitude levels from microwave signals and profiles of greenhouse gases and further variables such as line-of-sight wind speed from simultaneously measured LIO signals. Due to the novelty of the LMIO method, detailed knowledge of atmospheric influences on LIO signals and of their suitability for accurate trace species retrieval did not yet exist. Here we discuss these influences, assessing effects from refraction, trace species absorption, aerosol extinction and Rayleigh scattering in detail, and addressing clouds, turbulence, wind, scattered solar radiation and terrestrial thermal radiation as well. We show that the influence of refractive defocusing, foreign species absorption, aerosols and turbulence is observable, but can be rendered small to negligible by use of the differential transmission principle with a close frequency spacing of LIO absorption and reference signals within 0.5%. The influences of Rayleigh scattering and terrestrial thermal radiation are found negligible. Cloud-scattered solar radiation can be observable under bright-day conditions, but this influence can be made negligible by a close time spacing (within 5 ms of interleaved laser-pulse and background signals. Cloud extinction loss generally blocks SWIR signals, except very thin or sub-visible cirrus clouds, which can be addressed by retrieving a cloud layering profile and exploiting it in the trace species retrieval. Wind can have a small influence on the trace species absorption, which can be made negligible by using a simultaneously retrieved or a moderately accurate background wind speed profile. We

  13. Polarimetric mountain based radio-occultation for rain detection: The ROHP-PAZ ground campaign

    Science.gov (United States)

    Padulles, Ramon; Cardellach, Estel; Tomas, Sergio; de la Torre, Manuel; Turk, Joe

    2014-05-01

    The Radio Occultation and Heavy Precipitation experiment aboard the PAZ Low Earth Orbiter (ROHP-PAZ) is a mission of opportunity: The Spanish Ministry of Science and Innovation (MICINN) approved in 2009 a proposal to include a polarimetric Global Navigation Satellite System (GNSS) Radio-Occultation (RO) payload on board of the Spanish Earth Observation satellite PAZ. This will be a new technique that has never been tested before, that aims to improve the knowledge of precipitation through simultaneous thermodynamic and vertical rain profiles. Prior to the launch of the satellite, expected for 2014, a ground experimental campaign is being conducted with the goal of starting the process of identifying and understanding all the factors that might affect the polarimetric RO observables. The campaign is being carried out at the top of Puig Sesolles, a 1667m peak in the Natural Park of Montseny (41º46'24 N, 2º26'17 E), 50 km N-NE from Barcelona, with clear views over the horizon to the South (East to West) direction, an area in which intense precipitation events tend to occur a few times per year. The campaign uses a ICE-CSIC/IEEC's GOLD-RTR open-loop receiver initially designed for collecting GNSS signals reflected off the sea surface. The receiver has been adjusted to track occulting GNSS radio-links. A double polarization (H and V) GNSS antenna has been designed and manufactured by the Polytechnic University of Barcelona (UPC) team for this particular ground-based experiment. The antenna is a phase-array made of 7 elements, each of them being a square patch built using a Rogers 4003 substrate, and symmetrically fed by four probes. It provides a pattern of 12.9 dB peak gain, 45 degrees half-power beam-width, and <-35 dB cross-polar isolation at the peak (better than -30 dB in the main lobe). The preliminary results show that not only precipitation, but also other factors are affecting the GNSS signal, wich means that the polarimetric signal is richer than expected

  14. Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.

    Science.gov (United States)

    Kim, Myeong Hee; Kang, So Young; Lee, Woo In

    2017-05-01

    The aim of this study is to investigate the molecular characteristics of occult hepatitis B virus (HBV) infection in 'anti-HBc alone' subjects. Twenty-four patients with 'anti-HBc alone' and 20 control patients diagnosed with HBV were analyzed regarding S and pre-S gene mutations. All specimens were analyzed for HBs Ag, anti-HBc, and anti-HBs. For specimens with an anti-HBc alone, quantitative analysis of HBV DNA, as well as sequencing and mutation analysis of S and pre-S genes, were performed. A total 24 were analyzed for the S gene, and 14 were analyzed for the pre-S gene through sequencing. A total of 20 control patients were analyzed for S and pre-S gene simultaneously. Nineteen point mutations of the major hydrophilic region were found in six of 24 patients. Among them, three mutations, S114T, P127S/T, M133T, were detected in common. Only one mutation was found in five subjects of the control group; this mutation was not found in the occult HBV infection group, however. Pre-S mutations were detected in 10 patients, and mutations of site aa58-aa100 were detected in 9 patients. A mutation on D114E was simultaneously detected. Although five mutations from the control group were found at the same location (aa58-aa100), no mutations of occult HBV infection were detected. The prevalence of occult HBV infection is not low among 'anti-HBc alone' subjects. Variable mutations in the S gene and pre-S gene were associated with the occurrence of occult HBV infection. Further larger scale studies are required to determine the significance of newly detected mutations. © Copyright: Yonsei University College of Medicine 2017

  15. Local time dependence of the thermal structure in the Venusian equatorial region revealed by Akatsuki radio occultation measurements

    Science.gov (United States)

    Ando, H.; Fukuhara, T.; Takagi, M.; Imamura, T.; Sugimoto, N.; Sagawa, H.

    2017-12-01

    The radio occultation technique is one of the most useful methods to retrieve vertical temperature profiles in planetary atmospheres. Ultra-Stable Oscillator (USO) onboard Venus Climate Orbiter, Akatsuki, enables us to investigate the thermal structure of the Venus atmosphere between about 40-90 km levels. It is expected that 35 temperature profiles will be obtained by the radio occultation measurements of Akatsuki until August 2017. Static stability derived from the temperature profiles shows its local time dependence above the cloud top level at low-latitudes equatorward of 25˚. The vertical profiles of the static stability in the dawn and dusk regions have maxima at 77 km and 82 km levels, respectively. A general circulation model (GCM) for the Venus atmosphere (AFES-Venus) reproduced the thermal structures above the cloud top qualitatively consistent with the radio occultation measurements; the maxima of the static stability are seen both in the dawn and dusk regions, and the local maximum of the static stability in the dusk region is located at a highler level than in the dawn region. Comparing the thermal structures between the radio occultation measurements and the GCM results, it is suggested that the distribution of the static stability above the cloud top could be strongly affected by the diurnal tide. The thermal tide influences on the thermal structure as well as atmospheric motions above the cloud level. In addition, it is shown that zonally averaged zonal wind at about 80 km altitude could be roughly estimated from the radio occultation measurements using the dispersion relation of the internal gravity wave.

  16. Blockade of Cannabinoid CB1 Receptors in the Dorsal Periaqueductal Gray Unmasks the Antinociceptive Effect of Local Injections of Anandamide in Mice

    Directory of Open Access Journals (Sweden)

    Diego C. Mascarenhas

    2017-10-01

    Full Text Available Divergent results in pain management account for the growing number of studies aiming at elucidating the pharmacology of the endocannabinoid/endovanilloid anandamide (AEA within several pain-related brain structures. For instance, the stimulation of both Transient Receptor Potential Vanilloid type 1 (TRPV1 and Cannabinoid type 1 (CB1 receptors led to paradoxical effects on nociception. Here, we attempted to propose a clear and reproducible methodology to achieve the antinociceptive effect of exogenous AEA within the dorsal periaqueductal gray (dPAG of mice exposed to the tail-flick test. Accordingly, male Swiss mice received intra-dPAG injection of AEA (CB1/TRPV1 agonist, capsaicin (TRPV1 agonist, WIN (CB1 agonist, AM251 (CB1 antagonist, and 6-iodonordihydrocapsaicin (6-IODO (TRPV1 selective antagonist and their nociceptive response was assessed with the tail-flick test. In order to assess AEA effects on nociception specifically at vanilloid or cannabinoid (CB substrates into the dPAG, mice underwent an intrinsically inactive dose of AM251 or 6-IODO followed by local AEA injections and were subjected to the same test. While intra-dPAG AEA did not change acute pain, local injections of capsaicin or WIN induced a marked TRPV1- and CB1-dependent antinociceptive effect, respectively. Regarding the role of AEA specifically at CB/vanilloid substrates, while the blockade of TRPV1 did not change the lack of effects of intra-dPAG AEA on nociception, local pre-treatment of AM251, a CB1 antagonist, led to a clear AEA-induced antinociception. It seems that the exogenous AEA-induced antinociception is unmasked when it selectively binds to vanilloid substrates, which might be useful to address acute pain in basic and perhaps clinical trials.

  17. Can a pile of scrap unmask a new high technology? The A4/V-2 No V89 Bäckebo-torpeden

    Science.gov (United States)

    Ingemar Skoog, A.

    2013-04-01

    Three months before the first V-2 rocket attack on London a test vehicle crashed in southern Sweden on June 13, 1944. At this time the Allied only had limited knowledge about the rocket (A4/V-2) from agent reports and information from the Polish resistance investigating some remains from a crashed test vehicle in Poland. London was confronted with a new weapon supposedly able to carry an explosive warhead of several tons some 250 km. The A4/V-2 rocket test vehicle number V89 broke apart shortly before impacting ground. In a short time 2 t of metal parts and electrical equipment was collected and transported to Stockholm for investigations. A first Swedish report was ready by July 21, 1944 and the rocket parts were then transported to England for further investigations. By August 18, 1944 the Royal Aircraft Establishment (RAE) had its preliminary report ready. But how close to reality can a complex vehicle be reconstructed and the performance calculated from a pile of scrap by investigators dealing with a technology not seen before? In the early 1940s the state of art of liquid propellant rocket technology outside Germany was limited and the size of a liquid rocket engine for the likely performance hardly imaginable. The Swedish and British reports, at that time classified as top secret, have since been released and permit a very detailed analysis of the task to reconstruct the rocket vehicle, the engine itself and its performance. An assessment of the occurrence at Peenemünde and how the rocket became astray and fell in southern Sweden, together with the analyses by Swedish and British military investigators give a unique insight into the true nature of the V89. It shows the real capabilities of early aeronautical accident investigation methods in combination with solid engineering knowledge to unmask a new high technology.

  18. Stratospheric gravity wave activities inferred through the GPS radio occultation technique

    International Nuclear Information System (INIS)

    Wrasse, Cristiano Max; Takahashi, Hisao; Fechine, Joaquim; Denardini, Clezio Marcos; Wickert, Jens

    2007-01-01

    Stratospheric gravity wave activities were deduced from GPS radio occultation temperature profiles obtained by CHAMP satellite between 2001 and 2005. Potential energy profiles are used to analyze the gravity wave activity over South America. The results showed an inter-annual variation of the potential energy integrated between 24 and 34 km of altitude. The gravity wave activity is more concentrated around the equatorial region. In order to evaluate the seasonal variation of the gravity wave activity, a mean potential energy was determined over (10 deg N-10 deg S) and (100 deg W-20 deg W). The results showed a lower gravity wave activity during winter time, while during spring time the mean potential energy showed an increase in the wave activity. The results of the mean potential energy also showed that the gravity wave activity in the lower stratosphere exhibits a higher wave activity during 2002 and 2004 and a lower wave activity during 2003 and 2005. (author)

  19. Large Binocular Telescope Observations of Europa Occulting Io's Volcanoes at 4.8 μm

    Science.gov (United States)

    Skrutskie, Michael F.; Conrad, Albert; Resnick, Aaron; Leisenring, Jarron; Hinz, Phil; de Pater, Imke; de Kleer, Katherine; Spencer, John; Skemer, Andrew; Woodward, Charles E.; Davies, Ashley Gerard; Defrére, Denis

    2015-11-01

    On 8 March 2015 Europa passed nearly centrally in front of Io. The Large Binocular Telescope observed this event in dual-aperture AO-corrected Fizeau interferometric imaging mode using the mid-infrared imager LMIRcam operating behind the Large Binocular Telescope Interferometer (LBTI) at a broadband wavelength of 4.8 μm (M-band). Occultation light curves generated from frames recorded every 123 milliseconds show that both Loki and Pele/Pillan were well resolved. Europa's center shifted by 2 kilometers relative to Io from frame-to-frame. The derived light curve for Loki is consistent with the double-lobed structure reported by Conrad et al. (2015) using direct interferometric imaging with LBTI.

  20. Using 18F FDG PET/CT to Detect an occult Mesenchymal Tumor Causing Oncogenic Osteomalacia

    International Nuclear Information System (INIS)

    Seo, Hyo Jung; Choi, Yun Jung; Kim, Hyun Jeong; Jeong, Yong Hyu; Cho, Arthur; Lee, Jae Hoon; Yun, Mijin; Lee, Jong Doo; Kang, Won Jun

    2011-01-01

    Oncogenic osteomalacia is a rare paraneoplastic syndrome characterized by renal phosphate excretion, hypophosphatemia, and osteomalacia. This syndrome is often caused by tumors of mesenchymal origin. Patients with oncogenic osteomalacia have abnormal bone mineralization, resulting in a high frequency of fractures. Tumor resection is the treatment of choice, as it will often correct the metabolic imbalance. Although oncogenic osteomalacia is a potentially curable disease, diagnosis is difficult and often delayed because of the small size and sporadic location of the tumor. Bone scintigraphy and radiography best characterize osteoma lacia; magnetic resonance imaging findings are nonspecific. Here, we report a case of oncogenic osteomalacia secondary to a phosphaturic mesenchymal tumor that was successfully detected by 18F fluorodeoxyglucose positron emission tomography/computed tomography ( 18F FDG PET/CT). This case illustrates the advantages of 18F FDG PET/CT in detecting the occult mesenchymal tumor that causes oncogenic osteomalacia.

  1. Occult Plastic Intravitreal Foreign Body Retained for 30 Years: A Case Report

    Directory of Open Access Journals (Sweden)

    Hsien-Chung Lin

    2006-10-01

    Full Text Available A 41-year-old man had suffered trauma to the right eye 30 years ago. In March 1996, he underwent trabeculectomy and peripheral iridectomy under the diagnosis of open angle glaucoma in the right eye. Autoperimetry at that time revealed visual field constriction. In addition, ocular examination showed that the cup/disc ratio of his right eye was increased. Cataract was diagnosed in September 2002 and cataract extraction was performed on October 22, 2002. A plastic intravitreal foreign body was detected during the operation. However, preoperative B-scan ultrasonography had failed to detect an intraocular foreign body (IOFB, and the previous fluorescein angiography had shown only retinal pigment epithelium changes. This case reminded us that we should be alert to an occult IOFB in the event of ocular trauma, even if none had been detected during prior imaging examinations.

  2. Sonography of occult rib and costal cartilage fractures: a case series.

    Science.gov (United States)

    Mattox, Ross; Reckelhoff, Kenneth E; Welk, Aaron B; Kettner, Norman W

    2014-06-01

    The purpose of this case series is to describe the use of diagnostic ultrasound (US) in the detection of occult rib and costal cartilage fractures presenting as chest wall pain to a chiropractic clinic. Three patients presented with chest wall pain and tenderness. Two of the patients presented with acute chest wall injury and 1 carried a previous diagnosis of rib fracture after trivial trauma 2 months earlier. Diagnostic US was selected as a non-ionizing imaging tool for these patients after negative digital radiography studies. All fractures were considered isolated as there was no associated injury, such as pneumothorax. Both of the acute cases were followed up to complete healing (evidence of osseous union) using US. All patients eventually achieved pain-free status. In these cases, US was more sensitive than radiography for diagnosing these cases of acute rib and costal cartilage fractures. Early recognition of rib injury could avoid potential complications from local manipulative therapy.

  3. Upper Troposphere Lower Stratosphere structure during convective systems using GPS radio occultations

    DEFF Research Database (Denmark)

    Biondi, Riccardo

    The deep convective systems play a fundamental role in atmospheric circulation and climate. Thunderstorms and meso-scale convective systems produce fast vertical transport, redistributing water vapor and trace gases and influencing the thermal structure of the upper troposphere and lower...... stratosphere (UTLS) contributing to the troposphere-stratosphere transport and affecting the Earth global circulation and the climate changes. The Global Positioning System (GPS) Radio Occultation (RO) technique enables measurement of atmospheric density structure in any meteorological condition...... to the analysis of tropical storms for the future mission ACES will also be evaluated. Using data from the past and ongoing GPS RO missions we have defined an algorithm to detect the clouds top of the convective systems and their thermal structure. Other satellite and in-situ measurements co-located with GPS ROs...

  4. Modelling the phase curve and occultation of WASP-43b with SPIDERMAN

    Science.gov (United States)

    Louden, Tom

    2017-06-01

    Presenting SPIDERMAN, a fast code for calculating exoplanet phase curves and secondary eclipses with arbitrary two dimensional surface brightness distributions. SPIDERMAN uses an exact geometric algorithm to calculate the area of sub-regions of the planet that are occulted by the star, with no loss in numerical precision. The speed of this calculation makes it possible to run MCMCs to marginalise effectively over the underlying parameters controlling the brightness distribution of exoplanets. The code is fully open source and available over Github. We apply the code to the phase curve of WASP-43b using an analytical surface brightness distribution, and find an excellent fit to the data. We are able to place direct constraints on the physics of heat transport in the atmosphere, such as the ratio between advective and radiative timescales at different altitudes.

  5. First operations of the SOIR occultation infrared spectrometer in Venus orbit.

    Science.gov (United States)

    Nevejans, D.; Neefs, E.; Vandaele, A. C.; Muller, C.; Fussen, D.; Berkenbosch, S.; Clairquin, R.; Korablev, O.; Federova, A.; Bertaux, J. L.

    Since May 2006, the Venus-Express spacecraft is in its nominal orbit around VENUS and the SPICAV optical package has begun to acquire spectra. The SOIR extension to SPICAV is an echelle spectrometer associated to an AOTF (Acousto-Optical Tunable Filter) for the order selection, which performs solar occultation measurements in the IR region (2.2-4.3 µm) at a resolution of 0.1 cm-1 . The detailed optical study and design as well as the manufacturing were performed at the BIRA/IASB in collaboration with its industrial partners OIP and PEDEO. It was funded by the Belgian Federal Science Policy Office under the ESA PRODEX programme. The wavelength range allows a detailed chemical inventory of the Venus atmosphere above the cloud layer with an emphasis on vertical distribution of gases. The first results look promising and will be qualitatively presented.

  6. Clinical results of stereotactic heavy-charged-particle radiosurgery for intracranial angiographically occult vascular malformations

    International Nuclear Information System (INIS)

    Levy, R.P.; Fabrikant, J.I.; Phillips, M.H.; Frankel, K.A.; Steinberg, G.K.; Marks, M.P.; DeLaPaz, R.L.; Chuang, F.Y.S.; Lyman, J.T.

    1989-12-01

    Angiographically occult vascular malformations (AOVMs) of the brain have been recognized for many years to cause neurologic morbidity and mortality. They generally become symptomatic due to intracranial hemorrhage, focal mass effect, seizures or headaches. The true incidence of AOVMs is unknown, but autopsy studies suggest that they are more common than high-flow angiographically demonstrable arteriovenous malformations (AVMs). We have developed stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of inoperable intracranial vascular malformations, using the helium ion beams at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron and Bevatron. This report describes the protocol for patient selection, radiosurgical treatment planning method, clinical and neuroradiologic results and complications encountered, and discusses the strengths and limitations of the method. 10 refs., 1 fig

  7. Clinical results of stereotactic heavy-charged-particle radiosurgery for intracranial angiographically occult vascular malformations

    Energy Technology Data Exchange (ETDEWEB)

    Levy, R.P.; Fabrikant, J.I.; Phillips, M.H.; Frankel, K.A.; Steinberg, G.K.; Marks, M.P.; DeLaPaz, R.L.; Chuang, F.Y.S.; Lyman, J.T.

    1989-12-01

    Angiographically occult vascular malformations (AOVMs) of the brain have been recognized for many years to cause neurologic morbidity and mortality. They generally become symptomatic due to intracranial hemorrhage, focal mass effect, seizures or headaches. The true incidence of AOVMs is unknown, but autopsy studies suggest that they are more common than high-flow angiographically demonstrable arteriovenous malformations (AVMs). We have developed stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of inoperable intracranial vascular malformations, using the helium ion beams at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron and Bevatron. This report describes the protocol for patient selection, radiosurgical treatment planning method, clinical and neuroradiologic results and complications encountered, and discusses the strengths and limitations of the method. 10 refs., 1 fig.

  8. Occult Leydig Cell Tumour Presenting as Bilateral Gynaecomastia. Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    A. B. Patel

    2005-01-01

    Full Text Available Gynaecomastia is the most common benign breast disorder in men. Among the various causes, testicular malignancies are an uncommon, life-threatening condition requiring prompt diagnosis and treatment. The case of a 28-year-old man is discussed, who presented with a 6-month history of painful bilateral gynaecomastia with no abnormality on clinical or biochemical examination. The patient's symptoms spontaneously resolved within 4 weeks. He then represented 10 years later with similar symptoms and an associated secondary hypogonadism. Ultrasound imaging revealed a clinically occult, hypoechoic mass in the left testis (Leydig cell tumour on histology. Clinical and hormonal findings normalized following surgical excision. This report underlines the importance in clinical practice of ultrasonographic evaluation of the testis, in all patients with gynaecomastia, despite unremarkable findings on physical examination.

  9. Development of an Intervention for implementing Immunochemical Faecal Occult Blood Test in General Practice

    DEFF Research Database (Denmark)

    Juul, Jakob Søgaard; Vedsted, Peter; Bro, Flemming

    2016-01-01

    Denne korte artikel handler om udviklingen af en intervention til implementering af immunochemical faecal occult blood test (iFOBT) i almen praksis. Artiklen gennemgår processen fra de tidlige udviklingsstadier, over pilot-testning og frem til de endelige justeringer før selve implementeringen blev...... vurdering og viden om patienten. Kombinationen af teori og praksis viste sig at være en god måde at sikre hurtig ibrugtagning af en ny test i almen praksis til at identificere potentielle tegn på tarmkræft hos patienter. Særligt pilot-testning af interventionen viste sig at være værdifuld, fordi den...

  10. Infectivity of blood products from donors with occult hepatitis B virus infection

    DEFF Research Database (Denmark)

    Allain, Jean-Pierre; Mihaljevic, Ivanka; Gonzalez-Fraile, Maria Isabel

    2013-01-01

    BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) is identified in 1:1000 to 1:50,000 European blood donations. This study intended to determine the infectivity of blood products from OBI donors. STUDY DESIGN AND METHODS: Recipients of previous donations from OBI donors were investigated...... blood cells [RBCs], p Donor and recipient strains sequence homology of at least 99% confirmed transfusion-transmitted infection in 10 cases and excluded it in one case. CONCLUSION: Blood...... through lookback (systematic retrieval of recipients) or traceback (triggered by clinical cases). Serologic and genomic studies were undertaken on consenting donors and recipients. Multiple variables potentially affecting infectivity were examined. RESULTS: A total of 45 of 105 (42.9%) donor...

  11. Immunochemical faecal occult blood test for colorectal cancer screening: a systematic review.

    Science.gov (United States)

    Syful Azlie, M F; Hassan, M R; Junainah, S; Rugayah, B

    2015-02-01

    A systematic review on the effectiveness and costeffectiveness of Immunochemical faecal occult IFOBT for CRC screening was carried out. A total of 450 relevant titles were identified, 41 abstracts were screened and 18 articles were included in the results. There was fair level of retrievable evidence to suggest that the sensitivity and specificity of IFOBT varies with the cut-off point of haemoglobin, whereas the diagnostic accuracy performance was influenced by high temperature and haemoglobin stability. A screening programme using IFOBT can be effective for prevention of advanced CRC and reduced mortality. There was also evidence to suggest that IFOBT is cost-effective in comparison with no screening, whereby a two-day faecal collection method was found to be costeffective as a means of screening for CRC. Based on the review, quantitative IFOBT method can be used in Malaysia as a screening test for CRC. The use of fully automated IFOBT assay would be highly desirable.

  12. A research about characteristics of longitudinal variations of ES layers irregularities based on CHAMP occultation measurements

    Science.gov (United States)

    Liao, Sunmin

    2018-04-01

    Based on the data of CHAMP occultation measurements, this paper makes a preliminary analysis of the longitudinal variations of ES irregular structure by using Fourier decomposition and reconstruction technique. It is found that the longitudinal variations of the ES irregular structure show the features of multiple wave-numbers, which is dominated by the wave number 1 to the wave number 5 components, and decrease from the amplitudes of the wave number 6 components. The features of wave number structures are very different in different DIP latitude and different seasons. The number of crests in summer and autumn is mostly 3 or 4 crest structures, while the number of crests in spring achieves 5 at DIP 15°N with small fluctuates, the crests number of winter is the least. In the multiple wave-numbers structure, the wave number 4 component shows a significant dependence on the season, mainly in the summer and autumn, particularly obvious from July to October.

  13. Quantification of abnormal intracranial pressure waves and isotope cisternography for diagnosis of occult communicating hydrocephalus

    International Nuclear Information System (INIS)

    Cardoso, E.R.; Piatek, D.; Del Bigio, M.R.; Stambrook, M.; Sutherland, J.B.

    1989-01-01

    Nineteen consecutive patients with suspected occult communicating hydrocephalus were investigated by means of clinical evaluation, neuropsychological testing, isotope cisternography, computed tomography scanning, and continuous intracranial pressure monitoring. Semi-quantitative grading systems were used in the evaluation of the clinical, neuropsychological, and cisternographic assessments. Clinical examination, neuropsychological testing, and computed tomography scanning were repeated 3 months after ventriculoperitoneal shunting. All patients showed abnormal intracranial pressure waves and all improved after shunting. There was close correlation between number, peak, and pulse pressures of B waves and the mean intracranial pressure. However, quantification of B waves by means of number, frequency, and amplitude did not help in predicting the degree of clinical improvement postshunting. The most sensitive predictor of favorable response to shunting was enlargement of the temporal horns on computed tomography scan. Furthermore, the size of temporal horns correlated with mean intracranial pressure. There was no correlation between abnormalities on isotope cisternography and clinical improvement

  14. Utility of the serum C-reactive protein for detection of occult bacterial infection in children.

    Science.gov (United States)

    Isaacman, Daniel J; Burke, Bonnie L

    2002-09-01

    To assess the utility of serum C-reactive protein (CRP) as a screen for occult bacterial infection in children. Febrile children ages 3 to 36 months who visited an urban children's hospital emergency department and received a complete blood cell count and blood culture as part of their evaluation were prospectively enrolled from February 2, 2000, through May 30, 2001. Informed consent was obtained for the withdrawal of an additional 1-mL aliquot of blood for use in CRP evaluation. Logistic regression and receiver operator characteristic (ROC) curves were modeled for each predictor to identify optimal test values, and were compared using likelihood ratio tests. Two hundred fifty-six patients were included in the analysis, with a median age of 15.3 months (range, 3.1-35.2 months) and median temperature at triage 40.0 degrees C (range, 39.0 degrees C-41.3 degrees C). Twenty-nine (11.3%) cases of occult bacterial infection (OBI) were identified, including 17 cases of pneumonia, 9 cases of urinary tract infection, and 3 cases of bacteremia. The median white blood cell count in this data set was 12.9 x 10(3)/ micro L [corrected] (range, 3.6-39.1 x10(3)/ micro L) [corrected], the median absolute neutrophil count (ANC) was 7.12 x 10(3)/L [corrected] (range, 0.56-28.16 x10(3)/L) [corrected], and the median CRP level was 1.7 mg/dL (range, 0.2-43.3 mg/dL). The optimal cut-off point for CRP in this data set (4.4 mg/dL) achieved a sensitivity of 63% and a specificity of 81% for detection of OBI in this population. Comparing models using cut-off values from individual laboratory predictors (ANC, white blood cell count, and CRP) that maximized sensitivity and specificity revealed that a model using an ANC of 10.6 x10(3)/L [corrected] (sensitivity, 69%; specificity, 79%) was the best predictive model. Adding CRP to the model insignificantly increased sensitivity to 79%, while significantly decreasing specificity to 50%. Active monitoring of emergency department blood cultures

  15. Synchronous occult metastasising duodenal carcinoid and ovarian mucinous cystadenocarcinoma- Multiple primary malignancies in the same patient

    Directory of Open Access Journals (Sweden)

    Devadass Clement W, Sridhar Honnappa, Aarathi R Rau, Sharat Chandra

    2014-01-01

    Full Text Available Gastrointestinal carcinoid tumors are uncommon neuroendocrine tumours that may be associated with synchronous or metachronous primary tumours of other histological type, most frequently colorectal adenocarcinomas. Primary ovarian mucinous adenocarcinomas have been reported to coincide with few other ovarian tumours and minority of these tumours may occur in association with Lynch syndrome. However association of duodenal carcinoid with ovarian mucinous adenocarcinoma is distinctly unusual and, to our knowledge, has not been previously described. We report a case of occult metastasising duodenal atypical carcinoid that was incidentally detected during surgical intervention performed for left ovarian mucinous cystadenocarcinoma in a middle aged female. The carcinoid tumour was Stage IIIB with regional nodal metastasis and the ovarian tumour was Stage IA with low grade histology.

  16. Internal gravity waves in Titan's atmosphere observed by Voyager radio occultation

    Science.gov (United States)

    Hinson, D. P.; Tyler, G. L.

    1983-01-01

    The radio scintillations caused by scattering from small-scale irregularities in Titan's neutral atmosphere during a radio occultation of Voyager 1 by Titan are investigated. Intensity and frequency fluctuations occurred on time scales from about 0.1 to 1.0 sec at 3.6 and 13 cm wavelengths whenever the radio path passed within 90 km of the surface, indicating the presence of variations in refractivity on length scales from a few hundred meters to a few kilometers. Above 25 km, the altitude profile of intensity scintillations closely agrees with the predictions of a simple theory based on the characteristics of internal gravity waves propagating with little or no attenuation through the vertical stratification in Titan's atmosphere. These observations support a hypothesis of stratospheric gravity waves, possibly driven by a cloud-free convective region in the lowest few kilometers of the stratosphere.

  17. The atmosphere of Uranus - Results of radio occultation measurements with Voyager 2

    Science.gov (United States)

    Lindal, G. F.; Lyons, J. R.; Sweetnam, D. N.; Eshleman, V. R.; Hinson, D. P.

    1987-01-01

    The Uranian atmosphere is investigated on the basis of S-band and X-band occultation observations (including measurements of Doppler frequency perturbations) obtained during the Voyager 2 encounter with Uranus in January 1986. The data are presented in extensive tables and graphs and characterized in detail. The atmosphere is assumed to have an H2/He abundance ratio of about 85/15, but also to contain small amounts of CH4 at above-cloud relative humidity 30 percent, cloud-base relative humidity 78 percent, and below-cloud mixing ratio 2.3 percent by number density. Other parameters estimated include magnetic-field rotation period 17.24 h, 1-bar equatorial radius 25,559 + or - 4 km, polar radius 24,973 + or - 20 km, equatorial acceleration of gravity 8.69 + or - 0.01 m/sec sq, and atmospheric temperature 76 + or - 2 K (assuming 85 + or - 3 percent H2).

  18. The atmosphere of Neptune - Results of radio occultation measurements with the Voyager 2 spacecraft

    Science.gov (United States)

    Lindal, G. F.; Lyons, J. R.; Sweetnam, D. N.; Eshleman, V. R.; Hinson, D. P.

    1990-01-01

    This paper presents the vertical temperature and composition profiles of Neptune's troposphere and stratosphere, covering an altitude of 250 km, obtained from radio tracking data that were acquired during Voyager-2's occultation by Neptune, which began near 62 deg N planetographic latitude and ended near 45 deg S latitude. In the computations, the He/H2 abundance ratio 15/85 was adapted, which is consistent with solar abundance estimates and with recent results from Uranus. It was assumed that aerosols and heavier gases such as CH4, NH3, H2S, and H2O have a negligible effect on the microwave refractivity above the 0.5 bar pressure level.

  19. Use of the blue cotton screen method with endoscopy to detect occult esophageal foreign bodies.

    Science.gov (United States)

    Xia, Yan; Zhang, Fan; Xu, Hong; Xu, Weiran

    2017-12-01

    More than 20,000 cases of upper gastrointestinal foreign bodies (FBs) have been reported in the last 5 years in China. Early detection and treatment is vital in these patients. Differential diagnosis of esophageal injury and occult esophageal foreign bodies is challenging, particularly in the case of non-radio-opaque foreign bodies. A diagnostic technique with high accuracy and low risk is needed for clinical practice. We describe successful use of the "blue cotton screen method" to detect esophageal foreign bodies in 2 patients. The advantages and disadvantages of various diagnostic modalities in the management of patients with foreign body ingestion are presented. This technique is safer and more effective than traditional methods for foreign body impaction in the esophageal cavity. It could be applied for screening and in the differential diagnosis of esophageal injury and FBs in the esophageal lumen.

  20. Total Artificial Heart Bridge to Transplantation for a Patient With Occult Intracardiac Malignancy: Case Report.

    Science.gov (United States)

    Reich, H; Czer, L; Bannykh, S; De Robertis, M; Wolin, E; Amersi, F; Moriguchi, J; Kobashigawa, J; Arabia, F

    2015-09-01

    Malignancy is the leading cause of long-term morbidity and mortality after heart and other solid organ transplantation; therefore, great emphasis is placed on pre- and post-transplantation cancer screening. Even with meticulous screening during evaluation for heart transplant candidacy, an occult cancer may not be apparent. Here, we share the case of a 51-year-old man with refractory heart failure who underwent total artificial heart implantation as a bridge to transplantation with the surprise finding of an isolated deposit of metastatic carcinoid tumor nested within a left ventricular papillary muscle in his explanted heart. The primary ileal carcinoid tumor was identified and resected completely. After remaining cancer-free for 14 months, he was listed for heart transplantation and was transplanted 2 months later. He is currently 3.5 months out from heart transplantation and doing well, without evidence of recurring malignancy. Copyright © 2015 Elsevier Inc. All rights reserved.

  1. Effects of turbulence on average refraction angles in occultations by planetary atmospheres

    Science.gov (United States)

    Eshleman, V. R.; Haugstad, B. S.

    1978-01-01

    Four separable effects of atmospheric turbulence on average refraction angles in occultation experiments are derived from a simplified analysis, and related to more general formulations by B. S. Haugstad. The major contributors are shown to be due to gradients in height of the strength of the turbulence, and the sense of the resulting changes in refraction angles is explained in terms of Fermat's principle. Because the results of analyses of such gradient effects by W. B. Hubbard and J. R. Jokipii are expressed in other ways, a special effort is made to compare all of the predictions on a common basis. We conclude that there are fundamental differences, and use arguments based on energy conservation and Fermat's principle to help characterize the discrepancies.

  2. Ernst Haeckel's biodynamics 1866 and the occult basis of organic farming

    Science.gov (United States)

    Kutschera, Ulrich

    2016-01-01

    ABSTRACT One hundred and 50 years ago (Sept. 1866), Ernst Haeckel published a monograph entitled General Morphology of Organisms, wherein key terms, such as Protista, Monera, ontogeny, phylogeny, ecology and the ‘biogenetic law’ where introduced. In addition, Haeckel coined the word “biodynamics” as a synonym for “general physiology.” In contrast, Rudolf Steiner's “biodynamic agriculture,” which originated in 1924, and was promoted via Ehrenfried Pfeiffer's book of 1938 with the same title, is an occult pseudoscience still popular today. The misuse of Haeckel's term to legitimize disproven homeopathic principles and esoteric rules within the context of applied plant research is unacceptable. PMID:27322020

  3. Analysis of macular cone photoreceptors in a case of occult macular dystrophy

    Directory of Open Access Journals (Sweden)

    Tojo N

    2013-05-01

    Full Text Available Naoki Tojo Tomoko Nakamura Hironori Ozaki Miyako Oka Toshihiko Oiwake Atsushi HayashiDepartment of Ophthalmology, University of Toyama, Toyama, JapanPurpose: To investigate changes in cone photoreceptors with adaptive optics (AO fundus imaging and spectral domain optical coherence tomography (SD-OCT in a case of occult macular dystrophy (OMD.Patient and methods: Both eyes of a 42-year-old woman diagnosed with OMD were examined. We used an AO fundus camera to obtain images of cone photoreceptors in the macula of the OMD subject and five healthy control subjects. Correlations between the AO images and the SD-OCT images were examined. Cone photoreceptors in eight areas in the macula of OMD and healthy control subjects were analyzed and compared.Results: SD-OCT showed a loss of the cone outer-segment tips line outside of the fovea in both eyes of the subject with OMD. The left eye with decreased visual acuity showed a discontinuous photoreceptor inner-segment and outer-segment line and cone outer-segment tips line at the fovea in SD-OCT and loss of cone mosaics as a dark spot in the AO image. In panoramic AO images and cone-density maps, less cone density was observed in a ring-like region outside the fovea than in the peripheral retina. In most of the areas examined, the cone densities were lower in the OMD eyes than in the healthy control eyes.Conclusions: Cone densities in the macula of the OMD patient were greatly decreased. AO images were found to be useful to evaluate morphologic changes in cone photoreceptors in patients with OMD.Keywords: occult macular dystrophy, adaptive optics, cone photoreceptor, cone analysis, optical coherence tomography

  4. Dynamic statistical optimization of GNSS radio occultation bending angles: advanced algorithm and performance analysis

    Science.gov (United States)

    Li, Y.; Kirchengast, G.; Scherllin-Pirscher, B.; Norman, R.; Yuan, Y. B.; Fritzer, J.; Schwaerz, M.; Zhang, K.

    2015-08-01

    We introduce a new dynamic statistical optimization algorithm to initialize ionosphere-corrected bending angles of Global Navigation Satellite System (GNSS)-based radio occultation (RO) measurements. The new algorithm estimates background and observation error covariance matrices with geographically varying uncertainty profiles and realistic global-mean correlation matrices. The error covariance matrices estimated by the new approach are more accurate and realistic than in simplified existing approaches and can therefore be used in statistical optimization to provide optimal bending angle profiles for high-altitude initialization of the subsequent Abel transform retrieval of refractivity. The new algorithm is evaluated against the existing Wegener Center Occultation Processing System version 5.6 (OPSv5.6) algorithm, using simulated data on two test days from January and July 2008 and real observed CHAllenging Minisatellite Payload (CHAMP) and Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) measurements from the complete months of January and July 2008. The following is achieved for the new method's performance compared to OPSv5.6: (1) significant reduction of random errors (standard deviations) of optimized bending angles down to about half of their size or more; (2) reduction of the systematic differences in optimized bending angles for simulated MetOp data; (3) improved retrieval of refractivity and temperature profiles; and (4) realistically estimated global-mean correlation matrices and realistic uncertainty fields for the background and observations. Overall the results indicate high suitability for employing the new dynamic approach in the processing of long-term RO data into a reference climate record, leading to well-characterized and high-quality atmospheric profiles over the entire stratosphere.

  5. Outcome analysis of salvage radiotherapy for occult cervical cancer found after simple hysterectomy

    International Nuclear Information System (INIS)

    Koh, Hyeon-Kang; Jeon, Wan; Kim, Hak-Jae; Wu, Hong-Gyun; Kim, Kyubo; Chie, Eui-Kyu; Ha, Sung-W.

    2013-01-01

    The objective was to analyze the outcomes of the patients, who received salvage radiotherapy for incidentally discovered cervical cancer following simple hysterectomy, and to identify the influence of intracavitary radiotherapy on treatment outcomes. Data from 117 patients with occult cervical cancer who underwent simple hysterectomy followed by salvage radiotherapy from September 1979 to November 2010 were collected. All the patients received external beam radiotherapy with (n=45) or without (n=72) intracavitary radiotherapy. Local control, disease-free survival, overall survival and treatment-related toxicity were investigated. The median follow-up time was 75 months. The 5- and 10-year local control/disease-free survival/overall survival rates were 93/87/87% and 90/84/83%, respectively. Among 98 patients who had no residual disease and negative resection margin on surgical specimens, 32 (33%) received intracavitary radiotherapy and 66 (67%) did not. There were no differences in patient and tumor characteristics between patients treated with and without intracavitary radiotherapy. The 5-year local control rate for the non-intracavitary radiotherapy group was 93 versus 94% for the intracavitary radiotherapy group (P=0.564); the disease-free survival rate was 88 versus 94% (P=0.894); the overall survival rate was 95 versus 85% (P=0.106), respectively. Among all patients, there were 5% of Grade 3 or higher late toxicities. Patients with occult invasive cervical cancer discovered following simple hysterectomy could be treated safely and effectively with salvage radiotherapy. For patients with no residual disease and negative resection margin, intracavitary radiotherapy could be omitted. (author)

  6. Prevalence of occult hepatitis C virus infection in the Iranian patients with human immunodeficiency virus infection.

    Science.gov (United States)

    Bokharaei-Salim, Farah; Keyvani, Hossein; Esghaei, Maryam; Zare-Karizi, Shohreh; Dermenaki-Farahani, Sahar-Sadat; Hesami-Zadeh, Khashayar; Fakhim, Shahin

    2016-11-01

    Occult hepatitis C virus (HCV) infection is a new form of chronic HCV infection described by the presence of the genomic HCV-RNA in liver biopsy and/or peripheral blood mononuclear cell (PBMC) samples, and undetectable levels or absence of HCV-RNA and in the absence or presence of anti HCV antibodies in the plasma specimens. The aim of the present study was to evaluate the occurrence of occult HCV infection (OCI) among Iranian subjects infected with human immunodeficiency virus (HIV) using RT-nested PCR. From March 2014 until April 2015, 109 Iranian patients with established HIV infection were enrolled in this cross-sectional study. After extraction of viral RNA from the plasma and PBMC samples, HCV-RNA status was examined by RT-nested PCR using primers from the 5'-NTR. HCV genotyping was conducted using RFLP analysis. For the confirmation of HCV genotyping by RFLP method, the PCR products were sequenced. Of the 109 patients, 50 were positive for antibodies against HCV. The HCV-RNA was detected in PBMC specimens in 6 (10.2%) out of the total 59 patients negative for anti-HCV Abs and undetectable plasma HCV-RNA and also from 4 (8.0%) out of the total 50 patients positive for anti-HCV Abs and undetectable plasma HCV-RNA. HCV genotyping analysis showed that 6 (60.0%) patients were infected with HCV subtype 3a, 3 (30.0%) were infected with HCV subtype 1a and 1 (10.0%) patient was infected with HCV subtype 1b. This study revealed the incidence of OCI (9.2%) in HIV-infected Iranian patients. Hence, designing prospective studies focusing on the detection of OCI in these patients would provide more information. J. Med. Virol. 88:1960-1966, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  7. Integrating uncertainty propagation in GNSS radio occultation retrieval: from excess phase to atmospheric bending angle profiles

    Directory of Open Access Journals (Sweden)

    J. Schwarz

    2018-05-01

    Full Text Available Global Navigation Satellite System (GNSS radio occultation (RO observations are highly accurate, long-term stable data sets and are globally available as a continuous record from 2001. Essential climate variables for the thermodynamic state of the free atmosphere – such as pressure, temperature, and tropospheric water vapor profiles (involving background information – can be derived from these records, which therefore have the potential to serve as climate benchmark data. However, to exploit this potential, atmospheric profile retrievals need to be very accurate and the remaining uncertainties quantified and traced throughout the retrieval chain from raw observations to essential climate variables. The new Reference Occultation Processing System (rOPS at the Wegener Center aims to deliver such an accurate RO retrieval chain with integrated uncertainty propagation. Here we introduce and demonstrate the algorithms implemented in the rOPS for uncertainty propagation from excess phase to atmospheric bending angle profiles, for estimated systematic and random uncertainties, including vertical error correlations and resolution estimates. We estimated systematic uncertainty profiles with the same operators as used for the basic state profiles retrieval. The random uncertainty is traced through covariance propagation and validated using Monte Carlo ensemble methods. The algorithm performance is demonstrated using test day ensembles of simulated data as well as real RO event data from the satellite missions CHAllenging Minisatellite Payload (CHAMP; Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC; and Meteorological Operational Satellite A (MetOp. The results of the Monte Carlo validation show that our covariance propagation delivers correct uncertainty quantification from excess phase to bending angle profiles. The results from the real RO event ensembles demonstrate that the new uncertainty estimation chain performs

  8. A vast increase in the use of CT scans for investigating occult hip fractures

    International Nuclear Information System (INIS)

    Jordan, Robert; Dickenson, Edward; Westacott, Daniel; Baraza, Njalalle; Srinivasan, Kuntrapka

    2013-01-01

    Background: Early diagnosis in neck of femur fractures has been shown to improve outcome. The National Institute for Clinical Excellence recommends if an occult hip fracture is suspected then an MRI should be performed and if not available within 24 h a CT should be considered. At our centre, emergency MRI is rarely available and so CT is commonly used. Objectives: Our study aims to analyse the trends in CT use over a five year period for the diagnosis of neck of femur fractures. Methods: Both the number of patients with a hip fracture and those undergoing a CT hip to diagnose an occult injury were identified across two district general hospitals between 2006–2007 and 2010–2011. The time from initial radiograph to CT and initial radiograph to operation were calculated. Results: In 2006–2007, of 547 hip fractures, 20 CT hips were performed and 6 reported as a fractured neck of femur (30%). In 2010–2011, of 499 hip fractures, 239 CT hips were performed and 65 fractures were recognised (27%). The mean time from radiograph until CT scan was 2.0 days in 2007 and 3.2 days in 2011, which was a statistically significant difference (p < 0.001). For those diagnosed using a CT scan the mean time from admission X-ray to surgery was 1.2 days in 2007 and 3.6 days in 2011. Conclusion: Clinicians are becoming increasingly reliant on CT for the diagnosis of hip fractures with our data suggesting further imaging is one factor that can delay time to diagnosis and theatre

  9. A vast increase in the use of CT scans for investigating occult hip fractures

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, Robert, E-mail: Robert.jordan@doctors.org.uk; Dickenson, Edward, E-mail: edwarddickenson@doctors.org.uk; Westacott, Daniel, E-mail: dan_westacott@hotmail.com; Baraza, Njalalle, E-mail: njaleb@Doctors.Org.Uk; Srinivasan, Kuntrapka, E-mail: bijusri@Yahoo.Co.Uk

    2013-08-15

    Background: Early diagnosis in neck of femur fractures has been shown to improve outcome. The National Institute for Clinical Excellence recommends if an occult hip fracture is suspected then an MRI should be performed and if not available within 24 h a CT should be considered. At our centre, emergency MRI is rarely available and so CT is commonly used. Objectives: Our study aims to analyse the trends in CT use over a five year period for the diagnosis of neck of femur fractures. Methods: Both the number of patients with a hip fracture and those undergoing a CT hip to diagnose an occult injury were identified across two district general hospitals between 2006–2007 and 2010–2011. The time from initial radiograph to CT and initial radiograph to operation were calculated. Results: In 2006–2007, of 547 hip fractures, 20 CT hips were performed and 6 reported as a fractured neck of femur (30%). In 2010–2011, of 499 hip fractures, 239 CT hips were performed and 65 fractures were recognised (27%). The mean time from radiograph until CT scan was 2.0 days in 2007 and 3.2 days in 2011, which was a statistically significant difference (p < 0.001). For those diagnosed using a CT scan the mean time from admission X-ray to surgery was 1.2 days in 2007 and 3.6 days in 2011. Conclusion: Clinicians are becoming increasingly reliant on CT for the diagnosis of hip fractures with our data suggesting further imaging is one factor that can delay time to diagnosis and theatre.

  10. Integrating uncertainty propagation in GNSS radio occultation retrieval: from excess phase to atmospheric bending angle profiles

    Science.gov (United States)

    Schwarz, Jakob; Kirchengast, Gottfried; Schwaerz, Marc

    2018-05-01

    Global Navigation Satellite System (GNSS) radio occultation (RO) observations are highly accurate, long-term stable data sets and are globally available as a continuous record from 2001. Essential climate variables for the thermodynamic state of the free atmosphere - such as pressure, temperature, and tropospheric water vapor profiles (involving background information) - can be derived from these records, which therefore have the potential to serve as climate benchmark data. However, to exploit this potential, atmospheric profile retrievals need to be very accurate and the remaining uncertainties quantified and traced throughout the retrieval chain from raw observations to essential climate variables. The new Reference Occultation Processing System (rOPS) at the Wegener Center aims to deliver such an accurate RO retrieval chain with integrated uncertainty propagation. Here we introduce and demonstrate the algorithms implemented in the rOPS for uncertainty propagation from excess phase to atmospheric bending angle profiles, for estimated systematic and random uncertainties, including vertical error correlations and resolution estimates. We estimated systematic uncertainty profiles with the same operators as used for the basic state profiles retrieval. The random uncertainty is traced through covariance propagation and validated using Monte Carlo ensemble methods. The algorithm performance is demonstrated using test day ensembles of simulated data as well as real RO event data from the satellite missions CHAllenging Minisatellite Payload (CHAMP); Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC); and Meteorological Operational Satellite A (MetOp). The results of the Monte Carlo validation show that our covariance propagation delivers correct uncertainty quantification from excess phase to bending angle profiles. The results from the real RO event ensembles demonstrate that the new uncertainty estimation chain performs robustly. Together

  11. Effect of small-scale ionospheric variability on GNSS radio occultation data quality

    Science.gov (United States)

    Verkhoglyadova, O. P.; Mannucci, A. J.; Ao, C. O.; Iijima, B. A.; Kursinski, E. R.

    2015-09-01

    Global Navigation Satellite Systems (GNSS) radio occultation (RO) measurements are sensitive to thin ionization layers and small-scale ionosphere structures. To evaluate error bounds and possible biases in atmospheric retrievals, we characterized ionospheric irregularities encountered in the affected profiles by analyzing the L1 signal-to-noise ratio (SNR) variability at E layer altitudes (from 90 km to 130 km). New metrics to analyze statistical effects of small-scale ionospheric irregularities on refractivity retrievals are proposed. We analyzed refractivity (N) retrievals with Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) ROs in 2011. Using refractivity from European Centre for Medium-Range Weather Forecasts (ECMWF) analysis (NECMWF) as the reference data set, we studied statistical properties of the fractional refractivity bias (ΔN) defined by the difference (NECMWF - N)/NECMWF and averaged in the altitude range from 20 to 25 km for each individual profile. We found that (1) persistently larger variability of the L1 SNR as measured by the interquartile range (IQR) existed when the occultation tangent point was in the 90 km to 110 km altitude range than at higher E layer altitudes; (2) the upper limits on the fractional refractivity bias for COSMIC ROs are 0.06% (for daytime local time), 0.1% (for nighttime local time), and ~0.01% (for all local times); (3) distributions of ΔN are non-Gaussian (leptokurtic); (4) latitudinal distributions of small and large ΔN for different levels of ionospheric variability show large tails (NECMWF > N) occurring around the Himalaya and the Andes regions, which are possibly due to biases in ECMWF analysis. We conclude that the refractivity bias due to small-scale irregularities is small below 25 km altitude and can be neglected.

  12. Stress Management: Job Stress

    Science.gov (United States)

    Healthy Lifestyle Stress management Job stress can be all-consuming — but it doesn't have to be. Address your triggers, keep perspective and ... stress triggers, it's often helpful to improve time management skills — especially if you tend to feel overwhelmed ...

  13. Diagnosis of an isolated occult fracture of the posterior margin of the tibia with the SPECT/CT; Diagnostic d'une fracture occulte isolee de la marge posterieure du tibia par la TEMP-TDM

    Energy Technology Data Exchange (ETDEWEB)

    Bourdon, A.; Granier, P.; Mourad, M. [Centre Hospitalier de Carcassonne Antoine-Gayraud, Service de Medecine Nucleaire, 11 - Carcassonne (France)

    2007-12-15

    We report the case of a 56-year-old woman, investigated for pains of the right ankle related to a trauma of an unspecified mechanism. The radiographic assessment was negative. The {sup 99m}Tc-HDP 3-phase bone scintigraphy highlighted, on the blood pool and the delayed images, a located lesion on the right ankle. The single photon emission computerized tomography guided by computerized tomography (SPECT-CT) showed a focused uptake on the posterior margin of the right tibia and a sharp lucent line within the tomo-scintigraphy spot of uptake. The diagnosis accepted was an isolated occult fracture of the posterior margin of the right tibia. The contribution of the {sup 99m}Tc-HDP 3-phase bone scintigraphy combined with the SPECT-CT in the diagnosis of the occult fractures is discussed. (N.C.)

  14. Childhood Stress

    Science.gov (United States)

    ... Safe Videos for Educators Search English Español Childhood Stress KidsHealth / For Parents / Childhood Stress What's in this ... and feel stress to some degree. Sources of Stress Stress is a function of the demands placed ...

  15. Immunochemical faecal occult blood tests have superior stability and analytical performance characteristics over guaiac-based tests in a controlled in vitro study.

    LENUS (Irish Health Repository)

    Lee, Chun Seng

    2011-06-01

    The aims of this study were (1) to determine the measurement accuracy of a widely used guaiac faecal occult blood test (gFOBT) compared with an immunochemical faecal occult blood test (iFOBT) during in vitro studies, including their analytical stability over time at ambient temperature and at 4°C; and (2) to compare analytical imprecision and other characteristics between two commercially available iFOBT methods.

  16. The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

    International Nuclear Information System (INIS)

    Bandopadhayay, Pratiti; Thomas, David M; Algar, Elizabeth; Ekert, Paul G; Jabbour, Anissa M; Riffkin, Christopher; Salmanidis, Marika; Gordon, Lavinia; Popovski, Dean; Rigby, Lin; Ashley, David M; Watkins, David N

    2013-01-01

    Desmoplastic small round cell tumor (DSRCT) is characterized by the presence of a fusion protein EWS/WT1, arising from the t (11;22) (p13;q12) translocation. Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/WT1-KTS and EWS/WT1 + KTS. We over-expressed both EWS/WT1 variants in murine embryonic fibroblasts (MEFs) of wild-type, p53 +/- and p53 -/- backgrounds and measured effects on cell-proliferation, anchorage-independent growth, clonogenicity after serum withdrawal, and sensitivity to cytotoxic drugs and gamma irradiation in comparison to control cells. We examined gene expression profiles in cells expressing EWS/WT1. Finally we validated our key findings in a small series of DSRCT. Neither isoform of EWS/WT1 was sufficient to transform wild-type MEFs however the oncogenic potential of both was unmasked by p53 loss. Expression of EWS/WT1 in MEFs lacking at least one allele of p53 enhanced cell-proliferation, clonogenic survival and anchorage-independent growth. EWS/WT1 expression in wild-type MEFs conferred resistance to cell-cycle arrest after irradiation and daunorubicin induced apoptosis. We show DSRCT commonly have nuclear localization of p53, and copy-number amplification of MDM2/MDMX. Expression of either isoform of EWS/WT1 induced characteristic mRNA expression profiles. Gene-set enrichment analysis demonstrated enrichment of WNT pathway signatures in MEFs expressing EWS/WT1 + KTS. Wnt-activation was validated in cell lines with over-expression of EWS/WT1 and in DSRCT. In conclusion, we show both isoforms of EWS/WT1 have oncogenic potential in MEFs with loss of p53. In addition we provide the first link between EWS/WT1 and Wnt-pathway signaling. These data provide novel insights into the function of the EWS/WT1 fusion protein which characterize DSRCT

  17. Are you afraid of the dark? Notes on the psychology of belief in histories of science and the occult.

    Science.gov (United States)

    Sommer, Andreas

    2016-04-02

    The popular view of the inherent conflict between science and the occult has been rendered obsolete by recent advances in the history of science. Yet, these historiographical revisions have gone unnoticed in the public understanding of science and public education at large. Particularly, reconstructions of the formation of modern psychology and its links to psychical research can show that the standard view of the latter as motivated by metaphysical bias fails to stand up to scrutiny. After highlighting certain basic methodological maxims shared by psychotherapists and historians, I will try to counterbalance simplistic claims of a 'need to believe' as a precondition of scientific open-mindedness regarding the occurrence of parapsychological phenomena by discussing instances revealing a presumably widespread 'will to disbelieve' in the occult. I shall argue that generalized psychological explanations are only helpful in our understanding of history if we apply them in a symmetrical manner.

  18. [Occult medicine in the 20th century: pharmacotherapy by Demeter Georgievitz-Weitzer, known as Surya (1873 - 1949)].

    Science.gov (United States)

    Helmstädter, Axel

    2011-01-01

    Demeter Georgievitz-Weitzer (1873-1949), called "Surya", Sanskrit for "sun", was an important representative of medical occultism in the first half of the 20th century. He worked as a journal editor and published a 13-volume book series about occult medicine, mainly written by himself. His hypotheses were closely related to the "Lebensreform" movement around 1900. Regarding diagnostics, he relied on astrology, cheiromancy, and clairvoyance, while therapeutics were dominated by diet and spagyric remedies according to Cesare Mattei (1809-1896) and Carl-Friedrich Zimpel (1801-1879). In his later years, he developed his own healing system, initially comprising eight, later only two preparations. Surya remedies were commercially available until the end of the 20th century,

  19. Are you afraid of the dark? Notes on the psychology of belief in histories of science and the occult

    Science.gov (United States)

    Sommer, Andreas

    2016-01-01

    Abstract The popular view of the inherent conflict between science and the occult has been rendered obsolete by recent advances in the history of science. Yet, these historiographical revisions have gone unnoticed in the public understanding of science and public education at large. Particularly, reconstructions of the formation of modern psychology and its links to psychical research can show that the standard view of the latter as motivated by metaphysical bias fails to stand up to scrutiny. After highlighting certain basic methodological maxims shared by psychotherapists and historians, I will try to counterbalance simplistic claims of a ‘need to believe’ as a precondition of scientific open-mindedness regarding the occurrence of parapsychological phenomena by discussing instances revealing a presumably widespread ‘will to disbelieve’ in the occult. I shall argue that generalized psychological explanations are only helpful in our understanding of history if we apply them in a symmetrical manner. PMID:27226762

  20. Diagnosis of an isolated occult fracture of the posterior margin of the tibia with the SPECT/CT

    International Nuclear Information System (INIS)

    Bourdon, A.; Granier, P.; Mourad, M.

    2007-01-01

    We report the case of a 56-year-old woman, investigated for pains of the right ankle related to a trauma of an unspecified mechanism. The radiographic assessment was negative. The 99m Tc-HDP 3-phase bone scintigraphy highlighted, on the blood pool and the delayed images, a located lesion on the right ankle. The single photon emission computerized tomography guided by computerized tomography (SPECT-CT) showed a focused uptake on the posterior margin of the right tibia and a sharp lucent line within the tomo-scintigraphy spot of uptake. The diagnosis accepted was an isolated occult fracture of the posterior margin of the right tibia. The contribution of the 99m Tc-HDP 3-phase bone scintigraphy combined with the SPECT-CT in the diagnosis of the occult fractures is discussed. (N.C.)

  1. Patient experience of CT colonography and colonoscopy after fecal occult blood test in a national screening programme

    OpenAIRE

    Plumb, Andrew A.; Ghanouni, Alex; Rees, Colin J.; Hewitson, Paul; Nickerson, Claire; Wright, Suzanne; Taylor, Stuart A.; Halligan, Steve; von Wagner, Christian

    2016-01-01

    Objective To investigate patient experience of CT colonography (CTC) and colonoscopy in a national screening programme. Methods Retrospective analysis of patient experience postal questionnaires. We included screenees from a fecal occult blood test (FOBt) based screening programme, where CTC was performed when colonoscopy was incomplete or deemed unsuitable. We analyzed questionnaire responses concerning communication of test risks, test-related discomfort and post-test pain, as well as compl...

  2. Patient experience of CT colonography and colonoscopy after fecal occult blood test in a national screening programme

    OpenAIRE

    Plumb, A. A.; Ghanouni, A.; Rees, C. J.; Hewitson, P.; Nickerson, C.; Wright, S.; Taylor, S. A.; Halligan, S.; von Wagner, C.

    2017-01-01

    OBJECTIVE: To investigate patient experience of CT colonography (CTC) and colonoscopy in a national screening programme. METHODS: Retrospective analysis of patient experience postal questionnaires. We included screenees from a fecal occult blood test (FOBt) based screening programme, where CTC was performed when colonoscopy was incomplete or deemed unsuitable. We analyzed questionnaire responses concerning communication of test risks, test-related discomfort and post-test pain, as well as com...

  3. Ultrasound Diagnosis of Either an Occult or Missed Fracture of an Extremity in Pediatric-Aged Children

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Kil Ho [Yeungnam University, Daegu (Korea, Republic of); Lee, Sung Moon [Keimyung University Dongsan Hospital, Daegu (Korea, Republic of); Lee, Young Hwan [Daegu Catholic University, Daegu (Korea, Republic of); Suh, Kyung Jin [Dongkuk University, Kyungju (Korea, Republic of)

    2010-02-15

    To report and assess the usefulness of ultrasound (US) findings for occult fractures of growing bones. For six years, US scans were performed in children younger than 15 years who were referred with trauma-related local pain and swelling of the extremities. As a routine US examination, the soft tissue, bones, and adjacent joints were examined in the area of discomfort, in addition to the asymptomatic contralateral extremity for comparison. Twenty-five occult fractures in 25 children (age range, five months-15 years; average age, 7.7 years) were confirmed by initial and follow-up radiograms, additional imaging studies, and clinical observation longer than three weeks. The most common site of occult fractures was the elbow (n = 9, 36%), followed by the knee (n = 7, 28%), ischium (n = 4, 16%), distal fibula (n = 3, 12%), proximal femur (n = 1, 4%), and humeral shaft (n = 1, 4%). On the retrograde review of the routine radiographs, 13 out of the 25 cases showed no bone abnormalities except for various soft tissue swelling. For the US findings, cortical discontinuity (direct sign of a fracture) was clearly visualized in 23 cases (92%) and was questionable in two (8%). As auxiliary US findings (indirect signs of a fracture), step-off deformities, tiny avulsed bone fragments, double-line appearance of cortical margins, and diffuse irregularity of the bone surfaces were identified. Performing US for soft tissue and bone surfaces with pain and swelling, with or without trauma history in the extremities, is important for diagnosing occult or missed fractures of immature bones in pediatric-aged children.

  4. Occult Radiographically Evident Port-Site Hernia After Robot-Assisted Urologic Surgery: Incidence and Risk Factors.

    Science.gov (United States)

    Christie, Matthew C; Manger, Jules P; Khiyami, Abdulaziz M; Ornan, Afshan A; Wheeler, Karen M; Schenkman, Noah S

    2016-01-01

    Laparoscopic trocar-site hernias (TSH) are rare, with a reported incidence of 1% or less. The incidence of occult radiographically evident hernias has not been described after robot-assisted urologic surgery. We evaluated the incidence and risk factors of this problem. A single-institution retrospective review of robot-assisted urologic surgery was performed from April 2009 to December 2012. Patients with preoperative and postoperative CT were included for analysis. Imaging was reviewed by two radiologists and one urologist. One hundred four cases were identified, including 60 partial nephrectomy, 38 prostatectomy, and 6 cystectomy. Mean age was 58 years and mean body mass index (BMI) was 29 kg/m(2). The cohort was 77% male. Ten total hernias were identified by CT in 8 patients, 2 of which were clinically evident hernias. Excluding these two hernias, occult port-site hernias were identified radiographically in seven patients. Per-patient incidence of occult TSH was 6.7% (7/104), and per-port incidence was 1.4% (8/564). All hernias were midline and 30% contained bowel. Eight of the 10 occurred at 12 mm sites (p = 0.0065) and 3 of the 10 occurred at extended incisions. Age, gender, BMI, smoking status, diabetes mellitus, immunosuppressive drug therapy, ASA score, procedure, blood loss, prior abdominal surgery, and history of hernia were not significant risk factors. Specimen size >40 g (p = 0.024) and wound infection (p = 0.0052) were significant risk factors. While the incidence of clinically evident port-site hernia remains low in robot-assisted urologic surgery, the incidence of CT-detected occult hernia was 6.7% in this series. These occurred most often in sites extended for specimen extraction and at larger port sites. This suggests more attention should be paid to fascial closure at these sites.

  5. HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors

    Directory of Open Access Journals (Sweden)

    J.S.F. Pereira

    2006-04-01

    Full Text Available Anti-HBc positivity is a frequent cause of donation rejection at blood banks. Hepatitis B virus (HBV infection may also occur in HBsAg-negative patients, a situation denoted occult infection. Similarly, very low levels of HBV-DNA have also been found in the sera of patients with chronic hepatitis C virus (HCV infection, even in the absence of serum HBsAg. Initially we searched for HBV-DNA in serum of 100 blood donors and 50 HCV-infected patients who were HBsAg negative/anti-HBc positive by nested-PCR and by an HBV monitor commercial test for HBV-DNA. Anti-HBs seroconversion rates were measured in 100 blood donors and in 22 patients with chronic HCV infection after HBV vaccination to determine if the HBV vaccination could eliminate an occult HBV infection in these individuals. Occult HBV infection was detected in proportionally fewer blood donors (6/100 = 6% than chronic hepatitis C patients (12/50 = 24% (P 0.05. All subjects who were HBV-DNA(+ before the first dose of HBV vaccine (D1, became HBV-DNA(- after D1, D2, and D3. Among 22 HCV-positive patients, 10 HBV-DNA(+ and 12 HBV-DNA(-, seroconversion was observed in 9/10 (90% HBV-DNA(+ and in 9/12 (75% HBV-DNA(- subjects (P > 0.05. The disappearance of HBV-DNA in the majority of vaccinated patients suggests that residual HBV can be eliminated in patients with occult infection.

  6. Are you afraid of the dark? Notes on the psychology of belief in histories of science and the occult

    OpenAIRE

    Sommer, Andreas

    2016-01-01

    This is the final version of the article. It first appeared from Taylor & Francis via https://doi.org/ 10.1080/13642537.2016.1170062 The popular view of the inherent conflict between science and the occult has been rendered obsolete by recent advances in the history of science. Yet, these historiographical revisions have gone unnoticed in the public understanding of science and public education at large. Particularly reconstructions of the formation of modern psychology and its links to...

  7. Sensitivity of airborne radio occultation to tropospheric properties over ocean and land

    Directory of Open Access Journals (Sweden)

    F. Xie

    2018-02-01

    Full Text Available Airborne radio occultation (ARO measurements collected during a ferry flight at the end of the PRE-Depression Investigation of Cloud-systems in the Tropics (PREDICT field campaign from the Virgin Islands to Colorado are analyzed. The large contrast in atmospheric conditions along the flight path from the warm and moist Caribbean Sea to the much drier and cooler continental conditions provides a unique opportunity to address the sensitivity of ARO measurements to the tropospheric temperature and moisture changes. This long flight at nearly constant altitude (∼ 13 km provided an optimal configuration for simultaneous high-quality ARO measurements from two high-gain side-looking antennas, as well as one relatively lower gain zenith (top antenna. The omnidirectional top antenna has the advantage of tracking robustly more occulting satellites in all direction as compared to the limited-azimuth tracking of the side-looking antennas. Two well-adapted radio-holographic bending angle retrieval methods, full-spectrum inversion (FSI and phase matching (PM, were compared with the standard geometric-optics (GO retrieval method. Comparison of the ARO retrievals from the top antenna with the near-coincident ECMWF reanalysis-interim (ERA-I profiles shows only a small root-mean-square (RMS refractivity difference of ∼ 0.3 % in the drier upper troposphere from ∼ 5 to ∼ 11.5 km over both land and ocean. Both the FSI and PM methods improve the ARO retrievals in the moist lower troposphere and reduce the negative bias found in the GO retrieval due to atmospheric multipath. In the lowest layer of the troposphere, the ARO refractivity derived using FSI shows a negative bias of about −2 %. The increase of the refractivity bias occurs below 5 km over the ocean and below 3.5 km over land, corresponding to the approximate altitude of large vertical moisture gradients above the ocean and land surface, respectively. In comparisons to

  8. Assessment of occult cervical lymph node metastasis in primary squamous cell carcinoma of the head and neck by computed tomography

    International Nuclear Information System (INIS)

    Shakil, U.

    2015-01-01

    To determine the frequency of occult (node negative) cervical lymph node metastasis in primary head and neck squamous cell carcinoma, using contrast enhanced computed tomography (CT). Study Design: Cross sectional descriptive study. Place and Duration of Study: Study was conducted in Department of Radiology, Combined Military Hospital Rawalpindi. Duration of the study was 06 months i.e. from 19th February 2011 to 19th August 2011. Patients and Methods: A total of 141 cases, fulfilling the inclusion criteria, reporting to the radiology department, were included in the study after seeking written informed consent. All patients underwent contrast enhanced CT scan of the neck from base of skull to root of neck using Asteion Whole Body X-ray CT Scanner (Model TSX-021A). Images were evaluated for the presence or absence of cervical lymph node metastasis according to the cervical lymph node metastatic criteria at each level of the neck. Results: Of the 141 patients with clinically no head and neck squamous cell carcinoma, 45.4% were found to have lymph node metastases. Frequency of occult metastases in squamous cell carcinoma of oral cavity was 47.6%, oropharynx 23.5%, larynx 33.3% and hypopharynx 78.6%. Conclusion: In clinically node negative neck, the risk of lymph node metastases is significantly high in patients of head and neck squamous cell carcinoma in our population. All patients presenting with node negative neck should undergo CT scans for early detection of occult metastasis. (author)

  9. The use of 111In-labelled platelets for scintigraphic localization of gastrointestinal bleeding with special reference to occult bleeding

    International Nuclear Information System (INIS)

    Gjerloeff Schmidt, K.; Waever Rasmussen, J.; Grove, O.; Andersen, D.

    1986-01-01

    Gamma-camera imaging of the abdomen after injection of autologous 111 In-labelled platelets was applied for localization of gastrointestinal bleeding in a study of 22 patients. In 15 studies showing scintigraphic signs of bleeding, the clinical presentation included occult bleeding in 6, melaena in 4, and bloody stools in 5 patients. Scintigraphy could be done repeatedly for up to 1 week after a single tracer injection. The time interval between the injection and scintigraphic visualization of bleeding ranged from 10 min to 68 h, being longest in cases of occult bleeding. In most cases the scintigraphic findings were supported by other diagnostic modalities, including surgical removal of presumed sources of bleeding. In seven studies without scintigraphic signs of bleeding, a probable source of bleeding was identified by other means in one patient. The 111 In-platelet method seems to be a promising method for localization of gastrointestinal bleeding which may prove particularly useful in cases of occult or recurrent bleeding

  10. Right upper-quadrant pain in a patient with drug abuse, secondary syphilis and occult hepatitis B virus.

    Science.gov (United States)

    Fielding, Cory M; Angulo, Paul

    2014-01-01

    To describe the etiology of hepatitis and identify occult hepatitis B virus (HBV) infection. A 40-year-old man presented with severe abdominal pain and jaundice, a history of acute HBV infection that had cleared as well as the use of acetaminophen, methamphetamine, buprenorphine and marijuana. He admitted to having had unprotected sex with multiple partners of both genders. A thorough skin examination revealed papulosquamous lesions on his penis, scrotum, upper and lower extremities and feet. Transaminases and bilirubin were elevated. His rapid plasma reagin was reactive, and hepatitis serologies showed occult HBV. Liver biopsy showed severe hepatitis, but the stains for hepatitis B surface antigen and hepatitis B core antigen were negative. The pathological findings were highly indicative of drug-induced hepatitis without evidence of chronic hepatitis, reactivation of HBV or syphilitic hepatitis. With supportive management and abstinence from drugs, his condition improved. This case describes a patient with multiple potential causes for hepatitis and highlights the importance of obtaining a detailed social history. Further, one should consider the presence of occult HBV and recognize the serologic pattern. © 2014 S. Karger AG, Basel.

  11. The “communication line” suggests occult posterior malleolar fracture associated with a spiral tibial shaft fracture

    International Nuclear Information System (INIS)

    Hou Zhiyong; Zhang Liping; Zhang Qi; Yao Shuangquan; Pan Jinshe; Irgit, Kaan; Zhang Yingze

    2012-01-01

    Objectives: To demonstrate radiographical characteristics of the relationship between distal spiral tibial shaft fractures and associated occult posterior malleolar fractures (PMF) that confirmed by CT and MRI. Materials and methods: X-rays for a ninety-six patients with spiral tibia fracture and associated PMF were reviewed. All patients additionally had an ankle CT. Patients with a negative CT scans underwent an ankle MRI. Radiographic observations included fracture location, characteristics, and a presence of a fracture line between the two injuries. Results: The spiral tibia fracture line was contiguous with PMF in 89 of 96 cases after evaluation with the CT and MRI. The line connecting the two injuries, which occurs between the medial inferior apex of the spiral tibia fracture line and the posterior superior apex of the PMF was identified as the “communication line”. In 47 of the 89 conjunction fractures, the “communication line” was detectable preoperatively and in 12 cases postoperatively by anteroposterior radiograph. By using the CT and MRI scans, we found that no “communication line” was present in only 7 cases. Conclusion: It is important to understand the nature of the association between distal spiral tibial shaft fractures and occult posterior malleolar fractures for optimal stabilization of the fracture and for appropriate rehabilitation. The “communication line” is a useful diagnostic clue for early recognition the occult PMF and alerts a closer evaluation of the lateral view and further CT examination.

  12. A game of two discs: a case of non-contiguous and occult cervical spine injury in a rugby player.

    Science.gov (United States)

    O'Sullivan, Michael D; Piggot, Robert; Jaddan, Mutaz; McCabe, John P

    2016-03-14

    The aim of this case report was to highlight the application of magnetic resonance imaging (MRI) in elucidating serious and occult injuries in a single case of hyperflextion injury of a patient cervical spine (C-Spine). A chart and radiology review was performed to establish the sequence of care and how the results of imaging studies influenced the clinical management in this trauma case. Plain radiographs and computed tomography (CT) imaging modalities of the C-Spine revealed bilateral C4/C5 facetal subluxation with no obvious fractures; however, the MR imaging of the C-Spine revealed a non-contiguous and occult injury to C6/C7 disc with a posterior annular tear and associated disc extrusion. This altered the operative intervention that was initially planned. MR imaging proved an invaluable diagnostic addition in this particular case of cervical trauma in a rugby player following a hyperflextion injury, by revealing a serious non-contiguous and occult injury of the C-Spine. Published by Oxford University Press and JSCR Publishing Ltd. All rights reserved. © The Author 2016.

  13. Atmospheric deposition of heavy metals due to dry, wet and occult deposition at the altitude profile Achenkirch

    International Nuclear Information System (INIS)

    Stopper, S.

    2001-12-01

    The goal of this work was to determine the height dependence of the three types of deposition throughout a one year time period to be able to get information about their elevational and seasonal behavior. In the time period from October 1998 to November 1999 measurements of Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, V and Zn in aerosol, rain and cloud water were conducted in the Achenkirch-Valley in Tyrol, Austria. Afterwards the dry and occult deposition were modeled. The estimated annual inputs of metals at the two measurement sites Christlumkopf (1758 m a.s.l.) Mueeggerkoel (940 m a.s.l.) and the limits of the national law for protection of forest are shown. The measured depositions at both sites were far below the legal regulations. Due to the much higher occult deposition ratio at the top of the mountain the total annual input at the Christlumkopf was higher than at the Mueeggerkoel. This indicates the potential importance of occult deposition. (author)

  14. Occult pneumothorax in blunt trauma: is there a need for tube thoracostomy?

    Science.gov (United States)

    Zhang, M; Teo, L T; Goh, M H; Leow, J; Go, K T S

    2016-12-01

    Occult pneumothorax (OPTX) is defined as air within the pleural cavity that is undetectable on normal chest X-rays, but identifiable on computed tomography. Currently, consensus is divided between tube thoracostomy and conservative management for OPTX. The aim of this retrospective study is to determine whether OPTX can be managed conservatively and whether any adverse events occur under conservative management. Data on all trauma patients from 1 Jan 2010 to 31 December 2012 were obtained from our hospital's trauma registry. All patients with occult pneumothorax who had chest X-ray (CXR) and any CT scan visualizing the thorax were included. The exclusion criteria included those with penetrating wounds; CXR showing pneumothorax, hemothorax, or hemopneumothorax; those with prophylactic chest tube insertion before CT; and those with no CT diagnosis of OPTX. The complications of these patients were analyzed to determine if tube thoracostomy is necessary for OPTX and whether not inserting it would alter the outcome significantly. A total of 1564 cases were reviewed and 83 patients were included. Of these 83 patients, 35 (42.2 %) had tube thoracostomy after OPTX detection and 48 (57.8 %) were observed initially. Patients who had tube thoracostomy had similar ISS compared to those without (median ISS 17 vs. 18.5, p = 0.436). Out of the 48 patients who did not have tube thoracostomy on detection of an OPTX, 4 (8.3 %) had complications. In the group of 35 patients who had tube thoracostomy on detection of an OPTX, 7 (20 %) had complications. Of the 83 patients, a total of 12 patients had IPPV, of which 7 (58.3 %) had tube thoracostomy and 5 (41.7 %) did not. Patients who had tube thoracostomy under our care have a statistically significant likelihood of experiencing any complication compared to those without tube thoracostomy (odds ratio 9.92. The median length of stay was also longer (13 days) in those who had tube thoracostomy compared to those without (5

  15. Inversion, error analysis, and validation of GPS/MET occultation data

    Directory of Open Access Journals (Sweden)

    A. K. Steiner

    Full Text Available The global positioning system meteorology (GPS/MET experiment was the first practical demonstration of global navigation satellite system (GNSS-based active limb sounding employing the radio occultation technique. This method measures, as principal observable and with millimetric accuracy, the excess phase path (relative to propagation in vacuum of GNSS-transmitted radio waves caused by refraction during passage through the Earth's neutral atmosphere and ionosphere in limb geometry. It shows great potential utility for weather and climate system studies in providing an unique combination of global coverage, high vertical resolution and accuracy, long-term stability, and all-weather capability. We first describe our GPS/MET data processing scheme from excess phases via bending angles to the neutral atmospheric parameters refractivity, density, pressure and temperature. Special emphasis is given to ionospheric correction methodology and the inversion of bending angles to refractivities, where we introduce a matrix inversion technique (instead of the usual integral inversion. The matrix technique is shown to lead to identical results as integral inversion but is more directly extendable to inversion by optimal estimation. The quality of GPS/MET-derived profiles is analyzed with an error estimation analysis employing a Monte Carlo technique. We consider statistical errors together with systematic errors due to upper-boundary initialization of the retrieval by a priori bending angles. Perfect initialization and properly smoothed statistical errors allow for better than 1 K temperature retrieval accuracy up to the stratopause. No initialization and statistical errors yield better than 1 K accuracy up to 30 km but less than 3 K accuracy above 40 km. Given imperfect initialization, biases >2 K propagate down to below 30 km height in unfavorable realistic cases. Furthermore, results of a statistical validation of GPS/MET profiles through comparison

  16. NEOCE: a new external occulting coronagraph experiment for ultimate observations of the chromosphere, corona and interface

    Science.gov (United States)

    Damé, Luc; Fineschi, Silvano; Kuzin, Sergey; Von Fay-Siebenburgen, Erdélyi Robert

    Several ground facilities and space missions are currently dedicated to the study of the Sun at high resolution and of the solar corona in particular. However, and despite significant progress with the advent of space missions and UV, EUV and XUV direct observations of the hot chromosphere and million-degrees coronal plasma, much is yet to be achieved in the understanding of these high temperatures, fine dynamic dissipative structures and of the coronal heating in general. Recent missions have shown the definite role of a wide range of waves and of the magnetic field deep in the inner corona, at the chromosphere-corona interface, where dramatic and physically fundamental changes occur. The dynamics of the chromosphere and corona is controlled and governed by the emerging magnetic field. Accordingly, the direct measurement of the chromospheric and coronal magnetic fields is of prime importance. The solar corona consists of many localised loop-like structures or threads with the plasmas brightening and fading independently. The plasma evolution in each thread is believed to be related to the formation of filaments, each one being dynamic, in a non-equilibrium state. The mechanism sustaining this dynamics, oscillations or waves (Alfvén or other magneto-plasma waves), requires both very high-cadence, multi-spectral observations, and high resolution and coronal magnetometry. This is foreseen in the future Space Mission NEOCE (New External Occulting Coronagraph Experiment), the ultimate new generation high-resolution coronagraphic heliospheric mission, to be proposed for ESA M4. NEOCE, an evolution of the HiRISE mission, is ideally placed at the L5 Lagrangian point (for a better follow-up of CMEs), and provides FUV imaging and spectro-imaging, EUV and XUV imaging and spectroscopy, and ultimate coronagraphy by a remote external occulter (two satellites in formation flying 375 m apart minimizing scattered light) allowing to characterize temperature, densities and

  17. Modeling of the Enceladus water vapor jets for interpreting UVIS star and solar occultation observations

    Science.gov (United States)

    Portyankina, Ganna; Esposito, Larry W.; Aye, Klaus-Michael; Hansen, Candice J.

    2015-11-01

    One of the most spectacular discoveries of the Cassini mission is jets emitting from the southern pole of Saturn’s moon Enceladus. The composition of the jets is water vapor and salty ice grains with traces of organic compounds. Jets, merging into a wide plume at a distance, are observed by multiple instruments on Cassini. Recent observations of the visible dust plume by the Cassini Imaging Science Subsystem (ISS) identified as many as 98 jet sources located along “tiger stripes” [Porco et al. 2014]. There is a recent controversy on the question if some of these jets are “optical illusion” caused by geometrical overlap of continuous source eruptions along the “tiger stripes” in the field of view of ISS [Spitale et al. 2015]. The Cassini’s Ultraviolet Imaging Spectrograph (UVIS) observed occultations of several stars and the Sun by the water vapor plume of Enceladus. During the solar occultation separate collimated gas jets were detected inside the background plume [Hansen et al., 2006 and 2011]. These observations directly provide data about water vapor column densities along the line of sight of the UVIS instrument and could help distinguish between the presence of only localized or also continuous sources. We use Monte Carlo simulations and Direct Simulation Monte Carlo (DSMC) to model the plume of Enceladus with multiple (or continuous) jet sources. The models account for molecular collisions, gravitational and Coriolis forces. The models result in the 3-D distribution of water vapor density and surface deposition patterns. Comparison between the simulation results and column densities derived from UVIS observations provide constraints on the physical characteristics of the plume and jets. The specific geometry of the UVIS observations helps to estimate the production rates and velocity distribution of the water molecules emitted by the individual jets.Hansen, C. J. et al., Science 311:1422-1425 (2006); Hansen, C. J. et al, GRL 38:L11202 (2011

  18. Occult pneumothorax in the blunt trauma patient: tube thoracostomy or observation?

    Science.gov (United States)

    Wilson, Heather; Ellsmere, James; Tallon, John; Kirkpatrick, Andrew

    2009-09-01

    The term occult pneumothorax (OP) describes a pneumothorax that is not suspected on the basis of either clinical examination or initial chest radiography, but is subsequently detected on computed tomography (CT) scan. The optimal management of OP in the blunt trauma setting remains controversial. Some physicians favour placement of a thoracostomy tube for patients with OP, particularly those undergoing positive pressure ventilation (PPV), while others favour close observation without chest drainage. This study was conducted both to determine the incidence of OP and to describe its current treatment status in the blunt trauma population at a Canadian tertiary trauma centre. Of interest were the rates of tube thoracostomy vs. observation without chest drainage and their respective outcomes. A retrospective review was conducted of the Nova Scotia Trauma Registry. The data on all consecutive blunt trauma patients between October 1994 and March 2003 was reviewed. Outcome measures evaluated include length of stay, discharge status-dead vs. alive, intervention and time to intervention (tube thoracostomy and its relation to institution of PPV). Direct comparison was made between the OP with tube thoracostomy group and OP without tube thoracostomy group (observation or control group). They were compared in terms of their baseline characteristics and outcome measures. In 1881 consecutive blunt trauma patients over a 102-month period there were 307 pneumothoraces of which 68 were occult. Thirty five patients with OP underwent tube thoracostomy, 33 did not. Twenty nine (82.8%) with tube thoracostomy received positive pressure ventilation (PPV), as did 16 (48.4%) in the observation group. Mean injury severity score (ISS) for tube thoracostomy and observation groups were similar (25.80 and 22.39, p=0.101) whereas length of stay (LOS) was different (17.4 and 10.0 days, p=0.026). Mortality was similar (11.4% and 9.1%). There were no tension pneumothoraces. The natural history of

  19. [Intravitreal Ranibizumab Injection for the Treatment of Occult and Classic CNV in Exsudative AMD].

    Science.gov (United States)

    Maier, M M; Feucht, N; Fegert, C; Fiore, B; Winkler von Mohrenfels, C; Lohmann, C

    2011-02-01

    Double-blind, randomised, placebo-controlled and multicentre studies have proven an increase in visual acuity in one-third of the patients receiving Ranibizumab (0.5 mg) injections, who suffer from exsudative AMD. The purpose of this study was to evaluate the early effects of intravitreal Ranibizumab therapy in patients with mainly occult neovascular AMD in clinical applications. In a retrospective cohort study, 91 eyes with occult and classic neovascular AMD were treated with intravitreal injections of Ranibizumab (0.5 mg) at 30-day intervals. The treatment effects were evaluated according to best corrected visual acuity, optical coherence tomography (OCT) and intraocular pressure at baseline as well as 1, 3 and 6 months after the beginning of therapy. Furthermore, fluorescein angiography (FLA) was performed at baseline as well as 3 and 6 months after therapy. 74 % of the patients lost fewer than 15 letters on the EDTRS-scale 6 months after the beginning of therapy. Visual acuity improved by more than 15 letters in 11 % of the patients. Central retinal thickness, measured by OCT, decreased statistically significantly in each control compared to baseline (1 month: p = 0.045; 3 months: p = 0.001; 6 months: p = 0.006). Leakage and membranes, evaluated in FA, worsened in 31 % of the patients; in 67 % the findings were stable. No increase in intraocular pressure was detected. Intravitreal application of Ranibizumab was safe and well tolerated. In the clinical situation, visual acuity was stabilised in the short term. As opposed to phase-III studies, no improvement in visual acuity could be accomplished. Cental retinal thickness decreased and findings in fluorescein angiography were stable within a 6-month follow-up period. It is necessary to perform monthly controls and proceed with VA- and OCT-based injections in order to maintain the therapeutic effect. Futher clinical evaluations of Ranibizumab will be necessary to evaluate its long-term treatment effects.

  20. Effects of electrotherapy in treatment of neurogenic bladder in children with occult spinal dysraphism

    Directory of Open Access Journals (Sweden)

    Ćirović Dragana

    2009-01-01

    Full Text Available Introduction Neurogenic bladder can develop as a result of various degrees of neurogenic lesion in spina bifida. The degree of bladder dysfunction depends on the level and type of spina bifida. Due to results upon complete diagnostic protocols, treatment options are applied. Objective Comparison of therapy results of patients with occult spinal dysraphism with neurogenic bladder that under-went medicamentous therapy and medicamentous with electrotherapy treatment. Methods We had 49 patients with neurogenic bladder that were treated at the University Children's Hospital in Belgrade in the period 2003-2008. The first group of children received medicamentous therapy and the second group received medicamentous therapy with transcutaneous electric nerve stimulation. In both groups we evaluated 4 symptoms: daily enuresis, enuresis nocturna, urgency and frequency and 4 urodynamic parameters: lower bladder capacity, unstable contractions and residual urine and detrusor sphincter dyssynergia. Follow-up urodynamic evaluation was done after 3, 6 and 12 months respectively. Results Our findings pointed out a high statistical significance of improvement in all evaluated urodynamic parameters of neurogenic bladder (predominantly in bladder capacity in the group of children with combined therapy as well in resolution of symptoms (predominantly enuresis nocturna, urgency and frequency. Conclusion Combined therapy is more efficient in treatment of children with neurogenic bladder. Electrotherapy is non-invasive, easily applicable and has had a significant place in treatment of children with dysfunctional voiding.

  1. STarlight Absorption Reduction through a Survey of Multiple Occulting Galaxies (STARSMOG)

    Science.gov (United States)

    Holwerda, Benne

    2014-10-01

    Dust absorption remains the poorest constrained parameter in both Cosmological distances and multi-wavelength studies of galaxy populations. A galaxy's dust distribution can be measured to great accuracy in the case of an overlapping pair of galaxies, i.e., when a foreground spiral galaxy accidentally overlaps a more distant, preferably elliptical galaxy. We have identified over 300 bona-fide overlapping pairs --well separated in redshift but close on the sky-- in the GAMA spectroscopic survey, taking advantage of its high completeness (98%) on small scales. We propose to map the fine-scale (~50pc) dust structure in these occulting galaxies, using HST/WFC3 SNAP observations. The resulting dust maps will (1) serve as an extinction probability for supernova lightcurve fits in similar type host galaxies, (2) strongly constrain the role of ISM structure in Spectral Energy Distribution models of spiral galaxies, and (3) map the level of ISM turbulence (through the spatial power-spectrum). We ask for SNAP observations with a parent list of 355 targets to ensure a complete and comprehensive coverage of each foreground galaxy mass, radius and inclination. The resulting extinction maps will serve as a library for SNIa measurements, galaxy SED modelling and ISM turbulence measurements.

  2. Radio-guided localization of clinically occult breast lesions (ROLL): a DGH experience

    International Nuclear Information System (INIS)

    Thind, C.R.; Desmond, S.; Harris, O.; Nadeem, R.; Chagla, L.S.; Audisio, R.A.

    2005-01-01

    AIM: Wire-guided localization (WGL) of clinically occult breast lesions is a well established technique. The aim of this study was to evaluate radio-guided localization (ROLL) within the breast screening service of a district general hospital. METHOD: The study group comprised 70 women who underwent ROLL under US and stereotaxis. This required an injection of Technetium-labelled colloidal albumen into the impalpable breast lesion. The women then proceeded to theatre, where localization was achieved with the use of a gamma probe. The lesion was identified by the presence of a high signal, caused by the injected isotope. The results of 70 consecutive cases in which a breast lesion was localized using ROLL were compared with the results of the latest 70 WGLs. RESULTS: All 140 lesions were successfully localized. However, the change in technique from WGL to ROLL offered significant benefits to patients. CONCLUSION: Our study demonstrated that ROLL is a practical and reliable localization technique. It can be implemented in hospital units without using valuable gamma camera time. The cost compares well with WGL. There is an improved cosmetic outcome for patients, and the very small quantity of radioactivity used is safe for both patients and staff

  3. The application of digital tomosynthesis in diagnosis of occult bone fracture

    International Nuclear Information System (INIS)

    Tian Jun; Gong Wuxian; Zhang Dianxing; Tian Ye; Huang Shiting

    2011-01-01

    Objective: To evaluate the digital tomosynthesis in the diagnosis of occult bone fracture. Methods: Both DR and DTS were performed in 135 cases with traumatic-induced pain. All the cases were suspected of bone fractures but with no abnormal findings in DR images. Two radiologists reviewed all the images and diagnosed in consensus. All cases were followed up and the imaging diagnoses were reviewed. Results: Bone fractures or joint dislocations of 61 cases were shown in DTS images but not in DR images, including atlanto-axial fracture and subluxation in 7 cases, articular fracture of limbs in 20 cases, bone fractures of wrist, hand and foot in 11 cases, fractures of cervical, thoracic and lumbar vertebra in 7 cases, fracture of sacrococcyx in 8 cases, fracture of nasal bone in 4 cases, fractures of' Sternum, rib, orbit and mandible in 1 case. Thirty-four cases with bone fractures were determined by using DTS in suspected cases and 17 cases were denied. Both DR and DTS images showed normal findings in 23 cases. Imaging diagnoses of all cases were consistent with the results of follow up. Conclusion: DTS can depict bone fractures especially in the deep and complex bony structures, which may improve the diagnostic accuracy of bone fracture. (authors)

  4. [Occult rupture of the spleen in a patient with infectious mononucleosis].

    Science.gov (United States)

    Bonsignore, A; Grillone, G; Soliera, M; Fiumara, F; Pettinato, M; Calarco, G; Angiò, L G; Licursi, M

    2010-03-01

    Rupture of the spleen can be secondary to abdominal traumas (usually closed trauma) or spontaneous, can interest an organ normal or with morphological alterations secondary to various pathologies. Among the diseases responsible of occult rupture, infectious diseases are the most frequent and, among these, infectious mononucleosis, that is complicated with splenic rupture in 0.5% of the cases, with 30% of mortality. P.M., 16 years old female, admitted with acute abdomen, progressive anaemia and incipient cardiovascular instability, associated with suggestive clinical diagnosis of infectious mononucleosis, confirmed by serological findings and histological examination. Because of the imaging of subcapsular splenic haematoma, probably ruptured and with peritoneal bleeding we opt for emergency laparotomy intraoperative findings allows to splenectomy. Splenic rupture in infectious mononucleosis often presents as left hypochondrial pain, rare in uncomplicated cases; its occurrence in a patient with a recent diagnosis of infectious mononucleosis or with clinical or laboratory features suggestive of acute EBV infection, should always be investigated with an urgent abdominal ultrasound scan or CT. This approach is mandatory when hypochondrial pain is associated with pain referred to the left shoulder (Kehr's sign), peritoneal irritation and haemodynamic instability. Patients with splenic rupture in infectious mononucleosis generally undergo emergency splenectomy.

  5. Bronchoscopic brachytherapy in roentgenologically occult cancer of the trachea and bronchus

    Energy Technology Data Exchange (ETDEWEB)

    Ono, Ryosuke; Hirano, Hiroshi (National Cancer Center, Tokyo (Japan). Central Hospital)

    1994-12-01

    Bronchoscopic brachytherapy is a new technique presently being investigated for the treatment of cancer involving the tracheobronchial tree. This paper reports on the potential application of bronchoscopic brachytherapy to the local treatment of cancer of the respiratory tract. Bronchoscopic brachytherapy was performed on 8 patients with roentgenographically occult lung cancer after biopsies proved malignant lesions of the trachea and bronchus in each case. These patients came to the National Cancer Center Hospital during the period from September 1992 to December 1992. Among these 8 cases of malignant lesions of the trachea and bronchus, 5 malignant lesions of the bronchus were diagnosed by bronchoscopic ultrasonography prior to the bronchoscopic brachytherapy, and these 5 patients have completed at least three courses of this therapy carried out by means of a videobronchoscope. Among the 8 cases of malignant lesions of the trachea and bronchus, complete remission was obtained in 7 cases. Of the 8 patients, the death of one patient was caused by amyotrophic lateral sclerosis, while the remaining 7 patients have survived for 13-15 months (14.1 months on average) to date, without showing recurrence or metastasis. As for the complications involved in this treatment, only a light degree of excessive secretions was observed, and there was no abscess formation in any of the cases. (author).

  6. Bronchoscopic brachytherapy in roentgenologically occult cancer of the trachea and bronchus

    International Nuclear Information System (INIS)

    Ono, Ryosuke; Hirano, Hiroshi

    1994-01-01

    Bronchoscopic brachytherapy is a new technique presently being investigated for the treatment of cancer involving the tracheobronchial tree. This paper reports on the potential application of bronchoscopic brachytherapy to the local treatment of cancer of the respiratory tract. Bronchoscopic brachytherapy was performed on 8 patients with roentgenographically occult lung cancer after biopsies proved malignant lesions of the trachea and bronchus in each case. These patients came to the National Cancer Center Hospital during the period from September 1992 to December 1992. Among these 8 cases of malignant lesions of the trachea and bronchus, 5 malignant lesions of the bronchus were diagnosed by bronchoscopic ultrasonography prior to the bronchoscopic brachytherapy, and these 5 patients have completed at least three courses of this therapy carried out by means of a videobronchoscope. Among the 8 cases of malignant lesions of the trachea and bronchus, complete remission was obtained in 7 cases. Of the 8 patients, the death of one patient was caused by amyotrophic lateral sclerosis, while the remaining 7 patients have survived for 13-15 months (14.1 months on average) to date, without showing recurrence or metastasis. As for the complications involved in this treatment, only a light degree of excessive secretions was observed, and there was no abscess formation in any of the cases. (author)

  7. Pediatric Sepsis Secondary to an Occult Dental Abscess: A Case Report.

    Science.gov (United States)

    Holmberg, Peter; Hellmich, Thomas; Homme, James

    2017-05-01

    In general, hematogenous spread of bacteria in children is uncommon. Bacteremia, however, is a known complication of dental procedures and severe caries, but is infrequently associated with primary, asymptomatic, non-procedural-related, dentoalveolar infection. The patient is a 7-year-old previously healthy boy who presented to the Emergency Department (ED) with "fever, mottling, and shaking chills." In the ED, he appeared systemically ill with fever, mottling, delayed capillary refill, and rigors. Physical examination by three different physicians failed to reveal any focus of infection. Laboratory evaluation, including blood cultures, was obtained. The patient later developed unilateral facial swelling and pain, and a dentoalveolar abscess was found. He was started on antibiotics, underwent pulpectomy and eventually, extraction, prior to improvement in symptoms. Blood cultures grew two separate anaerobic bacteria (Veillonella and Lactobacillus). This is, to our knowledge, one of the first reported cases of pediatric sepsis with two different anaerobic organisms secondary to occult dentoalveolar abscess in a pediatric patient. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: It is imperative for emergency physicians to recognize the possibility of pediatric sepsis in the setting of acute maxillary or mandibular pain, as well as in patients for whom no clear focus of infection can be found. This is particularly important for those who appear ill at presentation or meet systemic inflammatory response syndrome criteria and would benefit from further laboratory evaluation, including blood cultures, and possibly antibiotic therapy. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. Fundus autofluorescence and optical coherence tomographic findings in acute zonal occult outer retinopathy.

    Science.gov (United States)

    Fujiwara, Takamitsu; Imamura, Yutaka; Giovinazzo, Vincent J; Spaide, Richard F

    2010-09-01

    The purpose of this study was to investigate the fundus autofluorescence and optical coherence tomography findings in eyes with acute zonal occult outer retinopathy (AZOOR). A retrospective observational case series of the fundus autofluorescence and spectral domain optical coherence tomography in a series of patients with AZOOR. There were 19 eyes of 11 patients (10 women), who had a mean age of 49.1 +/- 13.9 years. Fundus autofluorescence abnormalities were seen in 17 of the 19 eyes, were more common in the peripapillary area, and were smaller in extent than the optical coherence tomography abnormalities. Nine eyes showed progression of hypoautofluorescence area during the mean follow-up of 69.7 months. The mean thickness of the photoreceptor layer at fovea was 177 microm in eyes with AZOOR, which was significantly thinner than controls (193 microm, P = 0.049). Abnormal retinal laminations were found in 12 eyes and were located over areas of loss of the photoreceptors. The subfoveal choroidal thickness was 243 microm, which is normal. Fundus autofluorescence abnormalities in AZOOR showed distinct patterns of retinal pigment epithelial involvement, which may be progressive. Thinning of photoreceptor cell layer with loss of the outer segments and abnormal inner retinal lamination in the context of a normal choroid are commonly found in AZOOR.

  9. Occult constrictive pericardial disease emerging 40 years after chest radiation therapy: a case report.

    Science.gov (United States)

    Goten, Chiaki; Murai, Hisayoshi; Takashima, Shin-Ichiro; Kato, Takeshi; Usui, Soichiro; Furusho, Hiroshi; Saeki, Takahiro; Sakagami, Satoru; Takemura, Hirofumi; Kaneko, Shuichi; Takamura, Masayuki

    2018-05-31

    The main etiology of constrictive pericarditis (CP) has changed from tuberculosis to therapeutic mediastinal radiation and cardiac surgery. Occult constrictive pericardial disease (OCPD) is a covert disease in which CP is manifested in a condition of volume overload. A 60-year-old patient with a history of thoracic radiation therapy for non-Hodgkin's lymphoma (40 years earlier) was transferred to our hospital for treatment of repeated congestive heart failure. For a preoperative hemodynamic study, pre-hydration with intravenous normal saline (50 mL/hour) was used to manifest the pericardial disease and prevent contrast-induced nephropathy. The hemodynamic study showed a right ventricular dip-plateau pattern and discordance of right and left ventricular systolic pressures during inspiration, which was not seen in the volume-controlled state. These responses were concordant with OCPD. A pericardiectomy, aortic valve replacement, and mitral and tricuspid valve repair were performed. Postoperatively, the heart failure was controlled with standard medication. This case revealed a volume-induced change in hemodynamics in OCPD with severe combined valvular heart disease, which suggests the importance of considering OCPD in patients who had undergone radiation therapy 40 years before.

  10. Occult CSF flow disturbance of patients with Alzheimer type dementia and vascular dementia

    International Nuclear Information System (INIS)

    Kono, Kazuhiko; Sugita, Yasuko; Funaki, Chiaki

    1994-01-01

    We report results of Iotrolan CT-cisternography on 41 demented patients (13 males and 28 females) to find 'occult normal pressure hydrocephalus'. These patients were suspected to have CSF flow disturbance from clinical symptoms and simple brain CT scan findings. Their average age, duration of dementia, and score of Hasegawa's dementia scale (HDS) were 76.2 years, 5.9 years, 9.5/32.5,respectively. Before performing CT-cisternography, clinical diagnosis for their dementia were vascular dementia in 18 patients. Alzheimer type dementia in 12, suspect of NPH in 5, and other diagnoses in 6. From the results of cisternography, we found 13 patients with CSF flow disturbance (contrast material remained in the ventricle more than 48 hours after injection), and 17 patients with normal CSF flow. The former showed lower scores of HDS, higher urinary incontinence scores and smaller areas of the interhemispheric fissure on CT scan than the latter. But the former showed no significant difference from the latter in the average age, duration of dementia and width of the ventricles. (author)

  11. First assimilations of COSMIC radio occultation data into the Electron Density Assimilative Model (EDAM

    Directory of Open Access Journals (Sweden)

    M. J. Angling

    2008-02-01

    Full Text Available Ground based measurements of slant total electron content (TEC can be assimilated into ionospheric models to produce 3-D representations of ionospheric electron density. The Electron Density Assimilative Model (EDAM has been developed for this purpose. Previous tests using EDAM and ground based data have demonstrated that the information on the vertical structure of the ionosphere is limited in this type of data. The launch of the COSMIC satellite constellation provides the opportunity to use radio occultation data which has more vertical information. EDAM assimilations have been run for three time periods representing quiet, moderate and disturbed geomagnetic conditions. For each run, three data sets have been ingested – only ground based data, only COSMIC data and both ground based and COSMIC data. The results from this preliminary study show that both ground and space based data are capable of improving the representation of the vertical structure of the ionosphere. However, the analysis is limited by the incomplete deployment of the COSMIC constellation and the use of auto-scaled ionosonde data. The first of these can be addressed by repeating this type of study once full deployment has been achieved. The latter requires the manual scaling of ionosonde data; ideally an agreed data set would be scaled and made available to the community to facilitate comparative testing of assimilative models.

  12. Gastric metastases originating from occult breast lobular carcinoma: diagnostic and therapeutic problems

    Directory of Open Access Journals (Sweden)

    Russo Leila

    2008-07-01

    Full Text Available Abstract Background Breast cancer is the most frequent malignant tumour to metastasize into the gastrointestinal tract in female and is second only to malignant melanoma. Nevertheless gastrointestinal metastases arising from breast cancer are quite rare. The upper gastrointestinal tract is more frequently involved and lobular infiltrating carcinoma has a greater predilection compared to the ductal type. Case presentation The authors describe the case of a 70 years old woman with a preoperative diagnosis of gastric undifferentiated medullary – type carcinoma, which was the first manifestation of an occult breast carcinoma. The primary site of carcinoma was identified with the use of a panel of selected immunohistochemical markers. Conclusion Our goal in this case report is to increase the awareness of surgeons and clinicians to rule out the possibility of mammary origin in circumstance of gastric cancer occurring in female, even in patients without a previous or concurrent history of breast carcinoma. Although not a particularly common event, it is, nevertheless, reported in the literature. The differentiation between primary gastric carcinoma and metastatic breast carcinoma is essential for planning the correct therapeutic approach, in order to avoid the patient unnecessary surgery.

  13. Angiographically occult vascular malformation of the brain: MR imaging at 1.5 T

    International Nuclear Information System (INIS)

    Patel, S.C.; Sanders, W.P.; Fuentes, J.; Haggar, A.M.; Mehta, B.A.; Boulos, R.S.; Froelich, J.W.

    1986-01-01

    MR imaging was performed in nine patients with 12 angiographically occult arteriovenous malformations using a 1.5-T superconducting magnet; four additional patients were imaged using a 0.3-T system. All images were reviewed in conjunction with CT scans. The following observations were made. (1) Eleven of 14 supratentorial lesions were located at the junction of gray and white matter. (2) Exclusing acute hemorrhage, only two lesions displayed mild mass effect. (3) All lesions displayed central foci of high signal intensity, probably representing subacute hemorrhage. (4) All lesions but one showed a peripheral rim of low signal intensity which progressively lost signal with increasing T2 weighting. This most likely represents iron-containing hemosiderin deposition. (5) Lesions were best demonstrated with long repetition times and moderate T2 weighting (TR = 2,500 msec, TE = 25-100 msec). (6) All lesions but one were hyperdense on non-contrast-enhanced CT, although only three had unequivocal calcification. The possibility of hyperdensity due to blood or iron deposition is discussed

  14. Clinical experience with 111In tropolonate leucocytes in the detection of occult infection

    International Nuclear Information System (INIS)

    Wraight, E.P.

    1988-01-01

    Over a period of 3 years, 275 scans were performed in 233 patients with suspected occult sepsis. A firm diagnosis was ultimately established in 160 cases. 81 sites of infection were correctly identified and there were 77 true negative studies. There were 4 false negative and 7 false positive studies, most of which were due to misinterpreting bowel activity as sepsis and vice versa. In 56 cases CT scans were performed within a few days of the leucocyte study. There was good agreement between the findings. Comparison was possible with ultrasound in 81 cases. In 15 of these ultrasound failed to detect infection in the abdomen which was demonstrated by 111 In leucocytes, suggesting that ultrasound is much less sensitive in this situation. The overall accuracy of 111 In leucocyte scanning in this series was 93,5%. The predictive value of a positive result was 92% and of a negative one 95%. The need for serial images to distinguish bowel activity (colitis or swallowed activity) from paracolic sepsis is emphasised. (orig.)

  15. Therapeutic Response for Functional Abdominal Pain in Children with Occult Constipation: Laxatives versus Prokinetic Drugs.

    Science.gov (United States)

    Ha, Eun Kyo; Jang, Homin; Jeong, Su Jin

    2017-01-01

    The relationship between functional abdominal pain (FAP) and occult constipation (OC) in children who did not meet the Rome III criteria for constipation has rarely been reported. This study aimed to estimate the prevalence of OC in patients with FAP and to compare the effectiveness of prokinetic drugs and laxatives for FAP and OC. Pediatric outpatients (n = 212; aged 4-15 years) who satisfied the Rome III criteria for childhood FAP were divided into 2 groups based on Leech scores: group 1 pain severity was assessed after 2 weeks, 1 month, and 3 months. A total 52.4% (111/212) of patients had OC in this study. More patients who received laxatives had reduced pain scores compared with those who received prokinetic drugs. Those treated with laxatives in group 2 had a better response than those treated with prokinetic drugs throughout the study period (P < 0.001, P < 0.001, and P = 0.002 after 2 weeks, 1 month, and 3 months, respectively). OC was frequently encountered in children with FAP. Laxatives can be more effective than prokinetic drugs for relieving symptoms of FAP in children with a Leech score ≥ 8 and suspected OC.

  16. Hand gesture recognition in confined spaces with partial observability and occultation constraints

    Science.gov (United States)

    Shirkhodaie, Amir; Chan, Alex; Hu, Shuowen

    2016-05-01

    Human activity detection and recognition capabilities have broad applications for military and homeland security. These tasks are very complicated, however, especially when multiple persons are performing concurrent activities in confined spaces that impose significant obstruction, occultation, and observability uncertainty. In this paper, our primary contribution is to present a dedicated taxonomy and kinematic ontology that are developed for in-vehicle group human activities (IVGA). Secondly, we describe a set of hand-observable patterns that represents certain IVGA examples. Thirdly, we propose two classifiers for hand gesture recognition and compare their performance individually and jointly. Finally, we present a variant of Hidden Markov Model for Bayesian tracking, recognition, and annotation of hand motions, which enables spatiotemporal inference to human group activity perception and understanding. To validate our approach, synthetic (graphical data from virtual environment) and real physical environment video imagery are employed to verify the performance of these hand gesture classifiers, while measuring their efficiency and effectiveness based on the proposed Hidden Markov Model for tracking and interpreting dynamic spatiotemporal IVGA scenarios.

  17. The Evolution and Application of Cardiac Monitoring for Occult Atrial Fibrillation in Cryptogenic Stroke and TIA.

    Science.gov (United States)

    Miller, Daniel J; Shah, Kavit; Modi, Sumul; Mahajan, Abhimanyu; Zahoor, Salman; Affan, Muhammad

    2016-04-01

    The evaluation of the stroke and transient ischemic attack (TIA) patient has been historically predominated by the initial evaluation in the hospital setting. As the etiology of stroke has eluded us in approximately one third of all acute events, the medical community has been eager to seek the answer to this mystery. In recent years, we have seen an explosion of innovations and trends allowing for a more detailed post stroke assessment strategy aimed at the identification of occult atrial fibrillation as the etiologic cause for the cryptogenic event. This has been achieved through the evolution and aggressive application and study of prolonged and advanced cardiac monitoring. This review is aimed to clarify and elucidate the standard and novel cardiac monitoring methods that have become available for use by the medical community and expected in the higher level care of cryptogenic stroke and TIA patients. These cardiac monitoring methods and devices are as heterogeneous as our patient population and have their own advantages and disadvantages. Many factors may be taken into consideration in choosing the appropriate cardiac monitoring method and are highlighted for consideration in this review. With a judicious approach to investigating the cryptogenic stroke population, and applying a wealth of novel treatment options, we may move forward into a new era of stroke prevention.

  18. Occult intraocular trauma: evaluation of the eye in an austere environment.

    Science.gov (United States)

    Sweet, Patrick H

    2013-03-01

    Physicians deployed to austere environments often encounter the challenge of needing to make clinical decisions based upon rudimentary history and physical examination. These skills, however, can be difficult for many to rely on, with the many subtleties of examining the eye, when they are normally accustomed to relying on sophisticated modalities to establish diagnosis. This case is a model for evaluating eye trauma in an austere or hostile environment. A 25-year-old male U.S. Marine was fired upon at a Mexican Army checkpoint where he sustained glass shrapnel injuries, the most serious being to his right eye. He was taken from a detention facility to a Mexican hospital, where he was evaluated and given the diagnosis of corneal laceration. Twelve hours later, a U.S. Navy physician arrived to evaluate the patient; he was allowed limited access to the patient. His ophthalmologic examination revealed a closed corneal laceration on the right eye, worse than 20/800 vision, absent red reflex, and obscured funduscopic examination. These findings made it impossible to rule out globe penetration. The patient was released 48 h later to a U.S. Naval Hospital, where intraocular foreign bodies were confirmed by imaging and he was taken to emergency surgery. This case illustrates that even under austere conditions, a focused history and evaluation can reveal the likelihood of occult intraocular foreign body, thereby triaging the patient for emergency surgery. Published by Elsevier Inc.

  19. AN OCCULTATION EVENT IN CENTAURUS A AND THE CLUMPY TORUS MODEL

    Energy Technology Data Exchange (ETDEWEB)

    Rivers, Elizabeth; Markowitz, Alex; Rothschild, Richard, E-mail: erivers@ucsd.edu [Center for Astrophysics and Space Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0424 (United States)

    2011-12-15

    We have analyzed 16 months of sustained monitoring observations of Centaurus A from the Rossi X-Ray Timing Explorer to search for changes in the absorbing column in the line of sight to the central nucleus. We present time-resolved spectroscopy which indicates that a discrete clump of material transited the line of sight to the central illuminating source over the course of {approx}170 days between 2010 August and 2011 February with a maximum increase in the column density of about 8.4 Multiplication-Sign 10{sup 22} cm{sup -2}. This is the best quality data of such an event that has ever been analyzed with the shape of the ingress and egress clearly seen. Modeling the clump of material as roughly spherical with a linearly decreasing density profile and assuming a distance from the central nucleus commensurate with the dusty torus, we found that the clump would have a diameter of (1.4-2.4) Multiplication-Sign 10{sup 15} cm with a central number density of n{sub H} = (1.8-3.0) Multiplication-Sign 10{sup 7} cm{sup -3}. This is consistent with previous results for a similar (though possibly much longer) occultation event inferred in this source in 2003-2004 and supports models of the molecular torus as a clumpy medium.

  20. AN OCCULTATION EVENT IN CENTAURUS A AND THE CLUMPY TORUS MODEL

    International Nuclear Information System (INIS)

    Rivers, Elizabeth; Markowitz, Alex; Rothschild, Richard

    2011-01-01

    We have analyzed 16 months of sustained monitoring observations of Centaurus A from the Rossi X-Ray Timing Explorer to search for changes in the absorbing column in the line of sight to the central nucleus. We present time-resolved spectroscopy which indicates that a discrete clump of material transited the line of sight to the central illuminating source over the course of ∼170 days between 2010 August and 2011 February with a maximum increase in the column density of about 8.4 × 10 22 cm –2 . This is the best quality data of such an event that has ever been analyzed with the shape of the ingress and egress clearly seen. Modeling the clump of material as roughly spherical with a linearly decreasing density profile and assuming a distance from the central nucleus commensurate with the dusty torus, we found that the clump would have a diameter of (1.4-2.4) × 10 15 cm with a central number density of n H = (1.8-3.0) × 10 7 cm –3 . This is consistent with previous results for a similar (though possibly much longer) occultation event inferred in this source in 2003-2004 and supports models of the molecular torus as a clumpy medium.

  1. [Faecal occult blood test for colorectal cancer screening: high quality for a good price].

    Science.gov (United States)

    van Veldhuizen, Harriët; Bonfrer, J M G Hans; Kuipers, Ernst J

    2013-01-01

    The Dutch National Institute for Public Health and the Environment (RIVM) awarded the immunochemical faecal occult blood test (IFOBT) to FOB Gold of Sentinel following a European call for tenders. The contract-awarding procedure included the application of quality knock-out criteria, which were met by two suppliers. The decisive factor was the best price/quality ratio. A recent review indicated that, at present, no single IFOBT is better than any other. The decision to opt for a test manufactured by a different supplier than was used in the previous screening pilots made it necessary to re-determine the cut-off value. This value has now been set (88 ng/ml) and is confirmed by a laboratory test. Colonoscopy-related capacity planning, as well as its diagnostic yield, depends on numerous factors; therefore, the RIVM is currently monitoring the referral percentage and number of adenomas detected and is collaborating on quality terms. Any necessary adjustments are to be made during the introduction of the screening test.

  2. Spatial irregularities in Jupiter's upper ionosphere observed by voyager radio occultations

    Energy Technology Data Exchange (ETDEWEB)

    Hinson, D.P.; Tyler, G.L.

    1982-07-01

    Dual frequency radio occultation experiments carried out with Voyagers 1 and 2 provided data on the spatial irregularities in Jupiter's ionosphere at four different locations. Sample spectra of weak fluctuations in amplitude and phase of the 3.6-cm and 13-cm wavelength radio signals can be interpreted by using the theory for scattering from an anisotropic power law phase screen. Least squares solutions for ionospheric parameters derived from the observed fluctuation spectra yielded estimates of (1) the axial ratio, (2) angular orientation of the anisotropic irregularities, (3) the power law exponent of the spatial spectrum of irregularities, and (4) the magnitude of the spatial variations in electron density. Equipment limitations and the method of analysis constrain the observations to irregularities of approximate size 1--200 km. No evidence of the inner or outer scale of the irregularities was found. For length scales in the range given, the three-dimensional spatial spectrum obeys a power law with exponent varying from -3.0 to -3.7, and the root mean square fractional variations in electron density are 1--15%. All observed irregularities appear to be anisotropic with axial ratios between 2:1 and 10:1. Ionospheric parameters vary with altitude and latitude. We conclude that the measured angular orientation of the anisotropic irregularities indicates magnetic field direction and may provide a basis for refining Jovian magnetic field models.

  3. Polydimethylsiloxane: a new contrast material for localization of occult breast lesions

    International Nuclear Information System (INIS)

    Vitral, Geraldo Sérgio Farinazzo; Raposo, Nádia Rezende Barbosa

    2011-01-01

    The radioguided localization of occult breast lesions (ROLL) technique often utilizes iodinated radiographic contrast to assure that the local injection of 99m Tc-MAA corresponds to the location of the lesion under investigation. However, for this application, this contrast has several shortcomings. The objective of this study was to evaluate the safety, effectiveness and technical feasibility of the use of polydimethylsiloxane (PDMS) as radiological contrast and tissue marker in ROLL. The safety assessment was performed by the acute toxicity study in Wistar rats (n = 50). The radiological analysis of breast tissue (n = 32) from patients undergoing reductive mammoplasty was used to verify the effectiveness of PDMS as contrast media. The technical feasibility was evaluated through the scintigraphic and histologic analysis. We found no toxic effects of PDMS for this use during the observational period. It has been demonstrated in human breast tissue that the average diameter of the tissue marked by PDMS was lower than when marked by the contrast medium (p <0.001). PDMS did not interfere with the scintigraphic uptake (p = 0.528) and there was no injury in histological processing of samples. This study demonstrated not only the superiority of PDMS as radiological contrast in relation to the iodinated contrast, but also the technical feasibility for the same applicability in the ROLL

  4. Acute paraparesis as presentation of an occult follicular thyroid carcinoma: A case report

    Directory of Open Access Journals (Sweden)

    José Miguel Baião

    Full Text Available Introduction: Follicular thyroid carcinoma is the second most frequent type of well differentiated thyroid tumours. It is usually confined to the thyroid gland, however it can metastasize in a later stage of the disease. Signs and symptoms associated with bone metastasis are rare as first clinical manifestations. Case report: An 84-year-old female complained with acute paraparesis. Magnetic resonance imaging revealed an extensive intraosseous infiltrating lesion compatible with a bone metastasis from an occult tumour. Biopsy samples were compatible with bone metastasis from a follicular thyroid carcinoma. The patient was submitted to total thyroidectomy followed by iodine ablative therapy. Discussion: Follicular thyroid carcinoma presentation with symptoms related to bone metastasis is rare. Patients with bone lesions, such as pathological fractures or compressive symptoms should be studied since they may have clinically unapparent lesions from an unknown tumour. Patients with FTC should be submitted to total thyroidectomy. Bone lesions may be addressed to improve quality of life however this decision depends on disease extent. Conclusion: Acute paraparesis is a rare form of presentation of thyroid carcinoma. These neoplasms must be taken into account when investigating metastasis to the bone from unknown neoplasms. Keywords: Acute paraparesis, Follicular thyroid carcinoma, Bone metastasis, Case report

  5. Prevalence, risk factors, and impact of isolated antibody to hepatitis B core antigen and occult hepatitis B virus infection in HIV-1-infected pregnant women.

    Science.gov (United States)

    Khamduang, Woottichai; Ngo-Giang-Huong, Nicole; Gaudy-Graffin, Catherine; Jourdain, Gonzague; Suwankornsakul, Weerapong; Jarupanich, Tapnarong; Chalermpolprapa, Veeradate; Nanta, Sirisak; Puarattana-Aroonkorn, Noossara; Tonmat, Sakchai; Lallemant, Marc; Goudeau, Alain; Sirirungsi, Wasna

    2013-06-01

    Prevalence and risk factors for isolated antibody to hepatitis B core antigen (anti-HBc) and occult hepatitis B virus (HBV) infection are not well known in human immunodeficiency virus type 1 (HIV-1)-infected pregnant women. It is unclear if women with occult infections are at risk of transmitting HBV to their infants. HIV-1-infected and HBV surface antigen (HBsAg)-negative pregnant women were tested for antibody to HBsAg (anti-HBs) and anti-HBc using enzyme immunoassay. Women with isolated anti-HBc were assessed for occult HBV infection, defined as HBV DNA levels >15 IU/mL, using the Abbott RealTime HBV DNA assay. Infants born to women with isolated anti-HBc and detectable HBV DNA were tested at 4 months of age for HBV DNA. Logistic regression analysis was used to identify factors associated with isolated anti-HBc and occult HBV infection. Among 1812 HIV-infected pregnant women, 1682 were HBsAg negative. Fourteen percent (95% confidence interval [CI], 12%-15%) of HBsAg-negative women had an isolated anti-HBc that was independently associated with low CD4 count, age >35 years, birth in northern Thailand, and positive anti-hepatitis C virus serology. Occult HBV infection was identified in 24% (95% CI, 18%-30%) of women with isolated anti-HBc, representing 2.6% (95% CI, 1.9%-3.5%) of HIV-1-infected pregnant women, and was inversely associated with HIV RNA levels. None of the women with isolated anti-HBc and occult HBV infection transmitted HBV to their infants. HIV-1-infected pregnant women with isolated anti-HBc and occult HBV infection have very low HBV DNA levels and are thus at very low risk to transmit HBV to their infants.

  6. Stress Management

    Science.gov (United States)

    Healthy Lifestyle Stress management By Mayo Clinic Staff Stress basics Stress is a normal psychological and physical reaction to the demands of life. ... some people's alarm systems rarely shut off. Stress management gives you a range of tools to reset ...

  7. Manage Stress

    Science.gov (United States)

    ... Manage Stress Print This Topic En español Manage Stress Browse Sections The Basics Overview Signs and Health ... and Health Effects What are the signs of stress? When people are under stress, they may feel: ...

  8. Stress Incontinence

    Science.gov (United States)

    Stress incontinence Overview Urinary incontinence is the unintentional loss of urine. Stress incontinence happens when physical movement or activity — such ... coughing, sneezing, running or heavy lifting — puts pressure (stress) on your bladder. Stress incontinence is not related ...

  9. Nuclear energy. Unmasking the mystery

    International Nuclear Information System (INIS)

    1988-08-01

    The Standing Committee on Energy, Mines and Resources of the House of Commons of Canada undertook a study of the economics of nuclear power in Canada. This is its report on the evidence it heard. It found that maintaining the nuclear power option is vital to Canada's interests. The Committee recommended that: the schedule for establishing a commercial high-level radioactive waste repository be advanced; the basic insurance coverage on nuclear facilities be raised; the federal government increase its financial support of Atomic Energy of Canada Ltd. (AECL); AECL expand its research and development activities, including non-nuclear R and D; AECL be allowed to hold a minority interest in any component of AECL that is privatized; any new entity created by privatization from AECL be required to remain under Canadian control; the Atomic Energy Control Act be altered to allow the Atomic Energy Control Board (AECB) to recover costs through licensing fees and user charges, while the AECB's parliamentary appropriation is increased to offset remaining costs of operations; membership on the AECB be increased from one to five full-time members, retaining the present four part-time members; the AECB hold its hearings in public; the name of the AECB be changed so it is more readily distinguishable from AECL; the AECB establish an office of public information; and that federal and provincial governments cooperate more closely to identify opportunities where more efficient use of electricity could be achieved and to promote those measures that can attain the greatest economic efficiency

  10. A Scaphoid Stress Fracture in a Female Collegiate-Level Shot-Putter and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Jessica M. Kohring

    2016-01-01

    Full Text Available Scaphoid stress fractures are rare injuries that have been described in young, high-level athletes who exhibit repetitive loading with the wrist in extension. We present a case of an occult scaphoid stress fracture in a 22-year-old female Division I collegiate shot-putter. She was successfully treated with immobilization in a thumb spica splint for 6 weeks. Loaded wrist extension activities can predispose certain high-level athletes to sustain scaphoid stress fractures, and a high index of suspicion in this patient population may aid prompt diagnosis and management of this rare injury.

  11. Water vapour and methane coupling in the stratosphere observed using SCIAMACHY solar occultation measurements

    Directory of Open Access Journals (Sweden)

    S. Noël

    2018-04-01

    Full Text Available An improved stratospheric water vapour data set has been retrieved from SCIAMACHY/ENVISAT solar occultation measurements. It is similar to that successfully applied to methane and carbon dioxide. There is now a consistent set of data products for the three constituents covering the altitudes 17–45 km, the latitude range between about 50 and 70° N, and the period August 2002 to April 2012. The new water vapour concentration profiles agree with collocated results from ACE-FTS and MLS/Aura to within  ∼  5 %. A significant positive linear change in water vapour for the time 2003–2011 is observed at lower stratospheric altitudes with a value of about 0.015 ± 0.008 ppmv year−1 around 17 km. Between 30 and 37 km the changes become significantly negative (about −0.01 ± 0.008 ppmv year−1; all errors are 2σ values. The combined analysis of the SCIAMACHY methane and water vapour time series shows the expected anti-correlation between stratospheric methane and water vapour and a clear temporal variation related to the Quasi-Biennial Oscillation (QBO. Above about 20 km most of the additional water vapour is attributed to the oxidation of methane. In addition short-term fluctuations and longer-term variations on a timescale of 5–6 years are observed. The SCIAMACHY data confirm that at lower altitudes the amount of water vapour and methane are transported from the tropics to higher latitudes via the shallow branch of the Brewer–Dobson circulation.

  12. Occult inflammatory breast cancer: review of clinical, mammographic, US and pathologic signs

    International Nuclear Information System (INIS)

    Cumo, Francesca; Gaioni, Maria Berenice; Bonetti, Franco; Manfrin, Erminia; Remo, Andrea; Pattaro, Christian; Policlinico G.B. Rossi, Verona

    2005-01-01

    Purpose: To examine the clinical, radiologic and pathologic findings of occult inflammatory breast cancer (OIBC) in order to identify features useful for diagnosis. Materials and methods: We retrospectively reviewed the records of 19 women with OIBC observed at our Department between 1992 and 2001. We analysed the clinical history, mammographic, ultrasonographic, and pathologic findings and investigated overall survival (OS), prognostic variables and radio-pathologic correlations. Results: The most common mammographic findings were: diffusely density (52.63%), trabecular thickening (42.1%), mass (36.84%). The most common US findings were axillary lymphadenopathy (68,75%), skin thickening (43.75%) and mass (56.25%). At least one inflammatory sign was found in 14 women (74%) at mammography (subcutaneous thickening, trabecular thickening, diffuse increase of density) or at US (subcutaneous thickening, diffuse increase in echogenicity due to oedema, lymph vessel dilatation). Estrogen receptors (ER) were present in 63.2% and Progesterone receptors (PgR) in 36.8%. Significant prognostic variables were ER and Ki 67. Conclusions: The typical radiological pattern of clinical inflammatory breast carcinoma is less frequently present in OIBC; nevertheless the radiologist must pay attention because frequently OIBC presents just one radiological sign and this should be enough for a diagnostic suspicion. Moreover, the absence of clinical and radiological inflammatory signs does not exclude inflammatory breasts cancer because OIBC can manifest at imaging as a mass or isolated calcification. ER and PgR are positive in a high percentage of patients and confirm that OIBC has a better prognosis that clinical inflammatory breast cancer [it

  13. A Comprehensive Assessment of Radio Occultation Ionospheric Measurements at Mid-Latitudes

    Science.gov (United States)

    Keele, C.; Brum, C. G. M.; Rodrigues, F. S.; Aponte, N.; Sulzer, M. P.

    2015-12-01

    The GPS radio occultation (RO) has become a widely used technique for global measurements of the ionospheric electron density (Ne). To advance our understanding of the accuracy of the RO profiles at mid latitudes, we performed a comprehensive comparison of RO measurements made by the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) satellites and observations of Ne profiles made by the Arecibo Observatory incoherent scatter radar (ISR). COSMIC is formed by six satellites in circular, 800 km altitude low-Earth orbit (LEO) at 72° inclination. The satellites orbit in their own plane, approximately 24° apart in ascending node. The satellites are equipped with dual-frequency GPS receivers capable of making measurements of the total electron content (TEC) along the signal path and, therefore, RO observations. The Arecibo ISR, located at(18.35°N, 66.75°W; ˜28.25°N dip latitude), operates at a frequency of 430 MHz with a maximum bandwidth of about 1 MHz. The large collecting area provided by the 300 m dish antenna combined with high peak power transmitters (2.0-2.5 MW) allows the radar to make accurate Ne measurements throughout the entire ionospheric F-region and topside heights. We analyzed 74 and 89 days of line feed and Gregorian data, respectively, collected between 2006 and 2014. There were 638 RO profiles measured within 10° of latitude and 20° of longitude from Arecibo Observatory and within ±10 minutes of the radar measurements. Preliminary analyses of the observations show patterns in the relationship between densities measured by the Arecibo ISR and densities estimated from the COSMIC ROs. We will present and discuss the behavior of the patterns. We will also present results of a numerical model representing the patterns and discuss the possibility of using this model to improve RO estimates of density profiles.

  14. Occult Amebic Liver Abscess as Cause of Extensive Inferior Vena Cava and Hepatic Vein Thrombosis.

    Science.gov (United States)

    Martin, Leslie; Burute, Nishigandha; Haider, Ehsan; Serrano, Pablo E; O'Shea, Timothy; Siegal, Deborah

    2017-10-01

    The most common extraintestinal complication of Entamoeba histolytica is amebic liver abscess (ALA). Hepatic vein and inferior vena cava (IVC) thrombosis are rare but well-documented complications of ALA, typically attributed to mechanical compression and inflammation associated with a large abscess. We present a case of a previously healthy 43-year-old Canadian man presenting with constitutional symptoms and right upper quadrant abdominal pain. He was found to have thrombophlebitis of the IVC, accessory right hepatic vein, and bilateral iliac veins. Extensive investigations for thrombophilia were negative. Magnetic resonance imaging of the liver demonstrated a 3.2-cm focal area of parenchymal abnormality that was reported as presumptive hepatocellular carcinoma, and a 1.9-cm lesion in the caudate lobe with diffusion restriction and peripheral rim enhancement. Despite multiple biopsy attempts, a histopathological diagnosis was not achieved. Abdominal pain and fever 4 months later prompted repeat ultrasound demonstrating a 10.4- × 12.0-cm rim-enhancing fluid attenuation lesion felt to represent a liver abscess. Thick dark "chocolate brown" drainage from the lesion and positive serology for E. histolytica confirmed the diagnosis of ALA acquired from a previous trip to Cuba. The patient was started on treatment with metronidazole and paromomycin and repeat abdominal ultrasound demonstrated resolution of the abscess. This case is the first to demonstrate extensive IVC thrombosis secondary to a relatively small occult ALA and emphasizes the thrombogenic potential of ALA. Amebic infection should be considered as a rare cause of IVC thrombosis in the correct clinical context.

  15. Harmonic analysis of the ionospheric electron densities retrieved from FORMOSAT-3/COSMIC radio occultation measurements

    Science.gov (United States)

    Masoumi, S.; Safari, A.; Sharifi, M.; Sam Khaniani, A.

    2011-12-01

    In order to investigate regular variations of the ionosphere, the least-squares harmonic estimation is applied to the time series of ionospheric electron densities in the region of Iran derived from about five years of Global Positioning System Radio Occultation (GPS RO) observations by FORMOSAT-3/COSMIC satellites. Although the obtained results are slightly different from the expected ones due to the low horizontal resolution of RO measurements, high vertical resolution of the observations enables us to detect not only the Total Electron Content (TEC) variations, but also periodic patterns of electron densities in different altitudes of the ionosphere. Dominant diurnal and annual signals, together with their Fourier series decompositions, and also periods close to 27 days are obtained, which is consistent with the previous analyses on TEC. In the equatorial anomaly band, the annual component is weaker than its Fourier decomposition periods. In particular, the semiannual period dominates the annual component, which is probably due to the effect of geomagnetic field. By the investigation of the frequencies at different local times, the semiannual signal is more significant than the annual one in the daytime, while the annual frequency is dominant at night. By the detection of the phases of the components, it is revealed that the annual signal has its maximum in summer at high altitudes, and in winter at lower altitudes. This suggests the effect of neutral compositions in the lower atmosphere. Further, the semiannual component peaks around equinox during the day, while its maximum mostly occurs in solstice at night. Since RO measurements can be used to derive TEC along the signal path between a GPS satellite and a receiver, study on the potentiality of using these observations for the prediction of electron densities and its application to the ionospheric correction of the single frequency receivers is suggested.

  16. Evaluating the lower-tropospheric COSMIC GPS radio occultation sounding quality over the Arctic

    Science.gov (United States)

    Yu, Xiao; Xie, Feiqin; Ao, Chi O.

    2018-04-01

    Lower-tropospheric moisture and temperature measurements are crucial for understanding weather prediction and climate change. Global Positioning System radio occultation (GPS RO) has been demonstrated as a high-quality observation technique with high vertical resolution and sub-kelvin temperature precision from the upper troposphere to the stratosphere. In the tropical lower troposphere, particularly the lowest 2 km, the quality of RO retrievals is known to be degraded and is a topic of active research. However, it is not clear whether similar problems exist at high latitudes, particularly over the Arctic, which is characterized by smooth ocean surface and often negligible moisture in the atmosphere. In this study, 3-year (2008-2010) GPS RO soundings from COSMIC (Constellation Observing System for Meteorology, Ionosphere, and Climate) over the Arctic (65-90° N) show uniform spatial sampling with average penetration depth within 300 m above the ocean surface. Over 70 % of RO soundings penetrate deep into the lowest 300 m of the troposphere in all non-summer seasons. However, the fraction of such deeply penetrating profiles reduces to only about 50-60 % in summer, when near-surface moisture and its variation increase. Both structural and parametric uncertainties of GPS RO soundings were also analyzed. The structural uncertainty (due to different data processing approaches) is estimated to be within ˜ 0.07 % in refractivity, ˜ 0.72 K in temperature, and ˜ 0.05 g kg-1 in specific humidity below 10 km, which is derived by comparing RO retrievals from two independent data processing centers. The parametric uncertainty (internal uncertainty of RO sounding) is quantified by comparing GPS RO with near-coincident radiosonde and European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-Interim profiles. A systematic negative bias up to ˜ 1 % in refractivity below 2 km is only seen in the summer, which confirms the moisture impact on GPS RO quality.

  17. Early detection of Haemonchus contortus infection in sheep using three different faecal occult blood tests

    Directory of Open Access Journals (Sweden)

    A.V. Rodríguez

    2015-07-01

    Full Text Available Haemonchus contortus is a blood-sucking parasite causing the presence of faecal occult blood (FOB. The objective was to study three different FOB tests in order to have a new indicator of H. contortus infection in sheep that could be included in the genetic evaluation system as an alternative selection criterion to faecal worm egg count (FEC. A total of 29 Corriedale lambs were experimentally infected with 10.000 larvae of H. contortus. Stool samples were recorded for FEC and FOB tests (Hexagon, Hematest® and Multistix®, blood for packed cell volume (PCV, haemoglobin, white and red blood cell count (RBC, and FAMACHA© for scoring anaemia. At the end of the experiment lambs were slaughtered to worm burden count. Field infection was achieved in 309 Merino lambs under natural parasite challenge. FEC data were normalized through logarithmic transformation (LnFEC. Pearson correlation was estimated to examine the relationship between all traits. The three tests were able to detect the presence of FOB at day 11. FEC, PCV and RBC decreased to sub-normal values from day 18. FAMACHA© score 3 was considered to be indicative of anaemia. Most of the correlations were of high magnitude, with the exception of Multistix® test that was moderately correlated with haematological parameters, LnFEC and FEC. In field infection, most samples were negative to FOB tests and the correlations were lower than those calculated under experimental infection. In conclusion, FOB tests were able to detect haemonchosis earlier than FEC under high experimental parasite challenge. However, they were not able to detect FOB under natural mixed parasite challenge. FAMACHA© and PCV demonstrated to be good indicators of Haemonchosis, having moderate to high correlations with FEC.

  18. POPULATION BASED COLORECTAL CANCER SCREENING: COMPARISON OF TWO FAECAL OCCULT BLOOD TESTS

    Directory of Open Access Journals (Sweden)

    Miren Begoña eZubero

    2014-01-01

    Full Text Available Background: The aim of screening for colorectal cancer is to improve prognosis by the detection of cancer at its early stages. In order to inform the decision on the specific test to be used in the population-based programme in the Basque Autonomous Region (Spain, we compared two immunochemical faecal occult blood quantitative tests (I-FOBT. Methods: Residents of selected study areas, aged 50-69 years, were invited to participate in the screening. Two tests based on latex agglutination (OC-Sensor and FOB Gold were randomly assigned to different study areas. A colonoscopy was offered to patients with a positive test result. The cut-off point used to classify a result as positive, according to manufacturer’s recommendations, was 100 ng/ml for both tests. Results: The invited population included 37,999 individuals. Participation rates were 61.8% (n=11,162 for OC-Sensor and 59.1% (n=11,786 for FOB Gold, (p=0.008. Positive rate for OC-Sensor was 6.6% (n=737 and 8.5% (n=1,002 for FOB Gold, (pConclusions: OC-Sensor test appears to be superior for I-FOBT based CRC screening, given its acceptance, ease of use, associated small number of errors and its screening accuracy. FOB-Gold on the other hand, has higher rate of positive values, with more colonoscopies performed, it shows higher detection incidence rates, but involves more false positives.

  19. Cassini Radio Occultations of Saturn's Ionosphere: Modeling a Variable Influx of Water into Saturn's Atmosphere

    Science.gov (United States)

    Moore, L.; Mendillo, M.

    2006-12-01

    The Saturn-Thermosphere-Ionosphere-Model (STIM), a global circulation model (GCM) of Saturn's upper atmosphere, is used to investigate a range of possible parameters that could lead to the profiles measured recently by the Radio Science Subsystem (RSS) aboard Cassini. Specifically, electron density observations of Saturn's equatorial ionosphere demonstrate a dawn/dusk asymmetry, a possible double peak, and a high degree of vertical structure and variability. On average, peak electron densities are larger at dusk than dawn (5400 cm-3 vs. 1700 cm-3) and the peak altitudes are lower at dusk than dawn (1880 km vs. 2360 km). Self-consistent, time-dependent 1D water diffusion calculations have been combined with the GCM in order to examine the possibility that a topside flux of neutral water into Saturn's atmosphere may provide a loss mechanism -- via charge exchange with protons -- that is sufficient to reproduce the observed ionosphere. Our previous modeling results indicated that a constant background influx of (0.5 -- 1.0) x 107 H2O cm-2 sec-1 was adequate in reproducing Cassini measurements on average [Moore et al., 2006], however the large observed variations in the vertical electron density profiles require additional complexities in the modeling. In this study we show that one possible source of the structuring observed in the electron density profiles could be from brief surges and/or reductions in the background water flux, which ultimately may be linked to geysers near Enceladus' southern pole. Moore, L., A.F. Nagy, A.J. Kliore, I. Mueller-Wodarg, J.D. Richardson, M. Mendillo (2006), Cassini radio occultations of Saturn's ionopshere: I. model comparisons using a constant water flux, submitted to GRL.

  20. A global perspective on atmospheric blocking using GPS radio occultation – one decade of observations

    Directory of Open Access Journals (Sweden)

    L. Brunner

    2017-12-01

    Full Text Available Atmospheric blocking represents a weather pattern where a stationary high-pressure system weakens or reverses the climatological westerly flow at mid-latitudes for up to several weeks. It is closely connected to strong anomalies in key atmospheric variables such as geopotential height, temperature, and humidity. Here we provide, for the first time, a comprehensive, global perspective on atmospheric blocking and related impacts by using an observation-based data set from Global Positioning System (GPS radio occultation (RO from 2006 to 2016. The main blocking regions in both hemispheres and seasonal variations are found to be represented well in RO data. The effect of blocking on vertically resolved temperature and humidity anomalies in the troposphere and lower stratosphere is investigated for blocking regions in the Northern and Southern hemispheres, respectively. We find a statistically significant correlation of blocking with positive temperature anomalies, exceeding 3 K in the troposphere, and a reversal above the tropopause with negative temperature anomalies below −3 K in the lower stratosphere. Specific humidity is positively correlated with temperature throughout the troposphere with larger anomalies revealed in the Southern Hemisphere. At the eastern and equatorward side of the investigated blocking regions, a band of tropospheric cold anomalies reveals advection of cold air by anticyclonic motion around blocking highs, which is less distinct in the Southern Hemisphere due to stronger zonal flow. We find GPS RO to be a promising new data set for blocking research that gives insight into the vertical atmospheric structure, especially in light of the expected increase in data coverage that future missions will provide.

  1. Role of ultrasonography in detecting mammographically occult breast carcinoma in women with dense breasts.

    Science.gov (United States)

    Corsetti, V; Ferrari, A; Ghirardi, M; Bergonzini, R; Bellarosa, S; Angelini, O; Bani, C; Ciatto, S

    2006-04-01

    The purpose of this study was to assess the usefulness of routine ultrasonography in women with negative mammography and dense breasts [Breast Imaging Reporting and Data System (BIRADS D3-4)]. We applied a protocol involving routine ultrasonography in a consecutive series of subjects with negative mammography and dense breasts. After evaluation by internal and external reviewers of cancers detected by ultrasonography performed to confirm negative mammography, we determined the additional cancer detection rate of ultrasonography and the cost of the protocol. Out of 17,883 total mammographies, 167 cancers were diagnosed (detection rate: 0.93%). Out of 257 suspicious mammographies, 138 cancers were detected. Out of 17,626 negative mammographies, 6,449 (36.5%) were classified as "dense breast" and underwent ultrasonography: 29 cancers were detected (detection rate: 0.44%, or 17.3% of total cancers). Out of 25 cancer cases reviewed, negative mammography and asymptomatic status was confirmed in 15 (detection rate 0.23%, or 8.9% of total cancers). The cancer detection rate was 0.11%, 0.22%, 0.32% and 0.14% for age groups 59, respectively. The cost per additional carcinoma detected by ultrasonography alone was euro 25,847.85 whereas that per examined woman was euro 21.68. The study confirms the possibility that ultrasonography can detect mammographically occult breast carcinoma in dense breasts. The evidence is insufficient to recommend this policy in routine screening practice but suggests that, at least in current clinical practice, adding ultrasonography in dense breasts may be useful despite the substantial costs.

  2. The impact of large scale ionospheric structure on radio occultation retrievals

    Directory of Open Access Journals (Sweden)

    A. J. Mannucci

    2011-12-01

    Full Text Available We study the impact of large-scale ionospheric structure on the accuracy of radio occultation (RO retrievals. We use a climatological model of the ionosphere as well as an ionospheric data assimilation model to compare quiet and geomagnetically disturbed conditions. The presence of ionospheric electron density gradients during disturbed conditions increases the physical separation of the two GPS frequencies as the GPS signal traverses the ionosphere and atmosphere. We analyze this effect in detail using ray-tracing and a full geophysical retrieval system. During quiet conditions, our results are similar to previously published studies. The impact of a major ionospheric storm is analyzed using data from the 30 October 2003 "Halloween" superstorm period. At 40 km altitude, the refractivity bias under disturbed conditions is approximately three times larger than quiet time. These results suggest the need for ionospheric monitoring as part of an RO-based climate observation strategy. We find that even during quiet conditions, the magnitude of retrieval bias depends critically on assumed ionospheric electron density structure, which may explain variations in previously published bias estimates that use a variety of assumptions regarding large scale ionospheric structure. We quantify the impact of spacecraft orbit altitude on the magnitude of bending angle and retrieval error. Satellites in higher altitude orbits (700+ km tend to have lower residual biases due to the tendency of the residual bending to cancel between the top and bottomside ionosphere. Another factor affecting accuracy is the commonly-used assumption that refractive index is unity at the receiver. We conclude with remarks on the implications of this study for long-term climate monitoring using RO.

  3. Occult pneumothorax in Chinese patients with significant blunt chest trauma: incidence and management.

    Science.gov (United States)

    Lee, Ka L; Graham, Colin A; Yeung, Janice H H; Ahuja, Anil T; Rainer, Timothy H

    2010-05-01

    Occult pneumothorax (OP) is a pneumothorax not visualised on a supine chest X-ray (CXR) but detected on computed tomography (CT) scanning. With increasing CT use for trauma, more OP may be detected. Management of OP remains controversial, especially for patients undergoing mechanical ventilation. This study aimed to identify the incidence of OP using thoracic CT as the gold standard and describe its management amongst Hong Kong Chinese trauma patients. Analysis of prospectively collected trauma registry data. Consecutive significantly injured trauma patients admitted through the emergency department (ED) suffering from blunt chest trauma who underwent thoracic computed tomography (TCT) between in calendar years 2007 and 2008 were included. An OP was defined as the identification (by a specialist radiologist) of a pneumothorax on TCT that had not been previously detected on supine CXR. 119 significantly injured patients were included. 56 patients had a pneumothorax on CXR and a further 36 patients had at least one OP [OP incidence 30% (36/119)]. Bilateral OP was present in 8/36 patients, so total OP numbers were 44. Tube thoracostomy was performed for 8/44 OP, all were mechanically ventilated in the ED. The remaining 36 OP were managed expectantly. No patients in the expectant group had pneumothorax progression, even though 8 patients required subsequent ventilation in the operating room for extrathoracic surgery. The incidence of OP (seen on TCT) in Chinese patients in Hong Kong after blunt chest trauma is higher than that typically reported in Caucasians. Most OP were managed expectantly without significant complications; no pneumothorax progressed even though some patients were mechanically ventilated. (c) 2010 Elsevier Ltd. All rights reserved.

  4. Atmospheric QBO and ENSO indices with high vertical resolution from GNSS radio occultation temperature measurements

    Science.gov (United States)

    Wilhelmsen, Hallgeir; Ladstädter, Florian; Scherllin-Pirscher, Barbara; Steiner, Andrea K.

    2018-03-01

    We provide atmospheric temperature variability indices for the tropical troposphere and stratosphere based on global navigation satellite system (GNSS) radio occultation (RO) temperature measurements. By exploiting the high vertical resolution and the uniform distribution of the GNSS RO temperature soundings we introduce two approaches, both based on an empirical orthogonal function (EOF) analysis. The first method utilizes the whole vertical and horizontal RO temperature field from 30° S to 30° N and from 2 to 35 km altitude. The resulting indices, the leading principal components, resemble the well-known patterns of the Quasi-Biennial Oscillation (QBO) and the El Niño-Southern Oscillation (ENSO) in the tropics. They provide some information on the vertical structure; however, they are not vertically resolved. The second method applies the EOF analysis on each altitude level separately and the resulting indices contain information on the horizontal variability at each densely available altitude level. They capture more variability than the indices from the first method and present a mixture of all variability modes contributing at the respective altitude level, including the QBO and ENSO. Compared to commonly used variability indices from QBO winds or ENSO sea surface temperature, these new indices cover the vertical details of the atmospheric variability. Using them as proxies for temperature variability is also of advantage because there is no further need to account for response time lags. Atmospheric variability indices as novel products from RO are expected to be of great benefit for studies on atmospheric dynamics and variability, for climate trend analysis, as well as for climate model evaluation.

  5. Assessment of NOAA NUCAPS upper air temperature profiles using COSMIC GPS radio occultation and ARM radiosondes

    Science.gov (United States)

    Feltz, M. L.; Borg, L.; Knuteson, R. O.; Tobin, D.; Revercomb, H.; Gambacorta, A.

    2017-09-01

    The U.S. National Oceanic and Atmospheric Administration (NOAA) recently began operational processing to derive vertical temperature profiles from two new sensors, Cross-Track Infrared Sounder and Advanced Technology Microwave Sounder, which were developed for the next generation of U.S. weather satellites. The NOAA-Unique Combined Atmospheric Processing System (NUCAPS) has been developed by NOAA to routinely process data from future Joint Polar Satellite System operational satellites and the preparatory Suomi-NPP satellite. This paper assesses the NUCAPS vertical temperature profile product from the upper troposphere into the middle stratosphere using radiosonde and GPS radio occultation (RO) data. Radiosonde data from the Department of Energy Atmospheric Radiation Measurement (ARM) program are=] compared to both the NUCAPS and GPS RO temperature products to evaluate bias and RMS errors. At all three fixed ARM sites for time periods investigated the NUCAPS temperature in the 100-40 hPa range is found to have an average bias to the radiosondes of less than 0.45 K and an RMS error of less than 1 K when temperature averaging kernels are applied. At a 95% confidence level, the radiosondes and RO were found to agree within 0.4 K at the North Slope of Alaska site and within 0.83 K at Southern Great Plains and Tropical Western Pacific. The GPS RO-derived dry temperatures, obtained from the University Corporation for Atmospheric Research Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) mission, are used as a common reference for the intercomparison of NUCAPS temperature products to similar products produced by NASA from Atmospheric Infrared Sounder (AIRS) and by European Organisation for the Exploitation of Meteorological Satellites from MetOp-B Infrared Atmospheric Sounding Interferometer (IASI). For seasonal and zonal scales, the NUCAPS agreement with AIRS and IASI is less than 0.5 K after application of averaging kernels.

  6. A Climate Benchmark of Upper Air Temperature Observations from GNSS Radio Occultation

    Science.gov (United States)

    Ao, C. O.; Mannucci, A. J.; Leroy, S. S.; Verkhoglyadova, O. P.

    2017-12-01

    GPS (Global Positioning System), or more generally Global Navigation Satellite System (GNSS), radio occultation (RO) is a remote sensing technique that produces highly accurate temperature in the upper troposphere and lower stratosphere across the globe with fine vertical resolution. Its fundamental measurement is the time delay of the microwave signal as it travels from a GNSS satellite to the receiver in low Earth orbit. With a relatively simple physical retrieval, the uncertainty in the derived temperature can be traced rigorously through the retrieval chain back to the raw measurements. The high absolute accuracy of RO allows these observations to be assimilated without bias correction in numerical weather prediction models and provides an anchor for assimilating other types of observations. The high accuracy, coupled with long-term stability, makes RO valuable in detecting decadal temperature trends. In this presentation, we will summarize the current state of RO observations and show temperature trends derived from 15 years of RO data in the upper troposphere and lower stratosphere. We will discuss our recent efforts in developing retrieval algorithms that are more tailored towards climate applications. Despite the relatively robust "self-calibrating" nature of RO observations, disparity in receiver hardware and software may introduce subtle differences that need to be carefully addressed. While the historic RO data record came from relatively homogeneous hardware based largely on NASA/JPL design (e.g., CHAMP and COSMIC), the future data will likely be comprised of a diverse set of observations from Europe, China, and various commercial data providers. In addition, the use of non-GPS navigation systems will become more prevalent. We will discuss the challenges involved in establishing a long-term RO climate data record from a suite of research and operational weather satellites with changes in instrumentation and coverage.

  7. Isometric stress in cardiovascular magnetic resonance - a simple and easily replicable method of assessing cardiovascular differences not apparent at rest

    Energy Technology Data Exchange (ETDEWEB)

    Mortensen, Kristian H.; Jones, Alexander; Steeden, Jennifer A.; Taylor, Andrew M.; Muthurangu, Vivek [UCL Centre for Cardiovascular MR, UCL Institute of Cardiovascular Science, Level 6 Old Nurses Home, Cardiorespiratory Unit, Great Ormond Street Hospital for Children, London (United Kingdom)

    2016-04-15

    Isometric exercise may unmask cardiovascular disease not evident at rest, and cardiovascular magnetic resonance (CMR) imaging is proven for comprehensive resting assessment. This study devised a simple isometric exercise CMR methodology and assessed the hemodynamic response evoked by isometric exercise. A biceps isometric exercise technique was devised for CMR, and 75 healthy volunteers were assessed at rest, after 3-minute biceps exercise, and 5-minute of recovery using: (1) blood pressure (BP) and (2) CMR measured aortic flow and left ventricular function. Total peripheral resistance (SVR) and arterial compliance (TAC), cardiac output (CO), left ventricular volumes and function (ejection fraction, stroke volume, power output), blood pressure (BP), heart rate (HR), and rate pressure product were assessed at all time points. Image quality was preserved during stress. During exercise there were increases in CO (+14.9 %), HR (+17.0 %), SVR (+9.8 %), systolic BP (+22.4 %), diastolic BP (+25.4 %) and mean BP (+23.2 %). In addition, there were decreases in TAC (-22.0 %) and left ventricular ejection fraction (-6.3 %). Age and body mass index modified the evoked response, even when resting measures were similar. Isometric exercise technique evokes a significant cardiovascular response in CMR, unmasking physiological differences that are not apparent at rest. (orig.)

  8. Isometric stress in cardiovascular magnetic resonance - a simple and easily replicable method of assessing cardiovascular differences not apparent at rest

    International Nuclear Information System (INIS)

    Mortensen, Kristian H.; Jones, Alexander; Steeden, Jennifer A.; Taylor, Andrew M.; Muthurangu, Vivek

    2016-01-01

    Isometric exercise may unmask cardiovascular disease not evident at rest, and cardiovascular magnetic resonance (CMR) imaging is proven for comprehensive resting assessment. This study devised a simple isometric exercise CMR methodology and assessed the hemodynamic response evoked by isometric exercise. A biceps isometric exercise technique was devised for CMR, and 75 healthy volunteers were assessed at rest, after 3-minute biceps exercise, and 5-minute of recovery using: (1) blood pressure (BP) and (2) CMR measured aortic flow and left ventricular function. Total peripheral resistance (SVR) and arterial compliance (TAC), cardiac output (CO), left ventricular volumes and function (ejection fraction, stroke volume, power output), blood pressure (BP), heart rate (HR), and rate pressure product were assessed at all time points. Image quality was preserved during stress. During exercise there were increases in CO (+14.9 %), HR (+17.0 %), SVR (+9.8 %), systolic BP (+22.4 %), diastolic BP (+25.4 %) and mean BP (+23.2 %). In addition, there were decreases in TAC (-22.0 %) and left ventricular ejection fraction (-6.3 %). Age and body mass index modified the evoked response, even when resting measures were similar. Isometric exercise technique evokes a significant cardiovascular response in CMR, unmasking physiological differences that are not apparent at rest. (orig.)

  9. Ultra-High Resolution Orbit Determination of (486958) 2014 MU69: Predicting an Occultation with 1% of an Orbit

    Science.gov (United States)

    Porter, Simon Bernard; Buie, Marc W.; Spencer, John R.; Folkner, William; Parker, Alex; Zangari, Amanda Marie; Verbiscer, Anne J.; Benecchi, Susan; Stern, S. Alan; Terrell, Dirk; Soto, Alejandro; Tamblyn, Peter; Wasserman, Lawrence H.; Young, Eliot F.; New Horizons MU69 Occultation Team

    2017-10-01

    In November 2015, the NASA New Horizons spacecraft burned its thrusters to intercept the cold classical Kuiper Belt Object (486958) 2014 MU69. Then, on July 17, 2017, five small telescopes in Chubut Province, Argentina recorded a solid body occultation of MU69. Both these events required an orbital solution of unprecedented accuracy, as will the January 1, 2019 flyby of MU69 by New Horizons. This was especially difficult because there were no precoveries of MU69 prior to July 2014, it is in an extremely crowded field near the galactic core, and it is faint enough to only be reliably detected by Hubble Space Telescope’s Wide Field Camera 3 (WFC3). To accomplish this, we performed an extremely detailed analysis of 237 WFC3 images, down to the subpixel distortion level, in order to produce individual probability distribution functions (PDFs) for the position of MU69 in each WFC3 image. We registered each WFC3 image against a pre-release version of the Gaia DR2 catalog, which produced even smaller residuals than the now-released DR1. We then combined these WFC3+Gaia PDFs with a high-precision few-body numerical integrator and a Monte Carlo Markov Chain (MCMC) sampler to produce a state vector PDF for MU69 at defined epoch. Propagating those state vectors from the epoch produces an instantaneous positional cloud for MU69 at any given time. This positional cloud was then directly translated into a shadow path uncertainty cloud in order to plan the MU69 occultation campaign. We will describe this process of fully propagating errors from WFC3 images to telescope sites on the ground, and also describe refinements for future guiding of New Horizons to its encounter with MU69. We thank NASA, Hubble, Gaia, CONAE, the city of Comodoro Rivadavia, and the government of Argentina for their assistance and support of the MU69 occultation campaign.

  10. Learning better deep features for the prediction of occult invasive disease in ductal carcinoma in situ through transfer learning

    Science.gov (United States)

    Shi, Bibo; Hou, Rui; Mazurowski, Maciej A.; Grimm, Lars J.; Ren, Yinhao; Marks, Jeffrey R.; King, Lorraine M.; Maley, Carlo C.; Hwang, E. Shelley; Lo, Joseph Y.

    2018-02-01

    Purpose: To determine whether domain transfer learning can improve the performance of deep features extracted from digital mammograms using a pre-trained deep convolutional neural network (CNN) in the prediction of occult invasive disease for patients with ductal carcinoma in situ (DCIS) on core needle biopsy. Method: In this study, we collected digital mammography magnification views for 140 patients with DCIS at biopsy, 35 of which were subsequently upstaged to invasive cancer. We utilized a deep CNN model that was pre-trained on two natural image data sets (ImageNet and DTD) and one mammographic data set (INbreast) as the feature extractor, hypothesizing that these data sets are increasingly more similar to our target task and will lead to better representations of deep features to describe DCIS lesions. Through a statistical pooling strategy, three sets of deep features were extracted using the CNNs at different levels of convolutional layers from the lesion areas. A logistic regression classifier was then trained to predict which tumors contain occult invasive disease. The generalization performance was assessed and compared using repeated random sub-sampling validation and receiver operating characteristic (ROC) curve analysis. Result: The best performance of deep features was from CNN model pre-trained on INbreast, and the proposed classifier using this set of deep features was able to achieve a median classification performance of ROC-AUC equal to 0.75, which is significantly better (p<=0.05) than the performance of deep features extracted using ImageNet data set (ROCAUC = 0.68). Conclusion: Transfer learning is helpful for learning a better representation of deep features, and improves the prediction of occult invasive disease in DCIS.

  11. ACUTE ZONAL OCCULT OUTER RETINOPATHY: Structural and Functional Analysis Across the Transition Zone Between Healthy and Diseased Retina.

    Science.gov (United States)

    Duncker, Tobias; Lee, Winston; Jiang, Fan; Ramachandran, Rithambara; Hood, Donald C; Tsang, Stephen H; Sparrow, Janet R; Greenstein, Vivienne C

    2018-01-01

    To assess structure and function across the transition zone (TZ) between relatively healthy and diseased retina in acute zonal occult outer retinopathy. Six patients (6 eyes; age 22-71 years) with acute zonal occult outer retinopathy were studied. Spectral-domain optical coherence tomography, fundus autofluorescence, near-infrared reflectance, color fundus photography, and fundus perimetry were performed and images were registered to each other. The retinal layers of the spectral-domain optical coherence tomography scans were segmented and the thicknesses of two outer retinal layers, that is, the total receptor and outer segment plus layers, and the retinal nerve fiber layer were measured. All eyes showed a TZ on multimodal imaging. On spectral-domain optical coherence tomography, the TZ was in the nasal retina at varying distances from the fovea. For all eyes, it was associated with loss of the ellipsoid zone band, significant thinning of the two outer retinal layers, and in three eyes with thickening of the retinal nerve fiber layer. On fundus autofluorescence, all eyes had a clearly demarcated peripapillary area of abnormal fundus autofluorescence delimited by a border of high autofluorescence; the latter was associated with loss of the ellipsoid zone band and with a change from relatively normal to markedly decreased or nonrecordable visual sensitivity on fundus perimetry. The results of multimodal imaging clarified the TZ in acute zonal occult outer retinopathy. The TZ was outlined by a distinct high autofluorescence border that correlated with loss of the ellipsoid zone band on spectral-domain optical coherence tomography. However, in fundus areas that seemed healthy on fundus autofluorescence, thinning of the outer retinal layers and thickening of the retinal nerve fiber layer were observed near the TZ. The TZ was also characterized by a decrease in visual sensitivity.

  12. Breast conservation in the setting of contemporary multimodality treatment provides excellent outcomes for patients with occult primary breast cancer.

    Science.gov (United States)

    Rueth, Natasha M; Black, Dalliah M; Limmer, Angela R; Gabriel, Emmanuel; Huo, Lei; Fornage, Bruno D; Dogan, Basak E; Chavez-MacGregor, Mariana; Yi, Min; Hunt, Kelly K; Strom, Eric A

    2015-01-01

    To evaluate recurrence and survival for patients with occult (T0N+) breast cancer who underwent contemporary treatment, assessing outcomes for breast conservation and mastectomy. We performed a single-institution review of women with occult breast cancer presenting with axillary metastasis without identifiable breast tumor or distant metastasis. We excluded patients with tumors in the axillary tail or mastectomy specimen, patients with additional nonbreast cancer diagnoses, and patients with a history of breast cancer. Breast conservation was defined as axillary node dissection with radiation therapy, without breast surgery. We evaluated patient, tumor, treatment, and outcome variables. Patients were assessed for local, regional, and distant recurrences. Overall survival was calculated using the Kaplan-Meier method. Thirty-six patients met criteria for occult breast cancer. Most of these patients (77.8 %) had N1 disease. Fifty percent of cancers (n = 18) were estrogen receptor-positive; 12 (33.3 %) were triple-negative. All patients were evaluated with mammography. Thirty-five patients had breast ultrasound (97.2 %) and 33 (91.7 %) had an MRI. Thirty-four patients (94.4 %) were treated with chemotherapy and 33 (91.7 %) with radiotherapy. Twenty-seven patients (75.0 %) were treated with breast conservation. The median follow-up was 64 months. There were no local or regional failures. One distant recurrence occurred >5 years after diagnosis, resulting in a 5-years overall survival rate of 100 %. There were no significant survival differences between patients receiving breast conservation versus mastectomy (p = 0.7). Breast conservation-performed with contemporary imaging and multimodality treatment-provides excellent local control and survival for women with T0N+ breast cancer and can be safely offered instead of mastectomy.

  13. Symptoms of thyrotoxicosis, bone metabolism and occult atrial fibrillation in older women with mild endogenous subclinical hyperthyroidism.

    Science.gov (United States)

    Rosario, Pedro Weslley; Carvalho, Marina; Calsolari, Maria Regina

    2016-07-01

    The objective of this study was to evaluate symptoms of thyrotoxicosis, bone turnover, bone mineral density (BMD) and occult atrial fibrillation (AF) in women ≥65 years with mild endogenous subclinical hyperthyroidism (SCH). Cross-sectional and case-control study. Signs and symptoms of thyrotoxicosis, serum carboxyterminal telopeptide (CTx) and procollagen type I N-terminal propeptide (PINP), BMD, resting electrocardiogram (ECG) and 72-h ECG monitoring were evaluated in 180 women ≥65 years, including 90 with mild SCH (TSH between 0·1 and 0·4 mIU/l) and 90 euthyroid controls matched for age and body mass index. Symptom Rating Scale scores did not differ between patients and controls. None of the patients with SCH scored 20 points, a score compatible with clinical thyrotoxicosis. Eighty patients with SCH (89%) obtained seven or fewer points, a score compatible with euthyroidism. No difference in serum CTx or PINP concentrations was observed between patients and controls. There was also no correlation between these markers and TSH, free T4 or total T3 levels. Finally, no difference in femoral neck or lumbar spine BMD was observed between patients with SCH and controls. Three patients with SCH (3·3%) and two euthyroid women (2·2%) had known AF or AF in the resting ECG. ECG monitoring for 72 h revealed episodes of occult AF in 1/87 patients with SCH and in 1/88 euthyroid women (1·1%). Mild endogenous SCH (TSH between 0·1 and 0·4 mIU/l) was not associated with symptoms of thyrotoxicosis, altered bone metabolism or a higher prevalence of occult AF in women ≥65 years. © 2015 John Wiley & Sons Ltd.

  14. Radio occultation studies of the Venus atmosphere with the Magellan spacecraft. 2: Results from the October 1991 experiments

    Science.gov (United States)

    Jenkins, Jon M.; Steffes, Paul G.; Hinson, David P.; Twicken, Joseph D.; Tyler, G. Leonard

    1994-01-01

    On October 5 and 6, 1991, three dual-frequency ingress radio occultation experiments were conducted at Venus during consecutive orbits of the Magellan spacecraft. The radio signals probed a region of the atmosphere near 65 deg N, with a solar zenith angle of 108 deg, reaching below 35 km at 3.6 cm, and below 34 km at 13 cm (above a mean radius of 6052 km). The high effective isotropic radiated power (EIRP) of the Magellan spacecraft and highly successful attitude maneuvers allowed these signals to probe deeper than any previous radio occultation experiment and also resulted in the most accurate thermal and sulfuric acid vapor abundance profiles ever obtained at Venus through radio occultation techniques. The performance of the spacecraft and the experiment design are discussed in an accompanying paper. Average electron density profiles retrieved from the data possess peaks between 2600 and 6000/cu cm, well below typical values of 10,000/cu cm retrieved in 1979 by Pioneer Venus at similar solar zenith angles. Other basic results include vertical profiles of temperature, pressure, and density in the neutral atmosphere, 13- and 3.6-cm absorpttivity, and H2SO4 (g) abundance below the main cloud layer. H2SO4 (g) becomes significant below 50 km, reaching peaks between 18 and 24 ppm near 39 km before dropping precipitously below 38 km. These sharp decreases confirm the thermal decomposition of sulfuric acid vapor below 39 km. Since the Venus atmosphere rotated approximately 10 deg between experiments, the data contain information about the horizontal variability of the atmosphere. All derived profiles exhibit significant variations from orbit to orbit, indicating the presence of dynamical processes between 33 and 200 km. In particular, the orbit-to-orbit variations in temperature and in H2SO4 (g) abundance appear to be correlated, suggesting that a common mechanism may be responsible for the observed spatial variations.

  15. Poster 7: Could PAH or HAC explain the Titan's stratosphere absorption around 3.4 µm revealed by solar occultations?

    Science.gov (United States)

    Cordier, Daniel; Cours, Thibaud; Rey, Michael; Maltagliati, Luca; Seignovert, Benoit; Biennier, Ludovic

    2016-06-01

    In 2006, during Cassini's 10th flyby of Titan (T10), Bellucci et al. (2009) observed a solar occultation by Titan's atmosphere through the solar port of the Cassini/VIMS instrument. These authors noticed the existence of an unexplained additional absorption superimposed to the CH4 3.3 µm band. Because they were unable to model this absorption with gases, they attributed this intriguing feature to the signature of solid state organic components. Kim et al. (2011) revisited the data collected by Bellucci et al. (2009) and they considered the possible contribution of aerosols formed by hydrocarbon ices. They specifically took into account C2H6, CH4, CH3CN, C5H12 and C6H12 ices. More recently, Maltagliati et al. (2015) analyzed a set of four VIMS solar occultations, corresponding to flybys performed between January 2006 and September 2011 at different latitudes. They confirmed the presence of the 3.3 µm absorption in all occultations and underlined the possible importance of gaseous ethane, which has a strong plateau of absorption lines in that wavelength range.In this work, we show that neither hydrocarbon ices nor molecular C2H6 cannot satisfactorily explain the observed absorption. Our simulations speak in favor of an absorption due to the presence of PAH molecules or HAC in the stratosphere of Titan. PAH have been already considered by Lopes-Puertas et al. (2013) at altitudes larger than ˜900 km and tentatively identified in the stratosphere by Maltagliati et al. (2015); PAH and HAC are good candidates for Titan's aerosols precursors.

  16. Nuclear stress test

    Science.gov (United States)

    ... Persantine stress test; Thallium stress test; Stress test - nuclear; Adenosine stress test; Regadenoson stress test; CAD - nuclear stress; Coronary artery disease - nuclear stress; Angina - nuclear ...

  17. Risk stratification and detection of new colorectal neoplasms after colorectal cancer screening with faecal occult blood test

    DEFF Research Database (Denmark)

    Bjerrum, Andreas; Milter, Maya Christel; Andersen, Ole

    2015-01-01

    BACKGROUND: Limited data exist on adenoma surveillance as recommended in the European guidelines for quality assurance in colorectal cancer (CRC) screening and diagnosis after faecal occult blood test (FOBT) screening. OBJECTIVE: To assess the European guidelines for adenoma surveillance after CRC...... of CRC was higher in risk group C than A (RR 5.20, 95% confidence interval: 0.63-42.58), but not statistically significant. In risk group C, half of new advanced adenomas were detected within the first year and four of nine CRC were detected within 3 years. CONCLUSION: Risk stratification of adenoma...

  18. Genomic variability associated with the presence of occult hepatitis B virus in HIV co-infected individuals

    OpenAIRE

    Martin, C. M.; Welge, J. A.; Shire, N. J.; Rouster, S. D.; Shata, M. T.; Sherman, K. E.; Blackard, J. T.

    2009-01-01

    Occult hepatitis B virus (O-HBV) infection is characterized by the presence of HBV DNA without detectable hepatitis B surface antigen (HBV DNA+/HBsAg−) in the serum. Although O-HBV is more prevalent during HBV/HIV co-infection, analysis of HBV mutations in co-infected patients is limited. In this preliminary study, HBV PreSurface (PreS) and surface (S) regions were amplified from 33 HIV-positive patient serum samples − 27 chronic HBV (C-HBV) and six O-HBV infections. HBV genotype was determin...

  19. Occultations from an Active Accretion Disk in a 72-day Detached Post-Algol System Detected by K2

    DEFF Research Database (Denmark)

    Zhou, G.; Rappaport, S.; Nelson, L.

    2018-01-01

    Disks in binary systems can cause exotic eclipsing events. MWC 882 (BD –22 4376, EPIC 225300403) is such a disk-eclipsing system identified from observations during Campaign 11 of the K2 mission. We propose that MWC 882 is a post-Algol system with a B7 donor star of mass in a 72-day orbit around...... an A0 accreting star of mass . The disk around the accreting star occults the donor star once every orbit, inducing 19-day long, 7% deep eclipses identified by K2 and subsequently found in pre-discovery All-Sky Automated Survey and All Sky Automated Survey for Supernovae observations. We coordinated...

  20. Design and construction of a 76m long-travel laser enclosure for a space occulter testbed

    Science.gov (United States)

    Galvin, Michael; Kim, Yunjong; Kasdin, N. Jeremy; Sirbu, Dan; Vanderbei, Robert; Echeverri, Dan; Sagolla, Giuseppe; Rousing, Andreas; Balasubramanian, Kunjithapatham; Ryan, Daniel; Shaklan, Stuart; Lisman, Doug

    2016-07-01

    Princeton University is upgrading our space occulter testbed. In particular, we are lengthening it to 76m to achieve flightlike Fresnel numbers. This much longer testbed required an all-new enclosure design. In this design, we prioritized modularity and the use of commercial off-the-shelf (COTS) and semi-COTS components. Several of the technical challenges encountered included an unexpected slow beam drift and black paint selection. Herein we describe the design and construction of this long-travel laser enclosure.