45 CFR 2400.1 - Purposes.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purposes. 2400.1 Section 2400.1 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION FELLOWSHIP PROGRAM REQUIREMENTS General § 2400.1 Purposes. (a) The purposes of the James Madison Memorial Fellowship...

45 CFR 50.1 - Authority.

Science.gov (United States)

2010-10-01

... WAIVER OF THE TWO-YEAR FOREIGN RESIDENCE REQUIREMENT § 50.1 Authority. Under the authority of Mutual... 45 Public Welfare 1 2010-10-01 2010-10-01 false Authority. 50.1 Section 50.1 Public Welfare... Government agency” with the authority to request the Department of State to recommend to the Attorney General...

45 CFR 1219.1 - Introduction.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Introduction. 1219.1 Section 1219.1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE COMPETITIVE SERVICE ELIGIBILITY § 1219.1 Introduction. Section 415(d), Title IV, of the Domestic Volunteer Service Act...

45 CFR 1218.1 - Introduction.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Introduction. 1218.1 Section 1218.1 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE VISTA VOLUNTEERS-HEARING OPPORTUNITY § 1218.1 Introduction. Section 104(d) of the Domestic Volunteer Service Act of...

45 CFR 605.1 - Purpose.

Science.gov (United States)

2010-10-01

... OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 605.1 Purpose. The purpose of this part is to effectuate section 504 of the Rehabilitation Act of 1973... 45 Public Welfare 3 2010-10-01 2010-10-01 false Purpose. 605.1 Section 605.1 Public Welfare...

45 CFR 1232.1 - Purpose.

Science.gov (United States)

2010-10-01

... NONDISCRIMINATION ON BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE General Provisions § 1232.1 Purpose. The purpose of this part is to effectuate section 504 of the Rehabilitation Act... 45 Public Welfare 4 2010-10-01 2010-10-01 false Purpose. 1232.1 Section 1232.1 Public Welfare...

Ordered perovskites with cationic vacancies. 3. Ba/sub 2/CeSbsub(4/5)vacantsub(1/5)O/sub 6/, the first representant of a new perovskite variant

Energy Technology Data Exchange (ETDEWEB)

Rauser, G; Kemmler-Sack, S [Tuebingen Univ. (Germany, F.R.). Inst. fuer Chemie

1978-11-01

The lemon coloured Ba/sub 2/CeSbsub(4/5)vacantsub(1/5)O/sub 6/ is polymorphic. The HT modification has a cubic face centered (a = 8.53 A) and the TT form a cubic primitive lattice (a = 8.53 A). According to the density measurement there are 4 formula units of Ba/sub 2/CeSbsub(4/5)vacantsub(1/5)O/sub 6/ in the unit cell.

Volcanism at 1.45 Ma within the Yellowstone Volcanic Field, United States

Science.gov (United States)

Rivera, Tiffany A.; Furlong, Ryan; Vincent, Jaime; Gardiner, Stephanie; Jicha, Brian R.; Schmitz, Mark D.; Lippert, Peter C.

2018-05-01

Rhyolitic volcanism in the Yellowstone Volcanic Field has spanned over two million years and consisted of both explosive caldera-forming eruptions and smaller effusive flows and domes. Effusive eruptions have been documented preceding and following caldera-forming eruptions, however the temporal and petrogenetic relationships of these magmas to the caldera-forming eruptions are relatively unknown. Here we present new 40Ar/39Ar dates for four small-volume eruptions located on the western rim of the second-cycle caldera, the source of the 1.300 ± 0.001 Ma Mesa Falls Tuff. We supplement our new eruption ages with whole rock major and trace element chemistry, Pb isotopic ratios of feldspar, and paleomagnetic and rock magnetic analyses. Eruption ages for the effusive Green Canyon Flow (1.299 ± 0.002 Ma) and Moonshine Mountain Dome (1.302 ± 0.003 Ma) are in close temporal proximity to the eruption age of the Mesa Falls Tuff. In contrast, our results indicate a period of volcanism at ca 1.45 Ma within the Yellowstone Volcanic Field, including the eruption of the Bishop Mountain Flow (1.458 ± 0.002 Ma) and Tuff of Lyle Spring (1.450 ± 0.003 Ma). These high-silica rhyolites are chemically and isotopically distinct from the Mesa Falls Tuff and related 1.3 Ma effusive eruptions. The 40Ar/39Ar data from the Tuff of Lyle Spring demonstrate significant antecrystic inheritance, prevalent within the upper welded ash-flow tuff matrix, and minimal within individual pumice. Antecrysts are up to 20 kyr older than the eruption, with subpopulations of grains occurring every few thousand years. We interpret these results as an indicator for the timing of magmatic pulses into a growing magmatic system that would ultimately erupt the Tuff of Lyle Spring, and which we more broadly interpret as the tempo of crustal accumulation associated with bimodal magmatism. We propose a system whereby chemically, isotopically, and temporally distinct, isolated small-volume magma batches are

45 CFR 73b.1 - Scope.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope. 73b.1 Section 73b.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DEBARMENT OR SUSPENSION OF FORMER EMPLOYEES... officer or employee of the Department, including former and retired officers of the commissioned corps of...

Effects of 45Ca on murine skeletal muscle. 1

International Nuclear Information System (INIS)

Asotra, K.; Katoch, S.S.; Krishan, K.; Malhotra, R.K.

1983-01-01

Adult Swiss albino mice weighing 16+-1 g were injected with 3.7x10 4 Bq and 7.4x10 4 Bq/g body weight of 45 Ca. Mice of both dose groups were autopsied on days 1, 3, 5, 7, 14 and 28 after 45 Ca administration. Diaphragm and gastrocnemius in the 45 Ca-treated and normal mice were analyzed for quantitation of glycogen as well as bioassay of phosphorylase and phosphohexose isomerase activities. Internal irradiation with the two doses of 45 Ca resulted in glycogen accumulation in both the muscles. 45 Ca-treated diaphragm showed greater radioresponse but a slower recovery than gastrocnemius with respect to glycogen accumulation. A decline in the rates of glycogenolysis and glycolysis indicated by decreased phosphorylase and phosphohexose isomerase activities appeared to be responsible for glycogen accumulation in skeletal muscle on account of 45 Ca treatment. (author)

HMB-45, S-100, NK1/C3, and MART-1 in metastatic melanoma.

Science.gov (United States)

Zubovits, Judit; Buzney, Elizabeth; Yu, Lawrence; Duncan, Lyn M

2004-02-01

The diagnosis of melanoma metastatic to lymph node remains a difficult problem given its histological diversity. We examined the staining patterns of S-100, NK1/C3, HMB-45, and MART-1 (DC10) in melanoma metastases to lymph nodes. Immunohistochemical stains were performed on tissue sections of 126 formalin-fixed lymph nodes from 126 patients with an established diagnosis of metastatic melanoma. A total of 98% of cases (123 of 126) stained positive for S-100, 93% (117 of 125) stained positive for NK1/C3, 82% (103 of 126) stained positive for MART-1, and 76% (95 of 125) stained positive for HMB-45. The distribution and intensity of staining varied among these markers. A diffuse staining pattern, defined as >50% of tumor cells stained, was observed in 83% of MART-1-positive cases but in only 56% of S-100-positive cases, 48% of NK1/C3-positive cases, and 34% of HMB-45-positive cases. A maximally intense signal was almost always observed for MART-1 (83% of positive cases) but was rarely observed for NK1/C3 (20%). S-100 and HMB-45 showed maximally intense staining in 50% and 54% of cases, respectively. S-100 and NK1/C3 stained both histiocytes and melanocytes, whereas MART-1 and HMB-45 stained only melanocytes. Seventy-eight cases (63%) stained positive for all 4 markers, 17 cases (14%) stained for all markers except HMB-45, 13 cases (10%) stained for all markers except MART-1, 6 cases (5%) stained only with S-100 and NK1/C3, 4 cases (3%) stained only with S-100 and HMB-45, and 2 cases stained for all markers except S-100. One case each stained for the following: only S-100, only S-100 and HMB-45, and all markers except NK1/C3. One case exhibited absence of staining for any of these markers. We demonstrate that lymph node metastases of melanoma are heterogeneous with regard to tumor marker expression. S-100 and NK1/C3 were the most sensitive stains for detecting metastatic melanoma; however, they both also stain other nontumor cells in lymph nodes. MART-1 did not stain

Audit Calculations of ATWS for Ulchin Unit 1 and 2 Power Uprate

Energy Technology Data Exchange (ETDEWEB)

Lee, Jun Soo; Huh, Byung Gil; Choi, Yong Seog; Seul, Kwang Won [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2013-10-15

In this study, the regulatory audit calculation for ATWS of Ulchin Unit 1 and 2 with 4.5% power uprate was performed to support the licensing review and to confirm the validity of licensee's calculation. In order to simulate the transient behavior of ATWS initiated by a loss of feed water, the systems of Ulchin Unit 1 and 2 was modeled with MARS-KS 1.3. In this study, the regulatory audit calculation of ATWS for Ulchin 1 and 2 with 4.5% power uprating and 99% MTC in the specific cycle designs was performed. It is conformed that the analysis results of ATWS for Ulchin 1 and 2 power uprate meets the RCS pressure acceptance criteria. An anticipated transient accompanied by a failure in the Reactor Trip System (RTS) to shut down the reactor is defined as an Anticipated Transient Without Scram (ATWS). Under certain postulated conditions, the ATWS could lead to Reactor Coolant system (RCS) pressure boundary fracture and/or core damage. For a conventional pressurized water reactor (PWR), the temperature corresponding to the NSSC notice No.2013.09(Performance Criteria for ECCS of the Pressurized Water Reactor Nuclear Power Plants), 1204 .deg. C and the pressure corresponding to the ASME Boiler and Pressure Vessel Code service level C stress, 221.5 bar is assumed to be an unacceptable plant condition against ATWS, above which the RCS pressure boundary could deform to the point of inoperability and the safe shutdown by injection of borated water could be challenged. Such potentially excessive RCS overpressure may occur in the ATWS initiated from a loss of heat sink. Currently, the modification of Ulchin 1 and 2 operating license for 4.5% power uprate is under review.

45 CFR 63.1 - Purpose and scope.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Purpose and scope. 63.1 Section 63.1 Public... OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION General § 63.1 Purpose and scope. (a... analyses, and demonstrations and evaluations which have demonstrated a high probability of impacting on the...

45 CFR 99.1 - Scope of rules.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Scope of rules. 99.1 Section 99.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE CHILD CARE AND DEVELOPMENT FUND General § 99.1 Scope of rules. (a) The rules of procedure in this section govern the practice...

A Cryogenic Test Station for the Pre-series 2400 W @ 1.8 K Refrigeration Units for the LHC

CERN Document Server

Claudet, S; Gully, P; Jäger, B; Millet, F; Roussel, P; Tavian, L

2002-01-01

The cooling capacity below 2 K for the superconducting magnets in the Large Hadron Collider (LHC), at CERN, will be provided by eight refrigeration units at 1.8 K, each of them coupled to a 4.5 K refrigerator. The supply of the series units is linked to successful testing and acceptance of the pre-series delivered by the two selected vendors. To properly assess the performance of specific components such as cold compressors and some process specificities a dedicated test station is necessary. The test station is able to process up to 130 g/s between 4.5 & 20 K and aims at simulating the steady and transient operational modes foreseen for the LHC. After recalling the basic characteristics of the 1.8 K refrigeration units and the content of the acceptance tests of the pre-series, the principle of the test cryostat is detailed. The components of the test station and corresponding layout are described. The first testing experience is presented as well as preliminary results of the pre-series units.

26 CFR 1.45G-1 - Railroad track maintenance credit.

Science.gov (United States)

2010-04-01

... TAXES Rules for Computing Credit for Investment in Certain Depreciable Property § 1.45G-1 Railroad track... extensions) Federal income tax return for the taxable year the RTMC is claimed. Paragraph (b) of this section..., accounting and bookkeeping, marketing, legal services; janitorial services; office building rental; banking...

46 CFR 105.45-1 - Loading or dispensing petroleum products.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Loading or dispensing petroleum products. 105.45-1... VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Special Operating Requirements § 105.45-1 Loading or dispensing petroleum products. (a) A commercial fishing vessel must have aboard a letter of...

Aqua(4-hydroxypyridine-2,6-dicarboxylato(1,10-phenanothrolinecopper(II 4.5-hydrate

Directory of Open Access Journals (Sweden)

Hossein Aghabozorg

2008-01-01

Full Text Available The title compound, [Cu(C7H3NO5(C12H8N2(H2O]·4.5H2O or [Cu(hypydc(phen(H2O]·4.5H2O (phen is 1,10-phenanthroline and hypydcH2 is 4-hydroxypyridine-2,6-dicarboxylic acid, was obtained by the reaction of copper(II nitrate hexahydrate with the proton-transfer compound (phenH2(hypydc in aqueous solution. Both the cationic and the anionic fragments of the proton-transfer compound are involved in complexation. Each CuII atom has a distorted octahedral geometry. It is hexacoordinated by three O atoms and three N atoms, from one phen fragment (as bidentate ligand, one (hypydc2− unit (as tridentate ligand and a water molecule. In the crystal structure, O—H...O and C—H...O hydrogen bonds, and π–π stacking interactions [centroid-to-centroid distance 3.5642 (11 Å] between the phen ring systems, contribute to the formation of a three-dimensional supramolecular structure.

46 CFR 196.45-1 - Master and chief engineer responsible.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Master and chief engineer responsible. 196.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 196.45-1 Master and chief engineer responsible. (a) It shall be the duty of the master and the engineer in charge of the boilers of any vessel to require that a...

46 CFR 97.45-1 - Master and chief engineer responsible.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Master and chief engineer responsible. 97.45-1 Section... VESSELS OPERATIONS Carrying of Excess Steam § 97.45-1 Master and chief engineer responsible. It shall be the duty of the master and the chief engineer of any vessel to require that a steam pressure is not...

45 CFR 84.45 - Housing.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Housing. 84.45 Section 84.45 Public Welfare... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 84.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall...

Dynamic simulation of a 1.8K refrigeration unit for the LHC

CERN Document Server

Bradu, B; Niculescu, S I

2009-01-01

A new simulation toolkit has been successfully developed at the European Organization for Nuclear Research (CERN) and applied to existing cryogenic installations as, for example, the 1.3kW @ 4.5K cold-box of the Compact Muon Solenoid (CMS) experiment and the central CERN helium liquefier. The simulator is based on different interconnected simulation tools and provides simulations of cryogenic systems with their control and supervision. In this paper, we present an application to a complete 2.4kW @ 1.8K refrigeration unit for the LHC. It includes the cryogenic centrifugal compressors coupled to the warm compression station.

A novel role for Gadd45α in base excision repair: Modulation of APE1 activity by the direct interaction of Gadd45α with PCNA

International Nuclear Information System (INIS)

Kim, Hye Lim; Kim, Sang Uk; Seo, Young Rok

2013-01-01

Highlights: ► Emerging critical role for Gadd45α in modulating BER activity. ► Identifying specific PCNA binding site on Gadd45α protein. ► Regulating APE1 activity through interaction between Gadd45α and PCNA. ► Suggesting potential role of Gadd45α–PCNA binding in pancreatic carcinogenesis. -- Abstract: The growth arrest and DNA damage inducible, alpha (Gadd45α) protein regulates DNA repair by interacting with proliferating cell nuclear antigen (PCNA). Our previous study suggested a potential role for Gadd45α in the base excision repair (BER) pathway by affecting apurinic/apyrimidinic endonuclease 1 (APE1) protein in addition to its accepted role in nucleotide excision repair (NER). Here, we investigated whether the interaction of Gadd45α with PCNA affects APE1 activity. To address this issue, we used a siRNA directed to Gadd45α and a form of Gadd45α with a mutation to the predicted site of PCNA binding. There was a reduction of APE1 activity in cells transfected with the Gadd45α siRNA. Furthermore, the interaction of Gadd45α with PCNA and APE1 was lower in cells transfected with mutant Gadd45α compared with cells transfected with wild-type Gadd45α. Indeed, we observed that the APE1 activity in the Gadd45α-interacting complex was significantly lower in cells that overexpress mutant Gadd45α compared with cells that overexpress wild-type Gadd45α. We conclude that the PCNA binding site on Gadd45α plays a critical role in modulating the interaction with PCNA and APE1, affecting BER activity. These results provide novel insights into the mechanisms by which BER activity is modulated, although the interaction of Gadd45α with APE1 needs to be clarified

DNA Fragmentation Factor 45 (DFF45 Gene at 1p36.2 Is Homozygously Deleted and Encodes Variant Transcripts in Neuroblastoma Cell Line

Directory of Open Access Journals (Sweden)

Hong Wei Yang

2001-01-01

Full Text Available Recently, loss of heterozygosity (LOH studies suggest that more than two tumor suppressor genes lie on the short arm of chromosome 1 (1p in neuroblastoma (NB. To identify candidate tumor suppressor genes in NB, we searched for homozygous deletions in 20 NB cell lines using a high-density STS map spanning chromosome 1 p36, a common LOH region in NB. We found that the 45-kDa subunit of the DNA fragmentation factor (DFF45 gene was homozygously deleted in an NB cell line, NB-1. DFF45 is the chaperon of DFF40, and both molecules are necessary for caspase 3 to induce apoptosis. DFF35, a splicing variant of DFF45, is an inhibitor of DFF40. We examined 20 NB cell lines for expression and mutation of DFF45 gene by reverse transcription (RT-polymerase chain reaction (PCR and RT-PCR-single-strand conformation polymorphism. Some novel variant transcripts of the DFF45 gene were found in NB cell lines, but not in normal adrenal gland and peripheral blood. These variants may not serve as chaperons of DFF40, but as inhibitors like DFF35, thus disrupting the balance between DFF45 and DFF40. No mutations of the DFF45 gene were found in any NB cell line, suggesting that the DFF45 is not a tumor suppressor gene for NB. However, homozygous deletion of the DFF45 gene in the NB-1 cell line may imply the presence of unknown tumor suppressor genes in this region.

Cloning, overexpression, purification, crystallization and preliminary X-ray analysis of 3-ketosteroid Δ{sup 4}-(5α)-dehydrogenase from Rhodococcus jostii RHA1

Energy Technology Data Exchange (ETDEWEB)

Oosterwijk, Niels van; Knol, Jan; Dijkhuizen, Lubbert; Geize, Robert van der; Dijkstra, Bauke W., E-mail: b.w.dijkstra@rug.nl [University of Groningen, Nijenborgh 7, 9747 AG Groningen (Netherlands)

2011-10-01

The gene for 3-ketosteroid Δ{sup 4}-(5α)-dehydrogenase from R. jostii RHA1 was cloned and overexpressed in E. coli and the protein product was purified and crystallized using the hanging-drop vapour-diffusion method. The crystals belonged to space group C222{sub 1} and diffraction data were collected to a resolution of 1.6 Å. 3-Ketosteroid dehydrogenases are flavoproteins which play key roles in steroid ring degradation. The enzymes are abundantly present in actinobacteria, including the catabolic powerhouse Rhodococcus jostii and the pathogenic species R. equi and Mycobacterium tuberculosis. The gene for 3-ketosteroid Δ{sup 4}-(5α)-dehydrogenase [Δ{sup 4}-(5α)-KSTD] from R. jostii RHA1 was cloned and overexpressed in Escherichia coli. His-tagged Δ{sup 4}-(5α)-KSTD enzyme was purified by Ni{sup 2+}–NTA affinity chromatography, anion-exchange chromatography and size-exclusion chromatography and was crystallized using the hanging-drop vapour-diffusion method. Seeding greatly improved the number of crystals obtained. The crystals belonged to space group C222{sub 1}, with unit-cell parameters a = 99.2, b = 114.3, c = 110.2 Å. Data were collected to a resolution of 1.6 Å.

45 CFR 60.1 - The National Practitioner Data Bank.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false The National Practitioner Data Bank. 60.1 Section 60.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NATIONAL PRACTITIONER DATA BANK FOR ADVERSE INFORMATION ON PHYSICIANS AND OTHER HEALTH CARE PRACTITIONERS General...

8 CFR 1240.45 - Postponement and adjournment of hearing.

Science.gov (United States)

2010-01-01

.... 1240.45 Section 1240.45 Aliens and Nationality EXECUTIVE OFFICE FOR IMMIGRATION REVIEW, DEPARTMENT OF JUSTICE IMMIGRATION REGULATIONS PROCEEDINGS TO DETERMINE REMOVABILITY OF ALIENS IN THE UNITED STATES Proceedings To Determine Deportability of Aliens in the United States: Hearing and Appeal (for Proceedings...

Synthesis and characterization of copolymers 4,5-dihydroisoxazole and (-)-menthyl acrylates; Sintese e caracterizacao de copolimeros de cadeia lateral derivados de acrilatos de 4,5-di-hidroisoxazol e do (-)-mentol

Energy Technology Data Exchange (ETDEWEB)

Passo, Joel A.; Merlo, Aloir A. [Universidade Federal do Rio Grande do Sul, Porto Alegre, RS (Brazil). Inst. de Quimica; Eccher, Juliana; Bechtold, Ivan H. [Universidade Federal de Santa Catarina, Florianopolis, SC (Brazil). Campus Universitario Trindade. Dept. de Fisica; Kelly, Stephen M., E-mail: aloir@iq.ufrgs.br [University of Hull, Hull (United Kingdom). Dept. of Chemistry

2012-07-01

Five monomers 5-[4-(5-cyano-4,5-dihydroisoxazol-3-yl)phenoxy]undecyl acrylate (7a); n-alkyl 3-{l_brace}4-[5-(acryloyloxyundecyl)oxyphenyl]{r_brace}-4,5-dihydroisoxazole-5-carboxylate (7b,c for n-butyl and n-hexyl, respectively); 3-{l_brace}4-[5-(acryloyloxyundecyl) oxyphenyl]{r_brace}-4,5-dihydroisoxazole-5-carboxylic acid (7d) and (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl acrylate (9) and the corresponding copolymers 10a-d,11 and homopolymers 12 from 7a and 13 from 9 were designed and synthesized. Except for acrylate 9 which is derived from (-)-menthol, all of the monomers belong to the series containing the isoxazoline ring linked to the acrylate unit by a flexible spacer chain of eleven methylene units. They presented low glass temperature and despite birefringence behavior, these copolymers showed no mesomorphic properties. (author)

Steam generator replacement in Bruce A Unit 1 and Unit 2

International Nuclear Information System (INIS)

Hart, R.S.

2006-01-01

The Bruce A Generating Station consists of four 900 MW class CANDU units. The reactor and Primary Heat Transport System for each Unit are housed within a reinforced concrete reactor vault. A large duct running below the reactor vaults accommodates the shared fuel handling system, and connects the four reactor vaults to the vacuum building. The reactor vaults, fuelling system duct and the vacuum building constitute the station vacuum containment system. Bruce A Unit 2 was shut down in 1995 and Bruce A Units 1, 3 and 4 were shutdown in 1997. Bruce A Units 3 and 4 were returned to service in late 2003 and are currently operating. Units 1 and 2 remain out of service. Bruce Power is currently undertaking a major rehabilitation of Bruce A Unit 1 and Units 2 that will extend the in-service life of these units by at least 25 years. Replacement of the Steam Generators (eight in each unit) is required; this work was awarded to SNC-Lavalin Nuclear (SLN). The existing steam drums (which house the steam separation and drying equipment) will be retained. Unit 2 is scheduled to be synchronized with the grid in 2009, followed by Unit 1 in 2009. Each Bruce A unit has two steam generating assemblies, one located above and to each end of the reactor. Each steam generating assembly consists of a horizontal cylindrical steam drum and four vertical Steam Generators. The vertical Steam Generators connect to individual nozzles that are located on the underside of the Steam Drum (SD). The steam drums are located in concrete shielding structures (steam drum enclosures). The lower sections of the Steam Generators penetrate the top of the reactor vaults: the containment pressure boundary is established by bellows assemblies that connect between the reactor vault roof slab and the Steam Generators. Each Steam Generators is supported from the bottom by a trapeze that is suspended from the reactor vault top structure. The Steam Generator Replacement (SGR) methodology developed by SLN for Unit 1

A Novel Extended N-Methyl Monopyrrolotetrathiafulvalene Based on 2-Methylene-4,5-Bis(Methylthio-1,3-Dithiole

Directory of Open Access Journals (Sweden)

Ruibin Hou

2014-12-01

Full Text Available The title compound was prepared via a cross-coupling reaction and its crystal structure has been determined. It crystallized in the triclinic space group P-1 with cell parameters: a = 8.552(2 Å, b = 11.310(2 Å, c = 16.150(3 Å, α = 109.55(3°, β = 91.45(3°, γ = 91.28(3°, V = 1470.6(5 Å3, Z = 2 at 296 K. There is one molecule in the asymmetric unit. In the crystal structure, the neighboring molecules from dimers by weak intermolecular π···π interactions between the pyrrole and tetrathiafulvalene units. The dimers are further linked through C-H···π interactions to generate one-dimensional chains along the [100] direction. The arrangement of the molecules corresponds to an overlap between the HOMO and LUMO.

A Study To Determine the Feasibility of Converting the Audio Magazine Program of NLS/BPH from Flexible Disk to Cassette Format. Draft Report.

Science.gov (United States)

ManTech Advanced Technology Systems, Fairfax, VA.

This report contains the results of a study sponsored by the National Library Service for the Blind and Physically Handicapped to investigate the implications of converting its audio magazine program from flexible disk to audiocassette. Specific issues to be considered included whether or not such a conversion would represent: (1) a financial…

Synthesis and characterization of copolymers 4,5-dihydroisoxazole and (-)-menthyl acrylates

International Nuclear Information System (INIS)

Passo, Joel A.; Merlo, Aloir A.; Eccher, Juliana; Bechtold, Ivan H.; Kelly, Stephen M.

2012-01-01

Five monomers 5-[4-(5-cyano-4,5-dihydroisoxazol-3-yl)phenoxy]undecyl acrylate (7a); n-alkyl 3-{4-[5-(acryloyloxyundecyl)oxyphenyl]}-4,5-dihydroisoxazole-5-carboxylate (7b,c for n-butyl and n-hexyl, respectively); 3-{4-[5-(acryloyloxyundecyl) oxyphenyl]}-4,5-dihydroisoxazole-5-carboxylic acid (7d) and (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl acrylate (9) and the corresponding copolymers 10a-d,11 and homopolymers 12 from 7a and 13 from 9 were designed and synthesized. Except for acrylate 9 which is derived from (-)-menthol, all of the monomers belong to the series containing the isoxazoline ring linked to the acrylate unit by a flexible spacer chain of eleven methylene units. They presented low glass temperature and despite birefringence behavior, these copolymers showed no mesomorphic properties. (author)

45 CFR 4.5 - Effect of regulations.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Effect of regulations. 4.5 Section 4.5 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION SERVICE OF PROCESS § 4.5 Effect of regulations. The regulations in this part are intended solely to identify Department officials who are...

45 CFR 1155.665 - State.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false State. 1155.665 Section 1155.665 Public Welfare...) Definitions § 1155.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

45 CFR 1173.665 - State.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false State. 1173.665 Section 1173.665 Public Welfare...) Definitions § 1173.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or possession of the United States. ...

1:250,000-scale Hydrologic Units of the United States

Science.gov (United States)

Steeves, Peter; Nebert, Douglas

1994-01-01

The Geographic Information Retrieval and Analysis System (GIRAS) was developed in the mid 70s to put into digital form a numberof data layers which were of interest to the USGS. One of these data layers was the Hydrologic Units. The map is based on the Hydrologic Unit Maps published by the U.S. Geological Survey Office of Water Data Coordination, together with the list descriptions and name of region, subregion, accounting units, and cataloging unit. The hydrologic units are encoded with an eight-digit number that indicates the hydrologic region (first two digits), hydrologic subregion (second two digits), accounting unit (third two digits), and cataloging unit (fourth two digits). The data produced by GIRAS was originally collected at a scale of 1:250K. Some areas, notably major cities in the west, were recompiled at a scale of 1:100K. In order to join the data together and use the data in a geographic information system (GIS) the data were processed in the ARC/INFO GUS software package. Within the GIS, the data were edgematched and the neatline boundaries between maps were removed to create a single data set for the conterminous

TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1

International Nuclear Information System (INIS)

Wang Yuequn; Li Yongqing; Qi Xinzhu; Yuan Wuzhou; Ai Jianping; Zhu Chuanbing; Cao Lei; Yang Hong; Liu Fang; Wu Xiushan; Liu Mingyao

2004-01-01

The tripartite motif (TRIM) proteins play important roles in a variety of cellular functions including cell proliferation, differentiation, development, oncogenesis, and apoptosis. In this study, we report the identification and characterization of the human tripartite motif-containing protein 45 (TRIM45), a novel member of the TRIM family, from a human embryonic heart cDNA library. TRIM45 has a predicted 580 amino acid open reading frame, encoding a putative 64-kDa protein. The N-terminal region harbors a RING finger, two B-boxes, and a predicted α-helical coiled-coil domain, which together form the RBCC/TRIM motif found in a large family of proteins, whereas the C-terminal region contains a filamin-type immunoglobulin (IG-FLMN) domain. Northern blot analysis indicates that TRIM45 is expressed in a variety of human adult and embryonic tissues. In the cell, TRIM45 protein is expressed both in cytoplasm and in cell nucleus. Overexpression of TRIM45 in COS-7 cells inhibits the transcriptional activities of ElK-1 and AP-1. These results suggest that TRIM45 may act as a new transcriptional repressor in mitogen-activated protein kinase signaling pathway

45 CFR 7.1 - Duty of employee to report inventions.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Duty of employee to report inventions. 7.1 Section 7.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION EMPLOYEE INVENTIONS § 7.1 Duty of employee to report inventions. Every Department employee is required to report to...

39 CFR 4.5 - Assistant Postmasters General, General Counsel, Judicial Officer, Chief Postal Inspector.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Assistant Postmasters General, General Counsel, Judicial Officer, Chief Postal Inspector. 4.5 Section 4.5 Postal Service UNITED STATES POSTAL SERVICE THE... Counsel, a Judicial Officer, a Chief Postal Inspector, and such number of officers, described in 39 U.S.C...

THE EFFECT OF ADDITION OF Nd3 + ON DIELECTRIC PROPERTIES OF Pb[Zr0.45Ti0.45(Zn1/3, Sb2/30.1]O3 SYSTEM

Directory of Open Access Journals (Sweden)

N. Abdessalem

2015-07-01

Full Text Available This work aims at, to study the influence of Nd3+ on the dielectric properties of a ceramics material of general formula: ¶Pb[Zr0.45 Ti0.45 (Zn1/3, Sb2/3 0.1]O3 and of structure perovskite. ¶The selected samples were prepared by the method of synthesis with solid way. ¶The study of the dielectric properties of the system showed that the values of the permittivity, the resistivity, increase with the addition of  Nd+3 1%.

45 CFR 74.45 - Cost and price analysis.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Cost and price analysis. 74.45 Section 74.45... ORGANIZATIONS, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Procurement Standards § 74.45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in...

Steam generator replacement in Bruce A Unit 1 and Unit 2

International Nuclear Information System (INIS)

Hart, R.S.

2007-01-01

The Bruce A Generating Station consists of four 900 MW class CANDU units. The reactor and Primary Heat Transport System for each Unit are housed within a reinforced concrete reactor vault. A large duct running below the reactor vaults accommodates the shared fuel handling system, and connects the four reactor vaults to the vacuum building. The reactor vaults, fuelling system duct and the vacuum building constitute the station vacuum containment system. Bruce A Unit 2 was shut down in 1995 and Bruce A Units 1, 3 and 4 were shutdown in 1997. Bruce A Units 3 and 4 were returned to service in late 2003 and are currently operating. Units 1 and 2 remain out of service. Bruce Power is currently undertaking a major rehabilitation of Bruce A Unit 1 and Unit 2 that will extend the in-service tile of these units by at least 25 years. Replacement of the Steam Generators (eight in each unit) is required; this work was awarded to SNC-Lavalin Nuclear (SLN). The existing steam drums (which house the steam separation and drying equipment) will be retained. Unit 2 is scheduled to be synchronized with the grid in 2009, followed by Unit 1 in 2009. Each Bruce A unit has two steam generating assemblies, one located above and to each end of the reactor. Each steam generating assembly consists of a horizontal cylindrical steam drum and four vertical Steam Generators. The vertical Steam Generators connect to individual nozzles that are located on the underside of the Steam Drum (SD). The steam drums are located in concrete shielding structures (steam drum enclosures). The lower sections of the Steam Generators penetrate the top of the reactor vaults: the containment pressure boundary is established by bellows assemblies that connect between the reactor vault roof slab and the Steam Generators. Each Steam Generators is supported from he bottom by a trapeze that is suspended from the reactor vault top structure. The Steam Generator Replacement (SGR) methodology developed by SLN for Unit 1

40 CFR 1.45 - Office of Research and Development.

Science.gov (United States)

2010-07-01

... ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.45 Office of Research and Development. The Office of... of integrated pest management strategies for the management of agriculture and urban pests which..., such as predictive models to determine similarities and differences among test organisms and man...

6-Butyl-5-(4-methoxyphenoxy-3-phenyl-3H-1,2,3-triazolo[4,5-d]pyrimidin-7(6H-one

Directory of Open Access Journals (Sweden)

Hong-Mei Wang

2009-12-01

Full Text Available The asymmetric unit of the title compound, C21H21N5O3, consists of two geometrically similar molecules. The fused rings of the triazolo[4,5-d]pyrimidine system are nearly coplanar, making dihedral angels of 1.48 (18 and 1.34 (16°, and the phenyl rings are twisted by 12.3 (1 and 8.7 (1° with respect to the triazolopyrimidine plane. The ethyl groups of the n-butyl side chains are disordered over two sites in each of the independent molecules, the ratios of occupancies being 0.60:0.40 and 0.61:0.39.

40 CFR 60.45Da - Standard for mercury (Hg).

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for mercury (Hg). 60.45Da... for mercury (Hg). (a) For each coal-fired electric utility steam generating unit other than an IGCC... gases that contain mercury (Hg) emissions in excess of each Hg emissions limit in paragraphs (a)(1...

45 CFR 310.1 - What definitions apply to this part?

Science.gov (United States)

2010-10-01

... SERVICES COMPUTERIZED TRIBAL IV-D SYSTEMS AND OFFICE AUTOMATION General Provisions § 310.1 What definitions... 45 Public Welfare 2 2010-10-01 2010-10-01 false What definitions apply to this part? 310.1 Section...) Office Automation means a generic adjunct component of a computer system that supports the routine...

Functional Analysis of Kori Unit 1

International Nuclear Information System (INIS)

Choi, Seong Soo; Han, Jeong Hyun; Heo, Tae Young

2009-07-01

Function Analysis of Kori Unit 1 has been performed as a part of independent human factors review tasks for control room renovation of the plant. The top level goal defined for the scope of function analysis is 'Generate Electricity'. Through this function analysis of Kori Unit 1, the detailed sub-functions extracted from the existing design documents and procedures, functional relationships among the high level functions, functional classification of each hierarchical level, and tree diagrams of the hierarchical function structures of the plant were developed and identified as the result of the project. In addition, we investigated and compiled the specifications of MMIS devices used in Ulchin Nuclear Power Plant Unit 5,6 in accordance with the request from KAERI. The results of those researches will be used as basis data for independent review of the control room MMIS design of the Kori Unit 1

Specification of Eight 2400 W @ 1.8 K Refrigeration Units for the LHC

CERN Document Server

Claudet, S; Jäger, B; Millet, F; Roussel, P; Tavian, L; Wagner, U

2000-01-01

The cooling capacity below 2 K for the superconducting magnets in the Large Hadron Collider (LHC), at CERN, will be provided by eight refrigeration units at 1.8 K, each of them coupled to a 4.5 K refrigerator. Taking into account the cryogenic architecture of the LHC and corresponding process design constraints, a reference solution based on a combination of cold centrifugal and warm volumetric compressors was established in 1997. The process and technical requirements expressed in the specification issued in 1998 and the procurement scenario based on pre-series acceptance prior to final series delivery between 2002 and 2004 are presented in this paper.

45 CFR 61.1 - The Healthcare Integrity and Protection Data Bank.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false The Healthcare Integrity and Protection Data Bank. 61.1 Section 61.1 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION HEALTHCARE INTEGRITY AND PROTECTION DATA BANK FOR FINAL ADVERSE INFORMATION ON HEALTH CARE PROVIDERS...

27 CFR 45.46 - Tax-exempt label.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Tax-exempt label. 45.46..., WITHOUT PAYMENT OF TAX, FOR USE OF THE UNITED STATES Packaging Requirements § 45.46 Tax-exempt label... Be Sold.” adequately imprinted on the package or on a label securely affixed thereto. (72 Stat. 1422...

Multi-Unit Initiating Event Analysis for a Single-Unit Internal Events Level 1 PSA

Energy Technology Data Exchange (ETDEWEB)

Kim, Dong San; Park, Jin Hee; Lim, Ho Gon [KAERI, Daejeon (Korea, Republic of)

2016-05-15

The Fukushima nuclear accident in 2011 highlighted the importance of considering the risks from multi-unit accidents at a site. The ASME/ANS probabilistic risk assessment (PRA) standard also includes some requirements related to multi-unit aspects, one of which (IE-B5) is as follows: 'For multi-unit sites with shared systems, DO NOT SUBSUME multi-unit initiating events if they impact mitigation capability [1].' However, the existing single-unit PSA models do not explicitly consider multi-unit initiating events and hence systems shared by multiple units (e.g., alternate AC diesel generator) are fully credited for the single unit and ignores the need for the shared systems by other units at the same site [2]. This paper describes the results of the multi-unit initiating event (IE) analysis performed as a part of the at-power internal events Level 1 probabilistic safety assessment (PSA) for an OPR1000 single unit ('reference unit'). In this study, a multi-unit initiating event analysis for a single-unit PSA was performed, and using the results, dual-unit LOOP initiating event was added to the existing PSA model for the reference unit (OPR1000 type). Event trees were developed for dual-unit LOOP and dual-unit SBO which can be transferred from dual- unit LOOP. Moreover, CCF basic events for 5 diesel generators were modelled. In case of simultaneous SBO occurrences in both units, this study compared two different assumptions on the availability of the AAC D/G. As a result, when dual-unit LOOP initiating event was added to the existing single-unit PSA model, the total CDF increased by 1∼ 2% depending on the probability that the AAC D/G is available to a specific unit in case of simultaneous SBO in both units.

45 CFR 3.1 - Definitions.

Science.gov (United States)

2010-10-01

... area, containing about 318 acres, acquired by the United States in several parcels in the years 1935... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL... Montgomery County, Maryland, over which the United States acquired exclusive jurisdiction under the Act of...

L’EFFET DE L’ADDITION DE Nd3+ SUR LES PROPRIETES DIELECTRIQUES DU SYSTEME Pb[Zr0.45Ti0.45(Zn1/3, Sb2/30.1]O3

Directory of Open Access Journals (Sweden)

N. Abdessalem

2011-12-01

Full Text Available This work aims at, to study the influence of Nd3+ on the dielectric properties of a ceramics material of general formula: Pb[Zr0.45 Ti0.45 (Zn1/3, Sb2/3 0.1]O3 and of structure perovskite. The selected samples were prepared by the method of synthesis with solid way. The study of the dielectric properties of the system showed that the values of the permittivity, the resistivity, increase with the addition of Nd+3 1%. Key words: Ceramics PZT, Dielectric Properties, Polarization.

A chimeric 18L1-45RG1 virus-like particle vaccine cross-protects against oncogenic alpha-7 human papillomavirus types.

Directory of Open Access Journals (Sweden)

Bettina Huber

Full Text Available Persistent infection with oncogenic human papillomaviruses (HPV types causes all cervical and a subset of other anogenital and oropharyngeal carcinomas. Four high-risk (hr mucosal types HPV16, 18, 45, or 59 cause almost all cervical adenocarcinomas (AC, a subset of cervical cancer (CxC. Although the incidence of cervical squamous cell carcinoma (SCC has dramatically decreased following introduction of Papanicolaou (PAP screening, the proportion of AC has relatively increased. Cervical SCC arise mainly from the ectocervix, whereas AC originate primarily from the endocervical canal, which is less accessible to obtain viable PAP smears. Licensed (bivalent and quadrivalent HPV vaccines comprise virus-like particles (VLP of the most important hr HPV16 and 18, self-assembled from the major capsid protein L1. Due to mainly type-restricted efficacy, both vaccines do not target 13 additional hr mucosal types causing 30% of CxC. The papillomavirus genus alpha species 7 (α7 includes a group of hr types of which HPV18, 45, 59 are proportionally overrepresented in cervical AC and only partially (HPV18 targeted by current vaccines. To target these types, we generated a chimeric vaccine antigen that consists of a cross-neutralizing epitope (homologue of HPV16 RG1 of the L2 minor capsid protein of HPV45 genetically inserted into a surface loop of HPV18 L1 VLP (18L1-45RG1. Vaccination of NZW rabbits with 18L1-45RG1 VLP plus alum-MPL adjuvant induced high-titer neutralizing antibodies against homologous HPV18, that cross-neutralized non-cognate hr α7 types HPV39, 45, 68, but not HPV59, and low risk HPV70 in vitro, and induced a robust L1-specific cellular immune response. Passive immunization protected mice against experimental vaginal challenge with pseudovirions of HPV18, 39, 45 and 68, but not HPV59 or the distantly related α9 type HPV16. 18L1-45RG1 VLP might be combined with our previously described 16L1-16RG1 VLP to develop a second generation bivalent

45 CFR 660.1 - What is the purpose of these regulations?

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false What is the purpose of these regulations? 660.1 Section 660.1 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION INTERGOVERNMENTAL REVIEW OF THE NATIONAL SCIENCE FOUNDATION PROGRAMS AND ACTIVITIES § 660.1 What...

39 CFR 221.1 - The United States Postal Service.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false The United States Postal Service. 221.1 Section 221.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION GENERAL ORGANIZATION § 221.1 The United States Postal Service. The United States Postal Service was established as an...

N-(4,5-Diazafluoren-9-ylideneaniline

Directory of Open Access Journals (Sweden)

Hui Cang

2008-07-01

Full Text Available In the molecule of the title compound, C17H11N3, the 4,5-diazafluorenylidene unit is nearly planar and is oriented with respect to the phenyl ring at a dihedral angle of 75.75 (3°. In the crystal structure, the molecules are aligned in the [100] direction in such a way that neighbouring 4,5-diazafluorenylidene planes face each other in an antiparallel fashion.

Fragrance material review on 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one.

Science.gov (United States)

Scognamiglio, J; Letizia, C S; Api, A M

2013-12-01

A toxicologic and dermatologic review of 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one when used as a fragrance ingredient is presented. 1-Spiro[4.5]dec-7-en-7-yl-4-pent-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all published and unpublished toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one were evaluated then summarized and includes acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, phototoxicity, photoallergy, repeated dose, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances. Copyright © 2013 Elsevier Ltd. All rights reserved.

Heterogeneity of Metastatic Melanoma:  Correlation of MITF With Its Transcriptional Targets MLSN1, PEDF, HMB-45, and MART-1.

Science.gov (United States)

Zand, Sarvenaz; Buzney, Elizabeth; Duncan, Lyn M; Dadras, Soheil S

2016-09-01

Histologic and molecular heterogeneity is well recognized in malignant melanoma; however, the diversity of expression of new and classic melanoma markers has not been correlated in serial sections of metastases. We examined and correlated the expression of microphthalmia transcription factor (MITF) with its transcriptional targets, including melastatin (MLSN1/TRPM1), pigment epithelium-derived factor (SERPINF1/PEDF), SILV/PMEL17/GP100 (human melanoma black 45 [HMB-45]), and melanoma antigen recognized by T cells 1 (MART-1)/MLANA, in 13 melanoma metastases in lymph nodes of 13 patients. The expression levels and patterns of marker expression were recorded by a semiquantitative, 4-point ordinal reactivity method. Our results showed a consistently robust and diffuse expression of MITF protein in 12 (92%) of 13 metastatic tumors compared with variable expression of MLSN1 (46%) messenger RNA or PEDF (75%), HMB-45 (54%), and MART-1 (46%) proteins. Overall, in melanoma lymph node metastases, MITF protein expression was not tightly correlated with its gene targets. Moreover, the immunoreactivity for MITF, compared with MART-1 and HMB-45, was retained, supporting immunohistochemical detection of MITF as a more sensitive method of detecting metastatic melanoma. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Aryl-1H-imidazole[4,5f][1,10]phenanthroline Cu(II) complexes: Electrochemical and DNA interaction studies.

Science.gov (United States)

Rajebhosale, Bharati S; Dongre, Shivali N; Deshpande, Sameer S; Kate, Anup N; Kumbhar, Anupa A

2017-10-01

The reaction of aryl imidazo[4,5f] [1,10]phenanthrolines with Cu(NO 3 ) 2 lead to the formation of Cu(II) complexes of the type [Cu(L)(NO 3 ) 2 ] where L=PIP, 2-(phenyl) [4,5f] imidazo phenanthroline; HPIP=2-(2-hydroxyphenyl)imidazo [4,5f] phenanthroline and NIP=2-(naphthyl) [4,5f] imidazo phenanthroline. The interaction of these complexes with calf thymus DNA has been studied using viscosity measurements, UV-visible and fluorescence spectroscopy. Chemical nuclease activity of these complexes has also been investigated. All complexes cleave DNA via oxidative pathway involving singlet oxygen. Molecular docking studies revealed that these complexes bind to DNA through minor groove. Copyright © 2017 Elsevier Inc. All rights reserved.

1-[3-(2-Methyl-4-phenylquinolin-3-yl-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-propane-1-one

Directory of Open Access Journals (Sweden)

Allaoua Kedjadja

2015-06-01

Full Text Available A novel compound, 1-[3-(2-methyl-4-phenylquinolin-3-yl-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-propane-1-one (3 has been synthesized by cyclocondensation of (E-1-(2-methyl-4-phenylquinolin-3-yl-3-phenylprop-2-en-1-one (2 and hydrazine hydrate in propionic acid. The structure of this compound was established by elemental analysis, IR, 1H-NMR, 13C-NMR and MS data.

26 CFR 1.45G-0 - Table of contents for the railroad track maintenance credit rules.

Science.gov (United States)

2010-04-01

.... (1) In general. (2) Definitions. (i) Trade or business. (ii) Group and controlled group. (iii) Group.... (6) Tax accounting periods used. (i) In general. (ii) Special rule when timing of QRTME is... table of contents for § 1.45G-1. § 1.45G-1Railroad track maintenance credit. (a) In general. (b...

Pickering Unit 1 chemical cleaning

International Nuclear Information System (INIS)

Smee, J.L.; Fiola, R.J.; Brennenstuhl, K.R.; Zerkee, D.D.; Daniel, C.M.

1995-01-01

The secondary sides of all 12 boilers at Pickering Unit 1 were chemically cleaned in 1994 by the team of Ontario Hydro, B and W International (Cambridge, Ontario) and B and W Nuclear Technologies (Lynchburg, Virginia). A multi-step EPRI/SGOG process was employed in a similar manner to previous clearings at Units 5 and 6 in 1992 and 1993, respectively. A major innovation with the Unit 1 cleaning was the incorporation of a crevice cleaning step, the first time this had been done on Ontario Hydro plants. In addition, six boilers were cleaned in parallel compared to three at a time in previous Pickering cleanings. This significantly reduced cleaning time. A total of 6,770 kg of sludge was removed through direct chemical dissolution. It consisted of 66% iron/nickel oxides and 28% copper metal. A total of 1,600,000 L (420,000 US gallons) of liquid waste was produced. It was processed through the spent solvent treatment facility located at the Bruce Nuclear Power Development site. Visual inspection performed after the cleaning indicated that the crevices between the boiler tubes and the tube support structure were completely clear of deposit and the general condition of the tubing and lattice bars appeared to be in 'as new' condition. (author)

Purification, crystallization and preliminary X-ray diffraction analysis of human Gadd45γ

International Nuclear Information System (INIS)

Zhang, Wenzheng; Zhao, Mingzhuo; Li, Jianhui; Li, Xuemei; Zeng, ZongHao; Rao, Zihe

2008-01-01

The human Gadd45γ protein has been crystallized as a prelude towards determination of its three-dimensional structure by X-ray crystallography. Gadd45, MyD118 and CR6 (also termed Gadd45α, Gadd45β and Gadd45γ, respectively) comprise a family of proteins that play important roles in negative growth control, maintenance of genomic stability, DNA repair, cell-cycle control and apoptosis. Recombinant human Gadd45γ and its selenomethionine derivative were expressed in an Escherichia coli expression system and purified; they were then crystallized using the hanging-drop vapour-diffusion method. Diffraction-quality crystals were grown at 291 K using PEG 3350 as precipitant. Using synchrotron radiation, the best diffraction data were collected to 2.3 Å resolution for native crystals at 100 K; selenomethionyl derivative data were collected to 3.3 Å resolution. All the crystals belonged to space group I2 1 3, with approximate unit-cell parameters a = b = c = 126 Å

Crystal and molecular structures of benzo[4,5]imidazo[1,2-c]quinazolin-6-one and 10-carboxybenzo[4,5]imidazo[1,2-c]quinazolin-6-one: A quantum-chemical study of their tautomerism

International Nuclear Information System (INIS)

Koval’chukova, O. V.; Stash, A. I.; Strashnov, P. V.; Neborak, E. V.; Strashnova, S. B.; Zaitsev, B. E.

2011-01-01

Benzo[4,5]imidazo[1,2-c]quinazolin-6-one and 10-carboxybenzo[4,5]imidazo[1,2-c]quinazolin-6-one were isolated in the crystalline state and studied by X-ray diffraction. The crystal and molecular structures of these compounds were determined by X-ray diffraction. The energy characteristics of the tautomeric and ionic forms were calculated by the quantum-chemical PM3 method.

49 CFR 1242.45 - Passenger and other revenue equipment (account XX-27-45).

Science.gov (United States)

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Passenger and other revenue equipment (account XX-27-45). 1242.45 Section 1242.45 Transportation Other Regulations Relating to Transportation... RAILROADS 1 Operating Expenses-Equipment § 1242.45 Passenger and other revenue equipment (account XX-27-45...

5-Isopropylidene-1,3-dithiolo[4,5-d][1,3]dithiole-2-thione

Directory of Open Access Journals (Sweden)

Yoshiro Yamashita

2009-05-01

Full Text Available The title compound, C7H6S5, contains a 5-ylidene-1,3-dithiolo[4,5-d][1,3]dithiole-2-thione framework, which is an important synthetic precursor of multi-dimensional organic superconductors and conductors. The molecular framework is planar with an r.m.s. deviation of 0.012 Å for the non-H atoms. In the crystal structure, molecules are linked by short intermolecular S...S interactions [3.501 (5 and 3.581 (4 Å], constructing a zigzag molecular tape network along the c axis.

45 CFR 630.665 - State.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false State. 630.665 Section 630.665 Public Welfare... DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 630.665 State. State means any of the States of the United States, the District of Columbia, the Commonwealth of Puerto Rico, or any territory or...

Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues.

Science.gov (United States)

Cunico, Wilson; Cechinel, Cleber A; Bonacorso, Helio G; Martins, Marcos A P; Zanatta, Nilo; de Souza, Marcus V N; Freitas, Isabela O; Soares, Rodrigo P P; Krettli, Antoniana U

2006-02-01

The antimalarial activity of chloroquine-pyrazole analogues, synthesized from the reaction of 1,1,1-trifluoro-4-methoxy-3-alken-2-ones with 4-hydrazino-7-chloroquinoline, has been evaluated in vitro against a chloroquine resistant Plasmodium falciparum clone. Parasite growth in the presence of the test drugs was measured by incorporation of [(3)H]hypoxanthine in comparison to controls with no drugs. All but one of the eight (4,5-dihydropyrazol-1-yl) chloroquine 2 derivatives tested showed a significant activity in vitro, thus, are a promising new class of antimalarials. The three most active ones were also tested in vivo against Plasmodium berghei in mice. However, the (pyrazol-1-yl) chloroquine 3 derivatives were mostly inactive, suggesting that the aromatic functionality of the pyrazole ring was critical.

Phase 1 remedial investigation report for 200-BP-1 operable unit. Volume 1

Energy Technology Data Exchange (ETDEWEB)

1993-09-01

The US Department of Energy (DOE) Hanford Site, in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989 included the 200 Areas of the Hanford Site on the National Priority List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA). Inclusion on the NPL initiated the remedial investigation (RD process for the 200-BP-1 operable unit. These efforts are being addressed through the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989) which was negotiated and approved by the DOE, the EPA, and the State of Washington Department of Ecology (Ecology) in May 1989. This agreement, known as the Tri-Party Agreement, governs all CERCLA efforts at Hanford. In March of 1990, the Department of Energy, Richland Operations (DOE-RL) issued a Remedial Investigation/Feasibility Study (RI/FS) work plan (DOE-RL 1990a) for the 200-BP-1 operable unit. The work plan initiated the first phase of site characterization activities associated with the 200-BP-1 operable unit. The purpose of the 200-BP-1 operable unit RI is to gather and develop the necessary information to adequately understand the risks to human health and the environment posed by the site and to support the development and analysis of remedial alternatives during the FS. The RI analysis will, in turn, be used by Tri-Party Agreement signatories to make a risk-management-based selection of remedies for the releases of hazardous substances that have occurred from the 200-BP-1 operable unit.

45 CFR 1351.1 - Significant terms.

Science.gov (United States)

2010-10-01

... homeless youth service providers in skill areas that will directly strengthen service delivery. (m) A State includes any State of the United States, the District of Columbia, the Commonwealth of Puerto Rico, the Trust Territory of the Pacific Islands, and any territory or possession of the United States. (n...

Erie Nuclear Plant, Units 1 and 2. License application, preliminary safety analysis report, volume 1: chapter 1

International Nuclear Information System (INIS)

1977-01-01

Erie 1 and 2 reactors will be located on a site consisting of 1,740 acres in Berlin Township about 2.4 miles south of Lake Erie and 8.9 miles southeast of Sandusky, Ohio. Lake Erie will provide makeup water. The ultimate heat sink will be a 40 acre cooling reservoir shared by both units. Each unit has a proposed core thermal power level of 3,760 MW(t) and a nominal net capacity of about 1282 MW(e). Unit 1 is scheduled for commercial operation by 4/1/84 and Unit 2 by 4/1/86. Fuel will be Zircaloy-4 clad tubes containing cylindrical fuel pellets of UO 2 . B and W pressurized water reactor units to be employed are described in DOCKET-STN-50561

37 CFR 1.413 - The United States International Searching Authority.

Science.gov (United States)

2010-07-01

... Processing Provisions General Information § 1.413 The United States International Searching Authority. (a... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false The United States International Searching Authority. 1.413 Section 1.413 Patents, Trademarks, and Copyrights UNITED STATES PATENT...

4,5-Di-O-Caffeoylquinic Acid from Ligularia fischeri Suppresses Inflammatory Responses Through TRPV1 Activation.

Science.gov (United States)

Kim, Yiseul; Kim, Jung Tae; Park, Joonwoo; Son, Hee Jin; Kim, Eun-Young; Lee, Young Joo; Rhyu, Mee-Ra

2017-10-01

Ligularia fischeri (Ledeb.) Turcz., a perennial plant native to northeastern Asia, has long been used as folk remedies for the alleviation of inflammatory symptoms. We investigated whether the extract of L. fischeri (LFEx) and caffeoylquinic acid (CQA) derivatives, the pharmacologically active ingredients identified from L. fischeri, regulate inflammation via a transient receptor potential vanilloid 1 (TRPV1)-mediated pathway. Changes in intracellular Ca 2+ levels to the LFEx and trans-5-O-CQA, 3,4-di-O-CQA, 3,5-di-O-CQA, and 4,5-di-O-CQA were monitored in TRPV1-expressing human embryonic kidney cell HEK 293T. LFEx and 4,5-di-O-CQA (EC 50  = 69.34 ± 1.12 μM) activated TRPV1, and these activations were significantly inhibited by ruthenium red, a general blocker of TRP channels, and capsazepine, a specific antagonist of TRPV1. 4,5-Di-O-CQA has been determined having antiinflammatory effect under hypoxic conditions by detecting the expression of cyclooxygenase-2 (COX-2), a representative inflammatory marker, and cellular migration in human pulmonary epithelial A549 cells. 4,5-Di-O-CQA suppressed COX-2 expression and cell migration, and this inhibition was countered by co-treatment with capsazepine. This study provides evidence that L. fischeri is selective to inflammatory responses via a TRPV1-mediated pathway, and 4,5-di-O-CQA might play a key role to create these effects. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Relative power density distribution calculations of the Kori unit 1 pressurized water reactor with full-scope explicit modeling of monte carlo simulation

International Nuclear Information System (INIS)

Kim, J. O.; Kim, J. K.

1997-01-01

Relative power density distributions of the Kori unit 1 pressurized water reactor calculated by Monte Carlo modeling with the MCNP code. The Kori unit 1 core is modeled on a three-dimensional representation of the one-eighth of the reactor in-vessel component with reflective boundaries at 0 and 45 degrees. The axial core model is based on half core symmetry and is divided into four axial segments. Fission reaction density in each rod is calculated by following 100 cycles with 5,000 test neutrons in each cycle after starting with a localized neutron source and ten noncontributing settle cycles. Relative assembly power distributions are calculated from fission reaction densities of rods in assembly. After 100 cycle calculations, the system coverages to a κ value of 1.00039 ≥ 0.00084. Relative assembly power distribution is nearly the same with that of the Kori unit 1 FSAR. Applicability of the full-scope Monte Carlo simulation in the power distribution calculation is examined by the relative root mean square error of 2.159%. (author)

Phase 1 remedial investigation report for 200-BP-1 operable unit

International Nuclear Information System (INIS)

1993-09-01

The US Department of Energy (DOE) Hanford Site, in Washington State is organized into numerically designated operational areas including the 100, 200, 300, 400, 600, and 1100 Areas. The US Environmental Protection Agency (EPA), in November 1989 included the 200 Areas of the Hanford Site on the National Priority List (NPL) under the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (CERCLA). Inclusion on the NPL initiated the remedial investigation (RD process for the 200-BP-1 operable unit. These efforts are being addressed through the Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989) which was negotiated and approved by the DOE, the EPA, and the State of Washington Department of Ecology (Ecology) in May 1989. This agreement, known as the Tri-Party Agreement, governs all CERCLA efforts at Hanford. In March of 1990, the Department of Energy, Richland Operations (DOE-RL) issued a Remedial Investigation/Feasibility Study (RI/FS) work plan (DOE-RL 1990a) for the 200-BP-1 operable unit. The work plan initiated the first phase of site characterization activities associated with the 200-BP-1 operable unit. The purpose of the 200-BP-1 operable unit RI is to gather and develop the necessary information to adequately understand the risks to human health and the environment posed by the site and to support the development and analysis of remedial alternatives during the FS. The RI analysis will, in turn, be used by Tri-Party Agreement signatories to make a risk-management-based selection of remedies for the releases of hazardous substances that have occurred from the 200-BP-1 operable unit

Polyamines as mediators of insulin's action on pyruvate dehydrogenase, 45Ca2+ fluxes, and membrane transport

International Nuclear Information System (INIS)

Goldstone, A.D.; Koenig, H.; Lu, C.Y.

1986-01-01

Insulin (IN) induces a rapid stimulation of Ca 2+ fluxes and membrane transport in mouse kidney cortex which involves rapid polyamine synthesis. 1.3 nM (IN) induced an early ( 45 Ca 2+ influx and efflux peaked at 1-2 min and returned to basal levels by 5-10 min. The ODC inhibitor α-difluoromethylornithine (DFMO, 5 mM) abolished IN stimulation of PDH, 45 Ca 2+ fluxes and membrane transport, and putrescine (.5 mM) nullified DFMO inhibition. IN (50 mUnits/kg) in rats induced an early ( 2+ fluxes, and membrane transport

75 FR 46833 - 45th Anniversary of Medicare and Medicaid

Science.gov (United States)

2010-08-03

... Part III The President Proclamation 8544--45th Anniversary of Medicare and Medicaid #0; #0; #0..., 2010 45th Anniversary of Medicare and Medicaid By the President of the United States of America A Proclamation When President Lyndon B. Johnson signed Medicare and Medicaid into law on July 30, 1965, millions...

Conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3, Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, Surry Unit Nos. 1 and 2 (Docket Nos. 50-334, 50-338, 50-339, 50-280, and 50-281)

International Nuclear Information System (INIS)

Haroldsen, R.

1985-09-01

This report provides a review of the submittals for Beaver Valley, Unit No. 1, North Anna, Unit Nos. 1 and 2, and Surry, Unit Nos. 1 and 2, for conformance to Generic Letter 83-28, Items 3.1.3 and 3.2.3. The specific plants selected were reviewed as a group because of similarity in type and applicability of review items

46 CFR 167.45-1 - Steam, carbon dioxide, and halon fire extinguishing systems.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Steam, carbon dioxide, and halon fire extinguishing....45-1 Steam, carbon dioxide, and halon fire extinguishing systems. (a) General requirements. (1...-extinguishing system. On such vessels contracted for prior to January 1, 1962, a steam smothering system may be...

Summary of Notifiable Diseases, United States. Volume 45, Number 53.

Science.gov (United States)

1997-10-31

Trichinosis Tuberculosis Typhoid fever Yellow fever NOTE: Although varicella is not a nationally notifiable disease, the Council of State and...plague among humans, two of which were fatal, were re- ported in the United States (two cases in Arizona, one in Colorado, and two in New Mexico ). Both...13 cases per year) were reported in the United States. Of these cases, 80% occurred in the southwestern states of New Mexico , Arizona, and

Generation of 4,5-Dihydro-1,2,3-oxadiazole and Study of the Decomposition Products

OpenAIRE

Singh, Neeraj

2015-01-01

4,5-Dihydro-1,2,3-oxadiazoles are postulated to be key intermediates in the synthesis of ketones from alkenes on an industrial scale, alkylation of DNA in vivo, decomposition of N-nitrosoureas (potent carcinogens), and are also a subject of great interest for theoretical chemists. In this thesis, formation of the parent compound and decay into secondary products has been studied by NMR monitoring analysis. The elusive properties and the intermediacy of the parent compound, 4,5-dihydro-1,2,3-o...

26 CFR 1.851-7 - Certain unit investment trusts.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Certain unit investment trusts. 1.851-7 Section... unit investment trusts. (a) In general. For purposes of the Internal Revenue Code, a unit investment.... Accordingly, a unit investment trust is not a taxpayer subject to taxation under the Internal Revenue Code. No...

1-[3-(4-Chlorophenyl-5-(4-methoxyphenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Directory of Open Access Journals (Sweden)

Hoong-Kun Fun

2012-04-01

Full Text Available In the title compound, C18H17ClN2O2, the benzene rings form dihedral angles of 6.69 (6 and 74.88 (5° with the 4,5-dihydro-1H-pyrazole ring. The benzene rings form a dihedral angle of 76.67 (5° with each other. In the crystal, molecules are linked via bifurcated (C,C–H...O hydrogen bonds into chains along [010]. The crystal structure is further consolidated by C—H...π interactions.

26 CFR 1.993-7 - Definition of United States.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Definition of United States. 1.993-7 Section 1.993-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Domestic International Sales Corporations § 1.993-7 Definition of United States...

Corrective Action Decision Document for Corrective Action Unit 516: Septic Systems and Discharge Points, Nevada Test Site, Nevada, Rev. No.: 1 with ROTC 1

Energy Technology Data Exchange (ETDEWEB)

Alfred N. Wickline

2004-04-01

This Corrective Action Decision Document (CADD) has been prepared for Corrective Action Unit (CAU) 516, Septic Systems and Discharge Points, Nevada Test Site, Nevada, in accordance with the ''Federal Facility Agreement and Consent Order'' (1996). Corrective Action Unit 516 is comprised of the following Corrective Action Sites (CASs): (1) 03-59-01 - Bldg 3C-36 Septic System; (2) 03-59-02 - Bldg 3C-45 Septic System; (3) 06-51-01 - Sump and Piping; (4) 06-51-02 - Clay Pipe and Debris; (5) 06-51-03 - Clean Out Box and Piping; and (7) 22-19-04 - Vehicle Decontamination Area. The purpose of this CADD is to identify and provide the rationale for the recommendation of an acceptable corrective action alternative for each CAS within CAU 516. Corrective action investigation activities were performed between July 22 and August 14, 2003, as set forth in the Corrective Action Investigation Plan. Supplemental sampling was conducted in late 2003 and early 2004.

45 CFR 1203.4 - Discrimination prohibited.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Discrimination prohibited. 1203.4 Section 1203.4... OF 1964 § 1203.4 Discrimination prohibited. (a) General. A person in the United States shall not, on... benefits of, or be otherwise subjected to discrimination under, a program to which this part applies. (b...

Attributes for NHDPlus Catchments (Version 1.1) for the Conterminous United States: Physiographic Provinces

Science.gov (United States)

Wieczorek, Michael; LaMotte, Andrew E.

2010-01-01

This dataset represents the area of each physiographic province (Fenneman and Johnson, 1946) in square meters, compiled for every catchment of NHDPlus for the conterminous United States. The source data are from Fenneman and Johnson's Physiographic Provinces of the United States, which is based on 8 major divisions, 25 provinces, and 86 sections representing distinctive areas having common topography, rock type and structure, and geologic and geomorphic history (Fenneman and Johnson, 1946). The NHDPlus Version 1.1 is an integrated suite of application-ready geospatial datasets that incorporates many of the best features of the National Hydrography Dataset (NHD) and the National Elevation Dataset (NED). The NHDPlus includes a stream network (based on the 1:100,00-scale NHD), improved networking, naming, and value-added attributes (VAAs). NHDPlus also includes elevation-derived catchments (drainage areas) produced using a drainage enforcement technique first widely used in New England, and thus referred to as "the New England Method." This technique involves "burning in" the 1:100,000-scale NHD and when available building "walls" using the National Watershed Boundary Dataset (WBD). The resulting modified digital elevation model (HydroDEM) is used to produce hydrologic derivatives that agree with the NHD and WBD. Over the past two years, an interdisciplinary team from the U.S. Geological Survey (USGS), and the U.S. Environmental Protection Agency (USEPA), and contractors, found that this method produces the best quality NHD catchments using an automated process (USEPA, 2007). The NHDPlus dataset is organized by 18 Production Units that cover the conterminous United States. The NHDPlus version 1.1 data are grouped by the U.S. Geologic Survey's Major River Basins (MRBs, Crawford and others, 2006). MRB1, covering the New England and Mid-Atlantic River basins, contains NHDPlus Production Units 1 and 2. MRB2, covering the South Atlantic-Gulf and Tennessee River basins

Spent fuel pool cooling system upgrade for Kori Unit 1

International Nuclear Information System (INIS)

Sun Park, Jong; In Shin, Kyung

2014-01-01

Following Fukushima nuclear power plant accident, the needs for reliable performance of its own safety functions of Spent Fuel Pool Cooling System (SFPCS) has risen significantly to maintain the plant in a safe condition. Regulatory Guide 1.13 of United States Nuclear Regulatory Commission (USNRC) requires the SFPCS shall be designed safety related as Quality Group C and Seismic Category 1. However, the existing Spent Fuel Pool (SFP) of KORI Unit 1 was not designed as a safety system. In order to comply with the above licensing requirement for the extended operational life of KORI Unit 1, it has been decided to add a safety related Seismic Category 1 Makeup System to KORI Unit 1 and the existing SFPCS to be modified in dedicated channels with safety related equipment to enhance system's reliability as a means of providing diversity. This paper focuses on describing the relevant design requirements, applications, and supplemental facilities to the SFPCS of KORI Unit 1. (authors)

Audiotape Feedback for Essays in Distance Education

NARCIS (Netherlands)

Kirschner, P.A.; Brink, H. van den; Meester, M.

1991-01-01

Students who were required to write three short essays for a university level course on photochemistry at the Open university of the Netherlands received either audio-cassette or written feedback on their essays. The students receiving the audio feedback described their experience as personal,

Overview of the Use of Media in Distance Education. I.E.T. Paper on Broadcasting No. 220.

Science.gov (United States)

Bates, A. W.

This paper reviews the use of different audio-visual media in distance education, including terrestrial broadcasting, cable satellite, videocassettes, audiocassettes, telephone teaching, viewdata, teletext, microcomputers, and interactive video. Trends in distance education are also summarized and related to trends in media technology development.…

A Communication Process: Electronic Media in Distance Education--A Review.

Science.gov (United States)

George, Donald; And Others

1989-01-01

Reviews the current use of electronic media in distance education, emphasizing Canadian examples. Examines broadcast television, videotape, satellite, telephone, radio, audiocassette, and computer. Discusses trends in media use and institutional development, focusing on education as communication and on the importance of combining different media.…

45 CFR 1170.45 - Housing.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Housing. 1170.45 Section 1170.45 Public Welfare... ACTIVITIES Postsecondary Education § 1170.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall provide comparable, convenient, and accessible...

37 CFR 1.412 - The United States Receiving Office.

Science.gov (United States)

2010-07-01

... Information § 1.412 The United States Receiving Office. (a) The United States Patent and Trademark Office is a Receiving Office only for applicants who are residents or nationals of the United States of America. (b) The... “United States Receiving Office” or by the abbreviation “RO/US.” (c) The major functions of the Receiving...

45 CFR 605.45 - Housing.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Housing. 605.45 Section 605.45 Public Welfare... § 605.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall provide comparable, convenient, and accessible housing to handicapped students at...

NZG 201 portable spectrometric unit

International Nuclear Information System (INIS)

Jursa, P.; Novakova, O.; Slezak, V.

The NZG 201 spectrometric unit is a portable single-channel processing unit supplied from the mains or a battery which allows the qualitative and quantitative measurement of different types of ionizing radiation when connected to a suitable detection unit. The circuit layout and the choice of control elements makes the spectrometric unit suitable for use with scintillation detector units. The spectrometric unit consists of a pulse amplifier, an amplitude pulse analyzer, a pulse counter, a pulse rate counter with an output for a recorder, a high voltage source and a low voltage source. The block diagram is given. All circuits are modular and are mounted on PCB's. The apparatus is built in a steel cabinet with a raised edge which protects the control elements. The linear pulse amplifier has a maximum gain of 1024, the pulse counter has a maximum capacity of 10 6 -1 imp and time resolution better than 0.5 μs. The temperature interval at which the apparatus is operational is 0 to 45 degC, its weight is 12.5 kg and dimensions 36x280x310 mm, energy range O.025 to 2.5 MeV, for 137 Cs the energy resolution is 8 to 10%. The spectrometric unit NZG 2O1 may, with regard to its parameters, number and range of control elements, be used as a universal measuring unit. (J.P.)

Effects of a mass media behavioral treatment for chronic headache : A pilot study

NARCIS (Netherlands)

deBruijnKofman, AT; vandeWiel, H; Groenman, NH; Sorbi, MJ; Klip, E

1997-01-01

This article presents the results of a pilot study evaluating the efficacy of a mess media self-help behavioral treatment program for chronic headache. The program consisted of a self-help textbook, an exercise book, 10 television programs, 11 radio programs, and 3 audiocassettes with relaxation

Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides

Directory of Open Access Journals (Sweden)

Eman M. Flefel

2017-01-01

Full Text Available New 1-thia-azaspiro[4.5]decane derivatives, their derived thiazolopyrimidine and 1,3,4-thiadiazole compounds were synthesized. The thioglycoside derivatives of the synthesized (1,3,4-thiadiazolylthiaazaspiro[4.5]decane and thiazolopyrimidinethione compounds were synthesized by glycosylation reactions using acetylated glycosyl bromides. The anticancer activity of synthesized compounds was studied against the cell culture of HepG-2 (human liver hepatocellular carcinoma, PC-3 (human prostate adenocarcinoma and HCT116 (human colorectal carcinoma cell lines and a number of compounds showed moderate to high inhibition activities.

Attributes for NHDplus Catchments (Version 1.1) for the Conterminous United States: Population Density, 2000

Science.gov (United States)

Wieczorek, Michael; LaMottem, Andrew E.

2010-01-01

This data set represents the average population density, in number of people per square kilometer multiplied by 10 for the year 2000, compiled for every catchment of NHDPlus for the conterminous United States. The source data set is the 2000 Population Density by Block Group for the Conterminous United States (Hitt, 2003). The NHDPlus Version 1.1 is an integrated suite of application-ready geospatial datasets that incorporates many of the best features of the National Hydrography Dataset (NHD) and the National Elevation Dataset (NED). The NHDPlus includes a stream network (based on the 1:100,00-scale NHD), improved networking, naming, and value-added attributes (VAAs). NHDPlus also includes elevation-derived catchments (drainage areas) produced using a drainage enforcement technique first widely used in New England, and thus referred to as "the New England Method." This technique involves "burning in" the 1:100,000-scale NHD and when available building "walls" using the National Watershed Boundary Dataset (WBD). The resulting modified digital elevation model (HydroDEM) is used to produce hydrologic derivatives that agree with the NHD and WBD. Over the past two years, an interdisciplinary team from the U.S. Geological Survey (USGS), and the U.S. Environmental Protection Agency (USEPA), and contractors, found that this method produces the best quality NHD catchments using an automated process (USEPA, 2007). The NHDPlus dataset is organized by 18 Production Units that cover the conterminous United States. The NHDPlus version 1.1 data are grouped by the U.S. Geologic Survey's Major River Basins (MRBs, Crawford and others, 2006). MRB1, covering the New England and Mid-Atlantic River basins, contains NHDPlus Production Units 1 and 2. MRB2, covering the South Atlantic-Gulf and Tennessee River basins, contains NHDPlus Production Units 3 and 6. MRB3, covering the Great Lakes, Ohio, Upper Mississippi, and Souris-Red-Rainy River basins, contains NHDPlus Production Units 4, 5

1.45 Å resolution structure of SRPN18 from the malaria vector Anopheles gambiae

Energy Technology Data Exchange (ETDEWEB)

Meekins, David A.; Zhang, Xin; Battaile, Kevin P.; Lovell, Scott; Michel, Kristin (Kansas); (KSU); (HWMRI)

2016-11-19

Serine protease inhibitors (serpins) in insects function within development, wound healing and immunity. The genome of the African malaria vector,Anopheles gambiae, encodes 23 distinct serpin proteins, several of which are implicated in disease-relevant physiological responses.A. gambiaeserpin 18 (SRPN18) was previously categorized as non-inhibitory based on the sequence of its reactive-center loop (RCL), a region responsible for targeting and initiating protease inhibition. The crystal structure ofA. gambiaeSRPN18 was determined to a resolution of 1.45 Å, including nearly the entire RCL in one of the two molecules in the asymmetric unit. The structure reveals that the SRPN18 RCL is extremely short and constricted, a feature associated with noncanonical inhibitors or non-inhibitory serpin superfamily members. Furthermore, the SRPN18 RCL does not contain a suitable protease target site and contains a large number of prolines. The SRPN18 structure therefore reveals a unique RCL architecture among the highly conserved serpin fold.

N-acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of 2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

DEFF Research Database (Denmark)

Frandsen, Henrik Lauritz; Alexander, J.

2000-01-01

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. PhIP is metabolically activated to the ultimate mutagenic metabolite by CYP P450-mediated N-hydroxylation followed by phase II esterification, Incubation of N...

Biocatalytic ammonolysis of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester: preparation of an intermediate to the dipeptidyl peptidase IV inhibitor Saxagliptin.

Science.gov (United States)

Gill, Iqbal; Patel, Ramesh

2006-02-01

An efficient biocatalytic method has been developed for the conversion of (5S)-4,5-dihydro-1H-pyrrole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl)-5-ethyl ester (1) into the corresponding amide (5S)-5-aminocarbonyl-4,5-dihydro-1H-pyrrole-1-carboxylic acid, 1-(1,1-dimethylethyl)ester (2), which is a critical intermediate in the synthesis of the dipeptidyl peptidase IV (DPP4) inhibitor Saxagliptin (3). Candida antartica lipase B mediates ammonolysis of the ester with ammonium carbamate as ammonia donor to yield up to 71% of the amide. The inclusion of Ascarite and calcium chloride as adsorbents for carbon dioxide and ethanol byproducts, respectively, increases the yield to 98%, thereby offering an efficient and practical alternative to chemical routes which yield 57-64%.

26 CFR 1.953-2 - Actual United States risks.

Science.gov (United States)

2010-04-01

... being the promotion of such sales to United States retail outlets by advertising in trade publications... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Actual United States risks. 1.953-2 Section 1.953-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

1,25 (OH)2 vitamin D3-induced 45Ca uptake in vascular myocytes cultured from spontaneously hypertensive and normotensive rats

International Nuclear Information System (INIS)

Xue, Hong; McCarron, D.A.; Bukoski, R.D.

1991-01-01

The effect of 1,25 (OH) 2 vitamin D 3 on basal 45 Ca uptake was examined in vasvular smooth muscle cells cultured from mesenteric arteries of spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) normotensive rats. Basal uptake of 45 Ca was significantly greater in myocytes of WKY than SHR at 5, 10, 30 and 60 min incubation with the isotope. Incubation with 1 ng/ml 1,25 (OH) 2 vitamin D 3 for 48 hr increased basal 45 Ca uptake between 1-10 min in SHR and between 5-10 min in WKY. The dose-response relationship indicated that cells from both strains are equally sensitive to the calciotropic effects of 1,25 (OH) 2 vitamin D 3 with half-maximal stimulation occurring at approximately 0.3-0.4 ng/ml. In cells of both strains maximal stimulation of 45 Ca uptake was achieved only after a 12-24 hr period of incubation with hormone and pretreatment with cycloheximide inhibited 1,24 (OH) 2 vitamin D 3 -enhanced 45 Ca uptake. Although 45 Ca binding by extracellular matrix material was significantly greater in WKY than SHR, 1,25 (OH) 2 vitamin D 3 had no effect on the amount of matrix 45 Ca binding in either strain

1,1′-{1,4-Phenylene bis[3-(6-chloro-2-methyl-4-phenylquinolin-3-yl-4,5-dihydro-1H-pyrazole-5,1-diyl]}dibutan-1-one

Directory of Open Access Journals (Sweden)

Allaoua Kedjadja

2015-10-01

Full Text Available A new polycyclic compound, 1,1′-{1,4-phenylene bis[3-(6-chloro-2-methyl-4-phenylquinolin-3-yl-4,5-dihydro-1H-pyrazole-5,1-diyl]}dibutan-1-one (3 has been synthesized by cyclocondensation of (2E,2′E-1,1′-bis(6-chloro-2-methyl-4-phenylquinolin-3-yl-3,3′-(1,4-phenylenediprop-2-en-1-one (2 and hydrazine hydrate in butanoic acid. The structure of this compound was established by elemental analysis, 1H-NMR, 13C-NMR, mass and IR spectroscopy.

MR cholangiopancreatography. Comparison of images obtained with 1.0 and 1.5 tesla units

International Nuclear Information System (INIS)

Yasui, Masayasu; Ito, Katsuyoshi; Koike, Shinji; Matsunaga, Naofumi

2002-01-01

The purpose of this study was to compare the image quality and visualization obtained in MR cholangiopancreatography (MRCP) using different high-field strength (1.0 vs. 1.5 Tesla) MR units and to assess the effect of field strength on MRCP. This study population included 10 healthy volunteers and 37 patients suspected of having pancreatobiliary diseases. MRCP images were obtained using two MR units with different high-field strengths (1.0 and 1.5 Tesla), with half-Fourier acquisition single-shot turbo spin-echo (HASTE) and rapid acquisition by relaxation enhancement (RARE) sequences. The image quality and visualization of each portion of the pancreatobiliary system were graded and recorded using a four-point scale. Additionally, the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured. The SNR and CNR in HASTE sequences acquired with the 1.5 Tesla (T) unit were significantly higher than those acquired with the 1.0 T unit (p=0.001). In qualitative analysis, there were no statistically significant differences in image quality or visualization of the ducts in either HASTE or RARE sequences between 1.0 T and 1.5 T. Our study showed that visual image quality provided by MRCP was equivalent at 1.0 and 1.5 T. (author)

45 CFR 501.3 - Service of process.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Service of process. 501.3 Section 501.3 Public... UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE SUBPOENAS, DEPOSITIONS, AND OATHS § 501.3 Service of process. (a) By whom served. The Commission will serve all orders, notices and other papers issued...

Experience of Ko-Ri Unit 1 water chemistry

International Nuclear Information System (INIS)

Tae Il Lee

1983-01-01

The main focus is placed on operational experience in secondary system water chemistry (especially the steam generator) of the Ko-Ri nuclear power plant Unit 1, Republic of Korea, but primary side chemistry is also discussed. The major concern of secondary water chemistry in a PWR is that the condition of the steam generator be well maintained. Full flow deep bed condensate polishers have recently been installed and operation started in July 1982. Boric acid treatment of the steam generator was stopped and only the all volatile treatment method was used thereafter. A review of steam generator integrity, the chemistry control programme, secondary water quality, etc. is considered to be of great value regarding the operation of Unit 1 and future units now under startup testing or construction in the Republic of Korea. (author)

Attributes for NHDPlus catchments (Version 1.1) for the conterminous United States: STATSGO soil characteristics

Science.gov (United States)

Wieczorek, Michael; LaMotte, Andrew E.

2010-01-01

This data set represents estimated soil variables compiled for every catchment of NHDPlus for the conterminous United States. The variables included are cation exchange capacity, percent calcium carbonate, slope, water-table depth, soil thickness, hydrologic soil group, soil erodibility (k-factor), permeability, average water capacity, bulk density, percent organic material, percent clay, percent sand, and percent silt. The source data set is the State Soil ( STATSGO ) Geographic Database (Wolock, 1997). The NHDPlus Version 1.1 is an integrated suite of application-ready geospatial datasets that incorporates many of the best features of the National Hydrography Dataset (NHD) and the National Elevation Dataset (NED). The NHDPlus includes a stream network (based on the 1:100,00-scale NHD), improved networking, naming, and value-added attributes (VAAs). NHDPlus also includes elevation-derived catchments (drainage areas) produced using a drainage enforcement technique first widely used in New England, and thus referred to as "the New England Method." This technique involves "burning in" the 1:100,000-scale NHD and when available building "walls" using the National Watershed Boundary Dataset (WBD). The resulting modified digital elevation model (HydroDEM) is used to produce hydrologic derivatives that agree with the NHD and WBD. Over the past two years, an interdisciplinary team from the U.S. Geological Survey (USGS), and the U.S. Environmental Protection Agency (USEPA), and contractors, found that this method produces the best quality NHD catchments using an automated process (USEPA, 2007). The NHDPlus dataset is organized by 18 Production Units that cover the conterminous United States. The NHDPlus version 1.1 data are grouped by the U.S. Geologic Survey's Major River Basins (MRBs, Crawford and others, 2006). MRB1, covering the New England and Mid-Atlantic River basins, contains NHDPlus Production Units 1 and 2. MRB2, covering the South Atlantic-Gulf and Tennessee

76 FR 40754 - Duke Energy Carolinas, LLC Catawba Nuclear Station, Units 1 and 2; McGuire Nuclear Station, Units...

Science.gov (United States)

2011-07-11

... NUCLEAR REGULATORY COMMISSION [NRC-2011-0100; Docket Nos. 50-413 and 50-414; Docket Nos. 50-369 and 50-370; Docket Nos. 50-269, 50-270, And 50-287] Duke Energy Carolinas, LLC Catawba Nuclear Station, Units 1 and 2; McGuire Nuclear Station, Units 1 and 2; Oconee Nuclear Station, Units 1, 2, and 3; Notice...

Synthesis and characterization of new 3-(4,5-dihydro-5-arylisoxazol-3-yl-4-hydroxyquinolin-2(1H-ones and 3-(4-styrylisoxazolo[4,5-c]quinolin-4(5H-one derivatives

Directory of Open Access Journals (Sweden)

S. Sarveswari

2016-09-01

Full Text Available The 4-hydroxy-3-(3-arylacryloylquinolin-2(1H-ones were synthesized from 3-acetyl-4-hydroxyquinolin-2(1H-one by microwave assisted synthesis, which in turn converted into their corresponding 3-(4,5-dihydro-5-arylisoxazol-3-yl-4-hydroxyquinolin-2(1H-ones and 3-(4-styrylisoxazolo[4,5-c]quinolin-4(5H-one derivatives.

Accident analysis of Fukushima Daiichi Nuclear Power Station unit 1

International Nuclear Information System (INIS)

Kobayashi, Masahide; Narabayashi, Tadashi; Tsuji, Masashi; Chiba, Go; Nagata, Yasunori; Shimoe, Tomohiro

2015-01-01

As a result of the Great East Japan Earthquake that occurred on 11 March 2011, all AC and DC power at the Fukushima Daiichi NPP units 1 to 3 were lost soon after the tsunami. The core cooling function was lost, and the cores of units 1 to 3 were damaged. The purpose of this work is to clarify the progress of the accident in unit 1, which was damaged the earliest among the 3 units. Therefore, an original severe accident analysis code was developed, and the progress of the accident was evaluated from the analysis results and the actual data. As a result, the leakage path from a pressure vessel was clarified, and some lessons and knowledge were gained. (author)

Safari Adventures: A Bibliography for Young Readers Preschool through Junior High.

Science.gov (United States)

Sumner, Mary Ann, Comp.

This annotated bibliography contains books for blind or physically handicapped youngsters from preschool through junior high. The books are available in braille, on audiocassette, or recorded discs. The approximately 400 titles listed were produced in Florida or obtained from the National Library Service for the Blind and Physically Handicapped.…

Evaluation of an Audio Cassette Tape Lecture Course

Science.gov (United States)

Blank, Jerome W.

1975-01-01

An audio-cassette continuing education course (Selected Topics in Pharmacology) from Extension Services in Pharmacy at the University of Wisconsin was offered to a selected test market of pharmacists and evaluated using a pre-, post-test design. Results showed significant increase in cognitive knowledge and strong approval of students. (JT)

The Cassette Tour: An Effective, Efficient Orientation.

Science.gov (United States)

Poirier, Gayle

1992-01-01

Describes the development, use, promotion, and student evaluation of a 25-minute audiocassette tour of the Louisiana State University library, which was developed as a pilot project by the bibliographic instruction librarian in 1990. Notes that student suggestions have been instrumental in the development of more tool and subject specific…

Radio Nutricion: A Program for Nutrition Education with the Hispanic Community. Service Provider's Guide = Radio Nutricion: Un Programa de Educacion para la Nutricion para la Comunidad Hispana. Guia del Proveeidor de Servicios.

Science.gov (United States)

Association of Farmworker Opportunity Program, Arlington, VA.

The set of materials was designed to provide nutrition instruction to Spanish-speaking farm workers using radio broadcasts. It includes audiocassette tapes of four novellas (mini-dramas) on nutrition-related topics (diabetes, heart disease and high blood pressure, pregnancy, smart shopping), talk shows on the same topics, a public service…

Benzo[1,2-b:4,5-b’]dithiophene-Pyrido[3,4-b]pyrazine Small-Molecule Donors for Bulk Heterojunction Solar Cells

KAUST Repository

Wolf, Jannic Sebastian; Babics, Maxime; Wang, Kai; Saleem, Qasim; Liang, Ru-Ze; Hansen, Michael Ryan; Beaujuge, Pierre

2016-01-01

We report on the synthesis, material properties and BHJ solar cell characteristics of a set of π-conjugated small-molecule (SM) donors composed of benzo[1,2-b:4,5-b′]dithiophene (BDT) and pyrido[3,4-b]pyrazine (PP) units – examining the perspectives of alkyl-substituted PP acceptor motifs in SM designs. In these systems (SM1-4), both the type of side chains derived from the PP motifs and the presence of ring-substituents on BDT critically impact (i) molecular packing, and (ii) thin-film morphologies and charge transport in BHJ solar cells. With the appropriate side-chain pattern, the ring-substituted analogue SM4 stands out: achieving efficiencies of ca. 6.5% with PC71BM, and fine-scale morphologies comparable to those obtained with some of the best-performing polymer donors in BHJ solar cells. 1H-1H DQ-SQ NMR analyses are used to examine the distinct self-assembly pattern of SM4, expected to factor into the development of the BHJ morphology.

Benzo[1,2-b:4,5-b’]dithiophene-Pyrido[3,4-b]pyrazine Small-Molecule Donors for Bulk Heterojunction Solar Cells

KAUST Repository

Wolf, Jannic Sebastian

2016-01-22

We report on the synthesis, material properties and BHJ solar cell characteristics of a set of π-conjugated small-molecule (SM) donors composed of benzo[1,2-b:4,5-b′]dithiophene (BDT) and pyrido[3,4-b]pyrazine (PP) units – examining the perspectives of alkyl-substituted PP acceptor motifs in SM designs. In these systems (SM1-4), both the type of side chains derived from the PP motifs and the presence of ring-substituents on BDT critically impact (i) molecular packing, and (ii) thin-film morphologies and charge transport in BHJ solar cells. With the appropriate side-chain pattern, the ring-substituted analogue SM4 stands out: achieving efficiencies of ca. 6.5% with PC71BM, and fine-scale morphologies comparable to those obtained with some of the best-performing polymer donors in BHJ solar cells. 1H-1H DQ-SQ NMR analyses are used to examine the distinct self-assembly pattern of SM4, expected to factor into the development of the BHJ morphology.

Biodistribution of Yttrium-90-Labeled Anti-CD45 Antibody in a Nonhuman Primate Model

International Nuclear Information System (INIS)

Nemecek, Eneida; Hamlin, Donald K.; Fisher, Darrell R.; Krohn, Kenneth A.; Pagel, John M.; Applebaum, F. R.; Press, Oliver W.; Matthews, Dana C.

2005-01-01

Radioimmunotherapy may improve the outcome of hematopoietic cell transplantation for hematologic malignancies by delivering targeted radiation to hematopoietic organs while relatively sparing nontarget organs. We evaluated the organ localization of yttrium-90-labeled anti-CD45 (90Y-anti-CD45) antibody in macaques, a model that had previously predicted iodine-131-labeled anti-CD-45 (131I-anti-CD45) antibody biodistribution in humans. Experimental Design: Twelve Macaca nemestrina primates received anti-CD45 antibody labeled with 1 to 2 mCi of 90Y followed by serial blood sampling and marrow and lymph node biopsies, and necropsy. The content of 90Y per gram of tissue was determined by liquid scintillation spectrometry. Time-activity curves were constructed using average isotope concentrations in each tissue at measured time points to yield the fractional residence time and estimate radiation absorbed doses for each organ per unit of administered activity. The biodistribution of 90Y-anti-CD45 antibody was then compared with that previously obtained with 131I-anti-CD45 antibody in macaques. Results: The spleen received 2,120, marrow 1,060, and lymph nodes 315 cGy/mCi of 90Y injected. The liver and lungs were the nontarget organs receiving the highest radiation absorbed doses (440 and 285 cGy/mCi, respectively). Ytrrium-90-labeled anti-CD45 antibody delivered 2.5- and 3.7-fold more radiation to marrow than to liver and lungs, respectively. The ratios previously observed with 131I-antiCD45 antibody were 2.5-and 2.2-fold more radiation to marrow than to liver and lungs, respectively. Conclusions: This study shows that 90Y-anti-CD45 antibody can deliver relatively selective radiation to hematopoietic tissues, with similar ratios of radiation delivered to target versus nontarget organs, as compared with the 131I immunoconjugate in the same animal model

22 CFR 142.45 - Housing.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Housing. 142.45 Section 142.45 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 142.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall provide...

22 CFR 217.45 - Housing.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Housing. 217.45 Section 217.45 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 217.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall provide...

Synthesis of New Unsymmetrical 4,5-Dihydroxy-2-imidazolidinones. Dynamic NMR Spectroscopic Study of the Prototropic Tautomerism in 1-(2-Benzimidazolyl-3-phenyl-4,5-dihydroxy-2-imidazolidinone

Directory of Open Access Journals (Sweden)

Farshid Salimi

2006-10-01

Full Text Available The acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueousglyoxal with N-heteroaryl-N'-phenylureas 4a-f (heteroaryl = 2-thiazolyl, 2-pyrimidinyl,2-pyrazinyl, 2-pyridinyl, 3-pyridinyl and 2-benzimidazolyl led to the formation of thecorresponding 1-heteroaryl-3-phenyl-4,5-dihydroxy-2-imidazolidinones 5a-f. All theproducts were characterized by elemental and spectroscopic analyses. The free-energybarrier (∆GP≠ for prototropic tautomerism in 1-(2-benzimidazolyl-3-phenyl-4,5-dihydroxy-2-imidazolidinone (5f was determined by dynamic NMR studies to be 81 ± 2KJ molP-1

9-Furfurylidene-2,3-dimethyl-6,7,8,9-tetrahydro-4H-thieno[2′,3′:4,5]pyrimidino[1,2-a]pyridin-4-one

Directory of Open Access Journals (Sweden)

Khusnutdin M. Shakhidoyatov

2010-03-01

Full Text Available The title compound, C17H16N2O2S, was obtained by condensation of 2,3-dimethylthieno[2′,3′:4,5]pyrimidino[1,2-a]pyridin-4-one with furfural in the presence of sodium hydroxide. One of the methylene groups of the tetrahydropyrido ring is disordered over two positions in a 0.87 (1:0.13 (1 ratio. The thieno[2,3-d]pyrimidin-4-one unit and the furan ring are both planar (r.m.s. deviation = 0.535 Å, and coplanar with each other, forming a dihedral angle of 5.4 (1°. Four weak intermolecular hydrogen bonds (C—H...O and C—H...N are observed in the structure, which join molecules into a network parallel to (101.

34 CFR 104.45 - Housing.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Housing. 104.45 Section 104.45 Education Regulations of... Postsecondary Education § 104.45 Housing. (a) Housing provided by the recipient. A recipient that provides housing to its nonhandicapped students shall provide comparable, convenient, and accessible housing to...

28 CFR 45.1 - Cross-reference to ethical standards and financial disclosure regulations.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Cross-reference to ethical standards and...) EMPLOYEE RESPONSIBILITIES § 45.1 Cross-reference to ethical standards and financial disclosure regulations. Employees of the Department of Justice are subject to the executive branch-wide Standards of Ethical Conduct...

The differences in RCAS1 and DFF45 endometrial expression between late proliferative, early secretory, and mid-secretory cycle phases.

Directory of Open Access Journals (Sweden)

Jerzy Sikora

2008-04-01

Full Text Available RCAS1 expression is related to the regulation of activated immune cells and to connective tissue remodeling within the endometrium. DFF45 seems to play an important role in the apoptotic process, most likely by acting through the regulation of DNA fragmentation. Its expression changes within the endometrium seem to be related to the resistance of endometrial cells to apoptosis. The aim of the present study was to evaluate RCAS1 and DFF45 endometrial expressions during ovulation and the implantation period. RCAS1 and DFF45 expression was assessed by the Western-blot method in endometrial tissue samples obtained from 20 patients. The tissue samples were classified according to the menstrual cycle phases in which they were collected, with a division into three phases: late proliferative, early secretory, and mid-secretory. The lowest level of RCAS1 and the highest level of DFF45 endometrial expression was found during the early secretory cycle phase. Statistically significantly higher RCAS1 and statistically significantly lower DFF45 endometrial expression was identified in the endometrium during the late proliferative as compared to the early secretory cycle phase. Moreover, statistically significantly higher RCAS1 and statistically significantly lower DFF45 expression was found in the endometrium during the mid-secretory as compared to the early secretory cycle phase. The preparation for implantation process in the endometrium is preceded by dynamic changes in endometrial ECM and results from the proper interaction between endometrial and immune cells. The course of this process is conditioned by the immunomodulating activity of endometrial cells and their resistance to immune-mediated apoptosis. These dynamic changes are closely related to RCAS1 and DFF45 expression alterations.

Developing BlackBerry Tablet Applications with Flex 45

CERN Document Server

Tretola, Rich

2011-01-01

Ready to put your ActionScript 3 skills to work on mobile apps? This hands-on book walks you through the process of creating an Adobe AIR application for Blackberry Tablets from start to finish, using the Flex 4.5 framework. Move quickly from a basic Hello World application to complex interactions with Blackberry APIs, and get complete code examples for working with tablet components-including the accelerometer, GPS unit, camera, file system, and multitouch screen. This is an ideal resource no matter how much Flex experience you have. Use Flash Builder 4.5 to create and debug a Flex Mobile pr

Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in E mu-pim-1 transgenic mice

DEFF Research Database (Denmark)

Sørensen, Ilona Kryspin; Mortensen, Alicja; Kristiansen, E.

1996-01-01

The usefulness of transgenic E mu-pim-1 mice over-expressing the pim-1 oncogene in lymphoid tissues, as sensitive test organisms was studied in a short-term carcinogenicity study. The mice were fed standard diet Altromin 1314 supplemented either with 0.03% 2-amino-1-methyl-6-phenylimidazo[4,5-b......]pyridine (PhIP) for 7 months or with 0.03% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for 6 months, PhIP and IQ are heterocyclic amines formed during cooking of meat and fish and are mutagenic to bacteria and cultured mammalian cells, PhIP is a potent mouse lymphomagen, while IQ is a liver carcinogen...... to non-transgenic mice. Our results suggest that the transgenic E mu-pim-1 mouse may be a useful model for short-term carcinogenicity screening of potential genotoxic carcinogens having the lymphoid system as target tissue, The carcinogen IQ which does not have the lymphoid system as a target...

Permeability and giant magnetoimpedance in Co69Fe4.5X1.5Si10B15 (X=Cr, Mn, Ni) amorphous ribbons

International Nuclear Information System (INIS)

Byon, Kwang Seok; Yu, Seong-Cho; Kim, Cheol Gi

2001-01-01

The magnetoimpedance (MI) has been measured in the amorphous ribbons of the soft ferromagnetic alloy Co 69 Fe 4.5 X 1.5 Si 10 B 15 (X=Cr, Mn, Ni) as functions of frequency (f). For all of the three samples, at low frequency, f≤5MHz, the MI ratio increases with increasing frequency, but the MI ratio decreases at high frequency, f≥5MHz. The MI profiles are not changed at low frequency regions of f≤1MHz in the amorphous ribbons. The MI ratio at high frequency of f=5MHz becomes 57% in Co 69 Fe 4.5 Cr 1.5 Si 10 B 15 , but the MI ratio becomes 30% in Co 69 Fe 4.5 Mn 1.5 Si 10 B 15 and Co 69 Fe 4.5 Ni 1.5 Si 10 B 15 . The MI ratio at f=10MHz becomes 45% in Co 69 Fe 4.5 Cr 1.5 Si 10 B 15 and the MI ratio becomes 23% in Co 69 Fe 4.5 Mn 1.5 Si 10 B 15 and Co 69 Fe 4.5 Ni 1.5 Si 10 B 15 , respectively. The maximum values of field sensitivity are 2.7(X=Cr), 2.5(X=Mn), 2.2(X=Ni)%/Oe for f=5MHz. [copyright] 2001 American Institute of Physics

19 CFR 210.45 - Review of initial determinations on matters other than temporary relief.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false Review of initial determinations on matters other than temporary relief. 210.45 Section 210.45 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Determinations and...

26 CFR 1.953-3 - Risks deemed to be United States risks.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Risks deemed to be United States risks. 1.953-3... TAX (CONTINUED) INCOME TAXES Controlled Foreign Corporations § 1.953-3 Risks deemed to be United States risks. (a) Artificial arrangements. For purposes of paragraph (a) of § 1.953-1, the term “United...

45 CFR 301.1 - General definitions.

Science.gov (United States)

2010-10-01

... Child Support Enforcement which is the separate organizational unit within the Department with the... Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT... 66 percent. Assigned support obligation means, unless otherwise specified, any support obligation...

Level 1 shutdown and low power operation of Mochovce NPP, Unit 1, Slovakia

International Nuclear Information System (INIS)

Halada, P.; Cillik, I.; Stojka, T.; Kuzma, M.; Prochaska, J.; Vrtik, L.

2004-01-01

The paper presents general approach, used methods and form of documentation of the results that have been applied within the shutdown and low power PSA (SPSA) study for Mochovce NPP, Unit 1, Slovakia. The SPSA project was realized by VUJE Trnava Inc., Slovakia in 2001-2002 years. The Level 1 SPSA study for Mochovce NPP Unit 1 covers internal events as well as internal (fires, floods and heavy load drop) and external (aircraft crash, extreme meteorological conditions, seismic event and influence of surrounding industry) hazards. Mochovce NPP consists of two operating units equipped with VVER 440/V213 reactors safety upgraded before construction finishing and operation start. 87 safety measures based on VVER 440 operational experience and international mission insights were implemented to enhance its operational and nuclear safety. The SPSA relates to full power PSA (FPSA) as a continuation of the effort to create a harmonized level 1 PSA model for all operational modes of the plant with the goal to use it for further purposes as follows: Real Time Risk Monitor, Maintenance Optimization, Technical Specifications Optimization, Living PSA. (author)

45 CFR 706.1 - Cross-references to employee ethical conduct standards, financial disclosure and financial...

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Cross-references to employee ethical conduct... 706.1 Public Welfare Regulations Relating to Public Welfare (Continued) COMMISSION ON CIVIL RIGHTS EMPLOYEE RESPONSIBILITIES AND CONDUCT § 706.1 Cross-references to employee ethical conduct standards...

Quad-Cities Station, Units 1 and 2. Annual report, 1975

International Nuclear Information System (INIS)

1976-01-01

Net electrical power generated by Unit 1 was 2,246,757 MWh(e) with the generator on line 4,287.5 hrs while Unit 2 generated 1,729,147 MWh(e) with the generator on line 3,056.21 hrs. Information is presented concerning operations, power generation, shutdowns, maintenance, changes, tests, and experiments

24 CFR 28.45 - Settlements.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Settlements. 28.45 Section 28.45... IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 28.45 Settlements. (a) HUD and the respondent may enter into a settlement agreement at any time prior to the issuing of a notice of final...

SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITIES OF NOVEL 1-(MORPHOLINE-4-YL-METHYL-3-ALKYL(ARYL-4-[4-(DIMETHYLAMINO-BENZYLIDENAMINO]-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-5-ONES

Directory of Open Access Journals (Sweden)

Özlem Gürsoy Kol

2016-08-01

Full Text Available In this paper, eight novel 1-(morpholine-4-yl-methyl-3-alkyl(aryl-4-[4-(dimethylamino-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (2 were obtained by the reactions of 3-alkyl(aryl-4-[4-(dimethylamino-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (1 with formaldehyde and morpholine. The novel synthesized compounds were identified by IR, 1H NMR and 13C NMR spectral data. Besides, the newly synthesized compounds were analysed for their in vitro potential antioxidant capacities in three different assays. All of the compounds demonstrated significant activity for metal chelating effect.

45 CFR 503.2 - General policies-Privacy Act.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false General policies-Privacy Act. 503.2 Section 503.2... THE UNITED STATES, DEPARTMENT OF JUSTICE RULES OF PRACTICE PRIVACY ACT AND GOVERNMENT IN THE SUNSHINE REGULATIONS Privacy Act Regulations § 503.2 General policies—Privacy Act. The Commission will protect the...

48 CFR 45.106 - Transferring accountability.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transferring accountability. 45.106 Section 45.106 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 45.106 Transferring accountability. Government property...

Biota of the 300-FF-1 operable unit. [Westinghouse Hanford Company

Energy Technology Data Exchange (ETDEWEB)

Rickard, W.H. Jr.; Fitzner, R.E.; Brandt, C.A.

1990-10-01

This report summarizes Task 5a-2 of the Phase I Remedial Investigation -- Operable Unit Characterization of the 300-FF-1 Operable Unit on the Hanford Site, near Richland, Washington. The ultimate goal of Phase I is to determine the nature and extent of the threat to public health and the environment from releases of hazardous substances from the operable unit. The purpose of Task 5a-2 was to determine what species inhabit the 300-FF-1 Operable Unit and how they use the unit. The focus is on those species listed as endangered or threatened, those that are economically important, or those that constitute significant components of the human food chain. 39 refs., 5 figs., 5 tabs.

Syntheses and structures of three supramolecular complexes based on 2-(pyridine-2-yl)-1H-imidazole-4,5-dicarboxylic acid

Science.gov (United States)

Yu, Xiao-Yang; Zhang, Xiao; Liu, Zhi-Gang; Cui, Xiao-Bing; Xu, Jia-Ning; Luo, Yu-Hui

2017-11-01

Three new supramolecular compounds, [Cu(o-HPIDC)(bpy)(H2O)]·2H2O 1, [Cu(o-H2PIDC)(phen)Cl]·[Cu(phen)2Cl]·10H2O·Cl 2 and {[Cd(o-H2PIDC)(H2O)2Cl]·H2O}23 (o-H3PIDC = 2-(pyridine-2-yl)-1H-imidazole-4,5-dicarboxylic acid, bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline), were hydrothermally synthesized and characterized. In compound 1, the adjacent two supramolecular layers are constructed from different types of helical chains with the same pitch. In compound 2, the adjacent 2D water-chloride layers, {[(H2O)10Cl]-}n, are pillared by [Cu(o-H2PIDC)(phen)Cl] units to form the overall 3D supramolecular network with 1D channels through Osbnd H⋯O hydrogen bond interactions. In compound 3, two Cd(II) are linked into a binuclear [Cd2(o-H2PIDC)2(H2O)4Cl2] with a ten-membered ring by two o-H2PIDC- ligands. The three compounds self-assemble into 3D supramolecular structures via hydrogen bond and π-π stacking interactions. The fluorescence properties of compound 3 was also investigated.

Conformance to Regulatory Guide 1.97, Arkansas Nuclear One, Unit No. 1

International Nuclear Information System (INIS)

Stoffel, J.W.

1985-08-01

This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97 for Unit No. 1 of Arkansas Nuclear One and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

Drie nuwe verklaringsopsies in die Jakobusbrief (Jak 2:1; 4:5; 5:6 ...

African Journals Online (AJOL)

New options in the understanding of the Epistle of James (Js 2:1; 4:5; 5:6) New methods of interpretation occasionally lead to new options in the understanding of texts. In the case of the Epistle of James, the interpretation has until recently stood under the spell of the 'comparative' method of Dibelius. Greater emphasis on ...

Level 1 PSA study of Mochovce unit 1 NPP (SM AA 10 and 08)

International Nuclear Information System (INIS)

Cillik, I.

1997-01-01

This paper presents genesis of Level 1 PSA project preparation for all operational modes of Mochovce NPP unit 1 including the description of its' main objectives, scope and working method. The PSA study which includes full power (FPSA) as well as shutdown and low power conditions (SPSA) Level 1 PSA has to support the nuclear safety improvements of the unit. They evaluate the basic design and the benefits of all improvements, which were found necessary to be incorporated before the start-up of the unit. The study includes internal events (transients and under-loss of coolant accident, LOCAs), internal hazards as fires and floods and selected external hazards as earthquake, influence of external industry, extreme meteorological conditions and aircraft crash.The PSA (both FPSA and SPSA) models is developed using the RISK SPECTRUM PSA code. (author)

Misfit dislocations of anisotropic magnetoresistant Nd0.45Sr0.55MnO3 thin films grown on SrTiO3 (1 1 0) substrates

International Nuclear Information System (INIS)

Tang, Y.L.; Zhu, Y.L.; Meng, H.; Zhang, Y.Q.; Ma, X.L.

2012-01-01

Nd 0.45 Sr 0.55 MnO 3 is an A-type antiferromagnetic manganite showing obvious angular-dependent magnetoresistance, which can be tuned by misfit strain. The misfit strain relaxation of Nd 0.45 Sr 0.55 MnO 3 thin films is of both fundamental and technical importance. In this paper, microstructures of epitaxial Nd 0.45 Sr 0.55 MnO 3 thin films grown on SrTiO 3 (1 1 0) substrates by pulsed laser deposition were investigated by means of (scanning) transmission electron microscopy. The Nd 0.45 Sr 0.55 MnO 3 thin films exhibit a two-layered structure: a continuous perovskite layer epitaxial grown on the substrate followed by epitaxially grown columnar nanostructures. An approximately periodic array of misfit dislocations is found along the interface with line directions of both 〈1 1 1〉 and [0 0 1]. High-resolution (scanning) transmission electron microscopy reveals that all the misfit dislocations possess a〈1 1 0〉-type Burgers vectors. A formation mechanism based on gliding or climbing of the dislocations is proposed to elucidate this novel misfit dislocation configuration. These misfit dislocations have complex effects on the strain relaxation and microstructure of the films, and thus their influence needs further consideration for heteroepitaxial perovskite thin film systems, especially for films grown on substrates with low-symmetry surfaces such as SrTiO 3 (1 1 0) and (1 1 1), which are attracting attention for their potentially new functions.

Comparison of ketorolac 0.45% versus diclofenac 0.1% for macular thickness and volume after uncomplicated cataract surgery.

Science.gov (United States)

Lee, Tae Hee; Choi, Won; Ji, Yong Sok; Yoon, Kyung Chul

2016-05-01

To compare the effects of ketorolac 0.45% and diclofenac 0.1% on macular thickness and volume after uncomplicated cataract surgery. A total of 76 eyes of 76 patients who underwent uncomplicated cataract surgery were included. Patients were treated with either diclofenac 0.1% (38 eyes) or ketorolac 0.45% (38 eyes) after surgery. The macular thickness and volume were obtained with optical coherence tomography (OCT). Central subfield thickness (CST, OCT 1 mm zone), total foveal thickness (TFT, OCT 3 mm zone), total macular thickness (TMT, OCT 6 mm zone), average macular thickness (AMT) and total macular volume (TMV) were compared between the two study groups. No significant differences between groups were found in macular thickness or volume 1 month after cataract surgery. Two months after surgery, the ketorolac group had significantly lower CST, TFT, TMT and AMT than the diclofenac group (p diclofenac group. Following uncomplicated cataract surgery, topical ketorolac 0.45% was more effective than diclofenac 0.1% in preventing increases in macular thickness and volume. © 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

100-KR-1 Operable Unit focused feasibility study report

International Nuclear Information System (INIS)

1994-11-01

The standard Comprehensive Environmental Response, Compensation, and Liability Act of 1980 Feasibility Study (FS) includes development and screening of alternatives and the detailed analysis of alternatives. This focused feasibility study (FFS) was conducted for the 100-KR-1 Operable Unit at the Hanford Site in southeastern Washington. The objective of this operable unit-specific FFS is to provide decision makers with sufficient information to allow appropriate and timely selection of interim remedial measures (IRM) for the five sites (116-K-1 crib, 116-K-2 trench, 116-KE-4 and 116-KW-3 retention basins, and process effluent pipelines) associated with the 100-KR-1 Operable Unit. The IRM candidate waste sites are determined in the limited field investigation. Site profiles are developed for each of these waste site. The site profiles are used in the application of the plug-in approach. The waste site either plugs into the analysis of the alternatives for the group, or deviations from the developed group alternatives are described and documented

Computer systems for the control of teletherapy units

International Nuclear Information System (INIS)

Brace, J.A.

1985-01-01

This paper describes a computer-controlled tracking cobalt unit installed at the Royal Free Hospital. It is based on a standard TEM MS90 unit and operates at 90-cm source-axis distance with a geometric field size of 45 x 45 cm at that distance. It has been modified so that it can be used either manually or under computer control. There are nine parameters that can be controlled positionally and two that can be controlled in rate mode; these are presented in a table

46 CFR 25.45-1 - Heating and lighting systems on vessels carrying passengers for hire.

Science.gov (United States)

2010-10-01

... UNINSPECTED VESSELS REQUIREMENTS Cooking, Heating, and Lighting Systems § 25.45-1 Heating and lighting systems...) Alcohol, solid, (2) Alcohol, liquid, combustible, (3) Fuel oil, No. 1, No. 2, or No. 3, (4) Kerosene, (5) Wood or, (6) Coal. (b) Heating and lighting systems using alcohol must meet the following requirements...

26 CFR 1.989(a)-1 - Definition of a qualified business unit.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Definition of a qualified business unit. 1.989... definition of the term “qualified business unit” (QBU) within the meaning of section 989. (2) Effective date... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Export Trade Corporations § 1.989(a)-1 Definition of a...

40 CFR 31.45 - Quality assurance.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Quality assurance. 31.45 Section 31.45... Requirements Reports, Records, Retention, and Enforcement § 31.45 Quality assurance. If the grantee's project... quality assurance practices consisting of policies, procedures, specifications, standards, and...

45 CFR 1626.5 - Alien status and eligibility.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Alien status and eligibility. 1626.5 Section 1626... RESTRICTIONS ON LEGAL ASSISTANCE TO ALIENS § 1626.5 Alien status and eligibility. Subject to all other... may provide legal assistance to an alien who is present in the United States and who is within one of...

20 CFR 229.45 - Employee benefit.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employee benefit. 229.45 Section 229.45 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Computation of the Overall Minimum Rate § 229.45 Employee benefit. The original...

40 CFR 503.45 - Management practices.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Management practices. 503.45 Section 503.45 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STANDARDS FOR THE USE OR DISPOSAL OF SEWAGE SLUDGE Incineration § 503.45 Management practices. (a)(1) An...

⁴⁵Ti extraction using hydroxamate resin

DEFF Research Database (Denmark)

Gagnon, K.; Severin, Gregory; Barnhart, T. E.

2012-01-01

As an attractive radionuclide for positron emission tomography, this study explores the extraction and reactivity of 45Ti produced via the 45Sc(p,n)45Ti reaction on a GE PETtrace. Using a small hydroxamate column, we have demonstrated an overall recovery of >50% of 45Ti in ~1 mL of 1M oxalic acid...

37 CFR 1.416 - The United States International Preliminary Examining Authority.

Science.gov (United States)

2010-07-01

... STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL RULES OF PRACTICE IN PATENT CASES International Processing Provisions General Information § 1.416 The United States International Preliminary... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false The United States...

S-band 45 MW peak power test facility at RRCAT

International Nuclear Information System (INIS)

Wanmode, A. Yashwant; Reddy, Sivananda; Mulchandani, J.; Mohania, Praveen; Shrivastava, B. Purushottam

2015-01-01

RRCAT is engaged in the design and development of high energy electron LINAC as future injectors for the Booster Synchrotron for Indus-1 and Indus-2 SRS. The high energy LINAC will need microwave power over 30 MW depending on the number of structures to be energized. In order to have advance preparations for this development a 45 MW S-Band test facility has been designed and developed at RRCAT. The test stand is built around a 45 MW peak power S-band pulsed klystron, A conventional pulse forming network based modulator for klystron has been designed and developed. The WR-284 waveguide transmission system consisting of dual directional couplers, SF 6 gas pressurization unit, high power waveguide load and arc sensor has been developed and interfaced with the klystron. The klystron has been successfully tested up to 30 MW peak power at 2856 MHz on SF 6 pressurized waveguide line. A solid state S Band driver amplifier up to 1 kW output power was designed developed for driving the klystron. This paper describes the results of 30 MW peak power test of this facility. (author)

45 CFR 400.94 - Determination of eligibility for Medicaid.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Determination of eligibility for Medicaid. 400.94... Determination of eligibility for Medicaid. (a) The State must determine Medicaid and SCHIP eligibility under its Medicaid and SCHIP State plans for each individual member of a family unit that applies for medical...

45 CFR 2543.45 - Cost and price analysis.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Cost and price analysis. 2543.45 Section 2543.45... ORGANIZATIONS Post-Award Requirements Property Standards § 2543.45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every...

49 CFR 89.45 - Department determination.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Department determination. 89.45 Section 89.45... Referral of Debts to IRS for Tax Refund Offset § 89.45 Department determination. (a) Following review of... supporting rationale. (b) If the Department either sustains or amends its determination, it shall notify the...

27 CFR 4.5 - Related regulations.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Related regulations. 4.5 Section 4.5 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF WINE Scope § 4.5 Related regulations. The following...

Rest lifetime evaluation and ageing management in NPP 'Kozloduy' unit 1-4

International Nuclear Information System (INIS)

Erve, M.; Heck, R.; Schmidt, J.; Daum, G.; Bataklieva, L.; Stoev, M.

1999-01-01

In 1992 as a result of an IAEA SRM review the 'WANO 6-month program' has been issued to improve operation, maintenance nad safety culture for the four WWER 440/230 units at the NPP 'Kozloduy' Siemens has awarded 3 contracts related to RTL evaluation of the main equipment, integrity of reactor pressure vessel and to the leak-before-break behaviour of the main piping od unit 2. It is pursuit an overall strategy that allows to: implement on the basis of RTL evaluation a long term ageing management program (AMAP) for Kozloduy's units 1-4 to assure their operation until the end of their design life; identify those components and equipment for which from the safety point of view urgent and immediate actions have to be performed; increase step by step the safety and reliability according to the Western standards and to internationally accepted safety culture; keep open the possibility of life extension as far as this would be technically feasible and acceptable and economically reasonable. Under the technical leadership of Siemens studies have been performed related to the subject of integrity and RTL, such as: reirradiation of RPV samples from Unit 1 and 2; evaluation of PV embrittlement of Unit 1; transfer of the results of LBB assessment of Unit 2 to Units 1, 3 and 4; transfer of results of RTL evaluation of Unit 2 to Units 1, 3 and 4; PTS analysis of RPV of Unit 1, 2,3 and 4. The main remarkable results are: no life-limiting mechanisms detected, requiring immediate actions, except for RPVs; residual lifetime determined for RPVs on reliable basis of advanced modern PTS analysis and sample testing; necessary activities in monitoring of ageing and in-service inspection clearly identified successful proof of lBB for main primary piping after slight modification of supports; international experts agreement reached (e.g. Risk Audit, successful IAEA experts meetings and OSART missions)

Safety analysis report for decommissioning of KNPP units 1 and 2

International Nuclear Information System (INIS)

Ivanova, A.; Ovcharova, I.

2008-01-01

At present units 1 and 2 possess a license for operation in mode „E‟ – storage of the spent fuel in the spent fuel pools. According to the order of BNSA, from the beginning of December 2006 the licenses for operation of KNPP units 1 and 2 have been modified; this does not change the current status – operation of the units in mode „E‟ , but allows for dismantling of the systems and equipment, which are not important for safety and do not contain radioactive substances above the free release levels. The next step is obtaining a licence for Stage 1 decommissioning activities – Safe enclosure (SE) and dismantling in Turbine hall. The development of Decommissioning Safety Analysis Report (DSAR) is one of the documents needed for this license. The specific features of the units and decommitioning options are described

Síntese e caracterização de copolímeros de cadeia lateral derivados de acrilatos de 4,5-di-hidroisoxazol e do (--mentol

Directory of Open Access Journals (Sweden)

Joel A. Passo

2012-01-01

Full Text Available Five monomers 5-[4-(5-cyano-4,5-dihydroisoxazol-3-ylphenoxy]undecyl acrylate (7a; n-alkyl 3-{4-[5-(acryloyloxyundecyloxyphenyl]}-4,5-dihydroisoxazole-5-carboxylate (7b,c for n-butyl and n-hexyl, respectively; 3-{4-[5-(acryloyloxyundecyl oxyphenyl]}-4,5-dihydroisoxazole-5-carboxylic acid (7d and (1R,2S,5R-2-isopropyl-5-methylcyclohexyl acrylate (9 and the corresponding copolymers 10a-d,11 and homopolymers 12 from 7a and 13 from 9 were designed and synthesized. Except for acrylate 9 which is derived from (--menthol, all of the monomers belong to the series containing the isoxazoline ring linked to the acrylate unit by a flexible spacer chain of eleven methylene units. They presented low glass temperature and despite birefringence behavior, these copolymers showed no mesomorphic properties.

Retailing. Instructor's Guide Sheets and Instructor's Package, Modules R 1-45. Competency-Based Education.

Science.gov (United States)

Kentucky State Dept. of Education, Frankfort.

This package contains instructor's guide sheets and student task assignment sheets for Modules R 1-45 of the competency-based curriculum in retailing developed for use in secondary and postsecondary schools in Kentucky. Some of the topics covered in the modules include the following: retailing--past, present, and future; retailing occupations;…

A Design of 45-Degree Dual-Polarization Broadband Plane Station Antenna

Directory of Open Access Journals (Sweden)

Jianming Zhou

2015-01-01

Full Text Available A new broadband planar dual-polarization base station antenna is proposed, the antenna consists of two broadband plane coplanar base station antenna units, and so it has features of plane antenna. Two broadband plane station antenna units can, respectively, form double polarization in the direction. We analyzed the relative positions between the two antenna units and their effects on the performances of the antenna, especially for the influence of isolation. Broadband antenna has the characteristics of the broadband station antenna, and bandwidth is also guaranteed. The measured results show that the antenna can obtain 45% relative bandwidth, and 30 dB isolation degree also can be got, and the radiation performance is also good. Measurement results confirmed that the antenna gain can be guaranteed among 48% relative bandwidth, 15 dB of gain is got among bandwidth of 1.69–2.78 GHz, the isolation degree of different polarization method can reach 30 dB, and the measurement gain of two polarization methods of antenna both can reach 8.5 dBi.

Actual status of project Mochovce NPP units 3 and 4 completion

International Nuclear Information System (INIS)

Niznan, S.

2005-01-01

In this presentation author deals with actual status of project Mochovce NPP units 3 and 4 completion. Present state of Mochovce NPP, Units 3 and 4 enables real assumption to completion. It is expected that such supplier companies can be used which are experienced in field of nuclear projects. Based on budget of 2002, it seems that completion costs of 45 billions SKK are real. These figures were confirmed by study performed by TRACTEBEL in 2004. Based on experience from Bohunice NPP completion as well as from Mochovce NPP, Units 1 and 2 completion and if decision milestone and project start up deadlines will be observed according to modified preliminary schedule of Mochovce NPP Units 3 and 4 completion, it seems as real that Unit 3 will be completed till 06/2011 and Unit 4 - till 12/2011.

14 CFR 31.45 - Fuel cells.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel cells. 31.45 Section 31.45 Aeronautics... STANDARDS: MANNED FREE BALLOONS Design Construction § 31.45 Fuel cells. If fuel cells are used, the fuel cells, their attachments, and related supporting structure must be shown by tests to be capable of...

42 CFR 21.45 - Rating values.

Science.gov (United States)

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Rating values. 21.45 Section 21.45 Public Health... Appointment § 21.45 Rating values. The examination of every candidate for appointment to any grade in the... values for each part of the examination as are prescribed by the Surgeon General. No candidate who...

46 CFR 42.15-45 - Ventilators.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Ventilators. 42.15-45 Section 42.15-45 Shipping COAST... Conditions of Assignment of Freeboard § 42.15-45 Ventilators. (a) Ventilators in position 1 or 2 to spaces... any ventilator exceeds 351/2 inches in height it shall be specially supported. (b) Ventilators passing...

A multicenter study of plasma use in the United States.

Science.gov (United States)

Triulzi, Darrell; Gottschall, Jerome; Murphy, Edward; Wu, Yanyun; Ness, Paul; Kor, Daryl; Roubinian, Nareg; Fleischmann, Debra; Chowdhury, Dhuly; Brambilla, Donald

2015-06-01

Detailed information regarding plasma use in the United States is needed to identify opportunities for practice improvement and design of clinical trials of plasma therapy. Ten US hospitals collected detailed medical information from the electronic health records for 1 year (2010-2011) for all adult patients transfused with plasma. A total of 72,167 units of plasma were transfused in 19,596 doses to 9269 patients. The median dose of plasma was 2 units (interquartile range, 2-4; range 1-72); 15% of doses were 1 unit, and 45% were 2 units. When adjusted by patient body weight (kg), the median dose was 7.3 mL/kg (interquartile range, 5.5-12.0). The median pretransfusion international normalized ratio (INR) was 1.9 (25%-75% interquartile range, 1.6-2.6). A total of 22.5% of plasma transfusions were given to patients with an INR of less than 1.6 and 48.5% for an INR of 2.0 or more. The median posttransfusion INR was 1.6 (interquartile range, 1.4-2.0). Only 42% of plasma transfusions resulted in a posttransfusion INR of less than 1.6. Correction of INR increased as the plasma dose increased from 1 to 4 units (p plasma. The most common issue locations were general ward (38%) and intensive care unit (ICU; 42%). This large database describing plasma utilization in the United States provides evidence for both inadequate dosing and unnecessary transfusion. Measures to improve plasma transfusion practice and clinical trials should be directed at patients on medical and surgical wards and in the ICU where plasma is most commonly used. © 2014 AABB.

48 CFR 45.103 - General.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false General. 45.103 Section 45.103 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT... voluntary consensus standards (see FAR 11.101(b)) and industry-leading practices and standards to manage...

Attributes for NHDPlus Catchments (Version 1.1) for the Conterminous United States: Mean Annual R-factor, 1971-2000

Science.gov (United States)

Wieczorek, Michael; LaMotte, Andrew E.

2010-01-01

This data set represents the average annual R-factor, rainfall-runoff erosivity measure, compiled for every catchment of NHDPlus for the conterminous United States. The source data are from Christopher Daly of the Spatial Climate Analysis Service, Oregon State University, and George Taylor of the Oregon Climate Service, Oregon State University (2002), who developed spatially distributed estimates of R-factor for the period 1971-2000 for the conterminous United States. The NHDPlus Version 1.1 is an integrated suite of application-ready geospatial datasets that incorporates many of the best features of the National Hydrography Dataset (NHD) and the National Elevation Dataset (NED). The NHDPlus includes a stream network (based on the 1:100,00-scale NHD), improved networking, naming, and value-added attributes (VAAs). NHDPlus also includes elevation-derived catchments (drainage areas) produced using a drainage enforcement technique first widely used in New England, and thus referred to as "the New England Method." This technique involves "burning in" the 1:100,000-scale NHD and when available building "walls" using the National Watershed Boundary Dataset (WBD). The resulting modified digital elevation model (HydroDEM) is used to produce hydrologic derivatives that agree with the NHD and WBD. Over the past two years, an interdisciplinary team from the U.S. Geological Survey (USGS), and the U.S. Environmental Protection Agency (USEPA), and contractors, found that this method produces the best quality NHD catchments using an automated process (USEPA, 2007). The NHDPlus dataset is organized by 18 Production Units that cover the conterminous United States. The NHDPlus version 1.1 data are grouped by the U.S. Geologic Survey's Major River Basins (MRBs, Crawford and others, 2006). MRB1, covering the New England and Mid-Atlantic River basins, contains NHDPlus Production Units 1 and 2. MRB2, covering the South Atlantic-Gulf and Tennessee River basins, contains NHDPlus

46 CFR 45.131 - Ventilators.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Ventilators. 45.131 Section 45.131 Shipping COAST GUARD....131 Ventilators. (a) Ventilators passing through superstructures other than enclosed superstructures must have coamings of steel or equivalent material at the freeboard deck. (b) Ventilators in position 1...

Measurements of the neutron electric to magnetic form factor ratio GEn/GMn via the 2H(e→,e'n→)1H reaction to Q2=1.45 (GeV/c)2

International Nuclear Information System (INIS)

Plaster, B.; Semenov, A.Yu.; Semenova, I.A.; Aghalaryan, A.; Asaturyan, R.; Mkrtchyan, H.; Stepanyan, S.; Tadevosyan, V.; Crouse, E.; Finn, J.M.; Perdrisat, C.; Roche, J.; MacLachlan, G.; Opper, A.K.; Tajima, S.; Churchwell, S.; Howell, C.R.; Tireman, W.; Ahmidouch, A.; Anderson, B. D.

2006-01-01

We report values for the neutron electric to magnetic form factor ratio, G En /G Mn , deduced from measurements of the neutron's recoil polarization in the quasielastic 2 H(e→,e ' n→) 1 H reaction, at three Q 2 values of 0.45, 1.13, and 1.45 (GeV/c) 2 . The data at Q 2 =1.13 and 1.45 (GeV/c) 2 are the first direct experimental measurements of G En employing polarization degrees of freedom in the Q 2 >1 (GeV/c) 2 region and stand as the most precise determinations of G En for all values of Q 2

NPP Mochovce units 1 and 2 diagnostic systems

International Nuclear Information System (INIS)

Heidenreich, S.

1997-01-01

In this paper the diagnostic systems (leak detection monitoring, vibration monitoring, lose parts monitoring, fatigue monitoring) of NPP Mochovce units 1 and 2 are presented. All of the designed diagnostic systems are personal computer based systems

Second periodic safety review of Angra Nuclear Power Station, unit 1

Energy Technology Data Exchange (ETDEWEB)

Martins, Carlos F.O.; Crepaldi, Roberto; Freire, Enio M., E-mail: ottoncf@tecnatom.com.br, E-mail: emfreire46@gmail.com, E-mail: robcrepaldi@hotmail.com [Tecnatom do Brasil Engenharia e Servicos Ltda, Rio de Janeiro, RJ (Brazil); Campello, Sergio A., E-mail: sacampe@eletronuclear.gov.br [Eletrobras Termonuclear S.A. (ELETRONUCLEAR), Rio de Janeiro, RJ (Brazil)

2015-07-01

This paper describes the second Periodic Safety Review (PSR2-A1) of Angra Nuclear Power Station, Unit 1, prepared by Eletrobras Eletronuclear S.A. and Tecnatom do Brasil Engenharia e Servicos Ltda., during Jul.2013-Aug.2014, covering the period of 2004-2013. The site, in Angra dos Reis-RJ, Brazil, comprises: Unit 1, (640 MWe, Westinghouse PWR, operating), Unit 2 (1300 MWe, KWU/Areva, operating) and Unit 3 (1405 MWe, KWU/Areva, construction). The PSR2-A1 attends the Standards 1.26-Safety in Operation of Nuclear Power Plants, Brazilian Nuclear Regulatory Commission (CNEN), and IAEA.SSG.25-Periodic Safety Review of Nuclear Power Plants. Within 18 months after each 10 years operation, the operating organization shall perform a plant safety review, to investigate the evolution consequences of safety code and standards, regarding: Plant design; structure, systems and components behavior; equipment qualification; plant ageing management; deterministic and probabilistic safety analysis; risk analysis; safety performance; operating experience; organization and administration; procedures; human factors; emergency planning; radiation protection and environmental radiological impacts. The Review included 6 Areas and 14 Safety Parameters, covered by 33 Evaluations.After document evaluations and discussions with plant staff, it was generated one General and 33 Specific Guide Procedures, 33 Specific and one Final Report, including: Description, Strengths, Deficiencies, Areas for Improvement and Conclusions. An Action Plan was prepared by Electronuclear for the recommendations. It was concluded that the Unit was operated within safety standards and will attend its designed operational lifetime, including possible life extensions. The Final Report was submitted to CNEN, as one requisite for renewal of the Unit Permanent Operation License. (author)

Second periodic safety review of Angra Nuclear Power Station, unit 1

International Nuclear Information System (INIS)

Martins, Carlos F.O.; Crepaldi, Roberto; Freire, Enio M.; Campello, Sergio A.

2015-01-01

This paper describes the second Periodic Safety Review (PSR2-A1) of Angra Nuclear Power Station, Unit 1, prepared by Eletrobras Eletronuclear S.A. and Tecnatom do Brasil Engenharia e Servicos Ltda., during Jul.2013-Aug.2014, covering the period of 2004-2013. The site, in Angra dos Reis-RJ, Brazil, comprises: Unit 1, (640 MWe, Westinghouse PWR, operating), Unit 2 (1300 MWe, KWU/Areva, operating) and Unit 3 (1405 MWe, KWU/Areva, construction). The PSR2-A1 attends the Standards 1.26-Safety in Operation of Nuclear Power Plants, Brazilian Nuclear Regulatory Commission (CNEN), and IAEA.SSG.25-Periodic Safety Review of Nuclear Power Plants. Within 18 months after each 10 years operation, the operating organization shall perform a plant safety review, to investigate the evolution consequences of safety code and standards, regarding: Plant design; structure, systems and components behavior; equipment qualification; plant ageing management; deterministic and probabilistic safety analysis; risk analysis; safety performance; operating experience; organization and administration; procedures; human factors; emergency planning; radiation protection and environmental radiological impacts. The Review included 6 Areas and 14 Safety Parameters, covered by 33 Evaluations.After document evaluations and discussions with plant staff, it was generated one General and 33 Specific Guide Procedures, 33 Specific and one Final Report, including: Description, Strengths, Deficiencies, Areas for Improvement and Conclusions. An Action Plan was prepared by Electronuclear for the recommendations. It was concluded that the Unit was operated within safety standards and will attend its designed operational lifetime, including possible life extensions. The Final Report was submitted to CNEN, as one requisite for renewal of the Unit Permanent Operation License. (author)

Density functional theory design D-D-A type small molecule with 1.03 eV narrow band gap: effect of electron donor unit for organic photovoltaic solar cell

Science.gov (United States)

Sıdır, İsa

2017-10-01

Six new low-band-gap copolymers of donor-donor-acceptor (D-D-A) architecture have been designed using density functional theory and time-dependent density functional theory methods in order to use them in organic photovoltaic cell (OPVC). Phenanthro[3,4-d:9,10-d‧]bis([1,2,3]thiadiazole)-10,12-dicarbonitrile moiety has been used as an acceptor for all compounds. We insert benzo[1,2-b:4,5-b‧]dithiophene and N,N-diphenylbenzo[1,2-b:4,5-b‧]dithiophen-2-amine units as donor to complete designing of copolymers. In order to tuning the optical and electronic properties, we have modified the donor unit by substituted with amine, methoxyamine, N-methylenethiophen-2-amine, methoxy, alkoxy moieties. The band gap (Eg), HOMO and LUMO values and plots, open circuit voltage (VOC) as well as optical properties have been analysed for designed copolymers. The optimised copolymers exhibit low-band-gap lying in the range of 1.03-2.24 eV. DPTD-6 copolymer presents the optimal properties to be used as an active layer due to its low Eg (1.03 eV) and a moderate VOC (0.56 eV). Thus, OPVC based on this copolymer in bulk-heterojunction composites with [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) as an acceptor has been modelled. Eg and VOC values of composite material DPTD-6:PCBM are found as 1.32 and 0.65 eV, respectively. A model band diagram has been established for OPVC, simulating the energy transfer between active layers.

Control room habitability Analysis and Testing for Wolsong Unit 1

Energy Technology Data Exchange (ETDEWEB)

Lee, J. B. [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2013-05-15

In response to this recommendation, KHNP has established CRH program and performed tracer gas in leakage tests. These activities are described herein including the emergency ventilation system analysis, acceptance criteria calculation for the test and Control Room Envelope (CRE) discrimination, and the results of the tracer gas tests are presented. CRH analysis including unfiltered in leakage tests according to the methodology in ASTM E741 was performed for Wolsong Unit 1. The results show that the integrity of the control room of Wolsong Unit 1 is in good condition to maintain the reactor in a safe condition under accident conditions, which complies with the US NRC regulatory guides 1.78, 1.196 and 1.197.

Early evolutionary colocalization of the nuclear ribosomal 5S and 45S gene families in seed plants: evidence from the living fossil gymnosperm Ginkgo biloba.

Science.gov (United States)

Galián, J A; Rosato, M; Rosselló, J A

2012-06-01

In seed plants, the colocalization of the 5S loci within the intergenic spacer (IGS) of the nuclear 45S tandem units is restricted to the phylogenetically derived Asteraceae family. However, fluorescent in situ hybridization (FISH) colocalization of both multigene families has also been observed in other unrelated seed plant lineages. Previous work has identified colocalization of 45S and 5S loci in Ginkgo biloba using FISH, but these observations have not been confirmed recently by sequencing a 1.8 kb IGS. In this work, we report the presence of the 45S-5S linkage in G. biloba, suggesting that in seed plants the molecular events leading to the restructuring of the ribosomal loci are much older than estimated previously. We obtained a 6.0 kb IGS fragment showing structural features of functional sequences, and a single copy of the 5S gene was inserted in the same direction of transcription as the ribosomal RNA genes. We also obtained a 1.8 kb IGS that was a truncate variant of the 6.0 kb IGS lacking the 5S gene. Several lines of evidence strongly suggest that the 1.8 kb variants are pseudogenes that are present exclusively on the satellite chromosomes bearing the 45S-5S genes. The presence of ribosomal IGS pseudogenes best reconciles contradictory results concerning the presence or absence of the 45S-5S linkage in Ginkgo. Our finding that both ribosomal gene families have been unified to a single 45S-5S unit in Ginkgo indicates that an accurate reassessment of the organization of rDNA genes in basal seed plants is necessary.

The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema.

Science.gov (United States)

Tan, Li Hui; Bahmed, Karim; Lin, Chih-Ru; Marchetti, Nathaniel; Bolla, Sudhir; Criner, Gerard J; Kelsen, Steven; Madesh, Muniswamy; Kosmider, Beata

2018-02-23

Emphysema is characterized by irreversibly enlarged airspaces and destruction of alveolar walls. One of the factors contributing to this disease pathogenesis is an elevation in extracellular matrix (ECM) degradation in the lung. Alveolar type II (ATII) cells produce and secrete pulmonary surfactants and proliferate to restore the epithelium after damage. We isolated ATII cells from control non-smokers, smokers and patients with emphysema to determine the role of NFE2 (nuclear factor, erythroid-derived 2). NFE2 is a heterodimer composed of two subunits, a 45 kDa (p45 NFE2) and 18 kDa (p18 NFE2) polypeptides. Low expression of p45 NFE2 in patients with emphysema correlated with a high ECM degradation. Moreover, we found that NFE2 knockdown increased cell death induced by cigarette smoke extract. We also studied the cross talk between p45 NFE2 and DJ-1. DJ-1 protein is a redox-sensitive chaperone that protects cells from oxidative stress. We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis.

Environmental Control Plan for the 300-FF-1 Operable Unit Remedial Action

International Nuclear Information System (INIS)

Carlson, R.A.

2000-01-01

This environmental control plan is for the 300-FF-1 Operable Unit Remedial Action Project. The purpose of this plan is to identify environmental requirements for the 300-FF-1 operable unit Remedial Action/Waste Disposal Project

Cernavoda NPP Unit 1 - a plant of several generations

International Nuclear Information System (INIS)

Rotaru, I.; Metes, M.; Anghelescu, M.S.

2000-01-01

Cernavoda NPP Unit 1, the first nuclear power unit in Romania, has a long and tormented history. It represents a rather unique case in Eastern Europe. The project started well before 1989 (the construction phase lasted 17 years and generations were involved in its completion), but it is effectively based on western technology (Candu). Meanwhile, the national nuclear program underwent many changes, affecting the lives and careers of Romanian nuclear professionals. Finally, on December 2 nd 1996, the unit began its c ommercial operation , being operated at its nominal power rating of 706 MW e . It now provides a reliable source of electricity for Romanian economy, supplying to the national grid about 10% of the country's average annual demand. The paper reflects some aspects related to the shift of generations during the project's development, including the present stage. The operational performances achieved 'in service' by Cernavoda NPP Unit 1 up to the end of 1999 , are also presented. Reference to the electrical energy production, performance indicators, production costs, nuclear safety, radiation protection, radioactive wastes, nuclear fuel consumption and nuclear fuel performances are included. Comparisons are performed with similar indicators reported by other worldwide nuclear power plants, in order to assess our results. (authors)

27 CFR 5.45 - Application.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Application. 5.45 Section 5.45 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Standards of Fill for Bottled...

Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials.

Science.gov (United States)

Hacke, Werner; Lyden, Patrick; Emberson, Jonathan; Baigent, Colin; Blackwell, Lisa; Albers, Gregory; Bluhmki, Erich; Brott, Thomas; Cohen, Geoffrey; Davis, Stephen M; Donnan, Geoffrey A; Grotta, James C; Howard, George; Kaste, Markku; Koga, Masatoshi; von Kummer, Rüdiger; Lansberg, Maarten G; Lindley, Richard I; Olivot, Jean-Marc; Parsons, Mark; Sandercock, Peter Ag; Toni, Danilo; Toyoda, Kazunori; Wahlgren, Nils; Wardlaw, Joanna M; Whiteley, William N; Del Zoppo, Gregory; Lees, Kennedy R

2018-02-01

Background The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke differs between the Europe Union and United States. Aims We compared the effects of alteplase in cohorts defined by the current Europe Union or United States marketing approval labels, and by hypothetical revisions of the labels that would remove the Europe Union upper age limit or extend the United States treatment time window to 4.5 h. Methods We assessed outcomes in an individual-patient-data meta-analysis of eight randomized trials of intravenous alteplase (0.9 mg/kg) versus control for acute ischemic stroke. Outcomes included: excellent outcome (modified Rankin score 0-1) at 3-6 months, the distribution of modified Rankin score, symptomatic intracerebral hemorrhage, and 90-day mortality. Results Alteplase increased the odds of modified Rankin score 0-1 among 2449/6136 (40%) patients who met the current European Union label and 3491 (57%) patients who met the age-revised label (odds ratio 1.42, 95% CI 1.21-1.68 and 1.43, 1.23-1.65, respectively), but not in those outside the age-revised label (1.06, 0.90-1.26). By 90 days, there was no increased mortality in the current and age-revised cohorts (hazard ratios 0.98, 95% CI 0.76-1.25 and 1.01, 0.86-1.19, respectively) but mortality remained higher outside the age-revised label (1.19, 0.99-1.42). Similarly, alteplase increased the odds of modified Rankin score 0-1 among 1174/6136 (19%) patients who met the current US approval and 3326 (54%) who met a 4.5-h revised approval (odds ratio 1.55, 1.19-2.01 and 1.37, 1.17-1.59, respectively), but not for those outside the 4.5-h revised approval (1.14, 0.97-1.34). By 90 days, no increased mortality remained for the current and 4.5-h revised label cohorts (hazard ratios 0.99, 0.77-1.26 and 1.02, 0.87-1.20, respectively) but mortality remained higher outside the 4.5-h revised approval (1.17, 0.98-1.41). Conclusions An age-revised European Union label or 4.5

Stage-related behavioural problems in the 1-4 year old child: parental expectations in a child development unit referral group compared with a control group.

Science.gov (United States)

Ticehurst, R L; Henry, R L

1989-02-01

Behavioural problems in preschool (1-4 years) children are a common cause of referral to health services. Parents of children presenting to the child development unit with behavioural problems (n = 18) were compared with a control group (n = 45). A questionnaire was utilized to examine the parents' expectations of the children's behaviours. As might be expected, the parents of children presenting to the Unit rated their children as having more difficult behaviours. These parents had unrealistic expectations, particularly for the 'negative' behaviours (disobedience, temper tantrums, defiance and whinging). However, they were able to anticipate normal age-related difficulties in some problem areas (dawdling during mealtimes, masturbating, not sharing toys and being jealous of one's siblings). Counselling should address the issue of matching the expectations of parents with the individual rates of development of their children.

HUBUNGAN ANTARA STATUS GIZI DAN TINGKAT KEBUGARAN JASMANI DENGAN PRODUKTIVITAS KERJA PADA TENAGA KERJA WANITA UNIT SPINNING 1 BAGIAN WINDING PT. APAC INTI CORPORA BAWEN

Directory of Open Access Journals (Sweden)

Sri Rahayu Utami

2014-10-01

Full Text Available Tujuan penelitian ini untuk mengetahui hubungan antara status gizi dan tingkat kebugaran jasmani dengan produktivitas kerja pada tenaga kerja wanita unit Spinning 1 bagian Winding PT. Apac Inti Corpora Bawen. Jenis penelitian menggunakan explanatory research dengan pendekatan cross sectional. Populasi berjumlah 73 orang dengan sampel 45 orang. Pengambilan sampel menggunakan metode simple random sampling. Instrument yang digunakan adalah timbangan berat badan dan tinggi badan, bangku harvard, metronome, stopwatch dan lembar data produktivitas. Analisis data menggunakan uji Chi-Square dengan α = 0,05. Dan didapatkan hasil bahwa ada hubungan antara status gizi (p=0,005, tingkat kebugaran jasmani (p=0,001 dengan produktivitas kerja. Melalui penelitian ini diharapkan pekerja dapat mengkonsumsi makanan yang mengandung gizi seimbang ,serta melakukan olahraga untuk meningkatkan kebugaran jasmaninya. The purpose of this research to determine the relationship between nutritional status and level of physical fitness by working on labor productivity women Spinning unit 1 part Winding PT. Apac Inti Corpora Bawen. This research was explanatory research with cross sectional approach. Population was a 73 employees. And sample was 45 employees. Instrument was a weight scales and height, harvard bench, metronome, stopwatch and productivity data sheet. Was processed, using the Chi-Square statistic with α = 0.05. The results was a relationship between nutritional status (p = 0.005, level of physical fitness (p = 0.001 with labor productivity. This research will expect workers to consume foods that contain balanced nutrition and exercise to improve physical fitness.

Surry Power Station, Units 1 and 2. Semiannual operating report, January--June 1975

International Nuclear Information System (INIS)

1975-01-01

Net electric power generated by Unit 1 was 2,315,124 MWH(e) and Unit 2 generated 2,062,954 MWH(e) with Unit 1 generator on line for 3,157.8 hrs and Unit 2 on line for 2,881.2 hrs. Information is presented concerning power generation, shutdowns, corrective maintenance, chemistry and radiochemistry, occupational radiation exposure, release of radioactive materials, abnormal occurrences, and environmental monitoring. (FS)

Structures of three different neutral polysaccharides of Acinetobacter baumannii, NIPH190, NIPH201, and NIPH615, assigned to K30, K45, and K48 capsule types, respectively, based on capsule biosynthesis gene clusters.

Science.gov (United States)

Shashkov, Alexander S; Kenyon, Johanna J; Arbatsky, Nikolay P; Shneider, Mikhail M; Popova, Anastasiya V; Miroshnikov, Konstantin A; Volozhantsev, Nikolay V; Knirel, Yuriy A

2015-11-19

Neutral capsular polysaccharides (CPSs) were isolated from Acinetobacter baumannii NIPH190, NIPH201, and NIPH615. The CPSs were found to contain common monosaccharides only and to be branched with a side-chain 1→3-linked β-d-glucopyranose residue. Structures of the oligosaccharide repeat units (K units) of the CPSs were elucidated by 1D and 2D (1)H and (13)C NMR spectroscopy. Novel CPS biosynthesis gene clusters, designated KL30, KL45, and KL48, were found at the K locus in the genome sequences of NIPH190, NIPH201, and NIPH615, respectively. The genetic content of each gene cluster correlated with the structure of the CPS unit established, and therefore, the capsular types of the strains studied were designated as K30, K45, and K48, respectively. The initiating sugar of each K unit was predicted, and glycosyltransferases encoded by each gene cluster were assigned to the formation of the linkages between sugars in the corresponding K unit. Copyright © 2015 Elsevier Ltd. All rights reserved.

Preparation status for continuous operation of Kori unit 1 NPP in Korea

International Nuclear Information System (INIS)

Choi, C.H. . E-mail : chechee@khnp.co.kr

2005-01-01

Kori unit 1 Nuclear Power Plant is the first commercial operation plant in Korea. In Korea, the life extension of NPP beyond design lifetime reached practically application stage. Preparations status for continuous operation of Kori unit 1, Many researches have demonstrated that life extension beyond design lifetime is possible in terms of technology. This paper is to introduce and to share the continuous operation preparations status and schedule for Kori unit 1 License Renewal Process an additional every 10 years beyond the design life 30 years term. (author)

SPOKEN CUZCO QUECHUA, UNITS 1-6.

Science.gov (United States)

SOLA, DONALD F.; AND OTHERS

THE MATERIALS IN THIS VOLUME COMPRISE SIX UNITS WHICH PRESENT BASIC ASPECTS OF CUZCO QUECHUA PHONOLOGY, MORPHOLOGY, AND SYNTAX FOR THE BEGINNING STUDENT. THE SIX UNITS ARE DESIGNED FOR APPROXIMATELY 120 HOURS OF SUPERVISED CLASS WORK WITH OUTSIDE PREPARATION EXPECTED OF THE STUDENT. EACH UNIT CONSISTS OF A DIALOGUE TO BE MEMORIZED, A DIALOGUE…

Synthesis and Determination of pKa Values of Some New 3,4-Disubstituted-4,5-Dihydro-1H-1,2,4-triazol-5-one Derivatives in Non-aqueous Solvents

Directory of Open Access Journals (Sweden)

Mustafa Özdemir

2004-03-01

Full Text Available 3-Alkyl(Aryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2 reacted with 2-furoyl chloride and thiophene-2-carbonyl chloride to afford the corresponding 3- alkyl(aryl-4-(2-furoylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3 and 3-alkyl(aryl- 4-(2-thienylcarbonylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (4, respectively. The new compounds synthesized were characterized by using IR, 1H-NMR, 13C-NMR and UV spectral data together with elemental analysis. In addition, to investigate the effects of solvents and molecular structure upon acidity, compounds 3 and 4 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, N,N-dimethylformamide and acetonitrile. The half-neutralization potential values and the corresponding pKa values were determined for all cases.

76 FR 10215 - Airworthiness Directives; Learjet Inc. Model 45 Airplanes

Science.gov (United States)

2011-02-24

... the commenter's request. We have revised the language in the SUMMARY section and paragraph (e) of this... this AD. (1) Serial numbers 45-2001 through 45-2114 inclusive, 45-2116 through 45-2120 inclusive, 45-2122, 45-2125, and 45-2126. (2) Serial numbers 45-005 through 45-380 inclusive, 45-382 through 45-391...

27 CFR 45.45a - Notice for pipe tobacco.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for pipe tobacco. 45.45a Section 45.45a Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO REMOVAL OF TOBACCO PRODUCTS AND CIGARETTE PAPERS AND TUBES...

Feasibility study report for the 200-BP-1 operable unit

Energy Technology Data Exchange (ETDEWEB)

1993-06-01

This feasibility study examines a range of alternatives and provides recommendations for selecting a preferred alternative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965--1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area, groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-levels of contamination with cesium-137, radium-226, strontium-90, thorium-228, and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9{times}10{sup {minus}5}.

Feasibility study report for the 200-BP-1 operable unit

International Nuclear Information System (INIS)

1993-06-01

This feasibility study examines a range of alternatives and provides recommendations for selecting a preferred alternative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965--1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area, groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-levels of contamination with cesium-137, radium-226, strontium-90, thorium-228, and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9x10 -5

Feasibility study report for the 200-BP-1 operable unit

International Nuclear Information System (INIS)

1994-01-01

This feasibility study (FS) examines a range of alternatives and provides recommendations for selecting a preferred altemative for remediating contamination at the 200-BP-1 operable unit. The 200-BP-1 operable unit is located in the center of the Hanford Site along the northern boundary of the 200 East Area. The 241-BY Tank Farm is located immediately to the south of the operable unit. 200-BP-1 is a source operable unit with contaminated soils associated primarily with nine inactive cribs (known as the 216-B cribs). These cribs were used for disposal of low-level radioactive liquid waste from U Plant uranium recovery operations, and waste storage tank condensate from the adjacent 241-BY Tank Farm. The cribs used for disposal of U Plant waste were in operation from 1955--1965, and the cribs used for disposal of tank condensate were in operation from 1965-1975. In addition to the cribs, four unplanned releases of radioactive materials have occurred within the operable unit. Contaminated surface soils associated with the unplanned releases have been consolidated over the cribs and covered with clean soil to reduce contaminant migration and exposure. Discharge of wastes to the cribs has resulted in soil and groundwater contamination. The groundwater is being addressed as part of the 200 East Aggregate Area groundwater operable unit. Contaminated soils at the site can be categorized by the types of contaminants, their distribution in the soil column, and the risk posed by the various potential exposure pathways. Below the clean soil cover, the near surface soils contain low-:levels of contamination with cesium-137, radium-226, strontium-90, thorium-228 and uranium. The lifetime incremental cancer risk associated with these soils if they were exposed at the surface is 9 x 10 5

Limited field investigation report for the 100-DR-1 Operable Unit

International Nuclear Information System (INIS)

1994-06-01

This limited field investigation (LFI) report summarizes the data collection and analysis activities conducted during the 100-DR-1 Source Operable Unite LFI and the associated qualitative risk assessment (QRA), and makes recommendations on the continued candidacy of high-priority sites for interim remedial measures (IRM). The results and recommendations presented in this report are generally independent of future land use scenarios. The 100-DR-1 Operable Unit is one of four operable units associated with the 100 D/DR Area at the Hanford Site. The 100-DR-1 Operable Unit encompasses approximately 1.5 km 2 (0.59 mi 2 ) and is located immediately adjacent to the Columbia River shoreline. In general, it contains waste facilities associated with the original plant facilities constructed to support D Reactor facilities, as well as cooling water retention basin systems for both D and DR Reactors. The 100-DR-1 LFI began the investigative phase of the remedial investigation for a select number of high-priority sites. The LFI was performed to provide additional data needed to support selection, design and implementation of IRM, if needed. The LFI included data compilation, nonintrusive investigations, intrusive investigations, summarization of 100 Area aggregate studies, and data evaluation

Nosocomial bloodstream infection in a neonatal intensive care unit of a medical center: a three-year review.

Science.gov (United States)

Tseng, Ya-Chun; Chiu, Yu-Chiao; Wang, Jen-Hsien; Lin, Hsiao-Chuan; Lin, Hung-Chih; Su, Bai-Horng; Chiu, Hsiu-Hui

2002-09-01

Bloodstream infections are the most frequent nosocomial infections in neonatal intensive care units. This retrospective study surveyed the epidemiologic characteristics of nosocomial bloodstream infections which occurred in the neonatal intensive care unit from January 1, 1997 to December 31, 1999. The overall infection patient rate was 5.5% in the 3-year period, and the overall infection patient-day rate was 4.4 per 1000 patient-days. Low birth weight was a risk factor for bloodstream infections. The rate of infection for neonates with birth weight below 1000 g ranged from 36.6% to 45.8% (1997: 36.6%; 1998: 45.8% and 1999: 38.9%). The most common pathogens causing nosocomial bloodstream infection were: Staphylococcus aureus (18.5%) (with 92% oxacillin-resistant), Acinectobacter baumannii (16.3%), Klebsiella pneumoniae (11.9%), Escherichia coli (9.6%), and Pseudomonas aeruginosa (8.1%). The mortality due to nosocomial bloodstream infection was highest among gram-negative bacteria, especially with P. aeruginosa (45.5%). Therefore, surveillance of nosocomial bloodstream infection and successful strategies to decrease nosocomial bloodstream infection, such as infection control and optimal antibiotic use, are warranted.

Preparation, GIAO NMR Calculations and Acidic Properties of Some Novel 4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives with Their Antioxidant Activities

Directory of Open Access Journals (Sweden)

Havva Aksu

2008-01-01

Full Text Available Six novel 3-alkyl(aryl-4-(p-nitrobenzoylamino-4,5-dihydro-1H-1,2,4-triazol-5- ones (2a-f were synthesized by the reactions of 3-alkyl(aryl-4-amino-4,5-dihydro-1H- 1,2,4-triazol-5-ones (1a-f with p-nitrobenzoyl chloride and characterized by elemental analyses and IR, 1H-NMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as acetone, isopropyl alcohol, tert-butyl alcohol and N,Ndimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. Thus, the effects of solvents and molecular structure upon acidity were investigated. In addition, isotropic 1H and 13C nuclear magnetic shielding constants of compounds 2 were obtained by the gauge-including-atomic-orbital (GIAO method at the B3LYP density functional level. The geometry of each compound has been optimized using the 6-311G basis set. Theoretical values were compared to the experimental data. Furthermore, these new compounds and five recently reported 3-alkyl-4-(2- furoylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (3a-c,e,f were screened for their antioxidant activities.

30 CFR 45.4 - Independent contractor register.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Independent contractor register. 45.4 Section... ADMINISTRATIVE REQUIREMENTS INDEPENDENT CONTRACTORS § 45.4 Independent contractor register. (a) Each independent contractor shall provide the production-operator in writing the following information: (1) The independent...

Newman Unit 1 advanced solar repowering. Final report

Energy Technology Data Exchange (ETDEWEB)

None

1982-04-01

The five appendices give the selection process and system specification of the Newman Unit 1 solar repowering system, including the conceptual design drawings and diagrams; input data for the simulation program; and a review of the most important characteristics of the existing plant. (LEW)

Provision of bereavement care in neonatal units in the United Kingdom.

Science.gov (United States)

Robertson, Meredith J P; Aldridge, Anne; Curley, Anna E

2011-05-01

To establish what bereavement care services are available in neonatal units in the United Kingdom and to establish the availability to staff (doctors, nurses, and chaplains) of bereavement education, training, communication, and multicultural support. For families who lose a baby in the neonatal period, the support they receive from hospital staff can be pivotal in their ability to cope with their grief. Hospital staff are not always trained to provide this support. Limited evidence is available regarding hospital-based bereavement care in neonatology or its impact on outcome. Questionnaire survey of selected doctors, nurses, and chaplains in 200 neonatal units in the United Kingdom. We had responses from 100% of neonatal units surveyed. Of 600 individuals, 320 responded; 11% of doctors had never received any formal training in bereavement care, compared with 0.8% of nurses and 1.2% and chaplains. In addition, 31% of respondents thought the training they received was inadequate. Knowledge of grief theorists was poor. Up to 99% of units were helping parents create memories through photographs or handprints. Parents were uniformly given the chance to be with their baby at the time of death (99% overall). Siblings were encouraged to be present 71% of the time; 75% of respondents felt that information about the needs of different faith groups was available. Formal psychological support was offered to 45% of families after bereavement. Studies have shown that parents value clear communication, education about grieving, and demonstrated emotional support by staff. Our study has shown that there are deficiencies in staff training and education in this area. Educators must promote the inclusion of content on bereavement/end-of-life care. Additional education on cultural issues would be helpful. Managing the bereavement process well to minimize morbidity for families and healthcare providers is an important challenge for the future.

Extra-regulatory impact tests and analyses of the structural evaluation test unit

International Nuclear Information System (INIS)

Ludwigsen, J.S.; Ammerman, D.J.

1995-01-01

The structural evaluation test unit is roughly equivalent to a 1/3 scale model of a high level waste rail cask. The test unit was designed to just meet the requirements of NRC Regulatory Guide 7.6 when subjected to a 9 m (30 ft) free drop resulting in an impact velocity of 13.4 m/s (30 mph) onto an unyielding target in the end-on orientation. The test unit was then subjected to impacts with higher velocities to determine the amount of built-in conservatism in this design approach. Test impacts of 13.4, 20.1 and 26.8 m/s (30, 45, and 60 mph) were performed. This paper will describe the design, testing, and comparison of measured strains and deformations to the equivalent analytical predictions

Comparison of Readmission Rates After Acute Myocardial Infarction in 3 Patient Age Groups (18 to 44, 45 to 64, and ≥65 Years) in the United States.

Science.gov (United States)

Khera, Rohan; Jain, Snigdha; Pandey, Ambarish; Agusala, Vijay; Kumbhani, Dharam J; Das, Sandeep R; Berry, Jarett D; de Lemos, James A; Girotra, Saket

2017-11-15

Postacute myocardial infarction (AMI) readmissions are common among Medicare beneficiaries (≥65 years) and are associated with significant resource utilization. However, patterns of AMI readmissions for younger age groups in the United States are not known. In the Nationwide Readmissions Database, a nationally representative all-payer database of inpatient hospitalizations, we identified 212,171 index AMI hospitalizations in January to November 2013, weighted to represent 478,247 hospitalizations nationally (mean age 66.9 years, 38% women, 29% low income). This included 26,516 cases in the 18 to 44 age group, 183,703 in the 45 to 64 age group, and 268,027 in the ≥65 age group. The overall 30-day readmission rate was 14.5% and varied across age groups (9.7% [18 to 44], 11.2% [45 to 64], and 17.3% [≥65]). The cumulative cost of 30-day readmissions was $1.1 billion, of which $365 million was spent on those age. In multivariable hierarchical models, the risk of readmission was higher in women and in low-income patients, but the effect varied by age (p value for age-gender and age-income interactions age groups. Further, patients in all age groups continue to have a high hospitalization burden beyond the typical 30-day readmission period, with an overall 24% post-AMI 90-day readmission rate. In conclusion, readmissions in young and middle-aged AMI survivors pose a substantial burden on patients and on U.S. health-care resources. Women and low-income patients with AMI, particularly those in younger age groups, are more frequently readmitted, and readmissions continue to burden the health-care system beyond the typical 30-day window. Future investigations would need to be targeted toward a better understanding and improvement of the rehospitalization burden for vulnerable patient groups. Copyright © 2017 Elsevier Inc. All rights reserved.

Levels in 45K and 46K excited by the β decay of 45Ar and 46Ar

International Nuclear Information System (INIS)

Huck, A.; Klotz, G.; Knipper, A.; Miehe, C.; Walter, G.

1979-01-01

The nuclides 45 Ar and 46 Ar have been produced by spallation reactions on vanadium targets at Esub(p)=600MeV. The subsequent decays to 45 K and 46 K states have been studied. An intensity of 98.6+-0.6% was measured for the β transition of the 1.94MeV state in 46 K. A decay scheme involving 13 β branches has been established for 45 Ar, and the corresponding log values have been deduced. Eleven states are reported for the first time in the decay scheme of 45 Ar 1.42, 1.47, 1.72, 2.52, 2.57, 2.75, 3.31, 3.99, 4.04, 4.36 and 4.57MeV. From the lifetime, tau=4.6+-0.6ns, deduced from γ-γ delayed coincidences, the angular momentum of the 1081keV level has been established as (7/2) - on the basis of the transition strength of its γ decay. A survey on the 1fsub(7/2)→1dsub(3/2)M2 transition in odd K nuclei is presented and the observed hindrance factors are discussed

Where does distance matter? Distance to the closest maternity unit and risk of foetal and neonatal mortality in France.

Science.gov (United States)

Pilkington, Hugo; Blondel, Béatrice; Drewniak, Nicolas; Zeitlin, Jennifer

2014-12-01

The number of maternity units has declined in France, raising concerns about the possible impact of increasing travel distances on perinatal health outcomes. We investigated impact of distance to closest maternity unit on perinatal mortality. Data from the French National Vital Statistics Registry were used to construct foetal and neonatal mortality rates over 2001-08 by distance from mother's municipality of residence and the closest municipality with a maternity unit. Data from French neonatal mortality certificates were used to compute neonatal death rates after out-of-hospital birth. Relative risks by distance were estimated, adjusting for individual and municipal-level characteristics. Seven percent of births occurred to women residing at ≥30 km from a maternity unit and 1% at ≥45 km. Foetal and neonatal mortality rates were highest for women living at maternity unit. For foetal mortality, rates increased at ≥45 km compared with 5-45 km. In adjusted models, long distance to a maternity unit had no impact on overall mortality but women living closer to a maternity unit had a higher risk of neonatal mortality. Neonatal deaths associated with out-of-hospital birth were rare but more frequent at longer distances. At the municipal-level, higher percentages of unemployment and foreign-born residents were associated with increased mortality. Overall mortality was not associated with living far from a maternity unit. Mortality was elevated in municipalities with social risk factors and located closest to a maternity unit, reflecting the location of maternity units in deprived areas with risk factors for poor outcome. © The Author 2014. Published by Oxford University Press on behalf of the European Public Health Association.

Planning for decommissioning of Ignalina Nuclear Power Plant Unit-1

International Nuclear Information System (INIS)

Poskas, P.; Poskas, R.; Zujus, R.

2002-01-01

In accordance to Ignalina NPP Unit 1 Closure Law, the Government of Lithuania approved the Ignalina NPP Unit 1 Decommissioning Program until 2005. For enforcement of this program, the plan of measures for implementation of the program was prepared and approved by the Minister of Economy. The plan consists of two parts, namely technical- environmental and social-economic. Technical-environmental measures are mostly oriented to the safe management of spent nuclear fuel and operational radioactive waste stored at the plant and preparation of licensing documents for Unit 1 decommissioning. Social-economic measures are oriented to mitigate the negative social and economic impact on Lithuania, inhabitants of the region, and, particularly, on the staff of Ignalina NPP by means of creating favorable conditions for a balanced social and economic development of the region. In this paper analysis of planned radioactive waste management technologies, licensing documents for decommissioning, other technical-environmental and also social-economic measures is presented. Specific conditions in Lithuania important for defining the decommissioning strategy are highlighted. (author)

5-Methyl-4-oxo-4,6-dihydro-3H-pyridazino[4,5-b]carbazole-1-carbonitrile

Directory of Open Access Journals (Sweden)

Norbert Haider

2010-02-01

Full Text Available The title compound was prepared in excellent yield from 5-methyl-4-oxo-4,6-dihydro-3H-pyridazino[4,5-b]carbazole-1-carbaldehyde by treatment with hydroxylamine hydrochloride in formic acid without isolation of the intermediate oxime.

Evaluation of River Bend Station Unit 1 Technical Specifications

International Nuclear Information System (INIS)

Baxter, D.E.; Bruske, S.J.

1985-08-01

This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the River Bend Station Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the requirements of the Final Safety Analysis Report (FSAR) as amended, and the requirements of the Safety Evaluation Report (SER) as supplemented. A comparative audit of the FSAR as amended, and the SER as supplemented was performed with the River Bend T/S. Several discrepancies were identified and subsequently resolved through discussions with the cognizant NRC reviewer, NRC staff reviewers and/or utility representatives. The River Bend Station Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR and SER

Four years Re-Use of low burned fuel assemblies from units 1 and 2 in core loadings of units 3 and 4 WWER-440 at Kozloduy NPP

International Nuclear Information System (INIS)

Stoyanova, I.; Antov, A.; Spasova, V.

2006-01-01

At the end of 2002 units 1 and 2 of Kozloduy NPP were shutdown before their design life time which left a large number of assemblies yet with a significant energy resources. A decision to load these assemblies into the cores of Units 3 and 4 during the next 4 cycles has been taken. In 2003, 43 assemblies from Unit 1 cycle 23 rd and 55 assemblies from Unit 2 cycle 24 th are loaded in the cores of units 3 and 4 respectively. In 2004, new 49 assemblies from Unit 1 cycle 23rd and new 55 assemblies from Unit 2 cycle 24th are loaded in the cores of units 3 and 4 respectively. In 2005, the next new 25 assemblies from Unit 1 cycle 23 rd and 66 assemblies from Unit 2 cycle 24th are loaded in the cores of units 3 and 4 respectively. In 2006, the next new 54 assemblies from Unit 1 cycle 23 rd and 52 assemblies from Unit 2 cycle 24 th + 2 assemblies from Unit 3 cycle 19th are loaded in the cores of Units 3 and 4 respectively. The SPPSHB computer code system is used for development and safety assessment of the fuel loading patterns of Units 3 and 4 at Kozloduy NPP with low burned assemblies from units 1 and 2 (Authors)

Statement to the 34th session of the general conference of the International Atomic Energy Agency, 17 September 1990. Statement to the 45th session of the United Nations general assembly, 23 October 1990

International Nuclear Information System (INIS)

Blix, H.

1991-01-01

The document contains the following two statements of Hans Blix, Director General of the IAEA: Statement to the 34th Session of the General Conference of the International Atomic Energy Agency, 17 September 1990; Statement to the 45th Session of the United Nations General Assembly, 23 October 1990. A separate abstract was prepared for each of these statements

[Effect of 45 degree angle semirecumbent position on ventilator-associated pneumonia in mechanical ventilated patients: a meta-analysis].

Science.gov (United States)

Leng, Yu-xin; Song, Ya-han; Yao, Zhi-yuan; Zhu, Xi

2012-10-01

To systemically analyze the effect of 45 degree angle semirecumbent position on the incidence of ventilator-associated pneumonia (VAP) and other outcomes in mechanical ventilated patients, and to evaluate whether 45 degree angle semirecumbent position is superior to 25 degree angle-30 degree angle head of bed (HOB). The randomized controlled trials (RCTs) comparing the effect of different HOB on the outcomes of mechanical ventilated patients were searched (from 1st January 1990 to 20th July 2012) from five databases including the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, China Knowledge Resource Integrated Database (CNKI), and Wanfang Database. Meta analysis was conducted using RevMan 5.0 software. Data extracted from five RCTs with a total of 427 patients were analyzed. The risks of developing clinically diagnosed VAP were significantly lower among the patients in semirecumbent 45 degree angle position compared to the patients in lower position [15.96% (34/213) vs. 26.64% (57/214), relative risk (RR)=0.57, 95% confidence interval (95%CI) 0.39 to 0.83, P=0.003], while no significant differences were detected between the two groups regarding the mortality rate [27.04% (53/196) vs. 28.22% (57/202), RR=0.93, 95%CI 0.68 to 1.27, P=0.66], the length of intensive care unit (ICU) stay [weighted mean difference (WMD)=-0.45, 95%CI -1.08 to 0.18, P=0.16] and the percentage of antibiotics treatment [71.11% (32/45) vs. 60.87% (28/46), RR=1.14, 95%CI 0.85 to 1.53, P=0.37]. Two of the five trials (91 patients) were included in the sub-analysis between 45 degree angle group (45 patients) and 25 degree angle-30 degree angle group (46 patients). The results showed that comparing with 25 degree angle-30 degree angle, 45 degree angle semirecumbent position had no significance in improving patients' clinical outcomes. This study proved that the clinically preferred semirecumbent 45 degree angle position did have effect in reducing the incidence of VAP

Economic evaluation of Kori and Wolsong Unit 1 plant life extension

International Nuclear Information System (INIS)

Song, T. H.; Jeong, I. S.

2002-01-01

24 years have been passed since Kori Unit 1 began its commercial operation, and 19 years have been passed since Wolsong Unit 1 began its commercial operation. As the end point of design life become closer, plant life extension and periodic safety assessment is paid more and more attention to by the utility company. In this paper, the methodologies and results of plant lifetime management economic evaluations of both units have been presented in comparison with Korean standard nuclear power plant 10, 20 and 30 year life extension cases respectively. In addition to that, sensitivity analysis and break even point analysis results are presented with the variables of capacity factor, operation and maintenance cost, and discount rate

Antitumor potential of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles in human bladder cancer cells.

Science.gov (United States)

Tessmann, Josiane Weber; Buss, Julieti; Begnini, Karine Rech; Berneira, Lucas Moraes; Paula, Favero Reisdorfer; de Pereira, Claudio Martin Pereira; Collares, Tiago; Seixas, Fabiana Kömmling

2017-10-01

Bladder cancer is a genitourinary malignant disease common worldwide. Current chemotherapy is often limited mainly due to toxicity and drug resistance. Thus, there is a continued need to discover new therapies. Recently evidences shows that pyrazoline derivatives are promising antitumor agents in many types of cancers, but there are no studies with bladder cancer. In order to find potent and novel chemotherapy drugs for bladder cancer, a series of pyrazoline derivatives 2a-2d were tested for their antitumor activity in two human bladder cancer cell lines 5647 and T24. The MTT assay showed that the compounds 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole (2a) and 1-thiocarbamoyl-5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole (2c) decrease the cell viability of 5637 cells. Molecular modeling indicated that these compounds had a good oral bioavailability and low toxicities. Clonogenic assay and flow cytometric analysis were used to assess colony formation, apoptosis induction and cell cycle distribution. Overall, our results suggest that pyrazoline 2a and 2c, with the substituents hydrogen and chlorine respectively, may decrease cell viability and colony formation of bladder cancer 5637 cell line by inhibition of cell cycle progression, and for pyrazoline 2a, by induction of apoptosis. As indicated by the physicochemical properties of these compounds, the steric factor influences the activity. Therefore, these pyrazoline derivatives can be considered promising anticancer agents for the treatment of bladder cancer. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Unit 1b: A General Approach to the Teaching of Architecture

DEFF Research Database (Denmark)

Toft, Anne Elisabeth

2011-01-01

The chapter presents the overall academic aims of the teaching at Unit 1b and how these were implemented in the curriculum for 2009/2010. The section includes considerations about learning targets, method, discourse, pedagogy and didactics.......The chapter presents the overall academic aims of the teaching at Unit 1b and how these were implemented in the curriculum for 2009/2010. The section includes considerations about learning targets, method, discourse, pedagogy and didactics....

Three years re-use of low burned fuel assemblies from units 1 and 2 in core loading of units 3 and 4 WWER-440 at Kozloduy NPP

International Nuclear Information System (INIS)

Stoyanova, I.; Antov, A.; Spasova, V.

2006-01-01

At the end of 2002 Units 1 and 2 of Kozloduy NPP were shutdown before the end of their designed lifetime. This left a large number of assemblies yet with a significant energy resource. In 2003, 43 assemblies from Unit 1 and 55 assemblies from Unit 2 are loaded in the cores of Units 3 and 4 respectively. In 2004, new 49 assemblies from Unit 1 and new 55 assemblies from Unit 2 are loaded in the cores of Units 3 and 4 respectively. In 2005, the next new 25 assemblies from Unit 1 and 66 assemblies from Unit 2 are loaded in the cores of Units 3 and 4 respectively. The realized core loadings of Units 3 and 4 are illustrated. The large number of low burned assemblies after the shut down of Units 1 and 2 and their utilization during 4 consecutive cycles in the cores of Units 3 and 4 both do not permit to obtain in the last 3 cycles the typical mean burn up 35-36 MWd/kg U of 3.6% discharged assemblies

N,N,N,N′,N′,N′-Hexakis(2-hydroxyethylbutane-1,4-diaminium bis(2-sulfanylidene-1,3-dithiole-4,5-dithiolato-κ2S4,S5zincate

Directory of Open Access Journals (Sweden)

Xiulan Zhang

2013-07-01

Full Text Available In the asymmetric unit of the title compound, (C16H38N2O6[Zn(C3S52], two independent cations lie across inversion centers. In one of the cations, the three symmetry-unique O—H groups are disordered over two sets of sites with refined occupancy ratios of 0.701 (9:0.299 (9, 0.671 (8:0.329 (8 and 0.566 (7:0.434 (7. In the anion, the ZnII ion is coordinated in a distorted tetrahedral environment by four S atoms of two chelating 1,3-dithiole-2-thione-4,5-dithiolato ligands. The dihedral angle between the mean planes [maximun deviations = 0.022 (3 and 0.0656 (6 Å] of the two ligands is 87.76 (3°. An intamolecular O—H...O hydrogen bond occurs in the disordered cation. In the crystal, O—H...O and O—H...S hydrogen bonds link the components into a two-dimensional network parallel to (0-11.

RCRA facility investigation report for the 200-PO-1 operable unit. Revision 1

International Nuclear Information System (INIS)

1997-05-01

This Resource Conservation and Recovery Act (RCRA) Facility Investigation (RFI) report is prepared in support of the RFI/corrective measures study process for the 200-PO-1 Groundwater Operable Unit in the 200 East Area of the Hanford Site. This report summarizes existing information on this operable unit presented in the 200 East and PUREX Aggregate Area Management Study Reports, contaminant specific studies, available modeling data, and groundwater monitoring data summary reports. Existing contaminant data are screened against current regulatory limits to determine contaminants of potential concern (COPC). Each identified COPC is evaluated using well-specific and plume trend analyses

Reactor pressure vessel integrity of Genkai Unit 1

International Nuclear Information System (INIS)

Nakamuta, Y.; Nozaki, G.; Saruwatari, T.; Watanabe, S.; Yamashita, Y.

2015-01-01

The structural integrity of reactor pressure vessels (RPVs) of commercial nuclear power plants in Japan has to be confirmed for the continuing operation according to the Japanese technical standards, JEAC4206-2007 and JEAC4201-2007, which specify the procedures to evaluate the structural integrity of RPVs and the embrittlement of RPV materials, respectively. The structural integrity analysis of Genkai Unit 1 RPV was performed based on the 4. surveillance data. Even though the ΔRT(NDT) obtained for the base metal was larger than the prediction of the current embrittlement correlation method of JEAC4201-2007, the structural integrity of the RPV during PTS event was confirmed with a sufficient margin. The reason of the large ΔRT(NDT) in the base metal was investigated thoroughly in terms of the microstructural changes caused by the neutron irradiation. The study showed that the microstructural changes are all as expected for this class of material, no grain boundary fracture occurred, the material is homogeneous in terms of chemical composition, and the chemical compositions which are important for the evaluation of embrittlement are correct. All these results suggested room for improvement of the current embrittlement correlation method in JEAC4201-2007. Using Genkai Unit 1 data as well as other recent surveillance data, the embrittlement correlation method has been modified so that the recent high fluence data can be predicted with higher accuracy, and was issued as JEAC4201-2007, 2013 addendum. It has been demonstrated that the RPV materials of the Genkai Unit 1 meet the requirements of JEAC4206-2007 and can be used for the continuing safe operation up to 60 years

Knowledge, attitudes, and practices of nonpharmaceutical interventions following school dismissals during the 2009 Influenza A H1N1 pandemic in Michigan, United States.

Directory of Open Access Journals (Sweden)

Jianrong Shi

Full Text Available BACKGROUND: Many schools throughout the United States reported an increase in dismissals due to the 2009 influenza A H1N1 pandemic (pH1N1. During the fall months of 2009, more than 567 school dismissals were reported from the state of Michigan. In December 2009, the Michigan Department of Community Health, in collaboration with the United States Centers for Disease Control and Prevention, conducted a survey to describe the knowledge, attitudes, and practices (KAPs of households with school-aged children and classroom teachers regarding the recommended use of nonpharmaceutical interventions (NPIs to slow the spread of influenza. METHODS: A random sample of eight elementary schools (kindergarten through 5th grade was selected from each of the eight public health preparedness regions in the state. Within each selected school, a single classroom was randomly identified from each grade (K-5, and household caregivers of the classroom students and their respective teachers were asked to participate in the survey. RESULTS: In total, 26% (2,188/8,280 of household caregivers and 45% (163/360 of teachers from 48 schools (of the 64 sampled responded to the survey. Of the 48 participating schools, 27% (13 experienced a school dismissal during the 2009 fall term. Eighty-seven percent (1,806/2,082 of caregivers and 80% (122/152 of teachers thought that the 2009 influenza A H1N1 pandemic was severe, and >90% of both groups indicated that they told their children/students to use NPIs, such as washing hands more often and covering coughs with tissues, to prevent infection with influenza. CONCLUSIONS: Knowledge and instruction on the use of NPIs appeared to be high among household caregivers and teachers responding to the survey. Nevertheless, public health officials should continue to explain the public health rationale for NPIs to reduce pandemic influenza. Ensuring this information is communicated to household caregivers and teachers through trusted sources is

45 CFR 2521.45 - What are the limitations on the Federal government's share of program costs?

Science.gov (United States)

2010-10-01

...) Your share of member support costs must be non-Federal cash. (4) The Corporation's share of health care... administration costs. (1) You may provide your share of program operating costs with cash, including other...'s share of program costs? 2521.45 Section 2521.45 Public Welfare Regulations Relating to Public...

Occurrence of C35-C45 polyprenols in filamentous and unicellular cyanobacteria

NARCIS (Netherlands)

Bauersachs, T.; Schouten, S.; Compaoré, J.; Stal, L.J.; Sinninghe Damsté, J.S.

2010-01-01

Polyprenols, regular (head-to-tail) isoprenoid alcohols with 7-9 prenyl units, were tentatively identified in several cultivated cyanobacteria Heptaprenol (C35), octaprenol (C40) and a suite of nonaprenols (C45) were present in unicellular and filamentous non-heterocystous cyanobacteria, while they

75 FR 36700 - Exelon Generation Company, LLC; Three Mile Island Nuclear Station, Unit 1; Environmental...

Science.gov (United States)

2010-06-28

...; Three Mile Island Nuclear Station, Unit 1; Environmental Assessment and Finding of No Significant Impact... Company, LLC (the licensee), for operation of Three Mile Island Nuclear Station, Unit 1 (TMI-1), located... Three Mile Island Nuclear Station, Units 1 and 2, NUREG-0552, dated December 1972, and Generic...

Synthesis and Cytotoxic Evaluation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones

Directory of Open Access Journals (Sweden)

INGRID C. CHIPOLINE

2018-02-01

Full Text Available ABSTRACT The 1,2-naphthoquinone compound was previously considered active against solid tumors. Moreover, glycosidase inhibitors such as 1,2,3-1H triazoles has been pointed out as efficient compounds in anticancer activity studies. Thus, a series of eleven 1,2-naphthoquinones tethered in C2 to 1,2,3-1H-triazoles 9a-k were designed, synthesized and their cytotoxic activity evaluated using HCT-116 (colon adenocarcinoma, MCF-7 (breast adenocarcinoma and RPE (human nontumor cell line from retinal epithelium. The chemical synthesis was performed from C-3 allylation of lawsone followed by iodocyclization with subsequent nucleophilic displacement with sodium azide and, finally, the 1,3-dipolar cycloaddition catalyzed by Cu(I with terminal alkynes led to the formation of 1H-1,2,3-Triazol-1-ylmethyl-2,3-dihydronaphtho[1,2-b]furan-4,5-diones in good yields. Compounds containing aromatic group linked to 1,2,3-triazole ring (9c, 9d, 9e, 9i presented superior cytotoxic activity against cancer cell lines with IC50 in the range of 0.74 to 4.4 µM indicating that the presence of aromatic rings substituents in the 1,2,3-1H-triazole moiety is probably responsible for the improved cytotoxic activity.

Hydrolytically stable titanium-45

DEFF Research Database (Denmark)

Severin, Gregory; Fonslet, Jesper; Zhuravlev, Fedor

2014-01-01

metal-based chemotherapeutics such as cisplatin. The aim of our work has been to produce the radioactive analogue of one of these Ti(IV)-salan compounds, Ti-salan-dipic [2], which has hydro-lytic stability on the order of weeks. Not only will this allow us to shed some light on the still un...... the physical characteristics are extremely desirable: 45Ti has a 3 hour half-life, a positron branching ratio of 85 %, a low Eβmax of 1.04 MeV, and negligible secondary gamma emission. In terms of isotope production, 45Ti is transmuted from naturally mono-isotopic 45Sc by low energy proton irradiation...... to a water-cooled silver plate. The activated foil was dissolved in 4M HCl, dried under argon at 120 oC, and taken back up in 12M HCl. Here, four (i-iv below) different approaches to removing the Ti from the Sc and labeling were taken with varying success. Briefly: i. 45Ti was separated on hydroxamate resin...

30 CFR 7.45 - Critical characteristics

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Critical characteristics 7.45 Section 7.45 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... characteristics The following critical characteristics shall be inspected or tested on each battery assembly to...

Corrective Action Decision Document/Closure Report for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada National Security Site, Nevada with ROTC 1 and 2, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Matthews, Patrick

2011-07-01

Corrective Action Unit 374 comprises five corrective action sites (CASs): • 18-22-05, Drum • 18-22-06, Drums (20) • 18-22-08, Drum • 18-23-01, Danny Boy Contamination Area • 20-45-03, U-20u Crater (Schooner) The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 374 based on the implementation of corrective actions. The corrective action of closure in place with administrative controls was implemented at CASs 18-23-01 and 20-45-03, and a corrective action of removing potential source material (PSM) was conducted at CAS 20-45-03. The other CASs require no further action; however, best management practices of removing PSM and drums at CAS 18-22-06, and removing drums at CAS 18-22-08 were performed. Corrective action investigation (CAI) activities were performed from May 4 through October 6, 2010, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 374: Area 20 Schooner Unit Crater, Nevada Test Site, Nevada. The approach for the CAI was divided into two facets: investigating the primary release of radionuclides and investigating other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 374 dataset of investigation results was evaluated based on the data quality indicator parameters. This evaluation demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Analytes detected during the CAI were evaluated against final action levels (FALs) established in this document. Radiological doses exceeding the FAL of 25 millirem per year were found to be present in the surface soil that was sampled. It is assumed that radionuclide levels present in subsurface media within the craters and ejecta fields (default contamination boundaries) at the Danny Boy and

45 CFR 1105.1 - Cross-reference to employee ethical conduct standards and financial disclosure and financial...

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Cross-reference to employee ethical conduct... STANDARDS OF CONDUCT FOR EMPLOYEES § 1105.1 Cross-reference to employee ethical conduct standards and... ethical conduct at 5 CFR part 2635; the executive branch employees responsibilities and conduct...

28 CFR 0.1 - Organizational units.

Science.gov (United States)

2010-07-01

... Legal Policy. Office of Public Affairs. Office of the Pardon Attorney. Office of Special Counsel for Immigration Related Unfair Employment Practices. Community Relations Service. Executive Office for Immigration Review. Executive Office for United States Attorneys. Executive Office for United States Trustees...

North Anna Power Station - Unit 1: Overview of steam generator replacement project activities

International Nuclear Information System (INIS)

Gettler, M.W.; Bayer, R.K.; Lippard, D.W.

1993-01-01

The original steam generators at Virginia Electric and Power Company's (Virginia Power) North Anna Power Station (NAPS) Unit 1 have experienced corrosion-related degradation that require periodic inspection and plugging of steam generator tubes to ensure their continued safe and reliable operation. Despite improvements in secondary water chemistry, continued tube degradation in the steam generators necessitated the removal from service of approximately 20.3 percent of the tubes by plugging, (18.6, 17.3, and 25.1 for steam generators A, B, and C, respectively). Additionally, the unit power was limited to 95 % during, its last cycle of operation. Projections of industry and Virginia Power experience indicated the possibility of mid-cycle inspections and reductions in unit power. Therefore, economic considerations led to the decision to repair the steam generators (i.e., replace the steam generator lower assemblies). Three new Model 51F Steam Generator lower assembly units were ordered from Westinghouse. Virginia Power contracted Bechtel Power Corporation to provide the engineering and construction support to repair the Unit 1 steam generators. On January 4, 1993, after an extended coastdown period, North Anna Unit 1 was brought off-line and the 110 day (breaker-to-breaker) Steam Generator Replacement Project (SGRP) outage began. As of this paper, the outage is still in progress

Crystal structure of 2-(thiophen-2-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl) ethenyl]benzamide: N,N-dimethylformamide (1 : 1)

Energy Technology Data Exchange (ETDEWEB)

Sharma, P. [University of Jammu, X-ray Crystallography Laboratory, Department of Physics (India); Subbulakshmi, K. N.; Narayana, B. [Mangalore University, Department of Chemistry (India); Sarojini, B. K. [Mangalore University, Industrial Chemistry Division, Department of Studies in Chemistry (India); Kant, R., E-mail: rkant.ju@gmail.com [University of Jammu, X-ray Crystallography Laboratory, Department of Physics (India)

2016-03-15

The title compound, 2-(thiophen-2-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethenyl] benzamide:N,N-dimethylformamide (1: 1), (C{sub 15}H{sub 11}N{sub 3}O{sub 2}S{sub 2} · C{sub 3}H{sub 7}NO), was synthesized, and its structure was established by spectral analysis and X-ray diffraction studies. The compound crystallizes in the monoclinic space group P2{sub 1}/n with a = 10.8714(7), b = 9.0497(5), c = 19.8347(13) Å, β = 91.093(5)°, Z = 4. The crystal structure is stabilized by N–H···S, C–H···O and N–H···O hydrogen bonds. The π···π interactions are also observed between the rings.

Top level risk study for units 1 to 4 at NPP Kozloduy

International Nuclear Information System (INIS)

Shishkova, I.

1997-01-01

The first Top Level Study of NPP Kozloduy Units 1/4 was started in 1991 and completed in March 1992 by BEQE. The Primary objective of the project was to provide in a short term a tool for quantified comparison of the relative risk benefits that various design or operational modifications would have if implemented on NPP Kozloduy Units 1/4. This original version of the Study was reviewed by the IAEA who agreed in general with the conclusions indicating that the report provides valuable insights which should be used in the decision making process. The IAEA made suggestion for some changes. These comments were taken into account in the subsequent version. In early 1994 the new version was issued. The objective of this second project, in addition to revising the original study to reflect the IAEA comments, was to address the potential benefits from further improvements at NPP Kozloduy. The work on the second version was going on in parallel with the activities carried out in the mainframe of several NPP Kozloduy Units 1/4 Upgrading Program (WANO Six-Month Program, Program for the NPP Kozloduy Units 1-4 Upgrading, Twinning Program, etc.). And at last, a Top-Level Probabilistic Safety Study was carried out by EQE - Bulgaria and completed early in 1995 at the request of NPP Kozloduy. The objective of the project was the contribution of the different activities performed in the mainframe of the Program for the NPP Kozloduy Units 1-4 Safety Upgrading in the overall safety improvement to be assessed. 3 figs, 1 tab

26 CFR 1.897-1 - Taxation of foreign investment in United States real property interests, definition of terms.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Taxation of foreign investment in United States... Provisions § 1.897-1 Taxation of foreign investment in United States real property interests, definition of... respect to the taxation of foreign investments in U.S. real property interests and related matters. This...

Earth and Sky, Unit 1A

DEFF Research Database (Denmark)

Gammelgaard Nielsen, Anders

2011-01-01

The assignment known as ‘Earth and sky’ is the final first year course at Unit 1a. The aim of the assignment is to strengthen the student’s abilities to manage a project process individu- ally. The process involves develop- ing the ability to make independent decisions.The point of departure...... for the ‘Earth and sky’ assignment is ex- perience students acquired during their group study tour to Austra- lia. Building in particular on the re- search conducted on the Sydney Opera House and the architectur- al principles of spatial creation that this building represents....

Occurrence of C35-C45 polyprenols in filamentous and unicellular cyanobacteria

NARCIS (Netherlands)

Bauersachs, T.; Schouten, S.; Compaore, J.; Stal, L.J.; Sinninghe Damsté, J.S.

2010-01-01

Polyprenols, regular (head-to-tail) isoprenoid alcohols with 7–9 prenyl units, were tentatively identified in several cultivated cyanobacteria. Heptaprenol (C35), octaprenol (C40) and a suite of nonaprenols (C45) were present in unicellular and filamentous non-heterocystous cyanobacteria, while they

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

DEFF Research Database (Denmark)

Walter, Alexander M; Müller, Rainer; Tawfik, Bassam

2017-01-01

Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites. We developed a membrane-permeant, photoactivatable PI(4......,5)P2, which is loaded into cells in an inactive form and activated by light, allowing sub-second increases in PI(4,5)P2 levels. By combining this compound with electrophysiological measurements in mouse adrenal chromaffin cells, we show that PI(4,5)P2 uncaging potentiates exocytosis and identify...... synaptotagmin-1 (the Ca(2+) sensor for exocytosis) and Munc13-2 (a vesicle priming protein) as the relevant effector proteins. PI(4,5)P2 activation of exocytosis did not depend on the PI(4,5)P2-binding CAPS-proteins, suggesting that PI(4,5)P2 uncaging bypasses CAPS-function. Finally, PI(4,5)P2 uncaging...

Murine bone marrow Lin⁻Sca⁻1⁺CD45⁻ very small embryonic-like (VSEL cells are heterogeneous population lacking Oct-4A expression.

Directory of Open Access Journals (Sweden)

Krzysztof Szade

Full Text Available Murine very small embryonic-like (VSEL cells, defined by the Lin(-Sca-1(+CD45(- phenotype and small size, were described as pluripotent cells and proposed to be the most primitive hematopoietic precursors in adult bone marrow. Although their isolation and potential application rely entirely on flow cytometry, the immunophenotype of VSELs has not been extensively characterized. Our aim was to analyze the possible heterogeneity of Lin(-Sca(+CD45(- population and investigate the extent to which VSELs characteristics may overlap with that of hematopoietic stem cells (HSCs or endothelial progenitor cells (EPCs. The study evidenced that murine Lin(-Sca-1(+CD45(- population was heterogeneous in terms of c-Kit and KDR expression. Accordingly, the c-Kit(+KDR(-, c-Kit(-KDR(+, and c-Kit(-KDR(- subpopulations could be distinguished, while c-Kit(+KDR(+ events were very rare. The c-Kit(+KDR(- subset contained almost solely small cells, meeting the size criterion of VSELs, in contrast to relatively bigger c-Kit(-KDR(+ cells. The c-Kit(-KDR(-FSC(low subset was highly enriched in Annexin V-positive, apoptotic cells, hence omitted from further analysis. Importantly, using qRT-PCR, we evidenced lack of Oct-4A and Oct-4B mRNA expression either in whole adult murine bone marrow or in the sorted of Lin(-Sca-1(+CD45(-FSC(low population, even by single-cell qRT-PCR. We also found that the Lin(-Sca-1(+CD45(-c-Kit(+ subset did not exhibit hematopoietic potential in a single cell-derived colony in vitro assay, although it comprised the Sca-1(+c-Kit(+Lin(- (SKL CD34(-CD45(-CD105(+ cells, expressing particular HSC markers. Co-culture of Lin(-Sca-1(+CD45(-FSC(low with OP9 cells did not induce hematopoietic potential. Further investigation revealed that SKL CD45(-CD105(+ subset consisted of early apoptotic cells with fragmented chromatin, and could be contaminated with nuclei expelled from erythroblasts. Concluding, murine bone marrow Lin(-Sca-1(+CD45(-FSC(low cells are

CD45-mediated signaling pathway is involved in Rhizoctonia bataticola lectin (RBL)-induced proliferation and Th1/Th2 cytokine secretion in human PBMC

International Nuclear Information System (INIS)

Pujari, Radha; Eligar, Sachin M.; Kumar, Natesh; Nagre, Nagaraja N.; Inamdar, Shashikala R.; Swamy, Bale M.; Shastry, Padma

2012-01-01

Highlights: ► RBL, a potent mitogenic and complex N-glycan specific lectin binds to CD45 on PBMC. ► RBL triggers CD45-mediated signaling involved in activation of p38MAPK and STAT-5. ► Inhibition of CD45 PTPase signaling blocks RBL-induced ZAP70 phosphorylation. ► RBL-CD45 mediated signaling is crucial for RBL-induced immunodulatory activities. -- Abstract: We earlier reported the mitogenic and immunostimulatory activities of Rhizoctonia bataticola lectin (RBL), purified from phytopathogenic fungus R. bataticola in human PBMC. The lectin demonstrates specificity towards glycoproteins containing complex N-glycans. Since CD45-protein tyrosine phosphatase that abundantly expresses N-glycans is important in T-cell signaling, the study aimed to investigate the involvement of CD45 in the immunomodulatory activities of RBL. Flowcytometry and confocal microscopy studies revealed that RBL exhibited binding to PBMC and colocalized with CD45. The binding was comparable in cells expressing different CD45 isoforms-RA, -RB and -RO. CD45 blocking antibody reduced the binding and proliferation of PBMC induced by RBL. CD45-PTPase inhibitor dephostatin inhibited RBL–induced proliferation, expression of CD25 and pZAP-70. RBL-induced secretion of Th1/Th2 cytokines were significantly inhibited in presence of dephostatin. Also, dephostatin blocked phosphorylation of p38MAPK and STAT-5 that was crucial for the biological functions of RBL. The study demonstrates the involvement of CD45-mediated signaling in RBL-induced PBMC proliferation and Th1/Th2 cytokine secretion through activation of p38MAPK and STAT-5.

Analysis on Isolation Condenser Operation by Fukushima Daiichi Unit 1 Operators

International Nuclear Information System (INIS)

Kim, Man Cheol

2014-01-01

Fukushima Daiichi nuclear accident resulted in the core damage in three reactors and the release of considerable amount of radioactive material to the environment, not to mention significant social impact and anti-nuclear atmosphere all around the world. This paper provides a review of the findings related to shift operators' operation of the isolation condenser in Unit 1 to examine shift operators' response to the situation. Based on the review of the findings, a situation assessment model was developed to analyze shift operators' understanding on whether core cooling was successfully performed in Unit 1 through the operation of isolation condenser. It was found that lack of information could be one of the main causes for the failure in core cooling by the IC in Unit 1. It is also recommended that the differences in the mathematical model for the situation assessment and that of the real operator need to be further investigated

Analysis on Isolation Condenser Operation by Fukushima Daiichi Unit 1 Operators

Energy Technology Data Exchange (ETDEWEB)

Kim, Man Cheol [Chungang University, Seoul (Korea, Republic of)

2014-08-15

Fukushima Daiichi nuclear accident resulted in the core damage in three reactors and the release of considerable amount of radioactive material to the environment, not to mention significant social impact and anti-nuclear atmosphere all around the world. This paper provides a review of the findings related to shift operators' operation of the isolation condenser in Unit 1 to examine shift operators' response to the situation. Based on the review of the findings, a situation assessment model was developed to analyze shift operators' understanding on whether core cooling was successfully performed in Unit 1 through the operation of isolation condenser. It was found that lack of information could be one of the main causes for the failure in core cooling by the IC in Unit 1. It is also recommended that the differences in the mathematical model for the situation assessment and that of the real operator need to be further investigated.

Measurements of the neutron electric to magnetic form-factor ratio GEn/GMn via the 2H((rvec e), e(prime)(rvec n)) 1H reaction to Q2 = 1.45-(GeV/c)2

International Nuclear Information System (INIS)

Bradley Plaster; A.Yu. Semenov; A. Aghalaryan; Erick Crouse; Glen MacLachlan; Shigeyuki Tajima; William Tireman; Abdellah Ahmidouch; Brian Anderson; Hartmuth Arenhovel; Razmik Asaturyan; O. Baker; Alan Baldwin; David Barkhuff; Herbert Breuer; Roger Carlini; Michael Christy; Steve Churchwell; Leon Cole; Samuel Danagoulian; Donal Day; T. Eden; Mostafa Elaasar; Rolf Ent; Manouchehr Farkhondeh; Howard Fenker; John Finn; Liping Gan; Ashot Gasparian; Kenneth Garrow; Paul Gueye; Calvin Howell; Bitao Hu; Mark Jones; James Kelly; Cynthia Keppel; Mahbubul Khandaker; Wooyoung Kim; Stanley Kowalski; Allison Lung; David Mack; Richard Madey; D. Manley; Pete Markowitz; Joseph Mitchell; Hamlet Mkrtchyan; Allena Opper; Charles Perdrisat; Vina Punjabi; Brian Raue; Tilmann Reichelt; Joerg Reinhold; Julie Roche; Yoshinori Sato; Nikolai Savvinov; Irina Semenova; Wonick Seo; Neven Simicevic; Gregory Smith; Stepan Stepanyan; Vardan Tadevosyan; Liguang Tang; Shawn Taylor; Paul Ulmer; William Vulcan; John Watson; Steven Wells; Frank Wesselmann; Stephen Wood; Seunghoon Yang; Lulin Yuan; Wei-Ming Zhang; Hong Guo Zhu; Xiaofeng Zhu

2006-01-01

We report values for the neutron electric to magnetic form factor ratio, G En /G Mn , deduced from measurements of the neutron's recoil polarization in the quasielastic 2 H((rvec e), e(prime)(rvec n)) 1 H reaction, at three Q 2 values of 0.45, 1.13, and 1.45 (GeV/c) 2 . The data at Q 2 = 1.13 and 1.45 (GeV/c) 2 are the first direct experimental measurements of GEn employing polarization degrees of freedom in the Q 2 > 1 (GeV/c) 2 region and stand as the most precise determinations of GEn for all values of Q 2

40 CFR 45.140 - Budget and project period.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Budget and project period. 45.140 Section 45.140 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE TRAINING ASSISTANCE § 45.140 Budget and project period. The budget and project periods for...

12 CFR 34.45 - Appraiser independence.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Appraiser independence. 34.45 Section 34.45 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REAL ESTATE LENDING AND... appraiser shall be engaged directly by the regulated institution or its agent, and have no direct or...

Phosphatidylinositol 4,5-Bisphosphate (PtdIns(4,5)P2) Specifically Induces Membrane Penetration and Deformation by Bin/Amphiphysin/Rvs (BAR) Domains*

Science.gov (United States)

Yoon, Youngdae; Zhang, Xiuqi; Cho, Wonhwa

2012-01-01

Cellular proteins containing Bin/amphiphysin/Rvs (BAR) domains play a key role in clathrin-mediated endocytosis. Despite extensive structural and functional studies of BAR domains, it is still unknown how exactly these domains interact with the plasma membrane containing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and whether they function by a universal mechanism or by different mechanisms. Here we report that PtdIns(4,5)P2 specifically induces partial membrane penetration of the N-terminal amphiphilic α-helix (H0) of two representative N-BAR domains from Drosophila amphiphysin (dAmp-BAR) and rat endophilin A1 (EndoA1-BAR). Our quantitative fluorescence imaging analysis shows that PtdIns(4,5)P2-dependent membrane penetration of H0 is important for self-association of membrane-bound dAmp-BAR and EndoA1-BAR and their membrane deformation activity. EndoA1-BAR behaves differently from dAmp-BAR because the former has an additional amphiphilic α-helix that penetrates the membrane in a PtdIns(4,5)P2-independent manner. Depletion of PtdIns(4,5)P2 from the plasma membrane of HEK293 cells abrogated the membrane deforming activity of EndoA1-BAR and dAmp-BAR. Collectively, these studies suggest that the local PtdIns(4,5)P2 concentration in the plasma membrane may regulate the membrane interaction and deformation by N-BAR domain-containing proteins during clathrin-mediated endocytosis. PMID:22888025

Pressure tube replacement in Pickering NGS A units 1 and 2

International Nuclear Information System (INIS)

Irvine, H.S.; Bennett, E.J.; Talbot, K.H.

1986-10-01

Being able to technically and economically replace the most radioactive components (excluding the nuclear fuel) in operating reactors will help to ensure the ongoing acceptance of nuclear power as a viable energy source for the future. Ontario Hydro is well along the path to meeting the above objective for its CANDU-PHW reactors. Following the failure of a Zircaloy-II pressure tube in unit 2 of Pickering NGS A in August, 1983, Ontario Hydro has embarked on a program to replace all Zircaloy-II pressure tubes in units 1 and 2 at Pickering. This program integrates the in-house research, design, construction, and operating skills of a large utility (Ontario Hydro) with the skills of a national nuclear organization (Atomic Energy of Canada Limited) and the private engineering sector of the Canadian nuclear industry. The paper describes the background to the pressure tube failure in Pickering unit 2 and to the efforts incurred in understanding the failure mechanism and how similar failures are not expected for the zirconium-niobium pressure tube material used in all other large CANDU-PHW units after units 1 and 2 of Pickering NGS A. The tooling developed for the pressure tube replacement program is described as well as the organization to undertake the program in an operating nuclear station. The retubing of units 1 and 2 at Pickering NGS A is nearing a successful completion and shows the benefits of being able to integrate the various skills required for this success. Pressure tube replacement in a CANDU-PHW reactor is equivalent to replacement of the reactor vessel in a LWR. The fact that this replacement can be done economically and with acceptable radiation dose to workers augurs well for the continued viability of the use of nuclear energy for the benefit of mankind. (author)

22 CFR 226.45 - Cost and price analysis.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Cost and price analysis. 226.45 Section 226.45 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATION OF ASSISTANCE AWARDS TO U.S. NON-GOVERNMENTAL ORGANIZATIONS Post-award Requirements Procurement Standards § 226.45 Cost and price analysis. Some...

International review of Kursk unit 1 in-depth safety analysis report

International Nuclear Information System (INIS)

Chouha, M.; Bolshov, L.; Butcher, P.; Janke, R.; Parsons, T.; Weber, J.P.

2004-01-01

The paper presents the objectives, organisation, main findings and conclusions of the international review of the Kursk unit 1 safety analysis report (K1IRSR). The K1IRSR was administered by RISKAUDIT IRSN/GRS international and carried out by international experts from 7 western countries plus the Russian Federation, under the supervision of the safety review group (SRG) of the European bank for reconstruction and development (EBRD). The project was financed by the nuclear safety account (NSA) administered by the EBRD. The Russian experts worked under a contract with IBRAE financed by Rosenergoatom. The main conclusions were that the SAR followed a correct approach, broadly in line with Russian and international guidance documents, but needed improvement in structure and content. It established that the safety level of the unit has been increased significantly by the modernisation programme. The important deviations of the unit from current Russian regulations and the IAEA safety issues for RBMK are either fully resolved or are being addressed to the extent possible by compensatory measures to further reduce the risk. The K1IRSR experts have made a number of recommendations for improvement of the K1SAR. The authors agreed to take the recommendations into account in future revision of the K1SAR. (orig.)

10 CFR 1003.45 - OHA evaluation.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false OHA evaluation. 1003.45 Section 1003.45 Energy DEPARTMENT... OHA evaluation. (a)(1) The OHA may initiate an investigation of any statement in an application and utilize in its evaluation any relevant facts obtained by such investigation. The OHA may order the...

30 CFR 18.45 - Cable reels.

Science.gov (United States)

2010-07-01

... and locomotives shall maintain positive tension on the portable cable during reeling and unreeling. Such tension shall only be high enough to prevent a machine from running over its own cable(s). (e... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Cable reels. 18.45 Section 18.45 Mineral...

Hydrodesulfurization and hydrodearomatization activities of catalyst containing ETS-10 and AlPO{sub 4}-5 on Daqing FCC diesel

Energy Technology Data Exchange (ETDEWEB)

Ye Zhao; Baojian Shen; Wencheng Zhang; Ran Tian; Zhihua Zhang; Jinsen Gao [China University of Petroleum, Beijing (China). State Key Laboratory of Heavy Oil Processing

2008-08-15

A Ni-W loaded ETS-10/AlPO{sub 4}-5/Al{sub 2}O{sub 3} composite support catalyst was optimized and used in hydrodesulfurization (HDS) and hydrodearomatization (HDA) of Daqing FCC diesel feedstock. The result indicated that ETS-10 and AlPO{sub 4}-5 showed positive synergism effect. The effects of operating conditions on its catalytic performance were investigated by using a 100 mL hydrotreating test unit. The catalyst showed a remarkable HDS conversion of 99.9% and a HDA conversion of 73.2%. A clean diesel product with ultra-low sulfur content (<1.0 {mu}g/g) and very low polycyclic aromatic content (<2.0 wt.%) was obtained. Short communication. 21 refs., 4 tabs.

Cutoff value of HbA1c for predicting diabetes and prediabetes in a Chinese high risk population aged over 45.

Science.gov (United States)

Zhang, Ruyi; Wang, Jiao; Luo, Jinhua; Yang, Xiaoyan; Yang, Rui; Cai, Dehong; Zhang, Hua

2015-01-01

To evaluate the cutoff value of HbA1c for predicting diabetes and prediabetes in a Chinese high risk population aged over 45. A total of 619 people aged over 45 without diabetes were randomly recruited to complete Finnish Diabetes Risk Score (FINDRISC) questionnaire. 208 high-risk individuals (defined by Diabetes Risk Score >=9) had OGTT and HbA1c determined at the same time. In a Chinese population aged over 45, the best cutoff value of HbA1c for detecting diabetes and prediabetes was 5.8% and 5.4% respectively. The area under the receiver operating characteristic (AUROC) curve of HbA1c for detecting diabetes was 0.85 (95% CI: 0.80-0.90) and prediabetes was 0.62 (95% CI: 0.54-0.70). The combined use of HbA1c and fasting blood glucose (FPG) had larger AUROC than HbA1c alone (0.88, 95%CI: 0.83-0.92 in detecting diabetes vs 0.75, 95% CI: 0.67-0.82 in prediabetes), and had a higher sensitivity in predicting diabetes and higher specificity and positive predictive value (PPV) in predicting prediabetes. However, the AUROC between HbA1c alone and combined use in predicting diabetes was not significantly different (p=0.173). FINDRISC is feasible tool to screen people who are at high risk of diabetes. The cutoff values of HbA1c to diagnose diabetes and prediabetes in a Chinese high risk population aged over 45 were 5.8% and 5.4%, respectively. The sensitivity and specificity of HbA1c for detecting diabetes and prediabetes was relatively low, so that the combined use of HbA1c and FPG may be more effective in prediction.

Bruce unit 1 moderator to end shield cooling leak repairs

Energy Technology Data Exchange (ETDEWEB)

Boucher, P; Ashton, A [Ontario Hydro, Tiverton, ON (Canada). Bruce Nuclear Generating Station-A

1996-12-31

In October 1994, a leak developed between the heavy water Moderator System and the light water End Shield Cooling System at Ontario Hydro`s Bruce A Generating Station Unit 1. The interface between these two systems consists of numerous reactor components all within the reactor vessel. This paper describes the initial discovery and determination of the leak source. The techniques used to pinpoint the leak location are described. The repair strategies and details are outlined. Flushing and refilling of the Moderator system are discussed. The current status of the Unit 1 End Shield Cooling System is given with possible remedial measures for clean-up. Recommendations and observations are provided for future references. (author). 7 figs.

(p,3He) reactions on 1p shell nuclei at 41 and 45 MeV

International Nuclear Information System (INIS)

Rapp, V.

1982-01-01

In the present thesis the (p, 3 He) reactions on target nuclei of the 1p shell were studied. The measurements were performed at the isochronous cyclotron of the KFA Juelich. Angular distribution at 41 and 45 MeV to residual nuclear states in 7 Li, 8 Be, 9 Be, 10 B, 11 B, 12 C, 13 C, and 14 N. were evaluated. (orig.) [de

2-Amino-1-methyl-6-(5-hydroxy-)phenylimidazo[4,5-b]pyridine (5-OH-PhIP), a biomarker for the genotoxic dose of the heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

DEFF Research Database (Denmark)

Frandsen, H; Frederiksen, H; Alexander, J

2002-01-01

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic amine formed during ordinary cooking. PhIP is metabolically activated by CYP P450 mediated N-hydroxylation followed by phase II esterification. The ultimate mutagenic metabolite reacts with DNA...

Solvent-free one-pot cyclization and acetylation of chalcones: Synthesis of some 1-acetyl pyrazoles and spectral correlations of 1-(3-(3,4-dimethylphenyl-5-(substituted phenyl-4,5-dihydro-1H-pyrazole-1-yl ethanones

Directory of Open Access Journals (Sweden)

G. Thirunarayanan

2016-11-01

Full Text Available One-pot synthesis of some 1N-acetyl pyrazoles including 1-(3-(3,4-dimethylphenyl-5-(substituted phenyl-4,5-dihydro-1H-pyrazole-1-yl ethanones has been achieved via solvent-free microwave irradiation using substituted chalcones, hydrazine hydrate and acetic anhydride in the presence of catalytic amount of fly-ash: PTS catalyst. The yield of these 1N-acetyl pyrazole derivatives is more than 75%. The synthesized 1N-acetyl pyrazoline derivatives were characterized by their physical constants and spectral data. The infrared spectral νCN and CO (cm−1 frequencies, NMR chemical shifts (δ, ppm of Ha, Hb, Hc, CH3 protons, CN, CO and CH3 carbons of 1-(3-(3,4-dimethylphenyl-5-(substituted phenyl-4,5-dihydro-1H-pyrazole-1-yl ethanones have been assigned and correlated with Hammett substituent constants and Swain-Lupton’s parameters using single and multi-regression analysis. From the results of statistical analyses, the effect of substituents on the above group frequencies and chemical shifts of the acetylated pyrazoles were discussed.

75 FR 60667 - Airworthiness Directives; Learjet Inc. Model 45 Airplanes

Science.gov (United States)

2010-10-01

..., except Federal holidays. For service information identified in this proposed AD, contact Learjet, Inc... Docket Management Facility between 9 a.m. and 5 p.m., Monday through Friday, except Federal holidays. The... this AD. (1) Serial numbers 45-2001 through 45-2114 inclusive, 45-2116 through 45-2120 inclusive, 45...

49 CFR 19.45 - Cost and price analysis.

Science.gov (United States)

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Cost and price analysis. 19.45 Section 19.45... Requirements Procurement Standards § 19.45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price...

Gadd45 α expression in preeclampsia placenta and the effect of Gadd45 α on trophoblast HTR8/Svneo

Directory of Open Access Journals (Sweden)

Li Wang

2016-01-01

Full Text Available Objective: To study the expression of Gadd45 α in preeclampsia placenta and the regulating effect of Gadd45 α knockdown on trophoblast HTR8/Svneo. Methods: Preeclampsia placenta tissue and normal placenta tissue were collected, and mRNA contents and protein contents of Gadd45 α were detected by fluorescent quantitative PCR and Western blotting respectively; trophoblast cells HTR8/Svneo were cultured and after transfection of Gadd45 α siRNA, cell invasion ability and expression of invasion-assiotiated molecules were detected. Results: mRNA content and protein content of Gadd45 α in preeclampsia placenta tissue were higher than those in normal placenta tissue; after transfection of Gadd45 α siRNA, mRNA content and protein content of Gadd45 α in HTR8/Svneo cells significantly decreased, and the number of invasive cells as well as expression of MMP1, MMP2, MMP3 and MMP9 significantly increased. Conclusion: The expression of Gadd45 α in preeclampsia placenta abnormally increases; inhibting the expression of Gadd45 α in trophoblasts HTR8/Svneo can promote invasion and increase the expression of MMPs molecules.

The neutron electric form factor to Q² = 1.45 (GeV/c)²

Energy Technology Data Exchange (ETDEWEB)

Plaster, Bradley [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

2004-02-01

The nucleon elastic electromagnetic form factors are fundamental quantities needed for an understanding of nucleon and nuclear electromagnetic structure. The evolution of the Sachs electric and magnetic form factors with Q², the square of the four-momentum transfer, is related to the distribution of charge and magnetization within the nucleon. High precision measurements of the nucleon form factors are essential for stringent tests of our current theoretical understanding of confinement within the nucleon. Measurements of the neutron form factors, in particular, those of the neutron electric form factor, have been notoriously difficult due to the lack of a free neutron target and the vanishing integral charge of the neutron. Indeed, a precise measurement of the neutron electric form factor has eluded experimentalists for decades; however, with the advent of high duty-factor polarized electron beam facilities, experiments employing polarization degrees of freedom have finally yielded the first precise measurements of this fundamental quantity. Following a general overview of the experimental and theoretical status of the nucleon form factors, a detailed description of an experiment designed to extract the neutron electric form factor from measurements of the neutron's recoil polarization in quasielastic 2H(e, e')1H scattering is presented. The experiment described here employed the Thomas Jefferson National Accelerator Facility's longitudinally polarized electron beam, a magnetic spectrometer for detection of the scattered electron, and a neutron polarimeter designed specifically for this experiment. Measurements were conducted at three Q² values of 0.45, 1.13, and 1.45 (GeV/c)², and the final results extracted from an analysis of the data acquired in this experiment are reported and compared with recent theoretical predictions for the nucleon form factors.

27 CFR 45.45b - Notice for roll-your-own tobacco.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice for roll-your-own tobacco. 45.45b Section 45.45b Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) TOBACCO REMOVAL OF TOBACCO PRODUCTS AND CIGARETTE PAPERS...

Impact of relaxation training according to Yoga In Daily Life® system on self-esteem after breast cancer surgery.

Science.gov (United States)

Kovačič, Tine; Kovačič, Miha

2011-12-01

The purpose of this pilot study was to gather information on the immediate and short-term effects of relaxation training according to the Yoga In Daily Life(®) system on the self-esteem of patients with breast cancer. This is a parallel-groups design. Baseline interventions took place at the Institute for Oncology of Ljubljana (Slovenia). At discharge, the experimental group was issued with audiocassette recordings containing the instructions for relaxation training to be practiced individually at home for an additional 3 weeks. The convenience sample of 32 patients with breast cancer was recruited from an accessible population of hospitalized women. Patients were randomized to the experimental (n=16) and to the control group (n=16). Both groups received the same standard physiotherapy for 1 week, while the experimental group additionally received a group relaxation training sessions according to the Yoga in Daily Life(®) system. At discharge, the experimental group was issued with audiocassette recordings containing similar instructions for relaxation training to be practiced individually at home for an additional 3 weeks. Outcome measures were obtained by blinded investigators (physiotherapists) using standardized questionnaires (Rosenberg Self-Esteem Scale) at baseline (after the surgery); at 1 week (1 week postattendance; at discharge); and at 4 weeks (4 weeks postattendance); prior the commencement of radiation. Analysis of variance showed that there were statistically significant differences between the experimental and control group in all measuring self-esteem scores over the study period (pp>0.05). The results indicate that relaxation training according to the Yoga in Daily Life system could be a useful clinical physiotherapy intervention for patients who have breast cancer and who are experiencing low self-esteem. Although this kind of relaxation training can be applied to clinical oncology in Slovenia, more studies need to be done.

5-(4-Methylphenylsulfonyl-1,3-dithiolo[4,5-c]pyrrole-2-thione

Directory of Open Access Journals (Sweden)

Ning-Juan Zheng

2012-04-01

Full Text Available The asymmetric unit of the title compound, C12H9NO2S4, contains one half-molecule with the N, two S amd four C atoms lying on a mirror plane. The molecule exhibits a V-shaped conformation, with a dihedral angle of 87.00 (7° between the benzene and dithiolopyrrole rings. The methyl group was treated as rotationally disordered between two orientations in a 1:1 ratio. In the crystal, weak C—H...O hydrogen bonds link the molecules into chains in [010].

Forest landscape restoration: linkages with stream fishes of the southern United States

Science.gov (United States)

Melvin L. Warren

2012-01-01

With well over 600 native species, the southern United States supports one of the richest temperate freshwater fish faunas on Earth (Fig. 10.1 ). Unfortunately, an expert review revealed that 27% (188 taxa) of southern fishes are endangered, threatened, or vulnerable (Warren et al. 2000 ) and that 16–18% of native fishes are imperiled in 45 of 51 major southern river...

41 CFR 101-45.002 - Gold.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Gold. 101-45.002 Section... PERSONAL PROPERTY § 101-45.002 Gold. (a) Gold will be sold in accordance with this section and part 102-38 of the Federal Management Regulation. (b) Sales of gold shall be processed to— (1) Use the sealed bid...

The contract for the completion and commissioning of Cernavoda NPP - Unit

International Nuclear Information System (INIS)

2001-01-01

On May 18, 2001 the commercial contract for the completion and commissioning of the Cernavoda NPP Unit 2 has been signed by Nuclearelectrica National Company (SNN SA) and its partners, AECL-Canada and ANSALDO-Italy. This contract represents a continuation of the cooperation with AECL-Canada (the owner of the licence and the designer of the nuclear part of Cernavoda NPP Unit1) and ANSALDO-Italy (the designer of the conventional part of Cernavoda NPP Unit1). The completion is scheduled to last for 54 months (4.5 years) since the date the contract takes effect and the nuclear reactor start-up (the first criticality) is scheduled for the 49 th month. The total negotiated cost for the completion was estimated to amount to 689 million dollars, against the 750 million dollars initially estimated. The works at the site will be managed by an integrated staff team of specialized personnel form AECL-Canada (111 positions), ANSALDO-Italy (72 positions) and Romania (1200 positions)

RFQ1 diagnostic devices

International Nuclear Information System (INIS)

Chidley, B.G.; Arbique, G.M.; de Jong, M.S.; McMichael, G.E.; Michel, W.L.; Smith, B.H.

1991-01-01

The diagnostic devices in use on RFQ1 will be described. They consist of a double-slit emittance-measuring unit, a 45 degree deflection energy-analysis magnet, parametric current transformers, optical beam sensors, beam-stop current monitors, and an x-ray end-point analyzer. All of these devices are able to operate up to the full output current of RFQ1 (75 mA cw at 0.6 MeV)

M45

Science.gov (United States)

Murdin, P.

2000-11-01

M45 is better known as the Pleiades, a young open cluster in Taurus. Again, this is a very bright (1.6 mag) object known since antiquity. The Pleiades are sometimes referred to as the `Seven Sisters' since that is the number of stars normally visible to the naked eye. In Greek mythology these represent Pleione and her daughters with Atlas: Alcyone, Asterope (a double star), Electra, Maia, Merope,...

X-ray structure, semi-empirical MO calculations and π-electron delocalization of 1-cyanoacetyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1 H-pyrazoles

Science.gov (United States)

Martins, Marcos A. P.; Moreira, Dayse N.; Frizzo, Clarissa P.; Campos, Patrick T.; Longhi, Kelvis; Marzari, Mara R. B.; Zanatta, Nilo; Bonacorso, Helio G.

2010-04-01

The structure of three 1-cyanoacetyl-3-alkyl[aryl]-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1 H-pyrazoles ( 1- 3) has been determined by X-ray diffractometry. The 4,5-dihydro-1 H-pyrazole rings were obtained as almost planar structures showing RMS deviation at a range of 0.0196-0.0736 Å. The data demonstrate that the molecular packing is dependent on the substituent present in each molecule. In addition, a computational investigation using semi-empirical AM1 and RM1 methods was performed in order to investigate the correlation between experimental and calculated geometrical parameters. The data obtained suggest that the structural data furnished by the AM1 method is in better agreement with those experimentally determined for the above compounds. An analysis of the π-electron delocalization by HOMA calculations indicate that there is a hyperconjugation effect in the imine group toward to phenyl group at ring 3-position of compound 2, and that this resonance effect decrease in compounds 1 and 3. In addition, it was showed that bond N(1) and C(6) do not have an amide character. Thus, the O(6)-C(6)-N(1)-N(2)-C(3) fragment is not completely delocalized mainly due to the low π-electron delocalization in N(1)-N(2) bond for all compounds.

38 CFR 1.205 - Notification to the Attorney General or United States Attorney's Office.

Science.gov (United States)

2010-07-01

... Attorney General or United States Attorney's Office. 1.205 Section 1.205 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Referrals of Information Regarding Criminal Violations § 1.205 Notification to the Attorney General or United States Attorney's Office. VA police and/or...

78 FR 77726 - Exelon Generation Company, LLC Three Mile Island Nuclear Station, Unit 1

Science.gov (United States)

2013-12-24

... Three Mile Island Nuclear Station, Unit 1 AGENCY: Nuclear Regulatory Commission. ACTION: Exemption... License No. DPR-50, which authorizes operation of the Three Mile Island Nuclear Station, Unit 1 (TMI-1... Facility Operating License No. DPR-50, which authorizes operation of the Three Mile Island Nuclear Station...

22 CFR 145.45 - Cost and price analysis.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Cost and price analysis. 145.45 Section 145.45....45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be accomplished in various...

SPOKEN COCHABAMBA QUECHUA, UNITS 1-12.

Science.gov (United States)

LASTRA, YOLANDA; SOLA, DONALD F.

THE FIRST OF TWO VOLUMES PREPARED FOR TEACHING THE COCHABAMBA DIALECT OF QUECHUA TO SPEAKERS OF ENGLISH, THIS DOCUMENT IS MADE UP OF 12 UNITS THAT COMPRISE A 6-WEEK INTENSIVE COURSE OF 20 CLASS HOURS A WEEK. EACH UNIT CONSISTS OF ONE OR MORE DIALOGS TO BE MEMORIZED, A DIALOG REVIEW, A SECTION ON GRAMMAR WITH ACCOMPANYING EXERCISES, CONVERSATION,…

29 CFR 95.45 - Cost and price analysis.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Cost and price analysis. 95.45 Section 95.45 Labor Office of... Procurement Standards § 95.45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be...

46 CFR 30.10-45 - Ocean-TB/O.

Science.gov (United States)

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Ocean-TB/O. 30.10-45 Section 30.10-45 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-45 Ocean—TB/O. Under this designation shall be included all tank vessels normally navigating the waters of any ocean or...

Attributes for NHDPlus Catchments (Version 1.1) for the Conterminous United States: Normalized Atmospheric Deposition for 2002, Ammonium (NH4)

Science.gov (United States)

Wieczorek, Michael; LaMotte, Andrew E.

2010-01-01

This data set represents the average normalized atmospheric (wet) deposition, in kilograms, of Ammonium (NH4) for the year 2002 compiled for every catchment of NHDPlus for the conterminous United States. Estimates of NH4 deposition are based on National Atmospheric Deposition Program (NADP) measurements (B. Larsen, U.S. Geological Survey, written commun., 2007). De-trending methods applied to the year 2002 are described in Alexander and others, 2001. NADP site selection met the following criteria: stations must have records from 1995 to 2002 and have a minimum of 30 observations. The NHDPlus Version 1.1 is an integrated suite of application-ready geospatial datasets that incorporates many of the best features of the National Hydrography Dataset (NHD) and the National Elevation Dataset (NED). The NHDPlus includes a stream network (based on the 1:100,00-scale NHD), improved networking, naming, and value-added attributes (VAAs). NHDPlus also includes elevation-derived catchments (drainage areas) produced using a drainage enforcement technique first widely used in New England, and thus referred to as "the New England Method." This technique involves "burning in" the 1:100,000-scale NHD and when available building "walls" using the National Watershed Boundary Dataset (WBD). The resulting modified digital elevation model (HydroDEM) is used to produce hydrologic derivatives that agree with the NHD and WBD. Over the past two years, an interdisciplinary team from the U.S. Geological Survey (USGS), and the U.S. Environmental Protection Agency (USEPA), and contractors, found that this method produces the best quality NHD catchments using an automated process (USEPA, 2007). The NHDPlus dataset is organized by 18 Production Units that cover the conterminous United States. The NHDPlus version 1.1 data are grouped by the U.S. Geologic Survey's Major River Basins (MRBs, Crawford and others, 2006). MRB1, covering the New England and Mid-Atlantic River basins, contains NHDPlus

45 CFR 402.12 - Use of SLIAG Funds for Costs Incurred Prior to October 1, 1987.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 2 2010-10-01 2010-10-01 false Use of SLIAG Funds for Costs Incurred Prior to... STATE LEGALIZATION IMPACT ASSISTANCE GRANTS Use of Funds § 402.12 Use of SLIAG Funds for Costs Incurred... funds provided under this part of costs incurred prior to October 1, 1987. (b) A State may use funds...

Evaluation of Watts Bar Nuclear Plant Unit 1 Technical Specifications

International Nuclear Information System (INIS)

Baxter, D.E.; Bruske, S.J.

1985-08-01

This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the Watts Bar Nuclear Plant Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the assumption of the Final Safety Analysis Report (FSAR) as amended, and the requirements of the Safety Evaluation Report (SER) as supplemented. A comparative audit of the FSAR as amended, and the SER as supplemented was performed with the Watts Bar T/S. Several discrepancies were identified and subsequently resolved through discussions with the cognizant NRC reviewer, NRC staff reviewers and/or utility representatives. The Watts Bar Nuclear Plant Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR and SER

Evaluation of Shoreham Nuclear Power Station, Unit 1 technical specifications

International Nuclear Information System (INIS)

Baxter, D.E.; Bruske, S.J.

1985-08-01

This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the Shoreham Nuclear Power Station Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the assumptions of the Final Safety Analysis Report (FSAR) as amended, and the requirements of the Safety Evaluation Report (SER) as supplemented. A comparative audit of the FSAR as amended, and the SER as supplemented was performed with the Shoreham T/S. Several discrepancies were identified and subsequently resolved through discussions with the cognizant NRC reviewer, NRC staff reviewers and/or utility representatives. The Shoreham Nuclear Power Station Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR and SER

Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase

DEFF Research Database (Denmark)

Ballabeni, Andrea; Zamponi, Raffaela; Caprara, Greta

2009-01-01

The initiation of DNA replication is a tightly controlled process that involves the formation of distinct complexes at origins of DNA replication at specific periods of the cell cycle. Pre-Replicative Complexes are formed during telophase and early G1. They rearrange at the start of S phase to form...... pre-Initiation Complexes, which are a prerequisite for DNA replication. The CDT1 protein is required for the formation of the pre-Replicative Complexes. Here we show that human CDT1 associates with the CDC7 kinase and recruits CDC45 to chromatin. Moreover, we show that the amount of CDT1 bound...

Exposure to radiofrequency radiation from diathermy units in medicine

International Nuclear Information System (INIS)

Hrnjak, M.; Zivkovic, D.; Milicevic, L.

1998-01-01

Intensities of microwave (MW) and radio wave (short wave) radiation to whom personnel occupied in use of radiofrequency (RF) diathermy in physical therapy could be exposed were measured in two hospitals, in two therapy wards. The Narda Microwave Corp. (USA) Broadband Radiation Meter - Model 8616, with appropriate probes, was used for measurements. The measurements were performed around the 3 types of diathermy units in various ways of application. Results of the measurements showed that the intensities of short waves radiation around the applicators, cables and units (at the distance of 30 cm) ranged from 187 mW/cm sup 2 , and on the majority of measuring points were considerably over the upper exposure limit of 1,22 mW/cm sup 2 (according to JUS N.NO.205:1190 limits of exposure to RF fields). Intensities of microwave radiation in the vicinity of units and patient range from <0,002 to 1,45 mW/cm sup 2. The intensities of MW radiation are over the exposure limit of 1 mW/cm sup 2 in two measuring points. Results of measurements show that personnel occupied in use of microwave and short wave diathermy in medicine could be regularly exposed to radiation, and that this radiation has considerably high intensity in the vicinity of the therapy unit and patient (author)

Vibration Spectrum Analysis for Indicating Damage on Turbine and Steam Generator Amurang Unit 1

Directory of Open Access Journals (Sweden)

Beny Cahyono

2017-12-01

Full Text Available Maintenance on machines is a mandatory asset management activity to maintain asset reliability in order to reduce losses due to failure. 89% of defects have random failure mode, the proper maintenance method is predictive maintenance. Predictive maintenance object in this research is Steam Generator Amurang Unit 1, which is predictive maintenance is done through condition monitoring in the form of vibration analysis. The conducting vibration analysis on Amurang Unit 1 Steam Generator is because vibration analysis is very effective on rotating objects. Vibration analysis is predicting the damage based on the vibration spectrum, where the vibration spectrum is the result of separating time-based vibrations and simplifying them into vibrations based on their frequency domain. The transformation of time-domain-wave into frequency-domain-wave is using the application of FFT, namely AMS Machinery. The measurement of vibration value is done on turbine bearings and steam generator of Unit 1 Amurang using Turbine Supervisory Instrument and CSI 2600 instrument. The result of this research indicates that vibration spectrum from Unit 1 Amurang Power Plant indicating that there is rotating looseness, even though the vibration value does not require the Unit 1 Amurang Power Plant to stop operating (shut down. This rotating looseness, at some point, can produce some indications that similar with the unbalance. In order to avoid more severe vibrations, it is necessary to do inspection on the bearings in the Amurang Unit 1 Power Plant.

Fuel failure at the Laguna Verde unit 1- during Cycle 4

International Nuclear Information System (INIS)

Espinosa Vega, Juan Manuel

1996-01-01

The present work describes the event occurred at the Laguna Verde nuclear power plants Unit 1 during its fourth cycle ensembles; the first failure, by means of a test of power suppression, and the second one, during the sipping accomplished in the four refuelling of the unit. Also it describes the re-evaluation of the event accomplished by the licenser, the manufacturer and the Mexican agency

FIND: Douglas Point Nuclear Generating Station, Units 1 and 2

International Nuclear Information System (INIS)

Moore, M.M.

1975-12-01

This index is presented as a guide to microfiche items 1 through 136 in Docket 50448, which was assigned to Potomac Electric Power Company's Application for Licenses to construct and operate Douglas Point Nuclear Generating Station, Units 1 and 2. Information received from August, 1973 through July, 1975 is included

Corrective Action Decision Document/Closure Report for Corrective Action Unit 375: Area 30 Buggy Unit Craters, Nevada National Security Site, Nevada, Revision 0

Energy Technology Data Exchange (ETDEWEB)

Patrick Matthews

2011-08-01

Corrective Action Unit 375 comprises three corrective action sites (CASs): (1) 25-23-22, Contaminated Soils Site; (2) 25-34-06, Test Cell A Bunker; and (3) 30-45-01, U-30a, b, c, d, e Craters. The purpose of this CADD/CR is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 375 based on the implementation of corrective action of closure in place with administrative controls at CAS 25-23-22, no further action at CAS 25-34-06, and closure in place with administrative controls and removal of potential source material (PSM) at CAS 30-45-01. Corrective action investigation (CAI) activities were performed from July 28, 2010, through April 4, 2011, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 375: Area 30 Buggy Unit Craters. The approach for the CAI was divided into two facets: investigation of the primary release of radionuclides, and investigation of other releases (migration in washes and chemical releases). The purpose of the CAI was to fulfill data needs as defined during the data quality objective (DQO) process. The CAU 375 dataset of investigation results was evaluated based on the data quality assessment. This assessment demonstrated the dataset is acceptable for use in fulfilling the DQO data needs. Investigation results were evaluated against final action levels (FALs) established in this document. A radiological dose FAL of 25 millirem per year was established based on the Remote Work Area exposure scenario (336 hours of annual exposure). Radiological doses exceeding the FAL were assumed to be present within the default contamination boundaries at CASs 25-23-22 and 30-45-01. No contaminants were identified at CAS 25-34-06, and no corrective action is necessary. Potential source material in the form of lead plate, lead-acid batteries, and oil within an abandoned transformer were identified at CAS 30-45-01, and corrective actions were undertaken that

Vogtle Unit 1 readiness review: Assessment of Georgia Power Company readiness review pilot program

International Nuclear Information System (INIS)

Lewis, G.

1987-09-01

Georgia Power Company (GPC) performed a readiness review at Vogtle Unit 1 as a pilot program. The pilot program was a new and innovative approach for the systematic and disciplined review, with senior management involvement, of GPC's implementation of design, construction, and operational readiness processes. The program's principal objective was to increase the level of assurance that quality programs at Vogtle Unit 1 have been accomplished in accordance with regulatory requirements. This report assesses the effectiveness of the GPC's readiness review pilot program (RRPP) at Vogtle Unit 1. It includes (1) an overview of what was experienced during the program's implementation, (2) an assessment of how well program objectives were met, and (3) lessons learned on the future use of the readiness review concept. Overall, GPC and the NRC staff believe that the RRPP at Vogtle Unit 1 was a success and that the program provided significant added assurance that Vogtle Unit 1 licensing commitments and NRC regulations have been adequately implemented. Although altering the NRC licensing review process for the few plants still in the construction pipeline may not be appropriate, licensees may benefit significantly by performing readiness reviews on their own initiative as GPC did for Vogtle. (7 refs.)

First evidence for the two-proton of 45Fe

International Nuclear Information System (INIS)

Pfuetzner, M.; Bingham, C.

2002-06-01

Decays of five 45 Fe atoms have been observed at the Fragment Separator of GSI. Whereas one event is consistent with β decay of 45 Fe accompanied by the emission of a 10 MeV proton, four decays are consistent with the emission of particle(s) of total energy of 1.1 ± 0.1 MeV. This observation represents the first evidence for two-proton ground state radioactivity, a decay mode predicted for 45 Fe. The time distribution of the observed decay events corresponds to a half-life of 3.2 -1.0 +2.6 ms. (orig.)

A Ru(II) complex with 2-(4-(methylsulfonyl)phenyl)-1H-imidazo[4,5- f][1,10]phenanthroline: Synthesis, characterization, and acid-base and DNA-binding properties

Science.gov (United States)

Gao, Jie; Wang, Zhi-Ping; Yuan, Cui-Li; Jia, Hai-Shun; Wang, Ke-Zhi

2011-09-01

A new Ru(II) complex of [Ru(bpy) 2(Hmspip)]Cl 2 {in which bpy = 2,2'-bipyridine, Hmspip = 2-(4-(methylsulfonyl)phenyl)-1 H-imidazo[4,5- f][1,10]phenanthroline} have been synthesized and characterized. The ground- and excited-state acid-base properties of [Ru(bpy) 2(Hmspip)]Cl 2 and its parent complex of [Ru(bpy) 2(Hpip)]Cl 2 {Hpip = 2-phenyl-1H-imidazo[4,5- f][1,10]phenanthroline} have been studied by UV-visible (UV-vis) and emission spectrophotometric pH titrations. [Ru(bpy) 2(Hmspip)]Cl 2 acts as a calf thymus DNA intercalators with a binding constant of 4.0 × 10 5 M -1 in buffered 50 mM NaCl, as evidenced by UV-vis and luminescence titrations, steady-state emission quenching by [Fe(CN) 6] 4-, DNA competitive binding with ethidium bromide, reverse salt titrations and viscosity measurements.

Evaluation of Steam Generator Level behavior for Determination of Turbine Runback rate on COPs trip for Yonggwang 1 and 2 Power Uprating Units

International Nuclear Information System (INIS)

Lee, Kyung Jin; Hwang, Su Hyun; Yoo, Tae Geun; Chung, Soon Il; An, Byung Chang; Park, Jung Gu

2010-01-01

4.5% power uprate project has been progressing for the first time in Yonggwang 1 and 2(YGN1 and 2). Reviews for design change due to the power uprate were accomplished. Steam generator level behavior was one of the most important parameters because it could be cause of reactor trip or turbine trip. As the results of the reviews, YGN1 and 2 had to reassess it for change of turbine runback rate when turbine runback occurs due to the condensate operating pumps (COP) trip. This study has been carried out for evaluating the steam generator level behavior for determination of turbine runback rate on COPs trip for Yonggwang 1 and 2 Power Uprating Units. The steam generator water level evaluation program for YGN1 and 2 (SLEP-Y1) has been developed for it. The program includes models for the steam generator water level response. SLEP-Y1 is programmed with advanced continuous system simulation language (ACSL). The language has been used to simulate physical systems as a commercial tool used to evaluate system designs

An improved design of QFE dosimeter charging unit

International Nuclear Information System (INIS)

Speight, R.G.; Clifton, J.J.

1976-02-01

The availability of commercial charging units for quartz fibre electroscope dosimeters (QFEs) in the United Kingdom has been limited to small battery units intended for use in laboratory conditions. The use of large numbers of QFEs by semi-skilled staff has resulted in damage to many dosimeters, particularly at the charging pins. Difficulties have also been experienced in the viewing of the scale and fibre in non-laboratory lighting conditions. These problems have resulted in the development of a robust charging and viewing unit, which is described in this report. The new unit which is mains electricity powered, is contained in a case 230 x 305 x 150 mm weighing 4.5 kg. (U.K.)

A 1.5 GFLOPS Reciprocal Unit for Computer Graphics

DEFF Research Database (Denmark)

Nannarelli, Alberto; Rasmussen, Morten Sleth; Stuart, Matthias Bo

2006-01-01

The reciprocal operation 1/d is a frequent operation performed in graphics processors (GPUs). In this work, we present the design of a radix-16 reciprocal unit based on the algorithm combining the traditional digit-by-digit algorithm and the approximation of the reciprocal by one Newton-Raphson i...

Xe N4,5O-OOO satellite Auger spectrum

International Nuclear Information System (INIS)

Partanen, L; Huttula, M; Heinaesmaeki, S; Aksela, H; Aksela, S

2007-01-01

The N 4,5 O 1,2,3 -O 1,2,3 O 2,3 O 2,3 Auger transitions, appearing as a satellite structure in the N 4,5 -OO Auger spectrum of xenon, were studied in detail. By measuring the N 4,5 O-OOO satellite Auger spectrum both below and above the 4p ionization threshold, we were able to separate the satellite production via the direct photo-double ionization and the Auger cascade from the 4p states. The N 3 -N 4,5 O 2,3 Coster-Kronig transitions and the subsequent N 4,5 O 2,3 -O 2,3 O 2,3 O 2,3 satellite Auger transitions were calculated using the HF wavefunctions and the most intense satellite lines were assigned. The Xe N 4,5 O-OOO satellite spectrum was compared with the previously studied Kr M 4,5 N-NNN satellite Auger spectrum. The 5s orbital in Xe was found to reveal more pronounced electron correlation than the 4s orbital in Kr

Estimates of Incidence and Prevalence of Visual Impairment, Low Vision, and Blindness in the United States.

Science.gov (United States)

Chan, Tiffany; Friedman, David S; Bradley, Chris; Massof, Robert

2018-01-01

Updated estimates of the prevalence and incidence rates of low vision and blindness are needed to inform policy makers and develop plans to meet the future demands for low vision rehabilitation services. To provide updated estimates of the incidence and prevalence of low vision and blindness in the United States. Visual acuity measurements as a function of age from the 2007-2008 National Health and Nutrition Examination Survey, with representation of racial and ethnic groups, were used to estimate the prevalence and incidence of visual impairments. Data from 6016 survey participants, ranging in age from younger than 18 years to older than 45 years, were obtained to estimate prevalence rates for different age groups. Incidence and prevalence rates of low vision (best-corrected visual acuity [BCVA] in the better-seeing eye of United States were estimated, using the 2010 US census data by age, from the rate models applied to the census projections for 2017, 2030, and 2050. Data were collected from November 1, 2007, to October 31, 2008. Data analysis took place from March 31, 2016, to March 19, 2017. Prevalence and incidence rates of low vision and blindness in the United States. Of the 6016 people in the study, 1714 (28.4%) were younger than 18 years of age, 2358 (39.1%) were 18 to 44 years of age, and 1944 (32.3%) were 45 years of age or older. There were 2888 male (48%) and 3128 female (52%) participants. The prevalence of low vision and blindness for older adults (≥45 years) in the United States in 2017 is estimated to be 3 894 406 persons (95% CI, 3 034 442-4 862 549 persons) with a BCVA less than 20/40, 1 483 703 persons (95% CI, 968 656-2 370 513 persons) with a BCVA less than 20/60, and 1 082 790 persons (95% CI, 637 771-1 741 864 persons) with a BCVA of 20/200 or less. The estimated 2017 annual incidence (projected from 2010 census data) of low vision and blindness among older adults (≥45 years) in the United States is 481�

Conformance to Regulatory Guide 1.97, River Bend Station, Unit No. 1 (Docket No. 50-458)

International Nuclear Information System (INIS)

Udy, A.C.

1985-08-01

This EG and G, Inc., report reviews the submittals for Regulatory Guide 1.97, Revision 3, for the River Bend Station, Unit No. 1. Any exception to Regulatory Guide 1.97 is evaluated and those areas where sufficient basis for acceptability is not provided are identified. 8 refs

Quad-Cities Station, Units 1 and 2. Annual operating report for 1976

International Nuclear Information System (INIS)

1976-01-01

Net electrical power generated by Unit 1 was 3,393,062 MWH with the generator on line 5,703.0 hrs. Unit 2 generated 4,304,684 MWH with the generator on line 7,145.3 hrs. Information is presented concerning modifications, maintenance, power generation, shutdowns, occupational radiation exposures, and organization

Cardiac surgery fast-track treatment in a postanesthetic care unit: six-month results of the Leipzig fast-track concept.

Science.gov (United States)

Ender, Joerg; Borger, Michael Andrew; Scholz, Markus; Funkat, Anne-Kathrin; Anwar, Nadeem; Sommer, Marcus; Mohr, Friedrich Wilhelm; Fassl, Jens

2008-07-01

The authors compared the safety and efficacy of a newly developed fast-track concept at their center, including implementation of a direct admission postanesthetic care unit, to standard perioperative management. All fast-track patients treated within the first 6 months of implementation of our direct admission postanesthetic care unit were matched via propensity scores and compared with a historical control group of patients who underwent cardiac surgery prior to fast-track implementation. A total of 421 fast-track patients were matched successfully to 421 control patients. The two groups of patients had a similar age (64 +/- 13 vs. 64 +/- 12 yr for fast-track vs. control, P = 0.45) and European System for Cardiac Operative Risk Evaluation-predicted risk of mortality (4.8 +/- 6.1% vs. 4.6 +/- 5.1%, P = 0.97). Fast-track patients had significantly shorter times to extubation (75 min [45-110] vs. 900 min [600-1140]), as well as shorter lengths of stay in the postanesthetic or intensive care unit (4 h [3.0-5] vs. 20 h [16-25]), intermediate care unit (21 h [17-39] vs. 26 h [19-49]), and hospital (10 days [8-12] vs. 11 days [9-14]) (expressed as median and interquartile range, all P operations.

6-Bromo-1,3-di-2-propynyl-1H-imidazo[4,5-b]pyridin-2(3H-one

Directory of Open Access Journals (Sweden)

S. Dahmani

2010-04-01

Full Text Available The room-temperature reaction of propargyl bromide and 6-bromo-1,3-dihydroimidazo[4,5-b]pyridin-2-one in dimethylformamide yields the title compound, C12H8BrN3O, which features nitrogen-bound propynyl substituents. The imidazopyridine fused ring is almost planar (r.m.s. deviation = 0.011 Å; the propynyl chains point in opposite directions relative to the fused ring. One acetylenic H atom is hydrogen bonded to the carbonyl O atom of an inversion-related molecule, forming a dimer; adjacent dimers are linked by a second acetylene–pyridine C—H...N interaction, forming a layer motif.

Evaluation of Perry Nuclear Power Plant Unit 1 technical specifications

International Nuclear Information System (INIS)

Baxter, D.E.; Bruske, S.J.

1985-11-01

This document was prepared for the Nuclear Regulatory Commission (NRC) to assist them in determining whether the Perry Nuclear Power Plant Unit 1 Technical Specifications (T/S), which govern plant systems configurations and operations, are in conformance with the requirements of the Final Safety Analysis Report (FSAR) as amended, and the requirements of the Safety Evaluation Report (SER) as supplemented. A comparative audit of the FSAR as amended, and the SER as supplemented was performed with the Perry T/S. Several discrepancies were identified and subsequently resolved through telephone conversations with the staff reviewer and the utility representative. Pending completion of the resolutions noted in Parts 3 and 4 of this report, the Perry Nuclear Power Plant Unit 1 T/S, to the extent reviewed, are in conformance with the FSAR and SER

HPV DNA methylation at the early promoter and E1/E2 integrity: A comparison between HPV16, HPV18 and HPV45 in cervical cancer.

Science.gov (United States)

Amaro-Filho, Sérgio Menezes; Pereira Chaves, Cláudia Bessa; Felix, Shayany Pinto; Basto, Diogo Lisbôa; de Almeida, Liz Maria; Moreira, Miguel Angelo Martins

2018-04-09

To compare and describe type-specific characteristics of HPV16, HPV18 and HPV45 in cervical cancer with respect to 3'LCR methylation and disruption of E1/E2. The methylation level of 137 cervical cancer samples (70 with HPV16, 37 with HPV18, and 30 with HPV45) of Brazilian patients was analyzed by pyrosequencing. PCR amplifications were performed to characterize E1 and E2 disruption as an episomal surrogate. The 3'LCR of HPV16 showed a higher methylation at all CpG sites (7%, 9%, 11%, 10% and 10%) than homologous HPV18 regions (4%, 5%. 6%, 9% and 5%) and HPV45 regions (7%, 7% and 5%). Presence of intact E1/E2 was associated with higher HPV16 and HPV18 methylation levels at all CpG sites (p < 0.05). Disruption of E1/E2 was more frequently found in HPV45 (97%) and HPV18 (84%) than in HPV16 DNA (30%). HPV16 disruption was more frequently found in E1 (48%) unlike HPV18, where it was found in E2 (61%). Concomitant disruption of E1/E2 was most frequent in HPV45 (72%). The findings showed a higher methylation associated with intact E1/E2 for HPV16 and HPV18. The closely phylogenetic related HPV18 and HPV45 share a similar methylation level and the frequency of viral genome disruption. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

Cold weather effects on Dresden Unit 1

Energy Technology Data Exchange (ETDEWEB)

Anagnostopoulos, H. [Commonwealth Edison Co., Morris, IL (United States)

1995-03-01

Dresden Unit 1 is in the final stages of a decommissioning effort directed at preparing the unit to enter a SAFSTOR status. Following an extended sub-zero cold wave, about 55,000 gallons of water were discovered in the lowest elevation of the spherical reactor enclosure. Cold weather had caused the freezing and breaking of several service water lines that had not been completely isolated. Two days later, at a regularly scheduled decommissioning meeting, the event was communicated to the decommissioning team, who quickly recognized the potential for freezing of a 42 inches diameter Fuel Transfer Tube that connects the sphere to the Spent Fuel Pool. The team directed that the pool gates between the adjacent Spent Fuel Pool and the Fuel Transfer Pool be installed, and a portable source of heat was installed on the Fuel Transfer Tube. It was later determined that, with the fuel pool gates removed, and with a worst case freeze break at the 502 elevation on the Fuel Transfer Tube (in the Sphere), the fuel in the Spent Fuel Pool could be uncovered to a level 3 below the top of active fuel.

11 th fuel reload of the Unit 1, leadership with results

International Nuclear Information System (INIS)

Serrano, R.H.

2006-01-01

At the moment the companies with world class, the formation of intellectual capital is a strategy to reach the excellence; the Management of Nucleo electric Centrals (GCN), aware of this strategy to achieve the mission commended, it establishes that it is decisive the leadership among their collaborators for the achievement of the goals. The obtained results in the 11 th reload of the Unit 1 are a sample of as how the leaders and collaborators when making work in team they have achieved the best results (collective dose and reload duration), until today in what is the history of the commercial operation of the Unit 1. (Author)

Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 involves active DNA demethylation by Gadd45-NER pathway.

Science.gov (United States)

Rajput, Pallavi; Pandey, Vijaya; Kumar, Vijay

2016-08-01

The well-studied Pol II transcription factor Sp1 has not been investigated for its regulatory role in rDNA transcription. Here, we show that Sp1 bound to specific sites on rDNA and localized into the nucleoli during the G1 phase of cell cycle to activate rDNA transcription. It facilitated the recruitment of Pol I pre-initiation complex and impeded the binding of nucleolar remodeling complex (NoRC) to rDNA resulting in the formation of euchromatin active state. More importantly, Sp1 also orchestrated the site-specific binding of Gadd45a-nucleotide excision repair (NER) complex resulting in active demethylation and transcriptional activation of rDNA. Interestingly, knockdown of Sp1 impaired rDNA transcription due to reduced engagement of the Gadd45a-NER complex and hypermethylation of rDNA. Thus, the present study unveils a novel role of Sp1 in rDNA transcription involving promoter demethylation. Copyright © 2016 Elsevier B.V. All rights reserved.

Associations among unit leadership and unit climates for implementation in acute care: a cross-sectional study.

Science.gov (United States)

Shuman, Clayton J; Liu, Xuefeng; Aebersold, Michelle L; Tschannen, Dana; Banaszak-Holl, Jane; Titler, Marita G

2018-04-25

Nurse managers have a pivotal role in fostering unit climates supportive of implementing evidence-based practices (EBPs) in care delivery. EBP leadership behaviors and competencies of nurse managers and their impact on practice climates are widely overlooked in implementation science. The purpose of this study was to examine the contributions of nurse manager EBP leadership behaviors and nurse manager EBP competencies in explaining unit climates for EBP implementation in adult medical-surgical units. A multi-site, multi-unit cross-sectional research design was used to recruit the sample of 24 nurse managers and 553 randomly selected staff nurses from 24 adult medical-surgical units from 7 acute care hospitals in the Northeast and Midwestern USA. Staff nurse perceptions of nurse manager EBP leadership behaviors and unit climates for EBP implementation were measured using the Implementation Leadership Scale and Implementation Climate Scale, respectively. EBP competencies of nurse managers were measured using the Nurse Manager EBP Competency Scale. Participants were emailed a link to an electronic questionnaire and asked to respond within 1 month. The contributions of nurse manager EBP leadership behaviors and competencies in explaining unit climates for EBP implementation were estimated using mixed-effects models controlling for nurse education and years of experience on current unit and accounting for the variability across hospitals and units. Significance level was set at α < .05. Two hundred sixty-four staff nurses and 22 nurse managers were included in the final sample, representing 22 units in 7 hospitals. Nurse manager EBP leadership behaviors (p < .001) and EBP competency (p = .008) explained 52.4% of marginal variance in unit climate for EBP implementation. Leadership behaviors uniquely explained 45.2% variance. The variance accounted for by the random intercepts for hospitals and units (p < .001) and years of nursing experience in current unit

44 CFR 208.45 - Advance of funds.

Science.gov (United States)

2010-10-01

... Agreements § 208.45 Advance of funds. At the time of Activation of a Task Force, the Task Force will develop... advance of funds will not include any costs for equipment purchase. ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Advance of funds. 208.45...

100-BC-1 Operable Unit focused feasibility study

International Nuclear Information System (INIS)

Day, R.E.

1994-01-01

The standard Comprehensive Environmental Response, Compensation, and Liability Act feasibility study includes development and screening of alternatives (Phases 1 and 2) and the detailed analysis of alternatives (Phase 3). This focused feasibility study constitutes the Phase 3 portion of the feasibility study process for the remedial alternatives initially developed and screened in the 100 Area Feasibility Study Phases 1 and 2 (DOE-RL 1993a). The focused feasibility study process is conducted in two stages, a Process Document (DOE-RL 1994a) and an operable unit-specific focused feasibility study document, such as this one. The focused feasibility study process is performed by implementing a ''plug-in'' style approach; as defined in greater detail in the Process Document, which is a companion to this document. The objective of this focused feasibility study is to provide decision makers with sufficient information to allow appropriate and timely selection of interim remedial measures for candidate waste sites associated with the 100-BC-1 Operable Unit which is located in the north-central part of the Hanford Site. The interim remedial measure candidate waste sites are determined in the Limited Field Investigation (DOE-RL 1993b). Site profiles are developed for each of these waste sites. The site profiles are used in the application of the plug-in approach. The waste site either plugs into the analysis of the alternatives for the group, or deviations from the developed group alternatives are described and documented

Geriatric patient profile in the cardiovascular surgery intensive care unit

International Nuclear Information System (INIS)

Korha, E.A.; Hakverdioglu, G.; Ozlem, M.; Yurekli, I.; Gurbuz, A.; Alp, N.A

2013-01-01

Objectives: To determine hospitalization durations and mortalities of elderly in the Cardiovascular Surgery Intensive Care Unit. Methods: The retrospective study was conducted in a Cardiovascular Surgery Intensive Care Unit in Turkey and comprised patient records from January 1 to December 31, 2011. Computerized epicrisis reports of 255, who had undergone a cardiac surgery were collected. The patients were grouped according to their ages, Group I aged 65-74 and Group II aged 75 and older. European society for Cardiac Operative Risk Evaluation scores of the two groups were compared using SPSS 17. Results: Overall, there were 80 (31.37%) females and 175 (68.62%) males. There were 138 (54.1%) patients in Group I and 117 (45.9%) in Group II. Regarding their hospitalization reasons, it was determined that 70 (27.5%) patients in Group I and 79 (30.9%) patients in Group II were treated with the diagnosis of coronary artery disease. The average hospitalization duration of patients in the intensive care unit was determined to be 11.57+-10.40 days. Regarding the EuroSCORE score intervals of patients, 132 (51.8%)had 3-5 and 225 (88.2%) patients were transferred to the Cardiovascular Surgery and then all of them were discharged; 5 (4.1%) had a mortal course; and 11 (7.7%) were transferred to the anaesthesia intensive care unit Conclusions: The general mortality rates are very low in the Cardiovascular Surgery Intensive Care Unit and the patients have a good prognosis. (author)

Geriatric patient profile in the cardiovascular surgery intensive care unit.

Science.gov (United States)

Korhan, Esra Akin; Hakverdioglu, Gulendam; Ozlem, Maryem; Ozlem, Maryem; Yurekli, Ismail; Gurbuz, Ali; Alp, Nilgun Akalin

2013-11-01

To determine hospitalization durations and mortalities of elderly in the Cardiovascular Surgery Intensive Care Unit. The retrospective study was conducted in a Cardiovascular Surgery Intensive Care Unit in Turkey and comprised patient records from January 1 to December 31, 2011. Computerized epicrisis reports of 255, who had undergone a cardiac surgery were collected. The patients were grouped according to their ages, Group I aged 65-74 and Group II aged 75 and older. European society for Cardiac Operative Risk Evaluation scores of the two groups were compared using SPSS 17. Overall, there were 80 (31.37%) females and 175 (68.62%) males. There were 138 (54.1%) patients in Group I and 117 (45.9%) in Group II. Regarding their hospitalization reasons, it was determined that 70 (27.5%) patients in Group I and 79 (30.9%) patients in Group II were treated with the diagnosis ofcoronary artery disease. The average hospitalization duration of patients in the intensive care unit was determined to be 11.57 +/- 0.40 days. Regarding the EuroSCORE score intervals of patients, 132 (51.8%) had 3-5 and 225 (88.2%) patients were transferred to the Cardiovascular Surgery and then all of them were discharged; 5 (4.1%) had a mortal course; and 11 (7.7%) were transferred to the anaesthesia intensive care unit. The general mortality rates are very low in the Cardiovascular Surgery Intensive Care Unit and the patients have a good prognosis.

Browns Ferry Nuclear Power Station, Units 1, 2, and 3. Annual operating report: January--December 1976

International Nuclear Information System (INIS)

1977-01-01

Units 1 and 2 were down for the first half of the year caused by the fire of March 1975. Net electrical power generated by Unit 1 this year was 1,301,183 MWH with the generator on line 2,175.25 hrs. Unit 2 generated 1,567,170 MWH with the generator on line 2,548.73 hrs. Unit 3 began full power operation on November 20th and generated 1,416,891 MWH with the generator on line 2,058.20 hrs. Information is presented concerning operations, fuel performance, surveillance testing, containment leak testing, changes, power generation, shutdown and forced reductions, coolant chemistry, occupational radiation exposures, and maintenance

Cernavoda NPP Unit 1 - a plant of several generations

International Nuclear Information System (INIS)

Rotaru, I.; Metes, M.; Anghelescu, M.S.

2001-01-01

The paper reflects some key aspects related to the shift of generations during the project's development, including the present stage. Further, the place of Cernavoda NPP Unit 1 in the Romanian power sector and among other nuclear stations in the world is presented. The operational performances achieved 'in service' up to the end of 1999, with reference to the performance indicators for electrical energy production, nuclear safety, radiation protection, radioactive wastes and nuclear fuel are illustrated. For all of these items, comparisons are performed with similar indicators reported by other worldwide nuclear power plants, in order to assess our results. Finally, some comments about Cernavoda NPP Unit 2 project status and need to completion and commissioning it are included. (authors)

Evaluation of power commissioning of the Mochovce Unit 1 demonstration run

International Nuclear Information System (INIS)

Sarvaic, I.; Miskolci, M.

1998-01-01

The document contains evaluation of the 144 hour demonstration run of the Mochovce Unit 1. In the document, the courses and results of additional tests in this phase of power commissioning are summarized, evaluation of the performance of important systems and equipment of the unit is carried out, as well as of the compliance with Limits and Conditions in the course of the demonstration run. On this basis, conclusions are drawn and recommendations given for the unit to by ready for trial operation. The evaluation was developed by the scientific management of the Mochovce commissioning providing an independent support for the operators for supervising the commissioning tasks from the point of nuclear safety

Assembly of disperse red 1 molecules in the channels of AlPO4-5 single crystals for second-harmonic generation

NARCIS (Netherlands)

Jiang, FY; Lu, WX; Zhai, JP; Ye, JT; Wong, GKL; Han, Xueyao; Tang, ZK

2006-01-01

Disperse red 1 (DR1) molecules have been successfully incorporated into the one-dimensional channels of AlPO4-5 single crystals by means of vapor-phase diffusion. Polarizing microscope and SHG results indicate that the DR1 molecules are well aligned in a preferred direction along the crystal

Attributes for NHDPlus Catchments (Version 1.1) in the Conterminous United States: Artificial Drainage (1992) and Irrigation Types (1997)

Science.gov (United States)

Wieczorek, Michael; LaMotte, Andrew E.

2010-01-01

This tabular dataset represents the estimated area of artificial drainage for the year 1992 and irrigation types for the year 1997 compiled for every catchment of NHDPlus for the conterminous United States. The source datasets were derived from tabular National Resource Inventory (NRI) datasets created by the National Resources Conservation Service (NRCS, U.S. Department of Agriculture, 1995, 1997). Artificial drainage is defined as subsurface drains and ditches. Irrigation types are defined as gravity and pressure. Subsurface drains are described as conduits, such as corrugated plastic tubing, tile, or pipe, installed beneath the ground surface to collect and/or convey drainage. Surface drainage field ditches are described as graded ditches for collecting excess water. Gravity irrigation source is described as irrigation delivered to the farm and/or field by canals or pipelines open to the atmosphere; and water is distributed by the force of gravity down the field by: (1) A surface irrigation system (border, basin, furrow, corrugation, wild flooding, etc.) or (2) Sub-surface irrigation pipelines or ditches. Pressure irrigation source is described as irrigation delivered to the farm and/or field in pump or elevation-induced pressure pipelines, and water is distributed across the field by: (1) Sprinkle irrigation (center pivot, linear move, traveling gun, side roll, hand move, big gun, or fixed set sprinklers), or (2) Micro irrigation (drip emitters, continuous tube bubblers, micro spray or micro sprinklers). NRI data do not include Federal lands and are thus excluded from this dataset. The tabular data for drainage were spatially apportioned to the National Land Cover Dataset (NLCD, Kerie Hitt, written commun., 2005) and the tabular data for irrigation were spatially apportioned to an enhanced version of the National Land Cover Dataset (NLCDe, Nakagaki and others 2007) The NHDPlus Version 1.1 is an integrated suite of application-ready geospatial datasets that

Bibliography on Cold Regions Science and Technology, Volume 45, Part 2

Science.gov (United States)

1991-12-01

fluorine in the Par North p. 1148-I115 1, eng] 45-263 Bets radiation from snow t1990, p.23, engi 45-919 t1 9 8 9 , p.95-100, rus] 45-739 182 CRREL...A.S. quential Landiat images t1 990 , p.105-106, eng]FiD. Pollution of the environment by fluorine in the Far North 45-13%4 Laboratory comparison of...ugyAaa mutiig ;ellaitly. A.F. 4-40 Vrain ngaito fteKne ltumuti ig Ferromanganese rock varnish in North Norway: a subglacial Gleekx, R.E under possible

A rare case of mixed gonadal dysgenesis: 45, X0/ 46, X, +mar 1/ 46, X, +mar 2

Directory of Open Access Journals (Sweden)

Carolina Talini

2016-07-01

Full Text Available This study aims to report a rare case of mixed gonadal dysgenesis with mosaicism pattern 45 X0 / 46, X, +mar 1/ 46, X, +mar 2. Patient referred to the pediatric urology service with 2 months of age. Right after the baby was born it was not possible do determine the baby's gender. The karyotype was inconclusive: 45, X0. Contrast genitography and uretrocystogram showed a single perineal orifice below the micropenis and between the bifid scrotum, opacification of the bladder with male aspect urethra during urination and short penile urethra. There was also opacification of the posterior vaginal cavity with low junction to the posterior urethra and a linear opacity image suggesting uterine canal. Laparoscopy revealed bilateral gonadal bands and spermatic elements entering the inguinal canal. Müllerian derivatives were absent. Gonadal biopsy was performed and concluded that these were abnormal infantile testes. Microarray testing took a few months and resulted in: 45 X0 / 46, X, +mar 1/ 46, X, +mar 2. Patient was kept on topic androstenedione for 6 months and then underwent penoscrotal hypospadias correction. Mosaic chromosomal pattern is a rare condition that can present with a wide variety of phenotypes. Early recognition has important implications on these patients’ social and psychological life and also for their proper management.

Neutron embrittlement of the Kozloduy NPP unit 1 reactor

International Nuclear Information System (INIS)

Vodenicharov, S.; Kamenova, Tz.

1996-01-01

Activities made in the period 1989-1996 according to the Program for metal state monitoring of the Kozloduy NPP Unit 1 are described. Data on P and Cu content in the welded joint 4 are reported. Determination is made by wet chemical analysis of shavings taken out from the inner side of the wall, direct spectral analysis of the vessel itself and spectroscopy of the inner and outer side of 6 templates. The results obtained from 4 different study teams showed a good agreement. The real average P content is 0.046% and tends to diminish in depth. Microstructural investigation does not show any expressed inter-crystalline mechanism of brittle failure at low temperatures. The data on real P and Cu content, as well as the experimental values of the initial critical temperature of embrittlement (Tk o ), the residual part of temperature shift (Tk r ) and the re-embrittlement temperature after annealing at 475 o (Tk) allow to predict the change in Tk o of the joint 4 during the next refueling cycles. The measured low value of Tk after 18-th refueling cycle is considerably lower than that forecasted by lateral re-embrittlement law. This means that the forecasting of Tk for the next cycles is made with big enough conservatisms, and that a second annealing of the vessel until 26-th cycle is not necessary. So according to the most conservative estimate, the Unit 1 can operate safely until the end of the 26-th refueling cycle. It is also concluded, that in terms of radiation degradation of the vessel metal the operation life time of the Unit 1 can reach and exceed the designed one. 2 tab., 7 ref

Calculation of the real states of Ignalina NPP Unit 1 and Unit 2 RBMK-1500 reactors in the verification process of QUABOX/CUBBOX code

International Nuclear Information System (INIS)

Bubelis, E.; Pabarcius, R.; Demcenko, M.

2001-01-01

Calculations of the main neutron-physical characteristics of RBMK-1500 reactors of Ignalina NPP Unit 1 and Unit 2 were performed, taking real reactor core states as the basis for these calculations. Comparison of the calculation results, obtained using QUABOX/CUBBOX code, with experimental data and the calculation results, obtained using STEPAN code, showed that all the main neutron-physical characteristics of the reactors of Unit 1 and Unit 2 of Ignalina NPP are in the safe deviation range of die analyzed parameters, and that reactors of Ignalina NPP, during the process of the reactor core composition change, are operated in a safe and stable manner. (author)

Soil washing physical separations test procedure - 300-FF-1 operable unit

Energy Technology Data Exchange (ETDEWEB)

Belden, R.D.

1993-10-08

This procedure provides the operations approach, a field sampling plan, and laboratory procedures for a soil washing test to be conducted by Alternative Remedial Technologies, Inc. (ART) in the 300-FF-1 area at the Hanford site. The {open_quotes}Quality Assurance Project Plan for the Soil Washing Physical Separations Test, 300-FF-1 Operable Unit,{close_quotes} Hanford, Washington, Alternative Remedial Technologies, Inc., February 1994 (QAPP) is provided in a separate document that presents the procedural and organizational guidelines for this test. This document describes specifications, responsibilities, and general procedures to be followed to conduct physical separation soil treatability tests in the North Process Pond of the 300-FF-1 Operable Unit (OU) at the Hanford Site. These procedures are based on the {open_quotes}300-FF-1 Physical Separations CERCLA Treatability Test Plan, DOE/RL 92-2l,{close_quotes} (DOE-RL 1993).

Soil washing physical separations test procedure - 300-FF-1 operable unit

International Nuclear Information System (INIS)

Belden, R.D.

1993-01-01

This procedure provides the operations approach, a field sampling plan, and laboratory procedures for a soil washing test to be conducted by Alternative Remedial Technologies, Inc. (ART) in the 300-FF-1 area at the Hanford site. The open-quotes Quality Assurance Project Plan for the Soil Washing Physical Separations Test, 300-FF-1 Operable Unit,close quotes Hanford, Washington, Alternative Remedial Technologies, Inc., February 1994 (QAPP) is provided in a separate document that presents the procedural and organizational guidelines for this test. This document describes specifications, responsibilities, and general procedures to be followed to conduct physical separation soil treatability tests in the North Process Pond of the 300-FF-1 Operable Unit (OU) at the Hanford Site. These procedures are based on the open-quotes 300-FF-1 Physical Separations CERCLA Treatability Test Plan, DOE/RL 92-2l,close quotes (DOE-RL 1993)

45 CFR 86.51 - Employment.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Employment. 86.51 Section 86.51 Public Welfare... in Employment in Education Programs or Activities Prohibited § 86.51 Employment. (a) General. (1) No... subjected to discrimination in employment, or recruitment, consideration, or selection therefor, whether...

Inventory of power plants in the United States as of January 1, 1998

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-01

The Inventory of Power Plants in the United States provides annual statistics on generating units operated by electric utilities in the US (the 50 States and the District of Columbia). Statistics presented in this report reflect the status of generating units as of January 1, 1998. The publication also provides a 10-year outlook for generating unit additions and generating unit changes. This report is prepared annually by the Energy Information Administration (EIA). Data summarized in this report are useful to a wide audience. This is a report of electric utility data; in cases where summary data or nonconfidential data of nonutilities are presented, it is specifically noted as nonutility data. 19 figs., 36 tabs.

20 CFR 401.45 - Verifying your identity.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Verifying your identity. 401.45 Section 401... INFORMATION The Privacy Act § 401.45 Verifying your identity. (a) When required. Unless you are making a... representative, you must verify your identity in accordance with paragraph (b) of this section if: (1) You make a...

75 FR 8757 - Nebraska Public Power District, Cooper Nuclear Station, Unit 1; Notice of Availability of the...

Science.gov (United States)

2010-02-25

..., Cooper Nuclear Station, Unit 1; Notice of Availability of the Draft Supplement 41 to the Generic... Renewal of Cooper Nuclear Station, Unit 1 Notice is hereby given that the U.S. Nuclear Regulatory... operating license DPR-46 for an additional 20 years of operation for Cooper Nuclear Station, Unit 1 (CNS-1...

Synthesis of Schiff and Mannich Bases of Isatin Derivatives with 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones

Directory of Open Access Journals (Sweden)

Hakan Bektas

2008-09-01

Full Text Available Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were synthesized by reacting with formaldehyde and piperidine. Their chemical structures were confirmed by means of IR, 1H- and 13C-NMR data and by elemental analysis.

Tectolinear interpretation of a 1:5,000,000 Landsat-1 mosaic compared with the structure of central and eastern United States

Science.gov (United States)

Kutina, Jan; Carter, William D.

1978-01-01

The pattern of lineaments and curvilinear features interpreted from a 1:5,000,000 mosaic of satellite images (Landsat-1 was superimposed on a simplified version of the Geological Map of the United States, 1:2,500,000 scale, showing the structural scheme of Central and Eastern United States. A comparison of the above two patterns, shown in Fig. 1, is presented in this paper.

Activities of the Entomology Unit. Report No. 1, 1987

International Nuclear Information System (INIS)

1987-06-01

This semi-annual report describes the activities carried out by the staff of the Entomology Unit at the Agency's Laboratories, Seibersdorf, between 1 January and 30 June 1987. This report includes preliminary results of research not sufficiently complete to justify general release. Such findings, when adequately confirmed will be released through established channels. Figs and tabs

Pilot-scale treatability test plan for the 200-UP-1 groundwater Operable Unit

International Nuclear Information System (INIS)

Wittreich, C.D.

1994-05-01

This document presents the treatability test plan for pilot-scale pump and treat testing at the 200-UP-1 Operable Unit. This treatability test plan has been prepared in response to an agreement between the US Department of Energy, the US Environmental Protection Agency, and the Washington State Department of Ecology, as documented in Hanford Federal Facility Agreement and Consent Order (Ecology et al. 1989a) Change Control Form M-13-93-03 (Ecology et al. 1994). The agreement also requires that, following completion of the activities described in this test plan, a 200-UP-1 Operable Unit interim remedial measure (IRM) proposed plan be developed for use in preparing an interim action record of decision (ROD). The IRM Proposed Plan will be supported by the results of the testing described in this treatability test plan, as well as by other 200-UP-1 Operable Unit activities (e.g., limited field investigation, development of a qualitative risk assessment). Once issued, the interim action ROD will specify the interim action for groundwater contamination at the 200-UP-1 Operable Unit. The approach discussed in this treatability test plan is to conduct a pilot-scale pump and treat test for the contaminant plume associated with the 200-UP-1 Operable Unit. Primary contaminants of concern are uranium and technetium-99; the secondary contaminant of concern is nitrate. The pilot-scale treatability testing presented in this test plan has as its primary purpose to assess the performance of aboveground treatment systems with respect to the ability to remove the primary contaminants in groundwater withdrawn from the contaminant plume

Development of the MARS input model for Kori nuclear units 1 transient analyzer

International Nuclear Information System (INIS)

Hwang, M.; Kim, K. D.; Lee, S. W.; Lee, Y. J.; Lee, W. J.; Chung, B. D.; Jeong, J. J.

2004-11-01

KAERI has been developing the 'NSSS transient analyzer' based on best-estimate codes for Kori Nuclear Units 1 plants. The MARS and RETRAN codes have been used as the best-estimate codes for the NSSS transient analyzer. Among these codes, the MARS code is adopted for realistic analysis of small- and large-break loss-of-coolant accidents, of which break size is greater than 2 inch diameter. So it is necessary to develop the MARS input model for Kori Nuclear Units 1 plants. This report includes the input model (hydrodynamic component and heat structure models) requirements and the calculation note for the MARS input data generation for Kori Nuclear Units 1 plant analyzer (see the Appendix). In order to confirm the validity of the input data, we performed the calculations for a steady state at 100 % power operation condition and a double-ended cold leg break LOCA. The results of the steady-state calculation agree well with the design data. The results of the LOCA calculation seem to be reasonable and consistent with those of other best-estimate calculations. Therefore, the MARS input data can be used as a base input deck for the MARS transient analyzer for Kori Nuclear Units 1

Remedial investigation for the 200-BP-1 operable unit, Hanford Site, Richland, Washington

International Nuclear Information System (INIS)

Buckmaster, M.A.

1991-01-01

The Hanford Site, Richland, Washington, contains over 1500 identified waste sites that will be characterized and remediated over the next 30 years. In support of the ''Hanford Federal Facility Agreement and Consent Order,'' the US Department of Energy has initiated a remedial investigation/feasibility study (RI/FS) at the 200-BP-1 operable unit. The 200-BP-1 RI is the first Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) investigation on the Hanford Site that involves drilling into highly radioactive and chemically contaminated soils. The initial phase of the site characterization is oriented toward determining the nature and extent of any contamination present in the vicinity of the 200-BP-1 operable unit. The major focus of the Phase I RI is the drilling and sampling of 10 inactive waste disposal units which received low level radioactive liquid waste

19 CFR 18.45 - Supervision of exportation.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Supervision of exportation. 18.45 Section 18.45 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Merchandise Not Otherwise Subject to Customs Control Exported Under Cover of A Tir Carnet ...

Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle

DEFF Research Database (Denmark)

Nielsen, Jens Steen; Rode, Frederik; Rahbek, Mette

2011-01-01

• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced by electri......• To investigate the importance of small (SK)- and intermediate (IK)-conductance Ca2(+) -activated K(+) channels on bladder function, by studying the effects of 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), a new modulator of SK/IK channels, on contractions induced...

Crystallisation kinetics of amorphous Fe72.5-xCu1Nb4.5Si10+x+yB12-y alloy

International Nuclear Information System (INIS)

Miglierini, M.; Lipka, J.; Sitek, J.

1994-01-01

Fe 73.5 Cu 1 Nb 3 Si 13.5 B 9 and Fe 72.5-x Cu 1 Nb 4.5 Si 10+x+y B 12-y alloys are compared from the point of view of crystallisation behaviour and changes in the short-range order in the amorphous reminder. The increase in Nb to 4.5 at.% in the latter system slows down the formation of nanocrystals to approximately 40% even after 16 hours of anneal at 550 C for x = 0.5, y = 3. Segregation-induced changes in the short-range order are manifested via hyperfine field distributions corresponding to the amorphous reminder. (orig.)

Cloning, expression and preliminary crystallographic analysis of the equine infectious anaemia virus (EIAV) gp45 ectodomain

International Nuclear Information System (INIS)

Sun, Pei-Long; Lv, Shu-Xia; Zhou, Jian-Hua; Liu, Xin-Qi

2011-01-01

The equine infectious anaemia virus gp45 ectodomain was cloned, expressed and crystallized. Preliminary crystallographic analysis showed that the protein belonged to space group P6 3 and contained one molecule per asymmetric unit. Like human immunodeficiency virus (HIV), equine infectious anaemia virus (EIAV) belongs to the lentivirus genus. The first successful lentiviral vaccine was developed for EIAV. Thus, EIAV may serve as a valuable model for HIV vaccine research. EIAV glycoprotein 45 (gp45) plays a similar role to gp41 in HIV by mediating virus–host membrane fusion. The gp45 ectodomain was constructed according to the structure of HIV gp41, with removal of the disulfide-bond loop region. The protein was expressed in Escherichia coli and crystallized following purification. However, most of the crystals grew as aggregates and could not be used for data collection. By extensively screening hundreds of crystals, a 2.7 Å resolution data set was collected from a single crystal. The crystal belonged to space group P6 3 , with unit-cell parameters a = b = 46.84, c = 101.61 Å, α = β = 90, γ = 120°. Molecular replacement was performed using the coordinates of various lengths of HIV gp41 as search models. A long bent helix was identified and a well defined electron-density map around the long helix was obtained. This primary model provided the starting point for further refinement

Anti-irradiation performance against helium bombardment in bulk metallic glass (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5}

Energy Technology Data Exchange (ETDEWEB)

Mei, Xianxiu, E-mail: xxmei@dlut.edu.cn [Key Laboratory of Materials Modification by Laser, Ion and Electron Beams, Dalian University of Technology, Ministry of Education, Dalian 116024 (China); Wang, Bin; Dong, Chuang; Gong, Faquan; Wang, Younian [Key Laboratory of Materials Modification by Laser, Ion and Electron Beams, Dalian University of Technology, Ministry of Education, Dalian 116024 (China); Wang, Zhiguang [Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000 (China)

2013-07-15

Highlights: ► This paper used He{sup 2+} ion-irradiated metallic glass (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5} and the W metal with the energy of 500 keV. ► There was no significant irradiation damage phenomenon on the surface of metallic glass at different irradiation fluences. ► For irradiated W, the peeling, delamination and flaking appeared numerously at fluences of 1 × 10{sup 18} and 2 × 10{sup 18} ions/cm{sup 2}. ► The resistance to He{sup 2+} irradiation of metallic glass (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5} was superior to the one in W metal. -- Abstract: In order to compare the resistance to He{sup 2+} ion induced irradiation between metallic glass and polycrystal W metal, this paper used different fluences of He{sup 2+} ion-irradiated metallic glass (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5} and polycrystal W with an energy of 500 keV. The SRIM simulation calculation results showed that the range (1.19 μm) of He{sup 2+} in metallic glass was greater than the one (0.76 μm) in polycrystal W. The SEM analysis showed that there was no significant irradiation damage phenomenon on the surface of metallic glass, and there was only a damage layer 1.45 μm away from the surface when the fluence reached 2 × 10{sup 18} ions/cm{sup 2}. For W, there were surface peeling, flaking and other surface damages at a fluence of 1 × 10{sup 18} ions/cm{sup 2}; when the fluence increased to 2 × 10{sup 18} ions/cm{sup 2}, multilayer detachment phenomenon appeared. The surface root mean square roughness of metallic glass (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5} first increased and then decreased with the increase of fluence. The surface reflectivity of (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5} decreased with the increase of fluence. Through detection by XRD, it was found that (Cu{sub 47}Zr{sub 45}Al{sub 8}){sub 98.5}Y{sub 1.5} always maintained amorphous phase after different fluences of radiation. The

Plasma membrane associated phospholipase C from human platelets: Synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5'-O-(3-thiotriphosphate)

International Nuclear Information System (INIS)

Baldassare, J.J.; Henderson, P.A.; Fisher, G.J.

1989-01-01

The effects of thrombin and GTPγS on the hydrolysis of phosphoinositides by membrane-associated phospholipase C (PLC) from human platelets were examined with endogenous [ 3 H]inositol-labeled membranes or with lipid vesicles containing either [ 3 H]phosphatidylinositol or [ 3 H]phosphatidylinositol 4,5-bisphosphate. GTPγS (1 μM) or thrombin (1 unit/mL) did not stimulate release of inositol trisphosphate (IP 3 ), inositol bisphosphate (IP 2 ), or inositol phosphate (IP) from [ 3 H]inositol-labeled membranes. IP 2 and IP 3 , but not IP, from [ 3 H]inositol-labeled membranes were, however, stimulated 3-fold by GTPγS (1 μM) plus thrombin (1 unit/mL). A higher concentration of GTPγS (100 μM) alone also stimulated IP 2 and IP 3 , but not IP, release. In the presence of 1 mM calcium, release of IP 2 and IP 3 was increased 6-fold over basal levels; however, formation of IP was not observed. At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP 2 ) by platelet membrane associated PLC was also markedly enhanced by GTPγS (100 μM) or GTPγS (1 μM) plus thrombin (1 unit/mL). Under identical conditions, exogenous phosphatidylinositol (PI) was not hydrolyzed. The same substrate specificity was observed when the membrane-associated PLC was activated with 1 mM calcium. Thrombin-induced hydrolysis of PIP 2 was inhibited by treatment of the membranes with pertussis toxin or pretreatment of intact platelets with 12-O-tetradecanoyl-13-acetate (TPA) prior to preparation of membranes. Pertussis toxin did not inhibit GTPγS (100 μM) or calcium (1 mM) dependent PIP 2 breakdown, while TPA inhibited GTPγS-dependent but not calcium-dependent phospholipase C activity

Quad-Cities Station, Units 1 and 2. Semiannual operating report, January--June 1975

International Nuclear Information System (INIS)

1975-01-01

Unit 1 generated 2,024,125 net electrical MWH and the generator was on line 3162.6 hours. Unit 2 generated 746,184 net electrical MWH and was on line 1475.3 hrs. Data is included concerning operations, power generation, shutdowns, maintenance, changes, and tests. (FS)

45 CFR 79.21 - Discovery.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Discovery. 79.21 Section 79.21 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.21 Discovery. (a) The following types of discovery are authorized: (1) Requests for production of documents for...

Nosocomial Pandemic (H1N1) 2009, United Kingdom, 2009–2010

Science.gov (United States)

Myles, Puja R.; Openshaw, Peter J.M.; Gadd, Elaine M.; Lim, Wei Shen; Semple, Malcolm G.; Read, Robert C.; Taylor, Bruce L.; McMenamin, James; Armstrong, Colin; Bannister, Barbara; Nicholson, Karl G.; Nguyen-Van-Tam, Jonathan S.

2011-01-01

To determine clinical characteristics of patients hospitalized in the United Kingdom with pandemic (H1N1) 2009, we studied 1,520 patients in 75 National Health Service hospitals. We characterized patients who acquired influenza nosocomially during the pandemic (H1N1) 2009 outbreak. Of 30 patients, 12 (80%) of 15 adults and 14 (93%) of 15 children had serious underlying illnesses. Only 12 (57%) of 21 patients who received antiviral therapy did so within 48 hours after symptom onset, but 53% needed escalated care or mechanical ventilation; 8 (27%) of 30 died. Despite national guidelines and standardized infection control procedures, nosocomial transmission remains a problem when influenza is prevalent. Health care workers should be routinely offered influenza vaccine, and vaccination should be prioritized for all patients at high risk. Staff should remain alert to the possibility of influenza in patients with complex clinical problems and be ready to institute antiviral therapy while awaiting diagnosis during influenza outbreaks. PMID:21470446

Point Beach Nuclear Plant, Units 1 and 2. Semiannual operating report No. 10, January--June 1975

International Nuclear Information System (INIS)

1975-01-01

Unit 1 operated at an average capacity factor of 65.2 percent with a net efficiency of 31.41 percent. Unit 2 operted at an average capacity factor of 88.6 lpercent with a net efficiency of 32.28 percent. Unit 1 was essentially base loaded while Unit 2 operated on load follow. Information is presented concerning power generation, shutdowns, corrective maintenance, chemistry and radiochemistry, occupational radiation exposure, release of radioactive materials, abnormal occurrences, and environmental monitoring. (FS)

Potential benefits of minimum unit pricing for alcohol versus a ban on below cost selling in England 2014: modelling study.

Science.gov (United States)

Brennan, Alan; Meng, Yang; Holmes, John; Hill-McManus, Daniel; Meier, Petra S

2014-09-30

To evaluate the potential impact of two alcohol control policies under consideration in England: banning below cost selling of alcohol and minimum unit pricing. Modelling study using the Sheffield Alcohol Policy Model version 2.5. England 2014-15. Adults and young people aged 16 or more, including subgroups of moderate, hazardous, and harmful drinkers. Policy to ban below cost selling, which means that the selling price to consumers could not be lower than tax payable on the product, compared with policies of minimum unit pricing at £0.40 (€0.57; $0.75), 45 p, and 50 p per unit (7.9 g/10 mL) of pure alcohol. Changes in mean consumption in terms of units of alcohol, drinkers' expenditure, and reductions in deaths, illnesses, admissions to hospital, and quality adjusted life years. The proportion of the market affected is a key driver of impact, with just 0.7% of all units estimated to be sold below the duty plus value added tax threshold implied by a ban on below cost selling, compared with 23.2% of units for a 45 p minimum unit price. Below cost selling is estimated to reduce harmful drinkers' mean annual consumption by just 0.08%, around 3 units per year, compared with 3.7% or 137 units per year for a 45 p minimum unit price (an approximately 45 times greater effect). The ban on below cost selling has a small effect on population health-saving an estimated 14 deaths and 500 admissions to hospital per annum. In contrast, a 45 p minimum unit price is estimated to save 624 deaths and 23,700 hospital admissions. Most of the harm reductions (for example, 89% of estimated deaths saved per annum) are estimated to occur in the 5.3% of people who are harmful drinkers. The ban on below cost selling, implemented in the England in May 2014, is estimated to have small effects on consumption and health harm. The previously announced policy of a minimum unit price, if set at expected levels between 40 p and 50 p per unit, is estimated to have an approximately 40-50 times

[Cloning of human CD45 gene and its expression in Hela cells].

Science.gov (United States)

Li, Jie; Xu, Tianyu; Wu, Lulin; Zhang, Liyun; Lu, Xiao; Zuo, Daming; Chen, Zhengliang

2015-11-01

To clone human CD45 gene PTPRC and establish Hela cells overexpressing recombinant human CD45 protein. The intact cDNA encoding human CD45 amplified using RT-PCR from the total RNA extracted from peripheral blood mononuclear cells (PBMCs) of a healthy donor was cloned into pMD-18T vector. The CD45 cDNA fragment amplified from the pMD-18T-CD45 by PCR was inserted to the coding region of the PcDNA3.1-3xflag vector, and the resultant recombinant expression vector PcDNA3.1-3xflag-CD45 was transfected into Hela cells. The expression of CD45 in Hela cells was detected by flow cytometry and Western blotting, and the phosphastase activity of CD45 was quantified using an alkaline phosphatase assay kit. The cDNA fragment of about 3 900 bp was amplified from human PBMCs and cloned into pMD-18T vector. The recombinant expression vector PcDNA3.1-3xflag-CD45 was constructed, whose restriction maps and sequence were consistent with those expected. The expression of CD45 in transfected Hela cells was detected by flow cytometry and Western blotting, and the expressed recombinant CD45 protein in Hela cells showed a phosphastase activity. The cDNA of human CD45 was successfully cloned and effectively expressed in Hela cells, which provides a basis for further exploration of the functions of CD45.

Redundant filtration system of the fuel buildings,units 1 and 2 Almaraz NPP

International Nuclear Information System (INIS)

Lopez Tanco, J.

2011-01-01

The project redundant filtering fuel buildings in units 1 and 2 of Almaraz NPP, will compliance to the requirements established in the complementary technical instructions to the authorization of exploitation of Almaraz NPP, established by the CSN and will consist of the installation of a new filtration unit.

The success of the 45th CERN Relay Race

CERN Multimedia

CERN Bulletin

2015-01-01

On Thursday, 21 May, 783 people (9 Nordic walkers and 129 teams of 6 runners each) took part in the 45th CERN Relay Race.   The teams were divided into eight different categories: three CERN categories (Seniors, Dames, Mixte) – in which the six runners in the team must belong to the same professional unit – and four “open” categories (Open, Veterans Open, Dames Open, Mixte Open) - in which the six runners in the team do not necessarily belong to the same professional unit and can include people from outside CERN. Each team covered 3,600 metres around the Meyrin site, with the race's fastest runners covering this distance in only 11 minutes and 5 seconds! (See all the results here. For more photos from the event, see here, here and here.)  

Early postischemic 45Ca accumulation in rat dentate hilus

International Nuclear Information System (INIS)

Benveniste, H.; Diemer, N.H.

1988-01-01

Several studies have found postischemic regional accumulation of calcium to be time-dependent and coincident with the progression of ischemic cell change. In the most vulnerable cells in the hippocampus one would therefore expect to find a primary and specific early uptake of calcium after ischemia. Autoradiograms of 45 Ca and 3 H-inulin distribution were investigated before and 1 h after 20 min ischemia in the rat hippocampus. Two different methodological approaches were used for administration of 45 Ca: (a) administration via microdialysis probes, (b) intraventricular injection. During control conditions the 45 Ca autoradiograms showed variations in distribution volume in accordance with 3 H-inulin determination of extracellular space size. One hour after ischemia a massive accumulation of 45 Ca was found in the dentate hilus. No change in the distribution pattern of 3 H-inulin could be demonstrated 1 h after ischemia. We suggest that 45 Ca accumulation in dentate hilus 1 h after ischemia is a result of increased Ca 2+ uptake before irreversible cell damage occurs and is not due to passive influx of calcium across a leaky plasma membrane

Search and Retrieval of Foreign Objects for the Steam Generator of Wolsung NPP Unit 1

Energy Technology Data Exchange (ETDEWEB)

Jeong, Woo-Tae; Lee, Kyung-Ho [KHNP CRI, Daejeon (Korea, Republic of)

2016-10-15

We developed a foreign object search and retrieval (FOSAR) system for Wolsung NPP unit 1 steam generators. The steam generators of Wolsung NPP unit 1 have one 2.5 inch hand hole and two 4 inch hand holes. The FOSAR system was designed to be installed through 4 inch hand holes. Using permanent magnet, the FOSAR system was firmly attached to the vertical annulus wall of the steam generator. We successfully developed the FOSAR system for Wolsung NPP unit 1. Using the developed FOSAR system, technicians successfully found and removed various foreign objects. Most of the foreign objects, we found, were made of carbon steel sheet, therefore magnet tool was the most useful to remove it. Alligator tool was sometimes used. Based on the experience during the FOSAR activities, we are developing a lancing system for Wolsung NPP unit 1. It will be designed and manufactured until November 2016.

Search and Retrieval of Foreign Objects for the Steam Generator of Wolsung NPP Unit 1

International Nuclear Information System (INIS)

Jeong, Woo-Tae; Lee, Kyung-Ho

2016-01-01

We developed a foreign object search and retrieval (FOSAR) system for Wolsung NPP unit 1 steam generators. The steam generators of Wolsung NPP unit 1 have one 2.5 inch hand hole and two 4 inch hand holes. The FOSAR system was designed to be installed through 4 inch hand holes. Using permanent magnet, the FOSAR system was firmly attached to the vertical annulus wall of the steam generator. We successfully developed the FOSAR system for Wolsung NPP unit 1. Using the developed FOSAR system, technicians successfully found and removed various foreign objects. Most of the foreign objects, we found, were made of carbon steel sheet, therefore magnet tool was the most useful to remove it. Alligator tool was sometimes used. Based on the experience during the FOSAR activities, we are developing a lancing system for Wolsung NPP unit 1. It will be designed and manufactured until November 2016

Main Control Room Upgrade for Kori Unit 1 in Korea

International Nuclear Information System (INIS)

Ha, Jae Taeg; Choi, Moon Jae

2014-01-01

Kori Unit 1 is a 30 years old nuclear power plant and its MCR and MCB was upgraded based on the latest Human Factors Engineering (HFE) principles. The objectives of applying the Human Factors Engineering (HFE) principles are to minimize the human errors and to enhance the safe operation of the plant. In order to systematically incorporate the HFE design principles into the Human System Interface (HSI) design, HFE Program Plan (HFEPP) for Kori Unit 1 was developed and the plan provided an overview of the HSI design process along with detailed methods and results. The upgrade includes addition of Bypassed and Inoperable Status Indication System (BISI) and the replacement of the conventional MMI devices such as hardwired hand switches, recorders and indicators with new advanced control and display devices using VDUs (Video Display Units). The VDUs significantly improve the effectiveness and efficiency of the monitoring function. Plant Monitoring System (PMS) and Plant Annunciator System (PAS) were upgraded also by replacing the outdated systems with advanced digital systems with future expansion capability. In addition, the MCR related equipment and/or facilities were replaced or improved. Some of these include the enhancement of MCR interior designs for better working environment, dimmable ceiling lighting, aesthetically pleasing decor of ceiling, wall and floor as well as ergonomically improved operator consoles

Main Control Room Upgrade for Kori Unit 1 in Korea

Energy Technology Data Exchange (ETDEWEB)

Ha, Jae Taeg; Choi, Moon Jae [KEPCO, Daejeon (Korea, Republic of)

2014-08-15

Kori Unit 1 is a 30 years old nuclear power plant and its MCR and MCB was upgraded based on the latest Human Factors Engineering (HFE) principles. The objectives of applying the Human Factors Engineering (HFE) principles are to minimize the human errors and to enhance the safe operation of the plant. In order to systematically incorporate the HFE design principles into the Human System Interface (HSI) design, HFE Program Plan (HFEPP) for Kori Unit 1 was developed and the plan provided an overview of the HSI design process along with detailed methods and results. The upgrade includes addition of Bypassed and Inoperable Status Indication System (BISI) and the replacement of the conventional MMI devices such as hardwired hand switches, recorders and indicators with new advanced control and display devices using VDUs (Video Display Units). The VDUs significantly improve the effectiveness and efficiency of the monitoring function. Plant Monitoring System (PMS) and Plant Annunciator System (PAS) were upgraded also by replacing the outdated systems with advanced digital systems with future expansion capability. In addition, the MCR related equipment and/or facilities were replaced or improved. Some of these include the enhancement of MCR interior designs for better working environment, dimmable ceiling lighting, aesthetically pleasing decor of ceiling, wall and floor as well as ergonomically improved operator consoles.

Chemical Decontamination at Browns Ferry Unit 1

International Nuclear Information System (INIS)

Hartwig, Ed; Reid, Richard

2003-01-01

In May, 2002, the Tennessee Valley Authority's (TVA) Board of Directors approved the recovery and restart of Unit 1 at Browns Ferry Nuclear Station. As an initial step in the site characterization and restart feasibility review, a majority of the primary reactor circuit was chemically decontaminated. Close cooperation between TVA and vendor personnel resulted in project completion ahead of schedule with outstanding results. The final average decontamination factors were excellent, and the final dose rates were very low, with contact readings on most points between one and three mRem/hr. In addition to allowing TVA to do a complete and thorough job of determining the feasibility of the Unit 1 restart, the decontamination effort will greatly reduce personnel exposure during plant recovery, both whole body exposure to gamma radiation and airborne exposure during pipe replacement efforts. The implementation of lessons learned from previous decontamination work performed at Browns Ferry, as well as decontamination efforts at other plants aided greatly in the success. Specific items of note are: (1) The initial leak check of the temporary decontamination system should include ancillary systems such as the spent resin system, as well as the main circulation loop. This could save time and dose exposure if leaks are discovered before the use of such systems is required. (2) Due to the quick turnaround time from the award of contract, a vendor representative was onsite early in the project to help with engineering efforts and procedures. This aided greatly in completing preparations for the decontamination. (3) The work was performed under a single maintenance activity. This resulted in great craft and plant support. (4) The constant coverage by the site's decontamination flush directors provided timely plant support and interface. (5) The FPC system isolation and back flushing to prevent residual chemicals from being left in the FPC system should have been addressed in more

Biblis 1,300 MW unit B in operation for thirty years

International Nuclear Information System (INIS)

Lauer, H.

2006-01-01

Over the past thirty years, unit B of the Biblis nuclear power station has contributed towards safe, reliable and non-polluting electricity generation. Unit B was the first 1,300 MW unit in the world confirming the good experience accumulated in the construction and operation of plants this size. It laid the foundation for the advanced development of nuclear power plants up to the convoy line. The good availability this plant has achieved in its operating cycles proves the mature state of technology and the high level of qualification and motivation of the power plant staff and the personnel of external firms contracted to work for Biblis. Biblis B has served as a reference plant in German nuclear safety research, demonstrating that units this size can be operated safely. Unit B is also living proof of the possibility to raise nuclear power plants built in the seventies to the current state of the art by implementing the appropriate backfitting and modernization measures. Today, Biblis B is operated at a safety level clearly higher than that to be achieved for new plants internationally. This is also evident from comparison with the guiding values for the safety of new facilities as published by the International Atomic Energy Agency (IAEA). (orig.)

Tumors associated with HIV / AIDS monitoring 45 patients between 1/1998 and 6/2004; Tumores asociados al VIH/SIDA seguimiento de 45 pacientes entre 1/1998 y 6/2004

Energy Technology Data Exchange (ETDEWEB)

Krygier, G.; Lombardo, K.; Sosa, A.; Ocampo,; Suárez P, R.; Muse, I. [Departamento de Oncología, Hospital de Clínicas, Facultad de Medicina (Uruguay)

2010-12-15

Full text: This paper is intended to show 45 patients with cancer associated the human immunodeficiency virus (HIV) / AIDS, diagnosed, treated and followed over a period of 6.5 years in our country. The medical records were retrospectively analyzed of cancer patients diagnosed HIV positive on 5 institutions public and private in our midst, in the period between 1/98 and 6/04 (Institute of Health, National Institute of Oncology, Hospital of Clinics, Service Comprehensive Medical, Spanish Mutual Aid Association). They took into account different variables (origin, medical record number, sex, age, sexual habits, addiction to injecting drugs, HIV diagnosis positive diagnosis of AIDS, infectious prophylaxis, antiretroviral therapy, lymphocyte start and in the evolution population viral load start and evolutionary, tumor type, stage, treatment received, date of last control and status the close of the work). We compared data collected by us AIDS Ministry report of Public Health. 24 cases were Kaposi sarcomas (one nodal exclusive), 11 were non-Hodgkin lymphomas (two of SNC and other gastric), 1 Hodgkin's Disease 1 rectal cancer, tongue cancer 1 1 laryngeal cancer, thyroid cancer 1 1 Melanoma 1 parotid cancer, cancer 1 Lung and breast cancer 1. No cervical tumors or recorded anal canal in the study population. Treatments received varied for each disease depending on the stage of the disease and viral load / Towns lymphocyte start. This is the first study with longer follow-up in our country HIV patients / AIDS-associated cancer, he reflected the difficulty in collecting data, various types of cancer in the study population and demand the need to create an accurate and accessible system of monitoring these patients.

Development of Neutronics Model for ShinKori Unit 1 Simulator

Energy Technology Data Exchange (ETDEWEB)

Hong, JinHyuk; Lee, MyeongSoo; Lee, SeungHo; Suh, JungKwan; Hwang, DoHyun [KEPRI, Daejeon (Korea, Republic of)

2008-05-15

ShinKori-Unit 1 and 2 is being built in the Kori site which will be operated at 2815 MWt of thermal core power. The purpose of this paper is to report on the performance of the developed neutronics model of ShinKori Unit 1 and 2. Also this report includes the convenient tool (XS2R5) for processing the large quantity of information received from the DIT/ROCS model and generating cross-sections. The neutronics model is based on the NESTLE code inserted to RELAP5/MOD3 thermal-hydraulics analysis code which was funded as FY-93 LDRD Project 7201 and is running on the commercial simulator environment tool (the 3KeyMaster{sup TM} of the WSC). As some examples for the verification of the developed neutronics model, some figures are provided. The output of the developed neutronics model is in accord with the Preliminary Safety Analysis Report (PSAR) of the reference plant.

Tube structural integrity evaluation of Palo Verde Unit 1 steam generators for axial upper-bundle cracking

International Nuclear Information System (INIS)

Woodman, B.W.; Begley, J.A.; Brown, S.D.; Sweeney, K.; Radspinner, M.; Melton, M.

1995-01-01

The analysis of the issue of upper bundle axial ODSCC as it apples to steam generator tube structural integrity in Unit 1 at the Palo Verde Nuclear generating Station is presented in this study. Based on past inspection results for Units 2 and 3 at Palo Verde, the detection of secondary side stress corrosion cracks in the upper bundle region of Unit 1 may occur at some future date. The following discussion provides a description and analysis of the probability of axial ODSCC in Unit 1 leading to the exceedance of Regulatory Guide 1.121 structural limits. The probabilities of structural limit exceedance are estimated as function of run time using a conservative approach. The chosen approach models the historical development of cracks, crack growth, detection of cracks and subsequent removal from service and the initiation and growth of new cracks during a given cycle of operation. Past performance of all Palo Verde Units as well as the historical performance of other steam generators was considered in the development of cracking statistics for application to Unit 1. Data in the literature and Unit 2 pulled tube examination results were used to construct probability of detection curves for the detection of axial IGSCC/IGA using an MRPC (multi-frequency rotating panake coil) eddy current probe. Crack growth rates were estimated from Unit 2 eddy current inspection data combined with pulled tube examination results and data in the literature. A Monte-Carlo probabilistic model is developed to provide an overall assessment of the risk of Regulatory Guide exceedance during plant operation

Analysis of steam-generator tube-rupture events combined with auxiliary-feedwater control-system failure for Three Mile Island-Unit 1 and Zion-Unit 1 pressurized water reactors

International Nuclear Information System (INIS)

Nassersharif, B.

1986-01-01

A steam-generator tube-rupture (SGTR) event combined with loss of all offsite alternating-current power and failure of the auxiliary-feedwater (AFW) control system has been investigated for the Three Mile Island-Unit 1 (TMI-1) and Zion-Unit 1 (Zion-1) pressurized water reactors. The Transient Reactor Analysis Code was used to simulate the accident sequence for each plant. The objectives of the study were to predict the plant transient response with respect to tube-rupture flow termination, extent of steam generator overfill, and thermal-hydraulic conditions in the steam lines. Two transient cases were calculated: (1) a TMI-1 SGTR and runaway-AFW transient, and (2) a Zion-1 SGTR and runaway-AFW transient. Operator actions terminated the tube-rupture flow by 1342 s (22.4 min) and 1440 s (24.0 min) for TMI-1 and Zion-1, respectively, but AFW injection was continued. The damaged steam generator (DSG) overfilled by 1273 s (21.2 min) for the TMI-1 calculation and by 1604 s (26.7 min) for the Zion-1 calculation. The DSG steam lines were completely filled by 1500 s (25 min) and 2000 s (33.3 min) for TMI-1 and Zion-1, respectively. The maximum subcooling in the steam lines was approx.63 K (approx.113 0 F) for TMI-1 and approx.44 K (approx.80 0 F) for Zion-1

100-HR-1 Operable Unit focused feasibility study report. Draft A

International Nuclear Information System (INIS)

1994-09-01

The standard Comprehensive Environmental Response, Compensation, and Liability Act of 1980 Feasibility Study (FS) includes development and screening of alternatives (phases 1 and 2) and the detailed analysis of alternatives (phase 3). This focused feasibility study (FFS) constitutes the phase 3 portion of the FS process. The FFS process is conducted in two stages, a Process Document (DOE-RL 1994a) and an operable unit-specific FFS document, such as this one. The FFS process is performed by implementing a ''plug-in'' style approach as defined in great detail in the Process Document. The objective of this operable unit-specific FFS is to provide decision makers with sufficient information to allow appropriate and timely selection of interim remedial measures (IRM) for sites associated with the 100-HR-1 Operable Unit. The IRM candidate waste sites are determined in the limited field investigation. Site profiles are developed for each of these waste sites. The site profiles are used in the application of the plug-in approach. The waste site either plugs into the analysis of the alternatives for the group, or deviations from the developed group alternatives are described and documented

Unit 1 and Unit 2 Nuclear Power Plant Mochovce construction finishing from primary contractor of technological part. Skoda Praha a. s. point of view

International Nuclear Information System (INIS)

Horky, F.

2000-01-01

In this paper the history of delivery of technological part for NPP V-1 Mochovce as well as of reconstruction and safety improvements by the Skoda Praha a.s. is presented. Primary contractor of technological part Skoda Praha together with its final suppliers proved ability to realize under hard conditions such a complicated work what was indisputedly Units 1 and 2 finishing. Company proved capability to conform itself flexibly in the course of work to requirements of customer for realization of safety measures which means that Units 1 and 2 fully satisfy international standards. By fulfilment of primary contractor of technology obligations and above all by takeover of complex responsibility for both Units putting in operation including responsibility for 'past' Skoda Praha put away one of basic problems which occurred in decision making to whom will be assigned construction finishing contract. These facts fully qualify Skoda Praha to be selected for possible Units 3 and 4 construction finishing as one of chief construction finishing participant

Bulk and thermal properties of the functional Tuffaceous Beds in holes USW G-1, UE-25 No. 1, and USW G-2, Yucca Mountain, Nevada

International Nuclear Information System (INIS)

Lappin, A.R.; Nimick, F.B.

1985-04-01

One emplacement horizon considered for a nuclear-waste repository at Yucca Mountain, Nevada, adjacent to the Nevada Test Site, consists of a zeolitized section. This section is defined here as an informal functional unit called the Tuffaceous Beds. This report describes the logic, data, and uncertainties involved in picking the boundaries of the functional unit in exploratory Holes USW G-1, UE-25a No. 1, and USW G-2. It also includes frequency profiles for grain density and porosity within the unit in the three exploratory holes. Results indicate that the functional Tuffaceous Beds range from 143 to 312 m in total thickness in the three holes studied. Unit-wide average grain densities and porosities of nonwelded ash-flows are 2.39 g/cm 3 and 0.33, respectively. The average matrix thermal conductivity of heavily zeolitized tuffs is constant at 1.95 W/m.K. This value leads to average estimated conductivities of saturated and dehydrated nonwelded ashflows within the functional Tuffaceous Beds of 1.3 and 0.9 W/m.K, respectively. Available confined measurements indicate an average predehydration linear-expansion coefficient of 6.7 x 10 -6 K -1 ; individual values range from 2.8 to 13.2 x 10 -6 K -1 . Transdehydration expansion behavior is variable, with average coefficients ranging from -56 to -29 x 10 -6 K -1 , depending on relative zeolite and (quartz + feldspar) contents. Postdehydration behavior is also sensitive to mineralogy, with average unconfined coefficients ranging from -4.5 to +7.8 x 10 -6 K -1 for the different subunits within the functional Tuffaceous Beds. For the nonwelded ashflows dominant within the unit, pre-, trans-, and postdehydration expansion coefficients of +6.7, -56, and -4.5 x 10 -6 K -1 are most representative. 21 refs, 7 figs., 12 tabs

Analysis of core melt accident in Fukushima Daiichi-Unit 1 nuclear reactor

International Nuclear Information System (INIS)

Tanabe, Fumiya

2011-01-01

In order to obtain a profound understanding of the serious situation in Unit 1 and Unit 2/3 reactors of Fukushima Daiichi Nuclear Power Station (hereafter abbreviated as 1F1 and 1F2/3, respectively), which was directly caused by tsunami due to a huge earthquake on 11 March 2011, analyses of severe core damage are performed. In the present report, the analysis method and 1F1 analysis are described. The analysis is essentially based on the total energy balance in the core. In the analysis, the total energy vs. temperature curve is developed for each reactor, which is based on the estimated core materials inventory and material property data. Temperature and melt fraction are estimated by comparing the total energy curve with the total stored energy in the core material. The heat source is the decay heat of fission products and actinides together with reaction heat from the zirconium steam reaction. (author)

26 CFR 1.959-1 - Exclusion from gross income of United States persons of previously taxed earnings and profits.

Science.gov (United States)

2010-04-01

... interest. The exclusion also applies to amounts taxed to United States shareholders as income of one... shareholders or their successors in interest as subpart F income of the controlled foreign corporation to which... shareholder's successor in interest. If a United States person (as defined in § 1.957-4) acquires from any...

Phase I remedial investigation report for the 300-FF-5 operable unit, Volume 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-01-01

The focus of this remedial investigation (RI) is the 300-FF-5 operable unit, one of five operable units associated with the 300 Area aggregate of the U.S. Department of Energy`s (DOE`s) Hanford Site. The 300-FF-5 operable unit is a groundwater operable unit beneath the 300-FF-1, 300-FF-2, and 300-FF-3 source operable units. This operable unit was designated to include all contamination detected in the groundwater and sediments below the water table that emanates from the 300-FF-1, 300-FF-2, and 300-FF-3 operable units (DOE-RL 1990a). In November 1989, the U.S. Environmental Protection Agency (EPA) placed the 300 Area on the National Priorities List (NPL) contained within Appendix B of the National Oil and Hazardous Substance Pollution Contingency Plan (NCP, 53 FR 51391 et seq.). The EPA took this action pursuant to their authority under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA, 42 USC 9601 et seq.). The DOE Richland Operations Office (DOE-RL), the EPA and Washington Department of Ecology (Ecology) issued the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), in May 1989 (Ecology et al. 1992, Rev. 2). This agreement, among other matters, governs all CERCLA efforts at the Hanford Site. In June 1990, a remedial investigation/feasibility study (RI/FS) workplan for the 300-FF-5 operable unit was issued pursuant to the Tri-Party Agreement.

Phase I remedial investigation report for the 300-FF-5 operable unit, Volume 1

International Nuclear Information System (INIS)

1994-01-01

The focus of this remedial investigation (RI) is the 300-FF-5 operable unit, one of five operable units associated with the 300 Area aggregate of the U.S. Department of Energy's (DOE's) Hanford Site. The 300-FF-5 operable unit is a groundwater operable unit beneath the 300-FF-1, 300-FF-2, and 300-FF-3 source operable units. This operable unit was designated to include all contamination detected in the groundwater and sediments below the water table that emanates from the 300-FF-1, 300-FF-2, and 300-FF-3 operable units (DOE-RL 1990a). In November 1989, the U.S. Environmental Protection Agency (EPA) placed the 300 Area on the National Priorities List (NPL) contained within Appendix B of the National Oil and Hazardous Substance Pollution Contingency Plan (NCP, 53 FR 51391 et seq.). The EPA took this action pursuant to their authority under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA, 42 USC 9601 et seq.). The DOE Richland Operations Office (DOE-RL), the EPA and Washington Department of Ecology (Ecology) issued the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), in May 1989 (Ecology et al. 1992, Rev. 2). This agreement, among other matters, governs all CERCLA efforts at the Hanford Site. In June 1990, a remedial investigation/feasibility study (RI/FS) workplan for the 300-FF-5 operable unit was issued pursuant to the Tri-Party Agreement

40 CFR Table 1 to Subpart Aaaa of... - Emission Limits for New Small Municipal Waste Combustion Units

Science.gov (United States)

2010-07-01

... Waste Combustion Units 1 Table 1 to Subpart AAAA of Part 60 Protection of Environment ENVIRONMENTAL... Standards of Performance for Small Municipal Waste Combustion Units for Which Construction is Commenced... Combustion Units For the following pollutants You must meet thefollowing emission limits a Using the...

Pressurized thermal shock evaluation of the Calvert Cliffs Unit 1 Nuclear Power Plant

Energy Technology Data Exchange (ETDEWEB)

Abbott, L [ed.

1985-09-01

An evaluation of the risk to the Calvert Cliffs Unit 1 nuclear power plant due to pressurized thermal shock (PTS) has been completed by Oak Ridge National Laboratory (ORNL) with the assistance of several other organizations. This evaluation was part of a Nuclear Regulatory Commission program designed to study the PTS risk to three nuclear plants, the other two plants being Oconee Unit 1 and H.B. Robinson Unit 2. The specific objectives of the program were to (1) provide a best estimate of the frequency of a through-the-wall crack in the pressure vessel at each of the three plants, together with the uncertainty in the estimated frequency and its sensitivity to the variables used in the evaluation; (2) determine the dominant overcooling sequences contributing to the estimated frequency and the associated failures in the plant systems or in operator actions; and (3) evaluate the effectiveness of potential corrective measures.

Pressurized thermal shock evaluation of the Calvert Cliffs Unit 1 Nuclear Power Plant

International Nuclear Information System (INIS)

Abbott, L.

1985-09-01

An evaluation of the risk to the Calvert Cliffs Unit 1 nuclear power plant due to pressurized thermal shock (PTS) has been completed by Oak Ridge National Laboratory (ORNL) with the assistance of several other organizations. This evaluation was part of a Nuclear Regulatory Commission program designed to study the PTS risk to three nuclear plants, the other two plants being Oconee Unit 1 and H.B. Robinson Unit 2. The specific objectives of the program were to (1) provide a best estimate of the frequency of a through-the-wall crack in the pressure vessel at each of the three plants, together with the uncertainty in the estimated frequency and its sensitivity to the variables used in the evaluation; (2) determine the dominant overcooling sequences contributing to the estimated frequency and the associated failures in the plant systems or in operator actions; and (3) evaluate the effectiveness of potential corrective measures

Almost there: Sector 7-8 being cooled to 4.5K!

CERN Multimedia

2007-01-01

The cool down of the 3km long LHC sector 7-8 between point 7 (Ferney-Voltaire) and point 8 (Prévessin) has entered a new phase. The cryostats with the superconducting magnets, which had been kept around 20 K (-253°C) for the past week, are gradually being cooled down to 4.5 K (-268°C) and filled with liquid helium. This new phase in the cooling process was successfully started on Monday 5 March and is progressing after a tuning session that lasted most of the day. To get down to 1.9K (-271°C), a new component of the cryogenics plant, the 1.8K units, will be turned on. In the meantime the teams who will carry out the magnet powering are busy validating the test procedures and running the interlock tests to ensure safe operation of the equipment. They are ready to start the powering as soon as the cryo team reaches stable conditions at 1.9 K. Follow the cool down on the Hardware Commissioning Coordination website.

43 CFR 45.4 - What deadlines apply to pending applications?

Science.gov (United States)

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What deadlines apply to pending applications? 45.4 Section 45.4 Public Lands: Interior Office of the Secretary of the Interior CONDITIONS AND PRESCRIPTIONS IN FERC HYDROPOWER LICENSES General Provisions § 45.4 What deadlines apply to pending applications...

Development of Regulatory Audit Programs for Wolsong Unit 1 Continued Operation

Energy Technology Data Exchange (ETDEWEB)

Kim, Hong Key; Nho, Seung Hwan; Song, Myung Ho [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2012-05-15

Wolsong Unit 1 (PHWR type) design life expires on November 20, 2010. In relation to it, KHNP submitted its application to get approval of the MEST on December 30, 2009 and KINS is under review to confirm the appropriateness of continued operation. For the comprehensive review of Wolsong Unit 1 continued operation, KINS has developed the review guidelines for PHWR type reactor including a total of 39 aging management program (AMP) items and 7 time limited aging analysis (TLAA) items. Evaluations or calculations to verify the integrity of nuclear components are required for plant specific AMP and TLAA items as well as the ones specified in the guidelines. In this paper, audit calculation programs developed for KINS staff use in reviewing applicant's submitted evaluation results are presented

Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.

Directory of Open Access Journals (Sweden)

Alice A Royal

Full Text Available The slow delayed-rectifier potassium current (IKs is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lead to hereditary long QT syndrome types 1 and 5, respectively. It is widely recognised that the KCNQ1/KCNE1 (Q1/E1 channel requires phosphatidylinositol-4,5-bisphosphate (PIP2 binding for function. We previously identified a cluster of basic residues in the proximal C-terminus of KCNQ1 that form a PIP2/phosphoinositide binding site. Upon charge neutralisation of these residues we found that the channel became more retained in the endoplasmic reticulum, which raised the possibility that channel-phosphoinositide interactions could play a role in channel trafficking. To explore this further we used a chemically induced dimerization (CID system to selectively deplete PIP2 and/or phosphatidylinositol-4-phosphate (PI(4P at the plasma membrane (PM or Golgi, and we subsequently monitored the effects on both channel trafficking and function. The depletion of PIP2 and/or PI(4P at either the PM or Golgi did not alter channel cell-surface expression levels. However, channel function was extremely sensitive to the depletion of PIP2 at the PM, which is in contrast to the response of other cardiac potassium channels tested (Kir2.1 and Kv11.1. Surprisingly, when using the CID system IKs was dramatically reduced even before dimerization was induced, highlighting limitations regarding the utility of this system when studying processes highly sensitive to PIP2 depletion. In conclusion, we identify that the Q1/E1 channel does not require PIP2 or PI(4P for anterograde trafficking, but is heavily reliant on PIP2 for channel function once at the PM.

Free tropospheric measurements of CS2 over a 45 deg N to 45 deg S latitude range

Science.gov (United States)

Tucker, B. J.; Maroulis, P. J.; Bandy, A. R.

1985-01-01

The mean value obtained from 52 free tropospheric measurements of CS2 over the 45 deg N-45 deg S latitude range was 5.7 pptv, with standard deviation and standard error of 1.9 and 0.3 pptv, respectively. Large fluctuations in the CS2 concentration are observed which reflect the apparent short atmospheric residence time and inhomogeneities in the surface sources of CS2. The amounts of CS2 in the Northern and Southern Hemispheres are statistically equal.

The reaction of 1,2-Dichloro-4,5-dinitrobenzene with hydroxide ion: roles of Meisenheimer complexes and radical pairs

Energy Technology Data Exchange (ETDEWEB)

Blasko, Andrei; Bunton, Clifford A.; Gillitt, Nichollas D.; Bacaloglu, Radu [Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA (United States); Yunes, Santiago F.; Zucco, Cesar, E-mail: c.zucco@ufsc.br, E-mail: santiago.yunes@ufsc.br [Departamento de Quimica, Universidade Federal de Santa Catarina, Florianopolis-SC (Brazil)

2013-07-15

The reaction of 1,2-dichloro-4,5-dinitrobenzene (DCDNB) with aqueous OH{sup -} produces (after acidification) 2-nitro-4,5-dichlorophenol with loss of NO{sub 2} . Nevertheless, with > 2 mol L{sup -1} OH{sup -}, only DCDNB was recovered due to the formation of the long-lived 3,6-dihydroxy Meisenheimer complex (M{sup 2-}), and that in acid, reverted to the starting material. Fast formation of monohydroxy Meisenheimer complex (M{sup 1-}) can be followed in DMSO:H{sub 2}O 7:3 v/v and rate constants for its interconversion with DCDNB and for formation and return with M{sup 2-} complex were estimated, with evidence for these reactions in DMSO:H{sub 2}O 1:1 v/v and H{sub 2}O. The rapid hydrogen exchange in OD{sup -}/D{sub 2}O limits the use of {sup 1}H nuclear magnetic resonance (NMR) spectroscopy in identifying intermediates. {sup 1}H and {sup 13}C NMR signals of M{sup 2-} complex were observed in DMSO-H{sub 2}O-KOH. There is evidence for the formation of free radicals in DMSO:H{sub 2} O 4:1 v/v, and overall kinetics in more aqueous medium were treated in terms of the transient existence of anionic radical pairs. (author)

Structure, computational and biochemical analysis of PcCel45A endoglucanase from Phanerochaete chrysosporium and catalytic mechanisms of GH45 subfamily C members

DEFF Research Database (Denmark)

Godoy, Andre S.; Pereira, Caroline S.; Ramia, Marina Paglione

2018-01-01

The glycoside hydrolase family 45 (GH45) of carbohydrate modifying enzymes is mostly comprised of ß-1,4-endoglucanases. Significant diversity between the GH45 members has prompted the division of this family into three subfamilies: A, B and C, which may differ in terms of the mechanism, general a...

32 CFR Appendix C to Part 45 - DD Form 215

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 215 C Appendix C to Part 45 National... CERTIFICATE OF RELEASE OR DISCHARGE FROM ACTIVE DUTY (DD FORM 214/5 SERIES) Pt. 45, App. C Appendix C to Part 45—DD Form 215 EC21OC91.050 ...

45 CFR 400.209 - Claims involving family units which include refugees who have been in the United States more than...

Science.gov (United States)

2010-10-01

... refugees who have been in the United States more than 36 months. 400.209 Section 400.209 Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Federal Funding Federal...

Compressed Air Quality, A Case Study In Paiton Coal Fired Power Plant Unit 1 And 2

Science.gov (United States)

Indah, Nur; Kusuma, Yuriadi; Mardani

2018-03-01

The compressed air system becomes part of a very important utility system in a Plant, including the Steam Power Plant. In PLN’S coal fired power plant, Paiton units 1 and 2, there are four Centrifugal air compressor types, which produce compressed air as much as 5.652 cfm and with electric power capacity of 1200 kW. Electricity consumption to operate centrifugal compressor is 7.104.117 kWh per year. Compressed air generation is not only sufficient in quantity (flow rate) but also meets the required air quality standards. compressed air at Steam Power Plant is used for; service air, Instrument air, and for fly Ash. This study aims to measure some important parameters related to air quality, followed by potential disturbance analysis, equipment breakdown or reduction of energy consumption from existing compressed air conditions. These measurements include counting the number of dust particles, moisture content, relative humidity, and also compressed air pressure. From the measurements, the compressed air pressure generated by the compressor is about 8.4 barg and decreased to 7.7 barg at the furthest point, so the pressure drop is 0.63 barg, this number satisfies the needs in the end user. The measurement of the number of particles contained in compressed air, for particle of 0.3 micron reaches 170,752 particles, while for the particle size 0.5 micron reaches 45,245 particles. Measurements of particles conducted at several points of measurement. For some point measurements the number of dust particle exceeds the standard set by ISO 8573.1-2010 and also NACE Code, so it needs to be improved on the air treatment process. To see the amount of moisture content in compressed air, it is done by measuring pressure dew point temperature (PDP). Measurements were made at several points with results ranging from -28.4 to 30.9 °C. The recommendation of improving compressed air quality in steam power plant, Paiton unit 1 and 2 has the potential to extend the life of

Brunswick Steam Electric Plant, Units 1 and 2. Annual operating report for 1976

International Nuclear Information System (INIS)

1977-01-01

Net electrical energy generated by Unit 1 was 30,399 MWH with the generator on line 334.5 hrs. Unit 2 generated 2,481,014 MWH with the generator on line 4,915.53 hrs. Information is presented concerning operations, shutdowns and power reductions, maintenance, power generation, modifications, changes to operational procedures, radiation exposures, and leak rate testing

应用新型煮练酶SKQ-45的散棉低温煮漂工艺优化%Application of novel scouring enzyme SKQ-45 in low temperature scouring and bleaching for loose cotton and its optimization

Institute of Scientific and Technical Information of China (English)

陈诚; 贾丽霞; 张梦婉; 何鹰

2016-01-01

Low temperature scouring and bleaching processes for loose cotton were carried out with scouring enzyme KQ-45 (SKQ-45), a type of novel low temperature catalytic auxiliary for hydrogen peroxide. Based on single factor analysis, the effects and optimization range of SKQ-45 dosage, temperature and time on the bundle strength and whiteness of loose cotton were discussed. The low temperature process with SKQ-45 was optimized by three-factor quadratic general rotary unitized design, and the experimental data was analyzed in DPS data processing system. The optimum process was determined as fol ows: SKQ-45 3.9 g/L, 36% H2O2 6.0 g/L, NaOH 2.0 g/L, bath ratio 1∶40, scoured at 54 ℃ for 55 min. The whiteness of loose cotton treated by the optimal process was 63.40%, which was higher than the high temperature alkali scour⁃ing and bleaching process. The bundle strength after scouring and dyeing was 1 774.56 and 1 599.64 cN, which increased 67.30% and 100.34% than the high temperature process, respectively. The K/S value and the fixation rate of dyed loose cotton increased 11.54% and 9.32%, respectively. Accordingly, the souring and bleaching result of SKQ-45 process was better than the high temperature process.%采用一种新型复合酶制剂——双氧水低温催化煮练酶KQ-45（SKQ-45）对散棉进行低温煮漂处理，在单因素分析的基础上讨论了SKQ-45用量、煮漂温度和时间对散棉断裂强力及白度的影响及优化范围，然后利用3因子2次通用旋转组合设计对SKQ-45低温煮漂工艺进行优化，并将优化数据在DPS数据处理系统中运行分析，从而得到SKQ-45煮漂的优化工艺：SKQ-453.9 g/L，36%H2O26.0 g/L，NaOH 2.0 g/L，温度54℃，时间55 min，浴比1∶40。经优化工艺处理的散棉白度达到了63.40%，高于高温碱煮漂工艺；煮漂后断裂强力及染后2次断裂强力分别为1774.56和1599.64 cN，较高温工艺分别提高了67.30%和100.34%�

15 CFR 14.45 - Cost and price analysis.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Cost and price analysis. 14.45 Section... COMMERCIAL ORGANIZATIONS Post-Award Requirements Procurement Standards § 14.45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with...

32 CFR 32.45 - Cost and price analysis.

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Cost and price analysis. 32.45 Section 32.45... price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be accomplished in various ways...

24 CFR 84.45 - Cost and price analysis.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Cost and price analysis. 84.45....45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with every procurement action. Price analysis may be accomplished in various...

Activities of the Entomology Unit. Report No.1, 1988

International Nuclear Information System (INIS)

1988-11-01

This semiannual report describes the activities carried out by the staff of the Entomology Unit at the Agency's Laboratories, Seibersdorf, between 1 January and 31 July 1988. The colonization of Glossina spp. was continued to provide insects for ongoing and anticipated control programmes and supporting research activities. Hybridization of the two subspecies palpalis palpalis (GPP) and palpalis gambiensis (GPG) was studied. Rearing of medfly was studied. Figs and tabs

Specific characteristics of family 45 endoglucanases from Mucorales in the use of textiles and laundry.

Science.gov (United States)

Shimonaka, Atsushi; Koga, Jinichiro; Baba, Yuko; Nishimura, Tomoko; Murashima, Koichiro; Kubota, Hidetoshi; Kono, Toshiaki

2006-04-01

We examined the characteristics of family 45 endoglucanases (glycoside hydrolases family 45; GH45) from Mucorales belonging to Zygomycota in the use of textiles and laundry. The defibrillation activities on lyocell fabric of family 45 endoglucanases from Mucorales, such as RCE1 and RCE2 from Rhizopus oryzae, MCE1 and MCE2 from Mucor circinelloides, and PCE1 from Phycomyces nitens, were much higher than those of the other family 45 endoglucanases. By contrast, family 45 endoglucanases from Mucorales were less resistant to anionic surfactant and oxidizing agent, main components in detergents, than the other family 45 endoglucanases. RCE1 consists of two distinct modules, a catalytic module and a carbohydrate-binding module family 1 (CBM1), and these common specific characteristics were considered to due to the catalytic module, but not to the CBM1.

75 FR 80547 - Carolina Power & Light Company, Shearon Harris Nuclear Power Plant, Unit No. 1; Exemption

Science.gov (United States)

2010-12-22

..., Shearon Harris Nuclear Power Plant, Unit No. 1; Exemption 1.0 Background Carolina Power & Light Company... operation of the Shearon Harris Nuclear Power Plant (HNP), Unit 1. The license provides, among other things... request to generically extend the rule's compliance date for all operating nuclear power plants, but noted...

Inventory of power plants in the United States as of January 1, 1996

International Nuclear Information System (INIS)

1996-12-01

The Inventory of Power Plants in the United States provides annual statistics on generating units operated by electric utilities in the United States (the 50 States and the District of Columbia). Statistics presented in this report reflect the status of generating units as of January 1, 1996. The publication also provides a 10-year outlook for generating unit additions. This report is prepared annually by the Coal and Electric Data and Renewables Division; Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); U.S. Department of Energy (DOE). Data summarized in this report are useful to a wide audience including Congress; Federal and State agencies; the electric utility industry; and the general public. Data presented in this report were assembled and published by the EIA to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 as amended

Inventory of power plants in the United States as of January 1, 1996

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-01

The Inventory of Power Plants in the United States provides annual statistics on generating units operated by electric utilities in the United States (the 50 States and the District of Columbia). Statistics presented in this report reflect the status of generating units as of January 1, 1996. The publication also provides a 10-year outlook for generating unit additions. This report is prepared annually by the Coal and Electric Data and Renewables Division; Office of Coal, Nuclear, Electric and Alternate Fuels; Energy Information Administration (EIA); U.S. Department of Energy (DOE). Data summarized in this report are useful to a wide audience including Congress; Federal and State agencies; the electric utility industry; and the general public. Data presented in this report were assembled and published by the EIA to fulfill its data collection and dissemination responsibilities as specified in the Federal Energy Administration Act of 1974 as amended.

Implementing the Environmental Management System ISO 14001 at the Cernavoda NPP Unit 1

International Nuclear Information System (INIS)

Jelev, Adrian

2003-01-01

An environmental management plan (EMP) has been developed for the Cernavoda NPP Unit 1. It contains the necessary components for identification and management of the environmental aspects of NPP. The environmental policy of the 'Nuclearelectrica' National Society and the associated EMP are the basis for the Environment Management System that will be implemented at Cernavoda NPP. The final step of this process will be the ISO 14001 certification. This paper points out to the main aspects concerning the implementation of the ISO 14001 system at Cernavoda NPP Unit 1. (author)

Science, society, and America's nuclear waste: Unit 1, Nuclear waste

International Nuclear Information System (INIS)

1992-01-01

This is unit 1 in a four-unit secondary curriculum. It is intended to provide information about scientific and societal issues related to the management of spent nuclear fuel from generation of electricity at nuclear powerplants and high-level radioactive waste from US national defense activities. The curriculum, supporting classroom activities, and teaching materials present a brief discussion of energy and electricity generation, including that produced at nuclear powerplants; information on sources, amounts, location, and characteristics of spent nuclear fuel and high-level radioactive waste; sources, types and effects of radiation; US policy for managing and disposing of spent nuclear fuel and high-level radioactive waste and what other countries are doing; and the components of the nuclear waste management system

Station black out of Fukushima Daiichi Nuclear Power Station Unit 1 was not caused by tsunamis

International Nuclear Information System (INIS)

Ito, Yoshinori

2013-01-01

Station black out (SBO) of Fukushima Daiichi Nuclear Power Station Unit 1 would be concluded to be caused before 15:37 on March 11, 2011 because losses of emergency ac power A system was in 15:36 and ac losses of B system in 15:37 according to the data published by Tokyo Electric Power Co. (TEPCO) in May 10, 2013. Tsunami attacked the site of Fukushima Daiichi Nuclear Power Station passed through the position of wave amplitude meter installed at 1.5 km off the coast after 15:35 and it was also recognized tsunami arrived at the coast of Unit 4 sea side area around in 15:37 judging from a series of photographs taken from the south side of the site and general knowledge of wave propagation. From a series of photographs and witness testimony, tsunami didn't attack Fukushima Daiichi Nuclear Power Station uniformly and tsunami's arrival time at the site of Unit 1 would be far later than arrival time at the coast of Unit 4 sea side area, which suggested it would be around in 15:39. TEPCO insisted tsunami passed through 1.5 km off the coast around in 15:33 and clock of wave amplitude meter was incorrect, which might be wrong. Thus SBO of Fukushima Daiichi Nuclear Power Station Unit 1 occurred before tsunami's arrival at the site of Unit 1 and was not caused by tsunami. (T. Tanaka)

Pickering unit 1 containment leakage characterization

International Nuclear Information System (INIS)

Zakaib, G.D.

1994-01-01

Results of the design pressure test carried out on Pickering Reactor Building number 1 during late 1992 showed that the leakage rate of the building was close to the safety analysis value of 2.7% contained mass per hour at the design pressure of 41.4 kPa(g) and was significantly higher than that reported after the previous test conducted in the spring of 1987. This unexpected finding initiated the longest and the most comprehensive containment leakage investigation ever undertaken by Ontario Hydro. A thorough investigation of leakage behaviour by repeated testing, inspections, leak search and analysis was launched. The extensive leak search effort included items such as: leak source detection by soap solution application, use of ultrasonic detectors, fogging and tracer gas techniques, systematic systems isolation, thermal imaging of the exterior, and quantification of leak sites by flowmeter and bagging. Using a specially designed volumetric technique, the root cause of the problem was finally confirmed as being due to 'pressure dependent laminar leakage' through the hairline cracks in the dome concrete. Structural analysis indicated that the thermal gradients and pressure loading combined to cause the cracking early in the structure's operating history and that overall structural integrity has not been compromised. Leakage rate analysis using a new fluid mechanics model augmented by the effect of thermal strains indicated that the leakage could be significantly less under certain transient temperature gradient conditions. Several options for repairing the dome were considered by a multidisciplinary team and it was finally decided to apply a specially engineered multilayer elastomeric coating to the exterior concrete surface. When the unit was re-tested in October 1993, a dramatic ten-fold improvement in leakage rate (down to 0.25%/h at design pressure) was observed. This is lower than even the commissioning results and comparable to the performance of newer units

45 CFR 74.43 - Competition.

Science.gov (United States)

2010-10-01

... to ensure objective contractor performance and eliminate unfair competitive advantage, contractors... 45 Public Welfare 1 2010-10-01 2010-10-01 false Competition. 74.43 Section 74.43 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION UNIFORM ADMINISTRATIVE REQUIREMENTS FOR AWARDS...

Evaluation on radioactive waste disposal amount of Kori Unit 1 reactor vessel considering cutting and packaging methods

International Nuclear Information System (INIS)

Choi, Yu Jong; Lee, Seong Cheol; Kim, Chang Lak

2016-01-01

Decommissioning of nuclear power plants has become a big issue in South Korea as some of the nuclear power plants in operation including Kori unit 1 and Wolsung unit 1 are getting old. Recently, Wolsung unit 1 received permission to continue operation while Kori unit 1 will shut down permanently in June 2017. With the consideration of segmentation method and disposal containers, this paper evaluated final disposal amount of radioactive waste generated from decommissioning of the reactor pressure vessel in Kori unit 1 which will be decommissioned as the first in South Korea. The evaluation results indicated that the final disposal amount from the top and bottom heads of the reactor pressure vessel with hemisphere shape decreased as they were cut in smaller more effectively than the cylindrical part of the reactor pressure vessel. It was also investigated that 200 L and 320 L radioactive waste disposal containers used in Kyung-Ju disposal facility had low payload efficiency because of loading weight limitation

Analysis of core damage frequency from internal events: Surry, Unit 1

International Nuclear Information System (INIS)

Harper, F.T.

1986-11-01

This document contains the accident sequence analyses for Surry, Unit 1; one of the reference plants being examined as part of the NUREG-1150 effort by the Nuclear Regulatory Commission (NRC). NUREG-1150 will document the risk of a selected group of nuclear power plants. As part of that work, this report contains the overall core damage frequency estimate for Surry, Unit 1, and the accompanying plant damage state frequencies. Sensitivity and uncertainty analyses provide additional insights regarding the dominant contributors to the Surry core damage frequency estimate. The numerical results are driven to some degree by modeling assumptions and data selection for issues such as reactor coolant pump seal LOCAs, common cause failure probabilities, and plant response to station blackout and loss of electrical bust initiators. The sensitivity studies explore the impact of alternate theories and data on these issues

Structural, morphological, impedance and magnetic studies of nanostructured LiNi0.45M0.1Mn0.45O2 (MCu and Al cathode materials for lithium-ion batteries

Directory of Open Access Journals (Sweden)

N. Murali

2017-12-01

Full Text Available Layered structure LiNi0.45M0.1Mn0.45O2 (MCu and Al cathode materials for lithium-ion batteries are synthesized by sol–gel auto combustion method. The structural, morphological, electrical and magnetic properties are examined by X-ray diffraction (XRD, field effect scanning electron microscope FESEM, FT-IR, EIS and ESR. XRD data revealed the rhombohedral and α-NaFeO2 structure with a space group R-3m. The electrical conductivity, dielectric constant, and dielectric loss are measured in the room temperature at a frequency ranging from 20 Hz to 1 MHz. The electrical conductivity of the compound is measured by AC impedance. An effective improvement in the electrical conductivity of order 5.42 × 10−6 S/cm is observed for the copper doped LNMO compounds. ESR spectra is recorded at room temperature on a Bruker EMX model X-band spectrometer operating at a frequency of 9.50 GHz. The critical dopants of Cu, with minimum g-factor and maximum line-width (W are observed. Keywords: Sol–gel, FESEM, AC impedance, ESR

Preparation of 18F-FDG by basic hydrolysis on '1-pot' FDG synthesis module

International Nuclear Information System (INIS)

Li Qiming; Jin Rongbing; Fan Xijiang

2007-01-01

'1-pot' equipment is an automatic synthesis module of producing 18 F-FDG by acid hydrolysis process. Simple changes in the chemistry, plumbing, and programming of CPCU enable two back-to-back '1-pot' systems in a unit. The preparation of precursor of 18 F-FDG is the same with origin. The results of experiments showed that by basic hydrolysis procedure, the synthesis time is shorten from 45-50 min to 30-35 min, uncorrected synthesis yield can be increased from 45%-50% to 60%-65%, and the preparing procedure is stable. The quality of 18 F-FDG meets the requirements under USP fludeoxyglucose 18 F injection, radiochemical purity is more than 99% especially by HPLC. With '1-pot' FDG synthesis module Chemical Processing Control Unit (CPCU), 18 F-FDG can be prepared by basic hydrolysis process. (authors)

Inspection accessibility study of the Millstones Unit 1 Reactor Pressure Vessel

International Nuclear Information System (INIS)

Calhoun, G.; Kapoor, A.; Davis, J.B.

1990-07-01

The need for more extensive ultrasonic examination of the Reactor Pressure Vessel (RPV) shell welds at some of the BWR plants is becoming apparent. Recent NRC comments regarding limits on future inspection relief requests and proposed revisions to the ASME Boiler and Pressure Vessel Code, Section 11 have caused BWR plant owners and vendors of inspection services to look at inspection tooling that would allow for the ultrasonic examination of RPV shell welds previously considered inaccessible. One approach to inspection of the RPV shell welds that will allow for greater coverage at some BWR plants is to perform these inspections from inside the vessel. In late 1988, Westinghouse received a contract from Northeast Utilities to examine the flange ligament areas and the shell welds in the upper portion of the Millstone Unit 1 PRV during an outage scheduled to begin in April 1989. This examination was performed with an inspection tool placed inside of the vessel and the UDRPS data acquisition system. The inspection tool was based on tooling used routinely at the Swedish and Finnish BWRs. The object of RP C105-1 was to use the information gathered prior to and during the Millstone Unit 1 examination and to perform an inspection accessibility study and prepare a report covering the lessons learned during the examination that would benefit other BWR utilities considering similar inspections. The final report consists of two volumes. This document, Volume 1, describes a 3D model of the Millstone Unit 1 PRV that was based on information obtained from plant drawings. The model is a useful tool for visualizing areas of limited access from both inside and outside of the RPV. 5 refs., 38 figs., 4 tabs

Effect of the π-conjugation length on the properties and photovoltaic performance of A–π–D–π–A type oligothiophenes with a 4,8-bis(thienylbenzo[1,2-b:4,5-b′]dithiophene core

Directory of Open Access Journals (Sweden)

Ni Yin

2016-08-01

Full Text Available Benzo[1,2-b:4,5-b′]dithiophene (BDT is an excellent building block for constructing π-conjugated molecules for the use in organic solar cells. In this paper, four 4,8-bis(5-alkyl-2-thienylbenzo[1,2-b:4,5-b′]dithiophene (TBDT-containing A–π–D–π–A-type small molecules (COOP-nHT-TBDT, n = 1, 2, 3, 4, having 2-cyano-3-octyloxy-3-oxo-1-propenyl (COOP as terminal group and regioregular oligo(3-hexylthiophene (nHT as the π-conjugated bridge unit were synthesized. The optical and electrochemical properties of these compounds were systematically investigated. All these four compounds displayed broad absorption bands over 350–600 nm. The optical band gap becomes narrower (from 1.94 to 1.82 eV and the HOMO energy levels increased (from −5.68 to −5.34 eV with the increase of the length of the π-conjugated bridge. Organic solar cells using the synthesized compounds as the electron donor and PC61BM as the electron acceptor were fabricated and tested. Results showed that compounds with longer oligothiophene π-bridges have better power conversion efficiency and higher device stability. The device based on the quaterthiophene-bridged compound 4 gave a highest power conversion efficiency of 5.62% with a VOC of 0.93 V, JSC of 9.60 mA·cm−2, and a FF of 0.63.

Technical specifications: Seabrook Station, Unit 1 (Docket No. 50-443)

International Nuclear Information System (INIS)

1990-03-01

The Seabrook Station, Unit 1 Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

Calvert Cliffs Nuclear Power Plant, Units 1 and 2. Annual operating report: January--December 1976

International Nuclear Information System (INIS)

1977-01-01

Unit 1 successfully completed its first core cycle with unit availability of 95.2 percent. Saltwater leakage into the condenser continues to be a problem. Unit 2 achieved initial criticality November 30 and was initially paralleled to the Baltimore system on December 7. Information is presented concerning operations, specifications, maintenance, shutdowns and power reduction, and personnel exposures