78 FR 69147 - Ranger Alternative Management, L.P. and Ranger Funds Investment Trust; Notice of Application

Science.gov (United States)

2013-11-18

...] Ranger Alternative Management, L.P. and Ranger Funds Investment Trust; Notice of Application November 12... Application: Applicants request an order that would permit (a) certain open-end management investment... Units; and (e) certain registered management investment companies and unit investment trusts outside of...

Effect of nicotine on melanogenesis and antioxidant status in HEMn-LP melanocytes

International Nuclear Information System (INIS)

Delijewski, Marcin; Beberok, Artur; Otręba, Michał; Wrześniok, Dorota; Rok, Jakub; Buszman, Ewa

2014-01-01

Nicotine is a natural ingredient of tobacco plants and is responsible for the addictive properties of tobacco. Nowadays nicotine is also commonly used as a form of smoking cessation therapy. It is suggested that nicotine may be accumulated in human tissues containing melanin. This may in turn affect biochemical processes in human cells producing melanin. The aim of this study was to examine the effect of nicotine on melanogenesis and antioxidant status in cultured normal human melanocytes HEMn-LP. Nicotine induced concentration-dependent loss in melanocytes viability. The value of EC 50 was determined to be 7.43 mM. Nicotine inhibited a melanization process in human light pigmented melanocytes and caused alterations of antioxidant defense system. Significant changes in cellular antioxidant enzymes: superoxide dismutase and catalase activities and in hydrogen peroxide content were stated. The obtained results may explain a potential influence of nicotine on biochemical processes in melanocytes in vivo during long term exposition to nicotine. - Graphical abstract: Nicotine inhibits melanogenesis and induces oxidative stress in HEMn-LP melanocytes. - Highlights: • Nicotine induces concentration-dependent loss in melanocytes viability. • Nicotine in non-cytotoxic concentrations inhibits melanogenesis. • Nicotine in higher concentrations induces oxidative stress

Effect of nicotine on melanogenesis and antioxidant status in HEMn-LP melanocytes

Energy Technology Data Exchange (ETDEWEB)

Delijewski, Marcin; Beberok, Artur; Otręba, Michał; Wrześniok, Dorota; Rok, Jakub; Buszman, Ewa, E-mail: ebuszman@sum.edu.pl

2014-10-15

Nicotine is a natural ingredient of tobacco plants and is responsible for the addictive properties of tobacco. Nowadays nicotine is also commonly used as a form of smoking cessation therapy. It is suggested that nicotine may be accumulated in human tissues containing melanin. This may in turn affect biochemical processes in human cells producing melanin. The aim of this study was to examine the effect of nicotine on melanogenesis and antioxidant status in cultured normal human melanocytes HEMn-LP. Nicotine induced concentration-dependent loss in melanocytes viability. The value of EC{sub 50} was determined to be 7.43 mM. Nicotine inhibited a melanization process in human light pigmented melanocytes and caused alterations of antioxidant defense system. Significant changes in cellular antioxidant enzymes: superoxide dismutase and catalase activities and in hydrogen peroxide content were stated. The obtained results may explain a potential influence of nicotine on biochemical processes in melanocytes in vivo during long term exposition to nicotine. - Graphical abstract: Nicotine inhibits melanogenesis and induces oxidative stress in HEMn-LP melanocytes. - Highlights: • Nicotine induces concentration-dependent loss in melanocytes viability. • Nicotine in non-cytotoxic concentrations inhibits melanogenesis. • Nicotine in higher concentrations induces oxidative stress.

West Africa LP gas market development study

International Nuclear Information System (INIS)

2001-01-01

Jointly sponsored with the World Bank, this essential study explores the opportunity for greatly expanded LP Gas use in the West Africa region. LP Gas supply in the area is increasing rapidly, This offers the opportunity for bringing modern energy to millions without current access, protects forests the only current source of energy for many, and encourages governments to adopt proactive policies that will reap benefits of the increasing availability of LP Gas. (author)

Missile defense in the United States

OpenAIRE

Heurlin, Bertil

2004-01-01

The basic arguments of this paper are, first, that the current US-missile defense, being operative from fall 2004, is based upon the former experiences with missile defense, second, that missile defense closely associated with weapons of mass destruction has gained the highest priority in American national security policy due to the 9.11 attacks, and third, that the superior argument for establishing an American missile defense is to maintain global, long term political-strategic superiority....

Development of safety function assessment trees for pressurized heavy water reactor LP/SD operations

International Nuclear Information System (INIS)

Yang, Hui Chang; Chung, Chang Hyun; Kim, Ki Yong; Jee, Moon Hak; Sung, Chang Kyoung

2003-01-01

The objective of Configuration Risk Management Program(CRMP) is to maintain the safety level by assuring the defense-in-depth of nuclear power plant while the configurations are changed during plant operations, especially for the LP/SD. Such a safety purpose can be achieved by establishing the risk monitoring programs with both quantitative and qualitative features. Generally, the quantitative risk evaluation models, i.e., PRA models are used for the risk evaluation during full power operation, and the qualitative risk evaluation models such as safety function assessment trees are used. Through this study, safety function assessment trees were developed

View of the LP gas supply/demand in Asia and a survey of the Middle East trend; Asia no LP gas jukyu tenbo to Chuto doko chosa

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-09-01

A study was made on the LP gas supply/demand in Asia including an outlook for 2000. Eleven countries in Asia including NIES countries, ASEAN countries, China and India have been continuing their rapid growth of economy and have rapidly been increasing their energy consumption. There, LP gas spreads as a home use fuel, and countries excluding some LP gas producing countries depend considerably upon the import from the Middle East. The LP gas consumption quantity is steadily increasing in China and India having huge population, etc., and dependence of LP gas is increasing upon LP gas producing countries of the Middle East. Nevertheless, in the Middle East, the domestic consumption of LP gas, mostly butane, is increasing. Namely, butane is used as raw material of MTBE, and LP gas as that of petroleum chemicals. The Middle East has a lot of plant projects of a sizable size in the future, which predicts that LP gas export from LP gas producing countries of the Middle East is decreasing. 2 refs., 62 figs., 57 tabs.

LP formulation of asymmetric zero-sum stochastic games

KAUST Repository

Li, Lichun

2014-12-15

This paper provides an efficient linear programming (LP) formulation of asymmetric two player zero-sum stochastic games with finite horizon. In these stochastic games, only one player is informed of the state at each stage, and the transition law is only controlled by the informed player. Compared with the LP formulation of extensive stochastic games whose size grows polynomially with respect to the size of the state and the size of the uninformed player\\'s actions, our proposed LP formulation has its size to be linear with respect to the size of the state and the size of the uninformed player, and hence greatly reduces the computational complexity. A travelling inspector problem is used to demonstrate the efficiency of the proposed LP formulation.

LP formulation of asymmetric zero-sum stochastic games

KAUST Repository

Li, Lichun; Shamma, Jeff S.

2014-01-01

This paper provides an efficient linear programming (LP) formulation of asymmetric two player zero-sum stochastic games with finite horizon. In these stochastic games, only one player is informed of the state at each stage, and the transition law is only controlled by the informed player. Compared with the LP formulation of extensive stochastic games whose size grows polynomially with respect to the size of the state and the size of the uninformed player's actions, our proposed LP formulation has its size to be linear with respect to the size of the state and the size of the uninformed player, and hence greatly reduces the computational complexity. A travelling inspector problem is used to demonstrate the efficiency of the proposed LP formulation.

Flygtninge på langvarig starthjælp

DEFF Research Database (Denmark)

Johansen, Adam; Højland, Marianne; Hansen, Henning

Spørgeskema-, fokusgruppe- og interviewbaseret undersøgelse af personlige og sociale konsekvenser af familiers forsørgelse på starthjælp. Kvalitativ og kvantitativ undersøgelse af starthjælpens konsekvenser for flygtningefamilier med mere end 1 år på starthjælp...

Meningococcal Serogroup B Bivalent rLP2086 Vaccine Elicits Broad and Robust Serum Bactericidal Responses in Healthy Adolescents

DEFF Research Database (Denmark)

Vesikari, Timo; Østergaard, Lars Jørgen; Diez-Domingo, Javier

2015-01-01

BACKGROUND: Neisseria meningitidis serogroup B (MnB) is a leading cause of invasive meningococcal disease in adolescents and young adults. A recombinant factor H binding protein (fHBP) vaccine (Trumenba(®); bivalent rLP2086) was recently approved in the United States in individuals aged 10-25 years....... Immunogenicity and safety of 2- or 3-dose schedules of bivalent rLP2086 were assessed in adolescents. METHODS: Healthy adolescents (11 to ... bactericidal antibody assay using human complement (hSBA). Safety assessments included local and systemic reactions and adverse events. RESULTS: Bivalent rLP2086 was immunogenic when administered as 2 or 3 doses; the most robust hSBA responses occurred with 3 doses. The proportion of subjects with hSBA titers...

Trigonometric bases for matrix weighted Lp-spaces

DEFF Research Database (Denmark)

Nielsen, Morten

2010-01-01

We give a complete characterization of 2π-periodic matrix weights W for which the vector-valued trigonometric system forms a Schauder basis for the matrix weighted space Lp(T;W). Then trigonometric quasi-greedy bases for Lp(T;W) are considered. Quasi-greedy bases are systems for which the simple...

Genetic invalidation of Lp-PLA2 as a therapeutic target

DEFF Research Database (Denmark)

Gregson, John M; Freitag, Daniel F; Surendran, Praveen

2017-01-01

AIMS: Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether Lp-PLA2 enzyme activity is causally relevant to coronary heart disease. METHODS: In 72...... (Val379Ala (rs1051931)) in PLA2G7, the gene encoding Lp-PLA2. We supplemented de-novo genotyping with information on a further 45,823 coronary heart disease patients and 88,680 controls in publicly available databases and other previous studies. We conducted a systematic review of randomized trials...... to compare effects of darapladib treatment on soluble Lp-PLA2 activity, conventional cardiovascular risk factors, and coronary heart disease risk with corresponding effects of Lp-PLA2-lowering alleles. RESULTS: Lp-PLA2 activity was decreased by 64% (p = 2.4 × 10(-25)) with carriage of any of the four loss...

77 FR 73089 - Cambria Investment Management, L.P. and Cambria ETF Trust; Notice of Application

Science.gov (United States)

2012-12-07

... Investment Management, L.P. and Cambria ETF Trust; Notice of Application November 30, 2012. AGENCY... (e) certain registered management investment companies and unit investment trusts outside of the same... Jennifer L. Sawin, Branch Chief, at (202) 551-6821 (Division of Investment Management, Office of Investment...

77 FR 74884 - Cambria Investment Management, L.P. and Cambria ETF Trust; Notice of Application

Science.gov (United States)

2012-12-18

... Investment Management, L.P. and Cambria ETF Trust; Notice of Application December 12, 2012. AGENCY... request an order that permits: (a) Actively-managed series of certain open-end management investment... registered management investment companies and unit investment trusts outside of the same group of investment...

Lp-dual affine surface area forms of Busemann–Petty type problems

Indian Academy of Sciences (India)

Associated with the notion of Lp-intersection body which was defined ... Lp-dual affine surface area; Lp-intersection body; Busemann–Petty ..... [11] Schneider R, Convex Bodies: The Brunn–Minkowski Theory (1993) (Cambridge: Cam-.

Technical Soddi Defenses: The Trojan Horse Defense Revisited

Directory of Open Access Journals (Sweden)

Chad Steel

2014-12-01

Full Text Available In 2004, the Trojan horse defense was at a crossroads, with two child pornography cases where it was successfully employed in the United Kingdom, resulting in acquittals.  The original Trojan horse defense has now become part of the more general “technical SODDI” defense, which includes the possibility of unknown actors using unsecured Wi-Fi connections or having physical access to a computer to perform criminal acts.  In the past ten years, it has failed to be effective in the United States for criminal cases, with no published acquittals in cases where it was the primary defense.  In the criminal cases where it has been used as leverage in plea negotiations, there has been either poor forensics performed by the prosecution or political pressure to resolve a matter.  On the civil side, however, the defense has been wildly successful, effectively shutting down large John Doe copyright infringement litigation against non-commercial violators.  

LpMab-19 Recognizes Sialylated O-Glycan on Thr76 of Human Podoplanin.

Science.gov (United States)

Ogasawara, Satoshi; Kaneko, Mika K; Kato, Yukinari

2016-08-26

Human podoplanin (hPDPN) is expressed in lymphatic vessels, pulmonary type-I alveolar cells, and renal glomerulus. The hPDPN/C-type lectin-like receptor-2 (CLEC-2) interaction is involved in platelet aggregation and cancer metastasis. High expression of hPDPN in cancer cells or cancer-associated fibroblasts (CAFs) leads to a poor prognosis for cancer patients. In our previous research, we reported on several anti-hPDPN monoclonal antibodies (mAbs), including LpMab-2, LpMab-3, LpMab-7, LpMab-9, LpMab-12, LpMab-13, and LpMab-17 of mouse IgG 1 subclass, which were produced using CasMab technology. Here we produced a novel anti-hPDPN mAb LpMab-19 of mouse IgG 2b subclass. Flow cytometry revealed that the epitope of LpMab-19 includes O-glycan, which is attached to Thr76 of hPDPN. We further identified the minimum epitope of LpMab-19 as Thr76-Arg79 of hPDPN. Immunohistochemistry revealed that LpMab-19 is useful for detecting not only normal cells, including lymphatic vessels, but also glioblastoma and oral squamous cell carcinoma cells. LpMab-19 could be useful for investigating the physiological function of O-glycosylated hPDPN.

The Excessive Profits of Defense Contractors: Evidence and Determinants

Science.gov (United States)

2012-04-30

UNILEVER NV $112,089,508 292 UL 2000 11 MOOG, INC. $111,608,841 293 MOG.A 3728 11 ALON USA L.P. $111,102,800 296 ALJ 2911 11 COCA - COLA ENTERPRISES...audits and investigations. As a national leader in the fight against procurement fraud, Miller participates in the U.S. Attorney General’s Financial Fraud...Excessive Profits of Defense Contractors: Evidence and Determinants1 Chong Wang—Wang is an assistant professor of financial management in the

LEP dominates LP-HEP

Energy Technology Data Exchange (ETDEWEB)

Fraser, Gordon

1991-09-15

CERN's LEP electron-positron collider was the star of this year's major physics meeting - the Joint International Lepton-Photon Symposium and Europhysics Conference on High Energy Physics (LP-HEP) - held in Geneva from 25 July - 1 August.

78 FR 45592 - DeltaPoint Capital IV, LP;

Science.gov (United States)

2013-07-29

..., Suite 160, Pittsford, NY 14534. The financing was contemplated for working capital. The financing is... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0662] DeltaPoint Capital IV, LP; Notice Seeking... given that DeltaPoint Capital IV, L.P., 45 East Avenue, 6th Floor, Rochester, NY 14604, Federal...

Sparse Adaptive Channel Estimation Based on lp-Norm-Penalized Affine Projection Algorithm

Directory of Open Access Journals (Sweden)

Yingsong Li

2014-01-01

Full Text Available We propose an lp-norm-penalized affine projection algorithm (LP-APA for broadband multipath adaptive channel estimations. The proposed LP-APA is realized by incorporating an lp-norm into the cost function of the conventional affine projection algorithm (APA to exploit the sparsity property of the broadband wireless multipath channel, by which the convergence speed and steady-state performance of the APA are significantly improved. The implementation of the LP-APA is equivalent to adding a zero attractor to its iterations. The simulation results, which are obtained from a sparse channel estimation, demonstrate that the proposed LP-APA can efficiently improve channel estimation performance in terms of both the convergence speed and steady-state performance when the channel is exactly sparse.

LEP dominates LP-HEP

International Nuclear Information System (INIS)

Fraser, Gordon

1991-01-01

CERN's LEP electron-positron collider was the star of this year's major physics meeting - the Joint International Lepton-Photon Symposium and Europhysics Conference on High Energy Physics (LP-HEP) - held in Geneva from 25 July - 1 August

Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life.

Science.gov (United States)

Tarry-Adkins, Jane L; Chen, Jian-Hua; Jones, Richard H; Smith, Noel H; Ozanne, Susan E

2010-08-01

Low birth weight is associated with glucose intolerance, insulin resistance, and type 2 diabetes (T2D) in later life. Good evidence indicates that the environment plays an important role in this relationship. However, the mechanisms underlying these relationships are defined poorly. Islets are particularly susceptible to oxidative stress, and this condition combined with fibrosis is thought to be instrumental in T2D pathogenesis. Here we use our maternal low-protein (LP) rat model to determine the effect of early diet on oxidative stress and fibrosis in pancreatic islets of male offspring at 3 and 15 mo of age. Islet xanthine oxidase (XO) expression was increased in 15-mo LP offspring, which suggests increased oxidative-stress. Manganese superoxide-dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and heme oxygenase-1 (HO-1) (antioxidant enzymes) were reduced significantly in LP offspring, which indicated impairment of oxidative defense. Expression of fibrosis markers collagen I and collagen III also increased in 15-mo LP offspring. Angiotensin II receptor type I (AT(II)R(1)), induced by hyperglycemia and oxidative-stress, was significantly up-regulated in 15-mo LP offspring. Lipid peroxidation was also increased in 15-mo LP animals. We conclude that maternal protein restriction causes age-associated increased oxidative stress, impairment of oxidative defense, and fibrosis. These findings provide mechanisms by which suboptimal early nutrition can lead to T2D development later in life.

PuLP/XtraPuLP : Partitioning Tools for Extreme-Scale Graphs

Energy Technology Data Exchange (ETDEWEB)

2017-09-21

PuLP/XtraPulp is software for partitioning graphs from several real-world problems. Graphs occur in several places in real world from road networks, social networks and scientific simulations. For efficient parallel processing these graphs have to be partitioned (split) with respect to metrics such as computation and communication costs. Our software allows such partitioning for massive graphs.

CORN, LP Goldfield Approval

Science.gov (United States)

This November 19, 2015 letter from EPA approves the petition from CORN, LP, Goldfield facility, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS pro

75 FR 38514 - Application to Export Electric Energy; Brookfield Energy Marketing LP

Science.gov (United States)

2010-07-02

... Energy Marketing LP AGENCY: Office of Electricity Delivery and Energy Reliability, DOE. ACTION: Notice of application. SUMMARY: Brookfield Energy Marketing LP (BEM LP) has applied for authority to transmit electric... surplus energy purchased from electric utilities, Federal power marketing agencies and other entities...

Strategic Framework for the Defense Acquisition System Understanding Defense Consolidation

National Research Council Canada - National Science Library

Potts, Anthony W

2007-01-01

The 1993 policy to promote the consolidation of the United States defense industry began a series of acquisitions and mergers that went beyond the intent of the policy and left the Department of Defense (DoD...

Online lektiehjælp

DEFF Research Database (Denmark)

Hansen, Jens Jørgen; Remvig, Kirstin

2016-01-01

vejledningsdidaktik, herunder metoder, modeller og materialer for lektievejledning i regi af Lektier Online. Lektier Online er en organisation ved Statsbiblioteket i Århus, der tilbyder en online lektiecafe, hvor bl.a. gymnasie-elever kan få hjælp af frivillige universitetsstuderende. Dette didaktiske de-sign er et...

2-LP mode few-mode fiber amplifier employing ring-core erbium-doped fiber.

Science.gov (United States)

Ono, Hirotaka; Hosokawa, Tsukasa; Ichii, Kentaro; Matsuo, Shoichiro; Nasu, Hitoshi; Yamada, Makoto

2015-10-19

A fiber amplifier supporting 2 LP modes that employs a ring-core erbium-doped fiber (RC-EDF) is investigated to reduce differential modal gain (DMG). The inner and outer radii of the ring-core of the RC-EDF are clarified for 2-LP mode operation of the amplifier, and are optimized to reduce the DMG. It is shown that using the overlap integral between the erbium-doped core area and the signal power mode distribution is a good way to optimize the inner and outer radii of the ring-core of the RC-EDF and thus minimize the DMG. A fabricated RC-EDF and a constructed 2-LP mode EDFA are described and a small DMG of around 1 dB is realized for LP01, LP11 and LP21 pumping.

LpMab-23: A Cancer-Specific Monoclonal Antibody Against Human Podoplanin.

Science.gov (United States)

Yamada, Shinji; Ogasawara, Satoshi; Kaneko, Mika K; Kato, Yukinari

2017-04-01

Human podoplanin (hPDPN), the ligand of C-type lectin-like receptor-2, is involved in cancer metastasis. Until now, many monoclonal antibodies (mAbs) have been established against hPDPN. However, it is still difficult to develop a cancer-specific mAb (CasMab) against hPDPN because the protein sequence of hPDPN expressed in cancer cells is the same as that in normal cells. Herein, we report LpMab-23 of the mouse IgG 1 subclass, a novel CasMab against hPDPN. In an immunohistochemical analysis, LpMab-23 reacted with tumor cells of human oral cancer, but did not react with normal cells such as lymphatic endothelial cells (LECs). In contrast, LpMab-17, another anti-hPDPN mAb, reacted with both tumor cells and LECs. Furthermore, flow cytometric analysis revealed that LpMab-23 reacted with hPDPN-expressing cancer cell lines (LN319, RERF-LC-AI/hPDPN, Y-MESO-14/hPDPN, and HSC3/hPDPN) but showed little reaction with normal cells (LECs and HEK-293T), although another anti-hPDPN mAb, LpMab-7, reacted with both hPDPN-expressing cancer cells and normal cells, indicating that LpMab-23 is a CasMab against hPDPN.

The Budget of the United States Government. Department of Defense Extract for Fiscal Years 1990 and 1991

Science.gov (United States)

1988-01-01

8217110) pO : 1 0) @! lp C0)" cQ. cJ clj(% (% CZ.J c ’) m ’. c ’ (" Cv . 00 C=) c’) c" C4 J * n C" 0 OR CR D (’ Rcp .4 Ile V! C’J a: U) @0 C’ ’t cr 46 L...corrections; (3) a special outlier policy SEC. [808,7] S061!. Not to exceed $35.000,000 of the funds available for children’s hospitals and neonatal ...Continental United States, including design, architecture, and engi- 20580 (June 3, 1988); (4) a refinement to the DRGs for neonatal nearing services

LibraryH3lp: A New Flexible Chat Reference System

Directory of Open Access Journals (Sweden)

Pam Sessoms

2008-09-01

Full Text Available LibraryH3lp is an integrated IM and web chat system designed specifically for Virtual Reference services in libraries. The software was designed for, and is currently used by, a night-time chat reference collaboraton between several large academic libraries. LibraryH3lp is designed for the workflow of chat reference, supporting multiple simultaneous operators and routing to queues of operators in a particular service area. It also supports web page embeddable chat 'widgets', as well as simultaneous gateways to multiple IM protocols. This article discusses the motivation for the development of the software, and provides an overview of LibraryH3lp's features and technical architecture. Parts of LibraryH3lp are available as open source. The complete application is available as a low-cost hosted service, and will eventually be available to be licensed for local hosting.

France, Germany, Greece and the United Kingdom an analysis and comparison of budget deficits and defense spending

OpenAIRE

Schoettelndreyer, Friedrich.

2011-01-01

Approved for public release; distribution is unlimited. This thesis documents findings on the relationship of government budget deficits and defense spending for France, Germany, Greece, and the United Kingdom in detail and for NATO and OECD country collectives. The thesis topic is relevant, as many European countries are justifying their recent cuts in defense spending with high government budget deficits. The author looked at different data sources and metrics to graphically analyze the ...

76 FR 49760 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2011-08-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-524-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on July 29, 2011, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056-5310, filed with the Federal Energy...

76 FR 7833 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2011-02-11

...] Texas Eastern Transmission, LP; Notice of Application Take notice that on January 25, 2011, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in the above... TEAM 2012 Project. Specifically, Texas Eastern requests: (i) Authorization under NGA sections 7(b) and...

New low pressure (LP) turbines for NE Krsko

International Nuclear Information System (INIS)

Nemcic, K.; Novsak, M.

2004-01-01

During the evaluation of possible future maintenance strategies on steam turbine in very short period of time, engineering decision was made by NE Krsko in agreement with Owners to replace the existing two Low Pressure (LP) Turbines with new upgrading LP Turbines. This decision is presented with review of the various steam turbine problems as: SCC on turbine discs; blades cracking; erosion-corrosion with comparison of various maintenance options and efforts undertaken by the NE Krsko to improve performance of the original low pressure turbines. This paper presents the NEK approach to solve the possible future problems with steam turbine operation in NE Krsko as pro-active engineering and maintenance activities on the steam turbine. This paper also presents improvements involving retrofits, confined to the main steam turbine path, with major differences between original and new LP Turbines as beneficial replacement because of turbine MWe upgrading and return capital expenditures.(author)

The role of LP gas in eradicating energy poverty

Energy Technology Data Exchange (ETDEWEB)

Kelly, Michael; Behuria, Sarthak

2010-09-15

LP Gas is an ideal solution for dealing with energy poverty. Clean burning, low carbon, extremely efficient, requiring minimal infrastructure or R and D investment and with plentiful long term global supply, LP Gas can be quickly introduced to play an important role in eradicating energy poverty and steering both industrialised and developing countries onto more sustainable energy development paths.

78 FR 43874 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2013-07-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP13-514-000] Texas Eastern Transmission, LP; Notice of Application On July 2, 2013, Texas Eastern Transmission, LP (Texas Eastern) filed... natural gas facilities no longer in service. As described more fully in the Application, Texas Eastern...

76 FR 38381 - Texas Eastern Transmission, LP; Notice of Amendment

Science.gov (United States)

2011-06-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-67-001] Texas Eastern Transmission, LP; Notice of Amendment Take notice that on June 13, 2011, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in the above referenced docket an amendment...

77 FR 20015 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2012-04-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-88-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on March 19, 2012, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056-5310, filed an application in Docket No...

77 FR 12045 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2012-02-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-68-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on February 16, 2012, Texas Eastern Transmission, LP (Texas Eastern), PO Box 1642, Houston, Texas 77056 filed an application in the above referenced docket...

78 FR 32294 - DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02...

Science.gov (United States)

2013-05-29

... Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of a... SMALL BUSINESS ADMINISTRATION DeltaPoint Capital IV, L.P., DeltaPoint Capital IV (New York), L.P., License No. 02/02-0662,02/02-0661; Notice Seeking Exemption Under Section 312 of the Small Business...

78 FR 66352 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2013-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-9-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on October 17, 2013, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed an application in Docket No. CP14-9...

78 FR 79687 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2013-12-31

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-29-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on December 10, 2013 Texas Eastern Transmission, LP (Texas Eastern), at 5400 Westheimer Court, Houston, Texas 77056, filed an application in Docket No. CP14...

77 FR 26534 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2012-05-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-164-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on April 19, 2012, Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in Docket No. CP12-164-000, a request...

Significance of Lipiodol-CT in the evaluation of therapeutic effects of Lp-TAE for hepatocellular carcinoma

International Nuclear Information System (INIS)

Jinno, Kenji; Tokuyama, Katuyuki; Yumoto, Yasuhiro

1988-01-01

In 20 lesions of 17 patients treated with arterial infusion of SMANCS dissolved in lipiodol (Lp) and transcatheter arterial embolization (TAE) for hepatocellular carcinoma (HCC), Lp deposition within the tumor were depicted on CT (Lp-CT). The findings of Lp-CT were compared with those of macroscopic, soft X-ray, and histologic examinations for resected specimens. Lp-CT appearance of HCC fell into four types: (I) complete type - round and homogeneous high density area (HDA) - in which Lp was deposited over the whole area; (II) defective type - inhomogeneous HDA - in which Lp was deposited in part of the tumor; (III) aggregated type - aggregation of small HDA; (IV) deficient type - no HDA - in which little or no Lp was deposited. Type I was found in 20 % of the lesions, type II in 25 %, type III in 20 %, and type IV in 35 %. In type I, HCC was of macroscopically nodular form with expansive growth and pseudocapsule and of histologically trabecular form with broad blood spaces and inviable cancer cells. In the other types, similar findings were seen in the necrotic area in which Lp was deposited, whereas scirrhous or compact type of HCC was histologically seen in the area containing viable cancer cells in which no Lp was deposited. The presence or not of Lp deposition, as depicted on CT, was closely correlated with histologic findings, which has significant implications for the evaluation of therapeutic efficacy of TAE with Lp. (Namekawa, K.)

78 FR 11567 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2013-02-19

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39...

76 FR 70040 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2011-11-10

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (type certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and... new AD: 2011-23-07 Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft...

On $L_p$ Affine Surface Area and Curvature Measures

OpenAIRE

Zhao, Yiming

2015-01-01

The relationship between $L_p$ affine surface area and curvature measures is investigated. As a result, a new representation of the existing notion of $L_p$ affine surface area depending only on curvature measures is derived. Direct proofs of the equivalence between this new representation and those previously known are provided. The proofs show that the new representation is, in a sense, "polar" to that of Lutwak's and "dual" to that of Sch\\"utt & Werner's.

A New Algorithm for Detecting Cloud Height using OMPS/LP Measurements

Science.gov (United States)

Chen, Zhong; DeLand, Matthew; Bhartia, Pawan K.

2016-01-01

The Ozone Mapping and Profiler Suite Limb Profiler (OMPS/LP) ozone product requires the determination of cloud height for each event to establish the lower boundary of the profile for the retrieval algorithm. We have created a revised cloud detection algorithm for LP measurements that uses the spectral dependence of the vertical gradient in radiance between two wavelengths in the visible and near-IR spectral regions. This approach provides better discrimination between clouds and aerosols than results obtained using a single wavelength. Observed LP cloud height values show good agreement with coincident Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) measurements.

United States Coast Guard Antisubmarine Warfare (ASW) in the Maritime Defense Zone (MDZ) - A Strategic Approach

Science.gov (United States)

1989-03-01

RIC ILE COPY AIR WAR COLLGE REEAC R~pCR UNITED STATES COAST GUARD ANTISUBMARINE WARFARE (ASW) IN THE MARITIME DEFENSE ZONE (MDZ) -A STRATEGIC...going to perform in these MDZs. Those tasks identified so far include: port and coastal physical security & preventive safety, mine warfare

Amplitude and Recurrence Time of LP activity at Mt. Etna, Italy

Science.gov (United States)

Cauchie, Léna; Saccorotti, Gilberto; Bean, Christopher

2013-04-01

The manifestation of Long-Period (LP) activity is attested on many volcanoes worldwide and is thought to be associated with the resonant oscillations of subsurface, fluid-filled, cracks and conduits. Nonetheless the actual source mechanism that originates the resonance is still unclear. Different models have been proposed so far, including (i) fluid flow instabilities as periodic degassing and (ii) brittle failure in viscous magmas. Since LP activity usually precedes and accompanies volcanic eruption, the understanding of these sources is crucial for the hazard assessment and eruption early warning. The work is aimed at improving the understanding of the LP source mechanism through a statistical analysis of detailed LP catalogues. The behaviour of LP activity is compared with the empirical laws governing earthquakes recurrence (e.g., Gutenberg-Richter [GR] and Gamma-law distributions), in order to understand what relationships, if any, exist between these two apparently different earthquake classes. In particular, about 13000 events were detected on Mount Etna in August 2005 through a STA/LTA method. For this given period, the volcano does not present particular sign of unrest. The manifestation of the LP events is sustained in time over all the period of analysis. From the analysis of the directional properties, it turns out that the events of this first catalog propagate from 2 distinct sources . Furthermore, the events exhibit a high degree of waveform similarity, and provide a criterion for classification/source separation. The events were then grouped into families of comparable waveforms, resulting also in a separation for their source locations. We then used template signals of each family for a Matched-Filtering of the continuous data streams, in order to discriminate small-amplitude events previously undetected by the STA/LTA triggering method. This procedure allowed for a significant enrichment of the catalogues. The retrieved amplitude distributions

78 FR 69078 - Houston Pipe Line Company LP; Notice of Application

Science.gov (United States)

2013-11-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-13-000] Houston Pipe Line Company LP; Notice of Application Take notice that on October 28, 2013, Houston Pipe Line Company LP (HPL), 1300 Main Street, Houston, Texas 77002, filed an application in Docket No. CP14-13-000...

Diagnostic value of CRP and Lp(a) in coronary heart disease.

Science.gov (United States)

Erbağci, Ayşe Binnur; Tarakçioğlu, Mehmet; Aksoy, Mehmet; Kocabaş, Ramazan; Nacak, Muradiye; Aynacioğlu, A Sükrü; Sivrikoz, Cumhur

2002-06-01

Increased lipoprotein (a) [Lp(a)] concentration was reported to be an independent risk factor for coronary heart disease (CHD). Recent epidemiological studies affirmed the value of C-reactive protein (CRP) as the strongest, univariate predictor of the cardiovascular events. We decided to establish cut-off levels providing maximum diagnostic efficiency for CHD. In this study we measured CRP and Lp(a) concentrations in patients with angiographically demonstrated CHD (group A, n: 120), patients without any angiographically demonstrable lesion (group B, n: 62) and a group of healthy subjects (group C, n: 41). Data were evaluated correcting for lipid and lipoprotein concentrations, diabetes mellitus, hypertension, smoking, age, and body mass index in men and women. ROC curve based cut-off values (comparing group A versus groups B and C) and associated diagnostic performances of the assays were evaluated. Significant increases were noted in serum CRP concentrations in men and women, in groups A vs. B,A vs. C, B vs. C. Lp(a) concentrations were not different among groups in men but were higher in group A vs. B and C in women. Optimal cut-off levels for CRP in women and men were found as 2.1 and 3.0 mg/l with the diagnostic values of 0.792 and 0.770, respectively. For Lp(a) optimal cut-off levels were found as 22.6 and 9.8 mg/dl with the diagnostic values of 0.612 and 0.596 in women and men, respectively. The CRP level is quite efficient for separation of patients from controls. Therefore keeping in mind the lack of specificity, the CRP level may be a useful tool in the diagnosis of coronary heart disease. However, the Lp(a) level is not efficient enough to support the use of Lp(a) measurement for management of coronary heart disease.

Analysis of error floor of LDPC codes under LP decoding over the BSC

Energy Technology Data Exchange (ETDEWEB)

Chertkov, Michael [Los Alamos National Laboratory; Chilappagari, Shashi [UNIV OF AZ; Vasic, Bane [UNIV OF AZ; Stepanov, Mikhail [UNIV OF AZ

2009-01-01

We consider linear programming (LP) decoding of a fixed low-density parity-check (LDPC) code over the binary symmetric channel (BSC). The LP decoder fails when it outputs a pseudo-codeword which is not a codeword. We propose an efficient algorithm termed the instanton search algorithm (ISA) which, given a random input, generates a set of flips called the BSC-instanton and prove that: (a) the LP decoder fails for any set of flips with support vector including an instanton; (b) for any input, the algorithm outputs an instanton in the number of steps upper-bounded by twice the number of flips in the input. We obtain the number of unique instantons of different sizes by running the ISA sufficient number of times. We then use the instanton statistics to predict the performance of the LP decoding over the BSC in the error floor region. We also propose an efficient semi-analytical method to predict the performance of LP decoding over a large range of transition probabilities of the BSC.

Plasma Lp-PLA2 mass and apoB-lipoproteins that carry Lp-PLA2 decrease after sodium

NARCIS (Netherlands)

Constantinides, Alexander; Kerstens, Michiel N.; Dikkeschei, Bert D.; van Pelt, L. Joost; Tellis, Constantinos C.; Tselepis, Alexandros D.; Dullaart, Robin P. F.

2012-01-01

Eur J Clin Invest 2012; 42 (11): 12351243 Abstract Background Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel cardiovascular risk marker, which is predominantly complexed to apolipoprotein (apo) B-containing lipoproteins in human plasma. As increasing dietary sodium intake may decrease

Strategic Missile Defense & Nuclear Deterrence

Science.gov (United States)

Grego, Laura

The United States has pursued defenses against nuclear-armed long-range ballistic missiles since at least the 1950s. At the same time, concerns that missile defenses could undermine nuclear deterrence and potentially spark an arms race led the United States and Soviet Union to negotiate limits on these systems. The 1972 Anti-Ballistic Missile Treaty constrained strategic missile defenses for thirty years. After abandoning the treaty in 2002, President George W. Bush began fielding the Ground-based Midcourse Defense (GMD) homeland missile defense system on an extremely aggressive schedule, nominally to respond to threats from North Korea and Iran. Today, nearly fifteen years after its initial deployment, the potential and the limits of this homeland missile defense are apparent. Its test record is poor and it has no demonstrated ability to stop an incoming missile under real-world conditions. No credible strategy is in place to solve the issue of discriminating countermeasures. Insufficient oversight has not only exacerbated the GMD system's problems, but has obscured their full extent, which could encourage politicians and military leaders to make decisions that actually increase the risk of a missile attack against the United States. These are not the only costs. Both Russia and China have repeatedly expressed concerns that U.S. missile defenses adversely affect their own strategic capabilities and interests, particularly taken in light of the substantial US nuclear forces. This in turn affects these countries' nuclear modernization priorities. This talk will provide a technical overview of the US strategic missile defense system, and how it relates to deterrence against non-peer adversaries as well as how it affects deterrence with Russia and China and the long-term prospects for nuclear reductions

Convex Hypersurfaces and $L^p$ Estimates for Schr\\"odinger Equations

OpenAIRE

Zheng, Quan; Yao, Xiaohua; Fan, Da

2004-01-01

This paper is concerned with Schr\\"odinger equations whose principal operators are homogeneous elliptic. When the corresponding level hypersurface is convex, we show the $L^p$-$L^q$ estimate of solution operator in free case. This estimate, combining with the results of fractionally integrated groups, allows us to further obtain the $L^p$ estimate of solutions for the initial data belonging to a dense subset of $L^p$ in the case of integrable potentials.

Immunogenicity, Safety, and Tolerability of Bivalent rLP2086 Meningococcal Group B Vaccine Administered Concomitantly With Diphtheria, Tetanus, and Acellular Pertussis and Inactivated Poliomyelitis Vaccines to Healthy Adolescents.

Science.gov (United States)

Vesikari, Timo; Wysocki, Jacek; Beeslaar, Johannes; Eiden, Joseph; Jiang, Qin; Jansen, Kathrin U; Jones, Thomas R; Harris, Shannon L; O'Neill, Robert E; York, Laura J; Perez, John L

2016-06-01

Concomitant administration of bivalent rLP2086 (Trumenba [Pfizer, Inc] and diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine (DTaP/IPV) was immunologically noninferior to DTaP/IPV and saline and was safe and well tolerated. Bivalent rLP2086 elicited robust and broad bactericidal antibody responses to diverse Neisseria meningitidis serogroup B strains expressing antigens heterologous to vaccine antigens after 2 and 3 vaccinations. Bivalent rLP2086, a Neisseria meningitidis serogroup B (MnB) vaccine (Trumenba [Pfizer, Inc]) recently approved in the United States to prevent invasive MnB disease in individuals aged 10-25 years, contains recombinant subfamily A and B factor H binding proteins (fHBPs). This study evaluated the coadministration of Repevax (diphtheria, tetanus, and acellular pertussis and inactivated poliovirus vaccine [DTaP/IPV]) (Sanofi Pasteur MSD, Ltd) and bivalent rLP2086. Healthy adolescents aged ≥11 to B proteins different from the vaccine antigens. Participants were randomly assigned to receive bivalent rLP2086 + DTaP/IPV (n = 373) or saline + DTaP/IPV (n = 376). Immune responses to DTaP/IPV in participants who received bivalent rLP2086 + DTaP/IPV were noninferior to those in participants who received saline + DTaP/IPV.The proportions of bivalent rLP2086 + DTaP/IPV recipients with prespecified seroprotective hSBA titers to the 4 MnB test strains were 55.5%-97.3% after vaccination 2 and 81.5%-100% after vaccination 3. The administration of bivalent rLP2086 was well tolerated and resulted in few serious adverse events. Immune responses to DTaP/IPV administered with bivalent rLP2086 to adolescents were noninferior to DTaP/IPV administered alone. Bivalent rLP2086 was well tolerated and elicited substantial and broad bactericidal responses to diverse MnB strains in a high proportion of recipients after 2 vaccinations, and these responses were further enhanced after 3 vaccinations.ClinicalTrials.gov identifier NCT01323270

A spinach O-acetylserine(thiollyase homologue, SoCSaseLP, suppresses cysteine biosynthesis catalysed by other enzyme isoforms

Directory of Open Access Journals (Sweden)

Miki Noda

2016-06-01

Full Text Available An enzyme, O-acetylserine(thiollyase (OASTL, also known as O-acetylserine sulfhydrylase or cysteine synthase (CSase, catalyses the incorporation of sulfide into O-acetylserine and produces cysteine. We previously identified a cDNA encoding an OASTL-like protein from Spinacia oleracea, (SoCSaseLP, but a recombinant SoCSaseLP produced in Escherichia coli did not show OASTL activity. The exon-intron structure of the SoCSaseLP gene shared conserved structures with other spinach OASTL genes. The SoCSaseLP and a Beta vulgaris homologue protein, KMT13462, comprise a unique clade in the phylogenetic tree of the OASTL family. Interestingly, when the SoCSaseLP gene was expressed in tobacco plants, total OASTL activity in tobacco leaves was reduced. This reduction in total OASTL activity was most likely caused by interference by SoCSaseLP with cytosolic OASTL. To investigate the possible interaction of SoCSaseLP with a spinach cytosolic OASTL isoform SoCSaseA, a pull-down assay was carried out. The recombinant glutathione S-transferase (GST-SoCSaseLP fusion protein was expressed in E. coli together with the histidine-tagged SoCSaseA protein, and the protein extract was subjected to glutathione affinity chromatography. The histidine-tagged SoCSaseA was co-purified with the GST-SoCSaseLP fusion protein, indicating the binding of SoCSaseLP to SoCSaseA. Consistent with this interaction, the OASTL activity of the co-purified SoCSaseA was reduced compared with the activity of SoCSaseA that was purified on its own. These results strongly suggest that SoCSaseLP negatively regulates the activity of other cytosolic OASTL family members by direct interaction.

LP (a) levels and apo (a) phenotypes in urban black South African ...

African Journals Online (AJOL)

300 U/I), intermediate (300 - 700 UII) and high (> 700 UII) plasma Lp (a) ... Tygerberg Hospital, Tygerberg, W Cape ... up to 200-fold difference in Lp (a) concentrations.' In addition, ethnic .... An interesting observation was the large number of phenotypes, Le. ... sample of black Americans with a high-resolution SOS- agarose ...

LP 543-25: A Rare Low-mass Runaway Disk Star

Science.gov (United States)

de la Fuente Marcos, Raúl; de la Fuente Marcos, Carlos

2018-05-01

LP 543-25 or PSS 544-7 is a high proper-motion star located 458 pc from the Sun in the constellation of Canis Minor; it has been argued that it could be a candidate cannonball star ejected by a star cluster. Here, we revisit the issue of the kinematics of this interesting star using Gaia DR2. The heliocentric Galactic velocity components are (U, V, W) = (206, -289, 30) km/s; the corresponding Galactocentric Galactic velocity components show that LP 543-25 is moving in the Galactic plane and away from the Galactic Center at a rate of nearly 200 km/s, which is compatible with an origin in one of the multiple star clusters that inhabit the inner regions of the Milky Way. LP 543-25 appears to be a member of an elusive class of stars, the low-mass runaway stars. It is perhaps one of the closest and less massive runaway stars identified so far.

65 nm LP/GP mix low cost platform for multi-media wireless and consumer applications

Science.gov (United States)

Tavel, B.; Duriez, B.; Gwoziecki, R.; Basso, M. T.; Julien, C.; Ortolland, C.; Laplanche, Y.; Fox, R.; Sabouret, E.; Detcheverry, C.; Boeuf, F.; Morin, P.; Barge, D.; Bidaud, M.; Biénacel, J.; Garnier, P.; Cooper, K.; Chapon, J. D.; Trouiller, Y.; Belledent, J.; Broekaart, M.; Gouraud, P.; Denais, M.; Huard, V.; Rochereau, K.; Difrenza, R.; Planes, N.; Marin, M.; Boret, S.; Gloria, D.; Vanbergue, S.; Abramowitz, P.; Vishnubhotla, L.; Reber, D.; Stolk, P.; Woo, M.; Arnaud, F.

2006-04-01

A complete 65 nm CMOS platform, called LP/GP Mix, has been developed employing thick oxide transistor (IO), Low Power (LP) and General Purpose (GP) devices on the same chip. Dedicated to wireless multi-media and consumer applications, this new triple gate oxide platform is low cost (+1mask only) and saves over 35% of dynamic power with the use of the low operating voltage GP. The LP/GP mix shows competitive digital performance with a ring oscillator (FO = 1) speed equal to 7 ps per stage (GP) and 6T-SRAM static power lower than 10 pA/cell (LP). Compatible with mixed-signal design requirements, transistors show high voltage gain, low mismatch factor and low flicker noise. Moreover, to address mobile phone demands, excellent RF performance has been achieved with FT = 160 GHz for LP and 280 GHz for GP nMOS transistors.

Capped Lp approximations for the composite L0 regularization problem

OpenAIRE

Li, Qia; Zhang, Na

2017-01-01

The composite L0 function serves as a sparse regularizer in many applications. The algorithmic difficulty caused by the composite L0 regularization (the L0 norm composed with a linear mapping) is usually bypassed through approximating the L0 norm. We consider in this paper capped Lp approximations with $p>0$ for the composite L0 regularization problem. For each $p>0$, the capped Lp function converges to the L0 norm pointwisely as the approximation parameter tends to infinity. We point out tha...

Survival associated pathway identification with group Lp penalized global AUC maximization

Directory of Open Access Journals (Sweden)

Liu Zhenqiu

2010-08-01

Full Text Available Abstract It has been demonstrated that genes in a cell do not act independently. They interact with one another to complete certain biological processes or to implement certain molecular functions. How to incorporate biological pathways or functional groups into the model and identify survival associated gene pathways is still a challenging problem. In this paper, we propose a novel iterative gradient based method for survival analysis with group Lp penalized global AUC summary maximization. Unlike LASSO, Lp (p 1. We first extend Lp for individual gene identification to group Lp penalty for pathway selection, and then develop a novel iterative gradient algorithm for penalized global AUC summary maximization (IGGAUCS. This method incorporates the genetic pathways into global AUC summary maximization and identifies survival associated pathways instead of individual genes. The tuning parameters are determined using 10-fold cross validation with training data only. The prediction performance is evaluated using test data. We apply the proposed method to survival outcome analysis with gene expression profile and identify multiple pathways simultaneously. Experimental results with simulation and gene expression data demonstrate that the proposed procedures can be used for identifying important biological pathways that are related to survival phenotype and for building a parsimonious model for predicting the survival times.

Joint-Service Integration: An Organizational Culture Study of the United States Department of Defense Voluntary Education System

Science.gov (United States)

Benson, Martin K.

2010-01-01

The purpose of the descriptive case study with a multiple case framework was to (a) describe the organizational cultures of education programs and leaders in the United States (U.S.) Department of Defense (DoD) voluntary education system on Oahu, Hawaii; (b) determine if an overlapping common organizational culture exists; and (c) assess the…

State of the Art in LP-WAN Solutions for Industrial IoT Services.

Science.gov (United States)

Sanchez-Iborra, Ramon; Cano, Maria-Dolores

2016-05-17

The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN), is explored. By means of a cellular-type architecture, LP-WAN-based solutions aim at fulfilling the reliability and efficiency challenges posed by long-term industrial networks. Thus, the most prominent LP-WAN solutions are reviewed, identifying and discussing the pros and cons of each of them. The focus is also on examining the current deployment state of these platforms in Spain. Although LP-WAN systems are at early stages of development, they represent a promising alternative for boosting future industrial IIoT (Industrial Internet of Things) networks and services.

State of the Art in LP-WAN Solutions for Industrial IoT Services

Directory of Open Access Journals (Sweden)

Ramon Sanchez-Iborra

2016-05-01

Full Text Available The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN, is explored. By means of a cellular-type architecture, LP-WAN–based solutions aim at fulfilling the reliability and efficiency challenges posed by long-term industrial networks. Thus, the most prominent LP-WAN solutions are reviewed, identifying and discussing the pros and cons of each of them. The focus is also on examining the current deployment state of these platforms in Spain. Although LP-WAN systems are at early stages of development, they represent a promising alternative for boosting future industrial IIoT (Industrial Internet of Things networks and services.

Circulating and PBMC Lp-PLA2 associate differently with oxidative stress and subclinical inflammation in nonobese women (menopausal status.

Directory of Open Access Journals (Sweden)

Jean Kyung Paik

Full Text Available BACKGROUND: This study aimed to determine the association of lipoprotein-associated phospholipase A(2 (Lp-PLA(2 activity in circulation and peripheral blood mononuclear cells (PBMCs with inflammatory and oxidative stress markers in nonobese women and according to menopausal status. Lp-PLA(2 activity, a marker for cardiovascular risk is associated with inflammation and oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: Eighty postmenopausal women (53.0±4.05 yr and 96 premenopausal women (39.7±9.25 yr participated in this study. Lp-PLA(2 activities, interleukin (IL-6, tumor necrosis factor (TNF-α, and IL-1β in plasma as well as in PBMCs were measured. Plasma ox-LDL was also measured. Postmenopausal women demonstrated higher circulating levels of ox-LDL and IL-6, as well as IL-6, TNF-α, and IL-1β in PBMCs, than premenopausal women. In both groups, plasma Lp-PLA(2 activity positively correlated with Lp-PLA(2 activity in PBMCs and plasma ox-LDL. In premenopausal women, Lp-PLA(2 activities in plasma and PBMCs positively correlated with IL-6, TNF-α, and IL-1β in PBMCs. In postmenopausal women, plasma ox-LDL positively correlated with PBMC cytokine production. In subgroup analysis of postmenopausal women according to plasma ox-LDL level (median level: 48.715 U/L, a significant increase in Lp-PLA(2 activity in the plasma but not the PBMCs was found in the high ox-LDL subgroup. Plasma Lp-PLA(2 activity positively correlated with unstimulated PBMC Lp-PLA(2 activity in the low ox-LDL subgroup (r = 0.627, P<0.001, whereas in the high ox-LDL circulating Lp-PLA(2 activity positively correlated with plasma ox-LDL (r = 0.390, P = 0.014 but not with Lp-PLA(2 activity in PBMCs. CONCLUSIONS/SIGNIFICANCE: The lack of relation between circulating Lp-PLA(2 activity and Lp-PLA(2 activity in PBMCs was found in postmenopausal women with high ox-LDL. This may indicate other sources of circulating Lp-PLA(2 activity except PBMC in postmenopausal women

An LP-based heuristic for the fixed charge transportation problem

DEFF Research Database (Denmark)

Klose, Andreas

2007-01-01

The fixed charge transportation problem consists in finding a minimum cost network flow from a set of suppliers to a set of customers. Beside costs proportional to quantities transported, transportation costs also include a fixed charge. The paper describes a linear programming based heuristic...... approach for computing lower and upper bounds on the minimal cost. To this end, the LP relaxation is iteratively strengthened by means of adding cuts; in each iteration the current LP solution is then used to guide a local search heuristic. In addition to standard polyhedral cuts as lifted cover...

78 FR 62614 - Guttman Energy, Inc., PBF Holding Company LLC v. Buckeye Pipe Line Company, L.P., Laurel Pipe...

Science.gov (United States)

2013-10-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. OR14-4-000] Guttman Energy, Inc., PBF Holding Company LLC v. Buckeye Pipe Line Company, L.P., Laurel Pipe Line Company, L.P... complaint against Buckeye Pipe Line Company L.P. and Laurel Pipe Line Company L.P. (Respondents) challenging...

Child Advocacy in the United States: The Work of the Children's Defense Fund. Innocenti Essays No. 2.

Science.gov (United States)

Weill, James D.

This essay provides an overview of the goals and activities of the Children's Defense Fund (CDF), an advocacy group headquartered in Washington, D.C. that works to improve the well-being of American children through systemic change and whose goal is to make it unacceptable for any child in the United States to grow up homeless, hungry, sick,…

76 FR 29234 - Texas Eastern Transmission, LP; Notice of Request Under Blanket Authorization

Science.gov (United States)

2011-05-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-477-000] Texas Eastern Transmission, LP; Notice of Request Under Blanket Authorization Take notice that on May 10, 2011 Texas Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in Docket No. CP11-477-000...

Advanced LP turbine installation at 1300 MW nuclear power station Unterweser

International Nuclear Information System (INIS)

Jacobsen, G.; Oeynhausen, H.; Termuehlen, H.

1991-01-01

This paper reports on Preussen Elektra AG's Unterweser power plant. The steam turbine-generator features a disk-type LP turbine rotor design developed in the late 1960's to early 1970's. This rotor design has been installed in 19 nuclear power plants. The 47 rotors in these plants have been in operation for an average of almost 10 years. The design of the 1970 vintage nuclear LP turbine rotors was based on extensive experience gained with disk-type rotors of fossil turbines built in the 1950's. When EPRI reported about corrosion cracking in nuclear LP turbines, a program was initiated by Siemens/KWU as original steam turbine supplier to ultrasonically inspect all their disk-type rotors in nuclear power plats. Indications on one rotor disk in the Unterweser plant was found. This single event was the only one found out of 310 disks inspected in nuclear power plants

77 FR 64767 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2012-10-23

... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... airworthiness directive (AD) for certain Gulfstream Aerospace LP (Type Certificate previously held by Israel... Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes...

78 FR 47546 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2013-08-06

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model... Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli...

Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a levels in African Americans.

Directory of Open Access Journals (Sweden)

Rahul C Deo

2011-01-01

Full Text Available Lipoprotein(a (Lp(a is an important causal cardiovascular risk factor, with serum Lp(a levels predicting atherosclerotic heart disease and genetic determinants of Lp(a levels showing association with myocardial infarction. Lp(a levels vary widely between populations, with African-derived populations having nearly 2-fold higher Lp(a levels than European Americans. We investigated the genetic basis of this difference in 4464 African Americans from the Jackson Heart Study (JHS using a panel of up to 1447 ancestry informative markers, allowing us to accurately estimate the African ancestry proportion of each individual at each position in the genome. In an unbiased genome-wide admixture scan for frequency-differentiated genetic determinants of Lp(a level, we found a convincing peak (LOD = 13.6 at 6q25.3, which spans the LPA locus. Dense fine-mapping of the LPA locus identified a number of strongly associated, common biallelic SNPs, a subset of which can account for up to 7% of the variation in Lp(a level, as well as >70% of the African-European population differences in Lp(a level. We replicated the association of the most strongly associated SNP, rs9457951 (p = 6 × 10(-22, 27% change in Lp(a per allele, ∼5% of Lp(a variance explained in JHS, in 1,726 African Americans from the Dallas Heart Study and found an even stronger association after adjustment for the kringle(IV repeat copy number. Despite the strong association with Lp(a levels, we find no association of any LPA SNP with incident coronary heart disease in 3,225 African Americans from the Atherosclerosis Risk in Communities Study.

75 FR 28485 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2010-05-21

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39... previously held by Israel Aircraft Industries, Ltd.) Model Gulfstream 100 airplanes; and Model Astra SPX and...

Smell of danger: an analysis of LP-gas odorization

Energy Technology Data Exchange (ETDEWEB)

Cain, W.S.; Turk, A.

1985-03-01

LP-gas derives warning properties from the odorants ethyl mercaptan or thiophane. Laboratory tests have implied that the average person has the ability to smell the odors before leaking LP-gas reaches one-fifth its lower limit of flammability. Generally, however, laboratory tests ignore or discard persons with a poor sense of smell, especially the elderly and persons with certain types of hyposmia. Some persons who apparently can smell the warning agents when directed may otherwise fail to notice or identify them. Elderly men seem particularly vulnerable to instances of incidental anosmia and olfactory agnosia. Psychophysical testing of the warning agents has been rather unsophisticated. There exists neither a standard protocol for testing nor adequate specification of the perceptual properties that might make one warning agent better than another. Without such developments, improvement in warning agents will fail to occur. Possible improvements include increases in concentration, the use of blends to insure more uniform delivery of agent and, to decrease the perceptual vulnerability of relatively insensitive people, use of agents with favorable psychophysical (stimulus-response) functions and use of agents with favorable adaptation characteristics. Even without a change in existing products, it seems advisable to learn more about the vulnerability of LP-gas users and to employ educational means to reduce risks.

12 CFR 411.500 - Secretary of Defense.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Secretary of Defense. 411.500 Section 411.500 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES NEW RESTRICTIONS ON LOBBYING Exemptions § 411.500 Secretary of Defense. (a) The Secretary of Defense may exempt, on a case-by-case basis, a covered...

Comparative genome analysis of Lactobacillus plantarum GB-LP3 provides candidates of survival-related genetic factors.

Science.gov (United States)

Jeon, Soomin; Jung, Jaehoon; Kim, Kwondo; Yoo, DongAhn; Lee, Chanho; Kang, Jungsun; Cho, Kyungjin; Kang, Dae-Kyung; Kwak, Woori; Yoon, Sook Hee; Kim, Heebal; Cho, Seoae

2017-09-01

Lactobacillus plantarum is found in various environmental niches such as in the gastrointestinal tract of an animal host or a fermented food. This species isolated from a certain environment is known to possess a variety of properties according to inhabited environment's adaptation. However, a causal relationship of a genetic factor and phenotype affected by a specific environment has not been systematically comprehended. L. plantarum GB-LP3 strain was isolated from Korean traditional fermented vegetable and the whole genome of GB-LP3 was sequenced. Comparative genome analysis of GB-LP3, with other 14 L. plantarum strains, was conducted. In addition, genomic island regions were investigated. The assembled whole GB-LP3 genome contained a single circular chromosome of 3,206,111bp with the GC content of 44.7%. In the phylogenetic tree analysis, GB-LP3 was in the closest distance from ZJ316. The genomes of GB-LP3 and ZJ316 have the high level of synteny. Functional genes that are related to prophage, bacteriocin, and quorum sensing were found through comparative genomic analysis with ZJ316 and investigation of genomic islands. dN/dS analysis identified that the gene coding for phosphonate ABC transporter ATP-binding protein is evolutionarily accelerated in GB-LP3. Our study found that potential candidate genes that are affected by environmental adaptation in Korea traditional fermented vegetable. Copyright © 2017. Published by Elsevier B.V.

A new LP formulation of the admission control problem modelled as an MDP under average reward criterion

Science.gov (United States)

Pietrabissa, Antonio

2011-12-01

The admission control problem can be modelled as a Markov decision process (MDP) under the average cost criterion and formulated as a linear programming (LP) problem. The LP formulation is attractive in the present and future communication networks, which support an increasing number of classes of service, since it can be used to explicitly control class-level requirements, such as class blocking probabilities. On the other hand, the LP formulation suffers from scalability problems as the number C of classes increases. This article proposes a new LP formulation, which, even if it does not introduce any approximation, is much more scalable: the problem size reduction with respect to the standard LP formulation is O((C + 1)2/2 C ). Theoretical and numerical simulation results prove the effectiveness of the proposed approach.

Long Period (LP) volcanic earthquake source location at Merapi volcano by using dense array technics

Science.gov (United States)

Metaxian, Jean Philippe; Budi Santoso, Agus; Laurin, Antoine; Subandriyo, Subandriyo; Widyoyudo, Wiku; Arshab, Ghofar

2015-04-01

Since 2010, Merapi shows unusual activity compared to last decades. Powerful phreatic explosions are observed; some of them are preceded by LP signals. In the literature, LP seismicity is thought to be originated within the fluid, and therefore to be representative of the pressurization state of the volcano plumbing system. Another model suggests that LP events are caused by slow, quasi-brittle, low stress-drop failure driven by transient upper-edifice deformations. Knowledge of the spatial distribution of LP events is fundamental for better understanding the physical processes occurring in the conduit, as well as for the monitoring and the improvement of eruption forecasting. LP events recorded at Merapi have a spectral content dominated by frequencies between 0.8 and 3 Hz. To locate the source of these events, we installed a seismic antenna composed of 4 broadband CMG-6TD Güralp stations. This network has an aperture of 300 m. It is located on the site of Pasarbubar, between 500 and 800 m from the crater rim. Two multi-parameter stations (seismic, tiltmeter, S-P) located in the same area, equipped with broadband CMG-40T Güralp sensors may also be used to complete the data of the antenna. The source of LP events is located by using different approaches. In the first one, we used a method based on the measurement of the time delays between the early beginnings of LP events for each array receiver. The observed differences of time delays obtained for each pair of receivers are compared to theoretical values calculated from the travel times computed between grid nodes, which are positioned in the structure, and each receiver. In a second approach, we estimate the slowness vector by using MUSIC algorithm applied to 3-components data. From the slowness vector, we deduce the back-azimuth and the incident angle, which give an estimation of LP source depth in the conduit. This work is part of the Domerapi project funded by French Agence Nationale de la Recherche (https

77 FR 44113 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2012-07-27

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Aerospace LP (Type Certificate previously held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150... to the manufacturer. This action was prompted by a report from the Civil Aviation Authority of Israel...

Lr-Lp Stability of the Incompressible Flows with Nonzero Far-Field Velocity

Directory of Open Access Journals (Sweden)

Jaiok Roh

2011-01-01

Full Text Available We consider the stability of stationary solutions w for the exterior Navier-Stokes flows with a nonzero constant velocity u∞ at infinity. For u∞=0 with nonzero stationary solution w, Chen (1993, Kozono and Ogawa (1994, and Borchers and Miyakawa (1995 have studied the temporal stability in Lp spaces for 11 and obtain Lr-Lp stability as Kozono and Ogawa and Borchers and Miyakawa obtained for u∞=0.

75 FR 8921 - Grant of Authority for Subzone Status; Brightpoint North America L.P. (Cell Phone Kitting and...

Science.gov (United States)

2010-02-26

... Status; Brightpoint North America L.P. (Cell Phone Kitting and Distribution) Indianapolis, IN Pursuant to... the cell phone kitting and distribution facilities of Brightpoint North America L.P., located in... cell phones at the facilities of Brightpoint North America L.P., located in Plainfield, Indiana...

ChLpMab-23: Cancer-Specific Human-Mouse Chimeric Anti-Podoplanin Antibody Exhibits Antitumor Activity via Antibody-Dependent Cellular Cytotoxicity.

Science.gov (United States)

Kaneko, Mika K; Nakamura, Takuro; Kunita, Akiko; Fukayama, Masashi; Abe, Shinji; Nishioka, Yasuhiko; Yamada, Shinji; Yanaka, Miyuki; Saidoh, Noriko; Yoshida, Kanae; Fujii, Yuki; Ogasawara, Satoshi; Kato, Yukinari

2017-06-01

Podoplanin is expressed in many cancers, including oral cancers and brain tumors. The interaction between podoplanin and its receptor C-type lectin-like receptor 2 (CLEC-2) has been reported to be involved in cancer metastasis and tumor malignancy. We previously established many monoclonal antibodies (mAbs) against human podoplanin using the cancer-specific mAb (CasMab) technology. LpMab-23 (IgG 1 , kappa), one of the mouse anti-podoplanin mAbs, was shown to be a CasMab. However, we have not shown the usefulness of LpMab-23 for antibody therapy against podoplanin-expressing cancers. In this study, we first determined the minimum epitope of LpMab-23 and revealed that Gly54-Leu64 peptide, especially Gly54, Thr55, Ser56, Glu57, Asp58, Arg59, Tyr60, and Leu64 of podoplanin, is a critical epitope of LpMab-23. We further produced human-mouse chimeric LpMab-23 (chLpMab-23) and investigated whether chLpMab-23 exerts antibody-dependent cellular cytotoxicity (ADCC) and antitumor activity. In flow cytometry, chLpMab-23 showed high sensitivity against a podoplanin-expressing glioblastoma cell line, LN319, and an oral cancer cell line, HSC-2. chLpMab-23 also showed ADCC activity against podoplanin-expressing CHO cells (CHO/podoplanin). In xenograft models with HSC-2 and CHO/podoplanin, chLpMab-23 exerts antitumor activity using human natural killer cells, indicating that chLpMab-23 could be useful for antibody therapy against podoplanin-expressing cancers.

Estimating the Population Impact of Lp(a) Lowering on the Incidence of Myocardial Infarction and Aortic Stenosis

DEFF Research Database (Denmark)

Afshar, Mehdi; Kamstrup, Pia R; Williams, Ken

2016-01-01

OBJECTIVE: High lipoprotein(a) (Lp[a]) is the most common genetic dyslipidemia and is a causal factor for myocardial infarction (MI) and aortic stenosis (AS). We sought to estimate the population impact of Lp(a) lowering that could be achieved in primary prevention using the therapies in developm......OBJECTIVE: High lipoprotein(a) (Lp[a]) is the most common genetic dyslipidemia and is a causal factor for myocardial infarction (MI) and aortic stenosis (AS). We sought to estimate the population impact of Lp(a) lowering that could be achieved in primary prevention using the therapies...... as measures of the population impact. For MI, the event rate was 4.0% versus 2.8% for high versus low Lp(a) (relative risk, 1.46; 95% confidence interval [CI], 1.45-1.46). The attributable risk was 1.26% (95% CI, 1.24-1.27), corresponding to 31.3% (95% CI, 31.0-31.7) of the excess MI risk in those with high...... and 7.8% for AS. CONCLUSIONS: Lp(a) lowering among the top 20% of the population distribution for Lp(a) could prevent 1 in 14 cases of MI and 1 in 7 cases of AS, suggesting a major impact on reducing the burden of cardiovascular disease. Targeting the top 10% could prevent 1 in 20 MI cases and 1 in 12...

78 FR 11639 - Houston Pipe Line Company LP; Notice of Petition for Rate Approval

Science.gov (United States)

2013-02-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-31-000] Houston Pipe Line Company LP; Notice of Petition for Rate Approval Take notice that on February 1, 2013, Houston Pipe Line Company LP (HPL) filed for approval of rates for transportation service pursuant to section...

TRAC-PF1 code assessment using OECD LOFT LP-FP-1 experiment

International Nuclear Information System (INIS)

Barbero, F.J.

1992-04-01

This report assesses thermal-hydraulic aspects of LOFT LP-FP-1 experiment making use of TRAC-PF1/MOD1. LP-FP-1 experiment studies the system thermal-hydraulic and core thermal response for initial and boundary conditions similar to a large-break design basis LOCA leading to fission product release from the fuel cladding gap region. It also assesses the fission product retention effectiveness of the PWR-ECCS in best estimate conditions

THE RUNAWAY WHITE DWARF LP400-22 HAS A COMPANION

International Nuclear Information System (INIS)

Kilic, Mukremin; Brown, Warren R.; Kenyon, S. J.; Allende Prieto, Carlos; Swift, B.; Liebert, J.; Agueeros, M. A.

2009-01-01

We report the detection of a radial velocity companion to the extremely low-mass white dwarf (WD) LP400-22. The radial velocity of the WD shows variations with a semiamplitude of 119 km s -1 and a 0.98776 day period, which implies a companion mass of M ≥ 0.37 M sun . The optical photometry rules out a main-sequence companion. Thus the invisible companion is another WD or a neutron star. Using proper-motion measurements and the radial velocity of the binary system, we find that it has an unusual Galactic orbit. LP400-22 is moving away from the Galactic center with a velocity of 396 ± 43 km s -1 , which is very difficult to explain by supernova runaway ejection mechanisms. Dynamical interactions with a massive black hole like that in the Galactic center can in principle explain its peculiar velocity, if the progenitor was a triple star system comprised of a close binary and a distant tertiary companion. Until better proper motions become available, we consider LP400-22 to be most likely a halo star with a very unusual orbit.

LP-tee pikeneb Tartust Pärnuni / Sirje Pärismaa

Index Scriptorium Estoniae

Pärismaa, Sirje, 1958-

2015-01-01

Norrast pärit tõenduspõhist koostöökultuuri arendava LP-mudeliga (learning environment and pedagogical analysis) on liitumas seitse kooli Pärnust, Viljandist, Puhjast, Tartust ning kolm lasteaeda

Defense Acquisition Reform, 19602009: An Elusive Goal

Science.gov (United States)

2011-10-31

the seven largest economies of the world (United States, China, Japan, Germany, France, United Kingdom, and Italy ).11 Major weapon systems...the Federal Acquisition Regulation.96 95 Ibid., pp. 20, 21. 96 Joseph Ferrara , “DoD’s 5000 Documents: Evolution and Change in Defense Acquisition...Wayne Smith. How Much Is Enough: Shaping the Defense Program, 1961–1969. New York: Harper & Row, 1971. Ferrara , Joseph. “DoD’s 5000 Documents

Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.

Science.gov (United States)

Szymula, Agnieszka; Palermo, Richard D; Bayoumy, Amr; Groves, Ian J; Ba Abdullah, Mohammed; Holder, Beth; White, Robert E

2018-02-01

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vitro. We generated EBNA-LP knockout (LPKO) EBVs containing a STOP codon within each repeat unit of internal repeat 1 (IR1). EBNA-LP-mutant EBVs established lymphoblastoid cell lines (LCLs) from adult B cells at reduced efficiency, but not from umbilical cord B cells, which died approximately two weeks after infection. Adult B cells only established EBNA-LP-null LCLs with a memory (CD27+) phenotype. Quantitative PCR analysis of virus gene expression after infection identified both an altered ratio of the EBNA genes, and a dramatic reduction in transcript levels of both EBNA2-regulated virus genes (LMP1 and LMP2) and the EBNA2-independent EBER genes in the first 2 weeks. By 30 days post infection, LPKO transcription was the same as wild-type EBV. In contrast, EBNA2-regulated cellular genes were induced efficiently by LPKO viruses. Chromatin immunoprecipitation revealed that EBNA2 and the host transcription factors EBF1 and RBPJ were delayed in their recruitment to all viral latency promoters tested, whereas these same factors were recruited efficiently to several host genes, which exhibited increased EBNA2 recruitment. We conclude that EBNA-LP does not simply co-operate with EBNA2 in activating gene transcription, but rather facilitates the recruitment of several transcription factors to the viral genome, to enable transcription of virus latency genes. Additionally, our findings suggest that EBNA-LP is essential for the survival of EBV-infected naïve B cells.

Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome

Science.gov (United States)

Szymula, Agnieszka; Palermo, Richard D.; Bayoumy, Amr; Groves, Ian J.

2018-01-01

The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has been reported to enhance gene activation by the EBV protein EBNA2 in vitro. We generated EBNA-LP knockout (LPKO) EBVs containing a STOP codon within each repeat unit of internal repeat 1 (IR1). EBNA-LP-mutant EBVs established lymphoblastoid cell lines (LCLs) from adult B cells at reduced efficiency, but not from umbilical cord B cells, which died approximately two weeks after infection. Adult B cells only established EBNA-LP-null LCLs with a memory (CD27+) phenotype. Quantitative PCR analysis of virus gene expression after infection identified both an altered ratio of the EBNA genes, and a dramatic reduction in transcript levels of both EBNA2-regulated virus genes (LMP1 and LMP2) and the EBNA2-independent EBER genes in the first 2 weeks. By 30 days post infection, LPKO transcription was the same as wild-type EBV. In contrast, EBNA2-regulated cellular genes were induced efficiently by LPKO viruses. Chromatin immunoprecipitation revealed that EBNA2 and the host transcription factors EBF1 and RBPJ were delayed in their recruitment to all viral latency promoters tested, whereas these same factors were recruited efficiently to several host genes, which exhibited increased EBNA2 recruitment. We conclude that EBNA-LP does not simply co-operate with EBNA2 in activating gene transcription, but rather facilitates the recruitment of several transcription factors to the viral genome, to enable transcription of virus latency genes. Additionally, our findings suggest that EBNA-LP is essential for the survival of EBV-infected naïve B cells. PMID:29462212

Test Report Emission Test Program EPA Information Collection Request for Delayed Coking Units 736 Coker Unit

Science.gov (United States)

ARI Environmental, Inc. (ARI) was retained by Houston Refining LP (HRO) to conduct an emission test program at their refinery located in Houston, Texas. The testing was conducted on on the 736 Delayed Coking Unit (DCU) in response to EPA's ICR.

75 FR 14644 - Gemini Investors IV, L.P., Notice Seeking Exemption Under Section 312 of the Small Business...

Science.gov (United States)

2010-03-26

... SMALL BUSINESS ADMINISTRATION [License No. 01/01-0410] Gemini Investors IV, L.P., Notice Seeking... given that Gemini Investors IV, L.P., 20 William Street, Wellesley, MA 02481, a Federal Licensee under... Regulations (13 CFR 107.730). Gemini Investors IV, L.P. proposes to provide equity and debt financing to...

Lithium in LP944-20

Science.gov (United States)

Pavlenko, Ya. V.; Jones, H. R. A.; Martín, E. L.; Guenther, E.; Kenworthy, M. A.; Zapatero Osorio, M. R.

2007-09-01

We present a new estimate of the lithium abundance in the atmosphere of the brown dwarf LP944-20. Our analysis is based on a self-consistent analysis of low-, intermediate- and high-resolution optical and near-infrared spectra. We obtain logN(Li) = 3.25 +/- 0.25 using fits of our synthetic spectra to the LiI resonance line doublet profiles observed with Very Large Telescope/Ultraviolet-Visual Echelle Spectrograph (VLT/UVES) and Anglo-Australian Telescope/Segmented Pupil/Image Reformatting Array of Lenslets (AAT/SPIRAL). This lithium abundance is over two orders of magnitude larger than previous estimates in the literature. In order to obtain good fits of the resonance lines of KI and RbI and better fits to the TiO molecular absorption around the LiI resonance line, we invoke a semi-empirical model atmosphere with the dusty clouds located above the photosphere. The lithium abundance, however, is not changed by the effects of the dusty clouds. We discuss the implications of our estimate of the lithium abundance in LP944-20 for the understanding of the properties of this benchmark brown dwarf. Based on observations obtained on the European Southern Observatory at Cerro Paranal, Chile, in programs 68.C-0063(A) and 072.C-0110(B), the Anglo-Australian Telescope at Siding Springs Observatory during commissioning observations for SPIRAL (Segmented Pupil/Image Reformatting Array of Lenslets) instrument and the Keck Observatory in Mauna Kea, Hawaii. E-mail: yp@mao.kiev.ua

76 FR 41041 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Interaction of Systems...

Science.gov (United States)

2011-07-13

... Conditions No. 25-439-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Interaction... special conditions are issued for the Gulfstream Aerospace LP (GALP) Model G250 airplane. This airplane...

The lysine-peptoid hybrid LP5 maintain activity under physiological conditions and affects virulence gene expression in Staphylococcus aureus

DEFF Research Database (Denmark)

Gottschalk, Sanne; Ingmer, Hanne; Thomsen, Line E.

2016-01-01

The antimicrobial peptide, LP5, is a lysine-peptoid hybrid, with antimicrobial activity against clinically relevant bacteria. Here, we investigated how various environmental conditions affect the antimicrobial activity of LP5 against Staphylococcus aureus (S. aureus). We found that LP5 maintained...

Statistical Review of Global LP Gas 2002

International Nuclear Information System (INIS)

2002-01-01

This review provides essential production and consumption data from 1991 through 2001. A detailed breakdown of supply and sector demand is given for the year 2001 and historic data on international trade, shipping and pricing is also shown. Statistics pertaining to auto-gas are also included in this edition of Statistical Review of Global LP Gas 2001. (author)

Statistical review of global LP gas 2001

International Nuclear Information System (INIS)

2001-01-01

This review provides essential production and consumption data from 1990 through 2000. A more detailed breakdown of supply and sector demand is given for the year 2000 and historic data on international trade, shipping and pricing is also shown. Statistics pertaining to auto-gas are also included in this edition of Statistical Review of Global LP Gas 2001. (author)

Novel Monoclonal Antibody LpMab-17 Developed by CasMab Technology Distinguishes Human Podoplanin from Monkey Podoplanin.

Science.gov (United States)

Kato, Yukinari; Ogasawara, Satoshi; Oki, Hiroharu; Honma, Ryusuke; Takagi, Michiaki; Fujii, Yuki; Nakamura, Takuro; Saidoh, Noriko; Kanno, Hazuki; Umetsu, Mitsuo; Kamata, Satoshi; Kubo, Hiroshi; Yamada, Mitsuhiro; Sawa, Yoshihiko; Morita, Kei-Ichi; Harada, Hiroyuki; Suzuki, Hiroyoshi; Kaneko, Mika Kato

2016-04-01

Podoplanin (PDPN) is a type-I transmembrane sialoglycoprotein, which possesses a platelet aggregation-stimulating (PLAG) domain in its N-terminus. Among the three PLAG domains, O-glycan on Thr52 of PLAG3 is critical for the binding with C-type lectin-like receptor-2 (CLEC-2) and is essential for platelet-aggregating activity of PDPN. Although many anti-PDPN monoclonal antibodies (mAbs) have been established, almost all mAbs bind to PLAG domains. We recently established CasMab technology to produce mAbs against membranous proteins. Using CasMab technology, we produced a novel anti-PDPN mAb, LpMab-17, which binds to non-PLAG domains. LpMab-17 clearly detected endogenous PDPN of cancer cells and normal cells in Western-blot, flow cytometry, and immunohistochemistry. LpMab-17 recognized glycan-deficient PDPN in flow cytometry, indicating that the interaction between LpMab-17 and PDPN is independent of its glycosylation. The minimum epitope of LpMab-17 was identified as Gly77-Asp82 of PDPN using enzyme-linked immunosorbent assay. Of interest, LpMab-17 did not bind to monkey PDPN, whereas the homology is 94% between human PDPN and monkey PDPN, indicating that the epitope of LpMab-17 is unique compared with the other anti-PDPN mAbs. The combination of different epitope-possessing mAbs could be advantageous for the PDPN-targeting diagnosis or therapy.

75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

Science.gov (United States)

2010-08-20

... Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Project No.: 7320-040. c. Dated Filed: June 29, 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e...: John Mudre at (202) 502-8902; or e-mail at [email protected] . j. Erie Boulevard Hydropower, L.P...

Poly-(R)-3-hydroxybutyrates (PHB) are Atherogenic Components of Lipoprotein Lp(a).

Science.gov (United States)

Reusch, Rosetta N

2015-12-01

The hypothesis is that poly-(R)-3-hydroxybutyrates (PHB), linear polymers of the ketone body, R-3-hydroxybutyrate (R-3HB), are atherogenic components of lipoprotein Lp(a). PHB are universal constituents of biological cells and are thus components of all foods. Medium chain-length PHB (PHB (PHB are highly insoluble in water, but soluble in lipids in which they exhibit a high intrinsic viscosity. They have a higher density than other cellular lipids and they are very adhesive, i.e. they engage in multiple noncovalent interactions with other molecules and salts via hydrogen, hydrophobic and coordinate bonds, thus producing insoluble deposits. Following digestive processes, PHB enter the circulation in chylomicrons and very low density lipoproteins (VLDL). The majority of the PHB (>70%) are absorbed by albumin, which transports them to the liver for disposal. When the amount of PHB in the diet exceed the capacity of albumin to safely remove them from the circulation, the excess PHB remain in the lipid core of LDL particles that become constituents of lipoprotein Lp(a), and contribute to the formation of arterial deposits. In summary, the presence of PHB – water-insoluble, dense, viscous, adhesive polymers – in the lipid cores of the LDL moieties of Lp(a) particles supports the hypothesis that PHB are atherogenic components of Lp(a).

Univariate Lp and ɭ p Averaging, 0 < p < 1, in Polynomial Time by Utilization of Statistical Structure

Directory of Open Access Journals (Sweden)

John E. Lavery

2012-10-01

Full Text Available We present evidence that one can calculate generically combinatorially expensive Lp and lp averages, 0 < p < 1, in polynomial time by restricting the data to come from a wide class of statistical distributions. Our approach differs from the approaches in the previous literature, which are based on a priori sparsity requirements or on accepting a local minimum as a replacement for a global minimum. The functionals by which Lp averages are calculated are not convex but are radially monotonic and the functionals by which lp averages are calculated are nearly so, which are the keys to solvability in polynomial time. Analytical results for symmetric, radially monotonic univariate distributions are presented. An algorithm for univariate lp averaging is presented. Computational results for a Gaussian distribution, a class of symmetric heavy-tailed distributions and a class of asymmetric heavy-tailed distributions are presented. Many phenomena in human-based areas are increasingly known to be represented by data that have large numbers of outliers and belong to very heavy-tailed distributions. When tails of distributions are so heavy that even medians (L1 and l1 averages do not exist, one needs to consider using lp minimization principles with 0 < p < 1.

Equalizer Complexity for 6-LP Mode 112 Gbit/s m-ary DP-QAM Space Division Multiplexed Transmission in Strongly Coupled Few-Mode-Fibers

DEFF Research Database (Denmark)

Asif, Rameez; Ye, Feihong; Morioka, Toshio

2015-01-01

12×12 multiple-input multiple-output (MIMO) adaptive digital signal processing (DSP). Time domain equalization (TDE) is realized to implement the linear adaptive MIMO module that is implemented in blind mode using conventional constant-modulusalgorithm (CMA) for finite impulse response (FIR) adaptive......We have quantified equalizer complexity for transmitting dual-polarized 6-LP modes (LP01, LP11a, LP11b, LP21a, LP21b and LP02) of 112 Gbit/s m-ary QAM (m=4, 16, 32, 64, 256) single carrier signals over 20 km step-index few-mode fiber. The transmitted signals are strongly coupled and recovered using...

75 FR 35017 - Brookfield Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2010-06-21

... Energy Marketing LP; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of Brookfield Energy Marketing LP's application for market-based rate authority, with an... protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov . To...

Validation of ozone profile retrievals derived from the OMPS LP version 2.5 algorithm against correlative satellite measurements

Science.gov (United States)

Kramarova, Natalya A.; Bhartia, Pawan K.; Jaross, Glen; Moy, Leslie; Xu, Philippe; Chen, Zhong; DeLand, Matthew; Froidevaux, Lucien; Livesey, Nathaniel; Degenstein, Douglas; Bourassa, Adam; Walker, Kaley A.; Sheese, Patrick

2018-05-01

The Limb Profiler (LP) is a part of the Ozone Mapping and Profiler Suite launched on board of the Suomi NPP satellite in October 2011. The LP measures solar radiation scattered from the atmospheric limb in ultraviolet and visible spectral ranges between the surface and 80 km. These measurements of scattered solar radiances allow for the retrieval of ozone profiles from cloud tops up to 55 km. The LP started operational observations in April 2012. In this study we evaluate more than 5.5 years of ozone profile measurements from the OMPS LP processed with the new NASA GSFC version 2.5 retrieval algorithm. We provide a brief description of the key changes that had been implemented in this new algorithm, including a pointing correction, new cloud height detection, explicit aerosol correction and a reduction of the number of wavelengths used in the retrievals. The OMPS LP ozone retrievals have been compared with independent satellite profile measurements obtained from the Aura Microwave Limb Sounder (MLS), Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) and Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS). We document observed biases and seasonal differences and evaluate the stability of the version 2.5 ozone record over 5.5 years. Our analysis indicates that the mean differences between LP and correlative measurements are well within required ±10 % between 18 and 42 km. In the upper stratosphere and lower mesosphere (> 43 km) LP tends to have a negative bias. We find larger biases in the lower stratosphere and upper troposphere, but LP ozone retrievals have significantly improved in version 2.5 compared to version 2 due to the implemented aerosol correction. In the northern high latitudes we observe larger biases between 20 and 32 km due to the remaining thermal sensitivity issue. Our analysis shows that LP ozone retrievals agree well with the correlative satellite observations in characterizing vertical, spatial and temporal

Increased intra-abdominal fat may lower HDL levels by increasing the fractional catabolic rate of Lp A-I in postmenopausal women.

Science.gov (United States)

Vajo, Zoltan; Terry, James G; Brinton, Eliot A

2002-02-01

High-density lipoprotein (HDL) particles without apolipoprotein A-II (Lp A-I) may be more anti-atherogenic than HDL with apo A-II (Lp A-I/AII) and Lp A-I is reported selectively to be reduced in cases of intra-abdominal obesity. We explored the mechanisms of this reduction by studying the turnover of Lp A-I and Lp A-I/A-II in postmenopausal women well characterized for total body, regional and sub-regional adiposity by body mass index (BMI), truncal girth ratio, and abdominal magnetic resonance imaging (MRI), respectively. We tested for possible cause-effect relationships by measuring inter-correlations among these variables. Intra-abdominal fat area correlated strongly and positively with the fractional catabolic rate (FCR) of Lp A-I (r=0.98, P=0.003). Intra-abdominal fat only showed a non-significant trend toward correlation with the FCR of Lp A-I/A-II (r=0.84, P=0.07), and had no correlation with the production or transport rate (TR) of either Lp A-I or Lp A-I/A-II (r=0.48 and 0.02, respectively, P>0.1). Subjects were studied both with and without estrogen replacement, allowing exploration of a possible interaction of adiposity with estrogen effects on HDL turnover. Response of HDL turnover to estrogen did not correlate with adiposity, except for a parameter of waist to hip ratio (WHR), which predicted the increase in LP A-I TR with estrogen (r=0.84, P=0.04). We conclude that intra-abdominal fat may lower HDL levels by increasing the FCR of Lp A-I, suggesting a mechanism by which central adiposity may be proatherogenic.

Modulation of gut barrier function in patients with obstructive jaundice using probiotic LP299v.

Science.gov (United States)

Jones, Claire; Badger, Stephen A; Regan, Mark; Clements, Barry W; Diamond, Tom; Parks, Rowan W; Taylor, Mark A

2013-12-01

This study aimed to determine the effect of LP229v on intestinal permeability and tumour necrosis factor (TNF) p55 receptor concentrations in patients with obstructive jaundice undergoing biliary drainage. Patients undergoing biliary drainage were recruited and randomized into three groups to receive Lactobacillus plantarum 299v (LP299v), inactivated LP299v (placebo) or water. These were administered daily at noon until 7 days after biliary drainage. Intestinal permeability was measured using the lactulose/mannitol (L/M) dual sugar absorption test on admission, the day before biliary drainage and on days 1 and 7 after biliary drainage. Blood and urine were collected to determine the L/M ratio and the TNF p55 receptor levels at each time point. A total of 25 patients were recruited; 12 had choledocholithiasis and nine had a periampullary tumour. Open surgical biliary drainage was performed in nine patients, endoscopic retrograde cholangiopancreatography in 12 and percutaneous transhepatic cholangiography in two. Five patients received LP299v, five received placebo and seven, water. The median L/M ratio was 0.035 (0.018-0.065) at baseline. No difference existed between the groups on admission, before drainage and on day 7 after drainage (P=0.59, 0.175 and 0.61, respectively). The L/M ratio was lower in the LP299v group on day 1 after drainage [0.01 (0.01) vs. 0.18 (0.03-0.3) and 0.11 (0.07-0.14); P=0.37]. Although the TNF p55 receptor levels were lower on day 1 after drainage in the LP299v group (15.3 vs. 30.9 vs. 82.7 ng/ml; P=0.43), the concentration at the four time points was similar (P=0.24, 0.96, 0.43 and 0.68). Pretreatment with probiotic LP299v improves intestinal permeability after biliary drainage and attenuates the inflammatory response. However, a larger multicentre trial is required to determine the effect on clinical outcome.

Who's who in the LP-Gas industry

International Nuclear Information System (INIS)

Anon.

1997-01-01

All pertinent information about the most important North American companies in the LP-Gas industry are listed alphabetically in an easy-to-use directory. A total of 395 listings are included. Besides company names and addresses, other information such as key personnel and products produced and marketed to affiliated companies, and a list of other services offered by each company are also provided

Dødshjælp, drabsforbud og deontologi

DEFF Research Database (Denmark)

Dige, Morten

2008-01-01

Et velkendt argument imod aktiv dødshjælp har det deontologiske forbud mod drab eller pligten til ikke at slå ihjel som en central præmis. Sådanne deontologiske argumenter spiller en fremtrædende rolle i nylige publikationer fra Det Etiske Råd. For at gælde ukvalificeret, må disse argumenter imid...

76 FR 12103 - Erie Boulevard Hydropower, L.P; Notice of Settlement Agreement and Soliciting Comments

Science.gov (United States)

2011-03-04

... Hydropower, L.P; Notice of Settlement Agreement and Soliciting Comments Take notice that the following... Boulevard Hydropower, L.P. e. Location: The existing multi-development project is located on the Oswegatchie... 791 (a)-825(r) h. Applicant Contact: Daniel Daoust, Erie Boulevard Hydropower, 33 West 1st Street...

Anti-soluble liver antigen/liver-pancreas (SLA/LP) antibodies in pediatric patients with autoimmune hepatitis.

Science.gov (United States)

Vitozzi, Susana; Djilali-Saiah, Idriss; Lapierre, Pascal; Alvarez, Fernando

2002-12-01

Antibodies against soluble liver antigen/liver-pancreas (SLA/LP) have been associated with severe autoimmune hepatitis (AIH) and poor outcome, but most of these reports have focused on adult patients. The aim of this study was to assess the prevalence and clinical significance of anti-SLA/LP antibodies in a pediatric population with AIH. We developed a quantitative enzyme-linked immunoassay (ELISA), a Western blot (WB) and an immunoprecipitation assay (IPA) based on recombinant cDNA from activated Jurkat cells. The specificity of these tests was validated by testing 200 serum samples from healthy subjects, and from patients with liver and non-liver diseases. Anti-SLA/LP antibodies were found in patients with type 1 and type 2 AIH. The prevalence of these antibodies in patients with type 1 AIH was: 42% when tested by ELISA, 15% by WB and 50% by IPA. In patients with type 2 AIH, the prevalence rates were 42% by ELISA, 18% by WB and 44% by IPA. The mean titer values for anti-SLA/LP antibodies was significantly higher in type 2 AIH (1:1,300 +/- 339) than in type 1 AIH (1:600 +/- 71; p LKM1) and anti-liver cytosol type 1 (LC1) antibodies in sera. The presence of anti-SLA/LP showed a significant female preponderance in type 1 and 2 AIH patients (p = 0.0003 and p = 0.003, respectively), and was significantly correlated with a lower age at diagnosis (p = 0.05) in type 1 AIH patients. In conclusion, anti-SLA/LP antibodies in pediatric patients are associated with both type 1 and 2 AIH.

Increase in Multicast OFDM Data Rate in PLC Network using Adaptive LP-OFDM

OpenAIRE

Maiga , Ali; Baudais , Jean-Yves; Hélard , Jean-François

2009-01-01

ISBN: 978-1-4244-3523-4; International audience; Linear precoding (LP) technique applied to OFDM systems has already proved its ability to significantly increase the system throughput in a powerline communication (PLC) context. In this paper, we propose resource allocation algorithms based on the LP technique to increase the multicast OFDM systems bit rate. The conventional multicast capacity is limited by the user which experiences the worst channel conditions. To increase the multicast bit ...

Increased risk of coronary artery calcification progression in subjects with high baseline Lp(a) levels: The Kangbuk Samsung Health Study.

Science.gov (United States)

Cho, Jung Hwan; Lee, Da Young; Lee, Eun Seo; Kim, Jihyun; Park, Se Eun; Park, Cheol-Young; Lee, Won-Young; Oh, Ki-Won; Park, Sung-Woo; Rhee, Eun-Jung

2016-11-01

Results from previous studies support the association of lipoprotein(a) [Lp(a)] levels and coronary artery disease risk. In this study, we analyzed the association between baseline Lp(a) levels and future progression of coronary artery calcification (CAC) in apparently healthy Korean adults. A total of 2611 participants (mean age: 41years, 92% mend) who underwent a routine health check-up in 2010 and 2014 were enrolled. Coronary artery calcium score (CACS) were measured by multi-detector computed tomography. Baseline Lp(a) was measured by high-sensitivity immunoturbidimetric assay. Progression of CAC was defined as a change in CACS >0 over four years. Bivariate correlation analyses with baseline Lp(a) and other metabolic parameters revealed age, total cholesterol, HDL-C, LDL-C and CACS to have a significant positive correlation, while body weight, fasting glucose level, blood pressure and triglyceride level were negatively correlated with baseline Lp(a) level. After four years of follow-up, 635 subjects (24.3%) had CAC progression. The participants who had CAC progression were older, composed of more men, more obese, and had higher fasting glucose levels and worse baseline lipid profiles compared to those who did not have CAC progression. The mean serum Lp(a) level was significantly higher in subjects who had CAC progression compared to those who did not (32.5 vs. 28.9mg/dL, p<0.01). When the risk for CAC progression according to baseline Lp(a) was calculated, those with Lp(a) level≥50mg/dL had an odds ratio of 1.333 (95% CI 1.027-1.730) for CAC progression compared to those with Lp(a)<50mg/dL after adjusting for confounding factors. In this study, the subjects who had higher Lp(a) were at significantly higher risk for CAC progression after four years of follow-up, suggesting the role of high Lp(a) in CAC progression. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

77 FR 71585 - Brookfield Energy Marketing LP v. ISO New England Inc.; Notice of Complaint

Science.gov (United States)

2012-12-03

... Energy Marketing LP v. ISO New England Inc.; Notice of Complaint Take notice that on November 21, 2012...), Brookfield Energy Marketing LP (Complainant) filed a formal complaint against ISO New England Inc... notification when a document is added to a subscribed docket(s). For assistance with any FERC Online service...

76 FR 45247 - Tesoro Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint

Science.gov (United States)

2011-07-28

... Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint Take notice that on July 20, 2011... Marketing Company (Complainant) filed a formal complaint against SFPP L.P. (SFPP or Respondent) alleging... with any FERC Online service, please e-mail [email protected] , or call (866) 208-3676 (toll...

Sunoco Pipeline, L.P. Clean Water Act Settlement - 2017

Science.gov (United States)

EPA, and the U.S. Department of Justice announced that Sunoco Pipeline, L.P. (Sunoco) has agreed to pay a civil penalty for alleged violation of the Clean Water Act stemming from a 2012 gasoline discharge near Wellington, Ohio.

How to optimize joint theater ballistic missile defense

OpenAIRE

Diehl, Douglas D.

2004-01-01

Approved for public release, distribution is unlimited Many potential adversaries seek, or already have theater ballistic missiles capable of threatening targets of interest to the United States. The U.S. Missile Defense Agency and armed forces are developing and fielding missile interceptors carried by many different platforms, including ships, aircraft, and ground units. Given some exigent threat, the U.S. must decide where to position defensive platforms and how they should engage poten...

Modulation of phosducin-like protein 3 (PhLP3 levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner.

Directory of Open Access Journals (Sweden)

Nandini V L Hayes

Full Text Available Phosducin-like protein 3 (PhLP3 forms a ternary complex with the ATP-dependent molecular chaperone CCT and its folding client tubulin. In vitro studies suggest PhLP3 plays an inhibitory role in β-tubulin folding while conversely in vivo genetic studies suggest PhLP3 is required for the correct folding of β-tubulin. We have a particular interest in the cytoskeleton, its chaperones and their role in determining cellular phenotypes associated with high level recombinant protein expression from mammalian cell expression systems.As studies into PhLP3 function have been largely carried out in non mammalian systems, we examined the effect of human PhLP3 over-expression and siRNA silencing using a single murine siRNA on both tubulin and actin systems in mammalian Chinese hamster ovary (CHO cell lines. We show that over-expression of PhLP3 promotes an imbalance of α and β tubulin subunits, microtubule disassembly and cell death. In contrast, β-actin levels are not obviously perturbed. On-the-other-hand, RNA silencing of PhLP3 increases RhoA-dependent actin filament formation and focal adhesion formation and promotes a dramatic elongated fibroblast-like change in morphology. This was accompanied by an increase in phosphorylated MAPK which has been associated with promoting focal adhesion assembly and maturation. Transient overexpression of PhLP3 in knockdown experiments rescues cells from the morphological change observed during PhLP3 silencing but mitosis is perturbed, probably reflecting a tipping back of the balance of PhLP3 levels towards the overexpression state.Our results support the hypothesis that PhLP3 is important for the maintenance of β-tubulin levels in mammalian cells but also that its modulation can promote actin-based cytoskeletal remodelling by a mechanism linked with MAPK phosphorylation and RhoA-dependent changes. PhLP3 levels in mammalian cells are thus finely poised and represents a novel target for engineering industrially

76 FR 45246 - Tesoro Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint

Science.gov (United States)

2011-07-28

... and Marketing Company v. SFPP, L.P.; Notice of Complaint Take notice that on July 20, 2011, pursuant...), Tesoro Refining and Marketing Company (Tesoro) filed a formal complaint against SFPP, L.P. (SFPP). Tesoro... notification when a document is added to a subscribed docket(s). For assistance with any FERC Online service...

77 FR 28375 - Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval

Science.gov (United States)

2012-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-25-000] Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval Take notice that on May 1, 2012, Eagle Rock Desoto Pipeline, L.P. (Desoto) filed a Rate Election pursuant to 284.123(b)(1) of the Commissions...

State of the Art in LP-WAN Solutions for Industrial IoT Services

OpenAIRE

Sanchez-Iborra, Ramon; Cano, Maria-Dolores

2016-01-01

The emergence of low-cost connected devices is enabling a new wave of sensorization services. These services can be highly leveraged in industrial applications. However, the technologies employed so far for managing this kind of system do not fully cover the strict requirements of industrial networks, especially those regarding energy efficiency. In this article a novel paradigm, called Low-Power Wide Area Networking (LP-WAN), is explored. By means of a cellular-type architecture, LP-WAN–base...

76 FR 66710 - Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing, Soliciting Comments...

Science.gov (United States)

2011-10-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 5984-063] Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing, Soliciting Comments, Motions To Intervene, and....: 5984-063. c. Date Filed: May 10, 2011. d. Applicant: Erie Boulevard Hydropower, L.P. (dba Brookfield...

Validation of ozone profile retrievals derived from the OMPS LP version 2.5 algorithm against correlative satellite measurements

Directory of Open Access Journals (Sweden)

N. A. Kramarova

2018-05-01

Full Text Available The Limb Profiler (LP is a part of the Ozone Mapping and Profiler Suite launched on board of the Suomi NPP satellite in October 2011. The LP measures solar radiation scattered from the atmospheric limb in ultraviolet and visible spectral ranges between the surface and 80 km. These measurements of scattered solar radiances allow for the retrieval of ozone profiles from cloud tops up to 55 km. The LP started operational observations in April 2012. In this study we evaluate more than 5.5 years of ozone profile measurements from the OMPS LP processed with the new NASA GSFC version 2.5 retrieval algorithm. We provide a brief description of the key changes that had been implemented in this new algorithm, including a pointing correction, new cloud height detection, explicit aerosol correction and a reduction of the number of wavelengths used in the retrievals. The OMPS LP ozone retrievals have been compared with independent satellite profile measurements obtained from the Aura Microwave Limb Sounder (MLS, Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS and Odin Optical Spectrograph and InfraRed Imaging System (OSIRIS. We document observed biases and seasonal differences and evaluate the stability of the version 2.5 ozone record over 5.5 years. Our analysis indicates that the mean differences between LP and correlative measurements are well within required ±10 % between 18 and 42 km. In the upper stratosphere and lower mesosphere (> 43 km LP tends to have a negative bias. We find larger biases in the lower stratosphere and upper troposphere, but LP ozone retrievals have significantly improved in version 2.5 compared to version 2 due to the implemented aerosol correction. In the northern high latitudes we observe larger biases between 20 and 32 km due to the remaining thermal sensitivity issue. Our analysis shows that LP ozone retrievals agree well with the correlative satellite observations in characterizing

Serum Lp-PLA2: as a novel viewpoint in periodontal treatment of hyperlipidaemics.

Science.gov (United States)

Fentoğlu, Özlem; Kirzioğlu, Fatma Yeşim; Tözüm Bulut, Memduha; Kurgan, Şivge; Koçak, Havva; Sütcü, Recep; Kale Köroğlu, Banu; Günhan, Meral

2015-01-01

To evaluate the effects of periodontal treatment on serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) levels in hyperlipidaemic patients with periodontitis. The study included 52 hyperlipidaemics and 28 systemically healthy controls (C) with periodontitis. Of the 52 hyperlipidaemics, 29 received a suggested diet (HD), and 23 of them were prescribed statin (HS). Clinical periodontal parameters, serum lipids, Lp-PLA2, and CRP levels were assessed at the baseline and 2 months after the completion of the nonsurgical periodontal treatment (2MPT). Serum parameters were also evaluated 1 week following the periodontal treatment (1WPT). At the baseline, patients in the HS group had a higher percentage of bleeding on probing than those in the C and HD groups. Hyperlipidaemics had higher serum triglyceride levels than the control group at 2MPT compared to the baseline. At 2MPT, the levels of Lp-PLA2 in the HS group were significantly higher compared to the baseline and 1WPT. There were no statistically significant differences in CRP levels between study periods for all groups. The periodontal treatment may affect the inflammatory control of hyperlipidaemic patients with periodontitis via increased Lp-PLA2 levels and severity of the impaired lipid metabolism. These findings may be important regarding the therapeutic strategies for hyperlipidaemics with periodontitis.

76 FR 72245 - Implementation of Defense Trade Cooperation Treaties

Science.gov (United States)

2011-11-22

... equipment sold under a contract in the amount of $25,000,000 or more (currently required for amounts of $14... equipment sold under a contract in the amount in the amount of $25,000,000 or more, or for defense articles... the Defense Trade Cooperation Treaty between the United States and Australia and the Defense Trade...

76 FR 81360 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

Science.gov (United States)

2011-12-28

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. FAA-2011-1172: Special Conditions No. 25-453-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G280... Aerospace LP (GALP) Model G280 airplane. This airplane will have a novel or unusual design feature...

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study.

Science.gov (United States)

Siddiqui, Moneeza K; Kennedy, Gwen; Carr, Fiona; Doney, Alexander S F; Pearson, Ewan R; Morris, Andrew D; Johnson, Toby; McLaughlin, Megan M; Williams, Rachel E; Palmer, Colin N A

2018-06-01

The aim of the study was to examine the association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) activity levels and incident diabetic retinopathy and change in retinopathy grade. This was a cohort study of diabetic participants with serum collected at baseline and routinely collected diabetic retinal screening data. Participants with type 2 diabetes from the GoDARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) cohort were used. This cohort is composed of individuals of white Scottish ancestry from the Tayside region of Scotland. Survival analysis accounting for informative censoring by modelling death as a competing risk was performed for the development of incident diabetic retinopathy from a disease-free state in a 3 year follow-up period (n = 1364) by stratified Lp-PLA 2 activity levels (in quartiles). The same analysis was performed for transitions to more severe grades. The hazard of developing incident diabetic retinopathy was 2.08 times higher (95% CI 1.64, 2.63) for the highest quartile of Lp-PLA 2 activity compared with the lowest. Higher Lp-PLA 2 activity levels were associated with a significantly increased risk for transitions to all grades. The hazards of developing observable (or more severe) and referable (or more severe) retinopathy were 2.82 (95% CI 1.71, 4.65) and 1.87 (95% CI 1.26, 2.77) times higher for the highest quartile of Lp-PLA 2 activity compared with the lowest, respectively. Higher Lp-PLA 2 levels are associated with increased risk of death and the development of incident diabetic retinopathy, as well as transitions to more severe grades of diabetic retinopathy. These associations are independent of calculated LDL-cholesterol and other traditional risk factors. Further, this biomarker study shows that the association is temporally sensitive to the proximity of the event to measurement of Lp-PLA 2.

76 FR 25229 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane, Dynamic Test Requirements...

Science.gov (United States)

2011-05-04

... Memorandum ``Side-Facing Seats on Transport Category Airplanes'' and draft Issue Paper ``Dynamic Test...; Special Conditions No. 25-425-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G250 Airplane... are issued for the Gulfstream Aerospace LP (GALP) model G250 airplane. This airplane will have a novel...

76 FR 66660 - Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane, Operation Without Normal...

Science.gov (United States)

2011-10-27

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 25 [Docket No. FAA-2011-1172: Notice No. 25-11-17-SC] Special Conditions: Gulfstream Aerospace LP (GALP) Model G280 Airplane... Aerospace LP (GALP) Model G280 airplane. This airplane will have a novel or unusual design feature...

Antitumor activity of chLpMab-2, a human-mouse chimeric cancer-specific antihuman podoplanin antibody, via antibody-dependent cellular cytotoxicity.

Science.gov (United States)

Kaneko, Mika K; Yamada, Shinji; Nakamura, Takuro; Abe, Shinji; Nishioka, Yasuhiko; Kunita, Akiko; Fukayama, Masashi; Fujii, Yuki; Ogasawara, Satoshi; Kato, Yukinari

2017-04-01

Human podoplanin (hPDPN), a platelet aggregation-inducing transmembrane glycoprotein, is expressed in different types of tumors, and it binds to C-type lectin-like receptor 2 (CLEC-2). The overexpression of hPDPN is involved in invasion and metastasis. Anti-hPDPN monoclonal antibodies (mAbs) such as NZ-1 have shown antitumor and antimetastatic activities by binding to the platelet aggregation-stimulating (PLAG) domain of hPDPN. Recently, we developed a novel mouse anti-hPDPN mAb, LpMab-2, using the cancer-specific mAb (CasMab) technology. In this study we developed chLpMab-2, a human-mouse chimeric anti-hPDPN antibody, derived from LpMab-2. chLpMab-2 was produced using fucosyltransferase 8-knockout (KO) Chinese hamster ovary (CHO)-S cell lines. By flow cytometry, chLpMab-2 reacted with hPDPN-expressing cancer cell lines including glioblastomas, mesotheliomas, and lung cancers. However, it showed low reaction with normal cell lines such as lymphatic endothelial and renal epithelial cells. Moreover, chLpMab-2 exhibited high antibody-dependent cellular cytotoxicity (ADCC) against PDPN-expressing cells, despite its low complement-dependent cytotoxicity. Furthermore, treatment with chLpMab-2 abolished tumor growth in xenograft models of CHO/hPDPN, indicating that chLpMab-2 suppressed tumor development via ADCC. In conclusion, chLpMab-2 could be useful as a novel antibody-based therapy against hPDPN-expressing tumors. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Genome-wide association study of Lp-PLA(2 activity and mass in the Framingham Heart Study.

Directory of Open Access Journals (Sweden)

Sunil Suchindran

2010-04-01

Full Text Available Lipoprotein-associated phospholipase A(2 (Lp-PLA(2 is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2 activity and mass in 6,668 Caucasian subjects from the population-based Framingham Heart Study. Clinical data and genotypes from the Affymetrix 550K SNP array were obtained from the open-access Framingham SHARe project. Each polymorphism that passed quality control was tested for associations with Lp-PLA(2 activity and mass using linear mixed models implemented in the R statistical package, accounting for familial correlations, and controlling for age, sex, smoking, lipid-lowering-medication use, and cohort. For Lp-PLA(2 activity, polymorphisms at four independent loci reached genome-wide significance, including the APOE/APOC1 region on chromosome 19 (p = 6 x 10(-24; CELSR2/PSRC1 on chromosome 1 (p = 3 x 10(-15; SCARB1 on chromosome 12 (p = 1x10(-8 and ZNF259/BUD13 in the APOA5/APOA1 gene region on chromosome 11 (p = 4 x 10(-8. All of these remained significant after accounting for associations with LDL cholesterol, HDL cholesterol, or triglycerides. For Lp-PLA(2 mass, 12 SNPs achieved genome-wide significance, all clustering in a region on chromosome 6p12.3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2 activity and mass.

Japan and Ballistic Missile Defense

National Research Council Canada - National Science Library

Swaine, Michael

2001-01-01

Spurred by a perceived growing ballistic missile threat from within the Asia-Pacific region and requests from the United States to support research and development on components of a missile defense...

Learning to perceive and recognize a second language: the L2LP model revised.

Science.gov (United States)

van Leussen, Jan-Willem; Escudero, Paola

2015-01-01

We present a test of a revised version of the Second Language Linguistic Perception (L2LP) model, a computational model of the acquisition of second language (L2) speech perception and recognition. The model draws on phonetic, phonological, and psycholinguistic constructs to explain a number of L2 learning scenarios. However, a recent computational implementation failed to validate a theoretical proposal for a learning scenario where the L2 has less phonemic categories than the native language (L1) along a given acoustic continuum. According to the L2LP, learners faced with this learning scenario must not only shift their old L1 phoneme boundaries but also reduce the number of categories employed in perception. Our proposed revision to L2LP successfully accounts for this updating in the number of perceptual categories as a process driven by the meaning of lexical items, rather than by the learners' awareness of the number and type of phonemes that are relevant in their new language, as the previous version of L2LP assumed. Results of our simulations show that meaning-driven learning correctly predicts the developmental path of L2 phoneme perception seen in empirical studies. Additionally, and to contribute to a long-standing debate in psycholinguistics, we test two versions of the model, with the stages of phonemic perception and lexical recognition being either sequential or interactive. Both versions succeed in learning to recognize minimal pairs in the new L2, but make diverging predictions on learners' resulting phonological representations. In sum, the proposed revision to the L2LP model contributes to our understanding of L2 acquisition, with implications for speech processing in general.

77 FR 77122 - Pyxis Capital, L.P., et al.;

Science.gov (United States)

2012-12-31

... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30316; 812-13489-01] Pyxis Capital, L.P., et al.; Notice of Application December 21, 2012. AGENCY: Securities and Exchange Commission (the ``Commission''). ACTION: Notice of an application for an order under section 6(c) of the...

Continuous and Lp estimates for the complex Monge-Ampère equation on bounded domains in ℂn

Directory of Open Access Journals (Sweden)

Patrick W. Darko

2002-01-01

Full Text Available Continuous solutions with continuous data and Lp solutions with Lp data are obtained for the complex Monge-Ampère equation on bounded domains, without requiring any smoothness of the domains.

78 FR 28273 - Alpine Investors IV SBIC, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

Science.gov (United States)

2013-05-14

... SMALL BUSINESS ADMINISTRATION [License No. 09/09-0461] Alpine Investors IV SBIC, LP; Notice... hereby given that Alpine Investors IV SBIC, LP, 3 Embarcadero Center, Suite 2330, San Francisco, CA, a...'') Rules and [[Page 28274

78 FR 68044 - Erie Boulevard Hydropower, L.P.; Notice of Scoping Meetings and Environmental Site Review and...

Science.gov (United States)

2013-11-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7320-042] Erie Boulevard Hydropower, L.P.; Notice of Scoping Meetings and Environmental Site Review and Soliciting Scoping Comments.... Date filed: July 1, 2013. d. Applicant: Erie Boulevard Hydropower, L.P. e. Name of Project: Chasm...

The importance of age and statin therapy in the interpretation of Lp-PLA(2) in ACS patients, and relation to CRP.

Science.gov (United States)

Franeková, J; Kettner, J; Kubíček, Z; Jabor, A

2015-01-01

C-reactive protein (CRP) is a marker of arterial inflammation while lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is related to plaque instability. The aim of this study was to evaluate the correlation between the risk of unstable plaque presenting as acute coronary syndrome (ACS) and Lp-PLA(2), and to assess the influence of statins on interpretation of Lp-PLA(2). A total of 362 consecutive patients presenting to the emergency department (ED) with acute chest pain suggestive of ACS were evaluated by cardiologists as STEMI, NSTEMI, or unstable angina, and non-ACS. Serum biomarkers measured on admission: troponin I, C-reactive protein (Abbott), and Lp-PLA(2) (DiaDexus). Four groups were defined according to the final diagnosis and history of statin medication: ACS/statin-; ACS/statin+; non-ACS/statin-; non-ACS/statin+. Lp-PLA(2) was highest in ACS/statin- group; statins decreased Lp-PLA(2) both in ACS and non-ACS of about 20 %. Lp-PLA(2) was higher in ACS patients in comparison with non-ACS patients group without respect to statin therapy (pPLA(2) predicted worse outcome (in terms of acute coronary syndrome) effectively in patients up to 62 years; limited prediction was found in older patients. C-reactive protein (CRP) failed to discriminate four groups of patients. Statin therapy and age should be taken into consideration while interpreting Lp-PLA(2) concentrations and lower cut-off values should be used for statin-treated persons.

LP 400-22, A Very Low Mass and High-Velocity White Dwarf

Science.gov (United States)

Kawka, Adela; Vennes, Stephane; Oswalt, Terry D.; Smith, J. Allyn; Silvestri, Nicole M.

2006-01-01

We report the identification of LP 400-22 (WD 2234+222) as a very low mass and high-velocity white dwarf. The ultraviolet GALEX and optical photometric colors and a spectral line analysis of LP 400-22 show this star to have an effective temperature of 11,080+/-140 K and a surface gravity of log g = 6.32 +/-0.08. Therefore, this is a helium-core white dwarf with a mass of 0.17 M,. The tangential velocity of this white dwarf is 414+/-43 km/s, making it one of the fastest moving white dwarfs known. We discuss probable evolutionary scenarios for this remarkable object.

77 FR 20871 - Praesidian Capital Opportunity Fund III, LP; License No. 02/02-0647; Notice Seeking Exemption...

Science.gov (United States)

2012-04-06

... contemplated to fund working capital and capital expenditures. The financing is brought within the purview of... SMALL BUSINESS ADMINISTRATION Praesidian Capital Opportunity Fund III, LP; License No. 02/02- 0647... given that Praesidian Capital Opportunity Fund III, LP, 419 Park Avenue South, New York, NY 10016, a...

75 FR 6414 - Cardinal Growth, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

Science.gov (United States)

2010-02-09

... SMALL BUSINESS ADMINISTRATION [License No. 05/75-0257] Cardinal Growth, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Cardinal Growth, L.P., 311 South Wacker Driver, Suite 5500, Chicago, IL 60606, a Federal...

78 FR 77770 - Ironwood Equity Fund, LP; Notice Seeking Exemption Under Section 312 of the Small Business...

Science.gov (United States)

2013-12-24

... proposes to Finance a small business in which its Associate Ironwood Mezzanine Fund II, LP has an equity... SMALL BUSINESS ADMINISTRATION [ License No. 01171-0406] Ironwood Equity Fund, LP; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby...

78 FR 62348 - Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing and Soliciting Motions...

Science.gov (United States)

2013-10-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7320-042] Erie Boulevard Hydropower, L.P.; Notice of Application Accepted for Filing and Soliciting Motions To Intervene and Protests.... Date filed: July 1, 2013. d. Applicant: Erie Boulevard Hydropower, L.P. e. Name of Project: Chasm...

Sib-pair analysis detects elevated Lp(a) levels and large variation of Lp(a) concentration in subjects with familial defective ApoB

NARCIS (Netherlands)

van der Hoek, Y. Y.; Lingenhel, A.; Kraft, H. G.; Defesche, J. C.; Kastelein, J. J.; Utermann, G.

1997-01-01

Whether or not Lp(a) plasma levels are affected by the apoB R3500Q mutation, which causes Familial Defective apoB (FDB), is still a matter of debate. We have analyzed 300 family members of 13 unrelated Dutch index patients for the apoB mutation and the apolipoprotein(a) [apo(a)] genotype. Total

Sparse filtering with the generalized lp/lq norm and its applications to the condition monitoring of rotating machinery

Science.gov (United States)

Jia, Xiaodong; Zhao, Ming; Di, Yuan; Li, Pin; Lee, Jay

2018-03-01

Sparsity is becoming a more and more important topic in the area of machine learning and signal processing recently. One big family of sparse measures in current literature is the generalized lp /lq norm, which is scale invariant and is widely regarded as normalized lp norm. However, the characteristics of the generalized lp /lq norm are still less discussed and its application to the condition monitoring of rotating devices has been still unexplored. In this study, we firstly discuss the characteristics of the generalized lp /lq norm for sparse optimization and then propose a method of sparse filtering with the generalized lp /lq norm for the purpose of impulsive signature enhancement. Further driven by the trend of industrial big data and the need of reducing maintenance cost for industrial equipment, the proposed sparse filter is customized for vibration signal processing and also implemented on bearing and gearbox for the purpose of condition monitoring. Based on the results from the industrial implementations in this paper, the proposed method has been found to be a promising tool for impulsive feature enhancement, and the superiority of the proposed method over previous methods is also demonstrated.

Variation in LPA is associated with Lp(a levels in three populations from the Third National Health and Nutrition Examination Survey.

Directory of Open Access Journals (Sweden)

Logan Dumitrescu

2011-01-01

Full Text Available The distribution of lipoprotein(a [Lp(a] levels can differ dramatically across diverse racial/ethnic populations. The extent to which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were genotyped in 7,159 participants from the Third National Health and Nutrition Examination Survey (NHANES III. NHANES III is a diverse population-based survey with DNA samples linked to hundreds of quantitative traits, including serum Lp(a. Tests of association between LPA variants and transformed Lp(a levels were performed across the three different NHANES subpopulations (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. At a significance threshold of p<0.0001, 15 of the 19 SNPs tested were strongly associated with Lp(a levels in at least one subpopulation, six in at least two subpopulations, and none in all three subpopulations. In non-Hispanic whites, three variants were associated with Lp(a levels, including previously known rs6919246 (p = 1.18 × 10(-30. Additionally, 12 and 6 variants had significant associations in non-Hispanic blacks and Mexican Americans, respectively. The additive effects of these associated alleles explained up to 11% of the variance observed for Lp(a levels in the different racial/ethnic populations. The findings reported here replicate previous candidate gene and genome-wide association studies for Lp(a levels in European-descent populations and extend these findings to other populations. While we demonstrate that LPA is an important contributor to Lp(a levels regardless of race/ethnicity, the lack of generalization of associations across all subpopulations suggests that specific LPA variants may be contributing to the observed Lp(a between-population variance.

The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease.

Science.gov (United States)

Lima, G M G; Corazza, B J M; Moraes, R M; de Oliveira, F E; de Oliveira, L D; Franco, G C N; Perrien, D S; Elefteriou, F; Anbinder, A L

2016-10-01

LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Previous work indicates that LP533401 has an anabolic effect in bone. Thus, we hypothesized that inhibition of gut serotonin production may modulate the host response in periodontal disease. In this study, we aimed to analyze the effects of LP533401 in a rat periodontitis model to evaluate the role of gut serotonin in periodontitis pathophysiology. Twenty-four rats were divided into three groups: treated group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by gavage; ligature group (L: ligature-induced periodontal disease only); and control group (C: without ligature-induced periodontal disease). After 28 d, radiographic alveolar bone support was measured on digital radiographs, and alveolar bone volume fraction, tissue mineral density and trabeculae characteristics were quantified by microcomputed tomography in the right hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss, attachment loss and area of collagen in the gingiva were histologically analyzed. Significant difference between the L and C groups was found, confirming that periodontal disease was induced. We observed no difference between the T and L groups regarding alveolar bone destruction and area of collagen. LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not modulate host response in a rat model of induced periodontal disease. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

78 FR 48177 - Purdue Pharma L.P.; Withdrawal of Approval of a New Drug Application for Oxycontin

Science.gov (United States)

2013-08-07

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2013-N-0883] Purdue Pharma L.P.; Withdrawal of Approval of a New Drug Application for Oxycontin AGENCY: Food and Drug... Purdue Pharma L.P. (Purdue), One Stamford Forum, Stamford, CT 06901-3431. Purdue has voluntarily...

77 FR 11618 - Solutions Capital I, L.P.; Notice Seeking Exemption Under the Small Business Investment Act...

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2012-02-27

... SMALL BUSINESS ADMINISTRATION [License No. 03/03-0247] Solutions Capital I, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Solutions Capital I, L.P., 1100 Wilson Blvd., Suite 3000, Arlington, VA 22209, a Federal Licensee under the...

76 FR 18210 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2011-04-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-138-000] Texas Eastern Transmission, LP; Notice of Application On March 15, 2011, Texas Eastern Transmission Corporation (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056-5310, filed with the Federal Energy Regulatory...

Prenatal exposure to a maternal LP diet decreases BDNF expression in the brains of the neonatal offspring

Science.gov (United States)

Maternal low protein (LP) diets during gestation cause learning and mernmy impai1ment as well as cognitive deficits in the neonatal and adult offsp1ing. The cellular and molecular mechanism that mediate the deleterious effects of prenatal exposure to a maternal LP diet on cognitive function is egreg...

78 FR 338 - Buckeye Hammond Railroad, L.L.C.; Acquisition and Operation Exemption; Buckeye Partners, L.P.

Science.gov (United States)

2013-01-03

... Railroad, L.L.C.; Acquisition and Operation Exemption; Buckeye Partners, L.P. Buckeye Hammond Railroad, L.L... acquire from Buckeye Partners, L.P., a noncarrier, and to operate approximately 6,797 feet (1.29 miles) of...: December 26, 2012. By the Board, Rachel D. Campbell, Director, Office of Proceedings. Jeffrey Herzig...

78 FR 4842 - Linden VFT, LLC v. Brookfield Energy Marketing, LP, Cargill Power Markets, LLC; Notice of Complaint

Science.gov (United States)

2013-01-23

... v. Brookfield Energy Marketing, LP, Cargill Power Markets, LLC; Notice of Complaint Take notice that... Brookfield Energy Marketing, LP and Cargill Power Markets, LLC (Respondents) alleging that, Respondents... subscribed docket(s). For assistance with any FERC Online service, please email [email protected

RANS simulation of the thermal mixing in HTTF LP during normal operation conditions – High Temperature Test Facility at Oregon State University

International Nuclear Information System (INIS)

Gradecka, Malwina J.; Woods, Brian

2014-01-01

Since High Temperature Gas-cooled Reactors are being considered as the most promising design of upcoming IV Gen reactors, key research areas were identified to address safety aspects of this design. A number of simulations and experiments need to be conducted in this field. In this paper, thermal-hydraulics aspects of coolant flow through Lower Plenum (LP) of HTGR were considered, specifically flow characteristics to identify the risk of temperature stratification in LP and hot spotting on LP floor. Local temperature gradients can cause material degradation. As the power profile is non-uniform across the core, jets of coolant exit the core region at different temperatures and enter the LP impinging on LP floor causing hot spots at LP structure and temperature stratification. To address those issues numerical simulation and an experiment are being developed. The numerical simulation provides coolant flow velocity and temperature fields. The purpose of this study is to investigate the mixing phenomenon in the LP due to risk of the hot streaking and thermal stratification phenomena during normal operation of HTTF. The following aspect are being examined: identification of gas flow behavior in lower plenum of HTTF based on CFD simulations, identification of hot streaking issue in the HTTF lower plenum using CFD tools, and computational investigation of gas mixing efficiency. This paper includes a description of experimental setup of HTTF, guidance for LP CFD modeling, and the results and analysis of CFD simulation. (author)

Norra LP-mudel ajab Eestis juuri / intervjueerinud Sirje Pärismaa

Index Scriptorium Estoniae

2016-01-01

Teaduspõhise LP-mudeli (Learning environment and pedagogical analysis) - abivahendi koolikultuuri parandamiseks ja süsteemsemaks lähenemiseks tekkinud probleemidele - on kasutusele võtnud 10 kooli ja 3 lasteaeda. Norra hariduseksperdid Janne Stoen ja Hanna Jahnsen vastasid Õpetajate Lehe küsimustele

78 FR 64933 - Texas Eastern Transmission, LP; Notice of Application

Science.gov (United States)

2013-10-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-4-000] Texas Eastern Transmission, LP; Notice of Application Take notice that on October 10, 2013, Texas Eastern Transmission, (Texas Eastern), having its principal place of business at 5400 Westheimer Court, Houston, Texas, 77056...

Defense Meteorological Satellite Program (DMSP) Film

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The United States Air Force Defense Meteorological Satellite Program (DMSP) Operational Linescan System (OLS) is a polar orbiting meteorological sensor with two...

LOFT/LP-LB-1, Loss of Fluid Test, Large-Break LOCA Experiment

International Nuclear Information System (INIS)

1989-01-01

1 - Description of test facility: The LOFT Integral Test Facility is a scale model of a LPWR. The intent of the facility is to model the nuclear, Thermal-hydraulic phenomena which would take place in a LPWR during a LOCA. The general philosophy in scaling coolant volumes and flow areas in LOFT was to use the ratio of the LOFT core [50 MW(t)] to a typical LPWR core [3000 MW(t)]. For some components, this factor is not applied; however, it is used as extensively as practical. In general, components used in LOFT are similar in design to those of a LPWR. Because of scaling and component design, the LOFT LOCE is expected to closely model a LPWR LOCA. 2 - Description of test: Experiment LP-LB-1 was conducted on 3 February 1984 in the Loss-of-Fluid Test (LOFT) facility at the Idaho National Engineering Laboratory under the auspices of the Organization for Economic Cooperation and Development. The primary objectives of Experiment LP-LB-1 were to determine system transient characteristics and to assess code predictive capabilities for design basis large-break loss-of-coolant accidents in pressurized water reactors (PWRs). This experiment simulated a double-ended offset shear of one inlet pipe in a four-loop PWR and was initiated from conditions representative of licensing limits in a PWR. Other boundary conditions for the simulation were loss of offsite power, rapid primary coolant pump coast down, and United Kingdom minimum safeguard emergency core coolant injection rates. The nuclear fuel rods were not pressurized. The transient was initiated by opening the quick-opening blowdown valves in the broken loop hot and cold legs. 3 - Experimental limitations or shortcomings: Short core and steam generator, excessive core bypass, other scaling compromises, and lack of adequate measurements in certain areas

Deploying Missile Defense: Major Operational Challenges

National Research Council Canada - National Science Library

Bunn, M

2004-01-01

By October 2004, the United States will have begun initial deployment of a missile defense capability albeit a modest, limited, and not completely proven one to defend the homeland against a limited...

75 FR 79065 - Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice Seeking Exemption Under...

Science.gov (United States)

2010-12-17

... 95113. The financing is contemplated for working capital and general operating purposes. The financing... SMALL BUSINESS ADMINISTRATION Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice... hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo, CA 94402...

75 FR 39588 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2010-07-09

..., San Jose, California 95113. The financing is contemplated for working capital and general operating... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

76 FR 76474 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2011-12-07

..., Emeryville, CA 94608 (``Lithium''). The financing is contemplated for working capital and general operating... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

76 FR 1491 - Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice Seeking Exemption Under...

Science.gov (United States)

2011-01-10

... financing is contemplated for working capital and general operating purposes. The financing is brought... SMALL BUSINESS ADMINISTRATION Emergence Capital Partners SBIC, L.P. License No. 09/79-0454; Notice... hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo, CA 94402...

76 FR 28843 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2011-05-18

... 94404. The financing is contemplated for working capital and general operating purposes. The financing... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

75 FR 32230 - Emergence Capital Partners SBIC, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2010-06-07

... is contemplated for working capital and general operating purposes. The financing is brought within... SMALL BUSINESS ADMINISTRATION [License No. 09/79-0454] Emergence Capital Partners SBIC, L.P... Notice is hereby given that Emergence Capital Partners SBIC, L.P., 160 Bovet Road, Suite 300, San Mateo...

75 FR 32230 - Solutions Capital I, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

Science.gov (United States)

2010-06-07

... working capital and general corporate purposes. The financing is brought within the purview of Sec. 107... SMALL BUSINESS ADMINISTRATION [License No. 03/03-0247] Solutions Capital I, L.P.; Notice Seeking... given that Solutions Capital I, L.P., 1100 Wilson Blvd., Suite 3000, Arlington, VA 22209, a Federal...

78 FR 78350 - Houston Pipe Line Company, LP; Notice of Intent to Prepare an Environmental Assessment for the...

Science.gov (United States)

2013-12-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP14-13-000] Houston Pipe Line Company, LP; Notice of Intent to Prepare an Environmental Assessment for the Proposed 24-Inch... Hidalgo County, Texas by Houston Pipe Line Company, LP (HPL). The Commission will use this EA in its...

75 FR 3502 - KLH Capital, L.P.; Notice Seeking Exemption Under 312 of the Small Business Investment Act...

Science.gov (United States)

2010-01-21

... SMALL BUSINESS ADMINISTRATION [License No. 04/04-0296] KLH Capital, L.P.; Notice Seeking Exemption Under 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that KLH Capital, L.P., 101 East Kennedy Boulevard, Suite 3925, Tampa, Florida 33602, a Federal Licensee under the...

The obesity and fatty liver are reduced by plant-derived Pediococcus pentosaceus LP28 in high fat diet-induced obese mice.

Directory of Open Access Journals (Sweden)

Xingrong Zhao

Full Text Available We evaluated the effect of an oral administration of a plant-derived lactic acid bacterium, Pediococcus pentosaceus LP28 (LP28, on metabolic syndrome by using high fat diet-induced obese mice. The obese mice were divided into 2 groups and fed either a high fat or regular diet for 8 weeks. Each group was further divided into 3 groups, which took LP28, another plant-derived Lactobacillus plantarum SN13T (SN13T or no lactic acid bacteria (LAB. The lean control mice were fed a regular diet without inducing obesity prior to the experiment. LP28 reduced body weight gain and liver lipid contents (triglyceride and cholesterol, in mice fed a high fat diet for 8 weeks (40%, 54%, and 70% less than those of the control group without LAB, and P = 0.018, P<0.001, and P = 0.021, respectively, whereas SN13T and the heat treated LP28 at 121°C for 15 min were ineffective. Abdominal visceral fat in the high fat diet mice fed with LP28 was also lower than that without LAB by 44%, although it was not significant but borderline (P = 0.076. The sizes of the adipocytes and the lipid droplets in the livers were obviously decreased. A real-time PCR analyses showed that lipid metabolism-related genes, such as CD36 (P = 0.013, SCD1 encoding stearoyl-CoA desaturase 1 (not significant but borderline, P = 0.066, and PPARγ encoding peroxisome proliferator-activated receptor gamma (P = 0.039, were down-regulated by taking LP28 continuously, when compared with those of the control group. In conclusion, LP28 may be a useful LAB strain for the prevention and reduction of the metabolic syndrome.

IS30-related transposon mediated insertional inactivation of bile salt hydrolase (bsh1) gene of Lactobacillus plantarum strain Lp20.

Science.gov (United States)

Kumar, Rajesh; Grover, Sunita; Kaushik, Jai K; Batish, Virender Kumar

2014-01-01

Lactobacillus plantarum is a flexible and versatile microorganism that inhabits a variety of niches, and its genome may express up to four bsh genes to maximize its survival in the mammalian gut. However, the ecological significance of multiple bsh genes in L. plantarum is still not clearly understood. Hence, this study demonstrated the disruption of bile salt hydrolase (bsh1) gene due to the insertion of a transposable element in L. plantarum Lp20 - a wild strain of human fecal origin. Surprisingly, L. plantarum strain Lp20 produced a ∼2.0 kb bsh1 amplicon against the normal size (∼1.0 kb) bsh1 amplicon of Bsh(+)L. plantarum Lp21. Strain Lp20 exhibited minimal Bsh activity in spite of having intact bsh2, bsh3 and bsh4 genes in its genome and hence had a Bsh(-) phenotype. Cloning and sequence characterization of Lp20 bsh1 gene predicted four individual open reading frames (ORFs) within this region. BLAST analysis of ORF1 and ORF2 revealed significant sequence similarity to the L. plantarum bsh1 gene while ORF3 and ORF4 showed high sequence homology to IS30-family transposases. Since, IS30-related transposon element was inserted within Lp20 bsh1 gene in reverse orientation (3'-5'), it introduced several stop codons and disrupted the protein reading frames of both Bsh1 and transposase. Inverted terminal repeats (GGCAGATTG) of transposon, mediated its insertion at 255-263 nt and 1301-1309 nt positions of Lp20 bsh1 gene. In conclusion, insertion of IS30 related-transposon within the bsh1 gene sequence of L. plantarum strain Lp20 demolished the integrity and functionality of Bsh1 enzyme. Additionally, this transposon DNA sequence remains active among various Lactobacillus spp. and hence harbors the potential to be explored in the development of efficient insertion mutagenesis system. Copyright © 2013 Elsevier GmbH. All rights reserved.

75 FR 28657 - Dell Products LP-Parmer North Location, a Subsidiary of Dell, Inc., Including On-Site Leased...

Science.gov (United States)

2010-05-21

... Spherion Corporation; Round Rock, TX; Dell Products LP--Parmer North One; Austin, TX; Amended Certification... Products LP--Parmer North Location, a Subsidiary of Dell, Inc., Including On-Site Leased Workers From... Act of 1974, as amended (``Act''), 19 U.S.C. 2273, the Department of Labor issued a Certification of...

76 FR 36910 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

Science.gov (United States)

2011-06-23

... Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC... Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power [[Page... subscribed docket(s). For assistance with any FERC Online service, please e-mail [email protected

Development of a methodology for conducting an integrated HRA/PRA --. Task 1, An assessment of human reliability influences during LP&S conditions PWRs

Energy Technology Data Exchange (ETDEWEB)

Luckas, W.J.; Barriere, M.T.; Brown, W.S. [Brookhaven National Lab., Upton, NY (United States); Wreathall, J. [Wreathall (John) and Co., Dublin, OH (United States); Cooper, S.E. [Science Applications International Corp., McLean, VA (United States)

1993-06-01

During Low Power and Shutdown (LP&S) conditions in a nuclear power plant (i.e., when the reactor is subcritical or at less than 10--15% power), human interactions with the plant`s systems will be more frequent and more direct. Control is typically not mediated by automation, and there are fewer protective systems available. Therefore, an assessment of LP&S related risk should include a greater emphasis on human reliability than such an assessment made for power operation conditions. In order to properly account for the increase in human interaction and thus be able to perform a probabilistic risk assessment (PRA) applicable to operations during LP&S, it is important that a comprehensive human reliability assessment (HRA) methodology be developed and integrated into the LP&S PRA. The tasks comprising the comprehensive HRA methodology development are as follows: (1) identification of the human reliability related influences and associated human actions during LP&S, (2) identification of potentially important LP&S related human actions and appropriate HRA framework and quantification methods, and (3) incorporation and coordination of methodology development with other integrated PRA/HRA efforts. This paper describes the first task, i.e., the assessment of human reliability influences and any associated human actions during LP&S conditions for a pressurized water reactor (PWR).

Defense.gov Special Report: Memorial Day 2012

Science.gov (United States)

information so we can address your issue or question. United States Department of Defense United States Veterans Past, Present on Memorial Day Obama: Memorial Day Honors the Fallen 'Flags In' Tradition Honors Blog: Everyone Can Find A Way to Honor our Service Members Over the past few years, I have been blessed

Antiglycopeptide Mouse Monoclonal Antibody LpMab-21 Exerts Antitumor Activity Against Human Podoplanin Through Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity.

Science.gov (United States)

Kato, Yukinari; Kunita, Akiko; Fukayama, Masashi; Abe, Shinji; Nishioka, Yasuhiko; Uchida, Hiroaki; Tahara, Hideaki; Yamada, Shinji; Yanaka, Miyuki; Nakamura, Takuro; Saidoh, Noriko; Yoshida, Kanae; Fujii, Yuki; Honma, Ryusuke; Takagi, Michiaki; Ogasawara, Satoshi; Murata, Takeshi; Kaneko, Mika K

2017-02-01

The interaction between podoplanin (PDPN) and C-type lectin-like receptor 2 (CLEC-2) is involved in tumor malignancy. We have established many monoclonal antibodies (mAbs) against human podoplanin using the cancer-specific mAb (CasMab) technology. LpMab-21, one of the mouse antipodoplanin mAbs, is of the IgG 2a subclass, and its minimum epitope was determined to be Thr76-Arg79 of the human podoplanin. Importantly, sialic acid is linked to Thr76; therefore, LpMab-21 is an antiglycopeptide mAb (GpMab). In this study, we investigated whether LpMab-21 shows antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against human podoplanin-expressing cancer cell lines in vitro and also studied its antitumor activities using a xenograft model. LpMab-21 showed high ADCC and CDC activities against not only podoplanin-expressing Chinese hamster ovary cells but also LN319 glioblastoma cells and PC-10 lung cancer cells, both of which endogenously express podoplanin. Furthermore, LpMab-21 decreased tumor growth in vivo, indicating that LpMab-21 could be useful for antibody therapy against human podoplanin-expressing cancers.

76 FR 34692 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

Science.gov (United States)

2011-06-14

... Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC... Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC... notification when a document is added to a subscribed docket(s). For assistance with any FERC Online service...

The antimicrobial lysine-peptoid hybrid LP5 inhibits DNA replication and induces the SOS response in Staphylococcus aureus

DEFF Research Database (Denmark)

Gottschalk, Sanne; Ifrah, Dan; Lerche, Sandra

2013-01-01

the growth of S. aureus without ATP leakage. Instead, LP5 bound DNA and inhibited macromolecular synthesis. The binding to DNA also led to inhibition of DNA gyrase and topoisomerase IV and caused induction of the SOS response. CONCLUSIONS: Our data demonstrate that LP5 may have a dual mode of action against...

The Development of the US National Missile Defense and its Impact on the International Security

Directory of Open Access Journals (Sweden)

J. Yu. Parshkova

2015-01-01

Full Text Available The article reflects the US officials' point of view on the development of its national missile defense. The major threat to international security is the proliferation of ballistic missiles and weapons of mass destruction. The United States and the former Soviet Union made huge efforts to reduce and limit offensive arms. However, presently the proliferation of ballistic missiles spreads all over the world, especially in the Middle East, because of the ballistic missile technology falling into the hands of hostile non-state groups. Missile defenses can provide a permanent presence in a region and discourage adversaries from believing they can use ballistic missiles to coerce or intimidate the U.S. or its allies. With the possible attack regional missile defense systems will be promptly mobilized to enhance an effective deterrent. The ultimate goal of such large-scale missile defense deployment is to convince the adversaries that the use of ballistic missiles is useless in military terms and that any attack on the United States and its allies is doomed to failure. The United States has missile defense cooperative programs with a number of allies, including United Kingdom, Japan, Australia, Israel, Denmark, Germany, Netherlands, Czech Republic, Poland, Italy and many others. The Missile Defense Agency also actively participates in NATO activities to maximize opportunities to develop an integrated NATO ballistic missile defense capability. The initiative of the development of US BMD naturally belongs to the United States. That country has enormous technological, financial, economic, military and institutional capabilities, exceeding by far those of the other NATO members combined.

Relative expression of bacterial and host specific genes associated with probiotic survival and viability in the mice gut fed with Lactobacillus plantarum Lp91.

Science.gov (United States)

Chandran, Archana; Duary, Raj Kumar; Grover, Sunita; Batish, Virender Kumar

2013-11-07

The present investigation was aimed at studying the relative expression of atpD (a key part of F1F0-ATPase operon), bsh (bile salt hydrolase), mub (mucus-binding protein) and MUC2 (mucin) genes in mouse model for establishing the in vivo functional efficacy of Lactobacillus plantarum Lp91 (MTCC5690) by reverse transcription-quantitative PCR (RT-qPCR). The atpD gene was significantly up-regulated to 2.0, 2.4 and 3.2 folds in Lp91 after 15, 30 and 60 min transit in the stomach of mice. The maximal significant (Pstrain Lp5276 after seven days of mice feeding. Simultaneously, mub gene expression increased to 12.8 and 22.7 fold in both Lp91 and Lp5276, respectively. The expression level of MUC2 was at the level of 1.6 and 2.1 fold in the host colon on administration with Lp91 and Lp5276 feeding, respectively. Hence, the expression of atpD, bsh, mub, MUC2 could be considered as prospective and potential biomarkers for screening of novel probiotic lactobacillus strains for optimal functionality in the gut. Copyright © 2013 Elsevier GmbH. All rights reserved.

Searching the Skies: the Legacy of the United States Cold War Defense Radar Program

National Research Council Canada - National Science Library

Winkler, David

1997-01-01

The Department of Defense (DOD) Legacy Resource Management Program was established under the Defense Appropriations Act of 1991 to determine how to better integrate the conservation of irreplaceable biological, cultural...

Liquid-phase problems in steam turbine LP stages

International Nuclear Information System (INIS)

Blanc-Feraud, P.

1978-01-01

Wet steam formation owing to incipient condensation in final steam turbine pressure stages results in a loss of efficiency and possible rotor blading erosion. The effects of erosion are now clearly understood and quite easily counteracted, but loss of thermodynamics, mechanical and aerodynamic efficiency is still a problem. Only the final LP stages of conventional power station plant operate with wet steam, whereas nuclear plant turbines use it to produce most of their total output [fr

75 FR 45611 - Texas Eastern Transmission LP; Notice of Application

Science.gov (United States)

2010-08-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP10-471-000] Texas Eastern Transmission LP; Notice of Application July 27, 2010. Take notice that on July 15, 2010, Texas Eastern Transmission (Texas Eastern), P.O. Box 1642, Houston, Texas 77251-1642, filed in Docket No. CP10-471-000, an...

Characterizing the Resolved M6 Dwarf Twin LP 318-218AB

Science.gov (United States)

Moreno Hilario, Elizabeth; Burgasser, Adam J.; Bardalez Gagliuffi, Daniella; Tamiya, Tomoki

2017-01-01

The lowest-mass stars and brown dwarfs are among the most common objects in the Milky Way Galaxy, but theories of their formation and evolution remain poorly constrained. Binary systems are important for understanding the formation of these objects and for making direct orbit and mass measurements to validate evolutionary theories. We report the discovery of LP 318-218, a high proper motion late M dwarf, as a near equal-brightness binary system with a separation of 0.72 arcseconds. Resolved near-infrared spectroscopy confirms the components as nearly identical M6 twins. We using our resolved photometry and spectroscopy to estimate the distance, projected separation and tangential velocity of the system, and confirm common proper motion. We also perform atmosphere model fits to the resolved spectra to assess their physical properties. We place LP 318-218 in context with other widely-separated late M dwarf binaries.

Safety analysis report: packages. LP-12 tritium package (packaging of fissile and other radioactive materials). Final report

International Nuclear Information System (INIS)

Gates, A.A.; McCarthy, P.G.; Edl, J.W.

1975-05-01

Elemental tritium is shipped at low pressure in a stainless steel container (LP-12) within an aluminum vessel and surrounded by 3.9 in.-thick Celotex insulation in a steel drum. Information is presented on the packaging design, evaluation of the structural, thermal, containment, shielding, and criticality characteristics of the package, procedures for loading, unloading, transporting, and testing the LP-12, and quality assurance requirements. (U.S.)

LP DAAC MEaSUREs Project Artifact Tracking Via the NASA Earthdata Collaboration Environment

Science.gov (United States)

Bennett, S. D.

2015-12-01

The Land Processes Distributed Active Archive Center (LP DAAC) is a NASA Earth Observing System (EOS) Data and Information System (EOSDIS) DAAC that supports selected EOS Community non-standard data products such as the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) Global Emissivity Database (GED), and also supports NASA Earth Science programs such as Making Earth System Data Records for Use in Research Environments (MEaSUREs) to contribute in providing long-term, consistent, and mature data products. As described in The LP DAAC Project Lifecycle Plan (Daucsavage, J.; Bennett, S., 2014), key elements within the Project Inception Phase fuse knowledge between NASA stakeholders, data producers, and NASA data providers. To support and deliver excellence for NASA data stewardship, and to accommodate long-tail data preservation with Community and MEaSUREs products, the LP DAAC is utilizing NASA's own Earthdata Collaboration Environment to bridge stakeholder communication divides. By leveraging a NASA supported platform, this poster describes how the Atlassian Confluence software combined with a NASA URS/Earthdata support can maintain each project's members, status, documentation, and artifact checklist. Furthermore, this solution provides a gateway for project communities to become familiar with NASA clients, as well as educating the project's NASA DAAC Scientists for NASA client distribution.

75 FR 76037 - HAVI Logistics, North America a Subsidiary of HAVI Group, LP Including On-Site Leased Workers of...

Science.gov (United States)

2010-12-07

... Logistics, North America a Subsidiary of HAVI Group, LP Including On-Site Leased Workers of Express Personnel Services and the La Salle Network, Bloomingdale, IL; Havi Logistics, North America, Lisle, IL..., applicable to workers of HAVI Logistics, North America, a subsidiary of HAVI Group, LP, including on-site...

77 FR 42353 - Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2012-07-18

... Regulations because Escalate Capital Partners SBIC I, L.P. proposes to Finance a small business in which its... SMALL BUSINESS ADMINISTRATION [License No. 06/06-0335] Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest...

76 FR 17180 - KLH Capital II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment...

Science.gov (United States)

2011-03-28

... SMALL BUSINESS ADMINISTRATION [License No. 04/04-0296] KLH Capital II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that KLH Capital, L.P., 101 East Kennedy Boulevard, Suite 3925, Tampa, FL, 33602 a Federal...

Economics of defense high-level waste management in the United States

International Nuclear Information System (INIS)

Slate, S.C.; McDonell, W.R.

1987-01-01

The Department of Energy (DOE) is responsible for managing defense high-level wastes (DHLW) from U.S. defense activities using environmentally safe and cost-effective methods. In parallel with its technical programs, the DOE is performing economic studies to ensure that costs are minimized. To illustrate the cost estimating techniques and to provide a sense of cost magnitude, the DHLW costs for the Savannah River Plant (SRP) are calculated. Since operations at SRP must be optimized within relatively fixed management practices, the estimation of incremental costs is emphasized. Treatment and disposal costs are shown to equally contribute to the incremental cost of almost $400,000/canister

Soviet civil defense is inadequate and meaningless

International Nuclear Information System (INIS)

Kaplan, F.M.

1985-01-01

In this paper, the author argues that Soviet civil defense plans exist primarily on paper and are used to pacify the Soviet people, not as plans to survive and prevail in a nuclear confrontation with the U.S. The author describes how the Soviet people have little faith in the civil defense programs. They don't believe they can survive an attack. Furthermore, he says the Soviets have never staged an evacuation exercise in any major city nor, even in smaller towns, has an entire community been evacuated. The author says there are numerous problems with the shelter programs as well. Very few existing shelters have any food stocks, only a few more have any water. There is little evidence that Soviet leaders have planned their economy with civil defense in mind. Nor - given the blatant inadequacies of Soviet civil defense programs, the marked vulnerabilities of the Soviet economy, and the intrinsic limitation and uncertainties about civil defense generally - is there much basis for claiming that Soviet leaders, even in desperate straits, would risk war with the United States while counting on civil defense measures to limit the damage wreaked on the Soviet Union

Study on the mechanism and efficiency of simulated annealing using an LP optimization benchmark problem - 113

International Nuclear Information System (INIS)

Qianqian, Li; Xiaofeng, Jiang; Shaohong, Zhang

2010-01-01

Simulated Annealing Algorithm (SAA) for solving combinatorial optimization problems is a popular method for loading pattern optimization. The main purpose of this paper is to understand the underlying search mechanism of SAA and to study its efficiency. In this study, a general SAA that employs random pair exchange of fuel assemblies to search for the optimum fuel Loading Pattern (LP) is applied to an exhaustively searched LP optimization benchmark problem. All the possible LPs of the benchmark problem have been enumerated and evaluated via the use of the very fast and accurate Hybrid Harmonics and Linear Perturbation (HHLP) method, such that the mechanism of SA for LP optimization can be explicitly analyzed and its search efficiency evaluated. The generic core geometry itself dictates that only a small number LPs can be generated by performing random single pair exchanges and that the LPs are necessarily mostly similar to the initial LP. This phase space effect turns out to be the basic mechanism in SAA that can explain its efficiency and good local search ability. A measure of search efficiency is introduced which shows that the stochastic nature of SAA greatly influences the variability of its search efficiency. It is also found that using fuel assembly k-infinity distribution as a technique to filter the LPs can significantly enhance the SAA search efficiency. (authors)

78 FR 32294 - Escalate Capital Partners SBIC I, L.P., License No. 06/06-0335; Notice Seeking Exemption Under...

Science.gov (United States)

2013-05-29

..., Suite 309, Austin, TX 78730. The financing is contemplated to provide working capital. The financing is... SMALL BUSINESS ADMINISTRATION Escalate Capital Partners SBIC I, L.P., License No. 06/06-0335... Notice is hereby given that Escalate Capital Partners, SBIC I, L.P., 300 W. 6th Street, Suite 2250...

76 FR 68803 - Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2011-11-07

... Courtyard Drive, Suite 309, Austin, TX 78730. The financing is contemplated to provide working capital and... SMALL BUSINESS ADMINISTRATION [License No. 06/06-0335] Escalate Capital Partners SBIC I, L.P... Notice is hereby given that Escalate Capital Partners, SBIC I, L.P., 300 W. 6th Street, Suite 2250...

Lp(a-cholesterol is associated with HDL-cholesterol in overweight and obese African American children and is not an independent risk factor for CVD

Directory of Open Access Journals (Sweden)

Sharma Sushma

2012-01-01

Full Text Available Abstract Background The role of Lipoprotein (a cholesterol {Lp(a-C}as an additional and/or independent risk factor for cardiovascular disease (CVD is not clear. We evaluated the associations between Lp(a-C and other CVD risk factors including plasma lipoprotein concentrations and body fatness in overweight and obese African American children. Methods A cross-sectional analysis was carried out using data from a sample of 121 African American children aged 9-11 years with Body Mass Index (BMI's greater than the 85th percentile. Body height, weight and waist circumference (WC were measured. Fasting plasma concentrations of Lp(a-C, Total cholesterol (TC, High density lipoprotein cholesterol (HDL-C, Very low density lipoprotein cholesterol (VLDL-C, Intermediate density lipoprotein cholesterol (IDL-C, Low density lipoprotein cholesterol (LDL-C, and Triacylglycerides (TAG were analyzed using the vertical auto profile (VAP cholesterol method. Results After adjusting for child age, gender, and pubertal status, Lp(a-C was positively associated with both HDL-C and TC, and negatively associated with VLDL-C and TAG. Including BMIz and WC as additional covariates did not alter the direction of the relationships between Lp(a-C and the other lipoproteins. Finally, after adjusting for the other plasma lipoproteins, Lp(a-C remained strongly associated with HDL-C, whereas the associations of Lp(a-C with the other lipoproteins were not significant when HDL-C was simultaneously included in the regression models. Conclusions Lp(a-C was positively associated with HDL-C and this association is not influenced by other lipoprotein subclasses or by the degree of obesity. We conclude that Lp(a cholesterol is not an independent risk factor for CVD in African American children.

77 FR 22773 - Texas Eastern Transmission, L.P.; Notice of Response

Science.gov (United States)

2012-04-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. RP12-318-001] Texas Eastern... order of the Federal Energy Regulatory Commission in the above- captioned proceeding Texas Eastern Transmission, LP (Texas Eastern) submits its response to show cause why it should not be required to file...

TRAC-PF1 MOD1 post test calculations of the OECD LOFT Experiment LP-SB-1

International Nuclear Information System (INIS)

Allen, E.J.

1990-04-01

Analysis of the small, hot leg break, OECD LOFT Experiment LP-SB-1. using the ''best-estimate'' computer code TRAC-PF1/MOD1 is presented. Descriptions of the LOFT facility and the LP-SB-1 experiment are given and development of the TRAC-PF1/MOD1 input model is detailed. The calculations performed in achieving the steady state conditions, from which the experiment was initiated, and the specification of experimental boundary conditions are outlined. 24 refs., 66 figs., 12 tabs

Håndbog i praktisk hjælp eBog

DEFF Research Database (Denmark)

René, Michael

Håndbog i praktisk hjælp er en opslagsbog med masser af nyttig viden om rengøring, hygiejne og opbevaring af fødevarer. Bogen indeholder afsnit om forskellige rengøringsmidler, om rengøring af forskellige materialer og om fjernelse af pletter, og der er en beskrivelse af forholdsregler i forbinde......://michaelrene.com/forfatter/ Anmeldelse: http://www.michaelrene.com/Munksgaard/AnmeldelseHaandbogIpraktiskhjaelp.png...

Håndbog i praktisk hjælp iBog

DEFF Research Database (Denmark)

René, Michael

Håndbog i praktisk hjælp er en opslagsbog med masser af nyttig viden om rengøring, hygiejne og opbevaring af fødevarer. Bogen indeholder afsnit om forskellige rengøringsmidler, om rengøring af forskellige materialer og om fjernelse af pletter, og der er en beskrivelse af forholdsregler i forbinde......://michaelrene.com/forfatter/ Anmeldelse: http://www.michaelrene.com/Munksgaard/AnmeldelseHaandbogIpraktiskhjaelp.png...

The Leptospiral Antigen Lp49 is a Two-Domain Protein with Putative Protein Binding Function

Energy Technology Data Exchange (ETDEWEB)

Oliveira Giuseppe,P.; Oliveira Neves, F.; Nascimento, A.; Gomes Guimaraes, B.

2008-01-01

Pathogenic Leptospira is the etiological agent of leptospirosis, a life-threatening disease that affects populations worldwide. Currently available vaccines have limited effectiveness and therapeutic interventions are complicated by the difficulty in making an early diagnosis of leptospirosis. The genome of Leptospira interrogans was recently sequenced and comparative genomic analysis contributed to the identification of surface antigens, potential candidates for development of new vaccines and serodiagnosis. Lp49 is a membrane-associated protein recognized by antibodies present in sera from early and convalescent phases of leptospirosis patients. Its crystal structure was determined by single-wavelength anomalous diffraction using selenomethionine-labelled crystals and refined at 2.0 Angstroms resolution. Lp49 is composed of two domains and belongs to the all-beta-proteins class. The N-terminal domain folds in an immunoglobulin-like beta-sandwich structure, whereas the C-terminal domain presents a seven-bladed beta-propeller fold. Structural analysis of Lp49 indicates putative protein-protein binding sites, suggesting a role in Leptospira-host interaction. This is the first crystal structure of a leptospiral antigen described to date.

Defense Primer: Procurement

Science.gov (United States)

2017-02-10

Usually, incremental funding is used to mitigate peaks and valleys in annual budgets caused by the cost of one item significantly changing the...base defense budget . DOD uses these funds to buy several different types of materiel, including  new items easily recognizable as military...pursues a policy of full funding for procurement, meaning that the total estimated cost of each unit must be funded in the year it is budgeted . In a

Safety analysis report: packages. LP-50 tritium package (packaging of fissile and other radioactive materials). Final report

International Nuclear Information System (INIS)

Gates, A.A.; McCarthy, P.G.; Edl, J.W.

1975-04-01

Elemental tritium is shipped at low pressure in a stainless steel container (LP-50) sealed within an aluminum vessel and surrounded by a minimum of 4-in. thick Celotex insulation in a steel drum. The structural, thermal, containment, shielding, and criticality safety aspects of this package are evaluated. Procedures for loading and unloading, empty cask transport, acceptance testing and maintenance, and quality assurance requirements for the LP-50 package are described in detail. (U.S.)

Training Lp norm multiple kernel learning in the primal.

Science.gov (United States)

Liang, Zhizheng; Xia, Shixiong; Zhou, Yong; Zhang, Lei

2013-10-01

Some multiple kernel learning (MKL) models are usually solved by utilizing the alternating optimization method where one alternately solves SVMs in the dual and updates kernel weights. Since the dual and primal optimization can achieve the same aim, it is valuable in exploring how to perform Lp norm MKL in the primal. In this paper, we propose an Lp norm multiple kernel learning algorithm in the primal where we resort to the alternating optimization method: one cycle for solving SVMs in the primal by using the preconditioned conjugate gradient method and other cycle for learning the kernel weights. It is interesting to note that the kernel weights in our method can obtain analytical solutions. Most importantly, the proposed method is well suited for the manifold regularization framework in the primal since solving LapSVMs in the primal is much more effective than solving LapSVMs in the dual. In addition, we also carry out theoretical analysis for multiple kernel learning in the primal in terms of the empirical Rademacher complexity. It is found that optimizing the empirical Rademacher complexity may obtain a type of kernel weights. The experiments on some datasets are carried out to demonstrate the feasibility and effectiveness of the proposed method. Copyright © 2013 Elsevier Ltd. All rights reserved.

Spatiotemporal profiles of receptive fields of neurons in the lateral posterior nucleus of the cat LP-pulvinar complex.

Science.gov (United States)

Piché, Marilyse; Thomas, Sébastien; Casanova, Christian

2015-10-01

The pulvinar is the largest extrageniculate thalamic visual nucleus in mammals. It establishes reciprocal connections with virtually all visual cortexes and likely plays a role in transthalamic cortico-cortical communication. In cats, the lateral posterior nucleus (LP) of the LP-pulvinar complex can be subdivided in two subregions, the lateral (LPl) and medial (LPm) parts, which receive a predominant input from the striate cortex and the superior colliculus, respectively. Here, we revisit the receptive field structure of LPl and LPm cells in anesthetized cats by determining their first-order spatiotemporal profiles through reverse correlation analysis following sparse noise stimulation. Our data reveal the existence of previously unidentified receptive field profiles in the LP nucleus both in space and time domains. While some cells responded to only one stimulus polarity, the majority of neurons had receptive fields comprised of bright and dark responsive subfields. For these neurons, dark subfields' size was larger than that of bright subfields. A variety of receptive field spatial organization types were identified, ranging from totally overlapped to segregated bright and dark subfields. In the time domain, a large spectrum of activity overlap was found, from cells with temporally coinciding subfield activity to neurons with distinct, time-dissociated subfield peak activity windows. We also found LP neurons with space-time inseparable receptive fields and neurons with multiple activity periods. Finally, a substantial degree of homology was found between LPl and LPm first-order receptive field spatiotemporal profiles, suggesting a high integration of cortical and subcortical inputs within the LP-pulvinar complex. Copyright © 2015 the American Physiological Society.

A comparison of P-3 and LP-3 distribution of peak floods at guddu barrage on indus river

International Nuclear Information System (INIS)

Memon, A.G.

2007-01-01

In this paper P-3 (Pearson-3) and LP-3 (Log-Pearson-3) distributions are fitted on the data of flood peaks at Guddu, for 38 years (1962-1999), Using three methods of estimation namely MOM (Method Of Moments), KLM (Maximum Likelihood Method) and PWM (Power weighted moment). LP-3 distribution appears to be appropriate for modeling the flood data on the basis of i-test, S-K (Simirnov- Kolmogrov) test, Cs (Coefficient of Skewness), RMSE (Root Mean Square Errors), PPCC (Probability Plot Correlation Coefficient) and L-Moment Ratios. MLM is found to be the efficient method. 1.52 million cusecs flood is expected to arrive at Guddu barrage, during next 100 years, when LP-3 distribution is fitted by MLM, i.e. 37% more than its designed capacity of 1.1 million cusecs. (author)

Bivalent rLP2086 Vaccine (Trumenba(®)): A Review in Active Immunization Against Invasive Meningococcal Group B Disease in Individuals Aged 10-25 Years.

Science.gov (United States)

Shirley, Matt; Dhillon, Sohita

2015-10-01

Bivalent rLP2086 vaccine (Trumenba(®)) [hereafter referred to as rLP2086] is a Neisseria meningitidis serogroup B (MenB) vaccine recently licensed in the USA for active immunization to prevent invasive disease caused by MenB in individuals 10-25 years of age. rLP2086, which contains two variants of the meningococcal surface protein factor H-binding protein (fHBP), was approved by the FDA under the accelerated approval pathway after the immunogenicity of the vaccine was demonstrated in several phase II trials. This article reviews the immunogenicity and reactogenicity of rLP2086 as demonstrated in the trials with a focus on the US setting and on use of the vaccine as per FDA-approved labeling. rLP2086 is approved in the USA as a three-dose series administered in a 0-, 2-, and 6-month schedule. In the phase II trials, rLP2086 elicited a robust immune response against a panel of MenB test strains. A strong immune response was evident in a marked proportion of subjects after two vaccine doses, with a further increase after a third dose. The four primary test strains used were selected to be representative of MenB strains prevalent in the USA, with each expressing an fHBP variant heterologous to the vaccine antigens. rLP2086 was generally well tolerated in the trials, with most adverse reactions being mild to moderate in severity. Although some questions remain, including the duration of the protective response, rLP2086 vaccine has the potential to be a valuable tool for the prevention of invasive MenB disease.

LpMab-12 Established by CasMab Technology Specifically Detects Sialylated O-Glycan on Thr52 of Platelet Aggregation-Stimulating Domain of Human Podoplanin.

Directory of Open Access Journals (Sweden)

Yukinari Kato

Full Text Available Podoplanin (PDPN, also known as Aggrus, possesses three tandem repeat of platelet aggregation-stimulating (PLAG domains in its N-terminus. Among the PLAG domains, sialylated O-glycan on Thr52 of PLAG3 is essential for the binding to C-type lectin-like receptor-2 (CLEC-2 and the platelet-aggregating activity of human PDPN (hPDPN. Although various anti-hPDPN monoclonal antibodies (mAbs have been generated, no specific mAb has been reported to target the epitope containing glycosylated Thr52. We recently established CasMab technology to develop mAbs against glycosylated membrane proteins. Herein, we report the development of a novel anti-glycopeptide mAb (GpMab, LpMab-12. LpMab-12 detected endogenous hPDPN by flow cytometry. Immunohistochemical analyses also showed that hPDPN-expressing lymphatic endothelial and cancer cells were clearly labeled by LpMab-12. The minimal epitope of LpMab-12 was identified as Asp49-Pro53 of hPDPN. Furthermore, LpMab-12 reacted with the synthetic glycopeptide of hPDPN, corresponding to 38-54 amino acids (hpp3854: 38-EGGVAMPGAEDDVVTPG-54, which carries α2-6 sialylated N-acetyl-D-galactosamine (GalNAc on Thr52. LpMab-12 did not recognize non-sialylated GalNAc-attached glycopeptide, indicating that sialylated GalNAc on Thr52 is necessary for the binding of LpMab-12 to hPDPN. Thus, LpMab-12 could serve as a new diagnostic tool for determining whether hPDPN possesses the sialylation on Thr52, a site-specific post-translational modification critical for the hPDPN association with CLEC-2.

76 FR 17180 - C3 Capital Partners II, L.P.; Notice Seeking Exemption Under 312 of the Small Business Investment...

Science.gov (United States)

2011-03-28

... SMALL BUSINESS ADMINISTRATION [License No. 07/07-0113] C3 Capital Partners II, L.P.; Notice Seeking Exemption Under 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that C3 Capital Partners IT, L.P., 4520 Main Street, Suite 1600, Kansas City, Missouri, 64111-7700...

77 FR 5613 - C3 Capital Partners II, L.P.; Notice Seeking Exemption Under 312 of the Small Business Investment...

Science.gov (United States)

2012-02-03

... SMALL BUSINESS ADMINISTRATION [License No. 07/07-0113] C3 Capital Partners II, L.P.; Notice Seeking Exemption Under 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given that C3 Capital Partners II, L.P., 4520 Main Street, Suite 1600, Kansas City, Missouri 64111-7700...

Serum LP(A) levels in randomized healthy men from different European countries

NARCIS (Netherlands)

Cigolini, M; Seidell, J C; Zenti, M G; Bonadonna, G; Zambelli, L; Deslypere, J P; Contaldo, F; Cruz, A.; Charzewska, J; Targher, G

Serum lipoprotein(a) [Lp(a)], blood lipids, serum insulin and anthropometric parameters were determined in randomized samples of 38-year-old men living in six European cities: Ede (The Netherlands), Deinze (Belgium), Warsaw (Poland), Lumiar (Portugal), Verona and Naples (respectively in northern and

On Some Isomorphisms between Bounded Linear Maps and Non-Commutative Lp-Spaces

Directory of Open Access Journals (Sweden)

E. J. Atto

2014-04-01

Full Text Available We define a particular space of bounded linear maps using a Von Neumann algebra and some operator spaces. By this, we prove some isomorphisms, and using interpolation in some particular cases, we get analogue of non-commutative Lp spaces.

76 FR 78958 - Bureau of Political Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Science.gov (United States)

2011-12-20

... Mexico. The United States Government is prepared to license the export of these items having taken into... certification involves the export of defense articles, including technical data, and defense services to Japan for the export and assembly of the Vertical Launch Anti-Submarine Rocket system for Japan. The United...

Comparison of Lp(a) concentrations and some potential effects in hemodialysis, CAPD, transplantation, and control groups, and review of the literature.

Science.gov (United States)

Gault, M H; Longerich, L L; Purchase, L; Harnett, J; Breckenridge, C

1995-01-01

Apolipoprotein (a)-Lp(a)-is reported to be an independent risk factor for coronary artery disease and for hemodialysis (HD) access occlusion. Homology with plasminogen may predispose to thrombosis. High concentrations usually have been reported in patients on HD and on continuous ambulatory peritoneal dialysis (CAPD), but near-normal values in many kidney transplants (TP). We used Pharmacia immunoradiometric assay in 52 patients on HD, 58 on CAPD, 94 after TP, and 56 controls. The Lp(a) mean levels for CAPD, HD, TP, and control groups were 738, 647, 348, and 368 U/l and the medians were 542, 537, 96 and 143 U/l, respectively. The means and medians for CAPD and HD were significantly greater than those for TP and controls (p fall 77%). The dominant Apo(a) isoform in 10 of 13 patients on CAPD or HD with high Lp(a) values was the equivalent of S2 (Utermann). Lp(a) in HD or CAPD is often elevated and regulated by both genetic and renal failure factors, but falls after TP with return of renal function and mainly genetic regulation. Lp(a) was not a risk factor for coronary artery disease in HD or CAPD patients and did not fall significantly with two drugs or diet.

Prospects for CW and LP operation of the European XFEL in hard X-ray regime

International Nuclear Information System (INIS)

Brinkmann, R.; Schneidmiller, E.A.; Sekutowicz, J.; Yurkov, M.V.

2014-03-01

The European XFEL will operate nominally at 17.5 GeV in SP (short pulse) mode with 0.65 ms long bunch train and 10 Hz repetition rate. A possible upgrade of the linac to CW (continuous wave) or LP (long pulse) modes with a corresponding reduction of electron beam energy is under discussion since many years. Recent successes in the dedicated R and D program allow to forecast a technical feasibility of such an upgrade in the foreseeable future. One of the challenges is to provide sub-Aangstrom FEL operation in CW and LP modes. In this paper we perform a preliminary analysis of a possible operation of the European XFEL in the hard X-ray regime in CW and LP modes with the energies of 7 GeV and 10 GeV, respectively. We consider lasing in the baseline XFEL undulator as well as in a new undulator with a reduced period. We show that, with reasonable requirements on electron beam quality, lasing on the fundamental will be possible in sub-Aangstrom regime. As an option for generation of brilliant photon beams at short wavelengths we also consider harmonic lasing that has recently attracted a significant attention.

Comparative Genomic Analysis of Lactobacillus plantarum GB-LP1 Isolated from Traditional Korean Fermented Food.

Science.gov (United States)

Yu, Jihyun; Ahn, Sojin; Kim, Kwondo; Caetano-Anolles, Kelsey; Lee, Chanho; Kang, Jungsun; Cho, Kyungjin; Yoon, Sook Hee; Kang, Dae-Kyung; Kim, Heebal

2017-08-28

As probiotics play an important role in maintaining a healthy gut flora environment through antitoxin activity and inhibition of pathogen colonization, they have been of interest to the medical research community for quite some time now. Probiotic bacteria such as Lactobacillus plantarum , which can be found in fermented food, are of particular interest given their easy accessibility. We performed whole-genome sequencing and genomic analysis on a GB-LP1 strain of L. plantarum isolated from Korean traditional fermented food; this strain is well known for its functions in immune response, suppression of pathogen growth, and antitoxin effects. The complete genome sequence of GB-LP1 is a single chromosome of 3,040,388 bp with 2,899 predicted open reading frames. Genomic analysis of GB-LP1 revealed two CRISPR regions and genes showing accelerated evolution, which may have antibiotic and antitoxin functions. The aim of the present study was to predict strain specific-genomic characteristics and assess the potential of this new strain as lactic acid bacteria at the genomic level using in silico analysis. These results provide insight into the L. plantarum species as well as confirm the possibility of its utility as a candidate probiotic.

Prospects for CW and LP operation of the European XFEL in hard X-ray regime

Energy Technology Data Exchange (ETDEWEB)

Brinkmann, R.; Schneidmiller, E.A.; Sekutowicz, J.; Yurkov, M.V.

2014-03-15

The European XFEL will operate nominally at 17.5 GeV in SP (short pulse) mode with 0.65 ms long bunch train and 10 Hz repetition rate. A possible upgrade of the linac to CW (continuous wave) or LP (long pulse) modes with a corresponding reduction of electron beam energy is under discussion since many years. Recent successes in the dedicated R and D program allow to forecast a technical feasibility of such an upgrade in the foreseeable future. One of the challenges is to provide sub-Aangstrom FEL operation in CW and LP modes. In this paper we perform a preliminary analysis of a possible operation of the European XFEL in the hard X-ray regime in CW and LP modes with the energies of 7 GeV and 10 GeV, respectively. We consider lasing in the baseline XFEL undulator as well as in a new undulator with a reduced period. We show that, with reasonable requirements on electron beam quality, lasing on the fundamental will be possible in sub-Aangstrom regime. As an option for generation of brilliant photon beams at short wavelengths we also consider harmonic lasing that has recently attracted a significant attention.

Needed: Reincarnation of National Defense Education Act of 1958

Science.gov (United States)

Harris, Mary M.; Miller, James R.

2005-01-01

This paper reviews the historical and current response of the United States to threats to its world leadership in scientific endeavors, with particular attention to the National Defense Education Act of 1958. The current status of the United States in mathematics, science, and engineering education is reviewed with respect to K-12 student…

Excessive Profits of German Defense Contractors

Science.gov (United States)

2014-09-01

its business unit Thyssen Krupp Marine Systems, is a German defense contractor. (2) Tognom AG Tognum AG owned the MTU Friedrichshafen GmbH before... Friedrichshafen provided engines for many ships of the German Navy and for German battle tanks, such as the Leopard I and Leopard II. MTU refers to the

75 FR 6200 - Equitrans, L.P.; Notice of Request Under Blanket Authorization

Science.gov (United States)

2010-02-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP10-46-000] Equitrans, L.P..., Monongalia, and Wetzel Counties, West Virginia and to make certain modifications to compressor engines at [email protected] or call toll-free, (866) 208-3676 or TTY, (202) 502-8659. Specifically, Equitrans...

76 FR 61682 - Panhandle Eastern Pipe Line Company, LP; Notice of Application

Science.gov (United States)

2011-10-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-546-000] Panhandle Eastern Pipe Line Company, LP; Notice of Application On September 16, 2011, Panhandle Eastern Pipe Line... free). For TTY, call (202) 502-8659. Comment Date: 5 p.m. Eastern Time on October 19, 2011. Dated...

United States Department of Defense: Agency Financial Report Fiscal Year 2014

Science.gov (United States)

2014-01-01

associated environmental costs using two methods: physical capacity for operating landfills and life expectancy in years for all other assets. The...construction, and rehabilitation projects on inland waterways. The BFS manages and invests for the Trust Fund. Defense Commissary Agency Surcharge

LP-THAE induced tumor cell apoptosis of rabbit VX2 liver carcinoma

International Nuclear Information System (INIS)

Chen Shengli; Quan Yi; Huang Zicheng; Chen Guodong; Zhu Dongliang

2007-01-01

Objective: To research tumor cell apoptosis induced by Lp-THAE of rabbit VX2 liver implanted tumor. Methods: 27 New Zealand white rabbits implanted with VX2 tumor at left middle lobe of the liver divided into three groups: Group A(n= 9) Lp-THAE: treated through transhepatic artery catheterization; Group B(n=9) THAI and Group C(n=9) as control. The rabbits were executed at second to fifth day after treatment. HE dye microscopy was taken for counting the typical apoptosis cells and calculating apoptosis index (ApI). FITC-AnnexinV/PI assay was used for measuring apoptosis by flow cytometry. Results: The ApI of tumor central area and marginal area were (17.769±2.417)%, (4.129±1.172)%, P<0.01. The percentages of tumor cell apoptosis and tumor cell necrosis were (16.483±1.404)%, (9.478±0.964)%, P<0.01 and (43.559±5.053)%, (33.460±1.840)%, P=0.093. The total percentages of tumor cell apoptosis and necrosis were (60.042±13.979)%, (42.938±8.979)%, P< 0.01, at tumor center and marginal area in THAE group respectively. The ApI, percentages of tumor cell apoptosis and necrosis in THAE group were significantly higher than those of THAI group (P<0.01). The percentages of tumor cell apoptosis at tumor center area in THAE group were significantly higher than those of tumor marginal area(P<0.01). Conclusion: Induced tumor cell apoptosis and necrosis are two mechanisms of action for Lp-THAE treatment of liver carcinoma. (authors)

Optimal design for crosstalk analysis in 12-core 5-LP mode homogeneous multicore fiber for different lattice structure

Science.gov (United States)

Kumar, Dablu; Ranjan, Rakesh

2018-03-01

12-Core 5-LP mode homogeneous multicore fibers have been proposed for analysis of inter-core crosstalk and dispersion, with four different lattice structures (circular, 2-ring, square lattice, and triangular lattice) having cladding diameter of 200 μm and a fixed cladding thickness of 35 μm. The core-to-core crosstalk impact has been studied numerically with respect to bending radius, core pitch, transmission distance, wavelength, and core diameter for all 5-LP modes. In anticipation of further reduction in crosstalk levels, the trench-assisted cores have been incorporated for all respective designs. Ultra-low crosstalk (-138 dB/100 km) has been achieved through the triangular lattice arrangement, with trench depth Δ2 = -1.40% for fundamental (LP01) mode. It has been noted that the impact of mode polarization on crosstalk behavior is minor, with difference in crosstalk levels between two polarized spatial modes as ≤0.2 dB. Moreover, the optimized cladding diameter has been obtained for all 5-LP modes for a target value of crosstalk of -50 dB/100 km, with all the core arrangements. The dispersion characteristic has also been analyzed with respect to wavelength, which is nearly 2.5 ps/nm km at operating wavelength 1550 nm. The relative core multiplicity factor (RCMF) for the proposed design is obtained as 64.

The Spanish Contribution to European Security and Defense

Directory of Open Access Journals (Sweden)

Félix Sanz

2000-05-01

Full Text Available The author examines Spain’s material and intellectual contributions to European security and defense. In the first place, he provides an overview of the changes in the personal qualifications of the Spanish Armed Forces and in the mentality of the military officials in adapting to the work of international organisms and to cooperation in broadlydefined schemes of security. On this point, he highlights the Spanish contribution to the missions carried out by the United Nations, OSCE and the WEU. With respect to NATO, Félix Sanz analyzes the Spanish participation before and after this country’s integrationin military structure and in the operative plans of the Alliance. Sanz also underscores the contribution made to multinational forces such as Eurocorps, Eurofor/Euromarfor, the Italian-Spanish amphibious force and, in the future, the European air group. He discussesSpain’s support for other bilateral forums for security, in particular the relation with the United States. In the area of intellectual contributions, the author underlines this country’sinterest in bringing about a convergence of defense forces, Spain’s support for a multinational military and its willingness to collaborate in the design of European defense.

Server scheduling in the Lp norm: A rising tide lifts all boat

NARCIS (Netherlands)

Bansal, N.; Pruhs, K.R.

2003-01-01

Often server systems do not implement the best known algorithms for optimizing average Quality of Service (QoS) out of concern of that these algorithms may be insufficiently fair to individual jobs. The standard method for balancing average QoS and fairness is optimize the Lp metric, 1

Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man

Directory of Open Access Journals (Sweden)

Edvinsson Lars

2009-03-01

Full Text Available Abstract Background Clinical observations have revealed that patients throw up undigested paracetamol tablets several hours following intake of rosehip drink with Lp299v (Proviva. The purpose of this study was to demonstrate if this translates into altered plasma levels of paracetamol in nineteen healthy subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol. Findings The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 μmol/l was reached (a 95% confidence interval of 57,161. The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 μmol/l (95% confidence intervals contain only zero for both rosehip treatments. There were significant differences in AUC, maximal paracetamol concentration and in time to maximal paracetamol concentration. The median maximal paracetamol concentration was 147 μmol/l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 μmol/l, and than the median for rosehip-drink without Lp299v, 106.5 μmol/l (p = 0.002, and p = 0.003; there were no significant difference between rosehip drink with or without Lp299v (p > 0.3. Conclusion We have demonstrated an interaction between the uptake of paracetamol and the solvent in rosehip drink/Provia which mainly consists of long chain carbohydrates. This may in the clinic translate to the use of more drug than it is necessary.

Study on combat effectiveness of air defense missile weapon system based on queuing theory

Science.gov (United States)

Zhao, Z. Q.; Hao, J. X.; Li, L. J.

2017-01-01

Queuing Theory is a method to analyze the combat effectiveness of air defense missile weapon system. The model of service probability based on the queuing theory was constructed, and applied to analyzing the combat effectiveness of "Sidewinder" and "Tor-M1" air defense missile weapon system. Finally aimed at different targets densities, the combat effectiveness of different combat units of two types' defense missile weapon system is calculated. This method can be used to analyze the usefulness of air defense missile weapon system.

Ballistic Missile Defense in the European Theater: Political, Military and Technical Considerations

National Research Council Canada - National Science Library

Terstegge, Stephen D

2007-01-01

... that threatens the homeland of the United States. Therefore, the United States faces the complex security challenge of emplacing ballistic missile defense assets on European soil in the very near-term to mitigate this threat...

Defense Business Board

Science.gov (United States)

Skip to main content (Press Enter). Toggle navigation Defense Business Board Search Search Defense Business Board: Search Search Defense Business Board: Search Defense Business Board Business Excellence in Defense of the Nation Defense Business Board Home Charter Members Meetings Studies Contact Us The Defense

Department of Defense Dictionary of Military and Associated Terms

National Research Council Canada - National Science Library

2005-01-01

The Department of Defense Dictionary of Military and Associated Terms set forth standard US military and associated terminology to encompass the joint activity of the Armed Forces of the United States...

Latvian Security and Defense Policy within the Twenty-First Century Security Environment

Directory of Open Access Journals (Sweden)

Rublovskis Raimonds

2014-12-01

Full Text Available The aim of this paper is to analyze fundamental factors which form and profoundly shape security and defense policy of the Republic of Latvia. One can argue that historical background, geographical location, common institutional history within the former Soviet Union, the Russia factor, the relative smallness of the territory of state and the population, the ethnic composition of the population, the low density of the population and rather limited financial and manpower resources available for the defense of the Republic of Latvia are the key factors of influence on the state security and defense policy. The core principles of the security and defense policy of Latvia are the membership in powerful global military alliance of NATO and bilateral strategic partnership with the United States. However, security and defense cooperation among the three Baltic States as well as enhanced cooperation within the Baltic-Nordic framework is seen as an important supplementary factor for the increased security of the Republic of Latvia. Latvia has developed a sustainable legal and institutional framework in order to contribute to state security and defense; however, security challenges and significant changes within the global security environment of the twenty-first century will further challenge the ability of the Republic of Latvia to sustain its current legal framework, and more importantly, current institutional structure of Latvian security and defense architecture. Significant internal and external challenges will impact the fundamental pillars of Latvian security and defense policy, such as American strategic shift to the Pacific, and lack of political will to increase defense budgets in European part of NATO. It has to be clear that very independence, security and defense of the Republic of Latvia depend on the ability of NATO to remain an effective organization with timely and efficient decision-making, and the ability of the United States to remain

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 2. Nuclear Weapons Effects and Shelter.

Science.gov (United States)

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

Basic information about nuclear weapons is presented so that their effects can be meaningfully related to the defensive countermeasures which will be most effective against them. Major topics include: (1) Explosive power of nuclear weapons, (2) Major effects of nuclear explosions, (3) Two basic types of nuclear explosions, (4) Contrast between air…

77 FR 13013 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Science.gov (United States)

2012-03-05

... Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the United States... 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System...

76 FR 14387 - Texas Eastern Transmission, LP; Notice of Request Under Blanket Authorization

Science.gov (United States)

2011-03-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-118-000] Texas Eastern... Eastern Transmission, LP (Texas Eastern), Post Office Box 1642, Houston, Texas 77251-1642, filed in Docket... West Cameron Blocks 566, 565, and 548, offshore Louisiana, under Texas Eastern's blanket certificate...

76 FR 21787 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Science.gov (United States)

2011-04-18

...-export of major defense equipment valued (in terms of its original acquisition cost) at $25,000,000 or... defense articles, including technical data, and defense services in the amount of $50,000,000 or more. The... Pods for the Commonwealth of Australia. The United States Government is prepared to license the export...

By Land or By Sea: An Analysis of National Missile Defense Options

National Research Council Canada - National Science Library

Altman, Bern J

2000-01-01

In conformance with the National Missile Defense (NMD) Act of 1999, the United States is pursuing the path to fielding a system capable of providing protection for all of the United States against a limited ballistic missile attack...

76 FR 57087 - Stone Harbor Investment Partners LP, et al.; Notice of Application

Science.gov (United States)

2011-09-15

... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 29784; File No. 812-13931] Stone Harbor Investment Partners LP, et al.; Notice of Application September 7, 2011. AGENCY: Securities..., or cause more than 10% of the acquired company's voting stock to be owned by investment companies and...

76 FR 65507 - Notice of Petition for Rate Approval; Eagle Ford Midstream, LP

Science.gov (United States)

2011-10-21

... Petition for Rate Approval; Eagle Ford Midstream, LP Take notice that on October 11, 2011, (Eagle Ford..., and its initial baseline Statement of Operating Conditions. Eagle Ford states that it is an existing..., currently providing intrastate services to its customers. Eagle Ford proposed rates for Section 311...

The Role of the Army Reserve in the Weapons of Mass Destruction/Homeland Defense Program

National Research Council Canada - National Science Library

Smith, Joseph

2000-01-01

... attack. Given these increasing threats to the territory, population, and infrastructure of the United States, the Army Reserve should have an expanded role in providing homeland defense capabilities. The Army Reserve is well suited to homeland defense missions.

Evaluation of Protective Immune Responses Induced by Recombinant TrxLp and ENO2 Proteins against Toxoplasma gondii Infection in BALB/c Mice

Directory of Open Access Journals (Sweden)

Meng Wang

2016-01-01

Full Text Available Toxoplasma gondii is an obligate intracellular parasitic protozoan that can infect almost all species of warm-blooded animals. As any chemical-based drugs could not act against the tissue cyst stage of T. gondii, vaccination may be one of the ideal control strategies. In the present study, two new vaccine candidates, named TgENO2 and TgTrxLp, were purified from Escherichia coli with pET-30a(+ expression system and then were injected into BALB/c mice to evaluate the protective efficacy against acute and chronic toxoplasmosis. The results showed that both the recombinant proteins, either alone or in combination, could elicit strong humoral and cellular immune responses with a higher level of IgG antibodies, IFN-γ, IL-2, CD4+, and CD8+ T cells as compared to those in mice from control groups. After acute challenge with tachyzoites of the GJS strain, mice immunized with rTgTrxLp (8±2.77 d, rTgENO2 (7.4±1.81 d, and rTgTrxLp + rTgENO2 (8.38±4.57 d proteins showed significantly longer survival time than those that received Freund’s adjuvant (6.78±2.08 d and PBS (6.38±4.65 d (χ2 = 9.687, df = 4, P=0.046. The protective immunity of rTgTrxLp, rTgENO2, and rTgTrxLp + rTgENO2 proteins against chronic T. gondii infection showed 69.77%, 58.14%, and 20.93% brain cyst reduction as compared to mice that received PBS. The present study suggested that both TgENO2 and TgTrxLp were potential candidates for the development of multicomponent vaccines against toxoplasmosis.

Defense of a space elevator

Energy Technology Data Exchange (ETDEWEB)

Laubscher, B. E. (Bryan E.)

2004-01-01

The Space Elevator (SE) represents a major paradigm shift in space access. If the SE's promise of low-cost access is to be realized, everything becomes economically more feasible to accomplish in space. In this paper we describe a defensive system of the SE. The primary scenario adopted for this analysis is the SE based on a floating platform in the ocean along the equator. A second possible scenario is the SE stationed on land (island or continent) on or near the equator. The SE will capture the imaginations of people around the world. It will become a symbol of power, capability, wealth and prestige for the country that builds it. As such, it will become a prime terrorist target. Moreover, the tremendous economic leverage afforded by the SE might motivate rogue nations to plot its destruction. Therefore, it is necessary to consider the requirements for defense of the SE. For the purposes of this paper it is assumed that the SE is to be deployed by the United States or one of its companies, and the resources of the US are available for its defense.

The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei

Directory of Open Access Journals (Sweden)

Tisch Doris

2011-12-01

Full Text Available Abstract Background In the biotechnological workhorse Trichoderma reesei (Hypocrea jecorina transcription of cellulase genes as well as efficiency of the secreted cellulase mixture are modulated by light. Components of the heterotrimeric G-protein pathway interact with light-dependent signals, rendering this pathway a key regulator of cellulase gene expression. Results As regulators of heterotrimeric G-protein signaling, class I phosducin-like proteins, are assumed to act as co-chaperones for G-protein beta-gamma folding and exert their function in response to light in higher eukaryotes. Our results revealed light responsive transcription of the T. reesei class I phosducin-like protein gene phlp1 and indicate a light dependent function of PhLP1 also in fungi. We showed the functions of PhLP1, GNB1 and GNG1 in the same pathway, with one major output being the regulation of transcription of glycoside hydrolase genes including cellulase genes in T. reesei. We found no direct correlation between the growth rate and global regulation of glycoside hydrolases, which suggests that regulation of growth does not occur only at the level of substrate degradation efficiency. Additionally, PhLP1, GNB1 and GNG1 are all important for proper regulation of light responsiveness during long term exposure. In their absence, the amount of light regulated genes increased from 2.7% in wild type to 14% in Δphlp1. Besides from the regulation of degradative enzymes, PhLP1 was also found to impact on the transcription of genes involved in sexual development, which was in accordance with decreased efficiency of fruiting body formation in Δphlp1. The lack of GNB1 drastically diminished ascospore discharge in T. reesei. Conclusions The heterotrimeric G-protein pathway is crucial for the interconnection of nutrient signaling and light response of T. reesei, with the class I phosducin-like protein PhLP1, GNB1 and GNG1 acting as important nodes, which influence light

75 FR 57844 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2010-09-23

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Previously Held by Israel Aircraft Industries, Ltd.): Amendment 39-16438. Docket No. FAA-2010-0555... (Type Certificate previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200...

76 FR 65717 - Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment

Science.gov (United States)

2011-10-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2713-082-New York] Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and the Federal Energy Regulatory Commission's (Commission...

Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis

DEFF Research Database (Denmark)

Costa, D J; Marteau, P; Amouyal, M

2014-01-01

BACKGROUND/OBJECTIVES: An imbalance between Th1 and Th2 cells is involved in allergic rhinitis (AR) that may be improved by probiotics. To test the efficacy of the probiotic Lactobacillus paracasei subsp. paracasei LP-33, a double-blind, placebo-controlled, randomized trial was carried out in pat...

76 FR 25330 - Texas Eastern Transmission, LP; Notice of Request Under Blanket Authorization

Science.gov (United States)

2011-05-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP11-216-000] Texas Eastern... Eastern Transmission, LP (Texas Eastern), 5400 Westheimer Court, Houston, Texas 77056, filed in Docket No... in the termination of any services to Texas Eastern's customers, all as more fully set forth in the...

Soviet debate on missile defense

Energy Technology Data Exchange (ETDEWEB)

Parrott, B.

1987-04-01

Although the Strategic Defense Initiative (SDI) is meant to cope with the danger of a Soviet nuclear attack, the recent US debate over SDI has paid surprisingly little attention to Soviet views of ballistic missile defense. Despite the existence of a substantial body of pertinent scholarship, the debate has failed to take adequate account of major changes in Soviet ballistic missile defense policy since the mid-1960s. It has also neglected the links between current Soviet military policy and broader Soviet political and economic choices. The Soviets regard SDI not as a novel undertaking to reduce the risks of nuclear war but as an extension of the geopolitical competition between the superpowers. This competition has been dominated in the 1980s, in the Soviet view, by sharply increased US assertiveness and the decline of detente. Viewing SDI as a manifestation of these general trends, Soviet decision makers find the prospect of an unregulated race in ballistic missile defenses and military space technologies deeply unsettling. The deterioration of superpower relations has raised serious doubts in Moscow about the wisdom of Soviet external policy during the 1970s and has provoked sharp internal differences over policy toward the US. Already highly suspicious of the Reagan administration, the elite is united by a general conviction that SDI is an American gambit that may ultimately undercut past Soviet strategic gains and pose a grave new threat to Soviet security. 14 references.

Defense Logistics: Department of Defense's Annual Report on the Status of Prepositioned Materiel and Equipment Can Be Enhanced to Better Inform Congress

National Research Council Canada - National Science Library

Solis, William M

2008-01-01

The Department of Defense (DOD) prepositions equipment at strategic locations around the world in order to field combat-ready forces in days, rather than the weeks it would take if equipment had to be moved from the United States...

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 4. Warning, Emergency Operations, and Support Programs.

Science.gov (United States)

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

The need for, and a description of, emergency functions required to save lives and protect property in nuclear or natural disasters are presented. Topics discussed include: (1) The Civil Defense Warning System, (2) Introduction to the Emergency Operations Program, (3) Five subprograms of the Emergency Operations Program, (4) Emergency Operations…

76 FR 46287 - Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment

Science.gov (United States)

2011-08-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2047-049] Erie Boulevard Hydropower, L.P.; Notice of Availability of Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and the Federal Energy Regulatory Commission's (Commission or FERC) regulations...

A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants.

Science.gov (United States)

Martinon-Torres, Federico; Gimenez-Sanchez, Francisco; Bernaola-Iturbe, Enrique; Diez-Domingo, Javier; Jiang, Qin; Perez, John L

2014-09-08

Neisseria meningitidis serogroup B (MnB) is a major cause of invasive meningococcal disease in infants. A conserved, surface-exposed lipoprotein, LP2086 (a factor H-binding protein [fHBP]), is a promising MnB vaccine target. A bivalent, recombinant vaccine targeting the fHBP (rLP2086) of MnB was developed. This phase 1/2 clinical study was designed to assess the immunogenicity, safety, and tolerability of a 4-dose series of the rLP2086 vaccine at 20-, 60-, 120-, or 200-μg dose levels in vaccine-naive infants when given with routine childhood vaccines. The study was to consist of two phases: a single-blind sentinel phase and an open-label full enrollment phase. During the sentinel phase, randomization of subjects to the next higher dose was delayed pending a 14-day safety review of dose 1 of the preceding dose cohort. The full enrollment phase was to occur after completion of the sentinel phase. Local reactions were generally mild and adverse events infrequent; however, after only 46 infants were randomized into the study, fever rates were 64% and 90% in subjects receiving one 20- or 60-μg rLP2086 dose, respectively. Most fevers were group and 1 subject in the 60-μg group experienced fevers >39.0°C; no fevers were >40.0°C. Due to these high fever rates, the study was terminated early. No immunogenicity data were collected. This report discusses the safety and acceptability of rLP2086 in infants after one 20- or 60-μg dose. Due to the high fever rate experienced in the 20- and 60-μg groups, rLP2086 in the current formulation may not be acceptable for infants. Copyright © 2014. Published by Elsevier Ltd.

77 FR 58323 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2012-09-20

... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150 airplanes. This proposed AD was.... Discussion The Civil Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has...

77 FR 32069 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2012-05-31

... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... previously held by Israel Aircraft Industries, Ltd.) Model Galaxy and Gulfstream 200 airplanes. This proposed... receive about this proposed AD. Discussion The Civil Aviation Authority of Israel (CAAI), which is the...

Strain and temperature characteristics of the LP11 mode based on a few-mode fiber Bragg grating and core-offset splicing

Science.gov (United States)

Jin, Wenxing; Xu, Yao; Jiang, Youchao; Wu, Yue; Yao, Shuzhi; Xiao, Shiying; Qi, Yanhui; Ren, Wenhua; Jian, Shuisheng

2018-02-01

We propose and demonstrate a ring fiber laser based on a few-mode fiber Bragg grating for strain and temperature sensing using only the LP11 mode. The core-offset splicing method is used to ensure effective coupling from the fundamental mode to the LP11 mode. A stable erbium-doped fiber laser operating as a single LP11 mode with a 3 dB linewidth of about 0.02 nm and an optical signal-to-noise ratio over 42 dB is achieved by appropriately adjusting the polarization controller between the optical circulator and the few-mode fiber Bragg grating. A high axial strain sensitivity of 0.8778 pm μ\\varepsilon-1 and a temperature sensitivity of 9.9214 pm °C-1 are achieved with the advantages of all-fiber, simple construction and easy control.

Safety and immunogenicity of a meningococcal B bivalent rLP2086 vaccine in healthy toddlers aged 18-36 months: a phase 1 randomized-controlled clinical trial.

Science.gov (United States)

Marshall, Helen S; Richmond, Peter C; Nissen, Michael D; Jiang, Qin; Anderson, Annaliesa S; Jansen, Kathrin U; Reynolds, Graham; Ziegler, John B; Harris, Shannon L; Jones, Thomas R; Perez, John L

2012-10-01

A bivalent, recombinant, factor H-binding protein (rLP2086) vaccine was developed to protect against invasive Neisseria meningitidis serogroup B (MnB) in children and adolescents. Healthy toddlers (N = 99) were enrolled to 3 ascending dose-level cohorts (20, 60 or 200 μg). Within each cohort (n = 33), subjects were randomized to receive an initial formulation of the bivalent rLP2086 vaccine at 0, 1 and 6 months or hepatitis A vaccine/placebo control (2:1 ratio). Reactogenicity was assessed by parental reporting of local and systemic reactions using electronic diaries and reports of unsolicited adverse events. Immunogenicity was assessed by serum bactericidal activity assay using human complement and rLP2086-specific IgG binding. The vaccine was considered to be well tolerated. Tenderness was the most frequently reported local reaction. Upper respiratory tract infection was the most commonly reported adverse event and occurred more frequently in the control group. Three cases (200 μg dose) of severe erythema that did not interfere with limb movement were reported. Four toddlers developed fever >40.0°C, 3 in the 200 μg group and 1 in the 60 μg group. Postdose 3, seroconversion (serum bactericidal activity assay using human complement ≥4-fold rise from baseline) was observed in 61.1-88.9% of participants against MnB strains expressing LP2086 variants homologous or nearly homologous to vaccine antigens and 11.1-44.4% against MnB strains expressing heterologous LP2086 variants. Seroconversion was observed in 77.8-100% of participants against additional, exploratory MnB strains expressing vaccine-homologous or heterologous LP2086 variants. This study shows that the bivalent rLP2086 vaccine is well tolerated and immunogenic in toddlers.

Assessment of Ukranian National Defense Policy

Science.gov (United States)

2012-03-09

Romanian- Slovakian-Hungarian engineer battalion “Tisa”, as a rapid reaction force with the mission of natural disaster relief in the Carpathian region...threats (Army’s multifunctional NBC protection and engineer units) and experience of their using ( Chernobyl nuclear plant in 1986, humanitarian...man-made disasters was exemplified by the 2011 nuclear catastrophe in Japan. Moreover, based on the results of the Strategic Defense Review in Ukraine

76 FR 41432 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2011-07-14

... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model Galaxy, Gulfstream... proposed AD. Discussion The Civil Aviation Authority (CAA), which is the aviation authority for Israel, has... Held by Israel Aircraft Industries, Ltd.): Docket No. FAA-2011-0716; Directorate Identifier 2011-NM-013...

75 FR 36296 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Science.gov (United States)

2010-06-25

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... contact we receive about this proposed AD. Discussion The Civil Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli Airworthiness Directive 01-10-01-07R1, dated...

The Effects of Curcuma longa L., Purple Sweet Potato, and Mixtures of the Two on Immunomodulation in C57BL/6J Mice Infected with LP-BM5 Murine Leukemia Retrovirus.

Science.gov (United States)

Park, Soo-Jeung; Lee, Dasom; Lee, Minhee; Kwon, Han-Ol; Kim, Hyesook; Park, Jeongjin; Jeon, Woojin; Cha, Minseok; Jun, Suhwa; Park, Kwangjin; Lee, Jeongmin

2018-06-04

The immune response is stimulated to protect the body from external antigens and is controlled by several types of immune cells. In the present study, the immunomodulatory effects of Curcuma longa L., purple sweet potato, and mixtures of the two (CPM) were investigated in C57BL/6 mice infected with LP-BM5 murine leukemia virus (MuLV). Mice were divided into seven groups as follows: normal control, infected control (LP-BM5 MuLV infection), positive control (LP-BM5 MuLV infection+dietary supplement of red ginseng 300 mg/kg body weight), the original powder of C. longa L. (C; LP-BM5 MuLV infection+dietary supplement of C 189 mg/kg body weight), the original powder of purple sweet potato (P; LP-BM5 MuLV infection+dietary supplement of P 1811 mg/kg body weight), CPM Low (CPL; LP-BM5 MuLV infection+CPM 2 g/kg body weight), and CPM High (CPH; LP-BM5 MuLV infection+CPM 5 g/kg body weight). Dietary supplementation lasted for 12 weeks. Dietary supplementation of CPM inhibited LP-BM5 MuLV-induced lymphadenopathy and splenomegaly and inhibited reduction of messenger RNA (mRNA) expression of major histocompatibility complex (MHC) I and II. Moreover, CPM reduced the decrease in T- and B cell proliferation, reduced the population of CD4(+)/CD8(+) T cells, and remedied the unbalanced production of T helper-1 (Th1)/T helper-2 (Th2) cytokines in LP-BM5 MuLV-infected mice. In addition, CPM inhibited reduction of phagocytosis in peritoneal macrophages and decreased serum levels of immunoglobulin A (IgA), immunoglobulin E (IgE), and immunoglobulin G (IgG). These results suggest that CPM had a positive effect on immunomodulation in C57BL/6 mice induced by LP-BM5 leukemia retrovirus infection.

Increased hepatic cholesterol esterification with essential fatty acid deficiency (EFAD): relationship to plasma lipoprotein (LP) cholesterol content

International Nuclear Information System (INIS)

Ney, D.M.; Ziboh, V.A.; Schneeman, B.O.

1986-01-01

EFAD in the rat is associated with hepatic accumulation of esterified cholesterol and altered distribution of cholesterol between plasma and hepatic tissue. Little is known regarding the impact of EFAD on LP composition. To determine the relationship between hepatic cholesterol esterification and plasma lP composition in control (C) and EFAD male Wistar rats, the authors induced EFAD with continuous intragastric (IG) infusion of EFA-free solutions containing 3.5% of calories as triolein for 7 and 14 days. C animals received IG infusion of solutions containing 3.5% of calories as linoleic acid. Data in the EFAD groups reveal: (i) marked decreases in hepatic EFAs and increases in monoenoic acids; (ii) progressive increases in hepatic content of triglyceride and esterified cholesterol with 7 and 14 days of feeding; (iii) assay of acyl CoA:cholesterol acyltransferase activity in hepatic tissue using 14 C-cholesterol demonstrates an increase in hepatic cholesterol esterification when compared to C animals. Increased hepatic cholesterol esterification correlates with elevated levels of esterified cholesterol in plasma VLDL and HDL particles. These data indicate that the elevated levels of cholesterol esters in LP particles is due, at least in part, to increased hepatic cholesterol esterification with EFAD

76 FR 70438 - Enterprise Intrastate L.P., Enterprise Texas Pipeline LLC; Notice of Filing

Science.gov (United States)

2011-11-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-4-000; Docket No. PR12-5-000; Not Consolidated] Enterprise Intrastate L.P., Enterprise Texas Pipeline LLC; Notice of Filing Take notice that on November 1, 2011, the applicants listed above filed a revised Statement of...

GENDER ISSUES: Perceptions of Readiness in Selected Units

National Research Council Canada - National Science Library

1999-01-01

.... More than 13,000 women have joined these units.3 Among the units that have opened to women are Army smoke and chemical companies, forward support battalions, air defense artillery headquarters' units, military police units, and engineer companies...

Remarks on the Phragmen-Lindelof theorem for Lp-viscosity solutions of fully nonlinear PDEs with unbounded ingredients

Directory of Open Access Journals (Sweden)

Kazushige Nakagawa

2009-11-01

Full Text Available The Phragmen-Lindelof theorem for Lp-viscosity solutions of fully nonlinear second order elliptic partial differential equations with unbounded coefficients and inhomogeneous terms is established.

Enhanced Defense Cooperation Agreement: Aquino III’s Balancing Strategy With The United States Against China

Science.gov (United States)

2017-03-01

fallen over the decades. These variations were contingent upon the nature of the Philippines’ need to balance against a perceived contemporary threat...71 In April 2014, U.S. Ambassador to the Philippines Philip Goldberg and Philippine Defense Secretary Voltaire Gazmin signed the EDCA, with...visit, Philippine Defense Secretary Voltaire Gazmin and U.S. Ambassador Philip Goldberg signed the EDCA, which was

47 CFR 74.1204 - Protection of FM broadcast, FM Translator and LP100 stations.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Protection of FM broadcast, FM Translator and... SERVICES FM Broadcast Translator Stations and FM Broadcast Booster Stations § 74.1204 Protection of FM broadcast, FM Translator and LP100 stations. (a) An application for an FM translator station will not be...

Dynamic defense workshop :

Energy Technology Data Exchange (ETDEWEB)

Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.; Helinski, Ryan; Lamb, Christopher C.

2013-02-01

On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-art work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.

Sensitivity analysis for CORSOR models simulating fission product release in LOFT-LP-FP-2 severe accident experiment

Energy Technology Data Exchange (ETDEWEB)

Hoseyni, Seyed Mohsen [Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Dept. of Basic Sciences; Islamic Azad Univ., Tehran (Iran, Islamic Republic of). Young Researchers and Elite Club; Pourgol-Mohammad, Mohammad [Sahand Univ. of Technology, Tabriz (Iran, Islamic Republic of). Dept. of Mechanical Engineering; Yousefpour, Faramarz [Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

2017-03-15

This paper deals with simulation, sensitivity and uncertainty analysis of LP-FP-2 experiment of LOFT test facility. The test facility simulates the major components and system response of a pressurized water reactor during a LOCA. MELCOR code is used for predicting the fission product release from the core fuel elements in LOFT LP-FP-2 experiment. Moreover, sensitivity and uncertainty analysis is performed for different CORSOR models simulating release of fission products in severe accident calculations for nuclear power plants. The calculated values for the fission product release are compared under different modeling options to the experimental data available from the experiment. In conclusion, the performance of 8 CORSOR modeling options is assessed for available modeling alternatives in the code structure.

Statutory Restrictions on the Position of Secretary of Defense: Issues for Congress

Science.gov (United States)

2017-01-05

Military Policy, Post-War Military Policy, H. Rept. 1765, 78th Congress, 2nd Session. 25 Roger R. Trask and Alfred Goldberg , The Department of Defense 1947...Although the United States has utilized a variation of Truman’s proposed system of military governance for the past 60 years, there was, at the time...Feickert, CRS Specialist in Military Ground Forces. 33 Roger R. Trask and Alfred Goldberg , The Department of Defense 1947-1997: Organization and

The superpower, the bridge-builder and the hesitant ally : how defense transformation divided NATO (1991-2008)

NARCIS (Netherlands)

Korteweg, Arie Rem

2011-01-01

What shaped the defense transformation policies of NATO member-states? And what does it mean for the future of the alliance? This dissertation explores the impact of the strategic cultures of the United States, the Netherlands and Germany on their efforts to adapt their defense policies and armed

Quality Control and Dosimetry in Mammographic Units in Greece

Energy Technology Data Exchange (ETDEWEB)

Flioni-Vysa, A; Xenofos, S; Stamatelatos, E; Georgolopoulou, P [Department of Medical Physics, Saint Savvas Hospital, 171 Alexandras Avenue, Athens 115 22, (Greece)

1994-12-31

Quality control measurements have been carried out on 29 mammographic units. It was found that a large percentage of users obtained Optical Densities outside the recommended values. Resolution under routine conditions was below the limit of 14 lp/mm in about 50% of the units. The skin entrance dose was in a few cases in excess of 10 micro Gray, but the mean value was well below this upper limit. Analysis of the results obtained has indicated that proper calibration of kilo voltage panel indications and automatic exposure control systems is of outmost importance and should be performed regularly. (authors). 11 refs, 2 figs 3 tabs.

Organizational structure and operation of defense/aerospace information centers in the United States of America

Science.gov (United States)

Sauter, H. E.; Lushina, L. N.

1983-01-01

U.S. Government aerospace and defense information centers are addressed. DTIC and NASA are described in terms of their history, operational authority, information services provided, user community, sources of information collected, efforts under way to improve services, and external agreements regarding the exchange of documents and/or data bases. Contents show how DTIC and NASA provide aerospace/defense information services in support of U.S. research and development efforts. In a general introduction, the importance of scientific and technical information and the need for information centers to acquire, handle, and disseminate it are stressed.

Estimated Impacts of Sequestration-Level Funding: United States Department of Defense Fiscal Year 1015 Budget Request

Science.gov (United States)

2014-04-01

Prepositioned Stocks, and Environmental Restoration. The other O&M portfolio indirectly supports Service readiness by funding such areas as training and...and administration. The portfolio also supports intelligence programs and defense-wide activities, such as the Defense Health Program, Special...2.0) (1.6) (1.1) (0.9) (5.7) SUMMARY OF MILCON Under BCA levels, the MILCON accounts would decline to allow for the rebalancing of resources

77 FR 66651 - Salient Advisors, L.P. and MarketShares ETF Trust; Notice of Application

Science.gov (United States)

2012-11-06

... Advisors, L.P. and MarketShares ETF Trust; Notice of Application October 31, 2012 AGENCY: Securities and... ETF Trust (the ``Trust''). Summary of Application: Applicants request an order that permits: (a... statutory trust. The Trust will initially offer one series, the Salient MLP and Energy Infrastructure ETF...

75 FR 65467 - Enterprise Alabama Intrastate, LLC; Enterprise Intrastate L.P; Notice of Baseline Filings

Science.gov (United States)

2010-10-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-4-000; Docket No. PR11-5-000; Not Consolidated] Enterprise Alabama Intrastate, LLC; Enterprise Intrastate L.P; Notice of Baseline Filings October 18, 2010. Take notice that on October 15, 2010, the applicants listed above...

Implementing and analyzing the multi-threaded LP-inference

Science.gov (United States)

Bolotova, S. Yu; Trofimenko, E. V.; Leschinskaya, M. V.

2018-03-01

The logical production equations provide new possibilities for the backward inference optimization in intelligent production-type systems. The strategy of a relevant backward inference is aimed at minimization of a number of queries to external information source (either to a database or an interactive user). The idea of the method is based on the computing of initial preimages set and searching for the true preimage. The execution of each stage can be organized independently and in parallel and the actual work at a given stage can also be distributed between parallel computers. This paper is devoted to the parallel algorithms of the relevant inference based on the advanced scheme of the parallel computations “pipeline” which allows to increase the degree of parallelism. The author also provides some details of the LP-structures implementation.

[Study of defense styles, defenses and coping strategies in alcohol-dependent population].

Science.gov (United States)

Ribadier, A; Varescon, I

2017-05-01

Defense mechanisms have been seen to greatly change over time and across different definitions made by different theoretical currents. Recently with the definition provided by the DSM IV, defense mechanisms have integrated the concept of coping as a defensive factor. These mechanisms are no longer considered just through a psychodynamic approach but also through a cognitive and behavioral one. In recent years, new theories have therefore integrated these two components of the defensive operation. According to Chabrol and Callahan (2013), defense mechanisms precede coping strategies. In individuals with psychopathological disorders, these authors indicate a relative stability of these mechanisms. Also, we asked about the presence of unique characteristics among people with alcohol dependence. Indeed, studies conducted with people with alcohol dependence highlight the presence of a neurotic defense style and some highly immature defenses (projection, acting out, splitting and somatization). In terms of coping strategies, persons with alcohol dependence preferentially use avoidant strategies and strategies focused on emotion. However, although several studies have been conducted to assess coping strategies and defense styles within a population of individuals with an alcohol problem, at the present time none of them has taken into account all these aspects of defense mechanisms. The aim of this study is therefore to study the defenses and defense styles and coping strategies in an alcohol-dependent population. This multicenter study (3 CHU, 1 center of supportive care and prevention in addiction and 1 clinic) received a favorable opinion of an Institutional Review Board (IRB Registration #: 00001072). Eighty alcohol-dependent individuals responded to a questionnaire assessing sociodemographic characteristics and elements related to the course of consumption. Coping strategies were assessed by means of a questionnaire validated in French: the Brief Cope. The Defense

The lipid- and lipoprotein- [LDL-Lp(a)] apheresis techniques. Updating.

Science.gov (United States)

Stefanutti, C; Morozzi, C; Perrone, G; Di Giacomo, S; Vivenzio, A; D'Alessandri, G

2012-01-01

Therapeutic plasmapheresis allows the extracorporeal removal of plasmatic lipoproteins (Lipid-apheresis) (LA). It can be non selective (non specific), semi - selective or selective low density lipoprotein-lipoprotein(a) (specific [LDL- Lp(a)] apheresis) (Lipoprotein apheresis, LDLa). The LDL removal rate is a perfect parameter to assess the system efficiency. Plasma-Exchange (PEX) cannot be considered either specific nor, selective. In PEX the whole blood is separated into plasma and its corpuscular components usually through centrifugation or rather filtration. The corpuscular components mixed with albumin solution plus saline (NaCl 0.9%) solution at 20%-25%, are then reinfused to the patient, to substitute the plasma formerly removed. PEX eliminates atherogenic lipoproteins, but also other essential plasma proteins, such as albumin, immunoglobulins, and hemocoagulatory mediators. Cascade filtration (CF) is a method based on plasma separation and removal of plasma proteins through double filtration. During the CF two hollow-fiber filters with pores of different diameter are used to eliminate the plasma components of different weight and molecular diameter. A CF system uses a first polypropylene filter with 0.55 µm diameter pores and a second one of diacetate of cellulose with 0.02 µm pores. The first filter separates the whole blood, and the plasma is then perfused through a second filter which allows the recovery of molecules with a diameter lower than 0.02 µm, and the removal of molecules larger in diameter as apoB100-containing lipoproteins. Since both albumin and immunoglobulins are not removed, or to a negligible extent, plasma-expanders, substitution fluids, and in particular albumin, as occurs in PEX are not needed. CF however, is characterized by lower selectivity since removes also high density lipoprotein (HDL) particles which have an antiatherogenic activity. In the 80's, a variation of Lipid-apheresis has been developed which allows the LDL

Accident sequences evaluation using SFATs for low power and shutdown operation of pressurized heavy water reactors

International Nuclear Information System (INIS)

Kim, Chansoo; Chung, Chang-Hyun; Yang, Huichang

2004-01-01

To maintain the level of defense-in-depth safety of Pressurized Heavy Water Reactor (PHWR) during LP/SD operation, the qualitative risk evaluation methods such as Safety Function Assessment Trees (SFATs) are required. Therefore SFATs are suggested to assess and manage the PHWR safety in LP/SD. Before this study, safety functions of PHWR were classified into 7 groups; Reactivity Control, Core Cooling, Secondary Heat Removal, Primary Heat Transport Inventory, Essential Electrical Power, Cooling Water, and Containment Integrity. The SFATs for PHWR LP/SD operations were developed along with the Plant Outage Status (POS) variation, and totally 38 SFATs were developed for Wolsung Unit 2. For the verification of SFATs logics developed, top 5 accident sequences those contribute the CDF of PHWR were selected, and plant safety status were evaluated for those accident sequences. Accident sequences such as DCC-4 (Dual Control Computer Failure), CL4-16 (Total Loss of Class IV Power), and FWPV-11 (Loss of Feedwater Supply to SG due to Failure of Pumps/Values) were included. In this research the evaluation of plant safety status by accident sequences using SFATs and the verification of the SFATs were performed. Through the verification of SFAT logics, the enhancements to the internal logics of the SFATs were made, and the dependencies between safety systems and support systems were considered. It is expected the defense-in-depth evaluation model of PHW just as SFATs can be utilized in the configuration risk management program (CRMP) development and improve technical specifications development for Korean PHWRs. (author)

22 CFR 46.3 - Aliens whose departure is deemed prejudicial to the interests of the United States.

Science.gov (United States)

2010-04-01

... United States or the United Nations for the defense of any other country. (c) Any alien who seeks to... Forces of the United States and who fails to present a Registration Certificate (SSS Form No. 2) showing... defensive operations of the United States or of any nation cooperating with the United States in the...

一种基于Cloud-P2P计算模型的恶意代码联合防御网络%Malicious code united-defense network based on Cloud-P2P model

Institute of Scientific and Technical Information of China (English)

徐小龙; 吴家兴; 杨庚

2012-01-01

The current anti-virus systems are usually unable io respond to endless emerging malicious codes in time. To sohe this problem, this paper proposed and constructed a new malicious code united-defense network based on the Cloud-P2P computing model. The Cloud-P2P model integrated the cloud computing and the P2P computing systems together organically. Servers and user terminals in the malicious code united-defense network carry out their own duties, forming a high-security collaborative defense network against malicious cooes and obtaining the whole group immunity quickly. It also proposed two kinds of hierarchical network topology, C-DHT and D-DHT, which were based on the distributed hash table technology and suitable for the Cloud-P2P computing model. By the introduction of mobile agent technology, realized vaccine agent and patrol agent of the malicious code defense united-network. The malicious code united-defense network based on the Cloud-P2P computing model has ideal performances, such as the network load balance, the rapid response, the comprehensive defense and the good compatibility.%针对目前的反病毒系统在应对恶意代码时通常具有的滞后性,提出并构建了一种新颖的基于CloudP2P计算模型的恶意代码联合防御网络.Cloud-P2P计算模型将云计算与对等计算进行有机融合.恶意代码联合防御网络系统中的集群服务器与用户终端群体联合组成了一个高安全防御网,协同防御恶意代码,并快速产生群体免疫力.为了提高系统的性能表现,提出适用于Cloud-P2P融合计算环境的两种基于分布式哈希表的层次式网络结构C-DHT和D-DHT,并通过引入移动agent技术实现了恶意代码联合防御网络中的疫苗agent和巡警agent.基于Cloud-P2P计算模型的恶意代码联合防御网络具有负载均衡、反应快捷、防御全面和兼容性良好等性能表现.

Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man

DEFF Research Database (Denmark)

Akerman, Ulrika; Edvinsson, Lars

2009-01-01

subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol. FINDINGS: The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 mumol/l was reached...... concentration and in time to maximal paracetamol concentration. The median maximal paracetamol concentration was 147 mumol/l for water, which is significantly higher than the median for rosehip drink with Lp299v,113.5 mumol/l, and than the median for rosehip-drink without Lp299v, 106.5 mumol/l (p = 0.002, and p...

78 FR 42889 - Pipeline Safety: Reminder of Requirements for Utility LP-Gas and LPG Pipeline Systems

Science.gov (United States)

2013-07-18

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part 192 [Docket No. PHMSA-2013-0097] Pipeline Safety: Reminder of Requirements for Utility LP-Gas and LPG Pipeline Systems AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION...

Ballistic missile defense effectiveness

Science.gov (United States)

Lewis, George N.

2017-11-01

The potential effectiveness of ballistic missile defenses today remains a subject of debate. After a brief discussion of terminal and boost phase defenses, this chapter will focus on long-range midcourse defenses. The problems posed by potential countermeasures to such midcourse defenses are discussed as are the sensor capabilities a defense might have available to attempt to discriminate the actual missile warhead in a countermeasures environment. The role of flight testing in assessing ballistic missile defense effectiveness is discussed. Arguments made about effectiveness by missile defense supporters and critics are summarized.

The National Guard Ballistic Missile Defense Mission minutemen at the Orgital Plane

OpenAIRE

Trenary, Ralph Hiram

2004-01-01

Approved for public release; distribution is unlimited This thesis examines the decision to assign the Ballistic Missile Defense mission to units of the Colorado and Alaska National Guard. The history of the Nike Ajax, Nike Hercules, Sentinel and Safeguard programs are examined to identify the origins of support for this decision. First-hand sources provide evidence that the National Guard performance in the Nike air defense program is a record of parity and some superiority to equivalent ...

76 FR 72391 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

Science.gov (United States)

2011-11-23

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Revised Defense Logistics Agency...

76 FR 71014 - Idaho Power Company, IDACORP Energy, L.P., IDACORP, Inc.; Notice of Petition

Science.gov (United States)

2011-11-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. IN03-9-000] Idaho Power Company, IDACORP Energy, L.P., IDACORP, Inc.; Notice of Petition Take notice that on September 9, 2011..., 2003,\\1\\ filed a petition to terminate Appendix B, Appendix C, and Appendix E to the Settlement...

77 FR 30589 - SteelRiver Infrastructure Partners LP, SteelRiver Infrastructure Associates LLC, SteelRiver...

Science.gov (United States)

2012-05-23

... will acquire all of the common stock of Patriot from Patriot Rail Holdings LLC, and thereby indirect... America LP, and Patriot Funding LLC--Control Exemption--Patriot Rail Corp., et al. SteelRiver... notice of exemption to acquire control of Patriot Rail Corp. (Patriot) and its rail carrier subsidiaries...

Silverleaf whitefly induces salicylic acid defenses and suppresses effectual jasmonic acid defenses.

Science.gov (United States)

Zarate, Sonia I; Kempema, Louisa A; Walling, Linda L

2007-02-01

The basal defenses important in curtailing the development of the phloem-feeding silverleaf whitefly (Bemisia tabaci type B; SLWF) on Arabidopsis (Arabidopsis thaliana) were investigated. Sentinel defense gene RNAs were monitored in SLWF-infested and control plants. Salicylic acid (SA)-responsive gene transcripts accumulated locally (PR1, BGL2, PR5, SID2, EDS5, PAD4) and systemically (PR1, BGL2, PR5) during SLWF nymph feeding. In contrast, jasmonic acid (JA)- and ethylene-dependent RNAs (PDF1.2, VSP1, HEL, THI2.1, FAD3, ERS1, ERF1) were repressed or not modulated in SLWF-infested leaves. To test for a role of SA and JA pathways in basal defense, SLWF development on mutant and transgenic lines that constitutively activate or impair defense pathways was determined. By monitoring the percentage of SLWF nymphs in each instar, we show that mutants that activate SA defenses (cim10) or impair JA defenses (coi1) accelerated SLWF nymphal development. Reciprocally, mutants that activate JA defenses (cev1) or impair SA defenses (npr1, NahG) slowed SLWF nymphal development. Furthermore, when npr1 plants, which do not activate downstream SA defenses, were treated with methyl jasmonate, a dramatic delay in nymph development was observed. Collectively, these results showed that SLWF-repressed, JA-regulated defenses were associated with basal defense to the SLWF.

Postirradiation examination results from the LP-FP-2 center fuel module

International Nuclear Information System (INIS)

Jensen, S.M.; Akers, D.W.

1990-01-01

The LP-FP-2 experiment was conducted on July 9, 1985 in the Loss of Fluid Test (LOFT) facility located at the Idaho National Engineering Laboratory (INEL). The primary purpose of this experiment was to provide information of the release, transport, and deposition of fission products and aerosols during a sever core damage event performed in a large scale nuclear reactor facility. Postirradiation nondestructive and destructive examinations of the fuel bundle provided information to assist in achieving this objective, as well as providing information on the material behavior and interactions that occurred within the fuel bundle during this sever core damage experiment. This was a large-scale integral test, incorporating an 11 x 11 array of fuel rods, control rods, and instrumentation tubes, with an active core length of 1.68 m. Peak temperatures in the fuel bundle exceeded 2100 K or approximately 4.5 min, with localized peak temperatures exceeding the melting point of the UO 2 fuel (3120 K). Large amounts of zircaloy oxidation and material relocation occurred during the experiment. The transient phase was terminated by a rapid reflood of cooling water, which resulted in significant oxidation and hydrogen generation. Zircaloy oxidation during the reflood period caused a rapid temperature excursion to occur in the upper two-thirds of the fuel bundle. This article summarizes the data and analysis from the postirradiation examinations of the LP-FP-2 fuel bundle. 12 refs., 39 figs., 8 tabs

Missile Defense: Ballistic Missile Defense System Testing Delays Affect Delivery of Capabilities

Science.gov (United States)

2016-04-28

Page 1 GAO-16-339R Ballistic Missile Defense 441 G St. N.W. Washington, DC 20548 April 28, 2016 Congressional Committees Missile Defense... Ballistic Missile Defense System Testing Delays Affect Delivery of Capabilities For over half a century, the Department of Defense (DOD) has been...funding efforts to develop a system to detect, track, and defeat enemy ballistic missiles. The current system—the Ballistic Missile Defense System

Listening to people to cure people: the LpCp - tool, an instrument to evaluate hospital humanization.

Science.gov (United States)

Buffoli, M; Bellini, E; Bellagarda, A; Di Noia, M; Nickolova, M; Capolongo, S

2014-01-01

In the healthcare environment, nowadays, only a few among the available evaluation systems pay enough attention to certain social sustainability aspects. Among these, humanization plays a key role in an environment, like hospitals, where the mental and physical well-being of patients and healthcare operators is crucial. Our research project, known as 'SustHealth', is focused on the deficiencies of the evaluation methodology and aims at developing an assessment system related to a questionnaire-based investigation capable of revealing the most influential conditions and dynamics in people's hospital experience, while also recommending areas in hospitals where efforts can be made to sustain improvement strategies. The humanization of healthcare structures began with a significant investigation to assess all the major evaluation tools in both hospitals - to better understand the physical and emotional interactions in the structure-user ratio - and other areas. This helped understand the strengths and criticalities of the systems that were examined. This first step also allowed to shed light on the most important aspects to keep in mind when developing an evaluation system. During the operational steps an all-new LpCp - tool (Listening to people to Cure people) was created, which includes a questionnaire-based investigation and processing software, and its application for beta-testing in a 600-bed hospital in Milan. The LpCp - tool proved to be effective and capable of finding the deficiencies and potential in the examined hospital. Considering different themes through alternative viewpoints (staff, patients/visitors, technicians, etc.), the tool has allowed underlining different perceptions of the same place and also provided sound information to guide healthcare management in taking informed decisions about specific problems or users. Former interesting results show an inadequate appraisal about e.g. on-site facilities or recreational activities and a lack of

A full cost analysis of the replacement of Naval Base, Guantanamo Bay's Marine ground defense force by the fleet antiterrorism security team

OpenAIRE

Ordona, Placido C.

2000-01-01

Constrained defense budgets and manpower resources have motivated the United States Marine Corps and the United States Navy to seek initiatives that maximize the efficient use and allocation of these diminishing resources. One such initiative is the restructuring of the Marine security presence at Naval Station, Guantanamo Bay, Cuba, through the replacement of the 350 man Marine Ground Defense Force with a smaller, rotating unit consisting of two platoons from the Fleet Antiterrorism Security...

Defense AT&L. Volume 40, Number 3, May-June 2011

Science.gov (United States)

2011-05-01

of Defense Technology and the Lessons of History IGA Robert Ranquet, IHEDN, Paris The United States has long relied on tech-nology to secure...Gen. Vincent Desportes, latest commandant of the French National War College, puts it in his recent book, La Guerre Probable ( Paris , 2008: Economica...engineering, he served as manager of the nuclear propul- sion department of the French navy’s pri- mary shipbuilding unit, the Brest division of the

Defense Analysis Students' SNA Research Captures the Attention of SOUTHCOM Leadership

OpenAIRE

Dionne, Patrick

2017-01-01

News Stories Archive U.S. Army Majs. Matthew Bauer, Andrew Maggard and Robert Murray, all students at the Naval Postgraduate School’s (NPS) Defense Analysis department, had the opportunity to brief members of United States Southern Command (SOUTHCOM).

78 FR 17389 - Texas Eastern Transmission, LP; Notice of Application for Certificate of Public Convenience and...

Science.gov (United States)

2013-03-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. CP13-84-000; PF12-19-000] Texas Eastern Transmission, LP; Notice of Application for Certificate of Public Convenience and Necessity and Authorization for Abandonment Take notice that on February 27, 2013, Texas Eastern...

78 FR 66892 - BASF Plant Science LP; Availability of Plant Pest Risk Assessment and Environmental Assessment...

Science.gov (United States)

2013-11-07

.... Kevin Shea, Administrator, Animal and Plant Health Inspection Service. [FR Doc. 2013-26701 Filed 11-6-13... DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service [Docket No. APHIS-2012-0028] BASF Plant Science LP; Availability of Plant Pest Risk Assessment and Environmental Assessment for...

75 FR 71122 - Erie Boulevard Hydropower L.P.; Notice of Scoping Meetings and Environmental Site Review

Science.gov (United States)

2010-11-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7518-012--New York] Erie Boulevard Hydropower L.P.; Notice of Scoping Meetings and Environmental Site Review November 15, 2010. Commission staff will be conducting two public scoping meetings and an environmental site review in support...

76 FR 2246 - Defense Support of Civil Authorities (DSCA)

Science.gov (United States)

2011-01-13

... Presidential nominating conventions, such as the United Nations General Assembly, Super Bowls, and the Group of..., direction, and control of the USD(P) shall: (1) Serve as the principal civilian advisor to the Secretary of... principal advisor to the Secretary of Defense for all DoD health policy shall: (1) Provide guidance and...

Defense Human Resources Activity > PERSEREC

Science.gov (United States)

Skip to main content (Press Enter). Toggle navigation Defense Human Resources Activity Search Search Defense Human Resources Activity: Search Search Defense Human Resources Activity: Search Defense Human Resources Activity U.S. Department of Defense Defense Human Resources Activity Overview

8 CFR 215.3 - Alien whose departure is deemed prejudicial to the interests of the United States.

Science.gov (United States)

2010-01-01

... States or the measures adopted by the United States or the United Nations for the defense of any other... for training and service in the Armed Forces of the United States and who fails to present a... undermine and defeat the military and defensive operations of the United States or of any nation cooperating...

Evaluation of smoothing in an iterative lp-norm minimization algorithm for surface-based source localization of MEG

Science.gov (United States)

Han, Jooman; Sic Kim, June; Chung, Chun Kee; Park, Kwang Suk

2007-08-01

The imaging of neural sources of magnetoencephalographic data based on distributed source models requires additional constraints on the source distribution in order to overcome ill-posedness and obtain a plausible solution. The minimum lp norm (0 temporal gyrus.

Inverse spectral results for Schrödinger operators on the unit interval with partial information given on the potentials

Science.gov (United States)

Amour, L.; Faupin, J.; Raoux, T.

2009-03-01

We pursue the analysis of the Schrödinger operator on the unit interval in inverse spectral theory initiated in the work of Amour and Raoux ["Inverse spectral results for Schrödinger operators on the unit interval with potentials in Lp spaces," Inverse Probl. 23, 2367 (2007)]. While the potentials in the work of Amour and Raoux belong to L1 with their difference in Lp (1≤p<∞), we consider here potentials in Wk,1 spaces having their difference in Wk,p, where 1≤p≤+∞, k ɛ{0,1,2}. It is proved that two potentials in Wk,1([0,1]) being equal on [a,1] are also equal on [0,1] if their difference belongs to Wk,p([0,a]) and if the number of their common eigenvalues is sufficiently high. Naturally, this number decreases as the parameter a decreases and as the parameters k and p increase.

Defense islands in bacterial and archaeal genomes and prediction of novel defense systems.

Science.gov (United States)

Makarova, Kira S; Wolf, Yuri I; Snir, Sagi; Koonin, Eugene V

2011-11-01

The arms race between cellular life forms and viruses is a major driving force of evolution. A substantial fraction of bacterial and archaeal genomes is dedicated to antivirus defense. We analyzed the distribution of defense genes and typical mobilome components (such as viral and transposon genes) in bacterial and archaeal genomes and demonstrated statistically significant clustering of antivirus defense systems and mobile genes and elements in genomic islands. The defense islands are enriched in putative operons and contain numerous overrepresented gene families. A detailed sequence analysis of the proteins encoded by genes in these families shows that many of them are diverged variants of known defense system components, whereas others show features, such as characteristic operonic organization, that are suggestive of novel defense systems. Thus, genomic islands provide abundant material for the experimental study of bacterial and archaeal antivirus defense. Except for the CRISPR-Cas systems, different classes of defense systems, in particular toxin-antitoxin and restriction-modification systems, show nonrandom clustering in defense islands. It remains unclear to what extent these associations reflect functional cooperation between different defense systems and to what extent the islands are genomic "sinks" that accumulate diverse nonessential genes, particularly those acquired via horizontal gene transfer. The characteristics of defense islands resemble those of mobilome islands. Defense and mobilome genes are nonrandomly associated in islands, suggesting nonadaptive evolution of the islands via a preferential attachment-like mechanism underpinned by the addictive properties of defense systems such as toxins-antitoxins and an important role of horizontal mobility in the evolution of these islands.

Goldwater-Nichols at 30: Defense Reform and Issues for Congress

Science.gov (United States)

2016-06-02

aborted . As the helicopters departed, one crashed into a C-130 aircraft carrying fuel and other servicemembers. All told, the United States lost...democratic, free-market economy . You may not realize that the second most difficult problem I can possibly envision is that of reforming the Defense

76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

Science.gov (United States)

2011-05-18

... DEPARTMENT OF DEFENSE Office of the Secretary [DOCKET ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised...

76 FR 53119 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

Science.gov (United States)

2011-08-25

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Comment Addressed on Notice of...

Cytoarchitecture of the human lateral occipital cortex: mapping of two extrastriate areas hOc4la and hOc4lp.

Science.gov (United States)

Malikovic, Aleksandar; Amunts, Katrin; Schleicher, Axel; Mohlberg, Hartmut; Kujovic, Milenko; Palomero-Gallagher, Nicola; Eickhoff, Simon B; Zilles, Karl

2016-05-01

The microstructural correlates of the functional segregation of the human lateral occipital cortex are largely unknown. Therefore, we analyzed the cytoarchitecture of this region in ten human post-mortem brains using an observer-independent and statistically testable parcellation method to define the position and extent of areas in the lateral occipital cortex. Two new cytoarchitectonic areas were found: an anterior area hOc4la and a posterior area hOc4lp. hOc4la was located behind the anterior occipital sulcus in rostral and ventral portions of this region where it occupies the anterior third of the middle and inferior lateral occipital gyri. hOc4lp was found in caudal and dorsal portions of this region where it extends along the superior and middle lateral occipital gyri. The cytoarchitectonic areas were registered to 3D reconstructions of the corresponding brains, which were subsequently spatially normalized to the Montreal Neurological Institute reference space. Continuous probabilistic maps of both areas based on the analysis of ten brains were generated to characterize their inter-subject variability in location and size. The maps of hOc4la and hOc4lp were then used as seeds for meta-analytic connectivity modeling and quantitative functional decoding to identify their co-activation patterns and assignment to functional domains. Convergent evidence from their location, topography, size, functional domains and connectivity indicates that hOc4la and hOc4lp are the potential anatomical correlates of the functionally defined lateral occipital areas LO-1 and LO-2.

75 FR 76423 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

Science.gov (United States)

2010-12-08

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of Defense. ACTION: Notice of Closed Meeting. SUMMARY: Pursuant to the...

76 FR 28960 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

Science.gov (United States)

2011-05-19

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of Defense. ACTION: Notice of Closed Meeting. SUMMARY: Pursuant to the...

75 FR 13755 - Freeport LNG Development, L.P.; Application To Amend Blanket Authorization To Export Liquefied...

Science.gov (United States)

2010-03-23

... Delaware limited partnership with one general partner, Freeport LNG-GP, Inc., a Delaware corporation, which...). Freeport LNG's limited partners are: (1) Freeport LNG Investments, LLLP, a Delaware limited liability limited partnership, which owns a 45% limited partnership interest in Freeport LNG; (2) Cheniere FLNG, L.P...

Transforming Defense

National Research Council Canada - National Science Library

Lamb, Christopher J; Bunn, M. E; Lutes, Charles; Cavoli, Christopher

2005-01-01

.... Despite the resources and attention consumed by the war on terror, and recent decisions by the White House to curtail the growth of defense spending, the senior leadership of the Department of Defense (DoD...

Mental incapacity defenses at the War Crimes Tribunal: questions and controversy.

Science.gov (United States)

Sparr, Landy F

2005-01-01

Following a report from the Secretary General in May 1993, the United Nations Security Council adopted Resolution 827 and its Statute establishing an International War Crimes Tribunal for the Former Yugoslavia (ICTY) located in The Hague, The Netherlands. Although such action has been discussed in the past, this is the first time the international community has established a tribunal to indict and try individuals for war crimes. The crimes had been previously "created" by multilateral international treaties. The ICTY Rules of Procedure and Evidence allowed for "any special defense, including that of diminished or lack of mental responsibility." Precise legal parameters of the defense were not specified. In 1998, a defendant at the ICTY "Celebici" Trial named Esad Landzo raised the defense of diminished mental responsibility. The Celebici Trial Chamber thus became the first legal body to consider reduced mental capacity as it applies to international criminal law. This article is an examination of the application of the affirmative defense of diminished responsibility at the ICTY and relates the process to the need for further definition of mental incapacity defenses at the newly established International Criminal Court (ICC). At the ICC preparatory commission, drafting material elements of crimes was emphasized, with less consideration given to mental elements. That diminished capacity and diminished-responsibility defenses have often confused scholars and practitioners alike is explored in this article with suggestions for further directions.

Alternative conventional defense postures in the European theater

International Nuclear Information System (INIS)

Brauch, H.D.; Kennedy, R.

1992-01-01

This book is about change: in the Soviet Union, in Eastern Europe, and how we in the West should respond. Few observers of the international scene, even in their wildest dreams, could have imagined the course of events that have taken place in Europe since early 1989. The communist system came to a dead end. Old social, economic, political, and psychological recipes no longer were acceptable, either in the Soviet Union or in Eastern Europe. Soviet leadership had only two choices: repress change in Eastern Europe and demand continued sacrifices from its own people, or press forward on the road of economic reform and political restructuring at home and the pursuit of new relationships abroad. The three volumes on Alternative Conventional Defense Postures in the European Theater contributed significantly to the current debate in Europe and in the United States on the future of European security. As an outgrowth of a German-American workshop at the Army War College in Carlisle, Pennsylvania, the two editors have succeeded in bringing together statesmen, soldiers, and civilian defense specialist from the Federal Republic, the United States, and the Soviet Union, who represent a variety of schools of political and strategic thinking

Defense and attack of complex and dependent systems

International Nuclear Information System (INIS)

Hausken, Kjell

2010-01-01

A framework is constructed for how to analyze the strategic defense of an infrastructure subject to attack by a strategic attacker. Merging operations research, reliability theory, and game theory for optimal analytical impact, the optimization program for the defender and attacker is specified. Targets can be in parallel, series, combined series-parallel, complex, k-out-of-n redundancy, independent, interdependent, and dependent. The defender and attacker determine how much to invest in defending versus attacking each of multiple targets. A target can have economic, human, and symbolic values, subjectively assessed by the defender and attacker. A contest success function determines the probability of a successful attack on each target, dependent on the investments by the defender and attacker into each target, and on characteristics of the contest. The defender minimizes the expected damage plus the defense costs. The attacker maximizes the expected damage minus the attack costs. Each agent is concerned about how his investments vary across the targets, and the impact on his utilities. Interdependent systems are analyzed where the defense and attack on one target impacts all targets. Dependent systems are analyzed applying Markov analysis and repeated games where a successful attack on one target in the first period impacts the unit costs of defense and attack, and the contest intensity, for the other target in the second period.

Defense and attack of complex and dependent systems

Energy Technology Data Exchange (ETDEWEB)

Hausken, Kjell, E-mail: kjell.hausken@uis.n [Faculty of Social Sciences, University of Stavanger, N-4036 Stavanger (Norway)

2010-01-15

A framework is constructed for how to analyze the strategic defense of an infrastructure subject to attack by a strategic attacker. Merging operations research, reliability theory, and game theory for optimal analytical impact, the optimization program for the defender and attacker is specified. Targets can be in parallel, series, combined series-parallel, complex, k-out-of-n redundancy, independent, interdependent, and dependent. The defender and attacker determine how much to invest in defending versus attacking each of multiple targets. A target can have economic, human, and symbolic values, subjectively assessed by the defender and attacker. A contest success function determines the probability of a successful attack on each target, dependent on the investments by the defender and attacker into each target, and on characteristics of the contest. The defender minimizes the expected damage plus the defense costs. The attacker maximizes the expected damage minus the attack costs. Each agent is concerned about how his investments vary across the targets, and the impact on his utilities. Interdependent systems are analyzed where the defense and attack on one target impacts all targets. Dependent systems are analyzed applying Markov analysis and repeated games where a successful attack on one target in the first period impacts the unit costs of defense and attack, and the contest intensity, for the other target in the second period.

78 FR 65977 - Board of Visitors, United States Military Academy (USMA)

Science.gov (United States)

2013-11-04

[email protected]us.army.mil . 7. Due to the lapse of appropriations, the Department of Defense cancelled the... DEPARTMENT OF DEFENSE Department of the Army Board of Visitors, United States Military Academy... the Sunshine Act of 1976 (5 U.S.C. 552b, as amended), and 41 CFR 102-3.150, the Department of Defense...

Home - Defense Technology Security Administration

Science.gov (United States)

by @dtsamil Defense Technology Security Administration Mission, Culture, and History Executive Official seal of Defense Technology Security Administration Official seal of Defense Technology Security Administration OFFICE of the SECRETARY of DEFENSE Defense Technology Security Administration

Optimizing Active Cyber Defense

OpenAIRE

Lu, Wenlian; Xu, Shouhuai; Yi, Xinlei

2016-01-01

Active cyber defense is one important defensive method for combating cyber attacks. Unlike traditional defensive methods such as firewall-based filtering and anti-malware tools, active cyber defense is based on spreading "white" or "benign" worms to combat against the attackers' malwares (i.e., malicious worms) that also spread over the network. In this paper, we initiate the study of {\\em optimal} active cyber defense in the setting of strategic attackers and/or strategic defenders. Specific...

75 FR 3179 - Defense Federal Acquisition Regulation Supplement; Trade Agreements-Costa Rica and Peru (DFARS...

Science.gov (United States)

2010-01-20

...-AG31 Defense Federal Acquisition Regulation Supplement; Trade Agreements--Costa Rica and Peru (DFARS... respect to Costa Rica, and the United States-Peru Trade Promotion Agreement. The trade agreements waive... States Free Trade Agreement with respect to Costa Rica and the United States-Peru Trade Promotion...

76 FR 63918 - Tesoro Refining and Marketing Company v. SFPP, L.P.; Notice of Complaint

Science.gov (United States)

2011-10-14

... and Marketing Company v. SFPP, L.P.; Notice of Complaint Take notice that on October 5, 2011, pursuant... section 1(13) of the Interstate Commerce Act (ICA), 49 U.S.C. App. 13(1), Tesoro Refining and Marketing... document is added to a subscribed docket(s). For assistance with any FERC Online service, please e-mail...

Physics of a ballistic missile defense - The chemical laser boost-phase defense

Science.gov (United States)

Grabbe, Crockett L.

1988-01-01

The basic physics involved in proposals to use a chemical laser based on satellites for a boost-phase defense are investigated. After a brief consideration of simple physical conditions for the defense, a calculation of an equation for the number of satellites needed for the defense is made along with some typical values of this for possible future conditions for the defense. Basic energy and power requirements for the defense are determined. A sumary is made of probable minimum conditions that must be achieved for laser power, targeting accuracy, number of satellites, and total sources for power needed.

Investment in defense and cost of predator-induced defense along a resource gradient

DEFF Research Database (Denmark)

Steiner, Uli

2007-01-01

An organism's investment in different traits to reduce predation is determined by the fitness benefit of the defense relative to the fitness costs associated with the allocation of time and resources to the defense. Inherent tradeoffs in time and resource allocation should result in differential...... investment in defense along a resource gradient, but competing models predict different patterns of investment. There are currently insufficient empirical data on changes in investment in defensive traits or their costs along resource gradients to differentiate between the competing allocation models....... In this study, I exposed tadpoles to caged predators along a resource gradient in order to estimate investment in defense and costs of defense by assessing predator-induced plasticity. Induced defenses included increased tail depth, reduced feeding, and reduced swimming activity; costs associated...

Unfolding Green Defense

DEFF Research Database (Denmark)

Larsen, Kristian Knus

2015-01-01

In recent years, many states have developed and implemented green solutions for defense. Building on these initiatives NATO formulated the NATO Green Defence Framework in 2014. The framework provides a broad basis for cooperation within the Alliance on green solutions for defense. This report aims...... to inform and support the further development of green solutions by unfolding how green technologies and green strategies have been developed and used to handle current security challenges. The report, initially, focuses on the security challenges that are being linked to green defense, namely fuel...... consumption in military operations, defense expenditure, energy security, and global climate change. The report then proceeds to introduce the NATO Green Defence Framework before exploring specific current uses of green technologies and green strategies for defense. The report concludes that a number...

Approaches for Scaling Back the Defense Department’s Budget Plans

Science.gov (United States)

2013-03-01

of an overall strat- egy for curtailing defense costs, or some variation of that approach could be adopted instead. (Ways in which the general... tempo (activities such as steaming days for Navy ships and flying hours for the ser- vices’ aviation components) of the units that remained in the...Mosher and Matthew S. Goldberg . Adam Talaber analyzed the costs to operate individual military units. David Berteau of the Center for Strategic and

Science and Technology of Nanostructures in the Department of Defense

International Nuclear Information System (INIS)

Murday, James S.

1999-01-01

The United States Department of Defense maintains a research and development program in nanostructures with special attention to miniaturization of information technology devices, nanostructured materials, and nanobiotechnology for detection of biological agents. This article provides a brief guide to those DoD funding officers and research scientists actively interested in nanostructures

Coupled-Flow Simulation of HP-LP Turbines Has Resulted in Significant Fuel Savings

Science.gov (United States)

Veres, Joseph P.

2001-01-01

Our objective was to create a high-fidelity Navier-Stokes computer simulation of the flow through the turbines of a modern high-bypass-ratio turbofan engine. The simulation would have to capture the aerodynamic interactions between closely coupled high- and low-pressure turbines. A computer simulation of the flow in the GE90 turbofan engine's high-pressure (HP) and low-pressure (LP) turbines was created at GE Aircraft Engines under contract with the NASA Glenn Research Center. The three-dimensional steady-state computer simulation was performed using Glenn's average-passage approach named APNASA. The areas upstream and downstream of each blade row mutually interact with each other during engine operation. The embedded blade row operating conditions are modeled since the average passage equations in APNASA actively include the effects of the adjacent blade rows. The turbine airfoils, platforms, and casing are actively cooled by compressor bleed air. Hot gas leaks around the tips of rotors through labyrinth seals. The flow exiting the high work HP turbines is partially transonic and, therefore, has a strong shock system in the transition region. The simulation was done using 121 processors of a Silicon Graphics Origin 2000 (NAS 02K) cluster at the NASA Ames Research Center, with a parallel efficiency of 87 percent in 15 hr. The typical average-passage analysis mesh size per blade row was 280 by 45 by 55, or approx.700,000 grid points. The total number of blade rows was 18 for a combined HP and LP turbine system including the struts in the transition duct and exit guide vane, which contain 12.6 million grid points. Design cycle turnaround time requirements ran typically from 24 to 48 hr of wall clock time. The number of iterations for convergence was 10,000 at 8.03x10(exp -5) sec/iteration/grid point (NAS O2K). Parallel processing by up to 40 processors is required to meet the design cycle time constraints. This is the first-ever flow simulation of an HP and LP

Induction of defensive enzymes (isozymes) during defense against ...

African Journals Online (AJOL)

user

2012-09-06

Sep 6, 2012 ... defense against two different fungal pathogens in pear calli ... study the biochemical changes in relation to plant defense ... relatively easy to manipulate by empirical means, allowing for a ... earlier phase, and the degree of rot was significantly ..... resistance of fruit, and they play an important role in the.

77 FR 52018 - Oxy Midstream Strategic Development, LLC, Magellan Midstream Partners, L.P.; Notice of Petition...

Science.gov (United States)

2012-08-28

... Strategic Development, LLC, Magellan Midstream Partners, L.P.; Notice of Petition for Declaratory Order Take... will transport crude oil from the Permian Basin, which is sourced in West Texas and New Mexico, to the... available for review in the Commission's Public Reference Room in Washington, DC. There is an eSubscription...

United States Strategy for Mexico

National Research Council Canada - National Science Library

Centner, Robert C

2005-01-01

The security and stability of Mexico is of national interest to the United States, and a strong, effective alliance between the two countries is pivotal to our national defense strategy and economic prosperity...

Defense Waste Processing Facility, Savannah River Plant

International Nuclear Information System (INIS)

After 10 years of research, development, and testing, the US Department of Energy is building a new facility which will prepare high-level radioactive waste for permanent disposal. The Defense Waste Processing Facility, known as the DWPF, will be the first production-scale facility of its kind in the United States. In the DWPF, high-level waste produced by defense activities at the Savannah River Plant will be processed into a solid form, borosilicate glass, suitable for permanent off-site geologic disposal. With construction beginning in the fall of 1983, the DWPT is scheduled to be operational in 1989. By 2005, the DWPF will have immobilized the backlog of high-level waste which has been accumulating in storage tanks at the Savannah River Plant since 1954. Canisters of the immobilized waste will then be ready for permanent disposal deep under the ground, safely isolated from the environment

78 FR 18876 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

Science.gov (United States)

2013-03-28

... Agreement. The Republic of Korea is already party to the World Trade Organization Government Procurement...) Agreement on Government Procurement (GPA). Although the rule now opens up Government procurement to the... 48 CFR Parts 225 and 252 Government procurement. Kortnee Stewart, Editor, Defense Acquisition...

Defense.gov Special Report: Defense Officials Release Operational Energy

Science.gov (United States)

, DOD Operational Energy Strategy DOD's Operational Energy Strategy will guide the Defense Department to operations are among the goals of the Defense Department's operational energy strategy, a senior Pentagon operational energy footprint, experts in solar power, microgrids and "smart" generators recently

75 FR 52732 - Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee

Science.gov (United States)

2010-08-27

... Committee; Missile Defense Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Renewal of..., the Department of Defense gives notice that it is renewing the charter for the Missile Defense... Director, Missile Defense Agency, independent advice and recommendations on all matters relating to missile...

Nonlinear optics in the LP(02) higher-order mode of a fiber.

Science.gov (United States)

Chen, Y; Chen, Z; Wadsworth, W J; Birks, T A

2013-07-29

The distinct disperion properties of higher-order modes in optical fibers permit the nonlinear generation of radiation deeper into the ultraviolet than is possible with the fundamental mode. This is exploited using adiabatic, broadband mode convertors to couple light efficiently from an input fundamental mode and also to return the generated light to an output fundamental mode over a broad spectral range. For example, we generate visible and UV supercontinuum light in the LP(02) mode of a photonic crystal fiber from sub-ns pulses with a wavelength of 532 nm.

United States Department of Defense Agency Financial Report for Fiscal Year 2013. Financial Section

Science.gov (United States)

2013-01-01

capacity for operating landfills and life expectancy in years for all other assets. The Department expenses the full cost to clean up contamination for...construction, and rehabilitation projects on inland waterways. The BFS manages and invests for the Trust Fund. Defense Commissary Agency Surcharge Trust

Strategic Framework for the Defense Acquisition System Understanding Defense Consolidation

National Research Council Canada - National Science Library

Potts, Anthony W

2007-01-01

...% of defense product sales annually. Defense consolidation has diminished the flexibility required for surge capacity, diminished competitive innovations in products, and reduced competitive pricing based on multiple sources for products...

Stakeholder participation for the legacy ponds and legacy silos (LP and LS) facility at Sellafield, Cumbria. UK: the nature and effectiveness of the dialogue - 16030

International Nuclear Information System (INIS)

Whitton, John

2009-01-01

The Legacy Ponds and Silos (LP and S) facilities are part of the UK nuclear legacy located at the Sellafield Site, Cumbria. There are four individual facilities containing nuclear wastes that have accumulated over a period of approximately 50 years. Waste retrieval and conditioning, in preparation for decommissioning, is currently being carried out by the site operator. LP and S have recently proposed a re-engagement with stakeholders following the initial engagement in December 2005. This paper reviews this earlier engagement in terms of the nature of dialogue that was carried out when compared against definitions of deliberation provided in the literature. The aim of this paper is to provide those planning future engagement with a better understanding of how the nature of dialogue can vary and uses participation and deliberation as indicators of effective engagement. A concern of those working towards a programme of effective stakeholder participation in 2005 was how to ensure genuine dialogue and stakeholder representation in such a strictly controlled and regulated environment with a technical complexity that challenges technical specialist and lay person alike. LP and S recognised that effective dialogue with stakeholders on the available technical options and their associated societal impacts would form a significant part of this process if options were to prove resilient. However, the challenge presented to LP and S was how to engage stakeholders on a variety of projects, whilst ensuring the output could be used by the projects as part of their technical decision making. Initial contact was made with stakeholders in December 2005, as part of a 'Baseline' Best Practicable Environmental Option (BPEO) study. A BPEO study leads to decisions on waste management based on an integrated assessment of alternative options, on the basis of factors such as the occupational and environmental risks, the environmental impacts, costs and social implications of the options

Implementing Effective Affordability Constraints for Defense Acquisition Programs

Science.gov (United States)

2014-03-01

version that appears in the Pentagon Digital Library at http://www.whs.mil/library/mildoc/DODD.html. See also Joe Ferrara , “DOD’s 5000 Documents...costs.16 E. MIDS MIDS is a multinational (United States, France, Germany, Italy , Spain) cooperative development program with U.S. Joint Service...Congressional Research Service, 15 January 2014. Ferrara , Joe. “DOD’s 5000 Documents: Evolution and Change in Defense Acquisition Policy.” Acquisition

78 FR 77770 - Aldine Capital Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business...

Science.gov (United States)

2013-12-24

... financing to Koontz-Wagner Maintenance Services, LLC., 3801 Voorde Drive, South Bend, IN 46628. The....P. is an Associate of Aldine Capital Fund II, L.P. and owns more than ten percent of Koontz- Wagner...

'LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering.

Science.gov (United States)

Yeang, Calvin; Witztum, Joseph L; Tsimikas, Sotirios

2015-06-01

The measurement that is termed 'LDL-cholesterol' (LDL-C) includes the cholesterol content of lipoprotein(a) [Lp(a)-C], which can contribute approximately 30-45% to measured LDL-C levels as a percentage of its mass. We review the implications of achieved very low LDL-C levels in patients treated with potent LDL-C-lowering agents in the context of varying Lp(a) levels. Combination therapy with statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors can lower LDL-C to unprecedentedly low levels. Recent PCSK9 trials have shown that routine achievement of mean LDL-C less than 50 mg/dl is feasible, along with the modest reductions in Lp(a). Many patients will achieve LDL-C less than 25 mg/dl with concomitantly elevated Lp(a) levels that contribute substantially to the measured 'LDL-C'. Therefore, it is possible that some of these patients may have little to no circulating LDL-C. As the new era of ultralow LDL-C levels ensues, it is imperative to understand the contribution of Lp(a)-C to measured LDL-C and the consequences of achieving ultralow or potentially absent LDL-C in the setting of elevated Lp(a) levels and possibly free apo(a). We review this concept and suggest avenues of research, including analyses of existing datasets in current clinical trials and new research studies, to understand its pathophysiological and clinical significance.

Strategic Defense Initiative: Splendid Defense or Pipe Dream? Headline Series No. 275.

Science.gov (United States)

Armstrong, Scott; Grier, Peter

This pamphlet presents a discussion of the various components of President Reagan's Strategic Defense Initiative (SDI) including the problem of pulling together various new technologies into an effective defensive system and the politics of the so-called "star wars" system. An important part of the defense initiative is the…

Assessment of core damage models in SCDAP/RELAP5 during OECD LOFT LP-FP-2

International Nuclear Information System (INIS)

Coryell, E.W.

1991-01-01

The US Nuclear Regulatory Commission has sponsored a program to apply the SCDAP/RELAP5 code to analysis of the transient and reflood phases of the OECD LOFT LP-FP-2 Experiment. The principal objectives of the LP-FP-2 experiment were to determine the fission product release from the fuel during the early phases of a severe fuel damage scenario and to examine the phenomena controlling fission product transport in a vapor/aerosol environment. Calculations with the SCDAP/RELAP5 code, developed at the INEL with NRC support, have been performed to (1) examine the phenomena controlling the progression of both transient and reflood phases of the experiment, (2) enhance our understanding of the phenomena occurring during reflood and add credence to the postulated phenomenological sequence, (3) assess the ability of SCDAP/RELAP5 to examine severe fuel damage issues and phenomena, and (4) identify code strengths and deficiencies with the intent of prioritizing code improvements. Results indicate that the code is able to analyze the early phases of severe fuel damage reasonably well, with potential deficiencies in modelling interaction between molten control rod material and intact fuel

Immunoexpression of Interleukin-22 and Interleukin-23 in Oral and Cutaneous Lichen Planus Lesions: A Preliminary Study

Directory of Open Access Journals (Sweden)

Jun Chen

2013-01-01

Full Text Available Interleukin- (IL- 22 is the signature cytokine of T-helper (Th 22 cells, and IL-23 is required for IL-22 production. The objective of this study was to examine the immunoexpression of IL-22 and IL-23 in archival paraffin-embedded biopsy specimens from oral LP (n=42 and cutaneous LP (n=38 against normal control tissues. The results showed that the percentage of cells expressing IL-22 and IL-23 in LP were significantly higher in LP compared to controls, respectively (both P<0.001. The correlation between IL-22 and IL-23 expression was significant (P<0.05. Moreover, the percentage of cells expressing IL-22 and IL-23 in oral LP were significantly higher than cutaneous LP (P<0.05. Collectively, our findings demonstrated that the increased expression of IL-22 and IL-23 in LP lesions could play roles in the pathogenesis of LP. Moreover, oral LP expressing IL-22 and IL-23 was higher than cutaneous LP, probably due to Th22 cells as an important component of oral mucosal host defense against oral microbiota and tissue antigens. This may be associated with the difference in clinical behaviour of the two variants of the disease.

75 FR 39244 - Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for...

Science.gov (United States)

2010-07-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-45-000] Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for Clarification, or in the Alternative, Request for Limited Waiver June 30, 2010. Take notice that on June 25, 2010, Arizona Public...

76 FR 59682 - Erie Boulevard Hydropower L.P.; Notice of Dispute Resolution Panel Meeting and Technical Conference

Science.gov (United States)

2011-09-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 7518-012] Erie Boulevard Hydropower L.P.; Notice of Dispute Resolution Panel Meeting and Technical Conference On September 16, 2011, Commission staff, in response to the filing of notice of study dispute by the New York State Department of...

Financial Reporting Procedures for Defense Distribution Depots - Defense Logistics Agency Business Area of the Defense Business Operations Fund

National Research Council Canada - National Science Library

Young, Shelton

1994-01-01

In our audit of the FY 1993 Financial Statements for the Distribution Depots--Defense Logistics Agency Business Mea of the Defense Business Operations Fund, we evaluated procedures and controls used...

Defense styles of pedophilic offenders.

Science.gov (United States)

Drapeau, Martin; Beretta, Véronique; de Roten, Yves; Koerner, Annett; Despland, Jean-Nicolas

2008-04-01

This pilot study investigated the defense styles of pedophile sexual offenders. Interviews with 20 pedophiles and 20 controls were scored using the Defense Mechanisms Rating Scales. Results showed that pedophiles had a significantly lower overall defensive functioning score than the controls. Pedophiles used significantly fewer obsessional-level defenses but more major image-distorting and action-level defenses. Results also suggested differences in the prevalence of individual defenses where pedophiles used more dissociation, displacement, denial, autistic fantasy, splitting of object, projective identification, acting out, and passive aggressive behavior but less intellectualization and rationalization.

Critical Electronic Data Loss Perceptions of United States Military Contractors

Science.gov (United States)

Singletary, Tod J.

2017-01-01

The United States Military has become increasingly dependent upon technology to meet its mission objectives with a consequence being greater dependence on civilian defense contractors to provide specialized services in support of high-tech mission requirements. Modern military defense contractors have also become dependent upon reliable and secure…

Defensive medicine among neurosurgeons in the Netherlands: a national survey.

Science.gov (United States)

Yan, Sandra C; Hulsbergen, Alexander F C; Muskens, Ivo S; van Dam, Marjel; Gormley, William B; Broekman, Marike L D; Smith, Timothy R

2017-12-01

In defensive medicine, practice is motivated by legal rather than medical reasons. Previous studies have analyzed the correlation between perceived medico-legal risk and defensive behavior among neurosurgeons in the United States, Canada, and South Africa, but not yet in Europe. The aim of this study is to explore perceived liability burdens and self-reported defensive behaviors among neurosurgeons in the Netherlands and compare their practices with their non-European counterparts. A survey was sent to 136 neurosurgeons. The survey included questions from several domains: surgeon characteristics, patient demographics, type of practice, surgeon liability profile, policy coverage, defensive practices, and perception of the liability environment. Survey responses were analyzed and summarized. Forty-five neurosurgeons filled out the questionnaire (response rate of 33.1%). Almost half (n = 20) reported paying less than 5% of their income to annual malpractice premiums. Nearly all respondents view their insurance premiums as a minor or no burden (n = 42) and are confident that in their coverage is sufficient (n = 41). Most neurosurgeons (n = 38) do not see patients as "potential lawsuits". Relative to their American peers, Dutch neurosurgeons view their insurance premiums as less burdensome, their patients as a smaller legal threat, and their practice as less risky in general. They are sued less often and engage in fewer defensive behaviors than their non-European counterparts. The medico-legal climate in the Netherlands may contribute to this difference.

Recognizing Plant Defense Priming

NARCIS (Netherlands)

Martinez-Medina, Ainhoa; Flors, Victor; Heil, Martin; Mauch-Mani, Brigitte; Pieterse, Corné M J|info:eu-repo/dai/nl/113115113; Pozo, Maria J; Ton, Jurriaan; van Dam, Nicole M; Conrath, Uwe

2016-01-01

Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in

Recognizing plant defense priming

NARCIS (Netherlands)

Martinez-Medina, A.; Flors, V.; Heil, M.; Mauch-Mani, B.; Pieterse, C.M.J.; Pozo, M.J.; Ton, J.; Van Dam, N.M.; Conrath, U.

2016-01-01

Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in

Plant defense against insect herbivores

DEFF Research Database (Denmark)

Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

2013-01-01

, defense compounds. These bioactive specialized plant defense compounds may repel or intoxicate insects, while defense proteins often interfere with their digestion. Volatiles are released upon herbivory to repel herbivores, attract predators or for communication between leaves or plants, and to induce......Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar...... defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects...

78 FR 54886 - Texas Eastern Transmission, LP; Notice of Intent To Prepare an Environmental Assessment for the...

Science.gov (United States)

2013-09-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF13-15-000] Texas Eastern Transmission, LP; Notice of Intent To Prepare an Environmental Assessment for the Planned Ohio Pipeline Energy Network Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meetings The staff of the Federal Energy...

Other Defense Organizations and Defense Finance and Accounting Service Controls Over High-Risk Transactions Were Not Effective

Science.gov (United States)

2016-03-28

Defense Organizations and Defense Finance and Accounting Service Controls Over High-Risk Transactions Were Not Effective M A R C H 2 8 , 2 0 1 6...Defense Organizations and Defense Finance and Accounting Service Controls Over High-Risk Transactions Were Not Effective Visit us at www.dodig.mil... FINANCE AND ACCOUNTING SERVICE DIRECTOR, DEFENSE HEALTH AGENCY SUBJECT: Other Defense Organizations and Defense Finance and Accounting Service

DEFENSE PROGRAMS RISK MANAGEMENT FRAMEWORK

Directory of Open Access Journals (Sweden)

Constantin PREDA

2012-01-01

Full Text Available For the past years defense programs have faced delays in delivering defense capabilities and budget overruns. Stakeholders are looking for ways to improve program management and the decision making process given the very fluid and uncertain economic and political environment. Consequently, they have increasingly resorted to risk management as the main management tool for achieving defense programs objectives and for delivering the defense capabilities strongly needed for the soldiers on the ground on time and within limited defense budgets. Following a risk management based decision-making approach the stakeholders are expected not only to protect program objectives against a wide range of risks but, at the same time, to take advantage of the opportunities to increase the likelihood of program success. The prerequisite for making risk management the main tool for achieving defense programs objectives is the design and implementation of a strong risk management framework as a foundation providing an efficient and effective application of the best risk management practices. The aim of this paper is to examine the risk management framework for defense programs based on the ISO 31000:2009 standard, best risk management practices and the defense programs’ needs and particularities. For the purposes of this article, the term of defense programs refers to joint defense programs.

Silverleaf Whitefly Induces Salicylic Acid Defenses and Suppresses Effectual Jasmonic Acid Defenses1[W][OA

Science.gov (United States)

Zarate, Sonia I.; Kempema, Louisa A.; Walling, Linda L.

2007-01-01

The basal defenses important in curtailing the development of the phloem-feeding silverleaf whitefly (Bemisia tabaci type B; SLWF) on Arabidopsis (Arabidopsis thaliana) were investigated. Sentinel defense gene RNAs were monitored in SLWF-infested and control plants. Salicylic acid (SA)-responsive gene transcripts accumulated locally (PR1, BGL2, PR5, SID2, EDS5, PAD4) and systemically (PR1, BGL2, PR5) during SLWF nymph feeding. In contrast, jasmonic acid (JA)- and ethylene-dependent RNAs (PDF1.2, VSP1, HEL, THI2.1, FAD3, ERS1, ERF1) were repressed or not modulated in SLWF-infested leaves. To test for a role of SA and JA pathways in basal defense, SLWF development on mutant and transgenic lines that constitutively activate or impair defense pathways was determined. By monitoring the percentage of SLWF nymphs in each instar, we show that mutants that activate SA defenses (cim10) or impair JA defenses (coi1) accelerated SLWF nymphal development. Reciprocally, mutants that activate JA defenses (cev1) or impair SA defenses (npr1, NahG) slowed SLWF nymphal development. Furthermore, when npr1 plants, which do not activate downstream SA defenses, were treated with methyl jasmonate, a dramatic delay in nymph development was observed. Collectively, these results showed that SLWF-repressed, JA-regulated defenses were associated with basal defense to the SLWF. PMID:17189328

Characteristics of Low-Priced Solar Photovoltaic Systems in the United States

Energy Technology Data Exchange (ETDEWEB)

Nemet, Gregory F. [Univ. of Wisconsin, Madison, WI (United States); O' Shaughnessy, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States); Wiser, Ryan H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Darghouth, Naim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Barbose, Galen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gillingham, Ken [Yale Univ., New Haven, CT (United States); Rai, Varun [Univ. of Texas, Austin, TX (United States)

2016-01-01

Despite impressive recent cost reductions, there is wide dispersion in the prices of installed solar photovoltaic (PV) systems. We identify the most important factors that make a system likely to be low priced (LP). Our sample consists of detailed characteristics for 42,611 small-scale (< 15 kW) PV systems installed in 15 U.S. states during 2013. Using four definitions of LP systems, we compare LP and non-LP systems and find statistically significant differences in nearly all factors explored, including competition, installer scale, markets, demographics, ownership, policy, and system components. Logit and probit model results robustly indicate that LP systems are associated with markets with few active installers; experienced installers; customer ownership; large systems; retrofits; and thin-film, low-efficiency, and Chinese modules. We also find significant differences across states, with LP systems much more likely to occur in some than in others. Our focus on the left tail of the price distribution provides implications for policy that are distinct from recent studies of mean prices. While those studies find that PV subsidies increase mean prices, we find that subsidies also generate LP systems. PV subsidies appear to simultaneously shift and broaden the price distribution. Much of this broadening occurs in a particular location, northern California, which is worthy of further investigation with new data.

76 FR 77583 - Vantage Pipeline US LP; Notice of Intent To Prepare an Environmental Assessment and Request for...

Science.gov (United States)

2011-12-13

... DEPARTMENT OF STATE [Public Notice 7728] Vantage Pipeline US LP; Notice of Intent To Prepare an... Section 106 of the National Historic Preservation Act for the Proposed Vantage Pipeline Project December 9... (EA) that will discuss the environmental impacts of the Vantage Pipeline Project involving...

78 FR 67437 - Bureau of Political-Military Affairs, Directorate of Defense Trade Controls: Notifications to the...

Science.gov (United States)

2013-11-12

... improved Air Defense Ground Environment (ADGE) System for end-use by NATO. The United States government is... the Weapons Bay Door Drive System for all variants of the F-35 Lightning II aircraft. The United... support of the manufacture, assembly and installation of the Environmental Control System (ECS) used on...

76 FR 40768 - Bureau of Political-Military Affairs: Directorate of Defense Trade Controls; Notifications to the...

Science.gov (United States)

2011-07-11

... defense services to Russia for the RD-180 Liquid Propellant Rocket Engine Program. The United States... select F110-GE-129 engine components for end-use by the Republic of Korea Air Force. The United States..., depot level repair, and overhaul services on components of various military fixed and rotary wing...

Rethinking Defensive Information Warfare

National Research Council Canada - National Science Library

French, Geoffrey S

2004-01-01

.... This paper examines defensive tactics and strategies from the German defense in depth that emerged from World War I to the American Active Defense that developed in the Cold War and proposes a new mindset for DIW that draws on these operational concepts from military history.

Influence of fruit drinks with or without lactobacillus Lp299v on the gastrointestinal uptake of paracetamol in man

DEFF Research Database (Denmark)

Akerman, Ulrika; Edvinsson, Lars

2009-01-01

BACKGROUND: Clinical observations have revealed that patients throw up undigested paracetamol tablets several hours following intake of rosehip drink with Lp299v (Proviva). The purpose of this study was to demonstrate if this translates into altered plasma levels of paracetamol in nineteen healthy...... subjects consuming 200 ml of water, Rose hip drink or Proviva together with 1.5 gram of paracetamol. FINDINGS: The concentration of paracetamol in plasma increased rapidly when the paracetamol-containing tablets were consumed together with water and after 30 minutes a median level of 90 mumol/l was reached...... (a 95% confidence interval of 57,161). The corresponding 30 minutes values of paracetamol levels in the presence of rosehip with or without Lp299v were 0 mumol/l (95% confidence intervals contain only zero for both rosehip treatments). There were significant differences in AUC, maximal paracetamol...

Tendencies of development of defensive-industrial complex of lead nations of the world

Directory of Open Access Journals (Sweden)

O. F. Salnikova

2014-11-01

Full Text Available In the article the analysis of development of defensive-industrial complex of lead nations of the world is conducted , namely the United States of America and countries-participants of European Union and NATO. Also in the the article control system of the defensive-industrial policy of the USA is schematically represented. The analysed materials gave an opportunity to draw conclusion, that guidance of military industrial concerns of the USA managed clearly to define acceptable strategies of restructuring and successfully to realize them, integrating new enterprises with the use of front-rank methods of organizational management that became the basic engine of development of defensive industry of the USA. To the number of basic progress of defensive-industrial complex of lead nations-participants of NATO and EU trends it is possible to take the following: creation of the large defensive-industrial integrated structures on development and production of modern armament and military technique on national, transnational and transatlantic levels; rapprochement of military and civil sectors of economy; large corporations go across from mass to the «flexible» production, due to what it is possible to arrive at high efficiency of production of weapons and military equipment even at small series; through diminishing of volumes of assignations on the purchase of defensive products and considerable complication of the modern systems of armament, some leading defensive firms-contractors began to work from the production of armament and military technique to scientific research-and-developments.

U.S. National Defense Acquisition and Budgetary Policy in an International Perspective

Science.gov (United States)

2011-12-03

arsenal. London, UK: Sphere. (Original work published 1981). Kalinina, N., & Kozyulin, V. (2010, Winter). Russian defense industry: Feet of clay ...Mirages over the Andes: Peru , France, the United States, and military jet procurement in the 1960s. The Pacific Historical Review, 71(2), 269–300

International Dynamics of U.S. National Defense Acquisition and Budgetary Policy

Science.gov (United States)

2012-04-30

2010, Winter). Russian defense industry: Feet of clay . Security Index, 1(90), 31–46. Kan, S. (2002). CRS report for Congress—Taiwan: Major U.S...military (pp. 1–44). Carlisle, PA: U.S. Army Strategic Studies Institute. Le Roy, F. (2002, May). Mirages over the Andes: Peru , France, the United States

L_p- and S_{p,q}^rB-discrepancy of (order 2) digital nets

OpenAIRE

Markhasin, Lev

2014-01-01

Dick proved that all order $2$ digital nets satisfy optimal upper bounds of the $L_2$-discrepancy. We give an alternative proof for this fact using Haar bases. Furthermore, we prove that all digital nets satisfy optimal upper bounds of the $S_{p,q}^r B$-discrepancy for a certain parameter range and enlarge that range for order $2$ digitals nets. $L_p$-, $S_{p,q}^r F$- and $S_p^r H$-discrepancy is considered as well.

32 CFR 516.54 - Witnesses for the United States.

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Witnesses for the United States. 516.54 Section..., Travel, and Expenses of Witnesses § 516.54 Witnesses for the United States. (a) Status of witness. A military member authorized to appear as a witness for the United States, including those authorized to...

32 CFR 150.21 - Appeals by the United States.

Science.gov (United States)

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Appeals by the United States. 150.21 Section 150... the United States. (a) Restricted filing. Only a representative of the government designated by the Judge Advocate General of the respective service may file an appeal by the United States under Article...

Integrating theory and data to create an online self-management programme for adults with type 2 diabetes: HeLP-Diabetes

Directory of Open Access Journals (Sweden)

Kingshuk Pal

2015-10-01

This protocol demonstrates a multi-disciplinary approach to combining evidence from multiple sources to create ’HeLP-Diabetes’: a theory and evidence based online self-management intervention for adults with type 2 diabetes.

75 FR 65462 - Renewal of Department of Defense Federal Advisory Committee; Department of Defense Military...

Science.gov (United States)

2010-10-25

... Committee; Department of Defense Military Family Readiness Council AGENCY: Department of Defense (DoD... renewing the charter for the Department of Defense Military Family Readiness Council (hereafter referred to... requirements for the support of military family readiness by the Department of Defense; and (c) evaluate and...

76 FR 77580 - Contemporary Healthcare Senior Lien Fund I, LP; Notice Seeking Exemption Under Section 312 of the...

Science.gov (United States)

2011-12-13

... closing costs and for working capital purposes. The financing is brought within the purview of Sec. 107... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0649] Contemporary Healthcare Senior Lien Fund I, LP; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of...

78 FR 57444 - Eagle Fund III-A, L.P.; Notice Seeking Exemption Under the Small Business Investment Act...

Science.gov (United States)

2013-09-18

... the Small Business Investment Act of 1958, as amended (the ``Act''), in connection with the financing..., Financings which Constitute Conflicts of Interest, of the Small Business Administration (``SBA'') Rules and... SMALL BUSINESS ADMINISTRATION [License No. 07/07-0117] Eagle Fund III-A, L.P.; Notice Seeking...

DETERMINATION OF LEVEL OF FOOD ADDITIVES IN Labisia pumila (LP) BEVERAGES CONSUMED IN KUANTAN, MALAYSIA

OpenAIRE

Iwansyah, Ade Chandra; Yusoff, Masithah Mohammad; Kormin, Faridah

2013-01-01

The content levels of several food additives (gallic acid, benzoic acid and caffeine) in commercial Labisia pumila (LP) beverage samples in Kuantan, Malaysia were determined by high performances liquid chromatography (HPLC). These analytical measurements were undertaken primarily to assess the compliance of content levels of the investigated food additives and their daily intake doses with permissible levels. The results obtained from this study indicated that the average levels of GA, caffei...

China and ballistic missile defense: 1955 to 2002 and beyond

Energy Technology Data Exchange (ETDEWEB)

Brad, Roberts

2004-07-01

China's opposition to U.S. ballistic missile defense was forcefully articulated officially and unofficially between 1991 and 2001. Vociferous opposition gave way to near silence following U.S. ABM Treaty withdrawal, raising a question about precisely whether and how China will respond to future U.S. deployments in both the political and military-operational realms. To gauge likely future responses, it is useful to put the experience of the 1991-2001 period into historical context. China's attitudes toward BMD have passed through a series of distinct phases since the beginning of the nuclear era, as China has been concerned alternately with the problems of strategic defense by both the Soviet Union and United States (and others) around its periphery. Throughout this era it has also pursued its own strategic defense capabilities. There are important elements of continuity in China's attitudes concerns about the viability of its own force and about strategic stability. These suggest the likelihood of significant responses to U.S. BMD even in the absence of sharp rhetoric. (author)

China and ballistic missile defense: 1955 to 2002 and beyond

International Nuclear Information System (INIS)

Brad, Roberts

2004-01-01

China's opposition to U.S. ballistic missile defense was forcefully articulated officially and unofficially between 1991 and 2001. Vociferous opposition gave way to near silence following U.S. ABM Treaty withdrawal, raising a question about precisely whether and how China will respond to future U.S. deployments in both the political and military-operational realms. To gauge likely future responses, it is useful to put the experience of the 1991-2001 period into historical context. China's attitudes toward BMD have passed through a series of distinct phases since the beginning of the nuclear era, as China has been concerned alternately with the problems of strategic defense by both the Soviet Union and United States (and others) around its periphery. Throughout this era it has also pursued its own strategic defense capabilities. There are important elements of continuity in China's attitudes concerns about the viability of its own force and about strategic stability. These suggest the likelihood of significant responses to U.S. BMD even in the absence of sharp rhetoric. (author)

Bedre ældrepleje - ved hjælp af Marte Meo metoden

DEFF Research Database (Denmark)

Meyer, Helle; Schjoldager, Helle Højbo

Projektet (forløb efteråret 2008 - foråret 2009) havde til formål at give personalet ved boformer for borgere med demens indsigt i og redskaber til at kommunikere med borgeren på en for begge parter anerkendende måde - ved hjælp af Marte Meo metoden. Det konkluderes at implementering af Marte Meo...... metoden har medført, at personalet har udviklet deres samspil og kommunikation med borgerne på en måde, der synes at fremme borgerens trivsel, værdighed og livsglæde og dermed bidrage til en øget livskvalitet. En række faktorer der henholdsvis fremmer og hæmmer implementeringen af Marte Meo metoden...

Current Obstacles to Fully Preparing Title 10 Forces for Homeland Defense and Civil Support

National Research Council Canada - National Science Library

Campbell, James S

2008-01-01

.... During a crisis, the President and Secretary of Defense could authorize use of Title 10 forces. However, this "just in time" approach does not allow for the units assigned the opportunity to be fully trained to respond...

MicroRNA-Mediated Gene Silencing in Plant Defense and Viral Counter-Defense

Directory of Open Access Journals (Sweden)

Sheng-Rui Liu

2017-09-01

Full Text Available MicroRNAs (miRNAs are non-coding RNAs of approximately 20–24 nucleotides in length that serve as central regulators of eukaryotic gene expression by targeting mRNAs for cleavage or translational repression. In plants, miRNAs are associated with numerous regulatory pathways in growth and development processes, and defensive responses in plant–pathogen interactions. Recently, significant progress has been made in understanding miRNA-mediated gene silencing and how viruses counter this defense mechanism. Here, we summarize the current knowledge and recent advances in understanding the roles of miRNAs involved in the plant defense against viruses and viral counter-defense. We also document the application of miRNAs in plant antiviral defense. This review discusses the current understanding of the mechanisms of miRNA-mediated gene silencing and provides insights on the never-ending arms race between plants and viruses.

Recognizing Plant Defense Priming.

Science.gov (United States)

Martinez-Medina, Ainhoa; Flors, Victor; Heil, Martin; Mauch-Mani, Brigitte; Pieterse, Corné M J; Pozo, Maria J; Ton, Jurriaan; van Dam, Nicole M; Conrath, Uwe

2016-10-01

Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in plants. Copyright © 2016 Elsevier Ltd. All rights reserved.

Defense Islands in Bacterial and Archaeal Genomes and Prediction of Novel Defense Systems ▿†‡

Science.gov (United States)

Makarova, Kira S.; Wolf, Yuri I.; Snir, Sagi; Koonin, Eugene V.

2011-01-01

The arms race between cellular life forms and viruses is a major driving force of evolution. A substantial fraction of bacterial and archaeal genomes is dedicated to antivirus defense. We analyzed the distribution of defense genes and typical mobilome components (such as viral and transposon genes) in bacterial and archaeal genomes and demonstrated statistically significant clustering of antivirus defense systems and mobile genes and elements in genomic islands. The defense islands are enriched in putative operons and contain numerous overrepresented gene families. A detailed sequence analysis of the proteins encoded by genes in these families shows that many of them are diverged variants of known defense system components, whereas others show features, such as characteristic operonic organization, that are suggestive of novel defense systems. Thus, genomic islands provide abundant material for the experimental study of bacterial and archaeal antivirus defense. Except for the CRISPR-Cas systems, different classes of defense systems, in particular toxin-antitoxin and restriction-modification systems, show nonrandom clustering in defense islands. It remains unclear to what extent these associations reflect functional cooperation between different defense systems and to what extent the islands are genomic “sinks” that accumulate diverse nonessential genes, particularly those acquired via horizontal gene transfer. The characteristics of defense islands resemble those of mobilome islands. Defense and mobilome genes are nonrandomly associated in islands, suggesting nonadaptive evolution of the islands via a preferential attachment-like mechanism underpinned by the addictive properties of defense systems such as toxins-antitoxins and an important role of horizontal mobility in the evolution of these islands. PMID:21908672

Remote viewing of melter interior Defense Waste Processing Facility

International Nuclear Information System (INIS)

Heckendorn, F.M. II.

1986-01-01

A remote system has been developed and demonstrated for continuous reviewing of the interior of a glass melter, which is used to vitrify highly radioactive waste. The system is currently being implemented with the Defense Waste Processing Facility (DWPF) now under construction at the Savannah River Plant (SRP). The environment in which the borescope/TV unit is implemented combines high temperature, high ionizing radiation, low light, spattering, deposition, and remote maintenance

Malpractice liability and defensive medicine: a national survey of neurosurgeons.

Directory of Open Access Journals (Sweden)

Brian V Nahed

Full Text Available BACKGROUND: Concern over rising healthcare expenditures has led to increased scrutiny of medical practices. As medical liability and malpractice risk rise to crisis levels, the medical-legal environment has contributed to the practice of defensive medicine as practitioners attempt to mitigate liability risk. High-risk specialties, such as neurosurgery, are particularly affected and neurosurgeons have altered their practices to lessen medical-legal risk. We present the first national survey of American neurosurgeons' perceptions of malpractice liability and defensive medicine practices. METHODS: A validated, 51-question online-survey was sent to 3344 practicing U.S. neurosurgeon members of the American Association of Neurological Surgeons, which represents 76% of neurosurgeons in academic and private practices. RESULTS: A total of 1028 surveys were completed (31% response rate by neurosurgeons representing diverse sub-specialty practices. Respondents engaged in defensive medicine practices by ordering additional imaging studies (72%, laboratory tests (67%, referring patients to consultants (66%, or prescribing medications (40%. Malpractice premiums were considered a "major or extreme" burden by 64% of respondents which resulted in 45% of respondents eliminating high-risk procedures from their practice due to liability concerns. CONCLUSIONS: Concerns and perceptions about medical liability lead practitioners to practice defensive medicine. As a result, diagnostic testing, consultations and imaging studies are ordered to satisfy a perceived legal risk, resulting in higher healthcare expenditures. To minimize malpractice risk, some neurosurgeons have eliminated high-risk procedures. Left unchecked, concerns over medical liability will further defensive medicine practices, limit patient access to care, and increase the cost of healthcare delivery in the United States.

Malpractice liability and defensive medicine: a national survey of neurosurgeons.

Science.gov (United States)

Nahed, Brian V; Babu, Maya A; Smith, Timothy R; Heary, Robert F

2012-01-01

Concern over rising healthcare expenditures has led to increased scrutiny of medical practices. As medical liability and malpractice risk rise to crisis levels, the medical-legal environment has contributed to the practice of defensive medicine as practitioners attempt to mitigate liability risk. High-risk specialties, such as neurosurgery, are particularly affected and neurosurgeons have altered their practices to lessen medical-legal risk. We present the first national survey of American neurosurgeons' perceptions of malpractice liability and defensive medicine practices. A validated, 51-question online-survey was sent to 3344 practicing U.S. neurosurgeon members of the American Association of Neurological Surgeons, which represents 76% of neurosurgeons in academic and private practices. A total of 1028 surveys were completed (31% response rate) by neurosurgeons representing diverse sub-specialty practices. Respondents engaged in defensive medicine practices by ordering additional imaging studies (72%), laboratory tests (67%), referring patients to consultants (66%), or prescribing medications (40%). Malpractice premiums were considered a "major or extreme" burden by 64% of respondents which resulted in 45% of respondents eliminating high-risk procedures from their practice due to liability concerns. Concerns and perceptions about medical liability lead practitioners to practice defensive medicine. As a result, diagnostic testing, consultations and imaging studies are ordered to satisfy a perceived legal risk, resulting in higher healthcare expenditures. To minimize malpractice risk, some neurosurgeons have eliminated high-risk procedures. Left unchecked, concerns over medical liability will further defensive medicine practices, limit patient access to care, and increase the cost of healthcare delivery in the United States.

78 FR 57444 - Eagle Fund III, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts...

Science.gov (United States)

2013-09-18

... Small Business Investment Act of 1958, as amended (the ``Act''), in connection with the financing of a... SMALL BUSINESS ADMINISTRATION [License No. 07/07-0116] Eagle Fund III, L.P.; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Eagle...

Antipredator defenses predict diversification rates

Science.gov (United States)

Arbuckle, Kevin; Speed, Michael P.

2015-01-01

The “escape-and-radiate” hypothesis predicts that antipredator defenses facilitate adaptive radiations by enabling escape from constraints of predation, diversified habitat use, and subsequently speciation. Animals have evolved diverse strategies to reduce the direct costs of predation, including cryptic coloration and behavior, chemical defenses, mimicry, and advertisement of unprofitability (conspicuous warning coloration). Whereas the survival consequences of these alternative defenses for individuals are well-studied, little attention has been given to the macroevolutionary consequences of alternative forms of defense. Here we show, using amphibians as the first, to our knowledge, large-scale empirical test in animals, that there are important macroevolutionary consequences of alternative defenses. However, the escape-and-radiate hypothesis does not adequately describe them, due to its exclusive focus on speciation. We examined how rates of speciation and extinction vary across defensive traits throughout amphibians. Lineages that use chemical defenses show higher rates of speciation as predicted by escape-and-radiate but also show higher rates of extinction compared with those without chemical defense. The effect of chemical defense is a net reduction in diversification compared with lineages without chemical defense. In contrast, acquisition of conspicuous coloration (often used as warning signals or in mimicry) is associated with heightened speciation rates but unchanged extinction rates. We conclude that predictions based on the escape-and-radiate hypothesis must incorporate the effect of traits on both speciation and extinction, which is rarely considered in such studies. Our results also suggest that knowledge of defensive traits could have a bearing on the predictability of extinction, perhaps especially important in globally threatened taxa such as amphibians. PMID:26483488

LP-LPA: A link influence-based label propagation algorithm for discovering community structures in networks

Science.gov (United States)

Berahmand, Kamal; Bouyer, Asgarali

2018-03-01

Community detection is an essential approach for analyzing the structural and functional properties of complex networks. Although many community detection algorithms have been recently presented, most of them are weak and limited in different ways. Label Propagation Algorithm (LPA) is a well-known and efficient community detection technique which is characterized by the merits of nearly-linear running time and easy implementation. However, LPA has some significant problems such as instability, randomness, and monster community detection. In this paper, an algorithm, namely node’s label influence policy for label propagation algorithm (LP-LPA) was proposed for detecting efficient community structures. LP-LPA measures link strength value for edges and nodes’ label influence value for nodes in a new label propagation strategy with preference on link strength and for initial nodes selection, avoid of random behavior in tiebreak states, and efficient updating order and rule update. These procedures can sort out the randomness issue in an original LPA and stabilize the discovered communities in all runs of the same network. Experiments on synthetic networks and a wide range of real-world social networks indicated that the proposed method achieves significant accuracy and high stability. Indeed, it can obviously solve monster community problem with regard to detecting communities in networks.

Planetary Defense

Science.gov (United States)

2016-05-01

4 Abstract Planetary defense against asteroids should be a major concern for every government in the world . Millions of asteroids and...helps make Planetary Defense viable because defending the Earth against asteroids benefits from all the above technologies. So if our planet security...information about their physical characteristics so we can employ the right strategies. It is a crucial difference if asteroids are made up of metal

Ensuring a Strong U.S. Defense for the Future: The National Defense Panel Review of the 2014 Quadrennial Defense Review

Science.gov (United States)

2014-07-31

territorial disputes with China. We note recent moves to station U.S. forces in Darwin , the plan to station a number of Littoral Combat Ships in Singapore...Under Secretary of Defense, Comptroller (C) Charles “Chuck” Hagel Secretary of Defense Mara Karlin Principal Director for Strategy, Policy (P...Support Staff to the Panel Charles Arnold George Sinks U.S. Government Liaison Officers Lori Abele Chief of Staff, Deputy Under Secretary of Defense

Technologies for distributed defense

Science.gov (United States)

Seiders, Barbara; Rybka, Anthony

2002-07-01

For Americans, the nature of warfare changed on September 11, 2001. Our national security henceforth will require distributed defense. One extreme of distributed defense is represented by fully deployed military troops responding to a threat from a hostile nation state. At the other extreme is a country of 'citizen soldiers', with families and communities securing their common defense through heightened awareness, engagement as good neighbors, and local support of and cooperation with local law enforcement, emergency and health care providers. Technologies - for information exploitation, biological agent detection, health care surveillance, and security - will be critical to ensuring success in distributed defense.

DEFENSE-ATTACK INTERACTION OVER OPTIMALLY DESIGNED DEFENSE SYSTEMS VIA GAMES AND RELIABILITY

Directory of Open Access Journals (Sweden)

Isis Didier Lins

2014-05-01

Full Text Available This paper analyzes defense systems taking into account the strategic interactions between two rational agents; one of them is interested in designing a defense system against purposeful attacks of the other. The interaction is characterized by a sequential game with perfect and complete information. Reliability plays a fundamental role in both defining agents' actions and in measuring performance of the defense system for which a series-parallel configuration is set up by the defender. The attacker, in turn, focuses on only one defense subsystem in order to maximize her efficiency in attacking. An algorithm involving backward induction is developed to determine the equilibrium paths of the game. Application examples are also provided.

Comparison of a lightweight polypropylene mesh (Optilene® LP) and a large-pore knitted PTFE mesh (GORE® INFINIT® mesh)--Biocompatibility in a standardized endoscopic extraperitoneal hernia model.

Science.gov (United States)

Jacob, Dietmar A; Schug-Pass, Christine; Sommerer, Florian; Tannapfel, Andrea; Lippert, Hans; Köckerling, Ferdinand

2012-02-01

The use of a mesh with good biocompatibility properties is of decisive importance for the avoidance of recurrences and chronic pain in endoscopic hernia repair surgery. As we know from numerous experiments and clinical experience, large-pore, lightweight polypropylene meshes possess the best biocompatibility. However, large-pore meshes of different polymers may be used as well and might be an alternative solution. Utilizing a totally extraperitoneal technique in an established animal model, 20 domestic pigs were implanted with either a lightweight large-pore polypropylene (PP) mesh (Optilene® LP) or a medium-weight large-pore knitted polytetrafluorethylene (PTFE) mesh (GORE® INFINIT® mesh). After 94 days, the pigs were sacrificed and postmortem diagnostic laparoscopy was performed, followed by explantation of the specimens for macroscopic, histological and immunohistochemical evaluation. The mean mesh shrinkage rate was 14.2% for Optilene® LP vs. 24.7% for INFINIT® mesh (p = 0.017). The partial volume of the inflammatory cells was 11.2% for Optilene® LP vs. 13.9% for INFINIT (n.s.). CD68 was significantly higher for INFINIT (11.8% vs. 5.6%, p = 0.007). The markers of cell turnover, namely Ki67 and the apoptotic index, were comparable at 6.4% vs. 12.4% (n.s.) and 1.6% vs. 2.0% (n.s.). In the extracellular matrix, TGF-β was 35.4% for Optilene® LP and 31.0% for INFINIT® (n.s.). Collagen I (pos/300 μm) deposits were 117.8 and 114.9, respectively. In our experimental examinations, Optilene® LP and INFINIT® showed a comparable biocompatibility in terms of chronic inflammatory reaction; however, the shrinkage rate was significantly higher for INFINIT® after 3 months. The higher shrinkage rate of INFINIT® should be taken into account when choosing the mesh size for an adequate hernia overlap.

Economics of defense high level waste management in the United States

International Nuclear Information System (INIS)

McDonell, W.R.

1987-01-01

Life-cycle costs of defense waste disposal, as presented in the foregoing sections, are summarized. Expressed as incremental costs per canister of waste deposited in a Federal geologic repository and per gallon of decontaminated salt solution immobilized in onsite concrete vaults, the tabulated values provide a measure of waste management costs relatively independent of the inventories of waste processed. Total values are about $350,000 per glass waste canister processed and $4.68 per gallon of decontaminated salt immobilized. These costs do not generally include contributions of fixed charges, such as capital costs, except in the case of transport and repository charges for which the quantities of waste handled determine allocation of fixed costs included in the fee assessments. 14 refs., 2 figs., 3 tabs

RELAP5/MOD2 post-test calculation of the OECD LOFT experiment LP-SB-2

International Nuclear Information System (INIS)

Perez, J.; Mendizabal, R.

1992-04-01

This document presents the analysis of the OECD LOFT LP-SB-2 Experiment performed by the Consejo de Seguridad Nuclear of Spain working group making use of RELAP5/MOD2 in the frame of the Spanish LOFT Project. LB-SB-2 experiment studies the effect of a delayed pump trip in a small break LOCA scenario with a 3-inch equivalent diameter break in the hot leg of a commercial PWR

Back to the Future: Integrated Air and Missile Defense in the Pacific

Science.gov (United States)

2015-02-01

US assets with those of our allies and partners, we have optimized our defense design, pre- venting the waste of precious interceptors. The Pacific...Good Offense: Attack Operations Power projection is, and always will be, th e bread and butter of the US Air Force. Only the United States can

FOREIGN RELATIONS: Kwajalein Atoll Is the Key U.S. Defense Interest in Two Micronesian Nations

National Research Council Canada - National Science Library

2002-01-01

...) and the Republic of the Marshall Islands (RMI). The Compact provided for the continuation of a defense arrangement that has connected the United States and these Pacific islands since the end of World War II...

The defense waste processing facility: the final processing step for defense high-level waste disposal

International Nuclear Information System (INIS)

Cowan, S.P.; Sprecher, W.M.; Walton, R.D.

1983-01-01

The policy of the U.S. Department of Energy is to pursue an aggressive and credible waste management program that advocates final disposal of government generated (defense) high-level nuclear wastes in a manner consistent with environmental, health, and safety responsibilities and requirements. The Defense Waste Processing Facility (DWPF) is an essential component of the Department's program. It is the first project undertaken in the United States to immobilize government generated high-level nuclear wastes for geologic disposal. The DWPF will be built at the Department's Savannah River Plant near Aiken, South Carolina. When construction is complete in 1989, the DWPF will begin processing the high-level waste at the Savannah River Plant into a borosilicate glass form, a highly insoluble and non-dispersable product, in easily handled canisters. The immobilized waste will be stored on site followed by transportation to and disposal in a Federal repository. The focus of this paper is on the DWPF. The paper discusses issues which justify the project, summarizes its technical attributes, analyzes relevant environmental and insitutional factors, describes the management approach followed in transforming technical and other concepts into concrete and steel, and concludes with observations about the future role of the facility

Housekeeping category corrective action unit work plan

International Nuclear Information System (INIS)

1996-08-01

The purpose of this Corrective Action Unit (CAU) Work Plan is to provide a strategy to be used by the US Department of Energy Nevada Operations Office (DOE/NV), the US Department of Defense (DoD) Defense Special Weapons Agency (DSWA) (formerly the Defense Nuclear Agency), and contractor personnel for conducting corrective actions at the Nevada Test Site (NTS) and Nevada off-site locations including the Tonopah Test Range (TTR), the Project Shoal Area, and the Central Nevada Test Area. This Work Plan applies to housekeeping category CAUs already listed in the Federal Facility Agreement and Consent Order (FFACO) Appendices (FFACO, 1996) as well as newly identified Corrective Action Sites (CASs) that will follow the housekeeping process

77 FR 70429 - Gulf South Pipeline Company, LP; Notice of Intent To Prepare an Environmental Assessment for the...

Science.gov (United States)

2012-11-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-21-000] Gulf South Pipeline Company, LP; Notice of Intent To Prepare an Environmental Assessment for the Planned Southeast Market Expansion Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meetings The staff of the Federal Energy...

76 FR 36914 - Astoria Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas...

Science.gov (United States)

2011-06-23

... Generating Company, L.P., NRG Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC... Power Marketing LLC, Arthur Kill Power LLC, Astoria Gas Turbine Power LLC, Dunkirk Power LLC, Huntley... when a document is added to a subscribed docket(s). For assistance with any FERC Online service, please...

75 FR 45178 - Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2010-08-02

..., Financings which Constitute Conflicts of Interest of the Small Business Administration (``SBA'') Rules and... contemplated to fund the ongoing operating needs of the business. The financing is brought within the purview... SMALL BUSINESS ADMINISTRATION Escalate Capital Partners SBIC I, L.P.; Notice Seeking Exemption...

Strategic planning for minimizing CO2 emissions using LP model based on forecasted energy demand by PSO Algorithm and ANN

Energy Technology Data Exchange (ETDEWEB)

Yousefi, M.; Omid, M.; Rafiee, Sh. [Department of Agricultural Machinery Engineering, University of Tehran, Karaj (Iran, Islamic Republic of); Ghaderi, S. F. [Department of Industrial Engineering, University of Tehran, Tehran (Iran, Islamic Republic of)

2013-07-01

Iran's primary energy consumption (PEC) was modeled as a linear function of five socioeconomic and meteorological explanatory variables using particle swarm optimization (PSO) and artificial neural networks (ANNs) techniques. Results revealed that ANN outperforms PSO model to predict test data. However, PSO technique is simple and provided us with a closed form expression to forecast PEC. Energy demand was forecasted by PSO and ANN using represented scenario. Finally, adapting about 10% renewable energy revealed that based on the developed linear programming (LP) model under minimum CO2 emissions, Iran will emit about 2520 million metric tons CO2 in 2025. The LP model indicated that maximum possible development of hydropower, geothermal and wind energy resources will satisfy the aim of minimization of CO2 emissions. Therefore, the main strategic policy in order to reduce CO2 emissions would be exploitation of these resources.

Infimal Convolution Regularisation Functionals of BV and Lp Spaces

KAUST Repository

Burger, Martin

2016-02-03

We study a general class of infimal convolution type regularisation functionals suitable for applications in image processing. These functionals incorporate a combination of the total variation seminorm and Lp norms. A unified well-posedness analysis is presented and a detailed study of the one-dimensional model is performed, by computing exact solutions for the corresponding denoising problem and the case p=2. Furthermore, the dependency of the regularisation properties of this infimal convolution approach to the choice of p is studied. It turns out that in the case p=2 this regulariser is equivalent to the Huber-type variant of total variation regularisation. We provide numerical examples for image decomposition as well as for image denoising. We show that our model is capable of eliminating the staircasing effect, a well-known disadvantage of total variation regularisation. Moreover as p increases we obtain almost piecewise affine reconstructions, leading also to a better preservation of hat-like structures.

The US-Russia missile defense dialogue as a factor of the Russian defense policy

OpenAIRE

Dmitry Suslov

2013-01-01

To a big extent the Russian defense policy and, as a consequence, development of the Russian defense industrial complex, is determined by the prospects of the US missile defense policy and fate of the US-Russia negotiations in this area. As a cooperative solution seems improbable in the observable future, Russia plans to develop certain response measures of military nature, including creation of a new heavy ICBM, and to create its own missile defense by 2015. However, this policy does not see...

War or Peace? How the Subjective Perception of Great Power Interdependence Shapes Preemptive Defensive Aggression.

Science.gov (United States)

Jing, Yiming; Gries, Peter H; Li, Yang; Stivers, Adam W; Mifune, Nobuhiro; Kuhlman, D M; Bai, Liying

2017-01-01

Why do great powers with benign intentions end up fighting each other in wars they do not seek? We utilize an incentivized, two-person "Preemptive Strike Game" (PSG) to explore how the subjective perception of great power interdependence shapes defensive aggression against persons from rival great powers. In Study 1, college students from the United States ( N = 115), China ( N = 106), and Japan ( N = 99) made PSG decisions facing each other. This natural experiment revealed that Chinese and Japanese participants (a) made more preemptive attacks against each other and Americans than against their compatriots, and that (b) greater preexisting perceptions of bilateral competition increased intergroup attack rates. In Study 2, adult Americans ( N = 127) watched real CNN expert interviews portraying United States-China economic interdependence as more positive or negative. This randomized experiment revealed that the more positive portrayal reduced preemptive American strikes against Chinese (but not Japanese), while the more negative portrayal amplified American anger about China's rise, increasing preemptive attacks against Chinese. We also found, however, that preemptive strikes were primarily defensive and not offensive. Interventions to reduce defensive aggression and promote great power peace are discussed.

War or Peace? How the Subjective Perception of Great Power Interdependence Shapes Preemptive Defensive Aggression

Directory of Open Access Journals (Sweden)

Yiming Jing

2017-06-01

Full Text Available Why do great powers with benign intentions end up fighting each other in wars they do not seek? We utilize an incentivized, two-person “Preemptive Strike Game” (PSG to explore how the subjective perception of great power interdependence shapes defensive aggression against persons from rival great powers. In Study 1, college students from the United States (N = 115, China (N = 106, and Japan (N = 99 made PSG decisions facing each other. This natural experiment revealed that Chinese and Japanese participants (a made more preemptive attacks against each other and Americans than against their compatriots, and that (b greater preexisting perceptions of bilateral competition increased intergroup attack rates. In Study 2, adult Americans (N = 127 watched real CNN expert interviews portraying United States–China economic interdependence as more positive or negative. This randomized experiment revealed that the more positive portrayal reduced preemptive American strikes against Chinese (but not Japanese, while the more negative portrayal amplified American anger about China’s rise, increasing preemptive attacks against Chinese. We also found, however, that preemptive strikes were primarily defensive and not offensive. Interventions to reduce defensive aggression and promote great power peace are discussed.

Defense Agency Travel Payments at Defense Finance and Accounting Service Indianapolis Center

National Research Council Canada - National Science Library

1997-01-01

The audit objective was to assess the effectiveness of Defense Finance and Accounting Service Indianapolis Center management controls over payments to Defense agency personnel for temporary duty and local travel...

Examining the Islamic stock market efficiency: Evidence from nonlinear ESTAR unit root tests

Directory of Open Access Journals (Sweden)

Rahmat Heru Setianto

2015-04-01

Full Text Available This paper empirically examines the efficient market hypothesis (EMH in the Islamic stock market namely Jakarta Islamic Index by emphasizing on the random walk behavior and nonlinearity. In the first step, we employ Brock et al. (1996 test to examine the presence of nonlinear behavior in Jakarta Islamic Index. The evidence of nonlinear behavior in the indices, motivate us to use nonlinear ESTAR unit root test procedure recently developed by Kapetanios et al. (2003 and Kruse (2011. The nonlinear unit root test procedure fail to rejects the null hypothesis of unit root for the indices, suggesting that Jakarta Islamic Index characterized by random walk process supporting the theory of efficient market hypothesis. In addition, Lumsdaine and Papel (LP test identified significant structural breaks in the index series.

Expeditionary Air Base Defense: Historical Cases and Modern Implications

Science.gov (United States)

2017-06-01

203. 50 As violence in Iraq’s urban areas surged in 2006, IDF attacks against Balad Air Base reached their peak, with approximately 475...defense operations when appropriate, but it is not a singular solution for quickly or completely reducing violence in the area of air bases. The case of...forces “drawing from the units available.”3 This is appropriate for small combat outposts ( COP ) or forward operating bases (FOB) in lower threat

SELF-DEFENSE IN KARABAKH CONFLICT?

Directory of Open Access Journals (Sweden)

Saeed Bagheri

2015-01-01

Full Text Available Use of force is one of the principles of international law which has been banned by the UN Charter and modern constitutions. However, since the enforcement of the UN Charter, self-defense has become the preferred excuse for states to justify their use of force. But applying self-defense requires some conditions. Immediacy is one of the important conditions of self-defense. Immediacy defined as the time span between armed attacks and reaction to it, is the main discourse. This condition requires self defense immediately after the armed conflict or during a rational time span since its occurance.In this respect, the emerging Karabakh Conflict between Armenia and Azerbaijan in the 1990s is important. After Armenia’s armed attacks, Azerbaijan has acted within the scope of legitimate self-defense. But in accordance with UN Security Council cease-fire resolution Azerbaijan has suspended its self-defense actions. However, today, still twenty percent of Azerbaijani territory is still under Armenian occupation. Accordingly, after a long time the validity of Azerbaijan’s right to legitimate self-defense is still subject to arguments.In this article, by comparing two different approaches (strict and board interpretation approaches on the temporal link between the measures of self-defense and the armed attacks (immediacy, the temporal link between the self-defense countermeasures of Azerbaijan and armed attacks by Armenia in Karabakh Conflict will be examined.

Effect of dissolved oxygen on SCC of LP turbine steel

International Nuclear Information System (INIS)

Maeng, W. Y.; Lee, J. H.; Kim, W. C.

2002-01-01

Slow Strain Rate Tests (SSRT) were carried out to investigate the effect of dissolved oxygen on Stress Corrosion Cracking (SCC) susceptibility of 3.5NiCrMoV steels used in discs of Low-Pressure (LP) steam turbines in electric power generating plants. The influence of dissolved oxygen on cracking in water was studied; for this purpose, specimens were strained to fracture at 150 .deg. C in water environments with various amounts of dissolved oxygen. The maximum elongation of the turbine steel decreased with increasing dissolved oxygen. Dissolved oxygen significantly affected the SCC susceptibility of turbine steel in water. The increase of the SCC susceptibility of the turbine steel in a higher dissolved oxygen environment is due to the non protectiveness of the oxide layer of the turbine steel surface and the increase of corrosion current

76 FR 54758 - Alliance Pipeline L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned...

Science.gov (United States)

2011-09-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF11-7-000] Alliance Pipeline L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned Tioga Lateral Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting The staff of the Federal Energy Regulatory Commission (FERC or...

77 FR 13117 - Excelerate Energy L.P.; Notice of Intent To Prepare an Environmental Impact Statement for the...

Science.gov (United States)

2012-03-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-4-000] Excelerate Energy L.P.; Notice of Intent To Prepare an Environmental Impact Statement for the Planned Aguirre Offshore Gasport Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meetings The staff of the Federal Energy Regulatory...

77 FR 59601 - Dominion Cove Point LNG, LP; Notice of Intent To Prepare an Environmental Assessment for the...

Science.gov (United States)

2012-09-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF12-16-000] Dominion Cove Point LNG, LP; Notice of Intent To Prepare an Environmental Assessment for the Planned Cove Point Liquefaction Project, Request for Comments on Environmental Issues, Notice of On- Site Environmental Review, and Notice of Public Scoping Meetings The...

75 FR 56089 - Equitrans, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned Sunrise...

Science.gov (United States)

2010-09-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PF10-19-000] Equitrans, L.P.; Notice of Intent To Prepare an Environmental Assessment for the Planned Sunrise Pipeline Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting September 3, 2010. The staff of the Federal Energy Regulatory...

75 FR 56093 - Eagle Rock Desoto Pipeline, LP; Notice of Motion for Extension of Rate Case Filing Deadline

Science.gov (United States)

2010-09-15

... pipelines to extend the cycle for such reviews from three to five years.\\1\\ Therefore, Eagle Rock requests... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR09-1-002] Eagle Rock... notice that on September 8, 2010, Eagle Rock Desoto Pipeline, L.P. (Eagle Rock) filed a request to extend...

Beyond the cold war nuclear legacy: offense-defense and the role of nuclear deterrence

International Nuclear Information System (INIS)

Dunn, L.A.

2001-01-01

Since the September 11 terrorist attacks on the World Trade Center and the Pentagon, the defense community of the United States focused overwhelmingly on countering the threat of global terrorism. This focus rightly reflects the danger of additional terrorist attacks against the American homeland, including conceivably even with nuclear weapons or radiological devices. At the same time, the December, 2001 announcement of the U.S. decision to withdraw from the 1972 Anti-Ballistic Missile (ABM) Treaty after the six month waiting period serves as a reminder that there still is considerable other outstanding 'defense business' confronting the United States and its European allies. In particular, it is increasingly essential to re-craft the Cold War nuclear weapons legacy, not only in its own right but because doing so can also have important payoffs for the success of the U.S.-led global anti-terrorist campaign. The following paper first describes some of the main features of the Cold War nuclear legacy. It then sketches a number of different schools of thought or camps that exist within the U.S. defense community in answer to the question, 'what next with nuclear weaponry?' In light of those contending positions, it then sets out a possible way ahead - moving to re-craft U.S. strategic dealings with Russia toward a non-adversary relationship, to avoid a new Cold War with China, and to put in place the right mix of offensive and defensive, nuclear and non-nuclear capabilities to contain 21. century proliferation dangers. (author)

Beyond the cold war nuclear legacy: offense-defense and the role of nuclear deterrence

Energy Technology Data Exchange (ETDEWEB)

Dunn, L.A

2001-07-01

Since the September 11 terrorist attacks on the World Trade Center and the Pentagon, the defense community of the United States focused overwhelmingly on countering the threat of global terrorism. This focus rightly reflects the danger of additional terrorist attacks against the American homeland, including conceivably even with nuclear weapons or radiological devices. At the same time, the December, 2001 announcement of the U.S. decision to withdraw from the 1972 Anti-Ballistic Missile (ABM) Treaty after the six month waiting period serves as a reminder that there still is considerable other outstanding 'defense business' confronting the United States and its European allies. In particular, it is increasingly essential to re-craft the Cold War nuclear weapons legacy, not only in its own right but because doing so can also have important payoffs for the success of the U.S.-led global anti-terrorist campaign. The following paper first describes some of the main features of the Cold War nuclear legacy. It then sketches a number of different schools of thought or camps that exist within the U.S. defense community in answer to the question, 'what next with nuclear weaponry?' In light of those contending positions, it then sets out a possible way ahead - moving to re-craft U.S. strategic dealings with Russia toward a non-adversary relationship, to avoid a new Cold War with China, and to put in place the right mix of offensive and defensive, nuclear and non-nuclear capabilities to contain 21. century proliferation dangers. (author)

Beyond the cold war nuclear legacy: offense-defense and the role of nuclear deterrence

Energy Technology Data Exchange (ETDEWEB)

Dunn, L A

2001-07-01

Since the September 11 terrorist attacks on the World Trade Center and the Pentagon, the defense community of the United States focused overwhelmingly on countering the threat of global terrorism. This focus rightly reflects the danger of additional terrorist attacks against the American homeland, including conceivably even with nuclear weapons or radiological devices. At the same time, the December, 2001 announcement of the U.S. decision to withdraw from the 1972 Anti-Ballistic Missile (ABM) Treaty after the six month waiting period serves as a reminder that there still is considerable other outstanding 'defense business' confronting the United States and its European allies. In particular, it is increasingly essential to re-craft the Cold War nuclear weapons legacy, not only in its own right but because doing so can also have important payoffs for the success of the U.S.-led global anti-terrorist campaign. The following paper first describes some of the main features of the Cold War nuclear legacy. It then sketches a number of different schools of thought or camps that exist within the U.S. defense community in answer to the question, 'what next with nuclear weaponry?' In light of those contending positions, it then sets out a possible way ahead - moving to re-craft U.S. strategic dealings with Russia toward a non-adversary relationship, to avoid a new Cold War with China, and to put in place the right mix of offensive and defensive, nuclear and non-nuclear capabilities to contain 21. century proliferation dangers. (author)

The pathogenesis of H7N8 low and highly pathogenic avian influenza viruses from the United States 2016 outbreak in chickens, turkeys and mallards

Science.gov (United States)

Pantin-Jackwood, Mary J.; Stephens, Christopher B.; Bertran, Kateri; Swayne, David E.

2017-01-01

In January 2016, a combined outbreak of highly pathogenic (HP) avian influenza virus (AIV) and low pathogenicity (LP) AIV occurred in commercial turkeys in the state of Indiana, United States. Genetically, the viruses were highly similar, belonged to the North American wild bird lineage, and had not been previously detected in poultry. In order to understand the pathobiology of the H7N8 LPAIV and HPAIV, infectivity, transmission and pathogenicity studies were conducted in chickens, turkeys, and mallards. Among the three species the lowest mean infectious dose for both the LP and HP phenotype was for turkeys, and also disease from the LPAIV was only observed with turkeys. Furthermore, although the HPAIV was lethal for both chickens and turkeys, clinical signs caused by the HPAIV isolate differed between the two species; neurological signs were only observed in turkeys. Mallards could be infected with and transmit both viruses to contacts, but neither caused clinical disease. Interestingly, with all three species, the mean infectious dose of the HP isolate was at least ten times lower than that of the LP isolate. This study corroborates the high susceptibility of turkeys to AIV as well as a pathobiology that is different from chickens. Further, this study demonstrates that mallards can be asymptomatically infected with HP and LP AIV from gallinaceous poultry and may not just be involved in transmitting AIV to them. PMID:28481948

Defense Treaty Inspection Readiness Program

International Nuclear Information System (INIS)

Cronin, J.J.; Kohen, M.D.; Rivers, J.D.

1996-01-01

The Defense Treaty Inspection Readiness Program (DTIRP) was established by the Department of Defense in 1990 to assist defense facilities in preparing for treaty verification activities. Led by the On-Site Inspection Agency (OSIA), an element of the Department of Defense, DTIRP''s membership includes representatives from other Department of Defense agencies, the Department of Energy (DOE), the Central Intelligence Agency, the Federal Bureau of Investigation, the Department of Commerce, and others. The Office of Safeguards and Security has a significant interest in this program, due to the number of national defense facilities within its purview that are candidates for future inspections. As a result, the Office of Safeguards and Security has taken a very active role in DTIRP. This paper discusses the Office of Safeguards and Security''s increasing involvement in various elements of the DTIRP, ranging from facility assessments to training development and implementation

78 FR 73915 - Solutions Capital I, L.P., License No. 03/03-0247; Notice Seeking Exemption Under Section 312 of...

Science.gov (United States)

2013-12-09

..., Financings which Constitute Conflicts of Interest of the Small Business Administration (``SBA'') Rules and... Business Holdings, Inc., 30775 Barrington, Suite 100, Madison Heights, MI 48071 (``Dorsey''). The financing... SMALL BUSINESS ADMINISTRATION Solutions Capital I, L.P., License No. 03/03-0247; Notice Seeking...

Defense Business Transformation

Science.gov (United States)

2009-12-01

Defense Business Transformation by Jacques S. Gansler and William Lucyshyn The Center for Technology and National...REPORT TYPE 3. DATES COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE Defense Business Transformation 5a. CONTRACT NUMBER 5b. GRANT NUMBER...vii Part One: DoD Business Transformation

78 FR 2313 - CapitalSpring SBIC, L.P., License No. 09/79-0454, Notice Seeking Exemption Under the Small...

Science.gov (United States)

2013-01-10

... Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of a small... SMALL BUSINESS ADMINISTRATION CapitalSpring SBIC, L.P., License No. 09/79-0454, Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Capital...

76 FR 59767 - Plexus Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment...

Science.gov (United States)

2011-09-27

..., Financings which Constitute Conflicts of Interest of the Small Business Administration (``SBA'') Rules and Regulations (13 CFR 107.730). Plexus II, L.P., proposes to provide debt security financing to Project Empire... the Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing...

Strategic planning for minimizing CO2 emissions using LP model based on forecasted energy demand by PSO Algorithm and ANN

Energy Technology Data Exchange (ETDEWEB)

Yousefi, M.; Omid, M.; Rafiee, Sh. [Department of Agricultural Machinery Engineering, University of Tehran, Karaj (Iran, Islamic Republic of); Ghaderi, S.F. [Department of Industrial Engineering, University of Tehran, Tehran (Iran, Islamic Republic of)

2013-07-01

Iran's primary energy consumption (PEC) was modeled as a linear function of five socioeconomic and meteorological explanatory variables using particle swarm optimization (PSO) and artificial neural networks (ANNs) techniques. Results revealed that ANN outperforms PSO model to predict test data. However, PSO technique is simple and provided us with a closed form expression to forecast PEC. Energy demand was forecasted by PSO and ANN using represented scenario. Finally, adapting about 10% renewable energy revealed that based on the developed linear programming (LP) model under minimum CO2 emissions, Iran will emit about 2520 million metric tons CO2 in 2025. The LP model indicated that maximum possible development of hydropower, geothermal and wind energy resources will satisfy the aim of minimization of CO2 emissions. Therefore, the main strategic policy in order to reduce CO2 emissions would be exploitation of these resources.

VOCATIONAL AND PATRIOTIC EDUCATION OF STUDENTS OF DEFENSE SPECIALTIES AT A TECHNICAL UNIVERSITY

Directory of Open Access Journals (Sweden)

N. P. Ustinova

2016-01-01

Full Text Available The aim of the publication is an experimental research of patriotic qualities of students – future engineers of the defense industry. Methods. The study is conducted with the use of system-based analysis methods, teacher modeling, observation, interviews, pedagogical testing, and questionnaires. Diagnosis and evaluation of personal qualities of students are carried out using morphological life values test (modified by I. G. Senin, and questionnaire «The need for achieving the goal» (modified by Y. M. Orlov. The reliability of the results is granted by the use of statistical processing of empirical methods. Results. The average empirical values have been obtained concerning the level of professional and patriotic education of students of defence specialties at technical universities. It has been shown that targeted educational activities carried out on the basis of the identified organizational and pedagogical conditions, contributes to the level of professional and patriotic education of students of defense specialties at a Technical University.Scientific novelty. In relation to students – future professionals of defense industry, the concept of «professional – patriotic education» is clarified, which appears to be an integrative quality of a person, including cognitive, emotion-andvalue component and rational-activity components. The organizational and pedagogical conditions of vocational patriotic education of students of defense specialties are identified; the conditions are united into two groups: the creation of professional-oriented educative environment and creating the opportunities for active participation of students in educational and professional activities. Practical significance. Designed criterion-evaluation units are used to evaluate the current level of professional and patriotic education of students. Identified set of organizational and pedagogical conditions has been implemented in the process of patriotic education

Self-Defense in Karabakh Conflict?

Directory of Open Access Journals (Sweden)

Saeed Bagheri

2015-01-01

Full Text Available Use of force is one of the principles of international law that has been banned by the UN Charter and modern constitutions. However, since the enforcement of the UN Charter, self-defense has become the preferred excuse for states to justify their use of force. Applying self-defense, however, requires some conditions. Immediacy is one of the important conditions of self-defense. This is defined as the timeframe between armed attacks and reaction to it. This situation requires self-defense immediately after the armed conflict or during a reasonable timeframe since its occurance.In this respect, emerging Karabakh Conflict between Armenia and Azerbaijan in the 1990s is important. In this article, by comparing two different approaches (strict and board interpretation of the temporal link between the measures of self-defense and the armed attacks (immediacy, the temporal link between the self-defense countermeasures of Azerbaijan and attacks by Armenia in Karabakh Conflict will be examined.

Organizing Defense Logistics: What Strategic Structures Should Exist for the Defense Supply Chain

National Research Council Canada - National Science Library

Maddox, Edward D

2005-01-01

.... The primary research question of this study was: What strategic organizational structures should exist within the Department of Defense to facilitate further integration of the defense supply chain...

The role of fantasies, countertransference, and psychological defenses in patient violence.

Science.gov (United States)

Dubin, W R

1989-12-01

Over the past decade the management of aggression on psychiatric units has generally focused on pharmacologic and physical interventions rather than on psychodynamic concerns. The author reviews the dynamics of violence and discusses how clinical staff's fantasies, countertransferences, and psychological defenses may interact to trigger patient aggression. Interventions that address these issues with staff include developing a cohesive treatment team in which clinical staff can express their feelings without the need to explore the psychodynamic underpinnings, having clinical leaders maintain a strong presence on the unit to serve as role models, and providing regular inservice training.

Effects of Dietary Lycopene Supplementation on Plasma Lipid Profile, Lipid Peroxidation and Antioxidant Defense System in Feedlot Bamei Lamb.

Science.gov (United States)

Jiang, Hongqin; Wang, Zhenzhen; Ma, Yong; Qu, Yanghua; Lu, Xiaonan; Luo, Hailing

2015-07-01

Lycopene, a red non-provitamin A carotenoid, mainly presenting in tomato and tomato byproducts, has the highest antioxidant activity among carotenoids because of its high number of conjugated double bonds. The objective of this study was to investigate the effect of lycopene supplementation in the diet on plasma lipid profile, lipid peroxidation and antioxidant defense system in feedlot lamb. Twenty-eight Bamei male lambs (90 days old) were divided into four groups and fed a basal diet (LP0, 40:60 roughage: concentrate) or the basal diet supplemented with 50, 100, and 200 mg/kg lycopene. After 120 days of feeding, all lambs were slaughtered and sampled. Dietary lycopene supplementation significantly reduced the levels of plasma total cholesterol (p0.05). The levels of TG (pCAT, pCAT (p<0.05, linearly) and SOD (p<0.001, linearly). Therefore, it was concluded that lycopene supplementation improved the antioxidant status of the lamb and optimized the plasma lipid profile, the dosage of 200 mg lycopene/kg feed might be desirable for growing lambs to prevent environment stress and maintain normal physiological metabolism.

Economic Sanctions as a Factor of Modernizing of Russian Defense Industry Complex

Directory of Open Access Journals (Sweden)

Rustem M. Nureev

2017-09-01

Full Text Available The article is devoted to the analysis of the defense-industrial complex (DIC of Russia in the conditions of economic sanctions. And although the center was the oil and gas industry, as well as the banking sector, economic sanctions against Russia affected the DCI. They touched first of all on such large Russian defense concerns as air defense "Almaz- Antey", "Sirius", "Stankoinstroment", "Kalashnikov", "Tula Arms Factory", NGO "Oriental Complexes", as well as "Dobrolyte". The prohibition of debt financing has affected such major enterprises of the defense industry as "Uralvagonzavod", "Oboronprom", "United Aircraft Corporation". The article shows, in general, the favorable impact of sanctions on the industry. At the end of 2016, Russia took the second place in world arms exports with a share of 23%, the US became the leader – their share was 33%. But the structure of the share capital in the defense industry companies is completely different if we compare these two countries: in the US, private companies dominate the market, in Russia – the largest enterprises are owned by the state. In the course of the analysis, it turned out that Russian defense industry enterprises are unprofitable or unprofitable, they do not have stability in financial performance, since they are highly dependent on government spending. To improve the current situation in this sector, it is advisable for the state to modernize the military-industrial complex companies in order to enhance the role of market mechanisms that will stimulate R & D, as under modern conditions of competition in any market, innovations represent an exclusive advantage for enterprise prosperity.

No-hardware-signature cybersecurity-crypto-module: a resilient cyber defense agent

Science.gov (United States)

Zaghloul, A. R. M.; Zaghloul, Y. A.

2014-06-01

We present an optical cybersecurity-crypto-module as a resilient cyber defense agent. It has no hardware signature since it is bitstream reconfigurable, where single hardware architecture functions as any selected device of all possible ones of the same number of inputs. For a two-input digital device, a 4-digit bitstream of 0s and 1s determines which device, of a total of 16 devices, the hardware performs as. Accordingly, the hardware itself is not physically reconfigured, but its performance is. Such a defense agent allows the attack to take place, rendering it harmless. On the other hand, if the system is already infected with malware sending out information, the defense agent allows the information to go out, rendering it meaningless. The hardware architecture is immune to side attacks since such an attack would reveal information on the attack itself and not on the hardware. This cyber defense agent can be used to secure a point-to-point, point-to-multipoint, a whole network, and/or a single entity in the cyberspace. Therefore, ensuring trust between cyber resources. It can provide secure communication in an insecure network. We provide the hardware design and explain how it works. Scalability of the design is briefly discussed. (Protected by United States Patents No.: US 8,004,734; US 8,325,404; and other National Patents worldwide.)

WLPGA: the World LP Gas Association in Berlin; the WLPGA 2004 Action Plan; change of direction; WLPGA: la WLPGA a Berlin; le Plan d'Actions 2004 de la WLPGA; reorientation

Energy Technology Data Exchange (ETDEWEB)

Anon.

2004-07-15

After Bangkok in 2002 and Santiago de Chile in 2003, the World Forum of the World LP Gas Association (WLPGA) is returning to Europe for two and a half days of exhibition and two days of conferences from 29 September to 1 October at the Hotel lnterContinental in Berlin. As a Europe of 25 is now a reality, the Forum will obviously focus on this situation and the prospects for LP Gas in the new group without, however, neglecting the global issues which are why it exists. The WLPGA has a new Managing Director, James Rockall, since 2 August. He previously held the post of Director of Market Development for the Association from july 2003. The 2004 action plan of the World LP Gas Association forms part of the strategic decisions taken at the end of 2001 for the period 2002-2006. Its structure remains identical to that of the previous plan but with the continuous rise in 'the good industrial practices', there is one programme more than in 2003. There is particular emphasis on the programme for developing LP Gas markets in rural areas, at the core of which is the LP Gas Rural Energy Challenge launched 2 years ago in the framework of a partnership with the UNPD. Moreover, the WLPGA contribution to the preparation of the World Energy Outlook of the LEA is testimony to the reinforcement of relations with this agency, and the Association also took part in the World Energy Congress in Sydney. The other programmes are also progressing: GAIN, GLOTEC, without forgetting the preparation of the annual forum and the services provided directly to WLPGA members. Having decided on a change of direction in his career, Emmanuel Chantelot left the WLPGA and the LP Gas industry on 31 July 2004. He should be attending the Members' Dinner at the Berlin Forum. Emmanuel Chantelot has led the World Association for just over 7 years as Managing Director. (authors)

The Few and the Proud: Veterans in Congress on Defense Issues

Science.gov (United States)

2013-04-15

on her responsibility to her constituents and district, freshman Representative Tulsi Gabbard (D-HI, post-9/11) tied defense cuts in spending on the...narrative supporting their position. 33 problems within the United States. Freshman Representative Gabbard believes, “We have decimated Al Qaeda...89 Freshman Representative Gabbard , on the other hand, credibly indicated she understood the current conflict because she was a post-9/11 veteran

Defense Weather Satellites: DOD Faces Acquisition Challenges for Addressing Capability Needs

Science.gov (United States)

2016-07-07

and compare the operational effectiveness and life cycle costs of potential solutions. This testimony is based on a report GAO issued in March...Technology, House of Representatives For Release on Delivery Expected at 10 a.m. ET Thursday, July 7, 2016 GAO-16-769T United States...Environment, Committee on Science, Space, and Technology, House of Representatives July 2016 DEFENSE WEATHER SATELLITES DOD Faces Acquisition

Strategic Defense Initiative Overview

National Research Council Canada - National Science Library

1990-01-01

... to Third World and other nations. I will then discuss the scope of the SDI effort, the evolving strategic defense system architectures and theater defense, our compliancy with the ABM Treaty, technology spinoffs resulting from SDI...

INSTITUTIONAL BASIS OF MANAGEMENT AND EVALUATION OF UKRAINIAN DEFENSE LANDS

Directory of Open Access Journals (Sweden)

Garazhа Y.P

2017-02-01

Full Text Available The management and evaluation of defense land was revealed in the article. Specific institution is the military institutе in the institutional framework for defense land. A special regime and zoning, evaluation, payment and exclusion conditions were established for these lands. The market economy has changed the land-property relations in the country. Lands for defense used only in the framework that established the state. Recently there was a tendency of land release this subcategory. This has led to their misuse, belonging to other owners. The research problem consists of the setting clear boundaries of defense land and legal regulation mechanisms of land relations. Public ownership rights applies only to the defense lands. They are located only in the state ownership. The subject is the state that implements ownership (right to possess, use and dispose of the lands of Defense. It ensures the defense of the country and territory for military sites, airfields, parts, ammunition depots. Functional use of defense land is divided into public (military schools, socio-cultural (health centers, recreation centers, industrial (military and industrial objects, residential (cantonment, commercial (commissary, special (military installations, transport ( carpark, bridges, engineering (antennas, radars, storage (defense deport. The land for military unit were given for permanent use with the justification of the project design documentation sizes. The military part of the land for permanent use with the justification sizes by the project design documentation. Safety, security and other areas are created around military and other defense installations. There are restricted areas, prohibited areas. They have a special regime. Reform of the Armed Forces of Ukraine, the State Special Transport Service leads to the release of land and real estate. Reform of the Armed Forces of Ukraine, the State Special Transport Service leads to the release of land and real

Summary Report on the Audit of Defense Logistics Agency 1995 Defense Base Realignment and Closure Data Collection Process.

Science.gov (United States)

1995-06-19

VXW-ÄVAVKVX’AWXW/XVXV:*: OFFICE OF THE INSPECTOR GENERAL SUMMARY REPORT ON THE AUDIT OF DEFENSE LOGISTICS AGENCY 1995 DEFENSE BASE REALIGNMENT...FOR DIRECTOR, DEFENSE LOGISTICS AGENCY SUBJECT: Summary Report on the Audit of Defense Logistics Agency 1995 Defense Base Realignment and Closure...the data that DLA provides to support recommendations for the 1995 Commission. The specific objective for the audits was to determine whether the

The Security and Defense of America's Ports: An Assessment of Coast Guard and Navy Roles, Capabilities and Synchronization

National Research Council Canada - National Science Library

Richardt, Timothy P

2006-01-01

.... The United States must thus act to increase security for seaborne commerce and create depth of enforcement through the assets of the Department of Homeland Security and the Department of Defense...

Towards a European Defense Identity Compatible with NATO

Directory of Open Access Journals (Sweden)

Rafael Estrella

1997-12-01

Full Text Available The European Security and Defense Identity (ESDI is a common but not defined goal, due to disagreements among Europeans on its political content. Reasons to explain this are related to the resistance to the idea of a European defense authority, fears of German hegemony, and the conviction that Europe is uncapable of defending herselfwithout the assistance of the United States. Estrella states that, with the end of the Cold War, some arguments opposing ESDI lost weight. However, the evolution and restructuring of NATO is not the product of European initiative, but rather an element of the U.S.strategy in Europe. Moreover, while the U.S. has a global strategy, Europe has not yet defined its security interests neither globally nor regionally. The author reviews the steps undertaken by NATO and the WEU towards further collaboration and the development of a European identity. He wonders whether there is enough political will either in Europe or the U.S. to overcome archaic views on trans-atlantic relations and narrow concepts about the future of Europe.

Safety issues at the defense production reactors

International Nuclear Information System (INIS)

1987-01-01

The United States produces plutonium and tritium for use in nuclear weapons at the defense production reactors endash the N Reactor in Washington and the Savannah River reactors in South Carolina. This report reaches general conclusions about the management of those reactors and highlights a number of safety and technical issues that should be resolved. The report provides an assessment of the safety management, safety review, and safety methodology employed by the Department of Energy and the private contractors who operate the reactors for the federal government. The report is necessarily based on a limited review of the defense production reactors. It does not address whether any of the reactors are ''safe,'' because such an analysis would involve a determination of acceptable risk endash a matter of obvious importance, but one that was beyond the purview of the committee. It also does not address whether the safety of the production reactors is comparable to that of commercial nuclear power stations, because even this narrower question extended beyond the charge to the committee and would have involved detailed analyses that the committee could not undertake

Department of Defense perspective

International Nuclear Information System (INIS)

Devine, R.

1985-01-01

This paper examines radiation instrumentation from the Department of Defense perspective. Radiation survey instruments and calibration, or RADIAC, as it is called in the services, while administratively falling under the Assistant Secretary of Defense for Atomic Energy, has generally been managed at a lower level. The Naval Electronics Systems Command and Army Signal Corp are the two principles in the Department of Defense for RADIAC. The actions of the services are coordinated through the tri-service RADIAC working group, which meets about every year and a half. Several points from this organization are highlighted

75 FR 12230 - Black Oak Energy, L.L.C., EPIC Merchant Energy, LP, SESCO Enterprises, LLC v. PJM Interconnection...

Science.gov (United States)

2010-03-15

... Energy, L.L.C., EPIC Merchant Energy, LP, SESCO Enterprises, LLC v. PJM Interconnection, L.L.C.; Notice of Filing March 8, 2010. Take notice that on March 1, 2010, PJM Interconnection, L.L.C. filed a..., Order Accepting Compliance filing issued in this proceeding, Black Oak Energy, L.L.C., et al. v. PJM...

77 FR 76586 - GC SBIC IV, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act...

Science.gov (United States)

2012-12-28

... Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of two... SMALL BUSINESS ADMINISTRATION [License No. 02/02-0644] GC SBIC IV, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of Interest Notice is hereby given...

78 FR 69516 - DeltaPoint Capital IV, L.P.; License No. 02/02-0662; Notice Seeking Exemption Under the Small...

Science.gov (United States)

2013-11-19

... Business Investment Act of 1958, as amended (``the Act''), in connection with the financing of a small... SMALL BUSINESS ADMINISTRATION DeltaPoint Capital IV, L.P.; License No. 02/02-0662; Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest Notice is hereby given that Delta...

The pathogenesis of H7N8 low and highly pathogenic avian influenza viruses from the United States 2016 outbreak in chickens, turkeys and mallards.

Directory of Open Access Journals (Sweden)

Mary J Pantin-Jackwood

Full Text Available In January 2016, a combined outbreak of highly pathogenic (HP avian influenza virus (AIV and low pathogenicity (LP AIV occurred in commercial turkeys in the state of Indiana, United States. Genetically, the viruses were highly similar, belonged to the North American wild bird lineage, and had not been previously detected in poultry. In order to understand the pathobiology of the H7N8 LPAIV and HPAIV, infectivity, transmission and pathogenicity studies were conducted in chickens, turkeys, and mallards. Among the three species the lowest mean infectious dose for both the LP and HP phenotype was for turkeys, and also disease from the LPAIV was only observed with turkeys. Furthermore, although the HPAIV was lethal for both chickens and turkeys, clinical signs caused by the HPAIV isolate differed between the two species; neurological signs were only observed in turkeys. Mallards could be infected with and transmit both viruses to contacts, but neither caused clinical disease. Interestingly, with all three species, the mean infectious dose of the HP isolate was at least ten times lower than that of the LP isolate. This study corroborates the high susceptibility of turkeys to AIV as well as a pathobiology that is different from chickens. Further, this study demonstrates that mallards can be asymptomatically infected with HP and LP AIV from gallinaceous poultry and may not just be involved in transmitting AIV to them.

Staphylococcus aureus lipoproteins trigger human corneal epithelial innate response through toll-like receptor-2.

Science.gov (United States)

Li, Qiong; Kumar, Ashok; Gui, Jian-Fang; Yu, Fu-Shin X

2008-05-01

Bacterial lipoproteins (LP) are a family of cell wall components found in a wide variety of bacteria. In this study, we characterized the response of HUCL, a telomerase-immortalized human corneal epithelial cell (HCEC) line, to LP isolated from Staphylococcus (S) aureus. S. aureus LP (saLP) prepared by Triton X-114 extraction stimulated the activation of NF-kappaB, JNK, and P38 signaling pathways in HUCL cells. The extracts failed to stimulate NF-kappaB activation in HUCL cells after lipoprotein lipase treatment and in cell lines expressing TLR4 or TLR9, but not TLR2, indicating lipoprotein nature of the extracts. saLP induced the up-regulation of a variety of inflammatory cytokines and chemokines (IL-6, IL-8, ICAM-1), antimicrobial molecules (hBD-2, LL-37, and iNOS), and homeostasis genes (Mn-SOD) at both the mRNA level and protein level. Similar inflammatory response to saLP was also observed in primarily cultured HCECs using the production of IL-6 as readout. Moreover, TLR2 neutralizing antibody blocked the saLP-induced secretion of IL-6, IL-8 and hBD2 in HUCL cells. Our findings suggest that saLP activates TLR2 and triggers innate immune response in the cornea to S. aureus infection via production of proinflammatory cytokines and defense molecules.

Acquisition Planning at the Defense Communications Agency.

Science.gov (United States)

1984-04-01

guidelines for interaction are developed under the leadership of DCA agencywide integrators with the participation of personnel from DCA, the Services...Communications System DCSO - Defense Communications System Organizatin . DDN - Defense Data Network DEC - Decision Making DG - Defense Guidance DIA - Defense

Deterrence and the Future of U.S.-GCC Defense Cooperation: A Strategic Dialogue Event

Science.gov (United States)

2015-07-01

be taken to help incorporate ballistic missile defense systems into the security architecture of Gulf states. Finally, the United States should...American’s copanelist, the Kuwaiti political scientist, added that the GCC has not fully embraced the idea. “It’s an Egyptian -led project,” he said. “Cairo

Defense Finance and Accounting Service Administration of Unit Costs

National Research Council Canada - National Science Library

Lay, F

1996-01-01

...) of products or outputs produced. Audit Objectives. We conducted this part of our audit to find out whether unit costs for goods and services provided by DFAS were determined in accordance with DoD policies and based on actual costs incurred...

78 FR 32293 - VPC SBIC I, LP, License No. 05/05 0308; Notice Seeking Exemption Under Section 312 of the Small...

Science.gov (United States)

2013-05-29

... the Small Business Investment Act of 1958, as amended (``the Act''), in connection with the financing..., Financings which Constitute Conflicts of Interest of the Small Business Administration (``SBA'') Rules and... SMALL BUSINESS ADMINISTRATION VPC SBIC I, LP, License No. 05/05 0308; Notice Seeking Exemption...

76 FR 55720 - BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the...

Science.gov (United States)

2011-09-08

... approval under section 312 of the Act and Section 107.730 (a)(4), Provide Financing to a Small Business to... SMALL BUSINESS ADMINISTRATION [License No. 04/04-0311] BB&T Capital Partners Mezzanine Fund II, L.P.; Notice Seeking Exemption Under Section 312 of the Small Business Investment Act, Conflicts of...

75 FR 32640 - Defense Federal Acquisition Regulation Supplement; Finland- Public Interest Exception to the Buy...

Science.gov (United States)

2010-06-08

... procurement memorandum of understanding (RDP MOU) between the government of Finland and the Government of the United States has been in effect since 1991. The governments have negotiated and concluded a new RDP MOU... Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System. 0 Therefore, 48...

COP21: defense stakes

International Nuclear Information System (INIS)

Coldefy, Alain; Hulot, Nicolas; Aichi, Leila; Tertrais, Bruno; Paillard, Christophe-Alexandre; Piodi, Jerome; Regnier, Serge; Volpi, Jean-Luc; Descleves, Emmanuel; Garcin, Thierry; Granholm, Niklas; Wedin, Lars; Pouvreau, Ana; Henninger, Laurent

2015-01-01

The 21. Conference of the Parties (COP21) from the UN Framework Convention took place in Paris between November 30 and December 11, 2015. The challenge is to reach a universal agreement of fight against global warming and to control the carbon footprint of human activities. This topic is in the core of the Defense Ministry preoccupations. This special dossier takes stock of the question of defense issues linked with global warming. The dossier comprises 13 papers dealing with: 1 - COP21: defense stakes (Coldefy, A.); 2 - Warfare climate, a chance for peace (Hulot, N.); 3 - COP21 and defense (Aichi, L.); 4 - A war climate? (Tertrais, B.); 5 - Challenges the World has to face in the 21. century (Paillard, C.A.); 6 - Desertification: a time bomb in the heart of Sahel (Piodi, J.); 7 - The infrastructure department of defense in the fight against climate disturbance (Regnier, S.); 8 - Fight against global warming, a chance for the forces? (Volpi, J.L.); 9 - Sea and sustainable development (Descleves, E.); 10 - Rationales of Arctic's surrounding powers (Garcin, T.); 11 - Arctic: strategic stake (Granholm, N.; Wedin, L.); 12 - Strategic impact of Turkey's new energy choices (Pouvreau, A.); 13 - Climate and war: a brief historical outlook (Henninger, L.)

Is flood defense changing in nature? Shifts in the flood defense strategy in six European countries

Directory of Open Access Journals (Sweden)

Mathilde Gralepois

2016-12-01

Full Text Available In many countries, flood defense has historically formed the core of flood risk management but this strategy is now evolving with the changing approach to risk management. This paper focuses on the neglected analysis of institutional changes within the flood defense strategies formulated and implemented in six European countries (Belgium, England, France, the Netherlands, Poland, and Sweden. The evolutions within the defense strategy over the last 30 years have been analyzed with the help of three mainstream institutional theories: a policy dynamics-oriented framework, a structure-oriented institutional theory on path dependency, and a policy actors-oriented analysis called the advocacy coalitions framework. We characterize the stability and evolution of the trends that affect the defense strategy in the six countries through four dimensions of a policy arrangement approach: actors, rules, resources, and discourses. We ask whether the strategy itself is changing radically, i.e., toward a discontinuous situation, and whether the processes of change are more incremental or radical. Our findings indicate that in the European countries studied, the position of defense strategy is continuous, as the classical role of flood defense remains dominant. With changing approaches to risk, integrated risk management, climate change, urban growth, participation in governance, and socioeconomic challenges, the flood defense strategy is increasingly under pressure to change. However, these changes can be defined as part of an adaptation of the defense strategy rather than as a real change in the nature of flood risk management.

33 CFR 328.5 - Changes in limits of waters of the United States.

Science.gov (United States)

2010-07-01

... OF THE ARMY, DEPARTMENT OF DEFENSE DEFINITION OF WATERS OF THE UNITED STATES § 328.5 Changes in... drainage may remove an area from waters of the United States. Man-made changes may affect the limits of...

Annual Report to the Congress, Fiscal Year 1988, Caspar W. Weinberger, Secretary of Defense. Executive Summary.

Science.gov (United States)

1988-01-01

these threats are not merely isolated occurrences. Terrorism is increasingly transnacional and state-supported. Drug trafficking is increasingly...deter- rence and defense through their presence abroad and by our capability to deploy them from the continental United States (CONUS) to crisis areas

THE CONCEPT OF "SMART DEFENSE" IN THE CONTEXT OF AN EFFICIENT DEFENSE PLANNING

Directory of Open Access Journals (Sweden)

Teodor FRUNZETI

2012-01-01

Full Text Available The international security environment is currently undergoing a series of fundamental changes becoming increasingly complex. Consequently, international actors need to find innovative ways to manage security and defense. The global financial and economic crisis has had a strong impact on military budgets, making it necessary for states and regional and international organizations concerned with such issues to streamline their defense planning and the more so because, in addition to the already consecrated risks and security threats, there are also new challenges. The concepts of “pooling and sharing” and “smart defense” have become, in this context, increasingly popular generating new initiatives in defense planning. However, despite some successes in this regard and their presentation as ideal solutions for managing defense in the current context, these concepts involve a number of difficulties to overcome that sometimes may translate into strategic political military and even economic disadvantages.

47 CFR 90.411 - Civil defense communications.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Civil defense communications. 90.411 Section 90... PRIVATE LAND MOBILE RADIO SERVICES Operating Requirements § 90.411 Civil defense communications. The... necessary for the implementation of civil defense activities assigned such station by local civil defense...

Features of lipid metabolism disturbances in patients with rheumatoid arthritis

Directory of Open Access Journals (Sweden)

A E Sizikov

2009-01-01

Full Text Available Objective. To characterize specters of common and modified lipoproteins (LP in serum of pts with rheumatoid arthritis (RA according to age and sex and compare with healthy donors (with normal lipid level. Material and methods. 103 pts with RA (88 female and 15 male aged 21 to 69 years were included. Specters of common and modified LP in serum and plasma were evaluated with small-angle x-ray scattering. Results. Low level of intermediate density lipoproteins (IDLP subfractions and very low density lipoproteins (VLDLP as well as high level of low density lipoproteins (LDLP30 was revealed in pts with RA. Mean level of LP modification was about 60%. High density lipoproteins (HDLP subfraction was least and IDLP subfraction – most susceptible to modification. LP modification level increased due to LDLP and VLDLP fractions. This level had a tendency to increase with age because of elevation of atherogenic LP part. Mean values of common LP did not differ between sex and age groups of pts with RA. Unexpectedly low (in comparison with normal lipid content level of LP modification of the whole fraction of HDLP was the feature of modified LP specter in pts with RA. Conclusion. Level of common and modified LP in blood plasma and serum of RA pts is connected with general state of lipid metabolism and immune defense factors balance. Low level of VLDLP cholesterol and high level of LDLP cholesterol as well as high degree of LP of these fractions modification may be probably considered as markers of RA activity.

DCT-based cyber defense techniques

Science.gov (United States)

Amsalem, Yaron; Puzanov, Anton; Bedinerman, Anton; Kutcher, Maxim; Hadar, Ofer

2015-09-01

With the increasing popularity of video streaming services and multimedia sharing via social networks, there is a need to protect the multimedia from malicious use. An attacker may use steganography and watermarking techniques to embed malicious content, in order to attack the end user. Most of the attack algorithms are robust to basic image processing techniques such as filtering, compression, noise addition, etc. Hence, in this article two novel, real-time, defense techniques are proposed: Smart threshold and anomaly correction. Both techniques operate at the DCT domain, and are applicable for JPEG images and H.264 I-Frames. The defense performance was evaluated against a highly robust attack, and the perceptual quality degradation was measured by the well-known PSNR and SSIM quality assessment metrics. A set of defense techniques is suggested for improving the defense efficiency. For the most aggressive attack configuration, the combination of all the defense techniques results in 80% protection against cyber-attacks with PSNR of 25.74 db.

Safety analysis report; packages LP-50 tritium package. (Packaging of fissile and other radioactive materials). Final report

International Nuclear Information System (INIS)

Gates, A.A.; McCarthy, P.G.; Edl, J.W.; Chalfant, G.G.

1975-05-01

Elemental tritium is shipped at low pressure in a stainless steel container (LP-50) surrounded by an aluminum vessel and Celotex insulation at least 4 in. thick in a steel drum. The total weight of the package is 260 lbs maximum. The various components that constitute the package are described and are shown in 7 figures. The safety analysis includes: structural evaluations; thermal evaluations; containment; operating procedures; acceptance tests and maintenance program; and design review

75 FR 42436 - Houston Pipe Line Company LP-Bammel Storage, Docket No. PR10-51-000, et. al.; Notice of Baseline...

Science.gov (United States)

2010-07-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Houston Pipe Line Company LP--Bammel Storage, Docket No. PR10-51- 000, et. al.; Notice of Baseline Filings July 14, 2010. Houston Pipe Line..., 2010, respectively the applicants listed above submitted their baseline filing of its Statement of...

Defense Mechanisms: A Bibliography.

Science.gov (United States)

Pedrini, D. T.; Pedrini, Bonnie C.

This bibliography includes studies of defense mechanisms, in general, and studies of multiple mechanisms. Defense mechanisms, briefly and simply defined, are the unconscious ego defendants against unpleasure, threat, or anxiety. Sigmund Freud deserves the clinical credit for studying many mechanisms and introducing them in professional literature.…

Variation in plant defense suppresses herbivore performance

Science.gov (United States)

Pearse, Ian; Paul, Ryan; Ode, Paul J.

2018-01-01

Defensive variability of crops and natural systems can alter herbivore communities and reduce herbivory. However, it is still unknown how defense variability translates into herbivore suppression. Nonlinear averaging and constraints in physiological tracking (also more generally called time-dependent effects) are the two mechanisms by which defense variability might impact herbivores. We conducted a set of experiments manipulating the mean and variability of a plant defense, showing that defense variability does suppress herbivore performance and that it does so through physiological tracking effects that cannot be explained by nonlinear averaging. While nonlinear averaging predicted higher or the same herbivore performance on a variable defense than on an invariable defense, we show that variability actually decreased herbivore performance and population growth rate. Defense variability reduces herbivore performance in a way that is more than the average of its parts. This is consistent with constraints in physiological matching of detoxification systems for herbivores experiencing variable toxin levels in their diet and represents a more generalizable way of understanding the impacts of variability on herbivory. Increasing defense variability in croplands at a scale encountered by individual herbivores can suppress herbivory, even if that is not anticipated by nonlinear averaging.

Tactile defensiveness and stereotyped behaviors.

Science.gov (United States)

Baranek, G T; Foster, L G; Berkson, G

1997-02-01

This study explores the constructs of stereotyped behaviors (e.g., repetitive motor patterns, object manipulations, behavioral rigidities) and tactile defensiveness as relevant to occupational therapy theory and practice and attempts to test their purported relationships in children with developmental disabilities. Twenty-eight children with developmental disabilities and autism were assessed on eight factors of stereotyped behavior via a questionnaire and by four measures of tactile defensiveness. The subjects' scores from the questionnaire were correlated with their scores on the tactile defensiveness measures to see what, if any, relationship among these behaviors exists. Significant relationships emerged from the data, indicating that subjects with higher levels of tactile defensiveness were also more likely to evidence rigid or inflexible behaviors, repetitive verbalizations, visual stereotypes, and abnormal focused affections that are often associated with autism. No significant association was found between motor and object stereotypes and tactile defensiveness. These relationships could not be explained solely by maturational factors. The results suggest that clinicians should include observations of stereotyped behaviors, particularly behavioral rigidities, in conjunction with assessments of sensory defensiveness because these are related phenomena that may pose unique challenges for children with developmental disabilities and autism. Further study is needed to determine the causal mechanisms responsible for these relationships.

An LP-model to analyse economic and ecological sustainability on Dutch dairy farms: model presentation and application for experimental farm "de Marke"

NARCIS (Netherlands)

Calker, van K.J.; Berentsen, P.B.M.; Boer, de I.J.M.; Giesen, G.W.J.; Huirne, R.B.M.

2004-01-01

Farm level modelling can be used to determine how farm management adjustments and environmental policy affect different sustainability indicators. In this paper indicators were included in a dairy farm LP (linear programming)-model to analyse the effects of environmental policy and management

Mood States Associated with Induced Defensiveness.

Science.gov (United States)

Jaderlund, Natasha Slesnick; Waldron, Holly Barrett

1994-01-01

Compared effects of neutral and defensive mood induction in 70 students reporting conflicted versus nonconflicted families for presence of hostility, aggression, fear, anxiety, and sadness. Found that defensive students from high-conflict families reported stronger negative emotions than did neutral high-conflict and defensive low-conflict…

22 CFR 120.9 - Defense service.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense service. 120.9 Section 120.9 Foreign... Defense service. (a) Defense service means: (1) The furnishing of assistance (including training) to..., educational, or information publications and media of all kinds, training aid, orientation, training exercise...

Defense waste management plan

International Nuclear Information System (INIS)

1983-06-01

Defense high-level waste (HLW) and defense transuranic (TRU) waste are in interim storage at three sites, namely: at the Savannah River Plant, in South Carolina; at the Hanford Reservation, in Washington; and at the Idaho National Engineering Laboratory, in Idaho. Defense TRU waste is also in interim storage at the Oak Ridge National Laboratory, in Tennessee; at the Los Alamos National Laboratory, in New Mexico; and at the Nevada Test Site, in Nevada. (Figure E-2). This document describes a workable approach for the permanent disposal of high-level and transuranic waste from atomic energy defense activities. The plan does not address the disposal of suspect waste which has been conservatively considered to be high-level or transuranic waste but which can be shown to be low-level waste. This material will be processed and disposed of in accordance with low-level waste practices. The primary goal of this program is to utilize or dispose of high-level and transuranic waste routinely, safely, and effectively. This goal will include the disposal of the backlog of stored defense waste. A Reference Plan for each of the sites describes the sequence of steps leading to permanent disposal. No technological breakthroughs are required to implement the reference plan. Not all final decisions concerning the activities described in this document have been made. These decisions will depend on: completion of the National Environmental Policy Act process, authorization and appropriation of funds, agreements with states as appropriate, and in some cases, the results of pilot plant experiments and operational experience. The major elements of the reference plan for permanent disposal of defense high-level and transuranic waste are summarized

The methodological defense of realism scrutinized.

Science.gov (United States)

Wray, K Brad

2015-12-01

I revisit an older defense of scientific realism, the methodological defense, a defense developed by both Popper and Feyerabend. The methodological defense of realism concerns the attitude of scientists, not philosophers of science. The methodological defense is as follows: a commitment to realism leads scientists to pursue the truth, which in turn is apt to put them in a better position to get at the truth. In contrast, anti-realists lack the tenacity required to develop a theory to its fullest. As a consequence, they are less likely to get at the truth. My aim is to show that the methodological defense is flawed. I argue that a commitment to realism does not always benefit science, and that there is reason to believe that a research community with both realists and anti-realists in it may be better suited to advancing science. A case study of the Copernican Revolution in astronomy supports this claim. Copyright © 2015 Elsevier Ltd. All rights reserved.

An Analysis of Unit Costs at a Consolidated Supply Depot

Science.gov (United States)

1990-12-01

Not-For-Profit Setting,"The Accounting Review,July 1990. Horngren , C. T., Cost Accountinq:A Managerial Emphasis,3rd ed, Prentice-Hall Inc.,1972...sector has used concepts of unit costs for 4 decades. Any managerial or cost accounting text discusses in some length unit costs . For Defense contractors...the Cost Accounting Standards Board (CASB) provides guidance for contract costs . Unit costs include direct, indirect, and general and administrative

Priming of antiherbivore defensive responses in plants

Institute of Scientific and Technical Information of China (English)

Jinwon Kim; Gary W.Felton

2013-01-01

Defense priming is defined as increased readiness of defense induction.A growing body of literature indicates that plants (or intact parts of a plant) are primed in anticipation of impending environmental stresses,both biotic and abiotic,and upon the following stimulus,induce defenses more quickly and strongly.For instance,some plants previously exposed to herbivore-inducible plant volatiles (HIPVs) from neighboring plants under herbivore attack show faster or stronger defense activation and enhanced insect resistance when challenged with secondary insect feeding.Research on priming of antiherbivore defense has been limited to the HIPV-mediated mechanism until recently,but significant advances were made in the past three years,including non-HIPV-mediated defense priming,epigenetic modifications as the molecular mechanism of priming,and others.It is timely to consider the advances in research on defense priming in the plantinsect interactions.

Policy implications of the Strategic Defense Initiative

International Nuclear Information System (INIS)

Goodwin, R.C.

1991-01-01

Specific topics include: the technological feasibility of proposed components and architectures; the compatibility of the proposed systems with existing and proposed arms control agreements, with special emphasis upon the ABM Treaty, Outer Space Treaty, the Defense and Space Treaty, and the START Treaty; the compatibility of proposed systems with classical warfare doctrine and the four modern strategic nuclear doctrines of Massive Retaliation, Assured Destruction, Countervailing and Flexible Response; the economics of strategic defense including an assessment of overall governmental spending, of the suballocation for defense, and of the feasibility of defensive systems which are cost-effective at the margin; and, in summary, an assessment of the New Strategic Concept which balances arms control, offensive forces, and defensive forces. This study falls within the realm of defense policy analysis in that it attempts to determine whether the administration's proposed Strategic Defense Initiative, as well as the long-term strategic defensive systems derived from SDI research, constitute efficient, desirable allocation of scarce government resources - especially in a period of seemingly relaxed superpower tensions and numerous demands upon those resources

Effect of Pitavastatin Treatment on ApoB-48 and Lp-PLA₂ in Patients with Metabolic Syndrome: Substudy of PROspective Comparative Clinical Study Evaluating the Efficacy and Safety of PITavastatin in Patients with Metabolic Syndrome.

Science.gov (United States)

Lee, Hyo Sun; Jung, Chang Hee; Kim, Sung Rae; Jang, Hak Chul; Park, Cheol Young

2016-03-01

Apolipoprotein (Apo) B-48 is an intestinally derived lipoprotein that is expected to be a marker for cardiovascular disease (CVD). Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is a vascular-specific inflammatory marker and important risk predictor of CVD. The aim of this study was to explore the effect of pitavastatin treatment and life style modification (LSM) on ApoB-48 and Lp-PLA₂ levels in metabolic syndrome (MS) patients at relatively low risk for CVD, as a sub-analysis of a previous multi-center prospective study. We enrolled 75 patients with MS from the PROPIT study and randomized them into two treatment groups: 2 mg pitavastatin daily+intensive LSM or intensive LSM only. We measured the change of lipid profiles, ApoB-48 and Lp-PLA₂ for 48 weeks. Total cholesterol, low density lipoprotein cholesterol, non-high density lipoprotein cholesterol, and ApoB-100/A1 ratio were significantly improved in the pitavastatin+LSM group compared to the LSM only group (P≤0.001). Pitavastatin+LSM did not change the level of ApoB-48 in subjects overall, but the level of ApoB-48 was significantly lower in the higher mean baseline value group of ApoB-48. The change in Lp-PLA₂ was not significant after intervention in either group after treatment with pitavastatin for 1 year. Pitavastatin treatment and LSM significantly improved lipid profiles, ApoB-100/A1 ratio, and reduced ApoB-48 levels in the higher mean baseline value group of ApoB-48, but did not significantly alter the Lp-PLA₂ levels.

The Integration Role of European Defense Procurement in Achieving a More Competitive and Stronger European Defense Equipment Market

Science.gov (United States)

2015-06-01

and systems, even monopolistic ) essence of the supply side of the defense market . There are only a few suppliers that can meet today’s complex...DEFENSE PROCUREMENT IN ACHIEVING A MORE COMPETITIVE AND STRONGER EUROPEAN DEFENSE EQUIPMENT MARKET by Kiril O. Angelov June 2015 Thesis Advisor...COMPETITIVE AND STRONGER EUROPEAN DEFENSE EQUIPMENT MARKET 5. FUNDING NUMBERS 6. AUTHOR(S) Kiril O. Angelov 7. PERFORMING ORGANIZATION NAME(S) AND