WorldWideScience

Sample records for unit telescopes ut

  1. VLT Unit Telescopes Named at Paranal Inauguration

    Science.gov (United States)

    1999-03-01

    This has been a busy, but also a very successful and rewarding week for the European Southern Observatory and its staff. While "First Light" was achieved at the second 8.2-m VLT Unit Telescope (UT2) ahead of schedule, UT1 produced its sharpest image so far. This happened at a moment of exceptional observing conditions in the night between March 4 and 5, 1999. During a 6-min exposure of the majestic spiral galaxy, NGC 2997 , stellar images of only 0.25 arcsec FWHM (full-width half-maximum) were recorded. This and two other frames of nearly the same quality have provided the base for the beautiful colour-composite shown above. At this excellent angular resolution, individual star forming regions are well visible along the spiral arms. Of particular interest is the peculiar, twisted shape of the long spiral arm to the right. The Paranal Inauguration The official inauguration of the Paranal Observatory took place in the afternoon of March 5, 1999, in the presence of His Excellency, the President of the Republic of Chile, Don Eduardo Frei Ruiz-Tagle, and ministers of his cabinet, as well the Ambassadors to Chile of the ESO member states and many other distinguished guests. The President of the ESO Council, Mr. Henrik Grage, and the ESO Director General, Professor Riccardo Giacconi, were the foremost representatives of the ESO organisation; most members of the ESO Council and ESO staff also participated. A substantial number of media representatives from Europe and Chile were present and reported - often live - from Paranal during the afternoon and evening. The guests were shown the impressive installations at the new observatory, including the first and second 8.2-m VLT Unit Telescopes; the latter having achieved "First Light" just four days before. A festive ceremony took place in the dome of UT2, under the large telescope structure that had been tilted towards the horizon to make place for the numerous participants. After an introductory address by the ESO Director

  2. Two VLT 8.2-m Unit Telescopes in Action

    Science.gov (United States)

    1999-04-01

    Visitors at ANTU - Astronomical Images from KUEYEN The VLT Control Room at the Paranal Observatory is becoming a busy place indeed. From here, two specialist teams of ESO astronomers and engineers now operate two VLT 8.2-m Unit Telescopes in parallel, ANTU and KUEYEN (formerly UT1 and UT2, for more information about the naming and the pronunciation, see ESO Press Release 06/99 ). Regular science observations have just started with the first of these giant telescopes, while impressive astronomical images are being obtained with the second. The work is hard, but the mood in the control room is good. Insiders claim that there have even been occasions on which the groups have had a friendly "competition" about which telescope makes the "best" images! The ANTU-team has worked with the FORS multi-mode instrument , their colleagues at KUEYEN use the VLT Test Camera for the ongoing tests of this new telescope. While the first is a highly developed astronomical instrument with a large-field CCD imager (6.8 x 6.8 arcmin 2 in the normal mode; 3.4 x 3.4 arcmin 2 in the high-resolution mode), the other is a less complex CCD camera with a smaller field (1.5 x 1.5 arcmin 2 ), suited to verify the optical performance of the telescope. As these images demonstrate, the performance of the second VLT Unit Telescope is steadily improving and it may not be too long before its optical quality will approach that of the first. First KUEYEN photos of stars and galaxies We present here some of the first astronomical images, taken with the second telescope, KUEYEN, in late March and early April 1999. They reflect the current status of the optical, electronic and mechanical systems, still in the process of being tuned. As expected, the experience gained from ANTU last year has turned out to be invaluable and has allowed good progress during this extremely delicate process. ESO PR Photo 19a/99 ESO PR Photo 19a/99 [Preview - JPEG: 400 x 433 pix - 160k] [Normal - JPEG: 800 x 866 pix - 457k] [High

  3. VLTI-UT vibrations effort and performances

    Science.gov (United States)

    Poupar, Sébastien; Haguenauer, Pierre; Alonso, Jaime; Schuhler, Nicolas; Henriquez, Juan-Pablo; Berger, Jean-Philippe; Bourget, Pierre; Brillant, Stephane; Castillo, Roberto; Gitton, Philippe; Gonte, Frederic; Di Lieto, Nicola; Lizon, Jean-Louis; Merand, Antoine; Woillez, Julien

    2014-07-01

    The ESO Very Large Telescope Interferometer (VLTI) using the Unit Telescope (UT) was strongly affected by vibrations since the first observations. Investigation by ESO on that subject had started in 2007, with a considerable effort since mid 2008. An important number of investigations on various sub-systems (On telescope: Guiding, Passive supports, Train Coude, insulation of electronics cabinets; On Instruments: dedicated campaign on each instruments with a special attention on the ones equipped with Close Cycle Cooler) were realized. Vibrations were not only recorded and analyzed using the usual accelerometers but also using on use sub-systems as InfRared Image Sensor (IRIS) and Multiple Applications Curvature Adaptive Optics (MACAO) and using a specific tool developed for vibrations measurements Mirror vibrAtion Metrology systeM for the Unit Telescope (MAMMUT). Those tools and systems have been used in order to improve the knowledge on telescope by finding sources. The sources whenever it was possible were damped. As known for years, instruments are still the principal sources of vibrations, for the majority of the UT. A special test in which 2 UTs instruments were completely shut down was realized to determine the minimum Optical Path Length (OPL) achievable. Vibrations is now a part of the instruments interface document and during the installation of any new instrument (KMOS) or system (AOF) a test campaign is realized. As a result some modifications (damping of CCC) can be asked in case of non-compliance. To ensure good operational conditions, levels of vibrations are regularly recorded to control any environmental change.

  4. Design, fabrication, integration and commissioning of an upgraded guiding probe for the VLT unit telescope 4

    Science.gov (United States)

    Frank, Christoph; Hammersley, Peter; Buzzoni, Bernard; Manescau, Antonio; Arsenault, Robin; Madec, Pierre-Yves; Birkmann, Martin; Mueller, Michael; Salgado, Fernando; Guisard, Stephane; Kroedel, Matthias

    2014-07-01

    As part of the preparation for the arrival of the MUSE instrument to the VLT, it was required to adapt the hosting telescope (UT4) guide probe, to increase its back focal length. This is to allow enough space for the later deployment of the MUSE Adaptive Optics module GALACSI, in-between the telescope adapter rotator and the instrument itself. The UT guide probe is a critical component for the successful operation of the telescope, so its modification to increase the telescope's back focal length, while maintaining full compatibility with the existing operation model and other hardware, was rather demanding. The design, manufacture, assembly and test for the new supporting arm in the UT guiding probe is presented. It mixes the use of novel materials (HB-CESIC® for the mirrors substrates) and state of the art manufacturing techniques (3D printing mould production and rapid casting for the support structure), which allow producing easily a high performance subsystem. Characterization of the system prior delivery to the telescope, its integration in the UT and results after commissioning is presented. Its successful implementation has validated new manufacturing techniques that may prove very useful for future instruments development.

  5. The optical detection unit for Baikal-GVD neutrino telescope

    Directory of Open Access Journals (Sweden)

    Avrorin A.D.

    2016-01-01

    Full Text Available The first stage of the GVD-cluster composed of five strings was deployed in April 2014. Each string consists of two sections with 12 optical modules per section. A section is the basic detection unit of the Baikal neutrino telescope. We will describe the section design, review its basic elements – optical modules, FADC readout units, slow control and calibration systems, and present selected results for section in-situ tests in Lake Baikal.

  6. Echelle spectra of SN2014J from the Apache Point Observatory 3.5m telescope, UT January 27 and January 30, 2014

    Science.gov (United States)

    Ritchey, Adam M.; Welty, Daniel E.; Dahlstrom, Julie A.; York, Donald G.

    2014-02-01

    Optical spectra of SN2014J were recorded with the ARC echelle spectrograph at Apache Point Observatory, at approximately UT Jan. 27.2 (7 spectra, 8400 s) and UT Jan. 30.4, (6 spectra, 7200s), through thin clouds in seeing averaging 1.0 arcsec. The resolving power is 31,500. Useful interstellar spectra were obtained from 3850A to 9000A; estimated S/N values (photon counts only) near 6563A are 500 on Jan 27 and 400 on Jan 30, and about 1/3 those values at Ca II 3933A.

  7. A 200-GHz telescope unit for the QUIJOTE CMB Experiment

    Science.gov (United States)

    Sanquirce, Rubén.; Etxeita, Borja; Murga, Gaizka; Fernandez, Esther; Sainz, Iñaki; Sánchez, Vicente; Viera-Curbelo, Teodora A.; Gómez, María. F.; Aguiar-Gonzalez, Marta; Hoyland, Roger J.; Pérez de Taoro, Ángeles R.; Vega, Afrodisio; Rebolo-López, Rafael; Rubiño, Jose Alberto

    2014-07-01

    Experiment QUIJOTE (Q-U-I JOint TEnerife) is a scientific collaboration, leaded by the Instituto de Astrofísica de Canarias (IAC), which can measure the polarization of the Cosmic Microwave Background (CMB) in the range of frequency up to 200 GHz, at angular scales of 1°. The project is composed of 2 telescopes and 3 instruments, located in Teide Observatory (Tenerife, Spain). After the successful delivery of the first telescope (operative since 2012), Idom is currently involved on the turn key supply of the second telescope (phase II). The work started in June 2013 and it will be completed in a challenging period of 12 months (operative at the beginning of July 2014), including design, factory assembly and testing, transport and final commissioning on site. This second unit will improve the opto-mechanical performance and maintainability. The telescope will have an unlimited rotation capacity in azimuth axis and a range of movement between 25°-95° in elevation axis. An integrated rotary joint will transmit fluid, power and signal to the rotary elements. The pointing and tracking accuracy will be significantly below to specification: 1.76 arcmin and 44 arcsec, respectively. This project completes Idoḿs contribution during phase I, which also comprises the integration and functional tests for the 5 polarimeters of the first instrument in Bilbao headquarters, and the design and supervision of the building which protects both telescopes, including the installation and commissioning of the mechanism for shutters aperture.

  8. A new Cassegrain calibration lamp unit for the Blanco Telescope

    Science.gov (United States)

    Points, S. D.; James, D. J.; Tighe, R.; Montané, A.; David, N.; Martínez, M.

    2016-08-01

    The f/8 RC-Cassegrain Focus of the Blanco Telescope at Cerro Tololo Inter-American Observatory, hosts two new instruments: COSMOS, a multi-object spectrograph in the visible wavelength range (350 - 1030nm), and ARCoIRIS, a NIR cross-dispersed spectrograph featuring 6 spectral orders spanning 0.8 - 2.45μm. Here we describe a calibration lamp unit designed to deliver the required illumination at the telescope focal plane for both instruments. These requirements are: (1) an f/8 beam of light covering a spot of 92mm diameter (or 10 arcmin) for a wavelength range of 0.35μm through 2.5μm and (2) no saturation of flat-field calibrations for the minimal exposure times permitted by each instrument, and (3) few saturated spectral lines when using the wavelength calibration lamps for the instruments. To meet these requirements this unit contains an adjustable quartz halogen lamp for flat-field calibrations, and one hollow cathode lamp and four penray lamps for wavelength calibrations. The wavelength calibration lamps are selected to provide optimal spectral coverage for the instrument mounted and can be used individually or in sets. The device designed is based on an 8-inch diameter integrating sphere, the output of which is optimized to match the f/8 calibration input delivery system which is a refractive system based on fused-silica lenses. We describe the optical design, the opto-mechanical design, the electronic control and give results of the performance of the system.

  9. Ten years maintaining MACAO-VLTI units in operation in the Very Large Telescope at Paranal Observatory

    Science.gov (United States)

    Salgado, F.; Hudepohl, G.

    2016-07-01

    More than 10 years have already passed since the first Multiple Application Curvature Adaptive Optics (MACAO) facilities got the first light in UT2 the 18th of April, 2003, in the Very Large Telescope (VLT) at Paranal Observatory. The achievable image sharpness of a ground-based telescope is normally limited by the effect of atmospheric turbulence. However, with Adaptive Optics (AO) techniques, this major drawback can be overcome so that the telescope produces images that are as sharp as theoretically possible, i.e., as if they were taken from space. [1] The intention of this document is summarize in few pages some highlights related with the activities needed to keep MACAO units in operation. Some statistics of problems based in Action Remedy tool is included, showing how through these years the number of problems has been reduced, even when there are still some unsolved ones. Some lessons have been learned and there are others one to learn. Corrective and predictive maintenance performed are shown too like the current measurements, transfer functions measurements, thermography pictures, health checks measuring interaction matrix and flat vectors to detect dead APDs or short circuits in the DM, etc. Some forced interventions are included as well like the removal of the cabinets from Coude rooms to avoid that acoustic noise and vibrations perturb the operations, the deformable mirrors reached by cooling leaks and a mirror that got rusty are shown too. Well knowledge of the system, good interaction between different disciplines groups to perform corrective and preventive maintenance seems to be key aspects of keeping it under control and operative during all these years leading to this good result.

  10. VLT 8.2-m Unit Telescope no. 1 (as on September 7, 1995)

    Science.gov (United States)

    1995-09-01

    ESO Press Photos 28-30/95; 13 September 1995 The construction of the ESO Very Large Telescope (VLT) advances rapidly, both in Europe and in Chile. These three photos show some of the main mechanical parts of the first 8.2-metre telescope, as they presented themselves in Milan (Italy) on Thursday, September 7, 1995. Two versions of these photos, one smaller and one larger and with better image resolution, are accessible for convenient transfer over the networks. The mechanical structure of VLT Unit Telescope no. 1 is now in the process of being mounted at the Ansaldo Energia premises in Milan (Italy). The so-called main structure (i.e., telescope azimuth and altitude mechanical structure, including hydrostatic bearing system, direct drives and direct mounted encoding system) was designed and is being built by the Italian consortium AES, composed of Ansaldo Energia (Genova), SOIMI (Milan) and EIE (Venice). Already two months from now, in November 1995, the complete, enormous mechanical structures of this telescope will be moving on the azimuth hydrostatic bearing tracks, using the direct drive system designed and built by the PHASE Company (Genova, Italy). The thorough testing phase will start by the end of December 1995 or at the beginning of January 1996. ESO Press Photo 28/95 [54K] [248K] shows the lower part of the azimuth structure of the telescope (the fork) on the concrete pier on which the azimuth tracks (hydrostatic bearing journal) are mounted. The very high accuracy of this enormous structure (compare with the persons in the photo!) is illustrated by the fact that the "run-out" of the azimuth axis of the fork has been measured as only 80 microns (0.08 millimetres) on 90 degrees turning angle. This is a remarkable result, especially since the centering of the axis is done on a radial journal with a diameter of no less than 9 metres. When the fork is equipped with all auxiliary systems, it will weigh about 320 t, will be 18 metres long and 8 metres wide. It

  11. United Kingdom Infrared Telescope's Spectrograph Observations of Human-Made Space Objects

    Science.gov (United States)

    Buckalew, Brent; Abercromby, Kira; Lederer, Susan; Frith, James; Cowardin, Heather

    2017-01-01

    Presented here are the results of the United Kingdom Infrared Telescope (UKIRT) spectral observations of human-made space objects taken from 2014 to 2015. The data collected using the UIST infrared spectrograph cover the wavelength range 0.7-2.5 micrometers. Overall, data were collected on 18 different orbiting objects at or near the geosynchronous (GEO) regime. Thirteen of the objects are spacecraft, one is a rocket body, and four are cataloged as debris pieces. The remotely collected data are compared to the laboratory-collected reflectance data on typical spacecraft materials; thereby general materials are identified but not specific types. These results highlight the usefulness of observations in the infrared by focusing on features from hydrocarbons and silicon. The spacecraft show distinct features due to the presence of solar panels. Signature variations between rocket bodies, due to the presence of various metals and paints on their surfaces, show a clear distinction from those objects with solar panels, demonstrating that one can distinguish most spacecraft from rocket bodies through infrared spectrum analysis. Finally, the debris pieces tend to show featureless, dark spectra. These results show that the laboratory data in its current state give excellent indications as to the nature of the surface materials on the objects. Further telescopic data collection and model updates to include more materials, noise, surface roughness, and material degradation are necessary to make better assessments of orbital object material types. A comparison conducted between objects observed previously with the NASA Infrared Telescope Facility (IRTF) shows similar materials and trends from the two telescopes and from the two distinct data sets. However, based on the current state of the model, infrared spectroscopic data are adequate to classify objects in GEO as spacecraft, rocket bodies, or debris.

  12. United Kingdom Infrared Telescope's Spectrograph Observations of Human-Made Space Objects

    Science.gov (United States)

    Buckalew, Brent; Abercromby, Kira; Lederer, Susan; Cowardin, Heather; Frith, James

    2017-01-01

    Presented here are the results of the United Kingdom Infrared Telescope (UKIRT) spectral observations of human-made space objects taken from 2014 to 2015. The data collected using the UKIRT 1-5 micron Imager Spectrometer (UIST) cover the wavelength range 0.7-2.5 micrometers. Overall, data were collected on 18 different orbiting objects at or near geosynchronous orbit (GEO). Two of the objects are controlled spacecraft, twelve are non-controlled spacecraft, one is a rocket body, and three are cataloged as debris. The remotely collected data are compared to the laboratory-collected reflectance data on typical spacecraft materials; thereby general materials are identified but not specific types. These results highlight the usefulness of observations in the infrared by focusing on features from hydrocarbons and silicon. The spacecraft, both the controlled and non-controlled, show distinct features due to the presence of solar panels whereas the rocket bodies do not. Signature variations between rocket bodies, due to the presence of various metals and paints on their surfaces, show a clear distinction from those objects with solar panels, demonstrating that one can distinguish most spacecraft from rocket bodies through infrared spectrum analysis. Finally, the debris pieces tend to show featureless, dark spectra. These results show that the laboratory data in its current state give well-correlated indications as to the nature of the surface materials on the objects. Further telescopic data collection and model updates to include noise, surface roughness, and material degradation are necessary to make better assessments of orbital object material types. A comparison conducted between objects observed previously with the NASA Infrared Telescope Facility (IRTF) shows similar materials and trends from the two telescopes and different times. However, based on the current state of the model, infrared spectroscopic data are adequate to classify objects in GEO as spacecraft

  13. Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.

    Science.gov (United States)

    Ilori, Titilayo O; Wang, Yanhua; Blount, Mitsi A; Martin, Christopher F; Sands, Jeff M; Klein, Janet D

    2012-04-15

    UT-A1, the urea transporter present in the apical membrane of the inner medullary collecting duct, is crucial to the kidney's ability to concentrate urine. Phosphorylation of UT-A1 on serines 486 and 499 is important for plasma membrane trafficking. The effect of calcineurin on dephosphorylation of UT-A1 was investigated. Inner medullary collecting ducts from Sprague-Dawley rats were metabolically labeled and treated with tacrolimus to inhibit calcineurin or calyculin to inhibit protein phosphatases 1 and 2A. UT-A1 was immunoprecipitated, electrophoresed, blotted, and total UT-A1 phosphorylation was assessed by autoradiography. Total UT-A1 was determined by Western blotting. A phospho-specific antibody to pser486-UT-A1 was used to determine whether serine 486 can be hyperphosphorylated by inhibiting phosphatases. Inhibition of calcineurin showed an increase in phosphorylation per unit protein at serine 486. In contrast, inhibition of phosphatases 1 and 2A resulted in an increase in UT-A1 phosphorylation but no increase in pser486-UT-A1. In vitro perfusion of inner medullary collecting ducts showed tacrolimus-stimulated urea permeability consistent with stimulated urea transport. The location of phosphorylated UT-A1 in rats treated acutely and chronically with tacrolimus was determined using immunohistochemistry. Inner medullary collecting ducts of the acutely treated rats showed increased apical membrane association of phosphorylated UT-A1 while chronic treatment reduced membrane association of phosphorylated UT-A1. We conclude that UT-A1 may be dephosphorylated by multiple phosphatases and that the PKA-phosphorylated serine 486 is dephosphorylated by calcineurin. This is the first documentation of the role of phosphatases and the specific site of phosphorylation of UT-A1, in response to tacrolimus.

  14. Telecom Innovator UT Starcom eyes new opportunities with IPTV

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Wu Ying, the 47-year-old Chairman and CEO of UT Starcom China, started his company Starcom with another Chinese student studying in the United States in 1991, in New Jersey. The company merged with California-based Unitech, also founded by overseas Chinese students, in 1995 to form UT Starcom. As a successful returnee to China, Wu shared his views on innovation in an interview with Beijing Review on March 22: The Chinese Government is encouraging innovation. Even the top leaders are advocating innovation...

  15. Assembly and test results of the AOF laser guide star units at ESO

    Science.gov (United States)

    Hackenberg, W.; Bonaccini Calia, D.; Buzzoni, B.; Comin, M.; Dupuy, C.; Gago, F.; Guidolin, I. M.; Guzman, R.; Holzloehner, R.; Kern, L.; Kirchbauer, J.-.; Lewis, S.; Lizon, J.-.; McLay, S.; Pfrommer, T.; Quattri, M.; Quentin, J.; Ridings, R.

    2014-08-01

    The Four Laser Guide Star Facility (4LGSF) is part of the ESO Adaptive Optics Facility, in which one of the VLT telescopes, UT4, is transformed in an adaptive telescope-equipped with a deformable secondary mirror, two adaptive optics systems at the Nasmyth focii and four sodium laser guide star modular units. In this paper we present the design, the assembly and validation test performed so far in Europe on the first laser guide star unit.

  16. KOALA, a wide-field 1000 element integral-field unit for the Anglo-Australian Telescope: assembly and commissioning

    Science.gov (United States)

    Zhelem, Ross; Brzeski, Jurek; Case, Scott; Churilov, Vladimir; Ellis, Simon; Farrell, Tony; Green, Andrew; Heng, Anthony; Horton, Anthony; Ireland, Michael; Jones, Damien; Klauser, Urs; Lawrence, Jon; Miziarski, Stan; Orr, David; Pai, Naveen; Staszak, Nick; Tims, Julia; Vuong, Minh; Waller, Lew; Xavier, Pascal

    2014-07-01

    The KOALA optical fibre feed for the AAOmega spectrograph has been commissioned at the Anglo-Australian Telescope. The instrument samples the reimaged telescope focal plane at two scales: 1.23 arcsec and 0.70 arcsec per image slicing hexagonal lenslet over a 49x27 and 28x15 arcsec field of view respectively. The integral field unit consists of 2D hexagonal and circular lenslet arrays coupling light into 1000 fibres with 100 micron core diameter. The fibre run is over 35m long connecting the telescope Cassegrain focus with the bench mounted spectrograph room where all fibres are reformatted into a one-dimensional slit. Design and assembly of the KOALA components, engineering challenges encountered, and commissioning results are discussed.

  17. Observations of Lick Standard Stars Using the SCORPIO Multi-Slit Unit at the SAO 6-m Telescope

    CERN Document Server

    Sharina, M E; Puzia, T

    2006-01-01

    We present Lick line-index measurements of standard stars from the list of Worthey. The spectra were taken with the multi-slit unit of the SCORPIO spectrograph at the 6-m Special Astrophysical observatory telescope. We describe in detail our method of analysis and explain the importance of using the Lick index system for studying extragalactic globular clusters. Our results show that the calibration of our instrumental system to the standard Lick system can be performed with high confidence.

  18. Final acceptance of the 200 GHz telescope unit for the QUIJOTE CMB experiment

    Science.gov (United States)

    Sanquirce-García, R.; Sainz-Pardo, I.; Etxeita-Arriaga, B.; Murga-Llano, Gaizka; Fernandez-Santos, E.; Sánchez-de-la-Rosa, V.; Viera-Curbelo, T. A.; Gómez-Reñasco, F.; Aguiar-González, M.; Pérez de Taoro, M. R.; Rubiño-Martín, J. A.

    2016-07-01

    The QUIJOTE (Q-U-I JOint TEnerife) experiment is a scientific collaboration, led by the Instituto de Astrofísica de Canarias (IAC), with the aim of measuring the polarization of the Cosmic Microwave Background (CMB) in the frequency range 10-40 GHz and at large angular scales (around 1°). The project is composed of 2 telescopes and 3 instruments, located in Teide Observatory (Tenerife, Spain). Idoḿs contribution for this project is divided in two phases. Phase I consisted on the design, assembly and factory testing of the first telescope (2008), the integration and functional tests for the 5 polarimeters of the first instrument (2009), and the design and construction supervision of the building which protects both telescopes (2009), including the installation and commissioning of the mechanism for domes apertures. Phase II comprised the design, factory assembly and testing, transport and final commissioning on site of the second telescope, which finished in January 2015. The optical design of both telescopes should allow them to reach up to 200 GHz. The required opto-mechanical performance was checked under nominal conditions, reaching a pointing and tracking accuracy lower than 5 arcsec in both axes, 8 times better than specified. Particular inspections and tests were carried out for critical systems, as the rotary joint that transmits fluid, power and signal to the rotary elements, or for the safety system to ensure personnel and hardware protection under emergency conditions. This paper contains a comprehensive description of the power electronics and acquisition/control design required for safely operation under nominal and emergency conditions, as well as a detailed description of the factory and observatory tests required for the final acceptance of the telescope

  19. Art ist kuku nu ut / Indrek Grigor

    Index Scriptorium Estoniae

    Grigor, Indrek

    2009-01-01

    Tartu kunstikuust "Art ist kuku nu ut", mis toimus 9. jaanuarist 29. veebruarini. Peakorraldaja Kaisa Eiche. Programmist, välireklaamist, kunstinäitustest, Bernard Murigneux' valgusskulptuuridest, Lemmit Kaplinski kunstikriitika töötubade sarjast "Kriitikavabrik"

  20. First Images and Spectra from ISAAC on UT1

    Science.gov (United States)

    1998-11-01

    New VLT Instrument Delivers Spectacular Infrared Views of the Southern Sky The VLT Infrared Spectrometer And Array Camera (ISAAC) [1] was installed at the first 8.2-m VLT Unit Telescope (UT1) on November 14, 1998, cf. ESO PR Photos 42a-h/98. ISAAC is the second major VLT instrument to be installed at the VLT and the first to be fully designed and developed at ESO within its Instrumentation Division. Following evacuation of its large vacuum vessel, cooling to cryogenic temperature and alignment with the telescope according to the planned schedule, it successfully achieved technical first light during the night between November 16 and 17, 1998. ESO PR Photo 46a/98 ESO PR Photo 46a/98 [JPEG: 800 x 847 pix - 432k] [High-Res - JPEG: 3000 x 3175 pix - 2.9Mb] PR Photo 46a/98 shows ISAAC as it is now mounted at the UT1 Nasmyth B adaptor-rotator (right; blue colour). The co-rotator system (left) through which the various cables are fed to the instrument, is also well visible. (Photo obtained on November 16, 1998). The first focus tests on stars yielded images of excellent sharpness, around 0.45 arcsec full-width-half-maximum (FWHM). During the following nights, even better images, as small as 0.25 arcsec in relatively short exposures, were obtained, testifying to the quality of the site as well as the optical quality of both the telescope and instrument. Observations were executed using the new VLT Control and Data Flow Systems which are driven by Observation Blocks that define all details of the required astronomical exposures. In addition to direct images in various infrared colours (selected with different optical filters), spectroscopic observations were also made during the first few nights of operation. This Press Release is accompanied by several images and spectra which illustrate some of the exceptional new astronomical capabilities offered by this instrument. Star-Forming Region RCW38 in the Milky Way ESO PR Photo 46b/98 ESO PR Photo 46b/98 [Preview - JPEG: 800 x

  1. Measurement of the UT angle phi_2

    CERN Document Server

    Mohanty, Gagan B

    2011-01-01

    We give a status report on measurements of the angle phi_2 (alpha) of the CKM unitarity triangle (UT) and the so-called Kpi puzzle. Results presented are mostly from the two B-factory experiments, Belle and BaBar.

  2. Hur ser egentligen AKK-samspel ut?

    DEFF Research Database (Denmark)

    Pilesjö, Maja Sigurd

    Hur ser egentligen AKK-samspel ut? Interaktionsmönster mellan barn med omfattande kommunikativ och motorisk funktionsnedsättning och deras vardagliga samtalspartners. Hur kan egentligen samspel mellan barn med kommunikationsvårighe- ter gå till och faktiskt också fung- era? Maja Sigurd Pilesjö...

  3. 76 FR 15357 - Utah Disaster #UT-00009

    Science.gov (United States)

    2011-03-21

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Utah Disaster UT-00009 AGENCY: U.S. Small Business Administration. ACTION: Amendment 1. SUMMARY: This is an amendment of the Presidential declaration of a major disaster for Public Assistance Only...

  4. 76 FR 10081 - Utah Disaster #UT-00009

    Science.gov (United States)

    2011-02-23

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Utah Disaster UT-00009 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  5. 77 FR 7229 - Utah Disaster #UT-00011

    Science.gov (United States)

    2012-02-10

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Utah Disaster UT-00011 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  6. 76 FR 50807 - Utah Disaster #UT-00010

    Science.gov (United States)

    2011-08-16

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Utah Disaster UT-00010 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  7. 77 FR 61652 - Utah Disaster # UT-00015

    Science.gov (United States)

    2012-10-10

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Utah Disaster UT-00015 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the State of UTAH dated...

  8. 77 FR 67858 - Utah Disaster #UT-00021

    Science.gov (United States)

    2012-11-14

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Utah Disaster UT-00021 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for...

  9. Athermal laser launch telescopes

    NARCIS (Netherlands)

    Kamphues, F.G.; Henselmans, R.; Rijnveld, N.; Lemmen, M.H.J.; Doelman, N.J.; Nijkerk, M.D.

    2011-01-01

    ESO has developed a concept for a compact laser guide star unit for use in future Adaptive Optics (AO) systems. A small powerful laser is combined with a telescope that launches the beam, creating a single modular unit that can be mounted directly on a large telescope. This approach solves several

  10. Athermal laser launch telescopes

    NARCIS (Netherlands)

    Kamphues, F.G.; Henselmans, R.; Rijnveld, N.; Lemmen, M.H.J.; Doelman, N.J.; Nijkerk, M.D.

    2011-01-01

    ESO has developed a concept for a compact laser guide star unit for use in future Adaptive Optics (AO) systems. A small powerful laser is combined with a telescope that launches the beam, creating a single modular unit that can be mounted directly on a large telescope. This approach solves several o

  11. The VLT Adaptive Optics Facility Project: Telescope Systems

    Science.gov (United States)

    Arsenault, Robin; Hubin, Norbert; Stroebele, Stefan; Fedrigo, Enrico; Oberti, Sylvain; Kissler-Patig, Markus; Bacon, Roland; McDermid, Richard; Bonaccini-Calia, Domenico; Biasi, Roberto; Gallieni, Daniele; Riccardi, Armando; Donaldson, Rob; Lelouarn, Miska; Hackenberg, Wolfgang; Conzelman, Ralf; Delabre, Bernard; Stuik, Remko; Paufique, Jerome; Kasper, Markus; Vernet, Elise; Downing, Mark; Esposito, Simone; Duchateau, Michel; Franx, Marijn; Myers, Richard; Goodsell, Steven

    2006-03-01

    The Adaptive Optics Facility is a project to convert UT4 into a specialised Adaptive Telescope. The present secondary mirror (M2) will be replaced by a new M2-Unit hosting a 1170-actuator deformable mirror. The three focal stations will be equipped with instruments adapted to the new capability of this UT. Two instruments have been identified for the two Nasmyth foci: Hawk-I with its AO module GRAAL allowing a Ground Layer Adaptive Optics correction and MUSE with GALACSI for GLAO correction and Laser Tomography Adaptive Optics correction. A future instrument still needs to be defined for the Cassegrain focus. Several guide stars are required for the type of adaptive corrections needed and a Four Laser Guide Star Facility (4LGSF) is being developed in the scope of the AO Facility. Convex mirrors like the VLT M2 represent a major challenge for testing and a substantial effort is dedicated to this. ASSIST, is a test bench that will allow testing of the Deformable Secondary Mirror and both instruments with simulated turbulence. This article focusses on the telescope systems (Adaptive Secondary, Four Laser Guide Star Facility, RTC platform and ASSIST Test Bench). The following article describes the AO Modules GALACSI and GRAAL.

  12. Unified Medical Language System Terminology Services (UTS) API

    Data.gov (United States)

    U.S. Department of Health & Human Services — The UTS API is intended for application developers to perform Web service calls and retrieve UMLS data within their own applications. The UTS API provides the...

  13. 75 FR 62627 - Environmental Impact Statement; Davis County, UT

    Science.gov (United States)

    2010-10-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement; Davis County, UT AGENCY: Federal Highway... Department of Transportation, Region One Office, 166 West Southwell Street, Ogden, UT 84404-4194,...

  14. 75 FR 9476 - Environmental Impact Statement: Salt Lake County, UT

    Science.gov (United States)

    2010-03-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement: Salt Lake County, UT AGENCY: Federal... Engineer, Federal Highway Administration, 2520 West 4700 South, Suite 9A, Salt Lake City, UT...

  15. The MaNGA Integral Field Unit Fiber Feed System for the Sloan 2.5 m Telescope

    CERN Document Server

    Drory, N; Bershady, M A; Bundy, K; Gunn, J; Law, D R; Smith, M; Stoll, R; Tremonti, C A; Wake, D A; Yan, R; Weijmans, A M; Byler, N; Cherinka, B; Cope, F; Eigenbrot, A; Harding, P; Holder, D; Huehnerhoff, J; Jaehnig, K; Jansen, T C; Klaene, M; Paat, A M; Percival, J; Sayres, C

    2014-01-01

    We describe the design, manufacture, and performance of bare-fiber integral field units (IFUs) for the SDSS-IV survey MaNGA (Mapping Nearby Galaxies at APO) on the the Sloan 2.5 m telescope at Apache Point Observatory (APO). MaNGA is a luminosity-selected integral-field spectroscopic survey of 10,000 local galaxies covering 360-1030 nm at R ~ 2200. The IFUs have hexagonal dense packing of fibers with packing regularity of 3 um (RMS), and throughput of 96+/-0.5% from 350 nm to 1 um in the lab. Their sizes range from 19 to 127 fibers (3-7 hexagonal layers) using Polymicro FBP 120:132:150 um core:clad:buffer fibers to reach a fill fraction of 56%. High throughput (and low focal-ratio degradation) is achieved by maintaining the fiber cladding and buffer intact, ensuring excellent surface polish, and applying a multi-layer AR coating of the input and output surfaces. In operations on-sky, the IFUs show only an additional 2.3% FRD-related variability in throughput despite repeated mechanical stressing during plate ...

  16. SparsePak: A Formatted Fiber Field Unit for The WIYN Telescope Bench Spectrograph. I. Design, Construction, and Calibration

    CERN Document Server

    Bershady, M A; Harker, J; Ramsey, L W; Verheijen, M A W

    2004-01-01

    We describe the design and construction of a formatted fiber field-unit, SparsePak, and characterize its optical and astrometric performance. This array is optimized for spectroscopy of low-surface brightness, extended sources in the visible and near-infrared. SparsePak contains 82, 4.7" fibers subtending an area of 72"x71" in the telescope focal plane, and feeds the WIYN Bench spectrograph. Together, these instruments are capable of achieving spectral resolutions of lambda/dlambda ~ 20000 and an area--solid-angle product of ~140 arcsec^2 m^2 per fiber. Laboratory measurements of SparsePak lead to several important conclusions on the design of fiber termination and cable curvature to minimize focal ratio degradation. SparsePak itself has throughput >80% redwards of 5200 A, and 90-92% in the red. Fed at f/6.3, the cable delivers an output 90% encircled energy at nearly f/5.2. This has implications for performance gains if the WIYN Bench Spectrograph had a faster collimator. Our approach to integral-field spect...

  17. Ut pictura poesis: simbiosis dibujo y haiku

    OpenAIRE

    RAUSELL LLISO, ALMA

    2015-01-01

    Invetigación sobre la simbiosis entre dibujo y haikus. La intención no es ilustrar el haiku sino crear una retroalimentación entre ambas disciplinas fomentando la idea de un espectador activo que se involucre en el trabajo. Rausell Lliso, A. (2014). Ut pictura poesis: simbiosis dibujo y haiku. http://hdl.handle.net/10251/47638. Archivo delegado

  18. 75 FR 57374 - Establishment of Class E Airspace; Fillmore, UT

    Science.gov (United States)

    2010-09-21

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Fillmore, UT AGENCY... E airspace at Fillmore, UT, to accommodate aircraft using a new Area Navigation (RNAV) Global... Federal Register a notice of proposed rulemaking to establish controlled airspace at Fillmore, UT (75...

  19. 76 FR 1999 - Establishment of Class E Airspace; Panguitch, UT

    Science.gov (United States)

    2011-01-12

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Panguitch, UT AGENCY... E airspace at Panguitch, UT, to accommodate aircraft using a new Area Navigation (RNAV) Global... Panguitch, UT (75 FR 36585). The FAA agreed with a comment received to also expand controlled airspace...

  20. 75 FR 39148 - Establishment of Class E Airspace; Lucin, UT

    Science.gov (United States)

    2010-07-08

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Lucin, UT AGENCY..., UT, to facilitate vectoring of Instrument Flight Rules (IFR) traffic from en route airspace to Salt Lake City, UT. This will improve the safety and management of IFR operations for the Salt Lake City,...

  1. 78 FR 58158 - Establishment of Class E Airspace; Wasatch, UT

    Science.gov (United States)

    2013-09-23

    ... Establishment of Class E Airspace; Wasatch, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final... Tactical Air Navigational Aid (VORTAC) navigation aid, Wasatch, UT, to facilitate vectoring of Instrument... Federal Register a notice of proposed rulemaking (NPRM) to amend controlled airspace at Wasatch, UT (78...

  2. 76 FR 2800 - Establishment of Class E Airspace; Lucin, UT

    Science.gov (United States)

    2011-01-18

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Lucin, UT AGENCY... establishes Class E en route domestic airspace for the Lucin VORTAC, Lucin, UT. DATES: Effective 0901 UTC...) Airspace Docket No. 09-ANM-25, the airspace description for the Lucin VORTAC, Lucin, UT,...

  3. 76 FR 45177 - Establishment of Class E Airspace; Nephi, UT

    Science.gov (United States)

    2011-07-28

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Nephi, UT AGENCY... airspace at Nephi UT, to accommodate aircraft using new Area Navigation (RNAV) Global Positioning System... proposed rulemaking to establish Class E airspace at Nephi, UT (76 FR 28382). Interested parties...

  4. 75 FR 22892 - Environmental Impact Statement: Salt Lake County, UT

    Science.gov (United States)

    2010-04-30

    ... Federal Highway Administration Environmental Impact Statement: Salt Lake County, UT AGENCY: Federal..., UT 84118, telephone (801) 963-0182, e-mail Edward.Woolford@dot.gov . The Utah Department of Transportation (UDOT) contact is Brandon Weston, Project Manager, 2010 South 2760 West, Salt Lake City, UT...

  5. Deployable Integral Field Units, Multislits, and Image Slicer for the Goodman Imaging Spectrograph on the SOAR Telescope

    Science.gov (United States)

    Cecil, Gerald N.; Moffett, A. J.; Cui, Y.; Eckert, K. D.; McBride, J.; Kannappan, S.; Keller, K.; Barlow, B. N.; Dunlap, B.; Bland-Hawthorn, J.

    2010-01-01

    The Goodman Imager-Spectrograph on the 4.1m SOAR telescope has operated on Cerro Pachon, Chile with volume-phase holographic gratings in long-slit mode since its commissioning in 2008. Recently, UNC graduate students played key roles to implement robust upgrades for multi-object spectroscopy that will soon be available to US astronomers through the NOAO time share on SOAR: • Multislits over 3x5 arcmin, generated on PCB solder stencils with exceptional sharpness compared to conventional laser cuts, initially to survey globular clusters for pulsating hot sub-dwarfs • An image slicer to obtain 3 simultaneous parallel spectra 70-arcsec long, 1- or 2-arcsec wide, spanning 320-750 nm to map stellar and gaseous emission and mass over the 1500 galaxies in the RESOLVE survey underway on SOAR • Four integral field units, each composed of 5-arcsec diameter, fused bundles of 0.5-arcsec diameter thin-clad optical fiber, independently deployed over a 10x5 arcmin field targeted by an EMCCD also used for Lucky Imaging. Initially will study aperture effects in single fiber surveys, extragalactic globular clusters, and demonstrate technology prior to deployment on larger telescopes • New wheels supporting a large set of existing narrow-band and Sloan filters • A trombone-style atmospheric dispersion compensator that corrects the full 12-arcmin diameter science field down to 30 deg elevation. Working in UNC's Goodman Laboratory for Astronomical Instrumentation, students employed SolidWorks and ZEMAX to design parts for in-house CAM on CNC machines and a 3D printer. All motors are controlled by LabVIEW as is the SOAR TCS. The deployable IFU axes are controlled by Quicksilver Controls Inc. intelligent servos and $80 model robot (Firgelli Corp.) actuators driven by a PIC-microcontroller and a student designed custom PCB. Upgrades and students were supported by $200K from SOAR Corporation, Research Corporation, NSF, and UNC competitive funds, and NC NASA Space Grant, Sigma Xi

  6. Extrarenal phenotypes of the UT-B knockout mouse.

    Science.gov (United States)

    Yang, Baoxue; Li, Xin; Guo, Lirong; Meng, Yan; Dong, Zixun; Zhao, Xuejian

    2014-01-01

    The urea transporter UT-B is expressed in multiple tissues including erythrocytes, kidney, brain, heart, liver, colon, bone marrow, spleen, lung, skeletal muscle, bladder, prostate, and testis in mammals. Phenotype analysis of UT-B-null mice has confirmed that UT-B deletion results in a urea-selective urine-concentrating defect (see Chap. 9 ). The functional significance of UT-B in extrarenal tissues studied in the UT-B-null mouse is discussed in this chapter. UT-B-null mice present depression-like behavior with urea accumulation and nitric oxide reduction in the hippocampus. UT-B deletion causes a cardiac conduction defect, and TNNT2 and ANP expression changes in the aged UT-B-null heart. UT-B also plays a very important role in protecting bladder urothelium from DNA damage and apoptosis by regulating the urea concentration in urothelial cells. UT-B functional deficiency results in urea accumulation in the testis and early maturation of the male reproductive system. These results show that UT-B is an indispensable transporter involved in maintaining physiological functions in different tissues.

  7. Space Telescope.

    Science.gov (United States)

    National Aeronautics and Space Administration, Huntsville, AL. George C. Marshall Space Flight Center.

    This pamphlet describes the Space Telescope, an unmanned multi-purpose telescope observatory planned for launch into orbit by the Space Shuttle in the 1980s. The unique capabilities of this telescope are detailed, the major elements of the telescope are described, and its proposed mission operations are outlined. (CS)

  8. HIZB UT TAHRIR IN LEBANON: ITS CONTRIBUTIONS TO POLITICAL ISLAM

    Directory of Open Access Journals (Sweden)

    Antonio Alonso Marcos

    2011-04-01

    Full Text Available Hizb ut Tahrir al Islami, the Islamic Liberation Party, is a social movement that is highly active in Europe, Central Asia and the Near East. In Lebanon, one of the few countries in the Arab world where it’s legal (together with Yemen and the United Arab Emirates, this party has refused to take part in elections, but continues to participate actively in the country’s political life through its social movement, which they call a “party”. The party’s vicissitudes in this country, going from illegality to operating freely (though recently it has been placed under suspicion, enables us to draw a series of useful conclusions for the evolution of political Islam in the public life of the Republic of Lebanon in the eastern Mediterranean.

  9. The MaNGA integral field unit fiber feed system for the Sloan 2.5 m telescope

    Energy Technology Data Exchange (ETDEWEB)

    Drory, N. [McDonald Observatory, The University of Texas at Austin, 1 University Station, Austin, TX 78712 (United States); MacDonald, N.; Byler, N. [Department of Astronomy, University of Washington, Box 351580 Seattle, WA 98195 (United States); Bershady, M. A.; Smith, M.; Tremonti, C. A.; Wake, D. A.; Eigenbrot, A.; Jaehnig, K. [Department of Astronomy, University of Wisconsin, 475 N. Charter St., Madison, WI 53706 (United States); Bundy, K. [Kavli Institute for the Physics and Mathematics of The Universe (Kavli IPMU, WPI), Todai Institutes for Advanced Study, The University of Tokyo, Kashiwa, Japan 277-8583 (Japan); Gunn, J. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Law, D. R.; Cherinka, B. [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George St, Toronto, ON M5S 3H4 (Canada); Stoll, R. [C Technologies, Inc., 757 Route 202/206, Bridgewater, NJ 08807 (United States); Yan, R. [Department of Physics and Astronomy, University of Kentucky, Lexington, Kentucky, 40506-0055 (United States); Weijmans, A. M. [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife KY16 9SS (United Kingdom); Cope, F.; Holder, D.; Huehnerhoff, J. [Apache Point Observatory, P.O. Box 59, Sunspot, NM 88349 (United States); Harding, P., E-mail: drory@astro.as.utexas.edu [Department of Astronomy, Case Western Reserve University, Cleveland, OH 44106 (United States); and others

    2015-02-01

    We describe the design, manufacture, and performance of bare-fiber integral field units (IFUs) for the SDSS-IV survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) on the the Sloan 2.5 m telescope at Apache Point Observatory. MaNGA is a luminosity-selected integral-field spectroscopic survey of 10{sup 4} local galaxies covering 360–1030 nm at R∼2200. The IFUs have hexagonal dense packing of fibers with packing regularity of 3 μm (rms), and throughput of 96 ± 0.5% from 350 nm to 1 μm in the lab. Their sizes range from 19 to 127 fibers (3–7 hexagonal layers) using Polymicro FBP 120:132:150 μm core:clad:buffer fibers to reach a fill fraction of 56%. High throughput (and low focal-ratio degradation (FRD)) is achieved by maintaining the fiber cladding and buffer intact, ensuring excellent surface polish, and applying a multi-layer anti-reflection (AR) coating of the input and output surfaces. In operations on-sky, the IFUs show only an additional 2.3% FRD-related variability in throughput despite repeated mechanical stressing during plate plugging (however other losses are present). The IFUs achieve on-sky throughput 5% above the single-fiber feeds used in SDSS-III/BOSS, attributable to equivalent performance compared to single fibers and additional gains from the AR coating. The manufacturing process is geared toward mass-production of high-multiplex systems. The low-stress process involves a precision ferrule with a hexagonal inner shape designed to lead inserted fibers to settle in a dense hexagonal pattern. The ferrule ID is tapered at progressively shallower angles toward its tip and the final 2 mm are straight and only a few microns larger than necessary to hold the desired number of fibers. Our IFU manufacturing process scales easily to accommodate other fiber sizes and can produce IFUs with substantially larger fiber counts. To assure quality, automated testing in a simple and inexpensive system enables complete characterization of

  10. The MaNGA Integral Field Unit Fiber Feed System for the Sloan 2.5 m Telescope

    Science.gov (United States)

    Drory, N.; MacDonald, N.; Bershady, M. A.; Bundy, K.; Gunn, J.; Law, D. R.; Smith, M.; Stoll, R.; Tremonti, C. A.; Wake, D. A.; Yan, R.; Weijmans, A. M.; Byler, N.; Cherinka, B.; Cope, F.; Eigenbrot, A.; Harding, P.; Holder, D.; Huehnerhoff, J.; Jaehnig, K.; Jansen, T. C.; Klaene, M.; Paat, A. M.; Percival, J.; Sayres, C.

    2015-02-01

    We describe the design, manufacture, and performance of bare-fiber integral field units (IFUs) for the SDSS-IV survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) on the the Sloan 2.5 m telescope at Apache Point Observatory. MaNGA is a luminosity-selected integral-field spectroscopic survey of 104 local galaxies covering 360-1030 nm at R˜ 2200. The IFUs have hexagonal dense packing of fibers with packing regularity of 3 μm (rms), and throughput of 96 ± 0.5% from 350 nm to 1 μm in the lab. Their sizes range from 19 to 127 fibers (3-7 hexagonal layers) using Polymicro FBP 120:132:150 μm core:clad:buffer fibers to reach a fill fraction of 56%. High throughput (and low focal-ratio degradation (FRD)) is achieved by maintaining the fiber cladding and buffer intact, ensuring excellent surface polish, and applying a multi-layer anti-reflection (AR) coating of the input and output surfaces. In operations on-sky, the IFUs show only an additional 2.3% FRD-related variability in throughput despite repeated mechanical stressing during plate plugging (however other losses are present). The IFUs achieve on-sky throughput 5% above the single-fiber feeds used in SDSS-III/BOSS, attributable to equivalent performance compared to single fibers and additional gains from the AR coating. The manufacturing process is geared toward mass-production of high-multiplex systems. The low-stress process involves a precision ferrule with a hexagonal inner shape designed to lead inserted fibers to settle in a dense hexagonal pattern. The ferrule ID is tapered at progressively shallower angles toward its tip and the final 2 mm are straight and only a few microns larger than necessary to hold the desired number of fibers. Our IFU manufacturing process scales easily to accommodate other fiber sizes and can produce IFUs with substantially larger fiber counts. To assure quality, automated testing in a simple and inexpensive system enables complete characterization of throughput and

  11. Structure-activity analysis of thiourea analogs as inhibitors of UT-A and UT-B urea transporters.

    Science.gov (United States)

    Esteva-Font, Cristina; Phuan, Puay-Wah; Lee, Sujin; Su, Tao; Anderson, Marc O; Verkman, A S

    2015-05-01

    Small-molecule inhibitors of urea transporter (UT) proteins in kidney have potential application as novel salt-sparing diuretics. The urea analog dimethylthiourea (DMTU) was recently found to inhibit the UT isoforms UT-A1 (expressed in kidney tubule epithelium) and UT-B (expressed in kidney vasa recta endothelium) with IC50 of 2-3 mM, and was shown to have diuretic action when administered to rats. Here, we measured UT-A1 and UT-B inhibition activity of 36 thiourea analogs, with the goal of identifying more potent and isoform-selective inhibitors, and establishing structure-activity relationships. The analog set systematically explored modifications of substituents on the thiourea including alkyl, heterocycles and phenyl rings, with different steric and electronic features. The analogs had a wide range of inhibition activities and selectivities. The most potent inhibitor, 3-nitrophenyl-thiourea, had an IC50 of ~0.2 mM for inhibition of both UT-A1 and UT-B. Some analogs such as 4-nitrophenyl-thiourea were relatively UT-A1 selective (IC50 1.3 vs. 10 mM), and others such as thioisonicotinamide were UT-B selective (IC50>15 vs. 2.8 mM).

  12. The UT 7/8 February 2013 Sila-Nunam Mutual Event and Future Predictions

    Science.gov (United States)

    Benecchi, S. D.; Noll, K. S.; Thirouin, A.; Ryan, E.; Grundy, W. M.; Verbiscer, A.; Doressoundiram, A.; Hestroffer, D.; Beaton, R.; Rabinowitz, D.; Chanover, N.

    2013-01-01

    A superior mutual event of the Kuiper Belt binary system (79360) Sila-Nunam was observed over 15.47 h on UT 7/8 February 2013 by a coordinated effort at four different telescope facilities; it started approximately 1.5 h earlier than anticipated, the duration was approximately 9.5 h (about 10% longer than predicted), and was slightly less deep than predicted. It is the first full event observed for a comparably sized binary Kuiper Belt object. We provide predictions for future events refined by this and other partial mutual event observations obtained since the mutual event season began.

  13. Neutrino telescopes

    CERN Document Server

    Carr, J

    2002-01-01

    This review presents the scientific objectives and status of Neutrino Telescope Projects. The science program of these projects covers: neutrino astronomy, dark matter searches and measurements of neutrino oscillations. The two neutrino telescopes in operation: AMANDA and BAIKAL will be described together with the ANTARES neutrino telescope being built in the Mediterranean. (18 refs).

  14. Space Telescopes

    Science.gov (United States)

    2010-01-01

    Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 166 9. Space telescopes Figure 9.1: Paraboloid telescope. In the following sections, NI...planets nearby a brighter star. Normal-incidence telescopes One-mirror telescope The one-mirror telescope (mostly an off-axis paraboloid ; Figure 9.1) has...rotation of the whole instrument (see SUMER/SOHO, Wilhelm et al (1995) and EIS/Hinode, Culhane et al (2007)). The paraboloid field curvature (Petzval

  15. Functional characterization of mouse urea transporters UT-A2 and UT-A3 expressed in purified Xenopus laevis oocyte plasma membranes.

    Science.gov (United States)

    Maciver, Bryce; Smith, Craig P; Hill, Warren G; Zeidel, Mark L

    2008-04-01

    Urea is a small solute synthesized by many terrestrial organisms as part of the catabolism of protein. In mammals it is transported across cellular membranes by specific urea transporter (UT) proteins that are the products of two separate, but closely related genes, referred to as UT-A and UT-B. Three major UT-A isoforms are found in the kidney, namely UT-A1, UT-A2, and UT-A3. UT-A2 is found in the thin, descending limb of the loop of Henle, whereas UT-A1 and UT-A3 are concentrated in the inner medullary collecting duct. UT-A2 and UT-A3 effectively represent two halves of the whole UT-A gene and, when joined together by 73 hydrophilic amino acids, constitute UT-A1. A biophysical characterization of mouse UT-A2 and UT-A3 was undertaken by expression in Xenopus laevis oocytes and subsequent preparation of highly enriched plasma membrane vesicles for use in stopped-flow fluorometry. Both isoforms were found to be highly specific for urea, and did not permeate water, ammonia, or other molecules closely related to urea (formamide, acetamide, methylurea, and dimethylurea). Single transporter flux rates of 46,000 +/- 10,000 and 59,000 +/- 15,000 (means +/- SE) urea molecules/s/channel for UT-A2 and UT-A3, respectively, were obtained. Overall, the UT-A2 and UT-A3 isoforms appear to have identical functional kinetics.

  16. Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity.

    Science.gov (United States)

    Blessing, Nathan W; Blount, Mitsi A; Sands, Jeff M; Martin, Christopher F; Klein, Janet D

    2008-11-01

    The UT-A1 and UT-A3 urea transporters are expressed in the terminal inner medullary collecting duct (IMCD) and play an important role in the production of concentrated urine. We showed that both hyperosmolarity and vasopressin increase urea permeability in perfused rat terminal IMCDs and that UT-A1 and UT-A3 accumulate in the plasma membrane in response to vasopressin. In this study, we investigated whether hyperosmolarity causes UT-A1 and/or UT-A3 to accumulate in the plasma membrane or represents a complimentary stimulatory pathway. Rat IMCD suspensions were incubated in 450 vs. 900 mosM solutions. We biotinylated the IMCD surface proteins, collected, and analyzed them. Membrane accumulation was assessed by Western blotting of the biotinylated protein pool probed with anti-UT-A1 or anti-UT-A3. We studied the effect of NaCl, urea, and sucrose as osmotic agents. Membrane-associated UT-A1 and UT-A3 increased relative to control levels when either NaCl (UT-A1 increased 37 +/- 6%; UT-A3 increased 46 +/- 13%) or sucrose (UT-A1 increased 81 +/- 13%; UT-A3 increased 60 +/- 8%) was used to increase osmolarity. There was no increase in membrane UT-A1 or UT-A3 when urea was added. Analogously, UT-A1 phosphorylation was increased in NaCl- and sucrose- but not in urea-based hyperosmolar solutions. Hypertonicity also increased UT-A3 phosphorylation. We conclude that the increase in the urea permeability in response to hyperosmolarity reflects both UT-A1 and UT-A3 movement to the plasma membrane and may be a direct response to tonicity. Furthermore, this movement is accompanied by, and may require, increased phosphorylation in response to hypertonicity.

  17. Ubiquitination regulates the plasma membrane expression of renal UT-A urea transporters.

    Science.gov (United States)

    Stewart, Gavin S; O'Brien, Jennifer H; Smith, Craig P

    2008-07-01

    The renal UT-A urea transporters UT-A1, UT-A2, and UT-A3 are known to play an important role in the urinary concentrating mechanism. The control of the cellular localization of UT-A transporters is therefore vital to overall renal function. In the present study, we have investigated the effect of ubiquitination on UT-A plasma membrane expression in Madin-Darby canine kidney (MDCK) cell lines expressing each of the three renal UT-A transporters. Inhibition of the ubiquitin-proteasome pathway caused an increase in basal transepithelial urea flux across MDCK-rat (r)UT-A1 and MDCK-mouse (m)UT-A2 monolayers (P UT-A transporter expression in the plasma membrane (P UT-A3 expression in the plasma membrane (P UT-A urea transporters, but that this is not the mechanism primarily used by vasopressin to produce its physiological effects.

  18. Configurable slit-mask unit of the Multi-Object Spectrometer for Infra-Red Exploration for the Keck telescope: integration and tests

    Science.gov (United States)

    Spanoudakis, Peter; Giriens, Laurent; Henein, Simon; Lisowski, Leszek; O'Hare, Aidan; Onillon, Emmanuel; Schwab, Philippe; Theurillat, Patrick

    2008-07-01

    A Configurable Slit Unit (CSU) has been developed for the Multi-Object Spectrometer for Infra-Red Exploration (MOSFIRE) instrument to be installed on the Keck 1 Telescope on Mauna Kea, Hawaii. MOSFIRE will provide NIR multi-object spectroscopy over a field of view of 6.1' x 6.1'. The reconfigurable mask allows the formation of 46 optical slits in a 267 x 267 mm2 field of view. The mechanism is an evolution of a former prototype designed by CSEM and qualified for the European Space Agency (ESA) as a candidate for the slit mask on NIRSpec for the James Webb Space Telescope (JWST). The CSU is designed to simultaneously displace masking bars across the field-of-view (FOV) to mask unwanted light. A set of 46 bar pairs are used to form the MOSFIRE focal plane mask. The sides of the bars are convoluted so that light is prevented from passing between adjacent bars. The slit length is fixed (5.1 mm) but the width is variable down to 200 μm with a slit positioning accuracy of +/- 18 μm. A two-bar prototype mechanism was designed, manufactured and cryogenically tested to validate the modifications from the JWST prototype. The working principle of the mechanism is based on an improved "inch-worm" stepping motion of 92 masking bars forming the optical mask. Original voice coil actuators are used to drive the various clutches. The design makes significant use of flexure structures.

  19. Design and development of control unit and software for the ADFOSC instrument of the 3.6 m Devasthal optical telescope

    Science.gov (United States)

    Kumar, T. S.

    2016-08-01

    In this paper, we describe the details of control unit and GUI software for positioning two filter wheels, a slit wheel and a grism wheel in the ADFOSC instrument. This is a first generation instrument being built for the 3.6 m Devasthal optical telescope. The control hardware consists of five electronic boards based on low cost 8-bit PIC microcontrollers and are distributed over I2C bus. The four wheels are controlled by four identical boards which are configured in I2C slave mode while the fifth board acts as an I2C master for sending commands to and receiving status from the slave boards. The master also communicates with the interfacing PC over TCP/IP protocol using simple ASCII commands. For moving the wheels stepper motors along with suitable amplifiers have been employed. Homing after powering ON is achieved using hall effect sensors. By implementing distributed control units having identical design modularity is achieved enabling easier maintenance and upgradation. A GUI based software for commanding the instrument is developed in Microsoft Visual C++. For operating the system during observations the user selects normal mode while the engineering mode is available for offering additional flexibility and low level control during maintenance and testing. A detailed time-stamped log of commands, status and errors are continuously generated. Both the control unit and the software have been successfully tested and integrated with the ADFOSC instrument.

  20. MEGARA optical design: the new integral field unit and multi-object spectrograph for the GTC 10m telescope

    Science.gov (United States)

    García-Vargas, María. Luisa; Sánchez-Blanco, Ernesto; Carrasco, Esperanza; Gil de Paz, Armando; Páez, Gonzalo; Pérez, Ana; Gallego, Jesús; Sánchez, Francisco; Vílchez, José M.

    2012-12-01

    We describe the optical design of MEGARA, the future optical Integral Field Unit (IFU) and Multi-Object Spectrograph (MOS) for the 10.4-m Gran Telescopio CANARIAS (GTC). MEGARA is being built by a Consortium of public research institutions led by the Universidad Complutense de Madrid (UCM, Spain) that also includes INAOE (Mexico), IAA-CSIC (Spain) and UPM (Spain).

  1. SNAP telescope

    Energy Technology Data Exchange (ETDEWEB)

    Lampton, Michael L.; Akerlof, C.W.; Aldering, G.; Amanullah, R.; Astier, P.; Barrelet, E.; Bebek, C.; Bergstrom, L.; Bercovitz, J.; Bernstein, G.; Bester, M.; Bonissent, A.; Bower, C.; Carithers Jr., W.C.; Commins, E.D.; Day, C.; Deustua, S.E.; DiGennaro, R.; Ealet, A.; Ellis,R.S.; Eriksson, M.; Fruchter, A.; Genat, J.-F.; Goldhaber, G.; Goobar,A.; Groom, D.; Harris, S.E.; Harvey, P.R.; Heetderks, H.D.; Holland,S.E.; Huterer, D.; Karcher, A.; Kim, A.G.; Kolbe, W.; Krieger, B.; Lafever, R.; Lamoureux, J.; Levi, M.E.; Levin, D.S.; Linder, E.V.; Loken,S.C.; Malina, R.; Massey, R.; McKay, T.; McKee, S.P.; Miquel, R.; Mortsell, E.; Mostek, N.; Mufson, S.; Musser, J.; Nugent, P.; Oluseyi,H.; Pain, R.; Palaio, N.; Pankow, D.; Perlmutter, S.; Pratt, R.; Prieto,E.; Refregier, A.; Rhodes, J.; Robinson, K.; Roe, N.; Sholl, M.; Schubnell, M.; Smadja, G.; Smoot, G.; Spadafora, A.; Tarle, G.; Tomasch,A.; von der Lippe, H.; Vincent, R.; Walder, J.-P.; Wang, G.; Wang, G.

    2002-07-29

    The SuperNova/Acceleration Probe (SNAP) mission will require a two-meter class telescope delivering diffraction limited images spanning a one degree field in the visible and near infrared wavelength regime. This requirement, equivalent to nearly one billion pixel resolution, places stringent demands on its optical system in terms of field flatness, image quality, and freedom from chromatic aberration. We discuss the advantages of annular-field three-mirror anastigmat (TMA) telescopes for applications such as SNAP, and describe the features of the specific optical configuration that we have baselined for the SNAP mission. We discuss the mechanical design and choice of materials for the telescope. Then we present detailed ray traces and diffraction calculations for our baseline optical design. We briefly discuss stray light and tolerance issues, and present a preliminary wavefront error budget for the SNAP Telescope. We conclude by describing some of tasks to be carried out during the upcoming SNAP research and development phase.

  2. A UT/LS ozone climatology of the nineteen seventies deduced from the GASP aircraft measurement program

    Directory of Open Access Journals (Sweden)

    C. Schnadt Poberaj

    2007-03-01

    Full Text Available The knowledge of historical ozone in the upper troposphere/lower stratosphere (UT/LS region is mostly confined to regular measurements from a number of ozonesonde stations. We present ozone measurements of the Global Atmospheric Sampling Program (GASP performed from four commercial and one research aircraft during 1975 to 1979. Using GASP data, a UT/LS ozone climatology of 1975–1979 was built. Seasonality and concentrations of GASP UT ozone in the middle, subtropical and tropical regions of the northern hemisphere (NH are generally in agreement with other published observations, derived from ozonesondes or aircraft campaigns. In regions where both GASP (1970s and MOZAIC (1990s data are available, similar ozone concentrations are found and seasonal cycles agree well confirming the reliability of GASP ozone. GASP provides unique large-scale climatological information on UT/LS ozone above the NH Pacific region. Agreement is found with observations from individual ozonesonde sites and aircraft campaigns carried out over this region. Tropical UT ozone is seen to be lower near the dateline than further east, presumably related to uplift of ozone poor air within convection. Over the west coast of the United States, summer UT ozone is higher than over the adjacent Pacific, probably caused by air pollution over southern California in the 1970s. GASP offers an unprecedented opportunity to link to European, Canadian and U.S. American ozonesonde observations of the 1970s. For the quantitative comparison, an altitude offset was applied to the sonde data to account for the slow response time of the sensors. In the LS, the European and Canadian Brewer-Mast (BM sensors then agree to ±10% with the GASP instruments in all seasons. In the UT, the European BM sondes record similar to slightly less average ozone than GASP, however, with large variability overlaid. Over the eastern United States, systematic positive deviations of the Wallops Island ECC sondes from

  3. 76 FR 28074 - Notice of Inventory Completion: Utah Museum of Natural History, Salt Lake City, UT

    Science.gov (United States)

    2011-05-13

    ... National Park Service Notice of Inventory Completion: Utah Museum of Natural History, Salt Lake City, UT... City, UT. The human remains were removed from Snow Canyon State Park, Washington County, UT. This... individual were removed from Snow Canyon State Park, Washington County, UT, by hikers and reposited...

  4. BREAKOUT RECONNECTION OBSERVED BY THE TESIS EUV TELESCOPE

    Energy Technology Data Exchange (ETDEWEB)

    Reva, A. A.; Ulyanov, A. S.; Shestov, S. V.; Kuzin, S. V., E-mail: reva.antoine@gmail.com [Lebedev Physical Institute, Russian Academy of Sciences (Russian Federation)

    2016-01-10

    We present experimental evidence of the coronal mass ejection (CME) breakout reconnection, observed by the TESIS EUV telescope. The telescope could observe solar corona up to 2 R{sub ⊙} from the Sun center in the Fe 171 Å line. Starting from 2009 April 8, TESIS observed an active region (AR) that had a quadrupolar structure with an X-point 0.5 R{sub ⊙} above photosphere. A magnetic field reconstructed from the Michelson Doppler Imager data also has a multipolar structure with an X-point above the AR. At 21:45 UT on April 9, the loops near the X-point started to move away from each other with a velocity of ≈7 km s{sup −1}. At 01:15 UT on April 10, a bright stripe appeared between the loops, and the flux in the GOES 0.5–4 Å channel increased. We interpret the loops’ sideways motion and the bright stripe as evidence of the breakout reconnection. At 01:45 UT, the loops below the X-point started to slowly move up. At 15:10 UT, the CME started to accelerate impulsively, while at the same time a flare arcade formed below the CME. After 15:50 UT, the CME moved with constant velocity. The CME evolution precisely followed the breakout model scenario.

  5. Breakout Reconnection Observed by the TESIS EUV Telescope

    Science.gov (United States)

    Reva, A. A.; Ulyanov, A. S.; Shestov, S. V.; Kuzin, S. V.

    2016-01-01

    We present experimental evidence of the coronal mass ejection (CME) breakout reconnection, observed by the TESIS EUV telescope. The telescope could observe solar corona up to 2 R⊙ from the Sun center in the Fe 171 Å line. Starting from 2009 April 8, TESIS observed an active region (AR) that had a quadrupolar structure with an X-point 0.5 R⊙ above photosphere. A magnetic field reconstructed from the Michelson Doppler Imager data also has a multipolar structure with an X-point above the AR. At 21:45 UT on April 9, the loops near the X-point started to move away from each other with a velocity of ≈7 km s-1. At 01:15 UT on April 10, a bright stripe appeared between the loops, and the flux in the GOES 0.5-4 Å channel increased. We interpret the loops’ sideways motion and the bright stripe as evidence of the breakout reconnection. At 01:45 UT, the loops below the X-point started to slowly move up. At 15:10 UT, the CME started to accelerate impulsively, while at the same time a flare arcade formed below the CME. After 15:50 UT, the CME moved with constant velocity. The CME evolution precisely followed the breakout model scenario.

  6. KOALA: a wide-field 1000 element integral-field unit for the Anglo-Australian Telescope

    Science.gov (United States)

    Ellis, S. C.; Ireland, M.; Lawrence, J. S.; Tims, J.; Staszak, N.; Brzeski, J.; Parker, Q. A.; Sharp, R.; Bland-Hawthorn, J.; Case, S.; Colless, M.; Croom, S.; Couch, W.; De Marco, O.; Glazebrook, K.; Saunders, W.; Webster, R.; Zucker, D. B.

    2012-09-01

    KOALA, the Kilofibre Optimised Astronomical Lenslet Array, is a wide-field, high efficiency integral field unit being designed for use with the bench mounted AAOmega spectrograph on the AAT. KOALA will have 1000 fibres in a rectangular array with a selectable field of view of either 1390 or 430 sq. arcseconds with a spatial sampling of 1.25" or 0.7" respectively. To achieve this KOALA will use a telecentric double lenslet array with interchangeable fore-optics. The IFU will feed AAOmega via a 31m fibre run. The efficiency of KOALA is expected to be ≍ 52% at 3700A and ≍ 66% at 6563°Å with a throughput of > 52% over the entire wavelength range.

  7. The science case of WISH-Spec, an Integral-field unit for the WISH telescope to study the first populations of galaxies in the universe

    Science.gov (United States)

    Burgarella, Denis

    2015-08-01

    WISH is a new space science mission concept whose primary goal is to study the first galaxies in the early universe. WISH will be a 1.5m telescope equipped with a 1000 arcmin2 wide-field Near-IR camera that would fly in ~2020 in order to conduct unique ultra-deep and wide-area sky surveys in the wavelength range 1-5 micron. A spectroscopic mode (Integral-Field Unit) in the same Near-IR range is also planned. The primary science goal of WISH mission is to push the high-redshift frontier beyond the epoch of reionization by utilizing its unique imaging capability and the dedicated survey strategy. Which spectral range should we select to optimize the detection of very high-redshift (i.e., z > 5) galaxies ? In the rest-frame Far-UV or in the rest-frame Far-IR? In a recent paper, Burgarella et al. (2013) showed that the Far-UV dust attenuation (AFUV) reaches the same level at z ~ 3 than at z = 0 . This suggest that the early universe would be better studied in the rest-frame Far-UV. At z > 5, this Far-UV range moves into the Near-IR (1 - 5um) which is WISH’s preferred spectral range. The baseline of WISH-Spec is a 1x1 arcmin2 Integral-Field Unit (IFU) using slicers. WISH-Spec could observe in a parallel mode which translates into spectroscopic exposure times as long as the telescope lifetime. WISH features two 100-deg2 and 1000-deg2 surveys. However, WISHSpec will allow to acquire very large samples of high-redshift and primordial galaxies by combining spectroscopic detections within total (non contiguous) 1-deg2 and 10-deg2 fields of views. Therefore, the first strong advantage of WISHSpec wrt JWST is that 10^4 - 10^5 faint emission-line galaxies in 1 deg2 and 10^3 - 10^6 bright emission-line galaxies in 10 deg2 in the redshift range 3 < z < 8 will be detected.

  8. Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane.

    Science.gov (United States)

    Feng, Xiuyan; Huang, Haidong; Yang, Yuan; Fröhlich, Otto; Klein, Janet D; Sands, Jeff M; Chen, Guangping

    2009-06-01

    The cell plasma membrane contains specialized microdomains called lipid rafts which contain high amounts of sphingolipids and cholesterol. Lipid rafts are involved in a number of membrane protein functions. The urea transporter UT-A1, located in the kidney inner medullary collecting duct (IMCD), is important for urine concentrating ability. In this study, we investigated the possible role of lipid rafts in UT-A1 membrane regulation. Using sucrose gradient cell fractionation, we demonstrated that UT-A1 is concentrated in the caveolae-rich fraction both in stably expressing UT-A1 HEK293 cells and in freshly isolated kidney IMCD suspensions. In these gradients, UT-A1 at the cell plasma membrane is codistributed with caveolin-1, a major component of caveolae. The colocalization of UT-A1 in lipid rafts/caveolae was further confirmed in isolated caveolae from UT-A1-HEK293 cells. The direct association of UT-A1 and caveolin-1 was identified by immunoprecipitation and GST pull-down assay. Examination of internalized UT-A1 in pEGFP-UT-A1 transfected HEK293 cells fluorescent overlap with labeled cholera toxin subunit B, a marker of the caveolae-mediated endocytosis pathway. Disruption of lipid rafts by methyl-beta-cyclodextrin or knocking down caveolin-1 by small-interference RNA resulted in UT-A1 cell membrane accumulation. Functionally, overexpression of caveolin-1 in oocytes decreased UT-A1 urea transport activity and UT-A1 cell surface expression. Our results indicate that lipid rafts/caveolae participate in UT-A1 membrane regulation and this effect is mediated via a direct interaction of caveolin-1 with UT-A1.

  9. Selecting Your First Telescope.

    Science.gov (United States)

    Harrington, Sherwood

    1982-01-01

    Designed for first-time telescope purchasers, provides information on how a telescope works; major telescope types (refractors, reflectors, compound telescopes); tripod, pier, altazimuth, and equatorial mounts; selecting a telescope; visiting an astronomy club; applications/limitations of telescope use; and tips on buying a telescope. Includes a…

  10. Urearetics: a small molecule screen yields nanomolar potency inhibitors of urea transporter UT-B.

    Science.gov (United States)

    Levin, Marc H; de la Fuente, Ricardo; Verkman, A S

    2007-02-01

    Functional studies in knockout mice indicate a critical role for urea transporters (UTs) in the urinary concentrating mechanism and in renal urea clearance. However, potent and specific urea transport blockers have not been available. Here, we used high-throughput screening to discover high-affinity, small molecule inhibitors of the UT-B urea transporter. A collection of 50,000 diverse, drug-like compounds was screened using a human erythrocyte lysis assay based on UT-B-facilitated acetamide transport. Primary screening yielded approximately 30 UT-B inhibitors belonging to the phenylsulfoxyoxazole, benzenesulfonanilide, phthalazinamine, and aminobenzimidazole chemical classes. Screening of approximately 700 structurally similar analogs gave many active compounds, the most potent of which inhibited UT-B urea transport with an EC50 of approximately 10 nM, and approximately 100% inhibition at higher concentrations. Phenylsulfoxyoxazoles and phthalazinamines also blocked rodent UT-B and had good UT-B vs. UT-A specificity. The UT-B inhibitors did not reduce aquaporin-1 (AQP1)-facilitated water transport. In AQP1-null erythrocytes, "chemical UT-B knockout" by UT-B inhibitors reduced by approximately 3-fold UT-B-mediated water transport, supporting an aqueous pore pathway through UT-B. UT-B inhibitors represent a new class of diuretics, "urearetics," which are predicted to increase renal water and solute clearance in water-retaining states.

  11. Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.

    Science.gov (United States)

    Su, Hua; Carter, Conner B; Laur, Oskar; Sands, Jeff M; Chen, Guangping

    2012-11-01

    The adenylyl cyclase stimulator forskolin (FSK) stimulates UT-A1 phosphorylation, membrane trafficking, and urea transport activity. Here, we found that FSK stimulation induces UT-A1 ubiquitination in UT-A1 Madin-Darby canine kidney (MDCK) cells. This suggests that phosphorylation by FSK also triggers the protein degradation machinery for UT-A1. UT-A1-MDCK cells were treated with 100 μg/ml cycloheximide to inhibit protein synthesis, with or without 10 μM FSK. Total UT-A1 protein abundance was significantly reduced after FSK treatment, concomitantly ubiquitinated UT-A1 was increased. We then specifically investigated the effect of FSK on UT-A1 expressed on the cell plasma membrane. FSK treatment accelerated UT-A1 removal from the cell plasma membrane by increasing UT-A1 endocytosis as judged by biotinylation/MesNa treatment and confocal microscopy. We further found that inhibition of the clathrin-mediated endocytic pathway, but not the caveolin-mediated endocytic pathway, significantly blocks FSK-stimulated UT-A1 endocytosis. The PKA inhibitor H89 and the proteasome inhibitors MG132 and lactacystin reduced FSK-induced membrane UT-A1 reduction. Our study shows that FSK activates the UT-A1 urea transporter and the activation/phosphorylation subsequently triggers the downregulation of UT-A1, which represents an important mechanism for the cell to return to the basal conditions after vasopressin stimulation.

  12. RadNet Air Data From Salt Lake City, UT

    Science.gov (United States)

    This page presents radiation air monitoring and air filter analysis data for Salt Lake City, UT from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  13. 76 FR 79112 - Radio Broadcasting Services; Milford, UT

    Science.gov (United States)

    2011-12-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Milford, UT AGENCY: Federal Communications Commission. ACTION: Final Rule. SUMMARY: The Audio Division, at the request of Canyon Media Group, LLC, allots...

  14. A Scientific Trigger Unit for Space-Based Real-Time Gamma Ray Burst Detection, II - Data Processing Model and Benchmarks

    CERN Document Server

    Provost, Hervé Le; Flouzat, Christophe; Kestener, Pierre; Chaminade, Thomas; Donati, Modeste; Château, Frédéric; Daly, François; Fontignie, Jean

    2014-01-01

    The Scientific Trigger Unit (UTS) is a satellite equipment designed to detect Gamma Ray Bursts (GRBs) observed by the onboard 6400 pixels camera ECLAIRs. It is foreseen to equip the low-Earth orbit French-Chinese satellite SVOM and acts as the GRB trigger unit for the mission. The UTS analyses in real-time and in great details the onboard camera data in order to select the GRBs, to trigger a spacecraft slew re-centering each GRB for the narrow field-of-view instruments, and to alert the ground telescope network for GRB follow-up observations. A few GRBs per week are expected to be observed by the camera; the UTS targets a close to 100% trigger efficiency, while being selective enough to avoid fake alerts. This is achieved by running the complex scientific algorithms on a radiation tolerant hardware, based on a FPGA data pre-processor and a CPU with a Real-Time Operating System. The UTS is a scientific software, firmware and hardware co-development. A Data Processing Model (DPM) has been developed to fully val...

  15. Hvad enhver kordreng skal kunne. Betragtning af motetten Ut Phebi radiis af Josquin Desprez

    DEFF Research Database (Denmark)

    Christoffersen, Peter Woetmann

    2003-01-01

    Josquin Desprez, Ut Phebi radiis, motet, prayer mode, hexachord, Ockeghem, Brumel, Isaac, Compère, sound, udtryk......Josquin Desprez, Ut Phebi radiis, motet, prayer mode, hexachord, Ockeghem, Brumel, Isaac, Compère, sound, udtryk...

  16. Breakout Reconnection Observed by the TESIS EUV Telescope

    CERN Document Server

    Reva, Anton; Shestov, Sergey; Kuzin, Sergey

    2016-01-01

    We present experimental evidence of the coronal mass ejection (CME) breakout reconnection, observed by the TESIS EUV telescope. The telescope could observe solar corona up to 2 $R_\\odot$ from the Sun center in the Fe 171 \\AA\\ line. Starting from 2009 April 8 TESIS, observed an active region (AR) that had a quadrupolar structure with an X-point 0.5 $R_\\odot$ above photosphere. A reconstructed from the MDI data magnetic field also has a multipolar structure with an X-point above the AR. At 21:45 UT on April 9, the loops near the X-point started to move away from each other with a velocity of $\\approx$ 7 km s$^{-1}$. At 01:15 UT on April 10, a bright stripe appeared between the loops, and the flux in the GOES 0.5-4 \\AA\\ channel increased. We interpret the loops' sideways motion and the bright stripe as evidence of the breakout reconnection. At 01:45 UT, the loops below the X-point started to slowly move up. At 15:10 UT, the CME started to accelerate impulsively, while at the same time a flare arcade formed below...

  17. El Ocaso de la Ciudad Utópica

    Directory of Open Access Journals (Sweden)

    Rodrigo Castro Orellana

    2009-10-01

    Full Text Available Se analiza, en primer lugar, la representación del espacio urbano que se articula en algunos de los relatos utópicos clásicos (Moro, Campanella. En estos escritos nos encontramos ante una propuesta de sociedad ideal como expresión de la voluntad ordenadora de la razón humana que se enfrenta a la naturaleza y que apuesta por la edificación de un futuro mejor. En este contexto, las ciudades soñadas por las utopías deben considerarse como esbozos imaginarios de un concepto de construcción real que determinó significativamente buena parte de la modernidad urbana. Dicha voluntad utópica ha sufrido un importante resquebrajamiento a partir de la segunda mitad del Siglo XX, como lo testimonian una serie de relatos contra-utópicos en la literatura (Orwell, Huxley o Dick y, sobre todo, en la cinematografía reciente (Blade Runner, Brazil o Matrix. Este desplazamiento en el diseño de las ciudades del futuro trae consigo una inversión en los códigos del discurso utópico, que sería fiel reflejo de la experiencia contemporánea del sujeto en el espacio urbano y consecuencia del desarrollo y la crisis de la modernidad occidental. Todo esto implica, además, una mutación decisiva en la noción de futuro que afectaría sustancialmente a nuestra civilización de principios del Siglo XXI.

  18. El Ocaso de la Ciudad Utópica

    Directory of Open Access Journals (Sweden)

    Rodrigo Castro Orellana

    2009-10-01

    Full Text Available Se analiza, en primer lugar, la representación del espacio urbano que se articula en algunos de los relatos utópicos clásicos (Moro, Campanella. En estos escritos nos encontramos ante una propuesta de sociedad ideal como expresión de la voluntad ordenadora de la razón humana que se enfrenta a la naturaleza y que apuesta por la edificación de un futuro mejor. En este contexto, las ciudades soñadas por las utopías deben considerarse como esbozos imaginarios de un concepto de construcción real que determinó significativamente buena parte de la modernidad urbana. Dicha voluntad utópica ha sufrido un importante resquebrajamiento a partir de la segunda mitad del Siglo XX, como lo testimonian una serie de relatos contra-utópicos en la literatura (Orwell, Huxley o Dick y, sobre todo, en la cinematografía reciente (Blade Runner, Brazil o Matrix. Este desplazamiento en el diseño de las ciudades del futuro trae consigo una inversión en los códigos del discurso utópico, que sería fiel reflejo de la experiencia contemporánea del sujeto en el espacio urbano y consecuencia del desarrollo y la crisis de la modernidad occidental. Todo esto implica, además, una mutación decisiva en la noción de futuro que afectaría sustancialmente a nuestra civilización de principios del Siglo XXI.

  19. A UT positioning approach for dynamic satellite constellations

    Science.gov (United States)

    Zhao, W.; Tafazolli, R.; Evans, B. G.

    1995-01-01

    In this paper, we discuss a new positioning scheme which is thought to be applicable for dynamic satellite constellations. We begin with the introduction of our filter model which is based on stochastic process and filtering theory. Then, simulation results of the technique are presented based on a LEO constellation and some of the IRIDIUM system parameters. Performance of this algorithm is investigated under various noise conditions. Finally, several applications of this UT (user terminal) positioning algorithm are discussed.

  20. A small molecule screen identifies selective inhibitors of urea transporter UT-A.

    Science.gov (United States)

    Esteva-Font, Cristina; Phuan, Puay-Wah; Anderson, Marc O; Verkman, A S

    2013-10-24

    Urea transporter (UT) proteins, including UT-A in kidney tubule epithelia and UT-B in vasa recta microvessels, facilitate urinary concentrating function. A screen for UT-A inhibitors was developed in MDCK cells expressing UT-A1, water channel aquaporin-1, and YFP-H148Q/V163S. An inwardly directed urea gradient produces cell shrinking followed by UT-A1-dependent swelling, which was monitored by YFP-H148Q/V163S fluorescence. Screening of ~90,000 synthetic small molecules yielded four classes of UT-A1 inhibitors with low micromolar half-maximal inhibitory concentration that fully and reversibly inhibited urea transport by a noncompetitive mechanism. Structure-activity analysis of >400 analogs revealed UT-A1-selective and UT-A1/UT-B nonselective inhibitors. Docking computations based on homology models of UT-A1 suggested inhibitor binding sites. UT-A inhibitors may be useful as diuretics ("urearetics") with a mechanism of action that may be effective in fluid-retaining conditions in which conventional salt transport-blocking diuretics have limited efficacy.

  1. 75 FR 44727 - Proposed Revocation and Establishment of Class E Airspace; St. George, UT

    Science.gov (United States)

    2010-07-29

    ... Airspace; St. George, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., St. George, UT, as the airport will be closing, eliminating the need for controlled airspace. This... Instrument Approach Procedures (SIAPs) at the new St. George Municipal Airport, St. George, UT. The FAA...

  2. 75 FR 62461 - Revocation and Establishment of Class E Airspace; St. George, UT

    Science.gov (United States)

    2010-10-12

    .... George, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action will remove Class E airspace at St. George, UT, as the airport will be closing, eliminating the need... Municipal Airport, St. George, UT (75 FR 44727). Interested parties were invited to participate in...

  3. 75 FR 63730 - Proposed Establishment of Class E Airspace; Panguitch, UT

    Science.gov (United States)

    2010-10-18

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Panguitch, UT... Airport, Panguitch, UT. In an NPRM published in the Federal Register June 28, 2010, the FAA proposed to... Airport, Panguitch, UT (75 FR 36585). The comment period closed August 12, 2010. Two comments...

  4. 78 FR 41336 - Proposed Establishment of Class E Airspace; Wasatch, UT

    Science.gov (United States)

    2013-07-10

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Wasatch, UT... Tactical Air Navigational Aid (VORTAC) navigation aid, Wasatch, UT, to facilitate vectoring of Instrument... navigation aid, Wasatch, UT. This action would contain aircraft while in IFR conditions under control of...

  5. 78 FR 2430 - Notice of Inventory Completion: Natural History Museum of Utah, Salt Lake City, UT

    Science.gov (United States)

    2013-01-11

    ... National Park Service Notice of Inventory Completion: Natural History Museum of Utah, Salt Lake City, UT... City, UT 84108, telephone (801) 581-3876. SUPPLEMENTARY INFORMATION: Notice is here given in accordance... Utah counties, UT. This notice is published as part of the National Park Service's...

  6. MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation.

    Science.gov (United States)

    Chen, Guangping; Huang, Haidong; Fröhlich, Otto; Yang, Yuan; Klein, Janet D; Price, S Russ; Sands, Jeff M

    2008-11-01

    UT-A1 is the primary urea transporter in the apical plasma membrane responsible for urea reabsorption in the inner medullary collecting duct. Although the physiological function of UT-A1 has been well established, the molecular mechanisms that regulate its activity are less well understood. Analysis of the UT-A1 amino acid sequence revealed a potential MDM2 E3 ubiquitin ligase-binding motif in the large intracellular loop of UT-A1, suggesting that UT-A1 urea transporter protein may be regulated by the ubiquitin-proteasome pathway. Here, we report that UT-A1 is ubiquitinated and degraded by the proteasome but not the lysosome proteolytic pathway. Inhibition of proteasome activity causes UT-A1 cell surface accumulation and concomitantly increases urea transport activity. UT-A1 interacts directly with MDM2; the binding site is located in the NH2-terminal p53-binding region of MDM2. MDM2 mediates UT-A1 ubiquitination both in vivo and in vitro. Overexpression of MDM2 promotes UT-A1 degradation. The mechanism is likely to be physiologically important as UT-A1 ubiquitination was identified in kidney inner medullary tissue. The ubiquitin-proteasome degradation pathway provides an important novel mechanism for UT-A1 regulation.

  7. 75 FR 39147 - Establishment of Class E Airspace; Bryce Canyon, UT

    Science.gov (United States)

    2010-07-08

    ... Federal Aviation Administration 14 CFR Part 71 Establishment of Class E Airspace; Bryce Canyon, UT AGENCY... E airspace at Bryce Canyon, UT, to accommodate aircraft using a new Area Navigation (RNAV) Global... Bryce Canyon, UT (74 FR 59492). The comments received prompted the FAA on April 26, 2010, to publish...

  8. 75 FR 3955 - Environmental Impact Statement: Davis and Weber Counties, UT

    Science.gov (United States)

    2010-01-25

    ... Federal Highway Administration Environmental Impact Statement: Davis and Weber Counties, UT AGENCY... West 4700 South, Suite 9A, Salt Lake City, UT 84118, Telephone: (801) 963-0182, E-mail: Edward.Woolford... Randy Jefferies, Project Manager, 166 Southwell Street, Ogden, UT 84404, Telephone: (801) 620-1690,...

  9. 78 FR 19519 - Notice of Invitation to Participate; Coal Exploration License Application UTU-89454, UT

    Science.gov (United States)

    2013-04-01

    ...-89454, UT AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Pursuant to the Mineral... public room of the BLM Utah State Office, 440 West 200 South, Suite 500, Salt Lake City, UT 84101. The... 200 South, Suite 500, Salt Lake City, UT 84101 and Ark Land Company, c/o Sufco Mine, Attn:...

  10. 75 FR 14383 - Proposed Establishment of Class E Airspace; Lucin, UT

    Science.gov (United States)

    2010-03-25

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Lucin, UT... Tactical Air Navigational Aid (VORTAC), Lucin, UT, to facilitate ] vectoring of Instrument Flight Rules (IFR) traffic from en route airspace to Salt Lake City, UT. This action would enhance the safety...

  11. 78 FR 63380 - Amendment of Class E Airspace; St. George, UT

    Science.gov (United States)

    2013-10-24

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; St. George, UT AGENCY... airspace at St. George Municipal Airport, St. George, UT, by removing the operating hours established by a... Federal Register a notice of proposed rulemaking (NPRM) to amend controlled airspace at St. George, UT...

  12. 78 FR 45473 - Proposed Amendment of Class E Airspace; St. George, UT

    Science.gov (United States)

    2013-07-29

    ... Proposed Amendment of Class E Airspace; St. George, UT AGENCY: Federal Aviation Administration (FAA), DOT... St. George Municipal Airport, St. George, UT, by removing the operating hours established by a Notice... Airport, St. George, UT. DATES: Comments must be received on or before September 12, 2013. ADDRESSES:...

  13. 78 FR 27872 - Proposed Amendment of Class E Airspace; Salt Lake City, UT

    Science.gov (United States)

    2013-05-13

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Salt Lake City, UT..., UT. Controlled airspace is necessary to accommodate aircraft using Area Navigation (RNAV) Global..., Salt Lake City, UT to accommodate aircraft using RNAV (GPS) and ILS or LOC standard instrument...

  14. 78 FR 49116 - Modification of Class E Airspace; Brigham City, UT

    Science.gov (United States)

    2013-08-13

    ... Federal Aviation Administration 14 CFR Part 71 Modification of Class E Airspace; Brigham City, UT AGENCY... airspace at Brigham City Airport, Brigham City, UT. Decommissioning of the Brigham City Nondirectional... modify controlled airspace at Brigham City, UT (78 FR 33772). Interested parties were invited...

  15. 75 FR 36585 - Proposed Establishment of Class E Airspace; Panguitch, UT

    Science.gov (United States)

    2010-06-28

    ...; Panguitch, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking..., Panguitch UT. Controlled airspace is necessary to accommodate aircraft using a new Area Navigation (RNAV... airspace at Panguitch Municipal Airport, Panguitch UT. Controlled airspace extending upward from 700...

  16. 78 FR 45848 - Amendment of Class E Airspace; Salt Lake City, UT

    Science.gov (United States)

    2013-07-30

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Salt Lake City, UT AGENCY... airspace at Salt Lake City, UT, to accommodate aircraft using Area Navigation (RNAV) Global Positioning... feet above the surface, at Salt Lake City, UT. DATES: Effective date, 0901 UTC, October 17, 2013....

  17. 75 FR 21532 - Proposed Establishment of Class E Airspace; Bryce Canyon, UT

    Science.gov (United States)

    2010-04-26

    ..., UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Supplemental notice of proposed... surface airspace at Bryce Canyon Airport, Bryce Canyon, UT. In a NPRM published in the Federal Register... Airport, Bryce Canyon, UT (74 FR 59492). The comment period closed January 4, 2010. Two comments...

  18. 76 FR 28382 - Proposed Establishment of Class E Airspace; Nephi, UT

    Science.gov (United States)

    2011-05-17

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Nephi, UT...: This action proposes to establish Class E airspace at Nephi Municipal Airport, Nephi, UT. Controlled... (GPS) standard instrument approach procedures at Nephi Municipal Airport, Nephi, UT. The FAA...

  19. 76 FR 14802 - Modification of Class E Airspace; Bryce Canyon, UT

    Science.gov (United States)

    2011-03-18

    ... Federal Aviation Administration 14 CFR Part 71 Modification of Class E Airspace; Bryce Canyon, UT AGENCY... airspace at Bryce Canyon, UT. Additional controlled airspace is necessary to accommodate aircraft using... a notice of proposed rulemaking to establish additional controlled airspace at Bryce Canyon, UT...

  20. 78 FR 76781 - Proposed Modification of Class B Airspace; Salt Lake City, UT

    Science.gov (United States)

    2013-12-19

    ...; Salt Lake City, UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., 2012, the FAA published a final rule modifying the Salt Lake City, UT Class B airspace area (77 FR... of aircraft operations in the Salt Lake City, UT, terminal area. Class B airspace areas are...

  1. 78 FR 33772 - Proposed Modification of Class E Airspace; Brigham City, UT

    Science.gov (United States)

    2013-06-05

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Brigham City, UT...: This action proposes to modify Class E airspace at Brigham City Airport, Brigham City, UT. The proposed... Brigham City Airport, Brigham City, UT. The existing segment would extend from the 4.3-mile radius of...

  2. 78 FR 2434 - Notice of Inventory Completion: Natural History Museum of Utah, Salt Lake City, UT

    Science.gov (United States)

    2013-01-11

    ... National Park Service Notice of Inventory Completion: Natural History Museum of Utah, Salt Lake City, UT..., Salt Lake City, UT 84108, telephone (801) 581-3876. SUPPLEMENTARY INFORMATION: Notice is here given in... Elder counties, UT. This notice is published as part of the National Park Service's...

  3. 75 FR 57288 - Notice of Inventory Completion: Utah Museum of Natural History, Salt Lake City, UT

    Science.gov (United States)

    2010-09-20

    ... National Park Service Notice of Inventory Completion: Utah Museum of Natural History, Salt Lake City, UT... of Natural History, Salt Lake City, UT. The human remains and associated funerary objects were removed from Millard and Washington Counties, UT. This notice is published as part of the National...

  4. SOCIAL RELATION NETWORKS IN UT-ONLINE COMMUNITY FORUM

    Directory of Open Access Journals (Sweden)

    Mohammad Imam FARISI

    2012-01-01

    Full Text Available So far, the existence of a virtual community forum has become a reality and social necessity in an era cybertech. It was also viewed as the electronic frontier of 21st century society that was undoubtedly for reorganizing and redefining to awareness of human being, that ways of their perceptions and explorations no longer limited by time, space, and geographic. Since the early decades of the 1990s, the existence of virtual community forum has attracted much attention and interest to the researchers, because it has significance as a social and cultural capital, and as a socio-technological solution for creating a learning community building forces. The UT-Online community forum is a virtual community forum that was built by (Universitas Terbuka UT in year 2006 to facilitate students to share and discuss various information, ideas, experiences in relation with academic or/and non-academic. This study examines and explains the contents of relation, social ties and structures of social relation networks in UT-Online Community Forum. The results of the study are important to the distance education institutions for building sense of community to DE students.

  5. UT/longitudinal variations of composition in DE data

    Science.gov (United States)

    Hedlin, A. E.

    1986-01-01

    Composition data obtained by the quadrupole mass spectrometer (NACS) carried aboard the DE-B satellite were examined for variations in the polar regions during magnetically quiet conditions. The corresponding predictions of the MSIS-83 model are often used for comparison. The MSIS-83 model is used to emphasize the variations of interest by suppressing all other variations. A persistent enhancement of N2 density and a depletion of He density are present in the vicinity of the magnetic poles with maximum density response in the morning hours (magnetic) on average. A universal time (UT) variation in average density levels is evident near both the geographic and magnetic poles. There are systematic morphology changes with UT and between summer and winter which are qualitatively consistent with the simple concept that thermospheric heating effects are shifted or spread in the downwind direction of the global circulation systems driven by EUV and magnetospheric sources. The magnitude of the UT variations is larger in the southern hemisphere and is larger in local winter than summer.

  6. Design of the ERIS calibration unit

    Science.gov (United States)

    Dolci, Mauro; Valentini, Angelo; Di Rico, Gianluca; Esposito, Simone; Ferruzzi, Debora; Riccardi, Armando; Spanò, Paolo; Antichi, Jacopo

    2016-08-01

    The Enhanced Resolution Imager and Spectrograph (ERIS) is a new-generation instrument for the Cassegrain focus of the ESO UT4/VLT, aimed at performing AO-assisted imaging and medium resolution spectroscopy in the 1-5 micron wavelength range. ERIS consists of the 1-5 micron imaging camera NIX, the 1-2.5 micron integral field spectrograph SPIFFIER (a modified version of SPIFFI, currently operating on SINFONI), the AO module and the internal Calibration Unit (ERIS CU). The purpose of this unit is to provide facilities to calibrate the scientific instruments in the 1-2.5 micron and to perform troubleshooting and periodic maintenance tests of the AO module (e.g. NGS and LGS WFS internal calibrations and functionalities, ERIS differential flexures) in the 0.5 - 1 μm range. The ERIS CU must therefore be designed in order to provide, over the full 0.5 - 2.5 μm range, the following capabilities: 1) illumination of both the telescope focal plane and the telescope pupil with a high-degree of uniformity; 2) artificial point-like and extended sources onto the telescope focal plane, with high accuracy in both positioning and FWHM; 3) wavelength calibration; 4) high stability of these characteristics. In this paper the design of the ERIS CU, and the solutions adopted to fulfill all these requirements, is described. The ERIS CU construction is foreseen to start at the end of 2016.

  7. Robotic Telescopes

    Science.gov (United States)

    Akerlof, C. W.

    2001-05-01

    Since the discovery of gamma-ray bursts, a number of groups have attempted to detect correlated optical transients from these elusive objects. Following the flight of the BATSE instrument on the Compton Gamma-Ray Observatory in 1991, a prompt burst coordinate alert service, BACODINE (now GCN) became available to ground-based telescopes. Several instruments were built to take advantage of this facility, culminating in the discovery of a bright optical flash associated with GRB990123. To date, that single observation remains unique - no other prompt flashes have been seen for a dozen or so other bursts observed with comparably short response times. Thus, GRB prompt optical luminosities may be considerably dimmer than observed for the GRB990123 event or even absent altogether. A new generation of instruments is prepared to explore these possibilties using burst coordinates provided by HETE-2, Swift, Ballerina, Agile and other satellite missions. These telescopes have response times as short as a few seconds and reach limiting magnitudes, m_v 20, guaranteeing a sensitivity sufficient to detect the afterglow many hours later. Results from these experiments should provide important new data about the dynamics and locale of GRBs.

  8. Expression and localization of a UT-B urea transporter in the human bladder.

    Science.gov (United States)

    Walpole, C; Farrell, A; McGrane, A; Stewart, G S

    2014-11-01

    Facilitative UT-B urea transporters have been shown to play an important role in the urinary concentrating mechanism. Recent studies have now suggested a link between UT-B allelic variation and human bladder cancer risk. UT-B1 protein has been previously identified in the bladder of various mammalian species, but not yet in humans. The aim of the present study was to investigate whether any UT-B protein was present in the human bladder. First, RT-PCR results confirmed that UT-B1 was strongly expressed at the RNA level in the human bladder, whereas UT-B2 was only weakly present. Initial Western blot analysis confirmed that a novel UT-B COOH-terminal antibody detected human UT-B proteins. Importantly, this antibody detected a specific 40- to 45-kDa UT-B signal in human bladder protein. Using a peptide-N-glycosidase F enzyme, this bladder UT-B signal was deglycosylated to a core 30-kDa protein, which is smaller than the predicted size for UT-B1 but similar to many proteins reported to be UT-B1. Finally, immunolocalization experiments confirmed that UT-B protein was strongly expressed throughout all urothelium layers except for the apical membrane of the outermost umbrella cells. In conclusion, these data confirm the presence of UT-B protein within the human bladder. Further studies are now required to determine the precise nature, regulation, and physiological role of this UT-B.

  9. Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

    Science.gov (United States)

    Blount, Mitsi A; Klein, Janet D; Martin, Christopher F; Tchapyjnikov, Dmitry; Sands, Jeff M

    2007-10-01

    UT-A1 is regulated by vasopressin and is localized to the apical membrane and intracellular compartment of inner medullary collecting duct (IMCD) cells. UT-A3 is also expressed in the IMCD and is regulated by forskolin in heterologous systems. The goal of the present study is to investigate mechanisms by which vasopressin regulates UT-A3 in rat IMCD. In fresh suspensions of rat IMCD, forskolin increases the phosphorylation of UT-A3, similar to UT-A1. Biotinylation studies indicate that UT-A3 is located in the plasma membrane. Forskolin treatment increases the abundance of UT-A3 in the plasma membrane similar to UT-A1. However, these two transporters do not form a complex through a protein-protein interaction, suggesting that transporter function is unique to each protein. While immunohistochemistry localized UT-A3 to the basal and lateral membranes, a majority of the staining was cytosolic. Immunohistochemistry of vasopressin-treated rat kidney sections also localized UT-A3 primarily to the cytosol with basal and lateral membrane staining but also showed some apical membrane staining in some IMCD cells. This suggests that under normal conditions, UT-A3 functions as the basolateral transporter but in a high cAMP environment, the transporter may move from the cytosol to all plasma membranes to increase urea flux in the IMCD. In summary, this study confirms that UT-A3 is located in the inner medullary tip where it is expressed in the basolateral membrane, shows that UT-A3 is a phosphoprotein in rat IMCD that can be trafficked to the plasma membrane independent of UT-A1, and suggests that vasopressin may induce UT-A3 expression in the apical plasma membrane of IMCD.

  10. Rupture utérine spontanée sur léiomyosarcome utérin

    Science.gov (United States)

    Boussouni, Khouloud; Benoulaid, Meryem; Dafiri, Rachida

    2016-01-01

    Les sarcomes utérins sont des cancers rares caractérisés par leur polymorphisme clinique et histologique. Ce sont des tumeurs malignes de mauvais pronostic. Ils se révèlent, généralement, par des symptômes non spécifiques à type de douleurs pelviennes, métrorragies. Un tableau d'abdomen aigu avec hémopneumopéritoine est une présentation rare. Nous rapportons le cas d'un léiomyosarcome utérin qui s'est manifesté par une péritonite aigue généralisée inaugurale chez une femme de 43 ans. Le diagnostic de perforation utérine sur tumeur maligne a été suspecté par l'imagerie préopératoire en urgence (échographie et TDM) et confirmé histologiquement. PMID:27642425

  11. Holographic telescope

    Science.gov (United States)

    Odhner, Jefferson E.

    2016-07-01

    Holographic optical elements (HOEs) work on the principal of diffraction and can in some cases replace conventional optical elements that work on the principal of refraction. An HOE can be thinner, lighter, can have more functionality, and can be lower cost than conventional optics. An HOE can serve as a beam splitter, spectral filter, mirror, and lens all at the same time. For a single wavelength system, an HOE can be an ideal solution but they have not been widely accepted for multispectral systems because they suffer from severe chromatic aberration. A refractive optical system also suffers from chromatic aberration but it is generally not as severe. To color correct a conventional refractive optical system, a flint glass and a crown glass are placed together such that the color dispersion of the flint and the crown cancel each other out making an achromatic lens (achromat) and the wavelengths all focus to the same point. The color dispersion of refractive lenses and holographic lenses are opposite from each other. In a diffractive optical system, long wavelengths focus closer (remember for HOEs: RBM "red bends more") than nominal focus while shorter wavelengths focus further out. In a refractive optical system, it is just the opposite. For this reason, diffractives can be incorporated into a refractive system to do the color correction and often cut down on the number of optical elements used [1.]. Color correction can also be achieved with an all-diffractive system by combining a holographic optical element with its conjugate. In this way the color dispersion of the first holographic optical element can be cancelled by the color dispersion of the second holographic optic. It is this technique that will be exploited in this paper to design a telescope made entirely of holographic optical elements. This telescope could be more portable (for field operations) the same technique could be used to make optics light enough for incorporation into a UAV.

  12. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters.

    Science.gov (United States)

    Ren, Huiwen; Wang, Yanhua; Xing, Yongning; Ran, Jianhua; Liu, Ming; Lei, Tianluo; Zhou, Hong; Li, Runtao; Sands, Jeff M; Yang, Baoxue

    2014-12-15

    Urea transporters (UT) play an important role in the urine concentration mechanism by mediating intrarenal urea recycling, suggesting that UT inhibitors could have therapeutic use as a novel class of diuretic. Recently, we found a thienoquinolin UT inhibitor, PU-14, that exhibited diuretic activity. The purpose of this study was to identify more potent UT inhibitors that strongly inhibit UT-A isoforms in the inner medullary collecting duct (IMCD). Efficient thienoquinolin UT inhibitors were identified by structure-activity relationship analysis. Urea transport inhibition activity was assayed in perfused rat terminal IMCDs. Diuretic activity of the compound was determined in rats and mice using metabolic cages. The results show that the compound PU-48 exhibited potent UT-A inhibition activity. The inhibition was 69.5% with an IC50 of 0.32 μM. PU-48 significantly inhibited urea transport in perfused rat terminal IMCDs. PU-48 caused significant diuresis in UT-B null mice, which indicates that UT-A is the target of PU-48. The diuresis caused by PU-48 did not change blood Na(+), K(+), or Cl(-) levels or nonurea solute excretion in rats and mice. No toxicity was detected in cells or animals treated with PU-48. The results indicate that thienoquinolin UT inhibitors induce a diuresis by inhibiting UT-A in the IMCD. This suggests that they may have the potential to be developed as a novel class of diuretics with fewer side effects than classical diuretics.

  13. Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder.

    Science.gov (United States)

    Li, Chun; Xue, Haogang; Lei, Yanming; Zhu, Jianqiang; Yang, Baoxue; Gai, Xiaodong

    2014-12-01

    Urea transporter B (UT-B) is a membrane protein and plays an important role in regulating urea concentration in bladder urothelial cells. It has been reported that UT-B gene mutations were related to bladder carcinogenesis, and UT-B deletion could induce DNA damage and apoptosis in bladder urothelium. However, the functions and clinical significance of UT-B in human bladder cancer remain unknown. The most common type of bladder cancer is urothelial carcinoma (UC). We hypothesized that UT-B expression was related to bladder UC progress. In this study, UT-B was detected using immunohistochemistry in 52 paraffin-embedded specimens of bladder UC and 10 normal urothelium specimens. The results showed that UT-B protein expression in UC tumor cells was significantly lower as compared with normal urothelial cells (P = 0.021). UT-B protein expression was significantly reduced with increasing histological grade (P = 0.010). UT-B protein expression in muscle-invasive stage was significantly lower than in non-muscle-invasive stage (P = 0.014). Taken together, our data suggest that the reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder UC. UT-B may be a novel diagnostic or prognostic biomarker, as well as a potential therapeutic target in UC of the bladder.

  14. UT-B Urea Transporter Localization in the Bovine Gastrointestinal Tract.

    Science.gov (United States)

    Coyle, J; McDaid, S; Walpole, C; Stewart, Gavin S

    2016-04-01

    Facilitative UT-B urea transporters play an important role in the urea nitrogen salvaging process that occurs in the gastrointestinal tract of mammals, particularly ruminants. Gastrointestinal UT-B transporters have previously been reported in various ruminant species-including cow, sheep and goat. In this present study, UT-B transporter localization was investigated in tissues throughout the bovine gastrointestinal tract. RT-PCR analysis showed that UT-B2 was the predominant UT-B mRNA transcript expressed in dorsal, ventral and cranial ruminal sacs, while alternative UT-B transcripts were present in other gastrointestinal tissues. Immunoblotting analysis detected a strong, glycosylated ~50 kDa UT-B2 protein in all three ruminal sacs. Immunolocalization studies showed that UT-B2 protein was predominantly localized to the plasma membrane of cells in the stratum basale layer of all ruminal sac papillae. In contrast, other UT-B protein staining was detected in the basolateral membranes of the surface epithelial cells lining the abomasum, colon and rectum. Overall, these findings confirm that UT-B2 cellular localization is similar in all ruminal sacs and that other UT-B proteins are located in epithelial cells lining various tissues in the bovine gastrointestinal tract.

  15. Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization.

    Science.gov (United States)

    Chen, Guangping; Howe, Ashley G; Xu, Gang; Fröhlich, Otto; Klein, Janet D; Sands, Jeff M

    2011-12-01

    The UT-A1 urea transporter is a glycoprotein with two different glycosylated forms of 97 and 117 kDa. In this study, we found the 117-kDa UT-A1 preferentially resides in lipid rafts, suggesting that the glycosylation status may interfere with UT-A1 lipid raft trafficking. This was confirmed by a site-directed mutagenesis study in MDCK cells. The nonglycosylated UT-A1 showed reduced localization in lipid rafts. By using sugar-specific binding lectins, we further found that the UT-A1 in nonlipid rafts contained a high amount of mannose, as detected by concanavalin A, while the UT-A1 in lipid rafts was the mature N-acetylglucosamine-containing form, as detected by wheat germ agglutinin. In the inner medulla (IM) of diabetic rats, the more abundant 117-kDa UT-A1 in lipid rafts was the mature glycosylation form, with high amounts of N-acetylglucosamine and sialic acid. In contrast, in the IM of normal rats, the predominant 97-kDa UT-A1 was the form enriched in mannose. Functionally, inhibition of glycosylation by tunicamycin or elimination of the glycosylation sites by mutation significantly reduced UT-A1 activity in oocytes. Taken together, our study reveals a new role of N-linked glycosylation in regulating UT-A1 activity by promoting UT-A1 trafficking into membrane lipid raft subdomains.

  16. The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.

    Science.gov (United States)

    Mistry, Abinash C; Mallick, Rickta; Fröhlich, Otto; Klein, Janet D; Rehm, Armin; Chen, Guangping; Sands, Jeff M

    2007-10-12

    The UT-A1 urea transporter mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. To transport urea, UT-A1 must be present in the plasma membrane. The purpose of this study was to screen for UT-A1-interacting proteins and to study the interactions of one of the identified potential binding partners with UT-A1. Using a yeast two-hybrid screen of a human kidney cDNA library with the UT-A1 intracellular loop (residues 409-594) as bait, we identified snapin, a ubiquitously expressed SNARE-associated protein, as a novel UT-A1 binding partner. Deletion analysis indicated that the C-terminal coiled-coil domain (H2) of snapin is required for UT-A1 interaction. Snapin binds to the intracellular loop of UT-A1 but not to the N- or C-terminal fragments. Glutathione S-transferase pulldown experiments and co-immunoprecipitation studies verified that snapin interacts with native UT-A1, SNAP23, and syntaxin-4 (t-SNARE partners), indicating that UT-A1 participates with the SNARE machinery in rat kidney inner medulla. Confocal microscopic analysis of immunofluorescent UT-A1 and snapin showed co-localization in both the cytoplasm and in the plasma membrane. When we co-injected UT-A1 with snapin cRNA in Xenopus oocytes, urea influx was significantly increased. In the absence of snapin, the influx was decreased when UT-A1 was combined with t-SNARE components syntaxin-4 and SNAP23. We conclude that UT-A1 may be linked to the SNARE machinery via snapin and that this interaction may be functionally and physiologically important for urea transport.

  17. Lo utópico de la Universidad

    Directory of Open Access Journals (Sweden)

    César Mureddu Torres

    2004-01-01

    Full Text Available El presente escrito estudia y expone lo que puede ser calificado como utópico en lo que la Universidad genera. Se distinguen al menos tres ámbitos en el mismo: el actuar de la Universidad en cuanto tal, la función de espejo, esperanza y contraste que la Universidad puede tener para con la sociedad y el que la Universidad no pueda guiarse por lo que expresamente digan sus miembros en formación. A pesar de todo ello lo que hace la Universidad no es un despropósito.

  18. No Radio Flaring Detected from Cygnus X-3 at 3 GHz by Allen Telescope Array

    Science.gov (United States)

    Williams, P. K. G.; Bower, G. C.; Tomsick, J. A.; Bodaghee, A.; Corbet, R. H. D.

    2011-01-01

    Following the announcement of a 98 GHz flare from the microquasar Cygnus X-3 (ATel #3130), we observed it with the Allen Telescope Array (Welch et al., 2009 Proc. IEEE 97 1438 for 2.5 hours beginning at 2011 January 28.848 UT (MJD 55589.848), about 4.0 hours after the 98 GHz observations concluded.

  19. X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

    DEFF Research Database (Denmark)

    Vernet, J.; Dekker, H.; D'Odorico, S.

    2011-01-01

    X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 t...

  20. X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

    NARCIS (Netherlands)

    Vernet, J.; Dekker, H.; D'Odorico, S.; Kaper, L.; Kjaergaard, P.; Hammer, F.; Randich, S.; Zerbi, F.; Groot, P.J.; Hjorth, J.; Guinouard, I.; Navarro, R.; Adolfse, T.; Albers, P.W.; Amans, J.-P.; Andersen, J.J.; Andersen, M.I.; Binetruy, P.; Bristow, P.; Castillo, R.; Chemla, F.; Christensen, L.; Conconi, P.; Conzelmann, R.; Dam, J.; De Caprio, V.; de Ugarte Postigo, A.; Delabre, B.; Di Marcantonio, P.; Downing, M.; Elswijk, E.; Finger, G.; Fischer, G.; Flores, H.; François, P.; Goldoni, P.; Guglielmi, L.; Haigron, R.; Hanenburg, H.; Hendriks, I.; Horrobin, M.; Horville, D.; Jessen, N.C.; Kerber, F.; Kern, L.; Kiekebusch, M.; Kleszcz, P.; Klougart, J.; Kragt, J.; Larsen, H.H.; Lizon, J.-L.; Lucuix, C.; Mainieri, V.; Manuputy, R.; Martayan, C.; Mason, E.; Mazzoleni, R.; Michaelsen, N.; Modigliani, A.; Moehler, S.; Møller, P.; Norup Sørensen, A.; Nørregaard, P.; Péroux, C.; Patat, F.; Pena, E.; Pragt, J.; Reinero, C.; Rigal, F.; Riva, M.; Roelfsema, R.; Royer, F.; Sacco, G.; Santin, P.; Schoenmaker, T.; Spano, P.; Sweers, E.; ter Horst, R.; Tintori, M.; Tromp, N.; van Dael, P.; van Vliet, H.; Venema, L.; Vidali, M.; Vinther, J.; Vola, P.; Winters, R.; Wistisen, D.; Wulterkens, G.; Zacchei, A.

    2011-01-01

    X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope (VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to

  1. On the Unit of Translation

    Institute of Scientific and Technical Information of China (English)

    张曼

    2013-01-01

      The unit of translation has been the focus of debate through the history of translation. Barkhudarov suggests six levels of UT, each level could serve as unit of different levels of translation. Many Chinese translators also expressed their opinions on this issue, but there is no settled answer yet. This paper tends to make a distinction between different texts:ordinary and special. Ordinary ones can adopt the UT of paragraph, while special ones should adopt special UTs according to their own characteristics.

  2. Comparative transport efficiencies of urea analogues through urea transporter UT-B.

    Science.gov (United States)

    Zhao, Dan; Sonawane, N D; Levin, Marc H; Yang, Baoxue

    2007-07-01

    Expression of urea transporter UT-B confers high urea permeability to mammalian erythrocytes. Erythrocyte membranes also permeate various urea analogues, suggesting common transport pathways for urea and structurally similar solutes. In this study, we examined UT-B-facilitated passage of urea analogues and other neutral small solutes by comparing transport properties of wildtype to UT-B-deficient mouse erythrocytes. Stopped-flow light-scattering measurements indicated high UT-B permeability to urea and chemical analogues formamide, acetamide, methylurea, methylformamide, ammonium carbamate, and acrylamide, each with P(s)>5.0 x 10(-6) cm/s at 10 degrees C. UT-B genetic knockout and phloretin treatment of wildtype erythrocytes similarly reduced urea analogue permeabilities. Strong temperature dependencies of formamide, acetamide, acrylamide and butyramide transport across UT-B-null membranes (E(a)>10 kcal/mol) suggested efficient diffusion of these amides across lipid bilayers. Urea analogues dimethylurea, acryalmide, methylurea, thiourea and methylformamide inhibited UT-B-mediated urea transport by >60% in the absence of transmembrane analogue gradients, supporting a pore-blocking mechanism of UT-B inhibition. Differential transport efficiencies of urea and its analogues through UT-B provide insight into chemical interactions between neutral solutes and the UT-B pore.

  3. Mice lacking urea transporter UT-B display depression-like behavior.

    Science.gov (United States)

    Li, Xin; Ran, Jianhua; Zhou, Hong; Lei, Tianluo; Zhou, Li; Han, Jingyan; Yang, Baoxue

    2012-02-01

    Urea transporter B is one of urea transporters that selectively transport urea driven by urea gradient across membrane and expressed abundantly in brain. To determine the physiological role of UT-B in brain, UT-B localization, urea concentration, tissue morphology of brain, and behavioral phenotypes were studied in UT-B heterozygous mice via UT-B null mice. UT-B mRNA was expressed in olfactory bulb, cortex, caudate nucleus, hippocampus and hypothalamus of UT-B heterozygous mice. UT-B null mice exhibited depression-like behavior, with urea accumulation, nitric oxide reduction, and selective neuronal nitric oxide synthase level increase in hippocampus. After acute urea loading, the urea level increased, NO production decreased in hippocampus from both types of mice. Moreover, urea level was higher, and NO concentration was lower consistently in UT-B null hippocampus than that in heterozygous hippocampus. In vitro, 25 mM urea inhibited NO production too. Furthermore, UT-B knockout induced a long-lasting notable decrease in regional cerebral blood flow and altered morphology, such as loss of neurons in CA3 region, swelling, and membranous myelin-like structure formation within myelinated and unmyelinated fibers in hippocampus. These results suggest that urea accumulation in the hippocampus induced by UT-B deletion can cause depression-like behavior, which possibly attribute to disturbance in NOS/NO system.

  4. Prospects for UT1 Measurements from VLBI Intensive Sessions

    Science.gov (United States)

    Boehm, Johannes; Nilsson, Tobias; Schuh, Harald

    2010-01-01

    Very Long Baseline Interferometry (VLBI) Intensives are one-hour single baseline sessions to provide Universal Time (UT1) in near real-time up to a delay of three days if a site is not e-transferring the observational data. Due to the importance of UT1 estimates for the prediction of Earth orientation parameters, as well as any kind of navigation on Earth or in space, there is not only the need to improve the timeliness of the results but also their accuracy. We identify the asymmetry of the tropospheric delays as the major error source, and we provide two strategies to improve the results, in particular of those Intensives which include the station Tsukuba in Japan with its large tropospheric variation. We find an improvement when (1) using ray-traced delays from a numerical weather model, and (2) when estimating tropospheric gradients within the analysis of Intensive sessions. The improvement is shown in terms of reduction of rms of length-of-day estimates w.r.t. those derived from Global Positioning System observations

  5. NESTOR Neutrino Telescope Status Report

    Science.gov (United States)

    Grieder, P. K. F.; NESTOR Collaboration; Aloupis, A.; Anassontzis, E. G.; Arvanitis, N.; Babalis, A.; Ball, A.; Bourlis, G.; Butkevich, A. V.; Chinowsky, W.; Christopoulos, P. E.; Darsaklis, A.; Dedenko, L. G.; Elistrup, D.; Fahrun, E.; Gialis, J.; Goudis, Ch.; Grammatikakis, G.; Green, C.; Karaevsky, S. K.; Katrivanos, P.; Keussen, U.; Kiskiras, J.; Knutz, Th.; Kolostelov, D.; Komlev, K.; Kontaxis, J.; Koske, P.; Learned, J. G.; Ledenev, V. V.; Leisos, A.; Limberopoulos, G.; Ludvig, J.; Makris, J.; Manousakis-Katsikakis, A.; Markopoulos, E.; Matsuno, S.; Mielke, J.; Mihos, Th.; Minkowski, P.; Mironovich, A. A.; Mitiguy, R.; Nounos, S.; Nygren, D. R.; Papageorgiou, K.; Passera, M.; Politis, C.; Preve, P.; Przybylski, G. T.; Rathlev, J.; Resvanis, L. K.; Rosen, M.; Schmidt, N.; Schmidt, Th.; Siotis, I.; Sopher, J.; Staveris, T.; Stavrakakis, G.; Stokstad, R.; Surin, N. M.; Tsagli, V.; Tsirigotis, A.; Tsirmpas, J.; Tzamarias, S.; Vasiliev, O.; Vaskine, O.; Voigt, W.; Vougioukas, A.; Voulgaris, G.; Zacharov, L. M.; Zheleznykh, I. M.; Zhukov, A.

    2003-07-01

    The first so-called flo or with 12 detector modules of the NESTOR deep sea high energy muon and neutrino telescope had been deployed successfully this March (2003) together with its electronics system. Since that data the system and the associated environmental monitoring units are operating properly and data

  6. Modulation of kidney urea transporter UT-A3 activity by alpha2,6-sialylation.

    Science.gov (United States)

    Qian, Xiaoqian; Sands, Jeff M; Song, Xiang; Chen, Guangping

    2016-07-01

    Two urea transporters, UT-A1 and UT-A3, are expressed in the kidney terminal inner medullary collecting duct (IMCD) and are important for the production of concentrated urine. UT-A1, as the largest isoform of all UT-A urea transporters, has gained much attention and been extensively studied; however, the role and the regulation of UT-A3 are less explored. In this study, we investigated UT-A3 regulation by glycosylation modification. A site-directed mutagenesis verified a single glycosylation site in UT-A3 at Asn279. Loss of the glycosylation reduced forskolin-stimulated UT-A3 cell membrane expression and urea transport activity. UT-A3 has two glycosylation forms, 45 and 65 kDa. Using sugar-specific binding lectins, the UT-A3 glycosylation profile was examined. The 45-kDa form was pulled down by lectin concanavalin A (Con A) and Galant husnivalis lectin (GNL), indicating an immature glycan with a high amount of mannose (Man), whereas the 65-kDa form is a mature glycan composed of acetylglucosamine (GlcNAc) and poly-N-acetyllactosame (poly-LacNAc) that was pulled down by wheat germ agglutinin (WGA) and tomato lectin, respectively. Interestingly, the mature form of UT-A3 glycan contains significant amounts of sialic acid. We explored the enzymes responsible for directing UT-A3 sialylation. Sialyltransferase ST6GalI, but not ST3GalIV, catabolizes UT-A3 α2,6-sialylation. Activation of protein kinase C (PKC) by PDB treatment promoted UT-A3 glycan sialylation and membrane surface expression. The PKC inhibitor chelerythrine blocks ST6GalI-induced UT-A3 sialylation. Increased sialylation by ST6GalI increased UT-A3 protein stability and urea transport activity. Collectively, our study reveals a novel mechanism of UT-A3 regulation by ST6GalI-mediated sialylation modification that may play an important role in kidney urea reabsorption and the urinary concentrating mechanism.

  7. Spectroradiometry with Space Telescopes

    CERN Document Server

    Pauluhn, Anuschka; Smith, Peter L; Colina, Luis

    2015-01-01

    Radiometry has been of fundamental importance in astronomy from the early beginnings. Initially, astronomers had their own radiometric system, based on extraterrestrial standards, namely the irradiance of stars expressed in visual magnitudes. Observing and comparing magnitudes in specific spectral bands then led to the astronomical spectrophotometry. The advent of astronomical high-resolution spectroscopy offered the possibility to interpret observations through physical models of stellar atmospheres. Such models had to be constructed based on physics-related units, and such units, rather than magnitudes, were then used for observational tests of the models. In this review, we provide an overview of how to achieve a valid laboratory calibration, and discuss ways to reliably extend this calibration to the spectroscopic telescope's performance in space. Recently, the quest for independent calibrations traceable to laboratory standards has become a well-supported aim, and has led to plans for now also launching ...

  8. The impact of celestial pole offset modelling on VLBI UT1 Intensive results

    CERN Document Server

    Malkin, Zinovy

    2011-01-01

    Very Long Baseline Interferometry (VLBI) Intensive sessions are scheduled to provide operational Universal Time (UT1) determinations with low latency. UT1 estimates obtained from these observations heavily depend on the model of the celestial pole motion used during data processing. However, even the most accurate precession-nutation model, IAU 2000/2006, is not accurate enough to realize the full potential of VLBI observations. To achieve the highest possible accuracy in UT1 estimates, a celestial pole offset (CPO), which is the difference between the actual and modelled precession-nutation angles, should be applied. Three CPO models are currently available for users. In this paper, these models have been tested and the differences between UT1 estimates obtained with those models are investigated. It has been shown that neglecting CPO modelling during VLBI UT1 Intensive processing causes systematic errors in UT1 series of up to 20 microarcseconds. It has been also found that using different CPO models causes...

  9. Rupture utérine sur utérus bicorne à 12 semaines d'aménorrhée: à propos d'un cas

    Science.gov (United States)

    Itchimouh, Sanaa; Khabtou, Karima; Mahdaoui, Sakher; Boufettal, Houssine; Samouh, Naima

    2016-01-01

    La fréquence des malformations utérines ayant un impact sur la reproduction est difficile à apprécier. Leur mise en évidence nécessite un bilan spécifique (hystérosalpingographie, hystéroscopie, cœlioscopie). La fertilité spontanée peut être altérée en fonction du type d'anomalie utérine. Toutes ces anomalies peuvent avoir des répercussions sur l’évolution de la conception à type de fausses couches précoces et tardives, de grossesse extra utérine, de menace d'accouchement prématuré, d'accouchement prématuré, de pathologies vasculaires gravidiques et de retard de croissance intra-utérin. L'utérus bicorne est la plus connue des malformations et représente environ la moitié des anomalies de l'utérus. La survenue d'une telle grossesse constitue une situation à risque pouvant entraîner une mort maternelle, mais le diagnostic précoce et un bon suivi peut mener des grossesses à terme sur des utérus malformé. Le dépistage échographique devrait permettre la détection systématique de ce genre de cas afin de prendre préventivement les mesures qui s'imposent. Nous rapportons un cas de rupture utérine sur utérus bicorne unicervical sur grossesse à 12 semaines d'aménorrhée. PMID:27642490

  10. Apollo Telescope Mount Spar Assembly

    Science.gov (United States)

    1969-01-01

    The Apollo Telescope Mount (ATM), designed and developed by the Marshall Space Flight Center, served as the primary scientific instrument unit aboard the Skylab. The ATM contained eight complex astronomical instruments designed to observe the Sun over a wide spectrum from visible light to x-rays. This image shows the ATM spar assembly. All solar telescopes, the fine Sun sensors, and some auxiliary systems are mounted on the spar, a cruciform lightweight perforated metal mounting panel that divides the 10-foot long canister lengthwise into four equal compartments. The spar assembly was nested inside a cylindrical canister that fit into the rack, a complex frame, and was protected by the solar shield.

  11. Saltone 2QCY15 TCLP toxicity and UTS results

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-08-01

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the second quarter of calendar year 2015 (2QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP)1. The 2QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  12. Saltstone 2QCY15 TCLP toxicity and UTS results

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-07-31

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the second quarter of calendar year 2015 (2QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP)¹. The 2QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  13. Saltstone 4QCY14 TCLP Toxicity and UTS Results

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-03-25

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the fourth quarter of calendar year 2014 (4QCY14). After a 47 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP) . The 4QCY14 saltstone sample results show that the saltstone is Resource Conservation Recovery Act (RCRA) nonhazardous, but is greater than the universal treatment standard for land disposal. The Saltstone Production Facility (SPF) and SDF were in a maintenance outage during the 4QCY14. Thus no processing or disposal of saltstone, as characterized by this 4QCY14 sample, occurred.

  14. Saltstone 1QCY15 TCLP Toxicity and UTS Results

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. [Savannah River Site (SRS), Aiken, SC (United States)

    2015-07-29

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the first quarter of calendar year 2015 (1QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP). The 1QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  15. Saltstone 4QCY14 TCLP Toxicity and UTS Results

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-03-25

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the fourth quarter of calendar year 2014 (4QCY14). After a 47 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP) 1 . The 4QCY14 saltstone sample results show that the saltstone is Resource Conservation Recovery Act (RCRA) nonhazardous, but is greater than the universal treatment standard for land disposal. The Saltstone Production Facility (SPF) and SDF were in a maintenance outage during the 4QCY14. Thus no processing or disposal of saltstone, as characterized by this 4QCY14 sample, occurred.

  16. Sulphate Geoengineering in the UT/LS: Some Relevant Processes

    Science.gov (United States)

    Tuck, A. F.; Donaldson, D. J.; Hitchman, M. H.; Richard, E. C.; Tervahattu, H.; Vaida, V.; Wilson, J. C.

    2008-12-01

    We consider the potential effects of meteorological dynamics, the physics and chemistry of aerosols and the photodissociation of sulphuric acid upon the posited maintenance of a 'parasol' of geoengineered sulphate aerosol in the lower stratosphere. Specific observational and experimental results include the spread of tungsten-185 from the Hardtack series of nuclear weapon tests in 1958, satellite observations of the spread of volcanic eruptions, tracer and water profiles in the tropical UT/LS, the organic coating of surfactants on aerosols, the observed distributions of aerosols and the overtone driven photodissociation of sulphuric acid in the stratosphere. A few implications for the logistics of any possible future geoengineering injection are considered briefly. The uncertainties arising from the analysis subtract significantly from the predictability of any supposed amelioration of the effects of global warming from continued increases in carbon dioxide from fossil fuel combustion.

  17. Saltstone 3QCY15 TCLP Toxicity and UTS Results

    Energy Technology Data Exchange (ETDEWEB)

    Miller, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

    2015-12-09

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the third quarter of calendar year 2015 (3QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP).1 The 3QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  18. The Timepix3 Telescope for LHCb Upgrade RD 1 measurements

    CERN Document Server

    Saunders, Daniel Martin

    2016-01-01

    The Timepix3 telescope is a high rate, data driven beam telescope created for LHCb upgrade studies, such as sensor performance for prototypes of the vertex locator (VELO) upgrade. When testing VELO prototypes the readout is identical to the telescope, and additionally, a simple way to integrate triggers from other detectors is also provided, allowing tracks to be synchronised offline with other devices under test. Examples of LHCb upgrade detectors which have been qualified with the Timepix3 telescope are the Upstream Tracker (UT), Scintillating Fibres (SciFi), Ring Imaging CHerenkov (RICH), and Time Of internally Reflected CHerenkov light (TORCH). The telescope was installed in the SPS North hall at CERN. It consists of 8 planes with 300 μ m p-on-n silicon sensors read out by Timepix3 ASICs. Tracks measured with the telescope have excellent temporal ( ∼ 1 ns) and spatial resolution ( 2 μ m). The telescope has been operated with a rate of tracks written to disk up to 5 MHz - limited only by conditions at ...

  19. In vitro siRNA-mediated knockdown of the UT receptor: implications of density on the efficacy of a range of UT ligands.

    Science.gov (United States)

    Hunt, Benjamin D; Ng, Leong L; Lambert, David G

    2012-06-01

    Urotensin-II (U-II) is the peptide agonist for the U-II receptor (UT). Putative UT antagonists, urantide and UFP-803, have been found to have variable efficacy in a range of assays. We have used siRNA-mediated RNA interference to probe the efficacy of these ligands compared to U-II. Knockdown of human UT occurs in the same cellular background with the same coupling machinery allowing relative efficacy to be probed. CHO cells stably expressing 1,110 fmol/mg protein of human UT (CHOhUT) were transfected with s194454, s194455 (UT-targeting), or a negative control siRNA using siPORT amine transfection reagent. After 48 h,silencing was assessed using quantitative PCR in a duplex assay format. Functional consequences of silencing were assessed by measuring [Ca2+]i in Fura-2 loaded cells using the NOVOstar plate reader. Silencing with s194455 was greater than that with s194454 (93.5±2.8% and 73.0±2.5%knockdown of UT mRNA respectively at 10−7 M, p00.006).Both s194455 and s194454 knocked down UT mRNA expression with equal potency (EC50 1.38 and 0.45 nM). The negative control did not affect UT mRNA expression. U-II(10−6M) increased [Ca2+]i 630±69, 402±49 and 190±14nM,urantide (10−6 M) increased [Ca2+]i 408±55, 191±40, and 131±10 nM and UFP-803 (10−6 M) increased [Ca2+]i 134±23, 83±11 and 53±3nM for negative control siRNA, s194454 and s194455, respectively.We have demonstrated silencing of UT mRNA and a reduction of absolute efficacy of three UT ligands. However, we were unable to resolve any changes in relative efficacy for urantide and UFP-803. This is likely to result from a high starting expression and retention of a receptor/coupling reserve.

  20. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats.

    Science.gov (United States)

    Cil, Onur; Esteva-Font, Cristina; Tas, Sadik Taskin; Su, Tao; Lee, Sujin; Anderson, Marc O; Ertunc, Mert; Verkman, Alan S

    2015-08-01

    Inhibitors of kidney urea transporter (UT) proteins have potential use as salt-sparing diuretics ('urearetics') with a different mechanism of action than diuretics that target salt transporters. To study UT inhibition in rats, we screened about 10,000 drugs, natural products and urea analogs for inhibition of rat UT-A1. Drug and natural product screening found nicotine, sanguinarine and an indolcarbonylchromenone with IC50 of 10-20 μM. Urea analog screening found methylacetamide and dimethylthiourea (DMTU). DMTU fully and reversibly inhibited rat UT-A1 and UT-B by a noncompetitive mechanism with IC50 of 2-3 mM. Homology modeling and docking computations suggested DMTU binding sites on rat UT-A1. Following a single intraperitoneal injection of 500 mg/kg DMTU, peak plasma concentration was 9 mM with t1/2 of about 10 h, and a urine concentration of 20-40 mM. Rats chronically treated with DMTU had a sustained, reversible reduction in urine osmolality from 1800 to 600 mOsm, a 3-fold increase in urine output, and mild hypokalemia. DMTU did not impair urinary concentrating function in rats on a low protein diet. Compared to furosemide-treated rats, the DMTU-treated rats had greater diuresis and reduced urinary salt loss. In a model of syndrome of inappropriate antidiuretic hormone secretion, DMTU treatment prevented hyponatremia and water retention produced by water-loading in dDAVP-treated rats. Thus, our results establish a rat model of UT inhibition and demonstrate the diuretic efficacy of UT inhibition.

  1. 75 FR 33560 - Proposed Establishment of Class E Airspace; Fillmore, UT

    Science.gov (United States)

    2010-06-14

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Establishment of Class E Airspace; Fillmore, UT...: This action proposes to establish Class E airspace at Fillmore, UT, to accommodate aircraft using a new... airspace extending upward from 700 feet above the surface at Fillmore Municipal Airport, Fillmore,...

  2. 75 FR 76650 - Proposed Modification of Class E Airspace; Bryce Canyon, UT

    Science.gov (United States)

    2010-12-09

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of Class E Airspace; Bryce Canyon, UT...: This action proposes to modify Class E airspace at Bryce Canyon, UT to accommodate Area Navigation... airspace extending upward from 700 feet above the surface at Bryce Canyon Airport, Bryce Canyon,...

  3. 77 FR 49712 - Amendment to Class B Airspace; Salt Lake City, UT

    Science.gov (United States)

    2012-08-17

    ..., UT AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies the Salt Lake City, UT, Class B airspace to contain aircraft conducting Instrument Flight Rules (IFR) instrument approach procedures to Salt Lake City International Airport (SLC), Salt Lake City,...

  4. Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.

    Science.gov (United States)

    Segain, Jean-Pierre; Rolli-Derkinderen, Malvyne; Gervois, Nadine; Raingeard de la Blétière, Diane; Loirand, Gervaise; Pacaud, Pierre

    2007-07-15

    Urotensin II (U-II), a vasoactive cyclic neuropeptide which activates the G protein-coupled receptor UT receptor, exerts various cardiovascular effects and may play a role in the pathophysiology of atherosclerosis. In this study, we report that the UT receptor is expressed and functional on human PBMC and rat splenocytes. PBMC surface expression of the UT receptor was mainly found in monocytes and NK cells, also in a minority of B cells, but not in T cells. Stimulation of monocytes with LPS increased UT receptor mRNA and protein expression. Cloning and functional characterization of the human UT receptor gene promoter revealed the presence of NF-kappaB-binding sites involved in the stimulation of UT receptor gene expression by LPS. Activation of the UT receptor by U-II induced chemotaxis with maximal activity at 10 and 100 nM. This U-II effect was restricted to monocytes. Analysis of the signaling pathway involved indicated that U-II-mediated chemotaxis was related to RhoA and Rho kinase activation and actin cytoskeleton reorganization. The present results thus identify U-II as a chemoattractant for UT receptor-expressing monocytes and indicate a pivotal role of the RhoA-Rho kinase signaling cascade in the chemotaxis induced by U-II.

  5. Vasopressin regulation of the renal UT-A3 urea transporter.

    Science.gov (United States)

    Stewart, G S; Thistlethwaite, A; Lees, H; Cooper, G J; Smith, Craig

    2009-03-01

    Facilitative urea transporters in the mammalian kidney play a vital role in the urinary concentrating mechanism. The urea transporters located in the renal inner medullary collecting duct, namely UT-A1 and UT-A3, are acutely regulated by the antidiuretic hormone vasopressin. In this study, we investigated the vasopressin regulation of the basolateral urea transporter UT-A3 using an MDCK-mUT-A3 cell line. Within 10 min, vasopressin stimulates urea flux through UT-A3 transporters already present at the plasma membrane, via a PKA-dependent process. Within 1 h, vasopressin significantly increases UT-A3 localization at the basolateral membrane, causing a further increase in urea transport. While the basic trafficking of UT-A3 to basolateral membranes involves both protein kinase C and calmodulin, its regulation by vasopressin specifically occurs through a casein kinase II-dependent pathway. In conclusion, this study details the effects of vasopressin on UT-A3 urea transporter function and hence its role in regulating urea permeability within the renal inner medullary collecting duct.

  6. 77 FR 30883 - Amendment of Area Navigation (RNAV) Route Q-130; UT

    Science.gov (United States)

    2012-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 ; Amendment of Area Navigation (RNAV) Route Q-130; UT... (Lat. 38 24'00'' N., long. 114 20'00'' W.) ROCCY, UT WP (Lat. 37 49'42'' N., long. 111 59'60''...

  7. 78 FR 66355 - Pleasant Grove City, UT; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-11-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Pleasant Grove City, UT; Notice of Preliminary Determination of a Qualifying.... Applicant Contact: Dean Lundell, Pleasant Grove City, Utah, 70 South 100 East, Pleasant Grove, UT...

  8. High Speed Telescopic Imaging of Sprites

    Science.gov (United States)

    McHarg, M. G.; Stenbaek-Nielsen, H. C.; Kanmae, T.; Haaland, R. K.

    2010-12-01

    A total of 21 sprite events were recorded at Langmuir Laboratory, New Mexico, during the nights of 14 and 15 July 2010 with a 500 mm focal length Takahashi Sky 90 telescope. The camera used was a Phantom 7.3 with a VideoScope image intensifier. The images were 512x256 pixels for a field of view of 1.3x0.6 degrees. The data were recorded at 16,000 frames per second (62 μs between images) and an integration time of 20 μs per image. Co-aligned with the telescope was a second similar high-speed camera, but with an 85 mm Nikon lens; this camera recorded at 10,000 frames per second with 100 μs exposure. The image format was also 512x256 pixels for a field of view of 7.3x3.7 degrees. The 21 events recorded include all basic sprite elements: Elve, sprite halos, C-sprites, carrot sprites, and large jellyfish sprites. We compare and contrast the spatial details seen in the different types of sprites, including streamer head size and the number of streamers subsequent to streamer head splitting. Telescopic high speed image of streamer tip splitting in sprites recorded at 07:06:09 UT on 15 July 2010.

  9. New Advances in Urea Transporter UT-A1 Membrane Trafficking

    Directory of Open Access Journals (Sweden)

    Guangping Chen

    2013-05-01

    Full Text Available The vasopressin-regulated urea transporter UT-A1, expressed in kidney inner medullary collecting duct (IMCD epithelial cells, plays a critical role in the urinary concentrating mechanisms. As a membrane protein, the function of UT-A1 transport activity relies on its presence in the plasma membrane. Therefore, UT-A1 successfully trafficking to the apical membrane of the polarized epithelial cells is crucial for the regulation of urea transport. This review summarizes the research progress of UT-A1 regulation over the past few years, specifically on the regulation of UT-A1 membrane trafficking by lipid rafts, N-linked glycosylation and a group of accessory proteins.

  10. New advances in urea transporter UT-A1 membrane trafficking.

    Science.gov (United States)

    Chen, Guangping

    2013-05-21

    The vasopressin-regulated urea transporter UT-A1, expressed in kidney inner medullary collecting duct (IMCD) epithelial cells, plays a critical role in the urinary concentrating mechanisms. As a membrane protein, the function of UT-A1 transport activity relies on its presence in the plasma membrane. Therefore, UT-A1 successfully trafficking to the apical membrane of the polarized epithelial cells is crucial for the regulation of urea transport. This review summarizes the research progress of UT-A1 regulation over the past few years, specifically on the regulation of UT-A1 membrane trafficking by lipid rafts, N-linked glycosylation and a group of accessory proteins.

  11. Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.

    Science.gov (United States)

    Yao, Chenjuan; Anderson, Marc O; Zhang, Jicheng; Yang, Baoxue; Phuan, Puay-Wah; Verkman, A S

    2012-07-01

    Urea transport (UT) proteins facilitate the concentration of urine by the kidney, suggesting that inhibition of these proteins could have therapeutic use as a diuretic strategy. We screened 100,000 compounds for UT-B inhibition using an optical assay based on the hypotonic lysis of acetamide-loaded mouse erythrocytes. We identified a class of triazolothienopyrimidine UT-B inhibitors; the most potent compound, UTB(inh)-14, fully and reversibly inhibited urea transport with IC(50) values of 10 nM and 25 nM for human and mouse UT-B, respectively. UTB(inh)-14 competed with urea binding at an intracellular site on the UT-B protein. UTB(inh)-14 exhibited low toxicity and high selectivity for UT-B over UT-A isoforms. After intraperitoneal administration of UTB(inh)-14 in mice to achieve predicted therapeutic concentrations in the kidney, urine osmolality after administration of 1-deamino-8-D-arginine-vasopressin was approximately 700 mosm/kg H(2)O lower in UTB(inh)-14-treated mice than vehicle-treated mice. UTB(inh)-14 also increased urine output and reduced urine osmolality in mice given free access to water. UTB(inh)-14 did not reduce urine osmolality in UT-B knockout mice. In summary, these data provide proof of concept for the potential utility of UT inhibitors to reduce urinary concentration in high-vasopressin, fluid-retaining conditions. The diuretic mechanism of UT inhibitors may complement the action of conventional diuretics, which target sodium transport.

  12. Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity.

    Science.gov (United States)

    Su, Hua; Carter, Conner B; Fröhlich, Otto; Cummings, Richard D; Chen, Guangping

    2012-07-15

    Urea transporters UT-A1 and UT-A3 are both expressed in the kidney inner medulla. However, the function of UT-A3 remains unclear. Here, we found that UT-A3, which comprises only the NH(2)-terminal half of UT-A1, has a higher urea transport activity than UT-A1 in the oocyte and that this difference was associated with differences in N-glycosylation. Heterologously expressed UT-A3 is fully glycosylated with two glycoforms of 65 and 45 kDa. By contrast, UT-A1 expressed in HEK293 cells and oocytes exhibits only a 97-kDa glycosylation form. We further found that N-glycans of UT-A3 contain a large amount of poly-N-acetyllactosamine. This highly glycosylated UT-A3 is more stable and is enriched in lipid raft domains on the cell membrane. Kifunensine, an inhibitor of α-mannosidase that inhibits N-glycan processing beyond high-mannose-type N-glycans, significantly reduced UT-A3 urea transport activity. We then examined the native UT-A1 and UT-A3 glycosylation states from kidney inner medulla and found the ratio of 65 to 45 kDa in UT-A3 is higher than that of 117 to 97 kDa in UT-A1. The highly stable expression of highly glycosylated UT-A3 on the cell membrane in kidney inner medulla suggests that UT-A3 may have an important function in urea reabsorption.

  13. The SOFIA Telescope

    CERN Document Server

    Krabbe, A

    2000-01-01

    The SOFIA telescope as the heart of the observatory is a major technological challenge. I present an overview on the astro-nomical and scientific requirements for such a big airborne observatory and demonstrate the impact of these requirements on the layout of SOFIA, in particular on the telescope design as it is now. Selected components of the telescope will be de-scribed in their context and functionality. The current status of the telescope is presented.

  14. High-Flying Telescope

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    Scientists at the Space Telescope Science Institute,which operates the Hubble Space Telescope,have proposed a new telescope that would have twice the resolution of Hubble at about one-tenth the cost. It would hover seven miles above Earth,dangling below a football-field-size helium balloon

  15. Auto Adjusting Astronomical Telescope

    Directory of Open Access Journals (Sweden)

    Rohit R. Ghalsasi

    2014-04-01

    Full Text Available Astronomical telescope is powerful and basic tool for star or celestial observation. Here we proposed integrated system using Raspberry Pi for auto adjusting astronomical telescope. This integrated circuit helps to control stellar monitoring, stellar targeting, and tracking functions of telescope. Astro compass gives the direction of the celestial objects.

  16. ATST telescope mount: telescope of machine tool

    Science.gov (United States)

    Jeffers, Paul; Stolz, Günter; Bonomi, Giovanni; Dreyer, Oliver; Kärcher, Hans

    2012-09-01

    The Advanced Technology Solar Telescope (ATST) will be the largest solar telescope in the world, and will be able to provide the sharpest views ever taken of the solar surface. The telescope has a 4m aperture primary mirror, however due to the off axis nature of the optical layout, the telescope mount has proportions similar to an 8 meter class telescope. The technology normally used in this class of telescope is well understood in the telescope community and has been successfully implemented in numerous projects. The world of large machine tools has developed in a separate realm with similar levels of performance requirement but different boundary conditions. In addition the competitive nature of private industry has encouraged development and usage of more cost effective solutions both in initial capital cost and thru-life operating cost. Telescope mounts move relatively slowly with requirements for high stability under external environmental influences such as wind buffeting. Large machine tools operate under high speed requirements coupled with high application of force through the machine but with little or no external environmental influences. The benefits of these parallel development paths and the ATST system requirements are being combined in the ATST Telescope Mount Assembly (TMA). The process of balancing the system requirements with new technologies is based on the experience of the ATST project team, Ingersoll Machine Tools who are the main contractor for the TMA and MT Mechatronics who are their design subcontractors. This paper highlights a number of these proven technologies from the commercially driven machine tool world that are being introduced to the TMA design. Also the challenges of integrating and ensuring that the differences in application requirements are accounted for in the design are discussed.

  17. The Cherenkov Telescope Array Large Size Telescope

    CERN Document Server

    Ambrosi, G; Baba, H; Bamba, A; Barceló, M; de Almeida, U Barres; Barrio, J A; Bigas, O Blanch; Boix, J; Brunetti, L; Carmona, E; Chabanne, E; Chikawa, M; Colin, P; Conteras, J L; Cortina, J; Dazzi, F; Deangelis, A; Deleglise, G; Delgado, C; Díaz, C; Dubois, F; Fiasson, A; Fink, D; Fouque, N; Freixas, L; Fruck, C; Gadola, A; García, R; Gascon, D; Geffroy, N; Giglietto, N; Giordano, F; Grañena, F; Gunji, S; Hagiwara, R; Hamer, N; Hanabata, Y; Hassan, T; Hatanaka, K; Haubold, T; Hayashida, M; Hermel, R; Herranz, D; Hirotani, K; Inoue, S; Inoue, Y; Ioka, K; Jablonski, C; Kagaya, M; Katagiri, H; Kishimoto, T; Kodani, K; Kohri, K; Konno, Y; Koyama, S; Kubo, H; Kushida, J; Lamanna, G; Flour, T Le; López-Moya, M; López, R; Lorenz, E; Majumdar, P; Manalaysay, A; Mariotti, M; Martínez, G; Martínez, M; Mazin, D; Miranda, J M; Mirzoyan, R; Monteiro, I; Moralejo, A; Murase, K; Nagataki, S; Nakajima, D; Nakamori, T; Nishijima, K; Noda, K; Nozato, A; Ohira, Y; Ohishi, M; Ohoka, H; Okumura, A; Orito, R; Panazol, J L; Paneque, D; Paoletti, R; Paredes, J M; Pauletta, G; Podkladkin, S; Prast, J; Rando, R; Reimann, O; Ribó, M; Rosier-Lees, S; Saito, K; Saito, T; Saito, Y; Sakaki, N; Sakonaka, R; Sanuy, A; Sasaki, H; Sawada, M; Scalzotto, V; Schultz, S; Schweizer, T; Shibata, T; Shu, S; Sieiro, J; Stamatescu, V; Steiner, S; Straumann, U; Sugawara, R; Tajima, H; Takami, H; Tanaka, S; Tanaka, M; Tejedor, L A; Terada, Y; Teshima, M; Totani, T; Ueno, H; Umehara, K; Vollhardt, A; Wagner, R; Wetteskind, H; Yamamoto, T; Yamazaki, R; Yoshida, A; Yoshida, T; Yoshikoshi, T

    2013-01-01

    The two arrays of the Very High Energy gamma-ray observatory Cherenkov Telescope Array (CTA) will include four Large Size Telescopes (LSTs) each with a 23 m diameter dish and 28 m focal distance. These telescopes will enable CTA to achieve a low-energy threshold of 20 GeV, which is critical for important studies in astrophysics, astroparticle physics and cosmology. This work presents the key specifications and performance of the current LST design in the light of the CTA scientific objectives.

  18. Differential protein expression in heart in UT-B null mice with cardiac conduction defects.

    Science.gov (United States)

    Yu, Hao; Meng, Yan; Wang, Li-Shun; Jin, Xian; Gao, Li-Fang; Zhou, Lei; Ji, Kun; Li, Yang; Zhao, Li-Juan; Chen, Guo-Qiang; Zhao, Xue-Jian; Yang, Baoxue

    2009-02-01

    Cardiac conduction defects were found in transgenic mice deficient in urea transporter UT-B. To investigate the molecular mechanisms of the conduction defects caused by UT-B deletion, we studied the protein expression profiles of heart tissue (comprising most conduction system) in wild-type versus UT-B null mice at different ages. By two-dimensional electrophoresis-based comparative analysis, we found that more than dozen proteins were modulated (>two-fold) in the myocardium of UT-B null mice. Out of these modulated proteins, troponin T (TNNT2) presented significant changes in UT-B null mice at early stage prior to the development of P-R interval elongation, while the change of atrial natriuretic peptide (ANP) occurred only at late stage in UT-B null mice that had the AV block. These data indicate that UT-B deletion caused the dynamic expression regulation of TNNT2 and ANP, and these proteins may provide new clues to investigate the molecular events involved in cardiac conduction.

  19. Short communication: urea transporter protein UT-B in the bovine parotid gland.

    Science.gov (United States)

    Dix, L; Ward, D T; Stewart, G S

    2013-03-01

    Ruminant nutrition relies upon the symbiotic relationship that exists with microbial populations in the rumen. Urea transported across the ruminal epithelia and secreted by the salivary glands is a key source of nitrogen for microbial growth in the rumen. As ruminal urea transport can be mediated by specific UT-B urea transporters, this study investigated whether UT-B urea transporters were also present in the bovine salivary gland. Western blotting experiments detected only small amounts of UT-B protein in whole-cell lysate from the bovine parotid gland. In contrast, strong 32 to 34 and 40 kDa UT-B proteins were detected in parotid plasma membrane-enriched protein, showing the importance of using enriched samples. These signals were also detected in rumen and correspond to bovine UT-B1 and UT-B2 urea transporters, respectively. Further immunolocalization studies identified that these proteins were located in the ductal system of the parotid gland. This study, therefore, confirmed the presence of UT-B urea transporter protein in the bovine parotid salivary gland.

  20. Differential protein abundance and function of UT-B urea transporters in human colon.

    Science.gov (United States)

    Collins, D; Winter, D C; Hogan, A M; Schirmer, L; Baird, A W; Stewart, G S

    2010-03-01

    Facilitative UT-B urea transporters enable the passage of urea across cell membranes. Gastrointestinal urea transporters are thought to play a significant role in the urea nitrogen salvaging process that occurs between mammalian hosts and their gut bacteria. This study investigated the expression of UT-B urea transporters in different segments of human colon. Immunoblot analysis showed that human colon expressed a 35-kDa glycosylated UT-B protein in the colonic mucosa. The 35-kDa UT-B transporter was predominantly located in plasma membrane-enriched samples (P UT-B transporters were located throughout colonocytes situated in the upper portion of the colonic crypts. Bidirectional trans-epithelial urea transport was significantly greater in the ascending colon than the descending colon (P UT-B protein in different sections of the human colon, strongly correlating to regions that contain the largest populations of intestinal bacteria. This study suggests an important role for UT-B urea transporters in maintaining the symbiotic relationship between humans and their gut bacteria.

  1. The Africa Millimetre Telescope

    Science.gov (United States)

    Backes, M.; Müller, C.; Conway, J. E.; Deane, R.; Evans, R.; Falcke, H.; Fraga-Encinas, R.; Goddi, C.; Klein Wolt, M.; Krichbaum, T. P.; MacLeod, G.; Ribeiro, V. A. R. M.; Roelofs, F.; Shen, Z. Q.; van Langevelde, H. J.

    It is believed that supermassive black holes are found in the centres of galaxies, including the Milky Way. Still, only indirect evidence has been gathered for the existence of these enigmatic objects that are predicted by the general theory of relativity. With the Event Horizon Telescope, a Very Long Baseline Interferometry network of millimetre-wave (radio) telescopes, it will be possible to directly image the 'shadow' of the event horizon of the black hole at the centre of the Milky Way, Sgr A*. Although the Event Horizon Telescope utilises an extensive network of telescopes, there is a huge gap in the coverage of the u-v-plane for these observations across Africa. We discuss the benefits of adding the Africa Millimetre Telescope to the Event Horizon Telescope and present Mt. Gamsberg in Namibia as the best site for this new and first mm-wave telescope in Africa.

  2. 78 FR 36743 - Adoption of Final Environmental Assessment (UT-040-09-03) Prepared for the Upper Kanab Creek...

    Science.gov (United States)

    2013-06-19

    ... Natural Resources Conservation Service Adoption of Final Environmental Assessment (UT-040-09-03) Prepared... Lake City, Utah 84138; email at gary.mcrae@ut.usda.gov . SUPPLEMENTARY INFORMATION: NRCS announces its intent to adopt the Kanab Creek Watershed Vegetation Management Project EA (UT-040-09-03) prepared by...

  3. 75 FR 73983 - Proposed Modification of the Salt Lake City, UT, Class B Airspace Area; Public Meetings

    Science.gov (United States)

    2010-11-30

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Modification of the Salt Lake City, UT, Class B... Lake City, UT. The purpose of these meetings is to provide interested parties an opportunity to present... held in the Ogden Conference Room, Ogden Hinckley Airport Terminal, 3909 Airport Road, Ogden, UT,...

  4. Single crystal growth and physical properties of UT2Al20 (T=Transition Metal)

    OpenAIRE

    Matsumoto, Y.; Matsuda, TD; Tateiwa, N.; Yamamoto, E; Haga, Y; Fisk, Z.

    2013-01-01

    We have studied the single crystal growth and the physical properties of the UT2Al20 system. We have successfully grown UT2Al20 (T = Cr, Ti, W and Mo) using Al self flux and have characterized the crystals using electron probe microanalyzer (EPAM) and X-ray diffractometer. We have also measured their magnetic and electric properties. The ground states of UT2Al20 (T = Cr, Mo and W) are Pauli paramagnetic as is likely also in UTi2Al20. The effective masses of UCr2Al20 and UTi2Al20 are only weak...

  5. La escritura utópica de Mario Vargas Llosa

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Huamán

    2011-07-01

    Full Text Available Uno de los efectos más recurrentes de la escritura literaria es el asombro que se produce en el lector frente a la revelación de la dimensión estética.A partir de esa experiencia, el usuario intenta descifrar o comprender la peculiar naturaleza de la creación verbal. Entonces, en el afán por entender el secreto de la palabra poética, la primera alternativa consiste en indagar en el autor o escritor al respecto, porque se supone que quién ha concretado una obra que genera tal reacción, debe de saber en qué consiste su arte, su destreza, su particular habilidad creativa. En este sentido, la intención de este artículo es realizar una rápida revisión del “arte poética”del autor de La casa verde, con el objeto de clarificar la continuidad de sus convicciones básicas y observar cómo la aparente adscripción de su postura a una opción esteticista, que algunos han considerado homóloga a su postura ideológica a favor del liberalismo, ha sido modificada, de conformidad con sus últimas reflexiones. Ello acerca su obra a la del otrogran narrador peruano del siglo XX: José María Arguedas.Palabras claves: Mario Vargas Llosa, arte poética, escritura utópica, narrativa peruana.

  6. Liverpool Telescope and Liverpool Telescope 2

    Science.gov (United States)

    Copperwheat, C. M.; Steele, I. A.; Barnsley, R. M.; Bates, S. D.; Clay, N. R.; Jermak, H.; Marchant, J. M.; Mottram, C. J.; Piascik, A.; Smith, R. J.

    2016-12-01

    The Liverpool Telescope is a fully robotic optical/near-infrared telescope with a 2-metre clear aperture, located at the Observatorio del Roque de los Muchachos on the Canary Island of La Palma. The telescope is owned and operated by Liverpool John Moores University, with financial support from the UK's Science and Technology Facilities Council. The telescope began routine science operations in 2004 and is a common-user facility with time available through a variety of committees via an open, peer reviewed process. Seven simultaneously mounted instruments support a broad science programme, with a focus on transient follow-up and other time domain topics well suited to the characteristics of robotic observing. Development has also begun on a successor facility, with the working title `Liverpool Telescope 2', to capitalise on the new era of time domain astronomy which will be brought about by the next generation of survey facilities such as LSST. The fully robotic Liverpool Telescope 2 will have a 4-metre aperture and an improved response time. In this paper we provide an overview of the current status of both facilities.

  7. Rupture utérine sur utérus bicorne à 12 semaines d'aménorrhée: à propos d'un cas

    OpenAIRE

    Itchimouh, Sanaa; Khabtou, Karima; Mahdaoui, Sakher; Boufettal, Houssine; Samouh, Naima

    2016-01-01

    La fréquence des malformations utérines ayant un impact sur la reproduction est difficile à apprécier. Leur mise en évidence nécessite un bilan spécifique (hystérosalpingographie, hystéroscopie, cœlioscopie). La fertilité spontanée peut être altérée en fonction du type d'anomalie utérine. Toutes ces anomalies peuvent avoir des répercussions sur l’évolution de la conception à type de fausses couches précoces et tardives, de grossesse extra utérine, de menace d'accouchement prématuré, d'accouch...

  8. Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.

    Science.gov (United States)

    Mistry, Abinash C; Mallick, Rickta; Klein, Janet D; Sands, Jeff M; Fröhlich, Otto

    2010-06-01

    Of the three major protein variants produced by the UT-A gene (UT-A1, UT-A2, and UT-A3) UT-A1 is the largest. It contains UT-A3 as its NH(2)-terminal half and UT-A2 as its COOH-terminal half. When being part of UT-A1, UT-A3 and UT-A2 are joined by a segment, Lp, whose central part, Lc, is not part of UT-A3 or UT-A2 but is present only in UT-A1. Lc contains the phosphorylation sites S486 and S499 that are involved in protein kinase A-dependent activation, as well as the binding site for snapin, a protein involved in soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE)-mediated vesicle trafficking and fusion to the plasma membrane. We attached Lc to UT-A2 and UT-A3 to test how these phosphorylation sites influenced their urea transport activity. Adding Lc to UT-A2 conferred stimulation by cAMP to the cAMP-unresponsive UT-A2, and adding Lc to UT-A3 did not further enhance its already existing cAMP response. These findings suggest that the responsiveness to vasopressin that is observed with UT-A1 can be introduced into the unresponsive UT-A2 variant through the Lc segment that is unique to UT-A1. In UT-A3, however, the Lc segment plays no significant role in its activation by cAMP. In addition, the Lc segment also gave UT-A2 the ability to bind snapin and, in Xenopus oocytes, to be stimulated in its urea transport activity by snapin and syntaxins 3 and 4, in the same way as UT-A1.

  9. Vasopressin increases expression of UT-A1, UT-A3, and ER chaperone GRP78 in the renal medulla of mice with a urinary concentrating defect.

    Science.gov (United States)

    Cai, Qi; Nelson, Sarah K; McReynolds, Matthew R; Diamond-Stanic, Maggie Keck; Elliott, David; Brooks, Heddwen L

    2010-10-01

    Activation of V2 receptors (V2R) during antidiuresis increases the permeability of the inner medullary collecting duct to urea and water. Extracellular osmolality is elevated as the concentrating capacity of the kidney increases. Osmolality is known to contribute to the regulation of collecting duct water (aquaporin-2; AQP2) and urea transporter (UT-A1, UT-A3) regulation. AQP1KO mice are a concentrating mechanism knockout, a defect attributed to the loss of high interstitial osmolality. A V2R-specific agonist, deamino-8-D-arginine vasopressin (dDAVP), was infused into wild-type and AQP1KO mice for 7 days. UT-A1 mRNA and protein abundance were significantly increased in the medullas of wild-type and AQP1KO mice following dDAVP infusion. The mRNA and protein abundance of UT-A3, the basolateral urea transporter, was significantly increased by dDAVP in both wild-type and AQP1KO mice. Semiquantitative immunoblots revealed that dDAVP infusion induced a significant increase in the medullary expression of the endoplasmic reticulum (ER) chaperone GRP78. Immunofluorescence studies demonstrated that GRP78 expression colocalized with AQP2 in principal cells of the papillary tip of the renal medulla. Using immunohistochemistry and immunogold electron microscopy, we demonstrate that vasopressin induced a marked apical targeting of GRP78 in medullary principal cells. Urea-sensitive genes, GADD153 and ATF4 (components of the ER stress pathway), were significantly increased in AQP1KO mice by dDAVP infusion. These findings strongly support an important role of vasopressin in the activation of an ER stress response in renal collecting duct cells, in addition to its role in activating an increase in UT-A1 and UT-A3 abundance.

  10. Downregulation of UT-A1/UT-A3 is associated with urinary concentrating defect in glucocorticoid-excess state.

    Science.gov (United States)

    Li, Chunling; Wang, Weidong; Summer, Sandra N; Falk, Sandor; Schrier, Robert W

    2008-10-01

    Excessive glucocorticoid hormone, as occurs with Cushing syndrome, is known to be associated with altered body water homeostasis, but the molecular mechanisms are unknown. In this study, rats treated with daily dexamethasone (Dex) for 14 d provided a model of Cushing syndrome. Compared with control rats, Dex-treated rats demonstrated increased mean arterial pressure, urine flow rate, and urinary excretion of both sodium and urea. Dex-treated rats had increased abundance of aquaporin 1 (AQP1), AQP3, and Na-K-2Cl co-transporter proteins and a marked reduction of the urea transporters UT-A1 and UT-A3. In response to an acute water load, Dex-treated rats increased water excretion more than control rats, but both groups exhibited similar AQP2 expression. In response to fluid deprivation, Dex-treated rats demonstrated an impaired urinary concentrating capacity: Urine flow rate was higher and urine osmolality was lower than control rats despite an increase in AQP1, AQP3, and Na-K-2Cl co-transporter expression. AQP2 expression was similar between the two groups, but UT-A1 and UT-A3 were decreased and urinary urea excretion was increased in Dex-treated rats. Because Dex-treated rats ingested less food and water compared with controls, paired food and water studies were performed; these substantiated the previous results. In summary, the alterations in body water observed with glucocorticoid excess may be a result, in part, of impaired urinary concentrating capacity; downregulation of UT-A1 and UT-A3 and increased urea excretion may contribute to this impairment.

  11. ESO takes the public on an astronomical journey "Around the World in 80 Telescopes"

    Science.gov (United States)

    2009-03-01

    A live 24-hour free public video webcast, "Around the World in 80 Telescopes", will take place from 3 April 09:00 UT/GMT to 4 April 09:00 UT/GMT, chasing day and night around the globe to let viewers "visit" some of the most advanced astronomical telescopes on and off the planet. The webcast, organised by ESO for the International Year of Astronomy 2009 (IYA2009), is the first time that so many large observatories have been linked together for a public event. ESO PR Photo 13a/09 Map of Participating Observatories ESO PR Photo 13b/09 100 Hours of Astronomy logo Viewers will see new images of the cosmos, find out what observatories in their home countries or on the other side of the planet are discovering, send in questions and messages, and discover what astronomers are doing right now. Participating telescopes include those at observatories in Chile such as ESO's Very Large Telescope and La Silla, the Hawaii-based telescopes Gemini North and Keck, the Anglo-Australian Telescope, telescopes in the Canary Islands, the Southern African Large Telescope, space-based telescopes such as the NASA/ESA Hubble Space Telescope, ESA XMM-Newton and Integral, and many more. "Around the World in 80 Telescopes" will take viewers to every continent, including Antarctica! The webcast production will be hosted at ESO's headquarters near Munich, Germany, with live internet streaming by Ustream.tv. Anyone with a web browser supporting Adobe Flash will be able to follow the show, free of charge, from the website www.100hoursofastronomy.org and be a part of the project by sending messages and questions. The video player can be freely embedded on other websites. TV stations, web portals and science centres can also use the high quality feed. Representatives of the media who wish to report from the "front-line" and interview the team should get in touch. "Around the World in 80 Telescopes" is a major component of the 100 Hours of Astronomy (100HA), a Cornerstone project of the International

  12. 75 FR 47488 - FM Table of Allotments, Boulder Town, Levan, Mount Pleasant, and Richfield, UT

    Science.gov (United States)

    2010-08-06

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 FM Table of Allotments, Boulder Town, Levan, Mount Pleasant, and Richfield, UT AGENCY: Federal Communications Commission. ACTION: Final rule; petition for partial...

  13. 75 FR 41898 - Slash Support, Inc. Gamehouse Products Support Workers South Jordan, UT; Notice of Revised...

    Science.gov (United States)

    2010-07-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Slash Support, Inc. Gamehouse Products Support Workers South Jordan, UT; Notice of Revised Determination on Reconsideration By application dated March 25, 2010,...

  14. The Solar Telescope GREGOR

    Science.gov (United States)

    Volkmer, R.

    2008-09-01

    During the last years the new 1.5m solar telescope GREGOR was assembled at Izania on Tenerife, Spain. The telescope is designed for high-precision measurements of the magnetic field in the solar photosphere and chromosphere with a resolution of 70km on the Sun. The telescope concept offers also high resolution stellar spectroscopy. The telescope is build by a consortium of the Kiepenheuer-Institut für Sonnenphysik, the Astrophysikalische Institut Potsdam, the Institut für Astrophysik Göttingen, Max-Plank-Institut für Sonnensystemforschung and additional international Partners. The telescope is a complete open structure with active cooled main mirror. High performance post-focus instruments in the visible and near IR wavelength acquire high resolution spectra with 2 dimensional spatial resolution and polarimetric information. The commissioning of the telescope will start in 2008 to allow first science observations at the end of 2009.

  15. JWST Pathfinder Telescope Integration

    Science.gov (United States)

    Matthews, Gary W.; Kennard, Scott H.; Broccolo, Ronald T.; Ellis, James M.; Daly, Elizabeth A.; Hahn, Walter G.; Amon, John N.; Mt. Pleasant, Stephen M.; Texter, Scott; Atkinson, Charles B.; McKay, Andrew; Levi, Joshua; Keski-Kuha, Ritva; Feinberg, Lee

    2015-01-01

    The James Webb Space Telescope (JWST) is a 6.5m, segmented, IR telescope that will explore the first light of the universe after the big bang. In 2014, a major risk reduction effort related to the Alignment, Integration, and Test (AI&T) of the segmented telescope was completed. The Pathfinder telescope includes two Primary Mirror Segment Assemblies (PMSA's) and the Secondary Mirror Assembly (SMA) onto a flight-like composite telescope backplane. This pathfinder allowed the JWST team to assess the alignment process and to better understand the various error sources that need to be accommodated in the flight build. The successful completion of the Pathfinder Telescope provides a final integration roadmap for the flight operations that will start in August 2015.

  16. Welfare Effects of Tax and Price Changes and the CES-UT Utility Function

    DEFF Research Database (Denmark)

    Munk, Knud Jørgen

    this insight cannot be articulated. This paper proposes as an alternative a parameterised utility function with explicit representation of the use of time, the CES-UT, which allows a flexible representation of the relationship between consumption and leisure. It also demonstrates how standard compensated price...... elasticities can be derived from the parameters of the CES-UT and how it may be used for applied tax reform analysis...

  17. The great Melbourne telescope

    CERN Document Server

    Gillespie, Richard

    2011-01-01

    Erected at Melbourne Observatory in 1869, the telescope was the second largest in the world, designed to explore the nature of the nebulae in the southern skies. Richard Gillespie, head of the History and Technology department at the Melbourne museum has written an entertaining account of the telescope's extraordinary history and tells the story through an amazing cast of characters whose lives intersected with the telescope.

  18. Pointing a solar telescope

    Science.gov (United States)

    Wallace, Patrick

    2016-07-01

    As far as pointing is concerned, a solar telescope is merely an ordinary astronomical telescope but with enhancements for observing solar and coronal features. The paper discusses the additional coordinate systems that need to be supported, shows how to generate the required solar ephemerides (both orbital and physical), and sets out a suitable application programming interface for the telescope control system to use when making solar observations.

  19. The N-terminal 81-aa fragment is critical for UT-A1 urea transporter bioactivity.

    Science.gov (United States)

    Huang, Haidong; Yang, Yuan; Eaton, Douglas C; Sands, Jeff M; Chen, Guangping

    2010-01-01

    The serine protease, furin, is involved in the activation of a number of proteins most notably epithelial sodium channels (ENaC). The urea transporter UT-A1, located in the kidney inner medullary collecting duct (IMCD), is important for urine concentrating ability. UT-A1's amino acid sequence has a consensus furin cleavage site (RSKR) in the N-terminal region. Despite the putative cleavage site, we find that UT-A1, either from the cytosolic or cell surface pool, is not cleaved by furin in CHO cells. This result was further confirmed by an inability of furin to cleave in vitro an (35)S-labeled UT-A1 or the 126 N-terminal UT-A1 fragment. Functionally, mutation of the furin site (R78A, R81A) does not affect UT-A1 urea transport activity. However, deletion of the 81-aa N-terminal portion does not affect UT-A1 cell surface trafficking, but seriously impair UT-A1 urea transport activity. Our results indicate that UT-A1 maturation and activation does not require furin-dependent cleavage. The N-terminal 81-aa fragment is required for proper UT-A1 urea transport activity, but its effect is not through changing UT-A1 membrane trafficking.

  20. Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

    Science.gov (United States)

    Wang, Yanhua; Klein, Janet D; Blount, Mitsi A; Martin, Christopher F; Kent, Kimilia J; Pech, Vladimir; Wall, Susan M; Sands, Jeff M

    2009-09-01

    Urea plays a critical role in the concentration of urine, thereby regulating water balance. Vasopressin, acting through cAMP, stimulates urea transport across rat terminal inner medullary collecting ducts (IMCD) by increasing the phosphorylation and accumulation at the apical plasma membrane of UT-A1. In addition to acting through protein kinase A (PKA), cAMP also activates Epac (exchange protein activated by cAMP). In this study, we tested whether the regulation of urea transport and UT-A1 transporter activity involve Epac in rat IMCD. Functional analysis showed that an Epac activator significantly increased urea permeability in isolated, perfused rat terminal IMCD. Similarly, stimulating Epac by adding forskolin and an inhibitor of PKA significantly increased urea permeability. Incubation of rat IMCD suspensions with the Epac activator significantly increased UT-A1 phosphorylation and its accumulation in the plasma membrane. Furthermore, forskolin-stimulated cAMP significantly increased ERK 1/2 phosphorylation, which was not prevented by inhibiting PKA, indicating that Epac mediated this phosphorylation of ERK 1/2. Inhibition of MEK 1/2 phosphorylation decreased the forskolin-stimulated UT-A1 phosphorylation. Taken together, activation of Epac increases urea transport, accumulation of UT-A1 at the plasma membrane, and UT-A1 phosphorylation, the latter of which is mediated by the MEK-ERK pathway.

  1. The First VERITAS Telescope

    CERN Document Server

    Holder, J; Badran, H M; Blaylock, G; Bradbury, S M; Buckley, J H; Byrum, K L; Carter-Lewis, D A; Celik, O; Chow, Y C K; Cogan, P; Cui, W; Daniel, M K; De la Calle-Perez, I; Dowdall, C; Dowkontt, P; Duke, C; Falcone, A D; Fegan, S J; Finley, J P; Fortin, P; Fortson, L F; Gibbs, K; Gillanders, G; Glidewell, O J; Grube, J; Gutíerrez, K J; Gyuk, G; Hall, J; Hanna, D; Hays, E; Horan, D; Hughes, S B; Humensky, T B; Imran, A; Jung, I; Kaaret, Philip; Kenny, G E; Kieda, D; Kildea, J; Knapp, J; Krawczynski, H; Krennrich, F; Lang, M J; Le Bohec, S; Linton, E; Little, E K; Maier, G; Manseri, H; Milovanovic, A; Moriarty, P; Mukherjee, R; Ogden, P A; Ong, R A; Perkins, J S; Pizlo, F; Pohl, M; Quinn, J; Ragan, K; Reynolds, P T; Roache, E T; Rose, H J; Schroedter, M; Sembroski, G H; Sleege, G A; Steele, D; Swordy, S P; Syson, A; Toner, J A; Valcarcel, L; Vasilev, V V; Wagner, R; Wakely, S P; Weekes, T C; White, R J; Williams, D A

    2006-01-01

    The first atmospheric Cherenkov telescope of VERITAS (the Very Energetic Radiation Imaging Telescope Array System) has been in operation since February 2005. We present here a technical description of the instrument and a summary of its performance. The calibration methods are described, along with the results of Monte Carlo simulations of the telescope and comparisons between real and simulated data. The analysis of TeV $\\gamma$-ray observations of the Crab Nebula, including the reconstructed energy spectrum, is shown to give results consistent with earlier measurements. The telescope is operating as expected and has met or exceeded all design specifications.

  2. Liverpool Telescope Spectrum of TCP J01375892+4951055 - A Dwarf Nova in the Andromeda Constellation

    Science.gov (United States)

    Darnley, M. J.; Williams, S. C.; Bode, M. F.

    2016-10-01

    We obtained an optical spectrum of TCP J01375892+4951055 (see CBAT TOCP) with the FRODOSpec spectrograph (Barnsley et al. 2012) on the 2.0m Liverpool Telescope (Steele et al. 2004) on 2016 October 20.06 UT. The spectrum was taken using the lower resolution mode of FRODOSpec, which gives a wavelength coverage of 3900 to 5700 Å and 5800 to 9400 Å, with a resolution of R ~ 2400.

  3. X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope

    CERN Document Server

    Vernet, Joel; D'Odorico, S; Kaper, L; Kjaergaard, P; Hammer, F; Randich, S; Zerbi, F; Groot, P M; Hjorth, J; Guinouard, I; Navarro, R; Adolfse, T; Albers, P W; Amans, J -P; Andersen, J J; Andersen, M I; Binetruy, P; Bristow, P; Castillo, R; Chemla, F; Christensen, L; Conconi, P; Conzelmann, R; Dam, J; De Caprio, V; Postigo, A De Ugarte; Delabre, B; Di Marcantonio, P; Downing, M; Elswijk, E; Finger, G; Fischer, G; Flores, H; Francois, P; Goldoni, P; Guglielmi, L; Haigron, R; Hanenburg, H; Hendriks, I; Horrobin, M; Horville, D; Jessen, N C; Kerber, F; Kern, L; Kiekebusch, M; Kleszcz, P; Klougart, J; Kragt, J; Larsen, H H; Lizon, J -L; Lucuix, C; Mainieri, V; Manuputy, R; Martayan, C; Mason, E; Mazzoleni, R; Michaelsen, N; Modigliani, A; Moehler, S; Møller, P; Sørensen, A Norup; Nørregaard, P; Peroux, C; Patat, F; Pena, E; Pragt, J; Reinero, C; Riga, F; Riva, M; Roelfsema, R; Royer, F; Sacco, G; Santin, P; Schoenmaker, T; Spano, P; Sweers, E; Ter Horst, R; Tintori, M; Tromp, N; van Dael, P; van der Vliet, H; Venema, L; Vidali, M; Vinther, J; Vola, P; Winters, R; Wistisen, D; Wulterkens, G; Zacchei, A

    2011-01-01

    X-shooter is the first 2nd generation instrument of the ESO Very Large Telescope(VLT). It is a very efficient, single-target, intermediate-resolution spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The instrument covers, in a single exposure, the spectral range from 300 to 2500 nm. It is designed to maximize the sensitivity in this spectral range through dichroic splitting in three arms with optimized optics, coatings, dispersive elements and detectors. It operates at intermediate spectral resolution (R~4,000 - 17,000, depending on wavelength and slit width) with fixed echelle spectral format (prism cross-dispersers) in the three arms. It includes a 1.8"x4" Integral Field Unit as an alternative to the 11" long slits. A dedicated data reduction package delivers fully calibrated two-dimensional and extracted spectra over the full wavelength range. We describe the main characteristics of the instrument and present its performance as measured during commissioning, science verification and ...

  4. Depolymerization of cortical actin inhibits UT-A1 urea transporter endocytosis but promotes forskolin-stimulated membrane trafficking.

    Science.gov (United States)

    Xu, Gang; Su, Hua; Carter, Conner B; Fröhlich, Otto; Chen, Guangping

    2012-04-01

    The cytoskeleton participates in many aspects of transporter protein regulation. In this study, by using yeast two-hybrid screening, we identified the cytoskeletal protein actin as a binding partner with the UT-A1 urea transporter. This suggests that actin plays a role in regulating UT-A1 activity. Actin specifically binds to the carboxyl terminus of UT-A1. A serial mutation study shows that actin binding to UT-A1's carboxyl terminus was abolished when serine 918 was mutated to alanine. In polarized UT-A1-MDCK cells, cortical filamentous (F) actin colocalizes with UT-A1 at the apical membrane and the subapical cytoplasm. In the cell surface, both actin and UT-A1 are distributed in the lipid raft microdomains. Disruption of the F-actin cytoskeleton by latrunculin B resulted in UT-A1 accumulation in the cell membrane as measured by biotinylation. This effect was mainly due to inhibition of UT-A1 endocytosis in both clathrin and caveolin-mediated endocytic pathways. In contrast, actin depolymerization facilitated forskolin-stimulated UT-A1 trafficking to the cell surface. Functionally, depolymerization of actin by latrunculin B significantly increased UT-A1 urea transport activity in an oocyte expression system. Our study shows that cortical F-actin not only serves as a structural protein, but directly interacts with UT-A1 and plays an important role in controlling UT-A1 cell surface expression by affecting both endocytosis and trafficking, therefore regulating UT-A1 bioactivity.

  5. LUTE telescope structural design

    Science.gov (United States)

    Ruthven, Gregory

    1993-01-01

    The major objective of the Lunar Ultraviolet Transit Experiment (LUTE) Telescope Structural Design Study was to investigate the feasibility of designing an ultralightweight 1-m aperture system within optical performance requirements and mass budget constraints. This study uses the results from our previous studies on LUTE as a basis for further developing the LUTE structural architecture. After summarizing our results in Section 2, Section 3 begins with the overall logic we used to determine which telescope 'structural form' should be adopted for further analysis and weight estimates. Specific telescope component analysis showing calculated fundamental frequencies and how they compare with our derived requirements are included. 'First-order' component stress analyses to ensure telescope optical and structural component (i.e. mirrors & main bulkhead) weights are realistic are presented. Layouts of both the primary and tertiary mirrors showing dimensions that are consistent with both our weight and frequency calculations also form part of Section 3. Section 4 presents our calculated values for the predicted thermally induced primary-to-secondary mirror despace motion due to the large temperature range over which LUTE must operate. Two different telescope design approaches (one which utilizes fused quartz metering rods and one which assumes the entire telescope is fabricated from beryllium) are considered in this analysis. We bound the secondary mirror focus mechanism range (in despace) based on these two telescope configurations. In Section 5 we show our overall design of the UVTA (Ultraviolet Telescope Assembly) via an 'exploded view' of the sub-system. The 'exploded view' is annotated to help aid in the understanding of each sub-assembly. We also include a two view layout of the UVTA from which telescope and telescope component dimensions can be measured. We conclude our study with a set of recommendations not only with respect to the LUTE structural architecture

  6. Surface electrocardiogram and action potential in mice lacking urea transporter UT-B.

    Science.gov (United States)

    Meng, Yan; Zhao, Chunyan; Zhang, Xuexin; Zhao, Huashan; Guo, Lirong; Lü, Bin; Zhao, Xuejian; Yang, Baoxue

    2009-05-01

    UT-B is a urea transporter protein expressed in the kidney and in many non-renal tissues including erythrocytes, brain, heart, bladder and the testis. The objective of this study was to determine the phenotype of UT-B deletion in the heart. UT-B expression in the heart was studied in wild-type mice vs UT-B null mice by utilizing RT-PCR and Western blot. A surface electrocardiogram (ECG) recording (lead II) was measured in wild-type mice and UT-B null mice at the ages of 6, 16 and 52 weeks. For the action potential recording, the ventricular myocytes of 16 w mice were isolated and recorded by floating microelectrode method. The sodium current was recorded by the patch clamp technique. RT-PCR and Western blot showed the UT-B expression in the heart of wild-type mice. No UT-B transcript and protein was found in UT-B null mice. The ECG recording showed that the P-R interval was significantly prolonged in UT-B null mice ((43.5 +/- 4.2), (45.5 +/- 6.9) and (43.8 +/- 7.6) ms at ages of 6, 16 and 52 weeks) vs wild-type mice ((38.6 +/- 2.9), (38.7 +/- 5.6) and (38.2 +/- 7.3) ms, PUT-B null mice (52 w old). The amplitude of action potential and V (max) decreased significantly in UT-B null mice ((92.17 +/- 10.56) and (101.89 +/- 9.54) mV/s) vs those in wild-type mice (vs (110.51 +/- 10.38) and (109.53 +/- 10.64) mV/s, PUT-B null mice ((123.83 +/- 11.17) and (195.43 +/- 16.41) ms) vs that in wild-type mice ((108.27 +/- 10.85) and (171.00 +/- 15.53) ms, PUT-B null mice (-8.80 +/- 0.92) nA vs that in wild-type mice ((-5.98 +/- 1.07) nA, PUT-B deletion causes progressive heart block in mice.

  7. Water-filled telescopes

    CERN Document Server

    Antonello, E

    2014-01-01

    In this short note we discuss the case of the thought experiments on water-filled telescopes and their realizations during 18th and 19th century. The story of those instruments shows that the scientific progress occurs in a curious way, since there was no stringent reason for the construction of a water-filled telescope.

  8. Surface electrocardiogram and action potential in mice lacking urea transporter UT-B

    Institute of Scientific and Technical Information of China (English)

    MENG Yan; ZHAO ChunYan; ZHANG XueXin; ZHAO HuaShan; GUO LiRong; Lü Bin; ZHAO XueJian; YANG BaoXue

    2009-01-01

    UT-B is a urea transporter protein expressed in the kidney and in many non-renal tissues including erythrocytes, brain, heart, bladder and the testis. The objective of this study was to determine the phenotype of UT-B deletion in the heart. UT-B expression in the heart was studied in wild-type mice vs UT-B null mice by utilizing RT-PCR and Western blot. A surface electrocardiogram (ECG) recording (lead Ⅱ) was measured in wild-type mice and UT-B null mice at the ages of 6, 16 and 52 weeks. For the action potential recording, the ventricular myocytes of 16 w mice were isolated and recorded by float-ing microelectrode method. The sodium current was recorded by the patch clamp technique. RT-PCR and Western blot showed the UT-B expression in the heart of wild-type mice. No UT-B transcript and protein was found in UT-B null mice. The ECG recording showed that the P-R interval was significantly prolonged in UT-B null mice ((43.5±4.2), (45.5±6.9) and (43.8±7.6) ms at ages of 6, 16 and 52 weeks) vs wild-type mice ((38.6±2.9), (38.7±5.6) and (38.2±7.3) ms, P<0.05). The atrial ventricular heart block type Ⅱ and Ⅲ only appeared in the aging UT-B null mice (52 w old). The amplitude of action potential and Vmax decreased significantly in UT-B null mice ((92.17±10.56) and (101.89±9.54) mV/s) vs those in wild-type mice (vs (110.51±10.38) and (109.53±10.64) mV/s, P<0.05). The action potential duration at 50% and 90% (APD50 and APD90) was significantly prolonged in UT-B null mice ((123.83±11.17) and (195.43±16.41) ms) vs that in wild-type mice ((108.27±10.85) and (171.00±15.53) ms, P<0.05). The maximal sodium current decreased significantly in UT-B null mice (-8.80±0.92) nA vs that in wild-type mice ((-5.98±1.07) nA, P<0.05). These results provide the first evidence that UT-B deletion causes progressive heart block in mice.

  9. Surface electrocardiogram and action potential in mice lacking urea transporter UT-B

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    UT-B is a urea transporter protein expressed in the kidney and in many non-renal tissues including erythrocytes, brain, heart, bladder and the testis. The objective of this study was to determine the phenotype of UT-B deletion in the heart. UT-B expression in the heart was studied in wild-type mice vs UT-B null mice by utilizing RT-PCR and Western blot. A surface electrocardiogram (ECG) recording (lead II) was measured in wild-type mice and UT-B null mice at the ages of 6, 16 and 52 weeks. For the action potential recording, the ventricular myocytes of 16 w mice were isolated and recorded by floating microelectrode method. The sodium current was recorded by the patch clamp technique. RT-PCR and Western blot showed the UT-B expression in the heart of wild-type mice. No UT-B transcript and protein was found in UT-B null mice. The ECG recording showed that the P-R interval was significantly prolonged in UT-B null mice ((43.5 ± 4.2), (45.5 ± 6.9) and (43.8 ± 7.6) ms at ages of 6, 16 and 52 weeks) vs wild-type mice ((38.6 ± 2.9), (38.7 ± 5.6) and (38.2 ± 7.3) ms, P<0.05). The atrial ventricular heart block type II and III only appeared in the aging UT-B null mice (52 w old). The amplitude of action potential and Vmax decreased significantly in UT-B null mice ((92.17 ± 10.56) and (101.89 ± 9.54) mV/s) vs those in wild-type mice (vs (110.51 ± 10.38) and (109.53 ± 10.64) mV/s, P<0.05). The action potential duration at 50% and 90% (APD50 and APD90) was significantly prolonged in UT-B null mice ((123.83 ± 11.17) and (195.43 ± 16.41) ms) vs that in wild-type mice ((108.27 ± 10.85) and (171.00 ± 15.53) ms, P<0.05). The maximal sodium current decreased significantly in UT-B null mice (-8.80 ± 0.92) nA vs that in wild-type mice ((-5.98 ± 1.07) nA, P<0.05). These results provide the first evidence that UT-B deletion causes progressive heart block in mice.

  10. Observing the Sun with Coronado telescopes telescopes

    CERN Document Server

    Pugh, Philip

    2007-01-01

    The Sun provides amateur astronomers with one of the few opportunities for daytime astronomy. In order to see the major features of our nearest star, special telescopes that have a very narrow visible bandwidth are essential. The bandwidth has to be as narrow as 1 A- 10-10 m (1 Angstrom) and centred on the absorption line of neutral hydrogen. This makes many major features of the Suna (TM)s chromosphere visible to the observer. Such narrow-band "Fabry-Perot etalon filters" are high technology, and until the introduction of the Coronado range of solar telescopes, were too expensive for amateur use. The entry-level Coronado telescope, the PST (Personal Solar Telescope) costs under 500. Solar prominences (vast columns of plasma, best seen at the edge of the solar disk), filaments, flares, sunspots, plage and active regions are all visible and can be imaged to produce spectacular solar photographs. Philip Pugh has assembled a team of contributors who show just how much solar work can be done with Coronado telesco...

  11. Southern Fireworks above ESO Telescopes

    Science.gov (United States)

    1999-05-01

    New Insights from Observations of Mysterious Gamma-Ray Burst International teams of astronomers are now busy working on new and exciting data obtained during the last week with telescopes at the European Southern Observatory (ESO). Their object of study is the remnant of a mysterious cosmic explosion far out in space, first detected as a gigantic outburst of gamma rays on May 10. Gamma-Ray Bursters (GRBs) are brief flashes of very energetic radiation - they represent by far the most powerful type of explosion known in the Universe and their afterglow in optical light can be 10 million times brighter than the brightest supernovae [1]. The May 10 event ranks among the brightest one hundred of the over 2500 GRB's detected in the last decade. The new observations include detailed images and spectra from the VLT 8.2-m ANTU (UT1) telescope at Paranal, obtained at short notice during a special Target of Opportunity programme. This happened just over one month after that powerful telescope entered into regular service and demonstrates its great potential for exciting science. In particular, in an observational first, the VLT measured linear polarization of the light from the optical counterpart, indicating for the first time that synchrotron radiation is involved . It also determined a staggering distance of more than 7,000 million light-years to this GRB . The astronomers are optimistic that the extensive observations will help them to better understand the true nature of such a dramatic event and thus to bring them nearer to the solution of one of the greatest riddles of modern astrophysics. A prime example of international collaboration The present story is about important new results at the front-line of current research. At the same time, it is also a fine illustration of a successful collaboration among several international teams of astronomers and the very effective way modern science functions. It began on May 10, at 08:49 hrs Universal Time (UT), when the Burst

  12. Small GTPase Rab14 down-regulates UT-A1 urea transport activity through enhanced clathrin-dependent endocytosis.

    Science.gov (United States)

    Su, Hua; Liu, Bingchen; Fröhlich, Otto; Ma, Heping; Sands, Jeff M; Chen, Guangping

    2013-10-01

    The UT-A1 urea transporter plays an important role in the urinary concentration mechanism. However, the molecular mechanisms regarding UT-A1 trafficking, endocytosis, and degradation are still unclear. In this study, we identified the small GTPase Rab14 as a binding partner to the C terminus of UT-A1 in a yeast 2-hybrid assay. Interestingly, UT-A1 binding is preferential for the GDP-bound inactive form of Rab14. Coinjection of Rab14 in Xenopus oocytes results in a decrease of UT-A1 urea transport activity, suggesting that Rab14 acts as a negative regulator of UT-A1. We subsequently found that Rab14 reduces the cell membrane expression of UT-A1, as evidenced by cell surface biotinylation. This effect is blocked by chlorpromazine, an inhibitor of the clathrin-mediated endocytic pathway, but not by filipin, an inhibitor of the caveolin-mediated endocytic pathway. In kidney, Rab14 is mainly expressed in IMCD epithelial cells with a pattern identical to UT-A1 expression. Consistent with its role in participating in clathrin-mediated endocytosis, Rab14 localizes in nonlipid raft microdomains and codistributes with Rab5, a marker of the clathrin-mediated endocytic pathway. Taken together, our study suggests that Rab14, as a novel UT-A1 partner, may have an important regulatory function for UT-A1 urea transport activity in the kidney inner medulla.

  13. Field Evaluations of Low-Frequency SAFT-UT on Cast Stainless Steel and Dissimilar Metal Weld Components

    Energy Technology Data Exchange (ETDEWEB)

    Diaz, Aaron A.; Harris, R. V.; Doctor, Steven R.

    2008-11-01

    This report documents work performed at the Pacific Northwest National Laboratory (PNNL) in Richland, Washington, and at the Electric Power Research Institute's (EPRI) Nondestructive Examination (NDE) Center in Charlotte, North Carolina, on evalutating a low frequency ultrasonic inspection technique used for examination of cast stainless steel (CSS) and dissimilar metal (DMW) reactor piping components. The technique uses a zone-focused, multi-incident angle, low frequency (250-450 kHz) inspection protocol coupled with the synthetic aperture focusing technique (SAFT). The primary focus of this work is to provide information to the United States Nuclear Regulatory Commission on the utility, effectiveness and reliability of ultrasonic testing (UT) inspection techniques as related to the inservice ultrasonic inspection of coarse grained primary piping components in pressurized water reactors (PWRs).

  14. Two Easily Made Astronomical Telescopes.

    Science.gov (United States)

    Hill, M.; Jacobs, D. J.

    1991-01-01

    The directions and diagrams for making a reflecting telescope and a refracting telescope are presented. These telescopes can be made by students out of plumbing parts and easily obtainable, inexpensive, optical components. (KR)

  15. Real-time 3-D SAFT-UT system evaluation and validation

    Energy Technology Data Exchange (ETDEWEB)

    Doctor, S.R.; Schuster, G.J.; Reid, L.D.; Hall, T.E. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-09-01

    SAFT-UT technology is shown to provide significant enhancements to the inspection of materials used in US nuclear power plants. This report provides guidelines for the implementation of SAFT-UT technology and shows the results from its application. An overview of the development of SAFT-UT is provided so that the reader may become familiar with the technology. Then the basic fundamentals are presented with an extensive list of references. A comprehensive operating procedure, which is used in conjunction with the SAFT-UT field system developed by Pacific Northwest Laboratory (PNL), provides the recipe for both SAFT data acquisition and analysis. The specification for the hardware implementation is provided for the SAFT-UT system along with a description of the subsequent developments and improvements. One development of technical interest is the SAFT real time processor. Performance of the real-time processor is impressive and comparison is made of this dedicated parallel processor to a conventional computer and to the newer high-speed computer architectures designed for image processing. Descriptions of other improvements, including a robotic scanner, are provided. Laboratory parametric and application studies, performed by PNL and not previously reported, are discussed followed by a section on field application work in which SAFT was used during inservice inspections of operating reactors.

  16. Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct.

    Science.gov (United States)

    Hoban, Carol A; Black, Lauren N; Ordas, Ronald J; Gumina, Diane L; Pulous, Fadi E; Sim, Jae H; Sands, Jeff M; Blount, Mitsi A

    2015-01-01

    Vasopressin signaling is critical for the regulation of urea transport in the inner medullary collecting duct (IMCD). Increased urea permeability is driven by a vasopressin-mediated elevation of cAMP that results in the direct phosphorylation of urea transporter (UT)-A1. The identification of cAMP-sensitive phosphorylation sites, Ser(486) and Ser(499), in the rat UT-A1 sequence was the first step in understanding the mechanism of vasopressin action on the phosphorylation-dependent modulation of urea transport. To investigate the significance of multisite phosphorylation of UT-A1 in response to elevated cAMP, we used highly specific and sensitive phosphosite antibodies to Ser(486) and Ser(499) to determine cAMP action at each phosphorylation site. We found that phosphorylation at both sites was rapid and sustained. Furthermore, the rate of phosphorylation of the two sites was similar in both mIMCD3 cells and rat inner medullary tissue. UT-A1 localized to the apical membrane in response to vasopressin was phosphorylated at Ser(486) and Ser(499). We confirmed that elevated cAMP resulted in increased phosphorylation of both sites by PKA but not through the vasopressin-sensitive exchange protein activated by cAMP pathway. These results elucidate the multisite phosphorylation of UT-A1 in response to cAMP, thus providing the beginning of understanding the intracellular factors underlying vasopressin stimulation of urea transport in the IMCD.

  17. The James Webb Space Telescope

    Science.gov (United States)

    Gardner, Jonathan P.

    2011-01-01

    The James Webb Space Telescope is the scientific successor to the Hubble and Spitzer Space Telescopes, and is currently the largest scientific project under construction in the United States. It will be a large (6.6m) cold (50K) telescope launched into orbit around the second Earth-Sun Lagrange point. It is a partnership of NASA with the European and Canadian Space Agencies. Science with the James Webb Space Telescope falls into four themes. The End of the Dark Ages: First Light and Reionization theme seeks to identify the first luminous sources to form and to determine the ionization history of the universe. The Assembly of Galaxies theme seeks to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and black holes within them evolved from the epoch of reionization to the present. The Birth of Stars and Protoplanetary Systems theme seeks to unravel the birth and early evolution of stars, from infall onto dust-enshrouded protostars, to the genesis of planetary systems. The Planetary Systems and the Origins of Life theme seeks to determine the physical and chemical properties of planetary systems around nearby stars and of our own, and investigate the potential for life in those systems. Webb will have four instruments: The Near-Infrared Camera, the Near-Infrared multi-object Spectrograph, and the Tunable Filter Imager will cover the wavelength range 0.6 to 5 microns, while the Mid-Infrared Instrument will do both imaging and spectroscopy from 5 to 28.5 microns. I will conclude the talk with a description of recent technical progress in the construction of the observatory.

  18. The AMANDA neutrino telescope

    Energy Technology Data Exchange (ETDEWEB)

    Andres, E.C.; Askebjer, P.; Barwick, S.W.; Bay, R.C.; Bergstrom,L.; Biron, A.; Booth, J.; Botner, O.; Bouchta, A.; Carius, S.; Carlson,M.; Chinowsky, W.; Chirkin, D.; Conrad,J.; Costa, C.G.S.; Cowen, D.; Dalberg, E.; DeYoung, T.; Edsjo, J.; Ekstrom, P.; Goobar, A.; Gray, L.; Hallgren, A.; Halzen, F.; Hardtke, R.; Hart, S.; He, Y.; de, los, Heros,C.P.; Hill, G.; Hulth, PO.; Hundertmark, S.; Jacobsen, J.; Jones, A.; Kandhadai, V.; Karle, A.; Kim, J.; Leich, H.; Leuthold, M.; Lindahl, P.; Liubarsky, I.; Loaiza, P.; Lowder, D.; Marciniewski, P.; Miller, T.C.; Miocinovic, P.; Mock, P.C.; Morse, R.; Newcomer, M.; Niessen, P.; Nygren,D.; Porrata, R.; Potter, D.; Price, P.B.; Przybylski, G.; Rhode, W.; Richter, S.; Rodriguez, J.; Romenesko, P.; Ross, D.; Rubinstein, H.; Schmidt, T.; Schneider, E.; Schwarz, R.; Schwendicke, U.; Smoot, G.; Solarz, M.; Sorin, V.; Spiering, C.; Steffen, P.; Stokstad, R.; Streicher, O.; Taboada, I.; Thon, T.; Tilav, S.; Walck, C.; Wiebusch,C.H.; Wischnewski, R.; Woschnagg, K.; Wu, W.; Yodh, G.; Young, S.; AMANDACollaboration

    1999-04-01

    With an effective telescope area of order 10(4) m(2) for TeVneutrinos, a threshold near similar to 50 GeV and a pointing accuracy of2.5 degrees per muon track, the AMANDA detector represents the first of anew generation of high energy neutrino telescopes, reaching a scaleenvisaged over 25 years ago. We describe early results on the calibrationof natural deep ice as a particle detector as well as on AMANDA'sperformance as a neutrino telescope.

  19. The AMANDA neutrino telescope

    Energy Technology Data Exchange (ETDEWEB)

    Andres, E.C.; Askebjer, P.; Barwick, S.W.; Bay, R.C.; Bergstroem, L.; Biron, A.; Booth, J.; Botner, O.; Bouchta, A.; Carius, S.; Carlson, M.; Chinowsky, W.; Chirkin, D.; Conrad, J.; Costa, C.G.S.; Cowen, D.; Dalberg, E.; DeYoung, T.; Edsjoe, J.; Ekstroem, P.; Goobar, A.; Gray, L.; Hallgren, A.; Halzen, F.; Hardtke, R.; Hart, S.; He, Y.; Heros, C.P. de los; Hill, G.; Hulth, P.O.; Hundertmark, S.; Jacobsen, J.; Jones, A.; Kandhadai, V.; Karle, A.; Kim, J.; Leich, H.; Leuthold, M.; Lindahl, P.; Liubarsky, I.; Loaiza, P.; Lowder, D.; Marciniewski, P.; Miller, T.C.; Miocinovic, P.; Mock, P.C.; Morse, R.; Newcomer, M.; Niessen, P.; Nygren, D.; Porrata, R.; Potter, D.; Price, P.B.; Przybylski, G.; Rhode, W.; Richter, S.; Rodriquez, J.; Romenesko, P.; Ross, D.; Rubinstein, H.; Schmidt, T.; Schneider, E.; Schwartz, R.; Schwendicke, U.; Smoot, G.; Solarz, M.; Sorin, V.; Spiering, C.; Steffen, P.; Stokstad, R.; Streicher, O.; Taboada, I.; Thon, T.; Tilav, S.; Walck, C.; Wiebusch, C.H.; Wischnewski, R.; Woschnagg, K.; Wu, W.; Yodh, G.; Young, S

    1999-05-01

    With an effective telescope area of order 10{sup 4} m{sup 2} for TeV neutrinos, a threshold near {approx}50 GeV and a pointing accuracy of 2.5 degrees per muon track, the AMANDA detector represents the first of a new generation of high energy neutrino telescopes, reaching a scale envisaged over 25 years ago. We describe early results on the calibration of natural deep ice as a particle detector as well as on AMANDA's performance as a neutrino telescope.

  20. Modular assembled space telescope

    Science.gov (United States)

    Feinberg, Lee D.; Budinoff, Jason; MacEwen, Howard; Matthews, Gary; Postman, Marc

    2013-09-01

    We present a new approach to building a modular segmented space telescope that greatly leverages the heritage of the Hubble Space Telescope and the James Webb Space Telescope. The modular design in which mirror segments are assembled into identical panels allows for economies of scale and for efficient space assembly that make a 20-m aperture approach cost effective. This assembly approach can leverage NASA's future capabilities and has the power to excite the public's imagination. We discuss the science drivers, basic architecture, technology, and leveraged NASA infrastructure, concluding with a proposed plan for going forward.

  1. nUt=4Dt补图的色等价刻画%The Chromatically Equivalent Depiction of nUt=4Dt

    Institute of Scientific and Technical Information of China (English)

    冶成福

    2009-01-01

    用β(G)表示伴随多项式h(G,x)的最小实根,本文研究了满足条件β(G)≥β(Dn)的图G的范围,应用这个结果完整刻画了图nUt=4Dt的补图的色等价图类,并得到此类图色唯一的条件.

  2. Goddard Robotic Telescope (GRT)

    Data.gov (United States)

    National Aeronautics and Space Administration — Since it is not possible to predict when a Gamma-Ray Burst (GRB) occurs, the follow-up ground telescopes must be distributed as uniform as possible all over the...

  3. Parabolic Strip Telescope

    CERN Document Server

    Chadzitaskos, Goce

    2013-01-01

    We present a proposal of a new type of telescopes using a rotating parabolic strip as the primary mirror. It is the most principal modification of the design of telescopes from the times of Galileo and Newton. In order to demonstrate the basic idea, the image of an artificial constellation observed by this kind of telescope was reconstructed using the techniques described in this article. As a working model of this new telescope, we have used an assembly of the primary mirror---a strip of acrylic glass parabolic mirror 40 cm long and 10 cm wid shaped as a parabolic cylinder of focal length 1 m---and an artificial constellation, a set of 5 apertures in a distance of 5 m illuminated from behind. In order to reconstruct the image, we made a series of snaps, each after a rotation of the constellation by 15 degrees. Using Matlab we reconstructed the image of the artificial constellation.

  4. The Dark Matter Telescope

    CERN Document Server

    Tyson, J A; Angel, J R P; Wittman, David

    2001-01-01

    Weak gravitational lensing enables direct reconstruction of dark matter maps over cosmologically significant volumes. This research is currently telescope-limited. The Dark Matter Telescope (DMT) is a proposed 8.4 m telescope with a 3 degree field of view, with an etendue of 260 $(m. degree)^2$, ten times greater than any other current or planned telescope. With its large etendue and dedicated observational mode, the DMT fills a nearly unexplored region of parameter space and enables projects that would take decades on current facilities. The DMT will be able to reach 10-sigma limiting magnitudes of 27-28 magnitude in the wavelength range .3 - 1 um over a 7 square degree field in 3 nights of dark time. Here we review its unique weak lensing cosmology capabilities and the design that enables those capabilities.

  5. Large Binocular Telescope Project

    Science.gov (United States)

    Hill, John M.

    1997-03-01

    The large binocular telescope (LBT) project have evolved from concepts first proposed in 1985. The present partners involved in the design and construction of this 2 by 8.4 meter binocular telescope are the University of Arizona, Italy represented by the Osservatorio Astrofisico di Arcetri and the Research Corporation based in Tucson, Arizona. These three partners have committed sufficient funds to build the enclosure and the telescope populated with a single 8.4 meter optical train -- approximately 40 million dollars (1989). Based on this commitment, design and construction activities are now moving forward. Additional partners are being sought. The next mirror to be cast at the Steward Observatory Mirror Lab in the fall of 1996 will be the first borosilicate honeycomb primary for LBT. The baseline optical configuration of LBT includes wide field Cassegrain secondaries with optical foci above the primaries to provide a corrected one degree field at F/4. The infrared F/15 secondaries are a Gregorian design to allow maximum flexibility for adaptive optics. The F/15 secondaries are undersized to provide a low thermal background focal plane which is unvignetted over a 4 arcminute diameter field-of-view. The interferometric focus combining the light from the two 8.4 meter primaries will reimage two folded Gregorian focal planes to a central location. The telescope elevation structure accommodates swing arms which allow rapid interchange of the various secondary and tertiary mirrors. Maximum stiffness and minimal thermal disturbance continue to be important drivers for the detailed design of the telescope. The telescope structure accommodates installation of a vacuum bell jar for aluminizing the primary mirrors in-situ on the telescope. The detailed design of the telescope structure will be completed in 1996 by ADS Italia (Lecco) and European Industrial Engineering (Mestre). The final enclosure design is now in progress at M3 Engineering (Tucson), EIE and ADS Italia

  6. Accuracy assessment of the UT1 prediction method based on 100-year series analysis

    CERN Document Server

    Malkin, Z; Tolstikov, A

    2013-01-01

    A new method has been developed at the Siberian Research Institute of Metrology (SNIIM) for highly accurate prediction of UT1 and Pole coordinates. The method is based on construction of a general polyharmonic model of the variations of the Earth rotation parameters using all the data available for the last 80-100 years, and modified autoregression technique. In this presentation, a detailed comparison was made of real-time UT1 predictions computed making use of this method in 2006-2010 with simultaneous predictions computed at the International Earth Rotation and Reference Systems Service (IERS). Obtained results have shown that proposed method provides better accuracy at different prediction lengths.

  7. The Multiple-Mirror Telescope

    Science.gov (United States)

    Carleton, Nathaniel P.; Hoffmann, William F.

    1978-01-01

    Describes the basic design and principle of operating an optical-infrared telescope, the MMT. This third largest telescope in the world represents a new stage in telescope design; it uses a cluster of six reflecting telescopes, and relies on an automatic sensing and control system. (GA)

  8. Targeted overexpression of the human urotensin receptor transgene in smooth muscle cells: effect of UT antagonism in ApoE knockout mice fed with Western diet.

    Science.gov (United States)

    Papadopoulos, Panayiota; Bousette, Nicolas; Al-Ramli, Wisam; You, Zhipeng; Behm, David J; Ohlstein, Eliot H; Harrison, Stephen M; Douglas, Stephen A; Giaid, Adel

    2009-06-01

    Urotensin II (UII) and its receptor UT are upregulated in the pathological setting of various cardiovascular diseases including atherosclerosis. However, their exact role in atherosclerosis remains to be determined. In the present study we used four strains of mice; wild-type (WT), UT(+) (a transgenic strain expressing human UT driven by the alpha-smooth muscle-specific, SM22, promoter), ApoE knockout (ko), and UT(+)/ApoE ko. All animals were fed high fat diet for 12 weeks. Western blot analysis revealed a significant increase in aortic UT expression in UT(+) relative to WT mice (PUT protein level to that of UT(+). Immunohistochemistry revealed the presence of strong expression of UT and UII proteins in the atheroma of UT(+), ApoE ko and UT(+)/ApoE ko mice, particularly in foam cells. Serum cholesterol and triglyceride levels were significantly increased in ApoE ko and in UT(+)/ApoE ko but not in UT(+) mice when compared to WT mice (PUT(+), ApoE ko and UT(+)/ApoE ko compared to WT mice (PUT receptor antagonist SB-657510A (30 microg/Kg/day gavage) for 10 weeks in a group of ApoE ko mice fed on high fat diet resulted in a significant reduction of lesion (PUT in the pathogenesis of atherosclerosis. The use of UT receptor antagonists may provide a beneficial tool in the management of this debilitating disease process.

  9. Activation of the cAMP/PKA pathway induces UT-A1 urea transporter monoubiquitination and targets it for lysosomal degradation.

    Science.gov (United States)

    Su, Hua; Chen, Minguang; Sands, Jeff M; Chen, Guangping

    2013-12-15

    Regulation of urea transporter UT-A1 in the kidney is important for the urinary concentrating mechanism. We previously reported that activation of the cAMP/PKA pathway by forskolin (FSK) leads to UT-A1 ubiquitination, endocytosis, and degradation. In this study, we discovered that FSK-induced UT-A1 ubiquitination is monoubiquitination as judged by immunoblotting with specific ubiquitin antibodies to the different linkages of the ubiquitin chain. UT-A1 monoubiquitination induced by FSK was processed mainly on the cell plasma membrane. Monoubiquitination facilitates UT-A1 endocytosis, and internalized UT-A1 is accumulated in the early endosome. Inhibition of ubiquitination by E1 ubiquitin-activating enzyme inhibitor PYR-41 significantly reduced FSK-induced UT-A1 endocytosis and degradation. Interestingly, FSK-stimulated UT-A1 degradation occurs through a lysosomal protein degradation system. We further found that the PKA phosphorylation sites of UT-A1 at Ser486 and Ser499 are required for FSK-induced UT-A1 monoubiquitination. The physiological significance was confirmed using rat kidney inner medullary collecting duct suspensions, which showed that vasopressin treatment promotes UT-A1 ubiquitination. We conclude that unlike under basal conditions in which UT-A1 is subject to polyubiquitination and proteasome-mediated protein degradation, activation of UT-A1 by FSK induces UT-A1 monoubiquitination and protein lysosomal degradation.

  10. Robotic and Survey Telescopes

    Science.gov (United States)

    Woźniak, Przemysław

    Robotic telescopes are revolutionizing the way astronomers collect their dataand conduct sky surveys. This chapter begins with a discussion of principles thatguide the process of designing, constructing, and operating telescopes andobservatories that offer a varying degree of automation, from instruments remotelycontrolled by observers to fully autonomous systems requiring no humansupervision during their normal operations. Emphasis is placed on designtrade-offs involved in building end-to-end systems intended for a wide range ofscience applications. The second part of the chapter contains descriptions ofseveral projects and instruments, both existing and currently under development.It is an attempt to provide a representative selection of actual systems thatillustrates state of the art in technology, as well as important ideas and milestonesin the development of the field. The list of presented instruments spans the fullrange in size starting from small all-sky monitors, through midrange robotic andsurvey telescopes, and finishing with large robotic instruments and surveys.Explosive growth of telescope networking is enabling entirely new modesof interaction between the survey and follow-up observing. Increasingimportance of standardized communication protocols and software is stressed.These developments are driven by the fusion of robotic telescope hardware,massive storage and databases, real-time knowledge extraction, and datacross-correlation on a global scale. The chapter concludes with examplesof major science results enabled by these new technologies and futureprospects.

  11. The South Pole Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Ruhl, J.E.; Ade, P.A.R.; Carlstrom, J.E.; Cho, H.M.; Crawford,T.; Dobbs, M.; Greer, C.H.; Halverson, N.W.; Holzapfel, W.L.; Lanting,T.M.; Lee, A.T.; Leitch, E.M.; Leong, J.; Lu, W.; Lueker, M.; Mehl, J.; Meyer, S.S.; Mohr, J.J.; Padin, S.; Plagge, T.; Pryke, C.; Runyan, M.C.; Schwan, D.; Sharp, M.K.; Spieler, H.; Staniszewski, Z.; Stark, A.A.

    2004-11-04

    A new 10 meter diameter telescope is being constructed for deployment at the NSF South Pole research station. The telescope is designed for conducting large-area millimeter and sub-millimeter wave surveys of faint, low contrast emission, as required to map primary and secondary anisotropies in the cosmic microwave background. To achieve the required sensitivity and resolution, the telescope design employs an off-axis primary with a 10 m diameter clear aperture. The full aperture and the associated optics will have a combined surface accuracy of better than 20 microns rms to allow precision operation in the submillimeter atmospheric windows. The telescope will be surrounded with a large reflecting ground screen to reduce sensitivity to thermal emission from the ground and local interference. The optics of the telescope will support a square degree field of view at 2mm wavelength and will feed a new 1000-element micro-lithographed planar bolometric array with superconducting transition-edge sensors and frequency-multiplexed readouts. The first key project will be to conduct a survey over 4000 degrees for galaxy clusters using the Sunyaev-Zeldovich Effect. This survey should find many thousands of clusters with a mass selection criteria that is remarkably uniform with redshift. Armed with redshifts obtained from optical and infrared follow-up observations, it is expected that the survey will enable significant constraints to be placed on the equation of state of the dark energy.

  12. The Travelling Telescope

    Science.gov (United States)

    Murabona Oduori, Susan

    2015-08-01

    The telescope has been around for more than 400 years, and through good use of it scientists have made many astonishing discoveries and begun to understand our place in the universe. Most people, however, have never looked through one. Yet it is a great tool for cool science and observation especially in a continent and country with beautifully dark skies. The Travelling Telescope project aims to invite people outside under the stars to learn about those curious lights in the sky.The Travelling Telescope aims to promote science learning to a wide range of Kenyan schools in various locations exchanging knowledge about the sky through direct observations of celestial bodies using state of the art telescopes. In addition to direct observing we also teach science using various hands-on activities and astronomy software, ideal for explaining concepts which are hard to understand, and for a better grasp of the sights visible through the telescope. We are dedicated to promoting science using astronomy especially in schools, targeting children from as young as 3 years to the youth, teachers, their parents and members of the public. Our presentation focuses on the OAD funded project in rural coastal Kenya.

  13. The South Pole Telescope

    CERN Document Server

    Ruhl, J E; Carlstrom, J E; Cho, H M; Crawford, T; Dobbs, M; Greer, C H; Halverson, W; Holzapfel, W L; Lanting, T M; Lee, A T; Leong, J; Leitch, E M; Lu, W; Lueker, M; Mehl, J; Meyer, S S; Mohr, J J; Padin, S; Plagge, T; Pryke, C L; Schwan, D; Sharp, M K; Runyan, M C; Spieler, H; Staniszewski, Z; Stark, A A

    2004-01-01

    A new 10 meter diameter telescope is being constructed for deployment at the NSF South Pole research station. The telescope is designed for conducting large-area millimeter and sub-millimeter wave surveys of faint, low contrast emission, as required to map primary and secondary anisotropies in the cosmic microwave background. To achieve the required sensitivity and resolution, the telescope design employs an off-axis primary with a 10m diameter clear aperture. The full aperture and the associated optics will have a combined surface accuracy of better than 20 microns rms to allow precision operation in the submillimeter atmospheric windows. The telescope will be surrounded with a large reflecting ground screen to reduce sensitivity to thermal emission from the ground and local interference. The optics of the telescope will support a square degree field of view at 2mm wavelength and will feed a new 1000-element micro-lithographed planar bolometric array with superconducting transition-edge sensors and frequency...

  14. Os utópicos como pioneiros da concepção cooperativista

    Directory of Open Access Journals (Sweden)

    Elisa Zwick

    2016-11-01

    Full Text Available Este estudo tematiza as ideias pioneiras dos principais socialistas utópicos (Saint-Simon, Charles Fourier e Robert Owen na concepção de cooperativismo, de modo que buscamos contribuir para o preenchimento de uma lacuna nos estudos teóricos sobre o assunto no Brasil, não raro dominados por estudos técnico-operacionais. As ideias dos utópicos inauguraram uma sustentação teórica para o cooperativismo pensado não apenas para fins imediatos, mas como paradigma que servisse para alterar a configuração social geral. Além de assinalar as contribuições pioneiras dos pensadores utópicos na concepção do cooperativismo, apontamos que os princípios organizacionais e administrativos dos utópicos antecederam, em termos de conceito e tempo, a Teoria Clássica da Administração Científica.

  15. BET bromodomain inhibition rescues erythropoietin differentiation of human erythroleukemia cell line UT7

    Energy Technology Data Exchange (ETDEWEB)

    Goupille, Olivier [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Penglong, Tipparat [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Thalassemia Research Center and Department of Clinical Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University (Thailand); Lefevre, Carine; Granger, Marine; Kadri, Zahra [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Fucharoen, Suthat [Thalassemia Research Center and Department of Clinical Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University (Thailand); Maouche-Chretien, Leila [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Leboulch, Philippe [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France); Genetics Division, Department of Medicine, Brigham and Women' s Hospital and Harvard Medical School, Boston, MA (United States); Chretien, Stany, E-mail: stany.chretien@cea.fr [CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay-aux-Roses (France); UMR INSERM U.962, University Paris XI, CEA, Fontenay-aux-Roses (France)

    2012-12-07

    Highlights: Black-Right-Pointing-Pointer UT7 erythroleukemia cells are known to be refractory to differentiate. Black-Right-Pointing-Pointer Brief JQ1 treatment initiates the first steps of erythroid differentiation program. Black-Right-Pointing-Pointer Engaged UT7 cells then maturate in the presence of erythropoietin. Black-Right-Pointing-Pointer Sustained JQ1 treatment inhibits both proliferation and erythroid differentiation. -- Abstract: Malignant transformation is a multistep process requiring oncogenic activation, promoting cellular proliferation, frequently coupled to inhibition of terminal differentiation. Consequently, forcing the reengagement of terminal differentiation of transformed cells coupled or not with an inhibition of their proliferation is a putative therapeutic approach to counteracting tumorigenicity. UT7 is a human leukemic cell line able to grow in the presence of IL3, GM-CSF and Epo. This cell line has been widely used to study Epo-R/Epo signaling pathways but is a poor model for erythroid differentiation. We used the BET bromodomain inhibition drug JQ1 to target gene expression, including that of c-Myc. We have shown that only 2 days of JQ1 treatment was required to transitory inhibit Epo-induced UT7 proliferation and to restore terminal erythroid differentiation. This study highlights the importance of a cellular erythroid cycle break mediated by c-Myc inhibition before initiation of the erythropoiesis program and describes a new model for BET bromodomain inhibitor drug application.

  16. 75 FR 81190 - Television Broadcasting Services; Vernal and Santaquin, UT, and Ely and Caliente, NV

    Science.gov (United States)

    2010-12-27

    ... COMMISSION 47 CFR Part 73 Television Broadcasting Services; Vernal and Santaquin, UT, and Ely and Caliente.... The Commission was required by the DTV Delay Act to ] terminate all licenses for full-power television... Commission no longer has the authority to act on rulemaking proposals in the full-power analog...

  17. Guided UT wave inspection of insulated feedwater piping using magnetostrictive sensors

    Science.gov (United States)

    Brophy, J. W.; Brett, Colin R.

    1996-11-01

    Due to failures in power plant feedwater piping, inspection of these components has become a priority item. The major reason for the failures is wall loss due to flow-accelerated corrosion on the inside diameter (ID) of the pipes. It can be very costly to use standard nondestructive testing (NDT) techniques for a comprehensive inspection due to the need to remove large areas of insulation. Guided UT waves can travel through the pipe over long distances and detect cross- sectional changes in the pipe wall with minimal insulation removal. This makes the guided UT wave an excellent candidate for locating significant wall loss due to corrosion and pitting. Southwest Research Institute (SwRI) has developed a simple and robust technology for generating and receiving guided UT waves based on magnetorestrictive sensors. Signals are generated and detected in the pipe via multi-turn coils acting as transmitters and receivers. Insulation removal is only required where the coils are attached to the pipe and this allows many meters of pipe to be inspected from a single location. Guided UT waves detect cross-sectional changes from corrosion on both the ID and outside diameter of the pipe and can also be used to map weld locations. This paper describes SwRIs systems and the preliminary results from testing on a feedwater pipe mockup containing simulated flow-accelerated corrosion.

  18. The Variable Stiffness Actuator vsaUT-II: Mechanical Design, Modeling, and Identification

    NARCIS (Netherlands)

    Groothuis, Stefan; Rusticelli, Giacomo; Zucchelli, Andrea; Stramigioli, Stefano; Carloni, Raffaella

    In this paper, the rotational variable stiffness actuator vsaUT-II is presented. This actuation system is characterized by the property that the apparent stiffness at the actuator output can be varied independently from its position. This behavior is realized by implementing a variable transmission

  19. 75 FR 38768 - Ashley National Forest, UT, High Uintas Wilderness-Colorado River Cutthroat Trout Habitat...

    Science.gov (United States)

    2010-07-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Ashley National Forest, UT, High Uintas Wilderness--Colorado River Cutthroat Trout Habitat Enhancement AGENCY: Forest Service, USDA. ACTION: Notice of intent to prepare an environmental...

  20. Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.

    Science.gov (United States)

    Anderson, Marc O; Zhang, Jicheng; Liu, Yan; Yao, Chenjuan; Phuan, Puay-Wah; Verkman, A S

    2012-06-28

    Urea transporters, which include UT-B in kidney microvessels, are potential targets for development of drugs with a novel diuretic ('urearetic') mechanism. We recently identified, by high-throughput screening, a triazolothienopyrimidine UT-B inhibitor, 1, that selectively and reversibly inhibited urea transport with IC(50) = 25.1 nM and reduced urinary concentration in mice ( Yao et al. J. Am. Soc. Nephrol. , in press ). Here, we analyzed 273 commercially available analogues of 1 to establish a structure-activity series and synthesized a targeted library of 11 analogues to identify potent, metabolically stable UT-B inhibitors. The best compound, {3-[4-(1,1-difluoroethyl)benzenesulfonyl]thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-yl}thiophen-2-ylmethylamine, 3k, had IC(50) of 23 and 15 nM for inhibition of urea transport by mouse and human UT-B, respectively, and ∼40-fold improved in vitro metabolic stability compared to 1. In mice, 3k accumulated in kidney and urine and reduced maximum urinary concentration. Triazolothienopyrimidines may be useful for therapy of diuretic-refractory edema in heart and liver failure.

  1. 75 FR 6625 - Dixie National Forest, UT, Kitty Hawk Administrative Site Master Development Plan

    Science.gov (United States)

    2010-02-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Dixie National Forest, UT, Kitty Hawk Administrative Site Master Development Plan AGENCY: Forest Service, USDA. ACTION: Notice of Intent to Prepare an Environmental Impact Statement. SUMMARY:...

  2. 78 FR 19520 - Notice of Invitation to Participate In Coal Exploration License Application UTU-89492, UT

    Science.gov (United States)

    2013-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Land Management Notice of Invitation to Participate In Coal Exploration License Application UTU-89492, UT AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: All...

  3. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.

    Science.gov (United States)

    Esteva-Font, Cristina; Cil, Onur; Phuan, Puay-Wah; Su, Tao; Lee, Sujin; Anderson, Marc O; Verkman, A S

    2014-09-01

    Urea transport (UT) proteins of the UT-A class are expressed in epithelial cells in kidney tubules, where they are required for the formation of a concentrated urine by countercurrent multiplication. Here, using a recently developed high-throughput assay to identify UT-A inhibitors, a screen of 50,000 synthetic small molecules identified UT-A inhibitors of aryl-thiazole, γ-sultambenzosulfonamide, aminocarbonitrile butene, and 4-isoxazolamide chemical classes. Structure-activity analysis identified compounds that inhibited UT-A selectively by a noncompetitive mechanism with IC50 down to ∼1 μM. Molecular modeling identified putative inhibitor binding sites on rat UT-A. To test compound efficacy in rats, formulations and administration procedures were established to give therapeutic inhibitor concentrations in blood and urine. We found that intravenous administration of an indole thiazole or a γ-sultambenzosulfonamide at 20 mg/kg increased urine output by 3-5-fold and reduced urine osmolality by ∼2-fold compared to vehicle control rats, even under conditions of maximum antidiuresis produced by 1-deamino-8-D-arginine vasopressin (DDAVP). The diuresis was reversible and showed urea > salt excretion. The results provide proof of concept for the diuretic action of UT-A-selective inhibitors. UT-A inhibitors are first in their class salt-sparing diuretics with potential clinical indications in volume-overload edemas and high-vasopressin-associated hyponatremias.

  4. LSST telescope modeling overview

    Science.gov (United States)

    Sebag, J.; Andrew, J.; Angeli, G.; Araujo, C.; Barr, J.; Callahan, S.; Cho, M.; Claver, C.; Daruich, F.; Gressler, W.; Hileman, E.; Liang, M.; Muller, G.; Neill, D.; Schoening, W.; Warner, M.; Wiecha, O.; Xin, B.; Orden Martinez, Alfredo; Perezagua Aguado, Manuel; García Marchena, Luis; Ruiz de Argandoña, Ismael

    2016-08-01

    During this early stage of construction of the Large Synoptic Survey Telescope (LSST), modeling has become a crucial system engineering process to ensure that the final detailed design of all the sub-systems that compose the telescope meet requirements and interfaces. Modeling includes multiple tools and types of analyses that are performed to address specific technical issues. Three-dimensional (3D) Computeraided Design (CAD) modeling has become central for controlling interfaces between subsystems and identifying potential interferences. The LSST Telescope dynamic requirements are challenging because of the nature of the LSST survey which requires a high cadence of rapid slews and short settling times. The combination of finite element methods (FEM), coupled with control system dynamic analysis, provides a method to validate these specifications. An overview of these modeling activities is reported in this paper including specific cases that illustrate its impact.

  5. Telescopes and Techniques

    CERN Document Server

    Kitchin, C R

    2013-01-01

    Telescopes and Techniques has proved itself in its first two editions, having become probably one of the most widely used astronomy texts, both for amateur astronomers and astronomy and astrophysics undergraduates. Both earlier editions of the book were widely used for introductory practical astronomy courses in many universities. In this Third Edition the author guides the reader through the mathematics, physics and practical techniques needed to use today's telescopes (from the smaller models to the larger instruments installed in many colleges) and how to find objects in the sky. Most of the physics and engineering involved is described fully and requires little prior knowledge or experience. Both visual and electronic imaging techniques are covered, together with an introduction to how data (measurements) should be processed and analyzed. A simple introduction to radio telescopes is also included. Brief coverage of the more advanced topics of photometry and spectroscopy are included, but mainly to enable ...

  6. Integrated Modeling of Telescopes

    CERN Document Server

    Andersen, Torben

    2011-01-01

    With increasingly complex and costly opto-mechanical systems, there is a growing need for reliable computer modeling and simulation. The field of integrated modeling, combining optics, mechanics, control engineering, and other disciplines, is the subject of this book. Although the book primarily focuses on ground-based optical telescopes, the techniques introduced are applicable also to other wavelengths and to other opto-mechanical applications on the ground or in space. Basic tools of integrated modeling are introduced together with concepts of ground-based telescopes. Modeling of optical systems, structures, wavefront control systems with emphasis on segmented mirror control, and active and adaptive optics are described together with a variety of noise sources; many examples are included in this book. Integrated Modeling of Telescopes is a text for physicists and engineers working in the field of opto-mechanical design and wavefront control, but it will also be valuable as a textbook for PhD students.

  7. Fibronectin promotes proplatelet formation in the human megakaryocytic cell line UT-7/TPO.

    Science.gov (United States)

    Kawaguchi, Tatsuya; Hatano, Ryo; Yamaguchi, Kyoji; Nawa, Katsuhiko; Hashimoto, Ryuji; Yokota, Hiroshi

    2012-01-01

    We investigated PPF (proplatelet formation) in the human megakaryocytic cell line UT-7/TPO in vitro and signal transduction pathways responsible for PPF. The megakaryocytic cell lines are useful for studying megakaryocyte biology, although PPF is induced only in the presence of phorbol ester. TPO (thrombopoietin) stimulates megakaryocyte proliferation and differentiation; however, no PPF occurred in the megakaryocytic cell lines, even after the addition of TPO. Therefore, factors other than TPO may play an important role in the process of PPF. As PPF occurs in the bone marrow in vivo, we noted extracellular matrix proteins and found that soluble FN (fibronectin) induced potent PPF in UT-7/TPO without phorbol ester. A Western blot analysis showed that the expression of integrins was not increased by FN treatment. Anti-β1 antibody and the RGD (arginine-glycine-aspartate) peptide inhibited FN-induced PPF. This result indicates that the signal originated from integrin β1, which is essential to inducing PPF in UT-7/TPO. Results of the experiments using several inhibitors suggest that activation of the MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase]-ERK and PI3K (phosphoinositide 3-kinase) pathways are necessary for PPF. The phosphorylation of ERK gradually increased for 2 h after the addition of soluble FN, which suggests that activation of ERK is essential for the initial induction of FN-induced PPF in UT-7/TPO. UT-7/TPO is a useful cell line that enables us to study the signals of PPF without effects of chemical compounds.

  8. The Discovery Channel Telescope

    Science.gov (United States)

    Millis, R. L.; Dunham, E. W.; Sebring, T. A.; Smith, B. W.; de Kock, M.; Wiecha, O.

    2004-11-01

    The Discovery Channel Telescope (DCT) is a 4.2-m telescope to be built at a new site near Happy Jack, Arizona. The DCT features a large prime focus mosaic CCD camera with a 2-degree-diameter field of view especially designed for surveys of KBOs, Centaurs, NEAs and other moving or time-variable targets. The telescope can be switched quickly to a Ritchey-Chretien configuration for optical/IR spectroscopy or near-IR imaging. This flexibility allows timely follow-up physical studies of high priority objects discovered in survey mode. The ULE (ultra-low-expansion) meniscus primary and secondary mirror blanks for the telescope are currently in fabrication by Corning Glass. Goodrich Aerospace, Vertex RSI, M3 Engineering and Technology Corp., and e2v Technologies have recently completed in-depth conceptual design studies of the optics, mount, enclosure, and mosaic focal plane, respectively. The results of these studies were subjected to a formal design review in July, 2004. Site testing at the 7760-ft altitude Happy Jack site began in 2001. Differential image motion observations from 117 nights since January 1, 2003 gave median seeing of 0.84 arcsec FWHM, and the average of the first quartile was 0.62 arcsec. The National Environmental Policy Act (NEPA) process for securing long-term access to this site on the Coconino National Forest is nearing completion and ground breaking is expected in the spring of 2005. The Discovery Channel Telescope is a project of the Lowell Observatory with major financial support from Discovery Communications, Inc. (DCI). DCI plans ongoing television programming featuring the construction of the telescope and the research ultimately undertaken with the DCT. An additional partner can be accommodated in the project. Interested parties should contact the lead author.

  9. Pointing the SOFIA Telescope

    CERN Document Server

    Gross, Michael A K; Moore, Elizabeth M

    2010-01-01

    SOFIA is an airborne, gyroscopically stabilized 2.5m infrared telescope, mounted to a spherical bearing. Unlike its predecessors, SOFIA will work in absolute coordinates, despite its continually changing position and attitude. In order to manage this, SOFIA must relate equatorial and telescope coordinates using a combination of avionics data and star identification, manage field rotation and track sky images. We describe the algorithms and systems required to acquire and maintain the equatorial reference frame, relate it to tracking imagers and the science instrument, set up the oscillating secondary mirror, and aggregate pointings into relocatable nods and dithers.

  10. Reflecting telescope optics

    CERN Document Server

    Wilson, Raymond N

    2004-01-01

    R.N. Wilson's two-volume treatise on reflecting telescope optics has become a classic in its own right. It is intended to give a complete treatment of the subject, addressing professionals in research and industry as well as students of astronomy and amateur astronomers. This first volume, Basic Design Theory and its Historical Development, is devoted to the theory of reflecting telescope optics and systematically recounts the historical progress. The author's approach is morphological, with strong emphasis on the historical development. The book is richly illustrated including spot-diagrams a

  11. New Vacuum Solar Telescope

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    With its pure aperture up to 985mm, the New Vacuum Solar Telescope of China (NVST) has become the world's biggest vacuum solar telescope. The main science task of NVST is the high-resolution observation of photosphere and chromosphere including their fine structure of magnetic field on the sun. The NVST was equipped with many new technologies and powerful instruments, such as an adaptive optical system, a polarization analyzer, two vertical spectrographs, a high-resolution image system and a very narrow Ha filter (0.125A).

  12. Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.

    Science.gov (United States)

    Wong, Vanessa K; Pickard, Derek J; Barquist, Lars; Sivaraman, Karthikeyan; Page, Andrew J; Hart, Peter J; Arends, Mark J; Holt, Kathryn E; Kane, Leanne; Mottram, Lynda F; Ellison, Louise; Bautista, Ruben; McGee, Chris J; Kay, Sally J; Wileman, Thomas M; Kenney, Linda J; MacLennan, Calman A; Kingsley, Robert A; Dougan, Gordon

    2013-01-01

    Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in the putative two-component regulatory system yehUT. Consequently we evaluated the function of yehUT in S. Typhi BRD948 and S. Typhimurium ST4/74. Transcriptome analysis identified the cstA gene, encoding a carbon starvation protein as the predominantly yehUT regulated gene in both these serovars. Deletion of yehUT had no detectable effect on the ability of these mutant Salmonella to invade cultured epithelial cells (S. Typhi and S. Typhimurium) or induce colitis in a murine model (S. Typhimurium only). Growth, metabolic and antimicrobial susceptibility tests identified no obvious influences of yehUT on these phenotypes.

  13. The Cepheid distance to NGC 5236 (M83) with the ESO Very Large Telescope

    NARCIS (Netherlands)

    Thim, F; Tammann, GA; Saha, A; Dolphin, A; Sandage, A; Tolstoy, E; Labhardt, L

    2003-01-01

    Cepheids have been observed in NGC 5236 (M83) using the Antu (Unit Telescope 1) 8.2 m telescope of the ESO Very Large Telescope with the Focal Reducer/Low Dispersion Spectrograph 1. Repeated imaging observations have been made between 2000 January and 2001 July. Images were obtained in 34 epochs in

  14. MROI Array telescopes: the relocatable enclosure domes

    Science.gov (United States)

    Marchiori, G.; Busatta, A.; Payne, I.

    2016-07-01

    The MROI - Magdalena Ridge Interferometer is a project which comprises an array of up to 10 1.4m diameter mirror telescopes arranged in a "Y" configuration. Each of these telescopes will be housed inside a Unit Telescope Enclosure (UTE) which are relocatable onto any of 28 stations. EIE GROUP Srl, Venice - Italy, was awarded the contract for the design, the construction and the erection on site of the MROI by the New Mexico Institute of Mining and Technology. The close-pack array of the MROI - including all 10 telescopes, several of which are at a relative distance of less than 8m center to center from each other - necessitated an original design for the Unit Telescope Enclosure (UTE). This innovative design enclosure incorporates a unique dome/observing aperture system to be able to operate in the harsh environmental conditions encountered at an altitude of 10,460ft (3,188m). The main characteristics of this Relocatable Enclosure Dome are: a Light insulated Steel Structure with a dome made of composites materials (e.g. glass/carbon fibers, sandwich panels etc.), an aperture motorized system for observation, a series of louvers for ventilation, a series of electrical and plants installations and relevant auxiliary equipment. The first Enclosure Dome is now under construction and the completion of the mounting on site id envisaged by the end of 2016. The relocation system utilizes a modified reachstacker (a transporter used to handle freight containers) capable of maneuvering between and around the enclosures, capable of lifting the combined weight of the enclosure with the telescope (30tons), with minimal impacts due to vibrations.

  15. THE LARGE MILLIMETER TELESCOPE

    Directory of Open Access Journals (Sweden)

    D. H. Hughes

    2009-01-01

    Full Text Available This paper, presented on behalf of the Large Millimeter Telescope (LMT project team, describes the status and near-term plans for the telescope and its initial instrumentation. The LMT is a bi-national collaboration between M xico and the USA, led by the Instituto Nacional de Astrof sica, ptica y Electr nica (INAOE and the University of Massachusetts at Amherst, to construct, commission and operate a 50 m diameter millimeterwave radio telescope. Construction activities are nearly complete at the LMT site, at an altitude of 4600 m on the summit of Sierra Negra, an extinct volcano in the Mexican state of Puebla. Full movement of the telescope, under computer control in both azimuth and elevation, has been achieved. First-light at centimeter wavelengths on astronomical sources was obtained in November 2006. Installation of precision surface segments for millimeter-wave operation is underway, with the inner 32 m diameter of the surface now complete and ready to be used to obtain rst-light at millimeter wavelengths in 2008. Installation of the remainder of the re ector will continue during the next year and be completed in 2009 for nal commissioning of the antenna. The full LMT antenna, out ted with its initial complement of scienti c instruments, will be a world-leading scienti c research facility for millimeter-wave astronomy.

  16. A Simple "Tubeless" Telescope

    Science.gov (United States)

    Straulino, S.; Bonechi, L.

    2010-01-01

    Two lenses make it possible to create a simple telescope with quite large magnification. The set-up is very simple and can be reproduced in schools, provided the laboratory has a range of lenses with different focal lengths. In this article, the authors adopt the Keplerian configuration, which is composed of two converging lenses. This instrument,…

  17. Exploring Galileo's Telescope

    Science.gov (United States)

    Straulino, Samuele; Terzuoli, Alessandra

    2010-01-01

    In the first months of 2009, the International Year of Astronomy, the authors developed an educational project for middle-level students connected with the first astronomical discoveries that Galileo Galilei (1564-1642) made 400 years ago. The project included the construction of a basic telescope and the observation of the Moon. The project, if…

  18. NRAO Green Bank Telescope (GBT)

    Data.gov (United States)

    Federal Laboratory Consortium — The largest fully steerable telescope in the world - the Robert C. Byrd Green Bank Telescope, began observations in Green Bank, West Virginia in 2000and is a wonder...

  19. Optical Space Telescope Assembly Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Optical Space Telescope Assembly (OSTA) task is to demonstrate the technology readiness of assembling large space telescopes on orbit in 2015. This task is an...

  20. Progress in Space Solar Telescope

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this paper we will summarize the progress in the development of the Chinese Space Solar Telescope (SST) during the past few years. The main scientific objective of SST is to observe the fundamental structure of solar magnetic field with its 1-m optical telescope. The success of 1-m Swedish Solar Telescope and Hinode underscores the importance of this 1-m space telescope. In addition, some key technical problems have been solved.

  1. Uzaybimer Radio Telescope Control System

    Science.gov (United States)

    Balbay, R.; Öz, G. K.; Arslan, Ö.; Özeren, F. F.; Küçük, İ.

    2016-12-01

    A 13 meters former NATO radar is being converted into a radio telescope. The radio telescope is controlled by a system which has been developed at UZAYBİMER. The Telescope Control System(TCS) has been designed using modern industrial systems. TCS has been developed in LabView platform in which works Windows embedded OS. The position feedback used on radio telescopes is an industrial EtherCAT standard. ASCOM library is used for astronomical calculations.

  2. Welfare Effects of Tax and Price Changes and the CES-UT Utility Function

    DEFF Research Database (Denmark)

    Munk, Knud Jørgen

    Dixit's 1975 paper "Welfare Effects of Tax and Price Changes" constitutes a seminal contribution to the theory of tax reform within a second-best general equilibrium framework. The present paper clarifies ambiguities with respect to normalisation which has led to misinterpretation of some of Dixit...... this insight cannot be articulated. This paper proposes as an alternative a parameterised utility function with explicit representation of the use of time, the CES-UT, which allows a flexible representation of the relationship between consumption and leisure. It also demonstrates how standard compensated price...... elasticities can be derived from the parameters of the CES-UT and how it may be used for applied tax reform analysis...

  3. Proceedings of the 15th Annual UT-KBRIN Bioinformatics Summit 2016

    OpenAIRE

    Rouchka, Eric C.; Chariker, Julia H; Harrison, Benjamin J; Cao, Xueyuan; Pounds, Stanley; Raimondi, Susana; Downing, James; Ribeiro, Raul; Rubnitz, Jeffery; Lamba, Jatinder; Daigle, Bernie J.; Johnson, Nicholas; Gehrlich, Stephanie; Burgess, Deborah; John C Carmen

    2016-01-01

    Table of contents I1 Proceedings of the Fifteenth Annual UT- KBRIN Bioinformatics Summit 2016 Eric C. Rouchka, Julia H. Chariker, Benjamin J. Harrison, Juw Won Park P1 CC-PROMISE: Projection onto the Most Interesting Statistical Evidence (PROMISE) with Canonical Correlation to integrate gene expression and methylation data with multiple pharmacologic and clinical endpoints Xueyuan Cao, Stanley Pounds, Susana Raimondi, James Downing, Raul Ribeiro, Jeffery Rubnitz, Jatinder Lamba P2 Integration...

  4. POLITISCHER ISLAMISMUS UND DIE INTERNATIONALE POLITIK. DIE MOBILISIERENDE RHETORIK VON HIZB UT-TAHRIR

    Directory of Open Access Journals (Sweden)

    Ali Hedayat

    2015-03-01

    Full Text Available Der folgende Beitrag befasst sich mit der Erfassung islamistischer Radikalisierungsprozesse durch die Rhetorik. Der Protest politischer Islamisten wird anhand von Indikatoren wie Protestaktionen oder einer konfrontativen Rhetorik zur Mobilisierung politischer Gewalt und terroristischer Anschläge gemessen. Das Ziel dieses Beitrages ist, das Gefahrenpotenzial durch politische Islamisten am Beispiel der mobilisierenden Rhetorik der islamistischen Hizb ut-Tahrir (HuT besser einzuschätzen.

  5. Comparing NEO Search Telescopes

    CERN Document Server

    Myhrvold, Nathan

    2015-01-01

    Multiple terrestrial and space-based telescopes have been proposed for detecting and tracking near-Earth objects (NEOs). Detailed simulations of the search performance of these systems have used complex computer codes that are not widely available, which hinders accurate cross- comparison of the proposals and obscures whether they have consistent assumptions. Moreover, some proposed instruments would survey infrared (IR) bands, whereas others would operate in the visible band, and differences among asteroid thermal and visible light models used in the simulations further complicate like-to-like comparisons. I use simple physical principles to estimate basic performance metrics for the ground-based Large Synoptic Survey Telescope and three space-based instruments - Sentinel, NEOCam, and a Cubesat constellation. The performance is measured against two different NEO distributions, the Bottke et al. distribution of general NEOs, and the Veres et al. distribution of earth impacting NEO. The results of the comparis...

  6. The ANTARES Neutrino Telescope

    CERN Document Server

    Perrina, Chiara

    2015-01-01

    At about 40 km off the coast of Toulon (France), anchored at 2475 m deep in the Mediterranean Sea, there is ANTARES: the first undersea neutrino telescope and the only one currently operating. The detector consists of 885 photomultiplier tubes arranged into 12 strings of 450-metres high, with the aim to detect the Cherenkov light induced by the charged superluminal interaction products of neutrinos. Its main scientific target is the search for high-energy (TeV and beyond) neutrinos from cosmic accelerators, as predicted by hadronic interaction models, and the measurement of the cosmic neutrino diffuse flux, focusing in particular on events coming from below the horizon (up-going events) in order to significantly reduce the atmospheric muons background. Thanks to the development of a strategy for the identification of neutrinos coming from above the horizon (down-going events) the field of view of the telescope will be extended.

  7. Telescopic limiting magnitudes

    Science.gov (United States)

    Schaefer, Bradley E.

    1990-01-01

    The prediction of the magnitude of the faintest star visible through a telescope by a visual observer is a difficult problem in physiology. Many prediction formulas have been advanced over the years, but most do not even consider the magnification used. Here, the prediction algorithm problem is attacked with two complimentary approaches: (1) First, a theoretical algorithm was developed based on physiological data for the sensitivity of the eye. This algorithm also accounts for the transmission of the atmosphere and the telescope, the brightness of the sky, the color of the star, the age of the observer, the aperture, and the magnification. (2) Second, 314 observed values for the limiting magnitude were collected as a test of the formula. It is found that the formula does accurately predict the average observed limiting magnitudes under all conditions.

  8. Everyday Radio Telescope

    CERN Document Server

    Mandal, Pranshu; Kumar, Pratik; Yelikar, Anjali; Soni, Kanchan; T, Vineeth Krishna

    2016-01-01

    We have developed an affordable, portable college level radio telescope for amateur radio astronomy which can be used to provide hands-on experience with the fundamentals of a radio telescope and an insight into the realm of radio astronomy. With our set-up one can measure brightness temperature and flux of the Sun at 11.2 GHz and calculate the beam width of the antenna. The set-up uses commercially available satellite television receiving system and parabolic dish antenna. We report the detection of point sources like Saturn and extended sources like the galactic arm of the Milky way. We have also developed python pipeline, which are available for free download, for data acquisition and visualization.

  9. Origins Space Telescope

    Science.gov (United States)

    Cooray, Asantha R.; Origins Space Telescope Study Team

    2017-01-01

    The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, a study in development by NASA in preparation for the 2020 Astronomy and Astrophysics Decadal Survey. Origins is planned to be a large aperture, actively-cooled telescope covering a wide span of the mid- to far-infrared spectrum. Its spectrographs will enable 3D surveys of the sky that will discover and characterize the most distant galaxies, Milky-Way, exoplanets, and the outer reaches of our Solar system. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. The Science and Technology Definition Team (STDT) would like to hear your science needs and ideas for this mission. The team can be contacted at firsurveyor_info@lists.ipac.caltech.edu. I will summarize the OST STDT, mission design and instruments, key science drivers, and the study plan over the next two years.

  10. Numerical modeling of the equatorial electrojet UT-variation on the basis of the model GSM TIP

    Directory of Open Access Journals (Sweden)

    M. V. Klimenko

    2007-06-01

    Full Text Available In the presented work the results of numerical modeling of the UT-variation of the equatorial electrojet, executed on the basis of the model GSM TIP are presented, taking into account the dynamo electric fields generated by thermospheric winds in a current-carrying layer of the ionosphere at heights 80–175 km above a surface of the Earth. To the Global Self-consistent Model of the Thermosphere, Ionosphere and Protonosphere (GSM TIP, developed in WD IZMIRAN, a new block for the calculation of electric fields in the ionosphere has been added. In this block the solution of the three-dimensional equation describing the conservation law of the full current in the Earth's ionosphere is reduced to the solution of the two-dimensional equation by integration along geomagnetic field lines. Calculations of parameters of the near-Earth space plasmas have been executed for quiet equinoctial conditions on 22 March 1987 during the minimum of solar activity.

    It has been shown, that there is a distinct semidiurnal harmonic in the diurnal behavior of the linear density of the equatorial electrojet with maxima at 23:00 UT and 15:00 UT, as well as with minima at 06:00 UT and 20:00 UT. The greatest and smallest values of the peak intensity of the equatorial electrojet with respect to the diurnal behavior can differ by a factor of two. The longitudinal extent of the area of the equatorial electrojet does hardly show any UT-variation, but the greatest longitudinal extent is at 06 UT. With the growth of the peak intensity of the equatorial electrojet its latitudinal extent also increases (on ~5–10° a little. At the same time the equatorial electrojet in the maxima of intensity has approximately an identical width, whereas in the minima the electrojet is narrow in the morning and wide in the afternoon.

    As for the surface density of the equatorial electrojet, its UT-variation is much weaker and equals ~1–3 A/km2 and the peak

  11. Array UT and ECT Systems for Inspection of Nuclear Power Components

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Chan Hee; Lee, Tae Hun; Yoo, Hyun Ju [Korea Hydro and Nuclear Power Co. Ltd. CRI, Daejeon (Korea, Republic of)

    2015-10-15

    The ultrasonic testing is mainly used for the inspection of welds in piping and nozzle for many components. The eddy current testing is widely used for the inspection of heat exchanger tubing like steam generator tubing. Technologies for these methods have been advanced for the reduction of inspection time and the increase of inspection reliability. Data cannot be stored during the inspection using a manual ultrasonic testing system. In steam generator tubing inspection, the rotating probe technology is regarded as the time-consuming method. Therefore, the array UT and ECT systems have been developed in order to overcome these barriers of conventional methods. The Korea Hydro and Nuclear Power Co., Ltd. (KHNP) is developing the phased array UT and multi-array ECT systems for the inspection of nuclear power components. Details of these systems are described in this paper. The phased array UT and the multi-array ECT systems are being developed. These systems produced good results from the calibration standards.

  12. The Cherenkov Telescope Array

    Science.gov (United States)

    Connaughton, Valerie

    2014-03-01

    The Cherenkov Telescope Array (CTA) is a large collaborative effort dedicated to the design and operation of the next-generation ground-based very high-energy gamma-ray observatory. CTA will improve by about one order of magnitude the sensitivity with respect to the current major arrays (VERITAS, H.E.S.S., and MAGIC) in the core energy range of 100 GeV to 10 TeV, and will extend the viability of the imaging atmospheric Cherenkov technique (IACT) down to tens of GeV and above 100 TeV. In order to achieve such improved performance at both a northern and southern CTA site, four 23m diameter Large Size Telescopes (LST) optimized for low energy gamma rays will be deployed close to the centre of the array. A larger number of Medium Size Telescopes (MST) will be optimized for the core IACT energy range. The southern site will include 25 12m single-mirror MSTs and a US contribution of up to 24 novel dual-mirror design Schwarzschild-Couder (SC) type MSTs with a primary mirror of 9.5m diameter, and will also include an array of Small Size Telescopes (SST) to observe the highest-energy gamma rays from galactic sources. The SSTs can be smaller and more widely separated because more energetic gamma rays produce a larger Cherenkov light pool with many photons. The SSTs achieve a large collection area by covering a wide (10 sq km) footprint on the ground. The CTA project is finishing its preparatory phase, and the pre-production phase will start this year. I will review the status and the expected performance of CTA as well as the main scientific goals for the observatory.

  13. [Galileo and his telescope].

    Science.gov (United States)

    Strebel, Christoph

    2006-01-01

    Galileo's publication of observations made with his newly reinvented telescope provoked a fierce debate. In April 1610 Martinus Horky, a young Bohemian astronomer, had an opportunity to make his own observations with Galileo's telescope in the presence of Antonio Magini and other astronomers. Horky and the other witnesses denied the adequacy of Galileo's telescope and therefore the bona fides of his discoveries. Kepler conjectured Horky as well as all his witnesses to be myopic. But Kepler's objection could not stop the publication of Horky's Peregrinatio contra nuncium sidereum (Modena, 1610), the first printed refutation of Galileo's Sidereus nuncius. In his treatise, Horky adresses four questions: 1) Do the four newly observed heavenly bodies actually exist? Horky denies their existence on various grounds: a) God, as every astronomer teaches, has created only seven moveable heavenly bodies and astronomical knowledge originates in God, too. b) Heavenly bodies are either stars or planets. Galileo's moveable heavenly bodies fit into neither category. c) If they do exist, why have they not already been observed by other scholars? Horky concludes that there are no such heavenly bodies. 2) What are these phenomena? They are purely artefactual, and produced by Galileo's telescope. 3) How are they like? Galileo's "stars" are so small as to be almost invisible. Galileo claims that he has measured their distances from each other. This however is impossible due to their diminutive size and other observational problems. Hence, Galileo's claim is a further proof that he is a fraud. 4) Why are they? For Galileo they are a chance to earn money but for astronomers like Horky they are a reason to offer thanks and honour to God. Horky's treatise was favourably received by the enemies of Galileo. But Kepler's critique was devastating. After calling on Kepler in Prague, Horky had to revoke the contents of his book.

  14. Fast Fourier transform telescope

    Science.gov (United States)

    Tegmark, Max; Zaldarriaga, Matias

    2009-04-01

    We propose an all-digital telescope for 21 cm tomography, which combines key advantages of both single dishes and interferometers. The electric field is digitized by antennas on a rectangular grid, after which a series of fast Fourier transforms recovers simultaneous multifrequency images of up to half the sky. Thanks to Moore’s law, the bandwidth up to which this is feasible has now reached about 1 GHz, and will likely continue doubling every couple of years. The main advantages over a single dish telescope are cost and orders of magnitude larger field-of-view, translating into dramatically better sensitivity for large-area surveys. The key advantages over traditional interferometers are cost (the correlator computational cost for an N-element array scales as Nlog⁡2N rather than N2) and a compact synthesized beam. We argue that 21 cm tomography could be an ideal first application of a very large fast Fourier transform telescope, which would provide both massive sensitivity improvements per dollar and mitigate the off-beam point source foreground problem with its clean beam. Another potentially interesting application is cosmic microwave background polarization.

  15. Hubble Space Telescope satellite

    Science.gov (United States)

    Mitchell, R. E.

    1985-01-01

    The Hubble Space Telescope, named for the American astronomer Edwin Powell Hubble, will be the largest and most powerful astronomical instrument ever orbited. Placed above the obscuring effects of the earth's atmosphere in a 600-km orbit, this remotely-controlled, free-flying satellite observatory will expand the terrestrial-equivalent resolution of the universe by a factor of seven, or a volumetric factor of 350. This telescope has a 2.4-m primary mirror and can accommodate five scientific instruments (cameras, spectrographs and photometers). The optics are suitable for a spectral range from 1100 angstrom to 1 mm wavelength. With a projected service life of fifteen years, the spacecraft can be serviced on-orbit for replacement of degraded systems, to insert advanced scientific instruments, and to reboost the telescope from decayed altitudes. The anticipated image quality will be a result of extremely precise lambda/20 optics, stringent cleanliness, and very stable pointing: jitter will be held to less than 0.01 arcsecond for indefinite observation periods, consistent with instrument apertures as small as 0.1 arcsecond.

  16. SOAR Telescope Progress Report

    Science.gov (United States)

    Sebring, T.; Cecil, G.; Krabbendam, V.

    1999-12-01

    The 4.3m SOAR telescope is fully funded and under construction. A partnership between the country of Brazil, NOAO, Michigan State University, and the University of North Carolina at Chapel Hill, SOAR is being designed for high-quality imaging and imaging spectroscopy in the optical and near-IR over a field of view up to 12' diameter. US astronomers outside MSU and UNC will access 30% of the observing time through the standard NOAO TAC process. The telescope is being designed to support remote and synoptic observations. First light is scheduled for July 2002 at Cerro Pachon in Chile, a site with median seeing of 2/3" at 500 nm. The telescope will be operated by CTIO. Corning Inc. has fused the mirror blanks from boules of ULE glass. RSI in Richardson, Texas and Raytheon Optical Systems Inc. in Danbury, Conn. are designing and will fabricate the mount and active optics systems, respectively. The mount supports an instrument payload in excess of 5000 kg, at 2 Nasmyth locations and 3 bent Cass. ports. The mount and facility building have space for a laser to generate an artificial AO guide star. LabVIEW running under the Linux OS on compactPCI hardware has been adopted to control all telescope, detector, and instrument systems. The primary mirror is 10 cm thick and will be mounted on 120 electro-mechanical actuators to maintain its ideal optical figure at all elevations. The position of the light-weighted secondary mirror is adjusted to maintain collimation through use of a Shack-Hartmann wavefront sensor. The tertiary mirror feeds instruments and also jitters at up to 50 Hz to compensate for telescope shake and atmosphere wavefront tilt. The dome is a steel framework, with fiberglass panels. Air in the observing volume will be exchanged with that outside every few minutes by using large fans under computer control. All systems will be assembled and checked at the manufacturer's facility, then shipped to Chile. A short integration period is planned, and limited science

  17. Reduced urea flux across the blood-testis barrier and early maturation in the male reproductive system in UT-B-null mice.

    Science.gov (United States)

    Guo, Lirong; Zhao, Dan; Song, Yuanlin; Meng, Yan; Zhao, Huashan; Zhao, Xuejian; Yang, Baoxue

    2007-07-01

    A urea-selective urine-concentrating defect was found in transgenic mice deficient in urea transporter (UT)-B. To determine the role of facilitated urea transport in extrarenal organs expressing UT-B, we studied the kinetics of [(14)C]urea distribution in UT-B-null mice versus wild-type mice. After renal blood flow was disrupted, [(14)C]urea distribution was selectively reduced in testis in UT-B-null mice. Under basal conditions, total testis urea content was 335.4 +/- 43.8 microg in UT-B-null mice versus 196.3 +/- 18.2 microg in wild-type mice (P UT-B-null mice (6.6 +/- 0.8 mg/g body wt) was significantly greater than in wild-type mice (4.2 +/- 0.8 mg/g body wt). Elongated spermatids were observed earlier in UT-B-null mice compared with wild type mice on day 24 versus day 32, respectively. First breeding ages in UT-B knockout males (48 +/- 3 days) were also significantly earlier than that in wild-type males (56 +/- 2 days). In competing mating tests with wild-type males and UT-B-null males, all pups carried UT-B-targeted genes, which indicates that all pups were produced from breeding of UT-B-null males. Experiments of the expression of follicle-stimulating hormone receptor (FSHR) and androgen binding protein (ABP) indicated that the development of Sertoli cells was also earlier in UT-B-null mice than that in wild-type mice. These results suggest that UT-B plays an important role in eliminating urea produced by Sertoli cells and that UT-B deletion causes both urea accumulation in the testis and early maturation of the male reproductive system. The UT-B knockout mouse may be a useful experimental model to define the molecular mechanisms of early puberty.

  18. ALMA telescope reaches new heights

    Science.gov (United States)

    2009-09-01

    the electromagnetic spectrum. Light at these wavelengths comes from some of the coldest, but also from some of the most distant objects in the cosmos. These include cold clouds of gas and dust where new stars are being born and remote galaxies towards the edge of the observable universe. The Universe is relatively unexplored at submillimetre wavelengths, as the telescopes need extremely dry atmospheric conditions, such as those at Chajnantor, and advanced detector technology. More information The Atacama Large Millimeter/submillimeter Array (ALMA), an international astronomy facility, is a partnership of Europe, North America and East Asia in cooperation with the Republic of Chile. ESO is the European partner in ALMA. ALMA, the largest astronomical project in existence, is a revolutionary telescope, comprising an array of 66 giant 12-metre and 7-metre diameter antennas observing at millimetre and submillimetre wavelengths. ALMA will start scientific observations in 2011. ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a

  19. Flasher and muon-based calibration of the GCT telescopes proposed for the Cherenkov Telescope Array

    CERN Document Server

    Brown, Anthony M; Chadwick, Paula M; Daniel, Michael; White, Richard

    2015-01-01

    The GCT is a dual-mirror Small-Sized-Telescope prototype proposed for the Cherenkov Telescope Array. Calibration of the GCT's camera is primarily achieved with LED-based flasher units capable of producing $\\sim4$ ns FWHM pulses of 400 nm light across a large dynamic range, from 0.1 up to 1000 photoelectrons. The flasher units are housed in the four corners of the camera's focal plane and illuminate it via reflection from the secondary mirror. These flasher units are adaptable to allow several calibration scenarios to be accomplished: camera flat-fielding, linearity measurements (up to and past saturation), and gain estimates from both single pe measurements and from the photon statistics at various high illumination levels. In these proceedings, the performance of the GCT flashers is described, together with ongoing simulation work to quantify the efficiency of using muon rings as an end-to-end calibration for the optical throughput of the GCT.

  20. Archive of Geosample Data and Information from the University of Texas at Austin (UT) Institute of Geophysics

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Metadata describing piston cores curated by Institute of Geophysics of the University of Texas at Austin (UT) collected from 1976 to 1978 were coded and contributed...

  1. 77 FR 47090 - Notice of Realty Action; Proposed Competitive Sale of Public Lands in Washington County, UT

    Science.gov (United States)

    2012-08-07

    ... Washington County, UT AGENCY: Bureau of Land Management, Interior. ] ACTION: Notice. SUMMARY: The Bureau of... publication of this notice. Electronic mail (email) will also be accepted and should be sent to...

  2. 78 FR 55093 - Call for Nominations to the Grand Staircase-Escalante National Monument Advisory Committee, UT

    Science.gov (United States)

    2013-09-09

    ... Advisory Committee, UT AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: The purpose of... no later than October 9, 2013. ADDRESSES: GSENM Headquarters Office, 669 South Highway 89A, Kanab,...

  3. Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells.

    Science.gov (United States)

    Klein, Janet D; Blount, Mitsi A; Fröhlich, Otto; Denson, Chad E; Tan, Xiaoxiao; Sim, Jae H; Martin, Christopher F; Sands, Jeff M

    2010-04-01

    Vasopressin is the primary hormone regulating urine-concentrating ability. Vasopressin phosphorylates the UT-A1 urea transporter in rat inner medullary collecting ducts (IMCDs). To assess the effect of UT-A1 phosphorylation at S486, we developed a phospho-specific antibody to S486-UT-A1 using an 11 amino acid peptide antigen starting from amino acid 482 that bracketed S486 in roughly the center of the sequence. We also developed two stably transfected mIMCD3 cell lines: one expressing wild-type UT-A1 and one expressing a mutated form of UT-A1, S486A/S499A, that is unresponsive to protein kinase A. Forskolin stimulates urea flux in the wild-type UT-A1-mIMCD3 cells but not in the S486A/S499A-UT-A1-mIMCD3 cells. The phospho-S486-UT-A1 antibody identified UT-A1 protein in the wild-type UT-A1-mIMCD3 cells but not in the S486A/S499A-UT-A1-mIMCD3 cells. In rat IMCDs, forskolin increased the abundance of phospho-S486-UT-A1 (measured using the phospho-S486 antibody) and of total UT-A1 phosphorylation (measured by (32)P incorporation). Forskolin also increased the plasma membrane accumulation of phospho-S486-UT-A1 in rat IMCD suspensions, as measured by biotinylation. In rats treated with vasopressin in vivo, the majority of the phospho-S486-UT-A1 appears in the apical plasma membrane. In summary, we developed stably transfected mIMCD3 cell lines expressing UT-A1 and an S486-UT-A1 phospho-specific antibody. We confirmed that vasopressin increases UT-A1 accumulation in the apical plasma membrane and showed that vasopressin phosphorylates UT-A1 at S486 in rat IMCDs and that the S486-phospho-UT-A1 form is primarily detected in the apical plasma membrane.

  4. The Planck Telescope reflectors

    Science.gov (United States)

    Stute, Thomas

    2004-09-01

    The mechanical division of EADS-Astrium GmbH, Friedrichshafen is currently engaged with the development, manufacturing and testing of the advanced dimensionally stable composite reflectors for the ESA satellite borne telescope Planck. The objective of the ESA mission Planck is to analyse the first light that filled the universe, the cosmic microwave background radiation. Under contract of the Danish Space Research Institute and ESA EADS-Astrium GmbH is developing the all CFRP primary and secondary reflectors for the 1.5-metre telescope which is the main instrument of the Planck satellite. The operational frequency ranges from to 25 GHz to 1000 GHz. The demanding high contour accuracy and surface roughness requirements are met. The design provides the extreme dimensional stability required by the cryogenic operational environment at around 40 K. The elliptical off-axis reflectors display a classical lightweight sandwich design with CFRP core and facesheets. Isostatic mounts provide the interfaces to the telescope structure. Protected VDA provides the reflecting surface. The manufacturing is performed at the Friedrichshafen premises of EADS-Space Transportation GmbH, the former Dornier composite workshops. Advanced manufacturing technologies like true angle lay-up by CNC fibre placement and filament winding are utilized. The protected coating is applied at the CAHA facilities at the Calar Alto Observatory, Spain. The exhaustive environmental testing is performed at the facilities of IABG, Munich (mechanical testing) and for the cryo-optical tests at CSL Liege. The project is in advanced state with both Qualification Models being under environmental testing. The flight models will be delivered in 2004. The paper gives an overview over the requirements and the main structural features how these requirements are met. Special production aspects and available test results are reported.

  5. Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways.

    Science.gov (United States)

    Huang, Haidong; Feng, Xiuyan; Zhuang, Jieqiu; Fröhlich, Otto; Klein, Janet D; Cai, Hui; Sands, Jeff M; Chen, Guangping

    2010-12-01

    Dynamin is a large GTPase involved in several distinct modes of cell endocytosis. In this study, we examined the possible role of dynamin in UT-A1 internalization. The direct relationship of UT-A1 and dynamin was identified by coimmunoprecipitation. UT-A1 has cytosolic NH(2) and COOH termini and a large intracellular loop. Dynamin specifically binds to the intracellular loop of UT-A1, but not the NH(2) and COOH termini. In cell surface biotinylation experiments, coexpression of dynamin and UT-A1 in HEK293 cells resulted in a decrease of UT-A1 cell surface expression. Conversely, cells expressing dynamin mutant K44A, which is deficient in GTP binding, showed an increased accumulation of UT-A1 protein on the cell surface. Cell plasma membrane lipid raft fractionation experiments revealed that blocking endocytosis with dynamin K44A causes UT-A1 protein accumulation in both the lipid raft and nonlipid raft pools, suggesting that both caveolae- and clathrin-mediated mechanisms may be involved in the internalization of UT-A1. This was further supported by 1) small interfering RNA to knock down either caveolin-1 or μ2 reduced UT-A1 internalization in HEK293 cells and 2) inhibition of either the caveolae pathway by methyl-β-cyclodextrin or the clathrin pathway by concanavalin A caused UT-A1 cell membrane accumulation. Functionally, overexpression of dynamin, caveolin, or μ2 decreased UT-A1 urea transport activity and decreased UT-A1 cell surface expression. We conclude that UT-A1 endocytosis is dynamin-dependent and mediated by both caveolae- and clathrin-coated pit pathways.

  6. The Cherenkov Telescope Array

    CERN Document Server

    Bigongiari, Ciro

    2016-01-01

    The Cherenkov Telescope Array (CTA) is planned to be the next generation ground based observatory for very high energy (VHE) gamma-ray astronomy. Gamma-rays provide a powerful insight into the non-thermal universe and hopefully a unique probe for new physics. Imaging Cherenkov telescopes have already discovered more than 170 VHE gamma-ray emitters providing plentiful of valuable data and clearly demonstrating the power of this technique. In spite of the impressive results there are indications that the known sources represent only the tip of the iceberg. A major step in sensitivity is needed to increase the number of detected sources, observe short time-scale variability and improve morphological studies of extended sources. An extended energy coverage is advisable to observe far-away extragalactic objects and improve spectral analysis. CTA aims to increase the sensitivity by an order of magnitude compared to current facilities, to extend the accessible gamma-ray energies from a few tens of GeV to a hundred o...

  7. Large Size Telescope Report

    CERN Document Server

    Mazin, D; Teshima, M

    2016-01-01

    The Cherenkov Telescope Array (CTA) observatory will be deployed over two sites in the two hemispheres. Both sites will be equipped with four Large Size Telescopes (LSTs), which are crucial to achieve the science goals of CTA in the 20-200 GeV energy range. Each LST is equipped with a primary tessellated mirror dish of 23 m diameter, supported by a structure made mainly of carbon fibre reinforced plastic tubes and aluminum joints. This solution guarantees light weight (around 100 tons), essential for fast repositioning to any position in the sky in <20 seconds. The camera is composed of 1855 photomultiplier tubes and embeds the control, readout and trigger electronics. The detailed design is now complete and production of the first LST, which will serve as a prototype for the remaining seven, is ongoing. The installation of the first LST at the Roque de los Muchachos Observatory on the Canary island of La Palma (Spain) started in July 2016. In this paper we will outline the technical solutions adopted to f...

  8. Magellan Telescopes operations 2008

    Science.gov (United States)

    Osip, David J.; Phillips, Mark M.; Palunas, Povilas; Perez, Frank; Leroy, M.

    2008-07-01

    The twin 6.5m Magellan Telescopes have been in routine operations at the Las Campanas Observatory in the Chilean Andes since 2001 and 2002 respectively. The telescopes are owned and operated by Carnegie for the benefit of the Magellan consortium members (Carnegie Institution of Washington, Harvard University, the University of Arizona, Massachusetts Institute of Technology, and the University of Michigan). This paper provides an up to date review of the scientific, technical, and administrative structure of the 'Magellan Model' for observatory operations. With a modest operations budget and a reasonably small staff, the observatory is operated in the "classical" mode, wherein the visiting observer is a key member of the operations team. Under this model, all instrumentation is supplied entirely by the consortium members and the various instrument teams continue to play a critical support role beyond initial deployment and commissioning activities. Here, we present a critical analysis of the Magellan operations model and suggest lessons learned and changes implemented as we continue to evolve an organizational structure that can efficiently deliver a high scientific return for the investment of the partners.

  9. Large size telescope report

    Science.gov (United States)

    Mazin, D.; Cortina, J.; Teshima, M.

    2017-01-01

    The Cherenkov Telescope Array (CTA) observatory will be deployed over two sites in the two hemispheres. Both sites will be equipped with four Large Size Telescopes (LSTs), which are crucial to achieve the science goals of CTA in the 20-200 GeV energy range. Each LST is equipped with a primary tessellated mirror dish of 23 m diameter, supported by a structure made mainly of carbon fibre reinforced plastic tubes and aluminum joints. This solution guarantees light weight (around 100 tons), essential for fast repositioning to any position in the sky in <20 seconds. The camera is composed of 1855 photomultiplier tubes and embeds the control, readout and trigger electronics. The detailed design is now complete and production of the first LST, which will serve as a prototype for the remaining seven, is ongoing. The installation of the first LST at the Roque de los Muchachos Observatory on the Canary island of La Palma (Spain) started in July 2016. In this paper we will outline the technical solutions adopted to fulfill the design requirements, present results of element prototyping and describe the installation and operation plans.

  10. Deep space telescopes

    CERN Document Server

    CERN. Geneva

    2006-01-01

    The short series of seminars will address results and aims of current and future space astrophysics as the cultural framework for the development of deep space telescopes. It will then present such new tools, as they are currently available to, or imagined by, the scientific community, in the context of the science plans of ESA and of all major world space agencies. Ground-based astronomy, in the 400 years since Galileo’s telescope, has given us a profound phenomenological comprehension of our Universe, but has traditionally been limited to the narrow band(s) to which our terrestrial atmosphere is transparent. Celestial objects, however, do not care about our limitations, and distribute most of the information about their physics throughout the complete electromagnetic spectrum. Such information is there for the taking, from millimiter wavelengths to gamma rays. Forty years astronomy from space, covering now most of the e.m. spectrum, have thus given us a better understanding of our physical Universe then t...

  11. Upgrade of the MAGIC telescopes

    CERN Document Server

    Mazin, Daniel; Garczarczyk, Markus; Giavitto, Gianluca; Sitarek, Julian

    2014-01-01

    The MAGIC telescopes are two Imaging Atmospheric Cherenkov Telescopes (IACTs) located on the Canary island of La Palma. With 17m diameter mirror dishes and ultra-fast electronics, they provide an energy threshold as low as 50 GeV for observations at low zenith angles. The first MAGIC telescope was taken in operation in 2004 whereas the second one joined in 2009. In 2011 we started a major upgrade program to improve and to unify the stereoscopic system of the two similar but at that time different telescopes. Here we report on the upgrade of the readout electronics and digital trigger of the two telescopes, the upgrade of the camera of the MAGIC I telescope as well as the commissioning of the system after this major upgrade.

  12. National Large Solar Telescope of Russia

    Science.gov (United States)

    Demidov, Mikhail

    One of the most important task of the modern solar physics is multi-wavelength observations of the small-scale structure of solar atmosphere on different heights, including chromosphere and corona. To do this the large-aperture telescopes are necessary. At present time there several challenging projects of the large (and even giant) solar telescopes in the world are in the process of construction or designing , the most known ones among them are 4-meter class telescopes ATST in USA and EST in Europe. Since 2013 the development of the new Large Solar Telescope (LST) with 3 meter diameter of the main mirror is started in Russia as a part (sub-project) of National Heliogeophysical Complex (NHGC) of the Russian Academy of Sciences. It should be located at the Sayan solar observatory on the altitude more then 2000 m. To avoid numerous problems of the off-axis optical telescopes (despite of the obvious some advantages of the off-axis configuration) and to meet to available financial budget, the classical on-axis Gregorian scheme on the alt-azimuth mount has been chosen. The scientific equipment of the LST-3 will include several narrow-band tunable filter devices and spectrographs for different wavelength bands, including infrared. The units are installed either at the Nasmyth focus or/and on the rotating coude platform. To minimize the instrumental polarization the polarization analyzer is located near diagonal mirror after M2 mirror. High order adaptive optics is used to achieve the diffraction limited performances. It is expected that after some modification of the optical configuration the LST-3 will operate as an approximately 1-m mirror coronograph in the near infrared spectral lines. Possibilities for stellar observations during night time are provided as well.

  13. Grid Integration of Robotic Telescopes

    CERN Document Server

    Breitling, F; Enke, H

    2008-01-01

    Robotic telescopes and grid technology have made significant progress in recent years. Both innovations offer important advantages over conventional technologies, particularly in combination with one another. Here, we introduce robotic telescopes used by the Astrophysical Institute Potsdam as ideal instruments for building a robotic telescope network. We also discuss the grid architecture and protocols facilitating the network integration that is being developed by the German AstroGrid-D project. Finally, we present three user interfaces employed for this purpose.

  14. Near Earth Object Survey Telescope

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The Near Earth Object Survey Telescope (NEOST), located at the Xuyi station of the Purple Mountain Observatory, is a telescope with the most powerful detection capacity, the highest efficiency and the best performance in the fields of near Earth object survey and optical imaging in China. NEOST is an 171.8 Schmidt type telescope with a 1.20 meter primary mirror and a 1.04 meter corrector,

  15. Internationality meets locality - ART IST KUKU NU UT festival in Tartu / Tanel Rander

    Index Scriptorium Estoniae

    Rander, Tanel, 1980-

    2012-01-01

    Kunstifestivalist ART IST KUKU NU UT. Näitusest "Möh? Fui! Öäk! Ossa! Vau! Eesti kaasaegse kunsti klassika" (06.09.-18.11.2012) Tartu Kunstimuuseumis. Festivali projektijuht Kaisa Eiche, kunstiline juht ja näituse kuraator Rael Artel. Näitusel osalesid Jaan Toomik, Raul Meel, Kai Kaljo, Johnson & Johnson, Anna-Stina Treumund ja Flo Kasearu. Chris Fitzpatrick'u kureeritud näitusest "Sõida tasa üle silla" (07.-30.09.2012) galeriis Noorus. Kuku Nunnu stipendiaadi Eike Epliku isikunäitusest "Tüdruk, kes kõike arnastas" (07.09.-28.10.2012) Y-galeriis

  16. Results of the 2013 UT modeling benchmark obtained with models implemented in CIVA

    Energy Technology Data Exchange (ETDEWEB)

    Toullelan, Gwénaël; Raillon, Raphaële; Chatillon, Sylvain [CEA, LIST, 91191Gif-sur-Yvette (France); Lonne, Sébastien [EXTENDE, Le Bergson, 15 Avenue Emile Baudot, 91300 MASSY (France)

    2014-02-18

    The 2013 Ultrasonic Testing (UT) modeling benchmark concerns direct echoes from side drilled holes (SDH), flat bottom holes (FBH) and corner echoes from backwall breaking artificial notches inspected with a matrix phased array probe. This communication presents the results obtained with the models implemented in the CIVA software: the pencilmodel is used to compute the field radiated by the probe, the Kirchhoff approximation is applied to predict the response of FBH and notches and the SOV (Separation Of Variables) model is used for the SDH responses. The comparison between simulated and experimental results are presented and discussed.

  17. Constrain the UT angle gamma by CP violation parameters in B0 -> pi+ pi-

    CERN Document Server

    Qin, Qin; Lü, Cai-Dian; Li, Ying

    2015-01-01

    We calculate the tree and penguin amplitudes in the $B^0\\to\\pi^+\\pi^-$ decay channel employing the perturbative QCD factorization approach. Using the amplitudes as input with the theoretical uncertainties sufficiently considered, we constrain the UT angle $\\gamma$ to $51^\\circ\\leq\\gamma\\leq64^\\circ$, from the measurements of the CP violation parameters $C_{\\pi^+\\pi^-}$ and $S_{\\pi^+\\pi^-}$ in $B^0\\to\\pi^+\\pi^-$. The U-spin breaking effect between $B^0\\to\\pi^+\\pi^-$ and $B_s^0\\to K^+K^-$ is estimated to be around 30\\%.

  18. A categorification of U_T sl(1,1) and its tensor product representations

    OpenAIRE

    Tian, Yin

    2013-01-01

    We define the Hopf superalgebra U_T sl(1,1), which is a variant of the quantum supergroup U_q sl(1,1), and its tensor product representations V_1^{\\otimes n} for n>0. We construct families of DG algebras A, B and R_n, and consider the DG categories DGP(A), DGP(B) and DGP(R_n), which are full DG subcategories of the categories of DG A-, B- and R_n-modules generated by certain distinguished projective modules. Their 0th homology categories HP(A), HP(B), and HP(R_n) are triangulated and give alg...

  19. IMPLEMENTASI MANAJEMEN PENGETAHUAN PADA SISTEM PENGELOLAAN IJAZAH DI UPBJJ-UT BOGOR

    Directory of Open Access Journals (Sweden)

    Ratna Marta Dhewi

    2015-04-01

    Full Text Available This research aimed to examine the pattern of managing document certification at Bogor regional office for the last decade, furthermore, to design the digital model which offers insights into what is required to strategically align transcript management practice at Bogor regional office. The research was conducted by purposive sampling at Bogor Regional office considering that it represents the complexity of the organization that involves only a few employees with varying computational competencies and various task capabilities. However, they have been able to implement the knowledge management systems in providing services to customers. The data of this research were primary data. Data analysis were conducted based on an ongoing basis, with the following steps: preparation of the theme of data, classification and mapping of data based on a theme that has been set up, compilation, reduction, data cleaning, incorporation into the theme of the final data, triangulation of data, and data interpretation. This research discovered that managing certification documents of graduation at Bogor regional proved to be continuously updated and improved by the management team, and supported by top level management. The finding of this research proposed that the web based digital model of the certification documents management system (from acceptance, storage to distribution is the most suitable model to be implemented at the regional offices. Penelitian ini bertujuan mendeskripsikan pola pengelolaan dokumen sertifikasi di UPBJJ-UT Bogor selama sepuluh tahun terakhir dan menemukan model digital yang paling tepat untuk pengelolaan ijazah/transkrip yang efisien di UPBJJ-UT Bogor. Penelitian ini dilakukan dari bulan Maret sampai November 2011. Pemilihan lokasi penelitian dilakukan dengan cara purposive sampling dengan mempertimbangkan bahwa UPBJJ UT Bogor dapat mewakili kompleksitas organisasi yang melibatkan hanya beberapa pegawai dengan penguasaan komputer yang

  20. Role of UTS2 gene in the genetic susceptibility to atrial fibrillation in the Chinese population.

    Science.gov (United States)

    Zhao, Jing; Ding, Wen-Hui; Chu, Song-Yun; Jiang, Jie; Zhou, Jing; Xia, Yu-Long; Wu, Lin

    2016-04-01

    Atrial fibrosis plays a key role in the inducibility and persistence of atrial fibrillation. Urotensin II (U-II/UTS2) induces cardiac fibrosis by increasing fibroblast collagen synthesis and increased U-II plasma levels have been reported in patients with atrial fibrosis. Our objective was therefore to evaluate the possible role of the UTS2 gene polymorphisms Thr21Met and Ser89Asn in the genetic susceptibility to atrial fibrillation in a Chinese population. A case-control study was designed to compare the distribution of alleles and genotypes between controls (n=197) and patients with AF (n=197). The detection of UTS2 gene polymorphisms was undertaken using the PCR-restriction fragment length polymorphism technique. We identified statistically significant differences between the atrial fibrillation and control groups with regard to the frequency of genotype variant GA at the Ser89Asn locus (OR 1.955, 95% CI 1.071 to 3.566, p=0.029). When stratified by sex, differences in genotype distribution of polymorphism Ser89Asn was only seen in men in the additive tested inheritance model (OR 2.843, 95% CI 1.273 to 6.348, p=0.011). There was a statistical difference in Met21Met, implying a potential beneficial role for atrial fibrillation in the recessive tested inheritance model among men (OR 0.260, 95% CI 0.075 to 0.89, p=0.033; AA vs GA-GG). For subjects with atrial fibrillation, the Met21Met genotype was associated with a larger anteroposterior left atrial diameter (AA vs GG, 4.12±0.62 vs 3.86±0.51, p=0.028) and a smaller left ventricular end-diastolic diameter (AA vs GG, 4.50±0.48 vs 4.78±0.49, p=0.039). Ser89Asn polymorphisms of the UTS2 gene are significantly associated with atrial fibrillation in the Chinese population. Additionally, we demonstrated that genotype Met21Met may have a potential beneficial role in atrial fibrillation. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  1. The Socio-Economic Impacts on Water Resources in the Răut River Basin

    Directory of Open Access Journals (Sweden)

    Petru Bacal

    2016-10-01

    Full Text Available The purpose of this research consists in the elucidation of spatial and economic aspects of the water use in the Răut river basin. The main topics presented in this paper are: 1 the dynamics of volume of wastewater discharged into the river Raut basin and its sections; 2 wastewater discharge by the degree of treatment; 3 spatial and branch profile of wastewater discharged: 4 existing problems in evaluation and monitoring of waste water. To achieve these objectives were used traditional methods of geographical and economic research.

  2. Testbeam studies of pre-prototype silicon strip sensors for the LHCb UT upgrade project

    CERN Document Server

    Abba, Andrea; Blusk, Steven; Britton, Thomas; Davis, Adam; Dendek, Adam; Dey, Biplab; Ely, Scott; Evans, T.; Fu, Jinlin; Gandini, Paolo; Lionetto, Federica; Manning, Peter Michael; Meadows, Brian; Mountain, Raymond; Neri, Nicola; Petruzzo, Marco; Pikies, Malgorzata; Skwarnicki, Tomasz; Szumlak, Tomasz; Wang, Jianchun

    2016-01-01

    The LHCb experiment is preparing for a major upgrade in 2018-2019. One of the key components in the upgrade is a new silicon tracker situated upstream of the analysis magnet of the experiment. The Upstream Tracker (UT) will consist of four planes of silicon strip detectors, with each plane covering an area of about 2m$^2$. An important consideration of these detectors is their performance after they have been exposed to a large radiation dose. In this article we present test beam results of pre-prototype n-in-p and p-in-n sensors that have been irradiated with doses up to 23.3 MRad.

  3. Internationality meets locality - ART IST KUKU NU UT festival in Tartu / Tanel Rander

    Index Scriptorium Estoniae

    Rander, Tanel, 1980-

    2012-01-01

    Kunstifestivalist ART IST KUKU NU UT. Näitusest "Möh? Fui! Öäk! Ossa! Vau! Eesti kaasaegse kunsti klassika" (06.09.-18.11.2012) Tartu Kunstimuuseumis. Festivali projektijuht Kaisa Eiche, kunstiline juht ja näituse kuraator Rael Artel. Näitusel osalesid Jaan Toomik, Raul Meel, Kai Kaljo, Johnson & Johnson, Anna-Stina Treumund ja Flo Kasearu. Chris Fitzpatrick'u kureeritud näitusest "Sõida tasa üle silla" (07.-30.09.2012) galeriis Noorus. Kuku Nunnu stipendiaadi Eike Epliku isikunäitusest "Tüdruk, kes kõike arnastas" (07.09.-28.10.2012) Y-galeriis

  4. Solar neutrons from the impulsive flare on 1982 June 3 at 1143 UT

    Science.gov (United States)

    Chupp, E. L.; Forrest, D. J.; Share, G. H.; Kanbach, G.; Debrunner, H.; Flueckiger, E.

    1983-01-01

    A transient flux of high energy solar neutrons from 50 MeV to about 1 GeV has been detected by the Gamma Ray Spectrometer (GRS) on the Solar Maximum Mission (SMM) satellite following an intense burst of high energy photons (less than 100 MeV) peaking at 1143:29 UT. The neutrons were also detected by the IGY neutron monitor on Jungfraujoch (Switzerland). In this paper the SMM GRS observations are summarized and compared with the Jungfraujoch neutron monitor data, and both the time dependent neutron flux at the earth and the neutron emission spectrum at the sun are estimated.

  5. Shock waves generated by the intense solar flare of 1972, August 7, 15:00 UT

    Science.gov (United States)

    Maxwell, A.; Rinehart, R.

    1974-01-01

    The dynamic radio spectrum of the class 3B solar flare of 1972, August 7, 15:00 UT, over the band 10 to 2000 MHz is examined. Type II and type IV bursts in the spectrum are interpreted in terms of a piston-driven shock, which appeared to be traveling at a velocity of about 1500 km per sec and which generated pulsations in the band 100 to 200 MHz as it passed through the corona. The progress of the shock through the interplanetary plasma was subsequently monitored by Malitson et al. with radio equipment covering the band 0.03 to 2.6 MHz on the IMP-6 satellite.

  6. Long-term changes in UT/LS ozone between the late 1970s and the 1990s deduced from the GASP and MOZAIC aircraft programs and from ozonesondes

    Directory of Open Access Journals (Sweden)

    R. Stübi

    2009-07-01

    Full Text Available We present ozone measurements of the Global Atmospheric Sampling Program (GASP performed from four commercial and one research aircraft in the late 1970s to compare them with respective measurements of the ongoing MOZAIC project. Multi-annual averages of UT/LS ozone were built using the aircraft data sets (1975–1979 and 1994–2001, and long-term changes between the 1970s and 1990s were derived by comparison. The data were binned relative to the dynamical tropopause to separate between UT and LS air masses. LS data were analysed using equivalent latitudes. In the UT, pronounced increases of 20–40% are found over the Middle East and South Asia in the spring and summer seasons. Increases are also found over Japan, Europe, and the eastern parts of the United States depending on season. LS ozone over northern mid- and high latitudes was found to be lower in the 1990s compared to the 1970s in all seasons of the year. In addition, a comparison with long-term changes deduced from ozonesondes is presented. The early 1970s European Brewer-Mast (BM sonde data agree with GASP within the range of uncertainty (UT or measured slightly less ozone (LS. In contrast, the 1990s BM sensors show consistently and significantly higher UT/LS ozone values than MOZAIC. This unequal behaviour of aircraft/sonde comparisons in the 1970s and 1990s leads to differences in the estimated long-term changes over Europe: while the comparison between GASP and MOZAIC indicates ozone changes of −5% to 10% over Europe, the sondes suggest a much larger increase of 10%–35% depending on station and season, although statistical significance is not conclusive due to data sample limitations. In contrast to the BM sondes, the Electrochemical Cell (ECC sonde at Wallops Island, USA, measured higher UT ozone than both GASP and MOZAIC. Hence, long-term changes from GASP/MOZAIC agree within the range of uncertainty with the changes deduced from Wallops Island.

  7. Long-term changes in UT/LS ozone between the late 1970s and the 1990s deduced from the GASP and MOZAIC aircraft programs and from ozonesondes

    Science.gov (United States)

    Schnadt Poberaj, C.; Staehelin, J.; Brunner, D.; Thouret, V.; de Backer, H.; Stübi, R.

    2009-07-01

    We present ozone measurements of the Global Atmospheric Sampling Program (GASP) performed from four commercial and one research aircraft in the late 1970s to compare them with respective measurements of the ongoing MOZAIC project. Multi-annual averages of UT/LS ozone were built using the aircraft data sets (1975-1979 and 1994-2001), and long-term changes between the 1970s and 1990s were derived by comparison. The data were binned relative to the dynamical tropopause to separate between UT and LS air masses. LS data were analysed using equivalent latitudes. In the UT, pronounced increases of 20-40% are found over the Middle East and South Asia in the spring and summer seasons. Increases are also found over Japan, Europe, and the eastern parts of the United States depending on season. LS ozone over northern mid- and high latitudes was found to be lower in the 1990s compared to the 1970s in all seasons of the year. In addition, a comparison with long-term changes deduced from ozonesondes is presented. The early 1970s European Brewer-Mast (BM) sonde data agree with GASP within the range of uncertainty (UT) or measured slightly less ozone (LS). In contrast, the 1990s BM sensors show consistently and significantly higher UT/LS ozone values than MOZAIC. This unequal behaviour of aircraft/sonde comparisons in the 1970s and 1990s leads to differences in the estimated long-term changes over Europe: while the comparison between GASP and MOZAIC indicates ozone changes of -5% to 10% over Europe, the sondes suggest a much larger increase of 10%-35% depending on station and season, although statistical significance is not conclusive due to data sample limitations. In contrast to the BM sondes, the Electrochemical Cell (ECC) sonde at Wallops Island, USA, measured higher UT ozone than both GASP and MOZAIC. Hence, long-term changes from GASP/MOZAIC agree within the range of uncertainty with the changes deduced from Wallops Island.

  8. Gamma-Ray Telescopes: 400 Years of Astronomical Telescopes

    Science.gov (United States)

    Gehrels, Neil; Cannizzo, John K.

    2010-01-01

    The last half-century has seen dramatic developments in gamma-ray telescopes, from their initial conception and development through to their blossoming into full maturity as a potent research tool in astronomy. Gamma-ray telescopes are leading research in diverse areas such as gamma-ray bursts, blazars, Galactic transients, and the Galactic distribution of Al-26.

  9. Building Medium Size Telescope Structures for the Cherenkov Telescope Array

    CERN Document Server

    Schulz, A; Oakes, L; Schlenstedt, S; Schwanke, U

    2016-01-01

    The Cherenkov Telescope Array (CTA) is the future instrument in ground-based gamma-ray astronomy in the energy range from 20 GeV to 300 TeV. Its sensitivity will surpass that of current generation experiments by a factor $\\sim$10, facilitated by telescopes of three sizes. The performance in the core energy regime will be dominated by Medium Size Telescopes (MST) with a reflector of 12 m diameter. A full-size mechanical prototype of the telescope structure has been constructed in Berlin. The performance of the prototype is being evaluated and optimisations, among others, facilitating the assembly procedure and mass production possibilities are being implemented. We present the current status of the developments from prototyping towards pre-production telescopes, which will be deployed at the final site.

  10. The neutrino telescope ANTARES

    Directory of Open Access Journals (Sweden)

    Gleixner Andreas

    2014-04-01

    Full Text Available The ANTARES neutrino telescope is currently the largest neutrino detector in the Northern Hemisphere. The detector consists of a three-dimensional array of 885 photomultiplier tubes, distributed along 12 lines, located at a depth of 2500 m in the Mediterranean Sea. The purpose of the experiment is the detection of high-energy cosmic neutrinos. The detection principle is based on the observation of Cherenkov-Light emitted by muons resulting from charged-current interactions of muon neutrinos in the vicinity of the detection volume. The main scientific targets of ANTARES include the search for astrophysical neutrino point sources, the measurement of the diffuse neutrino flux and the indirect search for dark matter.

  11. The ANTARES neutrino telescope

    CERN Document Server

    Zornoza, Juan de Dios

    2012-01-01

    The ANTARES collaboration completed the installation of the first neutrino detector in the sea in 2008. It consists of a three dimensional array of 885 photomultipliers to gather the Cherenkov photons induced by relativistic muons produced in charged-current interactions of high energy neutrinos close to/in the detector. The scientific scope of neutrino telescopes is very broad: the origin of cosmic rays, the origin of the TeV photons observed in many astrophysical sources or the nature of dark matter. The data collected up to now have allowed us to produce a rich output of physics results, including the map of the neutrino sky of the Southern hemisphere, search for correlations with GRBs, flaring sources, gravitational waves, limits on the flux produced by dark matter self-annihilations, etc. In this paper a review of these results is presented.

  12. Composite telescope technology

    Science.gov (United States)

    Chen, Peter C.; Rabin, Douglas

    2014-07-01

    We report the development of optical mirrors based on polymer matrix composite materials. Advantages of this technology are low cost and versatility. By using appropriate combinations of polymers and various metallic and nonmetallic particles and fibers, the properties of the materials can be tailored to suit a wide variety of applications. We report the fabrication and testing of flat and curved mirrors made with metal powders, multiple mirrors replicated with high degree of uniformity from the same mandrels, cryogenic testing, mirrors made of ferromagnetic materials that can be actively or adaptively controlled by non-contact actuation, optics with very smooth surfaces made by replication, and by spincasting. We discuss development of a new generation of ultra-compact, low power active optics and 3D printing of athermal telescopes.

  13. Telescopes for the 1980s

    Science.gov (United States)

    Neugebauer, G.

    In the last decades, astronomy has been changed in a number of significant ways. The number of large optical telescopes with diameters on the order of or larger than 2.3 m has increased from 3 shortly after World War II to about 20 at the present time. Whereas prewar astronomy was largely devoted to the visual wavelengths (0.3-0.8 μm), astronomical observations currently span the range from γ ray wavelengths to the longest radio wavelengths. Most significantly, astronomy outside conventional optical astronomy has developed into sophisticated disciplines rather than experimental explorations. Many of the observational advances at the forefront of astronomy now come from other than visual observations. Along with these changes have come fundamental changes in visual astronomy itself. Observations with photographic plates are the exception rather than the rule at most large observatories. Instead, electronic cameras are in common use. A second change, especially in the United States, is that the funding has gone from largely private funding (e.g., the Carnegie Institution of Washington) to funding with the government providing a main share of the support. Indeed, the government has provided the total funding for those disciplines, like X ray astronomy, which use space-borne platforms. These changes have also affected the character of doing astronomy, and astronomers have become much more politically active on the national science scene.

  14. Islamic fundamentalism, nation- state and global citizenship: the case of Hizb ut-Tahrir

    Directory of Open Access Journals (Sweden)

    Asep Muhammad Iqbal

    2016-06-01

    Full Text Available Contrary to common understanding among observers, this essay argues that Islamic fundamentalism is not anti-globalization movement, but rather as parts, participants, and interpreters of globalization. Focusing on the case of Hizb ut-Tahrir, it shows that regardless of its utopian nature of the ideology it pro- motes, Islamic fundamentalism is a globalizing force that constitutes a return of old world religions to modern society, which is characterised by its rejec- tion of the validity of nation-states and vision of a global citizenship through the establishment of Islamic Caliphate as a single global community of believ- ers (ummah with its universalistic rules and laws within contemporary Mus- lim world. Berbeda dari pandangan yang sejauh ini banyak dikemukakan oleh para pengamat, tulisan ini berargumen bahwa fundamentalisme Islam bukan merupakan gerakan anti-globalisasi, melainkan justru sebagai bagian, partisipan dan penafsir fenomena globalisasi. Dengan memfokuskan analisisnya pada kasus Hizb ut-Tahrir, tulisan ini menunjukkan bahwa terlepas dari sifat utopian ideologi yang diusungnya, gerakan fundamentalisme Islam tidak diragukan lagi merupakan sebuah kekuatan globalisasi yang mewakili kembalinya agama besar dunia ke masyarakat modern, yang bercirikan penolakan atas validitas negara- bangsa dan visi kewarganegaraan global melalui pembentukan komunitas glo- bal umat Islam dalam bentuk khilafah Islam dengan aturan dan hukum universalnya dalam dunia Islam kontemporer.

  15. Bio-medical waste management in the U.T., Chandigarh.

    Science.gov (United States)

    Singh, Kamaljit; Arora, Shakti Kumar; Dhadwal, P J S; Singla, Ashwani; John, Siby

    2004-01-01

    Investigations were carried out to assess the generation and disposal of biomedical waste in the various medical establishments in the urban and rural areas of the U.T. Chandigarh. It was found that there were 474 medical establishments in the U.T., Chandigarh including Nursing Homes, Clinics, Dispensaries, Pathological labs., Hospitals, Veterinary Institutions and Animal houses. The total quantity of bio-medical waste generated in Chandigarh is 811.35 kg/day and the rate of generation of bio-medical waste varies from 0.06 kg/day/bed to 0.25 kg/day/bed. Though the major hospitals are equipped with incinerators, proper bio-medical waste management system is yet to be implemented. The medical establishments in the rural area and smaller ones in the urban area dispose off their bio-medical waste along with municipal solid waste and no waste management system exists. It is recommended that an integrated waste management plan using the three incinerators installed at the major hospitals can safely dispose off the total bio-medical waste generated in the city.

  16. The next generation Cherenkov Telescope Array observatory: CTA

    CERN Document Server

    Vercellone, Stefano

    2014-01-01

    The Cherenkov Telescope Array (CTA) is a large collaborative effort aimed at the design and operation of an observatory dedicated to the VHE gamma-ray astrophysics in the energy range 30 GeV-100 TeV, which will improve by about one order of magnitude the sensitivity with respect to the current major arrays (H.E.S.S., MAGIC, and VERITAS). In order to achieve such improved performance, for both the northern and southern CTA sites, four units of 23m diameter Large Size Telescopes (LSTs) will be deployed close to the centre of the array with telescopes separated by about 100m. A larger number (about 25 units) of 12m Medium Size Telescopes (MSTs, separated by about 150m), will cover a larger area. The southern site will also include up to 24 Schwarzschild-Couder dual-mirror medium-size Telescopes (SCTs) with the primary mirror diameter of 9.5m. Above a few TeV, the Cherenkov light intensity is such that showers can be detected even well outside the light pool by telescopes significantly smaller than the MSTs. To a...

  17. A novel fully differential telescopic operational transconductance amplifier

    Energy Technology Data Exchange (ETDEWEB)

    Li Tianwang; Jiang Jinguang [Department of Integrated Circuits and Communication Software, International School of Software, Wuhan University, Wuhan 430079 (China); Ye Bo, E-mail: jgjiang95@yahoo.com.c [Faculty of Computer and Information Engineering, Shanghai University of Electric Power, Shanghai 200090 (China)

    2009-08-15

    A novel fully differential telescopic operational transconductance amplifier (OTA) is proposed. An additional PMOS differential pair is introduced to improve the unit-gain bandwidth of the telescopic amplifier. At the same time, the slew rate is enhanced by the auxiliary slew rate boost circuits. The proposed OTA is designed in a 0.18{mu}m CMOS process. Simulation results show that there is a 49% improvement in the unit-gain bandwidth compared to that of a conventional OTA; moreover, the DC gain and the slew rate are also enhanced. (semiconductor integrated circuits)

  18. Infrared up-conversion telescope

    DEFF Research Database (Denmark)

    2014-01-01

    There is presented to an up-conversion infrared telescope (110) arranged for imaging an associated scene (130), wherein the up-conversion infrared telescope (110) comprises a non-linear crystal (120) arranged for up-conversion of infrared electromagnetic radiation, and wherein a first optical...

  19. European Solar Telescope: Progress status

    NARCIS (Netherlands)

    Collados, M.; Bettonvil, F.C.M.; Cavaller, L.; Ermolli, I.; Gelly, B.; Pérez, A.; Socas-Navarro, H.; Soltau, D.; Volkmer, R.

    2010-01-01

    In this paper, the present status of the development of the design of the European Solar Telescope is described. The telescope is devised to have the best possible angular resolution and polarimetric performance, maximizing the throughput of the whole system. To that aim, adaptive optics and multi-c

  20. Short-term prediction of UT1-UTC by combination of the grey model and neural networks

    Science.gov (United States)

    Lei, Yu; Guo, Min; Hu, Dan-dan; Cai, Hong-bing; Zhao, Dan-ning; Hu, Zhao-peng; Gao, Yu-ping

    2017-01-01

    UT1-UTC predictions especially short-term predictions are essential in various fields linked to reference systems such as space navigation and precise orbit determinations of artificial Earth satellites. In this paper, an integrated model combining the grey model GM(1, 1) and neural networks (NN) are proposed for predicting UT1-UTC. In this approach, the effects of the Solid Earth tides and ocean tides together with leap seconds are first removed from observed UT1-UTC data to derive UT1R-TAI. Next the derived UT1R-TAI time-series are de-trended using the GM(1, 1) and then residuals are obtained. Then the residuals are used to train a network. The subsequently predicted residuals are added to the GM(1, 1) to obtain the UT1R-TAI predictions. Finally, the predicted UT1R-TAI are corrected for the tides together with leap seconds to obtain UT1-UTC predictions. The daily values of UT1-UTC between January 7, 2010 and August 6, 2016 from the International Earth Rotation and Reference Systems Service (IERS) 08 C04 series are used for modeling and validation of the proposed model. The results of the predictions up to 30 days in the future are analyzed and compared with those by the GM(1, 1)-only model and combination of the least-squares (LS) extrapolation of the harmonic model including the linear part, annual and semi-annual oscillations and NN. It is found that the proposed model outperforms the other two solutions. In addition, the predictions are compared with those from the Earth Orientation Parameters Prediction Comparison Campaign (EOP PCC) lasting from October 1, 2005 to February 28, 2008. The results show that the prediction accuracy is inferior to that of those methods taking into account atmospheric angular momentum (AAM), i.e., Kalman filter and adaptive transform from AAM to LODR, but noticeably better that of the other existing methods and techniques, e.g., autoregressive filtering and least-squares collocation.

  1. Neuropilin-1 forms complexes with vascular endothelial growth factor receptor-2 during megakaryocytic differentiation of UT-7/TPO cells

    Energy Technology Data Exchange (ETDEWEB)

    Ohsaka, Akimichi, E-mail: ohsaka@juntendo.ac.jp [Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Hirota-Komatsu, Satoko; Shibata, Miki [Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan); Komatsu, Norio [Department of Hematology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421 (Japan)

    2009-12-25

    We investigated whether the gene expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR and neuropilin-1 [NRP-1]) could be specifically regulated during the megakaryocytic differentiation of human thrombopoietin (TPO)-dependent UT-7/TPO cells. Undifferentiated UT-7/TPO cells expressed a functional VEGFR-2, leading to VEGF binding and VEGF{sub 165}-induced tyrosine phosphorylation, cell proliferation, and apoptosis inhibition. The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2. VEGF{sub 165} promoted the formation of complexes containing NRP-1 and VEGFR-2 in undifferentiated UT-7/TPO cells in a dose-dependent manner. Unlike human umbilical vein endothelial cells, PMA-differentiated UT-7/TPO cells exhibited complex formation between NRP-1 and VEGFR-2 even in the absence of VEGF{sub 165}. These findings suggest that NRP-1-VEGFR-2-complex formation may contribute to effective cellular functions mediated by VEGF{sub 165} in megakaryocytic cells.

  2. Neuropilin-1 forms complexes with vascular endothelial growth factor receptor-2 during megakaryocytic differentiation of UT-7/TPO cells.

    Science.gov (United States)

    Ohsaka, Akimichi; Hirota-Komatsu, Satoko; Shibata, Miki; Komatsu, Norio

    2009-12-25

    We investigated whether the gene expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR and neuropilin-1 [NRP-1]) could be specifically regulated during the megakaryocytic differentiation of human thrombopoietin (TPO)-dependent UT-7/TPO cells. Undifferentiated UT-7/TPO cells expressed a functional VEGFR-2, leading to VEGF binding and VEGF(165)-induced tyrosine phosphorylation, cell proliferation, and apoptosis inhibition. The megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of NRP-1 mRNA and protein expression and by an increase in VEGF-binding activity, which was mainly mediated by VEGFR-2. VEGF(165) promoted the formation of complexes containing NRP-1 and VEGFR-2 in undifferentiated UT-7/TPO cells in a dose-dependent manner. Unlike human umbilical vein endothelial cells, PMA-differentiated UT-7/TPO cells exhibited complex formation between NRP-1 and VEGFR-2 even in the absence of VEGF(165). These findings suggest that NRP-1-VEGFR-2-complex formation may contribute to effective cellular functions mediated by VEGF(165) in megakaryocytic cells.

  3. Seismic Imager Space Telescope

    Science.gov (United States)

    Sidick, Erkin; Coste, Keith; Cunningham, J.; Sievers,Michael W.; Agnes, Gregory S.; Polanco, Otto R.; Green, Joseph J.; Cameron, Bruce A.; Redding, David C.; Avouac, Jean Philippe; Ampuero, Jean Paul; Leprince, Sebastien; Michel, Remi

    2012-01-01

    A concept has been developed for a geostationary seismic imager (GSI), a space telescope in geostationary orbit above the Pacific coast of the Americas that would provide movies of many large earthquakes occurring in the area from Southern Chile to Southern Alaska. The GSI movies would cover a field of view as long as 300 km, at a spatial resolution of 3 to 15 m and a temporal resolution of 1 to 2 Hz, which is sufficient for accurate measurement of surface displacements and photometric changes induced by seismic waves. Computer processing of the movie images would exploit these dynamic changes to accurately measure the rapidly evolving surface waves and surface ruptures as they happen. These measurements would provide key information to advance the understanding of the mechanisms governing earthquake ruptures, and the propagation and arrest of damaging seismic waves. GSI operational strategy is to react to earthquakes detected by ground seismometers, slewing the satellite to point at the epicenters of earthquakes above a certain magnitude. Some of these earthquakes will be foreshocks of larger earthquakes; these will be observed, as the spacecraft would have been pointed in the right direction. This strategy was tested against the historical record for the Pacific coast of the Americas, from 1973 until the present. Based on the seismicity recorded during this time period, a GSI mission with a lifetime of 10 years could have been in position to observe at least 13 (22 on average) earthquakes of magnitude larger than 6, and at least one (2 on average) earthquake of magnitude larger than 7. A GSI would provide data unprecedented in its extent and temporal and spatial resolution. It would provide this data for some of the world's most seismically active regions, and do so better and at a lower cost than could be done with ground-based instrumentation. A GSI would revolutionize the understanding of earthquake dynamics, perhaps leading ultimately to effective warning

  4. Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation.

    Science.gov (United States)

    Blount, Mitsi A; Mistry, Abinash C; Fröhlich, Otto; Price, S Russ; Chen, Guangping; Sands, Jeff M; Klein, Janet D

    2008-07-01

    The UT-A1 urea transporter plays an important role in the urine concentrating mechanism. Vasopressin (or cAMP) increases urea permeability in perfused terminal inner medullary collecting ducts and increases the abundance of phosphorylated UT-A1, suggesting regulation by phosphorylation. We performed a phosphopeptide analysis that strongly suggested that a PKA consensus site(s) in the central loop region of UT-A1 was/were phosphorylated. Serine 486 was most strongly identified, with other potential sites at serine 499 and threonine 524. Phosphomutation constructs of each residue were made and transiently transfected into LLC-PK1 cells to assay for UT-A1 phosphorylation. The basal level of UT-A1 phosphorylation was unaltered by mutation of these sites. We injected oocytes, assayed [14C]urea flux, and determined that mutation of these sites did not alter basal urea transport activity. Next, we tested the effect of stimulating cAMP production with forskolin. Forskolin increased wild-type UT-A1 and T524A phosphorylation in LLC-PK1 cells and increased urea flux in oocytes. In contrast, the S486A and S499A mutants demonstrated loss of forskolin-stimulated UT-A1 phosphorylation and reduced urea flux. In LLC-PK1 cells, we assessed biotinylated UT-A1. Wild-type UT-A1, S486A, and S499A accumulated in the membrane in response to forskolin. However, in the S486A/S499A double mutant, forskolin-stimulated UT-A1 membrane accumulation and urea flux were totally blocked. We conclude that the phosphorylation of UT-A1 on both serines 486 and 499 is important for activity and that this phosphorylation may be involved in UT-A1 membrane accumulation.

  5. Operating a heterogeneous telescope network

    Science.gov (United States)

    Allan, Alasdair; Bischoff, Karsten; Burgdorf, Martin; Cavanagh, Brad; Christian, Damien; Clay, Neil; Dickens, Rob; Economou, Frossie; Fadavi, Mehri; Frazer, Stephen; Granzer, Thomas; Grosvenor, Sandy; Hessman, Frederic V.; Jenness, Tim; Koratkar, Anuradha; Lehner, Matthew; Mottram, Chris; Naylor, Tim; Saunders, Eric S.; Solomos, Nikolaos; Steele, Iain A.; Tuparev, Georg; Vestrand, W. Thomas; White, Robert R.; Yost, Sarah

    2006-06-01

    In the last few years the ubiquitous availability of high bandwidth networks has changed the way both robotic and non-robotic telescopes operate, with single isolated telescopes being integrated into expanding "smart" telescope networks that can span continents and respond to transient events in seconds. The Heterogeneous Telescope Networks (HTN)* Consortium represents a number of major research groups in the field of robotic telescopes, and together we are proposing a standards based approach to providing interoperability between the existing proprietary telescope networks. We further propose standards for interoperability, and integration with, the emerging Virtual Observatory. We present the results of the first interoperability meeting held last year and discuss the protocol and transport standards agreed at the meeting, which deals with the complex issue of how to optimally schedule observations on geographically distributed resources. We discuss a free market approach to this scheduling problem, which must initially be based on ad-hoc agreements between the participants in the network, but which may eventually expand into a electronic market for the exchange of telescope time.

  6. Genomic organization and genomic structural rearrangements of Sphingobium japonicum UT26, an archetypal γ-hexachlorocyclohexane-degrading bacterium.

    Science.gov (United States)

    Nagata, Yuji; Natsui, Shunsuke; Endo, Ryo; Ohtsubo, Yoshiyuki; Ichikawa, Natsuko; Ankai, Akiho; Oguchi, Akio; Fukui, Shigehiro; Fujita, Nobuyuki; Tsuda, Masataka

    2011-12-10

    The complete genome sequencing of a γ-hexachlorocyclohexane-degrading strain, Sphingobium japonicum UT26, revealed that the genome consists of two circular chromosomes [with sizes of 3.5 Mb (Chr1) and 682kb (Chr2)], a 191-kb large plasmid (pCHQ1), and two small plasmids with sizes of 32 and 5kb. The lin genes are dispersed on Chr1, Chr2, and pCHQ1. Comparison of the UT26 genome with those of other sphingomonad strains demonstrated that the "specific"lin genes for conversion of γ-HCH to β-ketoadipate (linA, linB, linC, linRED, and linF) are located on the DNA regions unique to the UT26 genome, suggesting the acquisition of these lin genes by horizontal transfer events. On the other hand, linGHIJ and linKLMN are located on the regions conserved in the genomes of sphingomonads, suggesting that the linGHIJ-encoded β-ketoadipate pathway and the LinKLMN-type ABC transporter system are involved in core functions of sphingomonads. Based on these results, we propose a hypothesis that UT26 was created by recruiting the specific lin genes into a strain having core functions of sphingomonads. Most of the specific lin genes in UT26 are associated with IS6100. Our analysis of spontaneous linA-, linC-, and linRED-deletion mutants of UT26 revealed the involvement of IS6100 in their deduced genome rearrangements. These facts strongly suggest that IS6100 plays important roles both in the dissemination of the specific lin genes and in the genome rearrangements.

  7. The human megakaryocytic cell line UT-7/TPO expresses functional platelet agonist signals mediated through GPVI and thromboxane receptor.

    Science.gov (United States)

    Kawaguchi, Tatsuya; Hashimoto, Ryuji; Yokota, Hiroshi

    2010-09-01

    We have demonstrated that a unique megakaryocytic cell line UT-7/TPO could respond to one of the primary platelet signals through GP (glycoprotein) VI and a secondary signal of the AA (arachidonic acid) cascade. Unlike other megakaryocytic cell lines, UT-7/TPO was found to express GPVI and its associate signal molecule of FcRgamma (Fc receptor gamma chain). When UT-7/TPO was stimulated with the GPVI agonist convulxin, the [Ca2+]i (intracellular Ca2+) was elevated in a convulxin concentration-dependent manner, and [Ca2+]i elevation was blocked by pretreatment with the Src family kinase inhibitor PP2 and the phospholipase inhibitor U73122. These results strongly indicate that endogenously expressed GPVI signal molecules are functional in UT-7/TPO. Concerning the AA cascade, the expression of COX (cyclooxygenase)-1 and TX (thromboxane) synthase was observed, and this cell line was able to produce TX by exogenous AA, followed by [Ca2+]i elevation mediated through the TX receptor. It is worth noting that convulxin stimulation did not cause TX generation, even through the GPVI pathway and the AA cascade are functional in this cell line. As there are many reports that convulxin-stimulated platelets failed to produce TX, it is suggested that UT-7/TPO has the same property as the platelets in regards to convulxin stimulation. Thus, UT-7/TPO is useful for the observation of both the GPVI pathway and AA cascade without requiring either the induction of differentiation or GPVI transfection. Furthermore, this cell line provides a new tool for research on platelet activation signals.

  8. Why systems engineering on telescopes?

    Science.gov (United States)

    Swart, Gerhard P.; Meiring, Jacobus G.

    2003-02-01

    Although Systems Engineering has been widely applied to the defence industry, many other projects are unaware of its potential benefits when correctly applied, assuming that it is an expensive luxury. It seems that except in a few instances, telescope projects are no exception, prompting the writing of this paper. The authors postulate that classical Systems Engineering can and should be tailored, and then applied to telescope projects, leading to cost, schedule and technical benefits. This paper explores the essence of Systems Engineering and how it can be applied to any complex development project. The authors cite real-world Systems Engineering examples from the Southern African Large Telescope (SALT). The SALT project is the development and construction of a 10m-class telescope at the price of a 4m telescope. Although SALT resembles the groundbreaking Hobby-Eberly Telescope (HET) in Texas, the project team are attempting several challenging changes to the original design, requiring a focussed engineering approach and discernment in the definition of the telescope requirements. Following a tailored Systems Engineering approach on this project has already enhanced the quality of decisions made, improved the fidelity of contractual specifications for subsystems, and established criteria testing their performance. Systems Engineering, as applied on SALT, is a structured development process, where requirements are formally defined before the award of subsystem developmental contracts. During this process conceptual design, modeling and prototyping are performed to ensure that the requirements were realistic and accurate. Design reviews are held where the designs are checked for compliance with the requirements. Supplier factory and on-site testing are followed by integrated telescope testing, to verify system performance against the specifications. Although the SALT project is still far from completion, the authors are confident that the present benefits from

  9. Middle and long-term prediction of UT1-UTC based on combination of Gray Model and Autoregressive Integrated Moving Average

    Science.gov (United States)

    Jia, Song; Xu, Tian-he; Sun, Zhang-zhen; Li, Jia-jing

    2017-02-01

    UT1-UTC is an important part of the Earth Orientation Parameters (EOP). The high-precision predictions of UT1-UTC play a key role in practical applications of deep space exploration, spacecraft tracking and satellite navigation and positioning. In this paper, a new prediction method with combination of Gray Model (GM(1, 1)) and Autoregressive Integrated Moving Average (ARIMA) is developed. The main idea is as following. Firstly, the UT1-UTC data are preprocessed by removing the leap second and Earth's zonal harmonic tidal to get UT1R-TAI data. Periodic terms are estimated and removed by the least square to get UT2R-TAI. Then the linear terms of UT2R-TAI data are modeled by the GM(1, 1), and the residual terms are modeled by the ARIMA. Finally, the UT2R-TAI prediction can be performed based on the combined model of GM(1, 1) and ARIMA, and the UT1-UTC predictions are obtained by adding the corresponding periodic terms, leap second correction and the Earth's zonal harmonic tidal correction. The results show that the proposed model can be used to predict UT1-UTC effectively with higher middle and long-term (from 32 to 360 days) accuracy than those of LS + AR, LS + MAR and WLS + MAR.

  10. Skylab Apollo Telescope Mount Spar and Sun End

    Science.gov (United States)

    1971-01-01

    The Apollo Telescope Mount (ATM) was designed and developed by the Marshall Space Flight Center and served as the primary scientific instrument unit aboard Skylab (1973-1979). The ATM contained eight complex astronomical instruments designed to observe the Sun over a wide spectrum from visible light to x-rays. This image depicts the sun end and spar of the ATM flight unit showing individual telescopes. All solar telescopes, the fine Sun sensors, and some auxiliary systems are mounted on the spar, a cruciform lightweight perforated metal mounting panel that divides the canister lengthwise into four equal compartments. The spar assembly was nested inside a cylindrical canister that fit into a complex frame named the rack, and was protected by the solar shield.

  11. Formation flight astronomical survey telescope

    Science.gov (United States)

    Tsunemi, Hiroshi

    2012-03-01

    Formation Flight Astronomical Survey Telescope (FFAST) is a project for hard X-ray observation. It consists of two small satellites; one (telescope satellite) has a super mirror covering the energy range up to 80 keV while the other (detector satellite) has an scintillator deposited CCD (SDCCD) having good spatial resolution and high efficiency up to 100 keV. Two satellites will be put into individual Kepler orbits forming an X-ray telescope with a focal length of 20 m. They will be not in pointing mode but in survey mode to cover a large sky region.

  12. The Automatic Telescope Network (ATN)

    CERN Document Server

    Mattox, J R

    1999-01-01

    Because of the scheduled GLAST mission by NASA, there is strong scientific justification for preparation for very extensive blazar monitoring in the optical bands to exploit the opportunity to learn about blazars through the correlation of variability of the gamma-ray flux with flux at lower frequencies. Current optical facilities do not provide the required capability.Developments in technology have enabled astronomers to readily deploy automatic telescopes. The effort to create an Automatic Telescope Network (ATN) for blazar monitoring in the GLAST era is described. Other scientific applications of the networks of automatic telescopes are discussed. The potential of the ATN for science education is also discussed.

  13. Bhavnagar Telescope: the most widely travelled telescope in the country

    CERN Document Server

    Rao, N Kameswara; Vagiswari, A

    2014-01-01

    In the last decade of the 19th century Maharaja Takhtasingji Observatory was built at Poona (1888-1912) under the supervision of K.D.Naegamavala, with the grant from Maharaja of Bhavnagar (from where the name Bhavnagar Telescope must have originated. The story of this telescope from its inception to the current status is traced. IIA Archives has been extensively used to resource information for this note.

  14. Ice Middleware in the New Solar Telescope's Telescope Control System

    Science.gov (United States)

    Shumko, S.

    2009-09-01

    The Big Bear Solar Observatory (BBSO) is now in the process of assembling and aligning its 1.6 m New Solar Telescope (NST). There are many challenges controlling NST and one of them is establishing reliable and robust communications between different parts of the Telescope Control System (TCS). For our TCS we selected Ice (Internet communication engine) from ZeroC, Inc. In this paper we discuss advantages of the Ice middleware, details of implementation and problems we face implementing it.

  15. MODEL OPTIMASI PEMETAAN MATA KULIAH BERPRASYARAT UNTUK RENCANA STUDI MAHASISWA (STUDI KASUS PROGRAM STUDI MATEMATIKA FMIPA UT

    Directory of Open Access Journals (Sweden)

    Asmara Iriani Tarigan

    2015-04-01

    Full Text Available Universitas Terbuka (UT sebagai perguruan tinggi yang menerapkan sistem belajar jarak jauh menyusun kurikulum program pendidikannya berbeda dengan perguruan tinggi yang mempunyai sistem belajar tatap muka. Mahasiswa UT diberikan kebebasan dalam memilih dan menentukan mata kuliah untuk diregistrasikan pada satu semester. Dalam kurikulum program studi di UT terlihat bahwa terdapat mata kuliah yang mempunyai hubungan keterkaitan materi antarmata kuliah. Hubungan tersebut digambarkan sebagai hubungan prasyarat antarmata kuliah. Untuk membuat rencana studi, mahasiswa perlu mengetahui hubungan keterkaitan materi antarmata kuliah tersebut sehingga dapat menentukan mata kuliah yang akan diregistrasi pada suatu semester. Artikel ini mengidentifikasi keterkaitan materi antarmata kuliah untuk dipetakan dalam rencana studi. Untuk memetakan mata kuliah berprasyarat tersebut perlu dilakukan optimasi pemetaan mata kuliah. Tujuan pengembangan model optimasi ini adalah untuk memaksimalkan hubungan keterkaitan materi dengan memetakan mata kuliah berprasyarat secara berurutan. Hal ini juga berarti meminimalkan jarak antarsemester urutan mata kuliah berprasyarat. Model optimasi yang dikembangkan berupa Integer Linear Programming. Model tersebut kemudian diimplementasikan pada kurikulum Program Studi Matematika FMIPA UT. Hasil simulasinya berupa rencana studi bagi mahasiswa Program Studi tersebut. Dari analisis hasil simulasi diperoleh rencana studi dengan jumlah maksimal 21 dan 23 SKS per semester merupakan pilihan terbaik bagi mahasiswa. Universitas Terbuka (UT as an open and distance learning institution has curriculum that different from face to face universities. UTs students can take any course since UT offers all courses in any semester. Some courses are prerequisite for some other courses. Students need to be careful in taking the courses because some courses also have same schedule in examination. Besides, they also need to consider the courses that have

  16. Realismo utópico: o público e o intertransdisciplinar

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo W. Wanderley

    2013-01-01

    Full Text Available Selecionei, para a análise do tema, a estratégia do realismo utópico para compreensão e enfrentamento das questões da nutrição e pobreza. O texto abrange duas partes. A primeira traz argumentos sobre o conceito de utopia, entendida como inédito viável (Paulo Freire e antecipação (Jerzi Szachi, e complementa com o sentido do público e seus atributos básicos: universalidade, visibilidade social, controle social, democratização, sustentabilidade e cultura cívica. A segunda parte trata das noções de interdisciplinaridade e transdisciplinaridade, essenciais para interpretar a temática selecionada por buscar a integração das diversas áreas científicas.

  17. Islamist Distortions: Hizb ut- Tahrir a Breeding Ground for Al- Qaida Recruitment

    Directory of Open Access Journals (Sweden)

    Krishna Mungur

    2009-01-01

    Full Text Available In 1953, a radical splinter organization from the Muslim Brotherhood,Hizb ut-Tahrir (HuT, was founded by the Al-Azhar University (Cairo,Egypt educated jurist Sheikh Taqiuddin an-Nabhani who criticized theMuslim Brotherhood for collaborating with Egyptian secularists, such as Gamal Abdel Nasser. A sizable portion of the more radical members of the Muslim Brotherhood broke away, to join Nabhani's budding movement. Today, HuT is known to operate in more than forty countries, calling for the restoration of the Islamic Caliphate, with a history of violence and links to violent terrorist organizations. Given increasing tensions in the region over the presence of coalition troops, Predator drone airstrikes, a destabilized Pakistan, and lawless regions in Afghanistan, HuT is well positioned to amplify the strategic threat to coalition forces serving in the Pakistan and Afghanistan theaters.

  18. New customizable phased array UT instrument opens door for furthering research and better industrial implementation

    Science.gov (United States)

    Dao, Gavin; Ginzel, Robert

    2014-02-01

    Phased array UT as an inspection technique in itself continues to gain wide acceptance. However, there is much room for improvement in terms of implementation of Phased Array (PA) technology for every unique NDT application across several industries (e.g. oil and petroleum, nuclear and power generation, steel manufacturing, etc.). Having full control of the phased array instrument and customizing a software solution is necessary for more seamless and efficient inspections, from setting the PA parameters, collecting data and reporting, to the final analysis. NDT researchers and academics also need a flexible and open platform to be able to control various aspects of the phased array process. A high performance instrument with advanced PA features, faster data rates, a smaller form factor, and capability to adapt to specific applications, will be discussed.

  19. New customizable phased array UT instrument opens door for furthering research and better industrial implementation

    Energy Technology Data Exchange (ETDEWEB)

    Dao, Gavin [Advanced OEM Solutions, 8044 Montgomery Road 700, Cincinnati OH 45236 (United States); Ginzel, Robert [Eclipse Scientific, 97 Randall, Waterloo, Ontario N2V 1C5 (Canada)

    2014-02-18

    Phased array UT as an inspection technique in itself continues to gain wide acceptance. However, there is much room for improvement in terms of implementation of Phased Array (PA) technology for every unique NDT application across several industries (e.g. oil and petroleum, nuclear and power generation, steel manufacturing, etc.). Having full control of the phased array instrument and customizing a software solution is necessary for more seamless and efficient inspections, from setting the PA parameters, collecting data and reporting, to the final analysis. NDT researchers and academics also need a flexible and open platform to be able to control various aspects of the phased array process. A high performance instrument with advanced PA features, faster data rates, a smaller form factor, and capability to adapt to specific applications, will be discussed.

  20. Reconnection Guide Field and Quadrupolar Structure Observed by MMS on 16 October 2015 at 1307 UT

    Science.gov (United States)

    Denton, R. E.; Sonnerup, B. U. O.; Hasagawa, H.; Phan, T. D.; Russell, C. T.; Strangeway, R. J.; Giles, B. L.; Torbert, R. B.

    2016-01-01

    We estimate the guide field near the X point, B(sub M0), for a magnetopause crossing by the Magnetospheric Multiscale (MMS) spacecraft at 1307 UT on 16 October 2015 that showed features of electron-scale reconnection. This component of the magnetic field is normal to the reconnection plane L-N containing the reconnection magnetic field, B(sub L), and the direction e(sub N) normal to the current sheet. The B(sub M) field component appears to approximately have quadrupolar structure close to the X point. Using several different methods to estimate values of the guide field near the X point, some of which use an assumed quadrupolar symmetry, we find values ranging between -3.1 nT and -1.2 nT, with a nominal value of about -2.5 nT. The rough consistency of these values is evidence that the quadrupolar structure exists.

  1. The small size telescope projects for the Cherenkov Telescope Array

    CERN Document Server

    ,

    2015-01-01

    The small size telescopes (SSTs), spread over an area of several square km, dominate the CTA sensitivity in the photon energy range from a few TeV to over 100 TeV, enabling for the detailed exploration of the very high energy gamma-ray sky. The proposed telescopes are innovative designs providing a wide field of view. Two of them, the ASTRI (Astrophysics con Specchi a Tecnologia Replicante Italiana) and the GCT (Gamma-ray Cherenkov Telescope) telescopes, are based on dual mirror Schwarzschild-Couder optics, with primary mirror diameters of 4 m. The third, SST-1M, is a Davies-Cotton design with a 4 m diameter mirror. Progress with the construction and testing of prototypes of these telescopes is presented. The SST cameras use silicon photomultipliers, with preamplifier and readout/trigger electronics designed to optimize the performance of these sensors for (atmospheric) Cherenkov light. The status of the camera developments is discussed. The SST sub-array will consist of about 70 telescopes at the CTA souther...

  2. Lightweighted ZERODUR for telescopes

    Science.gov (United States)

    Westerhoff, T.; Davis, M.; Hartmann, P.; Hull, T.; Jedamzik, R.

    2014-07-01

    The glass ceramic ZERODUR® from SCHOTT has an excellent reputation as mirror blank material for earthbound and space telescope applications. It is known for its extremely low coefficient of thermal expansion (CTE) at room temperature and its excellent CTE homogeneity. Recent improvements in CNC machining at SCHOTT allow achieving extremely light weighted substrates up to 90% incorporating very thin ribs and face sheets. In 2012 new ZERODUR® grades EXPANSION CLASS 0 SPECIAL and EXTREME have been released that offer the tightest CTE grades ever. With ZERODUR® TAILORED it is even possible to offer ZERODUR® optimized for customer application temperature profiles. In 2013 SCHOTT started the development of a new dilatometer setup with the target to drive the industrial standard of high accuracy thermal expansion metrology to its limit. In recent years SCHOTT published several paper on improved bending strength of ZERODUR® and lifetime evaluation based on threshold values derived from 3 parameter Weibull distribution fitted to a multitude of stress data. ZERODUR® has been and is still being successfully used as mirror substrates for a large number of space missions. ZERODUR® was used for the secondary mirror in HST and for the Wolter mirrors in CHANDRA without any reported degradation of the optical image quality during the lifetime of the missions. Some years ago early studies on the compaction effects of electron radiation on ZERODUR® were re analyzed. Using a more relevant physical model based on a simplified bimetallic equation the expected deformation of samples exposed in laboratory and space could be predicted in a much more accurate way. The relevant ingredients for light weighted mirror substrates are discussed in this paper: substrate material with excellent homogeneity in its properties, sufficient bending strengths, space radiation hardness and CNC machining capabilities.

  3. Telescopic drilling rod

    Energy Technology Data Exchange (ETDEWEB)

    Kagan, I.L.; Berezov, S.I.; Gavrilov, G.A.; Goykhman, Ya.A.; Makushkin, D.O.; Rachev, M.P.; Voynich, L.K.

    1981-09-07

    The telescopic drilling rod includes an inner section of the rod, in whose center cable has been passed and is attached a bearing assembly connecting it to the winch, outer section of rod along which there is pipeline connecting the working cavity formed by the inner section of rod and the housing, installed on the lower end of the outer section of rod, with cavity formed by framework of the guide swivel and end piece and connected to the hydraulic system of the machine by pipeline, as well as clamping elements. In order to drill wells to a depth greater than the length of the outer sectrion of the rod, the latter jointly with the inner section of rod is lowered into the extreme lower position until swivel rests on the feed mechanism. With further slipping of cable and the absence of pressure in the hydraulic system, clamping elements do not have an effect on the inner section of rod. It has the opportunity to freely move along the outer section of rod downwards to the face. When pressure is supplied on pipeline into cavity and further through pipeline into working cavity, the inner section of rod is clamped with feed of the outer section in the process of drilling, both sections move jointly. Because of the link between working cavity of sleeve installed on the lower end of the outer section of rod, and the hydraulic system of the machine through the swivel cavity, it is possible to fix the drilling rod in any mutual axial position of the section.

  4. BCK Network of Optical Telescopes

    Science.gov (United States)

    McGruder, Charles H.; Antoniuk, Krill; Carini, Michael T.; Gelderman, Richard; Hammond, Benjamin; Hicks, Stacy; Laney, David; Shakhovskoy, David; Strolger, Louis-Gregory; Williams, Joshua

    2015-01-01

    The BCK network consists of three research grade telescopes: 0.6m (B) at the Bell Observatory near Western Kentucky University (WKU), 1.3m (C) at the Crimean Astrophysical Observatory and a 1.3m (K) at Kitt Peak National Observatory. The Bell Telescope is operated remotely from WKU while the Robotically Controlled Telescope (RCT) at Kitt Peak possesses an autonomous scheduler. The BCK telescopes are distributed longitudinally over 145º and can be used to observe continuously up to 21.2 hours/day. The network will be chiefly employed to observe variable stars, blazars and unpredictable celestial events.Because celestial objects with ground-based telescopes cannot be observed optically during the daytime, continuous ground-based astronomical observations are only possible via a network of longitudinally distributed telescopes. When the sun rises in Crimea after it sets at Bell, continuous observations are possible. This occurs for about six and ½ months per year - mid September to early April. A network is highly desirable for events that are not predictable for instance the appearance of supernovae, gamma-ray bursts, or undiscovered exoplanetsVariable stars are really only known in significant numbers to about 14 mag. But, as the magnitude increases the number of stars in any field increases very sharply, so there are many variable stars to discover at faint magnitude (m > 14). Discovering new variables makes great undergraduate student projects, a major component of astronomical research at WKU. In addition, pinning down the periods of variable stars is greatly facilitated with a network of telescopes.The BCK telescope network will also be used for monitoring the optical variability of blazars. The network provides increased coverage on daily variability timescales by minimizing interruptions due to weather and or mechanical problems at any one observatory and is used for obtaining continuous (12+ hours) of observations of rapid variability in blazars which would

  5. Hubble Space Telescope-Illustration

    Science.gov (United States)

    1989-01-01

    This illustration depicts a side view of the Hubble Space Telescope (HST). The HST is the product of a partnership between NASA, European Space Agency Contractors, and the international community of astronomers. It is named after Edwin P. Hubble, an American Astronomer who discovered the expanding nature of the universe and was the first to realize the true nature of galaxies. The purpose of the HST, the most complex and sensitive optical telescope ever made, is to study the cosmos from a low-Earth orbit. By placing the telescope in space, astronomers are able to collect data that is free of the Earth's atmosphere. The HST detects objects 25 times fainter than the dimmest objects seen from Earth and provides astronomers with an observable universe 250 times larger than visible from ground-based telescopes, perhaps as far away as 14 billion light-years. The HST views galaxies, stars, planets, comets, possibly other solar systems, and even unusual phenomena such as quasars, with 10 times the clarity of ground-based telescopes. The major elements of the HST are the Optical Telescope Assembly (OTA), the Support System Module (SSM), and the Scientific Instruments (SI). The HST is approximately the size of a railroad car, with two cylinders joined together and wrapped in a silvery reflective heat shield blanket. Wing-like solar arrays extend horizontally from each side of these cylinders, and dish-shaped anternas extend above and below the body of the telescope. The HST was deployed from the Space Shuttle Discovery (STS-31 mission) into Earth orbit in April 1990. The Marshall Space Flight Center had responsibility for design, development, and construction of the HST. The Perkin-Elmer Corporation, in Danbury, Connecticut, developed the optical system and guidance sensors. The Lockheed Missile and Space Company of Sunnyvale, California produced the protective outer shroud and spacecraft systems, and assembled and tested the finished telescope.

  6. The Large Binocular Telescope Project

    Science.gov (United States)

    Hill, J. M.

    1995-05-01

    The Large Binocular Telescope (LBT) Project has evolved from concepts first proposed in 1985. The present partners involved in the design and construction of this 2 x 8.4 meter binocular telescope are the University of Arizona, Italy represented by the Osservatorio Astrofisico di Arcetri and the Research Corporation based in Tucson. These three partners have committed sufficient funds to build the enclosure and the telescope populated with a single 8.4 meter optical train --- approximately 40 million dollars (1989). Based on this commitment, design and construction activities are now moving forward. Additional partners are being sought. The next mirror to be cast at the Steward Observatory Mirror Lab in spring of 1996 will be the first borosilicate honeycomb primary for LBT. The baseline optical configuration of LBT includes wide field Cassegrain secondaries with optical foci above the primaries to provide a corrected one degree field at F/4. The infrared F/15 secondaries are a Gregorian design to allow maximicrons flexibility for adaptive optics. The F/15 secondaries are undersized to provide a low thermal background focal plane which is unvignetted over a 4 arcminute diameter field-of-view. The interferometric focus combining the light from the two 8.4 meter primaries will reimage two folded Gregorian focal planes to a central location. The telescope elevation structure accommodates swing arms which allow rapid interchange of the various secondary and tertiary mirrors. Maximicrons stiffness and minimal thermal disturbance continue to be important drivers for the detailed design of the telescope. The telescope structure accommodates installation of a vacuum bell jar for aluminizing the primary mirrors in-situ on the telescope. The detailed design of the telescope structure will be completed in 1995 by ADS Italia (Lecco) and European Industrial Engineering (Mestre). The final enclosure design is now in progress at M3 Engineering (Tucson) and ADS Italia

  7. The calculus of telescopic urbanism

    OpenAIRE

    Arabindoo, P.

    2013-01-01

    Developing Amin's invocation of a telescopic urbanism as more than a visual metaphor, this paper seeks to rethink its epistemological and methodological focus, resisting at the same time the tendency to oversimplify the relationship between the different optics he outlines. Threatened by a dominant meta-narrative of a numerically driven calculus, this paper identifies an opportunity in Amin's telescopic urbanism to reject the 'big-data' approach to the city. In this context, it challenges the...

  8. The ASTRI prototype and mini-array: precursor telescopes for the Cherenkov Telescope Array

    Science.gov (United States)

    Pareschi, Giovanni

    2016-07-01

    In the framework of the Cherenkov Telescope Array (CTA) Observatory, the Italian National Institute of Astrophysics (INAF) has recently inaugurated in Sicily (Italy), at the Serra La Nave astronomical site on the slopes of Mount Etna, a large field of view (9.6 degrees) dual-mirror prototype (ASTRI SST-2M) of the CTA small size class of telescopes. CTA plans to install about 70 small size telescopes in the southern site to allow the study of the gamma rays from a few TeV up to hundreds of TeV. The ASTRI SST-2M telescope prototype has been developed following an end-to-end approach, since it includes the entire system of structure, mirror's optics (primary and secondary mirrors), camera, and control/acquisition software. Although it is a technological prototype, the ASTRI SST-2M prototype will be able to perform systematic monitoring of bright TeV sources. A remarkable improvement in terms of performance could come from the operation of the ASTRI mini-array, led by INAF in synergy with the Universidade de Sao Paulo (Brazil) and the North-West University (South Africa) and with also a contribution by INFN. The ASTRI mini-array will be composed of at least nine ASTRI SST-2M units. It is proposed as one of the CTA mini-array of telescope precursors and initial seeds of CTA, to be installed at the final CTA southern site. Apart from the assessment of a number of technological aspects related to CTA, the ASTRI mini-array will extend and improve the sensitivity, similar to the H.E.S.S. one in the 1-10 TeV energy range, up to about 100 TeV.

  9. Demonstration Telescopes Using "Dollar Optics"

    Science.gov (United States)

    Ross, Paul

    2008-05-01

    I propose a poster that illustrates the use of "dollar optics” for experimentation and for the creation of demonstration telescopes. Handling a variety of lenses and mirrors provides an opportunity for discovering practical optics. Some part of this path of exploration must have been traveled by Galileo as he experimented with spectacle lenses. "Dollar optics” include reading glasses (positive meniscus lenses), convex and concave mirrors, Fresnel sheets, magnifying lenses, and eye loupes. Unwanted distance spectacles (negative meniscus lenses) are available at second-hand stores. Galileo telescopes, "long” 17th century telescopes, and useful demonstration models of Newtonian reflectors can be made with "dollar” optics. The poster will illustrate practical information about "dollar optics” and telescopes: magnification, focal length, and "diopters” disassembling spectacles; creating cheap mounts for spectacle lenses; the importance of optical axes and alignment; eyepieces; and focusing. (A table would be useful with the poster to set out a hands-on display of "dollar optic” telescopes.) Educators, experimenters, and those concerned with astronomy outreach might be interested in this poster. Working with "dollar optics” requires facility with simple tools, interest in planning projects, patience, imagination, and the willingness to invest some time and effort. "Dollar optics” may help to foster creativity and hands-on enthusiasm - as did Galileo's work with simple lenses 400 years ago. "Oh! When will there be an end put to the new observations and discoveries of this admirable instrument?” - Galileo Galilei as quoted by Henry C. King, The History of the Telescope.

  10. The upgraded MAGIC Cherenkov telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Tescaro, D., E-mail: dtescaro@iac.es [Instituto de Astrofísica de Canarias (IAC), E-38205 La Laguna, Tenerife (Spain); Universidad de La Laguna (ULL), Dept. Astrofísica, E-38206 La Laguna, Tenerife (Spain)

    2014-12-01

    The MAGIC Cherenkov telescopes underwent a major upgrade in 2011 and 2012. A new 1039-pixel camera and a larger area digital trigger system were installed in MAGIC-I, making it essentially identical to the newer MAGIC-II telescope. The readout systems of both telescopes were also upgraded, with fully programmable receiver boards and DRS4-chip-based digitization systems. The upgrade eased the operation and maintenance of the telescopes and also improved significantly their performance. The system has now an integral sensitivity as good as 0.6% of the Crab Nebula flux (for E>400GeV), with an effective analysis threshold at 70 GeV. This allows MAGIC to secure one of the leading roles among the current major ground-based Imaging Atmospheric Cherenkov telescopes for the next 5–10 years. - Highlights: • In 2011 and 2012 the MAGIC telescopes underwent a two-stage major upgrade. • The new camera of MAGIC-I allows us to exploit a 1.4 larger trigger area. • The novel DRS4-based readout systems allow a cost-effective ultra-fast digitization. • The upgrade greatly improved the maintainability of the system. • MAGIC has now an optimal integral sensitivity of 0.6% of the Crab Nebula flux.

  11. SLAS Library Telescope Program (Abstract)

    Science.gov (United States)

    Small, J. S.

    2016-12-01

    (Abstract only) In the fall of 2014, I submitted to the members of the St. Louis Astronomical Society to take the $1,000 profit we had from a convention we had hosted and use it to purchase three telescopes to modify for a Library Telescope program that was invented by Mark Stowbridge and promoted by the New Hampshire Astronomical Society. I had met Mark at NEAF in 2012 when he was walking the floor demonstrating the telescope. We held meetings with three libraries, the St. Louis County Library system, the St. Louis Public Library system and an independent library in Kirkwood, Missouri. The response was overwhelming! SLCL responded with a request for ten telescopes and SLPL asked for five. We did our first build in October, 2014 and placed a total of eighteen telescopes. Since that time, SLAS has placed a total of eighty-eight telescopes in library systems around the St. Louis Metro area, expanding into neighboring counties and across the river in Illinois. In this talk, I will discuss how to approach this project and put it in place in your libraries!

  12. Concept Design for SOAR Telescope

    Science.gov (United States)

    Sebring, T.; Cecil, G.; Krabbendam, V.; Moretto, G.

    1998-12-01

    The Southern Astrophysical Research (SOAR) telescope is a \\$28M collaboration between Brazil, NOAO, Michigan State University, and the University of North Carolina at Chapel Hill. NOAO will operate the telescope for 20 years in exchange for 30 astronomers.) The project is now fully funded. This f/16 telescope is optimized for high-quality images across the isokinetic field (0."17 FWHM degradation from the telescope+facility over a field of 7.5' diameter.) It is being designed to take up to 2 Gemini-class (2100 kg) instruments, or a combination of lighter instruments at 7 Nasmyth and bent Cassegrain foci. The facility is now under construction atop Cerro Pachon, 400m from Gemini-S. First light is currently scheduled for early 2002. Corning Inc. is preparing to fabricate the 4.2m-diameter, 7.5-10 cm thick primary mirror from ULE glass. In early 1999 contacts will be awarded for 2 major subsystems: active optics (which includes optics polishing), and the alt.-az. telescope mount. We will outline the novel strategies that are being used to control project costs while optimizing telescope performance. Instrumentation plans will also be summarized.

  13. Cryogenic optical test planning using the Optical Telescope Element Simulator with the James Webb Space Telescope Integrated Science Instrument Module

    Science.gov (United States)

    Reichard, Timothy A.; Bond, Nicholas A.; Greeley, Bradford W.; Malumuth, Eliot M.; Melendez, Marcio; Shiri, Ron; Alves de Oliveira, Catarina; Antonille, Scott R.; Birkmann, Stephan; Davis, Clinton; Dixon, William V.; Martel, André R.; Miskey, Cherie L.; Ohl, Raymond G.; Sabatke, Derek; Sullivan, Joseph

    2016-09-01

    NASA's James Webb Space Telescope (JWST) is a 6.5 m diameter, segmented, deployable telescope for cryogenic infrared space astronomy ( 40 K). The JWST Observatory architecture includes the Optical Telescope Element (OTE) and the Integrated Science Instrument Module (ISIM) element that contains four science instruments (SIs), including a guider. The SI and guider units are integrated to the ISIM structure and optically tested at NASA Goddard Space Flight Center as an instrument suite using a telescope simulator (Optical Telescope Element SIMulator; OSIM). OSIM is a high-fidelity, cryogenic JWST telescope simulator that features a 1.5m diameter powered mirror. The SIs are aligned to the flight structure's coordinate system under ambient, clean room conditions using optomechanical metrology and customized interfaces. OSIM is aligned to the ISIM mechanical coordinate system at the cryogenic operating temperature via internal mechanisms and feedback from alignment sensors and metrology in six degrees of freedom. SI performance, including focus, pupil shear, pupil roll, boresight, wavefront error, and image quality, is evaluated at the operating temperature using OSIM. The comprehensive optical test plans include drafting OSIM source configurations for thousands of exposures ahead of the start of a cryogenic test campaign. We describe how we predicted the performance of OSIM light sources illuminating the ISIM detectors to aide in drafting these optical tests before a test campaign began. We also discuss the actual challenges and successes of those exposure predictions encountered during a test campaign to fulfill the demands of the ISIM optical performance verification.

  14. The next generation Cherenkov Telescope Array observatory: CTA

    Energy Technology Data Exchange (ETDEWEB)

    Vercellone, S., E-mail: stefano@ifc.inaf.it

    2014-12-01

    The Cherenkov Telescope Array (CTA) is a large collaborative effort aimed at the design and operation of an observatory dedicated to the very high-energy gamma-ray astrophysics in the energy range 30 GeV–100 TeV, which will improve by about one order of magnitude the sensitivity with respect to the current major arrays (H.E.S.S., MAGIC, and VERITAS). In order to achieve such improved performance, for both the northern and southern CTA sites, four units of 23 m diameter Large Size Telescopes (LSTs) will be deployed close to the centre of the array with telescopes separated by about 100 m. A larger number (about 25 units) of 12 m Medium Size Telescopes (MSTs, separated by about 150 m), will cover a larger area. The southern site will also include up to 24 Schwarzschild–Couder dual-mirror medium-size Telescopes (SCTs) with the primary mirror diameter of 9.5 m. Above a few TeV, the Cherenkov light intensity is such that showers can be detected even well outside the light pool by telescopes significantly smaller than the MSTs. To achieve the required sensitivity at high energies, a huge area on the ground needs to be covered by Small Size Telescopes (SSTs) with a field of view of about 10° and an angular resolution of about 0.2°, making the dual-mirror configuration very effective. The SST sub-array will be composed of 50–70 telescopes with a mirror area of about 5–10 m{sup 2} and about 300 m spacing, distributed across an area of about 10 km{sup 2}. In this presentation we will focus on the innovative solution for the optical design of the medium and small size telescopes based on a dual-mirror configuration. This layout will allow us to reduce the dimension and the weight of the camera at the focal plane of the telescope, to adopt Silicon-based photo-multipliers as light detectors thanks to the reduced plate-scale, and to have an optimal imaging resolution on a wide field of view.

  15. The next generation Cherenkov Telescope Array observatory: CTA

    Science.gov (United States)

    Vercellone, S.

    2014-12-01

    The Cherenkov Telescope Array (CTA) is a large collaborative effort aimed at the design and operation of an observatory dedicated to the very high-energy gamma-ray astrophysics in the energy range 30 GeV-100 TeV, which will improve by about one order of magnitude the sensitivity with respect to the current major arrays (H.E.S.S., MAGIC, and VERITAS). In order to achieve such improved performance, for both the northern and southern CTA sites, four units of 23 m diameter Large Size Telescopes (LSTs) will be deployed close to the centre of the array with telescopes separated by about 100 m. A larger number (about 25 units) of 12 m Medium Size Telescopes (MSTs, separated by about 150 m), will cover a larger area. The southern site will also include up to 24 Schwarzschild-Couder dual-mirror medium-size Telescopes (SCTs) with the primary mirror diameter of 9.5 m. Above a few TeV, the Cherenkov light intensity is such that showers can be detected even well outside the light pool by telescopes significantly smaller than the MSTs. To achieve the required sensitivity at high energies, a huge area on the ground needs to be covered by Small Size Telescopes (SSTs) with a field of view of about 10° and an angular resolution of about 0.2°, making the dual-mirror configuration very effective. The SST sub-array will be composed of 50-70 telescopes with a mirror area of about 5-10 m2 and about 300 m spacing, distributed across an area of about 10 km2. In this presentation we will focus on the innovative solution for the optical design of the medium and small size telescopes based on a dual-mirror configuration. This layout will allow us to reduce the dimension and the weight of the camera at the focal plane of the telescope, to adopt Silicon-based photo-multipliers as light detectors thanks to the reduced plate-scale, and to have an optimal imaging resolution on a wide field of view.

  16. Low-Maintenance Turfgrass Research at the USDA-ARS Forage and Range Research Laboratory in Logan, UT

    Science.gov (United States)

    The USDA-ARS Forage and Range Research Lab (FRRL) is located in Logan, UT, on the Utah State University campus. Although traditionally studying dryland grasses and legumes with an emphasis on forage production, low maintenance turfgrass research at the FRRL, has been underway since the early 1990's...

  17. 75 FR 74699 - Logan City, UT; Notice of Application Accepted for Filing and Soliciting Comments, Motions To...

    Science.gov (United States)

    2010-12-01

    ... Energy Regulatory Commission Logan City, UT; Notice of Application Accepted for Filing and Soliciting... filed: July 29, 2010, and supplemented on November 5, 2010. d. Applicant: Logan City, Utah. e. Name of... Project would be located on a flow control pipeline in Logan City's water distribution system located...

  18. La grossesse gémellaire sur un utérus pseudo unicorne: à propos d'un cas

    Science.gov (United States)

    aheri, Hafsa; Saadi, Hanane; Benkirane, Saad; Mimouni, Ahmed

    2015-01-01

    L'incidence des malformations utérines est estimée dans la population générale entre 0,1 et 3%. La survenue d'une grossesse en cas de malformation utérine est une situation potentiellement à haut risque obstétrical. Nous décrivons un cas très rare d'une grossesse gémellaire sur un utérus pseudo unicorne découverte précocement à 8 SA, permettant la réalisation d'une hémihysterectomie de la corne rudimentaire prévenant ainsi le risque majeur de la rupture utérine. L’évolution était favorable jusqu’à 37 SA où la patiente a été programmée pour césarienne prophylactique. Le dépistage échographique au premier trimestre de la grossesse est donc primordial permettant la détection systématique de ce genre de malformation afin de prévenir les complications. PMID:26977238

  19. Lack of association between urotensin-II (UTS2 gene polymorphisms (Thr21Met and Ser89Asn and migraine

    Directory of Open Access Journals (Sweden)

    Betül Ozan

    2017-07-01

    Full Text Available Migraine is a common neurovascular brain disorder with heterogeneous clinical presentation, including recurrent headache attacks. The pathophysiology of migraine is complex, and a number of genomic regions have been associated with the development of migraine. In this study, we analyzed the allele and genotype frequencies of the urotensin-II gene (UTS2 polymorphisms, Thr21Met and Ser89Asn, among Turkish patients with migraine. A total of 146 patients with migraine (14 with aura [MA group] and 132 without aura [MO group] were genotyped for Thr21Met and Ser89Asn polymorphisms and compared with 154 age- and sex-matched healthy controls. The UTS2 gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP. No significant differences were observed in allele and genotype frequencies for Thr21Met and Ser89Asn polymorphisms between the patients with migraine and control group. Similarly, we did not observe significant differences in allele and genotype frequencies between MA and MO and control group. Moreover, the haplotype analysis showed no association between UTS2 gene haplotypes (MN, MS, TN, and TS and migraine. In summary, Thr21Met and Ser89Asn polymorphisms of the UTS2 gene are not risk factors for migraine in our sample of Turkish migraine patients.

  20. 78 FR 6832 - Notice of Mailing Address Change for the Utah State Office, Salt Lake City, UT

    Science.gov (United States)

    2013-01-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Land Management Notice of Mailing Address Change for the Utah State Office, Salt Lake City, UT AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: The mailing address for the...

  1. 77 FR 13074 - Opportunity for Designation in the Pocatello, ID; Evansville, IN; and Salt Lake City, UT Areas...

    Science.gov (United States)

    2012-03-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Grain Inspection, Packers and Stockyards Administration Opportunity for Designation in the Pocatello, ID; Evansville, IN; and Salt Lake City, UT Areas; Request for Comments on the Official Agencies Servicing...

  2. 75 FR 26788 - Public Land Order No. 7742; Withdrawal of Public Land for the Manning Canyon Tailings Repository; UT

    Science.gov (United States)

    2010-05-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Land Management Public Land Order No. 7742; Withdrawal of Public Land for the Manning Canyon Tailings Repository; UT AGENCY: Bureau of Land Management, Interior. ACTION: Public Land Order....

  3. 75 FR 15458 - Request for Small Reclamation Projects Act Loan To Construct Narrows Dam in Sanpete County, UT

    Science.gov (United States)

    2010-03-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Bureau of Reclamation Request for Small Reclamation Projects Act Loan To Construct Narrows Dam in Sanpete County, UT AGENCY: Bureau of Reclamation, Interior. ACTION: Notice of Availability and Notice of...

  4. The Research Productivity of Small Telescopes and Space Telescopes

    CERN Document Server

    Ringwald, F A; Lovell, R L; Kays, S A; Torres, Y V A

    2003-01-01

    We present statistics on the research productivity of astronomical telescopes. These were compiled by finding papers in which new data were presented, noting which telescopes were used, and then counting the number of papers, number of pages, and other statistics. The journals used were the Astronomical Journal, the Astrophysical Journal (including the Letters and Supplements), and the Publications of the Astronomical Society of the Pacific. We also compiled citations from the Science Citation Index. This work was designed to be similar to that of Trimble (1995), except that more recent journals (from 1995) and citations (from 1998) were used. We also did not restrict our sample to large telescopes only: we included all telescopes from which new data were presented, the smallest of which was a 0.1-m. The data were gathered by first-year work-study undergraduates, who were instructed to include data for all telescopes for which they found new data were included in the journals. A by-product of this research wa...

  5. Response of the Earth system to zonal tidal forcing examined by VLBI based dUT1 variations

    Science.gov (United States)

    Boehm, S.; Schuh, H.

    2011-10-01

    The VLBI group at the Institute of Geodesy and Geophysics of Vienna University of Technology is developing the software VieVS (Vienna VLBI software) for the analysis of geodetic VLBI data. VieVS incorporates the most recent models recommended by the IERS Conventions and in contrast to other VLBI software uses a parameterization with piece-wise linear offsets at integer hours. Thus it provides more flexibility for combination or comparison with time series from other space geodetic techniques or of geophysical origin. We employed this new software to re-process all available geodetic VLBI sessions from 1984 till 2010, suitable for the determination of the Earth rotation parameters (ERP), i.e. dUT1 (UT1-UTC) and the polar motion coordinates xp and yp. Zonal tidal signals with periods from 5 to 35 days in the derived dUT1 long-time series were then used to estimate the so-called zonal response coefficient κ defined by Agnew and Farrell (1978). The frequency dependent zonal response coefficient is an extension to the concept of the Love number k2 which allows for a response of the Earth to tidal forcing, deviating from purely elastic behaviour and thus taking into account effects of ocean tides, a fluid core and mantle anelasticity. A tidally induced change of the rotation rate of the Earth and consequently of dUT1 is proportional to the tide-generating potential through the zonal response coefficient κ. The values estimated for κ for different tidal frequencies from VLBI observations of dUT1 were compared to theory and to the results of previous determinations of κ from observations of space geodetic techniques.

  6. Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with pulmonary arterial hypertension.

    Science.gov (United States)

    Bowles, Elizabeth A; Moody, Gina N; Yeragunta, Yashaswini; Stephenson, Alan H; Ellsworth, Mary L; Sprague, Randy S

    2015-01-01

    Both prostacyclin analogs and phosphodiesterase 5 (PDE5) inhibitors are effective treatments for pulmonary arterial hypertension (PAH). In addition to direct effects on vascular smooth muscle, prostacyclin analogs increase cAMP levels and ATP release from healthy human erythrocytes. We hypothesized that UT-15C, an orally available form of the prostacyclin analog, treprostinil, would stimulate ATP release from erythrocytes of humans with PAH and that this release would be augmented by PDE5 inhibitors. Erythrocytes were isolated and the effect of UT-15C on cAMP levels and ATP release were measured in the presence and absence of the PDE5 inhibitors, zaprinast or tadalafil. In addition, the ability of a soluble guanylyl cyclase inhibitor to prevent the effects of tadalafil was determined. Erythrocytes of healthy humans and humans with PAH respond to UT-15C with increases in cAMP levels and ATP release. In both groups, UT-15C-induced ATP release was potentiated by zaprinast and tadalafil. The effect of tadalafil was prevented by pre-treatment with an inhibitor of soluble guanylyl cyclase in healthy human erythrocytes. Importantly, UT-15C-induced ATP release was greater in PAH erythrocytes than in healthy human erythrocytes in both the presence and the absence of PDE5 inhibitors. The finding that prostacyclin analogs and PDE5 inhibitors work synergistically to enhance release of the potent vasodilator ATP from PAH erythrocytes provides a new rationale for the co-administration of these drugs in this disease. Moreover, these results suggest that the erythrocyte is a novel target for future drug development for the treatment of PAH.

  7. VISTA: Pioneering New Survey Telescope Starts Work

    Science.gov (United States)

    2009-12-01

    A new telescope - VISTA (the Visible and Infrared Survey Telescope for Astronomy) - has just started work at ESO's Paranal Observatory and has made its first release of pictures. VISTA is a survey telescope working at infrared wavelengths and is the world's largest telescope dedicated to mapping the sky. Its large mirror, wide field of view and very sensitive detectors will reveal a completely new view of the southern sky. Spectacular new images of the Flame Nebula, the centre of our Milky Way galaxy and the Fornax Galaxy Cluster show that it is working extremely well. VISTA is the latest telescope to be added to ESO's Paranal Observatory in the Atacama Desert of northern Chile. It is housed on the peak adjacent to the one hosting the ESO Very Large Telescope (VLT) and shares the same exceptional observing conditions. VISTA's main mirror is 4.1 metres across and is the most highly curved mirror of this size and quality ever made - its deviations from a perfect surface are less than a few thousandths of the thickness of a human hair - and its construction and polishing presented formidable challenges. VISTA was conceived and developed by a consortium of 18 universities in the United Kingdom [1] led by Queen Mary, University of London and became an in-kind contribution to ESO as part of the UK's accession agreement. The telescope design and construction were project-managed by the Science and Technology Facilities Council's UK Astronomy Technology Centre (STFC, UK ATC). Provisional acceptance of VISTA was formally granted by ESO at a ceremony at ESO's Headquarters in Garching, Germany, attended by representatives of Queen Mary, University of London and STFC, on 10 December 2009 and the telescope will now be operated by ESO. "VISTA is a unique addition to ESO's observatory on Cerro Paranal. It will play a pioneering role in surveying the southern sky at infrared wavelengths and will find many interesting targets for further study by the Very Large Telescope, ALMA and

  8. Schwarzschild-Couder Telescope for the Cherenkov Telescope Array

    CERN Document Server

    Meagher, Kevin J

    2014-01-01

    The Cherenkov Telescope Array (CTA) is the next major ground-based observatory for gamma-ray astronomy. With CTA gamma-ray sources will be studied in the very-high energy gamma-ray range of a few tens of GeV to 100 TeV with up to ten times better sensitivity than available with current generation instruments. We discuss the proposed US contribution to CTA that comprises imaging atmospheric Cherenkov telescope with Schwarzschild-Couder (SC) optics. Key features of the SC telescope are a wide field of view of eight degrees, a finely pixelated camera with silicon photomultipliers as photon detectors, and a compact and power efficient 1 GS/s readout. The progress in both the optical system and camera development are discussed in this paper.

  9. GSMT Education: Teaching about Adaptive Optics and Site Selection Using Extremely Large Telescopes

    Science.gov (United States)

    Sparks, R. T.; Pompea, S. M.

    2010-08-01

    Giant Segmented Mirror Telescopes (GSMT) represents the next generation of extremely large telescopes (ELT). Currently there are three active ELT projects, all established as international partnerships to build telescopes of greater than 20 meters aperture. Two of these have major participation by U.S. institutions: the Giant Magellan Telescope and the Thirty Meter Telescope. The ESO-ELT is under development by the European Southern Observatory and other European institutions. We have developed educational activities to accompany the design phase of these projects. The current activities focus on challenges faced in the design and site selection of a large telescope. The first module is on site selection. This online module is based on the successful Astronomy Village program model. Students evaluate several potential sites to decide where to build the GSMT. They must consider factors such as weather, light pollution, seeing, logistics, and geography. The second project has developed adaptive optics teaching units suitable for high school.

  10. Project Management Plan/Progress Report UT/GTKS Training Program Development for Commercial Building Operators

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2013-03-31

    Universidad del Turabo (UT), in a collaborative effort with Global Turn Key Services, Inc. (GTKS), proposed to develop a training program and a commercialization plan for the development of Commercial Building Operators (CBOs). The CBOs will operate energy efficient buildings to help maintain existing buildings up to their optimal energy performance level, and ensure that net-zero-energy buildings continuously operate at design specifications, thus helping achieve progress towards meeting BTP Strategic Goals of creating technologies and design approaches that enable net-zero-energy buildings at low incremental costs by 2025. The proposed objectives were then: (1) Develop a Commercial Building Operator (CBO) training program and accreditation that will in turn provide a certification to participants recognized by Accreditation Boards such as the North American Board of Certified Energy Practitioners (NABCEP) and Leadership in Energy & Environmental Designs (LEED). (2) Develop and implement a commercialization and sustainability plan that details marketing, deployment, financial characterization, job placement, and other goals required for long-term sustainability of the project after the funding period. (3) After program development and deployment, provide potential candidates with the knowledge and skill sets to obtain employment in the commercial building green energy (net-zero-energy building) job market. The developed CBO training program will focus on providing skills for participants, such as displaced and unemployed workers, to enter the commercial building green energy (net-zeroenergy building) job market. This course was designed to allow a participant with minimal to no experience in commercial building green technology to obtain the required skill sets to enter the job market in as little as 12 weeks of intensive multi-faceted learning. After completion of the course, the CBO staff concluded the participant will meet minimum established accreditation

  11. Etude des facteurs de risque du retard de croissance intra-utérin à Lubumbashi

    Science.gov (United States)

    Moyambe, Jules Ngwe Thaba; Bernard, Pierre; Khang'Mate, Faustin; Nkoy, Albert Mwembo Tambwe A; Mukalenge, Faustin Chenge; Makanda, Daudet; Twite, Eugene; Ndudula, Arthur Munkana; Lubamba, Cham; Kadingi, Arnauld Kabulu; Kayomb, Mutach; Kayamba, Prosper Kalenga Muenze

    2013-01-01

    Introduction Dans notre milieu, il n'existe aucune politique de prévention du Retard de Croissance Intra-Utérin (RCIU) clairement défini. L'objectif de ce travail était d'identifier les facteurs de risque de RCIU afin de proposer une stratégie de lutte contre cette pathologie en agissant surtout sur des facteurs pouvant faire l'objet d'une action préventive. Méthodes Une étude cas-témoins a été menée dans 11 centres hospitaliers de Lubumbashi en République Démocratique du Congo, de Janvier 2010 à Juin 2011, dans le but d'identifier les facteurs de risque du retard de croissance intra-utérin (RCIU). Au total 420 gestantes (cas et témoins) avec grossesse monofoetale d'au moins 24 semaines d'aménorrhée ont été inclues dans l'étude. Les cas correspondaient aux gestantes dont le poids du fœtus était resté inférieur au 10 eme percentile des courbes de référence d'Alexander, après 2 échographies successives réalisées à intervalle de 4 semaines. Les témoins correspondaient aux gestantes dont le poids du fœtus était supérieur ou égal au 10 eme percentile de mêmes courbes. A chaque cas a été apparié un témoin de même parité porteur d'une grossesse de même âge. Résultats L'analyse univariée a identifié comme facteurs de risque: la taille maternelle. Conclusion L'amélioration du niveau socio-économique des populations, la lutte contre le paludisme et les consultations prénatales mieux organisées couplées à une meilleure éducation sanitaire et nutritionnelle peuvent contribuer sensiblement à la réduction de la fréquence du RCIU à Lubumbashi. PMID:23504392

  12. Feature-based telescope scheduler

    Science.gov (United States)

    Naghib, Elahesadat; Vanderbei, Robert J.; Stubbs, Christopher

    2016-07-01

    Feature-based Scheduler offers a sequencing strategy for ground-based telescopes. This scheduler is designed in the framework of Markovian Decision Process (MDP), and consists of a sub-linear online controller, and an offline supervisory control-optimizer. Online control law is computed at the moment of decision for the next visit, and the supervisory optimizer trains the controller by simulation data. Choice of the Differential Evolution (DE) optimizer, and introducing a reduced state space of the telescope system, offer an efficient and parallelizable optimization algorithm. In this study, we applied the proposed scheduler to the problem of Large Synoptic Survey Telescope (LSST). Preliminary results for a simplified model of LSST is promising in terms of both optimality, and computational cost.

  13. Scientific management of Space Telescope

    Science.gov (United States)

    Odell, C. R.

    1981-01-01

    A historical summay is given on the science management of the Space Telescope, the inception of which began in 1962, when scientists and engineers first recommended the development of a nearly diffraction limited substantial-size optical telescope. Phase A, the feasibility requirements generation phase, began in 1971 and consisted largely of NASA scientists and a NASA design. Phase B, the preliminary design phase, established a tiered structure of scientists, led by the Large Space Telescope operations and Management Work Group. A Mission Operations Working Group headed six instrument definition teams to develop the essential instrument definitions. Many changes took place during Phase B, before design and development, which began in 1978 and still continues today.

  14. FAMOUS. The fluorescence telescope prototype

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, Johannes; Bretz, Thomas; Hebbeker, Thomas; Lauscher, Markus; Middendorf, Lukas; Niggemann, Tim; Peters, Christine; Sommer, Dominik; Stephan, Maurice [III. Physikalisches Institut A, RWTH Aachen University (Germany); Auffenberg, Jan; Schaufel, Merlin [III. Physikalisches Institut B, RWTH Aachen University (Germany)

    2015-07-01

    One of the most successful techniques for the detection of air showers produced by ultra-high-energy cosmic rays are fluorescence telescopes. The light produced by de-exciting nitrogen in the atmosphere is typically detected by photomultiplier tubes (PMTs). This technique has been successfully used by the Pierre Auger Observatory in Argentina for many years. Silicon photomultipliers (SiPMs) promise higher photon detection efficiencies than PMTs. This and other advantages motivate the construction of the fluorescence telescope prototype FAMOUS (First Auger Multi-pixel photon counter camera for the Observation of Ultra-high-energy air Showers) which makes use of SiPMs. In this talk we discuss the FAMOUS telescope with a new 64-pixel camera including power supply and DAQ.

  15. LSST telescope and site status

    Science.gov (United States)

    Gressler, William J.

    2016-07-01

    The Large Synoptic Survey Telescope (LSST) Project1 received its construction authorization from the National Science Foundation in August 2014. The Telescope and Site (T and S) group has made considerable progress towards completion in subsystems required to support the scope of the LSST science mission. The LSST goal is to conduct a wide, fast, deep survey via a 3-mirror wide field of view optical design, a 3.2-Gpixel camera, and an automated data processing system. The summit facility is currently under construction on Cerro Pachón in Chile, with major vendor subsystem deliveries and integration planned over the next several years. This paper summarizes the status of the activities of the T and S group, tasked with design, analysis, and construction of the summit and base facilities and infrastructure necessary to control the survey, capture the light, and calibrate the data. All major telescope work package procurements have been awarded to vendors and are in varying stages of design and fabrication maturity and completion. The unique M1M3 primary/tertiary mirror polishing effort is completed and the mirror now resides in storage waiting future testing. Significant progress has been achieved on all the major telescope subsystems including the summit facility, telescope mount assembly, dome, hexapod and rotator systems, coating plant, base facility, and the calibration telescope. In parallel, in-house efforts including the software needed to control the observatory such as the scheduler and the active optics control, have also seen substantial advancement. The progress and status of these subsystems and future LSST plans during this construction phase are presented.

  16. The growth relationships in maiden trees of sour cherry ‘Łutówka’

    Directory of Open Access Journals (Sweden)

    Janusz Lipecki

    2015-10-01

    Full Text Available The studies were conducted in a nursery of sour cherry ‘Łutówka’ budded on Prunus mahaleb L. in the years 1993, 2000–2003, and 2013. The height of trees, the diameter of stems, and the length of lateral shoots were measured. The air temperature and precipitation higher than the long-term mean (by approximately 10 % and 28%, respectively contributed to the increase in the stem diameter, the total length of shoots, and the number of shoots per tree. The length of lateral shoots increased from the top of the crown towards the lower parts, however, the number of feathers per tree and the mean length of shoots decreased. A strong positive relationship (r = 0.74, P < 0.05 was revealed between the stem diameter and the total length of shoots. Generally, the correlations between the type of growth of sour cherry maiden trees and morphological traits were similar to those characteristic for apple maiden trees or “knip-boom” type trees.

  17. Development and test of the CO2 evaporative cooling system for the LHCb UT Detector

    CERN Multimedia

    Coelli, Simone

    2016-01-01

    The upgrade of the LHCb detector, which will take place during the Long Shutdown 2 from mid 2018 to the end of 2019, will extend significantly the physics reach of the experiment by allowing it to run at higher instantaneous luminosity with increased trigger efficiency for a wide range of decay channels. The LHCb upgrade relies on two major changes. Firstly, the full read-out of the front-end electronics, currently limited by a Level-0 trigger to 1 MHz, will be replaced with a 40 MHz trigger system. Secondly, the upgraded LHCb detector will be designed to cope with an increase of the nominal operational luminosity by a factor five compared to the current detector. Compared to the current experiment several subsystems need to be partially rebuilt. Among these the 4 TT planes will be replaced by new high granularity silicon micro-strip planes with an improved coverage of the LHCb acceptance.The new system is called the Upstream Tracker. The radiation length of each UT plane should not exceed the value of 1 % X0...

  18. Shame and guilt in the aftermath of terror: the Utøya Island study.

    Science.gov (United States)

    Aakvaag, Helene Flood; Thoresen, Siri; Wentzel-Larsen, Tore; Røysamb, Espen; Dyb, Grete

    2014-10-01

    In recent years, there has been increased interest in trauma-related shame and guilt and their relationship to mental health. Little is known, however, about shame and guilt following mass traumas, such as terrorism. This study investigates the potential associations of trauma-related shame and guilt with posttraumatic stress (PTS) reactions after the terrorist attack of July 22, 2011 on Utøya Island in Norway. Interviews were conducted with 325 of the 490 survivors 4 to 5 months after the event. Multiple linear regression analyses were employed to investigate associations. In the month previous to the interview, 44.1% (n = 143) of participants had experienced at least some guilt for what happened during the attack, and 30.5% (n = 99) had experienced at least some shame. Shame and guilt were both uniquely associated with PTS reactions after adjusting for terror exposure, gender, and other potential confounders (frequent shame: B = 0.54, frequent guilt: B = 0.33). We concluded that trauma-related shame and guilt are related to mental health after mass trauma.

  19. Experimental results from CEM-UTS single shot 9 mj railgun

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, R.J.; Zowarka, R.C. (Texas Univ., Austin, TX (United States). Center for Electromechanics)

    1991-01-01

    The Center for Electromechanics at the University of Texas at Austin (CEM-UT) has designed and fabricated a 10-m long 90 mm bore railgun. During the test program, a number of solid armatures and projectile packages have been tested in a 50 m deep vertical test range. The experiments are powered by six homopolar generator (HPG) charged inductive stores, sequentially staged to provide the desired acceleration profile. Prior to testing, computer simulations are run to determine the preferred current profile and predict system performance. During projectile flight, high speed films, x-rays, muzzle volts, and velocity/acceleration profiles are recorded along with power supply operating parameters. Postshot diagnostics include bore wear analysis and armature and target recovery. Comparisons of predicted and recorded shot performance are also made. On selected tests, an energy balance is performed to determine efficiencies of the various system components. In this paper, a summary of all 90 mm gun shots is presented along with critical data collected from selected tests.

  20. The CEM-UT rapid fire compulsator railgun system; Recent performance and development milestones

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, D.E.; Pratap, S.B.; Spann, M.L.; Thelen, R.F.; Werst, M.D. (Texas Univ., Austin, TX (United States). Center for Electromechanics)

    1991-01-01

    A test program for the rapid fire compensated pulsed alternator (compulsator) railgun system at the Center for Electromechanics at The University of Texas at Austin (CEM-UT) commenced in April 1986. Two years later, performance data generated in the period from the start of testing to December 1987 was presented at the 4th Symposium on Electromagnetic Launch Technology in Austin, TX. Since that time, 27 compulsator powered railgun experiments have been performed including a 1.0-MJ discharge at 3,510 rpm. In this test, a 724 kA current pulse accelerated an 80 g, aluminum armature to 2.05 km/s, thus exceeding the projectile velocity goal at 73% rated machine speed. Furthermore, operation with a single gun barrel has been achieved using a parallel path, solid-state closing switch to deliver 132 kA to the railgun injector. This paper presents data from the rapid fire compulsator railgun facility. Included is a discussion of the energy transfer, power output, and system efficiency during a 1.0 MJ discharge. Also shown are the injector current, voltage, and di/dt curves for this test which were used in the design of the solid-state closing switch. Results of railgun experiments using the solid-state switch are analyzed.

  1. The largest white light flare ever observed: 25 April 1984, 0001 UT

    Science.gov (United States)

    Neidig, D. F.; Grosser, H.; Kiplinger, A. L.

    1987-01-01

    The X13/3B flare of 25 April 1984, 0001 UT, was accompanied by intense white light emission that reached a peak power output approx 2x10 to the 29 erg/sec in the optical/near UV continuum; the total energy radiated in the continuum alone reached 10 to the 32 power ergs. This was the most powerful white light flare yet recorded, exceeding the peak output of the largest previously known event by more than one order of magnitude. The flare was a two-ribbon type with intense embedded kernels as observed in both Balmer-alpha line and Balmer continuum, and each of these flare ribbons covered separate umbrae shortly after the maximum of the event. The onset and peak of the white light emission coincided with the onset and peak of the associated E greater than 100 KeV hard X-ray burst, while the 1-8 angstrom soft X-ray emission reached its maximum 4 minutes after the peak in white light.

  2. LISA telescope spacer design investigations

    Science.gov (United States)

    Sanjuan, Josep; Mueller, Guido; Livas, Jeffrey; Preston, Alix; Arsenovic, Petar; Castellucci, Kevin; Generie, Joseph; Howard, Joseph; Stebbins, Robin

    The Laser Interferometer Space Antenna (LISA) is a space-based gravitational wave observa-tory with the goal of observing Gravitational Waves (GWs) from astronomical sources in a frequency range from 30 µHz to 0.1 Hz. The detection of GWs at such low frequency requires measurements of distances at the pico-meter level between bodies separated by 5 million kilo-meters. The LISA mission consists of three identical spacecraft (SC) separated by 5 × 106 km forming an equilateral triangle. Each SC contains two optical assemblies and two vacuum en-closures housing one proof mass (PM) in geodesic (free fall) motion each. The two assemblies on one SC are each pointing towards an identical assembly on each of the other two SC to form a non-equal arm interferometer. The measurement of the GW strain is done by measuring the change in the length of the optical path between the PMs of one arm relative to the other arms caused by the pass of a GW. An important element of the Interferometric Measurement System (IMS) is the telescope which, on one hand, gathers the light coming from the far SC (˜100 pW) and, on the other hand, expands and collimates the small outgoing beam ( 1 W) and sends it to the far SC. Due to the very demanding sensitivity requirements care must be taken in the design and validation of the telescope not to degrade the IMS performance. For instance, the diameter of the telescope sets the the shot noise of the IMS and depends critically on the diameter of the primary and the divergence angle of the outgoing beam. As the telescope is rather fast telescope, the divergence angle is a critical function of the overall separation between the primary and secondary. Any long term changes of the distance of more than a a few micro-meter would be detrimental to the LISA mission. Similarly challenging are the requirements on the in-band path-length noise for the telescope which has to be kept below 1 pm Hz-1/2 in the LISA band. Different configurations (on-axis/off axis

  3. The network of INTA telescopes

    Science.gov (United States)

    Cuesta, L.

    2008-06-01

    The Spanish Instituto Nacional de Técnica Aeroespacial has a network of three telescopes located at some of the best places for astronomy in mainland Spain. The first is at the Observatorio de Calar Alto in Almeria, at an altitude of more than 2100 m. The second is near Calatayud in Zaragoza, at the summit of a 1400-m high mountain. The last is on the campus of the Instituto Nacional de Técnica Aerospatial (INTA), in Madrid. The three telescopes are either 40 or 50 cm in diameter and will be available for communications and educational projects.

  4. Wide field of view telescope

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, Mark R. (Albuquerque, NM); McGraw, John T. (Placitas, NM); Zimmer, Peter C. (Albuquerque, NM)

    2008-01-15

    A wide field of view telescope having two concave and two convex reflective surfaces, each with an aspheric surface contour, has a flat focal plane array. Each of the primary, secondary, tertiary, and quaternary reflective surfaces are rotationally symmetric about the optical axis. The combination of the reflective surfaces results in a wide field of view in the range of approximately 3.8.degree. to approximately 6.5.degree.. The length of the telescope along the optical axis is approximately equal to or less than the diameter of the largest of the reflective surfaces.

  5. Superconductor lunar telescopes --Abstract only

    Science.gov (United States)

    Chen, P. C.; Pitts, R.; Shore, S.; Oliversen, R.; Stolarik, J.; Segal, K.; Hojaji, H.

    1994-01-01

    We propose a new type of telescope designed specifically for the lunar environment of high vacuum and low temperature. Large area UV-Visible-IR telescope arrays can be built with ultra-light-weight replica optics. High T(sub c) superconductors provide support, steering, and positioning. Advantages of this approach are light-weight payload compatible with existing launch vehicles, configurable large area optical arrays, no excavation or heavy construction, and frictionless electronically controlled mechanisms. We have built a prototype and will be demonstarting some of its working characteristics.

  6. Highlights from the Telescope Array

    Science.gov (United States)

    Matthews, J. N.

    2016-11-01

    The Telescope Array measures the properties of ultra high energy cosmic ray induced extensive air showers. We do this using a variety of techniques including an array of scintillator detectors to sample the footprint of the air shower when it reaches the Earth's surface and telescopes to measure the fluorescence and Cerenkov light of the air shower. From this we determine the energy spectrum and chemical composition of the primary particles. We also search for sources of cosmic rays and anisotropy. We have found evidence of a possible source of ultra high energy cosmic rays in the northern sky. The experiment and its most recent measurements will be discussed.

  7. Autonomous Dome for Robotic Telescope

    CERN Document Server

    Kumar, Akash; Ganesh, Shashikiran

    2016-01-01

    Physical Research Laboratory operates a 50cm robotic observatory at Mount Abu. This Automated Telescope for Variability Studies (ATVS) makes use of Remote Telescope System 2 (RTS2) for autonomous operations. The observatory uses a 3.5m dome from Sirius Observatories. We have developed electronics using Arduino electronic circuit boards with home grown logic and software to control the dome operations. We are in the process of completing the drivers to link our Arduino based dome controller with RTS2. This document is a short description of the various phases of the development and their integration to achieve the required objective.

  8. The Advanced Telescope for High Energy Astrophysics

    Science.gov (United States)

    Guainazzi, Matteo

    2017-08-01

    Athena (the Advanced Telescope for High Energy Astrophysics) is a next generation X-ray observatory currently under study by ESA for launch in 2028. Athena is designed to address the Hot and Energetic Universe science theme, which addresses two key questions: 1) How did ordinary matter evolve into the large scale structures we see today? 2) How do black holes grow and shape the Universe. To address these topics Athena employs an innovative X-ray telescope based on Silicon Pore Optics technology to deliver extremely light weight and high throughput, while retaining excellent angular resolution. The mirror can be adjusted to focus onto one of two focal place instruments: the X-ray Integral Field Unit (X-IFU) which provides spatially-resolved, high resolution spectroscopy, and the Wide Field Imager (WFI) which provides spectral imaging over a large field of view, as well as high time resolution and count rate tolerance. Athena is currently in Phase A and the study status will be reviewed, along with the scientific motivations behind the mission.

  9. The Zadko Telescope: Exploring the Transient Universe

    Science.gov (United States)

    Coward, D. M.; Gendre, B.; Tanga, P.; Turpin, D.; Zadko, J.; Dodson, R.; Devogéle, M.; Howell, E. J.; Kennewell, J. A.; Boër, M.; Klotz, A.; Dornic, D.; Moore, J. A.; Heary, A.

    2017-01-01

    The Zadko telescope is a 1 m f/4 Cassegrain telescope, situated in the state of Western Australia about 80-km north of Perth. The facility plays a niche role in Australian astronomy, as it is the only meter class facility in Australia dedicated to automated follow-up imaging of alerts or triggers received from different external instruments/detectors spanning the entire electromagnetic spectrum. Furthermore, the location of the facility at a longitude not covered by other meter class facilities provides an important resource for time critical projects. This paper reviews the status of the Zadko facility and science projects since it began robotic operations in March 2010. We report on major upgrades to the infrastructure and equipment (2012-2014) that has resulted in significantly improved robotic operations. Second, we review the core science projects, which include automated rapid follow-up of gamma ray burst (GRB) optical afterglows, imaging of neutrino counterpart candidates from the ANTARES neutrino observatory, photometry of rare (Barbarian) asteroids, supernovae searches in nearby galaxies. Finally, we discuss participation in newly commencing international projects, including the optical follow-up of gravitational wave (GW) candidates from the United States and European GW observatory network and present first tests for very low latency follow-up of fast radio bursts. In the context of these projects, we outline plans for a future upgrade that will optimise the facility for alert triggered imaging from the radio, optical, high-energy, neutrino, and GW bands.

  10. New telescope designs suitable for massively-multiplexed spectroscopy

    CERN Document Server

    Pasquini, L; Ellis, R; de Zeeuw, T

    2016-01-01

    We present two novel designs for a telescope suitable for massively-multiplexed spectroscopy. The first is a very wide field Cassegrain telescope optimised for fibre feeding. It provides a Field Of View (FOV) of 2.5 degrees diameter with a 10m primary mirror. It is telecentric and works at F/3, optimal for fibre injection. As an option, a gravity invariant focus for the central 10 arc-minutes can be added, to host, for instance, a giant integral field unit (IFU). It has acceptable performance in the 360-1300 nm wavelength range. The second concept is an innovative five mirror telescope design based on a Three Mirror Anastigmatic (TMA) concept. The design provides a large FOV in a convenient, gravity- invariant focal plane, and is scalable to a range of telescope diameters. As specific example, we present a 10m telescope with a 1.5 degree diameter FOV and a relay system that allows simultaneous spectroscopy with 10,000 mini-IFUs over a square degree, or, alternatively a 17.5 square arcminutes giant IFU, by usi...

  11. Results from the AMANDA telescope

    Energy Technology Data Exchange (ETDEWEB)

    Ahrens, J.; Bai, X.; Barwick, S.W.; Becka, T.; Becker, K.-H.; Bernardini, E.; Bertrand, D.; Binon, F.; Biron, A.; Boeser, S.; Botner, O.; Bouhali, O.; Burgess, T.; Carius, S.; Castermans, T.; Chirkin, D.; Conrad, J.; Cooley, J.; Cowen, D.F.; Davour, A.; De Clercq, C.; DeYoung, T.; Desiati, P.; Dewulf, J.-P.; Ekstroem, P.; Feser, T.; Gaisser, T.K.; Ganupati, R.; Gaug, M.; Geenen, H.; Gerhardt, L.; Goldschmidt, A.; Hallgren, A.; Halzen, F.; Hanson, K.; Hardtke, R.; Hauschildt, T.; Hellwig, M.; Herquet, Ph.; Hill, G.C.; Hulth, P.O.; Hultqvist, K.; Hundertmark, S.; Jacobsen, J.; Karle, A.; Koepke, L.; Kuehn, K.; Kowalski, M.; Lamoureux, J.I.; Leich, H.; Leuthold, M.; Lindahl, P.; Liubarsky, I.; Madsen, J.; Mandli, K.; Marciniewski, P.; Matis, H.S.; McParland, C.P.; Messarius, T.; Minaeva, Y.; Miocinovic, P.; Morse, R.; Nahnhauer, R.; Neunhoeffer, T.; Niessen, P.; Nygren, D.R.; Ogelman, H.; Olbrechts, Ph.; Perez de los Heros, C.; Pohl, A.C.; Price, P.B.; Przybylski, G.T.; Rawlins, K.; Resconi, E.; Rhode, W.; Ribordy, M.; Richter, S.; Rodriguez Martino, J.; Sander, H.-G.; Schmidt, T.; Schneider, D.; Schinarakis, K.; Schwarz, R.; Silvestri, A.; Solarz, M.; Spiczak, G.M.; Spiering, C.; Steele, D.; Steffen, P.; Stokstad, R.G.; Sudoff, P.; Sudoff, K.-H.; Sulanke, K.-H.; Taboada, I.; Thollander, L.; Tilav, S.; Wagner, W.; Walck, C.; Weinheimer, C.; Wiebusch, C.H.; Wiedemann, C.; Wischnewski, R.; Wissing, H.; Woschnagg, K.; Yodh, G.; Young, S

    2003-06-30

    We present results from the AMANDA high energy neutrino telescope located at the South Pole. They include measurements of the atmospheric neutrino flux, search for UHE point sources, and diffuse sources producing electromagnetic/hadronic showers at the detector or close to it.

  12. The Atacama Submillimeter Telescope Experiment

    Science.gov (United States)

    Sekimoto, Yutaro; Kawabe, Ryohei; Yamamoto, Satoshi; Hasegawa, Tetsuo

    1999-10-01

    We have a plan to operate a new 10 m telescope at Pampa la Bola (4800 m) in Chile as one of Japanese R&D activities for Atacama Large Millimeter/Submillimeter Array. Technical and scientific purposes in this experiment are to develop and evaluate a high precision 10 m antenna under exposed conditions at the site, to develop and test low-noise submillimeter receivers and new SIS photon detectors, to test various techniques for submillimeter observations, and to explore the southern hemisphere in the submillimeter band: Galactic Center, Magellanic Clouds, and so on. The SIS mixer receivers at the Cassegrain focus covers 100, 230, 350, 500, 670, and 810 GHz bands for spectral line observations. A digital autocorrelator consisted of four modules with 500 MHz bandwidth is mounted in a container near the telescope. Two power generators with a capability of 200 kW are installed at the site. The telescope will be operated remotely from Japan via a commercial satellite communication system. After a test operation at Nobeyama for one and a half years, the telescope will be transported to Pampa la Bola in August 2001.

  13. Cern Axion Solar Telescope (CAST)

    CERN Multimedia

    2002-01-01

    The CERN Solar Axion Telescope, CAST, aims to shed light on a 30-year-old riddle of particle physics by detecting axions originating from the 15 million degree plasma in the Sun 's core. Axions were proposed as an extension to the Standard Model of particle physics to explain why CP violation is observed in weak but not strong interactions.

  14. Monster telescope hunts blue planets

    CERN Multimedia

    Leake, J

    2003-01-01

    BRITAIN is to back a project to build the world's biggest telescope - so powerful that it could see life-bearing planets in other solar systems. It will need the largest mirror ever built at about 100 metres in diameter (1/2 page).

  15. Push-To Telescope Mathematics

    Science.gov (United States)

    Teets, Donald

    2012-01-01

    Two coordinate systems are related here, one defined by the earth's equator and north pole, the other by the orientation of a telescope at some location on the surface of the earth. Applying an interesting though somewhat obscure property of orthogonal matrices and using the cross-product simplifies this relationship, revealing that a surprisingly…

  16. Results from the AMANDA telescope

    CERN Document Server

    Bouhali, O

    2003-01-01

    We present results from the AMANDA high energy neutrino telescope located at the South Pole. They include measurements of the atmospheric neutrino flux, search for UHE point sources, and diffuse sources producing electromagnetic/hadronic showers at the detector or close to it. (4 refs).

  17. Ultrasonic Phased Array Assessment of the Interference Fit and Leak Path of the North Anna Unit 2 Control Rod Drive Mechanism Nozzle 63 with Destructive Validation

    Energy Technology Data Exchange (ETDEWEB)

    Crawford, Susan L.; Cinson, Anthony D.; MacFarlan, Paul J.; Hanson, Brady D.; Mathews, Royce

    2012-08-01

    The objective of this investigation was to evaluate the efficacy of ultrasonic testing (UT) for primary water leak path assessments of reactor pressure vessel (RPV) upper head penetrations. Operating reactors have experienced leakage when stress corrosion cracking of nickel-based alloy penetrations allowed primary water into the annulus of the interference fit between the penetration and the low-alloy steel RPV head. In this investigation, UT leak path data were acquired for an Alloy 600 control rod drive mechanism nozzle penetration, referred to as Nozzle 63, which was removed from the North Anna Unit 2 reactor when the RPV head was replaced in 2002. In-service inspection prior to the head replacement indicated that Nozzle 63 had a probable leakage path through the interference fit region. Nozzle 63 was examined using a phased-array UT probe with a 5.0-MHz, eight-element annular array. Immersion data were acquired from the nozzle inner diameter surface. The UT data were interpreted by comparing to responses measured on a mockup penetration with known features. Following acquisition of the UT data, Nozzle 63 was destructively examined to determine if the features identified in the UT examination, including leakage paths and crystalline boric acid deposits, could be visually confirmed. Additional measurements of boric acid deposit thickness and low-alloy steel wastage were made to assess how these factors affect the UT response. The implications of these findings for interpreting UT leak path data are described.

  18. Overdenture dengan Pegangan Telescopic Crown

    Directory of Open Access Journals (Sweden)

    Pambudi Santoso

    2014-06-01

    Full Text Available Kaitan presisi merupakan alat retensi mekanis yang menghubungkan antara satu atau lebih pegangan gigi tiruan, yang bertujuan untuk menambah retensi dan/atau stabilisasi. Kaitan presisi dapat digunakan secara luas pada gigi tiruan cekat, gigi tiruan sebagian lepasan, overdenture, implant untuk retensi overdenture, dan protesa maksilo fasial. Overdenture dengan kaitan presisi dapat membantu dalam pembagian beban kunyah, meminimalkan trauma pada gigi pegangan dan jaringan lunak, meminimalkan resorbsi tulang, dan meningkatkan estetik dan pengucapan suara. Salah satu jenis dari kaitan presisi adalah telescopic crown, terdiri dari 2 macam mahkota, yaitu mahkota primer yang melekat secara permanen pada gigi penyangga, dan mahkota sekunder yang melekat pada gigi tiruan. Tujuan pemaparan kasus ini adalah untuk memberikan informasi tentang rehabilitasi pasien edentulous sebagian rahang atas dengan telescopic crown..  Pasien wanita berusia 45 tahun datang ke klinik prostodonsia RSGM Prof.Soedomo dengan keluhan ingin dibuatkan gigi tiruan. Pasien kehilangan gigi 11 12 15 16 17 21 22 24 25 26 dan 27 yang diindikasikan untuk pembuatan overdenture gigi tiruan sebagian lepasan (GTS kerangka logam dengan pegangan telescopic crown pada gigi 13 dan 14 dengan sistem parallel-sided crown. Tahap-tahap pembuatan telescopic crown yaitu mencetak model study dengan catatan gigit pendahuluan. Perawatan saluran dilakukan pada akar gigi 13, dilanjutkan pemasangan pasak fiber serta rewalling dinding bukal. Gigi 13 dan 14 dilakukan preparasi mahkota penuh, dilanjutkan dengan pencetakan model kerja untuk coping primer dan kerangka logam dengan metode double impression. Coping primer disementasi pada gigi penyangga, dilanjutkan pasang coba coping sekunder beserta kerangka logam. Selanjutnya dilakukan pencatatan gigit, pencetakan model kerja, penyusunan gigi dan pasang coba penyusunan gigi pada pasien. Prosedur dilanjutkan dengan proses di laboratorium, serta insersi pada

  19. Grossesse tubaire rompue associée à une grossesse utérine évolutive

    OpenAIRE

    Kazadi-Buanga, J. (J.); Laparte, M.C. (María Carmen); G López-García

    1992-01-01

    Reconnaître une grossesse ectopique, disait Werth cité par Mondor [14], est facile dans bien des cas, mais dans d'autres cas qui ne sont pas nombreux c'est l'une des épreuves les plus difficiles de diagnostic gynécologique et beaucoup de gynécologues exercés ont dû s'y arrêter plus d'une fois. Werth pensait certainement aux formes atypiques et peut-être aussi à la forme associant grossesses intra-utérine et extra-utérine puisque la première description autopsique de Duvernet date de 1708 [2, ...

  20. Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis.

    Science.gov (United States)

    Kim, Yu-Mi; Kim, Wan-Young; Lee, Hyun-Wook; Kim, Jin; Kwon, H Moo; Klein, Janet D; Sands, Jeff M; Kim, Dongun

    2009-01-01

    In our previous studies of varying osmotic diuresis, UT-A1 urea transporter increased when urine and inner medullary (IM) interstitial urea concentration decreased. The purposes of this study were to examine 1) whether IM interstitial tonicity changes with different urine urea concentrations during osmotic dieresis and 2) whether the same result occurs even if the total urinary solute is decreased. Rats were fed a 4% high-salt diet (HSD) or a 5% high-urea diet (HUD) for 2 wk and compared with the control rats fed a regular diet containing 1% NaCl. The urine urea concentration decreased in HSD but increased in HUD. In the IM, UT-A1 and UT-A3 urea transporters, CLC-K1 chloride channel, and tonicity-enhanced binding protein (TonEBP) transcription factor were all increased in HSD and decreased in HUD. Next, rats were fed an 8% low-protein diet (LPD) or a 0.4% low-salt diet (LSD) to decrease the total urinary solute. Urine urea concentration significantly decreased in LPD but significantly increased in LSD. Rats fed the LPD had increased UT-A1 and UT-A3 in the IM base but decreased in the IM tip, resulting in impaired urine concentrating ability. The LSD rats had decreased UT-A1 and UT-A3 in both portions of the IM. CLC-K1 and TonEBP were unchanged by LPD or LSD. We conclude that changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis.

  1. High-Dispersion Spectroscopic Observations of Comet C/2012 S1 (ISON) with the Subaru Telescope

    Science.gov (United States)

    Shinnaka, Yoshiharu; Kawakita, Hideyo; Nagashima, Masayoshi; Hitomi, Kobayashi; Decock, Alice; Jehin, Emmanuel; Boice, Daniel C.

    2014-11-01

    Comet C/2012 S1 (ISON) was one of the Oort cloud comets and dynamically new. This comet was broken at its perihelion passage on UT 2013 November 28.1 (at Rh ~ 17 solar radius). We observed the comet C/2012 S1 (ISON) on UT 2013 November 15 with the High Dispersion Spectrograph (HDS) mounted on the Subaru Telescope atop Mauna Kea, Hawaii. Its heliocentric and geocentric distances were 0.601 and 0.898 AU, respectively. We selected the slit size of 0”.5 x 9”.0 on the sky to achieve the spectral resolution of R = 72,000 from 550 to 830 nm. The total exposure time of comet C/2012 S1 (ISON) was 1200 seconds. We detected many emission lines caused from radicals (e.g., CN, C2, NH2), ions (H2O+), atoms ([OI] and Na I) and also many unidentified lines in the spectra. We report the (1) the ortho-to-para abundance ratios (OPRs) of water and ammonia estimated from the high-dispersion spectra of H2O+ and NH2, (2) the green-to-red line ratio of forbidden oxygen emissions, (3) the isotopic ratios of C2 (the carbon isotopic ratio from Swan band) and CN (the carbon and nitrogen isotopic ratios from red band), (4) the sodium-to-continuum ratio of comet C/2012 S1 (ISON).

  2. A UT/LS ozone climatology of the nineteen seventies deduced from the GASP aircraft measurement program

    Directory of Open Access Journals (Sweden)

    C. Schnadt Poberaj

    2007-11-01

    Full Text Available We present ozone measurements of the Global Atmospheric Sampling Program (GASP performed from four commercial and one research aircraft in the late 1970s. The GASP quality assurance and control program was reviewed, and an ozone climatology of the upper troposphere and lower stratosphere (UT/LS of the years 1975–1979 was built. The data set was estimated to have an overall uncertainty of 9% or 3 ppb whichever is greater for the first two years and 4% or 3 ppb for the remaining years, i.e. after implementation of silicone rubber membranes in the pumps. Two cases of nearly coincident flights of two GASP airliners along the same flight route, and the comparison with independent observations from the literature, including ozonesondes and aircraft campaigns, indicate that the ozone measurements are of high quality. The UT/LS climatology of the GASP data set is in general agreement with that derived from MOZAIC in the 1990s in regions covered by both programmes. GASP provides unique large-scale climatological information on UT/LS ozone above the northern hemisphere Pacific region, which is not covered by MOZAIC. There, the GASP climatology confirms several characteristic features derived from individual research aircraft campaigns and from ozone soundings. In particular, summertime ozone in the UT over the midlatitude eastern Pacific Ocean was significantly lower in the 1970s than over the American continent. The generally lower ozone concentrations in the tropics near the dateline as compared to farther east are indicative of convective uplifting of ozone poor air from the marine boundary layer.

  3. A UT/LS ozone climatology of the nineteen seventies deduced from the GASP aircraft measurement program

    Science.gov (United States)

    Schnadt Poberaj, C.; Staehelin, J.; Brunner, D.; Thouret, V.; Mohnen, V.

    2007-11-01

    We present ozone measurements of the Global Atmospheric Sampling Program (GASP) performed from four commercial and one research aircraft in the late 1970s. The GASP quality assurance and control program was reviewed, and an ozone climatology of the upper troposphere and lower stratosphere (UT/LS) of the years 1975-1979 was built. The data set was estimated to have an overall uncertainty of 9% or 3 ppb whichever is greater for the first two years and 4% or 3 ppb for the remaining years, i.e. after implementation of silicone rubber membranes in the pumps. Two cases of nearly coincident flights of two GASP airliners along the same flight route, and the comparison with independent observations from the literature, including ozonesondes and aircraft campaigns, indicate that the ozone measurements are of high quality. The UT/LS climatology of the GASP data set is in general agreement with that derived from MOZAIC in the 1990s in regions covered by both programmes. GASP provides unique large-scale climatological information on UT/LS ozone above the northern hemisphere Pacific region, which is not covered by MOZAIC. There, the GASP climatology confirms several characteristic features derived from individual research aircraft campaigns and from ozone soundings. In particular, summertime ozone in the UT over the midlatitude eastern Pacific Ocean was significantly lower in the 1970s than over the American continent. The generally lower ozone concentrations in the tropics near the dateline as compared to farther east are indicative of convective uplifting of ozone poor air from the marine boundary layer.

  4. Seasonal cycles and variability of O3 and H2O in the UT/LMS during SPURT

    Directory of Open Access Journals (Sweden)

    M. Krebsbach

    2006-01-01

    Full Text Available Airborne high resolution in situ measurements of a large set of trace gases including ozone (O3 and total water (H2O in the upper troposphere and the lowermost stratosphere (UT/LMS have been performed above Europe within the SPURT project. SPURT provides an extensive data coverage of the UT/LMS in each season within the time period between November 2001 and July 2003. In the LMS a distinct spring maximum and autumn minimum is observed in O3, whereas its annual cycle in the UT is shifted by 2–3 months later towards the end of the year. The more variable H2O measurements reveal a maximum during summer and a minimum during autumn/winter with no phase shift between the two atmospheric compartments. For a comprehensive insight into trace gas composition and variability in the UT/LMS several statistical methods are applied using chemical, thermal and dynamical vertical coordinates. In particular, 2-dimensional probability distribution functions serve as a tool to transform localised aircraft data to a more comprehensive view of the probed atmospheric region. It appears that both trace gases, O3 and H2O, reveal the most compact arrangement and are best correlated in the view of potential vorticity (PV and distance to the local tropopause, indicating an advanced mixing state on these surfaces. Thus, strong gradients of PV seem to act as a transport barrier both in the vertical and the horizontal direction. The alignment of trace gas isopleths reflects the existence of a year-round extra-tropical tropopause transition layer. The SPURT measurements reveal that this layer is mainly affected by stratospheric air during winter/spring and by tropospheric air during autumn/summer. Normalised mixing entropy values for O3 and H2O in the LMS appear to be maximal during spring and summer, respectively, indicating highest variability of these trace gases during the respective seasons.

  5. Predicting relatedness of bacterial genomes using the chaperonin-60 universal target (cpn60 UT): application to Thermoanaerobacter species.

    Science.gov (United States)

    Verbeke, Tobin J; Sparling, Richard; Hill, Janet E; Links, Matthew G; Levin, David; Dumonceaux, Tim J

    2011-05-01

    D.R. Zeigler determined that the sequence identity of bacterial genomes can be predicted accurately using the sequence identities of a corresponding set of genes that meet certain criteria [32]. This three-gene model for comparing bacterial genome pairs requires the determination of the sequence identities for recN, thdF, and rpoA. This involves the generation of approximately 4.2kb of genomic DNA sequence from each organism to be compared, and also normally requires that oligonucleotide primers be designed for amplification and sequencing based on the sequences of closely related organisms. However, we have developed an analogous mathematical model for predicting the sequence identity of whole genomes based on the sequence identity of the 542-567 base pair chaperonin-60 universal target (cpn60 UT). The cpn60 UT is accessible in nearly all bacterial genomes with a single set of universal primers, and its length is such that it can be completely sequenced in one pair of overlapping sequencing reads via di-deoxy sequencing. These mathematical models were applied to a set of Thermoanaerobacter isolates from a wood chip compost pile and it was shown that both the one-gene cpn60 UT-based model and the three-gene model based on recN, rpoA, and thdF predicted that these isolates could be classified as Thermoanaerobacter thermohydrosulfuricus. Furthermore, it was found that the genomic prediction model using cpn60 UT gave similar results to whole-genome sequence alignments over a broad range of taxa, suggesting that this method may have general utility for screening isolates and predicting their taxonomic affiliations.

  6. UII and UT in grouper: cloning and effects on the transcription of hormones related to growth control.

    Science.gov (United States)

    Sun, Caiyun; Duan, Da; Li, Bo; Qin, Chaobin; Jia, Jirong; Wang, Bin; Dong, Haiyan; Li, Wensheng

    2014-01-01

    Urotensin II (UII) is a cyclic peptide that was originally extracted from the caudal neurosecretory system (CNSS) of fish. UII is well known to exhibit cardiovascular, ventilatory, and motor effects in vertebrates. Studies have reported that UII exerts mitogenic effects and can act as an autocrine/paracrine growth factor in mammals. However, similar information in fish is limited. In this study, the full-length cDNAs of UII and its receptor (UT) were cloned and characterized in the orange-spotted grouper. UII and UT were expressed ubiquitously in various tissues in grouper, and particularly high levels were observed in the CNSS, CNS, and ovary. A functional study showed that UT was coupled with intracellular Ca2+ mobilization in HEK293 cells. Studies carried out using i.p. injections of UII in grouper showed the following: i) in the hypothalamus, UII can significantly stimulate the mRNA expression of ghrh and simultaneously inhibit the mRNA expression of somatostatin 1 (ss1) and ss2 3 h after injection; ii) in the pituitary, UII also significantly induced the mRNA expression of gh 6 and 12  h after injection; and iii) in the liver, the mRNA expression levels of ghr1/ghr2 and igf1/igf2 were markedly increased 12 and 3  h after the i.p. injection of UII respectively. These results collectively indicate that the UII/UT system may play a role in the promotion of the growth of the orange-spotted grouper.

  7. Protonation of Alcohols in Sulfuric Acid Solutions at UT/LS Conditions

    Science.gov (United States)

    Michelsen, R. R.; Vernier, K.; Axson, J.; Morley, D.

    2007-12-01

    The protonation of several small alcohols (ethanol, 2-propanol, and 1-butanol) in cold sulfuric acid aqueous solutions was measured using variable temperature 13C nuclear magnetic resonance (NMR) spectroscopy. The acidity of the sulfuric acid + deuterium oxide solutions ranged from 43 to 81 weight percent (wt %) H2SO4. The pKBH+ values, which are a measure of the acidity of each alcohol, range from -2.0 for butanol at room temperature to -2.2 for ethanol at -20°C. The protonation enthalpies of the three alcohols over the temperature range of 22°C to -35°C were found to be small and negative, ranging from -1.8 kJ mol-1 for 2-propanol to -2.3 kJ mol-1 for ethanol. A small, negative protonation enthalpy means that the degree of protonation of the alcohol slightly decreases as temperature decreases. The pKBH+values and protonation enthalpies are used to predict the form of dissolved alcohols in sulfate aerosols. For typical upper troposphere/lower stratosphere (UT/LS) conditions (40-70 wt % H2SO4 and 220 K), all three alcohols increase from approximately 10% protonated in 40 wt % H2SO4 to over 60% protonated in 70 wt % H2SO4. The percent of protonated alcohol depends more strongly on m*, the slope factor of the excess acidity treatment, than on pKBH+ values. This relationship may reflect solvation effects. The treatment of strongly acidic, non-ideal solutions as applied to organic solutes in sulfate aerosol particles will be discussed.

  8. Improved Stratigraphic Interpretation of Dense Lacustrine Carbonates from Lake Bonneville, UT

    Science.gov (United States)

    Steponaitis, E.; McGee, D.; Quade, J.

    2014-12-01

    Recent work on the past hydroclimate of the Bonneville Basin has utilized dense, laminated carbonate deposits that formed beneath the surface of Lake Bonneville starting around 26 ka (McGee et al. 2012). These calcite and aragonite deposits form in calm, protected spaces that have been submerged by the lake, including hillside caves, cracks in bedrock, and interstitial spaces in tufa and abandoned beach gravel deposits. Dense lacustrine carbonates are very useful for paleoclimate studies because they can be used to develop continuous records of lake chemistry anchored by precise U-Th dates. However, many questions remain about the conditions in which these dense carbonates form: at what depth range do these carbonates form, and can basal and top ages help constrain the lake level curve? Do coeval carbonates formed at different depths in the lake preserve information about vertical gradients in lake water properties like δ18O and 87Sr/86Sr? To address these questions and others, this study examines a sequence of dense lacustrine carbonates deposited within bedrock, tufa, and abandoned shoreline gravels from Stansbury Island, UT. We use U-Th dating, local stratigraphic interpretations, and previously established lake level constraints to draw insights into the formation and context of these deposits. Improved understanding of dense lacustrine carbonates will facilitate more detailed and accurate interpretations of their stratigraphic significance, and ultimately, aid the development of improved paleoclimate records from Lake Bonneville and beyond. McGee, D., et al. 2012. Lacustrine Cave Carbonates : Novel Archives of Paleohydrologic Change in the Bonneville Basin (Utah , USA). Earth and Planetary Science Letters (351-352): 182-194.

  9. The effect of rootstocks on the growth and yielding of sour cherry cv. 'Łutówka'

    Directory of Open Access Journals (Sweden)

    Stanisław Wociór

    2012-12-01

    Full Text Available The strength of growth of 'Łutówka' trees was related to the soil quality and the rootstock. Measurements of the tree trunks and the crown size showed that on fertile soil the trees grafted on Mahaleb cherry grew worse, forming by 12% thinner trunks and by over 20% (significantly smaller crowns as compared to Mazzard cherry trees. On poor sandy-loamy soil the crowns of trees grafted on Mahaleb were significantly, more than 40% bigger than those on Mazzard cherry. No significant differences in the yielding and productivity of trees grafted on Mahaleb and Mazzard cherry trees were found on grey brown podzolic soil. The experiment conducted on sandy-loamy soil pointed to significant differences in the yielding and productivity between 'Łutówka' trees grafted on the studied rootstocks. The trees grafted on Mahaleb cherry in both studied years were characterized by significantly greater productivity than on the other rootstocks. Significantly higher yields were gathered from the trees on Mahaleb cherry than on vegetative rootstocks, and by 70% higher than on Mazzard cherry. P-HL A rootstock is of little use in the planting of 'Łutówka', which grown poorly on light soils. Besides poor growth and yielding, in longer dry periods the studies found the appearance of chlorosis of magnesium on older leaves, and even wilting of the leaves.

  10. Association analysis of urotensin II gene (UTS2 and flanking regions with biochemical parameters related to insulin resistance.

    Directory of Open Access Journals (Sweden)

    María E Sáez

    Full Text Available BACKGROUND: Urotensin II (UII is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR known as GPR14 or urotensin receptor (UTR. UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release. OBJECTIVE: Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA. RESULTS AND CONCLUSIONS: We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.

  11. [Treatment of corneal endothelial disorders by DMEK and UT-DSAEK. Indications, complications, results and follow-up].

    Science.gov (United States)

    Bachmann, B; Schaub, F; Cursiefen, C

    2016-03-01

    Various techniques for posterior lamellar keratoplasty have been established for the clinical routine and continuously improved during the last 15 years so that an extremely rapid recovery of vision is possible due to very thin transplants. Descemet membrane endothelial keratoplasty (DMEK) is the method of choice for simple corneal endothelial diseases and has already been applied in complex conditions of the anterior segment. The learning curve for DMEK is comparatively long and the risk of complications in complex anterior segment pathologies is higher than in Descemet's stripping automated endothelial keratoplasty (DSAEK); however, DMEK results in better visual outcome and less graft rejections than DSAEK. The latest evolution in posterior lamellar transplant surgery is ultrathin DSAEK (UT-DSAEK), where the grafted lamella is much thinner than in conventional DSAEK. Currently available data suggest that the resulting visual acuity after UT-DSAEK is close to the visual acuity seen after DMEK; however, studies comparing the results after DMEK and UT-DSAEK are so far lacking. Whether the transplantation of these very thin DSAEK grafts also results in endothelial cell densities and graft rejection rates comparable to DMEK has to be proven.

  12. New Control Software of the 188cm Telescope of Okayama Astrophysical Observatory

    Science.gov (United States)

    Yoshida, Michitoshi; Shimizu, Yasuhiro; Watanabe, Etsuji; Yanagisawa, Kenshi; Uraguchi, Fumihiro

    2002-12-01

    We developed the telescope control software for the 188cm telescope of Okayama Astrophysical Observatory (OAO) based on Java technology. Basically, the software consists of two processes running on separate Java virtual machines; one of which is the "Command Dispatcher (CD)" and the other is the "User Interface (UI)". Among the two, CD is the main engine/server of the telescope control, whereas UI is just a client. The "standard" UI we provide is a graphical user interface written in Java/Swing. CD communicates with the local control units (LCUs) of the telescope through RS232C. CD is a Java multi-thread program, in which a number of threads run simultaneously. The threads running in CD are the follows: UNIX socket servers for external communications, socket opener for on-demand open/close of a socket port, socket client manager, auto-guider and dome watcher, internal command dispatcher, status manager, status collector, RS232C writer and reader, logger, and control units. The above "control units" are software models ("objects") of the telescope system. We introduced four control units- "Telescope", "Dome", "Weather-Monitor", and "Pointing"- for telescope control. The first three units are simple software models of the real-worlds devices. The last one, "Pointing", is a unit which abstracts pointing procedure of the telescope. CD and UI communicate with each other using UNIX socket. The command protocol of this communication is fairly simple, and observation instruments, auto guider, or additional UI for remote observation are also able to communicate with CD through socket using this protocol. CD opens and closes socket ports for communication on demand according to the request of client process (UI, instruments etc.), so that any clients can be connected to CD dynamically.

  13. The automated Palomar 60 inch telescope

    OpenAIRE

    Cenko, S Bradley; Fox, Derek B.; Moon, Dae-Sik; Harrison, Fiona A.; Kulkarni, S.R.; Henning, John R.; Guzman, C. Dani; Bonati, Marco; Smith, Roger M.; Thicksten, Robert P.; Doyle, Michael W.; Petrie, Hal L.; Gal-Yam, Avishay; Soderberg, Alicia M.; Anagnostou, Nathaniel L.

    2006-01-01

    We have converted the Palomar 60-inch telescope (P60) from a classical night assistant-operated telescope to a fully robotic facility. The automated system, which has been operational since September 2004, is designed for moderately fast (t

  14. Alignment of the James Webb Space Telescope optical telescope element

    Science.gov (United States)

    Glassman, Tiffany; Levi, Joshua; Liepmann, Till; Hahn, Walter; Bisson, Gary; Porpora, Dan; Hadjimichael, Theo

    2016-07-01

    The optical telescope element (OTE) of the James Webb Space Telescope has now been integrated and aligned. The OTE comprises the flight mirrors and the structure that supports them - 18 primary mirror segments, the secondary mirror, and the tertiary and fine steering mirrors (both housed in the aft optics subsystem). The primary mirror segments and the secondary mirror have actuators to actively control their positions during operations. This allows the requirements for aligning the OTE subsystems to be in the range of microns rather than nanometers. During OTE integration, the alignment of the major subsystems of the OTE structure and optics were controlled to ensure that, when the telescope is on orbit and at cryogenic temperatures, the active mirrors will be within the adjustment range of the actuators. Though the alignment of this flagship mission was complex and intricate, the key to a successful integration process turned out to be very basic: a clear, concise series of steps employing advanced planning, backup measurements, and cross checks that this multi-organizational team executed with a careful and methodical approach. This approach was not only critical to our own success but has implications for future space observatories.

  15. Origins Space Telescope: Telescope Design and Instrument Specifications

    Science.gov (United States)

    Meixner, Margaret; Carter, Ruth; Leisawitz, David; Dipirro, Mike; Flores, Anel; Staguhn, Johannes; Kellog, James; Roellig, Thomas L.; Melnick, Gary J.; Bradford, Charles; Wright, Edward L.; Zmuidzinas, Jonas; Origins Space Telescope Study Team

    2017-01-01

    The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, one of the four science and technology definition studies of NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey. The renaming of the mission reflects Origins science goals that will discover and characterize the most distant galaxies, nearby galaxies and the Milky Way, exoplanets, and the outer reaches of our Solar system. This poster will show the preliminary telescope design that will be a large aperture (>8 m in diameter), cryogenically cooled telescope. We will also present the specifications for the spectrographs and imagers over a potential wavelength range of ~10 microns to 1 millimeter. We look forward to community input into this mission definition over the coming year as we work on the concept design for the mission. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. We welcome you to contact the Science and Technology Definition Team (STDT) with your science needs and ideas by emailing us at firsurveyor_info@lists.ipac.caltech.edu.

  16. The Medium Size Telescopes of the Cherenkov Telescope Array

    CERN Document Server

    Pühlhofer, G

    2016-01-01

    The Cherenkov Telescope Array (CTA) is the planned next-generation instrument for ground-based gamma-ray astronomy, covering a photon energy range of ~20 GeV to above 100 TeV. CTA will consist of the order of 100 telescopes of three sizes, installed at two sites in the Northern and Southern Hemisphere. This contribution deals with the 12 meter Medium Size Telescopes (MST) having a single mirror (modified Davies-Cotton, DC) design. In the baseline design of the CTA arrays, 25 MSTs in the South and 15 MSTs in the North provide the necessary sensitivity for CTA in the core energy range of 100 GeV to 10 TeV. DC-MSTs will be equipped with photomultiplier (PMT)-based cameras. Two options are available for these focal plane instruments, that will be provided by the FlashCam and the NectarCAM sub-consortia. In this contribution, a short introduction to the projects and their status is given.

  17. The Principles of Astronomical Telescope Design

    CERN Document Server

    Cheng, Jingquan

    2009-01-01

    Presents a summary of the author's twenty five years of experience in telescope design. This work provides a general introduction to various aspects of telescope design. It discusses the theory behind telescope design. It covers Radio, Infrared, Optical, X-Ray and Gamma-Ray wavelengths

  18. The Hubble Space Telescope: Problems and Solutions.

    Science.gov (United States)

    Villard, Ray

    1990-01-01

    Presented is the best understanding of the flaw discovered in the optics of the Hubble Space Telescope and the possible solutions to the problems. The spherical aberration in the telescope's mirror and its effect on the quality of the telescope's imaging ability is discussed. (CW)

  19. CFRP lightweight structures for extremely large telescopes

    DEFF Research Database (Denmark)

    Jessen, Niels Christian; Nørgaard-Nielsen, Hans Ulrik; Schroll, J.

    2008-01-01

    Telescope structures are traditionally built out of steel. To improve the possibility of realizing the ambitious extremely large telescopes, materials with a higher specific stiffness and a lower coefficient of thermal expansion are needed. An important possibility is Carbon Fibre Reinforced...... Plastic (CFRP). The advantages of using CFRP for the secondary mirror support structure of the European overwhelmingly large telescope are discussed....

  20. Focusing X-Ray Telescopes

    Science.gov (United States)

    O'Dell, Stephen; Brissenden, Roger; Davis, William; Elsner, Ronald; Elvis, Martin; Freeman, Mark; Gaetz, Terrance; Gorenstein, Paul; Gubarev, Mikhall; Jerlus, Diab; Juda, Michael; Kolodziejczak, Jeffrey; Murray, Stephen; Petre, Robert; Podgorski, William; Ramsey, Brian; Reid, Paul; Saha, Timo; Wolk, Scott; Troller-McKinstry, Susan; Weisskopf, Martin; Wilke, Rudeger; Zhang, William

    2010-01-01

    During the half-century history of x-ray astronomy, focusing x-ray telescopes, through increased effective area and finer angular resolution, have improved sensitivity by 8 orders of magnitude. Here, we review previous and current x-ray-telescope missions. Next, we describe the planned next-generation x-ray-astronomy facility, the International X-ray Observatory (IXO). We conclude with an overview of a concept for the next next-generation facility, Generation X. Its scientific objectives will require very large areas (about 10,000 sq m) of highly-nested, lightweight grazing-incidence mirrors, with exceptional (about 0.1-arcsec) resolution. Achieving this angular resolution with lightweight mirrors will likely require on-orbit adjustment of alignment and figure.

  1. The Ortega Telescope Andor CCD

    Science.gov (United States)

    Tucker, M.; Batcheldor, D.

    2012-07-01

    We present a preliminary instrument report for an Andor iKon-L 936 charge-couple device (CCD) being operated at Florida Tech's 0.8 m Ortega Telescope. This camera will replace the current Finger Lakes Instrumentation (FLI) Proline CCD. Details of the custom mount produced for this camera are presented, as is a quantitative and qualitative comparison of the new and old cameras. We find that the Andor camera has 50 times less noise than the FLI, has no significant dark current over 30 seconds, and has a smooth, regular flat field. The Andor camera will provide significantly better sensitivity for direct imaging programs and, once it can be satisfactorily tested on-sky, will become the standard imaging device on the Ortega Telescope.

  2. Telescoping phenomenon in pathological gambling

    DEFF Research Database (Denmark)

    Grant, Jon E; Odlaug, Brian Lawrence; Mooney, Marc E

    2012-01-01

    The course of pathological gambling (PG) in women has been described as having a later age of initiation but a shorter time to problematic gambling ("telescoped"). This study examined evidence for telescoping and its relationship with comorbidities. Seventy-one treatment-seeking individuals with PG...... underwent a diagnostic interview to examine gambling behaviors, age at initiation of gambling, and time from initiation to meeting criteria for PG. The women had a higher mean age at gambling initiation compared with that of the men (mean [SD] age, 31.3 [13.0] years, compared with 22.4 [7.9] years; p = 0...... and suggests a need for greater clinical focus on the gender differences of gambling behavior....

  3. Cherenkov Telescope Array Data Management

    CERN Document Server

    Lamanna, G; Contreras, J L; Knödlseder, J; Kosack, K; Neyroud, N; Aboudan, A; Arrabito, L; Barbier, C; Bastieri, D; Boisson, C; Brau-Nogué, S; Bregeon, J; Bulgarelli, A; Carosi, A; Costa, A; De Cesare, G; Reyes, R de los; Fioretti, V; Gallozzi, S; Jacquemier, J; Khelifi, B; Kocot, J; Lombardi, S; Lucarelli, F; Lyard, E; Maier, G; Massimino, P; Osborne, J P; Perri, M; Rico, J; Sanchez, D A; Satalecka, K; Siejkowski, H; Stolarczyk, T; Szepieniec, T; Testa, V; Walter, R; Ward, J E; Zoli, A

    2015-01-01

    Very High Energy gamma-ray astronomy with the Cherenkov Telescope Array (CTA) is evolving towards the model of a public observatory. Handling, processing and archiving the large amount of data generated by the CTA instruments and delivering scientific products are some of the challenges in designing the CTA Data Management. The participation of scientists from within CTA Consortium and from the greater worldwide scientific community necessitates a sophisticated scientific analysis system capable of providing unified and efficient user access to data, software and computing resources. Data Management is designed to respond to three main issues: (i) the treatment and flow of data from remote telescopes; (ii) "big-data" archiving and processing; (iii) and open data access. In this communication the overall technical design of the CTA Data Management, current major developments and prototypes are presented.

  4. Highlights from the Telescope Array

    Directory of Open Access Journals (Sweden)

    Matthews J.N.

    2016-01-01

    Full Text Available The Telescope Array measures the properties of ultra high energy cosmic ray induced extensive air showers. We do this using a variety of techniques including an array of scintillator detectors to sample the footprint of the air shower when it reaches the Earth’s surface and telescopes to measure the fluorescence and Cerenkov light of the air shower. From this we determine the energy spectrum and chemical composition of the primary particles. We also search for sources of cosmic rays and anisotropy. We have found evidence of a possible source of ultra high energy cosmic rays in the northern sky. The experiment and its most recent measurements will be discussed.

  5. The LWA1 Radio Telescope

    CERN Document Server

    Ellingson, S W; Craig, J; Hartman, J; Dowell, J; Wolfe, C N; Clarke, T E; Hicks, B C; Kassim, N E; Ray, P S; Rickard, L J; Schinzel, F K; Weiler, K W

    2012-01-01

    LWA1 is a new radio telescope operating in the frequency range 10-88 MHz, located in central New Mexico. The telescope consists of 258 pairs of dipole-type antennas whose outputs are individually digitized and formed into beams. Simultaneously, signals from all dipoles can be recorded using one of the instrument's "all dipoles" modes, facilitating all-sky imaging. Notable features of the instrument include high intrinsic sensitivity (about 6 kJy zenith system equivalent flux density), large instantaneous bandwidth (up to 78 MHz), and 4 independently-steerable beams utilizing digital "true time delay" beamforming. This paper summarizes the design of LWA1 and its performance as determined in commissioning experiments. We describe the method currently in use for array calibration, and report on measurements of sensitivity and beamwidth.

  6. Focusing Telescopes in Nuclear Astrophysics

    CERN Document Server

    Ballmoos, Peter von

    2007-01-01

    This volume is the first of its kind on focusing gamma-ray telescopes. Forty-eight refereed papers provide a comprehensive overview of the scientific potential and technical challenges of this nascent tool for nuclear astrophysics. The book features articles dealing with pivotal technologies such as grazing incident mirrors, multilayer coatings, Laue- and Fresnel-lenses - and even an optic using the curvature of space-time. The volume also presents an overview of detectors matching the ambitious objectives of gamma ray optics, and facilities for operating such systems on the ground and in space. The extraordinary scientific potential of focusing gamma-ray telescopes for the study of the most powerful sources and the most violent events in the Universe is emphasized in a series of introductory articles. Practicing professionals, and students interested in experimental high-energy astrophysics, will find this book a useful reference

  7. Education and outreach using the falcon telescope network

    Science.gov (United States)

    Gresham, Kimberlee C.; Palma, Christopher; Polsgrove, Daniel E.; Chun, Francis K.; Della-Rose, Devin J.; Tippets, Roger D.

    2016-12-01

    The Falcon Telescope Network (FTN) is a global network of small aperture telescopes developed by the Center for Space Situational Awareness Research in the Department of Physics at the United States Air Force Academy (USAFA). Consisting of commercially available equipment, the FTN is a collaborative effort between USAFA and other educational institutions ranging from two- and four-year colleges to major research universities. USAFA provides the equipment (e.g. telescope, mount, camera, filter wheel, dome, weather station, computers and storage devices) while the educational partners provide the building and infrastructure to support an observatory. The user base includes USAFA along with K-12 and higher education faculty and students. The diversity of the users implies a wide variety of observing interests, and thus the FTN collects images on diverse objects, including satellites, galactic and extragalactic objects, and objects popular for education and public outreach. The raw imagery, all in the public domain, will be accessible to FTN partners and will be archived at USAFA. Currently, there are five Falcon telescopes installed, two in Colorado and one each in Pennsylvania, Chile, and Australia. These five telescopes are in various stages of operational capability but all are remotely operable via a remote desktop application. The FTN team has conducted STEM First Light Projects for three of the U.S. observatories, soliciting proposals from middle and high school students and teachers that suggest and then become what is observed as official STEM first-light objects. Students and teachers learn how to write and submit a proposal as well as how telescopes operate and take data, while university-level students at the U.S. Air Force Academy and The Pennsylvania State University learn how to evaluate proposals and provide feedback to the middle and high school students and teachers. In this paper, we present the current status of the FTN, details of and lessons

  8. The Antares Undersea Neutrino Telescope

    Science.gov (United States)

    Anghinolfi, Marco

    2013-11-01

    Neutrino astronomy is a very promising field of investigation representing a complementary source of information with respect to photon-astronomy. ANTARES, operating off the French Mediterranean coast, is the worlds largest operational underwater neutrino telescope. In these proceedings, in addition to a short detector description, the results of recent analysis will be discussed. The ANTARES project is an important physics experiment but also represents a bench mark for a future large detector of the km3 scale.

  9. Building the Green Bank Telescope

    Science.gov (United States)

    Kellermann, Kenneth I.

    2017-01-01

    In a previous presentation, I reported on how the freak collapse of the NRAO 300-ft transit radio telescope led to the inclusion of $75 million for a new radio telescope in the 1989 Congressional Emergency Supplemental Appropriations Act. But, this was only the beginning. NRAO was faced with challenging specifications and an unworkable schedule, but there was no design and no project team. Only one bid was even close to the Congressional appropriation. In an attempt to meet the unrealistic antenna delivery date, the contractor started construction of the foundation and fabrication of antenna members before the design was finished, leading to retrofits, redesign, and multiple delays. The antenna contractor was twice sold to other companies leading to further delays and cost escalation. In order to recoup their mounting losses, the new owners sued NRAO for $29 million for claimed design changes, and NRAO countersued demanding to be reimbursed for added project management costs and lost scientific data resulting from the seven-year delay in the completion of the telescope. Legal fees and a small net award in favor of the contractor left NRAO and the NSF with a nine million dollar bill which NSF handled by an innovative accounting adjustment.

  10. Academic Training: Deep Space Telescopes

    CERN Multimedia

    Françoise Benz

    2006-01-01

    2005-2006 ACADEMIC TRAINING PROGRAMME LECTURE SERIES 20, 21, 22, 23, 24 February from 11:00 to 12:00 - Council Chamber on 20, 21, 23, 24 February, TH Auditorium, bldg 4 - 3-006, on 22 February Deep Space Telescopes G. BIGNAMI / CNRS, Toulouse, F & Univ. di Pavia, I The short series of seminars will address results and aims of current and future space astrophysics as the cultural framework for the development of deep space telescopes. It will then present such new tools, as they are currently available to, or imagined by, the scientific community, in the context of the science plans of ESA and of all major world space agencies. Ground-based astronomy, in the 400 years since Galileo's telescope, has given us a profound phenomenological comprehension of our Universe, but has traditionally been limited to the narrow band(s) to which our terrestrial atmosphere is transparent. Celestial objects, however, do not care about our limitations, and distribute most of the information about their physics thro...

  11. The NASA Spitzer Space Telescope.

    Science.gov (United States)

    Gehrz, R D; Roellig, T L; Werner, M W; Fazio, G G; Houck, J R; Low, F J; Rieke, G H; Soifer, B T; Levine, D A; Romana, E A

    2007-01-01

    The National Aeronautics and Space Administration's Spitzer Space Telescope (formerly the Space Infrared Telescope Facility) is the fourth and final facility in the Great Observatories Program, joining Hubble Space Telescope (1990), the Compton Gamma-Ray Observatory (1991-2000), and the Chandra X-Ray Observatory (1999). Spitzer, with a sensitivity that is almost three orders of magnitude greater than that of any previous ground-based and space-based infrared observatory, is expected to revolutionize our understanding of the creation of the universe, the formation and evolution of primitive galaxies, the origin of stars and planets, and the chemical evolution of the universe. This review presents a brief overview of the scientific objectives and history of infrared astronomy. We discuss Spitzer's expected role in infrared astronomy for the new millennium. We describe pertinent details of the design, construction, launch, in-orbit checkout, and operations of the observatory and summarize some science highlights from the first two and a half years of Spitzer operations. More information about Spitzer can be found at http://spitzer.caltech.edu/.

  12. QUIJOTE telescope design and fabrication

    Science.gov (United States)

    Gomez, Alberto; Murga, Gaizka; Etxeita, Borja; Sanquirce, Rubén; Rebolo, Rafael; Rubiño-Martin, Jose Alberto; Herreros, José-Miguel; Hoyland, Roger; Gomez, Francisca; Génova-Santos, Ricardo T.; Piccirillo, Lucio; Maffei, Bruno; Watson, Robert

    2010-07-01

    The QUIJOTE CMB experiment aims to characterize the polarization of the CMB in the frequency range 10-30 GHz and large angular scales. It will be installed in the Teide Observatory, following the projects that the Anisotropy of the Cosmic Microwave Background group has developed in the past (Tenerife experiment, IAC-Bartol experiment...) and is running at the present time (VSA, Cosmosomas). The QUIJOTE CMB experiment will consist of two telescopes which will be installed inside a unique enclosure, which is already constructed. The layout of both telescopes is based on an altazimuth mount supporting a primary and a secondary mirror disposed in a offset Gregorian Dragon scheme. The use of industrial-like fabrication techniques, such as sand-mould casting, CNC machining, and laser tracker measuring for alignment, provided the required performances for microwave observation. A fast-track construction scheme, altogether with the use of these fabrication techniques allowed designing and manufacturing the opto-mechanics of the telescope in 14 months prior to delivery for final start-up in December 2008.

  13. Study of defect characteristics essential for NDT testing methods ET, UT and RT

    Energy Technology Data Exchange (ETDEWEB)

    Wirdelius, H. [Det Norske Veritas, Moelndal (Sweden); Oesterberg, Elena [SQC Kvalificeringscentrum AB, Taeby (Sweden)

    2000-10-01

    This paper presents results from a literature review of defect characteristics essential for nondestructive testing (NDT). Most of the major NDT methods are included in the study - ultrasonic testing (UT), radiography (RT) and eddy current testing (ET). The study was performed by means of searching in scientific databases, technical journals, conference proceedings etc. Mainly the following databases were used: CHANS (Chalmers database), INSPEC, NTIS, Ei Compendex, World Surface Coating Abs, METADEX, JICST-Eplus, Aerospace database, Pascal, Eng Materials, SciSearch and Weldasearch. It is concluded that for eddy current testing, the defect geometry, the defect size and the defect orientation influence the outcome signal. A number of investigations address the relationships between the defect parameters like defect depth, length and width and the outcome signal parameters like amplitude, phase and signal shape. Also the phenomena of the electrical contacts between the defect surfaces (for a crack) was studied. Defect parameters that are essential to the quality of ultrasonic testing are defect position in the object (includes the depth), orientation, size, crack surface roughness, closure and tip radius. This investigation has been focused on those parameters that are not that easy to reconstruct and only briefly discussed the influence on the signal response due to defect position, orientation and size. When it comes to radiographic techniques, the most important defect related parameters that influence the quality are the difference in radio opacity of the specimen and defect and the angle between the volumetric extension of the defect and the direction of projection. The defect gape and the morphology of the crack are also very essential parameters. A very simple model of the detectability as a function of depth, width and misorientation (angle to the radiation beam) has been validated and to some extent also verified in a number of papers. Even for defects with

  14. Hard X-ray Modulation Telescope

    Institute of Scientific and Technical Information of China (English)

    LU Fangjun

    2011-01-01

    The Hard X-ray Modulation Telescope (HXMT) will be China's first astronomical satellite. On board HXMT there are three kinds of slat-collimated telescopes, the High Energy X-ray Telescope (HE, 20-250 keV, 5000 cm^2), the Medium Energy X-ray Telescope (ME, 5-30 keV, 952 cm^2), and the Low Energy X-ray Telescope (LE, 1-15 keV, 384 cm^2).

  15. Educational activities with the Faulkes Telescopes

    Science.gov (United States)

    Roberts, S.; Roche, P.; Ross, R.

    2008-06-01

    Las Cumbres Observatory Global Telescope Network (LCOGTN) will eventually provide access to a global network of robotic telescopes for research-based science education. Here we present the educational projects that have been undertaken using the 2-m Faulkes Telescopes in Hawaii and Australia in both the UK and Europe. These include themed observing days in which schools collaborate in their telescope sessions, the development of science portals where schools can upload and share their telescope data, and other innovative projects. Public access to these facilities will increase as IYA2009 approaches.

  16. Hubble Space Telescope: The Telescope, the Observations & the Servicing Mission

    Science.gov (United States)

    1999-11-01

    Today the HST Archives contain more than 260 000 astronomical observations. More than 13 000 astronomical objects have been observed by hundreds of different groups of scientists. Direct proof of the scientific significance of this project is the record-breaking number of papers published : over 2400 to date. Some of HST's most memorable achievements are: * the discovery of myriads of very faint galaxies in the early Universe, * unprecedented, accurate measurements of distances to the farthest galaxies, * significant improvement in the determination of the Hubble constant and thus the age of the Universe, * confirmation of the existence of blacks holes, * a far better understanding of the birth, life and death of stars, * a very detailed look at the secrets of the process by which planets are created. Europe and HST ESA's contribution to HST represents a nominal investment of 15%. ESA provided one of the two imaging instruments - the Faint Object Camera (FOC) - and the solar panels. It also has 15 scientists and computer staff working at the Space Telescope Science Institute in Baltimore (Maryland). In Europe the astronomical community receives observational assistance from the Space Telescope European Coordinating Facility (ST-ECF) located in Garching, Munich. In return for ESA's investment, European astronomers have access to approximately 15% of the observing time. In reality the actual observing time competitively allocated to European astronomers is closer to 20%. Looking back at almost ten years of operation, the head of ST-ECF, European HST Project Scientist Piero Benvenuti states: "Hubble has been of paramount importance to European astronomy, much more than the mere 20% of observing time. It has given the opportunity for European scientists to use a top class instrument that Europe alone would not be able to build and operate. In specific areas of research they have now, mainly due to HST, achieved international leadership." One of the major reasons for

  17. Physicochemical evolution and molecular adaptation of the cetacean osmoregulation-related gene UT-A2 and implications for functional studies.

    Science.gov (United States)

    Wang, Jingzhen; Yu, Xueying; Hu, Bo; Zheng, Jinsong; Xiao, Wuhan; Hao, Yujiang; Liu, Wenhua; Wang, Ding

    2015-03-12

    Cetaceans have an enigmatic evolutionary history of re-invading aquatic habitats. One of their essential adaptabilities that has enabled this process is their homeostatic strategy adjustment. Here, we investigated the physicochemical evolution and molecular adaptation of the cetacean urea transporter UT-A2, which plays an important role in urine concentration and water homeostasis. First, we cloned UT-A2 from the freshwater Yangtze finless porpoise, after which bioinformatics analyses were conducted based on available datasets (including freshwater baiji and marine toothed and baleen whales) using MEGA, PAML, DataMonkey, TreeSAAP and Consurf. Our findings suggest that the UT-A2 protein shows folding similar to that of dvUT and UT-B, whereas some variations occurred in the functional So and Si regions of the selectivity filter. Additionally, several regions of the cetacean UT-A2 protein have experienced molecular adaptations. We suggest that positive-destabilizing selection could contribute to adaptations by influencing its biochemical and conformational character. The conservation of amino acid residues within the selectivity filter of the urea conduction pore is likely to be necessary for urea conduction, whereas the non-conserved amino acid replacements around the entrance and exit of the conduction pore could potentially affect the activity, which could be interesting target sites for future mutagenesis studies.

  18. Detection of neutralizing antibodies to erythropoietin by inhibition of rHuEPO-stimulated EGR1 gene expression in the UT-7/EPO cell line.

    Science.gov (United States)

    Ferguson, Jackie; Bird, Chris; Wadhwa, Meenu; Burns, Chris

    2013-01-31

    Recombinant erythropoietin (rHuEPO) is used extensively to treat anaemia associated with chronic kidney disease. However, the development of neutralizing antibodies (NAbs) to rHuEPO can result in the development of antibody-mediated pure red cell aplasia (PRCA). The detection of NAb in patient sera by in vitro bioassay relies on the inhibition of a cellular response to rHuEPO. Current bioassays for rHuEPO measure proliferation in responsive cell lines such as the erythroleukaemic cell lines, UT-7 and UT-7/EPO, the latter sensitized to EPO. Using these cell lines, we show the dose-responsive induction of both PIM1 and EGR1 gene expression in UT-7 cells and of EGR1 in UT-7/EPO cells. The expression of EGR1 in UT-7/EPO cells in response to rHuEPO was comparable to the proliferative response measured by (3)H-thymidine incorporation and could be inhibited by serum from a patient with NAb-mediated PRCA in a dilution-dependent manner. Bioassays based on the induction of endogenous gene expression are comparable to current bioassays but are considerably quicker given that incubation time is decreased from 2-3 days to 50 min. Measurement of EGR1 gene expression in response to rHuEPO in UT-7/EPO cells offers a rapid, non-radioactive and automatable alternative to current assays for the detection of rHuEPO NAbs.

  19. Herschel SPIRE FTS telescope model correction

    CERN Document Server

    Hopwood, Rosalind; Polehampton, Edward T; Valtchanov, Ivan; Benielli, Dominique; Imhof, Peter; Lim, Tanya; Lu, Nanyao; Marchili, Nicola; Pearson, Chris P; Swinyard, Bruce M

    2014-01-01

    Emission from the Herschel telescope is the dominant source of radiation for the majority of SPIRE Fourier transform spectrometer (FTS) observations, despite the exceptionally low emissivity of the primary and secondary mirrors. Accurate modelling and removal of the telescope contribution is, therefore, an important and challenging aspect of FTS calibration and data reduction pipeline. A dust-contaminated telescope model with time invariant mirror emissivity was adopted before the Herschel launch. However, measured FTS spectra show a clear evolution of the telescope contribution over the mission and strong need for a correction to the standard telescope model in order to reduce residual background (of up to 7 Jy) in the final data products. Systematic changes in observations of dark sky, taken over the course of the mission, provide a measure of the evolution between observed telescope emission and the telescope model. These dark sky observations have been used to derive a time dependent correction to the tel...

  20. Aligning Astronomical Telescopes via Identification of Stars

    Science.gov (United States)

    Whorton, Mark

    2010-01-01

    A proposed method of automated, precise alignment of a ground-based astronomical telescope would eliminate the need for initial manual alignment. The method, based on automated identification of known stars and other celestial objects in the telescope field of view, would also eliminate the need for an initial estimate of the aiming direction. The method does not require any equipment other than a digital imaging device such as a charge-coupled-device digital imaging camera and control computers of the telescope and camera, all of which are standard components in professional astronomical telescope systems and in high-end amateur astronomical telescope systems. The method could be implemented in software running in the telescope or camera control computer or in an external computer communicating with the telescope pointing mount and camera control computers.

  1. The Special Solutions for the Equation ut=(eu(ux)2)x+P(u)ux+Q(u)%关于方程ut=(eu(ux)2)x+P(u)ux+Q(u)的一种解法

    Institute of Scientific and Technical Information of China (English)

    屈改珠

    2010-01-01

    研究了带有源项的非线性反应扩散方程ut=(eu(ux)2)x+P(u)ux+Q(U)特殊情况的解.利用二阶广义条件对称η=uxx+H(u)u2x+G(u)ux+F(u) 的方法,其中H(u),G(u),F(u)分别是u的光滑函数.得到了上述方程的几个解.该方法也可以用来解决其他偏微分方程.

  2. Recent developments for the Large Binocular Telescope Guiding Control Subsystem

    Science.gov (United States)

    Golota, T.; De La Peña, M. D.; Biddick, C.; Lesser, M.; Leibold, T.; Miller, D.; Meeks, R.; Hahn, T.; Storm, J.; Sargent, T.; Summers, D.; Hill, J.; Kraus, J.; Hooper, S.; Fisher, D.

    2014-07-01

    The Large Binocular Telescope (LBT) has eight Acquisition, Guiding, and wavefront Sensing Units (AGw units). They provide guiding and wavefront sensing capability at eight different locations at both direct and bent Gregorian focal stations. Recent additions of focal stations for PEPSI and MODS instruments doubled the number of focal stations in use including respective motion, camera controller server computers, and software infrastructure communicating with Guiding Control Subsystem (GCS). This paper describes the improvements made to the LBT GCS and explains how these changes have led to better maintainability and contributed to increased reliability. This paper also discusses the current GCS status and reviews potential upgrades to further improve its performance.

  3. Optical and system engineering in the development of a high-quality student telescope kit

    Science.gov (United States)

    Pompea, Stephen M.; Pfisterer, Richard N.; Ellis, Scott; Arion, Douglas N.; Fienberg, Richard Tresch; Smith, Thomas C.

    2010-07-01

    The Galileoscope student telescope kit was developed by a volunteer team of astronomers, science education experts, and optical engineers in conjunction with the International Year of Astronomy 2009. This refracting telescope is in production with over 180,000 units produced and distributed with 25,000 units in production. The telescope was designed to be able to resolve the rings of Saturn and to be used in urban areas. The telescope system requirements, performance metrics, and architecture were established after an analysis of current inexpensive telescopes and student telescope kits. The optical design approaches used in the various prototypes and the optical system engineering tradeoffs will be described. Risk analysis, risk management, and change management were critical as was cost management since the final product was to cost around 15 (but had to perform as well as 100 telescopes). In the system engineering of the Galileoscope a variety of analysis and testing approaches were used, including stray light design and analysis using the powerful optical analysis program FRED.

  4. Progress on Space Solar Telescope in 2002-2004

    Institute of Scientific and Technical Information of China (English)

    AI Guoxiang; YAN Yihua; JIN Shengzhen

    2004-01-01

    The progress on Chinese Space Solar Telescope (SST) in 2002-2004 is introduced. The documentations on plans and outlines based on the standards of Chinese aerospace industry for SST mission has been fulfilled. The key technical problems of SST satellite platform and payloads are tackled during pre-study stage of the mission. The laboratory assembly and calibration of the main optical telescope of 1.2 m spherical mirror and 1 m plain mirror have been carried out with the accuracy of λ/40 and λ/30, respectively. The prototype at 17.1 nm for extreme ultraviolet telescope is under development and manufacture with a diameter of 13 cm. Its primary and secondary mirrors have a manufacturing error of 5nm with a roughness degree of less than 0.5 nm and a multiplayer reflection factor of better than 20%. The on-board scientific data processing unit has been developed. Prototypes for other payloads such as H and white light telescope, wide band spectroscopy in high energy and solar and interplanetary radio spectrometer have been developed accordingly.

  5. An EUDET/AIDA Pixel Beam Telescope for Detector Development

    CERN Document Server

    Rubinskiy, I

    2015-01-01

    A high resolution (σ∼2μm) beam telescope based on monolithic active pixel sensors (MAPS) was developed within the EUDET collaboration. The telescope consists of six monolithic active pixel sensor planes (Mimosa26) with a pixel pitch of 18.4 \\mu m and thinned down to 50 \\mu m. The excellent resolution, readout rate and DAQ integration capabilities made the telescope a primary test beam tool for many groups including several CERN based experiments. Within the European detector infrastructure project AIDA the test beam telescope is being further extended in terms of cooling and powering infrastructure, read-out speed, area of acceptance, and precision. In order to provide a system optimized for the different requirements by the user community a combination of various state-of-the-art pixel technologies is foreseen. Furthermore, new central dead-time-free trigger logic unit (TLU) has been developed to provide LHC-speed response with one-trigger-per-particle operating mode and a synchronous clock for all conn...

  6. Status of the Cherenkov Telescope Array's Large Size Telescopes

    CERN Document Server

    Cortina, J

    2015-01-01

    The Cherenkov Telescope Array (CTA) observatory, will be deployed over two sites in the two hemispheres. Both sites will be equipped with four Large Size Telescopes (LSTs), which are crucial to achieve the science goals of CTA in the 20-200 GeV energy range. Each LST is equipped with a primary tessellated mirror dish of 23 m diameter, supported by a structure made mainly of carbon fibre reinforced plastic tubes and aluminum joints. This solution guarantees light weight (around 100 tons), essential for fast repositioning to any position in the sky in <20 seconds. The camera is composed of 1855 PMTs and embeds the control, readout and trigger electronics. The detailed design is now complete and production of the first LST, which will serve as a prototype for the remaining seven, is well underway. In 2016 the first LST will be installed at the Roque de los Muchachos Observatory on the Canary island of La Palma (Spain). In this talk we will outline the technical solutions adopted to fulfill the design requirem...

  7. Influence of kind of trees on flowering and yielding of sour cherry cultivar Łutówka

    Directory of Open Access Journals (Sweden)

    Stanisław Wociór

    2012-12-01

    Full Text Available In no examined years of the studies were found no significant differences of flowering intensity between the ownoroots trees of the cultivar Łutówka and trees budded on Prunus mahaleb. The kind of trees clearly, but not significantly, affected fruit mass. The growth of the ownroot "in vitro" trees were significantly less than the trees budded on Prunus mahaleb seedling. Fruit set and yielding of the own root trees were higher, but only in one year of study significantly higher.

  8. SpRoUTS (Space Robot Universal Truss System): Reversible Robotic Assembly of Deployable Truss Structures of Reconfigurable Length

    Science.gov (United States)

    Jenett, Benjamin; Cellucci, Daniel; Cheung, Kenneth

    2015-01-01

    Automatic deployment of structures has been a focus of much academic and industrial work on infrastructure applications and robotics in general. This paper presents a robotic truss assembler designed for space applications - the Space Robot Universal Truss System (SpRoUTS) - that reversibly assembles a truss from a feedstock of hinged andflat-packed components, by folding the sides of each component up and locking onto the assembled structure. We describe the design and implementation of the robot and show that the assembled truss compares favorably with prior truss deployment systems.

  9. Un acercamiento comparativo al pensamiento utópico y su relación con el 15M

    Directory of Open Access Journals (Sweden)

    Noemí Morejón Llamas

    2015-08-01

    Full Text Available El movimiento de Indignados que surge en España en mayo de 2011 con el fenómeno 15M supone el revivir de la utopía política en el siglo XXI. En el actual contexto de crisis económica y desgaste político los ciudadanos deciden reagruparse para exponer un discurso utópico y emocional. A través de la utopía política que proponen reavivan discursos pasados que defienden la libertad, la igualdad, la fraternidad y la esperanza en la bondad del ser humano. 

  10. Scientific Potential of Einstein Telescope

    CERN Document Server

    Sathyaprakash, B; Acernese, F; Andersson, P Amaro-Seoane N; Arun, K; Barone, F; Barr, B; Barsuglia, M; Beveridge, M Beker N; Birindelli, S; Bose, S; Bosi, L; Braccini, S; Bradaschia, C; Bulik, T; Calloni, E; Cella, G; Mottin, E Chassande; Chelkowski, S; Chincarini, A; Clark, J; Coccia, E; Colacino, C; Colas, J; Cumming, A; Cunningham, L; Cuoco, E; Danilishin, S; Danzmann, K; Salvo, R De; Dent, T; Rosa, R De; Fiore, L Di; Virgilio, A Di; Doets, M; Fafone, V; Falferi, P; Flaminio, R; Franc, J; Frasconi, F; Freise, A; Friedrich, D; Fulda, P; Gair, J; Gemme, G; Genin, E; Gennai, A; Giazotto, A; Glampedakis, K; Gräf, C; Granata, M; Grote, H; Guidi, G; Gurkovsky, A; Hammond, G; Hannam, M; Harms, J; Heinert, D; Hendry, M; Heng, I; Hennes, E; Hild, S; Hough, J; Husa, S; Huttner, S; Jones, G; Khalili, F; Kokeyama, K; Kokkotas, K; Krishnan, B; Li, T G F; Lorenzini, M; Lück, H; Majorana, E; Mandel, I; Mandic, V; Mantovani, M; Martin, I; Michel, C; Minenkov, Y; Morgado, N; Mosca, S; Mours, B; Müller--Ebhardt, H; Murray, P; Nawrodt, R; Nelson, J; Oshaughnessy, R; Ott, C D; Palomba, C; Paoli, A; Parguez, G; Pasqualetti, A; Passaquieti, R; Passuello, D; Pinard, L; Plastino, W; Poggiani, R; Popolizio, P; Prato, M; Punturo, M; Puppo, P; Rabeling, D; Racz, I; Rapagnani, P; Read, J; Regimbau, T; Rehbein, H; Reid, S; Rezzolla, L; Ricci, F; Richard, F; Rocchi, A; Rowan, S; Rüdiger, A; Santamaría, L; Sassolas, B; Schnabe, R; Schwarz, C; Seidel, P; Sintes, A; Somiya, K; Speirits, F; Strain, K; Strigin, S; Sutton, P; Tarabrin, S; Thüring, A; Brand, J van den; Veggel, M van; Broeck, C van den; Vecchio, A; Veitch, J; Vetrano, F; Vicere, A; Vyatchanin, S; Willke, B; Woan, G; Yamamoto, K

    2011-01-01

    Einstein gravitational-wave Telescope (ET) is a design study funded by the European Commission to explore the technological challenges of and scientific benefits from building a third generation gravitational wave detector. The three-year study, which concluded earlier this year, has formulated the conceptual design of an observatory that can support the implementation of new technology for the next two to three decades. The goal of this talk is to introduce the audience to the overall aims and objectives of the project and to enumerate ET's potential to influence our understanding of fundamental physics, astrophysics and cosmology.

  11. Detectors for the space telescope

    Science.gov (United States)

    Kelsall, T.

    1978-01-01

    This review of Space Telescope (ST) detectors is divided into two parts. The first part gives short summaries of detector programs carried out during the final planning stage (Phase B) of the ST and discusses such detectors as Photicon, the MAMA detectors, the CODACON, the University of Maryland ICCD, the Goddard Space Flight Center ICCD, and the 70 mm SEC TV sensor. The second part describes the detectors selected for the first ST flight, including the wide field/planetary camera, the faint object and high resolution spectrographs, and the high speed photometer.

  12. Cosmography with the Einstein Telescope

    CERN Document Server

    Sathyaprakash, B S; Broeck, Chris Van Den

    2009-01-01

    Einstein Telescope (ET) is a 3rd generation gravitational-wave (GW) detector that is currently undergoing a design study. ET can detect millions of compact binary mergers up to redshifts 2-8. A small fraction of mergers might be observed in coincidence as gamma-ray bursts, helping to measure both the luminosity distance and red-shift to the source. By fitting these measured values to a cosmological model, it should be possible to accurately infer the dark energy equation-of-state, dark matter and dark energy density parameters. ET could, therefore, herald a new era in cosmology.

  13. The Advanced Compton Telescope Mission

    CERN Document Server

    Boggs, S E; Ryan, J; Aprile, E; Gehrels, N; Kippen, M; Leising, M; Oberlack, U; Wunderer, C; Zych, A; Bloser, P; Harris, M; Hoover, A; Klimenk, A; Kocevski, D; McConnell, M; Milne, P; Novikova, E I; Phlips, B; Polsen, M; Sturner, S; Tournear, D; Weidenspointner, G; Wulf, E; Zoglauer, A; Baring, M; Beacom, J; Bildsten, L; Dermer, C; Hartmann, D; Hernanz, M; Smith, D; Starrfield, S; Boggs, Steven E.; Kurfess, James; Ryan, James; Aprile, Elena; Gehrels, Neil; Kippen, Marc; Leising, Mark; Oberlack, Uwe; Wunderer, Cornelia; Zych, Allen; Bloser, Peter; Harris, Michael; Hoover, Andrew; Klimenk, Alexei; Kocevski, Dan; Connell, Mark Mc; Milne, Peter; Novikova, Elena I.; Phlips, Bernard; Polsen, Mark; Sturner, Steven; Tournear, Derek; Weidenspointner, Georg; Wulf, Eric; Zoglauer, Andreas; Baring, Matthew; Beacom, John; Bildsten, Lars; Dermer, Charles; Hartmann, Dieter; Hernanz, Margarita; Smith, David; Starrfield, Sumner

    2006-01-01

    The Advanced Compton Telescope (ACT), the next major step in gamma-ray astronomy, will probe the fires where chemical elements are formed by enabling high-resolution spectroscopy of nuclear emission from supernova explosions. During the past two years, our collaboration has been undertaking a NASA mission concept study for ACT. This study was designed to (1) transform the key scientific objectives into specific instrument requirements, (2) to identify the most promising technologies to meet those requirements, and (3) to design a viable mission concept for this instrument. We present the results of this study, including scientific goals and expected performance, mission design, and technology recommendations.

  14. O pluralismo pós-utópico da arte

    Directory of Open Access Journals (Sweden)

    Lucia Santaella

    2009-01-01

    Full Text Available Em meados dos anos 1980, alguns autores, entre eles Arthur Danto, defenderam ideias que convergiam para a proclamação do fim da arte. Esse período histórico coincidia com a explosão dos estilos pós-modernos nas artes e com os debates filosóficos e culturais da pós-modernidade. Por "fim da arte" os autores pretendiam sinalizar que, nos anos 1960, uma espécie de fechamento ocorreu no desenvolvimento histórico da arte. Uma era de impressionante criatividade, que durou seis séculos no Ocidente, chegou a um fim de modo que qualquer arte que pudesse vir a existir daí para frente deveria estar marcada por um caráter pós-histórico. Esse caráter coincidia com a descrença nas utopias. Estas corriam de modo mais ou menos subterrâneo, mais ou menos explícito por todos os movimentos vanguardistas, então crepusculares. Nesse contexto, o argumento que este ensaio pretende defender é que, longe de indicar ausência de sentido crítico, engajamento ético ou militância política, o criticado "vale tudo" pós-moderno estava sinalizando a emergência de um novo tempo pós-utópico na cultura e nas artes. Na falta de um nome melhor, esse novo tempo tem sido chamado de contemporaneidade e arte contemporânea cuja característica primordial encontrase na avalanche pluralista e radicalmente diversificada de tendências estéticas que tem provocado profundas mudanças no papel dos curadores, na natureza dos museus e na posição contingente da crítica.During the mid-80s, authors like Arthur Danto have championed ideas proclaiming the end of art. That historical period concured with the boom of post-modernist artistic styles and with the philosophical and cultural debates dealing with post-modernity. By "the end of art" those authors intended to mean that some sort of closure in the historical evolution of art had taken place in the 60s. A time of impressive creativity, having lasted for six centuries in the West, had reached its demise, and any

  15. Mineral Physics Research on Earth's Core and UTeach Outreach Activities at UT Austin

    Science.gov (United States)

    Lin, J.; Wheat, A. J.

    2011-12-01

    questions the young students had about college life and studies. Outreach benefits include effective and organized collaborations with the UTeach program, which prepares undergraduates at UT-Austin to teach secondary science courses, as well as positive connections made with Austin-area science teachers, providing them with alternative knowledge and experience to share with their students in the classroom. The CAREER award offers an excellent venue to connect the PI's research and educational activities, and has made constructive impacts on the PI's career development and on his continuation in this frontier research. The students who visited the lab wrote thank you cards, some expressing great interest in being scientists, geophysicists, and chemical engineers, as well as drawings of diamond anvil cells and the pressure/area relationship, showing excellent comprehension of the subject matter. Program improvements may lie in also outreaching to teachers to create stronger relationships in an effort to enrich curricula and keep students aware of research and degree options as the time to enter college nears.

  16. Isolation and Characterization of a Novel CO2-Tolerant Lactobacillus Strain from Crystal Geyser, UT

    Science.gov (United States)

    Santillan, E. U.; Major, J. R.; Omelon, C. R.; Shanahan, T. M.; Bennett, P.

    2013-12-01

    Capnophiles are microbes that grow in CO2 enriched environments. Cultured capnophiles generally, grow in 2 to 25% CO2, or 0.02 to 0.25 atm. When CO2 is sequestered in deep saline aquifers, the newly created high CO2 environment may select for capnophlic organisms. In this study, a capnophile was isolated from Crystal Geyser, a CO2 spring along the Little Grand Wash Fault, UT, a site being investigated as an analogue to CO2 sequestration. Crystal Geyser periodically erupts with CO2 charged water, indicating the presence of very high CO2 pressures below the subsurface, similar to sequestration conditions. Biomass was sampled by pumping springwater from approximately 10 m below the surface through filters. Filters were immediately placed in selective media within pressure vessels where they were pressurized to 10 atm in the field. Subsequent recultures produced an isolate, designated CG-1, that is most closely (99%) related to Lactobacillus casei on the strain level. CG-1 grows in tryptic soy broth, in PCO2 ranging from 0 atm to 10 atm, 40 times higher than pressures of previously cultured capnophiles. At 25 atm, growth is inhibited though survival can be as long as 5 days. At 50 atm, survival is poor, with sterilization occurring by 24 hours. Growth is optimal between pH values of 6 to 8, though sluggish if no CO2 is present. Its optimal salinity is 0.25 M NaCl though growth is observed ranging from 0 to 1 M NaCl. Growth is observed between 25o to 45o C, but optimal at 25oC. It consumes long-chained carbon molecules such as glucose, sucrose, and crude oil, and exhibits poor growth when supplied with lactate, acetate, formate, and pyruvate. The organism likely performs lactic acid fermentation as it requires no electron acceptors for growth and produces no acid, gas, and sulfide in triple sugar iron agar slants. CG-1 also expresses a variety of lipids, most notably cyclopropyl C19 (cycC19), or lactobacillic acid, characteristic of organisms belonging to the

  17. The Large Area Telescope on the Fermi Gamma-ray Space Telescope Mission

    Energy Technology Data Exchange (ETDEWEB)

    Atwood, W.B.; /UC, Santa Cruz; Abdo, Aous A.; /Naval Research Lab, Wash., D.C.; Ackermann, M.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Anderson, B. /UC, Santa Cruz; Axelsson, M.; /Stockholm U.; Baldini, L.; /INFN, Pisa; Ballet, J.; /DAPNIA, Saclay; Band, D.L.; /NASA, Goddard /NASA, Goddard; Barbiellini, Guido; /INFN, Trieste /Trieste U.; Bartelt, J.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bastieri, Denis; /INFN, Padua /Padua U.; Baughman, B.M.; /Ohio State U.; Bechtol, K.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bederede, D.; /DAPNIA, Saclay; Bellardi, F.; /INFN, Pisa; Bellazzini, R.; /INFN, Pisa; Berenji, B.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; Bignami, G.F.; /Pavia U.; Bisello, D.; /INFN, Padua /Padua U.; Bissaldi, E.; /Garching, Max Planck Inst., MPE; Blandford, R.D.; /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Perugia /Perugia U. /NASA, Goddard /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /INFN, Pisa /INFN, Pisa /Bari U. /INFN, Bari /Ecole Polytechnique /Washington U., Seattle /INFN, Padua /Padua U. /Bari U. /INFN, Bari /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /IASF, Milan /IASF, Milan /Kalmar U. /Royal Inst. Tech., Stockholm /DAPNIA, Saclay /ASI, Rome /INFN, Pisa /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /George Mason U. /Naval Research Lab, Wash., D.C. /NASA, Goddard /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /DAPNIA, Saclay /NASA, Goddard /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Montpellier U. /Stanford U., HEPL /KIPAC, Menlo Park /Stanford U., Phys. Dept.; /more authors..

    2009-05-15

    The Large Area Telescope (Fermi/LAT, hereafter LAT), the primary instrument on the Fermi Gamma-ray Space Telescope (Fermi) mission, is an imaging, wide field-of-view (FoV), high-energy {gamma}-ray telescope, covering the energy range from below 20 MeV to more than 300 GeV. The LAT was built by an international collaboration with contributions from space agencies, high-energy particle physics institutes, and universities in France, Italy, Japan, Sweden, and the United States. This paper describes the LAT, its preflight expected performance, and summarizes the key science objectives that will be addressed. On-orbit performance will be presented in detail in a subsequent paper. The LAT is a pair-conversion telescope with a precision tracker and calorimeter, each consisting of a 4 x 4 array of 16 modules, a segmented anticoincidence detector that covers the tracker array, and a programmable trigger and data acquisition system. Each tracker module has a vertical stack of 18 (x, y) tracking planes, including two layers (x and y) of single-sided silicon strip detectors and high-Z converter material (tungsten) per tray. Every calorimeter module has 96 CsI(Tl) crystals, arranged in an eight-layer hodoscopic configuration with a total depth of 8.6 radiation lengths, giving both longitudinal and transverse information about the energy deposition pattern. The calorimeter's depth and segmentation enable the high-energy reach of the LAT and contribute significantly to background rejection. The aspect ratio of the tracker (height/width) is 0.4, allowing a large FoV (2.4 sr) and ensuring that most pair-conversion showers initiated in the tracker will pass into the calorimeter for energy measurement. Data obtained with the LAT are intended to (1) permit rapid notification of high-energy {gamma}-ray bursts and transients and facilitate monitoring of variable sources, (2) yield an extensive catalog of several thousand high-energy sources obtained from an all-sky survey, (3

  18. The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-κB pathways in LPS-stimulated Kupffer cells.

    Science.gov (United States)

    Liu, Liang Ming; Liang, Dong Yu; Ye, Chang Gen; Tu, Wen Juan; Zhu, Tong

    2015-01-01

    The urotensin II (UII)/UII receptor (UT) system is closely related to immune inflammation. In acute liver failure (ALF), the UII/UT system can promote the production and release of proinflammatory cytokines, inducing an inflammatory injury response in liver tissue. However, the mechanism by which the hepatic UII/UT system promotes proinflammatory cytokine production and release is not clear. To solve this problem, we used primary Kupffer cells (KCs) as the model system in the current study. The results showed that after lipopolysaccharide (LPS) stimulation, KCs showed significantly increased expression and release of UII/UT and proinflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β). Pretreatment with urantide, which is a UT receptor antagonist, significantly inhibited the LPS-stimulated expression and release of UII/UT, TNF-α, and IL-1β by KCs. In addition, LPS stimulation induced nuclear p38 mitogen-activated protein kinase (MAPK) protein phosphorylation and expression of the nuclear nuclear factor κB (NF-κB) p65 subunit in KCs and enhanced the binding activity of NF-κB to DNA molecules, whereas urantide pretreatment significantly inhibited the LPS-stimulated nuclear expression and activity of these molecules in KCs. Therefore, our conclusion is that the UII/UT system mediates LPS-stimulated production and release of proinflammatory cytokine by KCs, and this mediating effect at least partially relies on the inflammatory signaling pathway molecules p38 MAPK and NF-κB.

  19. Corrector systems for cassegrain telescopes.

    Science.gov (United States)

    Wilson, R N

    1968-02-01

    Most modern reflecting telescopes have relative apertures of about f/3 and f/8 for the primary and first secondary foci in accordance with the suggestions of Bowen. The angular field which can be used at the first secondary focus is limited by the size of available plates for large instruments but can approach +/-1 degrees for smaller systems. The factors influencing the choice of the field corrector system in the first secondary focus are discussed. It is an important point whether the Ritchey-Chrétien form of the mirrors is strictly maintained-giving an optimum field without the corrector-or whether the aspheric constants are allowed to vary as free parameters. The differences are small but significant. The performance of a number of secondary focus correctors consisting of one, two, and three elements is discussed, spot diagrams being given in each case. Systems with fixed Ritchey-Chrétien mirror constants are inferior to those with free mirror constants. Test methods for the manufacture of the mirrors of telescopes of this type are compared. A doublet type corrector is suitable for compensation testing of primary mirrors or for secondaries tested from the back, but the testing of the latter from the front is more difficult. Several possible techniques are discussed.

  20. Origins Space Telescope: Community Participation

    Science.gov (United States)

    Carey, Sean J.; Origins Space Telescope Study Team

    2017-01-01

    The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, a study in development by NASA in preparation for the 2020 Astronomy and Astrophysics Decadal Survey. Origins is planned to be a large aperture, actively-cooled telescope covering a wide span of the mid- to far-infrared spectrum. Its imagers and spectrographs will enable a variety of surveys of the sky that will discover and characterize the most distant galaxies, Milky-Way, exoplanets, and the outer reaches of our Solar system. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. This poster will outline the ways in which the astronomical community can participate in the STDT activities and a summary of tools that are currently available or are planned for the community during the study. The Science and Technology Definition Team (STDT) would like to hear your science needs and ideas for this mission. The team can be contacted at firsurveyor_info@lists.ipac.caltech.edu.

  1. Far Ultraviolot Space Telescope (FAUST)

    Science.gov (United States)

    Bowyer, S.

    1988-01-01

    The Far Ultraviolet Space Telescope is a compact, wide field-of-view, far ultraviolet instrument designed for observations of extended and point sources of astronomical interest. It was originally used in sounding rocket work by both French and American investigators. The instrument was modified for flight on the space shuttle and flew on the Spacelab 1 mission as a joint effort between the Laboratoire d'Astronomie Spatiale and the University of California, Berkeley. The prime experiment objective of this telescope on the Atmospheric Laboratory Applications and Science (ATLAS 1) NASA mission is to observe faint astronomical sources in the far ultraviolet with sensitivities far higher than previously available. The experiment will cover the 1300 to 1800 A band, which is inaccessible to observers on earth. The observing program during the mission consists of obtaining deep sky images during spacecraft nighttime. The targets will include hot stars and nebulae in our own galaxy, faint diffuse galactic features similar to the cirrus clouds seen by the Infrared Astronomical Satellite (IRAS), large nearby galaxies, nearby clusters of galaxies, and objects of cosmological interest such as quasars and the diffuse far ultraviolet background.

  2. Origins Space Telescope: Study Plan

    Science.gov (United States)

    Cooray, Asantha R.; Origins Space Telescope Study Team

    2017-01-01

    The Origins Space Telescope (OST) is the mission concept for the Far-Infrared Surveyor, a study in development by NASA in preparation for the 2020 Astronomy and Astrophysics Decadal Survey. Origins is planned to be a large aperture, actively-cooled telescope covering a wide span of the mid- to far-infrared spectrum. Its spectrographs will enable 3D surveys of the sky that will discover and characterize the most distant galaxies, Milky-Way, exoplanets, and the outer reaches of our Solar system. Origins will enable flagship-quality general observing programs led by the astronomical community in the 2030s. The Science and Technology Definition Team (STDT) would like to hear your science needs and ideas for this mission. The team can be contacted at firsurveyor_info@lists.ipac.caltech.edu. This presentation will provide a summary of the OST STDT, the OST Study Team based at NASA Goddard Space Flight Center, study partners, and the advisory panel to the study. This presentation will also summarize recent activities, including the process used to reach a decision on the mission architecture, the identification of key science drivers, and the key study milestones between 2017 and 2020.

  3. ANTARES: An Undersea Neutrino telescope

    CERN Multimedia

    2002-01-01

    The ANTARES (Astronomy with a Neutrino Telescope and ${Abyss}$ environmental RESearch) deep-sea neutrino telescope is designed to search for neutrinos of astrophysical origin. Neutrinos are unique probes of the high energy universe; being neutral they are not deflected by magnetic fields and interacting weakly they can readily escape from the densest regions of the universe. Potential sources of neutrino are galactic (e.g supernova remnants, micro-quasars) and extra-galactic (e.g active galactic nuclei, gamma-ray bursters). Annihilation of dark matter particles in the Sun or Galactic Centre is another well motivated potential source of extra terrestrial neutrinos. The ANTARES detector is located 40 km off the coast of Toulon (France) at a depth of 2475m in the Mediterranean Sea. Being located in the Northern hemisphere it studies the Southern sky and in particular has the Galactic Centre in its field of view. Since 2006, the detector has operated continuously in a partial configuration. The detector was compl...

  4. Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway

    Science.gov (United States)

    Sun, Yi; Lau, Chi-Wai; Jia, Yingli; Li, Yingjie; Wang, Weiling; Ran, Jianhua; Li, Fei; Huang, Yu; Zhou, Hong; Yang, Baoxue

    2016-01-01

    Mammalian urea transporters (UTs), UT-A and UT-B, are best known for their role in urine concentration. UT-B is especially distributed in multiple extrarenal tissues with abundant expression in vascular endothelium, but little is known about its role in vascular function. The present study investigated the physiological significance of UT-B in regulating vasorelaxations and blood pressure. UT-B deletion in mice or treatment with UT-B inhibitor PU-14 in Wistar-Kyoto rats (WKYs) and spontaneous hypertensive rats (SHRs) reduced blood pressure. Acetylcholine-induced vasorelaxation was significantly augmented in aortas from UT-B null mice. PU-14 concentration-dependently produced endothelium-dependent relaxations in thoracic aortas and mesenteric arteries from both mice and rats and the relaxations were abolished by Nω-nitro-L-arginine methyl ester. Both expression and phosphorylation of endothelial nitric oxide synthase (eNOS) were up-regulated and expression of arginase I was down-regulated when UT-B was inhibited both in vivo and in vitro. PU-14 induced endothelium-dependent relaxations to a similar degree in aortas from 12 weeks old SHRs or WKYs. In summary, here we report for the first time that inhibition of UT-B plays an important role in regulating vasorelaxations and blood pressure via up-regulation of L-arginine-eNOS-NO pathway, and it may become another potential therapeutic target for the treatment of hypertension. PMID:26739766

  5. Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway.

    Science.gov (United States)

    Sun, Yi; Lau, Chi-Wai; Jia, Yingli; Li, Yingjie; Wang, Weiling; Ran, Jianhua; Li, Fei; Huang, Yu; Zhou, Hong; Yang, Baoxue

    2016-01-07

    Mammalian urea transporters (UTs), UT-A and UT-B, are best known for their role in urine concentration. UT-B is especially distributed in multiple extrarenal tissues with abundant expression in vascular endothelium, but little is known about its role in vascular function. The present study investigated the physiological significance of UT-B in regulating vasorelaxations and blood pressure. UT-B deletion in mice or treatment with UT-B inhibitor PU-14 in Wistar-Kyoto rats (WKYs) and spontaneous hypertensive rats (SHRs) reduced blood pressure. Acetylcholine-induced vasorelaxation was significantly augmented in aortas from UT-B null mice. PU-14 concentration-dependently produced endothelium-dependent relaxations in thoracic aortas and mesenteric arteries from both mice and rats and the relaxations were abolished by N(ω)-nitro-L-arginine methyl ester. Both expression and phosphorylation of endothelial nitric oxide synthase (eNOS) were up-regulated and expression of arginase I was down-regulated when UT-B was inhibited both in vivo and in vitro. PU-14 induced endothelium-dependent relaxations to a similar degree in aortas from 12 weeks old SHRs or WKYs. In summary, here we report for the first time that inhibition of UT-B plays an important role in regulating vasorelaxations and blood pressure via up-regulation of L-arginine-eNOS-NO pathway, and it may become another potential therapeutic target for the treatment of hypertension.

  6. Kinematic optimization of upgrade to the Hobby-Eberly Telescope through novel use of commercially available three-dimensional CAD package

    Science.gov (United States)

    Wedeking, Gregory A.; Zierer, Joseph J.; Jackson, John R.

    2010-07-01

    The University of Texas, Center for Electromechanics (UT-CEM) is making a major upgrade to the robotic tracking system on the Hobby Eberly Telescope (HET) as part of theWide Field Upgrade (WFU). The upgrade focuses on a seven-fold increase in payload and necessitated a complete redesign of all tracker supporting structure and motion control systems, including the tracker bridge, ten drive systems, carriage frames, a hexapod, and many other subsystems. The cost and sensitivity of the scientific payload, coupled with the tracker system mass increase, necessitated major upgrades to personnel and hardware safety systems. To optimize kinematic design of the entire tracker, UT-CEM developed novel uses of constraints and drivers to interface with a commercially available CAD package (SolidWorks). For example, to optimize volume usage and minimize obscuration, the CAD software was exercised to accurately determine tracker/hexapod operational space needed to meet science requirements. To verify hexapod controller models, actuator travel requirements were graphically measured and compared to well defined equations of motion for Stewart platforms. To ensure critical hardware safety during various failure modes, UT-CEM engineers developed Visual Basic drivers to interface with the CAD software and quickly tabulate distance measurements between critical pieces of optical hardware and adjacent components for thousands of possible hexapod configurations. These advances and techniques, applicable to any challenging robotic system design, are documented and describe new ways to use commercially available software tools to more clearly define hardware requirements and help insure safe operation.

  7. Merz telescopes a global heritage worth preserving

    CERN Document Server

    2017-01-01

    This book comprises a fascinating collection of contributions on the Merz telescopes in Italy that collectively offer the first survey on historical large refracting telescopes in the country, drawing on original documents and photographs. It opens with a general introduction on the importance of Merz telescopes in the history of astronomy and analyses of the local and international contexts in which the telescopes were made. After examination of an example of the interaction between the maker and the astronomer in the construction and maintenance of these refractors, the history of the Merz telescopes at the main Italian observatories in the nineteenth century is described in detail. Expert testimony is also provided on how these telescopes were successfully used until the second half of the twentieth century for research purposes, thus proving their excellent optical qualities.

  8. Launch Will Create a Radio Telescope Larger than Earth

    Science.gov (United States)

    . This includes the National Science Foundation's Very Long Baseline Array (VLBA), an array of 10 telescopes spanning the United States from Hawaii to Saint Croix; NASA's Deep Space Network (DSN) sites in California, Spain, and Australia; the European VLBI Network, more than a dozen telescopes ranging from the United Kingdom to China; a Southern Hemisphere array of telescopes stretching from eastern Australia to South Africa; and Japan's network of domestic radio telescopes. In the United States, NASA is funding critical roles in the VSOP mission at both JPL and NRAO. JPL has built an array of three new tracking stations at its DSN sites in Goldstone, CA; Madrid, Spain; and near Canberra, Australia. A large existing tracking station at each of these sites has also been converted to an extremely sensitive radio telescope for simultaneous observations with the satellite. JPL also is providing precision orbit determination, scientific and operational planning support to the Japanese, and advice to U.S. astronomers who wish to observe with the satellite. NRAO is building a new tracking station at Green Bank, WV; contributing observing time on the VLBA array of telescopes; modifying existing data analysis hardware and software, and aiding astronomers with the analysis of the VSOP data. Much of the observational data will be processed at NRAO's facility in Socorro, NM, using the VLBA Correlator, a special purpose high-performance computer designed to process VLBI data. VSOP is the culmination of many years of planning and work by scientists and engineers around the world. Tests using NASA's Tracking and Data Relay Satellite System (TDRSS) proved the feasibility of space VLBI in 1986. Just last year, those old data were used again to test successfully the data-reduction facilities for VSOP. JPL manages the U.S. Space Very Long Baseline Interferometry project for NASA's Office of Space Science, Washington, DC. The VLBA, headquartered in Socorro, NM, is part of the National Radio

  9. ANTARES: The first undersea neutrino telescope

    Science.gov (United States)

    Ageron, M.; Aguilar, J. A.; Al Samarai, I.; Albert, A.; Ameli, F.; André, M.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Arnaud, K.; Aslanides, E.; Assis Jesus, A. C.; Astraatmadja, T.; Aubert, J.-J.; Auer, R.; Barbarito, E.; Baret, B.; Basa, S.; Bazzotti, M.; Becherini, Y.; Beltramelli, J.; Bersani, A.; Bertin, V.; Beurthey, S.; Biagi, S.; Bigongiari, C.; Billault, M.; Blaes, R.; Bogazzi, C.; de Botton, N.; Bou-Cabo, M.; Boudahef, B.; Bouwhuis, M. C.; Brown, A. M.; Brunner, J.; Busto, J.; Caillat, L.; Calzas, A.; Camarena, F.; Capone, A.; Caponetto, L.; Cârloganu, C.; Carminati, G.; Carmona, E.; Carr, J.; Carton, P. H.; Cassano, B.; Castorina, E.; Cecchini, S.; Ceres, A.; Chaleil, Th.; Charvis, Ph.; Chauchot, P.; Chiarusi, T.; Circella, M.; Compère, C.; Coniglione, R.; Coppolani, X.; Cosquer, A.; Costantini, H.; Cottini, N.; Coyle, P.; Cuneo, S.; Curtil, C.; D'Amato, C.; Damy, G.; van Dantzig, R.; de Bonis, G.; Decock, G.; Decowski, M. P.; Dekeyser, I.; Delagnes, E.; Desages-Ardellier, F.; Deschamps, A.; Destelle, J.-J.; di Maria, F.; Dinkespiler, B.; Distefano, C.; Dominique, J.-L.; Donzaud, C.; Dornic, D.; Dorosti, Q.; Drogou, J.-F.; Drouhin, D.; Druillole, F.; Durand, D.; Durand, R.; Eberl, T.; Emanuele, U.; Engelen, J. J.; Ernenwein, J.-P.; Escoffier, S.; Falchini, E.; Favard, S.; Fehr, F.; Feinstein, F.; Ferri, M.; Ferry, S.; Fiorello, C.; Flaminio, V.; Folger, F.; Fritsch, U.; Fuda, J.-L.; Galatá, S.; Galeotti, S.; Gay, P.; Gensolen, F.; Giacomelli, G.; Gojak, C.; Gómez-González, J. P.; Goret, Ph.; Graf, K.; Guillard, G.; Halladjian, G.; Hallewell, G.; van Haren, H.; Hartmann, B.; Heijboer, A. J.; Heine, E.; Hello, Y.; Henry, S.; Hernández-Rey, J. J.; Herold, B.; Hößl, J.; Hogenbirk, J.; Hsu, C. C.; Hubbard, J. R.; Jaquet, M.; Jaspers, M.; de Jong, M.; Jourde, D.; Kadler, M.; Kalantar-Nayestanaki, N.; Kalekin, O.; Kappes, A.; Karg, T.; Karkar, S.; Karolak, M.; Katz, U.; Keller, P.; Kestener, P.; Kok, E.; Kok, H.; Kooijman, P.; Kopper, C.; Kouchner, A.; Kretschmer, W.; Kruijer, A.; Kuch, S.; Kulikovskiy, V.; Lachartre, D.; Lafoux, H.; Lagier, P.; Lahmann, R.; Lahonde-Hamdoun, C.; Lamare, P.; Lambard, G.; Languillat, J.-C.; Larosa, G.; Lavalle, J.; Le Guen, Y.; Le Provost, H.; Levansuu, A.; Lefèvre, D.; Legou, T.; Lelaizant, G.; Lévéque, C.; Lim, G.; Lo Presti, D.; Loehner, H.; Loucatos, S.; Louis, F.; Lucarelli, F.; Lyashuk, V.; Magnier, P.; Mangano, S.; Marcel, A.; Marcelin, M.; Margiotta, A.; Martinez-Mora, J. A.; Masullo, R.; Mazéas, F.; Mazure, A.; Meli, A.; Melissas, M.; Migneco, E.; Mongelli, M.; Montaruli, T.; Morganti, M.; Moscoso, L.; Motz, H.; Musumeci, M.; Naumann, C.; Naumann-Godo, M.; Neff, M.; Niess, V.; Nooren, G. J. L.; Oberski, J. E. J.; Olivetto, C.; Palanque-Delabrouille, N.; Palioselitis, D.; Papaleo, R.; Păvălaş, G. E.; Payet, K.; Payre, P.; Peek, H.; Petrovic, J.; Piattelli, P.; Picot-Clemente, N.; Picq, C.; Piret, Y.; Poinsignon, J.; Popa, V.; Pradier, T.; Presani, E.; Prono, G.; Racca, C.; Raia, G.; van Randwijk, J.; Real, D.; Reed, C.; Réthoré, F.; Rewiersma, P.; Riccobene, G.; Richardt, C.; Richter, R.; Ricol, J. S.; Rigaud, V.; Roca, V.; Roensch, K.; Rolin, J.-F.; Rostovtsev, A.; Rottura, A.; Roux, J.; Rujoiu, M.; Ruppi, M.; Russo, G. V.; Salesa, F.; Salomon, K.; Sapienza, P.; Schmitt, F.; Schöck, F.; Schuller, J.-P.; Schüssler, F.; Sciliberto, D.; Shanidze, R.; Shirokov, E.; Simeone, F.; Sottoriva, A.; Spies, A.; Spona, T.; Spurio, M.; Steijger, J. J. M.; Stolarczyk, Th.; Streeb, K.; Sulak, L.; Taiuti, M.; Tamburini, C.; Tao, C.; Tasca, L.; Terreni, G.; Tezier, D.; Toscano, S.; Urbano, F.; Valdy, P.; Vallage, B.; van Elewyck, V.; Vannoni, G.; Vecchi, M.; Venekamp, G.; Verlaat, B.; Vernin, P.; Virique, E.; de Vries, G.; van Wijk, R.; Wijnker, G.; Wobbe, G.; de Wolf, E.; Yakovenko, Y.; Yepes, H.; Zaborov, D.; Zaccone, H.; Zornoza, J. D.; Zúñiga, J.

    2011-11-01

    The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design, the construction and the installation of the telescope in the deep sea, offshore from Toulon in France. An illustration of the detector performance is given.

  10. Parameterized Telescoping Proves Algebraic Independence of Sums

    CERN Document Server

    Schneider, Carsten

    2008-01-01

    Usually creative telescoping is used to derive recurrences for sums. In this article we show that the non-existence of a creative telescoping solution, and more generally, of a parameterized telescoping solution, proves algebraic independence of certain types of sums. Combining this fact with summation-theory shows transcendence of whole classes of sums. Moreover, this result throws new light on the question why, e.g., Zeilberger's algorithm fails to find a recurrence with minimal order.

  11. The SAFT-UT (synthetic aperture focusing technique for ultrasonic testing) real-time inspection system: Operational principles and implementation

    Energy Technology Data Exchange (ETDEWEB)

    Hall, T. E.; Reid, L. D.; Doctor, S. R.

    1988-06-01

    This document provides a technical description of the real-time imaging system developed for rapid flaw detection and characterization utilizing the synthetic aperture focusing technique for ultrasonic testing (SAFT-UT). The complete fieldable system has been designed to perform inservice inspection of light-water reactor components. Software was written on a DEC LSI 11/23 computer system to control data collection. The unprocessed data is transferred to a VAX 11/730 host computer to perform data processing and image display tasks. A parallel architecture peripheral to the host computer, referred to as the Real-Time SAFT Processor, rapidly performs the SAFT processing function. From the host's point of view, this device operates on the SAFT data in such a way that one may consider it to be a specialized or SAFT array processor. A guide to SAFT-UT theory and conventions is included, along with a detailed description of the operation of the software, how to install the software, and a detailed hardware description.

  12. Development of Wall Thinning Distinction Method using the Multi-inspecting UT Data of Carbon Steel Piping

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Kyeong Mo; Yun, Hun; Lee, Chan Kyoo [KEPCO E and C, Yongin (Korea, Republic of)

    2012-05-15

    To manage the wall thinning of carbon steel piping in nuclear power plants, the utility of Korea has performed thickness inspection for some quantity of pipe components during refueling outages and determined whether repair or replacement after evaluating UT (Ultrasonic Test) data. When the existing UT data evaluation methods, such as Band, Blanket, PTP (Point to Point) Methods, are applied to a certain pipe component, unnecessary re-inspecting situations may be generated even though the component does not thinned. In those cases, economical loss caused by repeated inspection and problems of maintaining the pipe integrity followed by decreasing of newly inspected components may be generated. EPRI (Electric Power Research Institute) in USA has suggested several statistical methods, TPM (Total Point Method), LSS (Least Square Slope) Method, etc. to distinguish whether multiple inspecting components have thinned or not. This paper presents the analysis results for multiple inspecting components over three times based on both NAM (Near Area of Minimum) Method developed by KEPCO-E and C and the other methods suggested by EPRI.

  13. The Radio-to-X-Ray Spectrum of GRB 970508 on 1997 May 21.0 UT

    Science.gov (United States)

    Galama, T. J.; Wijers, R. A. M. J.; Bremer, M.; Groot, P. J.; Strom, R. G.; Kouveliotou. C.; vanParadijs, J.

    1998-01-01

    We have reconstructed the spectrum of the afterglow of GRB 970508 on 1997 May 21.0 UT (12.1 days after the gamma-ray burst burst) on the basis of observations spanning, the X-ray-to-radio range. The low-frequency power-law index of the spectrum, alpha = 0.44 +/- 0.07 (F, proportional to nu(sup alpha)) is in agreement with the expected value alpha = 1/3 for optically thin synchrotron radiation. The 1.4 emission is self-absorbed. We infer constraints on the break frequencies nu(sub c) and nu(sub m) on 1997 May 21.0 UT from a spectral transition from F, approximately nu(sup -0.6) to F, approximately nu(sup -1.1) in the optical passband around 1.4 days. A model of an adiabatically expanding blast wave emitting synchrotrons radiation, in which a significant fraction of the electrons cool rapidly, provides a successful and consistent description of the afterglow observations over nine decades in frequency, ranging in time from trigger until several months later.

  14. Resolution studies with the DATURA beam telescope

    CERN Document Server

    Jansen, Hendrik

    2016-01-01

    We present resolution studies carried out with the DATURA beam telescope, which belongs to the family of EUDET-type beam telescopes. The EUDET-type beam telescopes make use of CMOS MIMOSA 26 pixel detectors for particle tracking allowing for precise characterisation of particle sensing devices. A profound understanding of the performance of the beam telescope as a whole is obtained by a detailed characterisation of the sensors themselves. We extract the differential intrinsic resolution as measured in a MIMOSA 26 sensor using an iterative pull method and show various clustersize dependent quantities as the residual distribution, the intra-pixel residual width distribution and the intra-pixel frequency distribution.

  15. Slipping reconnection in a solar flare observed in high resolution with the GREGOR solar telescope

    CERN Document Server

    Sobotka, M; Denker, C; Balthasar, H; Jurčák, J; Liu, W; Berkefeld, T; Vera, M Collados; Feller, A; Hofmann, A; Kneer, F; Kuckein, C; Lagg, A; Louis, R E; von der Lühe, O; Nicklas, H; Schlichenmaier, R; Schmidt, D; Schmidt, W; Sigwarth, M; Solanki, S K; Soltau, D; Staude, J; Strassmeier, K G; Volkmer, R; Waldmann, T

    2016-01-01

    A small flare ribbon above a sunspot umbra in active region 12205 was observed on November 7, 2014, at 12:00 UT in the blue imaging channel of the 1.5 m GREGOR telescope, using a 1 A Ca II H interference filter. Context observations from the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO), the Solar Optical Telescope (SOT) onboard Hinode, and the Interface Region Imaging Spectrograph (IRIS) show that this ribbon is part of a larger one that extends through the neighboring positive polarities and also participates in several other flares within the active region. We reconstructed a time series of 140 seconds of Ca II H images by means of the multiframe blind deconvolution method, which resulted in spatial and temporal resolutions of 0.1 arcsec and 1 s. Light curves and horizontal velocities of small-scale bright knots in the observed flare ribbon were measured. Some knots are stationary, but three move along the ribbon with speeds of 7-11 km/s. Two of them move in the opposite d...

  16. Aerosols in the tropical and subtropical UT/LS: in-situ measurements of submicron particle abundance and volatility

    Directory of Open Access Journals (Sweden)

    S. Borrmann

    2010-06-01

    Full Text Available Processes occurring in the tropical upper troposphere (UT, the Tropical Transition Layer (TTL, and the lower stratosphere (LS are of importance for the global climate, for stratospheric dynamics and air chemistry, and for their influence on the global distribution of water vapour, trace gases and aerosols. In this contribution we present aerosol and trace gas (in-situ measurements from the tropical UT/LS over Southern Brazil, Northern Australia, and West Africa. The instruments were operated on board of the Russian high altitude research aircraft M-55 "Geophysica" and the DLR Falcon-20 during the campaigns TROCCINOX (Araçatuba, Brazil, February 2005, SCOUT-O3 (Darwin, Australia, December 2005, and SCOUT-AMMA (Ouagadougou, Burkina Faso, August 2006. The data cover submicron particle number densities and volatility from the COndensation PArticle counting System (COPAS, as well as relevant trace gases like N2O, ozone, and CO. We use these trace gas measurements to place the aerosol data into a broader atmospheric context. Also a juxtaposition of the submicron particle data with previous measurements over Costa Rica and other tropical locations between 1999 and 2007 (NASA DC-8 and NASA WB-57F is provided. The submicron particle number densities, as a function of altitude, were found to be remarkably constant in the tropical UT/LS altitude band for the two decades after 1987. Thus, a parameterisation suitable for models can be extracted from these measurements. Compared to the average levels in the period between 1987 and 2007 a slight increase of particle abundances was found for 2005/2006 at altitudes with potential temperatures, Θ, above 430 K. The origins of this increase are unknown except for increases measured during SCOUT-AMMA. Here the eruption of the Soufrière Hills volcano in the Caribbean caused elevated particle mixing ratios. The vertical profiles from Northern hemispheric mid-latitudes between 1999 and 2006 also are

  17. Aerosols in the tropical and subtropical UT/LS: in-situ measurements of submicron particle abundance and volatility

    Science.gov (United States)

    Borrmann, S.; Kunkel, D.; Weigel, R.; Minikin, A.; Deshler, T.; Wilson, J. C.; Curtius, J.; Volk, C. M.; Homan, C. D.; Ulanovsky, A.; Ravegnani, F.; Viciani, S.; Shur, G. N.; Belyaev, G. V.; Law, K. S.; Cairo, F.

    2010-06-01

    Processes occurring in the tropical upper troposphere (UT), the Tropical Transition Layer (TTL), and the lower stratosphere (LS) are of importance for the global climate, for stratospheric dynamics and air chemistry, and for their influence on the global distribution of water vapour, trace gases and aerosols. In this contribution we present aerosol and trace gas (in-situ) measurements from the tropical UT/LS over Southern Brazil, Northern Australia, and West Africa. The instruments were operated on board of the Russian high altitude research aircraft M-55 "Geophysica" and the DLR Falcon-20 during the campaigns TROCCINOX (Araçatuba, Brazil, February 2005), SCOUT-O3 (Darwin, Australia, December 2005), and SCOUT-AMMA (Ouagadougou, Burkina Faso, August 2006). The data cover submicron particle number densities and volatility from the COndensation PArticle counting System (COPAS), as well as relevant trace gases like N2O, ozone, and CO. We use these trace gas measurements to place the aerosol data into a broader atmospheric context. Also a juxtaposition of the submicron particle data with previous measurements over Costa Rica and other tropical locations between 1999 and 2007 (NASA DC-8 and NASA WB-57F) is provided. The submicron particle number densities, as a function of altitude, were found to be remarkably constant in the tropical UT/LS altitude band for the two decades after 1987. Thus, a parameterisation suitable for models can be extracted from these measurements. Compared to the average levels in the period between 1987 and 2007 a slight increase of particle abundances was found for 2005/2006 at altitudes with potential temperatures, Θ, above 430 K. The origins of this increase are unknown except for increases measured during SCOUT-AMMA. Here the eruption of the Soufrière Hills volcano in the Caribbean caused elevated particle mixing ratios. The vertical profiles from Northern hemispheric mid-latitudes between 1999 and 2006 also are compact enough to derive a

  18. Planar Solid-Oxide Fuel Cell System Demonstration at UT SimCenter

    Science.gov (United States)

    2015-12-09

    Cengel [117] and Chase [118] summarized the empirical expression of Cpj(T) as follows, CPj (T) = Aj + BfT + CjT 2 + DjT3 (36) 33 I Page Project final...auxiliary power units. International Journal of Hydrogen Energy. 2008, 33, 1067-1075 [117] Y. A. Cengel . Introduction to Thermodynamics and Heat

  19. Platelet-derived growth factor receptors form complexes with neuropilin-1 during megakaryocytic differentiation of thrombopoietin-dependent UT-7/TPO cells.

    Science.gov (United States)

    Ohsaka, Akimichi; Hirota-Komatsu, Satoko; Araki, Marito; Komatsu, Norio

    2015-04-10

    Neuropilin-1 (NRP-1) is involved in angiogenesis, but the role of NRP-1 in megakaryocytopoiesis is not yet fully understood. In this study, we investigated whether thrombopoietin (TPO) regulates the expression of platelet-derived growth factor (PDGF) and its receptors (PDGFRs) on TPO-dependent UT-7/TPO cells and whether PDGFRs and NRP-1 on UT-7/TPO cells form complexes during megakaryocytic differentiation. When UT-7/TPO cells were starved of TPO for 24 h and then stimulated with 5 ng/ml TPO, the expression of PDGF-B, PDGFRα, and PDGFRβ were significantly up-regulated after the addition of TPO. TPO also induced tyrosine phosphorylation of PDGFRα but not PDGFRβ, and promoted the formation of PDGFRαβ heterodimer complexes. Furthermore, megakaryocytic differentiation of UT-7/TPO cells on treatment with phorbol myristate acetate (PMA) was accompanied by a marked up-regulation of PDGFRβ and NRP-1 protein expression, complex formation between PDGFRs and NRP-1, PDGFRαβ heterodimer complexes, and an increase in PDGF-BB-binding activity. Immunocytochemistry confirmed complex formation between PDGFRs and NRP-1 and PDGFRαβ heterodimer complexes in PMA-differentiated UT-7/TPO cells. Our observations suggest that NRP-1 is involved in megakaryocytopoiesis through complex formation with PDGFRs, and that NRP-1-PDGFR-complexes may contribute to effective cellular functions mediated by TPO and PDGF in megakaryocytic cells.

  20. COSMOS Hubble Space Telescope Observations

    CERN Document Server

    Scoville, N Z; Blain, A W; Calzetti, D; Comastri, A; Capak, P; Carilli, C; Carlstrom, J E; Carollo, C M; Colbert, J; Daddi, E; Ellis, Richard S; Elvis, M; Ewald, S P; Fall, M; Franceschini, A; Giavalisco, M; Green, W; Griffiths, R E; Guzzo, L; Hasinger, G; Impey, C; Kneib, J P; Koda, J; Koekemoer, A; Lefèvre, O; Lilly, S; Liu, C T; McCracken, H J; Massey, R; Mellier, Y; Miyazaki, S; Mobasher, B; Mould, J; Norman, C; Réfrégier, A; Renzini, A; Rhodes, J; Rich, M; Sanders, D B; Schiminovich, D; Schinnerer, E; Scodeggio, M; Sheth, K; Shopbell, P L; Taniguchi, Y; Tyson, N; Urry, C M; Van Waerbeke, L; Vettolani, P; White, S D M; Yan, L

    2006-01-01

    The Cosmic Evolution Survey (COSMOS) was initiated with an extensive allocation (590 orbits in Cycles 12-13) using the Hubble Space Telescope (HST) for high resolution imaging. Here we review the characteristics of the HST imaging with the Advanced Camera for Surveys (ACS) and parallel observations with NICMOS and WFPC2. A square field (1.8$\\sq$\\deg) has been imaged with single-orbit ACS I-F814W exposures with 50% completeness for sources 0.5\\arcsec in diameter at I$_{AB} $ = 26.0 mag. The ACS imaging is a key part of the COSMOS survey, providing very high sensitivity and high resolution (0.09\\arcsec FWHM, 0.05\\arcsec pixels) imaging and detecting a million objects. These images yield resolved morphologies for several hundred thousand galaxies. The small HST PSF also provides greatly enhanced sensitivity for weak lensing investigations of the dark matter distribution.

  1. Adaptive Optics for Large Telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Olivier, S

    2008-06-27

    The use of adaptive optics was originally conceived by astronomers seeking to correct the blurring of images made with large telescopes due to the effects of atmospheric turbulence. The basic idea is to use a device, a wave front corrector, to adjust the phase of light passing through an optical system, based on some measurement of the spatial variation of the phase transverse to the light propagation direction, using a wave front sensor. Although the original concept was intended for application to astronomical imaging, the technique can be more generally applied. For instance, adaptive optics systems have been used for several decades to correct for aberrations in high-power laser systems. At Lawrence Livermore National Laboratory (LLNL), the world's largest laser system, the National Ignition Facility, uses adaptive optics to correct for aberrations in each of the 192 beams, all of which must be precisely focused on a millimeter scale target in order to perform nuclear physics experiments.

  2. The ANTARES underwater neutrino telescope

    CERN Document Server

    Montaruli, Teresa

    2015-01-01

    ANTARES is the first undersea neutrino telescope. It is in its complete configuration since May 2008 at about 2.5 km below the sea surface close to Marseille. Data from 12 lines are being analyzed and are producing first results. Here we discuss first analysis results for 5 lines and 10 lines, and we also comment on the performance of the full detector. We show that the detector has capabilities for discriminating upgoing neutrino events from the much larger amount of downgoing atmospheric muons and that data and simulation are in good agreement. We then discuss the physics reach of the detector for what concerns point-like source and dark matter searches.

  3. Can Radio Telescopes Find Axions?

    Science.gov (United States)

    Kohler, Susanna

    2017-08-01

    axions. Now scientists Katharine Kelley and Peter Quinn at ICRAR, University of Western Australia, have explored how we might use next-generation radio telescopes to search for photons that were created by axions interacting with the magnetic fields of our galaxy.Hope for Next-Gen TelescopesPotential axion coupling strengths vs. mass (click for a closer look). The axion mass is thought to lie between a eV and a meV; two theoretical models are shown with dashed lines. The plot shows the sensitivity of the upcoming SKA and its precursors, ASKAP and MEERKAT. [KelleyQuinn 2017]By using a simple galactic halo model and reasonable assumptions for the central galactic magnetic field even taking into account the time dependence of the field Kelley and Quinn estimate the radio-frequency power density that we would observe at Earth from axions being converted to photons within the Milky Ways magnetic field.The authors then compare this signature to the detection capabilities of upcoming radio telescope arrays. They show that the upcoming Square Kilometer Array and its precursors should have the capability to detect signs of axions across large parts of parameter space.Kelley and Quinn conclude that theres good cause for optimism about future radio telescopes ability to detect axions. And if we did succeed in making a detection, it would be a triumph for both particle physics and astrophysics, finally providing an explanation for the universes dark matter.CitationKatharine Kelley and P. J. Quinn 2017 ApJL 845 L4. doi:10.3847/2041-8213/aa808d

  4. Recent Results from Telescope Array

    CERN Document Server

    Fukushima, M

    2015-01-01

    The Telescope Array (TA) is an experiment to observe Ultra-High Energy Cosmic Rays (UHECRs). TA's recent results, the energy spectrum and anisotropy based on the 6-year surface array data, and the primary composition obtained from the shower maximum Xmax are reported. The spectrum demonstrates a clear dip and cutoff. The shape of the spectrum is well described by the energy loss of extra-galactic protons interacting with the cosmic microwave background (CMB). Above the cutoff, a medium-scale (20 degrees radius) flux enhancement was observed near the Ursa-Major. A chance probability of creating this hotspot from the isotropic flux is 4.0 sigma. The measured Xmax is consistent with the primary being proton or light nuclei for energies 10^18.2 eV - 10^19.2 eV.

  5. Cosmography with the Einstein Telescope

    Energy Technology Data Exchange (ETDEWEB)

    Sathyaprakash, B S [School of Physics and Astronomy, Cardiff University, Cardiff, CF24 3AA (United Kingdom); Schutz, B F [Max Planck Institute for Gravitational Physics, The Albert Einstein Institute, Am Muehlenberg 1, Golm, D-14476 (Germany); Van Den Broeck, C, E-mail: B.Sathyaprakash@astro.cf.ac.u, E-mail: B.F.Schutz@aei.mpg.d, E-mail: vdbroeck@nikhef.n [Nikhef - National Institute for Subatomic Physics, Science Park 105, 1098 XG Amsterdam (Netherlands)

    2010-11-07

    The Einstein Telescope, a third-generation gravitational-wave detector under a design study, could detect millions of binary neutron star inspirals each year. A small fraction of these events might be observed as gamma-ray bursts, helping to measure both the luminosity distance D{sub L} to and redshift z of the source. By fitting these measured values of D{sub L} and z to a cosmological model, it would be possible to infer the dark energy equation of state to within 1.5% without the need to correct for errors in D{sub L} caused by weak lensing. This compares favourably with 0.3-10% accuracy that can be achieved with the Laser Interferometer Space Antenna (where weak lensing will need to be dealt with) as well as with dedicated dark energy missions that have been proposed, where 3.5-11% uncertainty is expected.

  6. NESTOR Deep Sea Neutrino Telescope

    Science.gov (United States)

    NESTOR Collaboration; Aggouras, G.; Anassontzis, E. G.; Ball, A. E.; Bourlis, G.; Chinowsky, W.; Fahrun, E.; Grammatikakis, G.; Green, C.; Grieder, P.; Katrivanos, P.; Koske, P.; Leisos, A.; Markopoulos, E.; Minkowsky, P.; Nygren, D.; Papageorgiou, K.; Przybylski, G.; Resvanis, L. K.; Siotis, I.; Sopher, J.; Staveris-Polikalas, A.; Tsagli, V.; Tsirigotis, A.; Tzamarias, S.; Zhukov, V. A.

    2006-01-01

    One module of NESTOR, the Mediterranean deep-sea neutrino telescope, was deployed at a depth of 4000m, 14km off the Sapienza Island, off the South West coast of Greece. The deployment site provides excellent environmental characteristics. The deployed NESTOR module is constructed as a hexagonal star like latticed titanium star with 12 Optical Modules and an one-meter diameter titanium sphere which houses the electronics. Power and data were transferred through a 30km electro-optical cable to the shore laboratory. In this report we describe briefly the detector and the detector electronics and discuss the first physics data acquired and give the zenith angular distribution of the reconstructed muons.

  7. Diffractive X-Ray Telescopes

    Science.gov (United States)

    Skinner, Gerald K.

    2010-01-01

    Diffractive X-ray telescopes, using zone plates, phase Fresnel lenses, or related optical elements have the potential to provide astronomers with true imaging capability with resolution many orders of magnitude better than available in any other waveband. Lenses that would be relatively easy to fabricate could have an angular resolution of the order of micro-arc-seconds or even better, that would allow, for example, imaging of the distorted spacetime in the immediate vicinity of the super-massive black holes in the center of active galaxies. What then is precluding their immediate adoption? Extremely long focal lengths, very limited bandwidth, and difficulty stabilizing the image are the main problems. The history, and status of the development of such lenses is reviewed here and the prospects for managing the challenges that they present are discussed.

  8. Diffractive X-ray Telescopes

    CERN Document Server

    Skinner, Gerald K

    2010-01-01

    Diffractive X-ray telescopes using zone plates, phase Fresnel lenses, or related optical elements have the potential to provide astronomers with true imaging capability with resolution several orders of magnitude better than available in any other waveband. Lenses that would be relatively easy to fabricate could have an angular resolution of the order of micro-arc-seconds or even better, that would allow, for example, imaging of the distorted space- time in the immediate vicinity of the super-massive black holes in the center of active galaxies What then is precluding their immediate adoption? Extremely long focal lengths, very limited bandwidth, and difficulty stabilizing the image are the main problems. The history, and status of the development of such lenses is reviewed here and the prospects for managing the challenges that they present are discussed.

  9. SEMICONDUCTOR INTEGRATED CIRCUITS: A novel fully differential telescopic operational transconductance amplifier

    Science.gov (United States)

    Tianwang, Li; Bo, Ye; Jinguang, Jiang

    2009-08-01

    A novel fully differential telescopic operational transconductance amplifier (OTA) is proposed. An additional PMOS differential pair is introduced to improve the unit-gain bandwidth of the telescopic amplifier. At the same time, the slew rate is enhanced by the auxiliary slew rate boost circuits. The proposed OTA is designed in a 0.18μm CMOS process. Simulation results show that there is a 49% improvement in the unit-gain bandwidth compared to that of a conventional OTA; moreover, the DC gain and the slew rate are also enhanced.

  10. A Study of the Fitting Accuracy of the Active Reflector for a Large Spherical Radio Telescope

    Institute of Scientific and Technical Information of China (English)

    Xiao-Qiang Tang; Jin-Song Wang; Qi-Ming Wang

    2003-01-01

    We propose a spatial three-degree-of-freedom (DOF) parallel mechanism combining two degrees of rotations and one degree of translation to support the active reflector units of a large spherical radio telescope. The kinematics, workspace and accuracy of the mechanism are analyzed. One-dimensional and two-dimensional fitting errors to the working region of active reflector are investigated. Dimensional parameters of the mechanism and active reflector unit are examined with respect to the requirement of fitting accuracy. The result of accuracy analysis shows the effectiveness and feasibility of the proposed mechanism, and gives a design rule to guarantee the highest working frequency required by large radio telescope.

  11. IR spectrometer project for the BTA telescope

    Science.gov (United States)

    Afanasiev, V. L.; Emelianov, E. V.; Murzin, V. A.; Vdovin, V. F.

    2013-07-01

    We introduce a project of new cooled infrared spectrometer-photometer for 6-m telescope BTA (Special Astrophysical Observatory of Russian Science Academy). The device would extend the wavelength range accessible for observations on the 6-m BTA telescope toward near infrared (0.8-2.5 um).

  12. A Mechanical Analogue of the Refracting Telescope

    Science.gov (United States)

    Vannoni, Maurizio; Molesini, Giuseppe; Sordini, Andrea; Straulino, Samuele

    2011-01-01

    The recent celebration of the discoveries made by Galileo four centuries ago has attracted new attention to the refracting telescope and to its use as an instrument for the observation of the night sky. This has offered the opportunity for addressing in the classroom the basic principles explaining the operation of the telescope. When doing so, a…

  13. Solar Magnetometry with the dutch open telescope

    NARCIS (Netherlands)

    Rutten, R.J.; Hammerschlag, R.H.; Sütterlin, P.; Bettonvil, F.C.M.; Zalm, E.B.J. van der

    2001-01-01

    The Dutch Open Telescope (DOT) has become op- erational at the Roque de los Muchachos Observa- tory on La Palma. The rst image sequences taken with this innovative telescope demonstrate its capa- bility for tomographic high-resolution imaging of the magnetic topology of the solar atmosphere up to th

  14. ANTARES : The first undersea neutrino telescope

    NARCIS (Netherlands)

    Ageron, M.; Aguilar, J. A.; Al Samarai, I.; Albert, A.; Ameli, F.; Andre, M.; Anghinolfi, M.; Anton, G.; Anvar, S.; Ardid, M.; Arnaud, K.; Aslanides, E.; Jesus, A. C. Assis; Astraatmadja, T.; Aubert, J. -J.; Auer, R.; Barbarito, E.; Baret, B.; Basa, S.; Bazzotti, M.; Becherini, Y.; Beltramelli, J.; Bersani, A.; Bertin, V.; Beurthey, S.; Biagi, S.; Bigongiari, C.; Billault, M.; Blaes, R.; Bogazzi, C.; de Botton, N.; Bou-Cabo, M.; Boudahef, B.; Bouwhuis, M. C.; Brown, A. M.; Brunner, J.; Busto, J.; Caillat, L.; Calzas, A.; Camarena, F.; Capone, A.; Caponetto, L.; Carloganu, C.; Carminati, G.; Carmona, E.; Carr, J.; Carton, P. H.; Cassano, B.; Castorina, E.; Cecchini, S.; Ceres, A.; Chaleil, Th; Charvis, Ph; Chauchot, P.; Chiarusi, T.; Circella, M.; Compere, C.; Coniglione, R.; Coppolani, X.; Cosquer, A.; Costantini, H.; Cottini, N.; Coyle, P.; Cuneo, S.; Curtil, C.; D'Amato, C.; Damy, G.; van Dantzig, R.; De Bonis, G.; Decock, G.; Decowski, M. P.; Dekeyser, I.; Delagnes, E.; Desages-Ardellier, F.; Deschamps, A.; Destelle, J. -J.; Di Maria, F.; Dinkespiler, B.; Distefano, C.; Dominique, J. -L.; Donzaud, C.; Dornic, D.; Dorosti, Q.; Drogou, J. -F.; Drouhin, D.; Druillole, F.; Durand, D.; Durand, R.; Eberl, T.; Emanuele, U.; Engelen, J. J.; Ernenwein, J. -P.; Escoffier, S.; Falchini, E.; Favard, S.; Fehr, F.; Feinstein, F.; Ferri, M.; Ferry, S.; Fiorello, C.; Flaminio, V.; Folger, F.; Fritsch, U.; Fuda, J. -L.; Galata, S.; Galeotti, S.; Gay, P.; Gensolen, F.; Giacomelli, G.; Gojak, C.; Gomez-Gonzalez, J. P.; Goret, Ph.; Graf, K.; Guillard, G.; Halladjian, G.; Hallewell, G.; van Haren, H.; Hartmann, B.; Heijboer, A. J.; Heine, E.; Hello, Y.; Henry, S.; Hernandez-Rey, J. J.; Herold, B.; Hoessl, J.; Hogenbirk, J.; Hsu, C. C.; Hubbard, J. R.; Jaquet, M.; Jaspers, M.; de Jong, M.; Jourde, D.; Kadler, M.; Kalantar-Nayestanaki, N.; Kalekin, O.; Kappes, A.; Karg, T.; Karkar, S.; Karolak, M.; Katz, U.; Keller, P.; Kestener, P.; Kok, E.; Kok, H.; Kooijman, P.; Kopper, C.; Kouchner, A.; Kretschmer, W.; Kruijer, A.; Kuch, S.; Kulikovskiy, V.; Lachartre, D.; Lafoux, H.; Lagier, P.; Lahmann, R.; Lahonde-Hamdoun, C.; Lamare, P.; Lambard, G.; Languillat, J-C; Larosa, G.; Lavalle, J.; Le Guen, Y.; Le Provost, H.; LeVanSuu, A.; Lefevre, D.; Legou, T.; Lelaizant, G.; Leveque, C.; Lim, G.; Lo Presti, D.; Loehner, H.; Loucatos, S.; Louis, F.; Lucarelli, F.; Lyashuk, V.; Magnier, P.; Mangano, S.; Marcel, A.; Marcelin, M.; Margiotta, A.; Martinez-Mora, J. A.; Masullo, R.; Mazeas, F.; Mazure, A.; Meli, A.; Melissas, M.; Migneco, E.; Mongelli, M.; Montaruli, T.; Morganti, M.; Moscoso, L.; Motz, H.; Musumeci, M.; Naumann, C.; Naumann-Godo, M.; Neff, M.; Niess, V.; Nooren, G. J. L.; Oberski, J. E. J.; Olivetto, C.; Palanque-Delabrouille, N.; Patioselitis, D.; Papaleo, R.; Pavalas, G. E.; Payet, K.; Payre, P.; Peek, H.; Petrovic, J.; Piattelli, P.; Picot-Clemente, N.; Picq, C.; Piret, Y.; Poinsignon, J.; Popa, V.; Pradier, T.; Presani, E.; Prono, G.; Racca, C.; Raia, G.; van Randwijk, J.; Real, D.; Reed, C.; Rethore, F.; Rewiersma, P.; Riccobene, G.; Richardt, C.; Richter, R.; Ricol, J. S.; Rigaud, V.; Roca, V.; Roensch, K.; Rolin, J. -F.; Rostovtsev, A.; Rottura, A.; Roux, J.; Rujoiu, M.; Ruppi, M.; Russo, G. V.; Salesa, F.; Salomon, K.; Sapienza, P.; Schmitt, F.; Schoeck, F.; Schuller, J. -P.; Schuessler, F.; Sciliberto, D.; Shanidze, R.; Shirokov, E.; Simeone, F.; Sottoriva, A.; Spies, A.; Spona, T.; Spurio, M.; Steijger, J. J. M.; Stolarczyk, Th; Streeb, K.; Sulak, L.; Taiuti, M.; Tamburini, C.; Tao, C.; Tasca, L.; Terreni, G.; Tezier, D.; Toscano, S.; Urbano, F.; Valdy, P.; Vallage, B.; Van Elewyck, V.; Vannoni, G.; Vecchi, M.; Venekamp, G.; Verlaat, B.; Vernin, P.; Virique, E.; de Vries, G.; Wijnker, G.; Wobbe, G.; de Wolf, E.; Yakovenko, Y.; Yepes, H.; Zaborov, D.; Zaccone, H.; Zornoza, J. D.; Zuniga, J.; van Wijk, R.

    2011-01-01

    The ANTARES Neutrino Telescope was completed in May 2008 and is the first operational Neutrino Telescope in the Mediterranean Sea. The main purpose of the detector is to perform neutrino astronomy and the apparatus also offers facilities for marine and Earth sciences. This paper describes the design

  15. Lijiang 2.4m Optical Telescope

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The 2.4m optical telescope of Yunnan Observatory was installed at Lijiang Observatory in the northwest of the Yunnan Province in 2007, which became operational since May 2008. At present, it is the largest general-use optical telescope in East Asia.

  16. Hard x-ray telescope mission

    DEFF Research Database (Denmark)

    Gorenstein, P.; Worrall, D.; Joensen, K.D.

    1996-01-01

    The Hard X-Ray Telescope was selected for study as a possible new intermediate size mission for the early 21st century. Its principal attributes are: (1) multiwavelength observing with a system of focussing telescopes that collectively observe from the UV to over 1 MeV, (2) much higher sensitivity...

  17. IR Spectrometer Project for the BTA Telescope

    OpenAIRE

    Afanasiev, V. L.; Emelianov, E. V.; Murzin, V. A.; Vdovin, V. F.

    2013-01-01

    We introduce a project of new cooled infrared spectrometer-photometer for 6-m telescope BTA (Special Astrophysical Observatory of Russian Science Academy). The device would extend the wavelength range accessible for observations on the 6-m BTA telescope toward near infrared (0.8-2.5 um).

  18. 1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.

    Science.gov (United States)

    Liu, Y; Esteva-Font, C; Yao, C; Phuan, P W; Verkman, A S; Anderson, M O

    2013-06-01

    The kidney urea transport protein UT-B is an attractive target for the development of small-molecule inhibitors with a novel diuretic ('urearetic') action. Previously, two compounds in the triazolothienopyrimidine scaffold (1a and 1c) were reported as UT-B inhibitors. Compound 1c incorporates a 1,1-difluoroethyl group, which affords improved microsomal stability when compared to the corresponding ethyl-substituted compound 1a. Here, a small focused library (4a-4f) was developed around lead inhibitor 1c to investigate the requirement of an amidine-linked thiophene in the inhibitor scaffold. Two compounds (4a and 4b) with nanomolar inhibitory potency (IC50≈40 nM) were synthesized. Computational docking of lead structure 1c and 4a-4f into a homology model of the UT-B cytoplasmic surface suggested binding with the core heterocycle buried deep into the hydrophobic pore region of the protein.

  19. DAG telescope site studies and infrastructure for possible international co-operations

    Science.gov (United States)

    Yerli, Sinan K.; Yeşilyaprak, Cahit; Keskin, Onur; Alis, Sinan

    2016-07-01

    The selected site for the 4 m DAG (Eastern Anatolian Observatory in Turkish) telescope is at "Karakaya Ridge", at 3170 m altitude (3150 m after summit management). The telescope's optical design is performed by the DAG technical team to allow infrared observation at high angular resolution, with its adaptive optics system to be built in Turkey. In this paper; a brief introduction about DAG telescope design; planned instrumentation; the meteorological data collected from 2008, clear night counts, short-term DIMM observations; current infrastructure to hold auxiliary telescopes; auxiliary buildings to assist operations; the observatory design; and coating unit plans will be presented along with possible collaboration possibilities in terms of instrumentation and science programs.

  20. LUNASKA simultaneous neutrino searches with multiple telescopes

    CERN Document Server

    Bray, J D; James, C W; Roberts, P; Brown, A; Phillips, C J; Protheroe, R J; Reynolds, J E; McFadden, R A; Aartsen, M

    2011-01-01

    The most sensitive method for detecting neutrinos at the very highest energies is the lunar Cherenkov technique, which employs the Moon as a target volume, using conventional radio telescopes to monitor it for nanosecond-scale pulses of Cherenkov radiation from particle cascades in its regolith. Multiple-antenna radio telescopes are difficult to effectively combine into a single detector for this purpose, while single antennas are more susceptible to false events from radio interference, which must be reliably excluded for a credible detection to be made. We describe our progress in excluding such interference in our observations with the single-antenna Parkes radio telescope, and our most recent experiment (taking place the week before the ICRC) using it in conjunction with the Australia Telescope Compact Array, exploiting the advantages of both types of telescope.

  1. Calibration of the Cherenkov Telescope Array

    CERN Document Server

    Gaug, Markus; Berge, David; Reyes, Raquel de los; Doro, Michele; Foerster, Andreas; Maccarone, Maria Concetta; Parsons, Dan; van Eldik, Christopher

    2015-01-01

    The construction of the Cherenkov Telescope Array is expected to start soon. We will present the baseline methods and their extensions currently foreseen to calibrate the observatory. These are bound to achieve the strong requirements on allowed systematic uncertainties for the reconstructed gamma-ray energy and flux scales, as well as on the pointing resolution, and on the overall duty cycle of the observatory. Onsite calibration activities are designed to include a robust and efficient calibration of the telescope cameras, and various methods and instruments to achieve calibration of the overall optical throughput of each telescope, leading to both inter-telescope calibration and an absolute calibration of the entire observatory. One important aspect of the onsite calibration is a correct understanding of the atmosphere above the telescopes, which constitutes the calorimeter of this detection technique. It is planned to be constantly monitored with state-of-the-art instruments to obtain a full molecular and...

  2. A telescope with augmented reality functions

    Science.gov (United States)

    Hou, Qichao; Cheng, Dewen; Wang, Qiwei; Wang, Yongtian

    2016-10-01

    This study introduces a telescope with virtual reality (VR) and augmented reality (AR) functions. In this telescope, information on the micro-display screen is integrated to the reticule of telescope through a beam splitter and is then received by the observer. The design and analysis of telescope optical system with AR and VR ability is accomplished and the opto-mechanical structure is designed. Finally, a proof-of-concept prototype is fabricated and demonstrated. The telescope has an exit pupil diameter of 6 mm at an eye relief of 19 mm, 6° field of view, 5 to 8 times visual magnification , and a 30° field of view of the virtual image.

  3. Optical design of a rotating eyepiece telescope

    Science.gov (United States)

    Siddique, M.; Nasim, F.; Khan, A. N.; Gul, A.

    2016-08-01

    Flexible eyepiece telescope has been designed and verified. The rotating eyepiece of telescope will facilitate viewing of objects in a remote or out of sight target. Eyepiece arm of telescope can be rotated upto 360o keeping objective and reticule unchanged and ensuring zero deviation in reticule inclination. Main application of this scope is off axis viewing of objects. Image inversion has been carried out by using pair of mirrors and length of telescope is controlled by using relay lenses. The optical design, simulation and image analysis has been carried out by using ZEMAX®. Magnification of telescope is between 10∼⃒12 times with FOV of 60. Experiment has been carried out using uncoated Edmund Optics and optical tool box of Micro Series Kit, NEWPORT.

  4. Performance of the SST-1M telescope for the Cherenkov Telescope Array observatory

    CERN Document Server

    Moderski, R; Błocki, J.; Bogacz, L.; Bulik, T.; Cadoux, F.; Christov, A.; Chruślińska, M.; Curyło, M.; della Volpe, D.; Dyrda, M.; Favre, Y.; Frankowski, A.; Grudnik, Ł.; Grudzińska, M.; Heller, M.; Idźkowski, B.; Jamrozy, M.; Janiak, M.; Kasperek, J.; Lalik, K.; Lyard, E.; Mach, E.; Mandat, D.; Marszałek, A.; Michałowski, J.; Montaruli, T.; Neronov, A.; Niemiec, J.; Ostrowski, M.; Paśko, P.; Pech, M.; Porcelli, A.; Prandini, E.; Pueschel, E.; Rajda, P.; Rameez, M.; Rozwadowski, P.; Schioppa, E. jr; Schovanek, P.; Seweryn, K.; Skowron, K.; Sliusar, V.; Sowiński, M.; Stawarz, Ł.; Stodulska, M.; Stodulski, M.; Toscano, S.; Pujadas, I. Troyano; Walter, R.; Wiȩcek, M.; Zagdański, A.; Ziȩtara, K.; Żychowski, P.

    2015-01-01

    The single mirror small-size telescope (SST-1M) is one of the telescope projects being proposed for the Cherenkov Telescope Array observatory by a sub-consortium of Polish and Swiss institutions. The SST-1M prototype structure is currently being constructed at the Institute of Nuclear Physics in Cracow, Poland, while the camera will be assembled at the University of Geneva, Switzerland. This prototype enables measurements of parameters having a decisive influence on the telescope performance. We present results of numerical simulations of the SST-1M performance based on such measurements. The telescope effective area, the expected trigger rates and the optical point spread function are calculated.

  5. Design of the STAR-X Telescope

    Science.gov (United States)

    Saha, Timo T.; Zhang, William W.; McClelland, Ryan S.

    2017-01-01

    Top-level science goals of the Survey and Time-domain Astrophysical Research eXplorer (STAR-X) include: investigations of most violent explosions in the universe, study of growth of black holes across cosmic time and mass scale, and measure how structure formation heats majority of baryons in the universe. To meet these goals, the field-of-view of the telescope should be about 1 square-degree, the angular resolution should be 5 arc-seconds or below across large part of the field-of-view. The on-axis effective area at 1 KeV should be about 2,000 sq cm. Payload cost and launch considerations limit the outer diameter, focal length, and mass to 1.3 meters, 5 meters, and 250 kilograms, respectively. Telescope design is based on a segmented meta-shell approach we have developed at Goddard Space Flight Center for the STAR-X telescope. The telescope shells are divided into 30-degree segments. Individual telescopes and meta-shells are nested inside each other to meet the effective area requirements in 0.5 - 6.0 KeV range. We consider Wolter-Schwarzschild, and Modified-Wolter-Schwarzschild telescope designs as basic building blocks of the nested STAR-X telescope. These designs offer an excellent resolution over a large field of views. Nested telescopes are vulnerable to stray light problems. We have designed a multi-component baffle system to eliminate direct and single-reflection light paths inside the telescopes. Large number of internal and external baffle vane structures are required to prevent stray rays from reaching the focal plane. We have developed a simple ray-trace based tool to determine the dimensions and locations of the baffles. In this paper, we present the results of our trade studies, baffle design studies, and optical performance analyses of the STAR-X telescope.

  6. Beyond the Hubble Space Telescope: Early Development of the Next Generation Space Telescope

    Science.gov (United States)

    Smith, Robert W.; Patrick McCray, W.

    In this paper we investigate the early history of what was at first called the Next Generation Space Telescope, later to be renamed the James Webb Space Telescope. We argue that the initial ideas for such a Next Generation Space Telescope were developed in the context of the planning for a successor to the Hubble Space Telescope. Much the most important group of astronomers and engineers examining such a successor was based at the Space Telescope Science Institute in Baltimore. By the late 1980s, they had fashioned concepts for a successor that would work in optical, ultraviolet and infrared wavelengths, concepts that would later be regarded as politically unrealistic given the costs associated with them. We also explore how the fortunes of the planned Next Generation Space Telescope were intimately linked to that of its "parent," the Hubble Space Telescope.

  7. Monte Carlo Studies of medium-size telescope designs for the Cherenkov Telescope Array

    CERN Document Server

    Wood, M; Dumm, J; Funk, S

    2015-01-01

    We present studies for optimizing the next generation of ground-based imaging atmospheric Cherenkov telescopes (IACTs). Results focus on mid-sized telescopes (MSTs) for CTA, detecting very high energy gamma rays in the energy range from a few hundred GeV to a few tens of TeV. We describe a novel, flexible detector Monte Carlo package, FAST (FAst Simulation for imaging air cherenkov Telescopes), that we use to simulate different array and telescope designs. The simulation is somewhat simplified to allow for efficient exploration over a large telescope design parameter space. We investigate a wide range of telescope performance parameters including optical resolution, camera pixel size, and light collection area. In order to ensure a comparison of the arrays at their maximum sensitivity, we analyze the simulations with the most sensitive techniques used in the field, such as maximum likelihood template reconstruction and boosted decision trees for background rejection. Choosing telescope design parameters repre...

  8. VLTI First Fringes with Two Auxiliary Telescopes at Paranal

    Science.gov (United States)

    2005-03-01

    ESO Video Newsreel 15, released on March 14, 2005. It provides an introduction to the VLT Interferometer (VLTI) and the two Auxiliary Telescopes (ATs) now installed at Paranal. ESO PR Photo 07a/05 shows the impressive ensemble at the summit of Paranal. From left to right, the enclosure of VLT Antu, Kueyen and Melipal, AT1, the VLT Survey Telescope (VST) in the background, AT2 and VLT Yepun. Located at the summit of the 2,600-m high Cerro Paranal in the Atacama Desert (Chile), ESO's Very Large Telescope (VLT) is at the forefront of astronomical technology and is one of the premier facilities in the world for optical and near-infrared observations. The VLT is composed of four 8.2-m Unit Telescope (Antu, Kueyen, Melipal and Yepun). They have been progressively put into service together with a vast suite of the most advanced astronomical instruments and are operated every night in the year. Contrary to other large astronomical telescopes, the VLT was designed from the beginning with the use of interferometry as a major goal. The href="/instruments/vlti">VLT Interferometer (VLTI) combines starlight captured by two 8.2- VLT Unit Telescopes, dramatically increasing the spatial resolution and showing fine details of a large variety of celestial objects. The VLTI is arguably the world's most advanced optical device of this type. It has already demonstrated its powerful capabilities by addressing several key scientific issues, such as determining the size and the shape of a variety of stars (ESO PR 22/02, PR 14/03 and PR 31/03), measuring distances to stars (ESO PR 25/04), probing the innermost regions of the proto-planetary discs around young stars (ESO PR 27/04) or making the first detection by infrared interferometry of an extragalactic object (ESO PR 17/03). "Little Brothers" ESO PR Photo 07b/05 ESO PR Photo 07b/05 [Preview - JPEG: 597 x 400 pix - 47k] [Normal - JPEG: 1193 x 800 pix - 330k] [HiRes - JPEG: 5000 x 3354 pix - 10.0M] ESO PR Photo 07c/05 ESO PR Photo 07c/05

  9. Actinomycose pelvienne pseudo tumorale associée au dispositif intra-utérin: à propos de trois cas

    Science.gov (United States)

    El Hassani, Moulay Elmehdi; Babahabib, Abdellah; Kouach, Jaouad; Kassidi, Farid; El Houari, Younes; Moussaoui, Driss; Dehayni, Mohamed

    2014-01-01

    L'actinomycose est une maladie chronique suppurative granulomateuse d'origine infectieuse responsable d'un syndrome tumoral. La localisation pelvienne est rare et souvent associée, chez la femme, au port au long court du dispositif intra-utérin (DIU). Le diagnostic préopératoire n'est possible que dans 17% des cas. Nous rapportons trois observations, d'actinomycose pelvienne pseudo tumorale compliquées chez des femmes porteuses de DIU, qui illustrent le rôle de ce moyen de contraception dans la genèse de cette pathologie ainsi que les difficultés de prise en charge. PMID:25722760

  10. "Ut pictura poiesis": text i imatge, mimesi i realitat quant a «Tirant lo Blanch»

    Directory of Open Access Journals (Sweden)

    Vicent Martines

    2014-07-01

    Full Text Available The relationship between literature and reality in the Middle Ages can be considered from several dimensions. One of the most important cultural elements of the medieval period is the visual representation of reality found it literary texts, not only through the presence of miniatures in the manuscripts, but especially through the description of realia in the same text. The encyclopedic tradition helps to intertwine this close relationship between the outer representativeness and the inwardness of the text, a new interpretation of the Horacian’s ut pictura poiesis. The «Tirant lo Blanch» is a fictional text full of iconic references to contemporary reality, which in this study are made clear visually.

  11. Prise en charge du cancer du col utérin durant la grossesse: à propos de 05 cas

    OpenAIRE

    El Mazghi, Abderrahman; Bouhafa, Touria; Loukili, Kaoutar; El Kacemi, Hanan; Lalya, Issam; Hassouni, Khalid

    2014-01-01

    L'association d'un cancer du col utérin avec une grossesse est une éventualité rare. Son incidence est assez mal évaluée, elle se situe selon les études entre 1 et 2/10 000. Lorsque la découverte en est faite, il faut conjuguer deux impératifs parfois totalement divergents: le traitement de la mère et la prise en charge du foetus. Cette association pose schématiquement quatre grands problèmes, qui sont: Celui du diagnostic, qui est loin d’être évident, compte tenu des remaniements cervicaux o...

  12. The Large Millimeter Telescope (LMT)

    Science.gov (United States)

    Young, J. S.; Carrasco, L.; Schloerb, F. P.

    2002-05-01

    The Large Millimeter Telescope (LMT) project is a collaboration between the University of Massachusetts (UMass) in the USA and the Instituto Nacional de Astrofisica, Optica y Electronica (INAOE) in Mexico to build a 50m-diameter millimeter-wave antenna which will operate with good efficiency at wavelengths as short as 1 mm. The LMT is being built at an altitude of 4600 m atop Volcan Sierra Negra, an extinct volcanic peak in the state of Puebla, Mexico, approximately 100 km east of the city of Puebla. At 18 degrees 59' N latitude, the site offers an excellent view of the Galactic Center and good sky coverage of both hemispheres. Construction of the telescope is now well underway, and it is expected to be completed in late 2004. The LMT specifications call for an overall effective surface accuracy of 75 microns rms and a pointing accuracy of 1" rms. The strategy for meeting these performance goals supplements conventional antenna designs with various "active" systems to bring the final performance within the requirements. For surface accuracy, the LMT will rely on an open loop active surface which includes 180 moveable surface segments. For pointing accuracy, we will use traditional approaches supplemented by measurements to characterize the behavior of the structure, including inclinometers and temperature sensors which may be used with finite element models to determine structural deformations and predict pointing behavior. The initial complement of instruments will include a 32 element, heterodyne focal plane array at 3mm; a large format, focal plane bolometer array; a unique wide band receiver and spectrometer to determine the redshifts of primordial galaxies; and a 4 element receiver for the 1mm band. With its excellent sensitivity and angular resolution, the LMT will enable unique studies of the early universe and galaxy evolution, the interstellar medium and star formation in galaxies, and planetary science. In particular, with nearly 2000 m2 of collecting

  13. Métastase cérébrale d'un carcinome du col utérin

    Science.gov (United States)

    Chekrine, Tarik; Hassouni, Abdesalam; Jouhadi, Hassan; Sahraoui, Souha; Bouchbika, Zineb; Taleb, Amina; Benchakroun, Nadia; Tawfiq, Nezha; Benider, Abdellatif

    2013-01-01

    Les métastases cérébrales des cancers du col de l′utérus sont extrêmement rares. Elles sont généralement supra-tentorielles, survenant à un stade avancé de la maladie et dans un cadre de néoplasie polymétastatique. La tumeur primitive est le plus souvent un carcinome épidermoïde peu différencié. Leur pronostic reste sombre malgré toutes les options thérapeutiques. Vu la rareté de cet événement et le peu de cas publiés dans la littérature, nous rapportons l'observation clinique d'une jeune patiente de 44 ans, opérée pour un carcinome du col utérin et qui présente 14 mois plus tard des métastases cérébrales sus et sous tentorielles associées à des métastases ganglionnaires lombo-aortique, médiastinale et sus-claviculaire. Elle a bénéficié d'un traitement palliatif associant une chimiothérapie et une radiothérapie pan encéphalique. Devant l'altération rapide de l'état général, la patiente a été mise sous un traitement symptomatique et des soins de support. PMID:23717727

  14. PIONIER: a 4-telescope visitor instrument at VLTI

    CERN Document Server

    Bouquin, Jean-Baptiste Le; Lazareff, B; Zins, G; Haguenauer, P; Jocou, L; Kern, P; Millan-Gabet, R; Traub, W; Absil, O; Augereau, J -C; Benisty, M; Blind, N; Bonfils, X; Bourget, P; Delboulbe, A; Feautrier, P; Germain, M; Gitton, P; Gillier, D; Kiekebusch, M; Kluska, J; Knudstrup, J; Labeye, P; Lizon, J -L; Monin, J -L; Magnard, Y; Malbet, F; Maurel, D; Menard, F; Micallef, M; Michaud, L; Montagnier, G; Morel, S; Moulin, T; Perraut, K; Popovic, D; Rabou, P; Rochat, S; Rojas, C; Roussel, F; Roux, A; Stadler, E; Stefl, S; Tatulli, E; Ventura, N

    2011-01-01

    PIONIER stands for Precision Integrated-Optics Near-infrared Imaging ExpeRiment. It combines four 1.8m Auxilliary Telescopes or four 8m Unit Telescopes of the Very Large Telescope Interferometer (ESO, Chile) using an integrated optics combiner. The instrument has been integrated at IPAG starting in December 2009 and commissioned at the Paranal Observatory in October 2010. It provides scientific observations since November 2010. In this paper, we detail the instrumental concept, we describe the standard operational modes and the data reduction strategy. We present the typical performance and discuss how to improve them. This paper is based on laboratory data obtained during the integrations at IPAG, as well as on-sky data gathered during the commissioning at VLTI. We illustrate the imaging capability of PIONIER on the binaries deltaSco and HIP11231. PIONIER provides 6 visibilities and 3 independent closure phases in the H band, either in a broadband mode or with a low spectral dispersion (R=40), using natural ...

  15. ESO Telescope Designer Raymond Wilson Wins Prestigious Kavli Award for Astrophysics

    Science.gov (United States)

    2010-06-01

    with four individual telescopes with 17.5 cm thick 8.2-metre mirrors. Active optics has contributed towards making the VLT the world's most successful ground-based observatory and will be an integral part of ESO's European Extremely Large Telescope (E-ELT) project. Active optics technology is also part of the twin 10-metre Keck telescopes, the Subaru telescope's 8.2-metre mirror and the two 8.1-metre Gemini telescopes. Co-prize winners Jerry Nelson and Roger Angel respectively pioneered the use of segmentation in telescope primary mirrors - as used on the Keck telescopes, and the development of lightweight mirrors with short focal ratios. A webcast from Oslo, Norway, announcing the prize winners is available at www.kavlifoundation.org and www.kavliprize.no. More information ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  16. Innovative focal plane design for large space telescopes

    Science.gov (United States)

    Jahn, Wilfried; Ferrari, Marc; Hugot, Emmanuel

    2016-07-01

    Future large drift-scan space telescopes, providing high angular resolution and sensitive observations, require long linear focal planes covering large fields of view. In order to reach higher on-earth spatial resolution while keeping a large field of view, the use of homothetic imaging systems is prohibitive for VIS/IR applications. Based on Integral Field Unit technology developed for ground based instrumentation, we present an innovative optical system reorganizing a 1D field of view on a 2D detector array. Such a solution presents a high gain in terms of volume and weight, allowing compact cryogenic systems for IR observations.

  17. EMC Test Challenges for NASA's James Webb Space Telescope

    Science.gov (United States)

    McCloskey, John

    2016-01-01

    This presentation describes the electromagnetic compatibility (EMC) tests performed on the Integrated Science Instrument Module (ISIM), the science payload of the James Webb Space Telescope (JWST), at NASAs Goddard Space Flight Center (GSFC) in August 2015. By its very nature of being an integrated payload, it could be treated as neither a unit level test nor an integrated spacecraft observatory test. Non-standard test criteria are described along with non-standard test methods that had to be developed in order to evaluate them. Results are presented to demonstrate that all test criteria were met in less than the time allocated.

  18. EMC Test Challenges for NASAs James Webb Space Telescope

    Science.gov (United States)

    McCloskey, John

    2016-01-01

    This presentation describes the electromagnetic compatibility (EMC) tests performed on the Integrated Science Instrument Module (ISIM), the science payload of the James Webb Space Telescope (JWST), at NASAs Goddard Space Flight Center (GSFC) in August 2015. By its very nature of being an integrated payload, it could be treated as neither a unit level test nor an integrated spacecraft observatory test. Non-standard test criteria are described along with non-standard test methods that had to be developed in order to evaluate them. Results are presented to demonstrate that all test criteria were met in less than the time allocated.

  19. Spitzer Space Telescope proposal process

    Science.gov (United States)

    Laine, S.; Silbermann, N. A.; Rebull, L. M.; Storrie-Lombardi, L. J.

    2006-06-01

    This paper discusses the Spitzer Space Telescope General Observer proposal process. Proposals, consisting of the scientific justification, basic contact information for the observer, and observation requests, are submitted electronically using a client-server Java package called Spot. The Spitzer Science Center (SSC) uses a one-phase proposal submission process, meaning that fully-planned observations are submitted for most proposals at the time of submission, not months after acceptance. Ample documentation and tools are available to the observers on SSC web pages to support the preparation of proposals, including an email-based Helpdesk. Upon submission proposals are immediately ingested into a database which can be queried at the SSC for program information, statistics, etc. at any time. Large proposals are checked for technical feasibility and all proposals are checked against duplicates of already approved observations. Output from these tasks is made available to the Time Allocation Committee (TAC) members. At the review meeting, web-based software is used to record reviewer comments and keep track of the voted scores. After the meeting, another Java-based web tool, Griffin, is used to track the approved programs as they go through technical reviews, duplication checks and minor modifications before the observations are released for scheduling. In addition to detailing the proposal process, lessons learned from the first two General Observer proposal calls are discussed.

  20. Proposed National Large Solar Telescope

    Indian Academy of Sciences (India)

    Jagdev Singh

    2008-03-01

    Sun’s atmosphere is an ideal place to study and test many magnetohydrodynamic (MHD) processes controlling turbulent plasma. We wish to resolve some of the finest solar features (which remain unresolved presently) and study their dynamics. Indian Institute of Astrophysics has proposed to design, fabricate and install a 2-meter class solar telescope at a suitable site in India to resolve features on the Sun of the size of about 0.1 arcsec. The focal plane instruments will include a high resolution polarimeteric package to measure polarization with an accuracy of 0.01 per cent; a high spectral resolution spectrograph to obtain spectra in 5 widely separated absorption lines simultaneously and high spatial resolution narrow band imagers in various lines. The Himalayan region appears to be a good choice keeping in view the prevailing dry and clear weather conditions. We have started detailed analysis of the weather conditions in the area and at some other locations in India. The site characterization will be done using the Sun-photometer, S-DIMM and SHABAR techniques to determine the seeing conditions.