WorldWideScience

Sample records for unit intended primarily

  1. 21 CFR 1010.5 - Exemptions for products intended for United States Government use.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Exemptions for products intended for United States Government use. 1010.5 Section 1010.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... General Provisions § 1010.5 Exemptions for products intended for United States Government use....

  2. Complementary bipolar application specific analog semicustom array, intended to implement front-end units

    CERN Document Server

    Atkin, E; Kondratenko, S; Maslennikov, V; Meshcheriakov, V; Mishin, Yu; Volkov, Yu

    2002-01-01

    The structure of an analog semicustom array, intended to implement front-end electronics ICs on its basis, is considered. The features of this array are: implementation with an inexpensive bipolar process despite containing an equal number of NPN and PNP structures with well matched characteristics, supply voltages from 1.5 V to 15 V, transistor current gains Bst~100 and unity gain frequencies Ft > 3 GHz at collector currents of (100...300) mu A, high- and low-ohmic resistors, MOS capacitors, minimum two variable plating levels available. Specific circuit diagrams and parameters of the front-end electronics ICs, created on the basis of the considered array, are presented. The results of their tests are given. (4 refs).

  3. An annular-furnace boiler for the 660-MW power unit for ultrasupercritical parameters intended for firing brown slagging coals

    Science.gov (United States)

    Serant, F. A.; Belorutskii, I. Yu.; Ershov, Yu. A.; Gordeev, V. V.; Stavskaya, O. I.; Katsel, T. V.

    2013-12-01

    We present the main technical solutions adopted in designing annular-furnace boilers intended for operation on brown coals of the prospective Maikubensk open-cast mine in Kazakhstan as part of 660-MW power units for ultrasupercritical steam conditions. Results from 3D modeling of combustion processes are presented, which clearly show the advantages furnaces of this kind have over a traditional furnace in burning heavily slagging brown coals. The layout of the main and boiler auxiliary equipment in the existing boiler cell of the 500-MW power unit at the Ekibastuz GRES-1 district power station is shown. Appropriate attention is paid to matters concerned with decreasing harmful emissions.

  4. Intending Projects

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Project name:Jintan tire production base project (the first-phase project) Construction site:Jintan Economic Development Zone, Jiangsu Province Construction unit:Zhongce Rubber (Jintan) Co., Ltd. Total investment:RMB 2.42 billion yuan Project description:It is planned to cover an area of 3,000 mu. In the first phase, it will cover an area of 520.43 mu with designed staff of 4,500 people. It will mix 150,000 tons of rubber and produce 10 million u- nits of high-performance semi-steel-wire saloon car and light truck radial tires, 500,000 units of OTR tires and 100,000 tons of carbon black per year.

  5. 48 CFR 252.225-7004 - Report of Intended Performance Outside the United States and Canada-Submission after Award.

    Science.gov (United States)

    2010-10-01

    ... and Canada—Submission After Award (OCT 2010) (a) Definition. United States, as used in this clause... DD Form 2139; and (2) May obtain copies of DD Form 2139 from the Contracting Officer or via the Internet at http://www.dtic.mil/whs/directives/infomgt/forms/formsprogram.htm. (End of clause)...

  6. Intended Brand Associations

    DEFF Research Database (Denmark)

    Koll, Oliver; von Wallpach, Sylvia

    2014-01-01

    of actual consumer brand associations and management-intended brand associations (brand association match). The article presents results from two large-scale studies (3353 and 1201 respondents) involving one consumer goods and one service brand with multiple operationalizations of consumer response...... (attitudinal and behavioral). The results show that consumers with high brand association match show more positive brand response. However, after accounting for the valence of associations match does not add explanatory power. This outcome challenges a key foundation of brand management. The discussion......Brand managers exhibit considerable effort to define intended brand associations to anchor in consumers' minds. They follow a credo deeply rooted in branding literature: intended brand associations drive consumer response and brand equity. This article investigates the benefits of a strong overlap...

  7. 27 CFR 478.148 - Armor piercing ammunition intended for sporting or industrial purposes.

    Science.gov (United States)

    2010-04-01

    ... intended for sporting or industrial purposes. 478.148 Section 478.148 Alcohol, Tobacco Products, and... ammunition intended for sporting or industrial purposes. The Director may exempt certain armor piercing... for any such ammunition which is primarily intended for sporting purposes or intended for...

  8. 12 CFR 225.127 - Investment in corporations or projects designed primarily to promote community welfare.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Investment in corporations or projects designed... equity and debt investments in corporations or projects designed primarily to promote community welfare... not intended to limit projects under § 225.25(b)(6) to that area. Other investments primarily designed...

  9. Transition: Intended and unintended processes

    NARCIS (Netherlands)

    Ellman, M.

    2005-01-01

    An analysis of the relationship between transition as that was intended by the international financial institutions and transition as it actually happened. Attention is paid to what has been learned by experience about stabilisation, liberalisation and privatisation. Attention is also given to the

  10. Advertising, Intended vs. unintended effects of

    NARCIS (Netherlands)

    Buijzen, M.A.; Valkenburg, P.M.

    2007-01-01

    The effects of television advertising on children and adolescents can be divided into two general types: intended and unintended. Intended effects are the effects that advertisers wish to achieve with their advertisements, and unintended effects include the often-undesired side effects of advertisin

  11. Predicting Intended Unethical Behavior of Business Students

    Science.gov (United States)

    Wilson, Barbara A.

    2008-01-01

    What is the likelihood that students would intend to act unethically in the work environment? The author measured business students' intended behavior for 4 hypothetical unethical situations by investigating the following determinants: belief toward the behavior, subjective norms (i.e., pressure), perceived behavioral control, perceived personal…

  12. Advertising, Intended vs. unintended effects of

    NARCIS (Netherlands)

    Buijzen, M.A.; Valkenburg, P.M.

    2007-01-01

    The effects of television advertising on children and adolescents can be divided into two general types: intended and unintended. Intended effects are the effects that advertisers wish to achieve with their advertisements, and unintended effects include the often-undesired side effects of

  13. SU-C-BRC-01: A Monte Carlo Study of Out-Of-Field Doses From Cobalt-60 Teletherapy Units Intended for Historical Correlations of Dose to Normal Tissue

    Energy Technology Data Exchange (ETDEWEB)

    Petroccia, H [University of Florida, Gainesville, FL (United States); Olguin, E [Gainesville, FL (United States); Culberson, W [University of Wisconsin Madison, Madison, WI (United States); Bednarz, B [University of Wisconsin, Madison, WI (United States); Mendenhall, N [UF Health Proton Therapy Institute, Jacksonville, FL (United States); Bolch, W [University Florida, Gainesville, FL (United States)

    2016-06-15

    Purpose: Innovations in radiotherapy treatments, such as dynamic IMRT, VMAT, and SBRT/SRS, result in larger proportions of low-dose regions where normal tissues are exposed to low doses levels. Low doses of radiation have been linked to secondary cancers and cardiac toxicities. The AAPM TG Committee No.158 entitled, ‘Measurements and Calculations of Doses outside the Treatment Volume from External-Beam Radiation Therapy’, has been formed to review the dosimetry of non-target and out-of-field exposures using experimental and computational approaches. Studies on historical patients can provide comprehensive information about secondary effects from out-of-field doses when combined with long-term patient follow-up, thus providing significant insight into projecting future outcomes of patients undergoing modern-day treatments. Methods: We present a Monte Carlo model of a Theratron-1000 cobalt-60 teletherapy unit, which historically treated patients at the University of Florida, as a means of determining doses located outside the primary beam. Experimental data for a similar Theratron-1000 was obtained at the University of Wisconsin’s ADCL to benchmark the model for out-of-field dosimetry. An Exradin A12 ion chamber and TLD100 chips were used to measure doses in an extended water phantom to 60 cm outside the primary field at 5 and 10 cm depths. Results: Comparison between simulated and experimental measurements of PDDs and lateral profiles show good agreement for in-field and out-of-field doses. At 10 cm away from the edge of a 6×6, 10×10, and 20×20 cm2 field, relative out-of-field doses were measured in the range of 0.5% to 3% of the dose measured at 5 cm depth along the CAX. Conclusion: Out-of-field doses can be as high as 90 to 180 cGy assuming historical prescription doses of 30 to 60 Gy and should be considered when correlating late effects with normal tissue dose.

  14. Semimanufacture intended to be mounted on a vibrating wall or a vibrating panel for actively damping vibrations of the wall, wall or panel provided with such semimanufacture, system provided with a semimanufacture and a control unit, wall or panel provided with a control unit and method for damping audible vibrations of a wall or panel

    NARCIS (Netherlands)

    Goeje, de Marius; Overbeek, van Michiel Wilbert R.M.; Waal, van der Adri; Berkhoff, Arthur P.; Nederveen, Peter J.

    2006-01-01

    A semimanufacture intended to be mounted on a vibrating wall or a vibrating panel for actively damping the vibrations in the wall or the panel with frequencies which are at least partly audible, wherein the semimanufacture is provided with a plate wherein the plate is integrated with: at least one v

  15. Drunker than intended: misperceptions and information treatments

    DEFF Research Database (Denmark)

    Moxnes, Erling; Jensen, Lene

    2009-01-01

    by the difference between intended BAC and perceived BAC, and where the delay is not properly accounted for. If so, BAC will overshoot intended BAC. This hypothesis has not been thoroughly tested before; nor has the consequent and challenging educational problem. METHOD: High school students made drinking decisions...... in a laboratory experiment employing a personalized BAC simulator. A questionnaire and simulations complement the experiment. RESULTS: A long stomach delay causes much larger overshoots in BAC than a short delay. Drinking behavior is in both cases well explained by one and the same feedback strategy. Written...... information about the delay does not reduce overshoots, pre-test experience with a simulator parameterized for a mouse does. CONCLUSION: Our study warrants further studies to see if simulator training, analogies, and rules of thumb can help juveniles not to overshoot intended BAC in real drinking situations...

  16. Minorities in the United States: Guide to Resources.

    Science.gov (United States)

    Smith, Jessie Carney

    The approach of this publication to the study of minority cultures is through an introduction to the literature of certain minority groups in the United States: native Americans, black Americans, Chinese, Japanese, and Puerto Ricans. It is intended primarily as a guide for libraries, library school students, library schools, other educators, and…

  17. The Intended Image of a Place Brand

    DEFF Research Database (Denmark)

    Hannibal, Martin; Rasmussen, Erik Stavnsager

    2016-01-01

    to the historically embedded image of the municipality. In this chapter the intended image of the municipality is compared to the image as it is perceived by newcomers. The study shows that historically embedded images of places are hard to manage and change when they involve elements with negative appeal towards...

  18. Drunker than intended: misperceptions and information treatments.

    Science.gov (United States)

    Moxnes, Erling; Jensen, Lene

    2009-11-01

    Juveniles becoming overly intoxicated by alcohol is a widespread problem with consequences ranging from hangovers to deaths. We ask: could overshoots of intended levels of intoxication be triggered by misperceptions of the types found in recent studies of decision making in dynamic systems? It is well known that the dynamics of the blood alcohol concentration (BAC) is complicated by a temporary accumulation of alcohol in the stomach delaying the uptake into the blood stream. We hypothesize that juveniles use an overly simplified drinking strategy, where drinking is guided by the difference between intended BAC and perceived BAC, and where the delay is not properly accounted for. If so, BAC will overshoot intended BAC. This hypothesis has not been thoroughly tested before; nor has the consequent and challenging educational problem. High school students made drinking decisions in a laboratory experiment employing a personalized BAC simulator. A questionnaire and simulations complement the experiment. A long stomach delay causes much larger overshoots in BAC than a short delay. Drinking behavior is in both cases well explained by one and the same feedback strategy. Written information about the delay does not reduce overshoots, pre-test experience with a simulator parameterized for a mouse does. Our study warrants further studies to see if simulator training, analogies, and rules of thumb can help juveniles not to overshoot intended BAC in real drinking situations. It also implies a modification of the 'folk wisdom' of not drinking on an empty stomach.

  19. On Henselian valuations and Brauer groups of primarily quasilocal fields

    OpenAIRE

    Chipchakov, Ivan

    2011-01-01

    This paper finds a classification, up-to an isomorphism, of abelian torsion groups realizable as Brauer groups of major types of Henselian valued primarily quasilocal fields with totally indivisible value groups. When $E$ is a quasilocal field with such a valuation, it shows that the Brauer group of $E$ is divisible and embeddable in the quotient group of the additive group of rational numbers by the subgroup of integers.

  20. New symmetry of intended curved reaches

    Directory of Open Access Journals (Sweden)

    Torres Elizabeth B

    2010-04-01

    Full Text Available Abstract Background Movement regularities are inherently present in automated goal-directed motions of the primate's arm system. They can provide important signatures of intentional behaviours driven by sensory-motor strategies, but it remains unknown if during motor learning new regularities can be uncovered despite high variability in the temporal dynamics of the hand motions. Methods We investigated the conservation and violation of new movement regularity obtained from the hand motions traced by two untrained monkeys as they learned to reach outwardly towards spatial targets while avoiding obstacles in the dark. The regularity pertains to the transformation from postural to hand paths that aim at visual goals. Results In length-minimizing curves the area enclosed between the Euclidean straight line and the curve up to its point of maximum curvature is 1/2 of the total area. Similar trend is found if one examines the perimeter. This new movement regularity remained robust to striking changes in arm dynamics that gave rise to changes in the speed of the reach, to changes in the hand path curvature, and to changes in the arm's postural paths. The area and perimeter ratios characterizing the regularity co-varied across repeats of randomly presented targets whenever the transformation from posture to hand paths was compliant with the intended goals. To interpret this conservation and the cases in which the regularity was violated and recovered, we provide a geometric model that characterizes arm-to-hand and hand-to-arm motion paths as length minimizing curves (geodesics in a non-Euclidean space. Whenever the transformation from one space to the other is distance-metric preserving (isometric the two symmetric ratios co-vary. Otherwise, the symmetric ratios and their co-variation are violated. As predicted by the model we found empirical evidence for the violation of this movement regularity whenever the intended goals mismatched the actions. This

  1. Careers in virology: teaching at a primarily undergraduate institution.

    Science.gov (United States)

    Kushner, David B

    2014-10-01

    A faculty position at a primarily undergraduate institution requires working with undergraduates in both the classroom and the research lab. Graduate students and postdoctoral fellows who are interested in such a career should understand that faculty at these institutions need to teach broadly and devise research questions that can be addressed safely and with limited resources compared to a research I university. Aspects of, and ways to prepare for, this career will be reviewed herein. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

  2. Can donated media placements reach intended audiences?

    Science.gov (United States)

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer; Polonec, Lindsey

    2013-09-01

    Donated media placements for public service announcements (PSAs) can be difficult to secure, and may not always reach intended audiences. Strategies used by the Centers for Disease Control and Prevention's (CDC) Screen for Life: National Colorectal Cancer Action Campaign (SFL) to obtain donated media placements include producing a diverse mix of high-quality PSAs, co-branding with state and tribal health agencies, securing celebrity involvement, monitoring media trends to identify new distribution opportunities, and strategically timing the release of PSAs. To investigate open-ended recall of PSAs promoting colorectal cancer screening, CDC conducted 12 focus groups in three U.S. cities with men and women either nearing age 50 years, when screening is recommended to begin, or aged 50-75 years who were not in compliance with screening guidelines. In most focus groups, multiple participants recalled exposure to PSAs promoting colorectal cancer screening, and most of these individuals reported having seen SFL PSAs on television, in transit stations, or on the sides of public buses. Some participants reported exposure to SFL PSAs without prompting from the moderator, as they explained how they learned about the disease. Several participants reported learning key campaign messages from PSAs, including that colorectal cancer screening should begin at age 50 years and screening can find polyps so they can be removed before becoming cancerous. Donated media placements can reach and educate mass audiences, including millions of U.S. adults who have not been screened appropriately for colorectal cancer.

  3. Plans should abstractly describe intended behavior

    Energy Technology Data Exchange (ETDEWEB)

    Pfleger, K.; Hayes-Roth, B. [Stanford Univ., CA (United States)

    1996-12-31

    Planning is the process of formulating a potential course of action. How courses of action (plans) produced by a planning module are represented and how they are used by execution-oriented modules of a complex agent to influence or dictate behavior are critical architectural issues. In contrast to the traditional model of plans as executable programs that dictate precise behaviors, we claim that autonomous agents inhabiting dynamic, unpredictable environments can make better use of plans that only abstractly describe their intended behavior. Such plans only influence or constrain behavior, rather than dictating it. This idea has been discussed in a variety of contexts, but it is seldom incorporated into working complex agents. Experiments involving instantiations of our Adaptive Intelligent Systems architecture in a variety of domains have demonstrated the generality and usefulness of the approach, even with our currently simple plan representation and mechanisms for plan following. The behavioral benefits include (1) robust improvisation of goal-directed behavior in response to dynamic situations, (2) ready exploitation of dynamically acquired knowledge or behavioral capabilities, and (3) adaptation based on dynamic aspects of coordinating diverse behaviors to achieve multiple goals. In addition to these run-time advantages, the approach has useful implications for the design and configuration of agents. Indeed, the core ideas of the approach are natural extensions of fundamental ideas in software engineering.

  4. Exploring intended infant feeding decisions among low-income women.

    Science.gov (United States)

    Gurka, Kelly K; Hornsby, Paige P; Drake, Emily; Mulvihill, Evan M; Kinsey, Emily N; Yitayew, Miheret S; Lauer, Claire; Corriveau, Sharon; Coleman, Valerie; Gulati, Guari; Kellams, Ann L

    2014-10-01

    Low-income women have the lowest rates of breastfeeding in the United States. Greater understanding of factors that predict intention to feed artificial breastmilk substitute is needed to inform the design and timing of interventions to promote breastfeeding among vulnerable women. This study aimed to identify demographic and reproductive characteristics and other factors associated with intent to feed artificial breastmilk substitute among low-income women. Data from 520 low-income women interviewed at 24-41 weeks of gestation during enrollment in a prenatal breastfeeding education intervention study were analyzed. Participant characteristics, reasons for feeding decision, and sources and types of information received were compared among women intending to feed only artificial breastmilk substitute and other women. Most participants (95%) had already chosen an infant feeding method at the time of interview. There were no differences in plans to return to work by feeding plan. Women reporting intention to feed only artificial breastmilk substitute were less likely to report receiving information about the benefits of breastfeeding, how to breastfeed, and pumps and were more likely to cite personal preference and convenience as reasons for their decision. Women were more likely to intend to feed artificial breastmilk substitute if they had a previous live birth or had not breastfed a child, including the most recent. These findings suggest breastfeeding promotion should target women early and include sensitive, effective ways to promote breastfeeding among women who have not previously successfully breastfed. Breastfeeding history should be elicited, and plans to pump should be supported prenatally.

  5. Human punishment is not primarily motivated by inequality

    Science.gov (United States)

    Marczyk, Jesse

    2017-01-01

    Previous theorizing about punishment has suggested that humans desire to punish inequality per se. However, the research supporting such an interpretation contains important methodological confounds. The main objective of the current experiment was to remove those confounds in order to test whether generating inequality per se is punished. Participants were recruited from an online market to take part in a wealth-alteration game with an ostensible second player. The participants were given an option to deduct from the other player’s payment as punishment for their behavior during the game. The results suggest that human punishment does not appear to be motivated by inequality per se, as inequality that was generated without inflicting costs on others was not reliably punished. Instead, punishment seems to respond primarily to the infliction of costs, with inequality only becoming relevant as a secondary input for punishment decisions. The theoretical significance of this finding is discussed in the context of its possible adaptive value. PMID:28187166

  6. Primarily nonlinear effects observed in a driven asymmetrical vibrating wire

    Science.gov (United States)

    Hanson, Roger J.; Macomber, H. Kent; Morrison, Andrew C.; Boucher, Matthew A.

    2005-01-01

    The purpose of the work reported here is to further experimentally explore the wide variety of behaviors exhibited by driven vibrating wires, primarily in the nonlinear regime. When the wire is driven near a resonant frequency, it is found that most such behaviors are significantly affected by the splitting of the resonant frequency and by the existence of a ``characteristic'' axis associated with each split frequency. It is shown that frequency splitting decreases with increasing wire tension and can be altered by twisting. Two methods are described for determining the orientation of characteristic axes. Evidence is provided, with a possible explanation, that each axis has the same orientation everywhere along the wire. Frequency response data exhibiting nonlinear generation of transverse motion perpendicular to the driving direction, hysteresis, linear generation of perpendicular motion (sometimes tubular), and generation of motion at harmonics of the driving frequency are exhibited and discussed. Also reported under seemingly unchanging conditions are abrupt large changes in the harmonic content of the motion that sometimes involve large subharmonics and harmonics thereof. Slow transitions from one stable state of vibration to another and quasiperiodic motions are also exhibited. Possible musical significance is discussed. .

  7. 21 CFR 177.2600 - Rubber articles intended for repeated use.

    Science.gov (United States)

    2010-04-01

    ...-acrylonitrile-ethylene glycol dimethacrylate copolymers containing not more than 5 weight percent of polymer units derived from ethylene glycol dimethacrylate. Butadiene-acrylonitrile-methacrylic acid copolymer... production of rubber articles intended for repeated use shall not exceed the amount reasonably required to...

  8. Potentially inappropriate prescribing of primarily renally cleared medications for older veterans affairs nursing home patients.

    Science.gov (United States)

    Hanlon, Joseph T; Wang, Xiaoqiang; Handler, Steven M; Weisbord, Steven; Pugh, Mary Jo; Semla, Todd; Stone, Roslyn A; Aspinall, Sherrie L

    2011-06-01

    Inappropriate prescribing of primarily renally cleared medications in older patients with kidney disease can lead to adverse outcomes. To estimate the prevalence of potentially inappropriate prescribing of 21 primarily renally cleared medications based on 2 separate estimates of renal function and to identify factors associated with this form of suboptimal prescribing in older VA nursing home (NH) patients. Longitudinal study Participants were 1304 patients, aged 65 years or older, admitted between January 1, 2004, and June 30, 2005, for 90 days or more to 1 of 133 VA NHs. Potentially inappropriate prescribing of primarily renally cleared medications determined by estimating creatinine clearance using the Cockcroft Gault (CG) and Modification of Diet in Renal Disease (MDRD) equations and applying explicit guidelines for contraindicated medications and dosing. The median estimated creatinine clearance via CG was 67 mL/min, whereas it was 80 mL/min/1.73m(2) with the MDRD. Overall, 11.89% patients via CG and only 5.98% via MDRD had evidence of potentially inappropriate prescribing of at least 1 renally cleared medication. The most commonly involved medications were ranitidine, glyburide, gabapentin, and nitrofurantoin. Factors associated with potentially inappropriate prescribing as per the CG were age older than 85 (adjusted odds ratio [AOR] 4.24, 95% confidence interval [CI] 2.42-7.43), obesity (AOR 0.26, 95% CI 0.14-0.50) and having multiple comorbidities (AOR 1.09 for each unit increase in the Charlson comorbidity index, 95% CI 1.01-1.19). Potentially inappropriate prescribing of renally cleared medications is common in older VA NH patients. Intervention studies to improve the prescribing of primarily renally cleared medications in nursing homes are needed. Copyright © 2011 American Medical Directors Association. Published by Elsevier Inc. All rights reserved.

  9. 21 CFR 1010.20 - Electronic products intended for export.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Electronic products intended for export. 1010.20 Section 1010.20 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Electronic Products § 1010.20 Electronic products intended for export. The performance standards...

  10. Freestanding midwifery units versus obstetric units

    DEFF Research Database (Denmark)

    Overgaard, Charlotte; Fenger-Grøn, Morten; Sandall, Jane

    2012-01-01

    women intending to give birth in two freestanding midwifery units (FMU) versus two obstetric units in Denmark differed by level of social disadvantage Methods The study was designed as a cohort study with a matched control group. It included 839 lowrisk women intending to give birth in an FMU, who were...... prospectively and individually matched on nine selected obstetric/socio-economic factors to 839 low-risk women intending OU birth. Educational level was chosen as a proxy for social position. Analysis was by intention-to-treat. Results Women intending to give birth in an FMU had a significantly higher...

  11. Small-Volume Injections: Evaluation of Volume Administration Deviation From Intended Injection Volumes.

    Science.gov (United States)

    Muffly, Matthew K; Chen, Michael I; Claure, Rebecca E; Drover, David R; Efron, Bradley; Fitch, William L; Hammer, Gregory B

    2017-10-01

    In the perioperative period, anesthesiologists and postanesthesia care unit (PACU) nurses routinely prepare and administer small-volume IV injections, yet the accuracy of delivered medication volumes in this setting has not been described. In this ex vivo study, we sought to characterize the degree to which small-volume injections (≤0.5 mL) deviated from the intended injection volumes among a group of pediatric anesthesiologists and pediatric postanesthesia care unit (PACU) nurses. We hypothesized that as the intended injection volumes decreased, the deviation from those intended injection volumes would increase. Ten attending pediatric anesthesiologists and 10 pediatric PACU nurses each performed a series of 10 injections into a simulated patient IV setup. Practitioners used separate 1-mL tuberculin syringes with removable 18-gauge needles (Becton-Dickinson & Company, Franklin Lakes, NJ) to aspirate 5 different volumes (0.025, 0.05, 0.1, 0.25, and 0.5 mL) of 0.25 mM Lucifer Yellow (LY) fluorescent dye constituted in saline (Sigma Aldrich, St. Louis, MO) from a rubber-stoppered vial. Each participant then injected the specified volume of LY fluorescent dye via a 3-way stopcock into IV tubing with free-flowing 0.9% sodium chloride (10 mL/min). The injected volume of LY fluorescent dye and 0.9% sodium chloride then drained into a collection vial for laboratory analysis. Microplate fluorescence wavelength detection (Infinite M1000; Tecan, Mannedorf, Switzerland) was used to measure the fluorescence of the collected fluid. Administered injection volumes were calculated based on the fluorescence of the collected fluid using a calibration curve of known LY volumes and associated fluorescence.To determine whether deviation of the administered volumes from the intended injection volumes increased at lower injection volumes, we compared the proportional injection volume error (loge [administered volume/intended volume]) for each of the 5 injection volumes using a linear

  12. Examining Students' Intended Image on Facebook: "What Were They Thinking?!"

    Science.gov (United States)

    Peluchette, Joy; Karl, Katherine

    2010-01-01

    The present article examines factors that influence why students post information on their social network profile which employers would find inappropriate. Results show that many students make a conscious attempt to portray a particular image and, as predicted, their intended image was related to whether they posted inappropriate information.…

  13. The intended and unintended effects of advertising on children

    NARCIS (Netherlands)

    Buijzen, M.A.; Valkenburg, P.M.

    2013-01-01

    The effects of advertising on children have often been divided into two general types: intended effects (e.g., children's brand awareness, preferences, and purchase requests) and unintended effects (e.g., materialistic orientations, parent–child conflicts, and unhealthy eating habits). The first par

  14. Intending the Faculty and its Relation with the City

    NARCIS (Netherlands)

    Vande Putte, H.

    2014-01-01

    This paper presents an analysis of the preparation of the idea competition 'Building for Bouwkunde' that was held in 2008. The competition intended entrants to design a replacement building for the lost building of the Faculty of Architecture of the Delft University of Technology, based on the refle

  15. The intended and unintended effects of advertising on children

    NARCIS (Netherlands)

    Buijzen, M.A.; Valkenburg, P.M.

    2013-01-01

    The effects of advertising on children have often been divided into two general types: intended effects (e.g., children's brand awareness, preferences, and purchase requests) and unintended effects (e.g., materialistic orientations, parent–child conflicts, and unhealthy eating habits). The first par

  16. The Intended and Unintended Consequences of International Service-Learning

    Science.gov (United States)

    Crabtree, Robbin D.

    2013-01-01

    Previous research on service-learning in international contexts tends to focus on the benefits and outcomes for students and educational institutions. This essay is intended to provoke further examination of issues related to university-community engagement in global contexts, particularly in terms of the consequences for host communities. In…

  17. The intended and unintended effects of advertising on children

    NARCIS (Netherlands)

    Buijzen, M.; Valkenburg, P.M.; Valdivia, A.N.; Scharrer, E.

    2013-01-01

    The effects of advertising on children have often been divided into two general types: intended effects (e.g., children's brand awareness, preferences, and purchase requests) and unintended effects (e.g., materialistic orientations, parent-child conflicts, and unhealthy eating habits). The first par

  18. How Dogs Know when Communication Is Intended for Them

    Science.gov (United States)

    Kaminski, Juliane; Schulz, Linda; Tomasello, Michael

    2012-01-01

    Domestic dogs comprehend human gestural communication in a way that other animal species do not. But little is known about the specific cues they use to determine when human communication is intended for them. In a series of four studies, we confronted both adult dogs and young dog puppies with object choice tasks in which a human indicated one of…

  19. How Dogs Know when Communication Is Intended for Them

    Science.gov (United States)

    Kaminski, Juliane; Schulz, Linda; Tomasello, Michael

    2012-01-01

    Domestic dogs comprehend human gestural communication in a way that other animal species do not. But little is known about the specific cues they use to determine when human communication is intended for them. In a series of four studies, we confronted both adult dogs and young dog puppies with object choice tasks in which a human indicated one of…

  20. The intended and unintended effects of advertising on children

    NARCIS (Netherlands)

    Buijzen, M.; Valkenburg, P.M.; Valdivia, A.N.; Scharrer, E.

    2013-01-01

    The effects of advertising on children have often been divided into two general types: intended effects (e.g., children's brand awareness, preferences, and purchase requests) and unintended effects (e.g., materialistic orientations, parent-child conflicts, and unhealthy eating habits). The first par

  1. Examining Students' Intended Image on Facebook: "What Were They Thinking?!"

    Science.gov (United States)

    Peluchette, Joy; Karl, Katherine

    2010-01-01

    The present article examines factors that influence why students post information on their social network profile which employers would find inappropriate. Results show that many students make a conscious attempt to portray a particular image and, as predicted, their intended image was related to whether they posted inappropriate information.…

  2. Intending the Faculty and its Relation with the City

    NARCIS (Netherlands)

    Vande Putte, H.

    2014-01-01

    This paper presents an analysis of the preparation of the idea competition 'Building for Bouwkunde' that was held in 2008. The competition intended entrants to design a replacement building for the lost building of the Faculty of Architecture of the Delft University of Technology, based on the

  3. Predictors of nephrectomy in high grade blunt renal trauma patients treated primarily with conservative intent.

    Science.gov (United States)

    Prasad, Narla Hari; Devraj, Rahul; Chandriah, G Ram; Sagar, S Vidya; Reddy, Ch Ram; Murthy, Pisapati Venkata Lakshmi Narsimha

    2014-04-01

    There is no consensus on the optimal management of high grade renal trauma. Delayed surgery increases the likelihood of secondary hemorrhage and persistent urinary extravasation, whereas immediate surgery results in high renal loss. Hence, the present study was undertaken to evaluate the predictors of nephrectomy and outcome of high Grade (III-V) renal injury, treated primarily with conservative intent. The records of 55 patients who were admitted to our institute with varying degrees of blunt renal trauma from January 2005 to December 2012 were retrospectively reviewed. Grade III-V renal injury was defined as high grade blunt renal trauma and was present in 44 patients. The factors analyzed to predict emergency intervention were demographic profile, grade of injury, degree of hemodynamic instability, requirement of blood transfusion, need for intervention, mode of intervention, and duration of intensive care unit stay. Rest of the 40 patients with high grade injury (grade 3 and 4)did not require emergency intervention and underwent a trail of conservative management. 7 of the 40 patients with high grade renal injury (grade 3 and 4), who were managed conservatively experienced complications requiring procedural intervention and three required a delayed nephrectomy. Presence of grade V injuries with hemodynamic instability and requirement of more than 10 packed cell units for resuscitation were predictors of nephrectomy. Predictors of complications were urinary extravasation and hemodynamic instability at presentation. Majority of the high grade renal injuries can be successfully managed conservatively. Grade V injuries and the need for more packed cell transfusions during resuscitation predict the need for emergency intervention.

  4. Predictors of nephrectomy in high grade blunt renal trauma patients treated primarily with conservative intent

    Directory of Open Access Journals (Sweden)

    Narla Hari Prasad

    2014-01-01

    Full Text Available Introduction: There is no consensus on the optimal management of high grade renal trauma. Delayed surgery increases the likelihood of secondary hemorrhage and persistent urinary extravasation, whereas immediate surgery results in high renal loss. Hence, the present study was undertaken to evaluate the predictors of nephrectomy and outcome of high Grade (III-V renal injury, treated primarily with conservative intent. Materials and Methods: The records of 55 patients who were admitted to our institute with varying degrees of blunt renal trauma from January 2005 to December 2012 were retrospectively reviewed. Grade III-V renal injury was defined as high grade blunt renal trauma and was present in 44 patients. The factors analyzed to predict emergency intervention were demographic profile, grade of injury, degree of hemodynamic instability, requirement of blood transfusion, need for intervention, mode of intervention, and duration of intensive care unit stay. Results: Rest of the 40 patients with high grade injury (grade 3 and 4 did not require emergency intervention and underwent a trail of conservative management. 7 of the 40 patients with high grade renal injury (grade 3 and 4, who were managed conservatively experienced complications requiring procedural intervention and three required a delayed nephrectomy. Presence of grade V injuries with hemodynamic instability and requirement of more than 10 packed cell units for resuscitation were predictors of nephrectomy. Predictors of complications were urinary extravasation and hemodynamic instability at presentation. Conclusion: Majority of the high grade renal injuries can be successfully managed conservatively. Grade V injuries and the need for more packed cell transfusions during resuscitation predict the need for emergency intervention.

  5. Completed egoism and intended altruism boost healthy food choices.

    Science.gov (United States)

    Weibel, Christian; Messner, Claude; Brügger, Adrian

    2014-06-01

    Based on the self-licensing literature and goal theory, we expected and found that completed (im)moral actions lead to markedly different food choices (Studies 1 & 2) than intended (im)moral actions (Study 2). In Study 1, people more often chose healthy over unhealthy food options when they recalled a completed egoistic action than when they recalled a completed altruistic action. Study 2 confirmed this finding and furthermore showed that the self-licensing effect in food choices is moderated by the action stage (completed versus intended) of the moral or immoral action. This article extends the existing self-licensing literature and opens up new perspectives for changing consumers' food consumption behavior. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Use of metakaolin in grouts intended for soil nailing

    Directory of Open Access Journals (Sweden)

    Husson B.

    2012-09-01

    Full Text Available The aim of this work was to carry out a feasibility study to evaluate the pertinence of using metakaolin in grout intended for soil nailing. After a first step of grout optimisation based on technical and environmental constraints, an in-situ study was performed to evaluate the compatibility of metakaolin with this kind of application. This part highlights the minimum performance levels necessary if grout is to fulfil its role of transferring stresses between soil and nail.

  7. Screening tests for intended medication adherence among the elderly.

    Science.gov (United States)

    Raehl, Cynthia L; Bond, C A; Woods, Tresa J; Patry, Roland A; Sleeper, Rebecca B

    2006-05-01

    Medication nonadherence is increasingly recognized as a cause of preventable adverse events, hospitalizations, and poor healthcare outcomes. While comprehensive medication adherence assessment for the elderly is likely to identify and prevent drug-related problems, it is time consuming for patient and healthcare providers alike. To identify screening tools to predict elderly patients' intended medication adherence that are suitable for primary-care settings and community pharmacies. This study evaluated 57 English-speaking persons aged 65 years and older who were from diverse socioeconomic backgrounds. Intended adherence was quantified, and the relationships to demographic, medical history, socioeconomic, and literacy variables were determined. In a multivariate analysis with the composite MedTake Test (a quantitative measure of each subject's intent to adhere to prescribed oral medications) as the dependent variable, independent predictors of intended adherence included: age, car ownership in the last 10 years, receipt of food assistance in the last 10 years, number of over-the-counter (OTC) medicines, and REALM (Rapid Estimate of Adult Literacy in Medicine). The strongest predictor was the REALM word-recognition pronunciation test (beta = 0.666; R2 = 0.271; p pronunciation test, along with age, number of OTC drugs, and 2 socioeconomic questions, predicted the intent of seniors to correctly take their own prescribed oral medications.

  8. Pituitary tumor disappearance in a patient with newly diagnosed acromegaly primarily treated with octreotide LAR.

    Science.gov (United States)

    Resmini, E; Murialdo, G; Giusti, M; Boschetti, M; Minuto, F; Ferone, D

    2005-02-01

    We describe the case of an acromegalic patient primarily treated with octreotide LAR in whom the pituitary tumor disappeared after 18 months of treatment. A 68-yr-old woman, with clinical suspicion of acromegaly, was admitted to our Unit with the ultrasonographical evidence of cardiac hypertrophy, arrhythmias, right branch block and interatrial septum aneurism. She referred hands and feet enlargement since the age of 30 and facial disfigurements since the age of 50. At the age of 45 she underwent surgery for carpal tunnel syndrome and at the age of 61 an euthyroid nodular goiter was diagnosed. Hormonal evaluation showed elevated circulating GH levels (25+/-3.2 ng/ml), not suppressible after oral glucose load, and elevated IGF-I levels (646 ng/ml), whereas the remaining pituitary function was normal. Visual perimetry was normal, whereas magnetic resonance imaging (MRI) showed an intrasellar pituitary adenoma with maximal diameter of 9 mm. In order to improve cardiovascular function before surgery, the patient started octreotide LAR 20 mg every 4 weeks for 3 months. Then based on IGF-I values, the dose was adjusted to 30 mg. After 6 months a second MRI showed significant tumor reduction (>50% of baseline maximal diameter), GH and IGF-I were within the normal range and the patient continued the treatment. After one-year therapy, an improvement of cardiac alterations was recorded and the patient was referred to the neurosurgeon. However, she refused the operation. At 18-month follow-up, MRI showed the complete disappearance of direct and indirect signs of pituitary adenoma. To our knowledge, this is the first case of complete radiological remission of pituitary tumor during octreotide LAR treatment in acromegaly.

  9. Twitter manager GO API intended for GNU Social API

    OpenAIRE

    Janiga, Jaroslav

    2015-01-01

    The bachelor’s thesis had two goals. The first one was to create API for GO programming language that communicates with GNU Social API. The second one was to create an application that uses the mentioned API. The main purpose of creating the application was to reduce the time spent with the login and logout of the accounts by the members in the white team. The application is intended for training purposes in JYVSECTEC project at JAMK University of Applied Sciences. JYVSECTEC sta...

  10. The Selfish Goal: Unintended Consequences of Intended Goal Pursuits.

    Science.gov (United States)

    Bargh, John A; Green, Michelle; Fitzsimons, Gráinne

    2008-10-01

    Three experiments tested the hypothesis that consciously intended goal pursuits have unintended consequences for social judgment and behavior. From evolutionary theory (Dawkins 1976/2006) and empirical evidence of a nonconscious mode of goal pursuit (Bargh, 2005) we derive the hypothesis that most human goal pursuits are open-ended in nature: Once active, goals will operate on goal-relevant content in the environment, even if that content is not the intended focus of the conscious goal. Experiments 1 and 2 demonstrate that goals to evaluate a job applicant for either a waiter or crime reporter position also shape impressions of incidental bystanders in the situation, such that the bystander is later liked or disliked not on his own merits, but on how well his behavior matches the criteria consciously applied in evaluating the job applicant. Experiment 3 finds that a goal to help a specific target person spills over to influence actions toward incidental bystanders, but only while active. Implications of these findings for goal pursuit in everyday life are discussed.

  11. Activity-based Calculation Models for the Brazilian Air Force Cellular Unit of Intendancy

    Science.gov (United States)

    2013-03-01

    only 10 hours to assemble the MSE. For the health care team to work with tranquility and comfort, twelve other military took care of every detail...being of the troops. Small gestures made the difference in the journey of more than ten hours of work: "hot chocolate on cold and rainy afternoons...characteristics, benefits , steps of implementation, and the relationship between them. These tools will provide means to answer the Primary Research

  12. Intended and unintended consequences of China's zero markup drug policy.

    Science.gov (United States)

    Yi, Hongmei; Miller, Grant; Zhang, Linxiu; Li, Shaoping; Rozelle, Scott

    2015-08-01

    Since economic liberalization in the late 1970s, China's health care providers have grown heavily reliant on revenue from drugs, which they both prescribe and sell. To curb abuse and to promote the availability, safety, and appropriate use of essential drugs, China introduced its national essential drug list in 2009 and implemented a zero markup policy designed to decouple provider compensation from drug prescription and sales. We collected and analyzed representative data from China's township health centers and their catchment-area populations both before and after the reform. We found large reductions in drug revenue, as intended by policy makers. However, we also found a doubling of inpatient care that appeared to be driven by supply, instead of demand. Thus, the reform had an important unintended consequence: China's health care providers have sought new, potentially inappropriate, forms of revenue. Project HOPE—The People-to-People Health Foundation, Inc.

  13. Graphite Intended for Green Engineering Developed by Noncontaminant Reverse Abrasion

    Directory of Open Access Journals (Sweden)

    Roberto Baca Arroyo

    2016-01-01

    Full Text Available Graphite intended for green engineering was synthesized by noncontaminant reverse abrasion, which consists of graphite layers assembled with thickness controlled on SiC sandpaper as insulating substrate. Phase formation of the graphite layers was validated by X-ray diffraction studies and its finished profile by Atomic Force Microscopy (AFM. Transport parameters of only three layers were evaluated from current-voltage curves. Mathematical functions such as derivative and modulation of a signal have been built by graphite circuits using different performance principles, compared to those used with silicon devices. The trends related to electronic engineering should be achieved with design of the graphite-based devices to facilitate their mass production in the near future.

  14. New process of silicon carbide purification intended for silicon passivation

    Science.gov (United States)

    Barbouche, M.; Zaghouani, R. Benabderrahmane; Benammar, N. E.; Aglieri, V.; Mosca, M.; Macaluso, R.; Khirouni, K.; Ezzaouia, H.

    2017-01-01

    In this work, we report on a new, efficient and low cost process of silicon carbide (SiC) powder purification intended to be used in photovoltaic applications. This process consists on the preparation of porous silicon carbide layers followed by a photo-thermal annealing under oxygen atmosphere and chemical treatment. The effect of etching time on impurities removal efficiency was studied. Inductively coupled plasma atomic emission spectrometry (ICP-AES) results showed that the best result was achieved for an etching time of 10 min followed by gettering at 900 °C during 1 h. SiC purity is improved from 3N (99.9771%) to 4N (99.9946%). Silicon carbide thin films were deposited onto silicon substrates by pulsed laser deposition technique (PLD) using purified SiC powder as target. Significant improvement of the minority carrier lifetime was obtained encouraging the use of SiC as a passivation layer for silicon.

  15. Siloxanes in silicone products intended for food contact

    DEFF Research Database (Denmark)

    Cederberg, Tommy Licht; Jensen, Lisbeth Krüger

    Silicone is used in food contact materials due to its excellent physical and chemical properties. It is thermostable and flexible and is used in bakeware and kitchen utensils. Silicone is also used to coat paper to make it water and fat resistant. There is no specific regulation in EU which covers...... silicone as food contact materials, but in Regulation 1935/2004 on materials intended to come into contact with food it is stated that materials should be manufactured so it do not transfer their constituents to food in quantities which could endanger human health. Silicone may contain residual siloxane...... oligomers which might migrate to the food when the product is being used. DTU has proposed two action limits for low molecular weight siloxanes in food contact materials. For the sum of cyclic siloxanes D3 to D8 the limits are 12 mg/kg food for adults and 2 mg/kg food for children. For the sum of cyclic...

  16. Red blood cells intended for transfusion : quality criteria revisited

    NARCIS (Netherlands)

    Hogman, CF; Meryman, HT

    2006-01-01

    Great variation exists with respect to viability and function of fresh and stored red blood cells (RBCs) as well as of the contents of RBC hemoglobin (Hb) in individual units. Improved technology is available for the preparation as well as the storage of RBCs. The authors raise the question whether

  17. What do native manufacturers intend to do in 2007?

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    SAIC SAIC saw its total sales reach 1,340,000 units last year, including 911,000 passenger cars (413,400 from Shanghai GM and 352,000 by Shanghai VW). It is going to consolidate its leading role by perfecting brand management and strengthening the R& D.

  18. Characterization and modeling of uncertainty intended for a secured MANET

    Directory of Open Access Journals (Sweden)

    Md. Amir Khusru Akhtar

    2013-08-01

    Full Text Available Mobile ad-hoc network is a chaos for decades due to its dynamic and heuristic base. It employs several forms of uncertainty such as vagueness and imprecision. Vagueness can be taken in terms of linguistic assumptions such as grading and classification for the acceptance. Imprecision on the other hand can be associated with countable or noncountable assumptions such as the weights of acceptance calculated by the members of the MANET. This paper presents “Certainty Intended Model (CIM” for a secured MANET by introducing one or more expert nodes together with the inclusion of various theories (such as monotone measure, belief, plausibility, evidence. These theories can be used for the characterization and modeling various forms of uncertainty. Further, these characterizations help in quantifying the uncertainty spectrum because, as much information about the problem is available we can transform from one theory to another. In this work we have shown how these theories and expert opinion helps to identify the setback associated with the MANET in respect of trust management and finally, enhances the security, reliability and performance of the MANET.

  19. [Biological evaluation of a protein mixture intended for enteral nutrition].

    Science.gov (United States)

    Meneses, J Olza; Foulquie, J Porres; Valero, G Urbano; de Victoria, E Martínez; Hernández, A Gil

    2008-01-01

    Enteral nutrition is the best way to feed or supplement the diet when gastrointestinal tract functions of patients are partially or totally preserved. Whenever total enteral nutrition is needed, it represents the only source of nutrients for patients. Thus, it is mandatory to ensure that high biological value proteins are included in enteral formulae. To assess the biological quality of a protein blend constituted by 50% potassium caseinate, 25% whey protein and 25% pea protein intended to be used in enteral nutrition products. Forty Wistar rats (20 male and 20 female), with initial body weight of 51 g, where divided into four groups and feed for 10 days with: casein (Control), experimental protein blend (Experimental), liophylized normo- and hyperproteic enteral nutrition formulae adapted to the animal nutritional requirements (Normoproteic and Hyperproteic). Protein efficiency ratio (PER), apparent digestibility coefficient (ADC), relationship between retained and absorbed nitrogen (R/A) and relationship between retained and consumed nitrogen (R/I) where calculated. Experimental and control groups had similar values for all analysed indices (PER, ADC, R/A and R/I). These indices where also similar between normo and hyperproteic groups, but lower than experimental and control groups, except in PER, where normoproteic group was either similar to control and hiperproteic group. The quality of the protein blend used in this study is high. It is a good protein source to be used in the development of new enteral nutritional products.

  20. Identity-Related Influences on the Success of Minority Workers in Primarily Nonminority Organizations.

    Science.gov (United States)

    James, Keith; Khoo, Gillian

    1991-01-01

    Reviews literature at the micro- (individual, interpersonal, and small group) and macro- (organizational, societal, and cultural) levels relating to the experiences and outcomes of minorities in work settings populated primarily by members of the majority. Uses Tajfel and Turner's Social Identity Theory as an organizational and integrative…

  1. 29 CFR 780.607 - “Primarily employed” in agriculture.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âPrimarily employedâ in agriculture. 780.607 Section 780... AGRICULTURE, PROCESSING OF AGRICULTURAL COMMODITIES, AND RELATED SUBJECTS UNDER THE FAIR LABOR STANDARDS ACT Employment in Agriculture and Livestock Auction Operations Under the Section 13(b)(13) Exemption Requirements...

  2. Propulsion and control propellers with thruster nozzles primarily for aircraft applications

    Science.gov (United States)

    Pabst, W.

    1986-01-01

    A propulsion and control propeller with thruster nozzles, primarily for aircraft application is described. Adjustability of rotor blades at the hub and pressurized gas expulsion combined with an air propeller increase power. Both characteristics are combined in one simple device, and, furthermore, incorporate overall aircraft control so that mechanisms which govern lateral and horizontal movement become superfluous.

  3. Examining the Effects of Introducing Online Access to ACS Journals at Primarily Undergraduate Institutions

    Science.gov (United States)

    Landolt, R. G.

    2007-01-01

    In collaboration with the Publications Division of the American Chemical Society (ACS), students and faculty at 24 primarily undergraduate institutions were provided online access to ACS primary research journals for a period of 18 months, and a group of eight schools were granted access to use the archives of ACS journals for a year. Resources…

  4. Carbon Geography. The political economy of congressional support for legislation intended to mitigate greenhouse gas production

    Energy Technology Data Exchange (ETDEWEB)

    CRAGG, MICHAEL I.; ZHOU, YUYU; GURNEY, KEVIN; KAHN, MATTHEW E.

    2012-04-20

    Over the last five years, the U.S Congress has voted on several pieces of legislation intended to sharply reduce the nation’s greenhouse gas emissions. Given that climate change is a world public bad, standard economic logic would predict that the United States would -free rideII and wait for other nations to reduce their emissions. Within the Congress, there are clear patterns to who votes in favor of mitigating greenhouse gas emissions. This paper presents a political economy analysis of the determinants of pro-greenII votes on such legislation. Conservatives consistently vote against such legislation. Controlling for a Representative’s ideology, representatives from richer districts and districts with a lower per-capita carbon dioxide footprint are more likely to vote in favor of climate change mitigation legislation. Representatives from districts where industrial emissions represent a larger share of greenhouse gas emissions are more likely to vote no.

  5. Sand Fences in the Coastal Zone: Intended and Unintended Effects

    Science.gov (United States)

    Grafals-Soto, Rosana; Nordstrom, Karl

    2009-09-01

    Sand-trapping fences modify the character of the coastal landscape and change its spatial structure, image, and meaning. This paper examines the relationship between these changes and fence usage at the municipal level, where most decisions about fence deployment are made. Use of fences in 29 municipalities on the developed coast of New Jersey is examined over a 6-year period. Interviews with municipal officers indicate that wooden slat sand-trapping fences are used primarily to build dunes to provide protection against wave uprush and flooding, but they are also used to control pedestrian traffic and demarcate territory. These uses result in changes in landforms and habitats. An aerial video inventory of fences taken in 2002 indicates that 82% of the shoreline had fences and 72% had dunes. Single and double straight fence rows are the most commonly used. Fences are often built to accomplish a specific primary purpose, but they can cause many different and often unanticipated changes to the landscape. The effects of a sand fence change through time as the initial structure traps sand, creates a dune that is colonized by vegetation, and becomes integrated into the environment by increasing topographic variability and aesthetic and habitat value. Sand fences can be made more compatible with natural processes by not placing them in locations where sources of wind blown sand are restricted or in unnatural shore perpendicular orientations. Symbolic fences are less expensive, are easy to replace when damaged, are less visually intrusive, and can be used for controlling pedestrian access.

  6. Conflict Resolution Unit.

    Science.gov (United States)

    Busselle, Tish

    This 7-day unit, intended for use with secondary students, contains a statement of rationale and objectives, lesson plans, class assignments, teacher and student bibliographies, and suggestions for instructional materials on conflict resolution between individuals, groups, and nations. Among the six objectives listed for the unit are: 1) explain…

  7. Writer's cramp: increased dorsal premotor activity during intended writing.

    Science.gov (United States)

    Delnooz, Cathérine C S; Helmich, Rick C; Medendorp, W P; Van de Warrenburg, Bart P C; Toni, Ivan

    2013-03-01

    Simple writer's cramp (WC) is a task-specific form of dystonia, characterized by abnormal movements and postures of the hand during writing. It is extremely task-specific, since dystonic symptoms can occur when a patient uses a pencil for writing, but not when it is used for sharpening. Maladaptive plasticity, loss of inhibition, and abnormal sensory processing are important pathophysiological elements of WC. However, it remains unclear how those elements can account for its task-specificity. We used fMRI to isolate cerebral alterations associated with the task-specificity of simple WC. Subjects (13 simple WC patients, 20 matched controls) imagined grasping a pencil to either write with it or sharpen it. On each trial, we manipulated the pencil's position and the number of imagined movements, while monitoring variations in motor output with electromyography. We show that simple WC is characterized by abnormally increased activity in the dorsal premotor cortex (PMd) when imagined actions are specifically related to writing. This cerebral effect was independent from the known deficits in dystonia in generating focal motor output and in processing somatosensory feedback. This abnormal activity of the PMd suggests that the task-specific element of simple WC is primarily due to alterations at the planning level, in the computations that transform a desired action outcome into the motor commands leading to that action. These findings open the way for testing the therapeutic value of interventions that take into account the computational substrate of task-specificity in simple WC, e.g. modulations of PMd activity during the planning phase of writing.

  8. Organ-sparing treatment for primarily disseminated breast cancer with metachronous bilateral involvement

    Directory of Open Access Journals (Sweden)

    Yu. A. Ragulin

    2016-01-01

    Full Text Available Systemic drug therapy remains first-line treatment for primarily disseminated breast cancer (BC. The problem in the use of local methods to treat BC patients with distant metastases has not been fully solved. The most of investigations presented in the modern literature suggest that patients show significantly better survivals after adjuvant systemic therapy with local exposure of a primary tumor, the main goal of which is its local monitoring. At the same time, the choice of optimal treatments and their sequence and combination remain to be explored. The paper describes a case of successful organ-sparing chemoradiation therapy for primarily disseminated BC with metachronous bilateral involvement.

  9. Tractor Safety. Unit A-9.

    Science.gov (United States)

    Luft, Vernon D.; Backlund, Paul

    This document is a teacher's guide for a unit in tractor and machinery safety for college freshmen. It is intended to be used for 10 hours of instruction for freshmen who are intending to work on or around machinery. Safety hazards directly and indirectly related to many types of machinery are covered in addition to tractors. The objectives of the…

  10. Lamin A/C mutation affecting primarily the right side of the heart

    Directory of Open Access Journals (Sweden)

    Laura Ollila

    2013-04-01

    Full Text Available LMNA mutations are amongst the most important causes of familial dilated cardiomyopathy. The most important cause of arrhythmogenic right ventricular cardiomyopathy (ARVC is desmosomal pathology. The aim of the study was to elucidate the role of LMNA mutations among Finnish cardiomyopathy patients. We screened 135 unrelated cardiomyopathy patients for LMNA mutations. Because of unusual phenotype, two patients were screened for the known Finnish ARVC-related mutations of desmosomal genes, and their Plakophilin-2b gene was sequenced. Myocardial samples from two patients were examined by immunohistochemical plakoglobin staining and in one case by electron microscopy. We found a new LMNA mutation Phe237Ser in a family of five affected members with a cardiomyopathy affecting primarily the right side of the heart. The phenotype resembles ARVC but does not fulfill the Task Force Criteria. The main clinical manifestations of the mutation were severe tricuspid insufficiency, right ventricular enlargement and failure. Three of the affected patients died of the heart disease, and the two living patients received heart transplants at ages 44 and 47. Electron microscopy showed nuclear blebbing compatible with laminopathy. Immunohisto - chemical analysis did not suggest desmosomal pathology. No desmosomal mutations were found. The Phe237Ser LMNA mutation causes a phenotype different from traditional cardiolaminopathy. Our findings suggest that cardiomyopathy affecting primarily the right side of the heart is not always caused by desmosomal pathology. Our observations highlight the challenges in classifying cardiomyopathies, as there often is significant overlap between the traditional categories.

  11. Temporal integration of loudness in listeners with hearing losses of primarily cochlear origin

    DEFF Research Database (Denmark)

    Buus, Søren; Florentine, Mary; Poulsen, Torben

    1999-01-01

    To investigate how hearing loss of primarily cochlear origin affects the loudness of brief tones, loudness matches between 5- and 200-ms tones were obtained as a function of level for 15 listeners with cochlear impairments and for seven age-matched controls. Three frequencies, usually 0.5, 1, and 4......-frequency hearing losses (slopes >50 dB/octave) showed larger-than-normal maximal amounts of temporal integration (40 to 50 dB). This finding is consistent with the shallow loudness functions predicted by our excitation-pattern model for impaired listeners [, in Modeling Sensorineural Hearing Loss, edited by W....... Jesteadt (Erlbaum, Mahwah, NJ, 1997), pp. 187–198]. Loudness functions derived from impaired listeners' temporal-integration functions indicate that restoration of loudness in listeners with cochlear hearing loss usually will require the same gain whether the sound is short or long. ©1999 Acoustical...

  12. N170 Changes Show Identifiable Chinese Characters Compete Primarily with Faces Rather than Houses.

    Science.gov (United States)

    Fan, Cong; He, Weiqi; He, Huamin; Ren, Guofang; Luo, Yuejia; Li, Hong; Luo, Wenbo

    2015-01-01

    Character processing is a crucial cognitive skill that is highly emphasized and industriously cultivated in contemporary society. In the present study, using a competition paradigm, we examined the electrophysiological correlates of different relationships between Chinese characters and faces and between Chinese characters and houses during early visual processing. We observed that identifiable Chinese characters compete primarily with faces rather than houses at an early visual processing stage, with a significantly reduced N170 for faces but not for houses, when they were viewed concurrently with identifiable characters relative to when they were viewed concurrently with unidentifiable characters. Consistent with our previous study, there was a significant increase in N170 after characters have been learned, indicating a modulatory effect of Chinese character identification level on N170 amplitude. Furthermore, we found an enlarged N170 in response to faces compared to houses, indicating that the neural mechanisms for processing faces and houses are different at an early visual processing stage.

  13. Which sensory perception is primarily considered, in consumers’ hedonic evaluation of foods?

    DEFF Research Database (Denmark)

    Andersen, Barbara Vad; Brockhoff, Per B.; Hyldig, Grethe

    2015-01-01

    An analysis of the primary hedonic drivers of liking and sensory satisfaction will provide valuable information to product developers on which sensory properties to emphasise the most. The aims of the present study were: a) to study if liking of the sensory properties: appearance, odour, taste...... and texture were considered equally, when consumers rated overall liking and sensory satisfaction b) to study if the relation depended on, whether liking of sensory properties were related to overall liking or sensory satisfaction, and c) to study individual differences in which sensory properties...... the consumers primarily paid attention to when rating overall liking and sensory satisfaction, respectively. Four apple-cherry fruit drinks were used, varying in: type of sweetener, and addition of aroma and fibre. The fruit drinks were used in a in a cross-over consumer study on 67 subjects together...

  14. Non-Hodgkin's Lymphoma Primarily Presenting with Fanconi Syndrome and Acute Kidney Injury

    Institute of Scientific and Technical Information of China (English)

    Wen-ling Ye; Bing Han; Bing-yan Liu; Chan Meng; Wei Ye; Yu-bing Wen; Hang Li; Xue-mei Li

    2010-01-01

    @@ KIDNEY involvement is common in non-Hodg-kin's lymphoma (NHL) with incidence up to 30%-40% in autopsy studies. However, it us-ually occurs late in the course of the disease and is clinically silent. Clinically overt renal disease in-cluding acute kidney injury (AKI) as its primary manifes-tation is rarely reported, moreover, Fanconi syndrome (FS) is extremely rare as the main manifestation in NHL. In this report, we presented a case of NHL primarily presenting with FS and AKI due to diffuse interstitial infiltration of NHL cells and emphasized the important role of renal biopsy, especially renal immunohistochemical analysis in the di-agnosis of renal diffuse lymphoma.

  15. Consensus guidelines for oral dosing of primarily renally cleared medications in older adults.

    Science.gov (United States)

    Hanlon, Joseph T; Aspinall, Sherrie L; Semla, Todd P; Weisbord, Steven D; Fried, Linda F; Good, C Bernie; Fine, Michael J; Stone, Roslyn A; Pugh, Mary Jo V; Rossi, Michelle I; Handler, Steven M

    2009-02-01

    To establish consensus oral dosing guidelines for primarily renally cleared medications prescribed for older adults. Literature search followed by a two-round modified Delphi survey. A nationally representative survey of experts in geriatric clinical pharmacy. Eleven geriatric clinical pharmacists. After a comprehensive literature search and review by an investigative group of six physicians (2 general internal medicine, 2 nephrology, 2 geriatrics), 43 dosing recommendations for 30 medications at various levels of renal function were created. The expert panel rated its agreement with each of these 43 dosing recommendations using a 5-point Likert scale (1=strongly disagree to 5=strongly agree). Recommendation-specific means and 95% confidence intervals were estimated. Consensus was defined as a lower 95% confidence limit of greater than 4.0 for the recommendation-specific mean score. The response rate was 81.8% (9/11) for the first round. All respondents who completed the first round also completed the second round. The expert panel reached consensus on 26 recommendations involving 18 (60%) medications. For 10 medications (chlorpropamide, colchicine, cotrimoxazole, glyburide, meperidine, nitrofurantoin, probenecid, propoxyphene, spironolactone, and triamterene), the consensus recommendation was not to use the medication in older adults below a specified level of renal function (e.g., creatinine clearance <30 mL/min). For the remaining eight medications (acyclovir, amantadine, ciprofloxacin, gabapentin, memantine, ranitidine, rimantadine, and valacyclovir), specific recommendations for dose reduction or interval extension were made. An expert panel of geriatric clinical pharmacists was able to reach consensus agreement on a number of oral medications that are primarily renally cleared.

  16. Efficient transfection of DNA into primarily cultured rat sertoli cells by electroporation.

    Science.gov (United States)

    Li, Fuping; Yamaguchi, Kohei; Okada, Keisuke; Matsushita, Kei; Enatsu, Noritoshi; Chiba, Koji; Yue, Huanxun; Fujisawa, Masato

    2013-03-01

    The expression of exogenous DNA in Sertoli cells is essential for studying its functional genomics, pathway analysis, and medical applications. Electroporation is a valuable tool for nucleic acid delivery, even in primarily cultured cells, which are considered difficult to transfect. In this study, we developed an optimized protocol for electroporation-based transfection of Sertoli cells and compared its efficiency with conventional lipofection. Sertoli cells were transfected with pCMV-GFP plasmid by square-wave electroporation under different conditions. After transfection of plasmid into Sertoli cells, enhanced green fluorescent protein (EGFP) expression could be easily detected by fluorescent microscopy, and cell survival was evaluated by dye exclusion assay using Trypan blue. In terms of both cell survival and the percentage expressing EGFP, 250 V was determined to produce the greatest number of transiently transfected cells. Keeping the voltage constant (250 V), relatively high cell survival (76.5% ± 3.4%) and transfection efficiency (30.6% ± 5.6%) were observed with a pulse length of 20 μm. The number of pulses significantly affected cell survival and EGFP expression (P electroporation (21.5% ± 5.7%) was significantly higher than those of Lipofectamine 2000 (2.9% ± 1.0%) and Effectene (1.9% ± 0.8%) in this experiment (P electroporation conditions, and the successful electroporation of plasmid DNA into primarily cultured Sertoli cells. Our results indicate that the method of electroporation is more suitable than other approaches for the transfection of Sertoli cells.

  17. Planning Office and Community Influence on Land-Use Decisions Intended to Benefit the Low-Income: Welcome to Chicago

    Directory of Open Access Journals (Sweden)

    Yan Dominic Searcy

    2014-01-01

    Full Text Available This study explores urban planning office and community influence on land-use decision making in two poverty-stricken but redeveloping neighborhood areas in Chicago. The Department of Planning and Development in this study had marginal impact on land-use decisions due to administrative limitations. Community influence is moderated by the degree to which low-income housing advocates can act directly as developers and produce housing units. The research findings indicate that land-use decisions intended to benefit the low-income resulted not from community-based political conflict but more so from community organization cooperation with political actors.

  18. The development and characterization of a primarily mineral calcium phosphate - poly(epsilon-caprolactone) biocomposite

    Science.gov (United States)

    Dunkley, Ian Robert

    Orthopaedic reconstruction often involves the surgical introduction of structural implants that provide for rigid fixation, skeletal stabilization, and bone integration. The high stresses incurred by these implanted devices have historically limited material choices to metallic and select polymeric formulations. While mechanical requirements are achieved, these non-degradable materials do not participate actively in the remodeling of the skeleton and present the possibility of long-term failure or rejection. This is particularly relevant in cervical fusion, an orthopaedic procedure to treat damaged, degenerative or diseased intervertebral discs. A significant improvement on the available synthetic bone replacement/regeneration options for implants to treat these conditions in the cervical spine may be achieved with the development of primarily mineral biocomposites comprised of a bioactive ceramic matrix reinforced with a biodegradable polymer. Such a biocomposite may be engineered to possess the clinically required mechanical properties of a particular application, while maintaining the ability to be remodeled completely by the body. A biocomposite of Si-doped calcium phosphate (Si-CaP) and poly(epsilon-caprolactone) (PCL) was developed for application as such a synthetic bone material for potential use as a fusion device in the cervical spine. In this thesis, a method by which high mineral content Si-CaP/PCL biocomposites with interpenetrating matrices of mineral and polymer phases may be prepared will be demonstrated, in addition to the effects of the various preparation parameters on the biocomposite density, porosity and mechanical properties. This new technique by which dense, primarily ceramic Si-CaP/PCL biocomposites were prepared, allowed for the incorporation of mineral contents ranging between 45-97vol%. Polymer infiltration, accomplished solely by passive capillary uptake over several days, was found to be capable of fully infiltrating the microporosity

  19. Fungi and Mycotoxins in Feed Intended for Sows at Different Reproductive Stages in Argentina

    Directory of Open Access Journals (Sweden)

    Carina Maricel Pereyra

    2010-01-01

    Full Text Available The aim of this study was to evaluate fungi and contamination levels of aflatoxin B1, ochratoxin A, fumonisin B1, and zearalenone in raw materials and finished feed intended for sows at different reproductive stages. Total fungi, Aspergillus, Penicillium, and Fusarium species occurrence, were examined. Aspergillus flavus, A. niger aggregate spp., and F. verticillioides were the prevalent species. Fungal counts exceeded the levels proposed as feed hygienic quality limits (1×104 colony forming units at all reproductive stages. Aflatoxin B1, ochratoxin A, fumonisin B1, and zearalenone were detected by high-pressure liquid chromatography. Aflatoxin levels in 80% samples of finished sow feeds were over the permitted levels of 0.02 μg g-1 (mean 228.2±95 μg Kg−1. Fumonisin B1 was detected in all tested raw materials at levels that varied from 50.3 to 1137.64 μg Kg−1 and finished feed samples at levels that ranged from 99.8 to 512.4 μg Kg−1. Aflatoxin B1, zearalenone, and ochratoxin A were not detected in raw materials. All finished feeds were negative for zearalenone contamination whereas all nonpregnant gilt samples were contaminated with low OTA levels (mean 0.259±0.123. This fact requires periodic monitoring to prevent the occurrence of mycotoxicosis in animal production, to reduce the economic losses, and to minimize hazards to human health.

  20. Genotoxicity of styrene oligomers extracted from polystyrene intended for use in contact with food

    Directory of Open Access Journals (Sweden)

    Makoto Nakai

    2014-01-01

    Full Text Available Here, we conducted in vitro genotoxicity tests to evaluate the genotoxicity of styrene oligomers extracted from polystyrene intended for use in contact with food. Styrene oligomers were extracted with acetone and the extract was subjected to the Ames test (OECD test guideline No. 471 and the in vitro chromosomal aberration test (OECD test guideline No. 473 under good laboratory practice conditions. The concentrations of styrene dimers and trimers in the concentrated extract were 540 and 13,431 ppm, respectively. Extraction with acetone provided markedly higher concentrations of styrene oligomers compared with extraction with 50% ethanol aqueous solution, which is the food simulant currently recommended for use in safety assessments of polystyrene by both the United States Food and Drug Administration and the European Food Safety Authority. And these high concentrations of styrene dimers and trimers were utilized for the evaluation of genotoxicity in vitro. Ames tests using five bacterial tester strains were negative both in the presence or absence of metabolic activation. The in vitro chromosomal aberration test using Chinese hamster lung cells (CHL/IU was also negative. Together, these results suggest that the risk of the genotoxicity of styrene oligomers that migrate from polystyrene food packaging into food is very low.

  1. Notionally steady background noise acts primarily as a modulation masker of speech.

    Science.gov (United States)

    Stone, Michael A; Füllgrabe, Christian; Moore, Brian C J

    2012-07-01

    Stone et al. [J. Acoust. Soc Am. 130, 2874-2881 (2011)], using vocoder processing, showed that the envelope modulations of a notionally steady noise were more effective than the envelope energy as a masker of speech. Here the same effect is demonstrated using non-vocoded signals. Speech was filtered into 28 channels. A masker centered on each channel was added to the channel signal at a target-to-background ratio of -5 or -10 dB. Maskers were sinusoids or noise bands with bandwidth 1/3 or 1 ERB(N) (ERB(N) being the bandwidth of "normal" auditory filters), synthesized with Gaussian (GN) or low-noise (LNN) statistics. To minimize peripheral interactions between maskers, odd-numbered channels were presented to one ear and even to the other. Speech intelligibility was assessed in the presence of each "steady" masker and that masker 100% sinusoidally amplitude modulated (SAM) at 8 Hz. Intelligibility decreased with increasing envelope fluctuation of the maskers. Masking release, the difference in intelligibility between the SAM and its "steady" counterpart, increased with bandwidth from near-zero to around 50 percentage points for the 1-ERB(N) GN. It is concluded that the sinusoidal and GN maskers behaved primarily as energetic and modulation maskers, respectively.

  2. Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex

    Science.gov (United States)

    Teleńczuk, Bartosz; Dehghani, Nima; Le Van Quyen, Michel; Cash, Sydney S.; Halgren, Eric; Hatsopoulos, Nicholas G.; Destexhe, Alain

    2017-01-01

    The local field potential (LFP) is generated by large populations of neurons, but unitary contribution of spiking neurons to LFP is not well characterised. We investigated this contribution in multi-electrode array recordings from human and monkey neocortex by examining the spike-triggered LFP average (st-LFP). The resulting st-LFPs were dominated by broad spatio-temporal components due to ongoing activity, synaptic inputs and recurrent connectivity. To reduce the spatial reach of the st-LFP and observe the local field related to a single spike we applied a spatial filter, whose weights were adapted to the covariance of ongoing LFP. The filtered st-LFPs were limited to the perimeter of 800 μm around the neuron, and propagated at axonal speed, which is consistent with their unitary nature. In addition, we discriminated between putative inhibitory and excitatory neurons and found that the inhibitory st-LFP peaked at shorter latencies, consistently with previous findings in hippocampal slices. Thus, in human and monkey neocortex, the LFP reflects primarily inhibitory neuron activity. PMID:28074856

  3. Floral biology of two Vanilloideae (Orchidaceae) primarily adapted to pollination by euglossine bees.

    Science.gov (United States)

    Pansarin, E R; Pansarin, L M

    2014-11-01

    Vanilloideae comprises 15 genera distributed worldwide, among which are Vanilla and Epistephium (tribe Vanilleae). Based on field and laboratory investigations, the pollination biology of V. dubia and E. sclerophyllum was analysed. The former was surveyed in a semi-deciduous mesophytic forest at the biological reserve of Serra do Japi and in a marshy forest at the city of Pradópolis, southeastern Brazil. The latter was examined in rocky outcrop vegetation in the Chapada Diamantina, northeastern Brazil. In the studied populations, the tubular flowers of V. dubia and E. sclerophyllum were pollinated by bees. Pollen was deposited on either their scutellum (V. dubia) or scutum (E. sclerophyllum). The mentum region of V. dubia is dry, whereas that of E. sclerophyllum presents a small quantity of dilute nectar. Flowers of E. sclerophyllum are scentless, while those of V. dubia are odoriferous. Although V. dubia is self-compatible, it needs a pollinator to produce fruit. In contrast, E. sclerophyllum sets fruit through spontaneous self-pollination, but biotic pollination also occurs. Both species are primarily adapted to pollination by euglossine bees. Pollination by Euglossina seems to have occurred at least twice during the evolution of Vanilleae. Furthermore, shifts between rewarding and reward-free flowers and between autogamous and allogamous species have been reported among vanillas. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  4. Hepatitis B virus infection and replication in primarily cultured human fetal hepatocytes

    Institute of Scientific and Technical Information of China (English)

    Min Lin; Qun Chen; Li-Ye Yang; Wen-Yu Li; Xi-Biao Cao; Jiao-Ren Wu; You-Peng Peng; Mo-Rui Chen

    2007-01-01

    AIM:To investigate the infection and replication of hepatitis B virus(HBV)in primarily cultured human fetal hepatocytes(HFHs).METHODS:The human fetal hepatocytes were cultured in serum-free medium,HBV-positive serum was added into the medium to study the susceptibility of hepatocytes to HBV infection.The supernatant was collected for ELISA assay of HBsAg and HBeAg,and quantitative fluorescence PCR for HBV-DNA assay daily.Albumin and HBcAg,CK8 and CK18 expressions were detected by immunohistochemistry in cultured hepatocytes.Content of lactate dehydrogenate(LDH)was measured to find out the integrity of the cell membrane.RESULTS:A stable hepatocyte culture system was established.HBV could infect the hepatocytes and replicate,and HBcAg expression could be detected by immunohistochemistry in hepatocyte-like cells.HBV-DNA in the supernatant could be detected from d 2 to d 18 and HBsAg and HBeAg were positive on d 3-d 18 after HBV infection.HBV in medium increased from d 0 to d 6 and subsequently decreased as the cells were progressively loosing their hepatocyte phenotypes.CONCLUSION:HBV could infect human fetal hepatocytes and replicate.This in vitro model allowed a detailed Study on early events associated with human HBV entry into cells and subsequent replication.

  5. Audiovisual contrast enhancement is articulated primarily via the M-pathway.

    Science.gov (United States)

    Jaekl, Philip M; Soto-Faraco, Salvador

    2010-12-17

    Although it has been previously reported that audiovisual integration can modulate performance on some visual tasks, multisensory interactions have not been explicitly assessed in the context of different visual processing pathways. In the present study, we test auditory influences on visual processing employing a psychophysical paradigm that reveals distinct spatial contrast signatures of magnocellular and parvocellular visual pathways. We found that contrast thresholds are reduced when noninformative sounds are presented with transient, low-frequency Gabor patch stimuli and thus favor the M-system. In contrast, visual thresholds are unaffected by concurrent sounds when detection is primarily attributed to P-pathway processing. These results demonstrate that the visual detection enhancement resulting from multisensory integration is mainly articulated by the magnocellular system, which is most sensitive at low spatial frequencies. Such enhancement may subserve stimulus-driven processes including the orientation of spatial attention and fast, automatic ocular and motor responses. This dissociation helps explain discrepancies between the results of previous studies investigating visual enhancement by sounds.

  6. Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertained?

    Science.gov (United States)

    Teschke, Rolf; Frenzel, Christian; Schulze, Johannes; Eickhoff, Axel

    2012-06-01

    Spontaneous reports of primarily assumed hepatotoxicity in connection with the use of Pelargonium sidoides (PS) have been interpreted by the Drug Commission of the German Medical Association (DCGMA) as showing some hepatotoxic potential of PS used to treat common cold and other respiratory tract infections. Causality for PS was assessed using the liver specific, structured, quantitative, and updated scale of the Council for International Organizations of Medical Sciences (CIOMS). In none of the 15 cases was there a highly probable or probable causality for PS. Analysis revealed confounding factors such as numerous final diagnoses unrelated to PS and poor data quality in virtually all cases. In only a minority of the cases were data provided to consider even common other diseases of the liver. For instance, biliary tract imaging data were available in only 3 patients; data to exclude virus infections by hepatitis A-C were provided in 4 cases and by CMV and EBV in 1 case, whereas HSV and VZV virus infections remained unconsidered. Thus, convincing evidence is lacking that PS was a potential hepatotoxin in the analyzed cases.

  7. Job Satisfaction, Retirement Attitude and Intended Retirement Age: A Conditional Process Analysis across Workers’ Level of Household Income

    Science.gov (United States)

    Davies, Eleanor M. M.; Van der Heijden, Beatrice I. J. M.; Flynn, Matt

    2017-01-01

    In the contemporary workplace, insight into retirement behaviors is of crucial importance. Previous empirical evidence has found mixed results regarding the relationship between work attitudes, such as job satisfaction, and retirement behaviors, suggesting that further scholarly examination incorporating moderating and mediating variables into retirement models is needed. Drawing on comparative models of attitude to retirement, we hypothesized a direct relationship between job satisfaction and intended retirement age for workers with a high household income and an indirect relationship between job satisfaction and intended retirement age, via retirement attitude, for workers with a low or mean household income. We collected data from a sample of 590 United Kingdom workers aged 50+. Using conditional process analysis, we found that the underlying mechanisms in our research model differ according to socio-economic status. We found no direct effect between job satisfaction and intended retirement age. However, an indirect effect was observed between job satisfaction and intended retirement age, via retirement attitude, for both low- and mean-household income individuals. Specifically, the relationship between job satisfaction and retirement attitude differed according to socio-economic group: for high-household income older workers, there was no relationship between job satisfaction and retirement attitude. However, for low- and mean-household income older workers, we observed a negative relationship between job satisfaction and retirement attitude. Otherwise stated, increases in job satisfaction for mean and low household income workers are likely to make the prospect of retirement less attractive. Therefore, we argue that utmost care must be taken around the conditions under which lower income employees will continue their work when getting older in order to protect their sustainable employability. PMID:28620329

  8. Intending Projects

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Project name: 90,000t/a BR device and auxiliary projects Construction unit: Sinopec Beijing Yanshan Petrochemical Company Total investment: 2.257 billion yuan Project description: It will cover an area of 14. lha.

  9. Investigation of Social Studies Teachers' Intended Uses of Social Networks in Terms of Various Variables

    Science.gov (United States)

    Akgün, Ismail Hakan

    2016-01-01

    The aim of this research is to determine Social Studies teacher candidates' intended uses of social networks in terms of various variables. The research was carried out by using screening model of quantitative research methods. In the study, "The Social Network Intended Use Scale" was used as a data collection tool. As a result of the…

  10. Physical Medicine Devices; Reclassification of Iontophoresis Device Intended for Any Other Purposes. Final order.

    Science.gov (United States)

    2016-07-26

    The Food and Drug Administration (FDA) is issuing a final order to reclassify iontophoresis devices intended for any other purposes, which are preamendments class III devices (regulated under product code EGJ), into class II (special controls) and to amend the device identification to clarify that devices intended to deliver specific drugs are not considered part of this regulatory classification.

  11. Intended motion estimation using fuzzy Kalman filtering for UAV image stabilization with large drifting

    Science.gov (United States)

    Xin, Tiantian; Zhao, Hongying; Liu, Sijie; Wang, Lu

    2015-03-01

    Videos from a small Unmanned Aerial Vehicle (UAV) are always unstable because of the wobble of the vehicle and the impact of surroundings, especially when the motion has a large drifting. Electronic image stabilization aims at removing the unwanted wobble and obtaining the stable video. Then estimation of intended motion, which represents the tendency of global motion, becomes the key to image stabilization. It is usually impossible for general methods of intended motion estimation to obtain stable intended motion remaining as much information of video images and getting a path as much close to the real flying path at the same time. This paper proposed a fuzzy Kalman filtering method to estimate the intended motion to solve these problems. Comparing with traditional methods, the fuzzy Kalman filtering method can achieve better effect to estimate the intended motion.

  12. 78 FR 66840 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

    Science.gov (United States)

    2013-11-07

    ... Guns and Toy Guns Not Intended for Use With Caps AGENCY: Consumer Product Safety Commission. ACTION...-producing toys. Existing CPSC regulations pertaining to caps intended for use with toy guns refer to... intended for use with toy guns and toy guns not intended for use with caps. The final rule is...

  13. National Security: An Overview of Professional Development Activities Intended to Improve Interagency Collaboration

    Science.gov (United States)

    2010-11-01

    professional development activities could help bridge those gaps. GAO was asked to identify: (1) training and other professional development activities intended to improve the ability of key national security agencies’ personnel to collaborate across organizational lines and (2) how these activities were intended to improve participants’ collaboration abilities. To address these objectives, GAO asked nine key agencies involved in national security issues to submit information on professional development activities that

  14. Intended And Unintended Effects Of The War On Poverty: What Research Tells Us And Implications For Policy.

    Science.gov (United States)

    Bitler, Marianne P; Karoly, Lynn A

    2015-01-01

    During the mid-1960s, the United States adopted a series of cash and in-kind transfer programs, as well as human capital investment strategies, as part of the War on Poverty. A number of other programs were first proposed as part of this "war" but were not implemented until the mid-1970s. These programs had noble goals: to increase incomes at the bottom of the income distribution, reduce poverty, and improve nutrition, heath, and human capital. However, various features of the programs also had the potential to produce unintended consequences: for example, means-tested programs can discourage work. In this paper, we comprehensively evaluate the main War on Poverty programs that were aimed at the low-income nonelderly population along with several follow-on programs. We focus on both intended and unintended consequences, drawing on the most compelling causal evidence. We conclude with a series of lessons learned and questions that are outstanding.

  15. Human motor unit recordings: origins and insight into the integrated motor system.

    Science.gov (United States)

    Duchateau, Jacques; Enoka, Roger M

    2011-08-29

    Soon after Edward Liddell [1895-1981] and Charles Sherrington [1857-1952] introduced the concept of a motor unit in 1925 and the necessary technology was developed, the recording of single motor unit activity became feasible in humans. It was quickly discovered by Edgar Adrian [1889-1977] and Detlev Bronk [1897-1975] that the force exerted by muscle during voluntary contractions was the result of the concurrent recruitment of motor units and modulation of the rate at which they discharged action potentials. Subsequent studies found that the relation between discharge frequency and motor unit force was characterized by a sigmoidal function. Based on observations on experimental animals, Elwood Henneman [1915-1996] proposed a "size principle" in 1957 and most studies in humans focussed on validating this concept during various types of muscle contractions. By the end of the 20th C, the experimental evidence indicated that the recruitment order of human motor units was determined primarily by motoneuron size and that the occasional changes in recruitment order were not an intended strategy of the central nervous system. Fundamental knowledge on the function of Sherrington's "common final pathway" was expanded with observations on motor unit rotation, minimal and maximal discharge rates, discharge variability, and self-sustained firing. Despite the great amount of work on characterizing motor unit activity during the first century of inquiry, however, many basic questions remain unanswered and these limit the extent to which findings on humans and experimental animals can be integrated and generalized to all movements.

  16. Demonstration lessons in mathematics education: teachers' observation foci and intended changes in practice

    Science.gov (United States)

    Clarke, Doug; Roche, Anne; Wilkie, Karina; Wright, Vince; Brown, Jill; Downton, Ann; Horne, Marj; Knight, Rose; McDonough, Andrea; Sexton, Matthew; Worrall, Chris

    2013-06-01

    As part of a teacher professional learning project in mathematics education, university mathematics educators taught demonstration lessons in project primary schools. These lessons were part of a "pre-brief, teaching, and debrief" process, in which up to eight teachers observed each lesson. Using brief questionnaires completed in advance of the lesson, during the lesson, following the debrief, and several weeks later, data were collected on teachers' intended and actual observation foci and any anticipated changes in their beliefs and practices arising from the experience. There were several common themes in teachers' intended observations, including a focus on questioning, catering for individual differences, and building student engagement. As evident in other research, teachers' intended and actual observations gave greater attention to teacher actions and decision making than to student learning and thinking. In this paper, we situate demonstration lessons within teacher professional learning models, describe the features of our model, summarise teacher data, and discuss issues arising from our work.

  17. Prognostic cell biological markers in cervical cancer patients primarily treated with (chemo)radiation : a systematic review

    NARCIS (Netherlands)

    Noordhuis, Maartje G; Eijsink, Jasper J H; Roossink, Frank; de Graeff, Pauline; Pras, Elisabeth; Schuuring, Ed; Wisman, G Bea A; de Bock, Geertruida H; van der Zee, Ate G J

    2011-01-01

    The aim of this study was to systematically review the prognostic and predictive significance of cell biological markers in cervical cancer patients primarily treated with (chemo)radiation. A PubMed, Embase, and Cochrane literature search was performed. Studies describing a relation between a cell b

  18. Ruptured episiotomia resutured primarily.

    Science.gov (United States)

    Monberg, J; Hammen, S

    1987-01-01

    In a randomized study, 35 patients with ruptured episiotomy were treated in two ways. One group, treated with Clindamycin and primary resuture, did better than the other group, not resutured but spontaneously healed.

  19. 49 CFR 178.275 - Specification for UN Portable Tanks intended for the transportation of liquid and solid hazardous...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification for UN Portable Tanks intended for... Portable Tanks § 178.275 Specification for UN Portable Tanks intended for the transportation of liquid and... definitions and requirements that apply to UN portable tanks intended for the transportation of liquid...

  20. 77 FR 37834 - Revocation of Certain Requirements Pertaining to Caps Intended for Use With Toy Guns and Toy Guns...

    Science.gov (United States)

    2012-06-25

    ... Guns and Toy Guns Not Intended for Use With Caps AGENCY: Consumer Product Safety Commission. ACTION... use with toy guns and toy guns not intended for use with caps, which were included in the regulations... revoke our existing banning regulations pertaining to caps intended for use with toy guns and toy...

  1. 34 CFR 386.34 - What assurances must be provided by a grantee that intends to provide scholarships?

    Science.gov (United States)

    2010-07-01

    ... intends to provide scholarships? 386.34 Section 386.34 Education Regulations of the Offices of the... Award? § 386.34 What assurances must be provided by a grantee that intends to provide scholarships? A grantee under this part that intends to grant scholarships for any academic year beginning after June...

  2. 21 CFR 328.50 - Principal display panel of all OTC drug products intended for oral ingestion that contain alcohol.

    Science.gov (United States)

    2010-04-01

    ... intended for oral ingestion that contain alcohol. 328.50 Section 328.50 Food and Drugs FOOD AND DRUG... PRODUCTS INTENDED FOR ORAL INGESTION THAT CONTAIN ALCOHOL Labeling § 328.50 Principal display panel of all OTC drug products intended for oral ingestion that contain alcohol. (a) The amount (percentage) of...

  3. 21 CFR 310.103 - New drug substances intended for hypersensitivity testing.

    Science.gov (United States)

    2010-04-01

    ... testing. 310.103 Section 310.103 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... § 310.103 New drug substances intended for hypersensitivity testing. (a) The Food and Drug... testing is not promoted by the manufacturer or distributor. (2) The new drug substance requested is an...

  4. Recent and intended drug trafficking among male and female urban African-American early adolescents.

    Science.gov (United States)

    Li, X; Feigelman, S

    1994-06-01

    To investigate associations between recent and intended involvement in drug trafficking and perceptions of the social environment among high-risk urban African-American youths. A multicomponent risk assessment survey was conducted among a convenience sample of 351 African-American youths 9 through 15 years of age residing in low-income communities. Both univariate analysis and logistic regression were performed to examine the association of youths' perceived social environment with recent and intended involvement in drug trafficking. Drug selling or delivering in the previous 6 months was reported by 6% of the youths; 12% expected to engage in these activities in the next 6 months. There was a strong association between drug trafficking and other high-risk behaviors, including drug use. Among both genders, perceptions that neighbors, friends, or family members were involved in drug trafficking were correlated with recent or intended drug trafficking. For boys, personal economic needs had a strong association with drug trafficking. For girls, personal feelings were more important correlates of intended involvement. Efforts aimed at both drug-trafficking prevention and intervention need to be community-based and multifaceted. Programs should address the youths' perceived social environments and consider gender differences regarding correlates of drug-trafficking involvement.

  5. Medications not intended for treatment of dyslipidemias and with a variable effect on lipids.

    Science.gov (United States)

    Whayne, Thomas F; Mukherjee, Debabrata

    2014-01-01

    Many therapeutically active medications have significant side effects, some of which can compromise the intended therapeutic goal. The development of plasma lipid abnormalities or a dyslipidemia as the result of a medication intended for an unrelated effect has been reported. Human immunodeficiency virus (HIV) infection can cause dyslipidemia as can the medications used to treat this infection. Such dyslipidemia can be a significant problem made more relevant by the already increased risk of cardiovascular (CV) disease faced by these patients. Some hypoglycemic medications used to treat diabetes can also be associated with dyslipidemia, most notably rosiglitazone. Antihypertensive medications are intended to decrease CV risk but are not free of dyslipidemia problems with thiazides able to cause hypertriglyceridemia and older beta-blockers without an alpha-blocking effect associated with moderate plasma lipid abnormalities and altered glucose metabolism. Estrogen administered orally can be associated with a severe hypertriglyceridemia. Currently-used antipsychotic medications have a significant association with hypertriglyceridemia. Clinicians must be aware of the dyslipidemias caused by these medications and know how to manage them, even treating a secondary dyslipidemia with another medication as in the case of HIV infection rather than trying to switch treatment of the infection in many cases. Mention is also made of lipid lowering effects of medications intended for other purposes (e.g. angiotensin receptor blockers and orlistat).

  6. The Designing Mind: Children's Reasoning about Intended Function and Artifact Structure

    Science.gov (United States)

    Kelemen, Deborah; Seston, Rebecca; Saint Georges, Laure

    2012-01-01

    There is currently debate about the emergence of children's ability to reason about artifacts by reference to their intended design. We present two studies demonstrating that, while 3-year-olds have emerging insights, 4-year-old children display an explicit, well-rounded, adult-like understanding of the way design constrains an artifact's physical…

  7. 21 CFR 201.310 - Phenindione; labeling of drug preparations intended for use by man.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Phenindione; labeling of drug preparations intended for use by man. 201.310 Section 201.310 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.310...

  8. 21 CFR 201.306 - Potassium salt preparations intended for oral ingestion by man.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Potassium salt preparations intended for oral ingestion by man. 201.306 Section 201.306 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.306 Potassium...

  9. Examination of Mathematics Intended Curriculum in China from an International Perspective

    Science.gov (United States)

    Wang, Yehui; Bian, Yufang; Xin, Tao; Kher, Neelam; Houang, Richard T.; Schmidt, William H.

    2012-01-01

    This study aimed to examine and track the transformations in the mathematics intended curriculum during the latest reform in China from a neutral and objective perspective. Following the document analysis used in TIMSS (the Third International Mathematics and Science Study), the results indicated that a more modern system of mathematics knowledge…

  10. Prognostic significance of clusterin expression in advanced-stage cervical cancer treated with curative intended radiotherapy.

    Science.gov (United States)

    Watari, Hidemichi; Kinoshita, Rumiko; Han, Yimin; Wang, Lei; Hosaka, Masayoshi; Taguchi, Hiroshi; Tsuchiya, Kazuhiko; Tanaka, Shinya; Shirato, Hiroki; Sakuragi, Noriaki

    2012-03-01

    Overexpression of clusterin (CLU), an antiapoptotic molecule, has been reported to induce resistance to radiotherapy (RT) in a variety of cancer cell types. The aim of this study was to evaluate the significance of CLU expression to predict survival of patients with advanced-stage cervical cancer who received curative intended RT. Biopsy tissue specimens of advanced-stage cervical cancer before curative intended RT were obtained from 34 patients who were treated at Hokkaido University Hospital between 1998 and 2008 and whose complete medical records were available. The expression of CLU protein was analyzed by immunohistochemistry. Findings were evaluated in relation to several clinicopathological factors. Survival analyses were performed using the Kaplan-Meier curves and the log-rank test. Independent prognostic factors were determined by multivariate Cox regression analysis. Clusterin protein was mainly present in the cytoplasm of cervical cancer cells. The expression of CLU protein in cervical cancer tissues before curative intended RT was not significantly related to any clinicopathological factors analyzed, including age, clinical stage, histologic type, and response to RT. Univariate analysis on prognostic factors showed that histologic type (P = 0.001), and CLU expression (P = 0.02) were related to survival. Multivariate analysis revealed that both histologic type (P = 0.002), and CLU expression (P = 0.02) were independent prognostic factors for overall survival. We conclude that CLU could be a new molecular marker to predict overall survival of patients with advanced-stage cervical cancer treated with curative intended RT.

  11. The Unintended Consequences of Intended Pregnancies: Youth, Condom Use, and HIV Transmission in Mozambique

    Science.gov (United States)

    Speizer, Ilene S.; White, Justin S.

    2008-01-01

    Although unwanted pregnancies can cause social and economic problems for Sub-Saharan African youth, the consequences of "intended" adolescent pregnancies have gone unnoticed. Rarely do studies recognize that youth who desire a pregnancy are less likely to practice safe sex and, therefore, are at greater risk of contracting sexually…

  12. Conceptual Integration of Hybridization by Algerian Students Intending to Teach Physical Sciences

    Science.gov (United States)

    Salah, Hazzi; Dumon, Alain

    2011-01-01

    This work aims to assess the difficulties encountered by students of the Ecole Normale Superieure of Kouba (Algeria) intending to teach physical science in the integration of the hybridization of atomic orbitals. It is a concept that they should use in describing the formation of molecular orbitals ([sigma] and [pi]) in organic chemistry and gaps…

  13. The Acquisition of Stereochemical Knowledge by Algerian Students Intending to Teach Physical Sciences

    Science.gov (United States)

    Boukhechem, Mohamed-Salah; Dumon, Alain; Zouikri, Mohamed

    2011-01-01

    In this work we evaluated the level of difficulty found in learning stereochemistry concepts, by students intending to teach physical sciences at the Ecole Normale Superieure (ENS) Kouba (Algeria). A paper and pencil questionnaire was administered to 170 students to evaluate: their familiarity with Newman representations; their ability of linking…

  14. A Conceptualization of Intended Learning Outcomes Supporting Self-Regulated Learners in Indicating Learning Paths

    Science.gov (United States)

    Tangworakitthaworn, P.; Gilbert, L.; Wills, G.B.

    2015-01-01

    Intended learning outcomes (ILOs) indicate what learners will be able to achieve after they are taught. Traditionally, ILOs are expressed as plain text or unstructured documents. What if all ILOs of a specific course of study can be conceptualized through a structured diagrammatic technique? It was hypothesized that learners can benefit from this…

  15. Conceptual Integration of Hybridization by Algerian Students Intending to Teach Physical Sciences

    Science.gov (United States)

    Salah, Hazzi; Dumon, Alain

    2011-01-01

    This work aims to assess the difficulties encountered by students of the Ecole Normale Superieure of Kouba (Algeria) intending to teach physical science in the integration of the hybridization of atomic orbitals. It is a concept that they should use in describing the formation of molecular orbitals ([sigma] and [pi]) in organic chemistry and gaps…

  16. Assessing Students' Opportunity to Learn the Intended Curriculum Using an Online Teacher Log: Initial Validity Evidence

    Science.gov (United States)

    Kurz, Alexander; Elliott, Stephen N.; Kettler, Ryan J.; Yel, Nedim

    2014-01-01

    This study provides initial evidence supporting intended score interpretations for the purpose of assessing opportunity to learn (OTL) via an online teacher log. MyiLOGS yields 5 scores related to instructional time, content, and quality. Based on data from 46 middle school classes, the evidence indicated that (a) MyiLOGS has high usability, (b)…

  17. The Unintended Consequences of Intended Pregnancies: Youth, Condom Use, and HIV Transmission in Mozambique

    Science.gov (United States)

    Speizer, Ilene S.; White, Justin S.

    2008-01-01

    Although unwanted pregnancies can cause social and economic problems for Sub-Saharan African youth, the consequences of "intended" adolescent pregnancies have gone unnoticed. Rarely do studies recognize that youth who desire a pregnancy are less likely to practice safe sex and, therefore, are at greater risk of contracting sexually…

  18. Assessing the operational life of flexible printed boards intended for continuous flexing applications : a case study.

    Energy Technology Data Exchange (ETDEWEB)

    Beck, David Franklin

    2011-01-01

    Through the vehicle of a case study, this paper describes in detail how the guidance found in the suite of IPC (Association Connecting Electronics Industries) publications can be applied to develop a high level of design assurance that flexible printed boards intended for continuous flexing applications will satisfy specified lifetime requirements.

  19. Managing the Risks of Food Intended for Consumption by Religious Consumers

    NARCIS (Netherlands)

    Rijn, Van I.; Vintila, Iuliana; Regenstein, Joe M.

    2016-01-01

    Since the production of food intended for consumption by religious consumers has increased, the need for clarity about the religious requirements and the risks involved is increasing. Some of these religious requirements find their origin in hygenic and/or food safety measures related to an adverse

  20. 30 CFR 75.1907 - Diesel-powered equipment intended for use in underground coal mines.

    Science.gov (United States)

    2010-07-01

    ... underground coal mines. 75.1907 Section 75.1907 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Diesel-Powered Equipment § 75.1907 Diesel-powered equipment intended for use in underground coal mines. (a) As...

  1. Biopharmaceuticals for rheumatic diseases in Latin America, Europe, Russia, and India: innovators, biosimilars, and intended copies.

    Science.gov (United States)

    Castañeda-Hernández, Gilberto; Szekanecz, Zoltan; Mysler, Eduardo; Azevedo, Valderilio F; Guzman, Renato; Gutierrez, Miguel; Rodríguez, Wilfredo; Karateev, Dmitry

    2014-12-01

    A biosimilar is a biopharmaceutical product intended to be comparable to a previously licensed biopharmaceutical agent. The goal of such products is to increase the accessibility of biopharmaceutical therapy for rheumatoid arthritis by reducing costs. They are not like generic drugs, in that they may differ from the reference products in manufacturing, composition, and formulation. Regulatory authorities strive to ensure the absence of clinically meaningful differences between biosimilars and their reference drugs. However, small molecular differences may potentially affect pharmacodynamics (including affinity), pharmacokinetics, and immunogenicity. Intended copies are non-innovator biopharmaceutical products that, unlike biosimilars, do not have enough clinical evidence to demonstrate biosimilarity. For approval of a biosimilar, most countries require preclinical and clinical studies demonstrating comparability with the reference drug. The margin for determining equivalence or non-inferiority is determined on a case-by-case basis in each country, as there are no general criteria. The European Medicines Agency and US Food and Drug Administration have stringent regulatory processes to ensure comparability of biosimilars with their reference drugs. There are also post-marketing surveillance requirements to monitor safety. Only one biosimilar, CT-P13, has been approved for rheumatoid arthritis. However, in countries with less stringent regulation, intended copies are being commercialized and safety problems have been documented. Consequently, in such countries, there is an urgent need for appropriate regulatory processes to be established. Attempts to close the affordability gap of biopharmaceuticals should not open another gap between patients treated with an innovator drug and an intended copy.

  2. The Policy Delphi: A Method for Identifying Intended and Unintended Consequences of Educational Policy

    Science.gov (United States)

    Manley, R. Adam

    2013-01-01

    This article highlights a rarely utilized but effective technique for identifying intended and unintended consequences of past or current policy or policy change. The author guides the reader through the process of identifying potential participants, contacting participants, developing the policy Delphi instrument, and analyzing the findings by…

  3. Was It Designed to Do That? Children's Focus on Intended Function in Their Conceptualization of Artifacts

    Science.gov (United States)

    Asher, Yvonne M.; Kemler Nelson, Deborah G.

    2008-01-01

    Do young children who seek the conceptual kind of an artifact weigh the plausibility that a current function constitutes the function intended by the object designer? Three- and four-year-olds were encouraged to question adults about novel artifacts. After inquiring about what an object was, some children were shown a function that plausibly…

  4. ANTIMICROBIAL REAGENTS AS FUNCTIONAL FINISHING FOR TEXTILES INTENDED FOR BIOMEDICAL APPLICATIONS. I. SYNTHETIC ORGANIC COMPOUNDS

    Directory of Open Access Journals (Sweden)

    Madalina Zanoaga

    2014-06-01

    Full Text Available This article offers an overview of some contemporary antimicrobial (biocides and biostatics agents used as functional finishing for textiles intended for biomedical applications. It reviews only synthetic agents, namely quaternary ammonium compounds, halogenated phenols, polybiguanides, N-halamines, and renewable peroxides, as a part of an extensive study currently in progress.

  5. Long-term intended and unintended experiences after Advanced Life Support training

    DEFF Research Database (Denmark)

    Rasmussen, M.B.; Dieckmann, Peter; Issenberg, Berry

    2012-01-01

    Highly structured simulation-based training (SBT) on managing emergency situations can have a significant effect on immediate satisfaction and learning. However, there are some indications of problems when applying learned skills to practice. The aim of this study was to identify long-term intend...... and unintended learner reactions, experiences and reflections after attending a simulation based Advanced Life Support (ALS) course....

  6. Virginia Teacher Licensure Examination Policy: Intended and Unintended Effects on Teacher Availability and Minority Representation

    OpenAIRE

    Grimes-Crump, Ruth H.

    2000-01-01

    VIRGINIA TEACHER LICENSURE EXAMINATION POLICY: INTENDED AND UNINTENDED EFFECTS ON TEACHER AVAILABILITY AND MINORITY REPRESENTATION Ruth H.Grimes-Crump (ABSTRACT) A major component of the screening process for prospective teachers is the licensure examination. The examination serves two important functions: (a) sorting and screening candidates and (b) defining the knowledge base for professional ...

  7. On the intended and unintended consequences of enhanced U.S. Border and interior immigration enforcement: evidence from Mexican deportees.

    Science.gov (United States)

    Amuedo-Dorantes, Catalina; Pozo, Susan

    2014-12-01

    Since about 2000, a number of federal and state policies have been implemented in the United States with the intention of stemming the flow of illegal immigration. In this article, we focus on two initiatives: (1) Operation Streamline, as an example of increased border enforcement by the federal government; and (2) state-level omnibus immigration laws, as an illustration of enhanced interior enforcement by state governments. We investigate whether these policies have reduced the intentions of deported Mexican immigrants to attempt a new unauthorized crossing. Although state-level omnibus immigration laws reduce the proportion of deportees intending to attempt a new crossing, increased border enforcement has proven to be far less effective. In addition, we ascertain the human costs associated with these policies. Our findings are mixed in this regard. Noteworthy is how the adoption of more stringent interior enforcement seems to result in a "herding" or "ganging-up" effect, whereby the incidence of verbal and physical abuse rises with the number of states enacting such measures. Additionally, our estimates suggest that deportees are more likely to respond that they have risked their lives to cross into the United States as a result of enhanced border enforcement.

  8. Battery thermal management unit

    Science.gov (United States)

    Sanders, Nicholas A.

    1989-03-01

    A battery warming device has been designed which uses waste heat from an operating internal combustion engine to warm a battery. A portion of the waste heat is stored in the sensible and latent heat of a phase change type material for use in maintaining the battery temperature after the engine is shut off. The basic design of the device consists of a Phase Change Material (PCM) reservoir and a simple heat exchanger connected to the engineer's cooling system. Two types of units were built, tested and field trialed. A strap-on type which was strapped to the side of an automotive battery and was intended for the automotive after-market and a tray type on which a battery or batteries sat. This unit was intended for the heavy duty truck market. It was determined that both types of units increased the average cranking power of the batteries they were applied to. Although there were several design problems with the units such as the need for an automatic thermostatically controlled bypass valve, the overall feeling is that there is a market opportunity for both the strap-on and tray type battery warming units.

  9. Auto Body Repair. Supplementary Units. Instructor Key and Student Units.

    Science.gov (United States)

    Daniel, Linda; Muench, James F., Ed.

    These supplementary units are designed to help students with special needs learn and apply auto body repair skills. The material specifically supplements the Auto Body Repair Curriculum Guide (University of Missouri-Columbia 1988), and is intended for instructors serving the occupational needs of various categories of disadvantaged and handicapped…

  10. Assessment of Vegetation Variation on Primarily Creation Zones of the Dust Storms Around the Euphrates Using Remote Sensing Images

    Directory of Open Access Journals (Sweden)

    Jamil Amanollahi

    2012-06-01

    Full Text Available Recently, period frequency and effect domain of the dust storms that enter Iran from Iraq have increased. In this study, in addition to detecting the creation zones of the dust storms, the effect of vegetation cover variation on their creation was investigated using remote sensing. Moderate resolution image Spectroradiometer (MODIS and Landsat Thematic Mapper (TM5 have been utilized to identify the primarily creation zones of the dust storms and to assess the vegetation cover variation, respectively. Vegetation cover variation was studied using Normalized Differences Vegetation Index (NDVI obtained from band 3 and band 4 of the Landsate satellite. The results showed that the surrounding area of the Euphrates in Syria, the desert in the vicinity of this river in Iraq, including the deserts of Alanbar Province, and the north deserts of Saudi Arabia are the primarily creation zones of the dust storms entering west and south west of Iran. The results of NDVI showed that excluding the deserts in the border of Syria and Iraq, the area with very weak vegetation cover have increased between 2.44% and 20.65% from 1991 to 2009. In the meanwhile, the retention pound surface areas in the south deserts of Syria as well as the deserts in its border with Iraq have decreased 6320 and 4397 hectares, respectively. As it can be concluded from the findings, one of the main environmental parameters initiating these dust storms is the decrease in the vegetation cover in their primarily creation zones.

  11. CLINICAL OBSERVATION ON TREATMENT OF ACUTE BRONCHITIS PRIMARILY WITH PRICKING-CUPPING ON BACK-SHU POINTS

    Institute of Scientific and Technical Information of China (English)

    XU Wei-dong; ZHANG Yong-juan; YANG Jie; CHEN Xiao-xiang; LIU Yong-xiang

    2006-01-01

    Objective: To observe the clinical effect of treatment of acute bronchitis primarily with prickingcupping method on Back-shu points. Methods: The patients of acute bronchitis were randomly divided into 2groups. In the observation group, there were 36 cases, who were treated with the integrated traditional Chinese and western medicine, primarily the pricking-cupping method on Back-shu points; while in the control group, there were 29 cases who were given the conventinal treatment of western medicine. All the 2 groups were treated for 7 days as one treating course. Results: The total effective rate of the observation group was 97.2% while that of the control group was 82.8%, so there is a significant difference between them. On the first and third days the clinical manifestations were more satisfactorily improved in the treatment group than in the control group (P < 0.01 ) and on the fifth and seventh days, the comparison showed no significant difference (P >0.05). Conclusion: The treatment of acute bronchitis by means of the integrated traditional Chinese and western medicine primarily with pricking-cupping method on Back-shu points is of marked therapeutic effect, simple manipulation, and little untoward effects, thus claiming the unique advantage.

  12. Interplay Between Intended Brand Identity and Identities in a Nike Related Brand Community

    DEFF Research Database (Denmark)

    Kornum, Niels; Gyrd-Jones, Richard; Al Zagir, Nadia

    2017-01-01

    While branding research traditionally views brand identity as an inside-out management controlled phenomenon, recent research emphasizes that a wide variety of stakeholders in the brand ecosystem enact and co-create brand identity. Following this theoretical perspective, management forms......, this research compares individual and collective articulations of a Nike related brand community with articulations of the intended brand identity. While earlier findings solely emphasize inside-out brand management or outside-in brand community perspectives, the findings of this article reveal a nested system...... the intended brand identity in a deliberate process and articulates this identity, surfacing as values and artifacts. Stakeholders develop and articulate values and artifacts in their own manner, but enact the brand identity at the same time. On the basis of data from a participatory ethnographic study...

  13. Volunteer Tourists' Intended Behavior Using the Revised Theory of Planned Behavior

    OpenAIRE

    Lee, Seungwoo

    2011-01-01

    Volunteer tourism as an alternative to mass tourism has grown significantly since the 1970s, sparking research interest in the subject. However, there is little research that has examined future potential volunteer touristsâ various perceptions, needs and wants. The purpose of this study was to understand how and in what way various potential volunteer touristsâ beliefs, including attitudes, subjective norms, self-efficacy and motivation, influence their future intended participation in a...

  14. Improving brain-machine interface performance by decoding intended future movements

    Science.gov (United States)

    Willett, Francis R.; Suminski, Aaron J.; Fagg, Andrew H.; Hatsopoulos, Nicholas G.

    2013-04-01

    Objective. A brain-machine interface (BMI) records neural signals in real time from a subject's brain, interprets them as motor commands, and reroutes them to a device such as a robotic arm, so as to restore lost motor function. Our objective here is to improve BMI performance by minimizing the deleterious effects of delay in the BMI control loop. We mitigate the effects of delay by decoding the subject's intended movements a short time lead in the future. Approach. We use the decoded, intended future movements of the subject as the control signal that drives the movement of our BMI. This should allow the user's intended trajectory to be implemented more quickly by the BMI, reducing the amount of delay in the system. In our experiment, a monkey (Macaca mulatta) uses a future prediction BMI to control a simulated arm to hit targets on a screen. Main Results. Results from experiments with BMIs possessing different system delays (100, 200 and 300 ms) show that the monkey can make significantly straighter, faster and smoother movements when the decoder predicts the user's future intent. We also characterize how BMI performance changes as a function of delay, and explore offline how the accuracy of future prediction decoders varies at different time leads. Significance. This study is the first to characterize the effects of control delays in a BMI and to show that decoding the user's future intent can compensate for the negative effect of control delay on BMI performance.

  15. Depth evaluation of intended vs actual intacs intrastromal ring segments using optical coherence tomography.

    Science.gov (United States)

    Barbara, R; Barbara, A; Naftali, M

    2016-01-01

    PurposeEvaluation of actual vs intended intrastromal corneal ring segments (ICRS) implantation depth as measured by anterior segment optical coherence tomography (OCT)MethodsProspective study evaluating 30 Intacs segments implanted manually in 19 eyes of 15 patients suffering from keratoconus. Segment depth evaluation was performed using anterior segment OCT. Measurements were performed above and below the segment at 3 points in relation to the incision site. Statistical analysis was performed using the SAS software for ANOVA, matched t-test, and GLIMMIX procedure.ResultsIntacs segment depth was 153-μm shallower than intended (58% vs 80%). Segment layout demonstrated the proximal and distal portions to be 13-μm shallower and 12-μm deeper (on average), respectively. Intacs segment thickness does not influence implantation depth. Intacs segments implanted in the same eye do not share similar implantation depths. Stromal compression is likely to occur.ConclusionIntacs are implanted at a shallower depth than intended. The 'pocketing' stage prior to implantation most likely has a stronger effect on the segment's final implantation depth than does the incisions' depth.

  16. [Facial pain- a rare cause. Impacted lower third molars causing primarily "unclear" facial pain: a case report].

    Science.gov (United States)

    Gander, Thomas; Dagassan-Berndt, Dorothea; Mascolo, Luana; Kruse, Astrid L; Grätz, Klaus W; Lübbers, Heinz-Theo

    2013-01-01

    Orofacial pain often causes special difficulties to patients and dentists. Numerous differential diagnoses require the utilization of a coordinated diagnostic concept. Often, multiple causes lead to the need for a complex treatment plan. Impacted third molars are a potential cause of a variety of complications. Caries, pulp necrosis, and periapical infection are some of the infrequent causes of such pain. The presented case shows just such a constellation, resulting in primarily "unclear" orofacial pain. A diagnostic sequence generally leads to the correct diagnosis and thereby allows for fast and effective therapy. This shows how important structured diagnostics are, especially in cases of "unclear" pain.

  17. Introduction to Agribusiness. Unit A-6.

    Science.gov (United States)

    Luft, Vernon D.; Backlund, Paul

    This secondary curriculum guides is comprised of two jobs (units of instruction) designed to introduce students to Agribusiness. An introductory section lists the jobs included in the guide, intended use, unit objectives, and references. Jobs included are (1) Understanding the Importance of Agribusiness and (2) Defining Types of Business…

  18. SPOKEN COCHABAMBA QUECHUA, UNITS 13-24.

    Science.gov (United States)

    LASTRA, YOLANDA; SOLA, DONALD F.

    UNITS 13-24 OF THE SPOKEN COCHABAMBA QUECHUA COURSE FOLLOW THE GENERAL FORMAT OF THE FIRST VOLUME (UNITS 1-12). THIS SECOND VOLUME IS INTENDED FOR USE IN AN INTERMEDIATE OR ADVANCED COURSE AND INCLUDES MORE COMPLEX DIALOGS, CONVERSATIONS, "LISTENING-INS," AND DICTATIONS, AS WELL AS GRAMMAR AND EXERCISE SECTIONS COVERING ADDITIONAL…

  19. SPOKEN COCHABAMBA QUECHUA, UNITS 13-24.

    Science.gov (United States)

    LASTRA, YOLANDA; SOLA, DONALD F.

    UNITS 13-24 OF THE SPOKEN COCHABAMBA QUECHUA COURSE FOLLOW THE GENERAL FORMAT OF THE FIRST VOLUME (UNITS 1-12). THIS SECOND VOLUME IS INTENDED FOR USE IN AN INTERMEDIATE OR ADVANCED COURSE AND INCLUDES MORE COMPLEX DIALOGS, CONVERSATIONS, "LISTENING-INS," AND DICTATIONS, AS WELL AS GRAMMAR AND EXERCISE SECTIONS COVERING ADDITIONAL…

  20. SPOKEN COCHABAMBA QUECHUA, UNITS 13-24.

    Science.gov (United States)

    LASTRA, YOLANDA; SOLA, DONALD F.

    UNITS 13-24 OF THE SPOKEN COCHABAMBA QUECHUA COURSE FOLLOW THE GENERAL FORMAT OF THE FIRST VOLUME (UNITS 1-12). THIS SECOND VOLUME IS INTENDED FOR USE IN AN INTERMEDIATE OR ADVANCED COURSE AND INCLUDES MORE COMPLEX DIALOGS, CONVERSATIONS, "LISTENING-INS," AND DICTATIONS, AS WELL AS GRAMMAR AND EXERCISE SECTIONS COVERING ADDITIONAL GRAMMATICAL…

  1. ON DEVELOPING CLEANER ORGANIC UNIT PROCESSES

    Science.gov (United States)

    Organic waste products, potentially harmful to the human health and the environment, are primarily produced in the synthesis stage of manufacturing processes. Many such synthetic unit processes, such as halogenation, oxidation, alkylation, nitration, and sulfonation are common to...

  2. Intended Use of a Building in Terms of Updating the Cadastral Database and Harmonizing the Data with other Public Records

    Directory of Open Access Journals (Sweden)

    Buśko Małgorzata

    2017-06-01

    Full Text Available According to the original wording of the Regulation on the register of land and buildings of 2001, in the real estate cadastre there was one attribute associated with the use of a building structure - its intended use, which was applicable until the amendment to the Regulation was introduced in 2013. Then, additional attributes were added, i.e. the type of the building according to the Classification of Fixed Assets (KST, the class of the building according to the Polish Classification of Types of Constructions (PKOB and, at the same time, the main functional use and other functions of the building remained in the Regulation as well. The record data on buildings are captured for the real estate cadastre from other data sets, for example those maintained by architectural and construction authorities. At the same time, the data contained in the cadastre, after they have been entered or changed in the database, are transferred to other registers, such as tax records, or land and mortgage court registers. This study is the result of the analysis of the laws applicable to the specific units and registers. A list of discrepancies in the attributes occurring in the different registers was prepared. The practical part of the study paid particular attention to the legal bases and procedures for entering the function of a building in the real estate cadastre, which is extremely significant, as it is the attribute determining the property tax basis.

  3. Adaptive Management of Glen Canyon Dam: Two Decades of Large Scale Experimental Treatments Intended to Benefit Resources of the Colorado River in Grand Canyon, USA

    Science.gov (United States)

    Melis, Theodore

    2010-05-01

    Glen Canyon Dam was closed in 1963, primarily to store water for the rapidly developing southwestern United States. The dam's hydropower plant, with a generating capacity of up to 1,300 megawatts of electrical energy, was initially operated without daily peaking constraints from 1966 to 1990, resulting in daily tides on the Colorado River through Grand Canyon National Park of up to 4 meters. The influences of Glen Canyon Dam's peaking operations on downstream river resources through Grand Canyon have been intensively studied for nearly four decades. Following experimental reoperation of the dam in summer 1990, and five years of studies associated with a major environmental impact statement, the Glen Canyon Dam Adaptive Management Program was created in 1997, to evaluate whether a new experimental flow regime, combined with other non-flow treatments, can mitigate the detrimental effects of the former hydropeaking flow regime. Experimental flow treatments associated with the program over the last two decades have included the adoption of hourly and daily operating rules that now govern and constrain hydropeaking, periodic release of experimental controlled floods to rebuild sandbar habitats along shorelines and occasional steady flow tests intended to benefit the river's endangered humpback chub; one of the endemic fish of the Colorado River basin that experienced a population decline following dam closure. Other non-flow experimental treatments being evaluated by the program include removal of nonnative fish species, such as rainbow trout and other exotic fish, as well as translocation of humpback chub into other habitats below the dam where they might successfully spawn. Since 1995, three controlled flood experiments have been released from the dam to determine whether the remaining sand supplies that enter the Colorado River below the dam (about 6 to 16 percent of the predam sand supply) can be managed to create and maintain sandbar habitats used by humpback chub

  4. Assessing energy efficiency of electric car bottom furnaces intended for thermal energization of minerals

    Science.gov (United States)

    Nizhegorodov, A. I.

    2017-01-01

    The paper deals with a new concept of electric furnaces for roasting and thermal energization of vermiculite and other minerals with vibrational transportation of a single-layer mass under constant thermal field. The paper presents performance calculation and comparative assessment of energy data for furnaces of different modifications: flame and electric furnaces with three units, furnaces with six units and ones with series-parallel connection of units, and furnaces of new concept.

  5. Neonatal morbidity after spontaneous labor onset prior to intended cesarean delivery at term: a cohort study.

    Science.gov (United States)

    Glavind, Julie; Milidou, Ioanna; Uldbjerg, Niels; Maimburg, Rikke; Henriksen, Tine B

    2017-04-01

    We aimed to investigate if labor onset before planned cesarean delivery (CD) affects the risk of neonatal admission, respiratory distress, or neonatal infectious morbidity. Our cohort included singleton term pregnant women with intended CD who delivered at Aarhus University Hospital from 1990 to 2012. Two groups of women were identified: women with intended CD performed before labor (nonlabor CD) and women with intended CD performed after spontaneous labor onset (labor-onset CD); in both groups there was no other maternal or fetal medical indication for an immediate CD or for early-term CD scheduling. Data were stratified in early-term (37-38 weeks) and full-term (39-40 weeks) deliveries. The main outcome measures were neonatal admission, respiratory distress and neonatal infectious morbidity. Among 103 919 live births, 5071 deliveries were nonlabor CDs and 731 were labor-onset CDs. Compared to nonlabor CD, labor-onset CD was associated with similar risks of neonatal admission and respiratory distress, both at early and full term, but with a two- to three-fold increased risk of newborn septicemia or antibiotic treatment at early term. Labor onset at early term was associated with a lower risk of maternal blood loss of more than 500 mL, but with a higher risk of postoperative antibiotic treatment and endometritis. Labor onset before planned CD was not associated with a decrease in neonatal respiratory morbidity, but may be associated with increased risks of neonatal infection. © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.

  6. Sexual self-concept and intended sexual behavior of young adolescent Taiwanese girls.

    Science.gov (United States)

    Pai, Hsiang-Chu; Lee, Sheuan; Chang, Ting

    2010-01-01

    People begin to become aware of their sexual drive and erotic feelings as young adolescents. Such activity often has been overlooked in Taiwan, a traditional society, because sexuality is viewed as a private issue. The purpose of this study was to explore the sexual self-concept and intended sexual behavior of young adolescent girls in Taiwan. Participants included 372 girls, 12 to 14 years old, from junior high schools in Taiwan who completed two questionnaires on sexual experience and sexually related items: the Sexual Self-Concept Inventory, the Parental Approval of Sexual Behavior Scale, and the Friends' Approval of Sexual Behavior Scale, which were combined into one scale, with separate scores. Girls' self-reports showed low (negative) sexual self-concept, high perceived parental disapproval, and somewhat high perceived friends' disapproval of sexual activities. Sexual self-concept is associated with perceived parental and peer approval of sexual activities, and it is associated with sexual experience and intended sexual activities as well. A young adolescent girl who has a high score on the perceived sexual arousability factor of the Sexual Self-Concept Inventory is more likely to report the strongest intention toward sexual behavior. Sexual self-concept may play a key role in girls' intended sexual activities, including engaging in low-level sexual activities (e.g., kissing and breast fondling) that occur before intercourse, even when associated with intercourse intention. The research suggests that addressing sexual self-concept needs to be a priority to prevent young girls from engaging in sexual intercourse.

  7. Theoretical determination of the strength characteristics of multilayer materials intended for nuclear and thermonuclear engineering

    Science.gov (United States)

    Vitkovskii, I. V.; Leshukov, A. Yu.; Romashin, S. N.; Shorkin, V. S.

    2015-12-01

    A method is developed to estimate the integrity of multilayer structures. This method is based on the version of the theory of adhesion and cohesion interactions of structure elements that only takes into account their thermomechanical properties. The structures to be studied are the material of the multilayer wall of the liquid-metal thermonuclear reactor blanket and a heat-resistant magnet wire with a bimetallic conductor, which is the base of the windings of the magnetohydrodynamic machines and electric motors intended for operation at high temperatures under ionizing radiation in, e.g., the machines and facilities in nuclear and thermonuclear reactors.

  8. Multi-Province Listeriosis Outbreak Linked to Contaminated Deli Meat Consumed Primarily in Institutional Settings, Canada, 2008.

    Science.gov (United States)

    Currie, Andrea; Farber, Jeffrey M; Nadon, Céline; Sharma, Davendra; Whitfield, Yvonne; Gaulin, Colette; Galanis, Eleni; Bekal, Sadjia; Flint, James; Tschetter, Lorelee; Pagotto, Franco; Lee, Brenda; Jamieson, Fred; Badiani, Tina; MacDonald, Diane; Ellis, Andrea; May-Hadford, Jennifer; McCormick, Rachel; Savelli, Carmen; Middleton, Dean; Allen, Vanessa; Tremblay, Francois-William; MacDougall, Laura; Hoang, Linda; Shyng, Sion; Everett, Doug; Chui, Linda; Louie, Marie; Bangura, Helen; Levett, Paul N; Wilkinson, Krista; Wylie, John; Reid, Janet; Major, Brian; Engel, Dave; Douey, Donna; Huszczynski, George; Di Lecci, Joe; Strazds, Judy; Rousseau, Josée; Ma, Kenneth; Isaac, Leah; Sierpinska, Urszula

    2015-08-01

    A multi-province outbreak of listeriosis occurred in Canada from June to November 2008. Fifty-seven persons were infected with 1 of 3 similar outbreak strains defined by pulsed-field gel electrophoresis, and 24 (42%) individuals died. Forty-one (72%) of 57 individuals were residents of long-term care facilities or hospital inpatients during their exposure period. Descriptive epidemiology, product traceback, and detection of the outbreak strains of Listeria monocytogenes in food samples and the plant environment confirmed delicatessen meat manufactured by one establishment and purchased primarily by institutions was the source of the outbreak. The food safety investigation identified a plant environment conducive to the introduction and proliferation of L. monocytogenes and persistently contaminated with Listeria spp. This outbreak demonstrated the need for improved listeriosis surveillance, strict control of L. monocytogenes in establishments producing ready-to-eat foods, and advice to vulnerable populations and institutions serving these populations regarding which high-risk foods to avoid.

  9. Healthy younger and older adults control foot placement to avoid small obstacles during gait primarily by modulating step width

    Directory of Open Access Journals (Sweden)

    Schulz Brian W

    2012-10-01

    Full Text Available Abstract Background Falls are a significant problem in the older population. Most falls occur during gait, which is primarily regulated by foot placement. Variability of foot placement has been associated with falls, but these associations are inconsistent and generally for smooth, level flooring. This study investigates the control of foot placement and the associated gait variability in younger and older men and women (N=7/group, total N=28 while walking at three different speeds (slow, preferred, and fast across a control surface with no obstacles and surfaces with multiple (64 small (10cm long ×13mm high visible and hidden obstacles. Results Minimum obstacle distance between the shoe and nearest obstacle during each footfall was greater on the visible obstacles surface for older subjects because some of them chose to actively avoid obstacles. This obstacle avoidance strategy was implemented primarily by modulating step width and to a lesser extent step length as indicated by linear regressions of step width and length variability on minimum obstacle distance. Mean gait speed, step length, step width, and step time did not significantly differ by subject group, flooring surface, or obstacle avoidance strategy. Conclusions Some healthy older subjects choose to actively avoid small obstacles that do not substantially perturb their gait by modulating step width and, to a lesser extent, step length. It is not clear if this obstacle avoidance strategy is appropriate and beneficial or overcautious and maladaptive, as it results in fewer obstacles encountered at a consequence of a less efficient gait pattern that has been shown to indicate increased fall risk. Further research is needed on the appropriateness of strategy selection when the environmental demands and/or task requirements have multiple possible completion strategies with conflicting objectives (i.e. perceived safety vs. efficiency.

  10. A morphometric assessment of the intended function of cached Clovis points.

    Science.gov (United States)

    Buchanan, Briggs; Kilby, J David; Huckell, Bruce B; O'Brien, Michael J; Collard, Mark

    2012-01-01

    A number of functions have been proposed for cached Clovis points. The least complicated hypothesis is that they were intended to arm hunting weapons. It has also been argued that they were produced for use in rituals or in connection with costly signaling displays. Lastly, it has been suggested that some cached Clovis points may have been used as saws. Here we report a study in which we morphometrically compared Clovis points from caches with Clovis points recovered from kill and camp sites to test two predictions of the hypothesis that cached Clovis points were intended to arm hunting weapons: 1) cached points should be the same shape as, but generally larger than, points from kill/camp sites, and 2) cached points and points from kill/camp sites should follow the same allometric trajectory. The results of the analyses are consistent with both predictions and therefore support the hypothesis. A follow-up review of the fit between the results of the analyses and the predictions of the other hypotheses indicates that the analyses support only the hunting equipment hypothesis. We conclude from this that cached Clovis points were likely produced with the intention of using them to arm hunting weapons.

  11. A morphometric assessment of the intended function of cached Clovis points.

    Directory of Open Access Journals (Sweden)

    Briggs Buchanan

    Full Text Available A number of functions have been proposed for cached Clovis points. The least complicated hypothesis is that they were intended to arm hunting weapons. It has also been argued that they were produced for use in rituals or in connection with costly signaling displays. Lastly, it has been suggested that some cached Clovis points may have been used as saws. Here we report a study in which we morphometrically compared Clovis points from caches with Clovis points recovered from kill and camp sites to test two predictions of the hypothesis that cached Clovis points were intended to arm hunting weapons: 1 cached points should be the same shape as, but generally larger than, points from kill/camp sites, and 2 cached points and points from kill/camp sites should follow the same allometric trajectory. The results of the analyses are consistent with both predictions and therefore support the hypothesis. A follow-up review of the fit between the results of the analyses and the predictions of the other hypotheses indicates that the analyses support only the hunting equipment hypothesis. We conclude from this that cached Clovis points were likely produced with the intention of using them to arm hunting weapons.

  12. Criminalizing knowledge: the perverse implications of the intended use regulations of off-label promotion prosecutions.

    Science.gov (United States)

    Gentry, Gregory

    2009-01-01

    Your company has spent months designing a compliance program and training your sales representatives. They know never to mention the off-label uses of your product. If they are asked about the off-label uses by the physician they are detailing, they know to forward those inquiries to the scientific liaisons at headquarters. But, could your company still be in legal jeopardy simply because it knows that the product is being used for an off-label purpose? This article attempts to track the Food and Drug Administration's (FDA's) shifting interpretation of its "intended use" regulations, from focusing entirely on the statements of the manufacturers to focusing on the knowledge of the industry, indeed, of the consumers of products, in determining the true intended use of a product. It will look at several recent attempts by FDA to use that new interpretation of the regulations to expand its power: to regulate tobacco and to require pediatric indications for any new drug. Finally, it will look at several recent examples of how this new interpretation has manifested in actions by FDA and the Department of Justice (DOJ).

  13. Fluid Biomarkers of Traumatic Brain Injury and Intended Context of Use

    Science.gov (United States)

    Bogoslovsky, Tanya; Gill, Jessica; Jeromin, Andreas; Davis, Cora; Diaz-Arrastia, Ramon

    2016-01-01

    Traumatic brain injury (TBI) is one of the leading causes of death and disability around the world. The lack of validated biomarkers for TBI is a major impediment to developing effective therapies and improving clinical practice, as well as stimulating much work in this area. In this review, we focus on different settings of TBI management where blood or cerebrospinal fluid (CSF) biomarkers could be utilized for predicting clinically-relevant consequences and guiding management decisions. Requirements that the biomarker must fulfill differ based on the intended context of use (CoU). Specifically, we focus on fluid biomarkers in order to: (1) identify patients who may require acute neuroimaging (cranial computerized tomography (CT) or magnetic resonance imaging (MRI); (2) select patients at risk for secondary brain injury processes; (3) aid in counseling patients about their symptoms at discharge; (4) identify patients at risk for developing postconcussive syndrome (PCS), posttraumatic epilepsy (PTE) or chronic traumatic encephalopathy (CTE); (5) predict outcomes with respect to poor or good recovery; (6) inform counseling as to return to work (RTW) or to play. Despite significant advances already made from biomarker-based studies of TBI, there is an immediate need for further large-scale studies focused on identifying and innovating sensitive and reliable TBI biomarkers. These studies should be designed with the intended CoU in mind. PMID:27763536

  14. Fluid Biomarkers of Traumatic Brain Injury and Intended Context of Use

    Directory of Open Access Journals (Sweden)

    Tanya Bogoslovsky

    2016-10-01

    Full Text Available Traumatic brain injury (TBI is one of the leading causes of death and disability around the world. The lack of validated biomarkers for TBI is a major impediment to developing effective therapies and improving clinical practice, as well as stimulating much work in this area. In this review, we focus on different settings of TBI management where blood or cerebrospinal fluid (CSF biomarkers could be utilized for predicting clinically-relevant consequences and guiding management decisions. Requirements that the biomarker must fulfill differ based on the intended context of use (CoU. Specifically, we focus on fluid biomarkers in order to: (1 identify patients who may require acute neuroimaging (cranial computerized tomography (CT or magnetic resonance imaging (MRI; (2 select patients at risk for secondary brain injury processes; (3 aid in counseling patients about their symptoms at discharge; (4 identify patients at risk for developing postconcussive syndrome (PCS, posttraumatic epilepsy (PTE or chronic traumatic encephalopathy (CTE; (5 predict outcomes with respect to poor or good recovery; (6 inform counseling as to return to work (RTW or to play. Despite significant advances already made from biomarker-based studies of TBI, there is an immediate need for further large-scale studies focused on identifying and innovating sensitive and reliable TBI biomarkers. These studies should be designed with the intended CoU in mind.

  15. Decoding of intended saccade direction in an oculomotor brain-computer interface

    Science.gov (United States)

    Jia, Nan; Brincat, Scott L.; Salazar-Gómez, Andrés F.; Panko, Mikhail; Guenther, Frank H.; Miller, Earl K.

    2017-08-01

    Objective. To date, invasive brain-computer interface (BCI) research has largely focused on replacing lost limb functions using signals from the hand/arm areas of motor cortex. However, the oculomotor system may be better suited to BCI applications involving rapid serial selection from spatial targets, such as choosing from a set of possible words displayed on a computer screen in an augmentative and alternative communication (AAC) application. Here we aimed to demonstrate the feasibility of a BCI utilizing the oculomotor system. Approach. We developed a chronic intracortical BCI in monkeys to decode intended saccadic eye movement direction using activity from multiple frontal cortical areas. Main results. Intended saccade direction could be decoded in real time with high accuracy, particularly at contralateral locations. Accurate decoding was evident even at the beginning of the BCI session; no extensive BCI experience was necessary. High-frequency (80-500 Hz) local field potential magnitude provided the best performance, even over spiking activity, thus simplifying future BCI applications. Most of the information came from the frontal and supplementary eye fields, with relatively little contribution from dorsolateral prefrontal cortex. Significance. Our results support the feasibility of high-accuracy intracortical oculomotor BCIs that require little or no practice to operate and may be ideally suited for ‘point and click’ computer operation as used in most current AAC systems.

  16. The what, how much, and when of study strategies: comparing intended versus actual study behaviour.

    Science.gov (United States)

    Blasiman, Rachael N; Dunlosky, John; Rawson, Katherine A

    2017-07-01

    The study behaviours of students can be assessed from several perspectives, such as what study strategies are used, the total number of hours of study, and the distribution of studying over time. Here, we present the results of a survey study that considered each of these perspectives by asking students to report the what, how much, and when of their study behaviours over the course of a semester. As important, to better understand students' use of study strategies, we also had students report at the beginning of the semester how they intended to study and their beliefs about the effectiveness of a variety of common strategies. Our results indicate that during the semester, students rely on relatively ineffective strategies and mass their studying the day or two before an exam. However, students intended to begin studying earlier and to use a mix of effective and ineffective study habits. Despite their use of some ineffective strategies, they did have a relatively accurate assessment of which strategies were less versus more effective. Taken together, our results suggest that students have some excellent intentions but may falter because massing study the evening before an exam limits their use of more effective study strategies.

  17. Determination of origin and intended use of plutonium metal using nuclear forensic techniques.

    Science.gov (United States)

    Rim, Jung H; Kuhn, Kevin J; Tandon, Lav; Xu, Ning; Porterfield, Donivan R; Worley, Christopher G; Thomas, Mariam R; Spencer, Khalil J; Stanley, Floyd E; Lujan, Elmer J; Garduno, Katherine; Trellue, Holly R

    2017-04-01

    Nuclear forensics techniques, including micro-XRF, gamma spectrometry, trace elemental analysis and isotopic/chronometric characterization were used to interrogate two, potentially related plutonium metal foils. These samples were submitted for analysis with only limited production information, and a comprehensive suite of forensic analyses were performed. Resulting analytical data was paired with available reactor model and historical information to provide insight into the materials' properties, origins, and likely intended uses. Both were super-grade plutonium, containing less than 3% (240)Pu, and age-dating suggested that most recent chemical purification occurred in 1948 and 1955 for the respective metals. Additional consideration of reactor modeling feedback and trace elemental observables indicate plausible U.S. reactor origin associated with the Hanford site production efforts. Based on this investigation, the most likely intended use for these plutonium foils was (239)Pu fission foil targets for physics experiments, such as cross-section measurements, etc. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. 21 CFR 701.20 - Detergent substances, other than soap, intended for use in cleansing the body.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Detergent substances, other than soap, intended... Ingredients § 701.20 Detergent substances, other than soap, intended for use in cleansing the body. (a) In its definition of the term cosmetic, the Federal Food, Drug, and Cosmetic Act specifically excludes soap....

  19. 16 CFR 1500.48 - Technical requirements for determining a sharp point in toys and other articles intended for use...

    Science.gov (United States)

    2010-01-01

    ... sharp point in toys and other articles intended for use by children under 8 years of age. 1500.48... requirements for determining a sharp point in toys and other articles intended for use by children under 8... used by the Commission in making a preliminary determination that points on toys and other...

  20. Success factors for the implementation of an intended brand personality : Conceptual framework and insights from the Swiss luxury industry

    NARCIS (Netherlands)

    Hoyer, Wayne D.; Krohmer, Harley; Lobschat, Lara

    2015-01-01

    The creation and implementation of an intended brand personality has become a prevailing topic, both for practitioners and researchers. Especially in luxury industry, where brands hold a strong symbolic meaning, marketers are faced with the challenge of successfully establishing an intended brand

  1. Who Has the Advantages in My Intended Career? Engaging Students in the Identification of Gender and Racial Inequalities

    Science.gov (United States)

    Sweet, Stephen; Baker, Kimberly M.

    2011-01-01

    This article describes and assesses two learning modules designed to make students aware of gender and racial inequalities present in their own intended careers. Students identify their intended occupation in respect to the Standard Occupational Classification system and then use that code to determine the composition and earnings in that…

  2. Success factors for the implementation of an intended brand personality : Conceptual framework and insights from the Swiss luxury industry

    NARCIS (Netherlands)

    Hoyer, Wayne D.; Krohmer, Harley; Lobschat, Lara

    2015-01-01

    The creation and implementation of an intended brand personality has become a prevailing topic, both for practitioners and researchers. Especially in luxury industry, where brands hold a strong symbolic meaning, marketers are faced with the challenge of successfully establishing an intended brand pe

  3. Success Factors for the Implementation of an Intended Brand Personality : Conceptual Framework and Empirical Study in the Swiss Luxury Industry

    NARCIS (Netherlands)

    Hoyer, Wayne D.; Krohmer, Harley; Lobschat, Lara

    2015-01-01

    The creation and implementation of an intended brand personality has become a prevailing topic, both for practitioners and researchers. Especially in luxury industry, where brands hold a strong symbolic meaning, marketers are faced with the challenge of successfully establishing an intended brand pe

  4. History of United States Energy. A Basic Teaching Unit on Energy. Revised.

    Science.gov (United States)

    McDermott, Hugh, Ed.; Scharmann, Larry, Ed.

    Intended as a supplement to the units "Oil: Fuel of the Past" and "Coal: Fuel of the Past, Hope of the Future," this 3-4 day unit contains three activities which briefly explain the chronological development of energy resources and the formation and development of the Organization of Petroleum Exporting Countries (OPEC). The…

  5. Human land uses enhance sediment denitrification and N2O production in Yangtze lakes primarily by influencing lake water quality

    Directory of Open Access Journals (Sweden)

    W. Liu

    2015-05-01

    Full Text Available Sediment denitrification in lakes alleviates the effects of eutrophication through removal of nitrogen to the atmosphere as N2O and N2. However, N2O contributes notably to the greenhouse effect and global warming. Human lands uses (e.g., agricultural and urban areas strongly affect lake water quality and sediment characteristics, which, in turn, may regulate lake sediment denitrification and N2O production. In this study, we investigated sediment denitrification and N2O production and their relationships to within-lake variables and watershed land uses in 20 lakes from the Yangtze River basin in China. The results indicated that both lake water quality and sediment characteristics were significantly influenced by watershed land uses. Increased background denitrification rate would result in increased N2O production rate. Background denitrification and N2O production rates were positively related to water nitrogen concentrations but were not significantly correlated with sediment characteristics and plant community structure. A significant positive relationship was observed between background denitrification rate and percentage of human-dominated land uses (HDL in watersheds. Structural equation modelling revealed that the indirect effects of HDL on sediment denitrification and N2O production in Yangtze lakes were mediated primarily through lake water quality. Our findings also suggest that although sediments in Yangtze lakes can remove large quantities of nitrogen through denitrification, they may also be an important source of N2O, especially in lakes with high nitrogen content.

  6. Patient-Provider Engagement and Chronic Pain in Drug-Using, Primarily African American Persons Living with HIV/AIDS.

    Science.gov (United States)

    Mitchell, Mary M; Nguyen, Trang Q; Maragh-Bass, Allysha C; Isenberg, Sarina R; Beach, Mary Catherine; Knowlton, Amy R

    2016-10-27

    Among disadvantaged persons living with HIV/AIDS (PLHIV), patient-provider engagement, which has been defined as patient-provider relationships that promote the use of health care services and are characterized by active listening and supportive decision making, has been associated with antiretroviral therapy (ART) maintenance and viral suppression. However, chronic pain, depression, and substance use, all of which are prevalent in this population, can reduce the quality of patient-provider engagement. We hypothesized a model in which chronic pain, depression, and substance use would be associated with poorer patient-provider engagement, which would be positively associated with adherence, with the latter associated positively with viral suppression. We analyzed data from the BEACON study, which included surveys from 383 PLHIV who were primarily African American, on ART, and had histories of drug use. Due to six missing cases on the chronic pain variable, we used data from 377 respondents in a structural equation model. Chronic pain and depressive symptoms were significantly associated with poorer patient-provider engagement, while substance use was associated with better engagement. Patient-provider engagement in turn was associated with better ART adherence, which was associated with higher viral suppression. Results suggest the role of chronic pain in poor patient-physician engagement in this population, which has potential implications for quality of HIV patient care and health outcomes. Findings suggest the need for attention to patient-provider engagement in PLHIV.

  7. Inverted Papilloma Originating Primarily from the Nasolacrimal Duct: A Case Report and Review of the Pertinent Literature

    Directory of Open Access Journals (Sweden)

    Hussein Z. Walijee

    2015-01-01

    Full Text Available Introduction. Inverted papilloma (IP is an uncommon, benign yet aggressive neoplasm characterised by high recurrence rates and tendency towards malignant transformation. The majority of IP cases originate in the ethmoid region, lateral wall of the nasal fossa, and maxillary sinus. The authors report a case of an IP originating primarily from the nasolacrimal duct (NLD. Case. A 69-year-old Caucasian gentleman presented with a lump in his right medial canthal region, epiphora, and discharge bilaterally. Radiological investigation revealed a well-defined, heterogeneous mass within the proximal NLD eroding the bony canal, protruding into the middle meatus and into the right orbit. The tumour was excised en bloc utilizing a combined external and endoscopic approach based on its location. Histology revealed hyperplastic ribbons of basement membrane-enclosed epithelium growing endophytically into the underlying stroma with no evidence of invasive malignancy. The patient made an uneventful recovery with unchanged visual acuity and normal extraocular movements. Conclusion. The case demonstrates variability within the sinonasal tract that IP can develop and the individuality of each case necessitating tailored operative techniques for complete excision whilst minimising recurrence rates. We also present a combined endoscopic approach for the en bloc resection of a NLD IP with no clinical recurrence at 15-month follow-up.

  8. Chemical and biological studies of a new cigarette that primarily heats tobacco. Part 3. In vitro toxicity of whole smoke.

    Science.gov (United States)

    Bombick, D W; Ayres, P H; Putnam, K; Bombick, B R; Doolittle, D J

    1998-03-01

    Mainstream smoke from Kentucky reference low "tar" (1R4F) and ultra-low "tar" (1R5F) cigarettes and a test cigarette (TOB-HT), that primarily heats tobacco, was compared for cytotoxic and genotoxic potential using cellular smoke exposure technology (CSET). CSET includes a computer controlled 30-port AMESA/Battelle-Geneva smoke generator which exposes cultured mammalian Chinese hamster ovary cells (CHO) to whole smoke. Cytotoxicity was assessed using the neutral red assay and genotoxicity was assessed using the sister chromatid exchange (SCE) assay. Compared on a per cigarette basis, mainstream smoke from 1R5F and the TOB-HT cigarette was significantly less cytotoxic and genotoxic than the smoke from the 1R4F cigarette. The cytotoxic and genotoxic activity of smoke from the TOB-HT cigarettes was slightly greater than the smoke from the ultra-low "tar" Kentucky 1R5F reference cigarettes. In conclusion, in these assays mainstream whole smoke of the TOB-HT cigarette had slightly greater cytotoxic and genotoxic potential compared with an ultra-low "tar" 1R5F Kentucky reference cigarette and significantly less activity compared with the whole mainstream smoke from a low "tar" 1R4F Kentucky reference cigarette, representative of the US market average cigarette for FTC yields of "tar", CO and nicotine.

  9. TUMOR NECROSIS FACTOR ALPHA DECREASES NOS3 EXPRESSION PRIMARILY VIA RHO/RHO KINASE IN THE THICK ASCENDING LIMB

    Science.gov (United States)

    Ramseyer, Vanesa; Hong, Nancy; Garvin, Jeffrey L.

    2013-01-01

    Inappropriate Na+ reabsorption by thick ascending limbs (THALs) induces hypertension. Nitric oxide (NO) produced by NO synthase type 3 (NOS3 or eNOS) inhibits NaCl reabsorption by THALs. Tumor necrosis factor alpha (TNF-α) decreases NOS3 expression in endothelial cells and contributes to increases in blood pressure. However, the effects of TNF-α on THAL NOS3 and the signaling cascade are unknown. TNF-α activates several signaling pathways including Rho/Rho kinase (ROCK) which is known to reduce NOS3 expression in endothelial cells. Therefore, we hypothesized that TNF-α decreases NOS3 expression via Rho/ROCK in rat THAL primary cultures. THAL cells were incubated with either vehicle or 1 nmol/L TNF-α for 24 hrs and NOS3 expression was measured by Western blot. TNF-α decreased NOS3 expression by 51±6% (pNOS3 expression by 30±8% (pNOS3 expression by 66±15 % (pNOS3 expression. We conclude that TNF-α decreases NOS3 expression primarily via Rho/ROCK in rat THALs. These data suggest that some of the beneficial effects of ROCK inhibitors in hypertension could be due to the mitigation of TNF-α-induced reduction in NOS3 expression. PMID:22566503

  10. Adolescent Pornography Use and Dating Violence among a Sample of Primarily Black and Hispanic, Urban-Residing, Underage Youth

    Directory of Open Access Journals (Sweden)

    Emily F. Rothman

    2015-12-01

    Full Text Available This cross-sectional study was designed to characterize the pornography viewing preferences of a sample of U.S.-based, urban-residing, economically disadvantaged, primarily Black and Hispanic youth (n = 72, and to assess whether pornography use was associated with experiences of adolescent dating abuse (ADA victimization. The sample was recruited from a large, urban, safety net hospital, and participants were 53% female, 59% Black, 19% Hispanic, 14% Other race, 6% White, and 1% Native American. All were 16–17 years old. More than half (51% had been asked to watch pornography together by a dating or sexual partner, and 44% had been asked to do something sexual that a partner saw in pornography. Adolescent dating abuse (ADA victimization was associated with more frequent pornography use, viewing pornography in the company of others, being asked to perform a sexual act that a partner first saw in pornography, and watching pornography during or after marijuana use. Approximately 50% of ADA victims and 32% of non-victims reported that they had been asked to do a sexual act that their partner saw in pornography (p = 0.15, and 58% did not feel happy to have been asked. Results suggest that weekly pornography use among underage, urban-residing youth is common, and may be associated with ADA victimization.

  11. Adolescent Pornography Use and Dating Violence among a Sample of Primarily Black and Hispanic, Urban-Residing, Underage Youth

    Science.gov (United States)

    Rothman, Emily F.; Adhia, Avanti

    2015-01-01

    This cross-sectional study was designed to characterize the pornography viewing preferences of a sample of U.S.-based, urban-residing, economically disadvantaged, primarily Black and Hispanic youth (n = 72), and to assess whether pornography use was associated with experiences of adolescent dating abuse (ADA) victimization. The sample was recruited from a large, urban, safety net hospital, and participants were 53% female, 59% Black, 19% Hispanic, 14% Other race, 6% White, and 1% Native American. All were 16–17 years old. More than half (51%) had been asked to watch pornography together by a dating or sexual partner, and 44% had been asked to do something sexual that a partner saw in pornography. Adolescent dating abuse (ADA) victimization was associated with more frequent pornography use, viewing pornography in the company of others, being asked to perform a sexual act that a partner first saw in pornography, and watching pornography during or after marijuana use. Approximately 50% of ADA victims and 32% of non-victims reported that they had been asked to do a sexual act that their partner saw in pornography (p = 0.15), and 58% did not feel happy to have been asked. Results suggest that weekly pornography use among underage, urban-residing youth may be common, and may be associated with ADA victimization. PMID:26703744

  12. Liquid chromatographic determination of residual isocyanate monomers in plastics intended for food contact use.

    Science.gov (United States)

    Damant, A P; Jickells, S M; Castle, L

    1995-01-01

    A liquid chromatographic (LC) method was developed for the analysis of 10 isocyanates in polyurethane articles and laminates intended for food use. Residual isocyanates are extracted by dichloromethane with concurrent derivatization by 9-(methylaminomethyl)anthracene. The resultant derivatives are analyzed by reversed-phase LC with fluorescence detection. Separation of the isocyanates was studied and optimized. Quantitation uses 1-naphthyl isocyanate as internal standard and standard addition to the food package. Validation demonstrated the method to have good precision (+/- 2-5%) and recovery (83-95%) for samples spiked with isocyanates at 0.1 mg/kg. The limit of detection was 0.03 mg/kg. Analysis of 19 commercial polyurethane or laminate food packages demonstrated that the method was not prone to interferences. Residues of diphenylmethane-4,4'-diisocyanate were detected in 5 packages and ranged from 0.14 to 1.08 mg/kg.

  13. Safety of parsley intended for processing depending on the cultivation technology and storage

    Directory of Open Access Journals (Sweden)

    Pobereżny Jarosław

    2016-09-01

    Full Text Available The factors that affect the value of parsley for consumption include its taste, flavour and dietary utility (vitamins C and E, β-carotene, potassium, calcium, phosphorus and iron, raw fibre, proteins as well as the content of hazardous substances, especially nitrogen compounds. A study was carried out in 2013–2015 to determine the effect of the cultivation technology and storage on the safety of parsley intended for processing. The study material was taken from an experiment where the following fertilisers were applied to the ground: nitrogen (0, 40, 80, 120 kg N∙ha−1 and magnesium (0; 30 kg Mg∙ha−1. Parsley roots were stored for six months in a storage room at +1°C and RH 95%. The content of nitrates (V and (III was determined by the ion selective method immediately after the harvest and after storage in parsley roots.

  14. Can you design for Fidelity? How your intervention framework describes intended actions, participation and behavior

    DEFF Research Database (Denmark)

    Poulsen, Signe; Gish, Liv; Ipsen, Christine

    In recent years the term fidelity has been introduced within the field of organizational level interventions. Fidelity describes the extent to which the intervention has been implemented as it was originally intended, and is regarded critical for determining the validity of the research results...... in organizational level interventions. The concept of fidelity stems from clinical interventions although the concept has developed over time (Bellg et al. 2004). Organizational level interventions differ from clinical interventions, as they are more complex regarding both the “dose” given and the number and levels...... of participants involved at the same time. Steering organizational level interventions in every detail and secure full fidelity or treatment integrity can thus seem difficult. Organizational level intervention frameworks are often built on the designer’s experiences with previous interventions as well as what...

  15. Sound classification schemes in Europe - Quality classes intended for renovated housing

    DEFF Research Database (Denmark)

    Rasmussen, Birgit

    2010-01-01

    According to social surveys in several European countries, occupants of multifamily housing are considerably annoyed by noise from neighbours’ activities. The noise issue has also received increasing attention from WHO. Neighbour noise has been identified as a health problem and reduction of noise...... exposure in the home included in the proposed main objectives for a housing policy. In most countries in Europe, building regulations specify minimum requirements concerning acoustical conditions for new dwellings. In addition, several countries have introduced sound classification schemes with classes...... intended to reflect different levels of acoustical comfort. Consequently, acoustic requirements for a dwelling can be specified as the legal minimum requirements or as a specific class in a classification scheme. Most schemes have both higher classes than corresponding to the regulatory requirements...

  16. Neonatal morbidity after spontaneous labor onset prior to intended cesarean delivery at term

    DEFF Research Database (Denmark)

    Glavind, Julie; Milidou, Ioanna; Uldbjerg, Niels;

    2017-01-01

    INTRODUCTION: We aimed to investigate if labor onset before planned cesarean delivery (CD) affects the risk of neonatal admission, respiratory distress, or neonatal infectious morbidity. MATERIAL AND METHODS: Our cohort included singleton term pregnant women with intended CD who delivered at Aarhus...... for an immediate CD or for early term CD scheduling. Data were stratified in early term (37-38 weeks) and full term (39-40 weeks) deliveries. The main outcome measures were neonatal admission, respiratory distress, and neonatal infectious morbidity. RESULTS: Among 103 919 live births, 5071 deliveries were non......-labor CDs and 731 were labor onset CDs. Compared to non-labor CD, labor onset CD was associated with similar risks of neonatal admission and respiratory distress, both at early and full term, but with a 2-3 fold increased risk of newborn septicemia or antibiotic treatment at early term. Labor onset at early...

  17. Corpora of Vietnamese texts: lexical effects of intended audience and publication place.

    Science.gov (United States)

    Pham, Giang; Kohnert, Kathryn; Carney, Edward

    2008-02-01

    This article has two primary aims. The first is to introduce a new Vietnamese text-based corpus. The Corpora of Vietnamese Texts (CVT; Tang, 2006a) consists of approximately 1 million words drawn from newspapers and children's literature, and is available online at www.vnspeechtherapy.com/vi/CVT. The second aim is to investigate potential differences in lexical frequency and distributional characteristics in the CVT on the basis of place of publication (Vietnam or Western countries) and intended audience: adult-directed texts (newspapers) or child-directed texts (children's literature). We found clear differences between adult- and child-directed texts, particularly in the distributional frequencies of pronouns or kinship terms, which were more frequent in children's literature. Within child- and adult-directed texts, lexical characteristics did not differ on the basis of place of publication. Implications of these findings for future research are discussed.

  18. Was it designed to do that? Children's focus on intended function in their conceptualization of artifacts.

    Science.gov (United States)

    Asher, Yvonne M; Kemler Nelson, Deborah G

    2008-01-01

    Do young children who seek the conceptual kind of an artifact weigh the plausibility that a current function constitutes the function intended by the object designer? Three- and four-year-olds were encouraged to question adults about novel artifacts. After inquiring about what an object was, some children were shown a function that plausibly accounted for the structural features of the object; others were shown a possible, but implausible function. Children given implausible functions were less satisfied with these responses than those given plausible functions, as shown by their more persistent attempts to ask follow-up questions about function. Accordingly, preschoolers appear to take into account matters of intentional design when assigning artifacts to conceptual kinds.

  19. Injectable iron-modified apatitic bone cement intended for kyphoplasty: cytocompatibility study.

    Science.gov (United States)

    Vlad, M D; del Valle, L J; Poeata, I; Barracó, M; López, J; Torres, R; Fernández, E

    2008-12-01

    In this study, the cytocompatibility of human ephitelial (HEp-2) cells cultured on new injectable iron-modified calcium phosphate cements (IM-CPCs) has been investigated in terms of cell adhesion, cell proliferation, and morphology. Quantitative MTT-assay and scanning electron microscopy (SEM) showed that cell adhesion and viability were not affected with culturing time by iron concentration in a dose-dependent manner. SEM-cell morphology showed that HEp-2 cells, seeded on IM-CPCs, were able to adhere, spread, and attain normal morphology. These results showed that the new injectable IM-CPCs have cytocompatible features of interest to the intended kyphophasty application, for the treatment of osteoporotic vertebral compression fractures.

  20. Prevalence of radiographic changes in yearling and 2-year-old Quarter Horses intended for cutting.

    Science.gov (United States)

    Contino, E K; Park, R D; McIlwraith, C W

    2012-03-01

    There have been many studies that document radiographic findings in young Thoroughbred and Standardbred horses. No such studies have been performed in Quarter Horses. To describe the prevalence of radiographic changes in the stifles, tarsi, carpi and fetlocks of young Quarter Horses intended for cutting. Radiographs of yearling and 2-year-old Quarter Horses were obtained from a radiograph repository and a private farm. The carpi, tarsi, fetlocks and stifles were evaluated and radiographic changes categorised by type and location. The frequency of changes was calculated and comparisons were made between the 2 age groups. Of 458 included horses, 408 (89.1%) had radiographic changes, most of which were in the tarsi (304, 69.4%) followed by the stifles (202, 44.5%), hind fetlocks (155 of 355, 43.7%), fore fetlocks (131 of 361, 36.3%) and carpi (27 of 342, 7.9%). Of the horses with stifle changes, 188 (93.1%) were in the medial femoral condyle (MFC). There was a significant difference between the age groups for changes on the distal intermediate ridge of the tibia (DIRT), hindlimb middle phalanx (P2) osteophytes and proximal tibial osteophytes. There is a high prevalence of radiographic changes in presale survey radiographs, especially in the stifles and tarsi, of young Quarter Horses intended for cutting. Veterinarians examining presale radiographs at cutting horse sales should expect a high prevalence of radiographic changes in this population of horses. Work to determine the clinical relevance of these radiographic changes is currently ongoing. © 2011 EVJ Ltd.

  1. Spectroscopic characterization of novel multilayer mirrors intended for astronomical and laboratory applications

    Science.gov (United States)

    Ragozin, Eugene N.; Mednikov, Konstantin N.; Pertsov, Andrei A.; Pirozhkov, Alexander S.; Reva, Anton A.; Shestov, Sergei V.; Ul'yanov, Artem S.; Vishnyakov, Eugene A.

    2009-05-01

    We report measurements of the reflection spectra of (i) concave (spherical and parabolic) Mo/Si, Mg/Si, and Al/Zr multilayer mirrors (MMs) intended for imaging solar spectroscopy in the framework of the TESIS/CORONAS-FOTON Satellite Project and of (ii) an aperiodic Mo/Si MM optimized for maximum uniform reflectivity in the 125-250 Å range intended for laboratory applications. The reflection spectra were measured in the configuration of a transmission grating spectrometer employing the radiation of a tungsten laser-driven plasma as the source. The function of detectors was fulfilled by backside-illuminated CCDs coated with Al or Zr/Si multilayer absorption filters. High-intensity second-order interference reflection peaks at wavelengths of about 160 Å were revealed in the reflection spectra of the 304-Å Mo/Si MMs. By contrast, the second-order reflection peak in the spectra of the new-generation narrow-band (~12 Å FWHM) 304-Å Mg/Si MMs is substantially depressed. Manifestations of the NEXAFS structure of the L2, 3 absorption edges of Al and Al2O3 were observed in the spectra recorded. The broadband Mo/Si MM was employed as the focusing element of spectrometers in experiments involving (i) the charge exchange of multiply charged ions with the donor atoms of a rare-gas jet; (ii) the spectroscopic characterization of a debris-free soft X-ray radiation source excited by Nd laser pulses in a Xe jet (iii) near-IR-to-soft-X-ray frequency conversion (double Doppler effect) occurring in the retroreflection from the relativistic electron plasma wake wave (flying mirror) driven by a multiterawatt laser in a pulsed helium jet.

  2. 21 CFR 886.4250 - Ophthalmic electrolysis unit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic electrolysis unit. 886.4250 Section 886...) MEDICAL DEVICES OPHTHALMIC DEVICES Surgical Devices § 886.4250 Ophthalmic electrolysis unit. (a) Identification. An ophthalmic electrolysis unit is an AC-powered or battery-powered device intended to...

  3. 21 CFR 890.5950 - Powered heating unit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Powered heating unit. 890.5950 Section 890.5950...) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5950 Powered heating unit. (a) Identification. A powered heating unit is a device intended for medical purposes...

  4. 21 CFR 872.6510 - Oral irrigation unit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Oral irrigation unit. 872.6510 Section 872.6510...) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6510 Oral irrigation unit. (a) Identification. An oral irrigation unit is an AC-powered device intended to provide a pressurized stream of water...

  5. Y-Chromosomal Diversity in Europe Is Clinal and Influenced Primarily by Geography, Rather than by Language

    Science.gov (United States)

    Rosser, Zoë H.; Zerjal, Tatiana; Hurles, Matthew E.; Adojaan, Maarja; Alavantic, Dragan; Amorim, António; Amos, William; Armenteros, Manuel; Arroyo, Eduardo; Barbujani, Guido; Beckman, Gunhild; Beckman, Lars; Bertranpetit, Jaume; Bosch, Elena; Bradley, Daniel G.; Brede, Gaute; Cooper, Gillian; Côrte-Real, Helena B. S. M.; de Knijff, Peter; Decorte, Ronny; Dubrova, Yuri E.; Evgrafov, Oleg; Gilissen, Anja; Glisic, Sanja; Gölge, Mukaddes; Hill, Emmeline W.; Jeziorowska, Anna; Kalaydjieva, Luba; Kayser, Manfred; Kivisild, Toomas; Kravchenko, Sergey A.; Krumina, Astrida; Kučinskas, Vaidutis; Lavinha, João; Livshits, Ludmila A.; Malaspina, Patrizia; Maria, Syrrou; McElreavey, Ken; Meitinger, Thomas A.; Mikelsaar, Aavo-Valdur; Mitchell, R. John; Nafa, Khedoudja; Nicholson, Jayne; Nørby, Søren; Pandya, Arpita; Parik, Jüri; Patsalis, Philippos C.; Pereira, Luísa; Peterlin, Borut; Pielberg, Gerli; Prata, Maria João; Previderé, Carlo; Roewer, Lutz; Rootsi, Siiri; Rubinsztein, D. C.; Saillard, Juliette; Santos, Fabrício R.; Stefanescu, Gheorghe; Sykes, Bryan C.; Tolun, Aslihan; Villems, Richard; Tyler-Smith, Chris; Jobling, Mark A.

    2000-01-01

    Clinal patterns of autosomal genetic diversity within Europe have been interpreted in previous studies in terms of a Neolithic demic diffusion model for the spread of agriculture; in contrast, studies using mtDNA have traced many founding lineages to the Paleolithic and have not shown strongly clinal variation. We have used 11 human Y-chromosomal biallelic polymorphisms, defining 10 haplogroups, to analyze a sample of 3,616 Y chromosomes belonging to 47 European and circum-European populations. Patterns of geographic differentiation are highly nonrandom, and, when they are assessed using spatial autocorrelation analysis, they show significant clines for five of six haplogroups analyzed. Clines for two haplogroups, representing 45% of the chromosomes, are continentwide and consistent with the demic diffusion hypothesis. Clines for three other haplogroups each have different foci and are more regionally restricted and are likely to reflect distinct population movements, including one from north of the Black Sea. Principal-components analysis suggests that populations are related primarily on the basis of geography, rather than on the basis of linguistic affinity. This is confirmed in Mantel tests, which show a strong and highly significant partial correlation between genetics and geography but a low, nonsignificant partial correlation between genetics and language. Genetic-barrier analysis also indicates the primacy of geography in the shaping of patterns of variation. These patterns retain a strong signal of expansion from the Near East but also suggest that the demographic history of Europe has been complex and influenced by other major population movements, as well as by linguistic and geographic heterogeneities and the effects of drift. PMID:11078479

  6. Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level

    Energy Technology Data Exchange (ETDEWEB)

    Eisenstein, R.S.; Rosen, J.M.

    1988-08-01

    The mechanism by which individual peptide and steroid hormones and cell-substratum interactions regulate milk protein gene expression has been studied in the COMMA-D mammary epithelial cell line. In the presence of insulin, hydrocortisone, and prolactin, growth of COMMA-D cells on floating collagen gels in comparison with that on a plastic substratum resulted in a 2.5- to 3-fold increase in the relative rate of ..beta..-casein gene transcription but a 37-fold increase in ..beta..-casein mRNA accumulation. In contrast, whey acidic protein gene transcription was constitutive in COMMA-D cells grown on either substratum, but its mRNA was unstable and little intact mature mRNA was detected. Culturing COMMA-D cells on collagen also promoted increased expression of other genes expressed in differentiated mammary epithelial cells, including those encoding ..cap alpha..- and ..gamma..-casein, transferrin, malic enzyme, and phosphoenolpyruvate carboxykinase but decreased the expression of actin and histone genes. Using COMMA-D cells, the authors defined further the role of individual hormones in influencing ..beta..-casein gene transcription. With insulin alone, a basal level of ..beta..-casein gene transcription was detected in COMMA-D cells grown on floating collagen gels. Addition of prolactin but not hydrocortisone resulted in a 2.5- to 3.0-fold increase in ..beta..-casein gene transcription, but both hormones were required to elicit the maximal 73-fold induction in mRNA accumulation. The posttranscriptional effect of hormones on casein mRNA accummulation preceded any detectable changes in the relative rate of transcription. Thus, regulation by both hormones and cell substratum of casein gene expression is exerted primarily at the post transcriptional level.

  7. Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries.

    Directory of Open Access Journals (Sweden)

    Lihui Qu

    Full Text Available Endothelium lines the interior surface of vascular walls and regulates vascular tones. The endothelial cells sense and respond to chemical and mechanical stimuli in the circulation, and couple the stimulus signals to vascular smooth muscles, in which inward rectifier K+ currents (Kir play an important role. Here we applied several complementary strategies to determine the Kir subunit in primarily cultured pulmonary arterial endothelial cells (PAECs that was regulated by the Ca2+/calmodulin (CaM-dependent protein kinase II (CaMKII. In whole-cell voltage clamp, the Kir currents were sensitive to micromolar concentrations of extracellular Ba2+. In excised inside-out patches, an inward rectifier K+ current was observed with single-channel conductance 32.43 ± 0.45 pS and Popen 0.27 ± 0.04, which were consistent with known unitary conductance of Kir 2.1. RT-PCR and western blot results showed that expression of Kir 2.1 was significantly stronger than that of other subtypes in PAECs. Pharmacological analysis of the Kir currents demonstrated that insensitivity to intracellular ATP, pinacidil, glibenclamide, pH, GDP-β-S and choleratoxin suggested that currents weren't determined by KATP, Kir2.3, Kir2.4 and Kir3.x. The currents were strongly suppressed by exposure to CaMKII inhibitor W-7 and KN-62. The expression of Kir2.1 was inhibited by knocking down CaMKII. Consistently, vasodilation was suppressed by Ba2+, W-7 and KN-62 in isolated and perfused pulmonary arterial rings. These results suggest that the PAECs express an inward rectifier K+ current that is carried dominantly by Kir2.1, and this K+ channel appears to be targeted by CaMKII-dependent intracellular signaling systems.

  8. Predator effects on a detritus-based food web are primarily mediated by non-trophic interactions.

    Science.gov (United States)

    Majdi, Nabil; Boiché, Anatole; Traunspurger, Walter; Lecerf, Antoine

    2014-07-01

    Predator effects on ecosystems can extend far beyond their prey and are often not solely lethally transmitted. Change in prey traits in response to predation risk can have important repercussions on community assembly and key ecosystem processes (i.e. trait-mediated indirect effects). In addition, some predators themselves alter habitat structure or nutrient cycling through ecological engineering effects. Tracking these non-trophic pathways is thus an important, yet challenging task to gain a better grasp of the functional role of predators. Multiple lines of evidence suggest that, in detritus-based food webs, non-trophic interactions may prevail over purely trophic interactions in determining predator effects on plant litter decomposition. This hypothesis was tested in a headwater stream by modulating the density of a flatworm predator (Polycelis felina) in enclosures containing oak (Quercus robur) leaf litter exposed to natural colonization by small invertebrates and microbial decomposers. Causal path modelling was used to infer how predator effects propagated through the food web. Flatworms accelerated litter decomposition through positive effects on microbial decomposers. The biomass of prey and non-prey invertebrates was not negatively affected by flatworms, suggesting that net predator effect on litter decomposition was primarily determined by non-trophic interactions. Flatworms enhanced the deposition and retention of fine sediments on leaf surface, thereby improving leaf colonization by invertebrates - most of which having strong affinities with interstitial habitats. This predator-induced improvement of habitat availability was attributed to the sticky nature of the mucus that flatworms secrete in copious amount while foraging. Results of path analyses further indicated that this bottom-up ecological engineering effect was as powerful as the top-down effect on invertebrate prey. Our findings suggest that predators have the potential to affect substantially

  9. Transient activation of microglia following acute alcohol exposure in developing mouse neocortex is primarily driven by BAX-dependent neurodegeneration.

    Science.gov (United States)

    Ahlers, Katelin E; Karaçay, Bahri; Fuller, Leah; Bonthius, Daniel J; Dailey, Michael E

    2015-10-01

    Fetal alcohol exposure is the most common known cause of preventable mental retardation, yet we know little about how microglia respond to, or are affected by, alcohol in the developing brain in vivo. Using an acute (single day) model of moderate (3 g/kg) to severe (5 g/kg) alcohol exposure in postnatal day (P) 7 or P8 mice, we found that alcohol-induced neuroapoptosis in the neocortex is closely correlated in space and time with the appearance of activated microglia near dead cells. The timing and molecular pattern of microglial activation varied with the level of cell death. Although microglia rapidly mobilized to contact and engulf late-stage apoptotic neurons, apoptotic bodies temporarily accumulated in neocortex, suggesting that in severe cases of alcohol toxicity the neurodegeneration rate exceeds the clearance capacity of endogenous microglia. Nevertheless, most dead cells were cleared and microglia began to deactivate within 1-2 days of the initial insult. Coincident with microglial activation and deactivation, there was a transient increase in expression of pro-inflammatory factors, TNFα and IL-1β, after severe (5 g/kg) but not moderate (3 g/kg) EtOH levels. Alcohol-induced microglial activation and pro-inflammatory factor expression were largely abolished in BAX null mice lacking neuroapoptosis, indicating that microglial activation is primarily triggered by apoptosis rather than the alcohol. Therefore, acute alcohol exposure in the developing neocortex causes transient microglial activation and mobilization, promoting clearance of dead cells and tissue recovery. Moreover, cortical microglia show a remarkable capacity to rapidly deactivate following even severe neurodegenerative insults in the developing brain.

  10. 49 CFR 37.195 - Purchase or lease of OTRBs by private entities not primarily in the business of transporting people.

    Science.gov (United States)

    2010-10-01

    ... primarily in the business of transporting people. 37.195 Section 37.195 Transportation Office of the... transporting people. This section applies to all purchases or leases of new vehicles by private entities which are not primarily engaged in the business of transporting people, with respect to buses delivered...

  11. Mass social contact interventions and their effect on mental health related stigma and intended discrimination.

    Science.gov (United States)

    Evans-Lacko, Sara; London, Jillian; Japhet, Sarah; Rüsch, Nicolas; Flach, Clare; Corker, Elizabeth; Henderson, Claire; Thornicroft, Graham

    2012-06-28

    Stigma and discrimination associated with mental health problems is an important public health issue, and interventions aimed at reducing exposure to stigma and discrimination can improve the lives of people with mental health problems. Social contact has long been considered to be one of the most effective strategies for improving inter-group relations. For this study, we assess the impact of a population level social contact intervention among people with and without mental health problems. This study investigated the impact of social contact and whether presence of specific facilitating factors (equal status, common goals, cooperation and friendship potential): (1) improves intended stigmatising behaviour; (2) increases future willingness to disclose a mental health problem; and (3) promotes behaviours associated with anti-stigma campaign engagement. Two mass participation social contact programmes within England's Time to Change campaign were evaluated via a 2-part questionnaire. 403 participants completed initial questionnaires (70% paper, 30% online) and 83 completed follow-up questionnaires online 4-6 weeks later. This study investigated the impact of social contact and whether presence of specific facilitating factors (equal status, common goals, cooperation and friendship potential): (1) improves intended stigmatising behaviour; (2) increases future willingness to disclose a mental health problem; and (3) promotes behaviours associated with anti-stigma campaign engagement. Two mass participation social contact programmes within England's Time to Change campaign were evaluated via a 2-part questionnaire. 403 participants completed initial questionnaires (70% paper, 30% online) and 83 completed follow-up questionnaires online 4-6 weeks later. Campaign events facilitated meaningful intergroup social contact between individuals with and without mental health problems. Presence of facilitating conditions predicted improved stigma-related behavioural intentions

  12. Mass social contact interventions and their effect on mental health related stigma and intended discrimination

    Directory of Open Access Journals (Sweden)

    Evans-Lacko Sara

    2012-06-01

    Full Text Available Abstract Background Stigma and discrimination associated with mental health problems is an important public health issue, and interventions aimed at reducing exposure to stigma and discrimination can improve the lives of people with mental health problems. Social contact has long been considered to be one of the most effective strategies for improving inter-group relations. For this study, we assess the impact of a population level social contact intervention among people with and without mental health problems. Methods This study investigated the impact of social contact and whether presence of specific facilitating factors (equal status, common goals, cooperation and friendship potential: (1 improves intended stigmatising behaviour; (2 increases future willingness to disclose a mental health problem; and (3 promotes behaviours associated with anti-stigma campaign engagement. Two mass participation social contact programmes within England’s Time to Change campaign were evaluated via a 2-part questionnaire. 403 participants completed initial questionnaires (70% paper, 30% online and 83 completed follow-up questionnaires online 4–6 weeks later. Results This study investigated the impact of social contact and whether presence of specific facilitating factors (equal status, common goals, cooperation and friendship potential: (1 improves intended stigmatising behaviour; (2 increases future willingness to disclose a mental health problem; and (3 promotes behaviours associated with anti-stigma campaign engagement. Two mass participation social contact programmes within England’s Time to Change campaign were evaluated via a 2-part questionnaire. 403 participants completed initial questionnaires (70% paper, 30% online and 83 completed follow-up questionnaires online 4–6 weeks later. Campaign events facilitated meaningful intergroup social contact between individuals with and without mental health problems. Presence of facilitating conditions

  13. TRPA1 is functionally expressed primarily by IB4-binding, non-peptidergic mouse and rat sensory neurons.

    Directory of Open Access Journals (Sweden)

    Marie E Barabas

    functionally expressed primarily in the IB4-positive, CGRP-negative subpopulation of small lumbar DRG neurons from rodents. Thus, IB4 binding is a better indicator than neuropeptides for TRPA1 expression.

  14. TRPA1 Is Functionally Expressed Primarily by IB4-Binding, Non-Peptidergic Mouse and Rat Sensory Neurons

    Science.gov (United States)

    Stucky, Cheryl L.

    2012-01-01

    primarily in the IB4-positive, CGRP-negative subpopulation of small lumbar DRG neurons from rodents. Thus, IB4 binding is a better indicator than neuropeptides for TRPA1 expression. PMID:23133534

  15. Success Factors for the Implementation of an Intended Brand Personality: Conceptual Framework and Empirical Study in the Swiss Luxury Industry

    OpenAIRE

    Hoyer, Wayne D.; Krohmer, Harley; Lobschat, Lara

    2015-01-01

    The creation and implementation of an intended brand personality has become a prevailing topic, both for practitioners and researchers. Especially in luxury industry, where brands hold a strong symbolic meaning, marketers are faced with the challenge of successfully establishing an intended brand personality and turning it into a realized brand personality among consumers. However, research identifying drivers for successful brand personality implementation is scarce. Therefore, the aim of th...

  16. Obesity risk knowledge, weight misperception and diet and health-related attitudes among women intending to become pregnant

    Science.gov (United States)

    BERENSON, Abbey B.; POHLMEIER, Ali M.; LAZ, Tabassum H.; RAHMAN, Mahbubur; SAADE, George

    2015-01-01

    Objective To evaluate obesity risk knowledge, weight misperception and diet and health-related attitudes among women intending to become pregnant compared to those not intending to become pregnant. Study Design Cross-sectional survey of health behaviors including obesity risk knowledge, weight misperception, and diet and health-related attitudes among women (16-40 years) attending reproductive health clinics in southeast Texas. Data were collected through self-administered questionnaires and chart review. Multivariable logistic regression analyses were performed to examine the association between pregnancy intention and obesity risk knowledge, weight misperception and health-related attitudes after adjusting for age, race, income and gravidity. Results Overall, 1,726 women completed the survey of which 1,420 responded to a question on pregnancy intention. Of these, 126 stated they were intending to become pregnant. Obesity risk knowledge (adjusted odds ratio [aOR] 1.14, 95% confidence interval [CI] 0.74-1.77) and weight misperception (aOR 1.17, 95% CI 0.75-1.83) did not differ between women intending and not intending to become pregnant. Additionally, diet and health-related attitudes did not differ between these two groups (P>0.05 for all). Among women intending to become pregnant, 51% had low obesity risk knowledge and 31% misperceived their body weight. Further, 76% of these women felt confused about what constitutes a healthy diet, although 47% believed that their current diet was healthy and saw no reason to change their current eating patterns. While weight misperception did not differ significantly between the two groups, overweight women intending to become pregnant were more likely to misperceive their weight than obese women intending to become pregnant (71% vs 10%, Ppregnant, regarding the risks associated with being overweight or obese, misperception of body weight, and negative diet and health-related attitudes. PMID:26099687

  17. Preparation and characterization of an acellular bovine pericardium intended for manufacture of valve bioprostheses.

    Science.gov (United States)

    Goissis, Gilberto; Giglioti, Aparecida de Fátima; Braile, Domingo Marcolino

    2011-05-01

    Major problems with biological heart valves post-implantation are associated with progressive structural deterioration and calcification attributed to glutaraldehyde processing, dead cells, and cell fragments present in the native tissue. In spite of these problems, glutaraldehyde still is the reagent of choice. The results with acellular matrix xenograft usually prepared by detergent treatment in association with enzymes are rather conflicting because while preserving mechanical properties, tissue morphology and collagen structure are process dependent. This work describes a chemical approach for the preparation of an acellular bovine pericardium matrix intended for the manufacture of heart valve bioprostheses. Cell removal was performed by an alkaline extraction in the presence of calcium salts for periods ranging from 6 to 48 h. The results showed that cell removal was achieved after 12 h, with swelling and negative charge increasing with processing time. Nevertheless, collagen fibril structure, ability to form fibrils, and stability to collagenase were progressive after 24-h processing. There was no denaturation of the collagen matrix. A process is described for the preparation of acellular bovine pericardium matrices with preserved fibril structure and morphology for the manufacture of cardiac valve bioprostheses and may be used in other applications for tissue reconstruction. © 2011, Copyright the Authors. Artificial Organs © 2011, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

  18. Water sorption properties of HM-pectin and liposomes intended to alleviate dry mouth.

    Science.gov (United States)

    Adamczak, Małgorzata I; Martinsen, Ørjan G; Smistad, Gro; Hiorth, Marianne

    2016-06-15

    Pharmaceutical formulations intended for treatment of xerostomia (dry mouth) should be able to keep the oral mucosa hydrated for a prolonged period of time. The products already existing on the market contain water-soluble polymers, however their ability to moisturize the oral mucosa for a longer period of time seems limited. In this paper the sorption properties of water vapor of high-methoxylated pectin (HM-pectin, a hydrophilic biopolymer) and phosphatidylcholine-based (Soya-PC) liposomes have been studied and compared using a gravimetric method. The kinetics of water desorption and sorption have been recorded over the relative humidity range RH=95-0-95%, at 35°C. The obtained isotherms were found to be well described by the n-layer Brunauer-Emmet-Teller (BET) adsorption model. The water isotherms on HM-pectin were Type II (IUPAC), while water isotherms on liposomes were Type III. The maximum water sorption capacity of liposomes (1.2mg water per mg of adsorbent at 95% RH) was found to be twice as high as for pectin. Due to the slower water release from the liposomes, as well as their high water sorption capacity, they seem to have great potential in relieving the symptoms of dry mouth syndrome.

  19. Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation.

    Science.gov (United States)

    Jensen, Ditte Marie Krohn; Cun, Dongmei; Maltesen, Morten Jonas; Frokjaer, Sven; Nielsen, Hanne Mørck; Foged, Camilla

    2010-02-25

    Local delivery of small interfering RNA (siRNA) to the lungs constitutes a promising new area in drug delivery. The present study evaluated parameters of importance for spray drying of siRNA-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) into nanocomposite microparticles intended for inhalation. The spray drying process was optimised using a statistical design of experiment and by evaluating powder characteristics upon systematic variation of the formulation parameters. Concentration, carbohydrate excipient (trehalose, lactose and mannitol) and the ratio of NP to excipient were varied to monitor the effects on moisture content, particle morphology, particle size and powder yield. The identified optimum conditions were applied for spray drying of siRNA-loaded nanocomposite microparticles, resulting in a product with a low water content (0.78% w/w) and an aerodynamic particle diameter considered suitable for inhalation. The use of mannitol in the formulation allowed a significantly lower moisture content than trehalose and lactose. The inclusion of 50% (w/w) or higher amounts of NPs resulted in a marked change in the surface morphology of the spray-dried particles. Importantly, the integrity and biological activity of the siRNA were preserved during the spray drying process. In conclusion, the present results show that spray drying is a suitable technique for producing nanocomposite microparticles comprising siRNA-containing PLGA NPs for potential use in inhalation therapy.

  20. Mechanical properties characterization of composite sandwich materials intended for space antenna applications

    Science.gov (United States)

    Bowles, Kenneth J.; Vannucci, Raymond D.

    1986-01-01

    The composite materials proposed for use in the Advanced Communications Technology Satellite (ACTS) Program contains a new, high modulus graphite fiber as the reinforcement. A study was conducted to measure certain mechanical properties of the new fiber-reinforced material as well as of a composite-faced aluminum honeycomb sandwich structure. Properties were measured at -157, 22, and 121 C. Complete characterization of this material was not intended. Longitudinal tensile, picture-frame shear, short-beam shear, and flexural tests were performed on specimens of the composite face-sheet materials. Unidirectional, cross-plied, and quasi-isotropic fiber composite ply layup designs were fabricated and tested. These designs had been studied by using NASA's Integrated Composite Analyzer (ICAN) computer program. Flexural tests were conducted on (+/- 60/0 deg) sub s composite-faced sandwich structure material. Resistance strain gages were used to measure strains in the tensile, picture-frame, and sandwich flexural tests. The sandwich flexural strength was limited by the core strength at -157 and 22 C. The adhesive bond strength was the limiting factor at 121 C. Adhesive mechanical properties are reflected in sandwich structure flexural properties when the span-to-depth ratio is great enough to allow a significant shear effect on the load-deflection behavior of the sandwich beam. Most measured properties agreed satisfactorily with the properties predicted by ICAN.

  1. Realizing the Intended Nationally Determined Contribution: The Role of Renewable Energies in Vietnam

    Directory of Open Access Journals (Sweden)

    Thanh Tu Tran

    2016-07-01

    Full Text Available This study contributes to the realization of intended nationally determined contributions (INDCs by analyzing their implications for the energy production system and the economy, and determines the role of renewable energies (RE in reducing the challenge of committing to the INDCs. The Asia-Pacific Integrated Model/Computable General Equilibrium (AIM/CGE model was used to assess seven scenarios having the same socioeconomic development but different shares of RE in power generation. By comparing different relative reductions caused by the emission constraints vis-a-vis the business-as-usual (BaU scenario, the mitigation costs can be estimated. Results show that the economic impact could be reduced by around 55% in terms of welfare loss (from 6.0% to 2.7% and by around 36% in terms of gross domestic product (GDP loss (from 3.4% to 2.1% through the incorporation of high levels of renewable energy. Furthermore, the additional double deployment of wind and SPV to 5.4% and 12.0%, respectively, which currently comprise 43.1% of the renewable energies used in electricity generation, could reduce the GDP loss from 2.1% to 1.9% and reduce the welfare loss from 2.7% to 1.5% in order to achieve a 25.0% GHG emissions reduction. These losses are less than those in the pricing-only scenario (2.1% and 2.3%, respectively.

  2. 2-D Circulation Control Airfoil Benchmark Experiments Intended for CFD Code Validation

    Science.gov (United States)

    Englar, Robert J.; Jones, Gregory S.; Allan, Brian G.; Lin, Johb C.

    2009-01-01

    A current NASA Research Announcement (NRA) project being conducted by Georgia Tech Research Institute (GTRI) personnel and NASA collaborators includes the development of Circulation Control (CC) blown airfoils to improve subsonic aircraft high-lift and cruise performance. The emphasis of this program is the development of CC active flow control concepts for both high-lift augmentation, drag control, and cruise efficiency. A collaboration in this project includes work by NASA research engineers, whereas CFD validation and flow physics experimental research are part of NASA s systematic approach to developing design and optimization tools for CC applications to fixed-wing aircraft. The design space for CESTOL type aircraft is focusing on geometries that depend on advanced flow control technologies that include Circulation Control aerodynamics. The ability to consistently predict advanced aircraft performance requires improvements in design tools to include these advanced concepts. Validation of these tools will be based on experimental methods applied to complex flows that go beyond conventional aircraft modeling techniques. This paper focuses on recent/ongoing benchmark high-lift experiments and CFD efforts intended to provide 2-D CFD validation data sets related to NASA s Cruise Efficient Short Take Off and Landing (CESTOL) study. Both the experimental data and related CFD predictions are discussed.

  3. Guidelines for collecting vouchers and tissues intended for genomic work (Smithsonian Institution: Botany Best Practices

    Directory of Open Access Journals (Sweden)

    Vicki Funk

    2017-01-01

    Full Text Available The introduction of Next Generation Sequencing into the disciplines of plant systematics, ecology, and metagenomics, among others, has resulted in a phenomenal increase in the collecting and storing of tissue samples and their respective vouchers. This manual suggests standard practices that will insure the quality and preservation of the tissue and vouchers and their respective data. Although written for use by the Smithsonian Institution botanists it suggests a framework for collecting tissues and vouchers that other research programs can adapt to their own needs. It includes information on collecting voucher specimens, collecting plant tissue intended for genomic analysis, how to manage these collections, and how to incorporate the data into a database management system. It also includes many useful references for collecting and processing collections. We hope it will be useful for a variety of botanists but especially those who know how to collect plants and want to collect tissue samples that will be useful for genomic research, and those who are skilled in lab work and want to know how to properly voucher and record their tissue collections.

  4. Ecotoxicologically based marine acute water quality criteria for metals intended for protection of coastal areas.

    Science.gov (United States)

    Durán, I; Beiras, R

    2013-10-01

    Acute water quality criteria (WQC) for the protection of coastal ecosystems are developed on the basis of short-term ecotoxicological data using the most sensitive life stages of representative species from the main taxa of marine water column organisms. A probabilistic approach based on species sensitivity distribution (SSD) curves has been chosen and compared to the WQC obtained applying an assessment factor to the critical toxicity values, i.e. the 'deterministic' approach. The criteria obtained from HC5 values (5th percentile of the SSD) were 1.01 μg/l for Hg, 1.39 μg/l for Cu, 3.83 μg/l for Cd, 25.3 μg/l for Pb and 8.24 μg/l for Zn. Using sensitive early life stages and very sensitive endpoints allowed calculation of WQC for marine coastal ecosystems. These probabilistic WQC, intended to protect 95% of the species in 95% of the cases, were calculated on the basis of a limited ecotoxicological dataset, avoiding the use of large and uncertain assessment factors.

  5. Fabrication and testing history prototypes and production units

    Energy Technology Data Exchange (ETDEWEB)

    1954-09-01

    From April, 1951 to Aug, 1954, New York Shipbuilding Corp. carried out a subcontract with E.I. du Pont de Nemours & Company that was without parallel in the shipyard`s history. The work, designated the NYX Project for reasons of security, was vital to the operations of the Savannah River Plant, Aiken, S.C., which was then being designed and constructed by du Pont for the Atomic Energy Commission. It consisted of three broad parts: developmental and experimental work; fabrication and testing of a prototype unit; fabrication of production units. Five production units were ultimately built, one of them converted from the prototype. All were fabricated from stainless steel, and involved welding techniques, control of thermal distortion and tolerances never previously attempted on assemblies of comparable size. Du Pont`s technical experience and the background of New York Ship in heavy construction, particularly in the fabrication of naval gun turrets, were combined from the outset to resolve the difficult fabrication problems that occurred almost daily. Representatives of both companies worked together as a team in the shops and at supervisory levels to an unprecedented extent. The report is intended primarily to summarize New York Ship`s part in the project, but also includes some of du Pont`s activities since the work of the two organizations was so interrelated. Because of the scope of the program, it will not always be possible to provide detailed information, but rather to record what happened in general terms. Where the reader desires more specific data, he should refer to original plans and records, including various reports compiled during the course of the project.

  6. Fear of childbirth and duration of labour: a study of 2206 women with intended vaginal delivery.

    Science.gov (United States)

    Adams, S S; Eberhard-Gran, M; Eskild, A

    2012-09-01

    To assess the association between fear of childbirth and duration of labour. A prospective study of women from 32 weeks of gestation through to delivery. Akershus University Hospital, Norway. A total of 2206 pregnant women with a singleton pregnancy and intended vaginal delivery during the period 2008-10. Fear of childbirth was assessed by the Wijma Delivery Expectancy Questionnaire (W-DEQ) version A at 32 weeks of gestation, and defined as a W-DEQ sum score ≥ 85. Information on labour duration, use of epidural analgesia and mode of delivery was obtained from the maternal ward electronic birth records. Labour duration in hours: from 3-4 cm cervical dilatation and three uterine contractions per 10 minutes lasting ≥ 1 minute, until delivery of the child. Fear of childbirth (W-DEQ sum score ≥ 85) was present in 7.5% (165) of women. Labour duration was significantly longer in women with fear of childbirth compared with women with no such fear using a linear regression model (crude unstandardized coefficient 1.54; 95% confidence interval 0.87-2.22, corresponding to a difference of 1 hour and 32 minutes). After adjustment for parity, counselling for pregnancy concern, epidural analgesia, labour induction, labour augmentation, emergency caesarean delivery, instrumental vaginal delivery, offspring birthweight and maternal age, the difference attenuated, but remained statistically significant (adjusted unstandardized coefficient 0.78; 95% confidence interval 0.20-1.35, corresponding to a 47-minute difference). Duration of labour was longer in women with fear of childbirth than in women without fear of childbirth. © 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.

  7. A numerical study on intended and unintended failure mechanisms in blanking of sandwich plates

    Science.gov (United States)

    Chen, L.; Soyarslan, C.; Tekkaya, A. E.

    2013-05-01

    Metal-polymer-metal sandwich plates are widely used in the automotive and aerospace industry. As for different applications the sandwich plates can be divided into two types. They are sound-damping laminates with a polymer core much thinner than the metallic faces and low-density laminates with a core thickness of approximately 40-60% of the total thickness. One frequent process step in production of parts made of these plates is the blanking process whose hereditary effects draw the limits of further forming stages or service performance and life; e.g. the failure of the adhesive in the thermoplastic polymer interface affects the sound-damping efficiency intensively. With this motivation, we present FE simulation of an axi-symmetric blanking process of steel/polyethylene/steel sound-damping laminates. The mechanical behavior of the metallic layers was characterized by finite strain rate independent elasto-plasticity where progressive material deterioration and fracture are given account for using continuum damage mechanics (CDM). This material model is made accessible via implementations as VUMAT subroutines for ABAQUS/Explicit. Possible failure of the thermoplastic polymer which may lead to delamination of the metallic layers is modeled using ABAQUS built-in cohesive zone elements. The results show that existing intended and unintended failure modes, e.g. blanking of the metallic and thermoplastic polymer constituents as well as failure of polymer layer under shear and compression, can be effectively studied with the proposed framework for process enhancement. As a future work, a damage coupled nonlinear visco-elastic constitutive model will be devised for the simulation of the thermoplastic layer in low-density laminates.

  8. ASSESSMENT OF KNOWLEDGE REGARDING FAMILY PLANNING METHODS AND INTENDED FAMILY SIZE AMONG MEN OF URBAN SLUM

    Directory of Open Access Journals (Sweden)

    Anand Mohan Dixit

    2013-12-01

    Full Text Available Objective: To assess the knowledge of contraceptive methods and intended family size among the men of urban slum.Material and Method: Present study conducted in urban slum area of Jaipur. Information from 400 married men of age group 18-49 years collected on semi structured schedule during June to October 2012.House to house survey conducted to achieve defined sample size. Data were analyzed by using SPSS 12 soft ware. Chi square, t test and ANOVA were used for interpretation.Result and Conclusion: Most commonly known methods of family planning were female sterilization (95.2%, condom (94.7% and Male sterilization (93.5%.  IUCD (57% was still not popularly known method of contraception. Emergency contraceptive pills (12.2% and Injectables (25.7% were least known methods among men. Knowledge of different contraceptive differs according to educational status and caste of men.  TV and radio were main source of information. Only 16% men said that they got information from health personnel. On analysis present family size was 3.125 while desired family size was 2.63, it shows that two child norm is not ideal to all. Men who had already two children 53 % of them still want to expand their family. Approximately half of the men feel that they have larger family size and the main reasons were inappropriate knowledge (37% and ignorance (21%. Those men who want to expand their family size, son preference was the major reason. Only 3% men show the intention of one child as ideal in family, which indicate that one child norm is too far to reach.

  9. Sexual self-concept as influencing intended sexual health behaviour of young adolescent Taiwanese girls.

    Science.gov (United States)

    Pai, Hsiang-Chu; Lee, Sheuan

    2012-07-01

    The purpose of this study was to test a process model that assesses the relationship of sexual health knowledge and normative beliefs to sexual health behavioural intention, with sexual self-concept as a mediating variable. The model is intended to assist in the prediction of which adolescents would exhibit a lower intention to engage in protective sexual health behaviour. Previous research has shown that sexual-related behaviours are associated with sexual self-concept, sexual health knowledge and perceived parental/peer approval of sexual behaviour. This study is a cross-sectional research. This study was conducted with 545 adolescent girls, aged 12-15 years, from eight junior high schools in Taiwan. Participants were assessed using the Sexual Self-Concept Inventory, the Sexual Health Behavior Intention Scale, the Parental Approval of Sexual Behavior Scale (PASB), the Friends' Approval of Sexual Behavior Scale and the Sexual Health Knowledge Scale. Data were analysed using structural equation modelling, with the maximum likelihood estimate determined by the LISREL 8.52 program. The model exhibited adequate fit (goodness-of-fit index = 0.96, adjusted goodness-of-fit index = 0.94, normed fit index = 0.96, comparative fit index = 0.98, standardised root mean square residual = 0.049 and root mean square error of approximation = 0.048) and the findings indicate that sexual self-concept was a significant influence on the relationship of sexual health knowledge and normative beliefs to sexual health behavioural intention. The results of this study revealed the importance of sexual self-concept for adolescent girls' sexual health behaviour. Evidence-based strategies that reinforce and clarify sexual self-concept as a mediating factor may aid in adolescent females' intention to engage in protective sexual health behaviour. © 2012 Blackwell Publishing Ltd.

  10. Addition of Phenols Compounds to Meat Dough Intended for Salami Manufacture and its Antioxidant Effect

    Science.gov (United States)

    Fasolato, Luca; Cardazzo, Barbara; Carraro, Lisa; Taticchi, Agnese; Balzan, Stefania

    2014-01-01

    A purified extract of phenols compounds (65% of phenolic content of which decarboxymethyl oleuropein aglycone represented 45% of the wet mass) obtained from vegetation water (a by-product of oil mill) was added to a ground meat dough intended for salami manufacture in two concentration levels: 75 and 150 mg/100 g of dough (F1 and F2, respectively). The control batch was composed of lean and fat cuts of pork in 70:30 ratio, 2.7% salt and a mixed starter culture of staphylococci and pediococci. After stuffing into natural casings, salamis were aged until they reached a total weight loss of 30%. The product was then sliced and packaged in a protective atmosphere (nitrogen:carbon dioxide 80:20) and placed in a refrigerator thermostat (2-4°C) with alternating 12 h of artificial light and darkness. The samples were analysed for the measurement of pH, water activity, organic acidity, peroxide number and secondary products of lipid peroxidation at the time of slicing and after 10, 20 and 30 days of storage into the refrigerated thermostat. The pH and water activity were not substantially different between the control and the two enriched batches. The peroxide number and secondary products of lipid peroxidation values in the two batches with phenols were at least substantially lower than the control sample. In conclusion, the phenol compounds obtained from vegetation water have shown no interference with the ripening process while protecting the dough from oxidation. PMID:27800353

  11. Addition of phenols compounds to meat dough intended for salami manufacture and its antioxidant effect

    Directory of Open Access Journals (Sweden)

    Enrico Novelli

    2014-08-01

    Full Text Available A purified extract of phenols compounds (65% of phenolic content of which decarboxymethyl oleuropein aglycone represented 45% of the wet mass obtained from vegetation water (a by-product of oil mill was added to a ground meat dough intended for salami manufacture in two concentration levels: 75 and 150 mg/100 g of dough (F1 and F2, respectively. The control batch was composed of lean and fat cuts of pork in 70:30 ratio, 2.7% salt and a mixed starter culture of staphylococci and pediococci. After stuffing into natural casings, salamis were aged until they reached a total weight loss of 30%. The product was then sliced and packaged in a protective atmosphere (nitrogen:carbon dioxide 80:20 and placed in a refrigerator thermostat (2-4°C with alternating 12 h of artificial light and darkness. The samples were analysed for the measurement of pH, water activity, organic acidity, peroxide number and secondary products of lipid peroxidation at the time of slicing and after 10, 20 and 30 days of storage into the refrigerated thermostat. The pH and water activity were not substantially different between the control and the two enriched batches. The peroxide number and secondary products of lipid peroxidation values in the two batches with phenols were at least substantially lower than the control sample. In conclusion, the phenol compounds obtained from vegetation water have shown no interference with the ripening process while protecting the dough from oxidation.

  12. Characterization of different vitamin E carriers intended for pulmonary drug delivery.

    Science.gov (United States)

    Laouini, A; Andrieu, V; Vecellio, L; Fessi, H; Charcosset, C

    2014-08-25

    The targeted release of drugs intended for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. Liquid dispersions encapsulating vitamin E (liposomes, micelles, nano-emulsion, and solid lipid particles) were prepared using various methods based on membrane contactor. The dispersions were nebulized and aerodynamic characteristics of the generated aerosols were assessed using two different methods: laser light scattering and cascade impaction. When the laser diffraction technique was used, results showed that fine particle fractions (<5 μm) were 19, 29, 38 and 71% for solid lipid particles, micelles, nano-emulsion and liposomes, respectively. When the impaction method was applied, using a next generation pharmaceutical impactor operated at 30 l/min, results showed that fine particle fractions were 39, 78, 82 and 87% for solid lipid particles, micelles, nano-emulsion and liposomes, respectively. The differences observed between the results obtained from both methods confirm that the laser diffraction method is not always suitable for aerodynamic characterization of aerosols and should be validated against an impaction method. Nebulization of the drug-carrier systems led to an increase of their size most likely due to aggregation phenomena. The size was increased by a factor of 2-26 depending on the encapsulation system. The most important aggregation was obtained with nano-emulsion; the less one with solid lipid particles. The mass median aerodynamic diameter (MMAD) of the generated aerosols ranged from 1.76 to 6.10 μm. The application of a mathematical model, the Multiple-Path Particle Dosimetry (MPPD), for the prediction of the pulmonary deposit gave encouraging results. The rate of vitamin E able to reach the lung ranged from 37.6 (for the liposomes) to 51.6% (for the micelles). The obtained results showed that the different systems developed for vitamin E encapsulation were suitable to

  13. Multifunctional coating MAI D5 intended for the protection of refractory materials

    Science.gov (United States)

    Zhestkov, B. E.; Terent'eva, V. S.

    2010-01-01

    A thin-layer heterophase MAI D5 coating intended for the protection of carbon-containing composite materials (C-C-, C-SiC-, SiC-SiC-composite material) and refractory metal-based alloys against high-temperature gas corrosion and erosion is tested. The coating is formed from a specially developed Si-Ti-Mo-B-Y microcomposition powder material. A new approach to creating self-healing heterophase coatings is used. At operating temperatures, the structure and phase composition of the MAI D5 coating provides rapid self-healing of random defects on the coating surface and in the base material owing to the presence of a silicon-containing eutectic, which favors rapid recovery of a protective amorphous silica layer consumed during operation. Under operating conditions, the coating undergoes self-organization to form a multilayer system with a number of functional oxide micro-, submicro-, and nanolayers. Samples with the MAI D5 coating are subjected to combined tests on bench plants located at MAI and TsAGI under conditions emulating the re-entry of a hypersonic aircraft, when its surface temperature reaches 2400 K. Certification tests are performed in wind tunnels located at TsAGI during a simultaneous action of a hypersonic dissociated-air flow and mechanical loads. The protection of heat-loaded structural elements in space vehicles made of ultrahigh-temperature materials against high-temperature gas corrosion and erosion by the MAI D5 coating in hypersonic dissociated-air flows is shown to be efficient.

  14. Termite mound emissions of CH4 and CO2 are primarily determined by seasonal changes in termite biomass and behaviour.

    Science.gov (United States)

    Jamali, Hizbullah; Livesley, Stephen J; Dawes, Tracy Z; Hutley, Lindsay B; Arndt, Stefan K

    2011-10-01

    Termites are a highly uncertain component in the global source budgets of CH(4) and CO(2). Large seasonal variations in termite mound fluxes of CH(4) and CO(2) have been reported in tropical savannas but the reason for this is largely unknown. This paper investigated the processes that govern these seasonal variations in CH(4) and CO(2) fluxes from the mounds of Microcerotermes nervosus Hill (Termitidae), a common termite species in Australian tropical savannas. Fluxes of CH(4) and CO(2) of termite mounds were 3.5-fold greater in the wet season as compared to the dry season and were a direct function of termite biomass. Termite biomass in mound samples was tenfold greater in the wet season compared to the dry season. When expressed per unit termite biomass, termite fluxes were only 1.2 (CH(4)) and 1.4 (CO(2))-fold greater in the wet season as compared to the dry season and could not explain the large seasonal variations in mound fluxes of CH(4) and CO(2). Seasonal variation in both gas diffusivity through mound walls and CH(4) oxidation by mound material was negligible. These results highlight for the first time that seasonal termite population dynamics are the main driver for the observed seasonal differences in mound fluxes of CH(4) and CO(2). These findings highlight the need to combine measurements of gas fluxes from termite mounds with detailed studies of termite population dynamics to reduce the uncertainty in quantifying seasonal variations in termite mound fluxes of CH(4) and CO(2).

  15. INVESTIGATION OF INTENDED SERVICE QUALITY LEVELS IN HEALTH-FITNESS CENTERS IN TURKEY

    Directory of Open Access Journals (Sweden)

    Aydoğan

    2015-01-01

    Full Text Available The aim of the study was to evaluate the quality of services in health-fitness centers a medium-sized city that located in Central Anatolia Region in Turkey. In this study, assessments of the levels of service perceived and expected by the customers under four different dimensions (staff, programme, locker rooms and facility were carried out in order to identify the levels of fitness centers in terms of service quality. The replies provided by 219 members of fitness center who filled out the scale form voluntarily and without skipping any parts were evaluated. In order to measure the service quality of fitness in the study, Service Quality Assessment Scale (SQAS, which was developed by Lam et al. (2005 and whose Turkish adaptation was done by Gürbüz et al. (2005, was used. The SQAS was composed of 4 dimensions (staff, programme, locker rooms and facility and 34 items. In assessing the service quality, Gap Model (Parasuraman, Zeithaml and Berry, 1988 was used; though this method, the gaps were identified by subtracting perception scores from expectation scores. In order to find the differences between the groups, “Paired-Samples "t" test”, “Independent Samples "t" test” and “One way ANOVA” were utilized. When the results obtained and the differences between perception and expectation scores were assessed in terms of dimensions, it was observed that all dimensions had a negative difference. In terms of statistics, it was discovered that there was a meaningful difference in all of staff, programme, locker rooms and facility at the level of p<0,05. Among those, the lowest level of quality was observed to belong to “programme” dimension with the unit of -0,564. Later, with the -0,509-unit difference “locker rooms” dimension, with the -0,487-unit difference “staff” dimension and with the -0,481-unit difference “facility” dimension follow respectively. When it was evaluated according to demographic aspect in the study, it

  16. Introduction to Crop Production. Unit A-7.

    Science.gov (United States)

    Luft, Vernon D.; Backlund, Paul

    This document is a teacher's guide for a unit in vocational agriculture for college freshmen. It is intended to be used for 20 hours of instruction as an introductory course on the crop industry. It provides a broad background of the industry, including production, marketing, processing, and transportation, with emphasis on identifying major crops…

  17. AIDS Pandemic in the United States

    Science.gov (United States)

    Erickson, Amy H.; Melendez, Barbra S.; Ball, Daniel L.; Morse, Steven T.; Phillips, Geoffrey P.

    2010-01-01

    This project is one of four that were issued to first semester sophomore undergraduates at the United States Military Academy as part of an integrated learning experience at the end of their Calculus II course work. This project was used during a short, seven lesson block of instruction that was intended to capitalize on their recent academic…

  18. Identification of multiple serine to asparagine sequence variation sites in an intended copy product of LUCENTIS® by mass spectrometry.

    Science.gov (United States)

    Griaud, François; Winter, Andrej; Denefeld, Blandine; Lang, Manuel; Hensinger, Héloïse; Straube, Frank; Sackewitz, Mirko; Berg, Matthias

    2017-08-28

    Patent expiration of first-generation biological and the high cost of innovative biological are 2 drivers for the development of biosimilar products. There are, however, technical challenges to the production of exact copies of such large molecules. In this study, we performed a head-to-head comparison between the originator anti-VEGF-A Fab product LUCENTIS® (ranibizumab) and an intended copy product using an integrated analytical approach. While no differences could be observed using size-exclusion chromatography, capillary electrophoresis-sodium dodecyl sulfate and potency assays, different acidic peaks were identified with cation ion exchange chromatography and capillary zone electrophoresis. Further investigation of the intact Fab, subunits and primary sequence with mass spectrometry demonstrated the presence of a modified light chain variant in the intended copy product batches. This variant was characterized with a mass increase of 27.01 Da compared with the originator sequence and its abundance was estimated in the range of 6-9% of the intended copy product light chain. MS/MS spectra interrogation confirmed that this modification relates to a serine to asparagine sequence variant found in the intended copy product light chain. We demonstrated that the integration of high-resolution and sensitive orthogonal technologies was beneficial to assess the similarity of an originator and an intended copy product.

  19. Are individuals with disabilities and their families "resilient"? Deconstructing and recasting a well-intended concept.

    Science.gov (United States)

    Hutcheon, Emily J; Lashewicz, Bonnie

    2015-01-01

    This article contributes to existing scholarship related to resilience in families with members with disabilities by first using a disability studies orientation to "unbound" existing definitions of resilience, then by providing empirical illustration of this unbounding. Using family as our unit of analysis, we present data from 3 families who navigate successes and challenges related to disability. Three themes of honoring relationships, family member expertise, and standing in one's power emerged. We suggest that more nuanced understandings of resilience, which account for fluid, localized perspectives and encompass contradictory meanings and processes (e.g., stress and joy), have implications for policy and practice.

  20. Uterine rupture by intended mode of delivery in the UK: a national case-control study.

    Directory of Open Access Journals (Sweden)

    Kathryn E Fitzpatrick

    Full Text Available BACKGROUND: Recent reports of the risk of morbidity due to uterine rupture are thought to have contributed in some countries to a decrease in the number of women attempting a vaginal birth after caesarean section. The aims of this study were to estimate the incidence of true uterine rupture in the UK and to investigate and quantify the associated risk factors and outcomes, on the basis of intended mode of delivery. METHODS AND FINDINGS: A UK national case-control study was undertaken between April 2009 and April 2010. The participants comprised 159 women with uterine rupture and 448 control women with a previous caesarean delivery. The estimated incidence of uterine rupture was 0.2 per 1,000 maternities overall; 2.1 and 0.3 per 1,000 maternities in women with a previous caesarean delivery planning vaginal or elective caesarean delivery, respectively. Amongst women with a previous caesarean delivery, odds of rupture were also increased in women who had ≥ two previous caesarean deliveries (adjusted odds ratio [aOR] 3.02, 95% CI 1.16-7.85 and <12 months since their last caesarean delivery (aOR 3.12, 95% CI 1.62-6.02. A higher risk of rupture with labour induction and oxytocin use was apparent (aOR 3.92, 95% CI 1.00-15.33. Two women with uterine rupture died (case fatality 1.3%, 95% CI 0.2-4.5%. There were 18 perinatal deaths associated with uterine rupture among 145 infants (perinatal mortality 124 per 1,000 total births, 95% CI 75-189. CONCLUSIONS: Although uterine rupture is associated with significant mortality and morbidity, even amongst women with a previous caesarean section planning a vaginal delivery, it is a rare occurrence. For women with a previous caesarean section, risk of uterine rupture increases with number of previous caesarean deliveries, a short interval since the last caesarean section, and labour induction and/or augmentation. These factors should be considered when counselling and managing the labour of women with a previous

  1. Hemorrhage in mouse tumors induced by dodecaborate cluster lipids intended for boron neutron capture therapy

    Directory of Open Access Journals (Sweden)

    Schaffran T

    2014-07-01

    Full Text Available Tanja Schaffran,1 Nan Jiang,1 Markus Bergmann,2,3 Ekkehard Küstermann,4 Regine Süss,5 Rolf Schubert,5 Franz M Wagner,6 Doaa Awad,7 Detlef Gabel1,2,8 1Department of Chemistry, University of Bremen, 2Institute of Neuropathology, Klinikum Bremen-Mitte; 3Cooperative Center Medicine, University of Bremen, 4“In-vivo-MR” AG, FB2, University of Bremen, Bremen, 5Pharmaceutical Technology, University of Freiburg, Freiburg im Breisgau, 6Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II, Technische Unversitaet Muenchen, Garching, Germany; 7Department of Biochemistry, Alexandria University, Alexandria, Egypt; 8School of Engineering and Science, Jacobs University Bremen, Bremen, Germany Abstract: The potential of boron-containing lipids with three different structures, which were intended for use in boron neutron capture therapy, was investigated. All three types of boron lipids contained the anionic dodecaborate cluster as the headgroup. Their effects on two different tumor models in mice following intravenous injection were tested; for this, liposomes with boron lipid, distearoyl phosphatidylcholine, and cholesterol as helper lipids, and containing a polyethylene glycol lipid for steric protection, were administered intravenously into tumor-bearing mice (C3H mice for SCCVII squamous cell carcinoma and BALB/c mice for CT26/WT colon carcinoma. With the exception of one lipid (B-THF-14, the lipids were well tolerated, and no other animal was lost due to systemic toxicity. The lipid which led to death was not found to be much more toxic in cell culture than the other boron lipids. All of the lipids that were well tolerated showed hemorrhage in both tumor models within a few hours after administration. The hemorrhage could be seen by in vivo magnetic resonance and histology, and was found to occur within a few hours. The degree of hemorrhage depended on the amount of boron administered and on the tumor model. The observed unwanted effect of the lipids

  2. Diode laser based photoacoustic gas measuring instruments intended for medical research

    Science.gov (United States)

    Szabó, Anna; Mohácsi, Árpád; Novák, Péter; Aladzic, Daniela; Turzó, Kinga; Rakonczay, Zoltán; Erős, Gábor; Boros, Mihály; Nagy, Katalin; Szabó, Gábor

    2012-06-01

    Analysis of breath and gases emanated from skin can be used for early and non-invasive diagnosis of various kinds of diseases. Two portable, compact, photoacoustic spectroscopy based trace gas sensors were developed for the detection of methane emanated from skin and ammonia emanated from oral cavity. The light sources were distributed feedback diode lasers emitting at the absorption lines of ammonia and methane, at 1.53 μm and 1.65 μm, respectively. Photoacoustic method ensures high selectivity, therefore cross-sensitivity was negligible even with large amount of water vapor and carbon dioxide in the gas sample. In case of ammonia a preconcentration unit was used to achieve lower minimum detectable concentration. Gas sample from the oral cavity was drawn through a glass tube to the preconcentration unit that chemically bonded ammonia and released it when heated. The minimum detectable concentration of ammonia was 10 ppb for 15 s gas sampling time (gas sample of 250 cm3). For methane minimum detectable concentration of 0.25 ppm was found with 12 s integration time, and it was proved to be adequate for the detection of methane emanated from human skin and from mice. Instruments measuring methane and ammonia are currently installed at two medical research laboratories at University of Szeged and tested as instruments for non-invasive clinical trials. The aim of the measurements is to determine correlations between diseases or metabolic processes and emanated gases.

  3. Researching Theatrical Dance. A Guide to Basic Collections, Bibliographies, Reference Books, Serials, Historical Surveys, Manuals, Special Studies, Films, Addresses, and Other Essentials; Primarily as Related to Theatrical Dance.

    Science.gov (United States)

    Pease, Edward

    Intended for dance teachers, dance students, scholars from other fields, and novice researchers, this handbook comprises a brief discussion of research methods, especially as applied to short-term student projects, and an extensive annotated bibliography on the history of theatrical dance. The bibliography is divided into 20 sections, each listing…

  4. Predicting successful intended vaginal delivery after previous caesarean section : external validation of two predictive models in a Dutch nationwide registration-based cohort with a high intended vaginal delivery rate

    NARCIS (Netherlands)

    Schoorel, E. N. C.; Melman, S.; van Kuijk, S. M. J.; Grobman, W. A.; Kwee, A.; Mol, B. W. J.; Nijhuis, J. G.; Smits, L. J. M.; Aardenburg, R.; de Boer, K.; Delemarre, F. M. C.; van Dooren, I. M.; Franssen, M. T. M.; Kleiverda, G.; Kaplan, M.; Kuppens, S. M. I.; Lim, F. T. H.; Sikkema, J. M.; Smid-Koopman, E.; Visser, H.; Vrouenraets, F. P. J. M.; Woiski, M.; Hermens, R. P. M. G.; Scheepers, H. C. J.

    2014-01-01

    ObjectiveTo externally validate two models from the USA (entry-to-care [ETC] and close-to-delivery [CTD]) that predict successful intended vaginal birth after caesarean (VBAC) for the Dutch population. DesignA nationwide registration-based cohort study. SettingSeventeen hospitals in the Netherlands.

  5. 77 FR 29701 - Impact of Construction (Under a Combined License) of New Nuclear Power Plant Units on Operating...

    Science.gov (United States)

    2012-05-18

    ... a Combined License) of New Nuclear Power Plant Units on Operating Units at Multi-Unit Sites AGENCY... a COL intending to construct and operate new nuclear power plants (NPPs) on multi-unit sites to... Impacts of Construction (under a Combined License) of New Nuclear Power Plants on Operating Units at...

  6. Assessment of an active liquid cooling garment intended for use in a hot environment.

    Science.gov (United States)

    Bartkowiak, Grazyna; Dabrowska, Anna; Marszalek, Anna

    2017-01-01

    This paper discusses the construction of a designed active liquid cooling garment (LCG) that has been developed in order to reduce thermal discomfort of persons working in hot environments. It consists of clothing with a tube system distributing a cooling liquid, a sensor measuring the microclimate under the clothing, and a portable cooling unit with a module controlling the temperature of the cooling liquid depending on the microclimate temperature under the clothing. The LCG was validated through tests on volunteers in a climatic chamber at 30 °C, a relative humidity of 40%, and an air movement rate of 0.4 m/s. The obtained test results confirmed the beneficial effects of the cooling system used on mean weighted skin temperature, the physical parameters of the microclimate under the clothing, and the participants' subjective assessments, as well as confirmed that the functioning of the control system regulating liquid temperature in the LCG was correct.

  7. Growing Up Black: A Black Literature Unit For Schools

    Science.gov (United States)

    Massenburg, Doris O.; Applebury, Bruce C.

    1971-01-01

    This literature-based unit is intended to examine the prevalent black moods, conflicts, alienations and disillusionments which accompany the present era. Literature selections include works by both black and white writers. At the end of the unit, the student will be able to realize the man, from what literature has stamped as substantial accounts…

  8. United States’ Interests in the Horn of Africa.

    Science.gov (United States)

    1986-04-23

    while Haile Selassie intended to ensure that the United States had a vested interest in the survival of his regime. "There was never an alliance between...company; and he sent troops to fight in Korea. Emperor Haile Selassie’s political manuevering achieved the establishment of a United States vested

  9. Careers (A Course of Study). Unit IX: Change Making.

    Science.gov (United States)

    Turley, Kay

    Designed to improve the change making skills of the special needs student, this set of activities on coin identification, how to make change, the dollar bill, and figuring change is the final unit of a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world of…

  10. Careers (A Course of Study). Unit III: Do It Right!

    Science.gov (United States)

    Turley, Kay

    Designed to enable the special needs student to comprehend and complete job application forms, this set of activities on job application vocabulary, neatness, and following directions is the third unit in a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the…

  11. Careers (A Course of Study). Unit I: Self Inventory.

    Science.gov (United States)

    Turley, Kay

    Designed to help special needs students develop an awareness of their own individual characteristics, values, interests, aptitudes, abilities, and personality, this self-inventory is the first unit in a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world…

  12. Native American Career Education Unit. From Idea to Product.

    Science.gov (United States)

    Far West Lab. for Educational Research and Development, San Francisco, CA.

    One of twelve instructional units in the Native American Career Education (NACE) program, this unit is intended to help Indian junior high school students understand the steps involved in making a product. Focus is on the subject areas of economics, lumber and furniture industries, and woodworking. The first two activities concern the nature of…

  13. Why intended business model innovation fails to deliver: Insights from a longitudinal study in the German smart energy market

    DEFF Research Database (Denmark)

    Sebastian, Knab; Rohrbeck, René

    This paper aims to explore whether intended business model innovation (BMI) activities enhance exploration capabilities of incumbent firms. We report findings from a longitudinal study that spans from 2010 to 2014. We find that even though incumbent firms generated 21 generic business models...

  14. 13 CFR 123.9 - What happens if I don't use loan proceeds for the intended purpose?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What happens if I don't use loan proceeds for the intended purpose? 123.9 Section 123.9 Business Credit and Assistance SMALL BUSINESS.... Any failure to respond in time will be considered an admission that you misapplied the proceeds....

  15. Assessing Students' Opportunity to Learn the Intended Curriculum Using an Online Teacher Log: Initial Validity Evidence

    Science.gov (United States)

    Kurz, Alexander; Elliott, Stephen N.; Kettler, Ryan J.; Yel, Nedim

    2014-01-01

    This study provides initial evidence supporting intended score interpretations for the purpose of assessing opportunity to learn (OTL) via an online teacher log. MyiLOGS yields 5 scores related to instructional time, content, and quality. Based on data from 46 middle school classes, the evidence indicated that (a) MyiLOGS has high usability, (b)…

  16. 75 FR 71133 - Guidance for Industry: The Safety of Imported Traditional Pottery Intended for Use With Food and...

    Science.gov (United States)

    2010-11-22

    ... HUMAN SERVICES Food and Drug Administration Guidance for Industry: The Safety of Imported Traditional... guidance entitled ``The Safety of Imported Traditional Pottery Intended for Use With Food and the Use of... traditional pottery, and labeling considerations for food use and non food use pottery that may contain lead...

  17. A Comparative Analysis of the Intended Curriculum and Its Presentation in 10th Grade Chemistry Textbooks from Seven Arabic Countries

    Science.gov (United States)

    Khaddoor, Rouba; Al-Amoush, Siham; Eilks, Ingo

    2017-01-01

    This study investigates the nature of intended secondary chemistry curricula, as they are represented by chemistry textbooks, from seven Arabic countries: Algeria, Egypt, Jordan, Kuwait, Palestine, Saudi Arabia and Syria. The curricula are evaluated through analysis of the officially approved 10th grade chemistry textbooks used nationwide in all…

  18. 40 CFR 152.10 - Products that are not pesticides because they are not intended for a pesticidal purpose.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Products that are not pesticides... ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES General Provisions § 152.10 Products that are not pesticides because they are not intended for...

  19. 16 CFR Figure 5 to Part 1203 - Location of Tesr Lines for Helmets Intended for Persons Ages 1 and Older

    Science.gov (United States)

    2010-01-01

    ... for Persons Ages 1 and Older 5 Figure 5 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Fig. 5 Figure 5 to Part 1203—Location of Tesr Lines for Helmets Intended for Persons Ages 1 and Older...

  20. Video Cases in Teacher Education: A review study on intended and achieved learning objectives by video cases

    NARCIS (Netherlands)

    Geerts, Walter; Van der Werff, Anne; Hummel, Hans; Van Geert, Paul

    2014-01-01

    This literature review focuses on the use of video cases in the education of preservice teachers as a means of achieving higher order learning objectives that are necessary for gaining situated knowledge. An overview of both intended and achieved learning objectives in relevant studies involving

  1. Video Cases in Teacher Education: A review study on intended and achieved learning objectives by video cases

    NARCIS (Netherlands)

    Geerts, Walter; Van der Werff, Anne; Hummel, Hans; Van Geert, Paul

    2014-01-01

    This literature review focuses on the use of video cases in the education of preservice teachers as a means of achieving higher order learning objectives that are necessary for gaining situated knowledge. An overview of both intended and achieved learning objectives in relevant studies involving the

  2. What Type of Teachers Do We Intend to Train? An Analysis of Teacher Profiles in MERCOSUR Curricula

    Science.gov (United States)

    Alliaud, Andrea; Feeney, Silvina María

    2015-01-01

    Over the last decades, teachers have often been identified as 'key' players for the improvement of education systems. The successive waves of reform taking place in Latin America since the 1990s have aimed at initial and continuous teacher training. The main changes intended to improve the quality and lengthen the duration of initial teacher…

  3. Traces of Teaching Methods in a Language Class and the Relationship between Teachers' Intended Learning Outcomes and Students' Uptake

    Science.gov (United States)

    Mahmoudabadi, Zahra

    2017-01-01

    This study has two main objectives: first, to find traces of teaching methods in a language class and second, to study the relationship between intended learning outcomes and uptake, which is defined as what students claim to have learned. In order to identify the teaching method, after five sessions of observation, class activities and procedures…

  4. 21 CFR 1240.61 - Mandatory pasteurization for all milk and milk products in final package form intended for direct...

    Science.gov (United States)

    2010-04-01

    ... pasteurization for all milk and milk products in final package form intended for direct human consumption. (a) No... for sale or other distribution after shipment in interstate commerce any milk or milk product in final... ingredients (milk or milk products) that have all been pasteurized, except where alternative procedures...

  5. 23 CFR 636.505 - Must a contracting agency establish a competitive range if it intends to have discussions with...

    Science.gov (United States)

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Must a contracting agency establish a competitive range if it intends to have discussions with offerors? 636.505 Section 636.505 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD...

  6. 49 CFR 178.276 - Requirements for the design, construction, inspection and testing of portable tanks intended for...

    Science.gov (United States)

    2010-10-01

    ... be provided to prevent any dangerous pressure from developing in the insulating layer in the event of... three mutually independent shut-off devices in series: the first being an internal stop-valve, excess... pipe. (4) For filling and discharge openings located below the liquid level of portable tanks intended...

  7. Generating Units

    Data.gov (United States)

    Department of Homeland Security — Generating Units are any combination of physically connected generators, reactors, boilers, combustion turbines, and other prime movers operated together to produce...

  8. Preclinical evaluation of a Haemophilus influenzae type b conjugate vaccine process intended for technology transfer.

    Science.gov (United States)

    Hamidi, Ahd; Verdijk, Pauline; Kreeftenberg, Hans

    2014-01-01

    Introduction of Haemophilus influenzae type b (Hib) vaccine in low- and middle-income countries has been limited by cost and availability of Hib conjugate vaccines for a long time. It was previously recognized by the Institute for Translational Vaccinology (Intravacc, originating from the former Vaccinology Unit of the National Institute of Public Health [RIVM] and the Netherlands Vaccine Institute [NVI]) that local production of a Hib conjugate vaccine would increase the affordability and sustainability of the vaccine and thereby help to speed up Hib introduction in these countries. A new affordable and a non-infringing production process for a Hib conjugate vaccine was developed, including relevant quality control tests, and the technology was transferred to a number of vaccine manufacturers in India, Indonesia, and China. As part of the Hib technology transfer project managed by Intravacc, a preclinical toxicity study was conducted in the Netherlands to test the safety and immunogenicity of this new Hib conjugate vaccine. The data generated by this study were used by the technology transfer partners to accelerate the clinical development of the new Hib conjugate vaccine. A repeated dose toxicity and local tolerance study in rats was performed to assess the reactogenicity and immunogenicity of a new Hib conjugate vaccine compared to a licensed vaccine. The results showed that the vaccine was well tolerated and immunogenic in rats, no major differences in both safety and immunogenicity in rats were found between the vaccine produced according to the production process developed by Intravacc and the licensed one. Rats may be useful to verify the immunogenicity of Hib conjugate vaccines and for preclinical evaluation. In general, nonclinical evaluation of the new Hib conjugate vaccine, including this proof of concept (safety and immunogenicity study in rats), made it possible for technology transfer partners, having implemented the original process with no changes

  9. Nanoparticles affect PCR primarily via surface interactions with PCR components: using amino-modified silica-coated magnetic nanoparticles as a main model

    Science.gov (United States)

    Nanomaterials have been widely reported to affect the polymerase chain reaction (PCR). However, many studies in which these effects were observed were not comprehensive, and many of the proposed mechanisms have been primarily speculative. In this work, we used amino-modified silica-coated magnetic n...

  10. UNIT, TIBET.

    Science.gov (United States)

    Louisiana Arts and Science Center, Baton Rouge.

    THE UNIT OF STUDY DESCRIBED IN THIS BOOKLET DEALS WITH THE GEOGRAPHY AND HISTORY OF TIBET. THE UNIT COVERS SOME OF THE GENERAL FEATURES OF THE COUNTRY AND THEIR EFFECT UPON THE LIVES OF THE TIBETAN PEOPLE. DISCUSSION QUESTIONS ARE INSERTED TO STIMULATE THOUGHT. THE RELIGION OF TIBET IS DISCUSSED IN RELATION TO ITS INFLUENCE ON THE ART AND CULTURE…

  11. Beef Cattle Production. An Instructional Unit for Teachers of Adult Vocational Education in Agriculture.

    Science.gov (United States)

    Metzger, Bruce; Iverson, Maynard J.

    The unit on beef cattle production is designed primarily for the adult farmer program in Kentucky as an aid to making the beef enterprise more profitable. It is aimed primarily at the commercial producer. The lessons center on some of the more important economic points in beef cattle production. Ten lessons comprise the unit, which can be adapted…

  12. Professional Knowledge and Skills Required for Accounting Majors Who Intend to Become Auditors: Perceptions of External Auditors

    OpenAIRE

    Ali Uyar; Ali Haydar Gungormus

    2011-01-01

    This research aims to ascertain the professional knowledge and the skills/attributes that are considered important by external auditors for a graduate who intends to be an auditor. For this purpose, we conducted a survey on external auditors in Turkey. The research has two dimensions: skills dimension (twenty one items) and professional knowledge dimension (twenty four items). The results indicated that all skills except “knowledge of accounting software” are perceived to be important or very...

  13. Intended long term performances of cementitious engineered barriers for future storage and disposal facilities for radioactive wastes in Romania

    OpenAIRE

    Sociu F.; Georgescu R.; Toma R.; Barariu Gh.; Fako R.

    2013-01-01

    Considering the EU statements, Romania is engaged to endorse in the near future the IAEA relevant publications on geological repository (CNCANa), to update the Medium and Long Term National Strategy for Safe Management of Radioactive Waste and to approve the Road Map for Geological Repository Development. Currently, for example, spent fuel is wet stored for 6 years and after this period it is transported to dry storage in MACSTOR-200 (a concrete monolithic module) where it is intended to rema...

  14. Studying the intended uses of the social networks by the students of the department of physical education and sport

    Directory of Open Access Journals (Sweden)

    Eynur Baybars Recep

    2017-01-01

    Full Text Available The objective of this research is to study the intended uses of the social networks by the students of the Department of Physical Education and Sport (DPES. A total of 407 DPES students have been participated into the research; 25,6% of them were women and 74.4% were men. The data collection tool used for the study was the Scale for the Intended Uses of the Social Networks. With regard to the research statistics, the independent variable t-test and ANOVA have been used; and in order to evaluate the diversity of the subgroups, Bonferroni and Tamhane (α=0,05 have been used. The analysis has revealed that on the basis of the social networking sites for which the males show a higher usage tendency according to the gender variable (p0,05. It has been seen that the Twitter users show a higher tendency in terms of the research and content subdimensions (p<0,05; and that the Instagram and other social network users show a higher tendency in terms of keeping in touch and content sharing (p<0,05. The research has revealed that the intended social network uses by the students arises mostly from the social network services, besides certain cultural influence.

  15. Correlates of HPV vaccination among adolescent females from Appalachia and reasons why their parents do not intend to vaccinate.

    Science.gov (United States)

    Reiter, Paul L; Katz, Mira L; Paskett, Electra D

    2013-06-28

    Limited research has examined HPV vaccination in Appalachia, a region with cervical cancer disparities. We analyzed 2008-2010 National Immunization Survey-Teen data for adolescent females ages 13-17 from Appalachia (n=1951) to identify correlates of HPV vaccination and reasons why their parents do not intend to vaccinate. HPV vaccine initiation was 40.8%, completion was 27.7%, and follow-through was 67.8%. Vaccination outcomes tended to be higher among females who were older, had visited their healthcare provider in the last year, or whose parents reported receiving a provider recommendation to vaccinate. Only 41.0% of parents with unvaccinated daughters intended to vaccinate in the next year. The most common reasons for not intending to vaccinate were believing vaccination is not needed or not necessary (21.5%) and lack of knowledge (18.5%). Efforts to reduce missed opportunities for vaccination at healthcare visits and address reasons why parents are not vaccinating may help increase HPV vaccination in Appalachia.

  16. Surveillance for waterborne disease and outbreaks associated with drinking water and water not intended for drinking-United States, 2005-2006

    Science.gov (United States)

    PROBLEM/CONDITION: Since 1971, CDC, the U.S. Environmental Protection Agency (EPA), and the Council of State and Territorial Epidemiologists have maintained a collaborative Waterborne Disease and Outbreak Surveillance System (WBDOSS) for collecting and reporting data related to o...

  17. The effects of {gamma}-radiation on model vitreous wasteforms intended for the disposal of intermediate and high level radioactive wastes in the United Kingdom

    Energy Technology Data Exchange (ETDEWEB)

    McGann, O.J.; Bingham, P.A.; Hand, R.J.; Gandy, A.S. [Immobilisation Science Laboratory, Department of Materials Science and Engineering, University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD (United Kingdom); Kavcic, M.; Zitnik, M.; Bucar, K. [J. Stefan Institute, Jamova 39, SI-1000 Ljubljana (Slovenia); Edge, R. [Dalton Cumbrian Facility, University of Manchester, Westlakes Science and Technology Park, Moor Row, Cumbria CA24 3HA (United Kingdom); Hyatt, N.C., E-mail: n.c.hyatt@sheffield.ac.uk [Immobilisation Science Laboratory, Department of Materials Science and Engineering, University of Sheffield, Sir Robert Hadfield Building, Mappin Street, Sheffield S1 3JD (United Kingdom)

    2012-10-15

    The effect of {gamma}-radiation on a variety of model vitreous wasteforms applied to, or conceived for, immobilisation of UK intermediate and high level radioactive wastes was studied up to a dose of 8 MGy. It was determined that {gamma}-irradiation up to this dose had no significant effect upon the mechanical properties of the wasteforms and there was no evidence of residual structural defects. FTIR and Raman spectroscopy showed no evidence of radiation directly affecting the silicate network of the glasses. The negligible impact of this {gamma}-irradiation dose on the physical properties of the glass was attributed to the presence of multivalent ions, particularly Fe, and a mechanism by which the electron-hole pairs generated by {gamma}-irradiation were annihilated by the Fe{sup 2+}-Fe{sup 3+} redox mechanism. However, reduction of sulphur species in response to {gamma}-radiation was demonstrated by S K-edge XANES and XES data.

  18. Turnley Unit

    Data.gov (United States)

    Federal Laboratory Consortium — Facilities at this unit include cattle working pens, hydraulic squeeze chute and electronic scale, a maintenance building, and four hay storage sheds. There is one...

  19. Operable Units

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset consists of operable unit data from multiple Superfund sites in U.S. EPA Region 8. These data were acquired from multiple sources at different times and...

  20. Detector Unit

    CERN Multimedia

    1960-01-01

    Original detector unit of the Instituut voor Kernfysisch Onderzoek (IKO) BOL project. This detector unit shows that silicon detectors for nuclear physics particle detection were already developed and in use in the 1960's in Amsterdam. Also the idea of putting 'strips' onto the silicon for high spatial resolution of a particle's impact on the detector were implemented in the BOL project which used 64 of these detector units. The IKO BOL project with its silicon particle detectors was designed, built and operated from 1965 to roughly 1977. Detector Unit of the BOL project: These detectors, notably the ‘checkerboard detector’, were developed during the years 1964-1968 in Amsterdam, The Netherlands, by the Natuurkundig Laboratorium of the N.V. Philips Gloeilampen Fabrieken. This was done in close collaboration with the Instituut voor Kernfysisch Onderzoek (IKO) where the read-out electronics for their use in the BOL Project was developed and produced.

  1. Interferon-gamma and tumor necrosis factor-alpha sensitize primarily resistant human endometrial stromal cells to Fas-mediated apoptosis

    DEFF Research Database (Denmark)

    Fluhr, Herbert; Krenzer, Stefanie; Stein, Gerburg M

    2007-01-01

    -mediated signaling during early implantation. Here we show that ESCs are primarily resistant to Fas-mediated apoptosis independently of their state of hormonal differentiation. Pre-treatment of ESCs with interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha sensitizes them to become apoptotic upon stimulation......-inhibitory protein (FLIP, CFLAR) expression in ESCs. Additionally, we observed an activation of caspase 3, caspase 8 and caspase 9 upon apoptotic Fas triggering. In summary, we demonstrate that IFN-gamma and TNF-alpha sensitize primarily apoptosis-resistant ESCs to Fas-mediated cell death. This might be due...... to an upregulation of Fas expression, and apoptosis seems to be mediated by active caspase 3, caspase 8 and caspase 9. The observed pro-apoptotic effect of IFN-gamma and TNF-alpha on ESCs could play an important role in the modulation of early implantation....

  2. 75 FR 9629 - Millington Securities, Inc. and Millington Unit Investment Trusts; Notice of Application

    Science.gov (United States)

    2010-03-03

    ... (``DSC''). For each Series, the Depositor would set a maximum sales charge per Unit, a portion of which may be collected ``up front'' (i.e., at the time an investor purchases the Units). The DSC would be.... 2. When a Unitholder redeems or sells Units, the Depositor intends to deduct any unpaid DSC from...

  3. Careers (A Course of Study). Unit II: How to Start Looking for That Job.

    Science.gov (United States)

    Turley, Kay

    Designed to train special needs students to search for a job in at least five different ways, this set of activities is the second unit in a nine-unit secondary level career course intended to provide handicapped students with the knowledge and skills necessary to succeed in the world of work. The unit begins with a pretest and vocabulary…

  4. Numbers and Measuring, Learning With TOR: MINNEMAST Coordinated Mathematics - Science Series, Unit 16.

    Science.gov (United States)

    Vogt, Elaine E., Ed.

    This volume is the sixteenth in a series of 29 coordinated MINNEMAST units in mathematics and science for kindergarten and the primary grades. Intended for use by second-grade teachers, this unit guide provides a summary and overview of the unit, a list of materials needed, and descriptions of five groups of lessons. The purposes and procedures…

  5. Between Inflation and Recession: A Literacy Unit on the American Economic System.

    Science.gov (United States)

    Lawrence, Sharon; And Others

    This four-week unit on the American economic system for secondary students is intended to be a basic literacy unit in economics and to serve as a "sampler kit" demonstrating how economics can be taught interestingly, imaginatively, and with intellectual honesty to the subject matter. The unit's goals for students include ability to list the major…

  6. 78 FR 72972 - Meeting of the United States-Colombia Environmental Affairs Council and Environmental Cooperation...

    Science.gov (United States)

    2013-12-04

    ... of the United States-Colombia Environmental Affairs Council and Environmental Cooperation Commission...) are providing notice that the United States and Colombia intend to hold the first meeting of the... implementation of Chapter 18 (Environment) of the United States- Colombia Trade Promotion Agreement (TPA) and...

  7. Multilateral Disarmament and the Special Session: Twelfth Conference on the United Nations of the Next Decade.

    Science.gov (United States)

    Stanley Foundation, Muscatine, IA.

    The report discusses issues relating to multilateral disarmament in the context of the Special Session of the United Nations General Assembly to be convened in 1978. Intended as a forum for the exchange of ideas of government leaders from the United States and other nations about the international peace-keeping role of the United Nations, the…

  8. Omega-3 fatty acid fish oil dietary supplements contain saturated fats and oxidized lipids that may interfere with their intended biological benefits.

    Science.gov (United States)

    Mason, R Preston; Sherratt, Samuel C R

    2017-01-29

    Widely available fish oil dietary supplements (DS) may contain fats and oxidized lipids in addition to the beneficial omega-3 fatty acids (OM3FAs) for which they are purchased. Little is known about the potential biological effects of these oxidized lipids. The objective of this study was to assess the fatty acid content, oxidation products, and biological effects of leading fish oil DS available in the United States. Three top-selling fish oil DS in the US were included in this analysis. Fatty acid composition was measured using gas chromatography. Lipid oxidation (primary and secondary products) was measured by spectroscopy in both DS and a prescription OM3FA product. OM3FAs were also isolated and concentrated from DS and were tested for the ability to inhibit copper-induced oxidation of human small dense low-density lipoprotein particles (sdLDL) in vitro. Fish oil DS were found to contain more than 30 different fatty acids, including 10 to 14 different saturated species comprising up to 36% of the total fatty acid content. Levels of OM3FAs also varied widely among DS (33%-79%). Primary (peroxide), secondary (anisidine), and total oxidation products exceeded maximum levels established by international standards of quality in the DS but not the prescription OM3FA product. Oxidation of sdLDL was inhibited by >95% (P saturated fat and oxidized OM3FAs found in common DS may interfere with their intended/potential biological benefits.

  9. Reflections on the Value of Mapping the Final Theory Examination in a Molecular Biochemistry Unit

    OpenAIRE

    Rajaraman Eri; Anthony Cook; Natalie Brown

    2014-01-01

    This article assesses the impact of examination mapping as a tool to enhancing assessment and teaching quality in a second-year biochemistry unit for undergraduates. Examination mapping is a process where all questions in a written examination paper are assessed for links to the unit’s intended learning outcomes. We describe how mapping a final written examination helped visualise the impact of the assessment task on intended learning outcomes and skills for that biochemistry unit. The method...

  10. Family Planning Evaluation. Abortion Surveillance Report--Legal Abortions, United States, Annual Summary, 1970.

    Science.gov (United States)

    Center for Disease Control (DHEW/PHS), Atlanta, GA.

    This report summarizes abortion information received by the Center for Disease Control from collaborators in state health departments, hospitals, and other pertinent sources. While it is intended primarily for use by the above sources, it may also interest those responsible for family planning evaluation and hospital abortion planning. Information…

  11. The Titles of the Circuit Intendants in the Qing Dynasty%清代道员职衔考述

    Institute of Scientific and Technical Information of China (English)

    周勇进

    2012-01-01

    道员,源自明代藩臬佐贰,各道设置之初,其独立性远不及后世,均各带参政、参议、副使、佥事等两司职衔守巡各地。入清后,仍沿其旧制,诸道职衔、品级各不相同。随着道制的完善,道员的地位、作用日趋固定,遂有乾隆十八年停直省守巡各道兼两司职衔之举,同时定其品秩为正四品。自此之后,道员不再是藩臬佐贰的统称,而成一独立职官名称。道员职衔经历了一个从各道坐定职衔,到以一定原则兼衔任缺,再到逐渐弱化兼衔意义,并最终去兼衔定品级的过程。%Circuit intendants (Dao) originated from vice financial commissioners and provincial judges in the Ming dynasty. The circuit was not so independent in its early stage. The circuit intendants worked as inspectors in certain areas with concurrent titles like financial commissioners and the provincial judges. The Qing dynasty inherited the Dao institution from the Ming dynasty, and each Dao had its own titles and ranks. With the development of the Dao institution, its status and function were gradually fixed up. As a result, the Qing court set the rank of circuit intedants as 4 and removed their concurrent titles in 1753. Henceforth, Circuit intendants became an independent position from vice financial commissioners and provincial judges.

  12. Monitoring the Intended and Perceived Training Load of a Professional Futsal Team Over 45 Weeks: A Case Study.

    Science.gov (United States)

    Rabelo, Felipe N; Pasquarelli, Bruno N; Gonçalves, Bruno; Matzenbacher, Fernando; Campos, Fábio A D; Sampaio, Jaime; Nakamura, Fábio Y

    2016-01-01

    The aims of this study were to compare the training load intended by a coach with the training load perceived by the players, over a 45-week professional futsal team season and to compare the variation of session rating of perceived exertion (sRPE) across different periods of the season. Eighteen Brazilian professional futsal players participated in the study. The players' rating of perceived exertion (RPE) and coach's rating of intended exertion (RIE) were collected daily throughout the study. To compare the sRPE variation, the season was divided into 4 periods as follows: preseason (PRE-SEASON), first competitive period (COMP1), intercompetition period (INTER-COMP), and second competitive period (COMP2). Based on the cluster analyses, the training sessions were classified into 3 different intensity zones (low, moderate, and high). In all the season periods and intensity zones, the players' RPEs were lower than the coach's RIE. In the low-intensity zone, the INTER-COMP demonstrated higher sRPE values than did the other periods. In the moderate-intensity zones, the INTER-COMP and COMP2 were similar. Finally, for the high-zone intensity, the PRE-SEASON demonstrated higher values than did the other periods. We concluded that the coach overestimated the training load reported by the players in almost all intensity training zones and season periods. The RPE scale does not seem to be a suitable tool when used by the coach for intended training load. Therefore, technical staff should constantly review the training goals in each season period through daily training load control, always taking into consideration the possibilities and limitations of the RPE method.

  13. Evaluation of susceptibility of polymer and rubber materials intended into contact with drinking water on biofilm formation

    Science.gov (United States)

    Szczotko, Maciej; Stankiewicz, Agnieszka; Jamsheer-Bratkowska, Małgorzata

    Plumbing materials in water distribution networks and indoor installations are constantly evolving. The application of new, more economical solutions with plastic materials eliminates the corrosion problems, however, do not fully protect the consumer against secondary microbial contamination of water intended for human consumption caused by the presence of a biofilm on the inner surface of materials applied. National Institute of Public Health - National Institute of Hygiene conducts research aimed at a comprehensive assessment of this type of materials, resulting their further marketing authorization in Poland. Evaluation and comparison of polymer and rubber materials intended to contact with water for the susceptibility to biofilm formation. Plastic materials (polyethylene, polypropylene, polyvinyl chloride) and rubber compounds (EPDM, NBR), from different manufacturers were evaluated. The study was carried out on 37 samples, which were divided into groups according to the material of which they were made. The testing was conducted according to the method based on conditions of dynamic flow of tap water. The level of bioluminescence in swabs taken from the surface of the tested materials was investigated with a luminometer. Evaluation of plastic materials does not show major objections in terms of hygienic assessment. All materials met the evaluation criteria established for methodology used. In case of rubber compounds, a substantial part clearly exceeded the limit values, which resulted in their negative assessment and elimination of these materials from domestic market. High susceptibility to the formation of biofilm in the group of products made of rubber compounds has been demonstrated. Examined plastic materials, except for several cases, do not revealed susceptibility to biofilm formation, but application of plastics for distribution of water intended for human consumption does not fully protect water from secondary, microbiological contamination. Complete

  14. Sol-forming oil-displacing system intended to enhance oil recovery from deposits with difficult-to-recover reserves

    Science.gov (United States)

    Kozlov, V. V.; Altunina, L. K.; Stasyeva, L. A.; Kuvshinov, V. A.

    2016-11-01

    The paper presents the results of laboratory tests of the sol-forming NINKA®-Z system intended to enhance oil recovery from deposits with difficult-to-recover reserves. The kinetic and rheological features of solation in the oil-displacing system have been investigated. A physical modeling of the oil displacement process was carried out under the conditions of a heterogeneous reservoir at a low temperature using the sol-forming NINKA®-Z system. The investigations have proved its high efficiency, and the system was recommended for pilot tests.

  15. Impact of Sterilisation and Strain Hardening in Drawing Process on Resistance to Electrochemical Corrosion of Wires Intended in Cardiology

    Directory of Open Access Journals (Sweden)

    Przondziono J.

    2016-03-01

    Full Text Available The study presents results of tests of impact of work hardening in cold drawing process, surface treatment and sterilisation on resistance to electrochemical corrosion of wires made of stainless steel X2CrNiMo 17-12-2 intended for cardiology. Potentiodynamic tests were performed on the ground of registered anodic polarisation curves in artificial plasma solution. Static uniaxial tension test made the ground for determination of strength characteristics of wires and the flow curve. Functions presenting the change of polarisation resistance according to strain applied in drawing process were selected.

  16. United Arab Emirates.

    Science.gov (United States)

    1985-02-01

    This discussion of the United Arab Emirates focuses on the following: the people; geography; history; government; political conditions; defense; the economy; foreign relations; and relations between the US and the United Arab Emirates. In 1983 the population was estimated at 1,194,000. In 1984 the annual growth rate was negative. Life expectancy is about 60 years. Fewer than 20% of the population are UAE citizens. Indigenous Emiris are Arab; the rest of the population includes significant numbers of other Arabs -- Palestinians, Egyptians, Jordanians, Yemenis, Omanis, as well as many Iranians, Pakistanis, Indians, and West Europeans, especially in Dubai. The UAE is in the eastern Arabian Peninsula, bounded on the north by the Persian Gulf. European and Arab pirates roamed the Trucial Coast area from the 17th century into the 19th century. Early British expeditions against the pirates led to further campaigns against their headquarters. Piracy continued intermittently until 1835, when the shaikhs agreed not to engage in hostilities at sea. Primarily in reaction to the ambitions of other European countries, the UK and the Trucial States established closer bonds in an 1892 treaty. In 1968 the British government announced its decision, reaffirmed in March 1971, to end the treaty relationship with the gulf shaikhdoms. When the British protective treaty with the Trucial Shaikhdoms ended on December 1, they became fully independent. On December 2, 1971, 6 of them entered into a union called the United Arab Emirates. The 7th, Ras al-Khaimah, joined in early 1972. Administratively, the UAE is a loose federation of 7 emirates, each with its own ruler. The pace at which local government in each emirate is evolving, from traditional to modern, is set primarily by the ruler. Under the provisional constitution of 1971, each emirate reserves considerable powers, including control over mineral rights, taxation, and police powers. In this milieu, the growth of federal powers has

  17. Novel Choices, Pun Intended

    Science.gov (United States)

    Shanley, Roger W.

    2006-01-01

    In this article, the author explains why he considers "Animal Dreams" by Barbara Kingsolver, "Ceremony" by Leslie Marmon Silko, and "The Joy Luck Club" by Amy Tan as the most desirable books for students. He cites that several questions guide him in selecting these books. These questions include the following: (1) Why recommend certain texts to…

  18. Ill-Intended Mergers?

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Adjustments expected to rules on foreign investment after accusations of malicious corporate moves Business takeovers by foreign conglomerates in China have attracted significant government attention recently, including concerns that the flurry of business maneuvers is aimed at forming foreign-controlled monopolies in the Chinese market.

  19. [Conservation Units.

    Science.gov (United States)

    Texas Education Agency, Austin.

    Each of the six instructional units deals with one aspect of conservation: forests, water, rangeland, minerals (petroleum), and soil. The area of the elementary school curriculum with which each correlates is indicated. Lists of general and specific objectives are followed by suggested teaching procedures, including ideas for introducing the…

  20. [Conservation Units.

    Science.gov (United States)

    Texas Education Agency, Austin.

    Instructional units deal with each aspect of conservation: forests, wildlife, rangelands, water, minerals, and soil. The area of the secondary school curriculum with which each is correlated is indicated. Lists of general and specific objectives are followed by suggested teaching procedures, including ideas for introducing the topic, questions to…

  1. Reaching is Better When You Get What You Want: Realtime Feedback of Intended Reaching Trajectory Despite an Unstable Environment

    Directory of Open Access Journals (Sweden)

    Justin eHorowitz

    2016-01-01

    Full Text Available Improvements in human-machine interaction may help overcome the unstable and uncertain environments that cause problems in everyday living. Here we experimentally evaluated intent feedback (IF, which estimates and displays the human operator's underlying intended trajectory in real-time. IF is a filter that combines a model of the arm with position and force data to determine the intended position. Subjects performed targeted reaching motions while seeing either their actual hand position or their estimated intent as a cursor while they experienced white noise forces rendered by a robotic handle. We found significantly better reaching performance during force exposure using the estimated intent. Additionally, in a second set of subjects with a reduced modeled stiffness, IF reduced estimated arm stiffness to about half that without IF, indicating a more relaxed state of operation. While visual distortions typically degrade performance and require an adaptation period to overcome, this particular distortion immediately enhanced performance. In the future, this method could provide novel insights into the nature of control. IF might also be applied in driving and piloting applications to best follow a person's desire in unpredictable or turbulent conditions.

  2. Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption

    Energy Technology Data Exchange (ETDEWEB)

    Vulliet, Emmanuelle, E-mail: e.vulliet@sca.cnrs.fr [Institut des Sciences Analytiques - UMR5280, Departement Service Central d' Analyse, Echangeur de Solaize, Chemin du Canal, F-69360 Solaize (France); Cren-Olive, Cecile [Institut des Sciences Analytiques - UMR5280, Departement Service Central d' Analyse, Echangeur de Solaize, Chemin du Canal, F-69360 Solaize (France)

    2011-10-15

    As part of a regional screening to evaluate the risk, for the health of populations, to certain classes of emerging substances, several families of pharmaceuticals and hormones were looked for in waters intended to drinking. Thus, 52 substances were investigated in 71 surface waters and 70 groundwaters. Results indicate that no water was free of pollutants, regardless of its origin (surface or groundwater) and the season of collect. The pharmaceuticals most frequently detected and with the highest concentration levels were salicylic acid, carbamazepine and acetaminophen. Among hormones, testosterone, androstenedione and progesterone were detected in almost all the samples. Globally the groundwaters were less contaminated than surface waters in regards pharmaceuticals frequencies and levels. On the other side, androgens and progestagens were present with comparable frequencies and levels in both compartments. The risk linked to the presence of these substances on human health is discussed. - Highlights: > Traces of 52 substances investigated in 71 surface waters and 70 groundwaters. > No water was free of pollutants, whatever its origin and the season of collect. > Globally groundwaters were less contaminated than surface waters in regards pharmaceuticals. > Hormones were present with comparable frequencies and levels in two compartments. - 52 pharmaceuticals and hormones investigated in 71 surface waters and 70 groundwaters intended to human consumption.

  3. Predicting intended use of voluntary HIV counselling and testing services among Tanzanian teachers using the theory of planned behaviour.

    Science.gov (United States)

    Kakoko, Deodatus Conatus; Astrøm, A N; Lugoe, Wycliffe L; Lie, Gro T

    2006-08-01

    The theory of planned behaviour (TPB) provides a conceptual model for understanding individual cognitions that influence behavioural intentions and enactment of the actual behaviours. This study examined the applicability of the TPB and the additional predictive role of perceived risk in predicting intended use of voluntary HIV counselling and testing (VCT) services. We conducted a cross-sectional questionnaire survey among 918 primary school teachers in the Mwanza region, Tanzania between September 2003 and November 2003. Analysis was based on 737 teachers (mean age 38.9) who had never tested for HIV. Results of the hierarchical regression analysis indicate that perceived behavioural control and attitude toward using VCT services were significant predictors of intention to use VCT services in the TPB model. Perceived behavioural control added 12% of variance to intention over and above attitudes and subjective norms, while perceived risk added 3% of variance. Socio-economic status did not moderate the predictive value of the TPB components. The present study demonstrates that the TPB is a useful conceptual framework for predicting intended use of HIV counselling and testing services among Tanzanian teachers. A theory-based VCT intervention programme among Tanzanian teachers should mainly focus on reducing social and psychological barriers related to the use of VCT services.

  4. Fabrication and anti-microbial evaluation of drug loaded polylactide space filler intended for ridge preservation following tooth extraction

    Directory of Open Access Journals (Sweden)

    Nebu George Thomas

    2011-01-01

    Full Text Available Background: The preservation or reduction of alveolar ridge resorption following tooth extraction is important in patients especially for those intended for implants at a later stage. One way to achieve this is by using membranes, graft materials, and biodegradable space fillers to prevent alveolar bone resorption and promote regeneration. A major attraction for using biodegradable and biocompatible polymers as space fillers for ridge preservation is their safety profile in comparison to xenograft materials like lyophilized bone and collagen. Materials and Methods: Biocompatible polylactide space fillers were fabricated by fusing porous polylactide particles. The sponges were loaded with drugs by placing them in the respective solutions. Pseudomonas aeruginosa was isolated from a chronic periodontitis patient and in vitro anti-microbial evaluation was done with the drug loaded sponges. Results: Chlorhexidine loaded space filler showed significant anti microbial effect against multiple drug resistant Pseudomonas aeruginosa isolated from a patient with chronic periodontitis. Conclusion: The results of this study indicate that biodegradable drug releasing polylactide space fillers has the potential to be used for ridge preservation following tooth extraction. Release of drugs in the socket may prove useful in preventing development of alveolar osteitis post extraction which can interfere with normal healing of the socket. Synthetic biodegradable polymers also exhibit a controlled degradation rate to achieve complete resorption within the intended time.

  5. Estimated United States Transportation Energy Use 2005

    Energy Technology Data Exchange (ETDEWEB)

    Smith, C A; Simon, A J; Belles, R D

    2011-11-09

    A flow chart depicting energy flow in the transportation sector of the United States economy in 2005 has been constructed from publicly available data and estimates of national energy use patterns. Approximately 31,000 trillion British Thermal Units (trBTUs) of energy were used throughout the United States in transportation activities. Vehicles used in these activities include automobiles, motorcycles, trucks, buses, airplanes, rail, and ships. The transportation sector is powered primarily by petroleum-derived fuels (gasoline, diesel and jet fuel). Biomass-derived fuels, electricity and natural gas-derived fuels are also used. The flow patterns represent a comprehensive systems view of energy used within the transportation sector.

  6. 22 CFR 1508.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-04-01

    ... Participants Regarding Transactions Doing Business with Other Persons § 1508.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into a covered... lower tiers with whom I intend to do business? 1508.330 Section 1508.330 Foreign Relations...

  7. 21 CFR 1404.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-04-01

    ... Participants Regarding Transactions Doing Business with Other Persons § 1404.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into a covered... lower tiers with whom I intend to do business? 1404.330 Section 1404.330 Food and Drugs OFFICE...

  8. 29 CFR 98.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-07-01

    ... Doing Business with Other Persons § 98.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into a covered transaction with a participant at the... with whom I intend to do business? 98.330 Section 98.330 Labor Office of the Secretary of...

  9. 29 CFR 1471.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-07-01

    ... (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 1471.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business... tiers with whom I intend to do business? 1471.330 Section 1471.330 Labor Regulations Relating to...

  10. 34 CFR 85.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-07-01

    ... Participants Regarding Transactions Doing Business with Other Persons § 85.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into a covered... tiers with whom I intend to do business? 85.330 Section 85.330 Education Office of the...

  11. 22 CFR 1006.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-04-01

    ... Participants Regarding Transactions Doing Business with Other Persons § 1006.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into a covered... lower tiers with whom I intend to do business? 1006.330 Section 1006.330 Foreign Relations...

  12. 5 CFR 919.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-01-01

    ... AND SUSPENSION (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business... persons at lower tiers with whom I intend to do business? 919.330 Section 919.330 Administrative Personnel... intend to do business? Before entering into a covered transaction with a participant at the next...

  13. 22 CFR 208.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-04-01

    ...) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 208.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into... at lower tiers with whom I intend to do business? 208.330 Section 208.330 Foreign Relations...

  14. 31 CFR 19.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-07-01

    ...) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 19.330 What requirements must I pass down to persons at lower tiers with whom I intend to do business? Before entering into... persons at lower tiers with whom I intend to do business? 19.330 Section 19.330 Money and...

  15. Exploring the Alignment of the Intended and Implemented Curriculum through Teachers' Interpretation: A Case Study of A-Level Biology Practical Work

    Science.gov (United States)

    Phaeton, Mukaro Joe; Stears, Michèle

    2017-01-01

    The research reported on here is part of a larger study exploring the alignment of the intended, implemented and attained curriculum with regard to practical work in the Zimbabwean A-level Biology curriculum. In this paper we focus on the alignment between the intended and implemented A-Level Biology curriculum through the lens of teachers'…

  16. 16 CFR 1500.53 - Test methods for simulating use and abuse of toys and other articles intended for use by children...

    Science.gov (United States)

    2010-01-01

    ... methods for simulating use and abuse of toys and other articles intended for use by children over 36 but... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test methods for simulating use and abuse of toys and other articles intended for use by children over 36 but not over 96 months of age....

  17. 16 CFR 1500.50 - Test methods for simulating use and abuse of toys and other articles intended for use by children.

    Science.gov (United States)

    2010-01-01

    ... articles intended for use by children as well as the reasonably foreseeable damage or abuse to which the... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test methods for simulating use and abuse of toys and other articles intended for use by children. 1500.50 Section 1500.50 Commercial...

  18. 16 CFR 1500.51 - Test methods for simulating use and abuse of toys and other articles intended for use by children...

    Science.gov (United States)

    2010-01-01

    ... simulating use and abuse of toys and other articles intended for use by children 18 months of age or less. (a... foreseeable use, damage, or abuse of toys and other articles intended for use by children 18 months of age or... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test methods for simulating use and abuse...

  19. 16 CFR 1500.52 - Test methods for simulating use and abuse of toys and other articles intended for use by children...

    Science.gov (United States)

    2010-01-01

    ... methods for simulating use and abuse of toys and other articles intended for use by children over 18 but... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test methods for simulating use and abuse of toys and other articles intended for use by children over 18 but not over 36 months of age....

  20. Exploring the Alignment of the Intended and Implemented Curriculum through Teachers' Interpretation: A Case Study of A-Level Biology Practical Work

    Science.gov (United States)

    Phaeton, Mukaro Joe; Stears, Michèle

    2017-01-01

    The research reported on here is part of a larger study exploring the alignment of the intended, implemented and attained curriculum with regard to practical work in the Zimbabwean A-level Biology curriculum. In this paper we focus on the alignment between the intended and implemented A-Level Biology curriculum through the lens of teachers'…

  1. A probabilistic estimate of maximum acceleration in rock in the contiguous United States

    Science.gov (United States)

    Algermissen, Sylvester Theodore; Perkins, David M.

    1976-01-01

    This paper presents a probabilistic estimate of the maximum ground acceleration to be expected from earthquakes occurring in the contiguous United States. It is based primarily upon the historic seismic record which ranges from very incomplete before 1930 to moderately complete after 1960. Geologic data, primarily distribution of faults, have been employed only to a minor extent, because most such data have not been interpreted yet with earthquake hazard evaluation in mind.The map provides a preliminary estimate of the relative hazard in various parts of the country. The report provides a method for evaluating the relative importance of the many parameters and assumptions in hazard analysis. The map and methods of evaluation described reflect the current state of understanding and are intended to be useful for engineering purposes in reducing the effects of earthquakes on buildings and other structures.Studies are underway on improved methods for evaluating the relativ( earthquake hazard of different regions. Comments on this paper are invited to help guide future research and revisions of the accompanying map.The earthquake hazard in the United States has been estimated in a variety of ways since the initial effort by Ulrich (see Roberts and Ulrich, 1950). In general, the earlier maps provided an estimate of the severity of ground shaking or damage but the frequency of occurrence of the shaking or damage was not given. Ulrich's map showed the distribution of expected damage in terms of no damage (zone 0), minor damage (zone 1), moderate damage (zone 2), and major damage (zone 3). The zones were not defined further and the frequency of occurrence of damage was not suggested. Richter (1959) and Algermissen (1969) estimated the ground motion in terms of maximum Modified Mercalli intensity. Richter used the terms "occasional" and "frequent" to characterize intensity IX shaking and Algermissen included recurrence curves for various parts of the country in the paper

  2. Freestanding midwifery units versus obstetric units

    DEFF Research Database (Denmark)

    Overgaard, Charlotte; Fenger-Grøn, Morten; Sandall, Jane

    2012-01-01

    likelihood of uncomplicated, spontaneous birth with good outcomes for mother and infant compared to women intending to give birth in an OU. The likelihood of intact perineum, use of upright position for birth and water birth was also higher. No difference was found in perinatal morbidity or third...... comparable and, in some respects, more favourable outcomes when compared to women with the same level of education intending to give birth in an OU. In this sample of low-risk women, we found that the effect of intended place on birth outcomes did not differ with women’s level of education. Conclusion FMU...... and infant compared to women intending to give birth in an OU. All women should be provided with adequate information about different care models and supported in making an informed decision about the place of birth....

  3. FLYING UNITED

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Apart from selling hundreds of airplanes to China, Boeing buys locally made aircraft parts and transfers technology, in the true spirit of partnership Whenever Boeing's senior manager hear of a visit by one of China's state leaders, it's no doubt cause for celebration. Since China and the United States established diplomatic ties in 1978, every official trip by China's top statesmen has included a meeting with Boeing that

  4. A Taxonomic Analysis of the Intended Learning Outcomes of the Primary School Social Studies Curriculum for 7th Graders

    Directory of Open Access Journals (Sweden)

    Ahmet Ali Gazel

    2012-04-01

    Full Text Available Rapid changes held as a result of scientific and technological developments affect our lives from all perspectives. Educational activities are also affected by this process. The previous primary school curriculum in Turkey has been gradually given up since 2005. “Constructivist” curricula have been developed. The Social Studies curriculum has been renewed in accordance with this conception as well. Therefore, all elements of the curriculum have been changed. Being defined as “objectives or goals” in the previous curriculum, the intended learning outcomes (ILOs of the Social Studies curriculum for 7th graders have been taxonomically analyzed. Findings indicated the ILOs of the Social Studies curriculum for 7th graders intensively take place in cognitive taxonomy and the number of the ILOs related to other taxonomies is lacking. It was seen that ILOs are compatible with content and activities in general. Through the findings and the literature, some recommendations were made.

  5. Effectiveness of psychological interventions intended to promote adjustment of children with cancer and their parents: an overview

    Directory of Open Access Journals (Sweden)

    Amanda Muglia-Wechsler

    2014-01-01

    Full Text Available This article aims at providing a general overview of psychological interventions intended to promote psychological adjustment of children with cancer and their parents. To achieve this goal, we reviewed published articles between 1998-2010, using a combination of the following key words: psychosocial intervention, psychotherapy, trial, treatment, adjustment, wellbeing, adaptation, cancer, childhood cancer, pediatric cancer, anxiety and depression in the electronic databases: Psycinfo, Medline, Scielo, Lilacs, Psicodoc and Psyarticles. Fourteen articles were found and analyses show that most interventions had some efficacy in the psychological adjustment of children and their parents; nevertheless, there is a limited number of treatments that can in fact be considered effective. The convenience of psychological interventions is discussed and how they must comprehend strengths and the promotion of psychological health and should not be based solely on deficits and psychopathological models. Possibly, this reorientation will help fostering significant clinic changes regarding the stress associated to cancer and its treatment.

  6. The Intellectual Demands of the Intended Primary Science Curriculum in Korea and Singapore: An analysis based on revised Bloom's taxonomy

    Science.gov (United States)

    Lee, Yew-Jin; Kim, Mijung; Yoon, Hye-Gyoung

    2015-09-01

    While there has been a remarkable worldwide convergence in the emphases of primary science curricula over the last four decades, the cognitive and knowledge demands that they make on learners have not been well-researched. Without knowing what these intellectual or epistemic requirements are when learning science in school, issues concerning curricular alignment and access to abstract disciplinary knowledge are also likely to occur. To highlight the value of such forms of analyses, we examine the intended primary science curricula from Korea and Singapore using revised Bloom's taxonomy, as well as describe some of their general features for teaching. The results contribute insights into the complexities of the science curriculum among two similar yet different educational systems that have performed well in international science achievement tests at primary levels.

  7. Accounting approach for long manufacturing cycle assets intended for sale according to the Order 3055/2009

    Directory of Open Access Journals (Sweden)

    Busuioceanu, S.

    2010-12-01

    Full Text Available In the context of efforts of compatibility of existing accounting systems and regulations worldwide, the importance of accounting information and communication language to various beneficiaries is very important. Provision of compliance of accounting regulations with the European Directives in the field is a continuous process that requires adjustment of financial statements to business demands. In this context long term manufacturing cycle assets intended for sale are included in the class of inventories, but “when there is a change of use of tangible assets, meaning that it is to be improved in the light of sale, upon the date of making the decision to change the destination, the accounting registers the transfer of assets from the class of tangible fixed assets to inventories“.

  8. Fecal pollution source tracking in waters intended for human supply based on archaeal and bacterial genetic markers.

    Science.gov (United States)

    Bianco, Kayo; Barreto, Camila; Oliveira, Samara Sant'Anna; Pinto, Leonardo Henriques; Albano, Rodolpho Mattos; Miranda, Catia Chaia; Clementino, Maysa Mandetta

    2015-12-01

    The determination of fecal pollution sources in aquatic ecosystems is essential to estimate associated health risks. In this study, we evaluate eight microbial source tracking (MST) markers including host-specific Bacteroidales and Methanobrevibacter spp. for discrimination between human, bovine, equine, and swine fecal contamination in waters intended for human supply. Overall, the novel host-specific archaeal and bacterial primers proposed in this study demonstrated high sensitivity and specificity. Markers for the Archaea domain were more prevalent in the fecal and water samples studied. We conclude that the investigations regarding the sources of fecal pollution in public water supplies can contribute to improve the quality of human health. To our knowledge, this is the first analysis using both archaeal and bacterial fecal MST markers on tropical water bodies of Rio de Janeiro city, Brazil.

  9. Professional Knowledge and Skills Required for Accounting Majors Who Intend to Become Auditors: Perceptions of External Auditors

    Directory of Open Access Journals (Sweden)

    Ali Uyar

    2011-07-01

    Full Text Available This research aims to ascertain the professional knowledge and the skills/attributes that are considered important by external auditors for a graduate who intends to be an auditor. For this purpose, we conducted a survey on external auditors in Turkey. The research has two dimensions: skills dimension (twenty one items and professional knowledge dimension (twenty four items. The results indicated that all skills except “knowledge of accounting software” are perceived to be important or very important for the auditing profession. Among the most important skills that graduates are expected to possess are ethics, teamwork, and honesty. The results also demonstrated that some courses are perceived to be extremely necessary, e.g. Auditing, Microsoft Office Programs, Accounting and Financial Reporting Standards, Financial Statement Analysis, Financial Accounting, Capital Market Board Regulations, Cost Accounting, and Managerial Accounting. In addition, cross analyses indicated that there are significant differences among subgroups based on gender, education, auditing firm, experience, and job title.

  10. Distinction between the literal and intended meanings of sentences: a functional magnetic resonance imaging study of metaphor and sarcasm.

    Science.gov (United States)

    Uchiyama, Hitoshi T; Saito, Daisuke N; Tanabe, Hiroki C; Harada, Tokiko; Seki, Ayumi; Ohno, Kousaku; Koeda, Tatsuya; Sadato, Norihiro

    2012-05-01

    To comprehend figurative utterances such as metaphor or sarcasm, a listener must both judge the literal meaning of the statement and infer the speaker's intended meaning (mentalizing; Amodio and Frith, 2006). To delineate the neural substrates of pragmatic comprehension, we conducted functional magnetic resonance imaging (fMRI) with 20 normal adult volunteers. Participants read short stories followed by a target sentence. Depending on the context provided by the preceding stories, the target sentences were classified as follows: (1) metaphor versus literally coherent; (2) metaphor versus literally incoherent; (3) sarcasm versus literally coherent; and (4) sarcasm versus literally incoherent. For each task pair, we directly compared the activations evoked by the same target sentences in the different contexts. The contrast images were incorporated into a 2 (metaphor and sarcasm)×2 (literal coherency and incoherency) design. Metaphor-specific activation was found in the head of the caudate, which might be involved in associating statements with potential meanings, and restricting sentence meanings within a set of possible candidates for what the speaker intended. Sarcasm-specific activation was found in the left amygdala, which is an important component of the neural substrates of social behavior. Conjunction analysis revealed that both metaphor and sarcasm activated the anterior rostral medial frontal cortex (arMFC), which is a key node of mentalizing. A distinct literal coherency effect was found in the orbital MFC, which is thought to be involved in monitoring. These mesial frontal areas are jointly involved in monitoring literal coherency and mentalizing within social contexts in order to comprehend the pragmatic meanings of utterances.

  11. Tracking implementation and (un)intended consequences: a process evaluation of an innovative peripheral health facility financing mechanism in Kenya.

    Science.gov (United States)

    Waweru, Evelyn; Goodman, Catherine; Kedenge, Sarah; Tsofa, Benjamin; Molyneux, Sassy

    2016-03-01

    In many African countries, user fees have failed to achieve intended access and quality of care improvements. Subsequent user fee reduction or elimination policies have often been poorly planned, without alternative sources of income for facilities. We describe early implementation of an innovative national health financing intervention in Kenya; the health sector services fund (HSSF). In HSSF, central funds are credited directly into a facility's bank account quarterly, and facility funds are managed by health facility management committees (HFMCs) including community representatives. HSSF is therefore a finance mechanism with potential to increase access to funds for peripheral facilities, support user fee reduction and improve equity in access. We conducted a process evaluation of HSSF implementation based on a theory of change underpinning the intervention. Methods included interviews at national, district and facility levels, facility record reviews, a structured exit survey and a document review. We found impressive achievements: HSSF funds were reaching facilities; funds were being overseen and used in a way that strengthened transparency and community involvement; and health workers' motivation and patient satisfaction improved. Challenges or unintended outcomes included: complex and centralized accounting requirements undermining efficiency; interactions between HSSF and user fees leading to difficulties in accessing crucial user fee funds; and some relationship problems between key players. Although user fees charged had not increased, national reduction policies were still not being adhered to. Finance mechanisms can have a strong positive impact on peripheral facilities, and HFMCs can play a valuable role in managing facilities. Although fiduciary oversight is essential, mechanisms should allow for local decision-making and ensure that unmanageable paperwork is avoided. There are also limits to what can be achieved with relatively small funds in

  12. [Palliative care workshop primarily aimed for physicians and nurses in order to improve the care of the end-of- life homecare patient].

    Science.gov (United States)

    Sato, Kyoko; Metoki, Yoko; Mori, Mitsuko; Arino, Kaoru; Ikemizu, Ayumi; Nito, Noriko; Yoshikawa, Sachiko; Tsutazawa, Tomomi; Oi, Fumiko; Ando, Takashi; Tokuno, Kenji; Ishimaru, Haruo; Ishiguro, Hiroshi; Tsutsui, Shoko; Miyamori, Tadashi

    2011-12-01

    Since 2008, we held a palliative care workshop primarily aimed for physicians, who engaged in clinical practice for cancer treatment. In order to improve the end-of-life stage patient care at home, we made all sorts of efforts not only for physicians, but we also made a workshop available for healthcare professionals to participate. There were more than 60 people participated the workshop: our 20% of physicians and 24% of nurses, 13% of nearby hospital and clinic physicians, 12% of pharmacists and 17% of nurses. According to our questionnaire survey, more than 90% of the participants were satisfied with the workshop. Only 8% of the participants expressed that the workshop was rather difficult. From our analysis of the results, it was clear that we attained a high level of participants' satisfaction.

  13. Radical Resection of a Primarily Unresectable Pancreatic Cancer After Neoadjuvant Chemotherapy Using Gemcitabine, TS-1, and Nafamostat Mesilate; Report of a Case

    Science.gov (United States)

    Fujiwara, Yuki; Shiba, Hiroaki; Uwagawa, Tadashi; Futagawa, Yasuro; Misawa, Takeyuki; Yanaga, Katsuhiko

    2015-01-01

    A 58-year-old male visited his primary physician for epigastric and back pain. Abdominal-enhanced computed tomography (CT) revealed a hypovascular pancreatic tumor measuring 17 × 11 mm in the uncinate process of the pancreas extending into the superior mesenteric plexus for greater than 180°. With a diagnosis of unresectable pancreatic cancer, the patient received gemcitabine and TS-1 with arterial infusion of nafamostat mesilate. After 3 courses of chemotherapy, enhanced CT revealed a decrease in size of the pancreatic tumor with no lymph node and distant metastasis and improved invasion of the superior mesenteric plexus down to 120°. The patient underwent R0 pancreaticoduodenectomy. The patient made a satisfactory recovery without complications and was discharged on postoperative day 10. We herein report the first curative resected case of a primarily unresectable pancreatic cancer after neoadjuvant chemotherapy using gemcitabine, TS-1, and nafamostat mesilate. PMID:25692432

  14. Community perceptions of safety in relation to perceived youth violence-delinquency in a primarily native Hawaiian and Asian American community in Hawai'i.

    Science.gov (United States)

    Hishinuma, Earl S; Chang, Janice Y; Soli, Faapisa M

    2012-02-01

    Perception of safety is an important component to the well-being of community members in their own neighborhood. The present study was the first of its kind to model community perception of safety utilizing a primarily Native Hawaiian and Asian American community sample (N = 101) and with perceived youth violence and delinquency as prominent potential influences. The study found that the majority of participants felt that several types of youth violence and delinquency were problems in the community. The overall social-ecological model evidenced a strong fit and indicated that community perception of safety was adversely impacted by perceived youth violence and delinquency and increased through positive relations with neighbors. The implications included the need for a more comprehensive approach to positive youth development and community capacity-building, including incorporation of cultural components, and to determine whether the model is applicable to other minority communities.

  15. A Literature Unit for "Dragon's Gate" by Laurence Yep.

    Science.gov (United States)

    Thomas-Vallens, Mary

    Intended as a an aid to classroom teachers, this 52-page handbook presents a literature unit based on the children and young people's book, "Dragon's Gate" by Laurence Yep. It begins with sample lesson plans, pre-reading activities, author information, a book summary, vocabulary lists and suggested vocabulary activities. Next, chapters…

  16. The Systematization of Knowledge and Intensification of the Learning Unit

    Science.gov (United States)

    Erdniev, P. M.; Erdniev, B. P.

    1976-01-01

    Describes a teaching technique based on learning unit reinforcement which is intended to help students learn more in less time. The authors maintain that the systematic application of the method resulted in a 20 percent saving of instruction time as compared with the general standards in Soviet elementary and secondary schools. (Author/DB)

  17. The European Currency Unit: An Economical, Financial, and Political Currency.

    Science.gov (United States)

    Strysick, Pam

    Intended to provide a basic understanding of the history and complexity of a relatively new foreign currency measure, this paper briefly describes the history leading to the formation of the European Economic Community (EEC), its objectives, its governance structure, and its development of the European Currency Unit (ECU) as a means of stabilizing…

  18. Seminar on Sanitation for Restaurant Owners and Managers. Unit II.

    Science.gov (United States)

    Threlkeld, Joyce C.

    Intended for use in conducting short seminars on sanitation for restaurant owners and managers, unit two of the curriculum guide is organized to provide four hours of classroom instruction. Four major concepts are emphasized. The first concept, providing sanitary conditions in food service establishments, discusses safe use and storage of cleaning…

  19. Careers (A Course of Study). Unit V: Forms, Forms, Forms.

    Science.gov (United States)

    Turley, Kay

    Designed to enable special needs students to understand and complete various job-related forms, this set of activities devoted to forms encountered before and after one obtains a job is the fifth in a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world of…

  20. A Literature Unit for "Dragon's Gate" by Laurence Yep.

    Science.gov (United States)

    Thomas-Vallens, Mary

    Intended as a an aid to classroom teachers, this 52-page handbook presents a literature unit based on the children and young people's book, "Dragon's Gate" by Laurence Yep. It begins with sample lesson plans, pre-reading activities, author information, a book summary, vocabulary lists and suggested vocabulary activities. Next, chapters…

  1. United States

    Directory of Open Access Journals (Sweden)

    Stephen Bernow

    1998-12-01

    Full Text Available This paper presents and discusses an integrated set of policies designed to reduce U.S. carbon emissions over the next four decades. This innovation path also aims to promote environmental quality, particularly by reducing emissions of criteria air pollutants, to reduce U.S. dependence on imported oil, and to induce technological innovation and diffusion in energy production and consumption. The innovation path would reduce economy-wide carbon emissions by 26% below baseline projections for 2010 and by 62% below baseline projections for 2030; this translates into 10% below 1990 levels in 2010 and 45% below 1990 levels in 2030. Emissions of criteria pollutants also would be significantly reduced, as would petroleum imports by the United States. Moreover, the innovation path would yield cumulative net savings for the United States of $218 billion (1993 dollars through 2010, or $19 billion on a leveled annual basis, and would result in 800,000 additional jobs nationwide by 2010. Although the overall findings from the innovation path analysis are robust, the results should be taken as indicative, rather than precisely predictive, owing to uncertainties in future costs, prices, technology performance, and consumer behavior.

  2. Chlamydia trachomatis recombinant MOMP encapsulated in PLGA nanoparticles triggers primarily T helper 1 cellular and antibody immune responses in mice: a desirable candidate nanovaccine

    Directory of Open Access Journals (Sweden)

    Fairley SJ

    2013-05-01

    Full Text Available Stacie J Fairley, Shree R Singh, Abebayehu N Yilma, Alain B Waffo, Praseetha Subbarayan, Saurabh Dixit, Murtada A Taha, Chino D Cambridge, Vida A Dennis Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL, USA Abstract: We recently demonstrated by in vitro experiments that PLGA (poly D, L-lactide-co-glycolide potentiates T helper 1 (Th1 immune responses induced by a peptide derived from the recombinant major outer membrane protein (rMOMP of Chlamydia trachomatis, and may be a promising vaccine delivery system. Herein we evaluated the immune-potentiating potential of PLGA by encapsulating the full-length rMOMP (PLGA-rMOMP, characterizing it in vitro, and investigating its immunogenicity in vivo. Our hypothesis was that PLGA-rMOMP triggers Th1 immune responses in mice, which are desirable prerequisites for a C. trachomatis candidate nanovaccine. Physical-structural characterizations of PLGA-rMOMP revealed its size (approximately 272 nm, zeta potential (−14.30 mV, apparent spherical smooth morphology, and continuous slow release pattern. PLGA potentiated the ability of encapsulated rMOMP to trigger production of cytokines and chemokines by mouse J774 macrophages. Flow cytometric analyses revealed that spleen cells from BALB/c mice immunized with PLGA-rMOMP had elevated numbers of CD4+ and CD8+ T cell subsets, and secreted more rMOMP-specific interferon-gamma (Th1 and interleukin (IL-12p40 (Th1/Th17 than IL-4 and IL-10 (Th2 cytokines. PLGA-rMOMP-immunized mice produced higher serum immunoglobulin (IgG and IgG2a (Th1 than IgG1 (Th2 rMOMP-specific antibodies. Notably, sera from PLGA-rMOMP-immunized mice had a 64-fold higher Th1 than Th2 antibody titer, whereas mice immunized with rMOMP in Freund's adjuvant had only a four-fold higher Th1 than Th2 antibody titer, suggesting primarily induction of a Th1 antibody response in PLGA-rMOMP-immunized mice. Our data underscore PLGA as an effective delivery system for a C

  3. Clarification of When Products Made or Derived From Tobacco Are Regulated as Drugs, Devices, or Combination Products; Amendments to Regulations Regarding "Intended Uses." Final rule.

    Science.gov (United States)

    2017-01-09

    The Food and Drug Administration (FDA) is issuing this final rule to describe the circumstances in which a product made or derived from tobacco that is intended for human consumption will be subject to regulation as a drug, device, or a combination product under the Federal Food, Drug, and Cosmetic Act (the FD&C Act). This action is intended to provide direction to regulated industry and to help avoid consumer confusion.

  4. Understanding the Goals of Everyday Instrumental Actions Is Primarily Linked to Object, Not Motor-Kinematic, Information: Evidence from fMRI

    Science.gov (United States)

    Nicholson, Toby; Roser, Matt; Bach, Patric

    2017-01-01

    Prior research conceptualised action understanding primarily as a kinematic matching of observed actions to own motor representations but has ignored the role of object information. The current study utilized fMRI to identify (a) regions uniquely involved in encoding the goal of others’ actions, and (b) to test whether these goal understanding processes draw more strongly on regions involved in encoding object semantics or movement kinematics. Participants watched sequences of instrumental actions while attending to either the actions’ goal (goal task), the movements performed (movement task) or the objects used (object task). The results confirmed, first, a unique role of the inferior frontal gyrus, middle temporal gyrus and medial frontal gyrus in action goal understanding. Second, they show for the first time that activation in the goal task overlaps directly with object- but not movement-related activation. Moreover, subsequent parametric analyses revealed that movement-related regions become activated only when goals are unclear, or observers have little action experience. In contrast to motor theories of action understanding, these data suggest that objects—rather than movement kinematics—carry the key information about others’ actions. Kinematic information is additionally recruited when goals are ambiguous or unfamiliar. PMID:28081175

  5. Hereditary papillary renal cell carcinoma primarily diagnosed in a cervical lymph node: a case report of a 30-year-old woman with multiple metastases

    Directory of Open Access Journals (Sweden)

    Behnes Carl Ludwig

    2013-01-01

    Full Text Available Abstract Background Papillary renal cell carcinoma is a rare cancer. Some cases can be attributed to individuals with hereditary renal cell carcinomas usually consisting of the clear cell subtype. In addition, two syndromes with hereditary papillary renal cell carcinoma have been described. One is the hereditary leiomyomatosis and renal cell carcinoma, which is characterized by cutaneous and uterine leiomyomas and renal cell carcinoma mostly consisting of the papillary renal cell carcinoma type II with a worse prognosis. Case presentation We describe a case of a 30-year-old woman with hereditary leiomyomatosis and renal cell carcinoma syndrome with extensively metastasized papillary renal cell carcinoma, primarily diagnosed in a cervical lymph node lacking leiomyomas at any site. Conclusion Papillary renal cell carcinoma in young patients should be further investigated for a hereditary variant like the hereditary leiomyomatosis and renal cell carcinoma even if leiomyomas could not be detected. A detailed histological examination and search for mutations is essential for the survival of patients and relatives.

  6. Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival.

    Science.gov (United States)

    Hastings, G A; Coleman, T A; Haudenschild, C C; Stefansson, S; Smith, E P; Barthlow, R; Cherry, S; Sandkvist, M; Lawrence, D A

    1997-12-26

    A cDNA clone for the serine proteinase inhibitor (serpin), neuroserpin, was isolated from a human whole brain cDNA library, and recombinant protein was expressed in insect cells. The purified protein is an efficient inhibitor of tissue type plasminogen activator (tPA), having an apparent second-order rate constant of 6. 2 x 10(5) M-1 s-1 for the two-chain form. However, unlike other known plasminogen activator inhibitors, neuroserpin is a more effective inactivator of tPA than of urokinase-type plasminogen activator. Neuroserpin also effectively inhibited trypsin and nerve growth factor-gamma but reacted only slowly with plasmin and thrombin. Northern blot analysis showed a 1.8 kilobase messenger RNA expressed predominantly in adult human brain and spinal cord, and immunohistochemical studies of normal mouse tissue detected strong staining primarily in neuronal cells with occasionally positive microglial cells. Staining was most prominent in the ependymal cells of the choroid plexus, Purkinje cells of the cerebellum, select neurons of the hypothalamus and hippocampus, and in the myelinated axons of the commissura. Expression of tPA within these regions is reported to be high and has previously been correlated with both motor learning and neuronal survival. Taken together, these data suggest that neuroserpin is likely to be a critical regulator of tPA activity in the central nervous system, and as such may play an important role in neuronal plasticity and/or maintenance.

  7. Is Walking Capacity in Subjects with Multiple Sclerosis Primarily Related to Muscle Oxidative Capacity or Maximal Muscle Strength? A Pilot Study

    Directory of Open Access Journals (Sweden)

    Dominique Hansen

    2014-01-01

    Full Text Available Background and Purpose. Walking capacity is reduced in subjects with multiple sclerosis (MS. To develop effective exercise interventions to enhance walking capacity, it is important to determine the impact of factors, modifiable by exercise intervention (maximal muscle strength versus muscle oxidative capacity, on walking capacity. The purpose of this pilot study is to discriminate between the impact of maximal muscle strength versus muscle oxidative capacity on walking capacity in subjects with MS. Methods. From 24 patients with MS, muscle oxidative capacity was determined by calculation of exercise-onset oxygen uptake kinetics (mean response time during submaximal exercise bouts. Maximal muscle strength (isometric knee extension and flexion peak torque was assessed on dynamometer. All subjects completed a 6-minute walking test. Relationships between walking capacity (as a percentage of normal value and muscle strength (of knee flexors and extensors versus muscle oxidative capacity were assessed in multivariate regression analyses. Results. The expanded disability status score (EDSS showed a significant univariate correlation (r=-0.70, P<0.004 with walking capacity. In multivariate regression analyses, EDSS and mean response time, but not muscle strength, were independently related to walking capacity (P<0.05. Conclusions. Walking distance is, next to disability level and not taking neurologic symptoms/deficits into account, primarily related to muscle oxidative capacity in subjects with MS. Additional study is needed to further examine/verify these findings.

  8. Bacterial diversity shift determined by different diets in the gut of the spotted wing fly Drosophila suzukii is primarily reflected on acetic acid bacteria

    KAUST Repository

    Vacchini, Violetta

    2016-11-25

    The pivotal role of diet in shaping gut microbiota has been evaluated in different animal models, including insects. Drosophila flies harbour an inconstant microbiota among which acetic acid bacteria (AAB) are important components. Here, we investigated the bacterial and AAB components of the invasive pest Drosophila suzukii microbiota, by studying the same insect population separately grown on fruit-based or non-fruit artificial diet. AAB were highly prevalent in the gut under both diets (90 and 92% infection rates with fruits and artificial diet, respectively). Fluorescent in situ hybridization and recolonization experiments with green fluorescent protein (Gfp)-labelled strains showed AAB capability to massively colonize insect gut. High-throughput sequencing on 16S rRNA gene indicated that the bacterial microbiota of guts fed with the two diets clustered separately. By excluding AAB-related OTUs from the analysis, insect bacterial communities did not cluster separately according to the diet, suggesting that diet-based diversification of the community is primarily reflected on the AAB component of the community. Diet influenced also AAB alpha-diversity, with separate OTU distributions based on diets. High prevalence, localization and massive recolonization, together with AAB clustering behaviour in relation to diet, suggest an AAB role in the D. suzukii gut response to diet modification. This article is protected by copyright. All rights reserved.

  9. Negative effects on survival and performance of Norway spruce seedlings colonized by dark septate root endophytes are primarily isolate-dependent.

    Science.gov (United States)

    Tellenbach, Christoph; Grünig, Christoph R; Sieber, Thomas N

    2011-09-01

    Root endophytes are common and genetically highly diverse suggesting important ecological roles. Yet, relative to above-ground endophytes, little is known about them. Dark septate endophytic fungi of the Phialocephala fortinii s.l.-Acephala applanata species complex (PAC) are ubiquitous root colonizers of conifers and Ericaceae, but their ecological function is largely unknown. Responses of Norway spruce seedlings of two seed provenances to inoculations with isolates of four PAC species were studied in vitro. In addition, isolates of Phialocephala subalpina from two populations within and one outside the natural range of Norway spruce were also included to study the effect of the geographic origin of P. subalpina on host response. The interaction of PAC with Norway spruce ranged from neutral to highly virulent and was primarily isolate-dependent. Variation in virulence was much higher within than among species, nonetheless only isolates of P. subalpina were highly virulent. Disease caused by P. subalpina genotypes from the native range of Norway spruce was more severe than that induced by genotypes from outside the natural distribution of Norway spruce. Virulence was not correlated with the phylogenetic relatedness of the isolates but was positively correlated with the extent of fungal colonization as measured by quantitative real-time PCR.

  10. Salinity-induced inhibition of growth in the aquatic pteridophyte Azolla microphylla primarily involves inhibition of photosynthetic components and signaling molecules as revealed by proteome analysis.

    Science.gov (United States)

    Thagela, Preeti; Yadav, Ravindra Kumar; Mishra, Vagish; Dahuja, Anil; Ahmad, Altaf; Singh, Pawan Kumar; Tiwari, Budhi Sagar; Abraham, Gerard

    2017-01-01

    Salinity stress causes adverse physiological and biochemical changes in the growth and productivity of a plant. Azolla, a symbiotic pteridophyte and potent candidate for biofertilizer due to its nitrogen fixation ability, shows reduced growth and nitrogen fixation during saline stress. To better understand regulatory components involved in salinity-induced physiological changes, in the present study, Azolla microphylla plants were exposed to NaCl (6.74 and 8.61 ds/m) and growth, photochemical reactions of photosynthesis, ion accumulation, and changes in cellular proteome were studied. Maximum dry weight was accumulated in control and untreated plant while a substantial decrease in dry weight was observed in the plants exposed to salinity. Exposure of the organism to different concentrations of salt in hydroponic conditions resulted in differential level of Na(+) and K(+) ion accumulation. Comparative analysis of salinity-induced proteome changes in A. microphylla revealed 58 salt responsive proteins which were differentially expressed during the salt exposure. Moreover, 42 % spots among differentially expressed proteins were involved in different signaling events. The identified proteins are involved in photosynthesis, energy metabolism, amino acid biosynthesis, protein synthesis, and defense. Downregulation of these key metabolic proteins appears to inhibit the growth of A. microphylla in response to salinity. Altogether, the study revealed that in Azolla, increased salinity primarily affected signaling and photosynthesis that in turn leads to reduced biomass.

  11. Bacterial diversity shift determined by different diets in the gut of the spotted wing fly Drosophila suzukii is primarily reflected on acetic acid bacteria.

    Science.gov (United States)

    Vacchini, Violetta; Gonella, Elena; Crotti, Elena; Prosdocimi, Erica M; Mazzetto, Fabio; Chouaia, Bessem; Callegari, Matteo; Mapelli, Francesca; Mandrioli, Mauro; Alma, Alberto; Daffonchio, Daniele

    2017-04-01

    The pivotal role of diet in shaping gut microbiota has been evaluated in different animal models, including insects. Drosophila flies harbour an inconstant microbiota among which acetic acid bacteria (AAB) are important components. Here, we investigated the bacterial and AAB components of the invasive pest Drosophila suzukii microbiota, by studying the same insect population separately grown on fruit-based or non-fruit artificial diet. AAB were highly prevalent in the gut under both diets (90 and 92% infection rates with fruits and artificial diet respectively). Fluorescent in situ hybridization and recolonization experiments with green fluorescent protein (Gfp)-labelled strains showed AAB capability to massively colonize insect gut. High-throughput sequencing on 16S rRNA gene indicated that the bacterial microbiota of guts fed with the two diets clustered separately. By excluding AAB-related OTUs from the analysis, insect bacterial communities did not cluster separately according to the diet, suggesting that diet-based diversification of the community is primarily reflected on the AAB component of the community. Diet influenced also AAB alpha-diversity, with separate OTU distributions based on diets. High prevalence, localization and massive recolonization, together with AAB clustering behaviour in relation to diet, suggest an AAB role in the D. suzukii gut response to diet modification. © 2016 Society for Applied Microbiology and John Wiley & Sons Ltd.

  12. STO Feeder Cells Are Useful for Propagation of Primarily Cultured Human Deciduous Dental Pulp Cells by Eliminating Contaminating Bacteria and Promoting Cellular Outgrowth.

    Science.gov (United States)

    Murakami, Tomoya; Saitoh, Issei; Inada, Emi; Kurosawa, Mie; Iwase, Yoko; Noguchi, Hirofumi; Terao, Yutaka; Yamasaki, Youichi; Hayasaki, Haruaki; Sato, Masahiro

    2013-12-30

    STO feeder cells, a line established from mouse SIM embryonic fibroblasts, have been frequently used for establishing embryonic stem cells and maintaining them in an undifferentiated state. There are some reports demonstrating that fibroblastic cells have the ability to phagocytose Gram-positive bacterium (e.g., streptococci and staphylococci). In this study, we examined the possibility that STO cells could phagocytose Streptococcus mutans (a bacteria causing tooth decay), which always contaminates cultures of primarily isolated human deciduous dental pulp cells (HDDPCs). Simple cultivation of the primary HDDPCs in the absence of STO cells allowed S. mutans to massively propagate in the medium, thus leading to an opaque medium. In contrast, there was no bacterial contamination in the cultures containing mitomycin C (MMC)-inactivated STO cells. Furthermore, STO cells indicated bacterial phagocytic activity under fluorescent microscopy with the dye pHrodo. Besides removal of contaminating bacteria, STO feeder cells allowed the HDDPCs to spread out. These data suggest that MMC-treated STO cells can be useful for propagation of HDDPCs by eliminating contaminating bacteria and by promoting cellular outgrowth.

  13. Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes.

    Directory of Open Access Journals (Sweden)

    Bryan S Briney

    Full Text Available A number of antibodies that efficiently neutralize microbial targets contain long heavy chain complementarity determining region 3 (HCDR3 loops. For HIV, several of the most broad and potently neutralizing antibodies have exceptionally long HCDR3s. Two broad potently neutralizing HIV-specific antibodies, PG9 and PG16, exhibit secondary structure. Two other long HCDR3 antibodies, 2F5 and 4E10, protect against mucosal challenge with SHIV. Induction of such long HCDR3 antibodies may be critical to the design of an effective vaccine strategy for HIV and other pathogens, however it is unclear at present how to induce such antibodies. Here, we present genetic evidence that human peripheral blood antibodies containing long HCDR3s are not primarily generated by insertions introduced during the somatic hypermutation process. Instead, they are typically formed by processes occurring as part of the original recombination event. Thus, the response of B cells encoding antibodies with long HCDR3s results from selection of unusual clones from the naïve repertoire rather than through accumulation of insertions. These antibodies typically use a small subset of D and J gene segments that are particularly suited to encoding long HCDR3s, resulting in the incorporation of highly conserved genetic elements in the majority of antibody sequences encoding long HCDR3s.

  14. Genotoxicity assessment of propyl thiosulfinate oxide, an organosulfur compound from Allium extract, intended to food active packaging.

    Science.gov (United States)

    Mellado-García, P; Maisanaba, S; Puerto, M; Llana-Ruiz-Cabello, M; Prieto, A I; Marcos, R; Pichardo, S; Cameán, A M

    2015-12-01

    Essential oils from onion (Allium cepa L.), garlic (Allium sativum L.), and their main components, such as propyl thiosulfinate oxide (PTSO) are being intended for active packaging with the purpose of maintaining and extending food product quality and shelf life. The present work aims to assess for the first time the potential mutagenicity/genotoxicity of PTSO (0-50 µM) using the following battery of genotoxicity tests: (1) the bacterial reverse-mutation assay in Salmonella typhimurium (Ames test, OECD 471); (2) the micronucleus test (OECD 487) (MN) and (3) the mouse lymphoma thymidine-kinase assay (OECD 476) (MLA) on L5178YTk(+/-), cells; and (4) the comet assay (with and without Endo III and FPG enzymes) on Caco-2 cells. The results revealed that PTSO was not mutagenic in the Ames test, however it was mutagenic in the MLA assay after 24 h of treatment (2.5-20 µM). The parent compound did not induce MN on mammalian cells; however, its metabolites (in the presence S9) produced positive results (from 15 µM). Data from the comet assay indicated that PTSO did not induce DNA breaks or oxidative DNA damage. Further in vivo genotoxicity tests are needed to confirm its safety before it is used as active additive in food packaging.

  15. Lactobacillus rhamnosus RC007 intended for feed additive: immune-stimulatory properties and ameliorating effects on TNBS-induced colitis.

    Science.gov (United States)

    Dogi, C; García, G; De Moreno de LeBlanc, A; Greco, C; Cavaglieri, L

    2016-09-01

    Lactobacillus rhamnosus RC007 is a potential probiotic bacterium that can exert beneficial effects as supplement for animal feed, by improving the immune status in healthy host, and by providing therapeutic benefits to infected/inflamed animals. The aim of the present work was to evaluate in vivo the beneficial properties of L. rhamnosus RC007, intended for animal feed, when administered to healthy and trinitro-benzene-sulfonic-acid (TNBS) colitis induced BALB/c mice. The administration of L. rhamnosus RC007 to healthy mice during 10 days increased the phagocytic activity of peritoneal macrophages and the number of immunoglobulin A+ cells in the lamina proper of the small intestine. Significant increases of monocyte chemotactic protein 1, interleukin (IL)-10 and tumour necrosis factor alpha (TNF-α) concentrations, and in the ratio between anti- and pro-inflammatory cytokines (IL-10/TNF-α) were observed in intestinal fluids after administration of bacteria. In the inflammation model, less body weight loss, macroscopic and histological damages in the large intestine were accompanied by increased IL-10/TNF-α ratio in the intestinal fluids of mice from the L. rhamnosus-TNBS group when compared to the TNBS group. In a healthy host, the oral administration of L. rhamnosus RC007 kept the gut immune system stimulated allowing a faster response to noxious stimulus. Mice that received L. rhamnosus RC007 also decreased the severity of the intestinal inflammation.

  16. Effects of Wet/Dry-Cycling and Plasma Treatments on the Properties of Flax Nonwovens Intended for Composite Reinforcing

    Directory of Open Access Journals (Sweden)

    Heura Ventura

    2016-02-01

    Full Text Available This research analyzes the effects of different treatments on flax nonwoven (NW fabrics which are intended for composite reinforcement. The treatments applied were of two different kinds: a wet/dry cycling which helps to stabilize the cellulosic fibers against humidity changes and plasma treatments with air, argon and ethylene gases considering different conditions and combinations, which produce variation on the chemical surface composition of the NWs. The resulting changes in the chemical surface composition, wetting properties, thermal stability and mechanical properties were determined. Variations in surface morphology could be observed by scanning electron microscopy (SEM. The results of the X-ray photoelectron spectroscopy (XPS showed significant changes to the surface chemistry for the samples treated with argon or air (with more content on polar groups on the surface and ethylene plasma (with less content of polar groups. Although only slight differences were found in moisture regain and water retention values (WRV, significant changes were found on the contact angle values, thus revealing hydrophilicity for the air-treated and argon-treated samples and hydrophobicity for the ethylene-treated ones. Moreover, for some of the treatments the mechanical testing revealed an increase of the NW breaking force.

  17. Manic tendencies are not related to being an entrepreneur, intending to become an entrepreneur, or succeeding as an entrepreneur.

    Science.gov (United States)

    Johnson, Sheri L; Freeman, Michael A; Staudenmaier, Paige J

    2015-03-01

    Popular literature suggests a relationship between entrepreneurship and manic tendencies, yet little scientific research has evaluated whether manic tendencies foster entrance into entrepreneurial roles, intent to become an entrepreneur, or success as an entrepreneur. In study 1, 225 undergraduates and business school students/affiliates took an online survey to assess engagement and intent as entrepreneurs, as well as manic tendencies, including family diagnoses as reported on the Family Index of Risk for Mania, subsyndromal manic tendencies as assessed with the Hypomanic Personality Scale, and self-reported diagnoses. In study 2, the sample of entrepreneurs identified in study 1 was enriched by recruiting a larger group of established entrepreneurs from the community. Entrepreneurs (n=210) completed items concerning their success in entrepreneurship, and we examined whether the three measures of manic tendencies were related to success. There was no evidence that those vulnerable to mania, regardless of definition, were more likely to be entrepreneurs, to intend to become entrepreneurs, or to succeed as entrepreneurs. The studies were limited by self-report measures and relatively small samples. More nuanced models may explain the frequent clinical observations of manic traits among entrepreneurs. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. The Role of Intended Audience in Determining Modality Type: A Study in Relation to the Iranian Constitution

    Directory of Open Access Journals (Sweden)

    Mahmood Naghizadeh

    2015-12-01

    Full Text Available Language, as a means of communication, offers its speakers some tools by which they can convey the meanings they intend to. One of these tools is the use of modals. Modals help the speakers to express their attitudes and opinions, regarding what is going on in a sentence. Epistemic modality deals with possibility and prediction and deontic modality concerns permission and obligation. This study aims to figure out whether Iranian constitution, as a sample of the laws set by the governments, seems likely more to convey the sense of obligation and permission to the audience(applying deontic modality,or the writers of these laws are just narrating a piece of information. For this purpose, the frequency of each modal type within Iranian constitution is evaluated and considered as an indicator of the writers' attitudes. Modal verbs, auxiliary modals and adverbs in the text of Iranian constitution are analyzed and different types and subtypes of modals are distinguished. The results have shown that in 83% of the applied modals, the spirit of permission and obligation for implementing these laws is very crucially and fully presented by the tool of deontic modality which is used for such purposes. Most of these obligations target the government and the permissions are mostly dedicated to people.

  19. Vitamin D concentrations in fortified foods and dietary supplements intended for infants: Implications for vitamin D intake.

    Science.gov (United States)

    Verkaik-Kloosterman, Janneke; Seves, S Marije; Ocké, Marga C

    2017-04-15

    Due to potential overages to cover losses during shelf life, the actual vitamin D concentration of fortified foods and dietary supplements may deviate from the label. In this pilot study the vitamin D concentrations of fortified foods (n=29; follow-on formula, baby porridge, curd cheese dessert) and dietary supplements (n=15), both specifically intended for infants, were analytically determined. Compared to the declared values, the vitamin D content ranged from 50% to 153% for fortified foods and from 8% to 177% for supplements. In general, both instant follow-on formula and oil-based supplements had a measured vitamin D content similar to or higher than the labelled value. Ready-to-eat baby porridge was the only category in which all measured vitamin D concentrations were below the declared value (74-81%). The use of label information for fortified foods and dietary supplements may result in invalid estimations of vitamin D intake distributions of infants; both under- and overestimation may occur.

  20. Precipitation effects on the selection of suitable non-variant targets intended for atmospheric correction of satellite remotely sensed imagery

    Science.gov (United States)

    Themistocleous, Kyriacos; Hadjimitsis, Diofantos G.; Retalis, Adrianos; Chrysoulakis, Nektarios; Michaelides, Silas

    2013-09-01

    One of the most well-established atmospheric correction methods of satellite imagery is the use of the empirical line method using non-variant targets. Non-variant targets serve as pseudo-invariant targets since their reflectance values are stable across time. A recent adaptation of the empirical line method incorporates the use of ground reflectance measurements of selected non-variant targets. Most of the users are not aware of the existing conditions of the pseudo-invariant targets; i.e., whether they are dry or wet. Any omission of such effects may cause erroneous results; therefore, remote sensing users must be aware of such effects. This study assessed the effects of precipitation on five types of commonly located surfaces, including asphalt, concrete and sand, intended as pseudo-invariant targets for atmospheric correction. Spectroradiometric measurements were taken in wet and dry conditions to obtain the spectral signatures of the targets, from January 2010 to May 2011 (46 campaigns). An atmospheric correction of eleven Landsat TM/ETM + satellite images using the empirical line method was conducted. To identify the effects of precipitation, a comparison was conducted of the atmospheric path radiance component for wet and dry conditions. It was found that precipitation conditions such as rainfall affected the reflectance values of the surfaces, especially sand. Therefore, precipitation conditions need to be considered when using non-variant targets in atmospheric correction methods.

  1. Intended long term performances of cementitious engineered barriers for future storage and disposal facilities for radioactive wastes in Romania

    Directory of Open Access Journals (Sweden)

    Sociu F.

    2013-07-01

    Full Text Available Considering the EU statements, Romania is engaged to endorse in the near future the IAEA relevant publications on geological repository (CNCANa, to update the Medium and Long Term National Strategy for Safe Management of Radioactive Waste and to approve the Road Map for Geological Repository Development. Currently, for example, spent fuel is wet stored for 6 years and after this period it is transported to dry storage in MACSTOR-200 (a concrete monolithic module where it is intended to remain at least 50 years. The present situation for radioactive waste management in Romania is reviewed in the present paper. Focus will be done on existent disposal facilities but, also, on future facilities planned for storage / disposal of radioactive wastes. Considering specific data for Romanian radioactive waste inventory, authors are reviewing the advance in the radioactive waste management in Romania considering its particularities. The team tries to highlight the expected limitations and unknown data related with cementitious engineered barriers that has to be faced in the near future incase of interim storage or for the upcoming long periods of disposal.

  2. Intended long term performances of cementitious engineered barriers for future storage and disposal facilities for radioactive wastes in Romania

    Science.gov (United States)

    Fako, R.; Barariu, Gh.; Toma, R.; Georgescu, R.; Sociu, F.

    2013-07-01

    Considering the EU statements, Romania is engaged to endorse in the near future the IAEA relevant publications on geological repository (CNCANa), to update the Medium and Long Term National Strategy for Safe Management of Radioactive Waste and to approve the Road Map for Geological Repository Development. Currently, for example, spent fuel is wet stored for 6 years and after this period it is transported to dry storage in MACSTOR-200 (a concrete monolithic module) where it is intended to remain at least 50 years. The present situation for radioactive waste management in Romania is reviewed in the present paper. Focus will be done on existent disposal facilities but, also, on future facilities planned for storage / disposal of radioactive wastes. Considering specific data for Romanian radioactive waste inventory, authors are reviewing the advance in the radioactive waste management in Romania considering its particularities. The team tries to highlight the expected limitations and unknown data related with cementitious engineered barriers that has to be faced in the near future incase of interim storage or for the upcoming long periods of disposal.

  3. Tabula diptycha: differential HIV knowledge, stigma and intended behavioural outcomes amongst visitors at Vietnam's Pain and Hope exhibition.

    Science.gov (United States)

    Nambiar, Devaki; Nguyen, Mai Huong; Giang, Le Minh; Hirsch, Jennifer; Parker, Richard G

    2013-01-01

    Stigma reduction efforts in Vietnam have been encumbered by contradictory and dynamic views of people living with HIV and the epidemic over the past two decades. World AIDS Day 2010 saw the launch of Pain and Hope, a museum exhibition showcasing the lives and experiences of Vietnamese people living with AIDS at the Vietnam Museum of Ethnology (VME). Between December 2010 and May 2011, a random sample of visitors completed exit surveys regarding their attitudes towards the exhibition and Vietnamese living with HIV/AIDS. The survey sought to determine what kind of visitors the museum and exhibition attracted, and the stigma-related impacts of this kind of exposure and parasocial contact. Of 2500 Vietnamese visitors randomly selected, 852 completed the computer surveys (response rate of 34.1%), 92.3% of whom had seen Pain and Hope. We found two sub-strata or types of visitors attending the exhibition, with varying demographic characteristics, HIV-related knowledge, some differences in stigma ideation, and clear differences in intended behaviours specifically attributable to the exhibition. Social desirability biases notwithstanding, there has emerged a diptych typology of visitors to the VME, for whom the experience of the exhibition is likely interacting with divergent prior knowledge, experiences, interests and motivations.

  4. 78 FR 22593 - The United States Advisory Commission on Public Diplomacy Notice of Charter Renewal

    Science.gov (United States)

    2013-04-16

    ... United States Advisory Commission on Public Diplomacy Notice of Charter Renewal The Department of State has renewed the charter of the United States Advisory Commission on Public Diplomacy. The Commission... public diplomacy activities (activities intended to understand, inform, and influence foreign...

  5. Agricultural Mechanics Unit for Plant Science Core Curriculum. Volume 15, Number 4. Instructor's Guide.

    Science.gov (United States)

    Linhardt, Richard E.; Hunter, Bill

    This instructor's guide is intended for use in teaching the agricultural mechanics unit of a plant science core curriculum. Covered in the individual units of the guide are the following topics: arc welding (following safety procedures, controlling distortion, selecting and caring for electrodes, identifying the material to be welded, and welding…

  6. Health Occupations Curriculum. Skills and Theory for Health Assistant. Volume I, Units 1-4.

    Science.gov (United States)

    Arizona State Dept. of Education, Phoenix.

    This volume consists of the first four units of a basic core curriculum that is intended for all health workers. The units deal with the following topics: (1) the health care facility, the long-term care facility, the health team, and the nursing team; (2) verbal and nonverbal communication, written communication, human behavior, ethical behavior,…

  7. Health Occupations Curriculum. Skills and Theory for Health Assistant. Volume 2, Units 5-7.

    Science.gov (United States)

    Arizona State Dept. of Education, Phoenix.

    This volume consists of three units of a basic core curriculum that is intended for all health workers. Covered in the units are the following topics: (1) the body's need for food, the effect of food on the body, the five food groups, the six nutrients, and therapeutic diets; (2) general principles of asepsis, specific methods of maintaining…

  8. Unit: Micro-Organisms and Man, Inspection Pack, National Trial Print.

    Science.gov (United States)

    Australian Science Education Project, Toorak, Victoria.

    This unit, intended for students in grades eight or nine, is a revised version of ED 053 990. The teacher's guide lists the aims of the unit, behavioral objectives, suitable references and audio-visual aids, required apparatus and materials, and provides teaching notes for each activity, including comments concerning microbiological techniques.…

  9. Alien Contact!: Exploring Teacher Implementation of an Augmented Reality Curricular Unit

    Science.gov (United States)

    Mitchell, Rebecca

    2011-01-01

    This paper reports on findings from a five-teacher, exploratory case study, critically observing their implementation of a technology-intensive, augmented reality (AR) mathematics curriculum unit, along with its paper-based control. The unit itself was intended to promote multiple proportional-reasoning strategies with urban, public, middle school…

  10. Learning Resource Units for Young Children: A Curriculum for Preschool Children.

    Science.gov (United States)

    McIntyre, Karen S., Comp.

    These learning resource units are based on the philosophy and goals for early childhood education which have been established for the school district of Pittsburgh. They are intended to assist teachers in planning for preschool children's educational experience. Activities in the learning resource units should be selected in response to children's…

  11. Careers (A Course of Study). Unit VIII: Budgeting--What to Do With Your Paycheck.

    Science.gov (United States)

    Turley, Kay

    Designed to enable special needs students to understand the basics of personal income management, normal living expenses, banking, and comparison shopping, this set of activities on budgeting is the eighth unit in a nine-unit secondary level career course intended to provide handicapped students with the knowledge and tools necessary to succeed in…

  12. Careers (A Course of Study). Unit IV: Applying for the Job.

    Science.gov (United States)

    Turley, Kay

    Designed to enable special needs students to write resumes and complete application forms with employable accuracy, this set of activities on applying for a job is the fourth unit in a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world of work. Chapter 1…

  13. Careers (A Course of Study). Unit VI: Interviewing for the Job.

    Science.gov (United States)

    Turley, Kay

    Designed to enable special needs students to arrange, complete, and follow up a job interview, this set of activities on job interviews is the sixth unit in a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world of work. The eight activities in the first…

  14. Termination unit

    Energy Technology Data Exchange (ETDEWEB)

    Traeholt, Chresten; Willen, Dag; Roden, Mark; Tolbert, Jerry C.; Lindsay, David; Fisher, Paul W.; Nielsen, Carsten Thidemann

    2016-05-03

    Cable end section comprises end-parts of N electrical phases/neutral, and a thermally-insulation envelope comprising cooling fluid. The end-parts each comprises a conductor and are arranged with phase 1 innermost, N outermost surrounded by the neutral, electrical insulation being between phases and N and neutral. The end-parts comprise contacting surfaces located sequentially along the longitudinal extension of the end-section. A termination unit has an insulating envelope connected to a cryostat, special parts at both ends comprising an adapter piece at the cable interface and a closing end-piece terminating the envelope in the end-section. The special parts houses an inlet and/or outlet for cooling fluid. The space between an inner wall of the envelope and a central opening of the cable is filled with cooling fluid. The special part at the end connecting to the cryostat houses an inlet or outlet, splitting cooling flow into cable annular flow and termination annular flow.

  15. Configurations of Leadership Practices in Hospital Units

    DEFF Research Database (Denmark)

    Meier, Ninna

    2015-01-01

    shows leadership practices to be primarily embedded in the clinical work and often shared across organizational or professional boundaries. Originality/value: – This paper demonstrated how leadership practices are embedded in the everyday work in hospital units. Moreover, the analysis shows how...... and interviews with ten interdisciplinary clinical managers. Findings: – Comparing leadership as configurations of practices across four different clinical settings, the author shows how flexible and often shared leadership practices were embedded in and central to the core clinical work in all units studied...

  16. 1:1,000,000-Scale Streams of the United States - Direct Download

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map layer shows streams of the United States, Puerto Rico, and the U.S. Virgin Islands. The map layer was produced primarily from the Medium-Resolution and...

  17. [End of the borders? Undocumented migration from Mexico to the United States].

    Science.gov (United States)

    Castillo, D

    1993-01-01

    This is an analysis of trends in illegal labor migration between Mexico and the United States from 1924 to 1986. Data are primarily from the 1984 Encuesta a Trabajadores Indocumentados Devueltos de Estados Unidos, supplemented by more recent studies.

  18. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.

    Directory of Open Access Journals (Sweden)

    Belén Picatoste

    Full Text Available BACKGROUND: Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1 enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart. METHODS: Goto-Kakizaki (GK rats developed type-II diabetes and received sitagliptin, an anti-hyperglycemic drug (metformin or vehicle (n=10, each. After cardiac structure and function assessment, plasma and left ventricles were isolated for biochemical studies. Cultured cardiomyocytes and fibroblasts were used for in vitro assays. RESULTS: Untreated GK rats exhibited hyperglycemia, hyperlipidemia, plasma GLP-1 decrease, and cardiac cell-death, hypertrophy, fibrosis and prolonged deceleration time. Moreover, cardiac pro-apoptotic/necrotic, hypertrophic and fibrotic factors were up-regulated. Importantly, both sitagliptin and metformin lessened all these parameters. In cultured cardiomyocytes and cardiac fibroblasts, high-concentration of palmitate or glucose induced cell-death, hypertrophy and fibrosis. Interestingly, GLP-1 and its insulinotropic-inactive metabolite, GLP-1(9-36, alleviated these responses. In addition, despite a specific GLP-1 receptor was only detected in cardiomyocytes, GLP-1 isoforms attenuated the pro-fibrotic expression in cardiomyocytes and fibroblasts. In addition, GLP-1 receptor signalling may be linked to PPARδ activation, and metformin may also exhibit anti-apoptotic/necrotic and anti-fibrotic direct effects in cardiac cells. CONCLUSIONS: Sitagliptin, via GLP-1 stabilization, promoted cardioprotection in type-II diabetic hearts primarily by limiting hyperglycemia e hyperlipidemia. However, GLP-1 and GLP-1(9-36 promoted survival and anti-hypertrophic/fibrotic effects on cultured cardiac cells, suggesting cell-autonomous cardioprotective actions.

  19. Maternal Exposure to Valproic Acid Primarily Targets Interneurons Followed by Late Effects on Neurogenesis in the Hippocampal Dentate Gyrus in Rat Offspring.

    Science.gov (United States)

    Watanabe, Yousuke; Murakami, Tomoaki; Kawashima, Masashi; Hasegawa-Baba, Yasuko; Mizukami, Sayaka; Imatanaka, Nobuya; Akahori, Yumi; Yoshida, Toshinori; Shibutani, Makoto

    2017-01-01

    Valproic acid (VPA) is used to establish models of experimental autism. The present study investigated the developmental exposure effect of VPA on postnatal hippocampal neurogenesis in accordance with the exposure scheme of OECD Test Guideline 426 adopted for developmental neurotoxicity. Pregnant rats were administered drinking water containing 0, 667, or 2000 ppm VPA from gestational day 6 until day 21 post-delivery. In the subgranular zone (SGZ) and granule cell layer (GCL) of offspring, the number of granule cell lineage subpopulations remained unchanged upon weaning. However, in the hilus of the dentate gyrus, the number of reelin(+) interneurons decreased at ≥667 ppm, and the number of PVALB(+) or GAD67(+) interneurons decreased at 2000 ppm. Conversely, Reln and Gad1 transcript levels increased at 2000 ppm, but Pvalb and Grin2d decreased, in the dentate gyrus. At the adult stage, PCNA(+) proliferating SGZ cells, NeuN(+) postmitotic SGZ/GCL neurons, and ARC(+) or COX2(+) GCL neurons increased at ≥667 ppm. In the dentate hilus, decreases in GAD67(+) interneuron subpopulations and Grin2d transcript levels sustained at 2000 ppm. These results suggested that VPA primarily targets interneurons by developmental exposure, and this is followed by late effects on granule cell lineages, likely by influencing SGZ cell proliferation and synaptic plasticity. A reduced population of reelin(+) or PVALB(+) interneurons did not affect distribution of granule cell lineage subpopulations upon weaning. The late effect on neurogenesis, which resulted in increased GCL neurons, might be the result of a sustained decrease in GAD67(+) interneurons expressing NR2D encoded by Grin2d.

  20. Quantity of dietary protein intake, but not pattern of intake, affects net protein balance primarily through differences in protein synthesis in older adults.

    Science.gov (United States)

    Kim, Il-Young; Schutzler, Scott; Schrader, Amy; Spencer, Horace; Kortebein, Patrick; Deutz, Nicolaas E P; Wolfe, Robert R; Ferrando, Arny A

    2015-01-01

    To examine whole body protein turnover and muscle protein fractional synthesis rate (MPS) following ingestions of protein in mixed meals at two doses of protein and two intake patterns, 20 healthy older adult subjects (52-75 yr) participated in one of four groups in a randomized clinical trial: a level of protein intake of 0.8 g (1RDA) or 1.5 g·kg(-1)·day(-1) (∼2RDA) with uneven (U: 15/20/65%) or even distribution (E: 33/33/33%) patterns of intake for breakfast, lunch, and dinner over the day (1RDA-U, 1RDA-E, 2RDA-U, or 2RDA-E). Subjects were studied with primed continuous infusions of L-[(2)H5]phenylalanine and L-[(2)H2]tyrosine on day 4 following 3 days of diet habituation. Whole body protein kinetics [protein synthesis (PS), breakdown, and net balance (NB)] were expressed as changes from the fasted to the fed states. Positive NB was achieved at both protein levels, but NB was greater in 2RDA vs. 1RDA (94.8 ± 6.0 vs. 58.9 ± 4.9 g protein/750 min; P = 0.0001), without effects of distribution on NB. The greater NB was due to the higher PS with 2RDA vs. 1RDA (15.4 ± 4.8 vs. -18.0 ± 8.4 g protein/750 min; P = 0.0018). Consistent with PS, MPS was greater with 2RDA vs. 1RDA, regardless of distribution patterns. In conclusion, whole body net protein balance was greater with protein intake above recommended dietary allowance (0.8 g protein·kg(-1)·day(-1)) in the context of mixed meals, without demonstrated effects of protein intake pattern, primarily through higher rates of protein synthesis at whole body and muscle levels.

  1. Perturbation of the natural killer cell compartment during primary human immunodeficiency virus 1 infection primarily involving the CD56bright subset

    Science.gov (United States)

    Mantegani, Paola; Tambussi, Giuseppe; Galli, Laura; Din, Chiara Tassan; Lazzarin, Adriano; Fortis, Claudio

    2010-01-01

    We investigated the distribution of natural killer (NK) cell subsets, their activating and inhibitory receptors, and their cytolytic potential, in primary human immunodeficiency virus (HIV)-infected (PHI) individuals at baseline and during 1 year of follow-up with or without antiretroviral therapy, and compared the results with those obtained in treatment-naïve, chronically HIV-infected (CHI) individuals, and HIV-seronegative (HN) healthy individuals. The proportion of the CD56dim and CD56bright subsets decreased with disease progression, whereas that of the CD56− CD16+ subset increased. In the CD56dim subset, the proportion of cells with natural cytotoxicity receptors (NCRs) decreased with disease progression, and their cytolytic potential was reduced. Conversely, the CD56bright subset was characterized by a high proportion of NCR-positive, killer cell immunoglobulin-like receptor (KIR)-positive NKG2A+ cells in both CHI and PHI individuals, which was associated with an increase in their cytolytic potential. During the 1 year of follow-up, the PHI individuals with high viraemia levels and low CD4+ T-cell counts who received highly active antiretroviral therapy (HAART) had a similar proportion of NK subsets to CHI individuals, while patients with low viraemia levels and high CD4+ T-cell counts who remained untreated had values similar to those of the HN individuals. Our results indicate a marked perturbation of the NK cell compartment during HIV-1 infection that is multifaceted, starts early and is progressive, primarily involves the CD56bright subset, and is partially corrected by effective HAART. PMID:19824914

  2. Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.

    Science.gov (United States)

    Lu, Richard; Limón, Ana; Devroe, Eric; Silver, Pamela A; Cherepanov, Peter; Engelman, Alan

    2004-12-01

    Integrase has been implicated in human immunodeficiency virus type 1 (HIV-1) nuclear import. Integrase analyses, however, can be complicated by the pleiotropic nature of mutations: whereas class I mutants are integration defective, class II mutants display additional assembly and/or reverse transcription defects. We previously determined that HIV-1(V165A), originally reported as defective for nuclear import, was a class II mutant. Here we analyzed mutants containing changes in other putative nuclear localization signals, including (186)KRK(188)/(211)KELQKQITK(219) and Cys-130. Previous work established HIV-1(K186Q), HIV-1(Q214L/Q216L), and HIV-1(C130G) as replication defective, but phenotypic classification was unclear and nuclear import in nondividing cells was not addressed. Consistent with previous reports, most of the bipartite mutants studied here were replication defective. These mutants as well as HIV-1(V165A) synthesized reduced cDNA levels, but a normal fraction of mutant cDNA localized to dividing and nondividing cell nuclei. Somewhat surprisingly, recombinant class II mutant proteins were catalytically active, and class II Vpr-integrase fusion proteins efficiently complemented class I mutant virus. Since a class I Vpr-integrase mutant efficiently complemented class II mutant viruses under conditions in which class II Vpr-integrases failed to function, we conclude that classes I and II define two distinct complementation groups and suggest that class II mutants are primarily defective at a postnuclear entry step of HIV-1 replication. HIV-1(C130G) was also defective for reverse transcription, but Vpr-integrase(C130G) did not efficiently complement class I mutant HIV-1. Since HIV-1(C130A) grew like the wild type, we conclude that Cys-130 is not essential for replication and speculate that perturbation of integrase structure contributed to the pleiotropic HIV-1(C130G) phenotype.

  3. (-)Deprenyl and (-)1-phenyl-2-propylaminopentane, [(-)PPAP], act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons.

    Science.gov (United States)

    Knoll, J; Miklya, I; Knoll, B; Markó, R; Kelemen, K

    1996-01-01

    The activity of the catecholaminergic neurons in the rat brain is enhanced significantly 30 min after the subcutaneous injection of very small doses of (-)deprenyl (threshold doses: 0.01 mg/kg for noradrenergic neurons and 0.025 mg/kg for dopaminergic neurons). As a catecholaminergic activity enhancer (CAE) substance (-)deprenyl is about ten times more potent than its parent compound, (-)methamphetamine. While the (+)methamphetamine is 3-5 times more potent than (-)methamphetammine in releasing catecholamines, the (-)methamphetamine is the more potent CAE substance. The mechanism of the CAE effect of (-)deprenyl and (-)PPAP, a deprenyl-derived substance devoid of MAO inhibitory potency, was studied in rats by measuring: a) the release of catecholamines from striatum, substantia nigra, tuberculum olfactorium and locus coeruleus; b) the stimulation induced release of 3H-noradrenaline from the isolated brain stem; and c) the antagonistic effect against tetrabenazine-induced depression of learning in the shuttle box. The CAE effect was found to be unrelated: a) to the inhibition of MAO activity; b) to the inhibition of presynaptic catecholamine receptors; c) to the inhibition of the uptake of catecholamines; and d) to the release of catecholamines. It was concluded that (-)deprenyl and (-)PPAP act primarily as potent stimulants of action potential-transmitter release coupling in the catecholaminergic neurons of the brain. We show that both (-)deprenyl and (-)PPAP enhance the inward Ca2+ current in sino-auricular fibers of the frog heart. (-)PPAP was much more potent than either (+)PPAP or (-)deprenyl in this test.

  4. The elevation of apoB in hypercholesterolemic patients is primarily attributed to the relative increase of apoB/Lp-PLA₂.

    Science.gov (United States)

    Tellis, Constantinos C; Moutzouri, Eliza; Elisaf, Moses; Wolfert, Robert L; Tselepis, Alexandros D

    2013-12-01

    Lipoprotein-associated phospholipase A₂ (Lp-PLA₂) is a risk factor of cardiovascular disease. Plasma Lp-PLA₂ is mainly associated with apolipoprotein (apo)B-containing lipoproteins, primarily with low density lipoproteins (LDLs). Importantly, only a proportion of circulating lipoproteins contain Lp-PLA₂. We determined the plasma levels of Lp-PLA₂-bound apoB (apoB/Lp-PLA₂) in patients with primary hypercholesterolemia. The effect of simvastatin therapy was also addressed. The plasma apoB/Lp-PLA₂ concentration in 50 normolipidemic controls and 53 patients with primary hypercholesterolemia at baseline and at 3 months posttreatment with simvastatin (40 mg/day) was determined by an enzyme-linked immunosorbent assay. The concentration of the apoB-containing lipoproteins that do not bind Lp-PLA₂ [apoB/Lp-PLA₂⁻] was calculated by subtracting the apoB/Lp-PLA₂ from total apoB. The apoB/Lp-PLA₂ levels were 3.6-fold higher, while apoB/Lp-PLA₂⁻ were 1.3-fold higher in patients compared with controls. After 3 months of simvastatin treatment apoB/Lp-PLA₂ and apoB/Lp-PLA₂⁻ levels were reduced by 52% and 33%, respectively. The elevation in apoB-containing lipoproteins in hypercholesterolemic patients is mainly attributed to the relative increase in the proatherogenic apoB/Lp-PLA₂, while simvastatin reduces these particles to a higher extent compared with apoB/Lp-PLA₂⁻. Considering that Lp-PLA₂ is proatherogenic, the predominance of apoB/Lp-PLA₂ particles in hypercholesterolemic patients may contribute to their higher atherogenicity and incidence of cardiovascular disease.

  5. Prostaglandin (PG) E3 synthesis elicted by adrenergic stimuli in guinea-pig trachea (GPT) is mediated primarily by B2 adrenergic receptors

    Energy Technology Data Exchange (ETDEWEB)

    Nadel, G.L.; Malik, K.U.; Lew, D.B. (Univ. of Tennessee, Memphis (United States))

    1990-02-26

    The purpose of this study was to examine arachidonic acid (AA) metabolism and to characterize the type of adrenergic receptor (AR) involved in the production of the major metabolite of this fatty acid. ({sup 14}C)AA was incubated with GPT-rings and the radiolabelled products were extracted and separated by TLC method. The medium was also assayed for radiolabelled immunoreactive PG's (iPG's) and leukotrienes (LT) B4 and C4 by RIA or Enzyme immunoassay (EIA) after exposure to various AR agonists. ({sup 14}C)AA was incorporated into GPT-rings and metabolized mainly into iPGE2 and smaller amounts into PGF2{alpha}. Trace amounts of PGD2 and 6-keto-PGF1{alpha} but not LTB4 or LTC4 were detected by RIA and/or EIA. Incubation of GPT rings for 15 minutes with isoproterenol and salbutamol resulted in a significant increase of PGE2 synthesis (optimum conc: 10{sup {minus}7}, 10{sup {minus}7}M respectively). In contrast, dobutamine, norepinephrine, phenylnephrine and xylazine (up to 10{sup {minus}6}M) did not significantly increase PGE2 production. Isoproterenol-induced iPGE2 production was inhibited by a selective {beta}2 antagonist, butoxamine (70%: 10{sup {minus}7}M, 91%: 10{sup {minus}6}M) and somewhat reduced by {beta}1 antagonists practolol and metoprolol (30-64%:10{sup {minus}6}M). These data suggest that isoproterenol induced iPGE2 synthesis is primarily mediated via activation of {beta}2 adrenergic receptor.

  6. Water deficit in field-grown Gossypium hirsutum primarily limits net photosynthesis by decreasing stomatal conductance, increasing photorespiration, and increasing the ratio of dark respiration to gross photosynthesis.

    Science.gov (United States)

    Chastain, Daryl R; Snider, John L; Collins, Guy D; Perry, Calvin D; Whitaker, Jared; Byrd, Seth A

    2014-11-01

    Much effort has been expended to improve irrigation efficiency and drought tolerance of agronomic crops; however, a clear understanding of the physiological mechanisms that interact to decrease source strength and drive yield loss has not been attained. To elucidate the underlying mechanisms contributing to inhibition of net carbon assimilation under drought stress, three cultivars of Gossypium hirsutum were grown in the field under contrasting irrigation regimes during the 2012 and 2013 growing season near Camilla, Georgia, USA. Physiological measurements were conducted on three sample dates during each growing season (providing a broad range of plant water status) and included, predawn and midday leaf water potential (ΨPD and ΨMD), gross and net photosynthesis, dark respiration, photorespiration, and chlorophyll a fluorescence. End-of-season lint yield was also determined. ΨPD ranged from -0.31 to -0.95MPa, and ΨMD ranged from -1.02 to -2.67MPa, depending upon irrigation regime and sample date. G. hirsutum responded to water deficit by decreasing stomatal conductance, increasing photorespiration, and increasing the ratio of dark respiration to gross photosynthesis, thereby limiting PN and decreasing lint yield (lint yield declines observed during the 2012 growing season only). Conversely, even extreme water deficit, causing a 54% decline in PN, did not negatively affect actual quantum yield, maximum quantum yield, or photosynthetic electron transport. It is concluded that PN is primarily limited in drought-stressed G. hirsutum by decreased stomatal conductance, along with increases in respiratory and photorespiratory carbon losses, not inhibition or down-regulation of electron transport through photosystem II. It is further concluded that ΨPD is a reliable indicator of drought stress and the need for irrigation in field-grown cotton.

  7. HIV/AIDS stigma among a sample of primarily African-American and Latino men who have sex with men social media users.

    Science.gov (United States)

    Garett, Renee; Smith, Justin; Chiu, Jason; Young, Sean D

    2016-01-01

    The recent increase in social media use allows these technologies to rapidly reach communities with higher HIV prevalence, such as African-American and Latino men who have sex with men (MSM). However, no studies have looked at HIV/AIDS stigma among social media users from African-American and Latino MSM communities, or the association between stigma and social media use among these groups. This study sought to assess the level of HIV/AIDS stigma among a sample of social media-using African-American and Latino MSM from Los Angeles. A total of 112 (primarily African-American and Latino, n = 98, 88%) MSM Facebook users completed a survey on demographics, online social network use, and HIV/AIDS stigma. A composite stigma score was created by taking the cumulative score from a 15-item stigma questionnaire. Cumulative logistic models were used to assess the association between HIV/AIDS stigma and online social network use. In general, participants reported a low level of HIV/AIDS stigma (mean = 22.2/75, SD = 5.74). HIV/AIDS stigma composite score was significantly associated with increased time spent on online social networks each day (Adjusted odds ratios (AOR): 1.07, 95% CI: 1.00, 1.15). Among this diverse sample of MSM online social network users, findings suggest that HIV/AIDS stigma is associated with usage of social media. We discuss the implications of this work for future HIV prevention.

  8. Model-Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms.

    Science.gov (United States)

    Reinecke, Isabel; Schultze-Mosgau, Marcus-Hillert; Nave, Rüdiger; Schmitz, Heinz; Ploeger, Bart A

    2017-05-01

    Pharmacokinetics (PK) of anastrozole (ATZ) and levonorgestrel (LNG) released from an intravaginal ring (IVR) intended to treat endometriosis symptoms were characterized, and the exposure-response relationship focusing on the development of large ovarian follicle-like structures was investigated by modeling and simulation to support dose selection for further studies. A population PK analysis and simulations were performed for ATZ and LNG based on clinical phase 1 study data from 66 healthy women. A PK/PD model was developed to predict the probability of a maximum follicle size ≥30 mm and the potential contribution of ATZ beside the known LNG effects. Population PK models for ATZ and LNG were established where the interaction of LNG with sex hormone-binding globulin (SHBG) as well as a stimulating effect of estradiol on SHBG were considered. Furthermore, simulations showed that doses of 40 μg/d LNG combined with 300, 600, or 1050 μg/d ATZ reached anticipated exposure levels for both drugs, facilitating selection of ATZ and LNG doses in the phase 2 dose-finding study. The main driver for the effect on maximum follicle size appears to be unbound LNG exposure. A 50% probability of maximum follicle size ≥30 mm was estimated for 40 μg/d LNG based on the exposure-response analysis. ATZ in the dose range investigated does not increase the risk for ovarian cysts as occurs with LNG at a dose that does not inhibit ovulation. © 2016, The American College of Clinical Pharmacology.

  9. Soil quality is key for planning and managing urban allotments intended for the sustainable production of home-consumption vegetables.

    Science.gov (United States)

    Bretzel, F; Calderisi, M; Scatena, M; Pini, R

    2016-09-01

    The growing importance of urban allotments in planning and managing urban areas is due to the combined positive effects on ecosystem services, the economy and human well-being, especially of groups of the urban population that can be vulnerable (e.g. the elderly, immigrants, low-income families). Some studies have highlighted the potential risk of contamination by metals of vegetables grown in urban areas and the lack of appropriate site-specific risk assessments. However, surveys are still lacking on the possibilities of using urban soil as a good substrate to produce vegetables for home consumption. We assessed the soil quality in two areas in Pisa (Italy), one intended for urban horticulture and the other already cultivated for that purpose. We analysed the soils for the main chemical and physical characteristics (texture, bulk density, water stability index, pH, cation exchange capacity, organic carbon, total nitrogen, phosphorous) and elements (Pb, Cu, Ni, Cr, Zn, Cd, As, K, Al and Mn). Our results showed that both areas had physical and chemical heterogeneity due to the effects of urbanization and to the different cultivation techniques employed. The metal content was lower than the guidelines limits, and the soil conditions (pH = 8) greatly reduced the metal mobility. Copper concentration in some of the cultivated area samples was higher than the limits, representing a possible stress factor for the microbial biodiversity and fauna. Our findings demonstrate that site-specific surveys are necessary before planning urban cultivation areas, and educating urban gardeners regarding sustainable cultivation techniques is a priority for a safe environment.

  10. Low-Power, Low-Voltage Electroosmotic Actuator for an Implantable Micropumping System Intended for Drug Delivery Applications

    Science.gov (United States)

    Getpreecharsawas, Jirachai

    An electroosmotic (EO) actuator offers a low-power, low-voltage alternative in a diaphragm-based periodic displacement micropump intended for an implantable drug delivery system. The actuator utilizes an electroosmosis mechanism to transport liquid across a membrane to deflect the pumping diaphragms in a reciprocating manner. In the study, the membrane made of porous nanocrystalline silicon (pnc-Si) tens of nanometers in thickness was used as the promising EO generator with low power consumption and small package size. This ultrathin membrane provides the opportunity for electrode integration such that the very high electric field can be generated across the membrane with the applied potential under 1 volt for low flow rate applications like drug delivery. Due to such a low applied voltage, the challenge, however, imposes on the capability of generating the pumping pressure high enough to deflect the pumping diaphragms and overcome the back pressure normally encountered in the biological tissue and organ. This research identified the cause of weak pumping pressure that the electric field inside the orifice-like nanopores of the ultrathin membrane is weaker than conventional theory would predict. It no longer scales uniformly with the thickness of membrane, but with the pore length-to-diameter aspect ratio for each nanopore. To enhance the pumping performance, the pnc-Si membrane was coated with an ultrathin Nafion film. As a result, the induced concentration difference across the Nafion film generates the osmotic pressure against the back pressure allowing the EO actuator to maintain the target pumping flow rate under 1 volt.

  11. The influence of crystallization conditions on the morphology of lactose intended for use as a carrier for dry powder aerosols.

    Science.gov (United States)

    Zeng, X M; Martin, G P; Marriott, C; Pritchard, J

    2000-06-01

    Lactose has been widely used as a carrier for inhalation aerosols. The carrier morphology is believed to affect the delivery of the drug. The aim of this study was to investigate the effects of crystallization conditions on the morphology of alpha-lactose monohydrate intended for use as the carrier for dry powder aerosols. The crystallization of lactose was carried out from aqueous solutions at different supersaturations, temperatures, different stages of crystallization and in the presence of different water-miscible organic solvents. The majority of lactose crystals were found to be either tomahawk-shaped or pyramidal after crystallization at an initial lactose concentration between 33-43% w/w, but these became prismatic if the lactose concentration was increased to 50% w/w. A further increase in the lactose concentration to 60% w/w led to the preparation of elongated cuboidal crystals. Higher initial lactose concentrations tended to result in the crystallization of more elongated particles. Crystallization at 40 degrees C was shown to prepare lactose crystals with a more regular shape and a smoother surface than those crystallized at 0 degrees C. Lactose particles generated during the later stage of crystallization were found to be more regular in shape with a smoother surface than those prepared in the earlier stage. The addition of 10% (v/v) methanol or ethanol or acetone to the mother liquor increased the growth rate of lactose particles whereas addition of propanol or glycerine inhibited the rate of crystal growth. Lactose crystals prepared in the presence of glycerine were more regularly shaped with a smoother surface than those prepared in the presence of ethanol or acetone. All the resultant crystals were shown to comprise alpha-lactose monohydrate. Lactose crystals could be prepared with a precisely defined morphology by means of carefully controlling the crystallization conditions.

  12. Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water.

    Science.gov (United States)

    Bou-Maroun, Elias; Dahbi, Laurence; Gomez-Berrada, Marie-Pierre; Pierre, Philippine; Rakotomalala, Sandrine; Ferret, Pierre-Jacques; Chagnon, Marie-Christine

    2017-10-25

    The objective of the work was to check the presence of Non-Intended Added Substances (NIAS) with hormonal activities in aluminium coatings extracts coded: AA, BBF, MC and RR, furnished by four different suppliers. Water samples were prepared at room temperature or at 40°C for three months to verify the storage effect on the coatings. Solid phase extraction was used to concentrate and to extract coating substances. Hormonal activities were checked in vitro using reporter gene bioassays. Except BBF, all extracts induced a weak but significant estrogenic agonist activity in the human cell line. Using an estrogenic antagonist (ICI-182, 780), the answer was demonstrated specific in the bioassay. RR was the only extract to induce a concentration dependent anti-androgenic response in the MDA-KB2 cell line. Analysis performed using GC-MS and HPLC-MS detected 12 substances in most of the extracts. 8 NIAS were present. Among them, 4 were identified with certainty: HMBT, BGA, DCU and BPA. Estrogenic potency was BPA>DCU>BGA>HMBT. HMBT was also anti-androgenic at high concentration. Combining chemical analysis and bioassays data, we demonstrated that in the RR and the RR40 extracts, the observed estrogenic response was mainly due to BPA, the anti-androgenic activity of RR could be due to a synergism between HMBT and BPA. For MC and AA, estrogenic responses appear to be due to the presence of DCU. Except BBF, storage conditions tended to increase estrogenic activities in all extracts. However, in term of risk assessment, activities observed were negligible. This work demonstrated that sensitive bioassays are pertinent tools in complement to chemical analysis to monitor and check the presence of NIAS with hormonal activity in coating extracts. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Back-of-pack information in substitutive food choices: A process-tracking study in participants intending to eat healthy.

    Science.gov (United States)

    van Buul, Vincent J; Bolman, Catherine A W; Brouns, Fred J P H; Lechner, Lilian

    2017-09-01

    People are increasingly aware of the positive effects of a healthy diet. Concurrently, daily food consumption decisions - choices about both the quality and quantity of food that is ingested - are steered more by what consumers consider healthy. Despite the increased aim to eat healthier, however, consumers often do not read or incorrectly interpret on-pack nutrition information, resulting in suboptimal food choices in terms of health. This study aims to unravel the determinants of such inadvertent food choices from these consumers. In an online process-tracking study, we measured the actual usage of available back-of-pack nutrition information during substitutive food choices made by 240 participants who had the intention to eat healthy. Using mouse-tracking software in a computerized task in which participants had to make dichotomous food choices (e.g., coconut oil or olive oil for baking), we measured the frequency and time of nutritional information considered. Combined with demographic and psychosocial data, including information on the level of intention, action planning, self-efficacy, and nutrition literacy, we were able to model the determinants of inadvertent unhealthy substitutive food choices in a sequential multiple regression (R(2) = 0.40). In these consumers who intended to eat healthy, the quantity of obtained nutrition information significantly contributed as an associative factor of the percentage of healthy food choices made. Moreover, the level of correct answers in a nutrition literacy test, as well as taste preferences, significantly predicted the percentage of healthier choices. We discuss that common psychosocial determinants of healthy behavior, such as intention, action planning, and self-efficacy, need to be augmented with a person's actual reading and understanding of nutrition information to better explain the variance in healthy food choice behavior. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Prenosna peć za pečenje hleba - u funkciji obezbeđenja ishrane pripadnika vojske Srbije u mirovnim misijama/Movable oven for bread baking intended for food preparation in Serbian army peace corps

    Directory of Open Access Journals (Sweden)

    Branko M. Tešanović

    2014-10-01

    Full Text Available Peć za pečenje hleba u poljskim uslovima dodeljuje se jedinicama koje su po svom karakteru relativno stacionarne i kojima po veličini ne bi pripadale pokretne peći. Podesna je za pečenje hleba namenjenog jedinicama koje se nalaze u međunarodnim misijama, u uslovima otežanog snabdevanja, jer navike naših vojnika su da konzumiraju hleb, a ne keks. Peć je montažno-demontažnog tipa, prilagođena za korišćenje na svim vrstama terena. Jednostavne je konstrukcije, što omogućava da se demontira i lako prenosi sa mesta na mesto. / An oven for baking bread in field conditions is assigned to units that are by their nature relatively stationary and whose size does not require a movable bakery. It is intended for baking bread in our units located in international missions with supply difficulties, since our units have a habit od consuming bread instead of biscuits. The oven is of a prefabricated type, adapted for use in all types of terrains, simple design which makes it possible to be, dismantled and easily transported.

  15. Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

    Directory of Open Access Journals (Sweden)

    Christina N. Kontoghiorghe

    2015-11-01

    Full Text Available Iron chelating drugs are primarily and widely used in the treatment of transfusional iron overload in thalassaemia and similar conditions. Recent in vivo and clinical studies have also shown that chelators, and in particular deferiprone, can be used effectively in many conditions involving free radical damage and pathology including neurodegenerative, renal, hepatic, cardiac conditions and cancer. Many classes of phytochelators (Greek: phyto (φυτό—plant, chele (χηλή—claw of the crab with differing chelating properties, including plant polyphenols resembling chelating drugs, can be developed for clinical use. The phytochelators mimosine and tropolone have been identified to be orally active and effective in animal models for the treatment of iron overload and maltol for the treatment of iron deficiency anaemia. Many critical parameters are required for the development of phytochelators for clinical use including the characterization of the therapeutic targets, ADMET, identification of the therapeutic index and risk/benefit assessment by comparison to existing therapies. Phytochelators can be developed and used as main, alternative or adjuvant therapies including combination therapies with synthetic chelators for synergistic and or complimentary therapeutic effects. The development of phytochelators is a challenging area for the introduction of new pharmaceuticals which can be used in many diseases and also in ageing. The commercial and other considerations for such development have great advantages in comparison to synthetic drugs and could also benefit millions of patients in developing countries.

  16. California Watershed Hydrologic Units

    Data.gov (United States)

    California Department of Resources — This dataset is intended to be used as a tool for water-resource management and planning activities, particularly for site-specific and localized studies requiring a...

  17. Design and Calibration of a Raman Spectrometer for use in a Laser Spectroscopy Instrument Intended to Analyze Martian Surface and Atmospheric Characteristics for NASA

    Science.gov (United States)

    Lucas, John F.; Hornef, James

    2016-01-01

    This project's goal is the design of a Raman spectroscopy instrument to be utilized by NASA in an integrated spectroscopy strategy that will include Laser-Induced Breakdown Spectroscopy (LIBS) and Laser-Induced Florescence Spectroscopy (LIFS) for molecule and element identification on Mars Europa, and various asteroids. The instrument is to be down scaled from a dedicated rover mounted instrument into a compact unit with the same capabilities and accuracy as the larger instrument. The focus for this design is a spectrometer that utilizes Raman spectroscopy. The spectrometer has a calculated range of 218 nm wavelength spectrum with a resolution of 1.23 nm. To filter out the laser source wavelength of 532 nm the spectrometer design utilizes a 532 nm wavelength dichroic mirror and a 532 nm wavelength notch filter. The remaining scatter signal is concentrated by a 20 x microscopic objective through a 25-micron vertical slit into a 5mm diameter, 1cm focal length double concave focusing lens. The light is then diffracted by a 1600 Lines per Millimeter (L/mm) dual holographic transmission grating. This spectrum signal is captured by a 1-inch diameter double convex 3 cm focal length capture lens. An Intensified Charge Couple Device (ICCD) is placed within the initial focal cone of the capture lens and the Raman signal captured is to be analyzed through spectroscopy imaging software. This combination allows for accurate Raman spectroscopy to be achieved. The components for the spectrometer have been bench tested in a series of prototype developments based on theoretical calculations, alignment, and scaling strategies. The mounting platform is 2.5 cm wide by 8.8 cm long by 7 cm height. This platform has been tested and calibrated with various sources such as a neon light source and ruby crystal. This platform is intended to be enclosed in a ruggedized enclosure for mounting on a rover platform. The size and functionality of the Raman spectrometer allows for the rover to

  18. Histopathological variables and biomarkers enhancer of zeste homologue 2, Ki-67 and minichromosome maintenance protein 7 as prognosticators in primarily endocrine-treated prostate cancer.

    Science.gov (United States)

    Tolonen, Teemu T; Tammela, Teuvo L J; Kujala, Paula M; Tuominen, Vilppu J; Isola, Jorma J; Visakorpi, Tapio

    2011-11-01

    • To evaluate the prognostic value of histopathological variables and immunostainings of biomarkers enhancer of zeste homologue 2 (EZH2), Ki-67 and minichromosome maintenance protein 7 (MCM7) from core biopsies of hormonally treated patients with prostate cancer. • Biopsies of 247 primarily endocrine-treated patients were analysed for histopathological characteristics and Gleason scores (GS) according to the revised guidelines of International Society of Urologic Pathology (ISUP) consensus conference 2005. • Immunohistochemical stainings were analysed with the aid of digital image analysis. • The prognostic value of the histopathological variables and the biomarkers was analysed with univariate and multivariate Cox regression analysis, with biochemical recurrence as an endpoint. • Biomarkers EZH2 (relative risk [RR] 2.0, 95% confidence interval 1.2-3.3), Ki-67 (3.4, 2.1-5.5) and MCM7 (2.4, 1.5-3.9) were significantly associated with progression-free survival in a univariate analysis. • Ki-67 immunostaining index detected high-risk patients with GS of 7 (9.1, 8.0-10.3). • In a multivariate analysis with non-conventional GS groups 5-7 (3 + 4), 7(4 + 3)-8, and 9-10, the independent prognostic markers were pretreatment GS (2.2, 1.5-3.2), prostate-specific antigen (PSA) level (2.1, 1.1-4.2), perineural invasion (PNI) (1.6, 1.2-2.2), and clinical T-stage (cT) (1.9, 1.0-3.7). • Combination of the independent markers (PSA level > 20 ng/mL or GS >3 + 4 or PNI >3 or cT >2) yielded best risk stratification (RR 11.6, 10.4-12.7). • GS remains one of the most important prognostic factors in prostate cancer. However, the refined guidelines by ISUP 2005 might have shifted the threshold between low-grade and high-grade cancers from GS 6 vs 7 to GS 3 + 4 vs 4 + 3. • PNI is an independent prognostic marker superior to cT. • Ki-67 is the most useful biomarker in detecting patients with GS = 7 at high risk for progression. © 2011 THE AUTHORS. BJU INTERNATIONAL

  19. 13C-metabolic flux ratio and novel carbon path analyses confirmed that Trichoderma reesei uses primarily the respirative pathway also on the preferred carbon source glucose

    Directory of Open Access Journals (Sweden)

    Saloheimo Markku

    2009-10-01

    and respirative activities of the TCA cycle. Conclusion High similarity between the biosynthetic pathways of amino acids in T. reesei and yeast S. cerevisiae was concluded. In vivo flux distributions confirmed that T. reesei uses primarily the respirative pathway also when growing on the repressive carbon source glucose in contrast to Saccharomyces cerevisiae, which substantially diminishes the respirative pathway flux under glucose repression.

  20. Magnetic resonance hypointensive signal primarily originates from extracellular iron particles in the long-term tracking of mesenchymal stem cells transplanted in the infarcted myocardium

    Directory of Open Access Journals (Sweden)

    Huang Z

    2015-03-01

    deposits were detected by pathological examination. However, iron particles were predominantly distributed in the extracellular space, and a minority was distributed within CD68-positive macrophages and other CD68-negative cells. No sex-determining region Y DNA of donor MSCs was detected.Conclusion: CMR hypointensive signal is primarily caused by extracellular iron particles in the long-term tracking of transplanted MSCs after myocardial infarction. Consideration should be given to both the false-positive signal and the potential cardiac toxicity of long-standing iron deposits in the heart. Keywords: superparamagnetic iron oxide nanoparticles, SPIO, cardiac magnetic resonance (CMR, stem cells tracking, extracellular iron particles, myocardial infarction (MI

  1. PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model

    Directory of Open Access Journals (Sweden)

    Catherine M. Rondelli

    2016-01-01

    Full Text Available 7,12-Dimethylbenz(aanthracene (DMBA rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU, in mouse bone marrow (BM leading to mature cell losses as replenishment fails. These losses are mediated by Cyp1b1, independent of the AhR, despite induction of Cyp1b1. BM mesenchymal progenitor cells (MPC may mediate these responses since basal Cyp1b1 is minimally induced. PreB colony forming unit activity (PreB CFU is lost within 24 hours in isolated BM cells (BMC unless cocultured with cells derived from primary MPC (BMS2 line. The mouse embryonic OP9 line, which provides more efficient coculture support, shares similar induction-resistant Cyp1b1 characteristics. This OP9 support is suppressed by DMBA, which is then prevented by Cyp1b1 inhibitors. OP9-enriched medium partially sustains CFU activities but loses DMBA-mediated suppression, consistent with mediation by OP9 Cyp1b1. PreB CFU activity in BMC from Cyp1b1-ko mice has enhanced sensitivity to DMBA. BMC gene expression profiles identified cytokines and developmental factors that are substantially changed in Cyp1b1-ko mice. DMBA had few effects in WT mice but systematically modified many clustered responses in Cyp1b1-ko mice. Typical BMC AhR-responsive genes were insensitive to Cyp1b1 deletion. TCDD replicated Cyp1b1 interventions, suggesting alternative AhR mediation. Cyp1b1 also diminishes oxidative stress, a key cause of stem cell instability.

  2. Readiness to Change and Reasons for Intended Reduction of Alcohol Consumption in Emergency Department versus Trauma Population

    Directory of Open Access Journals (Sweden)

    Craig Harrison

    2014-05-01

    Full Text Available Introduction: The primary objective was to identify the most common reasons for intending to cut back on alcohol use, in emergency department (ED and trauma patient populations. The secondary objective was to determine the association between reason to cut back on alcohol and education level. Methods: We conducted the study at a level one trauma center in California between 2008 and 2012. This was a retrospective analysis of data collected from computerized alcohol screening and intervention (CASI. We excluded patients who drank too little, and those whose scores were consistent with dependency (Alcohol Use Disorders Identification Test [AUDIT]>19. The CASI database includes the patient’s age, gender, language, education level, an AUDIT score (1-40 scale, a readiness to change score (1-10, and the option to choose any of 10 “reasons to cut back” on their alcohol consumption. Results: From 10,537 patients, 1,202 met criteria for the study (848 ED, 354 trauma. Overall, the most common reasons cited for cutting back on alcohol were “To avoid health problems” (68.5%, “To avoid getting a DUI” (43.6%, “It could save me money” (42.0%, and “To avoid situations where I could get hurt” (41.0%. Trauma patients cited the following reasons significantly more than ED patients: “To avoid situations where I could get hurt” (46.3% versus 38.8%, respectively, “So I can be in control of my behavior” (40.7% versus 32.2%, and “My partner or spouse wants me to stop” (20.1% versus 15.0%. Additionally, those patients who cited “To avoid health problems” reported 1.2 points higher than average (p<0.001 on the 10-point readiness to change scale. Those who have completed some college or an associate degree cited “To avoid health problems” less often than high school graduates (odds ratio [OR] 0.45, while they cited “To avoid situations where I could get hurt” (OR 2.5 and “To avoid being in a car crash caused by alcohol use

  3. Safety evaluation of mechanical recycling processes used to produce polyethylene terephthalate (PET) intended for food contact applications.

    Science.gov (United States)

    Barthélémy, E; Spyropoulos, D; Milana, M-R; Pfaff, K; Gontard, N; Lampi, E; Castle, L

    2014-01-01

    The development of a scheme for the safety evaluation of mechanical recycling processes for polyethylene terephthalate (PET) is described. The starting point is the adoption of a threshold of toxicological concern such that migration from the recycled PET should not give rise to a dietary exposure exceeding 0.0025 μg kg(-1) bw day(-1), the exposure threshold value for chemicals with structural alerts raising concern for potential genotoxicity, below which the risk to human health would be negligible. It is practically impossible to test every batch of incoming recovered PET and every production batch of recycled PET for all the different chemical contaminants that could theoretically arise. Consequently, the principle of the safety evaluation is to measure the cleaning efficiency of a recycling process by using a challenge test with surrogate contaminants. This cleaning efficiency is then applied to reduce a reference contamination level for post-consumer PET, conservatively set at 3 mg kg(-1) PET for a contaminant resulting from possible misuse by consumers. The resulting residual concentration of each contaminant in recycled PET is used in conservative migration models to calculate migration levels, which are then used along with food consumption data to give estimates of potential dietary exposure. The default scenario, when the recycled PET is intended for general use, is that of an infant weighing 5 kg and consuming every day powdered infant formula reconstituted with 0.75 L of water coming from water bottles manufactured with 100% recycled PET. According to this scenario, it can be derived that the highest concentration of a substance in water that would ensure that the dietary exposure of 0.0025 µg kg(-1) bw day(-1) is not exceeded, is 0.017 μg kg(-1) food. The maximum residual content that would comply with this migration limit depends on molecular weight and is in the range 0.09-0.32 mg kg(-1) PET for the typical surrogate contaminants.

  4. United Nations International Drug Control Programme responds

    Directory of Open Access Journals (Sweden)

    Michael Platzer

    2002-01-01

    Full Text Available [First paragraph] We would like to reply to the article written by Axel Klein entitled, "Between the Death Penalty and Decriminalization: New Directions for Drug Control in the Commonwealth Caribbean" published in NWIG 75 (3&4 2001. We have noted a number of factual inaccuracies as well as hostile comments which portray the United Nations International Drug Control Programme in a negative light. This reply is not intended to be a critique of the article, which we find unbalanced and polemical, but rather an alert to the tendentious statements about UNDCP, which we feel should be corrected.

  5. Perspectives on animal welfare legislation and study considerations for field-oriented studies of raptors in the United States

    Science.gov (United States)

    Boal, C.W.; Wallace, M.C.; Strobel, B.

    2010-01-01

    Concern for the welfare of animals used in research and teaching has increased over the last 50 yr. Animal welfare legislation has resulted in guidelines for the use of animals in research, but the guidelines can be problematic because they focus on animals used in laboratory and agriculture research. Raptor biologists can be constrained by guidelines, restrictions, and oversight that were not intended for field research methods or wild animals in the wild or captivity. Field researchers can be further hampered by not understanding animal welfare legislation, who is subject to oversight, or that oversight is often provided by a committee consisting primarily of scientists who work with laboratory animals. Raptor researchers in particular may experience difficulty obtaining approval due to use of various species-specific trapping and handling methods. We provide a brief review of animal welfare legislation and describe the basic components and responsibilities of an Institutional Animal Care and Use Committee (IACUC) in the United States. We identify topics in raptor research that are especially problematic to obtaining IACUC approval, and we provide insight on how to address these issues. Finally, we suggest that all raptor researchers, regardless of legal requirements, abide by the spirit of the animal welfare principles. Failure to do so may bring about further regulatory and permitting restrictions. ?? 2010 The Raptor Research Foundation, Inc.

  6. Design and test of a flywheel energy storage unit for spacecraft application

    Science.gov (United States)

    Cormack, A., III; Notti, J. E., Jr.; Ruiz, M. L.

    1975-01-01

    This paper summarizes the design and test of a development flywheel energy storage device intended for spacecraft application. The flywheel unit is the prototype for the rotating assembly portion of an Integrated Power and Attitude Control System (IPACS). The paper includes a general description of the flywheel unit; specific design characteristics for the rotor and bearings, motor-generators, and electronics; an efficiency analysis; and test results for a research unit.

  7. An exploratory study of treated-bed nets in Timor-Leste: patterns of intended and alternative usage

    Directory of Open Access Journals (Sweden)

    Wilder-Smith Annelies

    2011-07-01

    Full Text Available Abstract Background The Timor-Leste Ministry of Health has recently finalized the National Malaria Control Strategy for 2010-2020. A key component of this roadmap is to provide universal national coverage with long-lasting insecticide-treated nets (LLINs in support of achieving the primary goal of reducing both morbidity and mortality from malaria by 30% in the first three years, followed by a further reduction of 20% by end of the programme cycle in 2020 1. The strategic plan calls for this target to be supported by a comprehensive information, education and communication (IEC programme; however, there is limited prior research into household and personal usage patterns to assist in the creation of targeted, effective, and socio-culturally specific behaviour change materials. Methods Nine separate focus group discussions (FGDs were carried out in Dili, Manatuto, and Covalima districts, Democratic Republic of Timor-Leste, in July 2010. These focus groups primarily explored themes of perceived malaria risk, causes of malaria, net usage patterns within families, barriers to correct and consistent usage, and the daily experience of users (both male and female in households with at least one net. Comprehensive qualitative analysis utilized open source analysis software. Results The primary determinants of net usage were a widespread perception that nets could or should only be used by pregnant women and young children, and the availability of sufficient sleeping space under a limited number of nets within households. Both nuisance biting and disease prevention were commonly cited as primary motivations for usage, while seasonality was not a significant factor. Long-term net durability and ease of hanging were seen as key attributes in net design preference. Very frequent washing cycles were common, potentially degrading net effectiveness. Finally, extensive re-purposing of nets (fishing, protecting crops was both reported and observed, and may

  8. An AC modulated near infrared gain calibration system for a "Violin-Mode" transimpedance amplifier, intended for advanced LIGO suspensions.

    Science.gov (United States)

    Lockerbie, N A; Tokmakov, K V

    2016-07-01

    The background to this work was a prototype shadow sensor, which was designed for retro-fitting to an advanced LIGO (Laser Interferometer Gravitational wave Observatory) test-mass/mirror suspension, in which a 40 kg test-mass/mirror is suspended by four approximately 600 mm long by 0.4 mm diameter fused-silica suspension fibres. The shadow sensor comprised a LED source of Near InfraRed (NIR) radiation, and a "tall-thin" rectangular silicon photodiode detector, which together were to bracket the fibre under test. The photodiode was positioned so as to be sensitive (primarily) to transverse "Violin-Mode" vibrations of such a fibre, via the oscillatory movement of the shadow cast by the fibre, as this moved across the face of the detector. In this prototype shadow sensing system the photodiode was interfaced to a purpose-built transimpedance amplifier, this having both AC and DC outputs. A quasi-static calibration was made of the sensor's DC responsivity, i.e., incremental rate of change of output voltage versus fibre position, by slowly scanning a fused-silica fibre sample transversely through the illuminating beam. The work reported here concerns the determination of the sensor's more important AC (Violin-Mode) responsivity. Recognition of the correspondence between direct AC modulation of the source, and actual Violin-Mode signals, and of the transformative role of the AC/DC gain ratio for the amplifier, at any modulation frequency, f, resulted in the construction of the AC/DC calibration source described here. A method for determining in practice the transimpedance AC/DC gain ratio of the photodiode and amplifier, using this source, is illustrated by a specific numerical example, and the gain ratio for the prototype sensing system is reported over the frequency range 1 Hz-300 kHz. In fact, a maximum DC responsivity of 1.26 kV.m(-1) was measured using the prototype photodiode sensor and amplifier discussed here. Therefore, the measured AC/DC transimpedance gain

  9. Low-Carbon Energy Development in Indonesia in Alignment with Intended Nationally Determined Contribution (INDC by 2030

    Directory of Open Access Journals (Sweden)

    Ucok W.R. Siagian

    2017-01-01

    Full Text Available This study analyzed the role of low-carbon energy technologies in reducing the greenhouse gas emissions of Indonesia’s energy sector by 2030. The aim of this study was to provide insights into the Indonesian government’s approach to developing a strategy and plan for mitigating emissions and achieving Indonesia’s emission reduction targets by 2030, as pledged in the country’s Intended Nationally Determined Contribution. The Asia-Pacific Integrated Model/Computable General Equilibrium (AIM/CGE model was used to quantify three scenarios that had the same socioeconomic assumptions: baseline, countermeasure (CM1, and CM2, which had a higher emission reduction target than that of CM1. Results of the study showed that an Indonesian low-carbon energy system could be achieved with two pillars, namely, energy efficiency measures and deployment of less carbon-intensive energy systems (i.e., the use of renewable energy in the power and transport sectors, and the use of natural gas in the power sector and in transport. Emission reductions would also be satisfied through the electrification of end-user consumption where the electricity supply becomes decarbonized by deploying renewables for power generation. Under CM1, Indonesia could achieve a 15.5% emission reduction target (compared to the baseline scenario. This reduction could be achieved using efficiency measures that reduce final energy demand by 4%; This would require the deployment of geothermal power plants at a rate six times greater than the baseline scenario and four times the use of hydropower than that used in the baseline scenario. Greater carbon reductions (CM2; i.e., a 27% reduction could be achieved with similar measures to CM1 but with more intensive penetration. Final energy demand would need to be cut by 13%, deployment of geothermal power plants would need to be seven times greater than at baseline, and hydropower use would need to be five times greater than the baseline case

  10. Physical Therapy Intervention in the Neonatal Intensive Care Unit

    Science.gov (United States)

    Byrne, Eilish; Garber, June

    2013-01-01

    This article presents the elements of the Intervention section of the Infant Care Path for Physical Therapy in the Neonatal Intensive Care Unit (NICU). The types of physical therapy interventions presented in this path are evidence-based and the suggested timing of these interventions is primarily based on practice knowledge from expert…

  11. The United States Enters the Korean Conflict. Teaching with Documents.

    Science.gov (United States)

    National Archives and Records Administration, Washington, DC.

    After World War II the United States centered its foreign policy on the containment of communism, at home and abroad. Although it was aimed primarily at containing the spread of communism in Europe, the policy also extended to Asia. Asia proved to be the site of the first major battle waged in the name of containment: the Korean War. Dividing…

  12. Antifungal susceptibility of 205 Candida spp. isolated primarily during invasive Candidiasis and comparison of the Vitek 2 system with the CLSI broth microdilution and Etest methods.

    Science.gov (United States)

    Bourgeois, N; Dehandschoewercker, L; Bertout, S; Bousquet, P-J; Rispail, P; Lachaud, L

    2010-01-01

    Infections due to Candida spp. are frequent, particularly in immunocompromised and intensive care unit patients. Antifungal susceptibility tests are now required to optimize antifungal treatment given the emergence of acquired antifungal resistance in some Candida species. An antifungal susceptibility automated method, the Vitek 2 system (VK2), was evaluated. VK2 was compared to the CLSI broth microdilution reference method and the Etest procedure. For this purpose, 205 clinical isolates of Candida spp., including 11 different species, were tested for fluconazole, voriconazole, and amphotericin B susceptibility. For azoles, essential agreement ranged from 25% to 100%, depending on the method used and the Candida species tested. Categorical agreements for all of the species averaged 92.2% and ranged from 14.3 to 100%, depending on the 24-h or 48-h MIC reading by the Etest and CLSI methods and on the Candida species. Results obtained for Candida albicans showed excellent categorical and essential agreements with the two comparative methods. For Candida glabrata, the essential agreement was high with the CLSI method but low with the Etest method, and several very major errors in interpretation were observed between VK2 and the Etest method for both azoles. Low MICs of fluconazole were obtained for all of the Candida krusei isolates, but the VK2 expert software corrected all of the results obtained to resistant. Amphotericin B results showed MICs of CLSI), and 202 (Etest) isolates. The AST-YS01 Vitek 2 card system (bioMérieux) is a reliable and practical standardized automated antifungal susceptibility test. Nevertheless, more assays are needed to better evaluate C. glabrata fluconazole sensitivity.

  13. Antifungal Susceptibility of 205 Candida spp. Isolated Primarily during Invasive Candidiasis and Comparison of the Vitek 2 System with the CLSI Broth Microdilution and Etest Methods▿

    Science.gov (United States)

    Bourgeois, N.; Dehandschoewercker, L.; Bertout, S.; Bousquet, P.-J.; Rispail, P.; Lachaud, L.

    2010-01-01

    Infections due to Candida spp. are frequent, particularly in immunocompromised and intensive care unit patients. Antifungal susceptibility tests are now required to optimize antifungal treatment given the emergence of acquired antifungal resistance in some Candida species. An antifungal susceptibility automated method, the Vitek 2 system (VK2), was evaluated. VK2 was compared to the CLSI broth microdilution reference method and the Etest procedure. For this purpose, 205 clinical isolates of Candida spp., including 11 different species, were tested for fluconazole, voriconazole, and amphotericin B susceptibility. For azoles, essential agreement ranged from 25% to 100%, depending on the method used and the Candida species tested. Categorical agreements for all of the species averaged 92.2% and ranged from 14.3 to 100%, depending on the 24-h or 48-h MIC reading by the Etest and CLSI methods and on the Candida species. Results obtained for Candida albicans showed excellent categorical and essential agreements with the two comparative methods. For Candida glabrata, the essential agreement was high with the CLSI method but low with the Etest method, and several very major errors in interpretation were observed between VK2 and the Etest method for both azoles. Low MICs of fluconazole were obtained for all of the Candida krusei isolates, but the VK2 expert software corrected all of the results obtained to resistant. Amphotericin B results showed MICs of ≤1 mg/liter for 201 (VK2), 190 (CLSI), and 202 (Etest) isolates. The AST-YS01 Vitek 2 card system (bioMérieux) is a reliable and practical standardized automated antifungal susceptibility test. Nevertheless, more assays are needed to better evaluate C. glabrata fluconazole sensitivity. PMID:19889902

  14. Building Footprints, Primarily residential, at risk buildings such as hospitals, nursing homes, etc for use in Emergency Management Hazard Mitigation planning., Published in 2010, 1:4800 (1in=400ft) scale, Carroll County Government.

    Data.gov (United States)

    NSGIC Local Govt | GIS Inventory — Building Footprints dataset current as of 2010. Primarily residential, at risk buildings such as hospitals, nursing homes, etc for use in Emergency Management Hazard...

  15. 41 CFR 105-68.330 - What requirements must I pass down to persons at lower tiers with whom I intend to do business?

    Science.gov (United States)

    2010-07-01

    ... pass down to persons at lower tiers with whom I intend to do business? 105-68.330 Section 105-68.330... DEBARMENT AND SUSPENSION (NONPROCUREMENT) Responsibilities of Participants Regarding Transactions Doing Business with Other Persons § 105-68.330 What requirements must I pass down to persons at lower tiers...

  16. 21 CFR 510.106 - Labeling of antibiotic and antibiotic-containing drugs intended for use in milk-producing animals.

    Science.gov (United States)

    2010-04-01

    ... ANIMAL DRUGS Specific Administrative Rulings and Decisions § 510.106 Labeling of antibiotic and antibiotic-containing drugs intended for use in milk-producing animals. Whenever the labeling of an... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Labeling of antibiotic and...

  17. 10 CFR Appendix G to Part 20 - Requirements for Transfers of Low-Level Radioactive Waste Intended for Disposal at Licensed Land...

    Science.gov (United States)

    2010-01-01

    ... Intended for Disposal at Licensed Land Disposal Facilities and Manifests G Appendix G to Part 20 Energy NUCLEAR REGULATORY COMMISSION STANDARDS FOR PROTECTION AGAINST RADIATION Pt. 20, App. G Appendix G to Part... 1985 (e.g., waste generated as a result of decontamination or recycle activities). High...

  18. Buen Viaje: Mutually Beneficial Tourism. A Four-Lesson Unit about Traveling with Care in Mexico for Grades 8-12 and Adult Learners in English and Spanish.

    Science.gov (United States)

    Mattson, Alexandra; Ruiz, Octavio; Sommers, Meredith

    Intended for secondary students, this curriculum unit (in both English and Spanish) provides a look into Mexico's second largest industry, tourism. The curriculum unit of four lessons includes general information about tourism, maps, stories, and a code of behavior for travelers. The unit enumerates learner objectives, defines vocabulary and…

  19. 孕产妇计划妊娠影响因素分析%Analysis of influencing factors of intended pregnancy

    Institute of Scientific and Technical Information of China (English)

    李成福; 宋新明

    2012-01-01

    Objective: To explore the prevalence of intended pregnancy and its influencing factors among maternal women. Methods: Data used in this paper were from a retrospective survey of maternal women between 2002 and 2004, which was conducted by face - to - face study in Wuxi. The total number of women was 1 628. A logistic regression model was used to analyze the influencing factors of intended pregnancy. Results; The proportion of intended pregnancy was 73. 2% in this study. Regression analysis showed that the maternal women with childbearing age over 30, same education level as husbands, small number of family size, per capital household income for upper stage, accessing other health insurance in addition to basic medical insurance, and having been to health counseling agencies, folic acid supplement, TORCH and/or chromosome examinations before pregnancy had much higher proportion of intended pregnancy. Conclusion: Many factors impact on intended pregnancy. To increase the proportion of intended pregnancies, the comprehensive intervention model, in which government, communities , families, and individuals jointly participate, should be established to peomote intended pregnancy.%目的:探讨影响计划妊娠的相关因素.方法:利用无锡市2002~2004年孕产妇回顾性调查资料,采用入户面对面调查方式,运用logistic回归分析进行影响因素分析.结果:共调查1 628例孕产妇,计划妊娠比例为73.2%.多因素分析结果显示,生育年龄≥30岁、与丈夫文化程度相同、孕前家庭人口数少、人均家庭收入较高,以及除享有基本医疗保险以外还享有其他医疗保险的孕产妇计划妊娠的比例高;孕前去过咨询机构、孕前补充过叶酸和孕前进行TORCH或染色体检查的孕产妇计划妊娠的比例高.结论:计划妊娠受到多种因素影响,为提高计划妊娠比例,应建立政府、社区、家庭、个人共同参与的综合干预模式.

  20. Are freestanding midwifery units a safe alternative to obstetric units for low-risk, primiparous childbirth?

    DEFF Research Database (Denmark)

    Christensen, Louise Fischer; Overgaard, Charlotte

    2017-01-01

    BACKGROUND: Intrapartum complications and the use of obstetric interventions are more common in primiparous childbirth than in multiparous childbirth, leading to concern about out of hospital birth for primiparous women. The purpose of this study was to determine whether the effect of birthplace...... ratios and effect ratios with 95% confidence intervals for matched pairs stratified by parity. RESULTS: On no outcome did the effect of birthplace differ significantly between primiparous and multiparous women. Compared with their counterparts intending birth in an obstetric unit, both primiparous...... for multiparas remained stable. CONCLUSIONS: Freestanding midwifery units appear to confer significant advantages over obstetric units to both primiparous and multiparous mothers, while their infants are equally safe in both settings. Our findings thus support the provision of care in freestanding midwifery...

  1. Reasons for cancellation of operation on the day of intended surgery in a multidisciplinary 500 bedded hospital

    Directory of Open Access Journals (Sweden)

    Rajender Kumar

    2012-01-01

    Full Text Available Background: Cancellation of operations in hospitals is a significant problem with far reaching consequences. This study was planned to evaluate reasons for cancellation of elective surgical operation on the day of surgery in a 500 bedded Government hospital. Materials and Methods: The medical records of all the patients, from December 2009 to November 2010, who had their operations cancelled on the day of surgery in all surgical units of the hospital, were audited prospectively. The number of operation cancelled and reasons for cancellation were documented. Results: 7272 patients were scheduled for elective surgical procedures during study period; 1286 (17.6 % of these were cancelled on the day of surgery. The highest number of cancellation occurred in the discipline of general surgery (7.1% and the least (0.35% occurred in Ear-Nose-Throat surgery. The most common cause of cancellation was the lack of availability of theater time 809 (63% and patients not turning up 244 (19% patients. 149 cancellations (11.6% were because of medical reasons; 16 (1.2% were cancelled by the surgeon due to a change in the surgical plan; 28 (2.1% were cancelled as patients were not ready for surgery; and 40 (3.1% were cancelled due to equipment failure.]. Conclusion: Most causes of cancellations of operations are preventable.

  2. Large-scale, long-term silvicultural experiments in the United States: historical overview and contemporary examples.

    Science.gov (United States)

    R. S. Seymour; J. Guldin; D. Marshall; B. Palik

    2006-01-01

    This paper provides a synopsis of large-scale, long-term silviculture experiments in the United States. Large-scale in a silvicultural context means that experimental treatment units encompass entire stands (5 to 30 ha); long-term means that results are intended to be monitored over many cutting cycles or an entire rotation, typically for many decades. Such studies...

  3. Understanding the Nature of Small Business. PACE Revised. Level 3. Unit 1. Research & Development Series No. 240CB1.

    Science.gov (United States)

    Ashmore, M. Catherine; Pritz, Sandra G.

    This individualized, competency-based unit on understanding the nature of small business, the first of 18 modules, is on the third level of the revised Program for Acquiring Competence in Entrepreneurship (PACE). Intended for the advanced secondary and postsecondary levels and for adults wanting training or retraining, this unit, together with the…

  4. Experimental verification of a CFD model intended for the determination of restitution coefficients used in erosion modelling

    Directory of Open Access Journals (Sweden)

    Hernik Bartłomiej

    2017-01-01

    Full Text Available Erosion caused by solid particles transported with the steam or flue gas has a negative impact on the power unit reliability and availability. The erosion rate depends inter alia on the restitution of the particle velocity upon impact. The restitution coefficients determine the angle of the particle reflection off the tube surface and the particle post-impingement velocity, i.e., they determine the direction of the particle path, which has a substantial impact on the erosion phenomenon inside the tube. An attempt is made herein to develop a method of determination of restitution coefficients by means of numerical modelling assisted by experimental testing on physical models that will be implemented further in the Ansys Fluent code. Such a numerical procedure will verify the model of erosion caused by particles of iron oxides. The erodent impingement angle α1, the impingement velocity w1, and the reflection velocity w2 are measured using the Casio High-Speed Exilim EX-F1 camera, which enables filming at a high rate. The film is then processed graphically for “frame-by-frame” tracking. The following erodents were used in the testing: iron oxides, quartz sand with a different grain size (490, 1000, 1500, 2000 μm, and 1000 μm-diameter steel balls. The steel balls, due to their ideal shape, were treated as the comparative analysis reference standard. Erosion of three types of 5x10 cm plates was tested: a plasma-coated plate with an anti-erosion layer, an aluminium plate; and a steel sheet plate. Based on the restitution coefficient testing results, numerical simulations were performed of the particle reflection off the surface.

  5. Environmental Securitization within the United Nations: A Political Ecology Perspective

    OpenAIRE

    2013-01-01

    If empirical evidences show that environmental security is on the United Nations agenda, very few studies try to understand the agenda-setting process of this issue. My thesis research intends to fill this gap by analyzing the process of environmental securitization within the organization. Securitization theories and critical security studies propose a first useful set of theoretical tools. Nonetheless, this communication argues that they are not the only ones, and that Political Ecology cou...

  6. Quarterly report -- Physics unit: October--December, 1953

    Energy Technology Data Exchange (ETDEWEB)

    Davenport, D.E.; Faulkner, J.E.; Ozeroff, J.

    1954-01-11

    This report is intended to be a description of current work being done by the Physics Unit at the Hanford Atomic Products Operation. The work is concerned mainly with the study of graphite-moderated natural uranium reactors for the production of plutonium on a large scale. In addition, varied physics problems associated with the operation of an industrial atomic plant are occasionally dealt with. The report is divided into four sections; lattice physics; nuclear physics; irradiation physics; and plant physics.

  7. USGS Small-scale Dataset - 1:1,000,000-Scale Streams of the United States 201403 Shapefile

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map layer shows streams of the United States, Puerto Rico, and the U.S. Virgin Islands. The map layer was produced primarily from the Medium-Resolution and...

  8. USGS Small-scale Dataset - 1:1,000,000-Scale Waterbodies and Wetlands of the United States 201403 Shapefile

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map layer contains waterbodies and wetlands of the United States, Puerto Rico, and the U.S. Virgin Islands. The map layer was produced primarily from the...

  9. Vesicular stomatitis outbreak in the southwestern United States, 2012.

    Science.gov (United States)

    McCluskey, Brian J; Pelzel-McCluskey, Angela M; Creekmore, Lynn; Schiltz, John

    2013-09-01

    Vesicular stomatitis is a viral disease primarily affecting horses and cattle when it occurs in the United States. Outbreaks in the southwestern United States occur sporadically, with initial cases typically occurring in Texas, New Mexico, or Arizona and subsequent cases occurring in a northward progression. The viruses causing vesicular stomatitis can be transmitted by direct contact of lesioned animals with other susceptible animals, but transmission is primarily through arthropod vectors. In 2012, an outbreak of vesicular stomatitis in the United States occurred that was caused by Vesicular stomatitis New Jersey virus serotype. Overall, 51 horses on 36 premises in 2 states were confirmed positive. Phylogenetic analysis of the virus indicated that it was most closely related to viruses detected in the state of Veracruz, Mexico, in 2000.

  10. Mobile-based intervention intended to stop obesity in preschool-aged children: the MINISTOP randomized controlled trial.

    Science.gov (United States)

    Nyström, Christine Delisle; Sandin, Sven; Henriksson, Pontus; Henriksson, Hanna; Trolle-Lagerros, Ylva; Larsson, Christel; Maddison, Ralph; Ortega, Francisco B; Pomeroy, Jeremy; Ruiz, Jonatan R; Silfvernagel, Kristin; Timpka, Toomas; Löf, Marie

    2017-06-01

    Background: Traditional obesity prevention programs are time- and cost-intensive. Mobile phone technology has been successful in changing behaviors and managing weight; however, to our knowledge, its potential in young children has yet to be examined.Objective: We assessed the effectiveness of a mobile health (mHealth) obesity prevention program on body fat, dietary habits, and physical activity in healthy Swedish children aged 4.5 y.Design: From 2014 to 2015, 315 children were randomly assigned to an intervention or control group. Parents in the intervention group received a 6-mo mHealth program. The primary outcome was fat mass index (FMI), whereas the secondary outcomes were intakes of fruits, vegetables, candy, and sweetened beverages and time spent sedentary and in moderate-to-vigorous physical activity. Composite scores for the primary and secondary outcomes were computed.Results: No statistically significant intervention effect was observed for FMI between the intervention and control group (mean ± SD: -0.23 ± 0.56 compared with -0.20 ± 0.49 kg/m(2)). However, the intervention group increased their mean composite score from baseline to follow-up, whereas the control group did not (+0.36 ± 1.47 compared with -0.06 ± 1.33 units; P = 0.021). This improvement was more pronounced among the children with an FMI above the median (4.11 kg/m(2)) (P = 0.019). The odds of increasing the composite score for the 6 dietary and physical activity behaviors were 99% higher for the intervention group than the control group (P = 0.008).Conclusions: This mHealth obesity prevention study in preschool-aged children found no difference between the intervention and control group for FMI. However, the intervention group showed a considerably higher postintervention composite score (a secondary outcome) than the control group, especially in children with a higher FMI. Further studies targeting specific obesity classes within preschool-aged children are warranted. This trial was

  11. Short rotation woody crops: Using agroforestry technology for energy in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Wright, L L; Ranney, J W

    1991-01-01

    Agroforestry in the United States is being primarily defined as the process of using trees in agricultural systems for conservation purposes and multiple products. The type of agroforestry most commonly practiced in many parts of the world, that is the planting of tree crops in combination with food crops or pasture, is the type least commonly practiced in the United States. One type of agroforestry technique, which is beginning now and anticipated to expand to several million acres in the United States, is the planting of short-rotation woody crops (SRWCs) primarily to provide fiber and fuel. Research on SRWC's and environmental concerns are described.

  12. Comparative Study of Effective Factors on Students’ Interests in Fashion at Islamic Azad University Arak Unit and South Tehran Unit Academic Year 2010-2011

    OpenAIRE

    Tahmineh Zareei

    2013-01-01

    This paper intends to provide a comparative study of effective factors on students’ interests in fashion at Faculty of Human Sciences – Islamic Azad University – Arak unit and also Islamic Azad University- South Tehran Unit through academic year 2010- 2011. According to the findings, it is obvious that fashion and any interests in fashion changed into a great social problem among university students. This paper used any thoughts of different specialists including Siemel and Veblen as the high...

  13. Workshop Physics Activity Guide, Module 2: Mechanics II, Momentum, Energy, Rotational and Harmonic Motion, and Chaos (Units 8 - 15)

    Science.gov (United States)

    Laws, Priscilla W.

    2004-05-01

    The Workshop Physics Activity Guide is a set of student workbooks designed to serve as the foundation for a two-semester calculus-based introductory physics course. It consists of 28 units that interweave text materials with activities that include prediction, qualitative observation, explanation, equation derivation, mathematical modeling, quantitative experiments, and problem solving. Students use a powerful set of computer tools to record, display, and analyze data, as well as to develop mathematical models of physical phenomena. The design of many of the activities is based on the outcomes of physics education research. The Workshop Physics Activity Guide is supported by an Instructor's Website that: (1) describes the history and philosophy of the Workshop Physics Project; (2) provides advice on how to integrate the Guide into a variety of educational settings; (3) provides information on computer tools (hardware and software) and apparatus; and (4) includes suggested homework assignments for each unit. Log on to the Workshop Physics Project website at http://physics.dickinson.edu/ Workshop Physics is a component of the Physics Suite--a collection of materials created by a group of educational reformers known as the Activity Based Physics Group. The Physics Suite contains a broad array of curricular materials that are based on physics education research, including: Understanding Physics, by Cummings, Laws, Redish and Cooney (an introductory textbook based on the best-selling text by Halliday/Resnick/Walker) RealTime Physics Laboratory Modules Physics by Inquiry (intended for use in a workshop setting) Interactive Lecture Demonstration Tutorials in Introductory Physics Activity Based Tutorials (designed primarily for use in recitations)

  14. Pathways of fish invasions in the Mid-Atlantic region of the United States

    Science.gov (United States)

    Lapointe, Nicolas W. R.; Fuller, Pam; Neilson, Matthew; Murphy, Brian R.; Angermeier, Paul

    2016-01-01

    Non-native fish introductions are a major threat to biodiversity and fisheries, and occur through numerous pathways that vary regionally in importance. A key strategy for managing invasions is to focus prevention efforts on pathways posing the greatest risk of future introductions. We identified high-risk pathways for fish establishment in the Mid-Atlantic region of the United States based on estimates of probability of establishment and records of previous introductions, which were considered in the context of emerging socioeconomic trends. We used estimates of propagule pressure, species’ environmental tolerance, and size of species pool to assess the risk of establishment by pathway. Pathways varied considerably in historic importance and species composition, with the majority of species introduced intentionally via stocking (primarily for sport, forage, or biocontrol) or bait release. Bait release, private stocking, illegal introductions intended to establish reproducing populations (e.g., of sport fish), aquaculture, and the sale of live organisms all create risks for future invasions in the Mid-Atlantic region. Of these pathways, bait release probably poses the greatest risk of introductions for the Mid-Atlantic region because propagule pressure is moderate, most released species are tolerant of local environmental conditions, and the pool of species available for transplantation is large. Our findings differ considerably from studies in other regions (e.g., bait release is a dominant pathway in the Mid-Atlantic region, whereas illegal introduction of sport fish is dominant in the western US and aquarium releases are dominant in Florida), demonstrating the need for regional-scale assessments of, and management strategies for, introduction pathways.

  15. Selection of Reference Genes for RT-qPCR Analysis in Coccinella septempunctata to Assess Un-intended Effects of RNAi Transgenic Plants

    OpenAIRE

    Chunxiao Yang; Evan L Preisser; Hongjun Zhang; Yong Liu; Liangying Dai; Huipeng Pan; Xuguo Zhou

    2016-01-01

    The development of genetically engineered plants that employ RNA interference (RNAi) to suppress invertebrate pests opens up new avenues for insect control. While this biotechnology shows tremendous promise, the potential for both non-target and off-target impacts, which likely manifest via altered mRNA expression in the exposed organisms, remains a major concern. One powerful tool for the analysis of these un-intended effects is reverse transcriptase-quantitative polymerase chain reaction, a...

  16. Using SI Units in Astronomy

    Science.gov (United States)

    Dodd, Richard

    2011-12-01

    1. Introduction; 2. An introduction to SI units; 3. Dimensional analysis; 4. Unit of angular measure (radian); 5. Unit of time (second); 6. Unit of length (metre); 7. Unit of mass (kilogram); 8. Unit of luminous intensity (candela); 9. Unit of thermodynamic temperature (kelvin); 10. Unit of electric current (ampere); 11. Unit of amount of substance (mole); 12. Astronomical taxonomy; Index.

  17. Music listening preferences and preadmission dysfunctional psychosocial behaviors of adolescents hospitalized on an in-patient psychiatric unit.

    Science.gov (United States)

    Weidinger, C K; Demi, A S

    1991-01-01

    This study investigated the relationship between music listening preferences and preadmission, dysfunctional psychosocial behaviors (PDPB) of 60 adolescents who were hospitalized on an in-patient psychiatric unit. Findings were that hospitalized adolescents who primarily listened to music with negative lyrics/themes had a history of more PDPB than hospitalized adolescents who primarily listened to music that did not contain negative lyrics/themes; and hospitalized adolescents who primarily listened to heavy metal music had a history of more PDPB than hospitalized adolescents who primarily listened to other types of music.

  18. Impact of (18)F-Fluoride PET on Intended Management of Patients with Cancers Other Than Prostate Cancer: Results from the National Oncologic PET Registry.

    Science.gov (United States)

    Hillner, Bruce E; Siegel, Barry A; Hanna, Lucy; Duan, Fenghai; Shields, Anthony F; Quinn, Bruce; Coleman, R Edward

    2014-07-01

    The National Oncologic PET Registry prospectively assessed the impact of PET with (18)F-sodium fluoride (NaF PET) on intended management of Medicare patients with suspected or known osseous metastasis. We report our findings for cancers other than prostate and make selected comparisons to our previously reported prostate cancer cohort. Data were collected from both referring and interpreting physicians before and after NaF PET in patients (age ≥ 65 y) stratified for initial staging (IS; n = 570), for suspected first osseous metastasis (FOM; n = 1,814; breast, 781 [43%]; lung, 380 [21%]; and all other cancers, 653 [36%]), and for suspected progression of osseous metastasis (POM; n = 435). The dominant indication was bone pain. If NaF PET were unavailable, conventional bone scintigraphy would have been ordered in 85% of patients. In IS, 28% of patients had suspected or confirmed nonosseous metastasis. If neither conventional bone scintigraphy nor NaF PET were available, referring physicians would have ordered other advanced imaging more than 70% of the time rather than initiate treatment for suspected FOM (11%-16%) or POM (18%-22%). When intended management was classified as either treatment or nontreatment, the intended management change for each cancer type was highest in POM, lower in IS, and lowest in FOM. For suspected FOM, intended management change was lower in breast (24%), lung (36%), or other cancers (31%), compared with prostate cancer (44%) (P types. After normal/benign/equivocal PET results, 15% of breast, 30% lung, and 38% prostate cancer patients had treatment, likely reflecting differences in management of nonosseous disease. For patients with definite metastasis on NaF PET, nonprostate, compared with prostate, cancer patients had post-PET plans for more frequent biopsy, alternative imaging, chemotherapy, and radiotherapy. In the smaller IS and POM cohorts, differences among cancer types were not significant. Overall, NaF PET led to change in

  19. Are freestanding midwifery units a safe alternative to obstetric units for low-risk, primiparous childbirth? An analysis of effect differences by parity in a matched cohort study.

    Science.gov (United States)

    Christensen, Louise Fischer; Overgaard, Charlotte

    2017-01-09

    Intrapartum complications and the use of obstetric interventions are more common in primiparous childbirth than in multiparous childbirth, leading to concern about out of hospital birth for primiparous women. The purpose of this study was to determine whether the effect of birthplace on perinatal and maternal morbidity and the use of obstetric interventions differed by parity among low-risk women intending to give birth in a freestanding midwifery unit or in an obstetric unit in the North Denmark Region. The study is a secondary analysis of data from a matched cohort study including 839 low-risk women intending birth in a freestanding midwifery unit (primary participants) and 839 low-risk women intending birth in an obstetric unit (individually matched control group). Analysis was by intention-to-treat. Conditional logistic regression analysis was applied to compute odds ratios and effect ratios with 95% confidence intervals for matched pairs stratified by parity. On no outcome did the effect of birthplace differ significantly between primiparous and multiparous women. Compared with their counterparts intending birth in an obstetric unit, both primiparous and multiparous women intending birth in a freestanding midwifery unit were significantly more likely to have an uncomplicated, spontaneous birth with good outcomes for mother and infant and less likely to require caesarean section, instrumental delivery, augmented labour or epidural analgesia (although for caesarean section this trend did not attain statistical significance for multiparous women). Perinatal outcomes were comparable between the two birth settings irrespective of parity. Compared to multiparas, transfer rates were substantially higher for primiparas, but fell over time while rates for multiparas remained stable. Freestanding midwifery units appear to confer significant advantages over obstetric units to both primiparous and multiparous mothers, while their infants are equally safe in both settings

  20. [Brodie abscess. Primarily misinterpreted as traumatic lesion].

    Science.gov (United States)

    Nicolajsen, K; Jørgensen, P S; Tørholm, C

    1996-01-01

    Two case histories are presented. In the first, a 49 year-old man fell on his right hip. He was able to walk, but because of pain he came to our emergency room. Radiographics gave an impression of an undislocated intertrochanteric fracture, scintigraphy confirmed the suspicion. There were no signs of infection. On starting osteosynthesis with the drilling of a hole in the lateral cortex, discharge of pus was observed and curettage of the abscess cavity was performed. In the second, a 21 year-old man hit his right knee against a table. Because of pain he was admitted to hospital. Primary signs of a lesion of the lateral meniscus were found and arthroscopy was scheduled. When readmitted we found signs of an infection and X-ray revealed a Brodie's abscess in the proximal tibia. The abscess cavity was opened and curettage was performed. Radiographics, scintigraphics, blood parameters and pathological and microbiological investigations revealed primary chronic osteomyelitis in both patients. Antibiotic therapy was instituted and six weeks after primary operation bone transplantation was performed. The further course was uncomplicated.

  1. Human Language, Unit II: Language Curriculum, Level C [Grade Three]; Teacher's Guide.

    Science.gov (United States)

    Oregon Univ., Eugene. Oregon Elementary English Project.

    Developed by the Oregon Elementary English Project, the lessons in this second of a two-part unit on the human language intended for grades three and four revolve around the character Sad Sam, who gets lost in the woods and happens to observe four animals (bears, raccoons, geese, and robins). Having been introduced to Sad Sam in lesson 1, the…

  2. Orchard Business Management. Unit I. Establishing an Orchard Record Keeping System.

    Science.gov (United States)

    Mullinix, Shauna K.

    This guide is intended for use in providing in-depth formal classroom and on-site instruction in the principles of business and financial management as they apply to operating and managing orchards. Designed to be used with an accompanying Orchard Business Management Record Book, this unit (i.e., the first year) of the course deals with…

  3. Orchard Business Management. Unit II. Management and Analysis of the Orchard Operation.

    Science.gov (United States)

    Mullinix, Shauna K.

    This guide is intended for use in providing in-depth formal classroom and on-site instruction in the principles of business and financial management as they apply to operating and managing orchards. Designed to be used with an accompanying Orchard Business Management Record Book, this unit is devoted to management and analysis of an orchard…

  4. Aulice to Build 1,200,000 Units/Y All- steel Tires Project

    Institute of Scientific and Technical Information of China (English)

    Li Zao

    2012-01-01

    To adapt to the rapid development of automobile industry and to meet the market demand on high- performance tires, upon investigation, Hubei Aulice Tire Co., Ltd. intends to build all-steel radial tire production project with the output of 1,200,000 units per year.

  5. Teachers Environmental Resource Unit: Industry: Iron/Steel & Pulp/Paper.

    Science.gov (United States)

    Bemiss, Clair W.

    Iron and steel and pulp and paper industries, two representatives of American industry, are selected in this teacher's guide for the study of industrial pollution and current pollution control efforts. The resource unit is intended to provide the teacher with basic information that will aid classroom review of these problems. Both industries are…

  6. Logic: A Unit for 4-8 Graders, Especially Gifted and Talented.

    Science.gov (United States)

    Runkle, Susan; Tansey, Pam

    The unit on logic is intended to teach critical thinking for gifted and talented students in grades 4-8. Sections are presented separately for students in grades 4-5 and 6-8. The younger students are instructed in such areas as scientific logic, math logic, spatial reasoning, deductive logic, inductive logic, and reasoning with analogies. The…

  7. Cuentos Hispanos de los Estados Unidos (Hispanic Stories of the United States).

    Science.gov (United States)

    Olivares, Julian, Ed.

    This anthology of 21 short stories is intended for Spanish-speaking students of Spanish, other students in intermediate and advanced Spanish-language courses, and students commencing study of the Hispanic literature of the United States. Twelve of the 15 authors are, by birth or descent, of Mexican, Cuban, or Puerto Rican origin. Eight were born…

  8. Orchard Business Management. Unit I. Establishing an Orchard Record Keeping System.

    Science.gov (United States)

    Mullinix, Shauna K.

    This guide is intended for use in providing in-depth formal classroom and on-site instruction in the principles of business and financial management as they apply to operating and managing orchards. Designed to be used with an accompanying Orchard Business Management Record Book, this unit (i.e., the first year) of the course deals with…

  9. Orchard Business Management. Unit II. Management and Analysis of the Orchard Operation.

    Science.gov (United States)

    Mullinix, Shauna K.

    This guide is intended for use in providing in-depth formal classroom and on-site instruction in the principles of business and financial management as they apply to operating and managing orchards. Designed to be used with an accompanying Orchard Business Management Record Book, this unit is devoted to management and analysis of an orchard…

  10. Food and Nutrition. Volume II. Units VI-VIII: Fruit, Fats, Vegetables, Legumes, Grains, Meats.

    Science.gov (United States)

    Honse, Elizabeth Linsenbardt

    These instructional materials are intended as a guide for the instructor of a secondary home economics course in food and nutrition. Topics covered in the three units are time, energy, and resource management; selection, care, preparation, and storage of food (seven lessons on dairy foods; fats and oils; cereals and breads; fruits and vegetables;…

  11. Cuentos Hispanos de los Estados Unidos (Hispanic Stories of the United States).

    Science.gov (United States)

    Olivares, Julian, Ed.

    This anthology of 21 short stories is intended for Spanish-speaking students of Spanish, other students in intermediate and advanced Spanish-language courses, and students commencing study of the Hispanic literature of the United States. Twelve of the 15 authors are, by birth or descent, of Mexican, Cuban, or Puerto Rican origin. Eight were born…

  12. Eligibility Characteristics of Infants and Toddlers Entering Early Intervention Services in the United States

    Science.gov (United States)

    Scarborough, Anita A.; Hebbeler, Kathleen M.; Spiker, Donna

    2006-01-01

    In the United States, legislation originally enacted in 1986 provided grants to states to build interagency service systems for children from birth to 3 years of age with developmental delays and disabilities. This legislation now renamed the Individuals with Disabilities Education Act (IDEA) was intended to facilitate the development of a…

  13. 78 FR 10556 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Trip Limit...

    Science.gov (United States)

    2013-02-14

    ... Northeastern United States; Northeast Multispecies Fishery; Trip Limit Adjustments for the Common Pool Fishery... fishing year. This rule also decreases the trip limits for white hake and pollock. This is intended to...) established the current trip limits for the common pool vessels fishing under a Category A day-at-sea (DAS...

  14. Theoretical study and design of a low-grade heat-driven pilot ejector refrigeration machine operating with butane and isobutane and intended for cooling of gas transported in a gas-main pipeline

    KAUST Repository

    Petrenko, V.O.

    2011-11-01

    This paper describes the construction and performance of a novel combined system intended for natural gas transportation and power production, and for cooling of gas transported in a gas-main pipeline. The proposed system includes a gas turbine compressor, a combined electrogenerating plant and an ejector refrigeration unit operating with a hydrocarbon refrigerant. The combined electrogenerating plant consists of a high-temperature steam-power cycle and a low-temperature hydrocarbon vapor power cycle, which together comprise a binary vapor system. The combined system is designed for the highest possible effectiveness of power generation and could find wide application in gas-transmission systems of gas-main pipelines. Application of the proposed system would enable year-round power generation and provide cooling of natural gas during periods of high ambient temperature operation. This paper presents the main results of a theoretical study and design performance specifications of a low-grade heat-driven pilot ejector refrigeration machine operating with butane and isobutane. © 2010 Elsevier Ltd and IIR. All rights reserved.

  15. Software for simulation of utilization schemes of secondary energy from the exhaust gases of metallurgical units

    Science.gov (United States)

    Olennikov, A. A.; Tsymbal, V. P.

    2016-09-01

    The work is devoted to the program complex intended for designing schemes of secondary energy utilization from metallurgical units. The structure of the software system is based on three levels of complex systems assembled from subsystems. The mathematical models of a complex process of heat transfer and gas dynamics occurring in the energy utilization units and gas cleaning devices. We describe the user interaction with the software package, and show the calculation results in the form of plots.

  16. An Overview of Research Infrastructure for Medieval Studies in the United States: Associations, Institutes, and Universities

    Directory of Open Access Journals (Sweden)

    Zan Kocher

    2011-11-01

    Full Text Available This overview of research infrastructure in the United States brieflymentions some institutes, universities, associations, conferences,sources of funding, types of courses, research databases, academicjournals and book publishers. It intends to make American medievalistresources better accessible to colleagues from other countries, and toencourage those who wish to study in the United States and those whoare using the Internet to seek printed or digital materials for theirteaching or research.

  17. Malaria Treatment (United States)

    Science.gov (United States)

    ... a CDC Malaria Branch clinician. malaria@cdc.gov Malaria Treatment (United States) Recommend on Facebook Tweet Share Compartir Treatment of Malaria: Guidelines For Clinicians (United States) Download PDF version ...

  18. United Cerebral Palsy

    Science.gov (United States)

    ... be sure to follow us on Twitter . United Cerebral Palsy UCP educates, advocates and provides support services to ... Partners Merz Logo Sprint Relay Copyright © 2015 United Cerebral Palsy 1825 K Street NW Suite 600 Washington, DC ...

  19. Unit Cost Compendium Calculations

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Unit Cost Compendium (UCC) Calculations raw data set was designed to provide for greater accuracy and consistency in the use of unit costs across the USEPA...

  20. Establishing the Intermediate Unit.

    Science.gov (United States)

    Pennsylvania State Dept. of Education, Harrisburg.

    The State of Pennsylvania Act 102 establishes a system of 29 intermediate units, creates intermediate unit boards of directors, spells out their duties and functions, and provides a system of financing their operations. This handbook has been prepared by the Pennsylvania Department of Education to provide intermediate unit boards of directors,…

  1. Unitals in Projective Planes

    CERN Document Server

    Barwick, Susan

    2008-01-01

    Unitals are key structures in projective planes, and have connections with other structures in algebra. This book presents a monograph on unitals embedded in finite projective planes. It offers a survey of the research literature on embedded unitals. It is suitable for graduate students and researchers who want to learn about this topic

  2. Intended Career Choice in Family Medicine in Slovenia: An Issue of Gender, Family Background or Empathic Attitudes in Final Year Medical Students?

    Science.gov (United States)

    Ster, Marija Petek; Selic, Polona

    2017-01-01

    Background: Among a variety of complex factors affecting a decision to take family medicine as a future specialisation, this study focused on demographic characteristics and assessed empathic attitudes in final year medical students. Methods: A convenience sampling method was employed in two consecutive academic years of final year medical students at the Faculty of Medicine in Ljubljana, Slovenia, in May 2014 and May 2015. A modified version of the 16-item Jefferson Scale of Empathy – Student Version (JSE-S) was administered to examine self-reported empathic attitudes. An intended career in family medicine was reported using a five-point Likert scale. Results: Of the 175 medical school seniors in study year 2013/14, there were 64 (36.6%) men and 111 (63.4%) women, while in the second group (study year 2014/5), there were 68 (40.5%) men and 100 (59.5%) women; 168 students in total. They were 24.9±1.6 (generation 2013/4) and 24.9±1.7 (generation 2014/15) years old. Thirty-six percent of the students in the academic year 2013/14 intended to choose family medicine as a future career, and a similar proportion in academic year 2014/15 (31.7%). Gender (χ2=6.763, p=0.034) and empathic attitudes (c2=14.914; p=0.001) had a bivariate association with an intended career choice of family medicine in the 2014/15 generation. When logistic regression was applied to this group of students, an intended career choice in family medicine was associated with empathic attitudes (OR 1.102, 95% CI 1.040-1.167, p=0.001), being single (OR 3.659, 95% CI 1.150-11.628, p=0.028) and the father having only primary school education (OR 142.857 95% CI 1.868, p=0.025), but not with gender (OR 1.117, 95% CI 0.854-1.621, p=0.320). Conclusion: The level of students’ father’s education, and not living in an intimate partnership, increased the odds on senior medical students to choose family medicine, yet we expected higher JSE-S scores to be associated with interest in this speciality. To

  3. The Affordable Care Act: how can we know whether the intended consequences are occurring and the unintended ones are being avoided?

    Science.gov (United States)

    Dubois, Robert W

    2015-04-01

    When the Affordable Care Act (ACA) was signed into law on March 23, 2010, policymakers intended that it would improve access to care by lowering the uninsured rate, improve health care quality, and lower costs. Now, 4 years later, researchers and policymakers need to ask whether those intentions have been realized or whether the ACA has produced unintended consequences that affect patient care. This article raises the importance of assessing what changes in patient access and clinical care have occurred, points out how challenging those assessments may be to conduct, and concludes with a call to action about how those challenges might be addressed.

  4. Successful Army National Guard units: A guard perspective

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, A.K.; Saulsbury, J.W. (Oak Ridge National Lab., TN (United States)); Schexanayder, S.M. (Tennessee Univ., Knoxville, TN (United States))

    1991-10-01

    This project sought to identify factors contributing to a healthy Army National Guard (ARNG) unit. Its results were intended to contribute to a computerized forecasting model under development at Oak Ridge National Laboratory. The model, the ARNG Regional Recruiting Potential Model (RRPM), forecasts locations of successful new or modified Guard units. The study was expected to enhance the understanding of what constituents a healthy Guard unit. A Delphi approach was used to define criteria for healthy Guard units and to elicit rankings of those criteria. Two sets of telephone interviews were conducted with a sample of 102 individuals-two battalion-level administrative officers, or their equivalents, in each state in Washington, DC. During these telephone calls, the phrase unit supportability'' was used to express the notion of a healthy unit. The first set of interviews obtained background information and respondents' ideas of the criteria that lead to unit supportability and to a lack of supportability. The data were analyzed to develop a list of ten criteria for unit supportability. In the second interview, the same respondents were asked to rank those criteria in order of importance.

  5. Successful Army National Guard units: A guard perspective

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, A.K.; Saulsbury, J.W. [Oak Ridge National Lab., TN (United States); Schexanayder, S.M. [Tennessee Univ., Knoxville, TN (United States)

    1991-10-01

    This project sought to identify factors contributing to a healthy Army National Guard (ARNG) unit. Its results were intended to contribute to a computerized forecasting model under development at Oak Ridge National Laboratory. The model, the ARNG Regional Recruiting Potential Model (RRPM), forecasts locations of successful new or modified Guard units. The study was expected to enhance the understanding of what constituents a healthy Guard unit. A Delphi approach was used to define criteria for healthy Guard units and to elicit rankings of those criteria. Two sets of telephone interviews were conducted with a sample of 102 individuals-two battalion-level administrative officers, or their equivalents, in each state in Washington, DC. During these telephone calls, the phrase ``unit supportability`` was used to express the notion of a healthy unit. The first set of interviews obtained background information and respondents` ideas of the criteria that lead to unit supportability and to a lack of supportability. The data were analyzed to develop a list of ten criteria for unit supportability. In the second interview, the same respondents were asked to rank those criteria in order of importance.

  6. Successful Army National Guard units: A guard perspective

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, A.K.; Saulsbury, J.W. (Oak Ridge National Lab., TN (United States)); Schexanayder, S.M. (Tennessee Univ., Knoxville, TN (United States))

    1991-10-01

    This project sought to identify factors contributing to a healthy Army National Guard (ARNG) unit. Its results were intended to contribute to a computerized forecasting model under development at Oak Ridge National Laboratory. The model, the ARNG Regional Recruiting Potential Model (RRPM), forecasts locations of successful new or modified Guard units. The study was expected to enhance the understanding of what constituents a healthy Guard unit. A Delphi approach was used to define criteria for healthy Guard units and to elicit rankings of those criteria. Two sets of telephone interviews were conducted with a sample of 102 individuals-two battalion-level administrative officers, or their equivalents, in each state in Washington, DC. During these telephone calls, the phrase unit supportability'' was used to express the notion of a healthy unit. The first set of interviews obtained background information and respondents' ideas of the criteria that lead to unit supportability and to a lack of supportability. The data were analyzed to develop a list of ten criteria for unit supportability. In the second interview, the same respondents were asked to rank those criteria in order of importance.

  7. Successful Army National Guard units: A guard perspective

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, A.K.; Saulsbury, J.W. [Oak Ridge National Lab., TN (United States); Schexanayder, S.M. [Tennessee Univ., Knoxville, TN (United States)

    1991-10-01

    This project sought to identify factors contributing to a healthy Army National Guard (ARNG) unit. Its results were intended to contribute to a computerized forecasting model under development at Oak Ridge National Laboratory. The model, the ARNG Regional Recruiting Potential Model (RRPM), forecasts locations of successful new or modified Guard units. The study was expected to enhance the understanding of what constituents a healthy Guard unit. A Delphi approach was used to define criteria for healthy Guard units and to elicit rankings of those criteria. Two sets of telephone interviews were conducted with a sample of 102 individuals-two battalion-level administrative officers, or their equivalents, in each state in Washington, DC. During these telephone calls, the phrase ``unit supportability`` was used to express the notion of a healthy unit. The first set of interviews obtained background information and respondents` ideas of the criteria that lead to unit supportability and to a lack of supportability. The data were analyzed to develop a list of ten criteria for unit supportability. In the second interview, the same respondents were asked to rank those criteria in order of importance.

  8. China, Southeast Asia, and the United States

    Directory of Open Access Journals (Sweden)

    Lowell Dittmer

    2016-04-01

    Full Text Available Southeast Asia has historically been a meeting point between East Asia and South Asia before Western colonialism opened the region to the West and to the winds of global modernization. Since Japan’s coercive decolonization during the Second World War, the dominant outside influences have come from the United States and from the People’s Republic of China. The post-Cold War era began with a withdrawal of both China’s and US power projection from Southeast Asia, facilitating the configuration of a triangular ménage à trios, with ASEAN expanding to include all of Southeast Asia and introducing a number of extended forums intended to socialize the rest of East Asia into the ASEAN way. The “rise of China” occurred within this friendly context, though beginning around 2010 its strategic implications began to appear more problematic with the mounting dispute over the issue of the South China Sea.

  9. International Conference on Harmonisation; guidance on S2(R1) Genotoxicity Testing and Data Interpretation for Pharmaceuticals intended for Human Use; availability. Notice.

    Science.gov (United States)

    2012-06-07

    The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled ``S2(R1) Genotoxicity Testing and Data Interpretation for Pharmaceuticals Intended for Human Use'' (ICH S2(R1)). This guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The ICH S2(R1) combines and replaces two ICH guidances, "S2A Specific Aspects for Regulatory Genotoxicity Tests for Pharmaceuticals'' and "S2B Genotoxicity: A Standard Battery for Genotoxicity Testing of Pharmaceuticals.'' ICH S2(R1) provides guidance to drug sponsors on which tests should be performed to assess potential genotoxicity of pharmaceuticals. It also provides guidance on testing conditions, data interpretation, and followup strategies if a positive response is seen in in vitro assays. This guidance is intended to provide drug sponsors with recommendations to ensure that drugs are appropriately tested for potential to cause genetic damage and to ensure efficient development of new drugs.

  10. Unit of measurement used and parent medication dosing errors.

    Science.gov (United States)

    Yin, H Shonna; Dreyer, Benard P; Ugboaja, Donna C; Sanchez, Dayana C; Paul, Ian M; Moreira, Hannah A; Rodriguez, Luis; Mendelsohn, Alan L

    2014-08-01

    Adopting the milliliter as the preferred unit of measurement has been suggested as a strategy to improve the clarity of medication instructions; teaspoon and tablespoon units may inadvertently endorse nonstandard kitchen spoon use. We examined the association between unit used and parent medication errors and whether nonstandard instruments mediate this relationship. Cross-sectional analysis of baseline data from a larger study of provider communication and medication errors. English- or Spanish-speaking parents (n = 287) whose children were prescribed liquid medications in 2 emergency departments were enrolled. Medication error defined as: error in knowledge of prescribed dose, error in observed dose measurement (compared to intended or prescribed dose); >20% deviation threshold for error. Multiple logistic regression performed adjusting for parent age, language, country, race/ethnicity, socioeconomic status, education, health literacy (Short Test of Functional Health Literacy in Adults); child age, chronic disease; site. Medication errors were common: 39.4% of parents made an error in measurement of the intended dose, 41.1% made an error in the prescribed dose. Furthermore, 16.7% used a nonstandard instrument. Compared with parents who used milliliter-only, parents who used teaspoon or tablespoon units had twice the odds of making an error with the intended (42.5% vs 27.6%, P = .02; adjusted odds ratio=2.3; 95% confidence interval, 1.2-4.4) and prescribed (45.1% vs 31.4%, P = .04; adjusted odds ratio=1.9; 95% confidence interval, 1.03-3.5) dose; associations greater for parents with low health literacy and non-English speakers. Nonstandard instrument use partially mediated teaspoon and tablespoon-associated measurement errors. Findings support a milliliter-only standard to reduce medication errors. Copyright © 2014 by the American Academy of Pediatrics.

  11. Ute Unit: Study Guide and Follow Up Activities.

    Science.gov (United States)

    North Conejos School District, Capulin, CO.

    The study guide and follow-up activities were designed primarily to give students a feeling of Ute life in the San Luis Valley in Colorado. The unit begins with six Southern Ute stories about the wolf and coyote, the race between the skunk and the coyote, the frog and the eagle, why the frog croaks, the bear (Que Ye Qat), and the two Indian…

  12. The Republic of Mexico and the United States of America: The Mexican-American War -- In Retrospect. Fulbright-Hays Summer Seminar Abroad 1996 (Mexico).

    Science.gov (United States)

    Juarez, Pablo Hill

    The unit is intended as part of a world cultures curriculum taught at the 10th grade level. The lessons include: (1) "Mexico in Brief"; (2) "The Mexican American War 1846-1848"; and (3) "History and Educational Status of Americans of Mexican Descent (Chicanos) in the Southwest." Additional resources and a 32-item bibliography accompany the unit.…

  13. Planeamiento de la unidad didactica en le ensenanza del ingles como idioma extranjero (Planning the Teaching Unit in the Instruction of English as a Foreign Language).

    Science.gov (United States)

    Medina T., Rene

    1971-01-01

    This paper discusses the use of the teaching unit as a means for organization in English-as-a-foreign-language classes. It lists the essential elements in the construction of such a unit: cultural topic, linguistic elements, time period, main objectives, instructional materials, focus, specific activities, intended results, evaluation techniques,…

  14. 31 CFR 560.511 - Exportation or supply of insubstantial United States content for use in foreign-made products or...

    Science.gov (United States)

    2010-07-01

    ... into a foreign-made end product in a country other than the United States or Iran, intended...-made end product: (i) U.S.-origin goods (excluding software) comprise less than 10 percent of the... insubstantial United States content for use in foreign-made products or technology. 560.511 Section...

  15. Two Curricular Units for Advanced Spanish Students: Guatemala, Ayer y Hoy Descubre Mexico. Fulbright-Hays Summer Seminars Abroad Program, 2000 (Mexico and Guatemala).

    Science.gov (United States)

    Hall, Bonnie L.

    These two curriculum units were developed as a result of study in Mexico and Guatemala during the Fulbright Hays Summer Seminar Abroad Program, 2000. The units are designed for use in an upper-level high school Spanish class. They are intended to be taught in Spanish, and the supplementary materials (with a few exceptions) are written in Spanish.…

  16. Careers (A Course of Study). Unit VII: Now that You've Got the Job--How Do You Keep It?

    Science.gov (United States)

    Turley, Kay

    Designed to enable special needs students to learn how to hold a job and how to change jobs when necessary, this set of activities is the seventh unit in a nine-unit secondary level course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world of work. In the first chapter entitled "How Do I Keep My…

  17. A Stochastic Unit Commitment Model for a Local CHP Plant

    DEFF Research Database (Denmark)

    Ravn, Hans V.; Riisom, Jannik; Schaumburg-Müller, Camilla

    2005-01-01

    Local CHP development in Denmark has during the 90’s been characterised by large growth primarily due to government subsidies in the form of feed-in tariffs. In line with the liberalisation process in the EU, Danish local CHPs of a certain size must operate on market terms from 2005. This paper...... presents a stochastic unit commitment model for a single local CHP plant (consisting of CHP unit, boiler, and heat storage facility) which takes into account varying spot prices. Further, additional technology is implemented in the model in the form of an immersion heater. Simulations are conducted using...

  18. Wartime Interoperability Problems Posed by Differences in South Korean and United States Army Tactics.

    Science.gov (United States)

    1980-06-06

    Tactics. South Korea. 20. AIETIRACT (Cb.bue m ,everme aft f neem and tdenlf by block numbet) See reverse. DO , FA 1473 IEDITOM OF f MOV 65 IS o8SOLET... production ( manufacturing) guerilla units. 12 14 Witn a population less than half that of South Korea’s, and exports amounting to only 7% those of the...personal possessions. These statements are in no way intended to degrade the American officer, but are intended to convey something of the mental attitude of

  19. USGS Small-scale Dataset - 1:1,000,000-Scale Streams of the United States 201403 FileGDB 10.1

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This map layer shows streams of the United States, Puerto Rico, and the U.S. Virgin Islands. The map layer was produced primarily from the Medium-Resolution and...

  20. Natural aggregates of the conterminous United States

    Science.gov (United States)

    Langer, William H.

    1988-01-01

    Crushed stone and sand and gravel are the two main sources of natural aggregates. These materials are commonly used construction materials and frequently can be interchanged with one another. They are widely used throughout the United States, with every State except two producing crushed stone. Together they amount to about half the mining volume in the United States. Approximately 96 percent of sand and gravel and 77 percent of the crushed stone produced in the United States are used in the construction industry. Natural aggregates are widely distributed throughout the United States in a variety of geologic environments. Sand and gravel deposits commonly are the results of the weathering of bedrock and subsequent transportation and deposition of the material by water or ice (glaciers). As such, they commonly occur as river or stream deposits or in glaciated areas as glaciofluvial and other deposits. Crushed stone aggregates are derived from a wide variety of parent bedrock materials. Limestone and other carbonates account for approximately three quarters of the rocks used for crushed stone, with granite and other igneous rocks making up the bulk of the remainder. Limestone deposits are widespread throughout the Central and Eastern United States and are scattered in the West. Granites are widely distributed in the Eastern and Western United States, with few exposures in the Midwest. Igneous rocks (excluding granites) are largely concentrated in the Western United States and in a few isolated localities in the East. Even though natural aggregates are widely distributed throughout the United States, they are not universally available for consumptive use. Some areas are devoid of sand and gravel, and potential sources of crushed stone may be covered with sufficient unconsolidated material to make surface mining impractical. In some areas many aggregates do not meet the physical property requirements for certain uses, or they may contain mineral constituents that react

  1. ENERGY STAR Unit Reports

    Data.gov (United States)

    Department of Housing and Urban Development — These quarterly Federal Fiscal Year performance reports track the ENERGY STAR qualified HOME units that Participating Jurisdictions record in HUD's Integrated...

  2. Proposal for a United Nations Basic Space Technology Initiative

    CERN Document Server

    Balogh, W R

    2012-01-01

    The United Nations Programme on Space Applications, implemented by the United Nations Office for Outer Space Affairs, promotes the benefits of space-based solutions for sustainable economic and social development. The Programme assists Member States of the United Nations to establish indigenous capacities for the use of space technology and its applications. In the past the Programme has primarily been focusing on the use of space applications and on basic space science activities. However, in recent years there has been a strong interest in a growing number of space-using countries to build space technology capacities, for example, the ability to develop and operate small satellites. In reaction to this development, the United Nations in cooperation with the International Academy of Astronautics has been organizing annual workshops on small satellites in the service of developing countries. Space technology related issues have also been addressed as part of various other activities of the Programme on Space ...

  3. 31 CFR 535.321 - United States; continental United States.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States; continental United... General Definitions § 535.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof including the Trust Territory...

  4. 31 CFR 515.321 - United States; continental United States.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States; continental United... General Definitions § 515.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including the Trust Territory...

  5. 31 CFR 500.321 - United States; continental United States.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false United States; continental United... General Definitions § 500.321 United States; continental United States. The term United States means the United States and all areas under the jurisdiction or authority thereof, including U.S. trust...

  6. Evaluation of a laboratory system intended for use in physicians' offices. II. Reliability of results produced by health care workers without formal or professional laboratory training.

    Science.gov (United States)

    Belsey, R; Vandenbark, M; Goitein, R K; Baer, D M

    1987-07-17

    The Kodak DT-60 tabletop chemistry analyzer was evaluated with standardized protocols to determine the system's precision and accuracy when operated by four volunteers (a secretary, a licensed practical nurse, and two family medicine residents) in a simulated office laboratory. The variability of the results was found to be significantly greater than the variability of results produced by medical technologists who analyzed the same samples during the same study period with another DT-60 placed in the hospital laboratory. The source(s) of increased variance needs to be identified so the system can be modified or new control procedures can be developed to ensure the reliability of results used in patient care. Prospective purchasers, manufacturers, and patients need this kind of objective information about the reliability of results produced by systems intended for use in physicians' office laboratories.

  7. Testing the electrostatic characteristics of polypropylene fabric with metallic yarns, intended for use in coal mines threatened by the explosion hazard. Part 2: Tests in coal mine

    Science.gov (United States)

    Talarek, M.; Orzech, L.

    2011-06-01

    The aim of this paper was to assess the electrostatic safety of polypropylene fabric with metallic yarns intended for use in coal mines. Such fabrics have not been used in the Polish mining industry yet. The tests conducted have been divided into two subgroups: laboratory tests and tests in a coal mine. This paper presents the results of tests in a coal mine, where we have focused on the resistance-to-ground in some specific situations. Bags made of fabric at the roadway face were tested, as well as the roll of fabric during transport and carried by a miner. The results obtained allow the reliable assessment of the risk of using fabrics with metallic yarns in the explosive atmosphere which often occurs in coal mines.

  8. Testing the electrostatic characteristics of polypropylene fabric with metallic yarns, intended for use in coal mines threatened by the explosion hazard. Part 2: Tests in coal mine

    Energy Technology Data Exchange (ETDEWEB)

    Talarek, M; Orzech, L, E-mail: mtalarek@komag.eu [KOMAG Institute of Mining Technology, Pszczynska 37, 44-101 Gliwice (Poland)

    2011-06-23

    The aim of this paper was to assess the electrostatic safety of polypropylene fabric with metallic yarns intended for use in coal mines. Such fabrics have not been used in the Polish mining industry yet. The tests conducted have been divided into two subgroups: laboratory tests and tests in a coal mine. This paper presents the results of tests in a coal mine, where we have focused on the resistance-to-ground in some specific situations. Bags made of fabric at the roadway face were tested, as well as the roll of fabric during transport and carried by a miner. The results obtained allow the reliable assessment of the risk of using fabrics with metallic yarns in the explosive atmosphere which often occurs in coal mines.

  9. [Challenges to decentralization and local participation within the health rights protection framework: Experience of the SUSALUD Northern Macro-regional Intendance].

    Science.gov (United States)

    Rebaza-Iparraguirre, Henry; Vela-López, Miguel; Villegas-Ortega, José; Lozada-Urbano, Michelle; Munares-García, Oscar

    2016-01-01

    In Peru, health protection rights and the National Health Authority (SUSALUD) coexist with the aim to ensure that every Peruvian may exercise his/her rights. According to the L.D. (Spanish: Decreto legislativo) N° 1158, strategies must be deployed to ensure effective decentralization and ensure compliance with user rights. As a result, the Northern Macro-regional Intendance (IMRN) was created, with headquarters in the city of Chiclayo, and a coverage area including Lambayeque, Tumbes, Piura, Cajamarca, La Libertad, and Amazonas. The northern macro-region promotes information dissemination, coordination, and local participation in health activities, with an emphasis on handling complaints and claims as well as implementation and operation support of user boards (JUS). After 6 months, implementation of the IMRN experience is undergoing consolidation.

  10. [Optimizing health care using the example of rehabilitation. Intended goals have to be defined and achieved goals have to be confirmed].

    Science.gov (United States)

    Porzsolt, Franz; Zimmermann, Theo

    2010-05-01

    In this article, the authors try to apply the actual problem of health care financing to the area of rehabilitation medicine. It is shown that there are considerable reserves in this system - like in any other area of health care -, which should not be saved but should be rather transformed into efficient health services. If we save these resources, the problems will remain the same but it will be easier to pay for them. If, however, we consider how to generate additional health care values, we will solve more problems than before.The article shows that these improvements require a clear definition of goals of health care. Goals of health care can be attained only if they are defined, and the conditions which have to be met for goal attainment can be identified only if the attained goals are quantified. There is need for action if it is unknown how often intended goals can really be attained.

  11. Antimicrobial activity, antibiotic susceptibility and virulence factors of Lactic Acid Bacteria of aquatic origin intended for use as probiotics in aquaculture

    Directory of Open Access Journals (Sweden)

    Muñoz-Atienza Estefanía

    2013-01-01

    Full Text Available Abstract Background The microorganisms intended for use as probiotics in aquaculture should exert antimicrobial activity and be regarded as safe not only for the aquatic hosts but also for their surrounding environments and humans. The objective of this work was to investigate the antimicrobial/bacteriocin activity against fish pathogens, the antibiotic susceptibility, and the prevalence of virulence factors and detrimental enzymatic activities in 99 Lactic Acid Bacteria (LAB (59 enterococci and 40 non-enterococci isolated from aquatic animals regarded as human food. Results These LAB displayed a broad antimicrobial/bacteriocin activity against the main Gram-positive and Gram-negative fish pathogens. However, particular safety concerns based on antibiotic resistance and virulence factors were identified in the genus Enterococcus (86% (Enterococcus faecalis, 100%; E. faecium, 79%. Antibiotic resistance was also found in the genera Weissella (60%, Pediococcus (44%, Lactobacillus (33%, but not in leuconostocs and lactococci. Antibiotic resistance genes were found in 7.5% of the non-enterococci, including the genera Pediococcus (12.5% and Weissella (6.7%. One strain of both Pediococcus pentosaceus and Weissella cibaria carried the erythromycin resistance gene mef(A/E, and another two P. pentosaceus strains harboured lnu(A conferring resistance to lincosamides. Gelatinase activity was found in E. faecalis and E. faecium (71 and 11%, respectively, while a low number of E. faecalis (5% and none E. faecium exerted hemolytic activity. None enterococci and non-enterococci showed bile deconjugation and mucin degradation abilities, or other detrimental enzymatic activities. Conclusions To our knowledge, this is the first description of mef(A/E in the genera Pediococcus and Weissella, and lnu(A in the genus Pediococcus. The in vitro subtractive screening presented in this work constitutes a valuable strategy for the large-scale preliminary selection of

  12. Presence of Multiple Mycotoxins and Other Fungal Metabolites in Native Grasses from a Wetland Ecosystem in Argentina Intended for Grazing Cattle.

    Science.gov (United States)

    Nichea, María J; Palacios, Sofia A; Chiacchiera, Stella M; Sulyok, Michael; Krska, Rudolf; Chulze, Sofia N; Torres, Adriana M; Ramirez, María L

    2015-08-20

    The aim of this study was to evaluate the occurrence of several fungal metabolites, including mycotoxins in natural grasses (Poaceae) intended for grazing cattle. A total number of 72 and 77 different metabolites were detected on 106 and 69 grass samples collected during 2011 and 2014, respectively. A total of 60 metabolites were found across both years. Among the few mycotoxins considered toxic for ruminants, no samples of natural grasses were contaminated with aflatoxins, ochratoxin A, ergot alkaloids, and gliotoxin, among others. However, we were able to detect important metabolites (toxic to ruminants) such as type A trichothecenes, mainly T-2 toxin and HT-2 toxin (up to 5000 µg/kg each), and zearalenone (up to 2000 µg/kg), all at very high frequencies and levels. Other fungal metabolites that were found to be prevalent were other Fusarium metabolites like beauvericin, equisetin and aurofusarin, metabolites produced by Alternaria spp., sterigmatocystin and its precursors and anthrachinone derivatives. It is important to point out that the profile of common metabolites was shared during both years of sampling, and also that the occurrence of important metabolites is not a sporadic event. Considering that this area of temperate grassland is used for grazing cattle all year long due to the richness in palatable grasses (Poaceae), the present work represents a starting point for further studies on the occurrence of multi-mycotoxins in natural grasses in order to have a complete picture of the extent of cattle exposure. Also, the present study shows that the presence of zeranol in urine of beef cattle may not be a consequence of illegal use of this banned substance, but the product of the natural occurrence of zearalenone and α-zearalenol in natural grasses intended for cattle feeding.

  13. Presence of Multiple Mycotoxins and Other Fungal Metabolites in Native Grasses from a Wetland Ecosystem in Argentina Intended for Grazing Cattle

    Directory of Open Access Journals (Sweden)

    María J. Nichea

    2015-08-01

    Full Text Available The aim of this study was to evaluate the occurrence of several fungal metabolites, including mycotoxins in natural grasses (Poaceae intended for grazing cattle. A total number of 72 and 77 different metabolites were detected on 106 and 69 grass samples collected during 2011 and 2014, respectively. A total of 60 metabolites were found across both years. Among the few mycotoxins considered toxic for ruminants, no samples of natural grasses were contaminated with aflatoxins, ochratoxin A, ergot alkaloids, and gliotoxin, among others. However, we were able to detect important metabolites (toxic to ruminants such as type A trichothecenes, mainly T-2 toxin and HT-2 toxin (up to 5000 µg/kg each, and zearalenone (up to 2000 µg/kg, all at very high frequencies and levels. Other fungal metabolites that were found to be prevalent were other Fusarium metabolites like beauvericin, equisetin and aurofusarin, metabolites produced by Alternaria spp., sterigmatocystin and its precursors and anthrachinone derivatives. It is important to point out that the profile of common metabolites was shared during both years of sampling, and also that the occurrence of important metabolites is not a sporadic event. Considering that this area of temperate grassland is used for grazing cattle all year long due to the richness in palatable grasses (Poaceae, the present work represents a starting point for further studies on the occurrence of multi-mycotoxins in natural grasses in order to have a complete picture of the extent of cattle exposure. Also, the present study shows that the presence of zeranol in urine of beef cattle may not be a consequence of illegal use of this banned substance, but the product of the natural occurrence of zearalenone and α-zearalenol in natural grasses intended for cattle feeding.

  14. Antimicrobial activity, antibiotic susceptibility and virulence factors of Lactic Acid Bacteria of aquatic origin intended for use as probiotics in aquaculture

    Science.gov (United States)

    2013-01-01

    Background The microorganisms intended for use as probiotics in aquaculture should exert antimicrobial activity and be regarded as safe not only for the aquatic hosts but also for their surrounding environments and humans. The objective of this work was to investigate the antimicrobial/bacteriocin activity against fish pathogens, the antibiotic susceptibility, and the prevalence of virulence factors and detrimental enzymatic activities in 99 Lactic Acid Bacteria (LAB) (59 enterococci and 40 non-enterococci) isolated from aquatic animals regarded as human food. Results These LAB displayed a broad antimicrobial/bacteriocin activity against the main Gram-positive and Gram-negative fish pathogens. However, particular safety concerns based on antibiotic resistance and virulence factors were identified in the genus Enterococcus (86%) (Enterococcus faecalis, 100%; E. faecium, 79%). Antibiotic resistance was also found in the genera Weissella (60%), Pediococcus (44%), Lactobacillus (33%), but not in leuconostocs and lactococci. Antibiotic resistance genes were found in 7.5% of the non-enterococci, including the genera Pediococcus (12.5%) and Weissella (6.7%). One strain of both Pediococcus pentosaceus and Weissella cibaria carried the erythromycin resistance gene mef(A/E), and another two P. pentosaceus strains harboured lnu(A) conferring resistance to lincosamides. Gelatinase activity was found in E. faecalis and E. faecium (71 and 11%, respectively), while a low number of E. faecalis (5%) and none E. faecium exerted hemolytic activity. None enterococci and non-enterococci showed bile deconjugation and mucin degradation abilities, or other detrimental enzymatic activities. Conclusions To our knowledge, this is the first description of mef(A/E) in the genera Pediococcus and Weissella, and lnu(A) in the genus Pediococcus. The in vitro subtractive screening presented in this work constitutes a valuable strategy for the large-scale preliminary selection of putatively safe LAB

  15. Presence of Multiple Mycotoxins and Other Fungal Metabolites in Native Grasses from a Wetland Ecosystem in Argentina Intended for Grazing Cattle

    Science.gov (United States)

    Nichea, María J.; Palacios, Sofia A.; Chiacchiera, Stella M.; Sulyok, Michael; Krska, Rudolf; Chulze, Sofia N.; Torres, Adriana M.; Ramirez, María L.

    2015-01-01

    The aim of this study was to evaluate the occurrence of several fungal metabolites, including mycotoxins in natural grasses (Poaceae) intended for grazing cattle. A total number of 72 and 77 different metabolites were detected on 106 and 69 grass samples collected during 2011 and 2014, respectively. A total of 60 metabolites were found across both years. Among the few mycotoxins considered toxic for ruminants, no samples of natural grasses were contaminated with aflatoxins, ochratoxin A, ergot alkaloids, and gliotoxin, among others. However, we were able to detect important metabolites (toxic to ruminants) such as type A trichothecenes, mainly T-2 toxin and HT-2 toxin (up to 5000 µg/kg each), and zearalenone (up to 2000 µg/kg), all at very high frequencies and levels. Other fungal metabolites that were found to be prevalent were other Fusarium metabolites like beauvericin, equisetin and aurofusarin, metabolites produced by Alternaria spp., sterigmatocystin and its precursors and anthrachinone derivatives. It is important to point out that the profile of common metabolites was shared during both years of sampling, and also that the occurrence of important metabolites is not a sporadic event. Considering that this area of temperate grassland is used for grazing cattle all year long due to the richness in palatable grasses (Poaceae), the present work represents a starting point for further studies on the occurrence of multi-mycotoxins in natural grasses in order to have a complete picture of the extent of cattle exposure. Also, the present study shows that the presence of zeranol in urine of beef cattle may not be a consequence of illegal use of this banned substance, but the product of the natural occurrence of zearalenone and α-zearalenol in natural grasses intended for cattle feeding. PMID:26308052

  16. REACH. Air Conditioning Units.

    Science.gov (United States)

    Garrison, Joe; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of air conditioning. The instructional units focus on air conditioning fundamentals, window air conditioning, system and installation, troubleshooting and…

  17. REACH. Air Conditioning Units.

    Science.gov (United States)

    Garrison, Joe; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of air conditioning. The instructional units focus on air conditioning fundamentals, window air conditioning, system and installation, troubleshooting and…

  18. REACH. Refrigeration Units.

    Science.gov (United States)

    Snow, Rufus; And Others

    As a part of the REACH (Refrigeration, Electro-Mechanical, Air-Conditioning, Heating) electromechanical cluster, this student manual contains individualized instructional units in the area of refrigeration. The instructional units focus on refrigeration fundamentals, tubing and pipe, refrigerants, troubleshooting, window air conditioning, and…

  19. Unit on Existentialism.

    Science.gov (United States)

    Rowell, Bobby

    1971-01-01

    A unit on existentialism is suggested to counteract the indifferent attitude that students have toward much of the literature with which they are presented. The key to a successful literature unit is immediate and total student involvement. Topics, authors, and works which may be used to arouse student interest are presented. (CK)

  20. Out of Many, One: European film-makers construct the United States

    Directory of Open Access Journals (Sweden)

    Dominique Sipière

    2010-11-01

    Full Text Available The Latin phrase e pluribus unum (out of many, one was the motto proposed by John Adams, Benjamin Franklin and Thomas Jefferson for the first Seal of the United States in 1776. It would later be included on most American currency and in the Seal of the President of the United States. Originally intended to suggest that out of the thirteen independent states declaring their independence from Britain would emerge a single country, it would later imply that the United States was attempting to ...

  1. United States-Mexico electricity transfers: Of alien electrons and the migration of undocumented environmental burdens

    Energy Technology Data Exchange (ETDEWEB)

    Gandara, A. [Univ. of California, Davis, CA (United States)

    1995-08-01

    This article intends to set forth the necessity for reform in the United States policy and procedures regarding approval of power transfers between the United States and Mexico. In order to do this, the article will review the history of electrical power transfers between the United States and Mexico (Part II), analyze recent regulatory changes in the United States and Mexico which may result in increased power exports to Mexico (Part III), evaluate the extent to which the present permit and authorization system in the United States considers the increased environmental burden of such power transfers (Part IV), and, where appropriate, propose some procedural and policy reforms that could take into account the environmental burdens generated by the production of power destined for transfer across the United States-Mexico border (Part V).

  2. Unità e concordanza teleologica del mondo in Kant

    Directory of Open Access Journals (Sweden)

    Gerardo Cunico

    2015-11-01

    Full Text Available L’articolo tratta la concezione dell’armonia di Kant nel suo significato ontologico fondamentale, ossia nel senso di quella concordanza teleologica che era al centro della metafisica dogmatica e che Kant intende decostruire criticamente e ricostruire su un piano non più teoretico-speculativo, ma teleologico-morale. Gli argomenti fondamentali di questa ricostruzione vengono presentati e discussi esaminando il modo in cui Kant rielabora il concetto di mondo come unità degli enti finiti concepibile solo come concordanza finalistica.

  3. Coordinator(a) de Servicios Clinicos. Parte I (Unidad I-IV). Parte II (Unidad V-VI). Guia. Documento de Trabajo (Clinical Services Coordinator. Part I. Units I-IV. Part II. Units V-VI. Guide. Working Document).

    Science.gov (United States)

    Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

    This guide is intended for instructing secondary students in the occupation of clinical services coordinator in a hospital. The first part contains four units on the following subjects: the occupation of clinical services coordinator; interpersonal relationships; ethical/legal aspects; and communications (telephone, intercom, and others). For each…

  4. Coordinator(a) de Servicios Clinicos. Parte I (Unidad I-IV). Parte II (Unidad V-VI). Guia. Documento de Trabajo (Clinical Services Coordinator. Part I. Units I-IV. Part II. Units V-VI. Guide. Working Document).

    Science.gov (United States)

    Puerto Rico State Dept. of Education, Hato Rey. Area for Vocational and Technical Education.

    This guide is intended for instructing secondary students in the occupation of clinical services coordinator in a hospital. The first part contains four units on the following subjects: the occupation of clinical services coordinator; interpersonal relationships; ethical/legal aspects; and communications (telephone, intercom, and others). For each…

  5. Le système des intendances dans les Indes Occidentales : son impact sur le Trésor Royal

    Directory of Open Access Journals (Sweden)

    Manuela Domínguez-Orta

    2012-01-01

    Full Text Available Pendant la seconde moitié du XVIIIe siècle, l’une des réformes entreprises par la monarchie espagnole dans les Indes Occidentales fut l’établissement d’un système d’intendances. L’objectif de ce travail est d’analyser l’influence des intendances dans les finances royales, en s’intéressant au rôle qu’elles devaient jouer en matière de contrôle financier. Notre recherche porte sur la vice-royauté du Río de la Plata, car c’est là que les intendances furent établies avec succès avant d’être étendues au reste des territoires espagnols de l’Amérique.El presente estudio se contextualiza en la segunda mitad del siglo XVIII en las Indias Occidentales. Durante este período una de las reformas que llevó a cabo la Monarquía española en sus posesiones ultramarinas fue el establecimiento del sistema de intendencias. El objetivo de este trabajo es analizar la influencia de las intendencias en la Hacienda Real a través de aspectos contables. Como caso de estudio se ha tomado el Virreinato del Río de la Plata por haber sido el Virreinato en el que las intendencias se establecieron con éxito y desde donde se extendieron al resto de los territorios americanos.Der Artikel interessiert sich für den Verwaltungsaufbau der Intendanten, der zielt, ab 1700 den Kontrolle des spanischen Reiches zu verbessern, um die königlichen Einnahmen zu erhöhen. Der französische Einfluß hat in dieser Entstehung der Intendanten gelastet. Tatsächlich findet man, daß ihre Einführung auf der Iberischen Halbinsel während erster Hälfte des XVIII. Jahrhunderts von Jean Orry und ihren Mitarbeitern das Verdienst ist. Später sind die Intendanten in spanischem Amerika angesiedelt gewesen, und man rechtfertigte diese Verbreitung seit der Metropole von den Vorteilen, daß “die königlichen Finanzen, in der besten Verwaltung der Einnahmen erhalten hatten”. Bis hierher sind die Intendanten von unterschiedlichen Seiten studiert gewesen

  6. United nations Orchestra

    CERN Multimedia

    MusiClub

    MusiClub United nations Orchestra www.ungenevaorchestra.ch An organizing committee has taken the initiative to create an Orchestra of the united nations at Geneva. In the context of this initiative, musicians in the following categories are invited to become members of the Orchestra and the Association: Active or retired staff of International organizations in Geneva; Active or retired employees of Permanent Missions to the United Nations at Geneva; as well as children and spouses of the above persons. For enrolment or for additional information, please contact: un.orchestra@yahoo.com

  7. Instrument repair for remote eye units

    Directory of Open Access Journals (Sweden)

    Sam Powdrill

    2004-10-01

    Full Text Available Many skilled eye surgeons in remote hospitals face the frustration that a simple instrument, once in good working order, is now bent or broken. Many eye units have a box containing instruments needing repair, hidden away in a stock room cupboard, in the hope that someone, someday, will be able to redeem them. This article gives guidelines on: 1 How to assess instruments and identify those that can be repaired locally, those that should be sent to a professional repair service and those that cannot be repaired at all. 2 How to make adjustments and carry out basic maintenance and repairs of surgical instruments. The article will refer primarily to instruments in an extracapsular cataract extraction set.

  8. Are freestanding midwifery units a safe alternative to obstetric units for low-risk, primiparous childbirth?:An analysis of effect differences by parity in a matched cohort study

    OpenAIRE

    Christensen, Louise Fischer; Overgaard, Charlotte

    2017-01-01

    Background Intrapartum complications and the use of obstetric interventions are more common in primiparous childbirth than in multiparous childbirth, leading to concern about out of hospital birth for primiparous women. The purpose of this study was to determine whether the effect of birthplace on perinatal and maternal morbidity and the use of obstetric interventions differed by parity among low-risk women intending to give birth in a freestanding midwifery unit or in an obstetric unit in th...

  9. The regulation in the unitization process in the petroleum and natural gas exploration in Brazil; A regulacao no processo de unitization na exploracao de petroleo e gas natural no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, Felipe Alvite; Silva, Moises Espindola [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Engenharia de Petroleo; Bone, Rosemarie Broeker [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Engenharia de Producao

    2008-07-01

    This paper presents and analyses the unitization of exploration and production process of petroleum and natural gas in Brazil, focusing the regulatory aspects under the Petroleum Law 9478/97. Considering the deficiency and blanks of the existent regulation when referring the utilization, this work intends to present and discuss those non resolved points and, in concise way, to present international unitization cases, applying when possible, their resolutions to Brazil.

  10. 自拟降脂汤治疗高脂血症30例%30 Cases of Treating Hyperlipidemia with self-Intended Lipid lowering Decoction

    Institute of Scientific and Technical Information of China (English)

    赵慧群; 韩冰

    2015-01-01

    Objective:To observe the efficacy of self-Intended Lipid lowering Decoction treatment of hyperlipidemia.Methods:60 patients with hyperlipidemia were randomized divided into two groups of 30 patients. The contrast group with diet and lifestyle interventions, the treatment group received the treatment of Chinese traditional medicine—taking the self-Intended Lipid lowering Decoction. After 4 weeks make a statistical about the content of TC, TG ,HDL - C, LDL - C before and after treatment.Results:In 60 cases, there is no significant difference between the content of TC, TG ,HDL - C, LDL - C treatment group and contrast group (P>0.05), and after treatment treatment group was lower than before treatment (P0.05).Conclusion:The direct cause of hyperlipidemia phlegm indigestion, taking into account the root causes of deficiency of the liver and kidney, the choice of eliminating dampness ,resolving turbidity and huaji, drugs of replenishing liver and kidney to reach not only temporary purpose but also permanent cure.%目的:观察“自拟降脂汤”治疗高脂血症的疗效。方法:将60例高脂血症患者随机分为治疗组与对照组各30例,对照组给予饮食及生活习惯干预,治疗组给予“自拟降脂汤”口服。服药4周后统计治疗前后TC、TG、HDL-C、LDL-C含量。结果:在60例病例中,治疗组TC、TG、HDL-C、LDL-C与对照组无明显区别(P>0.05),并且治疗组治疗后低于治疗前(P0.05)。结论:针对高脂血症的直接病因痰浊食积,兼顾肝肾亏虚的根本原因,选用利湿降浊化积、补益肝肾之药物达到标本兼治的目的。

  11. Large-Scale Avian Influenza Surveillance in Wild Birds throughout the United States

    OpenAIRE

    Bevins, Sarah N.; Pedersen, Kerri; Lutman, Mark W.; Baroch, John A.; Schmit, Brandon S.; Kohler, Dennis; Gidlewski, Thomas; Nolte, Dale L.; Swafford, Seth R.; DeLiberto, Thomas J

    2014-01-01

    Avian influenza is a viral disease that primarily infects wild and domestic birds, but it also can be transmitted to a variety of mammals. In 2006, the United States of America Departments of Agriculture and Interior designed a large-scale, interagency surveillance effort that sought to determine if highly pathogenic avian influenza viruses were present in wild bird populations within the United States of America. This program, combined with the Canadian and Mexican surveillance programs, rep...

  12. Teaching Mass Transfer and Filtration Using Crossflow Reverse Osmosis and Nanofiltration: An Experiment for the Undergraduate Unit Operations Lab

    Science.gov (United States)

    Anastasio, Daniel; McCutcheon, Jeffrey

    2012-01-01

    A crossflow reverse osmosis (RO) system was built for a senior-level chemical engineering unit operations laboratory course. Intended to teach students mass transfer fundamentals related to membrane separations, students tested several commercial desalination membranes, measuring water flux and salt rejections at various pressures, flow rates, and…

  13. Teaching Mass Transfer and Filtration Using Crossflow Reverse Osmosis and Nanofiltration: An Experiment for the Undergraduate Unit Operations Lab

    Science.gov (United States)

    Anastasio, Daniel; McCutcheon, Jeffrey

    2012-01-01

    A crossflow reverse osmosis (RO) system was built for a senior-level chemical engineering unit operations laboratory course. Intended to teach students mass transfer fundamentals related to membrane separations, students tested several commercial desalination membranes, measuring water flux and salt rejections at various pressures, flow rates, and…

  14. William Wales and the 1769 Transit of Venus: Puzzle Solving and the Determination of the Astronomical Unit

    Science.gov (United States)

    Metz, Don

    2009-01-01

    According to Thomas Kuhn, a significant part of "normal science" is the fact gathering, empirical work which is intended to illustrate an existing paradigm. Some of this effort focuses on the determination of physical constants such as the astronomical unit (AU). For Kuhn, normal science is also what prepares students for membership in a…

  15. Universal Beliefs and Specific Practices: Students' Math Self-Efficacy and Related Factors in the United States and China

    Science.gov (United States)

    Wu, Yin

    2016-01-01

    This study intends to compare and contrast student and school factors that are associated with students' mathematics self-efficacy in the United States and China. Using hierarchical linear regressions to analyze the Programme for International Student Assessment (PISA) 2012 data, this study compares math self-efficacy, achievement, and variables…

  16. India: General Survey Unit for World Civilization Course Curriculum Project. Fulbright-Hays Summer Seminars Abroad, 1997 (India).

    Science.gov (United States)

    Brinton, Victoria

    This unit is intended to provide high school students with a general knowledge of the history and culture of India. Lessons include: (1) "Early India"; (2) "Indian Civilization 1500 BC - 500 AD: Hinduism"; (3) "Buddhism"; (4) "Indian Empires"; (5) "Indian Empires, Continued"; (6)…

  17. 76 FR 70480 - Otay River Estuary Restoration Project, South San Diego Bay Unit of the San Diego Bay National...

    Science.gov (United States)

    2011-11-14

    ... Fish and Wildlife Service Otay River Estuary Restoration Project, South San Diego Bay Unit of the San Diego Bay National Wildlife Refuge, California; Environmental Impact Statement AGENCY: Fish and Wildlife... the San Diego Bay National Wildlife Refuge. This notice advises the public that we intend to gather...

  18. Does size matter? Animal units and animal unit months

    Science.gov (United States)

    Lamar Smith; Joe Hicks; Scott Lusk; Mike Hemmovich; Shane Green; Sarah McCord; Mike Pellant; John Mitchell; Judith Dyess; Jim Sprinkle; Amanda Gearhart; Sherm Karl; Mike Hannemann; Ken Spaeth; Jason Karl; Matt Reeves; Dave Pyke; Jordan Spaak; Andrew Brischke; Del Despain; Matt Phillippi; Dave Weixelmann; Alan Bass; Jessie Page; Lori Metz; David Toledo; Emily Kachergis

    2017-01-01

    The concepts of animal units, animal unit months, and animal unit equivalents have long been used as standards for range management planning, estimating stocking rates, reporting actual use, assessing grazing fees, ranch appraisal, and other purposes. Increasing size of cattle on rangelands has led some to suggest that the definition of animal units and animal unit...

  19. Reasons for changes in the value of unit pressure of compression products supporting external treatment

    Science.gov (United States)

    Kowalski, K.; Ilska, A.; Kłonowska, M.

    2016-07-01

    The paper presents the basics of modelling compression products with intended values of unit pressure for body circumferences with fixed and variable radius of curvature. The derived relationships referring to the dimensions of the fabric's circumferences in a relaxed state of the product were based on Laplace law, local values of the radius of curvature, and the characteristics of stretching and relaxing (deformation) of the knitted fabric, described by experimental relation for the stress and relaxation phase for the 6th hysteresis loop, taking into account confidence intervals. The article indicates the possibilities of using 3D scanning techniques of the human body to identify the radius of curvature of various circumference of the human silhouette, for which the intended value of the unit pressure is designed, and quantitative changes in the body deformation due to compression. Classic method of modelling and design of compression products, based on a cylindrical model of the human body does not provide in each case the intended value of unit pressure, according to specific normative requirements, because it neglects the effect of different values of the radius of curvature of the body circumference and the properties of the viscoelastic knitted fabrics. The model and experimental research allowed for a quantitative and qualitative assessment of the reasons for the changes in the value of unit pressure of compression products supporting the process of external treatment.

  20. Tax Unit Boundaries

    Data.gov (United States)

    Kansas Data Access and Support Center — The Statewide GIS Tax Unit boundary file was created through a collaborative partnership between the State of Kansas Department of Revenue Property Valuation...