Logic without unique readability - a study of semantic and syntactic ambiguity

DEFF Research Database (Denmark)

Bentzen, Martin Mose

One of the main reasons for introducing a formal language is to remove ambiguity, the possibility of assigning several meanings to a linguistic expression. Typically, this is achieved through ensuring unique readability of formulas by using brackets (or another convention, such as Polish notation...... not hold true universally. Whereas e.g. scope ambiguities in natural languages have been studied extensively, ambiguous formal languages have not been the focus of in depth research. Here, we lift the assumption of unique readability by omitting the brackets from propositional logic, making it possible...... to formally distinguish between syntactic and semantic ambiguity. A valuation then amounts to a semantic disambiguation, and rather than a unique valuation (truth value), there is a set of valuations corresponding to ways a formula could have been constructed. We show what happens to familiar concepts...

Design process and modeling studies of SSRL beam line wunder

International Nuclear Information System (INIS)

Bachrach, R.Z.; Bringans, R.D.

1984-01-01

SSRL Beam Line Wunder will be the first soft X-ray energy range synchrotron radiation beam line specifically designed to exploit the unique aspects of periodic insertion devices in the wiggler-undulator (wunder) regime. Aspects of the development of this beam line are described in this paper and in particular, we discuss the design methodology adopted and emphasize the joint optical, thermal and mechanical optimization studies that were required. (orig.)

Brush-Like Polymers: New Design Platforms for Soft, Dry Materials with Unique Property Relations

Science.gov (United States)

Daniel, William Francis McKemie, Jr.

Elastomers represent a unique class of engineering materials due to their light weight, low cost, and desirable combination of softness (105 -107 Pa) and large extensibilities (up to 1000%). Despite these advantages, there exist applications that require many times softer modulus, greater extensibility, and stronger strain hardening for the purpose of mimicking the mechanical properties of systems such as biological tissues. Until recently, only liquid-filled gels were suitable materials for such applications, including soft robotics and implants. A considerable amount of work has been done to create gels with superior properties, but despite unique strengths they also suffer from unique weaknesses. This class of material displays fundamental limitations in the form of heterogeneous structures, solvent loss and phase transitions at extreme temperatures, and loss of liquid fraction upon high deformations. In gels the solvent fraction also introduces a large solvent/polymer interaction parameter which must be carefully considered when designing the final mechanical properties. These energetic considerations further exaggerate the capacity for inconstant mechanical properties caused by fluctuations of the solvent fraction. In order to overcome these weaknesses, a new platform for single component materials with low modulus (Standard networks have one major control factor outside of chemistry, the network stand length. Brush-like architectures are created from long strands with regularly grafted side chains creating three characteristic length scales which may be independently manipulated. In collaboration with M. Rubinstein, we have utilized bottlebrush polymer architectures (a densely grafted brush-like polymer) to experimentally verify theoretical predictions of disentangled bottlebrush melts. By attaching well-defined side chains onto long polymer backbones, individual polymer strands are separated in space (similar to dilution with solvent) accompanied by a

ELMO Bumpy Torus fusion-reactor design study

International Nuclear Information System (INIS)

Bathke, C.G.; Krakowski, R.A.

1981-01-01

A complete power plant design of a 1200-MWe ELMO Bumpy Torus Reactor (EBTR) is described that emphasizes those features that are unique to the EBT confinement concept, with subsystems and balance-of-plant items that are generic to magnetic fusion being adopted from past, more extensive tokamak reactor designs

The unique role of halogen substituents in the design of modern agrochemicals.

Science.gov (United States)

Jeschke, Peter

2010-01-01

The past 30 years have witnessed a period of significant expansion in the use of halogenated compounds in the field of agrochemical research and development. The introduction of halogens into active ingredients has become an important concept in the quest for a modern agrochemical with optimal efficacy, environmental safety, user friendliness and economic viability. Outstanding progress has been made, especially in synthetic methods for particular halogen-substituted key intermediates that were previously prohibitively expensive. Interestingly, there has been a rise in the number of commercial products containing 'mixed' halogens, e.g. one or more fluorine, chlorine, bromine or iodine atoms in addition to one or more further halogen atoms. Extrapolation of the current trend indicates that a definite growth is to be expected in fluorine-substituted agrochemicals throughout the twenty-first century. A number of these recently developed agrochemical candidates containing halogen substituents represent novel classes of chemical compounds with new modes of action. However, the complex structure-activity relationships associated with biologically active molecules mean that the introduction of halogens can lead to either an increase or a decrease in the efficacy of a compound, depending on its changed mode of action, physicochemical properties, target interaction or metabolic susceptibility and transformation. In spite of modern design concepts, it is still difficult to predict the sites in a molecule at which halogen substitution will result in optimal desired effects. This review describes comprehensively the successful utilisation of halogens and their unique role in the design of modern agrochemicals, exemplified by various commercial products from Bayer CropScience coming from different agrochemical areas.

IDGenerator: unique identifier generator for epidemiologic or clinical studies

Directory of Open Access Journals (Sweden)

Matthias Olden

2016-09-01

Full Text Available Abstract Background Creating study identifiers and assigning them to study participants is an important feature in epidemiologic studies, ensuring the consistency and privacy of the study data. The numbering system for identifiers needs to be random within certain number constraints, to carry extensions coding for organizational information, or to contain multiple layers of numbers per participant to diversify data access. Available software can generate globally-unique identifiers, but identifier-creating tools meeting the special needs of epidemiological studies are lacking. We have thus set out to develop a software program to generate IDs for epidemiological or clinical studies. Results Our software IDGenerator creates unique identifiers that not only carry a random identifier for a study participant, but also support the creation of structured IDs, where organizational information is coded into the ID directly. This may include study center (for multicenter-studies, study track (for studies with diversified study programs, or study visit (baseline, follow-up, regularly repeated visits. Our software can be used to add a check digit to the ID to minimize data entry errors. It facilitates the generation of IDs in batches and the creation of layered IDs (personal data ID, study data ID, temporary ID, external data ID to ensure a high standard of data privacy. The software is supported by a user-friendly graphic interface that enables the generation of IDs in both standard text and barcode 128B format. Conclusion Our software IDGenerator can create identifiers meeting the specific needs for epidemiologic or clinical studies to facilitate study organization and data privacy. IDGenerator is freeware under the GNU General Public License version 3; a Windows port and the source code can be downloaded at the Open Science Framework website: https://osf.io/urs2g/ .

Plutonium uniqueness

International Nuclear Information System (INIS)

Silver, G.L.

1984-01-01

A standard is suggested against which the putative uniqueness of plutonium may be tested. It is common folklore that plutonium is unique among the chemical elements because its four common oxidation states can coexist in the same solution. Whether this putative uniqueness appears only during transit to equilibrium, or only at equilibrium, or all of the time, is not generally made clear. But while the folklore may contain some truth, it cannot be put to test until some measure of 'uniqueness' is agreed upon so that quantitative comparisons are possible. One way of measuring uniqueness is as the magnitude of the product of the mole fractions of the element at equilibrium. A 'coexistence index' is defined and discussed. (author)

A Case Study in Classroom Management and School Involvement: Designing an Art Room for Effective Learning

Science.gov (United States)

Broome, Jeffrey L.

2013-01-01

The purpose of this research project is to investigate the design of classroom environments through the lens of a uniquely selected art educator. More specifically, the purpose is to use case study methodology (Stake, 1995) to characterize the resulting instructional experiences for an art educator who had the unique opportunity to collaborate…

Plastic-casting intrinsic-surface unique identifier (tag)

International Nuclear Information System (INIS)

Palm, R.G.; De Volpi, A.

1995-04-01

This report describes the development of an authenticated intrinsic-surf ace tagging method for unique- identification of controlled items. Although developed for control of items limited by an arms control treaty, this method has other potential applications to keep track of critical or high-value items. Each tag (unique-identifier) consists of the intrinsic, microscopic surface topography of a small designated area on a controlled item. It is implemented by making a baseline plastic casting of the designated tag area and usually placing a cover (for example, a bar-code label) over this area to protect the surface from environmental alteration. The plastic casting is returned to a laboratory and prepared for high-resolution scanning electron microscope imaging. Several images are digitized and stored for use as a standard for authentication of castings taken during future inspections. Authentication is determined by numerically comparing digital images. Commercially available hardware and software are used for this tag. Tag parameters are optimized, so unique casting images are obtained from original surfaces, and images obtained from attempted duplicate surfaces are detected. This optimization uses the modulation transfer function, a first principle of image analysis, to determine the parameters. Surface duplication experiments confirmed the optimization

Using Quantum Confinement to Uniquely Identify Devices

Science.gov (United States)

Roberts, J.; Bagci, I. E.; Zawawi, M. A. M.; Sexton, J.; Hulbert, N.; Noori, Y. J.; Young, M. P.; Woodhead, C. S.; Missous, M.; Migliorato, M. A.; Roedig, U.; Young, R. J.

2015-11-01

Modern technology unintentionally provides resources that enable the trust of everyday interactions to be undermined. Some authentication schemes address this issue using devices that give a unique output in response to a challenge. These signatures are generated by hard-to-predict physical responses derived from structural characteristics, which lend themselves to two different architectures, known as unique objects (UNOs) and physically unclonable functions (PUFs). The classical design of UNOs and PUFs limits their size and, in some cases, their security. Here we show that quantum confinement lends itself to the provision of unique identities at the nanoscale, by using fluctuations in tunnelling measurements through quantum wells in resonant tunnelling diodes (RTDs). This provides an uncomplicated measurement of identity without conventional resource limitations whilst providing robust security. The confined energy levels are highly sensitive to the specific nanostructure within each RTD, resulting in a distinct tunnelling spectrum for every device, as they contain a unique and unpredictable structure that is presently impossible to clone. This new class of authentication device operates with minimal resources in simple electronic structures above room temperature.

A core design study for 'zero-sodium-void-worth' cores

International Nuclear Information System (INIS)

Kawashima, Masatoshi; Suzuki, Masao; Hill, R.N.

1992-01-01

Recently, a number of low sodium-void-worth metal-fueled core design concepts have been proposed; to provide for flexibility in transuranic nuclide management strategy, core designs which exhibit a wide range of breeding characteristics have been developed. Two core concepts, a flat annular (transuranic burning) core and an absorber-type parfait (transuranic self-sufficient) core, are selected for this study. In this paper, the excess reactivity management schemes applied in the two designs are investigated in detail. In addition, the transient effect of reactivity insertions on the parfait core design is assessed. The upper and lower core regions in the parfait design are neutronically decoupled; however, the common coolant channel creates thermalhydraulic coupling. This combination of neutronic and thermalhydraulic characteristics leads to unique behavior in anticipated transient overpower events. (author)

Studying visual and spatial reasoning for design creativity

CERN Document Server

2015-01-01

Creativity and design creativity in particular are being recognized as playing an increasing role in the social and economic wellbeing of a society. As a consequence creativity is becoming a focus of research. However, much of this burgeoning research is distributed across multiple disciplines that normally do not intersect with each other and researchers in one discipline are often unaware of related research in another discipline.  This volume brings together contributions from design science, computer science, cognitive science and neuroscience on studying visual and spatial reasoning applicable to design creativity. The book is the result of a unique NSF-funded workshop held in Aix-en-Provence, France. The aim of the workshop and the resulting volume was to allow researchers in disparate disciplines to be exposed to the other’s research, research methods and research results within the context of design creativity. Fifteen of the papers presented and discussed at the workshop are contained in this volu...

Electric-powered passenger vehicle design study program. Task 1. Tradeoff studies

Energy Technology Data Exchange (ETDEWEB)

Rowlett, B.H.

1976-09-16

Using the baseline vehicle and power system design established previously to meet the performance goals of the program, three power system computer simulation programs were prepared for the basic vehicle tradeoff studies. These programs simulate the performance of the power system and vehicle over different types of driving conditions such as maximum power acceleration, deceleration, city driving cycles, and hill climbing, and permit accurate determination of the benefits of the unique hybrid power system, the total energy required for the suburban city driving cycle, and the extremes of the operating envelopes of the components so that component design options can be defined and studied. Component design tradeoff studies were conducted, including sensitivity studies to show the criticality of the various losses and unknowns in the analytical models. Also, preliminary vehicle layout studies were performed to determine the best locations of the power system and the batteries. Three basic design options are identified for further study. Economic studies were initiated using analytical models to establish the complete vehicle weight and cost breakdowns. Preliminary reliability and safety studies were completed, and maintainability and safety certification criteria established. The detailed analysis of the power system has verified the feasibility of the system and of the performance expectations. Also, the feasibility of energy recovery from regenerative braking has been confirmed. The sensitivity analysis of the power system shows that sufficient margin for unknown design variables is provided. The preliminary economic analysis indicates that the most difficult objective of the study will be the selection of the cost and weight relationships which are required to achieve the overall cost objectives.

Collaboration within Student Design Teams Participating in Architectural Design Competitions

Science.gov (United States)

Erbil, Livanur; Dogan, Fehmi

2012-01-01

This paper investigates design collaboration with reference to convergent and divergent idea generation processes in architectural design teams entering a design competition. Study of design teams offer a unique opportunity to investigate how creativity is fostered through collaborative work. While views of creativity often relate creativity to…

A unique structure for the multiplexer in quantum-dot cellular automata to create a revolution in design of nanostructures

Energy Technology Data Exchange (ETDEWEB)

Naji Asfestani, Mazaher; Rasouli Heikalabad, Saeed, E-mail: s.rasouli@iaut.ac.ir

2017-05-01

Quantum-dot cellular automata (QCA) is the advent of technology and suitable replacement for semiconductor transistor technology. In this paper, a unique structure for the 2:1 multiplexer is presented in QCA. The structure of this component is simple, ultra-efficient and very useful to implement the various logical functions. The proposed structure does not follow any Boolean function. It takes advantage of the inherent characteristics of quantum technology to produce the desired output. Based on these principles, we design the new and efficient structures for the 4:1 multiplexer and 8:1 multiplexer in the QCA technology. These structures are designed with QCADesigner simulator and simulation results are examined. Investigation results indicate the amazing performance of proposed structure compared to existing structures in terms of area, complexity, power consumption and latency.

Designing and Implementing a Unique Website Design Project in an Undergraduate Course

Science.gov (United States)

Kontos, George

2016-01-01

The following paper describes a distinctive collaborative service-learning project done in an undergraduate class on web design. In this project, students in a web design class contacted local community non-profit organizations to create websites (collections of web pages) to benefit these organizations. The two phases of creating a website,…

The Validity and Precision of the Comparative Interrupted Time-Series Design: Three Within-Study Comparisons

Science.gov (United States)

St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

2016-01-01

We explore the conditions under which short, comparative interrupted time-series (CITS) designs represent valid alternatives to randomized experiments in educational evaluations. To do so, we conduct three within-study comparisons, each of which uses a unique data set to test the validity of the CITS design by comparing its causal estimates to…

Design Study for the Asteroid Redirect Vehicle (ARV) Composite Primary Bulkhead

Science.gov (United States)

Cressman, Thomas O.; Paddock, David A.

2017-01-01

A design study was undertaken of a carbon fiber primary bulkhead for a large solar electric propulsion (SEP) spacecraft. The bulkhead design, supporting up to 16 t of xenon propellant, progressed from one consisting of many simple parts with many complex joints, to one consisting of a few complex parts with a few simple joints. The unique capabilities of composites led to a topology that transitioned loads from bending to in-plane tension and shear, with low part count. This significantly improved bulkhead manufacturability, cost, and mass. The stiffness-driven structure utilized high-modulus M55J fiber unidirectional prepregs. A full-scale engineering demonstration unit (EDU) of the concept was used to demonstrate manufacturability of the concept. Actual labor data was obtained, which could be extrapolated to a full bulkhead. The effort demonstrated the practicality of using high-modulus fiber (HMF) composites for unique shape topologies that minimize mass and cost. The lessons are applicable to primary and secondary aerospace structures that are stiffness driven.

The liberal illusion of uniqueness.

Science.gov (United States)

Stern, Chadly; West, Tessa V; Schmitt, Peter G

2014-01-01

In two studies, we demonstrated that liberals underestimate their similarity to other liberals (i.e., display truly false uniqueness), whereas moderates and conservatives overestimate their similarity to other moderates and conservatives (i.e., display truly false consensus; Studies 1 and 2). We further demonstrated that a fundamental difference between liberals and conservatives in the motivation to feel unique explains this ideological distinction in the accuracy of estimating similarity (Study 2). Implications of the accuracy of consensus estimates for mobilizing liberal and conservative political movements are discussed.

Unique features of space reactors

International Nuclear Information System (INIS)

Buden, D.

1990-01-01

This paper reports on space reactors that are designed to meet a unique set of requirements; they must be sufficiently compact to be launched in a rocket to their operational location, operate for many years without maintenance and servicing, operate in extreme environments, and reject heat by radiation to space. To meet these restrictions, operating temperatures are much greater than in terrestrial power plants, and the reactors tend to have a fast neutron spectrum. Currently, a new generation of space reactor power plants is being developed. The major effort is in the SP-100 program, where the power plant is being designed for seven years of full power, and no maintenance operation at a reactor outlet operating temperature of 1350 K

RUCS: Rapid identification of PCR primers for unique core sequences

DEFF Research Database (Denmark)

Thomsen, Martin Christen Frølund; Hasman, Henrik; Westh, Henrik

2017-01-01

Designing PCR primers to target a specific selection of whole genome sequenced strains can be a long, arduous, and sometimes impractical task. Such tasks would benefit greatly from an automated tool to both identify unique targets, and to validate the vast number of potential primer pairs...... for the targets in silico . Here we present RUCS, a program that will find PCR primer pairs and probes for the unique core sequences of a positive genome dataset complement to a negative genome dataset. The resulting primer pairs and probes are in addition to simple selection also validated through a complex...... in silico PCR simulation. We compared our method, which identifies the unique core sequences, against an existing tool called ssGeneFinder, and found that our method was 6.5-20 times more sensitive. We used RUCS to design primer pairs that would target a set of genomes known to contain the mcr-1 colistin...

A Propagative Model of Simultaneous Impact: Existence, Uniqueness, and Design Consequences

OpenAIRE

Seghete, Vlad; Murphey, Todd

2017-01-01

This paper presents existence and uniqueness results for a propagative model of simultaneous impacts that is guaranteed to conserve energy and momentum in the case of elastic impacts with extensions to perfectly plastic and inelastic impacts. A corresponding time-stepping algorithm that guarantees conservation of continuous energy and discrete momentum is developed, also with extensions to plastic and inelastic impacts. The model is illustrated in simulation using billiard balls and a two-dim...

A Unique Capsule Locus in the Newly Designated Actinobacillus pleuropneumoniae Serovar 16 and Development of a Diagnostic PCR Assay.

Science.gov (United States)

Bossé, Janine T; Li, Yanwen; Sárközi, Rita; Gottschalk, Marcelo; Angen, Øystein; Nedbalcova, Katerina; Rycroft, Andrew N; Fodor, László; Langford, Paul R

2017-03-01

Actinobacillus pleuropneumoniae causes pleuropneumonia, an economically significant lung disease of pigs. Recently, isolates of A. pleuropneumoniae that were serologically distinct from the previously characterized 15 serovars were described, and a proposal was put forward that they comprised a new serovar, serovar 16. Here we used whole-genome sequencing of the proposed serovar 16 reference strain A-85/14 to confirm the presence of a unique capsular polysaccharide biosynthetic locus. For molecular diagnostics, primers were designed from the capsule locus of strain A-85/14, and a PCR was formulated that differentiated serovar 16 isolates from all 15 known serovars and other common respiratory pathogenic/commensal bacteria of pigs. Analysis of the capsule locus of strain A-85/14 combined with the previous serological data show the existence of a sixteenth serovar-designated serovar 16-of A. pleuropneumoniae . Copyright © 2017 Bossé et al.

Computational topology and the Unique Games Conjecture

OpenAIRE

Grochow, Joshua A.; Tucker-Foltz, Jamie

2018-01-01

Covering spaces of graphs have long been useful for studying expanders (as "graph lifts") and unique games (as the "label-extended graph"). In this paper we advocate for the thesis that there is a much deeper relationship between computational topology and the Unique Games Conjecture. Our starting point is Linial's 2005 observation that the only known problems whose inapproximability is equivalent to the Unique Games Conjecture - Unique Games and Max-2Lin - are instances of Maximum Section of...

SCC500: next-generation infrared imaging camera core products with highly flexible architecture for unique camera designs

Science.gov (United States)

Rumbaugh, Roy N.; Grealish, Kevin; Kacir, Tom; Arsenault, Barry; Murphy, Robert H.; Miller, Scott

2003-09-01

A new 4th generation MicroIR architecture is introduced as the latest in the highly successful Standard Camera Core (SCC) series by BAE SYSTEMS to offer an infrared imaging engine with greatly reduced size, weight, power, and cost. The advanced SCC500 architecture provides great flexibility in configuration to include multiple resolutions, an industry standard Real Time Operating System (RTOS) for customer specific software application plug-ins, and a highly modular construction for unique physical and interface options. These microbolometer based camera cores offer outstanding and reliable performance over an extended operating temperature range to meet the demanding requirements of real-world environments. A highly integrated lens and shutter is included in the new SCC500 product enabling easy, drop-in camera designs for quick time-to-market product introductions.

Lip prints- A study of its uniqueness among students of MediCiti Medical College.

Science.gov (United States)

Alzapur, Archana; Nagothu, Rajani S; Nalluri, Hima B

2017-01-01

"Cheiloscopy" is a technique that deals with lip prints. The pattern of fine creases on the lips are unique to the individual. They are similar to finger prints and useful in crime investigation. To study the uniqueness, prevalence, and gender significance of lip print patterns in human subjects. The study was conducted on 100 randomly selected male and female undergraduate medical students. The lip print of each subject was obtained and its pattern was analyzed according to Suzuki and Tsuchihashi classification. The study showed that Type I lip pattern was the commonest. Our study has added to confirmation of the distinctiveness of cheiloscopy, which can be used as an additional tool for identification. Studies on lip prints being very scanty, our findings add significantly to the meager literature on this subject. Further in-depth studies to establish prevalence of patterns in lip prints will certainly help as useful evidence in forensic investigations.

Unique associations among emotion dysregulation dimensions and aggressive tendencies : A multi-site study

NARCIS (Netherlands)

Velotti, Patrizia; Casselman, Robert B.; Garofalo, C.; McKenzie, Melissa D.

2017-01-01

While problems with emotion regulation (ER) have long been associated with internalizing symptoms, only recently has an ER framework been applied to the study of aggression. Therefore, little is known about the unique and independent associations between specific domains of the ER construct and

Modularity, comparative cognition and human uniqueness.

Science.gov (United States)

Shettleworth, Sara J

2012-10-05

Darwin's claim 'that the difference in mind between man and the higher animals … is certainly one of degree and not of kind' is at the core of the comparative study of cognition. Recent research provides unprecedented support for Darwin's claim as well as new reasons to question it, stimulating new theories of human cognitive uniqueness. This article compares and evaluates approaches to such theories. Some prominent theories propose sweeping domain-general characterizations of the difference in cognitive capabilities and/or mechanisms between adult humans and other animals. Dual-process theories for some cognitive domains propose that adult human cognition shares simple basic processes with that of other animals while additionally including slower-developing and more explicit uniquely human processes. These theories are consistent with a modular account of cognition and the 'core knowledge' account of children's cognitive development. A complementary proposal is that human infants have unique social and/or cognitive adaptations for uniquely human learning. A view of human cognitive architecture as a mosaic of unique and species-general modular and domain-general processes together with a focus on uniquely human developmental mechanisms is consistent with modern evolutionary-developmental biology and suggests new questions for comparative research.

Social marketing's unique contribution to mental health stigma reduction and HIV testing: two case studies.

Science.gov (United States)

Thackeray, Rosemary; Keller, Heidi; Heilbronner, Jennifer Messenger; Dellinger, Laura K Lee

2011-03-01

Since its inception in 2005, articles in Health Promotion Practice's social marketing department have focused on describing social marketing's unique contributions and the application of each to the practice of health promotion. This article provides a brief review of six unique features (marketing mix, consumer orientation, segmentation, exchange, competition, and continuous monitoring) and then presents two case studies-one on reducing stigma related to mental health and the other a large-scale campaign focused on increasing HIV testing among African American youth. The two successful case studies show that social marketing principles can be applied to a wide variety of topics among various population groups.

Sense of Community in a Blended Technology Integration Course: A Design-Based Research Study

Science.gov (United States)

Harrison, J. Buckley; West, Richard E.

2014-01-01

This design-based research study explored whether "sense of community" was maintained while flexibility in the course was increased through an adoption of a unique blended learning model. Data collected in this study show a significant drop in the sense of connectedness score from a mean of 50.8 out of 66 to a mean of 39.68 in the first…

The Svalbard study 1988-89: a unique setting for validation of self-reported alcohol consumption.

Science.gov (United States)

Høyer, G; Nilssen, O; Brenn, T; Schirmer, H

1995-04-01

The Norwegian island of Spitzbergen, Svalbard offers a unique setting for validation studies on self-reported alcohol consumption. No counterfeit production or illegal import exists, thus making complete registration of all sources of alcohol possible. In this study we recorded sales from all agencies selling alcohol on Svalbard over a 2-month period in 1988. During the same period all adults living permanently on Svalbard were invited to take part in a health screening. As part of the screening a self-administered questionnaire on alcohol consumption was introduced to the participants. We found that the self-reported volume accounted for approximately 40 percent of the sales volume. Because of the unique situation applying to Svalbard, the estimate made in this study is believed to be more reliable compared to other studies using sales volume to validate self-reports.

Identification of Unique Metabolites of the Designer Opioid Furanyl Fentanyl.

Science.gov (United States)

Goggin, Melissa M; Nguyen, An; Janis, Gregory C

2017-06-01

The illicit drug market has seen an increase in designer opioids, including fentanyl and methadone analogs, and other structurally unrelated opioid agonists. The designer opioid, furanyl fentanyl, is one of many fentanyl analogs clandestinely synthesized for recreational use and contributing to the fentanyl and opioid crisis. A method has been developed and validated for the analysis of furanyl fentanyl and furanyl norfentanyl in urine specimens from pain management programs. Approximately 10% of samples from a set of 500 presumptive heroin-positive urine specimens were found to contain furanyl fentanyl, with an average concentration of 33.8 ng/mL, and ranging from 0.26 to 390 ng/mL. Little to no furanyl norfentanyl was observed; therefore, the furanyl fentanyl specimens were further analyzed by untargeted high-resolution mass spectrometry to identify other metabolites. Multiple metabolites, including a dihydrodiol metabolite, 4-anilino-N-phenethyl-piperidine (4-ANPP) and a sulfate metabolite were identified. The aim of the presented study was to identify the major metabolite(s) of furanyl fentanyl and estimate their concentrations for the purpose of toxicological monitoring. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

The Unique Optical Design of the CTI-II Survey Telescope

Science.gov (United States)

Ackermann, Mark R.; McGraw, J. T.; MacFarlane, M.

2006-12-01

The CCD/Transit Instrument with Innovative Instrumentation (CTI-II) is being developed for precision ground-based astrometric and photometric astronomical observations. The 1.8m telescope will be stationary, near-zenith pointing and will feature a CCD-mosaic array operated in time-delay and integrate (TDI) mode to image a continuous strip of the sky in five bands. The heart of the telescope is a Nasmyth-like bent-Cassegrain optical system optimized to produce near diffraction-limited images with near zero distortion over a circular1.42 deg field. The optical design includes an f/2.2 parabolic ULE primary with no central hole salvaged from the original CTI telescope and adds the requisite hyperbolic secondary, a folding flat and a highly innovative all-spherical, five lens corrector which includes three plano surfaces. The reflective and refractive portions of the design have been optimized as individual but interdependent systems so that the same reflective system can be used with slightly different refractive correctors. At present, two nearly identical corrector designs are being evaluated, one fabricated from BK-7 glass and the other of fused silica. The five lens corrector consists of an air-spaced triplet separated from follow-on air-spaced doublet. Either design produces 0.25 arcsecond images at 83% encircled energy with a maximum of 0.0005% distortion. The innovative five lens corrector design has been applied to other current and planned Cassegrain, RC and super RC optical systems requiring correctors. The basic five lens approach always results in improved performance compared to the original designs. In some cases, the improvement in image quality is small but includes substantial reductions in distortion. In other cases, the improvement in image quality is substantial. Because the CTI-II corrector is designed for a parabolic primary, it might be especially useful for liquid mirror telescopes. We describe and discuss the CTI-II optical design with respect

Uniqueness and non-uniqueness of semigroups generated by singular diffusion operators

CERN Document Server

Eberle, Andreas

1999-01-01

This book addresses both probabilists working on diffusion processes and analysts interested in linear parabolic partial differential equations with singular coefficients. The central question discussed is whether a given diffusion operator, i.e., a second order linear differential operator without zeroth order term, which is a priori defined on test functions over some (finite or infinite dimensional) state space only, uniquely determines a strongly continuous semigroup on a corresponding weighted Lp space. Particular emphasis is placed on phenomena causing non-uniqueness, as well as on the relation between different notions of uniqueness appearing in analytic and probabilistic contexts.

Architectural analysis and intraoperative measurements demonstrate the unique design of the multifidus muscle for lumbar spine stability.

Science.gov (United States)

Ward, Samuel R; Kim, Choll W; Eng, Carolyn M; Gottschalk, Lionel J; Tomiya, Akihito; Garfin, Steven R; Lieber, Richard L

2009-01-01

Muscular instability is an important risk factor for lumbar spine injury and chronic low-back pain. Although the lumbar multifidus muscle is considered an important paraspinal muscle, its design features are not completely understood. The purpose of the present study was to determine the architectural properties, in vivo sarcomere length operating range, and passive mechanical properties of the human multifidus muscle. We hypothesized that its architecture would be characterized by short fibers and a large physiological cross-sectional area and that it would operate over a relatively wide range of sarcomere lengths but would have very stiff passive material properties. The lumbar spines of eight cadaver specimens were excised en bloc from T12 to the sacrum. Multifidus muscles were isolated from each vertebral level, permitting the architectural measurements of mass, sarcomere length, normalized fiber length, physiological cross-sectional area, and fiber length-to-muscle length ratio. To determine the sarcomere length operating range of the muscle, sarcomere lengths were measured from intraoperative biopsy specimens that were obtained with the spine in the flexed and extended positions. The material properties of single muscle fibers were obtained from passive stress-strain tests of excised biopsy specimens. The average muscle mass (and standard error) was 146 +/- 8.7 g, and the average sarcomere length was 2.27 +/- 0.06 microm, yielding an average normalized fiber length of 5.66 +/- 0.65 cm, an average physiological cross-sectional area of 23.9 +/- 3.0 cm(2), and an average fiber length-to-muscle length ratio of 0.21 +/- 0.03. Intraoperative sarcomere length measurements revealed that the muscle operates from 1.98 +/- 0.15 microm in extension to 2.70 +/- 0.11 microm in flexion. Passive mechanical data suggested that the material properties of the muscle are comparable with those of muscles of the arm or leg. The architectural design (a high cross-sectional area and

IPAD: A unique approach to government/industry cooperation for technology development and transfer

Science.gov (United States)

Fulton, Robert E.; Salley, George C.

1985-01-01

A key element to improved industry productivity is effective management of Computer Aided Design / Computer Aided Manufacturing (CAD/CAM) information. To stimulate advancement, a unique joint government/industry project designated Integrated Programs for Aerospace-Vehicle Design (IPAD) was carried out from 1971 to 1984. The goal was to raise aerospace industry productivity through advancement of computer based technology to integrate and manage information involved in the design and manufacturing process. IPAD research was guided by an Industry Technical Advisory Board (ITAB) composed of over 100 representatives from aerospace and computer companies. The project complemented traditional NASA/DOD research to develop aerospace design technology and the Air Force's Integrated Computer Aided Manufacturing (ICAM) program to advance CAM technology. IPAD had unprecedented industry support and involvement and served as a unique approach to government industry cooperation in the development and transfer of advanced technology. The IPAD project background, approach, accomplishments, industry involvement, technology transfer mechanisms and lessons learned are summarized.

A unique nuclear thermal rocket engine using a particle bed reactor

Science.gov (United States)

Culver, Donald W.; Dahl, Wayne B.; McIlwain, Melvin C.

1992-01-01

Aerojet Propulsion Division (APD) studied 75-klb thrust Nuclear Thermal Rocket Engines (NTRE) with particle bed reactors (PBR) for application to NASA's manned Mars mission and prepared a conceptual design description of a unique engine that best satisfied mission-defined propulsion requirements and customer criteria. This paper describes the selection of a sprint-type Mars transfer mission and its impact on propulsion system design and operation. It shows how our NTRE concept was developed from this information. The resulting, unusual engine design is short, lightweight, and capable of high specific impulse operation, all factors that decrease Earth to orbit launch costs. Many unusual features of the NTRE are discussed, including nozzle area ratio variation and nozzle closure for closed loop after cooling. Mission performance calculations reveal that other well known engine options do not support this mission.

Addressing Unison and Uniqueness of Reliability and Safety for Better Integration

Science.gov (United States)

Huang, Zhaofeng; Safie, Fayssal

2015-01-01

For a long time, both in theory and in practice, safety and reliability have not been clearly differentiated, which leads to confusion, inefficiency, and sometime counter-productive practices in executing each of these two disciplines. It is imperative to address the uniqueness and the unison of these two disciplines to help both disciplines become more effective and to promote a better integration of the two for enhancing safety and reliability in our products as an overall objective. There are two purposes of this paper. First, it will investigate the uniqueness and unison of each discipline and discuss the interrelationship between the two for awareness and clarification. Second, after clearly understanding the unique roles and interrelationship between the two in a product design and development life cycle, we offer suggestions to enhance the disciplines with distinguished and focused roles, to better integrate the two, and to improve unique sets of skills and tools of reliability and safety processes. From the uniqueness aspect, the paper identifies and discusses the respective uniqueness of reliability and safety from their roles, accountability, nature of requirements, technical scopes, detailed technical approaches, and analysis boundaries. It is misleading to equate unreliable to unsafe, since a safety hazard may or may not be related to the component, sub-system, or system functions, which are primarily what reliability addresses. Similarly, failing-to-function may or may not lead to hazard events. Examples will be given in the paper from aerospace, defense, and consumer products to illustrate the uniqueness and differences between reliability and safety. From the unison aspect, the paper discusses what the commonalities between reliability and safety are, and how these two disciplines are linked, integrated, and supplemented with each other to accomplish the customer requirements and product goals. In addition to understanding the uniqueness in

Move the Neighborhood: study design of a community-based participatory public open space intervention

DEFF Research Database (Denmark)

Pawlowski, Charlotte Skau; Winge, Laura; Carroll, Sidse

evaluation will be used to gain knowledge of the intervention processes. DISCUSSION: The study presents new methods and approaches in the field of public open space interventions through interdisciplinary collaboration, participatory co-design approach and combination of measurements. Using both effect......BACKGROUND: A limited amount of research has examined the effect of changing public open spaces on active living. This abstract presents the study protocol of an intervention study designed in an interdisciplinary collaboration built on principles of Community-Based Participatory Research (CBPR...... and process evaluations the study will provide unique insights in the role and importance of the interdisciplinary collaboration, participatory processes, tailoring changes in public open space to local needs and wishes. These results can be used to guide urban renewal projects in deprived neighbourhoods...

The MSFC Collaborative Engineering Process for Preliminary Design and Concept Definition Studies

Science.gov (United States)

Mulqueen, Jack; Jones, David; Hopkins, Randy

2011-01-01

This paper describes a collaborative engineering process developed by the Marshall Space Flight Center's Advanced Concepts Office for performing rapid preliminary design and mission concept definition studies for potential future NASA missions. The process has been developed and demonstrated for a broad range of mission studies including human space exploration missions, space transportation system studies and in-space science missions. The paper will describe the design team structure and specialized analytical tools that have been developed to enable a unique rapid design process. The collaborative engineering process consists of integrated analysis approach for mission definition, vehicle definition and system engineering. The relevance of the collaborative process elements to the standard NASA NPR 7120.1 system engineering process will be demonstrated. The study definition process flow for each study discipline will be will be outlined beginning with the study planning process, followed by definition of ground rules and assumptions, definition of study trades, mission analysis and subsystem analyses leading to a standardized set of mission concept study products. The flexibility of the collaborative engineering design process to accommodate a wide range of study objectives from technology definition and requirements definition to preliminary design studies will be addressed. The paper will also describe the applicability of the collaborative engineering process to include an integrated systems analysis approach for evaluating the functional requirements of evolving system technologies and capabilities needed to meet the needs of future NASA programs.

Tattoos and piercings: bodily expressions of uniqueness?

Science.gov (United States)

Tiggemann, Marika; Hopkins, Louise A

2011-06-01

The study aimed to investigate the motivations underlying the body modification practices of tattooing and piercing. There were 80 participants recruited from an Australian music store, who provided descriptions of their tattoos and piercings and completed measures of need for uniqueness, appearance investment and distinctive appearance investment. It was found that tattooed individuals scored significantly higher on need for uniqueness than non-tattooed individuals. Further, individuals with conventional ear piercings scored significantly lower on need for uniqueness than individuals with no piercings or with facial and body piercings. Neither appearance investment nor distinctive appearance investment differed significantly among tattoo or piercing status groups. Strength of identification with music was significantly correlated with number of tattoos, but not number of piercings. It was concluded that tattooing, but not body piercing, represents a bodily expression of uniqueness. Copyright © 2011 Elsevier Ltd. All rights reserved.

The Munich MIDY Pig Biobank – A unique resource for studying organ crosstalk in diabetes

Directory of Open Access Journals (Sweden)

Andreas Blutke

2017-08-01

Conclusions: The broad spectrum of well-defined biosamples in the Munich MIDY Pig Biobank that will be available to the scientific community provides a unique resource for systematic studies of organ crosstalk in diabetes in a multi-organ, multi-omics dimension.

Customization: Ideal Varieties, Product Uniqueness and Price Competition

OpenAIRE

Oksana Loginova; X. Henry Wang

2009-01-01

We study customization in the Hotelling model with two firms. In addition to providing ideal varieties, the perceived uniqueness of a customized product contributes independently to consumer utility. We show that only when consumer preferences for uniqueness are high customization occurs in equilibrium.

New roller cone bits with unique nozzle designs reduce drilling costs

International Nuclear Information System (INIS)

Moffitt, S.R.; Pearce, D.E.; Ivie, C.R.

1992-01-01

This paper reports that selection of the optimum rock bit design to achieve the lowest drilling cost in a given application is often difficult due to a large number of rock bit performance considerations. However, in a majority of applications increased penetration rate is the key consideration in reducing drilling costs. Discovery of a new bit design concept has led to the development of roller cone bits that achieve significant penetration rate increases using superior hydraulic nozzle designs. Prototype designs have achieved 20 to 40% increases in penetration rate with comparable footage drilled when tested in 6 1/2, 8 1/2, 8-3/4, 9-7/8 and 12 1/4 IADC 437, 517 and 537 type bits in the U.S., North Sea, Italy, and Oman. Second-generation designs tested in a full-scale drilling laboratory have delivered 70% increases in penetration rates

Uniquely Strongly Clean Group Rings

Institute of Scientific and Technical Information of China (English)

WANG XIU-LAN

2012-01-01

A ring R is called clean if every element is the sum of an idempotent and a unit,and R is called uniquely strongly clean (USC for short) if every element is uniquely the sum of an idempotent and a unit that commute.In this article,some conditions on a ring R and a group G such that RG is clean are given.It is also shown that if G is a locally finite group,then the group ring RG is USC if and only if R is USC,and G is a 2-group.The left uniquely exchange group ring,as a middle ring of the uniquely clean ring and the USC ring,does not possess this property,and so does the uniquely exchange group ring.

Optimum study designs.

Science.gov (United States)

Gu, C; Rao, D C

2001-01-01

Because simplistic designs will lead to prohibitively large sample sizes, the optimization of genetic study designs is critical for successfully mapping genes for complex diseases. Creative designs are necessary for detecting and amplifying the usually weak signals for complex traits. Two important outcomes of a study design--power and resolution--are implicitly tied together by the principle of uncertainty. Overemphasis on either one may lead to suboptimal designs. To achieve optimality for a particular study, therefore, practical measures such as cost-effectiveness must be used to strike a balance between power and resolution. In this light, the myriad of factors involved in study design can be checked for their effects on the ultimate outcomes, and the popular existing designs can be sorted into building blocks that may be useful for particular situations. It is hoped that imaginative construction of novel designs using such building blocks will lead to enhanced efficiency in finding genes for complex human traits.

The Glory Program: Global Science from a Unique Spacecraft Integration

Science.gov (United States)

Bajpayee Jaya; Durham, Darcie; Ichkawich, Thomas

2006-01-01

The Glory program is an Earth and Solar science mission designed to broaden science community knowledge of the environment. The causes and effects of global warming have become a concern in recent years and Glory aims to contribute to the knowledge base of the science community. Glory is designed for two functions: one is solar viewing to monitor the total solar irradiance and the other is observing the Earth s atmosphere for aerosol composition. The former is done with an active cavity radiometer, while the latter is accomplished with an aerosol polarimeter sensor to discern atmospheric particles. The Glory program is managed by NASA Goddard Space Flight Center (GSFC) with Orbital Sciences in Dulles, VA as the prime contractor for the spacecraft bus, mission operations, and ground system. This paper will describe some of the more unique features of the Glory program including the integration and testing of the satellite and instruments as well as the science data processing. The spacecraft integration and test approach requires extensive analysis and additional planning to ensure existing components are successfully functioning with the new Glory components. The science mission data analysis requires development of mission unique processing systems and algorithms. Science data analysis and distribution will utilize our national assets at the Goddard Institute for Space Studies (GISS) and the University of Colorado's Laboratory for Atmospheric and Space Physics (LASP). The Satellite was originally designed and built for the Vegetation Canopy Lidar (VCL) mission, which was terminated in the middle of integration and testing due to payload development issues. The bus was then placed in secure storage in 2001 and removed from an environmentally controlled container in late 2003 to be refurbished to meet the Glory program requirements. Functional testing of all the components was done as a system at the start of the program, very different from a traditional program

CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics.

Directory of Open Access Journals (Sweden)

Andreas Schweizer

2008-07-01

Full Text Available Here, we describe the generation of a novel type of HIV entry inhibitor using the recently developed Designed Ankyrin Repeat Protein (DARPin technology. DARPin proteins specific for human CD4 were selected from a DARPin DNA library using ribosome display. Selected pool members interacted specifically with CD4 and competed with gp120 for binding to CD4. DARPin proteins derived in the initial selection series inhibited HIV in a dose-dependent manner, but showed a relatively high variability in their capacity to block replication of patient isolates on primary CD4 T cells. In consequence, a second series of CD4-specific DARPins with improved affinity for CD4 was generated. These 2nd series DARPins potently inhibit infection of genetically divergent (subtype B and C HIV isolates in the low nanomolar range, independent of coreceptor usage. Importantly, the actions of the CD4 binding DARPins were highly specific: no effect on cell viability or activation, CD4 memory cell function, or interference with CD4-independent virus entry was observed. These novel CD4 targeting molecules described here combine the unique characteristics of DARPins-high physical stability, specificity and low production costs-with the capacity to potently block HIV entry, rendering them promising candidates for microbicide development.

Wind turbine generator application places unique demands on tower design and materials

Science.gov (United States)

Kita, J. P.

1978-01-01

The most relevant contractual tower design requirements and goal for the Mod-1 tower are related to steel truss tower construction, cost-effective state-of-the-art design, a design life of 30 years, and maximum wind conditions of 120 mph at 30 feet elevation. The Mod-1 tower design approach was an iterative process. Static design loads were calculated and member sizes and overall geometry chosen with the use of finite element computer techniques. Initial tower dynamic characteristics were then combined with the dynamic properties of the other wind turbine components, and a series of complex dynamic computer programs were run to establish a dynamic load set and then a second tower design.

Upper gastrointestinal bleeding caused by severe esophagitis: a unique clinical syndrome.

Science.gov (United States)

Guntipalli, Prathima; Chason, Rebecca; Elliott, Alan; Rockey, Don C

2014-12-01

We have recognized a unique clinical syndrome in patients with upper gastrointestinal bleeding who are found to have severe esophagitis. We aimed to more clearly describe the clinical entity of upper gastrointestinal bleeding in patients with severe esophagitis. We conducted a retrospective matched case-control study designed to investigate clinical features in patients with carefully defined upper gastrointestinal bleeding and severe esophagitis. Patient data were captured prospectively via a Gastrointestinal Bleeding Healthcare Registry, which collects data on all patients admitted with gastrointestinal bleeding. Patients with endoscopically documented esophagitis (cases) were matched with randomly selected controls that had upper gastrointestinal bleeding caused by other lesions. Epidemiologic features in patients with esophagitis were similar to those with other causes of upper gastrointestinal bleeding. However, hematemesis was more common in patients with esophagitis 86% (102/119) than in controls 55% (196/357) (p bleeding than those without cirrhosis. We have described a unique clinical syndrome in patients with upper gastrointestinal bleeding who have erosive esophagitis. This syndrome is manifest by typical clinical features and is associated with favorable outcomes.

A novel edge based embedding in medical images based on unique key generated using sudoku puzzle design.

Science.gov (United States)

Santhi, B; Dheeptha, B

2016-01-01

The field of telemedicine has gained immense momentum, owing to the need for transmitting patients' information securely. This paper puts forth a unique method for embedding data in medical images. It is based on edge based embedding and XOR coding. The algorithm proposes a novel key generation technique by utilizing the design of a sudoku puzzle to enhance the security of the transmitted message. The edge blocks of the cover image alone, are utilized to embed the payloads. The least significant bit of the pixel values are changed by XOR coding depending on the data to be embedded and the key generated. Hence the distortion in the stego image is minimized and the information is retrieved accurately. Data is embedded in the RGB planes of the cover image, thus increasing its embedding capacity. Several measures including peak signal noise ratio (PSNR), mean square error (MSE), universal image quality index (UIQI) and correlation coefficient (R) are the image quality measures that have been used to analyze the quality of the stego image. It is evident from the results that the proposed technique outperforms the former methodologies.

Ultrasound comparison of external and internal neck anatomy with the LMA Unique

Directory of Open Access Journals (Sweden)

Steven M. Lee

2017-12-01

Full Text Available Introduction: Internal neck anatomy landmarks and their relation after placement of an extraglottic airway devices have not been studied extensively by the use of ultrasound. Based on our group experience with external landmarks as well as internal landmarks evaluation with other techniques, we aimed use ultrasound to analyze the internal neck anatomy landmarks and the related changes due to the placement of the Laryngeal Mask Airway Unique. Methods: Observational pilot investigation. Non-obese adult patients with no evidence of airway anomalies, were recruited. External neck landmarks were measured based on a validated and standardized method by tape. Eight internal anatomical landmarks, reciprocal by the investigational hypothesis to the external landmarks, were also measured by ultrasound guidance. The internal landmarks were re-measured after optimal placement and inflation of the extraglottic airway devices cuff Laryngeal Mask Airway Unique. Results: Six subjects were recruited. Ultrasound measurements of hyoid-mental distance, thyroid-cricoid distance, thyroid height, and thyroid width were found to be significantly (p < 0.05 overestimated using a tape measure. Sagittal neck landmark distances such as thyroid height, sternal-mental distance, and thyroid-cricoid distance significantly decreased after placement of the Laryngeal Mask Airway Unique. Conclusion: The laryngeal mask airway Unique resulted in significant changes in internal neck anatomy. The induced changes and respective specific internal neck anatomy landmarks could help to design devices that would modify their shape accordingly to areas of greatest displacement. Also, while external neck landmark measurements overestimate their respective internal neck landmarks, as we previously reported, the concordance of each measurement and their respective conversion factor could continue to be of help in sizing extraglottic airway devices. Due to the pilot nature of the study, more

Full‐factorial design space exploration approach for multi‐criteria decision making of the design of industrial halls

NARCIS (Netherlands)

Lee, B. (Bruno); Pourmousavian, N. (Navid); Hensen, J.L.M.

2016-01-01

Industrial halls pose high energy saving potential that is not yet explored under current design practice. Common design approaches such as parametric study or optimization are largely constrained by the assumptions and do not promote flexibility in the decision making process. Based on the unique

Fluorescent Photo-conversion: A second chance to label unique cells.

Science.gov (United States)

Mellott, Adam J; Shinogle, Heather E; Moore, David S; Detamore, Michael S

2015-03-01

Not all cells behave uniformly after treatment in tissue engineering studies. In fact, some treated cells display no signs of treatment or show unique characteristics not consistent with other treated cells. What if the "unique" cells could be isolated from a treated population, and further studied? Photo-convertible reporter proteins, such as Dendra2 , allow for the ability to selectively identify unique cells with a secondary label within a primary labeled treated population. In the current study, select cells were identified and labeled through photo-conversion of Dendra2 -transfected human Wharton's Jelly cells (hWJCs) for the first time. Robust photo-conversion of green-to-red fluorescence was achieved consistently in arbitrarily selected cells, allowing for precise cell identification of select hWJCs. The current study demonstrates a method that offers investigators the opportunity to selectively label and identify unique cells within a treated population for further study or isolation from the treatment population. Photo-convertible reporter proteins, such as Dendra2 , offer the ability over non-photo-convertible reporter proteins, such as green fluorescent protein, to analyze unique individual cells within a treated population, which allows investigators to gain more meaningful information on how a treatment affects all cells within a target population.

Compact reversed-field pinch reactors (CRFPR): sensitivity study and design-point determination

International Nuclear Information System (INIS)

Hagenson, R.L.; Krakowski, R.A.

1982-07-01

If the costing assumptions upon which the positive assessment of conventional large superconducting fusion reactors are based proves overly optimistic, approaches that promise considerably increased system power density and reduced mass utilization will be required. These more compact reactor embodiments generally must operate with reduced shield thickness and resistive magnets. Because of the unique, magnetic topology associated with the Reversed-Field Pinch (RFP), the compact reactor embodiment for this approach is particularly attractive from the viewpoint of low-field resistive coils operating with Ohmic losses that can be made small relative to the fusion power. A comprehensive system model is developed and described for a steady-state, compact RFP reactor (CRFPR). This model is used to select a unique cost-optimized design point that will be used for a conceptual engineering design. The cost-optimized CRFPR design presented herein would operate with system power densities and mass utilizations that are comparable to fission power plants and are an order of magnitude more favorable than the conventional approaches to magnetic fusion power. The sensitivity of the base-case design point to changes in plasma transport, profiles, beta, blanket thickness, normal vs superconducting coils, and fuel cycle (DT vs DD) is examined. The RFP approach is found to yield a point design for a high-power-density reactor that is surprisingly resilient to changes in key, but relatively unknown, physics and systems parameters

The 4A Metric Algorithm: A Unique E-Learning Engineering Solution Designed via Neuroscience to Counter Cheating and Reduce Its Recidivism by Measuring Student Growth through Systemic Sequential Online Learning

Science.gov (United States)

Osler, James Edward

2016-01-01

This paper provides a novel instructional methodology that is a unique E-Learning engineered "4A Metric Algorithm" designed to conceptually address the four main challenges faced by 21st century students, who are tempted to cheat in a myriad of higher education settings (face to face, hybrid, and online). The algorithmic online…

Taking Engineering Design out for a Spin

Science.gov (United States)

Crismond, David; Soobyiah, Mark; Cain, Ryan

2013-01-01

This article highlights what inquiry and design have in common, and what makes engineering design uniquely different from inquiry. A case study is presented that gives students practice in conducting fair-test experiments, in troubleshooting to learn how to make designs better, and in building science-based explanations for how things work. The…

NHash: Randomized N-Gram Hashing for Distributed Generation of Validatable Unique Study Identifiers in Multicenter Research.

Science.gov (United States)

Zhang, Guo-Qiang; Tao, Shiqiang; Xing, Guangming; Mozes, Jeno; Zonjy, Bilal; Lhatoo, Samden D; Cui, Licong

2015-11-10

A unique study identifier serves as a key for linking research data about a study subject without revealing protected health information in the identifier. While sufficient for single-site and limited-scale studies, the use of common unique study identifiers has several drawbacks for large multicenter studies, where thousands of research participants may be recruited from multiple sites. An important property of study identifiers is error tolerance (or validatable), in that inadvertent editing mistakes during their transmission and use will most likely result in invalid study identifiers. This paper introduces a novel method called "Randomized N-gram Hashing (NHash)," for generating unique study identifiers in a distributed and validatable fashion, in multicenter research. NHash has a unique set of properties: (1) it is a pseudonym serving the purpose of linking research data about a study participant for research purposes; (2) it can be generated automatically in a completely distributed fashion with virtually no risk for identifier collision; (3) it incorporates a set of cryptographic hash functions based on N-grams, with a combination of additional encryption techniques such as a shift cipher; (d) it is validatable (error tolerant) in the sense that inadvertent edit errors will mostly result in invalid identifiers. NHash consists of 2 phases. First, an intermediate string using randomized N-gram hashing is generated. This string consists of a collection of N-gram hashes f1, f2, ..., fk. The input for each function fi has 3 components: a random number r, an integer n, and input data m. The result, fi(r, n, m), is an n-gram of m with a starting position s, which is computed as (r mod |m|), where |m| represents the length of m. The output for Step 1 is the concatenation of the sequence f1(r1, n1, m1), f2(r2, n2, m2), ..., fk(rk, nk, mk). In the second phase, the intermediate string generated in Phase 1 is encrypted using techniques such as shift cipher. The result

Cancer: Unique to Older Adults

Science.gov (United States)

... A to Z › Cancer › Unique to Older Adults Font size A A A Print Share Glossary Unique ... group with other older people with the same type of cancer. Researchers have found that support groups ...

Design study of plastic film heat exchanger

Science.gov (United States)

Guyer, E. C.; Brownell, D. L.

1986-02-01

This report presents the results of an effort to develop and design a unique thermoplastic film heat exchanger for use in an industrial heat pump evaporator system and other energy recovery applications. The concept for the exchanger is that of individual heat exchange elements formed by two adjoining and freely hanging plastic films. Liquid flows downward in a regulated fashion between the films due to the balance of hydrostatic and frictional forces. The fluid stream on the outside of film may be a free-falling liquid film, a condensing gas, or a noncondensing gas. The flow and structural principles are similar to those embodied in an earlier heat exchange system developed for use in waste water treatment systems (Sanderson). The design allows for high heat transfer rates while working within the thermal and structural limitations of thermoplastic materials. The potential of this new heat exchanger design lies in the relatively low cost of plastic film and the high inherent corrosion and fouling resistance. This report addresses the selection of materials, the potential heat transf er performance, the mechanical design and operation of a unit applied in a low pressure steam recovery system, and the expected selling price in comparison to conventional metallic shell and tube heat exchangers.

The zenithal 4-m International Liquid Mirror Telescope: a unique facility for supernova studies

Science.gov (United States)

Kumar, Brajesh; Pandey, Kanhaiya L.; Pandey, S. B.; Hickson, P.; Borra, E. F.; Anupama, G. C.; Surdej, J.

2018-05-01

The 4-m International Liquid Mirror Telescope (ILMT) will soon become operational at the newly developed Devasthal observatory near Nainital (Uttarakhand, India). Coupled with a 4k × 4k pixels CCD detector and TDI optical corrector, it will reach approximately 22.8, 22.3, and 21.4 mag in the g΄, r΄, and i΄ spectral bands, respectively, in a single scan. The limiting magnitudes can be further improved by co-adding the consecutive night images in particular filters. The uniqueness to observe the same sky region by looking towards the zenith direction every night makes the ILMT a unique instrument to detect new supernovae (SNe) by applying the image subtraction technique. High cadence (˜24 h) observations will help to construct dense sampling multi-band SNe light curves. We discuss the importance of the ILMT facility in the context of SNe studies. Considering the various plausible cosmological parameters and observational constraints, we perform detailed calculations of the expected SNe rate that can be detected with the ILMT in different spectral bands.

Father involvement: Identifying and predicting family members' shared and unique perceptions.

Science.gov (United States)

Dyer, W Justin; Day, Randal D; Harper, James M

2014-08-01

Father involvement research has typically not recognized that reports of involvement contain at least two components: 1 reflecting a view of father involvement that is broadly recognized in the family, and another reflecting each reporter's unique perceptions. Using a longitudinal sample of 302 families, this study provides a first examination of shared and unique views of father involvement (engagement and warmth) from the perspectives of fathers, children, and mothers. This study also identifies influences on these shared and unique perspectives. Father involvement reports were obtained when the child was 12 and 14 years old. Mother reports overlapped more with the shared view than father or child reports. This suggests the mother's view may be more in line with broadly recognized father involvement. Regarding antecedents, for fathers' unique view, a compensatory model partially explains results; that is, negative aspects of family life were positively associated with fathers' unique view. Children's unique view of engagement may partially reflect a sentiment override with father antisocial behaviors being predictive. Mothers' unique view of engagement was predicted by father and mother work hours and her unique view of warmth was predicted by depression and maternal gatekeeping. Taken, together finding suggests a far more nuanced view of father involvement should be considered.

Lessons Learned from Applying Design Thinking in a NASA Rapid Design Study in Aeronautics

Science.gov (United States)

McGowan, Anna-Maria; Bakula, Casey; Castner, Raymond

2017-01-01

In late 2015, NASA's Aeronautics Research Mission Directorate (ARMD) funded an experiment in rapid design and rapid teaming to explore new approaches to solving challenging design problems in aeronautics in an effort to cultivate and foster innovation. This report summarizes several lessons learned from the rapid design portion of the study. This effort entailed learning and applying design thinking, a human-centered design approach, to complete the conceptual design for an open-ended design challenge within six months. The design challenge focused on creating a capability to advance experimental testing of autonomous aeronautics systems, an area of great interest to NASA, the US government as a whole, and an entire ecosystem of users and developers around the globe. A team of nine civil servant researchers from three of NASA's aeronautics field centers with backgrounds in several disciplines was assembled and rapidly trained in design thinking under the guidance of the innovation and design firm IDEO. The design thinking process, while used extensively outside the aerospace industry, is less common and even counter to many practices within the aerospace industry. In this report, several contrasts between common aerospace research and development practices and design thinking are discussed, drawing upon the lessons learned from the NASA rapid design study. The lessons discussed included working towards a design solution without a set of detailed design requirements, which may not be practical or even feasible for management to ascertain for complex, challenging problems. This approach allowed for the possibility of redesigning the original problem statement to better meet the needs of the users. Another lesson learned was to approach problems holistically from the perspective of the needs of individuals that may be affected by advances in topic area instead of purely from a technological feasibility viewpoint. The interdisciplinary nature of the design team also

Building qualitative study design using nursing's disciplinary epistemology.

Science.gov (United States)

Thorne, Sally; Stephens, Jennifer; Truant, Tracy

2016-02-01

To discuss the implications of drawing on core nursing knowledge as theoretical scaffolding for qualitative nursing enquiry. Although nurse scholars have been using qualitative methods for decades, much of their methodological direction derives from conventional approaches developed for answering questions in the social sciences. The quality of available knowledge to inform practice can be enhanced through the selection of study design options informed by an appreciation for the nature of nursing knowledge. Discussion paper. Drawing on the body of extant literature dealing with nursing's theoretical and qualitative research traditions, we consider contextual factors that have shaped the application of qualitative research approaches in nursing, including prior attempts to align method with the structure and form of disciplinary knowledge. On this basis, we critically reflect on design considerations that would follow logically from core features associated with a nursing epistemology. The substantive knowledge used by nurses to inform their practice includes both aspects developed at the level of the general and also that which pertains to application in the unique context of the particular. It must be contextually relevant to a fluid and dynamic healthcare environment and adaptable to distinctive patient conditions. Finally, it must align with nursing's moral mandate and action imperative. Qualitative research design components informed by nursing's disciplinary epistemology will help ensure a logical line of reasoning in our enquiries that remains true to the nature and structure of practice knowledge. © 2015 John Wiley & Sons Ltd.

Uniqueness in time measurement

International Nuclear Information System (INIS)

Lorenzen, P.

1981-01-01

According to P. Janich a clock is defined as an apparatus in which a point ( hand ) is moving uniformly on a straight line ( path ). For the definition of uniformly first the scaling (as a constant ratio of velocities) is defined without clocks. Thereafter the uniqueness of the time measurement can be proved using the prove of scaling of all clocks. But the uniqueness can be defined without scaling, as it is pointed out here. (orig.) [de

First Studies for the Development of Computational Tools for the Design of Liquid Metal Electromagnetic Pumps

Directory of Open Access Journals (Sweden)

Carlos O. Maidana

2017-02-01

Full Text Available Liquid alloy systems have a high degree of thermal conductivity, far superior to ordinary nonmetallic liquids and inherent high densities and electrical conductivities. This results in the use of these materials for specific heat conducting and dissipation applications for the nuclear and space sectors. Uniquely, they can be used to conduct heat and electricity between nonmetallic and metallic surfaces. The motion of liquid metals in strong magnetic fields generally induces electric currents, which, while interacting with the magnetic field, produce electromagnetic forces. Electromagnetic pumps exploit the fact that liquid metals are conducting fluids capable of carrying currents, which is a source of electromagnetic fields useful for pumping and diagnostics. The coupling between the electromagnetics and thermo-fluid mechanical phenomena and the determination of its geometry and electrical configuration, gives rise to complex engineering magnetohydrodynamics problems. The development of tools to model, characterize, design, and build liquid metal thermo-magnetic systems for space, nuclear, and industrial applications are of primordial importance and represent a cross-cutting technology that can provide unique design and development capabilities as well as a better understanding of the physics behind the magneto-hydrodynamics of liquid metals. First studies for the development of computational tools for the design of liquid metal electromagnetic pumps are discussed.

First studies for the development of computational tools for the design of liquid metal electromagnetic pumps

Energy Technology Data Exchange (ETDEWEB)

Maidana, Carlos O.; Nieminen, Juha E. [Maidana Research, Grandville (United States)

2017-02-15

Liquid alloy systems have a high degree of thermal conductivity, far superior to ordinary nonmetallic liquids and inherent high densities and electrical conductivities. This results in the use of these materials for specific heat conducting and dissipation applications for the nuclear and space sectors. Uniquely, they can be used to conduct heat and electricity between nonmetallic and metallic surfaces. The motion of liquid metals in strong magnetic fields generally induces electric currents, which, while interacting with the magnetic field, produce electromagnetic forces. Electromagnetic pumps exploit the fact that liquid metals are conducting fluids capable of carrying currents, which is a source of electromagnetic fields useful for pumping and diagnostics. The coupling between the electromagnetics and thermo-fluid mechanical phenomena and the determination of its geometry and electrical configuration, gives rise to complex engineering magnetohydrodynamics problems. The development of tools to model, characterize, design, and build liquid metal thermo-magnetic systems for space, nuclear, and industrial applications are of primordial importance and represent a cross-cutting technology that can provide unique design and development capabilities as well as a better understanding of the physics behind the magneto-hydrodynamics of liquid metals. First studies for the development of computational tools for the design of liquid metal electromagnetic pumps are discussed.

Design

DEFF Research Database (Denmark)

Volf, Mette

This publication is unique in its demystification and operationalization of the complex and elusive nature of the design process. The publication portrays the designer’s daily work and the creative process, which the designer is a part of. Apart from displaying the designer’s work methods...... and design parameters, the publication shows examples from renowned Danish design firms. Through these examples the reader gets an insight into the designer’s reality....

Alpbach Summer School - a unique learning experience

Science.gov (United States)

Kern, K.; Aulinas, J.; Clifford, D.; Krejci, D.; Topham, R.

2011-12-01

The Alpbach Summer School is a ten-day program that provides a unique opportunity for young european science and engineering students, both undergraduate and graduate, to learn how to approach the entire design process of a space mission. The theme of the 2010 Summer School was "New Space Missions to Understand Climate Change", a current, challenging, very broad and complex topic. The program was established more than 35 years ago and is organised in two interrelated parts: a series of lectures held by renowned experts in the field (in the case of this specific year, climate change and space engineering experts) that provides a technical and scientific background for the workshops that follow, the core of the Summer School. For the workshops the students are split into four international, interdisciplinary teams of about 15 students. In 2010 every team had to complete a number of tasks, four in total: (1) identify climate change research gaps and design a space mission that has not yet been flown or proposed, (2) define the science objectives and requirements of the mission, (3) design a spacecraft that meets the mission requirements, which includes spacecraft design and construction, payload definition, orbit calculations, but also the satellite launch, operation and mission costs and (4) write up a short mission proposal and present the results to an expert review panel. Achieving these tasks in only a few days in a multicultural, interdisciplinary team represents a major challenge for all participants and provides an excellent practical learning experience. Over the course of the program, students do not just learn facts about climate change and space engineering, but scientists also learn from engineers and engineers from scientists. The participants have to deepen their knowledge in an often unfamiliar field, develop organisational and team-work skills and work under pressure. Moreover, teams are supported by team and roving tutors and get the opportunity to

Designing satisfaction studies

DEFF Research Database (Denmark)

Kristensen, Kai; Eskildsen, Jacob Kjær

2007-01-01

In the effect sampling method, presentation of researcher, the intro text, the order of questions in the questionnaire along with the number of categories in the rating scale is tested in relation to the design of satisfaction studies. Based on the analyses specific recommendations for designing...... satisfaction studies are given....

Uniqueness theorems in linear elasticity

CERN Document Server

Knops, Robin John

1971-01-01

The classical result for uniqueness in elasticity theory is due to Kirchhoff. It states that the standard mixed boundary value problem for a homogeneous isotropic linear elastic material in equilibrium and occupying a bounded three-dimensional region of space possesses at most one solution in the classical sense, provided the Lame and shear moduli, A and J1 respectively, obey the inequalities (3 A + 2 J1) > 0 and J1>O. In linear elastodynamics the analogous result, due to Neumann, is that the initial-mixed boundary value problem possesses at most one solution provided the elastic moduli satisfy the same set of inequalities as in Kirchhoffs theorem. Most standard textbooks on the linear theory of elasticity mention only these two classical criteria for uniqueness and neglect altogether the abundant literature which has appeared since the original publications of Kirchhoff. To remedy this deficiency it seems appropriate to attempt a coherent description ofthe various contributions made to the study of uniquenes...

Visual Design Principles: An Empirical Study of Design Lore

Science.gov (United States)

Kimball, Miles A.

2013-01-01

Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

ARAC: A unique command and control resource

Energy Technology Data Exchange (ETDEWEB)

Bradley, M.M.; Baskett, R.L.; Ellis, J.S. [and others

1996-04-01

The Atmospheric Release Advisory Capability (ARAC) at Lawrence Livermore National Laboratory (LLNL) is a centralized federal facility designed to provide real-time, world-wide support to military and civilian command and control centers by predicting the impacts of inadvertent or intentional releases of nuclear, biological, or chemical materials into the atmosphere. ARAC is a complete response system consisting of highly trained and experienced personnel, continually updated computer models, redundant data collection systems, and centralized and remote computer systems. With over 20 years of experience responding to domestic and international incidents, strong linkages with the Department of Defense, and the ability to conduct classified operations, ARAC is a unique command and control resource.

ARAC: A unique command and control resource

International Nuclear Information System (INIS)

Bradley, M.M.; Baskett, R.L.; Ellis, J.S.

1996-04-01

The Atmospheric Release Advisory Capability (ARAC) at Lawrence Livermore National Laboratory (LLNL) is a centralized federal facility designed to provide real-time, world-wide support to military and civilian command and control centers by predicting the impacts of inadvertent or intentional releases of nuclear, biological, or chemical materials into the atmosphere. ARAC is a complete response system consisting of highly trained and experienced personnel, continually updated computer models, redundant data collection systems, and centralized and remote computer systems. With over 20 years of experience responding to domestic and international incidents, strong linkages with the Department of Defense, and the ability to conduct classified operations, ARAC is a unique command and control resource

Marginal and happy? The need for uniqueness predicts the adjustment of marginal immigrants.

Science.gov (United States)

Debrosse, Régine; de la Sablonnière, Roxane; Rossignac-Milon, Maya

2015-12-01

Marginalization is often presented as the strategy associated with the worst adjustment for immigrants. This study identifies a critical variable that buffers marginal immigrants from the negative effects of marginalization on adjustment: The need for uniqueness. In three studies, we surveyed immigrants recruited on university campuses (n = 119, n = 116) and in the field (n = 61). Among marginal immigrants, a higher need for uniqueness predicted higher self-esteem (Study 1), affect (Study 2), and life satisfaction (Study 3), and marginally higher happiness (Study 2) and self-esteem (Study 3). No relationship between the need for uniqueness and adjustment was found among non-marginal immigrants. The adaptive value of the need for uniqueness for marginal immigrants is discussed. © 2015 The British Psychological Society.

Flexible displays as key for high-value and unique automotive design

Science.gov (United States)

Isele, Robert

2011-03-01

Within the last few years' car industry changed very fast. Information and Communication became more important and displays are now standard in nearly every car. But this is not the only trend which could be recognized in this industry. CO2 emission, fuel price as well as the increasing traffic inside the Mega Cities initialized a big change in the behavior of the customers. The big battle for the car industry will enter the interior extremely fast, and the premium cars need ore innovative design icons. Flexible Displays are one big step that enables totally different designs and a new value of the driver experience.

On the Non-Uniqueness of Sediment Yield

Science.gov (United States)

Kim, J.; Ivanov, V. Y.; Fatichi, S.

2014-12-01

There has been ample experimental evidence that soil erosion does not necessarily occur at the same rate, given the same amount of rainfall or runoff. Such a non-unique phenomenon has been often referred to in literature as due to 'natural variability'. Our recent study hypothesized that uncertainties in the distribution and properties of a sediment layer can be a potential clue to one of the reasons of the non-unique sediment yield. Specifically, numerical experimentation with a sophisticated two-dimensional model showed that a deposited layer plays two conflicting roles: it can both increase and decrease soil erosion, given the same magnitude of runoff. The difference in erodibilities of the "original, intact soil layer" and the "deposited, loose soil layer" and the composition of soil particles in the underlying layers give rise to the non-uniqueness of the amount of eroded materials. In continuing efforts, we attempt to investigate this phenomenon using a comprehensive the Universal Soil Loss Erosion (USLE) database, that contains data on paired hillslopes that show a high degree of non-uniqueness in the response, even though the hillslopes exhibit the same topography, soil type, rainfall and meteorological forcings, and landuse. An underlying hypothesis of this study is that uncertainties in the distribution of soil substrate prior to a rainfall event lead to low predictability skill, i.e., a stochastically-varying outcome. A large number of simulation cases demonstrating the proposed hypothesis are conducted using a coupled numerical model, tRIBS-VEGGIE-FEaST (Triangulated irregular network - based Real time Integrated Basin Simulator- VEGetation Generator for Interactive Evolution -Flow Erosion and Sediment Transport).

Addressing Uniqueness and Unison of Reliability and Safety for a Better Integration

Science.gov (United States)

Huang, Zhaofeng; Safie, Fayssal

2016-01-01

Over time, it has been observed that Safety and Reliability have not been clearly differentiated, which leads to confusion, inefficiency, and, sometimes, counter-productive practices in executing each of these two disciplines. It is imperative to address this situation to help Reliability and Safety disciplines improve their effectiveness and efficiency. The paper poses an important question to address, "Safety and Reliability - Are they unique or unisonous?" To answer the question, the paper reviewed several most commonly used analyses from each of the disciplines, namely, FMEA, reliability allocation and prediction, reliability design involvement, system safety hazard analysis, Fault Tree Analysis, and Probabilistic Risk Assessment. The paper pointed out uniqueness and unison of Safety and Reliability in their respective roles, requirements, approaches, and tools, and presented some suggestions for enhancing and improving the individual disciplines, as well as promoting the integration of the two. The paper concludes that Safety and Reliability are unique, but compensating each other in many aspects, and need to be integrated. Particularly, the individual roles of Safety and Reliability need to be differentiated, that is, Safety is to ensure and assure the product meets safety requirements, goals, or desires, and Reliability is to ensure and assure maximum achievability of intended design functions. With the integration of Safety and Reliability, personnel can be shared, tools and analyses have to be integrated, and skill sets can be possessed by the same person with the purpose of providing the best value to a product development.

Co-Designing Mobile Apps to Assist in Clinical Nursing Education: A Study Protocol.

Science.gov (United States)

O'Connor, Siobhan; Andrews, Tom

2016-01-01

Mobile applications (apps) to train health professionals is gaining momentum as the benefits of mobile learning (mLearning) are becoming apparent in complex clinical environments. However, most educational apps are generic, off-the-shelf pieces of software that do not take into consideration the unique needs of nursing students. The proposed study will apply a user-centred design process to create a tailored mobile app for nursing students to learn and apply clinical skills in practice. The app will be piloted and evaluated to understand how nursing students use mobile technology in clinical settings to support their learning and educational needs.

Fusion-driven actinide burner design study. Second quarterly progress report

International Nuclear Information System (INIS)

Chi, J.W.H.; Gold, R.E.; Holman, R.R.

1975-11-01

The Second Quarterly Progress Report summarizes the status at the mid-point of the conceptual design effort. The fusion driver continues to pose some of the principal design problems due to the necessity of advancing plasma engineering and technology for long pulse, high duty cycle operation. The development of credible design solutions to these problems is one of the major objectives of the study. The TF and OH coil designs have been modified to provide a more compact arrangement in the nose region of the TF coils and to ensure fully cryostable operation. A unique concept has been developed to effectively shield the TF coils from the poloidal fields. A vacuum vessel concept which separates the functions for sustaining the differential pressure load and for sealing the vacuum system is described. The thickness of the blanket has been decreased to reduce the power density and the actinide inventory. Determination and presentation of actinide depletion characteristics represents a major element thus far in the study and is a principal objective. Evaluation of the changes in the hazard only during irradiation proved to be an inadequate measure of the reduction in long term hazards due to the importance of radioactive daughter products which appear much later in time. Therefore, comparisons have been made of long term decay characteristics before and after irradiation in the actinide burner. It has also been noted that some of the actinides that are produced during irradiation have beneficial applications as radioisotopic power sources. These and other considerations suggest that alternate approaches to assessing the waste management problem be considered to develop a meaningful perspective on long term hazards from the actinides

Fusion-driven actinide burner design study. Second quarterly progress report

Energy Technology Data Exchange (ETDEWEB)

Chi, J.W.H.; Gold, R.E.; Holman, R.R.

1975-11-01

The Second Quarterly Progress Report summarizes the status at the mid-point of the conceptual design effort. The fusion driver continues to pose some of the principal design problems due to the necessity of advancing plasma engineering and technology for long pulse, high duty cycle operation. The development of credible design solutions to these problems is one of the major objectives of the study. The TF and OH coil designs have been modified to provide a more compact arrangement in the nose region of the TF coils and to ensure fully cryostable operation. A unique concept has been developed to effectively shield the TF coils from the poloidal fields. A vacuum vessel concept which separates the functions for sustaining the differential pressure load and for sealing the vacuum system is described. The thickness of the blanket has been decreased to reduce the power density and the actinide inventory. Determination and presentation of actinide depletion characteristics represents a major element thus far in the study and is a principal objective. Evaluation of the changes in the hazard only during irradiation proved to be an inadequate measure of the reduction in long term hazards due to the importance of radioactive daughter products which appear much later in time. Therefore, comparisons have been made of long term decay characteristics before and after irradiation in the actinide burner. It has also been noted that some of the actinides that are produced during irradiation have beneficial applications as radioisotopic power sources. These and other considerations suggest that alternate approaches to assessing the waste management problem be considered to develop a meaningful perspective on long term hazards from the actinides.

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes.

Science.gov (United States)

Kehr, Jan-Christoph; Gatte Picchi, Douglas; Dittmann, Elke

2011-01-01

Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms. In this article, we survey the biosynthetic pathways of cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathways and highlight the unique enzyme mechanisms that were elucidated or can be anticipated for the individual products. We further include ribosomal natural products and UV-absorbing pigments from cyanobacteria. Mechanistic insights obtained from the biochemical studies of cyanobacterial pathways can inspire the development of concepts for the design of bioactive compounds by synthetic-biology approaches in the future.

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

Directory of Open Access Journals (Sweden)

Jan-Christoph Kehr

2011-12-01

Full Text Available Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms. In this article, we survey the biosynthetic pathways of cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS and polyketide synthase (PKS pathways and highlight the unique enzyme mechanisms that were elucidated or can be anticipated for the individual products. We further include ribosomal natural products and UV-absorbing pigments from cyanobacteria. Mechanistic insights obtained from the biochemical studies of cyanobacterial pathways can inspire the development of concepts for the design of bioactive compounds by synthetic-biology approaches in the future.

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components

Science.gov (United States)

Ong, Luvena L.; Hanikel, Nikita; Yaghi, Omar K.; Grun, Casey; Strauss, Maximilian T.; Bron, Patrick; Lai-Kee-Him, Josephine; Schueder, Florian; Wang, Bei; Wang, Pengfei; Kishi, Jocelyn Y.; Myhrvold, Cameron; Zhu, Allen; Jungmann, Ralf; Bellot, Gaetan; Ke, Yonggang; Yin, Peng

2017-12-01

Nucleic acids (DNA and RNA) are widely used to construct nanometre-scale structures with ever increasing complexity, with possible application in fields such as structural biology, biophysics, synthetic biology and photonics. The nanostructures are formed through one-pot self-assembly, with early kilodalton-scale examples containing typically tens of unique DNA strands. The introduction of DNA origami, which uses many staple strands to fold one long scaffold strand into a desired structure, has provided access to megadalton-scale nanostructures that contain hundreds of unique DNA strands. Even larger DNA origami structures are possible, but manufacturing and manipulating an increasingly long scaffold strand remains a challenge. An alternative and more readily scalable approach involves the assembly of DNA bricks, which each consist of four short binding domains arranged so that the bricks can interlock. This approach does not require a scaffold; instead, the short DNA brick strands self-assemble according to specific inter-brick interactions. First-generation bricks used to create three-dimensional structures are 32 nucleotides long, consisting of four eight-nucleotide binding domains. Protocols have been designed to direct the assembly of hundreds of distinct bricks into well formed structures, but attempts to create larger structures have encountered practical challenges and had limited success. Here we show that DNA bricks with longer, 13-nucleotide binding domains make it possible to self-assemble 0.1-1-gigadalton, three-dimensional nanostructures from tens of thousands of unique components, including a 0.5-gigadalton cuboid containing about 30,000 unique bricks and a 1-gigadalton rotationally symmetric tetramer. We also assembled a cuboid that contains around 10,000 bricks and about 20,000 uniquely addressable, 13-base-pair ‘voxels’ that serves as a molecular canvas for three-dimensional sculpting. Complex, user-prescribed, three-dimensional cavities can

Increasing Need for Uniqueness in Contemporary China: Empirical Evidence

Directory of Open Access Journals (Sweden)

Huajian Cai

2018-05-01

Full Text Available Past research has documented various cultural and psychological changes in contemporary China. In two studies, we examine how Chinese people’s need for uniqueness (NFU also has changed. In Study 1, we found a significant cross-generational increase in Chinese participants’ self-reported NFU. In Study 2, we sampled the names of Chinese newborn babies over the last five decades and found that parents have been increasingly likely to use unique characters to name their children. These findings suggest that the NFU has been rising in China, a historically collectivistic-oriented society. Theoretical and practical implications of our findings were discussed.

Unique interconnected graphene/SnO2 nanoparticle spherical multilayers for lithium-ion battery applications.

Science.gov (United States)

Shao, Qingguo; Tang, Jie; Sun, Yige; Li, Jing; Zhang, Kun; Yuan, Jinshi; Zhu, Da-Ming; Qin, Lu-Chang

2017-03-30

We have designed and synthesized a unique structured graphene/SnO 2 composite, where SnO 2 nanoparticles are inserted in between interconnected graphene sheets which form hollow spherical multilayers. The hollow spherical multilayered structure provides much flexibility to accommodate the configuration and volume changes of SnO 2 in the material. When it is used as an anode material for lithium-ion batteries, such a novel nanostructure can not only provide a stable conductive matrix and suppress the mechanical stress, but also eliminate the need of any binders for constructing electrodes. Electrochemical tests show that the unique graphene/SnO 2 composite electrode as designed could exhibit a large reversible capacity over 1000 mA h g -1 and long cycling life with 88% retention after 100 cycles. These results indicate the great potential of the composite for being used as a high performance anode material for lithium-ion batteries.

Unmanned Aerial Vehicles unique cost estimating requirements

Science.gov (United States)

Malone, P.; Apgar, H.; Stukes, S.; Sterk, S.

Unmanned Aerial Vehicles (UAVs), also referred to as drones, are aerial platforms that fly without a human pilot onboard. UAVs are controlled autonomously by a computer in the vehicle or under the remote control of a pilot stationed at a fixed ground location. There are a wide variety of drone shapes, sizes, configurations, complexities, and characteristics. Use of these devices by the Department of Defense (DoD), NASA, civil and commercial organizations continues to grow. UAVs are commonly used for intelligence, surveillance, reconnaissance (ISR). They are also use for combat operations, and civil applications, such as firefighting, non-military security work, surveillance of infrastructure (e.g. pipelines, power lines and country borders). UAVs are often preferred for missions that require sustained persistence (over 4 hours in duration), or are “ too dangerous, dull or dirty” for manned aircraft. Moreover, they can offer significant acquisition and operations cost savings over traditional manned aircraft. Because of these unique characteristics and missions, UAV estimates require some unique estimating methods. This paper describes a framework for estimating UAV systems total ownership cost including hardware components, software design, and operations. The challenge of collecting data, testing the sensitivities of cost drivers, and creating cost estimating relationships (CERs) for each key work breakdown structure (WBS) element is discussed. The autonomous operation of UAVs is especially challenging from a software perspective.

Repository design sensitivity study: Engineering study report

International Nuclear Information System (INIS)

1987-01-01

A preliminary sensitivity study of the salt repository design has been performed to identify critical site and design parameters to help guide future site characterization and design optimization activities. The study considered the SCP-conceptual design at the Deaf Smith County site in Texas with the horizontal waste package emplacement mode as the base case. Relative to this base case, parameter variations were compared. Limited studies were performed which considered the vertical emplacement mode geometry. The report presents the reference data base and design parameters on which the study was based (including the range of parameters that might be expected). Detailed descriptions of the numerical modeling methods and assumptions are included for the thermal, thermomechanical and hydrogeological analyses. The impacts of parameter variations on the sensitivity of the rock mass response are discussed. Recommendations are provided to help guide site characterization activities and advanced conceptual design optimization activities. 47 refs., 119 refs., 22 tabs

Crew emergency return vehicle - Electrical power system design study

Science.gov (United States)

Darcy, E. C.; Barrera, T. P.

1989-01-01

A crew emergency return vehicle (CERV) is proposed to perform the lifeboat function for the manned Space Station Freedom. This escape module will be permanently docked to Freedom and, on demand, will be capable of safely returning the crew to earth. The unique requirements that the CERV imposes on its power source are presented, power source options are examined, and a baseline system is selected. It consists of an active Li-BCX DD-cell modular battery system and was chosen for the maturity of its man-rated design and its low development costs.

Evaluating the Physical Environment of Design Studios: A Case study in Malaysian Private Architecture Schools

OpenAIRE

Shanthi Muniandy; Tareef Hayat Khan; Abdullah Sani Ahmad

2015-01-01

Understanding the notion of learner’s experiences in the design of physical environment of an architecture design studio is a necessity as it contains certain values of influence. It is due to the unique learning experiences which are accrued particularly in design studio that is continued during professional practice as well. Most architectural campuses in Malaysian Private Higher Education Institutions (MPHEI) are devoid of certain important elements and this issue needs to be looked into s...

Heart Failure: Unique to Older Adults

Science.gov (United States)

... to Z › Heart Failure › Unique to Older Adults Font size A A A Print Share Glossary Unique ... will suffer from depression at some point. This type of severe depression is more serious than the ...

The radiologic technologists' health study in South Korea: study design and baseline results.

Science.gov (United States)

Lee, Won Jin; Ha, Mina; Hwang, Seung-sik; Lee, Kyoung-Mu; Jin, Young-Woo; Jeong, Meeseon; Jun, Jae Kwan; Cha, Eun Shil; Ko, Yousun; Choi, Kyung-Hwa; Lee, Jung-Eun

2015-08-01

To describe the study design, methods, and baseline results of a prospective cohort of radiologic technologists which we have initiated in South Korea. The cohort participants were enrolled through a self-administered questionnaire survey administered from April 2012 to May 2013. Survey data were linked with radiation dosimetry, a cancer registry, and health insurance data by personal identification numbers. A nationwide representative survey was also conducted using a stratified random sampling design with face-to-face interviews. A total of 12,387 radiologic technologists were enrolled, which accounted for approximately 63% of all diagnostic radiologic technologists working in South Korea. For nationwide survey, 585 workers were interviewed using the detailed questionnaire, and buccal cells were also collected by scraping the inside of the cheek. The majority of study subjects were under 50-year-old and male workers. The average annual effective dose of radiation declined both men (from 2.75 to 1.43 mSv) and women (from 1.34 to 0.95 mSv) over the period of 1996-2011. A total of 99 cancers (66 cancers in men and 33 in women) were reported from 1992 to 2010. The standardized incidence ratio of all cancer combined was significantly lower in men (SIR = 0.75, 95% CI 0.58-0.96) than general population, but the ratios for thyroid cancer were significantly higher than expected among both men and women. This cohort provides comprehensive information on work activities and health status of diagnostic radiologic technologists. In addition, the nationwide representative sample provides unique opportunities compared with previous radiologic technologist studies.

The radiologic technologists' health study in South Korea. Study design and baseline results

International Nuclear Information System (INIS)

Lee, Won Jin; Ha, Mina; Hwang, Seung-sik

2015-01-01

To describe the study design, methods, and baseline results of a prospective cohort of radiologic technologists which we have initiated in South Korea. The cohort participants were enrolled through a self-administered questionnaire survey administered from April 2012 to May 2013. Survey data were linked with radiation dosimetry, a cancer registry, and health insurance data by personal identification numbers. A nationwide representative survey was also conducted using a stratified random sampling design with face-to-face interviews. A total of 12,387 radiologic technologists were enrolled, which accounted for approximately 63 % of all diagnostic radiologic technologists working in South Korea. For nationwide survey, 585 workers were interviewed using the detailed questionnaire, and buccal cells were also collected by scraping the inside of the cheek. The majority of study subjects were under 50-year-old and male workers. The average annual effective dose of radiation declined both men (from 2.75 to 1.43 mSv) and women (from 1.34 to 0.95 mSv) over the period of 1996-2011. A total of 99 cancers (66 cancers in men and 33 in women) were reported from 1992 to 2010. The standardized incidence ratio of all cancer combined was significantly lower in men (SIR = 0.75, 95 % CI 0.58-0.96) than general population, but the ratios for thyroid cancer were significantly higher than expected among both men and women. This cohort provides comprehensive information on work activities and health status of diagnostic radiologic technologists. In addition, the nationwide representative sample provides unique opportunities compared with previous radiologic technologist studies.

Pinning Design: The Curatorial Labor of Creative Professionals

Directory of Open Access Journals (Sweden)

Leah Scolere

2016-02-01

Full Text Available Pinterest is a site primarily used for sharing online content particularly images; as such, it is a unique platform through which to explore curatorial practices. Professional designers are a unique community of interest because their expertise in the offline curation of visual images is central to their professional work. Drawing on digital curation, convergence culture, and creative professionals, this study examined the curatorial labor practices of design professionals on Pinterest. Through a series of in-depth qualitative interviews and online observation of design professionals, we identify three aspects of curatorial labor on Pinterest: (1 performance, (2 process, and (3 product. The strategic and creative selection and arrangement of digital images by these designers becomes an ongoing authorial act of creative labor. This community demonstrates how the public digital curation of visual images is an important part of the ongoing venture labor of design professionals. The study concludes with implications for our collective understandings of online curation, creative professional labor, and the role of social media within commercial and organizational contexts.

Performance optimization of an online retailer by a unique online resilience engineering algorithm

Science.gov (United States)

Azadeh, A.; Salehi, V.; Salehi, R.; Hassani, S. M.

2018-03-01

Online shopping has become more attractive and competitive in electronic markets. Resilience engineering (RE) can help such systems divert to the normal state in case of encountering unexpected events. This study presents a unique online resilience engineering (ORE) approach for online shopping systems and customer service performance. Moreover, this study presents a new ORE algorithm for the performance optimisation of an actual online shopping system. The data are collected by standard questionnaires from both expert employees and customers. The problem is then formulated mathematically using data envelopment analysis (DEA). The results show that the design process which is based on ORE is more efficient than the conventional design approach. Moreover, on-time delivery is the most important factor from the personnel's perspective. In addition, according to customers' view, trust, security and good quality assurance are the most effective factors during transactions. This is the first study that introduces ORE for electronic markets. Second, it investigates impact of RE on online shopping through DEA and statistical methods. Third, a practical approach is employed in this study and it may be used for similar online shops. Fourth, the results are verified and validated through complete sensitivity analysis.

The end of the unique myocardial band

DEFF Research Database (Denmark)

MacIver, David H; Partridge, John B; Agger, Peter

2018-01-01

Two of the leading concepts of mural ventricular architecture are the unique myocardial band and the myocardial mesh model. We have described, in an accompanying article published in this journal, how the anatomical, histological and high-resolution computed tomographic studies strongly favour th...

Social Interaction Needs and Entertainment Approaches to Pregnancy Well-Being in mHealth Technology Design for Low-Income Transmigrant Women: Qualitative Codesign Study.

Science.gov (United States)

AlJaberi, Hana

2018-04-13

Low-income Caribbean transmigrant women face unique health challenges during pregnancy that set forth multidimensional implications for the design of mobile health (mHealth). Acknowledgment of the unique health needs of low-income Caribbean immigrant women in the United States and what that entails regarding technology design remains rarely examined in the literature of mHealth technologies. The goal of this study was to reveal the needs and gaps in mHealth interventions for pregnant immigrant women not yet realized in this field. These understandings reveal design opportunities for mHealth. The use of the qualitative participatory action research approach of codesign workshops in this study resulted in design solutions by the participants after reflecting on their earlier focus group discussions. The highlights are not the resulting designs per se but rather the inferences derived from the researcher reflecting on these designs. The designs exposed two themes relevant to this paper. First, the participants desired the inclusion and rebuilding of social and organizational relationships in mHealth. The resulting designs formulate an understanding of the women's health-related social support needs and how technology can facilitate them. Second, the participants wanted entertainment with an element of social participation incorporated in mHealth pregnancy management interventions. This brings attention to the role entertainment can add to the impact mHealth can deliver for pregnancy well-being. The study concluded with an examination of social and entertainment design implications that reveal pregnant immigrant women's virtual health-related sharing habits, choice of sharing interaction scenarios during pregnancy (eg, local, long distance, one-way, two-way, and many-many), and choice of sharing media (eg, text, voice, and video). Additionally, the study revealed exclusions to social sharing capabilities in health technologies for these women. ©Hana Al

Design and Co-design of Project-organized Studies

DEFF Research Database (Denmark)

Nielsen, Jørgen Lerche; Andreasen, Lars Birch

2014-01-01

The chapter contributes to discussions on design processes in relation to education, presenting different notions of design research and demonstrating how professors and students are involved together in designing innovative and constructive study processes that can help foster students' engagement...

Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Science.gov (United States)

Battaglia, Manuela; Anderson, Mark S; Buckner, Jane H; Geyer, Susan M; Gottlieb, Peter A; Kay, Thomas W H; Lernmark, Åke; Muller, Sarah; Pugliese, Alberto; Roep, Bart O; Greenbaum, Carla J; Peakman, Mark

2017-11-01

Type 1 diabetes is an autoimmune disease arising from the destruction of pancreatic insulin-producing beta cells. The disease represents a continuum, progressing sequentially at variable rates through identifiable stages prior to the onset of symptoms, through diagnosis and into the critical periods that follow, culminating in a variable depth of beta cell depletion. The ability to identify the very earliest of these presymptomatic stages has provided a setting in which prevention strategies can be trialled, as well as furnishing an unprecedented opportunity to study disease evolution, including intrinsic and extrinsic initiators and drivers. This niche opportunity is occupied by Type 1 Diabetes TrialNet, an international consortium of clinical trial centres that leads the field in intervention and prevention studies, accompanied by deep longitudinal bio-sampling. In this review, we focus on discoveries arising from this unique bioresource, comprising more than 70,000 samples, and outline the processes and science that have led to new biomarkers and mechanistic insights, as well as identifying new challenges and opportunities. We conclude that via integration of clinical trials and mechanistic studies, drawing in clinicians and scientists and developing partnership with industry, TrialNet embodies an enviable and unique working model for understanding a disease that to date has no cure and for designing new therapeutic approaches.

Unique Non-Keplerian Orbit Vantage Locations for Sun-Earth Connection and Earth Science Vision Roadmaps

Science.gov (United States)

Folta, David; Young, Corissa; Ross, Adam

2001-01-01

The purpose of this investigation is to determine the feasibility of attaining and maintaining unique non-Keplerian orbit vantage locations in the Earth/Moon environment in order to obtain continuous scientific measurements. The principal difficulty associated with obtaining continuous measurements is the temporal nature of astrodynamics, i.e., classical orbits. This investigation demonstrates advanced trajectory designs to meet demanding science requirements which cannot be met following traditional orbital mechanic logic. Examples of continuous observer missions addressed include Earth pole-sitters and unique vertical libration orbits that address Sun-Earth Connection and Earth Science Vision roadmaps.

Esperanto: A Unique Model for General Linguistics.

Science.gov (United States)

Dulichenko, Aleksandr D.

1988-01-01

Esperanto presents a unique model for linguistic research by allowing the study of language development from project to fully functioning language. Esperanto provides insight into the growth of polysemy and redundancy, as well as into language universals and the phenomenon of social control. (Author/CB)

Being and feeling unique: statistical deviance and psychological marginality.

Science.gov (United States)

Frable, D E

1993-03-01

Two studies tested the hypothesis that people with culturally stigmatized and concealable conditions (e.g., gays, epileptics, juvenile delinquents, and incest victims) would be more likely to feel unique than people with culturally valued or conspicuous conditions (e.g., the physically attractive, the intellectually gifted, the obese, and the facially scarred). In Study 1, culturally stigmatized individuals with concealable conditions were least likely to perceive consensus between their personal preferences and those of others. In Study 2, they were most likely to describe themselves as unique and to make these self-relevant decisions quickly. Marginality is a psychological reality, not just a statistical one, for those with stigmatized and concealable "master status" conditions.

Considering dance practices as unique cases in interdisciplinary research studies

DEFF Research Database (Denmark)

Ravn, Susanne

” (Flyvbjerg, 2011) in the domain of qualitative research. Such designs are of specific relevance for research projects exploring body, movement and sensing in general. Thereafter I present the results of some of my resent studies. These studies are based in a critical constructive interdisciplinary......The aim of this paper is to present interdisciplinary considerations of relevance to strengthen dance research in relation to – and in cooperation with - other academic disciplines. I firstly describe how dance practices can be handled as “extreme cases” and cases with “maximal variations...

The L3+C detector, a unique tool-set to study cosmic rays

International Nuclear Information System (INIS)

Adriani, O.; Akker, M. van den; Banerjee, S.; Baehr, J.; Betev, B.; Bourilkov, D.; Bottai, S.; Bobbink, G.; Cartacci, A.; Chemarin, M.; Chen, G.; Chen, H.S.; Chiarusi, T.; Dai, C.J.; Ding, L.K.; Duran, I.; Faber, G.; Fay, J.; Grabosch, H.J.; Groenstege, H.; Guo, Y.N.; Gupta, S.; Haller, Ch.; Hayashi, Y.; He, Z.X.; Hebbeker, T.; Hofer, H.; Hoferjun, H.; Huo, A.X.; Ito, N.; Jing, C.L.; Jones, L.; Kantserov, V.; Kawakami, S.; Kittel, W.; Koenig, A.C.; Kok, E.; Korn, A.; Kuang, H.H.; Kuijpers, J.; Ladron de Guevara, P.; Le Coultre, P.; Lei, Y.; Leich, H.; Leiste, R.; Li, D.; Li, L.; Li, Z.C.; Liu, Z.A.; Liu, H.T.; Lohmann, W.; Lu, Y.S.; Ma, X.H.; Ma, Y.Q.; Mil, A. van; Monteleoni, B.; Nahnhauer, R.; Pauss, F.; Parriaud, J.-F.; Petersen, B.; Pohl, M.; Qing, C.R.; Ramelli, R.; Ravindran, K.C.; Rewiersma, P.; Rojkov, A.; Saidi, R.; Schmitt, V.; Schoeneich, B.; Schotanus, D.J.; Shen, C.Q.; Sulanke, H.; Tang, X.W.; Timmermans, C.; Tonwar, S.; Trowitzsch, G.; Unger, M.; Verkooijen, H.; Wang, X.L.; Wang, X.W.; Wang, Z.M.; Wijk, R. van; Wijnen, Th.A.M.; Wilkens, H.; Xu, Y.P.; Xu, Z.Z.; Yang, C.G.; Yang, X.F.; Yao, Z.G.; Yu, Z.Q.; Zhang, S.; Zhu, G.Y.; Zhu, Q.Q.; Zhuang, H.L.; Zwart, A.N.M.

2002-01-01

The L3 detector at the CERN electron-positron collider, LEP, has been employed for the study of cosmic ray muons. The muon spectrometer of L3 consists of a set of high-precision drift chambers installed inside a magnet with a volume of about 1000 m 3 and a field of 0.5 T. Muon momenta are measured with a resolution of a few percent at 50 GeV. The detector is located under 30 m of overburden. A scintillator air shower array of 54 m by 30 m is installed on the roof of the surface hall above L3 in order to estimate the energy and the core position of the shower associated with a sample of detected muons. Thanks to the unique properties of the L3+C detector, muon research topics relevant to various current problems in cosmic ray and particle astrophysics can be studied

The L3+C detector, a unique tool-set to study cosmic rays

CERN Document Server

Adriani, O; Banerjee, S; Bähr, J; Betev, B L; Bourilkov, D; Bottai, S; Bobbink, Gerjan J; Cartacci, A M; Chemarin, M; Chen, G; Chen He Sheng; Chiarusi, T; Dai Chang Jiang; Ding, L K

2002-01-01

The L3 detector at the CERN electron-positron collider, LEP, has been employed for the study of cosmic ray muons. The muon spectrometer of L3 consists of a set of high-precision drift chambers installed inside a magnet with a volume of about 1000 m**3 and a field of 0.5 T. Muon momenta are measured with a resolution of a few percent at 50 GeV. The detector is located under 30 m of overburden. A scintillator air shower array of 54 m by 30 m is installed on the roof of the surface hall above L3 in order to estimate the energy and the core position of the shower associated with a sample of detected muons. Thanks to the unique properties of the L3+C detector, muon research topics relevant to various current problems in cosmic ray and particle astrophysics can be studied.

Parental Expressivity and Parenting Styles in Chinese Families: Prospective and Unique Relations to Children's Psychological Adjustment.

Science.gov (United States)

Chen, Stephen H; Zhou, Qing; Eisenberg, Nancy; Valiente, Carlos; Wang, Yun

2011-01-01

OBJECTIVES: Parents from different cultures differ in how frequently they express emotions. However, the generalizability of the relations between parental expressivity and child adjustment in non-Western cultures has not been extensively studied. The goal of the present study was to investigate prospective relations between parental expressivity within the family (positive, negative dominant, and negative submissive expressivity) and Chinese children's psychological adjustment, above and beyond parenting styles. DESIGN: The study used two waves (3.8 years apart) of longitudinal data from a sample (n= 425) of children in Beijing (mean ages = 7.7 years at T1 and 11.6 years at T2). Parental expressivity and parenting styles were self-reported. To reduce the potential measurement overlap, items that tap parental expression of emotions toward the child were removed from the parenting style measure. Children's adjustment was measured with parents', teachers', and peers' or children's reports. RESULTS: Consistent with findings with European American samples, parental negative dominant expressivity uniquely and positively predicted Chinese children's externalizing problems controlling for prior externalizing problems, parenting styles, and family SES. Neither parental expressivity nor parenting styles uniquely predicted social competence. CONCLUSIONS: Despite previously reported cultural differences in the mean levels of parental expressivity, some of the socialization functions of parental expressivity found in Western countries can be generalized to Chinese families. Although parental expressivity and parenting styles are related constructs, their unique relations to child's adjustment suggest that they should be examined as distinct processes.

Gallium a unique anti-resorptive agent in bone: Preclinical studies on its mechanisms of action

International Nuclear Information System (INIS)

Bockman, R.; Adelman, R.; Donnelly, R.; Brody, L.; Warrell, R.; Jones, K.W.

1990-01-01

The discovery of gallium as a new and unique agent for the treatment of metabolic bone disorders was in part fortuitous. Gallium is an exciting new therapeutic agent for the treatment of pathologic states characterized by accelerated bone resorption. Compared to other therapeutic metal compounds containing platinum or germanium, gallium affects its antiresorptive action without any evidence of a cytotoxic effect on bone cells. Gallium is unique amongst all therapeutically available antiresorptive agents in that it favors bone formation. 18 refs., 1 fig

Duality based direct resolution of unique profiles using zero concentration region information.

Science.gov (United States)

Tavakkoli, Elnaz; Rajkó, Róbert; Abdollahi, Hamid

2018-07-01

Self Modeling Curve Resolution (SMCR) is a class of techniques concerned with estimating pure profiles underlying a set of measurements on chemical systems. In general, the estimated profiles are ambiguous (non-unique) except if some special conditions fulfilled. Implementing the adequate information can reduce the so-called rotational ambiguity effectively, and in the most desirable cases lead to the unique solution. Therefore, studies on circumstances resulting in unique solution are of particular importance. The conditions of unique solution can particularly be studied based on duality principle. In bilinear chemical (e.g., spectroscopic) data matrix, there is a natural duality between its row and column vector spaces using minimal constraints (non-negativity of concentrations and absorbances). In this article, the conditions of the unique solution according to duality concept and using zero concentration region information is intended to show. A simulated dataset of three components and an experimental system with synthetic mixtures containing three amino acids tyrosine, phenylalanine and tryptophan are analyzed. It is shown that in the presence of sufficient information, the reliable unique solution is obtained that is valuable in analytical qualification and for quantitative verification analysis. Copyright © 2018 Elsevier B.V. All rights reserved.

Unique specification of Yang-Mills solutions

International Nuclear Information System (INIS)

Campbell, W.B.; Joseph, D.W.; Morgan, T.A.

1980-01-01

Screened time-independent cylindrically-symmetric solutions of Yang-Mills equations are given which show that the source does not uniquely determine the field. However, these particular solutions suggest a natural way of uniquely specifying solutions in terms of a physical realization of a symmetry group. (orig.)

Unique properties associated with normal martensitic transition and strain glass transition – A simulation study

International Nuclear Information System (INIS)

Wang, Dong; Ni, Yan; Gao, Jinghui; Zhang, Zhen; Ren, Xiaobing; Wang, Yunzhi

2013-01-01

Highlights: ► We model the unique properties of strain glass which is different from that of normal martensite. ► We describe the importance of point defects in the formation of strain glass and related properties. ► The role of point defect can be attributed to global transition temperature effect (GTTE) and local field effect (LFE). -- Abstract: The transition behavior and unique properties associated with normal martensitic transition and strain glass transition are investigated by computer simulations using the phase field method. The simulations are based on a physical model that assumes that point defects alter the thermodynamic stability of martensite and create local lattice distortion. The simulation results show that strain glass transition exhibits different properties from those found in normal martensitic transformations. These unique properties include diffuse scattering pattern, “smear” elastic modulus peak, disappearance of heat flow peak and non-ergodicity. These simulation predictions agree well with the experimental observations

Improving the analysis of designed studies by combining statistical modelling with study design information

NARCIS (Netherlands)

Thissen, U.; Wopereis, S.; Berg, S.A.A. van den; Bobeldijk, I.; Kleemann, R.; Kooistra, T.; Dijk, K.W. van; Ommen, B. van; Smilde, A.K.

2009-01-01

Background: In the fields of life sciences, so-called designed studies are used for studying complex biological systems. The data derived from these studies comply with a study design aimed at generating relevant information while diminishing unwanted variation (noise). Knowledge about the study

DNA origami design of 3D nanostructures

DEFF Research Database (Denmark)

Andersen, Ebbe Sloth; Nielsen, Morten Muhlig

2009-01-01

[8]. We have recently developed a semi-automated DNA origami software package [9] that uses a 2D sequence editor in conjunction with several automated tools to facilitate the design process. Here we extend the use of the program for designing DNA origami structures in 3D and show the application......Structural DNA nanotechnology has been heavily dependent on the development of dedicated software tools for the design of unique helical junctions, to define unique sticky-ends for tile assembly, and for predicting the products of the self-assembly reaction of multiple DNA strands [1-3]. Recently......, several dedicated 3D editors for computer-aided design of DNA structures have been developed [4-7]. However, many of these tools are not efficient for designing DNA origami structures that requires the design of more than 200 unique DNA strands to be folded along a scaffold strand into a defined 3D shape...

Mathematical models used to inform study design or surveillance systems in infectious diseases: a systematic review.

Science.gov (United States)

Herzog, Sereina A; Blaizot, Stéphanie; Hens, Niel

2017-12-18

Mathematical models offer the possibility to investigate the infectious disease dynamics over time and may help in informing design of studies. A systematic review was performed in order to determine to what extent mathematical models have been incorporated into the process of planning studies and hence inform study design for infectious diseases transmitted between humans and/or animals. We searched Ovid Medline and two trial registry platforms (Cochrane, WHO) using search terms related to infection, mathematical model, and study design from the earliest dates to October 2016. Eligible publications and registered trials included mathematical models (compartmental, individual-based, or Markov) which were described and used to inform the design of infectious disease studies. We extracted information about the investigated infection, population, model characteristics, and study design. We identified 28 unique publications but no registered trials. Focusing on compartmental and individual-based models we found 12 observational/surveillance studies and 11 clinical trials. Infections studied were equally animal and human infectious diseases for the observational/surveillance studies, while all but one between humans for clinical trials. The mathematical models were used to inform, amongst other things, the required sample size (n = 16), the statistical power (n = 9), the frequency at which samples should be taken (n = 6), and from whom (n = 6). Despite the fact that mathematical models have been advocated to be used at the planning stage of studies or surveillance systems, they are used scarcely. With only one exception, the publications described theoretical studies, hence, not being utilised in real studies.

Anniversary Emblem & Logotype Designs

Directory of Open Access Journals (Sweden)

Çağlar Okur

2015-12-01

Full Text Available Corporate anniversaries are mostly used as a promotional event to increase the value of corporate identity of firms, business enterprises or their brands. They are also used to create investment trust or strengthen the relations between, employees and customers. What makes corporate anniversaries meaningful is the importance of their moral value of continuity. Signs that are designed to identify these moral values and indicate the anniversaries can be defined as “anniversary emblems.” The design and uniqueness of these emblems are important in the means of being remarkable and memorable. Thus creative and unique results can be achieved by converting the numbers of anniversaries into expressive signs. This article focuses on existing design approaches and examples of anniversary emblem designs.

1300°F 800 MWe USC CFB Boiler Design Study

Science.gov (United States)

Robertson, Archie; Goidich, Steve; Fan, Zhen

Concern about air emissions and the effect on global warming is one of the key factors for developing and implementing new advanced energy production solutions today. One state-of-the-art solution is circulating fluidized bed (CFB) combustion technology combined with a high efficiency once-through steam cycle. Due to this extremely high efficiency, the proven CFB technology offers a good solution for CO2 reduction. Its excellent fuel flexibility further reduces CO2 emissions by co-firing coal with biomass. Development work is under way to offer CFB technology up to 800MWe capacities with ultra-supercritical (USC) steam parameters. In 2009 a 460MWe once-through supercritical (OTSC) CFB boiler designed and constructed by Foster Wheeler will start up. However, scaling up the technology further to 600-800MWe with net efficiency of 45-50% is needed to meet the future requirements of utility operators. To support the move to these larger sizes, an 800MWe CFB boiler conceptual design study was conducted and is reported on herein. The use of USC conditions (˜11 00°F steam) was studied and then the changes, that would enable the unit to generate 1300°F steam, were identified. The study has shown that by using INTREX™ heat exchangers in a unique internal-external solids circulation arrangement, Foster Wheeler's CFB boiler configuration can easily accommodate 1300°F steam and will not require a major increase in heat transfer surface areas.

Thermal and mechanical design of WITAMIR-I blanket

International Nuclear Information System (INIS)

Sze, D.K.; Sviatoslavsky, I.N.

1980-10-01

The design philosophy of WITAMIR-I, a Wisconsin Tandem Mirror Reactor design study, uses the experience obtained from our previous tokamak studies and combines it with the unique features of the tandem mirror to obtain an attractive design of a TM power reactor. It is aimed at maximizing the strengths of the tandem mirror while mitigating its weaknesses. The end product should be a safe, reliable, maintainable and a relatively economic power reactor. The general description of the reactor, the plasma calculations, the magnet design, the neutronic calculations and the maintenance considerations are presented elsewhere. This paper presents the blanket design of this reactor study

Unveiling the 'unique bone': a study of the distribution of focal clavicular lesions

International Nuclear Information System (INIS)

Suresh, S.; Saifuddin, A.

2008-01-01

Clavicle is a unique bone for many reasons. There is no study discussing the differential diagnosis of clavicular lesions based on the site of occurrence or age at presentation. This study aims to determine whether the distribution of lesions affecting the clavicle and age at presentation aid in the differential diagnosis of focal clavicular lesions. Clinical notes, imaging and histopathological reports of the clavicular lesions between Jan 1999 and Jan 2006 were reviewed. Virtually, all patients had been referred as suspected neoplasm. Fifty-nine patients were identified. Patients 50 years (n=18) had predominantly malignant lesions. The lesions most commonly affected the medial third (n=35) and were predominantly non-neoplastic or benign. The middle third was affected in 15 patients and showed both benign and malignant lesions. The lateral third was least affected with predominance of malignant lesions. The clavicle is not a primary common site for any particular tumour; hence, diagnosis of the lesions can be challenging. Our study has suggested that few factors like age and site of the lesions may be helpful in diagnosis. (orig.)

Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study.

Science.gov (United States)

Sudha, M Ratna; Jayanthi, N; Aasin, M; Dhanashri, R D; Anirudh, T

2018-04-26

The efficacy of the probiotic strain, Bacillus coagulans Unique IS2 in the treatment of Irritable Bowel Syndrome (IBS) was evaluated in children. A total of 141 children of either sex in the age group 4-12 years, diagnosed with IBS according to the Rome III criteria, participated in the double-blind randomised controlled trial. Children received either B. coagulans Unique IS2 chewable tablets or placebo once daily for eight weeks followed by a two week follow-up period. Reduction in pain intensity as well as other symptoms associated with Irritable Bowel Syndrome like abdominal discomfort, bloating, distension, sense of incomplete evacuation, straining at stool, urgency of bowel movement, passage of gas and mucus, and bowel habit satisfaction were assessed. B. coagulans Unique IS2 treated group showed a greater reduction in pain scores as evaluated by a weekly pain intensity scale. There was a significant reduction (Pcoagulans Unique IS2 treated group as compared to the placebo group. This study demonstrates the efficacy of B. coagulans Unique IS2 in reducing the symptoms of Irritable Bowel Syndrome in children in the age group of 4-12 years.

Uniqueness of time-independent electromagnetic fields

DEFF Research Database (Denmark)

Karlsson, Per W.

1974-01-01

As a comment on a recent paper by Steele, a more general uniqueness theorem for time-independent fields is mentioned. ©1974 American Institute of Physics......As a comment on a recent paper by Steele, a more general uniqueness theorem for time-independent fields is mentioned. ©1974 American Institute of Physics...

Changes in unique hues induced by chromatic surrounds.

Science.gov (United States)

Klauke, Susanne; Wachtler, Thomas

2016-03-01

A chromatic surround can have a strong influence on the perceived hue of a stimulus. We investigated whether chromatic induction has similar effects on the perception of colors that appear pure and unmixed (unique red, green, blue, and yellow) as on other colors. Subjects performed unique hue settings of stimuli in isoluminant surrounds of different chromaticities. Compared with the settings in a neutral gray surround, unique hue settings altered systematically with chromatic surrounds. The amount of induced hue shift depended on the difference between stimulus and surround hues, and was similar for unique hue settings as for settings of nonunique hues. Intraindividual variability in unique hue settings was roughly twice as high as for settings obtained in asymmetric matching experiments, which may reflect the presence of a reference stimulus in the matching task. Variabilities were also larger with chromatic surrounds than with neutral gray surrounds, for both unique hue settings and matching of nonunique hues. The results suggest that the neural representations underlying unique hue percepts are influenced by the same neural processing mechanisms as the percepts of other colors.

Lehigh Design Course

Science.gov (United States)

Grassi, Vincent G.; Luyben, William L.; Silebi, Cesar A.

2011-01-01

This paper discusses a two-semester senior design course that combines traditional steady-state economic process design with dynamic plantwide control. This unique course has been taught at Lehigh for more than a decade and has garnered rave reviews from students, industry, and ABET. Each student design group has its own industrial consultant who…

Is Life Unique?

Science.gov (United States)

Abel, David L.

2011-01-01

Is life physicochemically unique? No. Is life unique? Yes. Life manifests innumerable formalisms that cannot be generated or explained by physicodynamics alone. Life pursues thousands of biofunctional goals, not the least of which is staying alive. Neither physicodynamics, nor evolution, pursue goals. Life is largely directed by linear digital programming and by the Prescriptive Information (PI) instantiated particularly into physicodynamically indeterminate nucleotide sequencing. Epigenomic controls only compound the sophistication of these formalisms. Life employs representationalism through the use of symbol systems. Life manifests autonomy, homeostasis far from equilibrium in the harshest of environments, positive and negative feedback mechanisms, prevention and correction of its own errors, and organization of its components into Sustained Functional Systems (SFS). Chance and necessity—heat agitation and the cause-and-effect determinism of nature’s orderliness—cannot spawn formalisms such as mathematics, language, symbol systems, coding, decoding, logic, organization (not to be confused with mere self-ordering), integration of circuits, computational success, and the pursuit of functionality. All of these characteristics of life are formal, not physical. PMID:25382119

Clinical Study of Bacillus coagulans Unique IS-2 (ATCC PTA-11748) in the Treatment of Patients with Bacterial Vaginosis.

Science.gov (United States)

Ratna Sudha, M; Yelikar, Kanan A; Deshpande, Sonali

2012-09-01

Bacterial vaginosis (BV) is the most prevalent vaginal infection worldwide and is characterized by reduction of native lactobacilli. Antimicrobial therapy used to cure the disease is often found to be ineffective. We postulate that Bacillus coagulans Unique IS-2 (Unique Biotech Limited, India) might provide an appendage to antimicrobial treatment and improve curing rate. In the present study 40 Indian women diagnosed with BV by the presence of symptoms including white discharge, pH greater than 4.7, burning micturation, itching, soreness and redness at vulva. The subjects were divided in 2 groups probiotic (n = 20) and control (n = 20) based on age (control group, 33 ± 3 years and probiotic group, 32.5 ± 3 years), history of previous vaginosis (control group, 75% or 15/20 and probiotic group, 75% or 15/20) and severity of current vaginosis infection (burning micturation and itching, 35% in each group). Probiotic group subjects were assigned to receive a dose of antibiotic therapy [Ofloxacin-Ornidazole with strength of 200-500 mg per capsule/day for 5 days along with vaginal peccaries (co-kimaxazol) for 3 days] simultaneously with two probiotic capsules (10(9) CFUs of Bacillus coagulans Unique IS-2 per capsule). The control group received only antibiotic therapy. At the end of the treatment the 80% of probiotic group subjects showed significant positive response as revealed by reduction of vaginosis symptoms compared to the control group which exhibited reduction in 45% subjects only. Thus, the results of present study indicate that strain Bacillus coagulans Unique IS-2 can provide benefits to women being treated with antibiotics to cure an infectious condition.

The radiologic technologists' health study in South Korea. Study design and baseline results

Energy Technology Data Exchange (ETDEWEB)

Lee, Won Jin [Korea Univ. College of Medicine, Seoul (Korea, Republic of). Dept. of Preventive Medicine; Ha, Mina [Dankook Univ. College of Medicine, Cheonan (Korea, Republic of). Dept. of Preventive Medicine; Hwang, Seung-sik [Inha Univ. School of Medicine, Incheon (Korea, Republic of). Dept. of Social and Preventive Medicine; and others

2015-08-15

To describe the study design, methods, and baseline results of a prospective cohort of radiologic technologists which we have initiated in South Korea. The cohort participants were enrolled through a self-administered questionnaire survey administered from April 2012 to May 2013. Survey data were linked with radiation dosimetry, a cancer registry, and health insurance data by personal identification numbers. A nationwide representative survey was also conducted using a stratified random sampling design with face-to-face interviews. A total of 12,387 radiologic technologists were enrolled, which accounted for approximately 63 % of all diagnostic radiologic technologists working in South Korea. For nationwide survey, 585 workers were interviewed using the detailed questionnaire, and buccal cells were also collected by scraping the inside of the cheek. The majority of study subjects were under 50-year-old and male workers. The average annual effective dose of radiation declined both men (from 2.75 to 1.43 mSv) and women (from 1.34 to 0.95 mSv) over the period of 1996-2011. A total of 99 cancers (66 cancers in men and 33 in women) were reported from 1992 to 2010. The standardized incidence ratio of all cancer combined was significantly lower in men (SIR = 0.75, 95 % CI 0.58-0.96) than general population, but the ratios for thyroid cancer were significantly higher than expected among both men and women. This cohort provides comprehensive information on work activities and health status of diagnostic radiologic technologists. In addition, the nationwide representative sample provides unique opportunities compared with previous radiologic technologist studies.

A Database Design and Development Case: NanoTEK Networks

Science.gov (United States)

Ballenger, Robert M.

2010-01-01

This case provides a real-world project-oriented case study for students enrolled in a management information systems, database management, or systems analysis and design course in which database design and development are taught. The case consists of a business scenario to provide background information and details of the unique operating…

Ultrasound comparison of external and internal neck anatomy with the LMA Unique.

Science.gov (United States)

Lee, Steven M; Wojtczak, Jacek A; Cattano, Davide

2017-12-01

Internal neck anatomy landmarks and their relation after placement of an extraglottic airway devices have not been studied extensively by the use of ultrasound. Based on our group experience with external landmarks as well as internal landmarks evaluation with other techniques, we aimed use ultrasound to analyze the internal neck anatomy landmarks and the related changes due to the placement of the Laryngeal Mask Airway Unique. Observational pilot investigation. Non-obese adult patients with no evidence of airway anomalies, were recruited. External neck landmarks were measured based on a validated and standardized method by tape. Eight internal anatomical landmarks, reciprocal by the investigational hypothesis to the external landmarks, were also measured by ultrasound guidance. The internal landmarks were re-measured after optimal placement and inflation of the extraglottic airway devices cuff Laryngeal Mask Airway Unique. Six subjects were recruited. Ultrasound measurements of hyoid-mental distance, thyroid-cricoid distance, thyroid height, and thyroid width were found to be significantly ( p internal neck anatomy. The induced changes and respective specific internal neck anatomy landmarks could help to design devices that would modify their shape accordingly to areas of greatest displacement. Also, while external neck landmark measurements overestimate their respective internal neck landmarks, as we previously reported, the concordance of each measurement and their respective conversion factor could continue to be of help in sizing extraglottic airway devices. Due to the pilot nature of the study, more investigations are warranted.

Unique proteomic signature for radiation sensitive patients; a comparative study between normo-sensitive and radiation sensitive breast cancer patients

Energy Technology Data Exchange (ETDEWEB)

Skiöld, Sara [Center for Radiation Protection Research, Department of Molecular Biosciences, The Wernner-Gren Institute, Stockholm University, Stockholm (Sweden); Azimzadeh, Omid [Institute of Radiation Biology, German Research Center for Environmental Health, Helmholtz Zentrum München (Germany); Merl-Pham, Juliane [Research Unit Protein Science, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg (Germany); Naslund, Ingemar; Wersall, Peter; Lidbrink, Elisabet [Division of Radiotherapy, Radiumhemmet, Karolinska University Hospital, Stockholm (Sweden); Tapio, Soile [Institute of Radiation Biology, German Research Center for Environmental Health, Helmholtz Zentrum München (Germany); Harms-Ringdahl, Mats [Center for Radiation Protection Research, Department of Molecular Biosciences, The Wernner-Gren Institute, Stockholm University, Stockholm (Sweden); Haghdoost, Siamak, E-mail: Siamak.Haghdoost@su.se [Center for Radiation Protection Research, Department of Molecular Biosciences, The Wernner-Gren Institute, Stockholm University, Stockholm (Sweden)

2015-06-15

Highlights: • The unique protein expression profiles were found that separate radiosensitive from normal sensitive breast cancer patients. • The oxidative stress response, coagulation properties and acute phase response suggested to be the hallmarks of radiation sensitivity. - Abstract: Radiation therapy is a cornerstone of modern cancer treatment. Understanding the mechanisms behind normal tissue sensitivity is essential in order to minimize adverse side effects and yet to prevent local cancer reoccurrence. The aim of this study was to identify biomarkers of radiation sensitivity to enable personalized cancer treatment. To investigate the mechanisms behind radiation sensitivity a pilot study was made where eight radiation-sensitive and nine normo-sensitive patients were selected from a cohort of 2914 breast cancer patients, based on acute tissue reactions after radiation therapy. Whole blood was sampled and irradiated in vitro with 0, 1, or 150 mGy followed by 3 h incubation at 37 °C. The leukocytes of the two groups were isolated, pooled and protein expression profiles were investigated using isotope-coded protein labeling method (ICPL). First, leukocytes from the in vitro irradiated whole blood from normo-sensitive and extremely sensitive patients were compared to the non-irradiated controls. To validate this first study a second ICPL analysis comparing only the non-irradiated samples was conducted. Both approaches showed unique proteomic signatures separating the two groups at the basal level and after doses of 1 and 150 mGy. Pathway analyses of both proteomic approaches suggest that oxidative stress response, coagulation properties and acute phase response are hallmarks of radiation sensitivity supporting our previous study on oxidative stress response. This investigation provides unique characteristics of radiation sensitivity essential for individualized radiation therapy.

Unique proteomic signature for radiation sensitive patients; a comparative study between normo-sensitive and radiation sensitive breast cancer patients

International Nuclear Information System (INIS)

Skiöld, Sara; Azimzadeh, Omid; Merl-Pham, Juliane; Naslund, Ingemar; Wersall, Peter; Lidbrink, Elisabet; Tapio, Soile; Harms-Ringdahl, Mats; Haghdoost, Siamak

2015-01-01

Highlights: • The unique protein expression profiles were found that separate radiosensitive from normal sensitive breast cancer patients. • The oxidative stress response, coagulation properties and acute phase response suggested to be the hallmarks of radiation sensitivity. - Abstract: Radiation therapy is a cornerstone of modern cancer treatment. Understanding the mechanisms behind normal tissue sensitivity is essential in order to minimize adverse side effects and yet to prevent local cancer reoccurrence. The aim of this study was to identify biomarkers of radiation sensitivity to enable personalized cancer treatment. To investigate the mechanisms behind radiation sensitivity a pilot study was made where eight radiation-sensitive and nine normo-sensitive patients were selected from a cohort of 2914 breast cancer patients, based on acute tissue reactions after radiation therapy. Whole blood was sampled and irradiated in vitro with 0, 1, or 150 mGy followed by 3 h incubation at 37 °C. The leukocytes of the two groups were isolated, pooled and protein expression profiles were investigated using isotope-coded protein labeling method (ICPL). First, leukocytes from the in vitro irradiated whole blood from normo-sensitive and extremely sensitive patients were compared to the non-irradiated controls. To validate this first study a second ICPL analysis comparing only the non-irradiated samples was conducted. Both approaches showed unique proteomic signatures separating the two groups at the basal level and after doses of 1 and 150 mGy. Pathway analyses of both proteomic approaches suggest that oxidative stress response, coagulation properties and acute phase response are hallmarks of radiation sensitivity supporting our previous study on oxidative stress response. This investigation provides unique characteristics of radiation sensitivity essential for individualized radiation therapy

Revealing a steroid receptor ligand as a unique PPAR[gamma] agonist

Energy Technology Data Exchange (ETDEWEB)

Lin, Shengchen; Han, Ying; Shi, Yuzhe; Rong, Hui; Zheng, Songyang; Jin, Shikan; Lin, Shu-Yong; Lin, Sheng-Cai; Li, Yong (Pitt); (Xiamen)

2012-06-28

Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) regulates metabolic homeostasis and is a molecular target for anti-diabetic drugs. We report here the identification of a steroid receptor ligand, RU-486, as an unexpected PPAR{gamma} agonist, thereby uncovering a novel signaling route for this steroid drug. Similar to rosiglitazone, RU-486 modulates the expression of key PPAR{gamma} target genes and promotes adipocyte differentiation, but with a lower adipogenic activity. Structural and functional studies of receptor-ligand interactions reveal the molecular basis for a unique binding mode for RU-486 in the PPAR{gamma} ligand-binding pocket with distinctive properties and epitopes, providing the molecular mechanisms for the discrimination of RU-486 from thiazolidinediones (TZDs) drugs. Our findings together indicate that steroid compounds may represent an alternative approach for designing non-TZD PPAR{gamma} ligands in the treatment of insulin resistance.

Coexistence of uniquely ergodic subsystems of interval mapping

International Nuclear Information System (INIS)

Ye Xiangdong.

1991-10-01

The purpose of this paper is to show that uniquely ergodic subsystems of interval mapping also coexist in the same way as minimal sets do. To do this we give some notations in section 2. In section 3 we define D-function of a uniquely ergodic system and show its basic properties. We prove the coexistence of uniquely ergodic subsystems of interval mapping in section 4. Lastly we give the examples of uniquely ergodic systems with given D-functions in section 5. 27 refs

Electroplating targets for production of unique PET radionuclides

International Nuclear Information System (INIS)

Bui, V.; Sheh, Y.; Finn, R.

1994-01-01

The past decade has witnessed the applications of Positron Emission Tomography (PET) evolving from a purely research endeavour to a procedure which has specific clinical applications in the areas of cardiology, neurology and oncology. The growth of PET has been facilitated by developments in medical instrumentation and radiopharmaceutical chemistry efforts. Included in this latter effort has been the low energy accelerator production and processing of unique PET radionuclides appropriate for the radiolabeling of biomolecules i.e. monoclonal antibodies and pepetides. The development and application of electroplated targets of antimony and copper for the production of iodine-124 and gallium-66 respectively, utilizing the Memorial Sloan-Kettering Cancer Center cyclotron are examples of target design and development applicable to many medical accelerators

A Unique Opportunity for an Intercultural Discussion on CAM and Liver Disease

Directory of Open Access Journals (Sweden)

Francesco Marotta

2005-01-01

Full Text Available The meeting of the APASL, Asian Pacific Association for the Study of the Liver, was held in December 2004, in New Delhi, India. The meeting was held under the patronage of the APASL Committee and Board of Presidents of the National Liver Association and in conjunction with the annual conference of the Indian Association for the Study of Liver (INASL. The congress was designed to have a core meeting with three parallel sessions running throughout, dedicated research workshops and intensive breakfast sessions. This report concentrates on the two sessions devoted to complementary and alternative medicine (CAM and shows the latest research in CAM for liver disease and the concerns of doctors about integrating CAM with more traditional treatments. With researchers and practitioners gathering from all over the world, it was a unique opportunity for an intercultural discussion on CAM and liver disease.

Non-unique Product Groups on Two Generators

OpenAIRE

Carter, William Paul

2007-01-01

The main purpose of this paper is to better understand groups that do not have the unique product property. In particular, the goal is to better understand Promislow's example, G, of such a group. In doing so, we will develop methods for generating examples of other sets that do not have the unique product property. With these methods we can show that there exists other distinct 14 element, square, non-unique product sets in G that are not inversions or translations. Also, this paper answers ...

Re-Design Interior Boutique Hotel Di Malang

OpenAIRE

Mariana Wibowo, Inez Natalia Suteja

2016-01-01

Malang is one of the places nostalgia tourists by Dutchman. Design boutique hotel take building's dutch colonial. Boutique hotel having the characteristics of unique, historic, and fancy. Uniqueness boutique hotel ditonjolkan in the atmosphere hotel that looks homey with support 3star class hotel facilities. The concept of the basis of design with apply a style of design colonial into the interior of boutique hotel good with the material the wall, the floor, ceiling, column and the elements d...

Fusion Engineering Device. Volume II. Design description

International Nuclear Information System (INIS)

1981-10-01

This volume summarizes the design of the FED. It includes a description of the major systems and subsystems, the supporting plasma design analysis, a projected device cost and associated construction schedule, and a description of the facilities to house and support the device. This effort represents the culmination of the FY81 studies conducted at the Fusion Engineering Design Center (FEDC). Unique in these design activities has been the collaborative involvement of the Design Center personnel and numerous resource physicists from the fusion community who have made significant contributions in the physics design analysis as well as the physics support of the engineering design of the major FED systems and components

Executive Functions Contribute Uniquely to Reading Competence in Minority Youth

Science.gov (United States)

Jacobson, Lisa A.; Koriakin, Taylor; Lipkin, Paul; Boada, Richard; Frijters, Jan; Lovett, Maureen; Hill, Dina; Willcutt, Erik; Gottwald, Stephanie; Wolf, Maryanne; Bosson-Heenan, Joan; Gruen, Jeffrey R.; Mahone, E. Mark

2018-01-01

Competent reading requires various skills beyond those for basic word reading (i.e., core language skills, rapid naming, phonological processing). Contributing “higher-level” or domain-general processes include information processing speed and executive functions (working memory, strategic problem solving, attentional switching). Research in this area has relied on largely Caucasian samples, with limited representation of children from racial or ethnic minority groups. This study examined contributions of executive skills to reading competence in 761 children of minority backgrounds. Hierarchical linear regressions examined unique contributions of executive functions (EF) to word reading, fluency, and comprehension. EF contributed uniquely to reading performance, over and above reading-related language skills; working memory contributed uniquely to all components of reading; while attentional switching, but not problem solving, contributed to isolated and contextual word reading and reading fluency. Problem solving uniquely predicted comprehension, suggesting that this skill may be especially important for reading comprehension in minority youth. Attentional switching may play a unique role in development of reading fluency in minority youth, perhaps as a result of the increased demand for switching between spoken versus written dialects. Findings have implications for educational and clinical practice with regard to reading instruction, remedial reading intervention, and assessment of individuals with reading difficulty. PMID:26755569

Basic design in architectural education in Turkey

Directory of Open Access Journals (Sweden)

Makaklı Elif Süyük

2016-01-01

Full Text Available Creative activity is one of the most significant parts of architectural education. In the architectural curriculum organisation ‘design studio’ is the unique and preeminent subject. Freshman students encounter ‘design’ first in basic design course, before they know what designing incorporates. The Basic Design is the starting point of initiating creativity in architecture education. It helps each student to understand architecture as a creative and innovative practice in the first year of education. This study analyzes the characteristics of basic design course, the topics of the course contents and its significance in the architectural curriculum in Turkey as well.

Cone photoreceptor sensitivities and unique hue chromatic responses: correlation and causation imply the physiological basis of unique hues.

Science.gov (United States)

Pridmore, Ralph W

2013-01-01

This paper relates major functions at the start and end of the color vision process. The process starts with three cone photoreceptors transducing light into electrical responses. Cone sensitivities were once expected to be Red Green Blue color matching functions (to mix colors) but microspectrometry proved otherwise: they instead peak in yellowish, greenish, and blueish hues. These physiological functions are an enigma, unmatched with any set of psychophysical (behavioral) functions. The end-result of the visual process is color sensation, whose essential percepts are unique (or pure) hues red, yellow, green, blue. Unique hues cannot be described by other hues, but can describe all other hues, e.g., that hue is reddish-blue. They are carried by four opponent chromatic response curves but the literature does not specify whether each curve represents a range of hues or only one hue (a unique) over its wavelength range. Here the latter is demonstrated, confirming that opponent chromatic responses define, and may be termed, unique hue chromatic responses. These psychophysical functions also are an enigma, unmatched with any physiological functions or basis. Here both enigmas are solved by demonstrating the three cone sensitivity curves and the three spectral chromatic response curves are almost identical sets (Pearson correlation coefficients r from 0.95-1.0) in peak wavelengths, curve shapes, math functions, and curve crossover wavelengths, though previously unrecognized due to presentation of curves in different formats, e.g., log, linear. (Red chromatic response curve is largely nonspectral and thus derives from two cones.) Close correlation combined with deterministic causation implies cones are the physiological basis of unique hues. This match of three physiological and three psychophysical functions is unique in color vision.

Vehicle systems design optimization study

Energy Technology Data Exchange (ETDEWEB)

Gilmour, J. L.

1980-04-01

The optimization of an electric vehicle layout requires a weight distribution in the range of 53/47 to 62/38 in order to assure dynamic handling characteristics comparable to current production internal combustion engine vehicles. It is possible to achieve this goal and also provide passenger and cargo space comparable to a selected current production sub-compact car either in a unique new design or by utilizing the production vehicle as a base. Necessary modification of the base vehicle can be accomplished without major modification of the structure or running gear. As long as batteries are as heavy and require as much space as they currently do, they must be divided into two packages - one at front under the hood and a second at the rear under the cargo area - in order to achieve the desired weight distribution. The weight distribution criteria requires the placement of batteries at the front of the vehicle even when the central tunnel is used for the location of some batteries. The optimum layout has a front motor and front wheel drive. This configuration provides the optimum vehicle dynamic handling characteristics and the maximum passsenger and cargo space for a given size vehicle.

Recycler ring conceptual design study

International Nuclear Information System (INIS)

Jackson, G.

1995-01-01

The Tevatron Collider provides the highest center of mass energy collisions in the world. To fully exploit this unique tool, Fermilab is committed to a program of accelerator upgrades for the purpose of increasing the Collider luminosity. Over the past 7 years the luminosity has been increased from a peak of 1.6x10 30 cm -2 sec -1 in 1989 to over 3x10 31 cm -2 sec -1 during 1995. The Main Injector will supply a larger flux of protons for antiproton production and more intense proton bunches for use in the Collider, and this is expected to increase the peak luminosity to close to 1x10 32 cm -2 sec -1 . Further increases in luminosity will require additional upgrades to the Fermilab accelerator complex. This report documents the design of a new fixed-energy storage ring to be placed in the Main Injector tunnel which will provide an initial factor of 2 increase to 2x10 32 cm -2 sec -1 , and ultimately provide the basis for an additional order of magnitude luminosity increase up to 1x10 33 cm -2 sec -1

Investigation of unique hue setting changes with ageing

Institute of Scientific and Technical Information of China (English)

Chenyang Fu; Kaida Xiao; Dimosthenis Karatzas; Sophie Wuerger

2011-01-01

Clromatic sensitivity along the protan, deutan, and tritan lines and the loci of the unique hues (red, green,yellow, blue) for a very large sample (n = 185) of colour-normal observers ranging from 18 to 75 years of age are assessed. Visual judgments are obtained under normal viewing conditions using colour patches on self-luminous display under controlled adaptation conditions. Trivector discrimination thresholds show an increase as a function of age along the protan, deutan, and tritan axes, with the largest increase present along the tritan line, less pronounced shifts in unique hue settings are also observed. Based on the chromatic (protan, deutan, tritan) thresholds and using scaled cone signals, we predict the unique hue changes with ageing. A dependency on age for unique red and unique yellow for predicted hue angle is found. We conclude that the chromatic sensitivity deteriorates significantly with age, whereas the appearance of unique hues is much less affected, remaining almost constant despite the known changes in the ocular media.%@@ Clromatic sensitivity along the protan, deutan, and tritan lines and the loci of the unique hues (red, green,yellow, blue) for a very large sample (n ＝ 185) of colour-normal observers ranging from 18 to 75 years of age are assessed.Visual judgments are obtained under normal viewing conditions using colour patches on self-luminous display under controlled adaptation conditions.Trivector discrimination thresholds show an increase as a function of age along the protan, deutan, and tritan axes, with the largest increase present along the tritan line, less pronounced shifts in unique hue settings are also observed.

SWOT analysis of program design and implementation: a case study on the reduction of maternal mortality in Afghanistan.

Science.gov (United States)

Ahmadi, Qudratullah; Danesh, Homayoon; Makharashvili, Vasil; Mishkin, Kathryn; Mupfukura, Lovemore; Teed, Hillary; Huff-Rousselle, Maggie

2016-07-01

This case study analyzes the design and implementation of the Basic Package of Health Services (BPHS) in Afghanistan by synthesizing the literature with a focus on maternal health services. The authors are a group of graduate students in the Brandeis University International Health Policy and Management Program and Sustainable International Development Program who used the experience in Afghanistan to analyze an example of successfully implementing policy; two of the authors are Afghan physicians with direct experience in implementing the BPHS. Data is drawn from a literature review, and a unique aspect of the case study is the application of the business-oriented SWOT analysis to the design and implementation of the program that successfully targeted lowering maternal mortality in Afghanistan. It provides a useful example of how SWOT analysis can be used to consider the reasons for, or likelihood of, successful or unsuccessful design and implementation of a policy or program. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Design in Four Diagnostic Language Assessments

Science.gov (United States)

Cumming, Alister

2015-01-01

The studies documented in the four articles in this special issue uniquely exemplify principles of design-based research as follows: by taking innovative approaches to significant problems in the contexts of real educational practices; by addressing fundamental pedagogical and policy issues related to language, learning, and teaching; and, in the…

Differentiating Performance Approach Goals and Their Unique Effects

Science.gov (United States)

Edwards, Ordene V.

2014-01-01

The study differentiates between two types of performance approach goals (competence demonstration performance approach goal and normative performance approach goal) by examining their unique effects on self-efficacy, interest, and fear of failure. Seventy-nine students completed questionnaires that measure performance approach goals,…

The unique rht-MOF platform, ideal for pinpointing the functionalization and CO 2 adsorption relationship

KAUST Repository

Luebke, Ryan

2012-01-01

The uniqueness of the rht-MOF platform, based on the singular (3,24)-connected net, allows for the facile design and synthesis of functionalized materials for desired applications. Here we designed a nitrogen-rich trefoil hexacarboxylate (trigonal tri-isophthalate) ligand, which serves to act as the trigonal molecular building block while concurrently coding the formation of the targeted truncated cuboctahedral supermolecular building block (in situ), and enhancing the CO 2 uptake in the resultant rht-MOF. © 2012 The Royal Society of Chemistry.

Sustainable design guidelines to support the Washington State ferries terminal design manual : stormwater and material issues.

Science.gov (United States)

2011-08-01

In an effort to assist the developers of the terminal design manual in potentially addressing : sustainable design issues, the overall goal is to produce Sustainable Design Guidelines that : will specifically address the unique needs and requirements...

Modularity, comparative cognition and human uniqueness

OpenAIRE

Shettleworth, Sara J.

2012-01-01

Darwin's claim ‘that the difference in mind between man and the higher animals … is certainly one of degree and not of kind’ is at the core of the comparative study of cognition. Recent research provides unprecedented support for Darwin's claim as well as new reasons to question it, stimulating new theories of human cognitive uniqueness. This article compares and evaluates approaches to such theories. Some prominent theories propose sweeping domain-general characterizations of the difference ...

Word from the CSO - CERN’s unique scientific breadth

CERN Multimedia

2008-01-01

Whilst we are all clearly focused on completion of the LHC and the detectors around it and look forward to a successful start of operations later this year, we should not forget that CERN has yet more to offer in addition to this highest priority programme ‘at the energy frontier’. Indeed, CERN also attracts a large scientific community seizing the opportunities offered by its other facilities. Sometimes I wonder whether we are not too modest and should not emphasize more CERN’s unique scientific breadth. ISOLDE, at the PS Booster, relies on innovative techniques to produce results at the forefront of nuclear physics very cost-effectively. nTOF has provided unique measurements of interest to nuclear technology, nuclear astrophysics and basic nuclear physics, and still has an ambitious programme ahead of it after refurbishment of the target. Another unique facility is the Antiproton Decelerator, at which the study of antimatter is being pursued with ingenious experiment...

Accelerator-based conversion (ABC) of weapons plutonium: Plant layout study and related design issues

International Nuclear Information System (INIS)

Cowell, B.S.; Fontana, M.H.; Krakowski, R.A.; Beard, C.A.; Buksa, J.J.; Davidson, J.W.; Sailor, W.C.; Williamson, M.A.

1995-01-01

In preparation for and in support of a detailed R and D Plan for the Accelerator-Based Conversion (ABC) of weapons plutonium, an ABC Plant Layout Study was conducted at the level of a pre-conceptual engineering design. The plant layout is based on an adaptation of the Molten-Salt Breeder Reactor (MSBR) detailed conceptual design that was completed in the early 1070s. Although the ABC Plant Layout Study included the Accelerator Equipment as an essential element, the engineering assessment focused primarily on the Target; Primary System (blanket and all systems containing plutonium-bearing fuel salt); the Heat-Removal System (secondary-coolant-salt and supercritical-steam systems); Chemical Processing; Operation and Maintenance; Containment and Safety; and Instrumentation and Control systems. Although constrained primarily to a reflection of an accelerator-driven (subcritical) variant of MSBR system, unique features and added flexibilities of the ABC suggest improved or alternative approaches to each of the above-listed subsystems; these, along with the key technical issues in need of resolution through a detailed R ampersand D plan for ABC are described on the bases of the ''strawman'' or ''point-of-departure'' plant layout that resulted from this study

Designing with precedents

NARCIS (Netherlands)

Pasman, G.

2003-01-01

Every year designers are challenged to generate new and unique product forms. Often, the design and form of previous products constitutes a basis for the generation of new ones. What role then do existing products play in the generation and development of new product forms? How can this role be

Why Is Family Firms' Internationalization Unique? : A Meta-Analysis

NARCIS (Netherlands)

Arregle, Jean-Luc; Duran, Patricio; Hitt, Michael A.; van Essen, M.

Despite its importance, there is no clear understanding of the uniqueness of family firms' internationalization. This article sheds new light on this issue with a meta-analysis of 76 studies covering 41 countries. We show that the considerable study and cross-country differences in the relationship

Uniqueness conditions for finitely dependent random fields

International Nuclear Information System (INIS)

Dobrushin, R.L.; Pecherski, E.A.

1981-01-01

The authors consider a random field for which uniqueness and some additional conditions guaranteeing that the correlations between the variables of the field decrease rapidly enough with the distance between the values of the parameter occur. The main result of the paper states that in such a case uniqueness is true for any other field with transition probabilities sufficiently close to those of the original field. Then they apply this result to some ''degenerate'' classes of random fields for which one can check this condition of correlation to decay, and thus obtain some new conditions of uniqueness. (Auth.)

Cone photoreceptor sensitivities and unique hue chromatic responses: correlation and causation imply the physiological basis of unique hues.

Directory of Open Access Journals (Sweden)

Ralph W Pridmore

Full Text Available This paper relates major functions at the start and end of the color vision process. The process starts with three cone photoreceptors transducing light into electrical responses. Cone sensitivities were once expected to be Red Green Blue color matching functions (to mix colors but microspectrometry proved otherwise: they instead peak in yellowish, greenish, and blueish hues. These physiological functions are an enigma, unmatched with any set of psychophysical (behavioral functions. The end-result of the visual process is color sensation, whose essential percepts are unique (or pure hues red, yellow, green, blue. Unique hues cannot be described by other hues, but can describe all other hues, e.g., that hue is reddish-blue. They are carried by four opponent chromatic response curves but the literature does not specify whether each curve represents a range of hues or only one hue (a unique over its wavelength range. Here the latter is demonstrated, confirming that opponent chromatic responses define, and may be termed, unique hue chromatic responses. These psychophysical functions also are an enigma, unmatched with any physiological functions or basis. Here both enigmas are solved by demonstrating the three cone sensitivity curves and the three spectral chromatic response curves are almost identical sets (Pearson correlation coefficients r from 0.95-1.0 in peak wavelengths, curve shapes, math functions, and curve crossover wavelengths, though previously unrecognized due to presentation of curves in different formats, e.g., log, linear. (Red chromatic response curve is largely nonspectral and thus derives from two cones. Close correlation combined with deterministic causation implies cones are the physiological basis of unique hues. This match of three physiological and three psychophysical functions is unique in color vision.

Practical relevance of pattern uniqueness in forensic science.

Science.gov (United States)

Jayaprakash, Paul T

2013-09-10

Uniqueness being unprovable, it has recently been argued that individualization in forensic science is irrelevant and, probability, as applied for DNA profiles, should be applied for all identifications. Critiques against uniqueness have omitted physical matching, a realistic and tangible individualization that supports uniqueness. Describing case examples illustrating pattern matches including physical matching, it is indicated that individualizations are practically relevant for forensic science as they establish facts on a definitive basis providing firm leads benefitting criminal investigation. As a tenet of forensic identification, uniqueness forms a fundamental paradigm relevant for individualization. Evidence on the indeterministic and stochastic causal pathways of characteristics in patterns available in the related fields of science sufficiently supports the proposition of uniqueness. Characteristics involved in physical matching and matching achieved in patterned evidence existing in the state of nature are not events amenable for counting; instead these are ensemble of visible units occupying the entire pattern area stretching the probability of re-occurrence of a verisimilitude pattern into infinity offering epistemic support to uniqueness. Observational methods are as respectable as instrumental or statistical methods since they are capable of generating results that are tangible and obviously valid as in physical matching. Applying the probabilistic interpretation used for DNA profiles to the other patterns would be unbefitting since these two are disparate, the causal pathways of the events, the loci, in the manipulated DNA profiles being determinable. While uniqueness enables individualizations, it does not vouch for eliminating errors. Instead of dismissing uniqueness and individualization, accepting errors as human or system failures and seeking remedial measures would benefit forensic science practice and criminal investigation. Copyright © 2013

TDRSS S-shuttle unique receiver equipment

Science.gov (United States)

Weinberg, A.; Schwartz, J. J.; Spearing, R.

1985-01-01

Beginning with STS-9, the Tracking and Date Relay Satellite system (TDRSS) will start providing S- and Ku-band communications and tracking support to the Space Shuttle and its payloads. The most significant element of this support takes place at the TDRSS White Sands Ground Terminal, which processes the Shuttle return link S- and Ku-band signals. While Ku-band hardware available to other TDRSS users is also applied to Ku-Shuttle, stringent S-Shuttle link margins have precluded the application of the standard TDRSS S-band processing equipment to S-Shuttle. It was therfore found necessary to develop a unique S-Shuttle Receiver that embodies state-of-the-art digital technology and processing techniques. This receiver, developed by Motorola, Inc., enhances link margins by 1.5 dB relative to the standard S-band equipment and its bit error rate performance is within a few tenths of a dB of theory. An overview description of the Space Shuttle Receiver Equipment (SSRE) is presented which includes the presentation of block diagrams and salient design features. Selected, measured performance results are also presented.

Analysis of Combined Data from Heterogeneous Study Designs: A Methodological Proposal from the Patient Navigation Research program

Science.gov (United States)

Roetzheim, Richard G.; Freund, Karen M.; Corle, Don K.; Murray, David M.; Snyder, Frederick R.; Kronman, Andrea C.; Jean-Pierre, Pascal; Raich, Peter C.; Holden, Alan E. C.; Darnell, Julie S.; Warren-Mears, Victoria; Patierno, Steven; Design, PNRP; Committee, Analysis

2013-01-01

Background The Patient Navigation Research Program (PNRP) is a cooperative effort of nine research projects, each employing its own unique study design. To evaluate projects such as PNRP, it is desirable to perform a pooled analysis to increase power relative to the individual projects. There is no agreed upon prospective methodology, however, for analyzing combined data arising from different study designs. Expert opinions were thus solicited from members of the PNRP Design and Analysis Committee Purpose To review possible methodologies for analyzing combined data arising from heterogeneous study designs. Methods The Design and Analysis Committee critically reviewed the pros and cons of five potential methods for analyzing combined PNRP project data. Conclusions were based on simple consensus. The five approaches reviewed included: 1) Analyzing and reporting each project separately, 2) Combining data from all projects and performing an individual-level analysis, 3) Pooling data from projects having similar study designs, 4) Analyzing pooled data using a prospective meta analytic technique, 5) Analyzing pooled data utilizing a novel simulated group randomized design. Results Methodologies varied in their ability to incorporate data from all PNRP projects, to appropriately account for differing study designs, and in their impact from differing project sample sizes. Limitations The conclusions reached were based on expert opinion and not derived from actual analyses performed. Conclusions The ability to analyze pooled data arising from differing study designs may provide pertinent information to inform programmatic, budgetary, and policy perspectives. Multi-site community-based research may not lend itself well to the more stringent explanatory and pragmatic standards of a randomized controlled trial design. Given our growing interest in community-based population research, the challenges inherent in the analysis of heterogeneous study design are likely to become

Safety design

International Nuclear Information System (INIS)

Kunitomi, Kazuhiko; Shiozawa, Shusaku

2004-01-01

JAERI established the safety design philosophy of the HTTR based on that of current reactors such as LWR in Japan, considering inherent safety features of the HTTR. The strategy of defense in depth was implemented so that the safety engineering functions such as control of reactivity, removal of residual heat and confinement of fission products shall be well performed to ensure safety. However, unlike the LWR, the inherent design features of the high-temperature gas-cooled reactor (HTGR) enables the HTTR meet stringent regulatory criteria without much dependence on active safety systems. On the other hand, the safety in an accident typical to the HTGR such as the depressurization accident initiated by a primary pipe rupture shall be ensured. The safety design philosophy of the HTTR considers these unique features appropriately and is expected to be the basis for future Japanese HTGRs. This paper describes the safety design philosophy and safety evaluation procedure of the HTTR especially focusing on unique considerations to the HTTR. Also, experiences obtained from an HTTR safety review and R and D needs for establishing the safety philosophy for the future HTGRs are reported

Target Choice and Unique Synergies in Global Mobile Telephony

DEFF Research Database (Denmark)

Claussen, Jörg; Köhler, Rebecca; Kretschmer, Tobias

2018-01-01

their foresight to select specific targets: First, they lower integration costs by selecting geographically close targets. This effect is stronger when buyer and target are in the same country, but only if the market is not so concentrated that it provokes regulatory interventions. Second, they select targets......The success of acquisitions rests on detecting and realizing unique synergies between buyer and target through their dyadic relationships. We study the role of unique dyad-specific synergies in the selection of takeover targets in the global mobile telecommunications industry. Firms use...... that can be acquired at a modest bid premium because they have asymmetric bargaining power. Finally, they select targets which can generate significant synergies due to technological synergies. Our work expands the existing target selection literature by studying dyad-specific factors within a single...

The design of the MOONS-VLT spectrometer

NARCIS (Netherlands)

Oliva, E.; Diolaiti, E.; Garilli, B.; Gratton, R.; Lorenzetti, D.; Schipani, P.; Scuderi, S.; Vanzella, E.; Cirasuolo, M.; Afonso, J.; Bender, R.; Bonifacio, P.; Kaper, L.; Vanzi, L.; Baffa, C.; Bianco, A.; Bonoli, C.; Bortoletto, F.; Bruno, P.; Carbonaro, L.; Centrone, M.; Cresci, G.; De Caprio, V.; Del Vecchio, C.; Di Marcantonio, P.; Di Paola, A.; D'Alessio, F.; D'Alessandro, M.; D'Orsi, S.; Falcini, G.; Ferruzzi, D.; Fontana, A.; Foppiani, I.; Fumana, M.; Giani, E.; Leone, F.; Li Causi, G.; Lombini, M.; Maiolino, R.; Mannucci, F.; Marty, L.; Miglietta, L.; Munari, M.; Navarro, R.; Origlia, L.; Paioro, L.; Pedichini, F.; Pragt, J.; Randich, S.; Scodeggio, M.; Spano, P.; Speziali, R.; Stuik, R.; Tozzi, A.; Vitali, F.

2012-01-01

MOONS is a new conceptual design for a multi-object spectrograph for the ESO Very Large Telescope (VLT) which will provide the ESO astronomical community with a powerful, unique instrument able to serve a wide range of Galactic, Extragalactic and Cosmological studies. The instrument foresees 1000

Parental Expressivity and Parenting Styles in Chinese Families: Prospective and Unique Relations to Children’s Psychological Adjustment

Science.gov (United States)

Chen, Stephen H.; Zhou, Qing; Eisenberg, Nancy; Valiente, Carlos; Wang, Yun

2012-01-01

SYNOPSIS Objectives Parents from different cultures differ in how frequently they express emotions. However, the generalizability of the relations between parental expressivity and child adjustment in non-Western cultures has not been extensively studied. The goal of the present study was to investigate prospective relations between parental expressivity within the family (positive, negative dominant, and negative submissive expressivity) and Chinese children’s psychological adjustment, above and beyond parenting styles. Design The study used two waves (3.8 years apart) of longitudinal data from a sample (n= 425) of children in Beijing (mean ages = 7.7 years at T1 and 11.6 years at T2). Parental expressivity and parenting styles were self-reported. To reduce the potential measurement overlap, items that tap parental expression of emotions toward the child were removed from the parenting style measure. Children’s adjustment was measured with parents’, teachers’, and peers’ or children’s reports. Results Consistent with findings with European American samples, parental negative dominant expressivity uniquely and positively predicted Chinese children’s externalizing problems controlling for prior externalizing problems, parenting styles, and family SES. Neither parental expressivity nor parenting styles uniquely predicted social competence. Conclusions Despite previously reported cultural differences in the mean levels of parental expressivity, some of the socialization functions of parental expressivity found in Western countries can be generalized to Chinese families. Although parental expressivity and parenting styles are related constructs, their unique relations to child’s adjustment suggest that they should be examined as distinct processes. PMID:23226715

The Role of Visual Working Memory in Attentive Tracking of Unique Objects

Science.gov (United States)

Makovski, Tal; Jiang, Yuhong V.

2009-01-01

When tracking moving objects in space humans usually attend to the objects' spatial locations and update this information over time. To what extent do surface features assist attentive tracking? In this study we asked participants to track identical or uniquely colored objects. Tracking was enhanced when objects were unique in color. The benefit…

Human uniqueness-self-interest and social cooperation.

Science.gov (United States)

Okada, Daijiro; Bingham, Paul M

2008-07-21

Humans are unique among all species of terrestrial history in both ecological dominance and individual properties. Many, or perhaps all, of the unique elements of this nonpareil status can be plausibly interpreted as evolutionary and strategic elements and consequences of the unprecedented intensity and scale of our social cooperation. Convincing explanation of this unique human social adaptation remains a central, unmet challenge to the scientific enterprise. We develop a hypothesis for the ancestral origin of expanded cooperative social behavior. Specifically, we present a game theoretic analysis demonstrating that a specific pattern of expanded social cooperation between conspecific individuals with conflicts of interest (including non-kin) can be strategically viable, but only in animals that possess a highly unusual capacity for conspecific violence (credible threat) having very specific properties that dramatically reduce the costs of coercive violence. The resulting reduced costs allow preemptive or compensated coercion to be an instantaneously self-interested behavior under diverse circumstances rather than in rare, idiosyncratic circumstances as in actors (animals) who do not have access to inexpensive coercive threat. Humans are apparently unique among terrestrial organisms in having evolved conspecific coercive capabilities that fulfill these stringent requirements. Thus, our results support the proposal that access to a novel capacity for projection of coercive threat might represent the essential initiating event for the evolution of a human-like pattern of social cooperation and the subsequent evolution of the diverse features of human uniqueness. Empirical evidence indicates that these constraints were, in fact, met only in our evolutionary lineage. The logic for the emergence of uniquely human cooperation suggested by our analysis apparently accounts simply for the human fossil record.

Constructing Dense Graphs with Unique Hamiltonian Cycles

Science.gov (United States)

Lynch, Mark A. M.

2012-01-01

It is not difficult to construct dense graphs containing Hamiltonian cycles, but it is difficult to generate dense graphs that are guaranteed to contain a unique Hamiltonian cycle. This article presents an algorithm for generating arbitrarily large simple graphs containing "unique" Hamiltonian cycles. These graphs can be turned into dense graphs…

Uniqueness of flat spherically symmetric spacelike hypersurfaces admitted by spherically symmetric static spacetimes

Science.gov (United States)

Beig, Robert; Siddiqui, Azad A.

2007-11-01

It is known that spherically symmetric static spacetimes admit a foliation by flat hypersurfaces. Such foliations have explicitly been constructed for some spacetimes, using different approaches, but none of them have proved or even discussed the uniqueness of these foliations. The issue of uniqueness becomes more important due to suitability of flat foliations for studying black hole physics. Here, flat spherically symmetric spacelike hypersurfaces are obtained by a direct method. It is found that spherically symmetric static spacetimes admit flat spherically symmetric hypersurfaces, and that these hypersurfaces are unique up to translation under the timelike Killing vector. This result guarantees the uniqueness of flat spherically symmetric foliations for such spacetimes.

Scientific Support of Construction of Unique Buildings and Structures and Facilities of Increased Danger

Science.gov (United States)

Alekhin, V. N.; Antipin, A. A.; Gorodilov, S. N.

2017-11-01

A range of works on scientific support for the construction of unique buildings and the structures and facilities of increased danger, such as airport facilities, long-span and high-rise buildings is being implemented at the department “Computer Aided Design in Civil Engineering” of Ural Federal University. The scope of work includes: numerical simulation of wind and snow loads, analysis of progressive collapse and seismic impacts, verification of design solutions. The results of wind, snow loads and progressive collapse of airport buildings in the cities of Orenburg, Rostov-on-Don and Perm are considered in the article.

Design of a Randomized Controlled Trial for Ebola Virus Disease Medical Countermeasures: PREVAIL II, the Ebola MCM Study.

Science.gov (United States)

Dodd, Lori E; Proschan, Michael A; Neuhaus, Jacqueline; Koopmeiners, Joseph S; Neaton, James; Beigel, John D; Barrett, Kevin; Lane, Henry Clifford; Davey, Richard T

2016-06-15

Unique challenges posed by emerging infectious diseases often expose inadequacies in the conventional phased investigational therapeutic development paradigm. The recent Ebola outbreak in West Africa presents a critical case-study highlighting barriers to faster development. During the outbreak, clinical trials were implemented with unprecedented speed. Yet, in most cases, this fast-tracked approach proved too slow for the rapidly evolving epidemic. Controversy abounded as to the most appropriate study designs to yield safety and efficacy data, potentially causing delays in pivotal studies. Preparation for research during future outbreaks may require acceptance of a paradigm that circumvents, accelerates, or reorders traditional phases, without losing sight of the traditional benchmarks by which drug candidates must be assessed for activity, safety and efficacy. We present the design of an adaptive, parent protocol, ongoing in West Africa until January 2016. The exigent circumstances of the outbreak and limited prior clinical experience with experimental treatments, led to more direct bridging from preclinical studies to human trials than the conventional paradigm would typically have sanctioned, and required considerable design flexibility. Preliminary evaluation of the "barely Bayesian" design was provided through computer simulation studies. The understanding and public discussion of the study design will help its future implementation. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

A Numerical Study of Anti-Vortex Film Cooling Designs at High Blowing Ratio

Science.gov (United States)

Heidmann, James D.

2008-01-01

A concept for mitigating the adverse effects of jet vorticity and liftoff at high blowing ratios for turbine film cooling flows has been developed and studied at NASA Glenn Research Center. This "anti-vortex" film cooling concept proposes the addition of two branched holes from each primary hole in order to produce a vorticity counter to the detrimental kidney vortices from the main jet. These vortices typically entrain hot freestream gas and are associated with jet separation from the turbine blade surface. The anti-vortex design is unique in that it requires only easily machinable round holes, unlike shaped film cooling holes and other advanced concepts. The anti-vortex film cooling hole concept has been modeled computationally for a single row of 30deg angled holes on a flat surface using the 3D Navier-Stokes solver Glenn-HT. A modification of the anti-vortex concept whereby the branched holes exit adjacent to the main hole has been studied computationally for blowing ratios of 1.0 and 2.0 and at density ratios of 1.0 and 2.0. This modified concept was selected because it has shown the most promise in recent experimental studies. The computational results show that the modified design improves the film cooling effectiveness relative to the round hole baseline and previous anti-vortex cases, in confirmation of the experimental studies.

Human work interaction design meets international development

DEFF Research Database (Denmark)

Campos, P.; Clemmensen, T.; Barricelli, B.R.

2017-01-01

opportunity to observe technology-mediated innovative work practices in informal settings that may be related to the notion of International Development. In this unique context, this workshop proposes to analyze findings related to opportunities for design research in this type of work domains: a) human......Over the last decade, empirical relationships between work domain analysis and HCI design have been identified by much research in the field of Human Work Interaction Design (HWID) across five continents. Since this workshop takes place at the Interact Conference in Mumbai, there is a unique...

A Content Analysis of Unique Selling Propositions of Tobacco Print Ads

Science.gov (United States)

Shen, Megan Johnson; Banerjee, Smita C.; Greene, Kathryn; Carpenter, Amanda; Ostroff, Jamie S.

2017-01-01

Objectives The present study described the unique selling propositions (USPs) (propositions used to convince customers to use a particular brand/product by focusing on the unique benefit) of print tobacco ads. Methods A qualitative content analysis was conducted of print tobacco ads (N = 171) selected from August 2012-August 2013 for cigarettes, moist snuff, e-cigarettes, cigars, and snus to determine the content and themes of USPs for tobacco ads. Results Cigarette ad USP themes focused on portraying the product as attractive; moist snuff ads focused on portraying product as masculine; cigar ads focused on selling a “high end product;” and new and emerging tobacco products (e-cigarette, snus) focused on directly comparing these products to cigarettes. Conclusions Whereas traditional tobacco product ads used USPs focused on themes of enjoyment and pleasure (eg, attractive for cigarettes, “high end product” for cigars), new and emerging tobacco product ads offered the unique benefit (USP) of their product being a better and “safer” alternative to traditional tobacco products. Snuff’s USPs focused nearly exclusively on the masculinity of their products. Results of this study provide targets for potential tobacco regulatory actions that could be implemented to reduce demand for tobacco products by reducing their perceived unique benefits. PMID:28452697

The Communication Between Designer and Design Receiver

DEFF Research Database (Denmark)

Dai, Zheng; Dai, Yan

2009-01-01

When people think about a product,the first impression always mainly influences the result.Product is the medium of communication between designer and designer receiver.Because both of them have varied different experience and background,the information would be biased during the transferring...... process.The common symbols which can be recognized by both of designer and receiver are the key tools for communication.In some case,the same symbol in one product would be leads to different receiver impression.Generally,impression includes 3 aspects:aesthetics,function, and emotion.Designer needs...... to create an attractive and accurate impression in product from these 3 aspects.For facing the dilemma of communication,some experimental approaches can help designer deal with unique and diversity situations.Solving the detail problem in each step could keep the original meaning of designer....

Landmarks selection in street map design

International Nuclear Information System (INIS)

Kao, C J

2014-01-01

In Taiwan many electrical maps present their landmarks according to the category of the feature, a designer short of knowledge about mental representation of space, can cause the map to lose its communication effects. To resolve this map design problem, in this research through long-term memory recall, navigation and observation, and short-term memory processing 111 participants were asked to select the proper landmark from study area. The results reveal that in Taiwan convenience stores are the most popular local landmark in rural and urban areas. Their commercial signs have a unique design and bright color. Contrasted to their background, this makes the convenience store a salient feature. This study also developed a rule to assess the priority of the landmarks to design them in different scale maps

Landmarks selection in street map design

Science.gov (United States)

Kao, C. J.

2014-02-01

In Taiwan many electrical maps present their landmarks according to the category of the feature, a designer short of knowledge about mental representation of space, can cause the map to lose its communication effects. To resolve this map design problem, in this research through long-term memory recall, navigation and observation, and short-term memory processing 111 participants were asked to select the proper landmark from study area. The results reveal that in Taiwan convenience stores are the most popular local landmark in rural and urban areas. Their commercial signs have a unique design and bright color. Contrasted to their background, this makes the convenience store a salient feature. This study also developed a rule to assess the priority of the landmarks to design them in different scale maps.

Novel criteria of uniqueness for signal reconstruction from phase

NARCIS (Netherlands)

Ma, C.

1991-01-01

An approach for ascertaining whether a signal is uniquely determined by its Fourier transform phase is proposed. It is shown that uniqueness corresponds to the nonsingularity of a matrix which can be formed from the finite-length real sequence. The criterion of uniqueness for reconstructing a

Secondary metabolites from the unique bamboo, Melocanna baccifera.

Science.gov (United States)

Govindan, Balaji; Johnson, Anil John; Viswanathan, Gayathri; Ramaswamy, Venkataraman; Koshy, Konnath Chacko; Baby, Sabulal

2018-02-15

Phytochemistry of fruits and leaves of the unique bamboo Melocanna baccifera resulted in the isolation of 27 secondary metabolites, including 4-Oxabicyclo[3.2.2]nona-1(7),5,8-triene and Verbacine. Biological activity studies of Verbacine revealed it as an inhibitor of acetylcholinesterase and as cytotoxic against C6 cancer cells.

Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma

Directory of Open Access Journals (Sweden)

Yan Wusheng

2012-01-01

Full Text Available Abstract Background Esophageal squamous cell carcinoma (ESCC, the predominant histological subtype of esophageal cancer, is characterized by high mortality. Previous work identified important mRNA expression differences between normal and tumor cells; however, to date there are limited ex vivo studies examining expression changes occurring during normal esophageal squamous cell differentiation versus those associated with tumorigenesis. In this study, we used a unique tissue microdissection strategy and microarrays to measure gene expression profiles associated with cell differentiation versus tumorigenesis in twelve cases of patient-matched normal basal squamous epithelial cells (NB, normal differentiated squamous epithelium (ND, and squamous cell cancer. Class comparison and pathway analysis were used to compare NB versus tumor in a search for unique therapeutic targets. Results As a first step towards this goal, gene expression profiles and pathways were evaluated. Overall, ND expression patterns were markedly different from NB and tumor; whereas, tumor and NB were more closely related. Tumor showed a general decrease in differentially expressed genes relative to NB as opposed to ND that exhibited the opposite trend. FSH and IgG networks were most highly dysregulated in normal differentiation and tumorigenesis, respectively. DNA repair pathways were generally elevated in NB and tumor relative to ND indicating involvement in both normal and pathological growth. PDGF signaling pathway and 12 individual genes unique to the tumor/NB comparison were identified as therapeutic targets, and 10 associated ESCC gene-drug pairs were identified. We further examined the protein expression level and the distribution patterns of four genes: ODC1, POSTN, ASPA and IGF2BP3. Ultimately, three genes (ODC1, POSTN, ASPA were verified to be dysregulated in the same pattern at both the mRNA and protein levels. Conclusions These data reveal insight into genes and

Zeros and uniqueness of Q-difference polynomials of meromorphic ...

Indian Academy of Sciences (India)

Meromorphic functions; Nevanlinna theory; logarithmic order; uniqueness problem; difference-differential polynomial. Abstract. In this paper, we investigate the value distribution of -difference polynomials of meromorphic function of finite logarithmic order, and study the zero distribution of difference-differential polynomials ...

Design and fabrication of a sleep apnea device using computer-aided design/additive manufacture technologies.

Science.gov (United States)

Al Mortadi, Noor; Eggbeer, Dominic; Lewis, Jeffrey; Williams, Robert J

2013-04-01

The aim of this study was to analyze the latest innovations in additive manufacture techniques and uniquely apply them to dentistry, to build a sleep apnea device requiring rotating hinges. Laser scanning was used to capture the three-dimensional topography of an upper and lower dental cast. The data sets were imported into an appropriate computer-aided design software environment, which was used to design a sleep apnea device. This design was then exported as a stereolithography file and transferred for three-dimensional printing by an additive manufacture machine. The results not only revealed that the novel computer-based technique presented provides new design opportunities but also highlighted limitations that must be addressed before the techniques can become clinically viable.

Neural architecture design based on extreme learning machine.

Science.gov (United States)

Bueno-Crespo, Andrés; García-Laencina, Pedro J; Sancho-Gómez, José-Luis

2013-12-01

Selection of the optimal neural architecture to solve a pattern classification problem entails to choose the relevant input units, the number of hidden neurons and its corresponding interconnection weights. This problem has been widely studied in many research works but their solutions usually involve excessive computational cost in most of the problems and they do not provide a unique solution. This paper proposes a new technique to efficiently design the MultiLayer Perceptron (MLP) architecture for classification using the Extreme Learning Machine (ELM) algorithm. The proposed method provides a high generalization capability and a unique solution for the architecture design. Moreover, the selected final network only retains those input connections that are relevant for the classification task. Experimental results show these advantages. Copyright © 2013 Elsevier Ltd. All rights reserved.

DEVELOPING THE PHYSICS DESIGN FOR NDCX-II, A UNIQUE PULSE-COMPRESSING ION ACCELERATOR

International Nuclear Information System (INIS)

Friedman, A.; Barnard, J.J.; Cohen, R.H.; Grote, D.P.; Lund, S.M.; Sharp, W.M.; Faltens, A.; Henestroza, E.; Jung, J.-Y.; Kwan, J.W.; Lee, E.P.; Leitner, M.A.; Logan, B.G.; Vay, J.-L.; Waldron, W.L.; Davidson, R.C.; Dorf, M.; Gilson, E.P.; Kaganovich, I.

2009-01-01

The Heavy Ion Fusion Science Virtual National Laboratory (a collaboration of LBNL, LLNL, and PPPL) is using intense ion beams to heat thin foils to the 'warm dense matter' regime at ∼ + ions to ∼1 ns while accelerating it to 3-4 MeV over ∼15 m. Strong space charge forces are incorporated into the machine design at a fundamental level. We are using analysis, an interactive 1D PIC code (ASP) with optimizing capabilities and centroid tracking, and multi-dimensional Warpcode PIC simulations, to develop the NDCX-II accelerator. This paper describes the computational models employed, and the resulting physics design for the accelerator.

Reliability of digital ulcer definitions as proposed by the UK Scleroderma Study Group: A challenge for clinical trial design.

Science.gov (United States)

Hughes, Michael; Tracey, Andrew; Bhushan, Monica; Chakravarty, Kuntal; Denton, Christopher P; Dubey, Shirish; Guiducci, Serena; Muir, Lindsay; Ong, Voon; Parker, Louise; Pauling, John D; Prabu, Athiveeraramapandian; Rogers, Christine; Roberts, Christopher; Herrick, Ariane L

2018-06-01

The reliability of clinician grading of systemic sclerosis-related digital ulcers has been reported to be poor to moderate at best, which has important implications for clinical trial design. The aim of this study was to examine the reliability of new proposed UK Scleroderma Study Group digital ulcer definitions among UK clinicians with an interest in systemic sclerosis. Raters graded (through a custom-built interface) 90 images (80 unique and 10 repeat) of a range of digital lesions collected from patients with systemic sclerosis. Lesions were graded on an ordinal scale of severity: 'no ulcer', 'healed ulcer' or 'digital ulcer'. A total of 23 clinicians - 18 rheumatologists, 3 dermatologists, 1 hand surgeon and 1 specialist rheumatology nurse - completed the study. A total of 2070 (1840 unique + 230 repeat) image gradings were obtained. For intra-rater reliability, across all images, the overall weighted kappa coefficient was high (0.71) and was moderate (0.55) when averaged across individual raters. Overall inter-rater reliability was poor (0.15). Although our proposed digital ulcer definitions had high intra-rater reliability, the overall inter-rater reliability was poor. Our study highlights the challenges of digital ulcer assessment by clinicians with an interest in systemic sclerosis and provides a number of useful insights for future clinical trial design. Further research is warranted to improve the reliability of digital ulcer definition/rating as an outcome measure in clinical trials, including examining the role for objective measurement techniques, and the development of digital ulcer patient-reported outcome measures.

Operational Design for Peace Enforcement: Lessons for the Operational Staff

National Research Council Canada - National Science Library

Neumann, Michael

2004-01-01

U.S. involvement in Somalia serves as a useful case study of the unique challenges an operational staff may face when applying operational design to the planning and execution of a peace enforcement operation. U.S...

Large scale breeder reactor plant prototype mechanical pump conceptual design study

Energy Technology Data Exchange (ETDEWEB)

1976-07-01

This report includes engineering memorandums, drawings, key feature descriptions, and other data. Some of the reports, such as manufacturability and some stress analysis, were done by consultants for Byron Jackson. Review of this report indicates that the design is feasible. The pump can be manufactured to system and specification requirements. The overall length and weight of some pieces will require special consideration, but is within the scope of equipment and technology available today. The fabricated parts are large and heavy, but can be manufactured and machined. Only the high temperature is unique to this size, since previous sodium pumps were smaller. Nondestructive tests as required by the Code are described and are feasible. The performance test of the prototype has been studied thoroughly. It is feasible for a cold water test. There are some problem areas. However, all of them can be solved. Development needs include building and testing a small scale model.

Diabetes: Unique to Older Adults

Science.gov (United States)

... Stroke Urinary Incontinence Related Documents PDF Choosing Wisely: Diabetes Tests and Treatments Download Related Video Join our e-newsletter! Aging & Health A to Z Diabetes Unique to Older Adults This section provides information ...

Design and optimization of thermoacoustic devices

International Nuclear Information System (INIS)

Babaei, Hadi; Siddiqui, Kamran

2008-01-01

Thermoacoustics deals with the conversion of heat energy into sound energy and vice versa. It is a new and emerging technology which has a strong potential towards the development of sustainable and renewable energy systems by utilizing waste heat or solar energy. Although simple to fabricate, the designing of thermoacoustic devices is very challenging. In the present study, a comprehensive design and optimization algorithm is developed for designing thermoacoustic devices. The unique feature of the present algorithm is its ability to design thermoacoustically-driven thermoacoustic refrigerators that can serve as sustainable refrigeration systems. In addition, new features based on the energy balance are also included to design individual thermoacoustic engines and acoustically-driven thermoacoustic refrigerators. As a case study, a thermoacoustically-driven thermoacoustic refrigerator has been designed and optimized based on the developed algorithm. The results from the algorithm are in good agreement with that obtained from the computer code DeltaE

Using the Theory of Planned Behavior to Identify Predictors of Oral Hygiene: A Collection of Unique Behaviors.

Science.gov (United States)

Brein, Daniel J; Fleenor, Thomas J; Kim, Soo-Woo; Krupat, Edward

2016-03-01

This study aims to identify predictors of performed oral hygiene behaviors (OHBs) based on the Theory of Planned Behavior (TPB), oral health knowledge, and demographic factors. Using a questionnaire, 381 participants in three general dental offices and one hospital dental department in York, Pennsylvania, were surveyed regarding performed OHB, attitudes, subjective norms, perceived behavioral control, oral health knowledge, income, age, and sex. Three unique elements of OHB were identified for analysis: brushing, interdental cleaning, and tongue cleaning. Regression analysis revealed that attitude was the strongest predictor of brushing behavior, followed by oral health knowledge, perceived behavior control, subjective norms, and income. Perceived behavior control was the strongest predictor of interdental cleaning, followed by increased age and attitude. Female sex was the strongest predictor of tongue cleaning, followed by subjective norms, decreased age, and perceived behavior control. Respectively, these three groups of predictive variables explained 22.5% of brushing behavior, 22.7% of interdental cleaning behavior, and 9.5% of tongue cleaning behavior. The present findings highlight the utility of viewing OHB as a set of unique behaviors with unique predictive variables and provide additional support for use of TPB in predicting OHB. Periodontal practitioners should consider the strong associations of attitude and perceived behavioral control with brushing and interdental cleaning behaviors when designing interventional efforts to improve patient home care.

Cryogenic vacuum pump design

International Nuclear Information System (INIS)

Bartlett, A.J.; Lessard, P.A.

1984-01-01

This paper is a review of the problems and tradeoffs involved in cryogenic vacuum pump analysis, design and manufacture. Particular attention is paid to the several issues unique to cryopumps, e.g., radiation loading, adsorption of noncondensible gases, and regeneration. A general algorithm for cryopump design is also proposed. 12 references

Might "Unique" Factors Be "Common"? On the Possibility of Indeterminate Common-Unique Covariances

Science.gov (United States)

Grayson, Dave

2006-01-01

The present paper shows that the usual factor analytic structured data dispersion matrix lambda psi lambda' + delta can readily arise from a set of scores y = lambda eta + epsilon, shere the "common" (eta) and "unique" (epsilon) factors have nonzero covariance: gamma = Cov epsilon,eta) is not equal to 0. Implications of this finding are discussed…

Barriers to Strategic Design: A Perspective from China

Directory of Open Access Journals (Sweden)

Sylvia Xihui Liu

Full Text Available Strategic design is a driver for innovation that can lead to sustainable competitive advantage. Over the past two decades, the barriers limiting breakthrough strategic design development have been studied in much detail. However, that research is based on well-developed practices in Europe, where strategic design and innovation capabilities have been nurtured for a long period. Barriers to the adoption of strategic design practices and leadership have seldom been studied in high growth economies in which design and innovation competencies are not yet mature. We examined design-led innovation cases from Chinese design clients and consultancies, and uncovered twelve barriers to strategic design practice and leadership in China. Six of these are similar to hindrances experienced elsewhere, and the other six are unique to this study. We found that in China, certain constraints limiting the adoption of strategic design in practice exist in the environment outside the firm. Based on these findings, we offer suggestions to stakeholders for overcoming the barriers to utilizing design at the strategic level. Key words: Breakthrough innovation, Design-led innovation, Design implementation, Strategic design

review article how unique is south african military integration?

African Journals Online (AJOL)

Roy Licklider

Rutgers University. The study of civil war ... South Africa has a strong case to be the poster child of military integration after civil violence.6 In a .... One aspect of the South African response to this problem was unique: a. Defence White Paper ...

Event segmentation ability uniquely predicts event memory.

Science.gov (United States)

Sargent, Jesse Q; Zacks, Jeffrey M; Hambrick, David Z; Zacks, Rose T; Kurby, Christopher A; Bailey, Heather R; Eisenberg, Michelle L; Beck, Taylor M

2013-11-01

Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan. Copyright © 2013 Elsevier B.V. All rights reserved.

Study designs may influence results

DEFF Research Database (Denmark)

Johansen, Christoffer; Schüz, Joachim; Andreasen, Anne-Marie Serena

2017-01-01

appeared to show an inverse association, whereas nested case-control and cohort studies showed no association. For allergies, the inverse association was observed irrespective of study design. We recommend that the questionnaire-based case-control design be placed lower in the hierarchy of studies...... for establishing cause-and-effect for diseases such as glioma. We suggest that a state-of-the-art case-control study should, as a minimum, be accompanied by extensive validation of the exposure assessment methods and the representativeness of the study sample with regard to the exposures of interest. Otherwise...

SPFC bus design studies

Energy Technology Data Exchange (ETDEWEB)

Potter, L.; Reinkingh, J.

1999-07-01

This report presents the results of a study assessing the design options for a solid polymer fuel cell bus. Commercial and operation requirements, environmental and market drivers, and fuel processor modeling are examined. Power train specifications and detailed system design are investigated covering fuel cell system dynamic response, hybrid system size, fuel cell system start-up time, system specifications, and hybrid bus component dimensions and costs. (UK)

Unique differences in applying safety analyses for a graphite moderated, channel reactor

International Nuclear Information System (INIS)

Moffitt, R.L.

1993-06-01

Unlike its predecessors, the N Reactor at the Hanford Site in Washington State was designed to produce electricity for civilian energy use as well as weapons-grade plutonium. This paper describes the major problems associated with applying safety analysis methodologies developed for commercial light water reactors (LWR) to a unique reactor like the N Reactor. The focus of the discussion is on non-applicable LWR safety standards and computer modeling/analytical variances of standards. The approaches used to resolve these problems to develop safety standards and limits for the N Reactor are described

Collective design in 3D printing: A large scale empirical study of designs, designers and evolution

DEFF Research Database (Denmark)

Özkil, Ali Gürcan

2017-01-01

This paper provides an empirical study of a collective design platform (Thingiverse); with the aim of understanding the phenomenon and investigating how designs concurrently evolve through the large and complex network of designers. The case study is based on the meta-data collected from 158 489 ...

The unique experience of adults with multimorbidity: a qualitative study

Directory of Open Access Journals (Sweden)

Cynthia Duguay

2014-05-01

Full Text Available Background: Findings from several countries indicate that the prevalence of multimorbidity is very high among clients of primary healthcare. A deeper understanding of patients’ experiences from their own perspective can greatly enrich any intervention to help them live as well as possible with multimorbidity. Objective: To describe the fundamental structure of adults’ experience with multimorbidity. Design: A phenomenological study was undertaken to describe the experiences of 11 adults with multimorbidity. These adults participated in two semi-structured interviews, the content of which was rigorously analyzed. Results: At the core of the study participants’ multimorbidity experience are the impression of aging prematurely, difficulties with self-care management, and issues with access to the healthcare system, which contribute to the problem’s complexity. Despite these issues, participants with multimorbidity report attempting to take control of their situation and adjusting to daily living. Conclusions: The description of this experience, through the systemic vision of participants, provides a better understanding of the realities experienced by people with multimorbidity.

How system designers think: a study of design thinking in human factors engineering.

Science.gov (United States)

Papantonopoulos, Sotiris

2004-11-01

The paper presents a descriptive study of design thinking in human factors engineering. The objective of the study is to analyse the role of interpretation in design thinking and the role of design practice in guiding interpretation. The study involved 10 system designers undertaking the allocation of cognitive functions in three production planning and control task scenarios. Allocation decisions were recorded and verbal protocols of the design process were collected to elicit the subjects' thought processes. Verbal protocol analysis showed that subjects carried out the design of cognitive task allocation as a problem of applying a selected automation technology from their initial design deliberations. This design strategy stands in contrast to the predominant view of system design that stipulates that user requirements should be thoroughly analysed prior to making any decisions about technology. Theoretical frameworks from design research and ontological design showed that the system design process may be better understood by recognizing the role of design hypotheses in system design, as well as the diverse interactions between interpretation and practice, means and ends, and design practice and the designer's pre-understanding which shape the design process. Ways to balance the bias exerted on the design process were discussed.

Design Research

DEFF Research Database (Denmark)

Design Research is a new interdisciplinary research area with a social science orientation at its heart, and this book explores how scientific knowledge can be put into practice in ways that are at once ethical, creative, helpful, and extraordinary in their results. In order to clarify the common...... aspects – in terms of features and approaches – that characterize all strands of research disciplines addressing design, Design Research undertakes an in depth exploration of the social processes involved in doing design, as well as analyses of the contexts for design use. The book further elicits...... ‘synergies from interdisciplinary perspectives’ by discussing and elaborating on differing academic perspectives, theoretical backgrounds, and design concept definitions, and evaluating their unique contribution to a general core of design research. This book is an exciting contribution to this little...

Unique expression of cytoskeletal proteins in human soft palate muscles.

Science.gov (United States)

Shah, Farhan; Berggren, Diana; Holmlund, Thorbjörn; Levring Jäghagen, Eva; Stål, Per

2016-03-01

The human oropharyngeal muscles have a unique anatomy with diverse and intricate functions. To investigate if this specialization is also reflected in the cytoarchitecture of muscle fibers, intermediate filament proteins and the dystrophin-associated protein complex have been analyzed in two human palate muscles, musculus uvula (UV) and musculus palatopharyngeus (PP), with immunohistochenmical and morphological techniques. Human limb muscles were used as reference. The findings show that the soft palate muscle fibers have a cytoskeletal architecture that differs from the limb muscles. While all limb muscles showed immunoreaction for a panel of antibodies directed against different domains of cytoskeletal proteins desmin and dystrophin, a subpopulation of palate muscle fibers lacked or had a faint immunoreaction for desmin (UV 11.7% and PP 9.8%) and the C-terminal of the dystrophin molecule (UV 4.2% and PP 6.4%). The vast majority of these fibers expressed slow contractile protein myosin heavy chain I. Furthermore, an unusual staining pattern was also observed in these fibers for β-dystroglycan, caveolin-3 and neuronal nitric oxide synthase nNOS, which are all membrane-linking proteins associated with the dystrophin C-terminus. While the immunoreaction for nNOS was generally weak or absent, β-dystroglycan and caveolin-3 showed a stronger immunostaining. The absence or a low expression of cytoskeletal proteins otherwise considered ubiquitous and important for integration and contraction of muscle cells indicate a unique cytoarchitecture designed to meet the intricate demands of the upper airway muscles. It can be concluded that a subgroup of muscle fibers in the human soft palate appears to have special biomechanical properties, and their unique cytoarchitecture must be taken into account while assessing function and pathology in oropharyngeal muscles. © 2015 Anatomical Society.

Can facial uniqueness be inferred from impostor scores?

NARCIS (Netherlands)

Dutta, A.; Veldhuis, Raymond N.J.; Spreeuwers, Lieuwe Jan

2013-01-01

In Biometrics, facial uniqueness is commonly inferred from impostor similarity scores. In this paper, we show that such uniqueness measures are highly unstable in the presence of image quality variations like pose, noise and blur. We also experimentally demonstrate the instability of a recently

Kosovo case: A unique arbitrariness

Directory of Open Access Journals (Sweden)

Nakarada Radmila

2007-01-01

Full Text Available The end of Cold war, contrary to expectations has brought new conflicts and forms of violence, new divisions and new relativizations of the international legal order. Taking as an example the endeavors to resolve the Kosovo conflict, the author attempts to indicate the broader implications of the international efforts to constitute an independent state on part of the territory of an existing sovereign state. The arguments used to justify the redefinition of the borders of the Serbian state without its consent, the moral, democratic, peace arguments, are reviewed. Particular attention is paid to the argument that Kosovo is a unique case and therefore unique rules should be applied. The author seeks to understand the deeper significance of these efforts, concluding that dismantling the present international legal order is not only a potential danger but a possible aim.

Design theory methods and organization for innovation

CERN Document Server

Le Masson, Pascal; Hatchuel, Armand

2017-01-01

This textbook presents the core of recent advances in design theory and its implications for design methods and design organization. Providing a unified perspective on different design methods and approaches, from the most classic (systematic design) to the most advanced (C-K theory), it offers a unique and integrated presentation of traditional and contemporary theories in the field. Examining the principles of each theory, this guide utilizes numerous real life industrial applications, with clear links to engineering design, industrial design, management, economics, psychology and creativity. Containing a section of exams with detailed answers, it is useful for courses in design theory, engineering design and advanced innovation management. "Students and professors, practitioners and researchers in diverse disciplines, interested in design, will find in this book a rich and vital source for studying fundamental design methods and tools as well as the most advanced design theories that work in practice". Pro...

FFAG Designs for the International Design Study for the Neutrino Factory

Energy Technology Data Exchange (ETDEWEB)

Berg, J.S.; Machida, S.

2009-05-04

The International Design Study for the Neutrino Factory (IDS-NF) aims to produce a design report for a neutrino factory. One component of that design is a linear nonscaling fixed-field alternating gradient accelerator (FFAG) that will accelerate to the final energy of 25 GeV. An FFAG is used to reduce the machine cost by maximizing the number of passes made through the RF cavities. We present some design options for this FFAG, individually optimized for cost. We study the addition of nonlinear magnets to the lattice to improve the performance of the lattice and consider the negative effects of doing so.

Unique Results and Lessons Learned From the TSS Missions

Science.gov (United States)

Stone, Nobie H.

2016-01-01

The Tethered Satellite System (TSS) Space Shuttle missions, TSS-1 in 1993 and TSS-1R in 1996, were the height of space tether technology development in the U.S. Altogether, the investment made by NASA and the Italian Space Agency (ASI) over the thirteen-year period of the TSS Program totaled approximately $400M-exclusive of the two Space Shuttle flights provided by NASA. Since those two pioneering missions, there have been several smaller tether flight experiments, but interest in this promising technology has waned within NASA as well as the DOD agencies. This is curious in view of the unique capabilities of space tether systems and the fact that they have been flight validated in earth orbit and shown to perform better than the preflight dynamic or electrodynamic theoretical predictions. While it is true that the TSS-1 and TSS-1R missions experienced technical difficulties, the causes of these early developmental problems are now known to have been engineering design flaws, material selection, and procedural issues that (1) are unrelated to the basic viability of space tether technology, and (2) can be readily corrected. The purpose of this paper is to review the dynamic and electrodynamic fundamentals of space tethers and the unique capabilities they afford (that are enabling to certain types of space missions); to elucidate the nature, cause, and solution of the early developmental problems; and to provide an update on progress made in development of the technology.

On the Existence of Unique Equilibria in Location Models

NARCIS (Netherlands)

Webers, H.M.

1996-01-01

In this paper, we study a two-stage location-then-price game where consumers are distributed piecewise uniformly, each piece being referred to as an interval.Although the firms face a coordination problem, it is obvious that, for any given locations and prices, there is a unique indifferent

FED/INTOR reactor design studies

International Nuclear Information System (INIS)

Brown, T.G.; Cramer, B.A.; Davisson, J.P.; Kunselman, M.H.; Reiersen, W.T.; Sager, P.H.; Strickler, D.J.

1982-03-01

Upon completing the design studies identified in this report, an overall assessment of the design options is made that will form the bases to define the configuration of the next major Tokamak device. The TF coil size will be defined, along with the vacuum boundary, the PF coil arrangement, and the torus configuration. After the configuration is established, an overall performance and cost re-assessment should be made to finally trade off device performance with machine capital and operating costs to establish a reactor design point for a given set of design requirements

A unique cabling designed to produce Rutherford-type superconducting cable for the SSC project

International Nuclear Information System (INIS)

Grisel, J.; Royet, J.M.; Scanlan, R.M.; Armer, R.

1988-08-01

Up to 25,000 Km of keystoned flat cable must be produced for the SSC project. Starting from a specification developed by Lawrence Berkeley Laboratory (LBL), a special cabling machine has been designed by Dour Metal. It has been designed to be able to run at a speed corresponding to a maximum production rate of 10 m/min. This cabling machine is the key part of the production line which consists of a precision Turkshead equipped with a variable power drive, a caterpillar, a dimensional control bench, a data acquisition system, and a take-up unit. The main features of the cabling unit to be described are a design with nearly equal path length between spool and assembling point for all the wires, and the possibility to run the machine with several over- or under-twisting ratios between cable and wires. These requirements led Dour Metal to the choice of an unconventional mechanical concept for a cabling machine. 4 refs., 2 figs

The method of selecting an integrated development territory for the high-rise unique constructions

Science.gov (United States)

Sheina, Svetlana; Shevtsova, Elina; Sukhinin, Alexander; Priss, Elena

2018-03-01

On the basis of data provided by the Department of architecture and urban planning of the city of Rostov-on-don, the problem of the choice of the territory for complex development that will be in priority for the construction of high-rise and unique buildings is solved. The objective of the study was the development of a methodology for selection of the area and the implementation of the proposed method on the example of evaluation of four-territories complex development. The developed method along with standard indicators of complex evaluation considers additional indicators that assess the territory from the position of high-rise unique building. The final result of the study is the rankings of the functional priority areas that takes into account the construction of both residential and public and business objects of unique high-rise construction. The use of the developed methodology will allow investors and customers to assess the investment attractiveness of the future unique construction project on the proposed site.

Deriving Design Flood Hydrograph Based on Conditional Distribution: A Case Study of Danjiangkou Reservoir in Hanjiang Basin

Directory of Open Access Journals (Sweden)

Changjiang Xu

2016-01-01

Full Text Available Design flood hydrograph (DFH for a dam is the flood of suitable probability and magnitude adopted to ensure safety of the dam in accordance with appropriate design standards. Estimated quantiles of peak discharge and flood volumes are necessary for deriving the DFH, which are mutually correlated and need to be described by multivariate analysis methods. The joint probability distributions of peak discharge and flood volumes were established using copula functions. Then the general formulae of conditional most likely composition (CMLC and conditional expectation composition (CEC methods that consider the inherent relationship between flood peak and volumes were derived for estimating DFH. The Danjiangkou reservoir in Hanjiang basin was selected as a case study. The design values of flood volumes and 90% confidence intervals with different peak discharges were estimated by the proposed methods. The performance of CMLC and CEC methods was also compared with conventional flood frequency analysis, and the results show that CMLC method performs best for both bivariate and trivariate distributions which has the smallest relative error and root mean square error. The proposed CMLC method has strong statistical basis with unique design flood composition scheme and provides an alternative way for deriving DFH.

Domestic food and sustainable design : a study of university student cooking and its impacts

OpenAIRE

Clear, Adrian; Hazas, Michael; Morley, Janine; Friday, Adrian; Bates, Oliver

2013-01-01

In four university student kitchens over twenty-one days, we captured participants' food preparation activity, quantified the greenhouse gas emissions and direct energy connected to the food and cooking, and talked to participants about their food practices. Grounded in this uniquely detailed micro-account, our findings inform sustainable design for cooking and eating at home and quantify the potential impacts. We outline the relation of the impacts to our participants' approaches to everyday...

Constructing a unique two-phase compressibility factor model for lean gas condensates

Energy Technology Data Exchange (ETDEWEB)

Moayyedi, Mahmood; Gharesheikhlou, Aliashghar [Research Institute of Petroleum Industry (RIPI), Tehran (Iran, Islamic Republic of); Azamifard, Arash; Mosaferi, Emadoddin [Amirkabir University of Technology (AUT), Tehran (Iran, Islamic Republic of)

2015-02-15

Generating a reliable experimental model for two-phase compressibility factor in lean gas condensate reservoirs has always been demanding, but it was neglected due to lack of required experimental data. This study presents the main results of constructing the first two-phase compressibility factor model that is completely valid for Iranian lean gas condensate reservoirs. Based on a wide range of experimental data bank for Iranian lean gas condensate reservoirs, a unique two-phase compressibility factor model was generated using design of experiments (DOE) method and neural network technique (ANN). Using DOE, a swift cubic response surface model was generated for two-phase compressibility factor as a function of some selected fluid parameters for lean gas condensate fluids. The proposed DOE and ANN models were finally validated using four new independent data series. The results showed that there is a good agreement between experimental data and the proposed models. In the end, a detailed comparison was made between the results of proposed models.

Constructing a unique two-phase compressibility factor model for lean gas condensates

International Nuclear Information System (INIS)

Moayyedi, Mahmood; Gharesheikhlou, Aliashghar; Azamifard, Arash; Mosaferi, Emadoddin

2015-01-01

Generating a reliable experimental model for two-phase compressibility factor in lean gas condensate reservoirs has always been demanding, but it was neglected due to lack of required experimental data. This study presents the main results of constructing the first two-phase compressibility factor model that is completely valid for Iranian lean gas condensate reservoirs. Based on a wide range of experimental data bank for Iranian lean gas condensate reservoirs, a unique two-phase compressibility factor model was generated using design of experiments (DOE) method and neural network technique (ANN). Using DOE, a swift cubic response surface model was generated for two-phase compressibility factor as a function of some selected fluid parameters for lean gas condensate fluids. The proposed DOE and ANN models were finally validated using four new independent data series. The results showed that there is a good agreement between experimental data and the proposed models. In the end, a detailed comparison was made between the results of proposed models

The Relations of Family Members’ Unique and Shared Perspectives of Family Dysfunction to Dyad Adjustment

Science.gov (United States)

Jager, Justin; Yuen, Cynthia X.; Bornstein, Marc H.; Putnick, Diane L.; Hendricks, Charlene

2017-01-01

Among a community sample of families (N = 128), this study examined how family members’ shared and unique perspectives of family dysfunction relate to dyad members’ shared views of dyad adjustment within adolescent-mother, adolescent-father, and mother-father dyads. Independent of a family’s family perspective (shared perspective of family dysfunction), the adolescent’s unique perspective was associated with lower security and higher conflict with both mother and father, the father’s unique perspective was associated with lower security and higher conflict with the adolescent as well as lower marital quality with mother, and the mother unique perspective was associated with lower marital quality with the father. Moreover, for adolescent-parent dyads, compared to the parent unique perspective, the adolescent unique perspective was more strongly associated with dyad adjustment. These findings indicate that both shared and unique views of the family system – the adolescent’s unique view in particular - independently relate to the health of family subsystems. They also suggest that research as well as therapeutic interventions that focus on just the shared view of the family may miss important elements of family dysfunction. PMID:24884682

Exploring the design space of shape-changing objects

DEFF Research Database (Denmark)

Nørgaard, Mie; Merritt, Timothy Robert; Rasmussen, Majken

2013-01-01

In this paper we describe the outcomes from a design exercise in which eight groups of designers designed and built hardware sketches in the form of playful shape-changing prototypes, generatively working with Rasmussen et al's [31] eight unique types of shape change. Seeing that shape-changing i......In this paper we describe the outcomes from a design exercise in which eight groups of designers designed and built hardware sketches in the form of playful shape-changing prototypes, generatively working with Rasmussen et al's [31] eight unique types of shape change. Seeing that shape...... for the further expansion of the design space of shape changing interfaces relating to the perception and understanding of behaviour, causality and the mechanics involved in shape change events, which we call "Imagined Physics." This concept is described along with additional insights into the qualities of shape...

A Comparison of Reinforcement Sensitivity Theory Measures: Unique Associations With Social Interaction Anxiety and Social Observation Anxiety.

Science.gov (United States)

Kramer, Sam L; Rodriguez, Benjamin F

2018-07-01

Evidence suggests that the behavior inhibition system (BIS) and fight-flight-freeze system play a role in the individual differences seen in social anxiety disorder; however, findings concerning the role of the behavior approach system (BAS) have been mixed. To date, the role of revised reinforcement sensitivity theory (RST) subsystems underlying social anxiety has been measured with scales designed for the original RST. This study examined how the BIS, BAS, and fight, flight, freeze components of the fight-flight-freeze system uniquely relate to social interaction anxiety and social observation anxiety using both a measure specifically designed for the revised RST and a commonly used original RST measure. Comparison of regression analyses with the Jackson-5 and the commonly used BIS/BAS Scales revealed important differences in the relationships between RST subsystems and social anxiety depending on how RST was assessed. Limitations and future directions for revised RST measurement are discussed.

Need for Uniqueness Determines Reactions to Web-Based Personalized Advertising.

Science.gov (United States)

Stiglbauer, Barbara; Kovacs, Carrie

2018-01-01

The presented empirical study among a sample of n = 256 participants addressed the relationship between consumers' need for uniqueness and their reactions to web-based personalized advertising. Drawing on regulatory focus theory, we argue that the consumers' need for uniqueness dimensions creative choice and similarity avoidance may relate to promotion and prevention regulatory orientations, respectively. Accordingly, we hypothesized that creative choice and similarity avoidance would differentially predict self-reported approach and avoidance behavior toward personalized advertising. These direct relationships were further expected to be mediated by subjective evaluations of personalized advertising (i.e., perceived value and irritation). In line with these hypotheses, we found that creative choice predicted approach behavior through increased web-based personalized advertising value, whereas similarity avoidance predicted avoidance behavior through increased irritation. Creative choice also predicted decreased irritation, which in turn was related to decreased approach behavior. In sum, the results suggest that the consumers' need for uniqueness dimensions should not be investigated as a composite, as they seem to reflect different regulatory orientations and are therefore likely to evoke different affective, cognitive, and behavioral responses.

Atlantic Coast Unique Regional Atmospheric Tracer Experiment (ACURATE)

International Nuclear Information System (INIS)

Schubert, J.F.; Heffter, J.L.; Mead, G.A.

1983-05-01

The Atlantic Coast Unique Regional Atmospheric Tracer Experiment (ACURATE) is a program designed to obtain data necessary to evaluate atmospheric transport and diffusion models used to calculate regional population doses caused by nuclear facility emissions to the atmosphere. This experiment will significantly improve the basis for evaluating the cost effectiveness of different methods of managing airborne nuclear wastes. During the period from March 1982 through September 1982, twice daily air samples have been collected at each of five sampling stations located on a radial from the SRP to Murray Hill, NJ (1000 km). Kr-85 emitted from the F and H area chemical separations facilities is being used as a tracer to determine the transport and diffusion of atmospheric releases from the SRP. The Kr-85 concentrations in the air samples will be compared with the calculated concentrations as predicted by the transport and diffusion models. The Kr-85 data and the meteorological data are being archived and will be made available to the modeling community

Design concept for α-hydrogen-substituted nitroxides.

Science.gov (United States)

Amar, Michal; Bar, Sukanta; Iron, Mark A; Toledo, Hila; Tumanskii, Boris; Shimon, Linda J W; Botoshansky, Mark; Fridman, Natalia; Szpilman, Alex M

2015-02-06

Stable nitroxides (nitroxyl radicals) have many essential and unique applications in chemistry, biology and medicine. However, the factors influencing their stability are still under investigation, and this hinders the design and development of new nitroxides. Nitroxides with tertiary alkyl groups are generally stable but obviously highly encumbered. In contrast, α-hydrogen-substituted nitroxides are generally inherently unstable and rapidly decompose. Herein, a novel, concept for the design of stable cyclic α-hydrogen nitroxides is described, and a proof-of-concept in the form of the facile synthesis and characterization of two diverse series of stable α-hydrogen nitroxides is presented. The stability of these unique α-hydrogen nitroxides is attributed to a combination of steric and stereoelectronic effects by which disproportionation is kinetically precluded. These stabilizing effects are achieved by the use of a nitroxide co-planar substituent in the γ-position of the backbone of the nitroxide. This premise is supported by a computational study, which provides insight into the disproportionation pathways of α-hydrogen nitroxides.

Frustrated Lewis pairs: Design and reactivity

Indian Academy of Sciences (India)

for FLP systems and their unique reactivity are discussed here. Keywords. Lewis .... we will concentrate on the design principles of such. FLPs and the ... Designs of frustrated Lewis pairs ..... 64 and neutral titanium (III) complex [Cp2TiOC6.

Unique associations between young adult men's emotional functioning and their body dissatisfaction and disordered eating.

Science.gov (United States)

Griffiths, Scott; Angus, Douglas; Murray, Stuart B; Touyz, Stephen

2014-03-01

Research on emotional functioning, body dissatisfaction, and disordered eating in males is predominated by studies of negative affect and emotion regulation. Other aspects of emotional functioning, namely emotion recognition and attentional biases toward emotional stimuli, have received little empirical attention. The present study investigated the unique associations between different aspects of men's emotional functioning and their disordered eating attitudes, muscularity dissatisfaction, and body fat dissatisfaction. Results from 132 male undergraduates showed that muscularity dissatisfaction was uniquely associated with both emotion regulation difficulties and an attentional bias toward rejecting faces. Body fat dissatisfaction was not uniquely associated with any aspect of emotional functioning. Disordered eating was uniquely associated with emotion regulation difficulties. Collectively, the results indicate differences in the patterns of associations between men's emotional functioning and their body dissatisfaction and disordered eating. Copyright © 2013 Elsevier Ltd. All rights reserved.

DECISIONS ET COMPETITIVITE SUR LE MARCHE UNIQUE EUROPEEN

Directory of Open Access Journals (Sweden)

Sirghi Nicoleta

2008-05-01

Full Text Available L’un des traits importants du marché unique européen, a comme source le męme énoncé du principal objectif de l’intégration européenne ainsi que: l’harmonisation des niveaux du développement des Etats Membres et l’augmentation du niveau de vie dans l’ensemble de la communauté. Pour le marché unique européen, cet aspect se traduit par une permanente et soutenue augmentation de la demande. Cet ouvrage présente au début une analyse des éléments spécifiques du marché européen. Ensuite on identifie les opportunités et les risques au niveau macroéconomique adjointes aux perspectives du marché unique européen. Comme fondement on présente des stratégies du développement réalisables au niveau microéconomique que puissent assurer l’augmentation du niveau sur la compétitivité des sociétés sur le marché unique européen.

Sufficient conditions for uniqueness of the weak value

International Nuclear Information System (INIS)

Dressel, J; Jordan, A N

2012-01-01

We review and clarify the sufficient conditions for uniquely defining the generalized weak value as the weak limit of a conditioned average using the contextual values formalism introduced in Dressel, Agarwal and Jordan (2010 Phys. Rev. Lett. http://dx.doi.org/10.1103/PhysRevLett.104.240401). We also respond to criticism of our work by Parrott (arXiv:1105.4188v1) concerning a proposed counter-example to the uniqueness of the definition of the generalized weak value. The counter-example does not satisfy our prescription in the case of an underspecified measurement context. We show that when the contextual values formalism is properly applied to this example, a natural interpretation of the measurement emerges and the unique definition in the weak limit holds. We also prove a theorem regarding the uniqueness of the definition under our sufficient conditions for the general case. Finally, a second proposed counter-example by Parrott (arXiv:1105.4188v6) is shown not to satisfy the sufficiency conditions for the provided theorem. (paper)

Unique Physician Identification Number (UPIN) Directory

Data.gov (United States)

U.S. Department of Health & Human Services — The Unique Physician Identification Number (UPIN) Directory contains selected information on physicians, doctors of Osteopathy, limited licensed practitioners and...

Evaluating the Physical Environment of Design Studios: A Case study in Malaysian Private Architecture Schools

Directory of Open Access Journals (Sweden)

Shanthi Muniandy

2015-09-01

Full Text Available Understanding the notion of learner’s experiences in the design of physical environment of an architecture design studio is a necessity as it contains certain values of influence. It is due to the unique learning experiences which are accrued particularly in design studio that is continued during professional practice as well. Most architectural campuses in Malaysian Private Higher Education Institutions (MPHEI are devoid of certain important elements and this issue needs to be looked into seriously. Apparently, most architectural design studios today have different physical settings, and have developed their own learning culture based on the typical space that they have. Reviewing the physical environment and how it contributes to the social environ-ment in MPHEI’s architectural context requires certain understanding on the learner’s psycho-logical needs, expectations and in the same time to meet the educational objective which is never an easy task. Hence, this paper reviewed the studies of the possible physical environment approaches in connecting the learner’s connections in architecture studio learning environ-ment. A questionnaire survey with Likert-scale components, and semi-structured interview on learners of five distinguished Private Architectural schools in Malaysia unveiled several signifi-cant findings that can lead entrepreneurs to upgrade the physical environment of these MPHEIs in order to cope with the demands of the stakeholders.

Unique prediction of cannabis use severity and behaviors by delay discounting and behavioral economic demand.

Science.gov (United States)

Strickland, Justin C; Lile, Joshua A; Stoops, William W

2017-07-01

Few studies have simultaneously evaluated delay discounting and behavioral economic demand to determine their unique contribution to drug use. A recent study in cannabis users found that monetary delay discounting uniquely predicted cannabis dependence symptoms, whereas cannabis demand uniquely predicted use frequency. This study sought to replicate and extend this research by evaluating delay discounting and behavioral economic demand measures for multiple commodities and including a use quantity measure. Amazon.com's Mechanical Turk was used to sample individuals reporting recent cannabis use (n=64) and controls (n=72). Participants completed measures of monetary delay discounting as well as alcohol and cannabis delay discounting and demand. Cannabis users and controls did not differ on monetary delay discounting or alcohol delay discounting and demand. Among cannabis users, regression analyses indicated that cannabis delay discounting uniquely predicted use severity, whereas cannabis demand uniquely predicted use frequency and quantity. These effects remained significant after controlling for other delay discounting and demand measures. This research replicates previous outcomes relating delay discounting and demand with cannabis use and extends them by accounting for the contribution of multiple commodities. This research also demonstrates the ability of online crowdsourcing methods to complement traditional human laboratory techniques. Copyright © 2017 Elsevier B.V. All rights reserved.

Photo-Elicitation and Visual Semiotics: A Unique Methodology for Studying Inclusion for Children with Disabilities

Science.gov (United States)

Stockall, Nancy

2013-01-01

The methodology in this paper discusses the use of photographs as an elicitation strategy that can reveal the thinking processes of participants in a qualitatively rich manner. Photo-elicitation techniques combined with a Piercian semiotic perspective offer a unique method for creating a frame of action for later participant analysis. Illustrative…

Unique Outcomes in the Narratives of Young Adults Who Experienced Dating Violence as Adolescents.

Science.gov (United States)

Draucker, Claire Burke; Smith, Carolyn; Mazurczyk, Jill; Thomas, Destini; Ramirez, Patricia; McNealy, Kim; Thomas, Jade; Martsolf, Donna S

2016-01-01

Narrative therapy, an approach based on the reauthoring of life narratives, may be a useful psychotherapeutic strategy for youth who have experienced dating violence. A cornerstone of narrative therapy is the concept of unique outcomes, which are moments that stand in contrast to a client's otherwise problem-saturated narratives. The purpose of this study was to identify and categorize unique outcomes embedded in narratives about adolescent dating violence. Text units representing unique outcomes were extracted from transcripts of interviews with 88 young adults who had experienced dating violence and were categorized using standard content analytic techniques. Six categories of unique outcome stories were identified: facing-facts stories, standing-up-for-myself stories, cutting-it-off stories, cutting-'em-loose stories, getting-back-on-track stories, and changing-it-up stories. This typology of unique outcomes can inform clinicians who work with clients who have a history of adolescent dating violence. © The Author(s) 2015.

Interactive system design using the complementarity of axiomatic design and fault tree analysis

International Nuclear Information System (INIS)

Heo, Gyun Young; Do, Sung Hee; Lee, Tae Sik

2007-01-01

To efficiently design safety-critical systems such as nuclear power plants, with requirement of high reliability, methodologies allowing for rigorous interactions between the synthesis and analysis processes have been proposed. This paper attempts to develop a reliability-centered design framework through an interactive process between Axiomatic Design (AD) and Fault Tree Analysis (FTA). Integrating AD and FTA into a single framework appears to be a viable solution, as they compliment each other with their unique advantages. AD provides a systematic synthesis tool while FTA is commonly used as a safety analysis tool. These methodologies build a design process that is less subjective, and they enable designers to develop insights that lead to solutions with improved reliability. Due to the nature of the two methodologies, the information involved in each process is complementary: a success tree versus a fault tree. Thus, at each step a system using AD is synthesized, and its reliability is then quantified using the FT derived from the AD synthesis process. The converted FT provides an opportunity to examine the completeness of the outcome from the synthesis process. This study presents an example of the design of a Containment Heat Removal System (CHRS). A case study illustrates the process of designing the CHRS with an interactive design framework focusing on the conversion of the AD process to FTA

Techniques for Conducting Effective Concept Design and Design-to-Cost Trade Studies

Science.gov (United States)

Di Pietro, David A.

2015-01-01

Concept design plays a central role in project success as its product effectively locks the majority of system life cycle cost. Such extraordinary leverage presents a business case for conducting concept design in a credible fashion, particularly for first-of-a-kind systems that advance the state of the art and that have high design uncertainty. A key challenge, however, is to know when credible design convergence has been achieved in such systems. Using a space system example, this paper characterizes the level of convergence needed for concept design in the context of technical and programmatic resource margins available in preliminary design and highlights the importance of design and cost evaluation learning curves in determining credible convergence. It also provides techniques for selecting trade study cases that promote objective concept evaluation, help reveal unknowns, and expedite convergence within the trade space and conveys general practices for conducting effective concept design-to-cost studies.

Some design aspects of transuranic field studies

International Nuclear Information System (INIS)

Gilbert, R.O.; Eberhardt, L.L.

1977-01-01

In this paper, we discuss some design aspects of transuranic field studies. Some of the principal steps in the design of such studies are given and illustrated using examples. This is followed by a review of sampling designs that have been used at nuclear detonation and safety-shot sites on the Nevada Test Site and elsewhere for estimating spatial pattern and total amounts in soil. Some design aspects of ecosystem-type transuranic studies for estimating total amounts as well as movement of transuranics between ecosystem components are also discussed. Acceptance sampling using either attributes or measurements is considered as a possible approach for deciding whether to clean up a contaminated site. Three general guidelines for the design of efficient transuranic studies are presented

Exploring the Design Space of Shape-Changing Objects

DEFF Research Database (Denmark)

Merritt, Timothy; Petersen, Marianne Graves; Nørgaard, Mie

2015-01-01

In this paper we describe the outcomes from a design exercise in which eight groups of designers designed and built hardware sketches in the form of playful shape- changing prototypes, generatively working with Rasmussen et al’s [31] eight unique types of shape change. Seeing that shape-changing ......In this paper we describe the outcomes from a design exercise in which eight groups of designers designed and built hardware sketches in the form of playful shape- changing prototypes, generatively working with Rasmussen et al’s [31] eight unique types of shape change. Seeing that shape...... for the further expansion of the design space of shape changing interfaces relating to the perception and understanding of behaviour, causality and the mechanics involved in shape change events, which we call “Imagined Physics.” This concept is described along with additional insights into the qualities of shape...

New Examples of Torsion-Free Non-unique Product Groups

OpenAIRE

Carter, William

2013-01-01

We give an infinite family of torsion-free groups that do not satisfy the unique product property. For these examples, we also show that each group contains arbitrarily large sets whose square has no uniquely represented element.

Unique Perspectives on a Transforming Energy Economy: 2014 Annual Report (Brochure)

Energy Technology Data Exchange (ETDEWEB)

Gossett, S. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2014-03-01

What makes JISEA unique? Unique perspectives. This brochure highlights the unique perspectives provided by the Joint Institute for Strategic Energy Analysis through JISEA's recent accomplishments and the people behind them.

The method of selecting an integrated development territory for the high-rise unique constructions

Directory of Open Access Journals (Sweden)

Sheina Svetlana

2018-01-01

Full Text Available On the basis of data provided by the Department of architecture and urban planning of the city of Rostov-on-don, the problem of the choice of the territory for complex development that will be in priority for the construction of high-rise and unique buildings is solved. The objective of the study was the development of a methodology for selection of the area and the implementation of the proposed method on the example of evaluation of four-territories complex development. The developed method along with standard indicators of complex evaluation considers additional indicators that assess the territory from the position of high-rise unique building. The final result of the study is the rankings of the functional priority areas that takes into account the construction of both residential and public and business objects of unique high-rise construction. The use of the developed methodology will allow investors and customers to assess the investment attractiveness of the future unique construction project on the proposed site.

Designing a Language Study.

Science.gov (United States)

Brown, James Dean

Some issues in the design of classroom research on second language teaching are discussed, with the intention of helping the researcher avoid conceptual pitfalls that may cripple the study later in the process. This begins with an examination of concerns in sampling, including definition of a population to be studied, alternative sampling…

PET-CT in the typification of unique pulmonary injuries

International Nuclear Information System (INIS)

Cobos, P.; San Roman, Jose L.; Dalurzo, L.

2007-01-01

The objective of this document is to evaluate the usefulness of the PET-CT for the characterization of the unique pulmonary injuries. Retrospective analysis was made to patients with unique pulmonary injuries who carried out a PET-CT in the Italian Hospital between May of 2003 - March of 2005. Those patients with pulmonary outlying nodule, or unique pulmonary mass that had pathological anatomy of injury or follow-up through a computed tomography of thorax made with an interval of time not minor at 2 years of the PET-CT were included [es

CONTEMPORARY USAGE OF TRADITIONAL TURKISH MOTIFS IN PRODUCT DESIGNS

Directory of Open Access Journals (Sweden)

Tulay Gumuser

2012-12-01

Full Text Available The aim of this study is to identify the traditional Turkish motifs and its relations among present industrial designs. Traditional Turkish motifs played a very important role in 16th century onwards. The arts of the Ottoman Empire were used because of their symbolic meanings and unique styles. When we examine these motifs we encounter; Tiger Stripe, Three Spot (Çintemani, Rumi, Hatayi, Penç, Cloud, Crescent, Star, Crown, Hyacinth, Tulip and Carnation motifs. Nowadays, Turkish designers have begun to use these traditional Turkish motifs in their designs so as to create differences and awareness in the world design. The examples of these industrial designs, using the Turkish motifs, have survived and have Ottoman heritage and historical value. In this study, the Turkish motifs will be examined along with their focus on contemporary Turkish industrial designs used today.

Lattices with unique complements

CERN Document Server

Saliĭ, V N

1988-01-01

The class of uniquely complemented lattices properly contains all Boolean lattices. However, no explicit example of a non-Boolean lattice of this class has been found. In addition, the question of whether this class contains any complete non-Boolean lattices remains unanswered. This book focuses on these classical problems of lattice theory and the various attempts to solve them. Requiring no specialized knowledge, the book is directed at researchers and students interested in general algebra and mathematical logic.

Methanophosphagen: Unique cyclic pyrophosphate isolated from Methanobacterium thermoautotrophicum

OpenAIRE

Kanodia, Sushila; Roberts, Mary Fedarko

1983-01-01

A unique cyclic pyrophosphate compound has been detected at 10-12 mM intracellular concentration in Methanobacterium thermoautotrophicum by in vivo31P NMR. This compound has been extracted from cells and purified by anion-exchange chromatography. Studies with 1H, 13C, and 31P NMR and fast-atom-bombardment mass spectrometry have identified it as 2,3-cyclopyrophosphoglycerate, an intramolecularly cyclized pyrophosphate of 2,3-diphosphoglycerate. Chemical degradation to 2,3-diphosphoglycerate an...

Exploratory Shaft Facility design basis study report

International Nuclear Information System (INIS)

Langstaff, A.L.

1987-01-01

The Design Basis Study is a scoping/sizing study that evaluated the items concerning the Exploratory Shaft Facility Design including design basis values for water and methane inflow; flexibility of the design to support potential changes in program direction; cost and schedule impacts that could result if the design were changed to comply with gassy mine regulations; and cost, schedule, advantages and disadvantages of a larger second shaft. Recommendations are proposed concerning water and methane inflow values, facility layout, second shaft size, ventilation, and gassy mine requirements. 75 refs., 3 figs., 7 tabs

Identity and privacy. Unique in the shopping mall: on the reidentifiability of credit card metadata.

Science.gov (United States)

de Montjoye, Yves-Alexandre; Radaelli, Laura; Singh, Vivek Kumar; Pentland, Alex Sandy

2015-01-30

Large-scale data sets of human behavior have the potential to fundamentally transform the way we fight diseases, design cities, or perform research. Metadata, however, contain sensitive information. Understanding the privacy of these data sets is key to their broad use and, ultimately, their impact. We study 3 months of credit card records for 1.1 million people and show that four spatiotemporal points are enough to uniquely reidentify 90% of individuals. We show that knowing the price of a transaction increases the risk of reidentification by 22%, on average. Finally, we show that even data sets that provide coarse information at any or all of the dimensions provide little anonymity and that women are more reidentifiable than men in credit card metadata. Copyright © 2015, American Association for the Advancement of Science.

Technology Transfer Challenges: A Case Study of User-Centered Design in NASA's Systems Engineering Culture

Science.gov (United States)

Quick, Jason

2009-01-01

The Upper Stage (US) section of the National Aeronautics and Space Administration's (NASA) Ares I rocket will require internal access platforms for maintenance tasks performed by humans inside the vehicle. Tasks will occur during expensive critical path operations at Kennedy Space Center (KSC) including vehicle stacking and launch preparation activities. Platforms must be translated through a small human access hatch, installed in an enclosed worksite environment, support the weight of ground operators and be removed before flight - and their design must minimize additional vehicle mass at attachment points. This paper describes the application of a user-centered conceptual design process and the unique challenges encountered within NASA's systems engineering culture focused on requirements and "heritage hardware". The NASA design team at Marshall Space Flight Center (MSFC) initiated the user-centered design process by studying heritage internal access kits and proposing new design concepts during brainstorming sessions. Simultaneously, they partnered with the Technology Transfer/Innovative Partnerships Program to research inflatable structures and dynamic scaffolding solutions that could enable ground operator access. While this creative, technology-oriented exploration was encouraged by upper management, some design stakeholders consistently opposed ideas utilizing novel, untested equipment. Subsequent collaboration with an engineering consulting firm improved the technical credibility of several options, however, there was continued resistance from team members focused on meeting system requirements with pre-certified hardware. After a six-month idea-generating phase, an intensive six-week effort produced viable design concepts that justified additional vehicle mass while optimizing the human factors of platform installation and use. Although these selected final concepts closely resemble heritage internal access platforms, challenges from the application of the

Design, development and performance study of six-gap glass MRPC detectors

Energy Technology Data Exchange (ETDEWEB)

Devi, M.M. [Tata Institute of Fundamental Research, Mumbai (India); Weizmann Institute of Science, Rehovot (Israel); Mondal, N.K.; Satyanarayana, B.; Shinde, R.R. [Tata Institute of Fundamental Research, Mumbai (India)

2016-12-15

The multigap resistive plate chambers (MRPCs) are gas ionization detectors with multiple gas sub-gaps made of resistive electrodes. The high voltage (HV) is applied on the outer surfaces of outermost resistive plates only, while the interior plates are left electrically floating. The presence of multiple narrow sub-gaps with high electric field results in faster signals on the outer electrodes, thus improving the detector's time resolution. Due to their excellent performance and relatively low cost, the MRPC detector has found potential application in time-of-flight (TOF) systems. Here we present the design, fabrication, optimization of the operating parameters such as the HV, the gas mixture composition, and, performance of six-gap glass MRPC detectors of area 27 cm x 27 cm, which are developed in order to find application as trigger detectors, in TOF measurement etc. The design has been optimized with unique spacers and blockers to ensure a proper gas flow through the narrow sub-gaps, which are 250 μm wide. The gas mixture consisting of R134A, Isobutane and SF{sub 6}, and the fraction of each constituting gases has been optimized after studying the MRPC performance for a set of different concentrations. The counting efficiency of the MRPC is about 95% at 17.9 kV. At the same operating voltage, the time resolution, after correcting for the walk effect, is found to be about 219 ps. (orig.)

[Reactance proneness, collectivism, uniqueness, and resistance to persuasion].

Science.gov (United States)

Imajo, Shuzo

2002-10-01

This study examined the reliability and validity of Japanese psychological reactance scales. A total of 167 undergraduates completed a questionnaire of Therapeutic Reactance Scale (TRS), the Hong Reactance Scale (HRS), the Uniqueness Scale, and the Collectivism Scale. They also received messages involving three persuasion situations that were either high or low in terms of threat, and were asked to describe their reactions to them. The author categorized the reactions into three: acceptance, indirect resistance, and direct resistance. Reliabilities of the reactance scales were satisfactory. Their scores positively correlated with uniqueness scores, and negatively with collectivism scores. Those high on reactance proneness were less persuaded in two of the three situations. But in the third, an HRS by threat interaction was observed, indicating that only those who were high on reactance proneness under the high-threat condition showed resistance to persuasion. These results suggest that the Japanese versions of reactance scale were reliable and valid. However, the assertiveness aspect of TRS may not be appropriate for the definition of reactance. The influence of culture on psychological reactance was also discussed.

Uniqueness of solutions for a mathematical model for magneto-viscoelastic flows

Science.gov (United States)

Schlömerkemper, A.; Žabenský, J.

2018-06-01

We investigate uniqueness of weak solutions for a system of partial differential equations capturing behavior of magnetoelastic materials. This system couples the Navier–Stokes equations with evolutionary equations for the deformation gradient and for the magnetization obtained from a special case of the micromagnetic energy. It turns out that the conditions on uniqueness coincide with those for the well-known Navier–Stokes equations in bounded domains: weak solutions are unique in two spatial dimensions, and weak solutions satisfying the Prodi–Serrin conditions are unique among all weak solutions in three dimensions. That is, we obtain the so-called weak-strong uniqueness result in three spatial dimensions.

Unique Description for Single Transverse Spin Asymmetries in DIS and Hadronic Collisions

International Nuclear Information System (INIS)

Yuan Feng

2007-01-01

We derive a unique formula for the single-transverse-spin asymmetry in semi-inclusive hadron production in deep inelastic scattering, valid for all transverse momentum region. Based on this, we further study the integrated asymmetry weighted with transverse-momentum. They can be evaluated in terms of the twist-three quark-gluon correlation functions, which are responsible for the single spin asymmetry in single inclusive hadron production in hadronic collisions. By using the fitted twist-three functions from the hadronic collision data, we find a consistent description for SSAs in deep inelastic scattering. This demonstrates that we have a unique picture for SSAs in these two processes, and shall provide important guidelines for future studies

Preliminary Design Study for a National Digital Seismograph Network

Science.gov (United States)

Peterson, Jon; Hutt, Charles R.

1981-01-01

. The NDSN system concept presented in this report is intended to serve as a point of discussion -- a strawman, if you will. It is a feasible solution to what we perceive to be the objectives of the NDSN, but it is not a unique solution. Current technology offers a variety of choices in meeting design objectives. We have examined some but not all of these choices. Although our fundamental concept of the NDSN is based on current technology, we have anticipated developments in several fields where state-of-the-art is evolving rapidly, notably satellite communications and database management. If the installation of the NDSN is delayed 5 - 10 years, we anticipate that the methods proposed to record, communicate, and manage the data may change, but it is likely that the fundamental data requirements will be the same. Therefore, in this study we have concentrated more on the types of data that will be generated at the NDSN stations and less on specific hardware that might be used in the data system. When the NDSN is budgeted, a second, more hardware-oriented design study may be needed.

A systematic review of protocol studies on conceptual design cognition: design as search and exploration

OpenAIRE

Hay, Laura; Duffy, Alex H.B.; McTeague, Chris; Pidgeon, Laura M.; Vuletic, Tijana; Grealy, Madeleine

2017-01-01

This paper reports findings from the first systematic review of protocol studies focusing specifically on conceptual design cognition, aiming to answer the following research question: What is our current understanding of the cognitive processes involved in conceptual design tasks carried out by individual designers? We reviewed 47 studies on architectural design, engineering design and product design engineering. This paper reports 24 cognitive processes investigated in a subset of 33 studie...

Uniqueness of the electrostatic solution in Schwarzschild space

International Nuclear Information System (INIS)

Molnar, Pal G.; Elsaesser, Klaus

2003-01-01

In this Brief Report we give the proof that the solution of any static test charge distribution in Schwarzschild space is unique. In order to give the proof we derive the first Green's identity written with p-forms on (pseudo) Riemannian manifolds. Moreover, the proof of uniqueness can be shown for either any purely electric or purely magnetic field configuration. The spacetime geometry is not crucial for the proof

Design study on advanced nuclear fuel recycle system. Conceptual design study of recycle system using molten salt

International Nuclear Information System (INIS)

Kasai, Y.; Kakehi, I.; Moro, T.; Higashi, T.; Tobe, K.; Kawamura, F.; Yonezawa, S.; Yoshiuji, T.

1998-10-01

Advanced recycle system engineering group of OEC (Oarai Engineering Center) has being carried out a design study of the advanced nuclear fuel recycle system using molten salt (electro-metallurgical process). This system is aiming for improvements of fuel cycle economy and reduction of environmental burden (MA recycles, Minimum of radioactive waste disposal), and also improvement of safety and nuclear non-proliferation. This report describes results of the design study that has been continued since December 1996. (1) A design concept of the advanced nuclear fuel recycle system, that is a module type recycles system of pyrochemical reprocessing and fuel re-fabrication was studied. The module system has advantage in balance of Pu recycle where modules are constructed in coincidence with the construction plan of nuclear power plants, and also has flexibility for technology progress. A demonstration system, minimum size of the above module, was studies. This system has capacity of 10 tHM/y and is able to demonstrate recycle technology of MOX fuel, metal fuel and nitride fuel. (2) Each process of the system, which are pyrochemical electrorefining system, cathode processor, de-cladding system, waste disposal system, etc., were studied. In this study, capacity of an electrorefiner was discussed, and vitrification experiment of molten salt using lead-boric acid glass was conducted. (3) A hot cell system and material handling system of the demonstration system was studied. A robot driven by linear motor was studied for the handling system, and an arrangement plan of the cell system was made. Criticality analysis in the cell system and investigation of material accountancy system of the recycle plant were also made. This design study will be continued in coincidence with design study of reactor and fuel, aiming to establish the concept of FBR recycle system. (author)

Design studies of Tokamak power reactor in JAERI

International Nuclear Information System (INIS)

Tone, T.; Nishikawa, M.; Tanaka, Y.

1985-01-01

Recent design studies of tokamak power reactor and related activities conducted in JAERI are presented. A design study of the SPTR (Swimming-Pool Type Reactor) concept was carried out in FY81 and FY82. The reactor design studies in the last two years focus on nuclear components, heat transport and energy conversion systems. In parallel of design studies, tokamak systems analysis code is under development to evaluate reactor performances, cost and net energy balance

DESTINY+ Trajectory Design to (3200) Phaethon

Science.gov (United States)

Sarli, Bruno Victorino; Horikawa, Makoto; Yam, Chit Hong; Kawakatsu, Yasuhiro; Yamamoto, Takayuki

2018-03-01

This work explores the target selection and trajectory design of the mission candidate for ISAS/JAXA's small science satellite series, DESTINY PLUS or DESTINY+. This mission combines unique aspects of the latest satellite technology and exploration of transition bodies to fill a technical and scientific gap in the Japanese space science program. The spacecraft is targeted to study the comet-asteroid transition body (3200) Phaethon through a combination of low-thrust propulsion and Earth Gravity Assist. The trajectory design concept is presented in details together with the launch window and flyby date analysis. Alternative targets for a possible mission extension scenario are also explored.

The household contact study design for genetic epidemiological studies of infectious diseases

Directory of Open Access Journals (Sweden)

Catherine eStein

2013-04-01

Full Text Available Most genetic epidemiological study designs fall into one of two categories: family-based and population-based (case-control. However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.

Within-culture variations of uniqueness: towards an integrative approach based on social status, gender, life contexts, and interpersonal comparison.

Science.gov (United States)

Causse, Elsa; Félonneau, Marie-Line

2014-01-01

Research on uniqueness is widely focused on cross-cultural comparisons and tends to postulate a certain form of within-culture homogeneity. Taking the opposite course of this classic posture, we aimed at testing an integrative approach enabling the study of within-culture variations of uniqueness. This approach considered different sources of variation: social status, gender, life contexts, and interpersonal comparison. Four hundred seventy-nine participants completed a measure based on descriptions of "self" and "other." Results showed important variations of uniqueness. An interaction between social status and life contexts revealed the expression of uniqueness in the low-status group. This study highlights the complexity of uniqueness that appears to be related to both cultural ideology and social hierarchy.

Infusing Technology Driven Design Thinking in Industrial Design Education: A Case Study

Science.gov (United States)

Mubin, Omar; Novoa, Mauricio; Al Mahmud, Abdullah

2017-01-01

Purpose: This paper narrates a case study on design thinking-based education work in an industrial design honours program. Student projects were developed in a multi-disciplinary setting across a Computing and Engineering faculty that allowed promoting technologically and user-driven innovation strategies. Design/methodology/approach: A renewed…

Multiple floating metatarsals: a unique injury

Directory of Open Access Journals (Sweden)

Trikha Vivek

2013-04-01

Full Text Available 【Abstract】Concomitant dislocation of the tar-sometatarsal and metatarsophalangeal joints of foot is an extremely rare injury. Such injuries presenting in a single or adjacent dual rays have been described in few cases previously. We describe such an injury in adjacent three metatarsals of a polytrauma patient. These injuries are likely to be missed in the initial assessment of a polytrauma patient. These patients are at risk of an overlooked diagnosis but the consequences of missing this type of injury may be Vivek Trikha*, Tarun Goyal, Amit K Agarwal quite severe. This case is presented in view of its unique-ness along with possible mechanism of injury, the sequence of reduction and follow-up. Knowledge of such injury and its proper management may be useful to the trauma surgeons. Key words: Metatarsal bones; Metatarsophalangeal joint; Wounds and injuries

Argonne Tau-charm factory collider design study

International Nuclear Information System (INIS)

Teng, L.C.; Crosbie, E.A.; Norem, J.

1995-01-01

The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper

Mirror Advanced Reactor Study interim design report

Energy Technology Data Exchange (ETDEWEB)

1983-04-01

The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design.

Mirror Advanced Reactor Study interim design report

International Nuclear Information System (INIS)

1983-04-01

The status of the design of a tenth-of-a-kind commercial tandem-mirror fusion reactor is described at the midpoint of a two-year study. When completed, the design is to serve as a strategic goal for the mirror fusion program. The main objectives of the Mirror Advanced Reactor Study (MARS) are: (1) to design an attractive tandem-mirror fusion reactor producing electricity and synfuels (in alternate versions), (2) to identify key development and technology needs, and (3) to exploit the potential of fusion for safety, low activation, and simple disposal of radioactive waste. In the first year we have emphasized physics and engineering of the central cell and physics of the end cell. Design optimization and trade studies are continuing, and we expect additional modifications in the end cells to further improve the performance of the final design

Classical many-particle systems with unique disordered ground states

Science.gov (United States)

Zhang, G.; Stillinger, F. H.; Torquato, S.

2017-10-01

Classical ground states (global energy-minimizing configurations) of many-particle systems are typically unique crystalline structures, implying zero enumeration entropy of distinct patterns (aside from trivial symmetry operations). By contrast, the few previously known disordered classical ground states of many-particle systems are all high-entropy (highly degenerate) states. Here we show computationally that our recently proposed "perfect-glass" many-particle model [Sci. Rep. 6, 36963 (2016), 10.1038/srep36963] possesses disordered classical ground states with a zero entropy: a highly counterintuitive situation . For all of the system sizes, parameters, and space dimensions that we have numerically investigated, the disordered ground states are unique such that they can always be superposed onto each other or their mirror image. At low energies, the density of states obtained from simulations matches those calculated from the harmonic approximation near a single ground state, further confirming ground-state uniqueness. Our discovery provides singular examples in which entropy and disorder are at odds with one another. The zero-entropy ground states provide a unique perspective on the celebrated Kauzmann-entropy crisis in which the extrapolated entropy of a supercooled liquid drops below that of the crystal. We expect that our disordered unique patterns to be of value in fields beyond glass physics, including applications in cryptography as pseudorandom functions with tunable computational complexity.

NASA GISS Climate Change Research Initiative: A Multidisciplinary Vertical Team Model for Improving STEM Education by Using NASA's Unique Capabilities.

Science.gov (United States)

Pearce, M. D.

2017-12-01

CCRI is a year-long STEM education program designed to bring together teams of NASA scientists, graduate, undergraduate and high school interns and high school STEM educators to become immersed in NASA research focused on atmospheric and climate changes in the 21st century. GISS climate research combines analysis of global datasets with global models of atmospheric, land surface, and oceanic processes to study climate change on Earth and other planetary atmospheres as a useful tool in assessing our general understanding of climate change. CCRI interns conduct research, gain knowledge in assigned research discipline, develop and present scientific presentations summarizing their research experience. Specifically, CCRI interns write a scientific research paper explaining basic ideas, research protocols, abstract, results, conclusion and experimental design. Prepare and present a professional presentation of their research project at NASA GISS, prepare and present a scientific poster of their research project at local and national research symposiums along with other federal agencies. CCRI Educators lead research teams under the direction of a NASA GISS scientist, conduct research, develop research based learning units and assist NASA scientists with the mentoring of interns. Educators create an Applied Research STEM Curriculum Unit Portfolio based on their research experience integrating NASA unique resources, tools and content into a teacher developed unit plan aligned with the State and NGSS standards. STEM Educators also Integrate and implement NASA unique units and content into their STEM courses during academic year, perform community education STEM engagement events, mentor interns in writing a research paper, oral research reporting, power point design and scientific poster design for presentation to local and national audiences. The CCRI program contributes to the Federal STEM Co-STEM initiatives by providing opportunities, NASA education resources and

Research design models: a new category

International Nuclear Information System (INIS)

Burgeson, D.A.

1983-01-01

This paper discusses the concept of a research design model and how it differs from an engineering design model. Essentially, the research design model draws on the methods, materials and processes of engineering design models but more emphasis is placed on conceptualization in 3-D. Typically, equipment and processes in research are unique. Often, there are competing concepts from which to decide. The approach which is evolving at Sandia National Laboratories mixes preliminary, engineering and research design on the same model

Accessibility of physical states and non-uniqueness of entanglement measure

International Nuclear Information System (INIS)

Morikoshi, Fumiaki; Santos, Marcelo Franca; Vedral, Vlatko

2004-01-01

Ordering physical states is the key to quantifying some physical property of the states uniquely. Bipartite pure entangled states are totally ordered under local operations and classical communication (LOCC) in the asymptotic limit and uniquely quantified by the well-known entropy of entanglement. However, we show that mixed entangled states are partially ordered under LOCC even in the asymptotic limit. Therefore, non-uniqueness of entanglement measure is understood on the basis of an operational notion of asymptotic convertibility

Conceptual design of laser fusion reactor, SENRI-I - 1. concept and system design

International Nuclear Information System (INIS)

Ido, S.; Naki, S.; Norimatsu, T.

1981-01-01

Design features of a laser fusion reactor concept SENRI-I and new concepts are reviewed and discussed. The unique feature is the utilization of a magnetic field to guide and control the inner liquid Li flow. Basic requirements and typical parameters used in the design are presented. Items to be discussed are constitution of the system, performance of liquid Li flow, neutronics, thermo-electric cycle, fuel cycle and new concepts

Multi-stability and variable stiffness of cellular solids designed based on origami patterns

Science.gov (United States)

Sengupta, Sattam; Li, Suyi

2017-04-01

The application of origami-inspired designs to engineered structures and materials has been a subject of much research efforts. These structures and materials, whose mechanical properties are directly related to the geometry of folding, are capable of achieving a host of unique adaptive functions. In this study, we investigate a three-dimensional multistability and variable stiffness function of a cellular solid based on the Miura-Ori folding pattern. The unit cell of such a solid, consisting of two stacked Miura-Ori sheets, can be elastically bistable due to the nonlinear relationship between rigid-folding deformation and crease material bending. Such a bistability possesses an unorthodox property: the critical, unstable configuration lies on the same side of two stable ones, so that two different force-deformation curves co-exist within the same range of deformation. By exploiting such unique stability properties, we can achieve a programmable stiffness change between the two elastically stable states, and the stiffness differences can be prescribed by tailoring the crease patterns of the cell. This paper presents a comprehensive parametric study revealing the correlations between such variable stiffness and various design parameters. The unique properties stemming from the bistability and design of such a unit cell can be advanced further by assembling them into a solid which can be capable of shape morphing and programmable mechanical properties.

Incorporation of unique molecular identifiers in TruSeq adapters improves the accuracy of quantitative sequencing.

Science.gov (United States)

Hong, Jungeui; Gresham, David

2017-11-01

Quantitative analysis of next-generation sequencing (NGS) data requires discriminating duplicate reads generated by PCR from identical molecules that are of unique origin. Typically, PCR duplicates are identified as sequence reads that align to the same genomic coordinates using reference-based alignment. However, identical molecules can be independently generated during library preparation. Misidentification of these molecules as PCR duplicates can introduce unforeseen biases during analyses. Here, we developed a cost-effective sequencing adapter design by modifying Illumina TruSeq adapters to incorporate a unique molecular identifier (UMI) while maintaining the capacity to undertake multiplexed, single-index sequencing. Incorporation of UMIs into TruSeq adapters (TrUMIseq adapters) enables identification of bona fide PCR duplicates as identically mapped reads with identical UMIs. Using TrUMIseq adapters, we show that accurate removal of PCR duplicates results in improved accuracy of both allele frequency (AF) estimation in heterogeneous populations using DNA sequencing and gene expression quantification using RNA-Seq.

Unique life sciences research facilities at NASA Ames Research Center

Science.gov (United States)

Mulenburg, G. M.; Vasques, M.; Caldwell, W. F.; Tucker, J.

1994-01-01

The Life Science Division at NASA's Ames Research Center has a suite of specialized facilities that enable scientists to study the effects of gravity on living systems. This paper describes some of these facilities and their use in research. Seven centrifuges, each with its own unique abilities, allow testing of a variety of parameters on test subjects ranging from single cells through hardware to humans. The Vestibular Research Facility allows the study of both centrifugation and linear acceleration on animals and humans. The Biocomputation Center uses computers for 3D reconstruction of physiological systems, and interactive research tools for virtual reality modeling. Psycophysiological, cardiovascular, exercise physiology, and biomechanical studies are conducted in the 12 bed Human Research Facility and samples are analyzed in the certified Central Clinical Laboratory and other laboratories at Ames. Human bedrest, water immersion and lower body negative pressure equipment are also available to study physiological changes associated with weightlessness. These and other weightlessness models are used in specialized laboratories for the study of basic physiological mechanisms, metabolism and cell biology. Visual-motor performance, perception, and adaptation are studied using ground-based models as well as short term weightlessness experiments (parabolic flights). The unique combination of Life Science research facilities, laboratories, and equipment at Ames Research Center are described in detail in relation to their research contributions.

Unique Capabilities of the Situational Awareness Sensor Suite for the ISS (SASSI) Mission Concept to Study the Equatorial Ionosphere

Science.gov (United States)

Habash Krause, L.; Gilchrist, B. E.; Minow, J. I.; Gallagher, D. L.; Hoegy, W. R.; Coffey, V. N.; Willis, E. M.

2014-12-01

We present an overview of a mission concept named Situational Awareness Sensor Suite for the ISS (SASSI) with a special focus here on low-latitude ionospheric plasma turbulence measurements relevant to equatorial spread-F. SASSI is a suite of sensors that improves Space Situational Awareness for the ISS local space environment, as well as unique ionospheric measurements and support active plasma experiments on the ISS. As such, the mission concept has both operational and basic research objectives. We will describe two compelling measurement techniques enabled by SASSI's unique mission architecture. That is, SASSI provides new abilities to 1) measure space plasma potentials in low Earth orbit over ~100 m relative to a common potential, and 2) to investigate multi-scale ionospheric plasma turbulence morphology simultaneously of both ~ 1 cm and ~ 10 m scale lengths. The first measurement technique will aid in the distinction of vertical drifts within equatorial plasma bubbles from the vertical motions of the bulk of the layer due to zonal electric fields. The second will aid in understanding ionospheric plasma turbulence cascading in scale sizes that affect over the horizon radar. During many years of ISS operation, we have conducted effective (but not perfect) human and robotic extravehicular activities within the space plasma environment surrounding the ISS structure. However, because of the complexity of the interaction between the ISS and the space environment, there remain important sources of unpredictable environmental situations that affect operations. Examples of affected systems include EVA safety, solar panel efficiency, and scientific instrument integrity. Models and heuristically-derived best practices are well-suited for routine operations, but when it comes to unusual or anomalous events or situations, there is no substitute for real-time monitoring. SASSI is being designed to deploy and operate a suite of low-cost, medium/high-TRL plasma sensors on

Argonne Tau-charm Factory collider design study

International Nuclear Information System (INIS)

Teng, L.C.; Crosbie, E.A.; Norem, J.; Repond, J.

1996-01-01

The design approach and design principles for a Tau-charm Factory at Argonne were studied. These studies led to a set of preliminary parameters and tentative component features as presented in this paper. copyright 1996 American Institute of Physics

Designing for Nomadic Play: A case study of participatory design with children

DEFF Research Database (Denmark)

Brynskov, Martin; Christensen, Bent Guldbjerg; Ludvigsen, Martin

This poster presents the results from an empirical probe study trying to engage children creatively in the design process of systems and artifacts that support nomadic life-style. Based on observational studies and interviews with children of different ages (5-15 years), we conducted a participat......This poster presents the results from an empirical probe study trying to engage children creatively in the design process of systems and artifacts that support nomadic life-style. Based on observational studies and interviews with children of different ages (5-15 years), we conducted...... a participatory design workshop cycle where children were encouraged to envision and virtually play with not-yet-invented future technology. Findings include qualitative characterizations of children’s activities (e.g. ‘play’ culture, use of digital media, age and gender differences, relation to space...

Combining several thermal indices to generate a unique heat comfort assessment methodology

Directory of Open Access Journals (Sweden)

Wissam EL Hachem

2015-11-01

Full Text Available Purpose: The proposed methodology hopes to provide a systematic multi-disciplinary approach to assess the thermal environment while minimizing unneeded efforts. Design/methodology/approach: Different factors affect the perception of the human thermal experience: metabolic rate (biology, surrounding temperatures (heat balance and environmental factors and cognitive treatment (physiology.This paper proposes a combination of different multidisciplinary variables to generate a unique heat comfort assessment methodology. The variables at stake are physiological, biological, and environmental. Our own heat analysis is thoroughly presented and all relevant equations are described. Findings: Most companies are oblivious about potential dangers of heat stress accidents and thus about methods to monitor and prevent them. This methodology enables the company or the concerned individual to conduct a preliminary assessment with minimal wasted resources and time in unnecessary steps whilst providing a guideline for a detailed study with minimal error rates if needed. More so, thermal comfort is an integral part of sound ergonomics practices, which in turn are decisive for the success of any lean six sigma initiative. Research limitations/implications: This methodology requires several full implementations to finalize its design. Originality/value: Most used heat comfort models are inherently uncertain and tiresome to apply. An extensive literature review confirms the need for a uniform assessment methodology that combines the different thermal comfort models such as the Fanger comfort model (PMV, PPD and WGBT since high error rates coupled with tiresome calculations often hinder the thermal assessment process.

Designing for hot-blade cutting

DEFF Research Database (Denmark)

Brander, David; Bærentzen, Jakob Andreas; Clausen, Kenn

2016-01-01

In this paper we present a novel method for the generation of doubly-curved, architectural design surfaces using swept Euler elastica and cubic splines. The method enables a direct design to production workflow with robotic hot-blade cutting, a novel robotic fabrication method under development......-trivial constraints of blade-cutting in a bottom-up fashion, enabling an exploration of the unique architectural potential of this fabrication approach. The method is implemented as prototype design tools in MatLAB, C++, GhPython, and Python and demonstrated through cutting of expanded polystyrene foam design...

Consciousness: a unique way of processing information.

Science.gov (United States)

Marchetti, Giorgio

2018-02-08

In this article, I argue that consciousness is a unique way of processing information, in that: it produces information, rather than purely transmitting it; the information it produces is meaningful for us; the meaning it has is always individuated. This uniqueness allows us to process information on the basis of our personal needs and ever-changing interactions with the environment, and consequently to act autonomously. Three main basic cognitive processes contribute to realize this unique way of information processing: the self, attention and working memory. The self, which is primarily expressed via the central and peripheral nervous systems, maps our body, the environment, and our relations with the environment. It is the primary means by which the complexity inherent to our composite structure is reduced into the "single voice" of a unique individual. It provides a reference system that (albeit evolving) is sufficiently stable to define the variations that will be used as the raw material for the construction of conscious information. Attention allows for the selection of those variations in the state of the self that are most relevant in the given situation. Attention originates and is deployed from a single locus inside our body, which represents the center of the self, around which all our conscious experiences are organized. Whatever is focused by attention appears in our consciousness as possessing a spatial quality defined by this center and the direction toward which attention is focused. In addition, attention determines two other features of conscious experience: periodicity and phenomenal quality. Self and attention are necessary but not sufficient for conscious information to be produced. Complex forms of conscious experiences, such as the various modes of givenness of conscious experience and the stream of consciousness, need a working memory mechanism to assemble the basic pieces of information selected by attention.

A Unique Sequence of Financial Accounting Courses Featuring Team Teaching, Linked Courses, Challenging Assignments, and Instruments for Evaluation and Assessment

Science.gov (United States)

Lundblad, Heidemarie; Wilson, Barbara A.

2008-01-01

The Department of Accounting at California State University Northridge (CSUN) has developed a unique sequence of courses designed to ensure that accounting students are trained not only in technical accounting, but also acquire critical thinking, research and communication skills. The courses have proven effective and have embedded assessment…

Cryostat design case studies, principles and engineering

CERN Document Server

2016-01-01

This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

Uniqueness and nonuniqueness for the porous medium equation with non linear boundary conditions

OpenAIRE

Cortazar, Carmen; Elgueta, Manuel; Rossi, Julio D.

2003-01-01

We study the uniqueness problem for nonnegative solutions of $u_t=\\Delta u^m$ in $\\Omega \\times [0,T)$, $-\\frac{\\partial u^m}{\\partial \\hat{n}}(x,t)=u^{\\lambda}(x,t)$ on $\\partial \\Omega \\times (0,T)$ and $u(x,0) \\equiv 0$ on $\\Omega$ where $m > 1$, $\\lambda \\ge 1$, and $\\Omega$ is a bounded domain with smooth boundary in $\\mathbf {R}^N$. We prove that the solution $u \\equiv 0$ is unique if and only if $2\\lambda \\geq m+1$.

Designs for mechanical circulatory support device studies.

Science.gov (United States)

Neaton, James D; Normand, Sharon-Lise; Gelijns, Annetine; Starling, Randall C; Mann, Douglas L; Konstam, Marvin A

2007-02-01

There is increased interest in mechanical circulatory support devices (MCSDs), such as implantable left ventricular assist devices (LVADs), as "destination" therapy for patients with advanced heart failure. Because patient availability to evaluate these devices is limited and randomized trials have been slow in enrolling patients, a workshop was convened to consider designs for MCSD development including alternatives to randomized trials. A workshop was jointly planned by the Heart Failure Society of America and the US Food and Drug Administration and was convened in March 2006. One of the panels was asked to review different designs for evaluating new MCSDs. Randomized trials have many advantages over studies with no controls or with nonrandomized concurrent or historical controls. These advantages include the elimination of bias in the assignment of treatments and the balancing, on average, of known and unknown baseline covariates that influence response. These advantages of randomization are particularly important for studies in which the treatments may not differ from one another by a large amount (eg, a head-to-head study of an approved LVAD with a new LVAD). However, researchers have found it difficult to recruit patients to randomized studies because the number of clinical sites that can carry out the studies is not large. Also, there is a reluctance to randomize patients when the control device is considered technologically inferior. Thus ways of improving the design of randomized trials were discussed, and the advantages and disadvantages of alternative designs were considered. The panel concluded that designs should include a randomized component. Randomized designs might be improved by allowing the control device to be chosen before randomization, by first conducting smaller vanguard studies, and by allowing crossovers in trials with optimal medical management controls. With use of data from completed trials, other databases, and registries, alternative

Alternative Design Study Report: WindPACT Advanced Wind Turbine Drive Train Designs Study; November 1, 2000 -- February 28, 2002

Energy Technology Data Exchange (ETDEWEB)

Poore, R.; Lettenmaier, T.

2003-08-01

This report presents the Phase I results of the National Renewable Energy Laboratory's (NREL's) WindPACT (Wind Partnership for Advanced Component Technologies) Advanced Wind Turbine Drive Train Designs Study. Global Energy Concepts, LLC performed this work under a subcontract with NREL. The purpose of the WindPACT project is to identify technology improvements that will enable the cost of energy (COE) from wind turbines to be reduced. Other parts of the WindPACT project have examined blade and logistics scaling, balance-of-station costs, and rotor design. This study was designed to investigate innovative drive train designs.

Basic principles of test-negative design in evaluating influenza vaccine effectiveness.

Science.gov (United States)

Fukushima, Wakaba; Hirota, Yoshio

2017-08-24

Based on the unique characteristics of influenza, the concept of "monitoring" influenza vaccine effectiveness (VE) across the seasons using the same observational study design has been developed. In recent years, there has been a growing number of influenza VE reports using the test-negative design, which can minimize both misclassification of diseases and confounding by health care-seeking behavior. Although the test-negative designs offer considerable advantages, there are some concerns that widespread use of the test-negative design without knowledge of the basic principles of epidemiology could produce invalid findings. In this article, we briefly review the basic concepts of the test-negative design with respect to classic study design such as cohort studies or case-control studies. We also mention selection bias, which may be of concern in some countries where rapid diagnostic testing is frequently used in routine clinical practices, as in Japan. Copyright © 2017. Published by Elsevier Ltd.

Design of unique pins for irradiation of higher actinides in a fast reactor

International Nuclear Information System (INIS)

Basmajian, J.A.; Birney, K.R.; Weber, E.T.; Adair, H.L.; Quinby, T.C.; Raman, S.; Butler, J.K.; Bateman, B.C.; Swanson, K.M.

1982-03-01

The actinides produced by transmutation reactions in nuclear reactor fuels are a significant factor in nuclear fuel burnup, transportation and reprocessing. Irradiation testing is a primary source of data of this type. A segmented pin design was developed which provides for incorporation of multiple specimens of actinide oxides for irradiation in the UK's Prototype Fast Reactor (PFR) at Dounreay Scotland. Results from irradiation of these pins will extend the basic neutronic and material irradiation behavior data for key actinide isotopes

280 GHz Gyro-BWO design study: Final report

International Nuclear Information System (INIS)

1988-07-01

This report summarizes the results of a design study of a 280 GHz Gyro-BWO tunable source. The purpose of this study is to identify and propose viable design alternatives for any significant technological risk associated with building an operational BWO system. The tunable Gyro-BWO system will have three major components: a Gyro-BWO microwave tube, a superconducting magnet, and a power supply/modulator. The design tasks for this study in order of decreasing importance are: design and specification of the superconducting magnet; preliminary design and layout of a Gyro-BWO microwave tube; and specification for the power supply/modulator. 2 refs., 4 figs

Mechanical System Analysis/Design Tool (MSAT) Quick Guide

Science.gov (United States)

Lee, HauHua; Kolb, Mark; Madelone, Jack

1998-01-01

MSAT is a unique multi-component multi-disciplinary tool that organizes design analysis tasks around object-oriented representations of configuration components, analysis programs and modules, and data transfer links between them. This creative modular architecture enables rapid generation of input stream for trade-off studies of various engine configurations. The data transfer links automatically transport output from one application as relevant input to the next application once the sequence is set up by the user. The computations are managed via constraint propagation - the constraints supplied by the user as part of any optimization module. The software can be used in the preliminary design stage as well as during the detail design of product development process.

Weeping dragon, a unique ornamenal citrus

Science.gov (United States)

‘Weeping Dragon’ is a new ornamental citrus cultivar developed by intercrossing of two unusual and unique citrus types, Poncirus trifoliata cultivated variety (cv.) Flying Dragon, and Citrus sinensis cv. ‘Cipo’. This new hybrid cultivar combines strongly contorted and weeping growth traits in a smal...

Learn from the Core--Design from the Core

Science.gov (United States)

Ockerse, Thomas

2012-01-01

The current objective, object-oriented approach to design is questioned along with design education viewed as a job-oriented endeavor. Instead relational knowledge and experience in a holistic sense, both tacit and explicit, are valued along with an appreciation of the unique character of the student. A new paradigm for design education is…

Loss of uniqueness in poro-mechanical model with enhanced media

International Nuclear Information System (INIS)

Sieffert, Y.; Marinelli, F.; Chambon, R.

2010-01-01

Document available in extended abstract form only. These paper deals with the problem of uniqueness in simulation the behavior of geo-materials with enhanced media to controlled the widths of bands. In the last 10 years, the loss of uniqueness has been clearly demonstrated in some initial boundary value problems involving constitutive equations modeling the degradation of the strength of materials. First in theoretical aspect with a simple test for a one dimensional problem of traction in a bar where the analytical solutions can be developed. In this article, It was also demonstrated that it is possible to retrieve all the analytical solutions in numerical simulations, only by using different starting guesses in the Newton's method. Then thanks to some classical numerical and experimental tests in geomechanical the non uniqueness is proved: the biaxial test and the borehole problem. However in all theses study, the geo-material is assumed to be monophasic. That's why is relevant to investigated the problem of uniqueness in taken into account the fluid part in the media. We deals in the framework of poro-mechanical model where the mechanical part is obeying a second gradient theory (not local) to ensure a regularization of the localisation pattern. This work is realized within the framework of the European Project TIMODAZ (Thermal Impact on the Damaged Zone Around a Radioactive Waste Disposal in Clay Host Rocks, http:// www.timodaz.eu/). As one benchmark in this project, the classical mechanical part is a Druecker-Prager model with a softening in the cohesion and a hardening in the frictional angle. It is a non-associated plasticity model for limited dilatancy. The parameters of this model are the same of this benchmark to simulated the Boom Clay material. Finally this paper demonstrates that several numerical solutions could be obtained as monophasic for the biaxial test modelling. (authors)

Fashion Research at Design Schools

DEFF Research Database (Denmark)

Skjold, Else

2008-01-01

on fashion education and fashion research, that are “taken for granted” in the institutional culture of each case. Because of the diversity between the cases, a cultural-oriented comparison has been made, where every case is perceived as idiographically unique (Thyge Winther-Jensen 2004). Descriptions......The report “Fashion Research at Design Schools” (2008), which was commissioned by Institute for Fashion and Textiles at Designskolen Kolding,  appoints the potentials and challenges in relation to the ongoing academization of design schools, with a specific focus on fashion research. The key...... research question is: “What kind of fashion design education is Designskolen Kolding aiming to offer in the future, what kind of skills will the students need in their future work place, the fashion industry, and can research work as a potential in this process?”   The study is based on qualitative...

Evaluating the effectiveness of Neuro web design model in business websites (observational study

Directory of Open Access Journals (Sweden)

Boshra Sedghi Shamir

2016-06-01

Full Text Available By combining Neuromarketing، social psychology and e-commerce، a new area has been added to the world of consumer neuroscience named Nero web design. The practical Neuro business web design model consists of 67 applicable and implementable techniques in business websites and has been gathered in three sequential phases: attraction، message delivery، and reshaping with the aim of negotiating to the visitor’s brain to increase the conversion rate on a business website. Eight websites have been implemented to evaluate the effectiveness of this model: A simple website without using the model، a complete website (using all 67 techniques in the model، and six other websites that differentiate in reshaping groups. The unique and targeted visitors for each websites obtained through internet advertisements. They became 957 new visitors altogether. In the period of two months of observational studying، Website heat maps that track the mouse movements of visitors، showed that visitors attracted to all parts of the complete website homepage particularly order form module but not so for the simple website. This reflects the success of attraction phase of the model. The results showed that the conversion rate of each of the seven model websites as compared to simple website is greatly high and even more than the international average conversion rate.

Stigma: a Unique Source of Distress for Family Members of Individuals with Mental Illness.

Science.gov (United States)

Muralidharan, Anjana; Lucksted, Alicia; Medoff, Deborah; Fang, Li Juan; Dixon, Lisa

2016-07-01

To distinguish the impact of mental illness stigma from that of other negative caregiving experiences, this study examined the unique relationships between stigma and caregiver/family functioning. Adult relatives (n = 437) of individuals with mental illness completed questionnaires regarding caregiving experiences, distress, empowerment, and family functioning, as part of a larger study. Regression analyses examined the relationship between stigma and caregiver/family variables, while controlling for other negative caregiving experiences. Stigma was uniquely associated with caregiver distress, empowerment, and family functioning. Mental illness stigma is a potent source of distress for families and an important target of family services.

Unique Associations between Peer Relations and Social Anxiety in Early Adolescence

Science.gov (United States)

Flanagan, Kelly S.; Erath, Stephen A.; Bierman, Karen L.

2008-01-01

This study examined the unique associations between feelings of social anxiety and multiple dimensions of peer relations (positive peer nominations, peer- and self-reported peer victimization, and self-reported friendship quality) among 383 sixth- and seventh-grade students. Hierarchical regression analysis provided evidence for the unique…

Schematic representation of case study research designs.

Science.gov (United States)

Rosenberg, John P; Yates, Patsy M

2007-11-01

The paper is a report of a study to demonstrate how the use of schematics can provide procedural clarity and promote rigour in the conduct of case study research. Case study research is a methodologically flexible approach to research design that focuses on a particular case - whether an individual, a collective or a phenomenon of interest. It is known as the 'study of the particular' for its thorough investigation of particular, real-life situations and is gaining increased attention in nursing and social research. However, the methodological flexibility it offers can leave the novice researcher uncertain of suitable procedural steps required to ensure methodological rigour. This article provides a real example of a case study research design that utilizes schematic representation drawn from a doctoral study of the integration of health promotion principles and practices into a palliative care organization. The issues discussed are: (1) the definition and application of case study research design; (2) the application of schematics in research; (3) the procedural steps and their contribution to the maintenance of rigour; and (4) the benefits and risks of schematics in case study research. The inclusion of visual representations of design with accompanying explanatory text is recommended in reporting case study research methods.

Nuclear-Powered GPS Spacecraft Design Study

Energy Technology Data Exchange (ETDEWEB)

Raab, Bernard

1977-05-01

This is the final report of a study to investigate the potential benefits of a nuclear (radioisotope) - powered satellite for advanced phases of the Global Positioning System (GPS) program. The critical parameters were: power to user; mean mission duration; orbital predictability; thermal control of on-board frequency standards; and vulnerability. The reference design approach is described, and input data are given for two power systems that are under development: an organic Rankine system and a Brayton cycle system. Reference design details are provided and structural design and analysis are discussed, as well as thermal design and analysis. A higher altitude version is also considered.

Mobile Variable Depth Sampling System Design Study

International Nuclear Information System (INIS)

BOGER, R.M.

2000-01-01

A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study

Mobile Variable Depth Sampling System Design Study

Energy Technology Data Exchange (ETDEWEB)

BOGER, R.M.

2000-08-25

A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study.

Common processes at unique volcanoes – a volcanological conundrum

OpenAIRE

Katharine eCashman; Juliet eBiggs

2014-01-01

An emerging challenge in modern volcanology is the apparent contradiction between the perception that every volcano is unique, and classification systems based on commonalities among volcano morphology and eruptive style. On the one hand, detailed studies of individual volcanoes show that a single volcano often exhibits similar patterns of behavior over multiple eruptive episodes; this observation has led to the idea that each volcano has its own distinctive pattern of behavior (or “personali...

Spot Pricing When Lagrange Multipliers Are Not Unique

DEFF Research Database (Denmark)

Feng, Donghan; Xu, Zhao; Zhong, Jin

2012-01-01

Classical spot pricing theory is based on multipliers of the primal problem of an optimal market dispatch, i.e., the solution of the dual problem. However, the dual problem of market dispatch may yield multiple solutions. In these circumstances, spot pricing or any standard pricing practice based...... on a strict extension of the principles of spot pricing and surplus allocation, we propose a new pricing methodology that can yield unique, impartial, and robust solution. The new method has been analyzed and compared with other pricing approaches in accordance with spot pricing theory. Case studies support...

Spreadsheet Design: An Optimal Checklist for Accountants

Science.gov (United States)

Barnes, Jeffrey N.; Tufte, David; Christensen, David

2009-01-01

Just as good grammar, punctuation, style, and content organization are important to well-written documents, basic fundamentals of spreadsheet design are essential to clear communication. In fact, the very principles of good writing should be integrated into spreadsheet workpaper design and organization. The unique contributions of this paper are…

Using network screening methods to determine locations with specific safety issues: A design consistency case study.

Science.gov (United States)

Butsick, Andrew J; Wood, Jonathan S; Jovanis, Paul P

2017-09-01

The Highway Safety Manual provides multiple methods that can be used to identify sites with promise (SWiPs) for safety improvement. However, most of these methods cannot be used to identify sites with specific problems. Furthermore, given that infrastructure funding is often specified for use related to specific problems/programs, a method for identifying SWiPs related to those programs would be very useful. This research establishes a method for Identifying SWiPs with specific issues. This is accomplished using two safety performance functions (SPFs). This method is applied to identifying SWiPs with geometric design consistency issues. Mixed effects negative binomial regression was used to develop two SPFs using 5 years of crash data and over 8754km of two-lane rural roadway. The first SPF contained typical roadway elements while the second contained additional geometric design consistency parameters. After empirical Bayes adjustments, sites with promise (SWiPs) were identified. The disparity between SWiPs identified by the two SPFs was evident; 40 unique sites were identified by each model out of the top 220 segments. By comparing sites across the two models, candidate road segments can be identified where a lack design consistency may be contributing to an increase in expected crashes. Practitioners can use this method to more effectively identify roadway segments suffering from reduced safety performance due to geometric design inconsistency, with detailed engineering studies of identified sites required to confirm the initial assessment. Copyright © 2017 Elsevier Ltd. All rights reserved.

Research on green building design based on ecological concept

Directory of Open Access Journals (Sweden)

Zhang Ping Qing

2016-01-01

Full Text Available At present, the protection of the ecological environment and the promotion of green building has been recognized and widely promoted.With the rapid development of the construction industry, Architecture design will inevitably require the resentation of its unique form and charm to reflect the ecological concept and ecological culture, because of the unique nature of the art and the particularity of the environment. To establish the ecological concept of green building design and vigorously develop the green green building has a complementary role to alleviate the pressure on resources,and to speed up the eco city planning design, and to realize the sustainable development of the city, and to protect the urban ecological environmental.

Design, construction and operation features of high-rise structures

Science.gov (United States)

Mylnik, Alexey; Mylnik, Vladimir; Zubeeva, Elena; Mukhamedzhanova, Olga

2018-03-01

The article considers design, construction and operation features of high-rise facilities. The analysis of various situations, that come from improper designing, construction and operation of unique facilities, is carried out. The integrated approach is suggested, when the problems of choosing acceptable constructional solutions related to the functional purpose, architectural solutions, methods of manufacturing and installation, operating conditions for unique buildings and structures are being tackled. A number of main causes for the emergency destruction of objects under construction and operation is considered. A number of measures are proposed on the basis of factor classification in order to efficiently prevent the situations, when various negative options of design loads and emergency impacts occur.

On uniqueness in evolution quasivariational inequalities

Czech Academy of Sciences Publication Activity Database

Brokate, M.; Krejčí, Pavel; Schnabel, H.

2004-01-01

Roč. 11, č. 1 (2004), s. 111-130 ISSN 0944-6532 Institutional research plan: CEZ:AV0Z1019905 Keywords : evolution quasivariational inequality * uniqueness * sweeping process Subject RIV: BA - General Mathematics Impact factor: 0.425, year: 2004 http://www.heldermann-verlag.de/jca/jca11/jca0386.pdf

Design Study for A Low-Cost LH2 Turbopump

Science.gov (United States)

Japikse, David; Baines, Nicholas; Platt, Michael J.

2000-01-01

A preliminary design study, focusing on potential component selections and design for manufacturing and assembly (DFMAR1) analysis, is presented in this study. The investigation focused on a nominal cost liquid hydrogen turbopump suitable for a private launch class vehicle. Utilizing a "turbocharger-like" design philosophy, preliminary feasibility studies of the basic pump design class, the rotordynamic design class, and the turbine design class were conducted with associated DFMA evaluations. Reasonable cost levels and sensible levels of product assurance have been established.

Unique Chernobyl Cranes for Deconstruction Activities in the New Safe Confinement - 13542

International Nuclear Information System (INIS)

Parameswaran, N.A. Vijay; Chornyy, Igor; Owen, Rob; Schmieman, Eric; Kedrowski, Dan

2013-01-01

The devastation left behind from the Chernobyl nuclear power plant (ChNPP) Unit 4 accident which occurred on April 26, 1986 presented unparalleled technical challenges to the world engineering and scientific community. One of the largest tasks that are in progress is the design and construction of the New Safe Confinement (NSC). The NSC is an engineered enclosure for the entire object shelter (OS) that includes a suite of process equipment. The process equipment will be used for the dismantling of the destroyed Chernobyl Nuclear Power Plant (ChNPP) Unit. One of the major mechanical handling systems to be installed in the NSC is the Main Cranes System (MCS). The planned decontamination and decommissioning or dismantling (D and D) activities will require the handling of heavily shielded waste disposal casks containing nuclear fuel as well as lifting and transporting extremely large structural elements. These activities, to be performed within the NSC, will require large and sophisticated cranes. The article will focus on the unique design features of the MCS for the D and D activities. (authors)

Unique Chernobyl Cranes for Deconstruction Activities in the New Safe Confinement - 13542

Energy Technology Data Exchange (ETDEWEB)

Parameswaran, N.A. Vijay [Bechtel Systems and Infrastructure, Inc. (United States); Chornyy, Igor [Chernobyl NPP-SIP-PMU (Ukraine); Owen, Rob [PaR Systems, Inc. (United States); Schmieman, Eric [Battelle Memorial Institute (United States); Kedrowski, Dan

2013-07-01

The devastation left behind from the Chernobyl nuclear power plant (ChNPP) Unit 4 accident which occurred on April 26, 1986 presented unparalleled technical challenges to the world engineering and scientific community. One of the largest tasks that are in progress is the design and construction of the New Safe Confinement (NSC). The NSC is an engineered enclosure for the entire object shelter (OS) that includes a suite of process equipment. The process equipment will be used for the dismantling of the destroyed Chernobyl Nuclear Power Plant (ChNPP) Unit. One of the major mechanical handling systems to be installed in the NSC is the Main Cranes System (MCS). The planned decontamination and decommissioning or dismantling (D and D) activities will require the handling of heavily shielded waste disposal casks containing nuclear fuel as well as lifting and transporting extremely large structural elements. These activities, to be performed within the NSC, will require large and sophisticated cranes. The article will focus on the unique design features of the MCS for the D and D activities. (authors)

Designing Adaptive Web Applications

DEFF Research Database (Denmark)

Dolog, Peter

2008-01-01

Learning system to study a discipline. In business to business interaction, different requirements and parameters of exchanged business requests might be served by different services from third parties. Such applications require certain intelligence and a slightly different approach to design. Adpative web......The unique characteristic of web applications is that they are supposed to be used by much bigger and diverse set of users and stakeholders. An example application area is e-Learning or business to business interaction. In eLearning environment, various users with different background use the e......-based applications aim to leave some of their features at the design stage in the form of variables which are dependent on several criteria. The resolution of the variables is called adaptation and can be seen from two perspectives: adaptation by humans to the changed requirements of stakeholders and dynamic system...

Common processes at unique volcanoes – a volcanological conundrum

Directory of Open Access Journals (Sweden)

Katharine eCashman

2014-11-01

Full Text Available An emerging challenge in modern volcanology is the apparent contradiction between the perception that every volcano is unique, and classification systems based on commonalities among volcano morphology and eruptive style. On the one hand, detailed studies of individual volcanoes show that a single volcano often exhibits similar patterns of behaviour over multiple eruptive episodes; this observation has led to the idea that each volcano has its own distinctive pattern of behaviour (or personality. In contrast, volcano classification schemes define eruption styles referenced to type volcanoes (e.g. Plinian, Strombolian, Vulcanian; this approach implicitly assumes that common processes underpin volcanic activity and can be used to predict the nature, extent and ensuing hazards of individual volcanoes. Actual volcanic eruptions, however, often include multiple styles, and type volcanoes may experience atypical eruptions (e.g., violent explosive eruptions of Kilauea, Hawaii1. The volcanological community is thus left with a fundamental conundrum that pits the uniqueness of individual volcanic systems against generalization of common processes. Addressing this challenge represents a major challenge to volcano research.

Holistic Leadership-Nursing's Unique Contribution to Healthcare.

Science.gov (United States)

Clarke, Pamela N; Bleich, Michael R

2018-04-01

This dialogue is focused on holistic leadership from the perspective of a well-known leader in nursing. He frames the changing healthcare environment and nursing's unique contribution on the interprofessional team.

48 CFR 52.211-7 - Alternatives to Government-unique standards.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Alternatives to Government... Government-unique standards. The offeror may propose voluntary consensus standards that meet the Government's... voluntary consensus standard instead of the Government-unique standard if it meets the Government's...

Linac design algorithm with symmetric segments

International Nuclear Information System (INIS)

Takeda, Harunori; Young, L.M.; Nath, S.; Billen, J.H.; Stovall, J.E.

1996-01-01

The cell lengths in linacs of traditional design are typically graded as a function of particle velocity. By making groups of cells and individual cells symmetric in both the CCDTL AND CCL, the cavity design as well as mechanical design and fabrication is simplified without compromising the performance. We have implemented a design algorithm in the PARMILA code in which cells and multi-cavity segments are made symmetric, significantly reducing the number of unique components. Using the symmetric algorithm, a sample linac design was generated and its performance compared with a similar one of conventional design

UNiquant, a Program for Quantitative Proteomics Analysis Using Stable Isotope Labeling

Energy Technology Data Exchange (ETDEWEB)

Huang, Xin; Tolmachev, Aleksey V.; Shen, Yulei; Liu, Miao; Huang, Lin; Zhang, Zhixin; Anderson, Gordon A.; Smith, Richard D.; Chan, Wing C.; Hinrichs, Steven; Fu, Kai; Ding, Shi-Jian

2011-03-04

We present UNiquant, a new software program for analyzing stable isotope labeling (SIL) based quantitative proteomics data. UNiquant surpassed the performance of two other platforms, MaxQuant and Mascot Distiller, using complex proteome mixtures having either known or unknown heavy/light ratios. UNiquant is compatible with a broad spectrum of search engines and SIL methods, providing outstanding peptide pair identification and accurate measurement of the relative peptide/protein abundance.

Unique Education and Workforce Development for NASA Engineers

Science.gov (United States)

Forsgren, Roger C.; Miller, Lauren L.

2010-01-01

NASA engineers are some of the world's best-educated graduates, responsible for technically complex, highly significant scientific programs. Even though these professionals are highly proficient in traditional analytical competencies, there is a unique opportunity to offer continuing education that further enhances their overall scientific minds. With a goal of maintaining the Agency's passionate, "best in class" engineering workforce, the NASA Academy of Program/Project & Engineering Leadership (APPEL) provides educational resources encouraging foundational learning, professional development, and knowledge sharing. NASA APPEL is currently partnering with the scientific community's most respected subject matter experts to expand its engineering curriculum beyond the analytics and specialized subsystems in the areas of: understanding NASA's overall vision and its fundamental basis, and the Agency initiatives supporting them; sharing NASA's vast reservoir of engineering experience, wisdom, and lessons learned; and innovatively designing hardware for manufacturability, assembly, and servicing. It takes collaboration and innovation to educate an organization that possesses such a rich and important historyand a future that is of great global interest. NASA APPEL strives to intellectually nurture the Agency's technical professionals, build its capacity for future performance, and exemplify its core valuesalJ to better enable NASA to meet its strategic visionand beyond.

Simulation of Unique Pressure Changing Steps and Situations in Psa Processes

Science.gov (United States)

Ebner, Armin D.; Mehrotra, Amal; Knox, James C.; LeVan, Douglas; Ritter, James A.

2007-01-01

A more rigorous cyclic adsorption process simulator is being developed for use in the development and understanding of new and existing PSA processes. Unique features of this new version of the simulator that Ritter and co-workers have been developing for the past decade or so include: multiple absorbent layers in each bed, pressure drop in the column, valves for entering and exiting flows and predicting real-time pressurization and depressurization rates, ability to account for choked flow conditions, ability to pressurize and depressurize simultaneously from both ends of the columns, ability to equalize between multiple pairs of columns, ability to equalize simultaneously from both ends of pairs of columns, and ability to handle very large pressure ratios and hence velocities associated with deep vacuum systems. These changes to the simulator now provide for unique opportunities to study the effects of novel pressure changing steps and extreme process conditions on the performance of virtually any commercial or developmental PSA process. This presentation will provide an overview of the cyclic adsorption process simulator equations and algorithms used in the new adaptation. It will focus primarily on the novel pressure changing steps and their effects on the performance of a PSA system that epitomizes the extremes of PSA process design and operation. This PSA process is a sorbent-based atmosphere revitalization (SBAR) system that NASA is developing for new manned exploration vehicles. This SBAR system consists of a 2-bed 3-step 3-layer system that operates between atmospheric pressure and the vacuum of space, evacuates from both ends of the column simultaneously, experiences choked flow conditions during pressure changing steps, and experiences a continuously changing feed composition, as it removes metabolic CO2 and H20 from a closed and fixed volume, i.e., the spacecraft cabin. Important process performance indicators of this SBAR system are size, and the

Observations from Space: A Unique Vantage Point for the Study of the Environment and Possible Associations with Disease Occurrence

Science.gov (United States)

Estes, S.; Haynes, J.; Hamdan, M. Al; Estes, M.; Sprigg, W.

2009-01-01

Health providers/researchers need environmental data to study and understand the geographic, environmental, and meteorological differences in disease. Satellite remote sensing of the environment offers a unique vantage point that can fill in the gaps of environmental, spatial, and temporal data for tracking disease. The field of geospatial health remains in its infancy, and this program will demonstrate the need for collaborations between multi-disciplinary research groups to develop the full potential. NASA will discuss the Public Health Projects developed to work with Grantees and the CDC while providing them with information on opportunities for future collaborations with NASA for future research.

Paired split-plot designs of multireader multicase studies.

Science.gov (United States)

Chen, Weijie; Gong, Qi; Gallas, Brandon D

2018-07-01

The widely used multireader multicase ROC study design for comparing imaging modalities is the fully crossed (FC) design: every reader reads every case of both modalities. We investigate paired split-plot (PSP) designs that may allow for reduced cost and increased flexibility compared with the FC design. In the PSP design, case images from two modalities are read by the same readers, thereby the readings are paired across modalities. However, within each modality, not every reader reads every case. Instead, both the readers and the cases are partitioned into a fixed number of groups and each group of readers reads its own group of cases-a split-plot design. Using a [Formula: see text]-statistic based variance analysis for AUC (i.e., area under the ROC curve), we show analytically that precision can be gained by the PSP design as compared with the FC design with the same number of readers and readings. Equivalently, we show that the PSP design can achieve the same statistical power as the FC design with a reduced number of readings. The trade-off for the increased precision in the PSP design is the cost of collecting a larger number of truth-verified patient cases than the FC design. This means that one can trade-off between different sources of cost and choose a least burdensome design. We provide a validation study to show the iMRMC software can be reliably used for analyzing data from both FC and PSP designs. Finally, we demonstrate the advantages of the PSP design with a reader study comparing full-field digital mammography with screen-film mammography.

RF microwave circuit design for wireless applications

CERN Document Server

Rohde, Ulrich L

2012-01-01

Provides researchers and engineers with a complete set of modeling, design, and implementation tools for tackling the newest IC technologies Revised and completely updated, RF/Microwave Circuit Design for Wireless Applications, Second Edition is a unique, state-of-the-art guide to wireless integrated circuit design that provides researchers and engineers with a complete set of modeling, design, and implementation tools for tackling even the newest IC technologies. It emphasizes practical design solutions for high-performance devices and circuitry, incorporating ample exa

Denture identification using unique identification authority of India barcode

OpenAIRE

Sudhindra Mahoorkar; Anoop Jain

2013-01-01

Over the years, various denture marking systems have been reported in the literature for personal identification. They have been broadly divided into surface marking and inclusion methods. In this technique, patient's unique identification number and barcode printed in the patient's Aadhaar card issued by Unique Identification Authority of India (UIDAI) are used as denture markers. This article describes a simple, quick, and economical method for identification of individual.

Denture identification using unique identification authority of India barcode.

Science.gov (United States)

Mahoorkar, Sudhindra; Jain, Anoop

2013-01-01

Over the years, various denture marking systems have been reported in the literature for personal identification. They have been broadly divided into surface marking and inclusion methods. In this technique, patient's unique identification number and barcode printed in the patient's Aadhaar card issued by Unique Identification Authority of India (UIDAI) are used as denture markers. This article describes a simple, quick, and economical method for identification of individual.

A Signal Detection Approach in a Multiple Cohort Study: Different Admission Tools Uniquely Select Different Successful Students

Directory of Open Access Journals (Sweden)

Linda van Ooijen-van der Linden

2018-05-01

Full Text Available Using multiple admission tools in university admission procedures is common practice. This is particularly useful if different admission tools uniquely select different subgroups of students who will be successful in university programs. A signal-detection approach was used to investigate the accuracy of Secondary School grade point average (SSGPA, an admission test score (ACS, and a non-cognitive score (NCS in uniquely selecting successful students. This was done for three consecutive first year cohorts of a broad psychology program. Each applicant's score on SSGPA, ACS, or NCS alone—and on seven combinations of these scores, all considered separate “admission tools”—was compared at two different (medium and high cut-off scores (criterion levels. Each of the tools selected successful students who were not selected by any of the other tools. Both sensitivity and specificity were enhanced by implementing multiple tools. The signal-detection approach distinctively provided useful information for decisions on admission instruments and cut-off scores.

[The values of different study designs on the levels of evidence: a descriptive analysis of the researches published in four general medical journals in 2009].

Science.gov (United States)

Yang, Zu-yao; Zhang, Yuan; Wu, Shan-shan; Zhou, Yuan; DU, Yu-kun; Zhan, Si-yan

2010-12-01

To discuss the levels of evidence provided by different study designs. Websites of N Engl J Med, JAMA, Lancet, and BMJ were accessed to identify research articles (systematic review and meta-analysis included) published in 2009. A standardized data collection form was established using Epidata 3.1 software to extract the "title", "country of lead author", "clinical problem" (such as treatment, diagnosis, etc.) and "study design" of eligible studies. Descriptive statistics was conducted with SPSS 13.0. Over all, 844 studies were included, among which 35.7% were RCT, 9.4% systematic review and Meta-analysis, and 54.9% other types of studies. Regarding clinical problems, 34.2%, 19.7%, 13.7%, 6.0% and 5.1% of the included researches addressed the issues of treatment, etiology/risk factors, prevention, disease frequency and prognosis, respectively. The study designs that were most frequently adopted to explore these problems were RCT (70.6%), cohort study (44.6%), RCT (68.1%), cross-sectional study (56.9%), and cohort study (93.0%), respectively. High-level evidence does not come exclusively from RCT and systematic review, as each type of study may have its unique value in health related research. The clinical problem of interest, the previous work that has been done to approach the same issue, as well as other factors should be taken into account when deciding whether the selected study design is appropriate.

Arab Teens Lifestyle Study (ATLS: objectives, design, methodology and implications

Directory of Open Access Journals (Sweden)

Musaiger AO; ATLS Research Group

2011-12-01

Full Text Available Hazzaa M Al-Hazzaa1,2, Abdulrahman O Musaiger3, ATLS Research Group1Exercise Physiology Laboratory, Department of Physical Education and Movement Sciences, College of Education, King Saud University, 2Scientific Board, Obesity Research Chair, King Saud University, Riyadh, Saudi Arabia; 3Arab Center for Nutrition, Manama, Bahrain, and Nutrition and Health Studies Unit, Deanship of Scientific Research, University of Bahrain, BahrainBackground: There is a lack of comparable data on physical activity, sedentary behavior, and dietary habits among Arab adolescents, which limits our understanding and interpretation of the relationship between obesity and lifestyle parameters. Therefore, we initiated the Arab Teens Lifestyle Study (ATLS. The ATLS is a multicenter collaborative project for assessing lifestyle habits of Arab adolescents. The objectives of the ATLS project were to investigate the prevalence rates for overweight and obesity, physical activity, sedentary activity and dietary habits among Arab adolescents, and to examine the interrelationships between these lifestyle variables. This paper reports on the objectives, design, methodology, and implications of the ATLS.Design/Methods: The ATLS is a school-based cross-sectional study involving 9182 randomly selected secondary-school students (14–19 years from major Arab cities, using a multistage stratified sampling technique. The participating Arab cities included Riyadh, Jeddah, and Al-Khobar (Saudi Arabia, Bahrain, Dubai (United Arab Emirates, Kuwait, Amman (Jordan, Mosel (Iraq, Muscat (Oman, Tunisia (Tunisia and Kenitra (Morocco. Measured variables included anthropometric measurements, physical activity, sedentary behavior, sleep duration, and dietary habits.Discussion: The ATLS project will provide a unique opportunity to collect and analyze important lifestyle information from Arab adolescents using standardized procedures. This is the first time a collaborative Arab project will

Controlled air incinerator conceptual design study

International Nuclear Information System (INIS)

1982-01-01

This report presents a conceptual design study for a controlled air incinerator facility for incineration of low level combustible waste at Three Mile Island Unit 2 (TMI-2). The facility design is based on the use of a Helix Process Systems controlled air incinerator. Cost estimates and associated engineering, procurement, and construction schedules are also provided. The cost estimates and schedules are presented for two incinerator facility designs, one with provisions for waste ash solidification, the other with provisions for packaging the waste ash for transport to an undefined location

Hot trends in design : chic sustainability, unique driving factors and boutique green roofs

Energy Technology Data Exchange (ETDEWEB)

Velazquez, L.S. [American Society of Landscape Architects, Washington, DC (United States)]|[Greenroofs.com, Alpharetta, GA (United States); Kiers, K. [Greenroofs.com, Alpharetta, GA (United States)

2007-07-01

Green roofs are well known for their ecological benefits but less for their architectural usage. Green roofs offer more to the urban landscape than simply ecological, economic and aesthetic attributes of storm water management, temperature and energy reduction, and provision of additional green space. This paper focused on the top ten architectural trends in vegetated rooftop design. It addressed issues regarding client demands for green roofs and questioned if green roofs should be defined solely by their function as an ecological cover. The top ten trends revealed out-of-the ordinary applications, specialty designs and unusual projects on the boards. The paper looked beyond storm water and heat islands, and explored plans for innovative recreation, including a rooftop ski slope in Delft, the Netherlands, and a converted helipad turned into temporary grass tennis court in Dubai. The paper also presented less typical green roof market drivers, such as a doggie green space for a 10-year old, 9-pound Yorkie and a rooftop garden with plants from the Bible as a teaching laboratory for ministers. Other proposed projects that were discussed included plans for rice paddies on rooftop farms in China and the Vancouver Olympic Village with 50 per cent green roof coverage. The top ten list was organized under the following topics: boutique green roofs; sports and recreation; living roofs and living walls; eco resorts, hotels and therapeutic gardens; food on the roof; cutting edge applications; government and big box applications, cool green residences; mega green roofs; and, visionary proposed projects. 77 refs., 77 figs.

The uniqueness of the solution for the definite problem of a parabolic variational inequality

Directory of Open Access Journals (Sweden)

Liping Song

2016-12-01

Full Text Available Abstract The uniqueness of the solution for the definite problem of a parabolic variational inequality is proved. The problem comes from the study of the optimal exercise strategies for the perpetual executive stock options with unrestricted exercise in financial market. Because the variational inequality is degenerate and the obstacle condition contains the partial derivative of an unknown function, it makes the theoretical study of the definite problem of the variational inequality problem very difficult. Firstly, the property which the value function satisfies is derived by applying the Jensen inequality. Then the uniqueness of the solution is proved by using this property and maximum principles.

Implementing a Mobile Social Media Framework for Designing Creative Pedagogies

Directory of Open Access Journals (Sweden)

Thomas Cochrane

2014-08-01

Full Text Available The rise of mobile social media provides unique opportunities for new and creative pedagogies. Pedagogical change requires a catalyst, and we argue that mobile social media can be utilized as such a catalyst. However, the mobile learning literature is dominated by case studies that retrofit traditional pedagogical strategies and pre-existing course activities onto mobile devices and social media. From our experiences of designing and implementing a series of mobile social media projects, the authors have developed a mobile social media framework for creative pedagogies. We illustrate the implementation of our mobile social media framework within the development of a new media minor (an elective set of four courses that explicitly integrates the unique technical and pedagogical affordances of mobile social media, with a focus upon student-generated content and student-determined learning (heutagogy. We argue that our mobile social media framework is potentially transferable to a range of educational contexts, providing a simple design framework for new pedagogies.

Digital Art and Design

OpenAIRE

Batiha, Khaled; Al Salaimeh, Safwan; Besoul, Khaldoun

2007-01-01

The desire to create unique things and give free rain to one's imagination served as a powerful impetus to the development of digital art and design software. The commoner was the use of computers the wider variety of professional software was developed. Nowadays the creators and computer designers are receiving more and more new and advanced programs that allow their ideas becoming virtual reality. This research paper looks at the history of the development of graphic editors from the simple...

No Need to Wait for Superman: A Case Study of One Unique High School

Science.gov (United States)

Ratcliff, N. J.; Jones, C. R.; Costner, R. H.; Knight, C.; Disney, G.; Savage-Davis, E.; Sheehan, H.; Hunt, G. H.

2012-01-01

Based on a theoretical model developed by Schlechty, this case study focuses on a small high school, located on a college campus and designed to address the educational needs of gifted 9th- through 12th-grade students. Eight teachers who taught 9th- and 12th-grade classes and their 60 students were observed. Each teacher was observed during six…

Aircraft Design Software

Science.gov (United States)

1997-01-01

Successful commercialization of the AirCraft SYNThesis (ACSYNT) tool has resulted in the creation of Phoenix Integration, Inc. ACSYNT has been exclusively licensed to the company, an outcome of a seven year, $3 million effort to provide unique software technology to a focused design engineering market. Ames Research Center formulated ACSYNT and in working with the Virginia Polytechnic Institute CAD Laboratory, began to design and code a computer-aided design for ACSYNT. Using a Joint Sponsored Research Agreement, Ames formed an industry-government-university alliance to improve and foster research and development for the software. As a result of the ACSYNT Institute, the software is becoming a predominant tool for aircraft conceptual design. ACSYNT has been successfully applied to high- speed civil transport configuration, subsonic transports, and supersonic fighters.

Guide to good practices for operations aspects of unique processes

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-01

This Guide to Good Practices is written to enhance understanding of, and provide direction for, Operations Aspects of Facility Chemistry and Unique Processes, Chapter XIII of Department of Energy (DOE) Order 5480.19, Conduct of Operations Requirements for DOE Facilities. The practices in this guide should be considered when planning or reviewing employee training and facility management programs. Contractors are advised to adopt procedures that meet the intent of DOE Order 5480.19. Operations Aspects of Unique Processes is an element of an effective Conduct of Operations program. The complexity and array of activities performed in DOE facilities dictate the necessity for all personnel to coordinate interrelated activities affecting unique processes.

A study on the development of an infographic designer questionnaire and designer opinions

Directory of Open Access Journals (Sweden)

Yıldırım Serkan

2016-01-01

Full Text Available Technological developments and changes in how learning is understood have not only changed learning environments, but also how educational materials are developed. Infographics, one of the materials that are becoming increasingly more popular in learning environments, have nowadays become quite commonplace. Demonstrating the understanding of those who design such instructional materials is important with respect to the organisation of learning processes. In this study, we devised a questionnaire that aims to demonstrate the understanding infographic designers have of infographic design. A total of 94 students from the Department of Computer and Instructional Technologies Education of the Kazım Karabekir Faculty of Education took part in this study conducted during the fall semester of the 2013–2014 academic year. The participants were given a questionnaire consisting of 41 items that enquired about the readers’ views regarding infographic design. The collected data were assessed using Principal Component Analysis. Based on the analysis results, a questionnaire form consisting of 27 items and 8 factors (Understanding of Design, Design Process, Copyrights, Introduction, Readability, Sharing, References, Development was developed.

Verification of the Barnwell Nuclear Fuel Plant (BNFP) mechanical headend design

International Nuclear Information System (INIS)

Townes, G.A.

1978-11-01

Design of the Barnwell Nuclear Fuel Plant mechanical head end includes unique provisions for remote maintenance, minimizes remote handling, and permits high throughput (6 MTU of spent fuel per day). Operability studies have been performed under a contract with the Department of Energy that: (1) assessed its capabilities for possible use in fuel encapsulation with or without compaction as a preparation for spent fuel storage, (2) verified the design of the mechanical head end as remotely maintainable, and (3) provided operator training

Additive manufacturing of metals the technology, materials, design and production

CERN Document Server

Yang, Li; Baughman, Brian; Godfrey, Donald; Medina, Francisco; Menon, Mamballykalathil; Wiener, Soeren

2017-01-01

This book offers a unique guide to the three-dimensional (3D) printing of metals. It covers various aspects of additive, subtractive, and joining processes used to form three-dimensional parts with applications ranging from prototyping to production. Examining a variety of manufacturing technologies and their ability to produce both prototypes and functional production-quality parts, the individual chapters address metal components and discuss some of the important research challenges associated with the use of these technologies. As well as exploring the latest technologies currently under development, the book features unique sections on electron beam melting technology, material lifting, and the importance this science has in the engineering context. Presenting unique real-life case studies from industry, this book is also the first to offer the perspective of engineers who work in the field of aerospace and transportation systems, and who design components and manufacturing networks. Written by the leadin...

Attitude Certainty and Attitudinal Advocacy: The Unique Roles of Clarity and Correctness.

Science.gov (United States)

Cheatham, Lauren; Tormala, Zakary L

2015-11-01

When and why do people advocate on behalf of their attitudes? Past research suggests that attitude certainty is one important determinant. The current research seeks to provide more nuanced insight into this relationship by (a) exploring the unique roles of attitude clarity and attitude correctness, and (b) mapping clarity and correctness onto different forms of advocacy (sharing intentions and persuasion intentions). Across four studies, we find that correctness but not clarity plays an important role in promoting persuasion intentions, whereas both correctness and clarity help shape sharing intentions. Thus, this research unpacks the certainty-advocacy relation and helps identify experimental manipulations that uniquely drive persuasion and sharing intentions. © 2015 by the Society for Personality and Social Psychology, Inc.

Conceptual study of advanced PWR core design

International Nuclear Information System (INIS)

Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong.

1997-09-01

The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs

Conceptual study of advanced PWR core design

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong

1997-09-01

The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs.

Rationality, irrationality and escalating behavior in lowest unique bid auctions.

Science.gov (United States)

Radicchi, Filippo; Baronchelli, Andrea; Amaral, Luís A N

2012-01-01

Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions--lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of "bid space". The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets.

Antiproliferative Effects of Bacillus coagulans Unique IS2 in Colon Cancer Cells.

Science.gov (United States)

Madempudi, Ratna Sudha; Kalle, Arunasree M

2017-10-01

In the present study, the in vitro anticancer (antiproliferative) effects of Bacillus coagulans Unique IS2 were evaluated on human colon cancer (COLO 205), cervical cancer (HeLa), and chronic myeloid leukemia (K562) cell lines with a human embryonic kidney cell line (HEK 293T) as noncancerous control cells. The Cytotoxicity assay (MTT) clearly demonstrated a 22%, 31.7%, and 19.5% decrease in cell proliferation of COLO 205, HeLa, and K562 cells, respectively, when compared to the noncancerous HEK 293T cells. Normal phase-contrast microscopic images clearly suggested that the mechanism of cell death is by apoptosis. To further confirm the induction of apoptosis by Unique IS2, the sub-G0-G1 peak of the cell cycle was quantified using a flow cytometer and the data indicated 40% of the apoptotic cells in Unique IS2-treated COLO cells when compared with their untreated control cells. The Western blot analysis showed an increase in pro-apoptotic protein BAX, decrease in antiapoptotic protein, Bcl2, decrease in mitochondrial membrane potential, increase in cytochrome c release, increase in Caspase 3 activity, and cleavage of poly(ADP-ribose) polymerase. The present study suggests that the heat-killed culture supernatant of B. coagulans can be more effective in inducing apoptosis of colon cancer cells and that can be considered for adjuvant therapy in the treatment of colon carcinoma.

Class 1 devices case studies in medical devices design

CERN Document Server

Ogrodnik, Peter J

2014-01-01

The Case Studies in Medical Devices Design series consists of practical, applied case studies relating to medical device design in industry. These titles complement Ogrodnik's Medical Device Design and will assist engineers with applying the theory in practice. The case studies presented directly relate to Class I, Class IIa, Class IIb and Class III medical devices. Designers and companies who wish to extend their knowledge in a specific discipline related to their respective class of operation will find any or all of these titles a great addition to their library. Class 1 Devices is a companion text to Medical Devices Design: Innovation from Concept to Market. The intention of this book, and its sister books in the series, is to support the concepts presented in Medical Devices Design through case studies. In the context of this book the case studies consider Class I (EU) and 510(k) exempt (FDA) . This book covers classifications, the conceptual and embodiment phase, plus design from idea to PDS. These title...

Mechanical design of a lidar system for space applications - LITE

Science.gov (United States)

Crockett, Sharon K.

1990-01-01

The Lidar In-Space Technology Experiment (LITE) is a Shuttle experiment that will demonstrate the first use of a lidar system in space. Its design process must take into account not only the system design but also the unique design requirements for spaceborne experiment.

Design development of graphite primary structures enables SSTO success

Science.gov (United States)

Biagiotti, V. A.; Yahiro, J. S.; Suh, Daniel E.; Hodges, Eric R.; Prior, Donald J.

1997-01-01

This paper describes the development of a graphite composite wing and a graphite composite intertank primary structure for application toward Single-Stage to Orbit space vehicles such as those under development in NASA's X-33/Reusable Launch Vehicle (RLV) Program. The trade study and designs are based on a Rockwell vertical take-off and horizontal landing (VTHL) wing-body RLV vehicle. Northrop Grumman's approach using a building block development technique is described. Composite Graphite/Bismaleimide (Gr/BMI) material characterization test results are presented. Unique intertank and wing composite subcomponent test article designs are described and test results to date are presented. Wing and intertank Full Scale Section Test Article (FSTA) objectives and designs are outlined. Trade studies, supporting building block testing, and FSTA demonstrations combine to develop graphite primary structure composite technology that enables developing X-33/RLV design programs to meet critical SSTO structural weight and operations performance criteria.

CALCULATION OF THE UNIQUE HIGH-RISE BUILDING FOR EARTHQUAKES IN NONLINEAR DYNAMIC FORMULATION

Directory of Open Access Journals (Sweden)

Mkrtychev Oleg Vartanovich

2016-06-01

Full Text Available The article contains the calculation of a 80-storey high-rise building on 3-component accelerograms with different dominant frequencies. The “Akhmat Tower” belongs to the complex “Grozny-city 2” and is classified as a unique construction, its height is 400 m. During the construction unique high-rise buildings and high-rise buildings in seismic areas an additional computational studies are required, which should take into account the nonlinear nature of the design. For the case of linear instrumental-synthesized accelerograms, it is necessary to apply nonlinear dynamic methods. The studies were conducted using the software LS-DYNA, implementing the methods of direct integration of the equations of motion by the explicit scheme. The constructive scheme of the building frame is braced, the spatial stability is ensured by load-bearing interior walls, columns and hard disks, and frame metal coatings. The choice of the type and dimensions of the finite element and the step of integration is due to the ability to perform calculations in reasonable time, and to the required accuracy of calculation. For this aim the issues of convergence of the solutions on a number of settlement schemes were investigated with the terms of thickened mesh of finite elements: 0.5 m; 1 m; 2 m; 3 m. As a result of the research it was obtained that the best is to split into finite elements with a characteristic size of 2 m. The calculation of the building is made on rigid foundation. The authors used accelerograms normalized for earthquakes of 8 and 9 points on the MSK-64 scale. The destruction of the elements in the process of loading, and the interaction of the elements during their contact was taken into account, i.e. the calculation was made taking into account physical, geometrical and structural nonlinearities. The article analyzes the results of the calculation. The authors evaluated the seismic stability of the building. Possible ways to improve the seismic

Gaps in the Design Process

Energy Technology Data Exchange (ETDEWEB)

Veers, Paul

2016-10-04

The design of offshore wind plants is a relatively new field. The move into U.S. waters will have unique environmental conditions, as well as expectations from the authorities responsible for managing the development. Wind turbines are required to test their assumed design conditions with the site conditions of the plant. There are still some outstanding issues on how we can assure that the design for both the turbine and the foundation are appropriate for the site and will have an acceptable level of risk associated with the particular installation.

Fundamentals of IP and SoC security design, verification, and debug

CERN Document Server

Ray, Sandip; Sur-Kolay, Susmita

2017-01-01

This book is about security in embedded systems and it provides an authoritative reference to all aspects of security in system-on-chip (SoC) designs. The authors discuss issues ranging from security requirements in SoC designs, definition of architectures and design choices to enforce and validate security policies, and trade-offs and conflicts involving security, functionality, and debug requirements. Coverage also includes case studies from the “trenches” of current industrial practice in design, implementation, and validation of security-critical embedded systems. Provides an authoritative reference and summary of the current state-of-the-art in security for embedded systems, hardware IPs and SoC designs; Takes a "cross-cutting" view of security that interacts with different design and validation components such as architecture, implementation, verification, and debug, each enforcing unique trade-offs; Includes high-level overview, detailed analysis on implementation, and relevant case studies on desi...

The spatial distribution of otosclerosis: a quantitative study using design-based stereology

DEFF Research Database (Denmark)

Bloch, Sune Land; Sørensen, Mads Sølvsten

2010-01-01

This study documents that otosclerotic bone remodeling is distributed centripetally around the inner ear space whereas normal bone remodeling is distributed centrifugally. We suggest that this inverse relation reflects the unique osteo-dynamic setting of the otic capsule: since perilabyrinthine...

The spatial distribution of otosclerosis: a quantitative study using design-based stereology

DEFF Research Database (Denmark)

Bloch, Sune Land; Sørensen, Mads Sølvsten

2010-01-01

This study documents that otosclerotic bone remodeling is distributed centripetally around the inner ear space whereas normal bone remodeling is distributed centrifugally. We suggest that this inverse relation reflects the unique osteo-dynamic setting of the otic capsule: since perilabyrinthine b...

Control system design guide

Energy Technology Data Exchange (ETDEWEB)

Sellers, David; Friedman, Hannah; Haasl, Tudi; Bourassa, Norman; Piette, Mary Ann

2003-05-01

The ''Control System Design Guide'' (Design Guide) provides methods and recommendations for the control system design process and control point selection and installation. Control systems are often the most problematic system in a building. A good design process that takes into account maintenance, operation, and commissioning can lead to a smoothly operating and efficient building. To this end, the Design Guide provides a toolbox of templates for improving control system design and specification. HVAC designers are the primary audience for the Design Guide. The control design process it presents will help produce well-designed control systems that achieve efficient and robust operation. The spreadsheet examples for control valve schedules, damper schedules, and points lists can streamline the use of the control system design concepts set forth in the Design Guide by providing convenient starting points from which designers can build. Although each reader brings their own unique questions to the text, the Design Guide contains information that designers, commissioning providers, operators, and owners will find useful.

Apixaban for the Secondary Prevention of Thrombosis Among Patients With Antiphospholipid Syndrome: Study Rationale and Design (ASTRO-APS).

Science.gov (United States)

Woller, Scott C; Stevens, Scott M; Kaplan, David A; Branch, D Ware; Aston, Valerie T; Wilson, Emily L; Gallo, Heather M; Johnson, Eric G; Rondina, Matthew T; Lloyd, James F; Evans, R Scott; Elliott, C Gregory

2016-04-01

Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by thrombosis, pregnancy morbidity, and the presence of characteristic antibodies. Current therapy for patients having APS with a history of thrombosis necessitates anticoagulation with the vitamin K antagonist warfarin, a challenging drug to manage. Apixaban, approved for the treatment and prevention of venous thrombosis with a low rate of bleeding observed, has never been studied among patients with APS. We report study rationale and design of Apixaban for the Secondary Prevention of Thrombosis Among Patients With Antiphospholipid Syndrome (ASTRO-APS), a prospective randomized open-label blinded event pilot study that will randomize patients with a clinical diagnosis of APS receiving therapeutic anticoagulation to either adjusted-dose warfarin or apixaban 2.5 mg twice a day. We aim to report our ability to identify, recruit, randomize, and retain patients with APS randomized to apixaban compared with warfarin. We will report clinically important outcomes of thrombosis and bleeding. All clinical outcomes will be adjudicated by a panel blinded to the treatment arm. A unique aspect of this study is the enrollment of patients with an established clinical diagnosis of APS. Also unique is our use of electronic medical record interrogation techniques to identify patients who would likely meet our inclusion criteria and use of an electronic portal for follow-up visit data capture. ASTRO-APS will be the largest prospective study to date comparing a direct oral anticoagulant with warfarin among patients with APS for the secondary prevention of thrombosis. Our inclusion criteria assure that outcomes obtained will be clinically applicable to the routine management of patients with APS receiving indefinite anticoagulation. © The Author(s) 2015.

Seismic design ampersand analysis considerations for high level nuclear waste repositories

International Nuclear Information System (INIS)

Hossain, Q.A.

1993-01-01

A high level nuclear waste repository, like the one at Nevada's Yucca Mountain that is being investigated for site suitability, will have some unique seismic design and analysis considerations. These are discussed, and a design philosophy that can rationally account for the unique performance objectives of such facilities is presented. A case is made for the use of DOE's performance goal-based seismic design and evaluation methodology that is based on a hybrid open-quotes deterministicclose quotes and open-quotes probabilisticclose quotes concept. How and to what extent this methodology should be modified to adopt it for a potential site like Yucca Mountain is also outlined. Finally, the issue of designing for seismic fault rupture is discussed briefly, and the desirability of using the proposed seismic design philosophy in fault rupture evaluation is described

Seismic design and analysis considerations for high level nuclear waste repositories

International Nuclear Information System (INIS)

Hossain, Q.A.

1993-01-01

A high level nuclear waste repository, like the one at Nevada's Yucca Mountain that is being investigated for site suitability, will have some unique seismic design and analysis considerations. These are discussed, and a design philosophy that can rationally account for the unique performance objectives of such facilities is presented. A case is made for the use of DOE's performance goal-based seismic design and evaluation methodology that is based on a hybrid ''deterministic'' and ''probabilistic'' concept. How and to what extent this methodology should be modified to adopt it for a potential site like Yucca Mountain is also outlined. Finally, the issue of designing for seismic fault rupture is discussed briefly, and the desirability of using the proposed seismic design philosophy in fault rupture evaluation is described

Engineering study for ISSTRS design concept

Energy Technology Data Exchange (ETDEWEB)

Hertzel, J.S.

1997-01-31

Los Alamos Technical Associates, Inc., is pleased to transmit the attached Conceptual Design Package for the Initial Single Shell Tank Retrieval System (ISSTRS), 90% Conceptual Design Review. The package includes the following: (1) ISSTRS Trade Studies: (a) Retrieval Facility Cooling Requirements; (b) Equipment Re-usability between Project W-320 and Tanks 241-C-103 and 241-C-1 05; (c) Sluice Line Options; and (d) Options for the Location of Tanks AX-103 and A-1 02 HVAC Equipment; (2) Drawings; (3) Risk Management Plan; (4) 0850 Interface Control Document; (5) Requirements Traceability Report; and (6) Project Design Specification.

The Uniqueness of Milton Friedman

OpenAIRE

J. Daniel Hammond

2013-01-01

That there is no Milton Friedman today is not a mystery; the mystery is how Milton Friedman could have been. The facts of Friedman’s biography make him unique among twentieth-century public figures. He had extensive knowledge and expertise in mathematics and statistics. Yet he became a critic of ‘formal’ theory, exemplified by mathematical economics, that failed to engage with real-world facts and data, and of econometric modeling that presumed more knowledge of economic structure than Friedm...

Move the Neighbourhood: Study design of a community-based participatory public open space intervention in a Danish deprived neighbourhood to promote active living

Directory of Open Access Journals (Sweden)

Charlotte Skau Pawlowski

2017-05-01

Full Text Available Abstract Background A limited amount of research has examined the effect of changing public open spaces on active living. This paper will present the study protocol of a community-based intervention study co-designed in an interdisciplinary collaboration with community members to develop urban installations highly tailored to promote active living among children (10–13-years-old and seniors (>60-years-old in a deprived neighbourhood in Copenhagen. Methods The study builds on a quasi-experimental study design with two sub-studies: 1 a children study and 2 a senior study. The interventions will be developed, designed and implemented in collaboration with local children and seniors, respectively, using different co-design tools and methods. We will evaluate the effect of the interventions on children’s and senior’s use of the new-built urban installations using accelerometers in combination with GPS as well as systematic observation using the System for Observing Play and Recreation in Communities (SOPARC. A process evaluation with focus groups consisting of the various stakeholders in the two sub-studies will be used to gain knowledge of the intervention processes. Discussion The paper presents new approaches in the field of public open space interventions through interdisciplinary collaboration, participatory co-design approach and combination of measurements. Using both effect and process evaluations the study will provide unique insights in the role and importance of the interdisciplinary collaboration, participatory processes, and tailoring changes in public open space to local needs and wishes. These results can be used to guide urban renewal projects in deprived neighbourhoods in the future. Trial registration Retrospectively registered with study ID ISRCTN50036837 . Date of registration: 16 December 2016.

Move the Neighbourhood: Study design of a community-based participatory public open space intervention in a Danish deprived neighbourhood to promote active living.

Science.gov (United States)

Pawlowski, Charlotte Skau; Winge, Laura; Carroll, Sidse; Schmidt, Tanja; Wagner, Anne Margrethe; Nørtoft, Kamilla Pernille Johansen; Lamm, Bettina; Kural, René; Schipperijn, Jasper; Troelsen, Jens

2017-05-19

A limited amount of research has examined the effect of changing public open spaces on active living. This paper will present the study protocol of a community-based intervention study co-designed in an interdisciplinary collaboration with community members to develop urban installations highly tailored to promote active living among children (10-13-years-old) and seniors (>60-years-old) in a deprived neighbourhood in Copenhagen. The study builds on a quasi-experimental study design with two sub-studies: 1) a children study and 2) a senior study. The interventions will be developed, designed and implemented in collaboration with local children and seniors, respectively, using different co-design tools and methods. We will evaluate the effect of the interventions on children's and senior's use of the new-built urban installations using accelerometers in combination with GPS as well as systematic observation using the System for Observing Play and Recreation in Communities (SOPARC). A process evaluation with focus groups consisting of the various stakeholders in the two sub-studies will be used to gain knowledge of the intervention processes. The paper presents new approaches in the field of public open space interventions through interdisciplinary collaboration, participatory co-design approach and combination of measurements. Using both effect and process evaluations the study will provide unique insights in the role and importance of the interdisciplinary collaboration, participatory processes, and tailoring changes in public open space to local needs and wishes. These results can be used to guide urban renewal projects in deprived neighbourhoods in the future. Retrospectively registered with study ID ISRCTN50036837 . Date of registration: 16 December 2016.

Designing the Internet of things

CERN Document Server

McEwen, Adrian

2013-01-01

Take your idea from concept to production with this unique guide Whether it's called physical computing, ubiquitous computing, or the Internet of Things, it's a hot topic in technology: how to channel your inner Steve Jobs and successfully combine hardware, embedded software, web services, electronics, and cool design to create cutting-edge devices that are fun, interactive, and practical. If you'd like to create the next must-have product, this unique book is the perfect place to start. Both a creative and practical primer, it explores the platforms you can use to develop hardware or softw

High Blood Pressure: Unique to Older Adults

Science.gov (United States)

... our e-newsletter! Aging & Health A to Z High Blood Pressure Hypertension Unique to Older Adults This section provides ... Pressure Targets are Different for Very Old Adults High blood pressure (also called hypertension) increases your chance of having ...

An Underlying Common Factor, Influenced by Genetics and Unique Environment, Explains the Covariation Between Major Depressive Disorder, Generalized Anxiety Disorder, and Burnout: A Swedish Twin Study.

Science.gov (United States)

Mather, Lisa; Blom, Victoria; Bergström, Gunnar; Svedberg, Pia

2016-12-01

Depression and anxiety are highly comorbid due to shared genetic risk factors, but less is known about whether burnout shares these risk factors. We aimed to examine whether the covariation between major depressive disorder (MDD), generalized anxiety disorder (GAD), and burnout is explained by common genetic and/or environmental factors. This cross-sectional study included 25,378 Swedish twins responding to a survey in 2005-2006. Structural equation models were used to analyze whether the trait variances and covariances were due to additive genetics, non-additive genetics, shared environment, and unique environment. Univariate analyses tested sex limitation models and multivariate analysis tested Cholesky, independent pathway, and common pathway models. The phenotypic correlations were 0.71 (0.69-0.74) between MDD and GAD, 0.58 (0.56-0.60) between MDD and burnout, and 0.53 (0.50-0.56) between GAD and burnout. Heritabilities were 45% for MDD, 49% for GAD, and 38% for burnout; no statistically significant sex differences were found. A common pathway model was chosen as the final model. The common factor was influenced by genetics (58%) and unique environment (42%), and explained 77% of the variation in MDD, 69% in GAD, and 44% in burnout. GAD and burnout had additive genetic factors unique to the phenotypes (11% each), while MDD did not. Unique environment explained 23% of the variability in MDD, 20% in GAD, and 45% in burnout. In conclusion, the covariation was explained by an underlying common factor, largely influenced by genetics. Burnout was to a large degree influenced by unique environmental factors not shared with MDD and GAD.

Parametric design study of tandem mirror fusion reactors

International Nuclear Information System (INIS)

Carlson, G.A.

1977-01-01

The parametric design study of the tandem mirror reactor (TMR) is described. The results of this study illustrate the variation of reactor characteristics with changes in the independent design parameters, reveal the set of design parameters which minimizes the cost of the reactor, and show the sensitivity of the optimized design to physics and technological uncertainties. The total direct capital cost of an optimized 1000 MWe TMR is estimated to be $1300/kWe. The direct capital cost of a 2000 MWe plant is less than $1000/kWe

Design study on sodium-cooled large-scale reactor

International Nuclear Information System (INIS)

Shimakawa, Yoshio; Nibe, Nobuaki; Hori, Toru

2002-05-01

In Phase 1 of the 'Feasibility Study on Commercialized Fast Reactor Cycle Systems (F/S)', an advanced loop type reactor has been selected as a promising concept of sodium-cooled large-scale reactor, which has a possibility to fulfill the design requirements of the F/S. In Phase 2 of the F/S, it is planed to precede a preliminary conceptual design of a sodium-cooled large-scale reactor based on the design of the advanced loop type reactor. Through the design study, it is intended to construct such a plant concept that can show its attraction and competitiveness as a commercialized reactor. This report summarizes the results of the design study on the sodium-cooled large-scale reactor performed in JFY2001, which is the first year of Phase 2. In the JFY2001 design study, a plant concept has been constructed based on the design of the advanced loop type reactor, and fundamental specifications of main systems and components have been set. Furthermore, critical subjects related to safety, structural integrity, thermal hydraulics, operability, maintainability and economy have been examined and evaluated. As a result of this study, the plant concept of the sodium-cooled large-scale reactor has been constructed, which has a prospect to satisfy the economic goal (construction cost: less than 200,000yens/kWe, etc.) and has a prospect to solve the critical subjects. From now on, reflecting the results of elemental experiments, the preliminary conceptual design of this plant will be preceded toward the selection for narrowing down candidate concepts at the end of Phase 2. (author)

Unitary evolution and uniqueness of the Fock quantization in flat cosmologies

International Nuclear Information System (INIS)

Marugán, G A Mena; Błas, D Martín-de; Gomar, L Castelló

2013-01-01

We study the Fock quantization of scalar fields with a time dependent mass in cosmological scenarios with flat compact spatial sections. This framework describes physically interesting situations like, e.g., cosmological perturbations in flat Friedmann-Robertson-Walker spacetimes, generally including a suitable scaling of them by a background function. We prove that the requirements of vacuum invariance under the spatial isometries and of a unitary quantum dynamics select (a) a unique canonical pair of field variables among all those related by time dependent canonical transformations which scale the field configurations, and (b) a unique Fock representation for the canonical commutation relations of this pair of variables. The proof is generalizable to any compact spatial topology in three or less dimensions, though we focus on the case of the three-torus owing to the especially relevant implications.

Unique Protein Signature of Circulating Microparticles in Systemic Lupus Erythematosus

DEFF Research Database (Denmark)

Østergaard, Ole; Nielsen, Christoffer; Iversen, Line V

2013-01-01

To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases.......To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases....

About face the essentials of interaction design

CERN Document Server

Cooper, Alan; Cronin, David; Noessel, Christopher

2014-01-01

The essential interaction design guide, fully revised and updated for the mobile ageAbout Face: The Essentials of Interaction Design, Fourth Edition is the latest update to the book that shaped and evolved the landscape of interaction design. This comprehensive guide takes the worldwide shift to smartphones and tablets into account.  New information includes discussions on mobile apps, touch interfaces, screen size considerations, and more. The new full-color interior and unique layout better illustrate modern design concepts.  The interaction design profession is blooming with the success o

Flight Path Recovery System (FPRS) design study

International Nuclear Information System (INIS)

1978-09-01

The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented

Flight Path Recovery System (FPRS) design study

Energy Technology Data Exchange (ETDEWEB)

1978-09-01

The study contained herein presents a design for a Flight Path Recovery System (FPPS) for use in the NURE Program which will be more accurate than systems presently used, provide position location data in digital form suitable for automatic data processing, and provide for flight path recovery in a more economic and operationally suitable manner. The design is based upon the use of presently available hardware and technoloy, and presents little, it any, development risk. In addition, a Flight Test Plan designed to test the FPRS design concept is presented.

A Framework for Systemic Design

Directory of Open Access Journals (Sweden)

Alex Ryan

2014-12-01

Full Text Available As designers move upstream from traditional product and service design to engage with challenges characterised by complexity, uniqueness, value conflict, and ambiguity over objectives, they have increasingly integrated systems approaches into their practice. This synthesis of systems thinking with design thinking is forming a distinct new field of systemic design. This paper presents a framework for systemic design as a mindset, methodology, and set of methods that together enable teams to learn, innovate, and adapt to a complex and dynamic environment. We suggest that a systemic design mindset is inquiring, open, integrative, collaborative, and centred. We propose a systemic design methodology composed of six main activities: framing, formulating, generating, reflecting, inquiring, and facilitating. We view systemic design methods as a flexible and open-ended set of procedures for facilitating group collaboration that are both systemic and designerly.  

Empirical studies of design software: Implications for software engineering environments

Science.gov (United States)

Krasner, Herb

1988-01-01

The empirical studies team of MCC's Design Process Group conducted three studies in 1986-87 in order to gather data on professionals designing software systems in a range of situations. The first study (the Lift Experiment) used thinking aloud protocols in a controlled laboratory setting to study the cognitive processes of individual designers. The second study (the Object Server Project) involved the observation, videotaping, and data collection of a design team of a medium-sized development project over several months in order to study team dynamics. The third study (the Field Study) involved interviews with the personnel from 19 large development projects in the MCC shareholders in order to study how the process of design is affected by organizationl and project behavior. The focus of this report will be on key observations of design process (at several levels) and their implications for the design of environments.

Transcriptome profile and unique genetic evolution of positively selected genes in yak lungs.

Science.gov (United States)

Lan, DaoLiang; Xiong, XianRong; Ji, WenHui; Li, Jian; Mipam, Tserang-Donko; Ai, Yi; Chai, ZhiXin

2018-04-01

The yak (Bos grunniens), which is a unique bovine breed that is distributed mainly in the Qinghai-Tibetan Plateau, is considered a good model for studying plateau adaptability in mammals. The lungs are important functional organs that enable animals to adapt to their external environment. However, the genetic mechanism underlying the adaptability of yak lungs to harsh plateau environments remains unknown. To explore the unique evolutionary process and genetic mechanism of yak adaptation to plateau environments, we performed transcriptome sequencing of yak and cattle (Bos taurus) lungs using RNA-Seq technology and a subsequent comparison analysis to identify the positively selected genes in the yak. After deep sequencing, a normal transcriptome profile of yak lung that containing a total of 16,815 expressed genes was obtained, and the characteristics of yak lungs transcriptome was described by functional analysis. Furthermore, Ka/Ks comparison statistics result showed that 39 strong positively selected genes are identified from yak lungs. Further GO and KEGG analysis was conducted for the functional annotation of these genes. The results of this study provide valuable data for further explorations of the unique evolutionary process of high-altitude hypoxia adaptation in yaks in the Tibetan Plateau and the genetic mechanism at the molecular level.

Computer Aided Methodology for Simultaneous Synthesis, Design & Analysis of Chemical Products-Processes

DEFF Research Database (Denmark)

d'Anterroches, Loïc; Gani, Rafiqul

2006-01-01

A new combined methodology for computer aided molecular design and process flowsheet design is presented. The methodology is based on the group contribution approach for prediction of molecular properties and design of molecules. Using the same principles, process groups have been developed...... a wide range of problems. In this paper, only the computer aided flowsheet design related features are presented....... together with their corresponding flowsheet property models. To represent the process flowsheets in the same way as molecules, a unique but simple notation system has been developed. The methodology has been converted into a prototype software, which has been tested with several case studies covering...

Evolution of Wholesale Electricity Market Design with Increasing Levels of Renewable Generation

Energy Technology Data Exchange (ETDEWEB)

Ela, E.; Milligan, M.; Bloom, A.; Botterud, A.; Townsend, A.; Levin, T.

2014-09-01

Variable generation such as wind and photovoltaic solar power has increased substantially in recent years. Variable generation has unique characteristics compared to the traditional technologies that supply energy in the wholesale electricity markets. These characteristics create unique challenges in planning and operating the power system, and they can also influence the performance and outcomes from electricity markets. This report focuses on two particular issues related to market design: revenue sufficiency for long-term reliability and incentivizing flexibility in short-term operations. The report provides an overview of current design and some designs that have been proposed by industry or researchers.

Design vs. Content: A Study of Adolescent Girls' Website Design Preferences

Science.gov (United States)

Agosto, Denise E.

2004-01-01

This study considered the utility of gender schema theory in examining girls' website design preferences. It built on a previous study which identified eight website evaluation criteria related to biological sex: collaboration, social connectivity, flexibility, motility, contextuality, personal identification, inclusion, and graphic/multimedia…

Design and fabrication of a unique electromechanical machine for long-term fatigue testing

International Nuclear Information System (INIS)

Boling, K.W.

1984-12-01

An electromechanical machine has been designed and fabricated for performing long-term fatigue tests under conditions that simulate those in modern plants. The machine is now commercially available. Its advantages over current electrohydraulic machines are lower initial cost, minimum maintenance requirements, and greater reliability especially when performing long tests. The machine operates in closed-loop fashion by utilizing continuous feedback signals from the specimen extensometer or load cell, it is programmable for testing in strain or load control. The maximum ram rate is 0.056 mm/s (0.134 in./min), maximum ram travel is 102 mm (4 in.) and load capacity is +-44 (+-10 kips). Induction heating controls speciment temperatures to 1000 0 C

Adapting the Unique Minds Program: Exploring the Feasibility of a Multiple Family Intervention for Children with Learning Disabilities in the Context of Spain.

Science.gov (United States)

López-Larrosa, Silvia; González-Seijas, Rosa M; Carpenter, John S W

2017-06-01

The Unique Minds Program (Stern, Unique Minds Program, 1999) addresses the socio-emotional needs of children with learning disabilities (LD) and their families. Children and their parents work together in a multiple family group to learn more about LD and themselves as people with the capacity to solve problems in a collaborative way, including problems in family school relationships. This article reports the cultural adaptation of the program for use in Spain and findings from a feasibility study involving three multiple family groups and a total of 15 children and 15 mothers, using a pre-post design. This Spanish adaptation of the program is called "Mentes Únicas". Standardized outcome measures indicated an overall statistically significant decrease in children's self-rated maladjustment and relationship difficulties by the end of the program. Improvements were endorsed by most mothers, although they were not always recognized by the children's teachers. The program had a high level of acceptability: Mothers and children felt safe, understood, and helped throughout the sessions. The efficacy of the adapted intervention for the context of Spain remains to be tested in a more rigorous study. © 2016 Family Process Institute.

The Urban Environment and Childhood Asthma (URECA birth cohort study: design, methods, and study population

Directory of Open Access Journals (Sweden)

Sandel Megan T

2009-05-01

Full Text Available Abstract Background The incidence and morbidity of wheezing illnesses and childhood asthma is especially high in poor urban areas. This paper describes the study design, methods, and population of the Urban Environment and Childhood Asthma (URECA study, which was established to investigate the immunologic causes of asthma among inner-city children. Methods and Results URECA is an observational prospective study that enrolled pregnant women in central urban areas of Baltimore, Boston, New York City, and St. Louis and is following their offspring from birth through age 7 years. The birth cohort consists of 560 inner-city children who have at least one parent with an allergic disease or asthma, and all families live in areas in which at least 20% of the population has incomes below the poverty line. In addition, 49 inner-city children with no parental history of allergies or asthma were enrolled. The primary hypothesis is that specific urban exposures in early life promote a unique pattern of immune development (impaired antiviral and increased Th2 responses that increases the risk of recurrent wheezing and allergic sensitization in early childhood, and of asthma by age 7 years. To track immune development, cytokine responses of blood mononuclear cells stimulated ex vivo are measured at birth and then annually. Environmental assessments include allergen and endotoxin levels in house dust, pre- and postnatal maternal stress, and indoor air nicotine and nitrogen dioxide. Nasal mucous samples are collected from the children during respiratory illnesses and analyzed for respiratory viruses. The complex interactions between environmental exposures and immune development will be assessed with respect to recurrent wheeze at age 3 years and asthma at age 7 years. Conclusion The overall goal of the URECA study is to develop a better understanding of how specific urban exposures affect immune development to promote wheezing illnesses and asthma.

Design study of laser fusion rocket

International Nuclear Information System (INIS)

Nakashima, Hideki; Shoyama, Hidetoshi; Kanda, Yukinori

1991-01-01

A design study was made on a rocket powered by laser fusion. Dependence of its flight performance on target gain, driver repetition rate and fuel composition was analyzed to obtain optimal design parameters of the laser fusion rocket. The results indicate that the laser fusion rocket fueled with DT or D 3 He has the potential advantages over other propulsion systems such as fission rocket for interplanetary travel. (author)

Core design and fuel management studies

International Nuclear Information System (INIS)

Min, Byung Joo; Chan, P.

1997-06-01

The design target for the CANDU 9 requires a 20% increase in electrical power output from an existing 480-channel CANDU core. Assuming a net electrical output of 861 MW(e) for a natural uranium fuelled Bruce-B/Darlington reactor in a warm water site, the net electrical output of the reference CANDU 9 reactor would be 1033 MW(e). This report documents the result of the physics studies for the design of the CANDU 9 480/SEU core. The results of the core design and fuel management studies of the CANDU 9 480/SEU reactor indicated that up to 1033 MW(e) output can be achieved in a 480-channel CANDU core by using SEU core can easily be maintained indefinitely using an automated refuelling program. Fuel performance evaluation based on the data of the 500 FPDs refuelling simulation concluded that SEU fuel failure is not expected. (author). 2 tabs., 38 figs., 5 refs

Transitioning from Marketing-Oriented Design to User-Oriented Design: A Case Study

Science.gov (United States)

Laster, Shari; Stitz, Tammy; Bove, Frank J.; Wise, Casey

2011-01-01

The transition to a new architecture and design for an academic library Web site does not always proceed smoothly. In this case study, a library at a large research university hired an outside Web development contractor to create a new architecture and design for the university's Web site using dotCMS, an open-source content management system. The…

Global Existence and Uniqueness of Weak and Regular Solutions of Shallow Shells with Thermal Effects

Energy Technology Data Exchange (ETDEWEB)

Menzala, G. Perla, E-mail: perla@lncc.br [National Laboratory of Scientific Computation, (LNCC/MCTI) (Brazil); Cezaro, F. Travessini De, E-mail: fabianacezaro@furg.br [Federal University of Rio Grande (FURG/IMEF), Institute of Mathematics, Statistics and Physics (Brazil)

2016-10-15

We study a dynamical thin shallow shell whose elastic deformations are described by a nonlinear system of Marguerre–Vlasov’s type under the presence of thermal effects. Our main result is the proof of a global existence and uniqueness of a weak solution in the case of clamped boundary conditions. Standard techniques for uniqueness do not work directly in this case. We overcame this difficulty using recent work due to Lasiecka (Appl Anal 4:1376–1422, 1998).

Couple-level Minority Stress: An Examination of Same-sex Couples' Unique Experiences.

Science.gov (United States)

Frost, David M; LeBlanc, Allen J; de Vries, Brian; Alston-Stepnitz, Eli; Stephenson, Rob; Woodyatt, Cory

2017-12-01

Social stress resulting from stigma, prejudice, and discrimination-"minority stress"-negatively impacts sexual minority individuals' health and relational well-being. The present study examined how being in a same-sex couple can result in exposure to unique minority stressors not accounted for at the individual level. Relationship timeline interviews were conducted with 120 same-sex couples equally distributed across two study sites (Atlanta and San Francisco), gender (male and female), and relationship duration (at least six months but less than three years, at least three years but less than seven years, and seven or more years). Directed content analyses identified 17 unique couple-level minority stressors experienced within nine distinct social contexts. Analyses also revealed experiences of dyadic minority stress processes (stress discrepancies and stress contagion). These findings can be useful in future efforts to better understand and address the cumulative impact of minority stress on relational well-being and individual health.

Finite-Element Model-Based Design Synthesis of Axial Flux PMBLDC Motors

DEFF Research Database (Denmark)

Fasil, Muhammed; Mijatovic, Nenad; Jensen, Bogi Bech

2016-01-01

of a unique solution. The designer can later select a design, based on comparing parameters of the designs, which are critical to the application that the motor will be used. The presented approach makes it easier to define constraints for a design synthesis problem. A detailed description of the setting up...

Study of Wind Effects on Unique Buildings

Science.gov (United States)

Olenkov, V.; Puzyrev, P.

2017-11-01

The article deals with a numerical simulation of wind effects on the building of the Church of the Intercession of the Holy Virgin in the village Bulzi of the Chelyabinsk region. We presented a calculation algorithm and obtained pressure fields, velocity fields and the fields of kinetic energy of a wind stream, as well as streamlines. Computational fluid dynamic (CFD) evolved three decades ago at the interfaces of calculus mathematics and theoretical hydromechanics and has become a separate branch of science the subject of which is a numerical simulation of different fluid and gas flows as well as the solution of arising problems with the help of methods that involve computer systems. This scientific field which is of a great practical value is intensively developing. The increase in CFD-calculations is caused by the improvement of computer technologies, creation of multipurpose easy-to-use CFD-packagers that are available to a wide group of researchers and cope with various tasks. Such programs are not only competitive in comparison with physical experiments but sometimes they provide the only opportunity to answer the research questions. The following advantages of computer simulation can be pointed out: a) Reduction in time spent on design and development of a model in comparison with a real experiment (variation of boundary conditions). b) Numerical experiment allows for the simulation of conditions that are not reproducible with environmental tests (use of ideal gas as environment). c) Use of computational gas dynamics methods provides a researcher with a complete and ample information that is necessary to fully describe different processes of the experiment. d) Economic efficiency of computer calculations is more attractive than an experiment. e) Possibility to modify a computational model which ensures efficient timing (change of the sizes of wall layer cells in accordance with the chosen turbulence model).

Advanced customization in architectural design and construction

CERN Document Server

Naboni, Roberto

2015-01-01

This book presents the state of the art in advanced customization within the sector of architectural design and construction, explaining important new technologies that are boosting design, product and process innovation and identifying the challenges to be confronted as we move toward a mass customization construction industry. Advanced machinery and software integration are discussed, as well as an overview of the manufacturing techniques offered through digital methods that are acquiring particular significance within the field of digital architecture. CNC machining, Robotic Fabrication, and Additive Manufacturing processes are all clearly explained, highlighting their ability to produce personalized architectural forms and unique construction components. Cutting-edge case studies in digitally fabricated architectural realizations are described and, looking towards the future, a new model of 100% customized architecture for design and construction is presented. The book is an excellent guide to the profoun...

Technology transfer and design conversion of a dry spent fuel storage system in Ukraine

International Nuclear Information System (INIS)

Peacock, R.C.; Marcelli, D.G.

1998-01-01

A number of unique issues surfaced in the technology transfer and design conversion of a US dry spent fuel storage technology in Ukraine. Unique challenges were encountered in the areas of nuclear design conversion, technical codes and standards, material selection and qualification, fabrication, construction and testing, quality assurance, documentation, and translation and verification processes. Technology transfer and design conversion were undertaken for both concrete and steel components for the project. The overall effort presented significant technical and cultural challenges to both the US and Ukrainian side, but technical exchange and design improvements to achieve a common goal have been reached. (author)

Temporal information partitioning: Characterizing synergy, uniqueness, and redundancy in interacting environmental variables

Science.gov (United States)

Goodwell, Allison E.; Kumar, Praveen

2017-07-01

Information theoretic measures can be used to identify nonlinear interactions between source and target variables through reductions in uncertainty. In information partitioning, multivariate mutual information is decomposed into synergistic, unique, and redundant components. Synergy is information shared only when sources influence a target together, uniqueness is information only provided by one source, and redundancy is overlapping shared information from multiple sources. While this partitioning has been applied to provide insights into complex dependencies, several proposed partitioning methods overestimate redundant information and omit a component of unique information because they do not account for source dependencies. Additionally, information partitioning has only been applied to time-series data in a limited context, using basic pdf estimation techniques or a Gaussian assumption. We develop a Rescaled Redundancy measure (Rs) to solve the source dependency issue, and present Gaussian, autoregressive, and chaotic test cases to demonstrate its advantages over existing techniques in the presence of noise, various source correlations, and different types of interactions. This study constitutes the first rigorous application of information partitioning to environmental time-series data, and addresses how noise, pdf estimation technique, or source dependencies can influence detected measures. We illustrate how our techniques can unravel the complex nature of forcing and feedback within an ecohydrologic system with an application to 1 min environmental signals of air temperature, relative humidity, and windspeed. The methods presented here are applicable to the study of a broad range of complex systems composed of interacting variables.

Concentration and mindfulness meditations: unique forms of consciousness?

Science.gov (United States)

Dunn, B R; Hartigan, J A; Mikulas, W L

1999-09-01

Electroencephalographic (EEG) recordings from 19 scalp recording sites were used to differentiate among two posited unique forms of mediation, concentration and mindfulness, and a normal relaxation control condition. Analyzes of all traditional frequency bandwidth data (i.e., delta 1-3 Hz; theta, 4-7 Hz; alpha, 8-12 Hz; beta 1, 13-25 Hz; beta 2, 26-32 Hz) showed strong mean amplitude frequency differences between the two meditation conditions and relaxation over numerous cortical sites. Furthermore, significant differences were obtained between concentration and mindfulness states at all bandwidths. Taken together, our results suggest that concentration and mindfulness "meditations" may be unique forms of consciousness and are not merely degrees of a state of relaxation.

Solitary intraosseous neurofibroma: Report of a unique case

Directory of Open Access Journals (Sweden)

Sagar Satish Jangam

2014-01-01

Full Text Available Neural tumors located centrally in jaw bones are relatively rare compared with soft tissue neurofibromas. Less than 50 cases have been reported in the literature with a predilection for mandible. This article aims to elucidate a unique case of intraosseous neurofibroma of mandible in a 62-year-old edentulous female patient associated with facial asymmetry due to the swelling extending from the right body of mandible to left body of mandible. The uniqueness of this case is related to the age and extensiveness of this lesion. A review of clinical, radiographic, histological, and immunohistochemical features, and the surgical management pertaining to this case are discussed along with a review of the literature.

On some properties of bone functional adaptation phenomenon useful in mechanical design.

Science.gov (United States)

Nowak, Michał

2010-01-01

The paper discusses some unique properties of trabecular bone functional adaptation phenomenon, useful in mechanical design. On the basis of the biological process observations and the principle of constant strain energy density on the surface of the structure, the generic structural optimisation system has been developed. Such approach allows fulfilling mechanical theorem for the stiffest design, comprising the optimisations of size, shape and topology, using the concepts known from biomechanical studies. Also the biomimetic solution of multiple load problems is presented.

Design Evolution Study - Aging Options

International Nuclear Information System (INIS)

McDaniel, P.

2002-01-01

The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new

Safety aspects of designs for future light water reactors (evolutionary reactors)

International Nuclear Information System (INIS)

1993-07-01

The main purpose of this document is to describe the major innovations of proposed designs of future light water reactors, to describe specific safety characteristics and safety analysis methodologies, and to give a general overview of the most important safety aspects related to future reactors. The reactors considered in this report are limited to those intended for fixed station electrical power production, excluding most revolutionary concepts. More in depth discussion is devoted to those designs that are in a more advanced state of completion and have been more extensively described and analysed in the open literature. Other designs will be briefly described, as evidence of the large spectrum of new proposals. Some designs are similar; others implement unique features and require specific discussion (not all aspects of designs with unique features are fully discussed in this document). 131 refs, 22 figs

INEL design studies in support of the Westinghouse EPRI small plant study

International Nuclear Information System (INIS)

Burtt, J.D.; Kullberg, C.M.

1986-03-01

In support of the design effort of a Westinghouse EPRI small plant study, several analyses were performed at the Idaho National Engineering Laboratory. An analysis was performed to study fuel behavior under conditions of a limiting flow coastdown transient. Depressurization capabilities for the reactor coolant system were studied. The post-accident heat removal for the current containment design was studied. The results of all three studies are reported. 31 figs

Unique properties of Drosophila spermatocyte primary cilia

Directory of Open Access Journals (Sweden)

Maria Giovanna Riparbelli

2013-09-01

The primary cilium is an essential organelle required for animal development and adult homeostasis that is found on most animal cells. The primary cilium contains a microtubule-based axoneme cytoskeleton that typically grows from the mother centriole in G0/G1 phase of the cell cycle as a membrane-bound compartment that protrudes from the cell surface. A unique system of bidirectional transport, intraflagellar transport (IFT, maintains the structure and function of cilia. While the axoneme is dynamic, growing and shrinking at its tip, at the same time it is very stable to the effects of microtubule-targeting drugs. The primary cilia found on Drosophila spermatocytes diverge from the general rules of primary cilium biology in several respects. Among these unique attributes, spermatocyte cilia assemble from all four centrioles in an IFT-independent manner in G2 phase, and persist continuously through two cell divisions. Here, we show that Drosophila spermatocyte primary cilia are extremely sensitive to microtubule-targeting drugs, unlike their mammalian counterparts. Spermatocyte cilia and their axonemes fail to assemble or be maintained upon nocodazole treatment, while centriole replication appears unperturbed. On the other hand, paclitaxel (Taxol, a microtubule-stabilizing drug, disrupted transition zone assembly and anchoring to the plasma membrane while causing spermatocyte primary cilia to grow extensively long during the assembly/elongation phase, but did not overtly affect the centrioles. However, once assembled to their mature length, spermatocyte cilia appeared unaffected by Taxol. The effects of these drugs on axoneme dynamics further demonstrate that spermatocyte primary cilia are endowed with unique assembly properties.

A Unique (3+2) Annulation Reaction between Meldrum's Acid and Nitrones: Mechanistic Insight by ESI-IMS-MS and DFT Studies.

Science.gov (United States)

Lespes, Nicolas; Pair, Etienne; Maganga, Clisy; Bretier, Marie; Tognetti, Vincent; Joubert, Laurent; Levacher, Vincent; Hubert-Roux, Marie; Afonso, Carlos; Loutelier-Bourhis, Corinne; Brière, Jean-François

2018-03-15

The fragile intermediates of the domino process leading to an isoxazolidin-5-one, triggered by unique reactivity between Meldrum's acid and an N-benzyl nitrone in the presence of a Brønsted base, were determined thanks to the softness and accuracy of electrospray ionization mass spectrometry coupled to ion mobility spectrometry (ESI-IMS-MS). The combined DFT study shed light on the overall organocatalytic sequence that starts with a stepwise (3+2) annulation reaction that is followed by a decarboxylative protonation sequence encompassing a stereoselective pathway issue. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Individual- and Organization-level Work-to-Family Spillover are Uniquely Associated with Hotel Managers' Work Exhaustion and Satisfaction

Directory of Open Access Journals (Sweden)

Soomi Lee

2016-08-01

Full Text Available Purpose: Building on the Conservation of Resources theory, this paper examined the unique and interactive associations of negative and positive work-to-family spillover (NWFS and PWFS, respectively at the individual and organizational level with hotel managers’ wok exhaustion and satisfaction, beyond job demands and supervisors’ leadership style. Design/methodology/approach: Guided by the levels of analysis framework, we first tested the unique associations of NWFS and PWFS with emotional exhaustion and job satisfaction at the individual level (571 hotel managers, beyond job demands supervisors’ leadership style. Second, using multilevel modeling, we tested the climate effects of NWFS and PWFS on emotional exhaustion and job satisfaction aggregated at the organizational level (41 hotels. Third, we examined the role of the organizational climate of PWFS in the associations of individual-level NWFS with emotional exhaustion and job satisfaction. Findings: Beyond the effects of psychological job demands and supervisor’s transformational leadership, at the individual level, hotel managers who experienced higher NWFS than other managers reported more exhaustion and lower job satisfaction, whereas those with higher PWFS reported less exhaustion and higher satisfaction. At the organizational level, working in hotels where the average level of NWFS was higher than other hotels was associated with feeling more exhaustion of the individual members; working in hotels with higher PWFS was associated with feeling less exhaustion. The negative link between individual-level NWFS and job satisfaction was buffered when organization-level PWFS was higher, compared to when it was lower. Originality/value: This study moves beyond a focus on traditional job characteristics, toward considering individual and organizational experiences in the work-family interface as unique predictors of work exhaustion and satisfaction. Strengths of the study include

Unique Features of Halophilic Proteins.

Science.gov (United States)

Arakawa, Tsutomu; Yamaguchi, Rui; Tokunaga, Hiroko; Tokunaga, Masao

2017-01-01

Proteins from moderate and extreme halophiles have unique characteristics. They are highly acidic and hydrophilic, similar to intrinsically disordered proteins. These characteristics make the halophilic proteins soluble in water and fold reversibly. In addition to reversible folding, the rate of refolding of halophilic proteins from denatured structure is generally slow, often taking several days, for example, for extremely halophilic proteins. This slow folding rate makes the halophilic proteins a novel model system for folding mechanism analysis. High solubility and reversible folding also make the halophilic proteins excellent fusion partners for soluble expression of recombinant proteins.

Pipe drafting and design

CERN Document Server

Parisher, Roy A

2011-01-01

Pipe Drafting and Design, Third Edition provides step-by-step instructions to walk pipe designers, drafters, and students through the creation of piping arrangement and isometric drawings. It includes instructions for the proper drawing of symbols for fittings, flanges, valves, and mechanical equipment. More than 350 illustrations and photographs provide examples and visual instructions. A unique feature is the systematic arrangement of drawings that begins with the layout of the structural foundations of a facility and continues through to the development of a 3-D model. Advanced chapters

Unique microstructure and excellent mechanical properties of ADI

Directory of Open Access Journals (Sweden)

Jincheng Liu

2006-11-01

Full Text Available Amongst the cast iron family, ADI has a unique microstructure and an excellent, optimised combination of mechanical properties. The main microstructure of ADI is ausferrite, which is a mixture ofextremely fine acicular ferrite and stable, high carbon austenite. There are two types of austenite in ADI:(1 the coarser and more equiaxed blocks of austenite between non-parallel acicular structures, which exist mainly in the last solidified area, and (2 the thin films of ustenite between the individual ferriteplatelets in the acicular structure. It is this unique microstructure, which gives ADI its excellent static and dynamic properties, and good low temperature impact toughness. The effect of microstructure on the mechanical properties is explained in more detail by examining the microstructure at the atomic scale. Considering the nanometer grain sizes, the unique microstructure, the excellent mechanical properties,good castability, (which enables near net shape components to be produced economically and in large volumes, and the fact that it can be 100% recycled, it is not overemphasized to call ADI a high-tech,nanometer and “green” material. ADI still has the potential to be further improved and its production and the number of applications for ADI will continue to grow, driven by the resultant cost savings over alternative materials.

Automated simulation and study of spatial-structural design processes

NARCIS (Netherlands)

Davila Delgado, J.M.; Hofmeyer, H.; Stouffs, R.; Sariyildiz, S.

2013-01-01

A so-called "Design Process Investigation toolbox" (DPI toolbox), has been developed. It is a set of computational tools that simulate spatial-structural design processes. Its objectives are to study spatial-structural design processes and to support the involved actors. Two case-studies are

Vegetation study in support of the design and optimization of vegetative soil covers, Sandia National Laboratories, Albuquerque, New Mexico.

Energy Technology Data Exchange (ETDEWEB)

Peace, Gerald (Jerry) L.; Goering, Timothy James (GRAM inc., Albuquerque, NM); Knight, Paul J. (Marron and Associates, Albuquerque, NM); Ashton, Thomas S. (Marron and Associates, Albuquerque, NM)

2004-11-01

A vegetation study was conducted in Technical Area 3 at Sandia National Laboratories, Albuquerque, New Mexico in 2003 to assist in the design and optimization of vegetative soil covers for hazardous, radioactive, and mixed waste landfills at Sandia National Laboratories/New Mexico and Kirtland Air Force Base. The objective of the study was to obtain site-specific, vegetative input parameters for the one-dimensional code UNSAT-H and to identify suitable, diverse native plant species for use on vegetative soil covers that will persist indefinitely as a climax ecological community with little or no maintenance. The identification and selection of appropriate native plant species is critical to the proper design and long-term performance of vegetative soil covers. Major emphasis was placed on the acquisition of representative, site-specific vegetation data. Vegetative input parameters measured in the field during this study include root depth, root length density, and percent bare area. Site-specific leaf area index was not obtained in the area because there was no suitable platform to measure leaf area during the 2003 growing season due to severe drought that has persisted in New Mexico since 1999. Regional LAI data was obtained from two unique desert biomes in New Mexico, Sevilletta Wildlife Refuge and Jornada Research Station.

Application of next-generation sequencing technology to study genetic diversity and identify unique SNP markers in bread wheat from Kazakhstan.

Science.gov (United States)

Shavrukov, Yuri; Suchecki, Radoslaw; Eliby, Serik; Abugalieva, Aigul; Kenebayev, Serik; Langridge, Peter

2014-09-28

New SNP marker platforms offer the opportunity to investigate the relationships between wheat cultivars from different regions and assess the mechanism and processes that have led to adaptation to particular production environments. Wheat breeding has a long history in Kazakhstan and the aim of this study was to explore the relationship between key varieties from Kazakhstan and germplasm from breeding programs for other regions. The study revealed 5,898 polymorphic markers amongst ten cultivars, of which 2,730 were mapped in the consensus genetic map. Mapped SNP markers were distributed almost equally across the A and B genomes, with between 279 and 484 markers assigned to each chromosome. Marker coverage was approximately 10-fold lower in the D genome. There were 863 SNP markers identified as unique to specific cultivars, and clusters of these markers (regions containing more than three closely mapped unique SNPs) showed specific patterns on the consensus genetic map for each cultivar. Significant intra-varietal genetic polymorphism was identified in three cultivars (Tzelinnaya 3C, Kazakhstanskaya rannespelaya and Kazakhstanskaya 15). Phylogenetic analysis based on inter-varietal polymorphism showed that the very old cultivar Erythrospermum 841 was the most genetically distinct from the other nine cultivars from Kazakhstan, falling in a clade together with the American cultivar Sonora and genotypes from Central and South Asia. The modern cultivar Kazakhstanskaya 19 also fell into a separate clade, together with the American cultivar Thatcher. The remaining eight cultivars shared a single sub-clade but were categorised into four clusters. The accumulated data for SNP marker polymorphisms amongst bread wheat genotypes from Kazakhstan may be used for studying genetic diversity in bread wheat, with potential application for marker-assisted selection and the preparation of a set of genotype-specific markers.

Social Capital and Institutions in Rural Kenya: Is Machakos Unique?

OpenAIRE

Nyangena, Wilfred; Sterner, Thomas

2008-01-01

In Eastern Africa, the experience of Machakos has been heavily debated between Malthusians and the more optimistic Boserupians. Machakos was the epitome of overpopulation and resource degradation in the 1950s, but has since thrived. The Boserupians view Machakos as an illustration of how population growth can solve rather than exacerbate the vicious cycle of poverty and resource degradation. The question arises whether Machakos is unique. This study investigates the role of social capital in ...

Distribution Network Design--literature study based

OpenAIRE

LI, ANG

2012-01-01

The focus of this research is companies' outbound distribution network design in supply chain management. Within the present competitive market, it is a fundamental importance for companies to achieve high level business performance with an effective supply chain. Outbound distribution network design as an important part in supply chain management, to a large extent decides whether companies can fulfill customers' requirement or not. Therefore, such a study is important for manufacturers and ...

Web design with HTML and CSS

CERN Document Server

Osborn, Jeremy

2011-01-01

"An invaluable full-color training package for Web design Web design consists of using multiple software tools and codes-such as Dreamweaver, Flash, Silverlight, Illustrator, Photoshop, HTML, and CSS, among others-to craft a unique, robust, and interactive websites. This book teaches you how to effectively use all the major tools involved in web design to create a site that is both attractive and functional. You'll go beyond the basics to learn best practices of good web design so you can go from the drawing board to a successful site. Combining full-color, step-by-step instructions with lesso

LOFT fuel design and operating experience

International Nuclear Information System (INIS)

Russell, M.L.

1979-01-01

The objective of the LOFT fuel design and fabrication effort was to provide a pressurized water reactor core that has (1) materials and geometric features to ensure that heat transfer, hydraulic, mechanical, chemical, metallurgical and nuclear behaviors are typical of large pressurized water reactors (PWR) during the loss-of-coolant accident (LOCA) sequence and (2) test instrumentation for measurement of core conditions. The LOFT core is unique because it is designed for exposure to several LOCAs without loss of function. This paper summarizes the design effort and extent to which the design objectives have been achieved

Designing Search UX Strategies for eCommerce Success

CERN Document Server

Nudelman, Greg

2011-01-01

Best practices, practical advice, and design ideas for successful ecommerce search A glaring gap has existed in the market for a resource that offers a comprehensive, actionable design patterns and design strategies for ecommerce search-but no longer. With this invaluable book, user experience designer and user researcher Greg Nudelman shares his years of experience working on popular ecommerce sites as he tackles even the most difficult ecommerce search design problems. Nudelman helps you create highly effective and intuitive ecommerce search design solutions and he takes a unique forward-thi

Body appreciation, interest in cosmetic enhancements, and need for uniqueness among U.S. college students.

Science.gov (United States)

Gillen, Meghan M; Dunaev, Jamie

2017-09-01

The aim of the current study was to examine associations between body appreciation and putative correlates that focus on self-enhancement and self-expression. Students (N=261; mean age=20.16years, SD=3.68; 60.9% female) from a non-residential college in the northeastern United States completed a questionnaire measuring body appreciation, interest in cosmetic enhancements, and need for uniqueness. Individuals with higher body appreciation and African Americans/Blacks reported significantly higher self-attributed need for uniqueness and significantly higher investment in a distinctive appearance. The association between body appreciation and interest in cosmetic enhancements (e.g., hair coloring) was not significant. Results suggest that body appreciation may be linked to a desire to express one's own unique qualities. Copyright © 2017 Elsevier Ltd. All rights reserved.

Space - A unique environment for process modeling R&D

Science.gov (United States)

Overfelt, Tony

1991-01-01

Process modeling, the application of advanced computational techniques to simulate real processes as they occur in regular use, e.g., welding, casting and semiconductor crystal growth, is discussed. Using the low-gravity environment of space will accelerate the technical validation of the procedures and enable extremely accurate determinations of the many necessary thermophysical properties. Attention is given to NASA's centers for the commercial development of space; joint ventures of universities, industries, and goverment agencies to study the unique attributes of space that offer potential for applied R&D and eventual commercial exploitation.

Rationality, irrationality and escalating behavior in lowest unique bid auctions.

Directory of Open Access Journals (Sweden)

Filippo Radicchi

Full Text Available Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions--lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of "bid space". The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets.

Rationality, Irrationality and Escalating Behavior in Lowest Unique Bid Auctions

Science.gov (United States)

Radicchi, Filippo; Baronchelli, Andrea; Amaral, Luís A. N.

2012-01-01

Information technology has revolutionized the traditional structure of markets. The removal of geographical and time constraints has fostered the growth of online auction markets, which now include millions of economic agents worldwide and annual transaction volumes in the billions of dollars. Here, we analyze bid histories of a little studied type of online auctions – lowest unique bid auctions. Similarly to what has been reported for foraging animals searching for scarce food, we find that agents adopt Lévy flight search strategies in their exploration of “bid space”. The Lévy regime, which is characterized by a power-law decaying probability distribution of step lengths, holds over nearly three orders of magnitude. We develop a quantitative model for lowest unique bid online auctions that reveals that agents use nearly optimal bidding strategies. However, agents participating in these auctions do not optimize their financial gain. Indeed, as long as there are many auction participants, a rational profit optimizing agent would choose not to participate in these auction markets. PMID:22279553

Interim report on the tandem mirror hybrid design study

International Nuclear Information System (INIS)

Moir, R.W.

1979-01-01

The initial phase of a 2-year design study of a tandem mirror fusion reactor is presented. The following chapters are included: (1) mechanical design of the plant; (2) plasma physics; (3) blanket design; (4) magnet design; (5) injector design; (6) direct convertor design; (7) balance of plant design; (8) fission burner reactor; (9) environment and safety; and (10) economic analysis

The electron-ion scattering experiment ELISe at the International Facility for Antiproton and Ion Research (FAIR)-A conceptual design study

Energy Technology Data Exchange (ETDEWEB)

Antonov, A.N.; Gaidarov, M.K. [INRNE-BAS Sofia (Bulgaria); Ivanov, M.V. [Grupo de Physica Nuclear, Complutense University of Madrid (Spain); Kadrev, D.N. [INRNE-BAS Sofia (Bulgaria); Aiche, M.; Barreau, G.; Czajkowski, S.; Jurado, B. [Centre d' Etudes Nucleaires Bordeaux-Gradingnan (CENBG) (France); Belier, G.; Chatillon, A.; Granier, T.; Taieb, J. [CEA Bruyeres-le-Chatel (France); Dore, D.; Letourneau, A.; Ridikas, D.; Dupont, E.; Berthoumieux, E.; Panebianco, S. [CEA Saclay (France); Farget, F.; Schmitt, C. [GANIL Caen (France)

2011-05-01

The electron-ion scattering experiment ELISe is part of the installations envisaged at the new experimental storage ring at the International Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It offers an unique opportunity to use electrons as probe in investigations of the structure of exotic nuclei. The conceptual design and the scientific challenges of ELISe are presented.

The electron-ion scattering experiment ELISe at the International Facility for Antiproton and Ion Research (FAIR)-A conceptual design study

International Nuclear Information System (INIS)

Antonov, A.N.; Gaidarov, M.K.; Ivanov, M.V.; Kadrev, D.N.; Aiche, M.; Barreau, G.; Czajkowski, S.; Jurado, B.; Belier, G.; Chatillon, A.; Granier, T.; Taieb, J.; Dore, D.; Letourneau, A.; Ridikas, D.; Dupont, E.; Berthoumieux, E.; Panebianco, S.; Farget, F.; Schmitt, C.

2011-01-01

The electron-ion scattering experiment ELISe is part of the installations envisaged at the new experimental storage ring at the International Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It offers an unique opportunity to use electrons as probe in investigations of the structure of exotic nuclei. The conceptual design and the scientific challenges of ELISe are presented.

Design study of 'HIBLIC-I' reactor cavity

International Nuclear Information System (INIS)

Fujiie, Y.

1984-01-01

A preliminary conceptual design of a reactor cavity for HIBLIC-1, a heavy ion fusion reactor system, was carried out. Design efforts have been concentrated mainly on the feasibility study of the physical scenario adopted and also on the system integration of the structures and components into a compact reactor cavity. The design features of the reactor are a compact reactor cavity, maximum coolant temperature up to 500 deg C, the protection of the sacrificial wall and cavity wall from radiation, the protection of the sacrificial wall from the pressure transient due to rapid heating, the selection of a ferritic steel HT-9 as the structural material and impurity control, and tritium breeding and recovery. The purpose of this paper is to describe the outline of the reactor cavity design of HIBLIC-1. The objectives of the preliminary conceptual design were to propose the idea and concept in order to constitute the physical scenario without contradiction and to find out the critical and fundamental problems to be studied in future. The cavity configuration and dynamics, tritium breeding and radiation damage, the behavior of a structural material in liquid lithium and tritium recovery are reported. (Kako, I.)

Innovative ways of studying the effect of migration on obesity and diabetes beyond the common designs: lessons from the RODAM study.

Science.gov (United States)

Agyemang, Charles; Beune, Erik; Meeks, Karlijn; Addo, Juliet; Aikins, Ama de-Graft; Bahendeka, Silver; Danquah, Ina; Mockenhaupt, Frank P; Schulze, Matthias B; Klipstein-Grobusch, Kerstin; Smeeth, Liam; Stronks, Karien

2017-03-01

Type 2 diabetes and obesity are major global public health problems, with migrant populations in high-income countries being particularly affected. Type 2 diabetes and obesity are also major threats in low- and middle-income countries, from which most migrant populations originate. Transitioning of societies and the resulting changes in lifestyles are thought to be major driving forces, but the key specific factors within this broad category still need to be determined. Migrant studies provide a unique opportunity to understand the potential underlying causes of these conditions, but current research is mainly geared toward analyzing the differences between migrants and the host populations in the countries of settlement. For better understanding, there is a need to extend migrant health research across national boundaries. This review discusses innovative ways of studying the effect of migration on type 2 diabetes and obesity beyond the common designs and the relevance of extending migrant health studies across national boundaries in the current era of increasing global migration. Specifically, we describe the burden and different methods for conducting migrant studies. We use the Research on Obesity and Diabetes among African Migrants (RODAM) study as a case study, discussing the methods, some results, and lessons learned, including challenges and an essential recipe for success that may guide future migrant health research. © 2016 New York Academy of Sciences.

Unique Fock quantization of scalar cosmological perturbations

Science.gov (United States)

Fernández-Méndez, Mikel; Mena Marugán, Guillermo A.; Olmedo, Javier; Velhinho, José M.

2012-05-01

We investigate the ambiguities in the Fock quantization of the scalar perturbations of a Friedmann-Lemaître-Robertson-Walker model with a massive scalar field as matter content. We consider the case of compact spatial sections (thus avoiding infrared divergences), with the topology of a three-sphere. After expanding the perturbations in series of eigenfunctions of the Laplace-Beltrami operator, the Hamiltonian of the system is written up to quadratic order in them. We fix the gauge of the local degrees of freedom in two different ways, reaching in both cases the same qualitative results. A canonical transformation, which includes the scaling of the matter-field perturbations by the scale factor of the geometry, is performed in order to arrive at a convenient formulation of the system. We then study the quantization of these perturbations in the classical background determined by the homogeneous variables. Based on previous work, we introduce a Fock representation for the perturbations in which: (a) the complex structure is invariant under the isometries of the spatial sections and (b) the field dynamics is implemented as a unitary operator. These two properties select not only a unique unitary equivalence class of representations, but also a preferred field description, picking up a canonical pair of field variables among all those that can be obtained by means of a time-dependent scaling of the matter field (completed into a linear canonical transformation). Finally, we present an equivalent quantization constructed in terms of gauge-invariant quantities. We prove that this quantization can be attained by a mode-by-mode time-dependent linear canonical transformation which admits a unitary implementation, so that it is also uniquely determined.

Existence and uniqueness of solution for a system of equations of ...

African Journals Online (AJOL)

The existence and uniqueness of solution for a system of equations of microwave heating of biologic issue is discussed. Using the Green function approach we establish the existence and uniqueness of solution. Journal of the Nigerian Association of Mathematical Physics Vol. 8 2004: pp. 177-180 ...

Conceptual design of a commercial accelerator driven thorium reactor

International Nuclear Information System (INIS)

Fuller, C. G.; Ashworth, R. W.

2010-01-01

This paper describes the substantial work done in underpinning and developing the concept design for a commercial 600 MWe, accelerator driven, thorium fuelled, lead cooled, power producing, fast reactor. The Accelerator Driven Thorium Reactor (ADTR TM) has been derived from original work by Carlo Rubbia. Over the period 2007 to 2009 Aker Solutions commissioned this concept design work and, in close collaboration with Rubbia, developed the physics, engineering and business model. Much has been published about the Energy Amplifier concept and accelerator driven systems. This paper concentrates on the unique physics developed during the concept study of the ADTR TM power station and the progress made in engineering and design of the system. Particular attention is paid to where the concept design has moved significantly beyond published material. Description of challenges presented for the engineering and safety of a commercial system and how they will be addressed is included. This covers the defining system parameters, accelerator sizing, core and fuel design issues and, perhaps most importantly, reactivity control. The paper concludes that the work undertaken supports the technical viability of the ADTR TM power station. Several unique features of the reactor mean that it can be deployed in countries with aspirations to gain benefit from nuclear power and, at 600 MWe, it fits a size gap for less mature grid systems. It can provide a useful complement to Generation III, III+ and IV systems through its ability to consume actinides whilst at the same time providing useful power. (authors)

The Role of Flow Experience and CAD Tools in Facilitating Creative Behaviours for Architecture Design Students

Science.gov (United States)

Dawoud, Husameddin M.; Al-Samarraie, Hosam; Zaqout, Fahed

2015-01-01

This study examined the role of flow experience in intellectual activity with an emphasis on the relationship between flow experience and creative behaviour in design using CAD. The study used confluence and psychometric approaches because of their unique abilities to depict a clear image of creative behaviour. A cross-sectional study…

Existence and uniqueness of solution for a model problem of transonic flow

International Nuclear Information System (INIS)

Tangmanee, S.

1985-11-01

A model problem of transonic flow ''the Tricomi equation'' bounded by the rectangular-curve boundary is studied. We transform the model problem into a symmetric positive system and an admissible boundary condition is posed. We show that with some conditions the existence and uniqueness of the solution are guaranteed. (author)

Extrap conceptual fusion reactor design study

International Nuclear Information System (INIS)

Eninger, J.E; Lehnert, B.

1987-12-01

A study has recently been initiated to asses the fusion reactor potential of the Extrap concept. A reactor model is defined that fulfills certain economic and environmental criteria. This model is applied to Extrap and a reference reactor is outlined. The design is optimized by varying parameters subject to both physics and engineering constraints. Several design options are examined and key engineering issues are identified and addressed. Some preliminary results and conclusions of this work are summarized. (authors)

Design study of underground facility of the Underground Research Laboratory

International Nuclear Information System (INIS)

Hibiya, Keisuke; Akiyoshi, Kenji; Ishizuka, Mineo; Anezaki, Susumu

1998-03-01

Geoscientific research program to study deep geological environment has been performed by Power Reactor and Nuclear Fuel Development Corporation (PNC). This research is supported by 'Long-Term Program for Research, Development and Utilization of Nuclear Energy'. An Underground Research Laboratory is planned to be constructed at Shoma-sama Hora in the research area belonging to PNC. A wide range of geoscientific research and development activities which have been previously studied at the Tono Area is planned in the laboratory. The Underground Research Laboratory is consisted of Surface Laboratory and Underground Research Facility located from the surface down to depth between several hundreds and 1,000 meters. Based on the results of design study in last year, the design study performed in this year is to investigate the followings in advance of studies for basic design and practical design: concept, design procedure, design flow and total layout. As a study for the concept of the underground facility, items required for the facility are investigated and factors to design the primary form of the underground facility are extracted. Continuously, design methods for the vault and the underground facility are summarized. Furthermore, design procedures of the extracted factors are summarized and total layout is studied considering the results to be obtained from the laboratory. (author)

Scissors and unique-parity modes of M1 excitation in deformed nuclei

International Nuclear Information System (INIS)

Otsuka, T.

1989-01-01

In this paper the possible modes of M1 excitation in deformed even-even nuclei are studied in terms of the particle-number-conserved Nilsson + BCS formalism with the standard parameters. The spurious motion with respect to the rotation is removed. In addition to the Scissors mode, the Unique-Parity Spin and Normal-Parity Spin modes are suggested, although the latter may be fragmented to a large extent. The Scissors mode carries most of the orbital strength, while the others the spin strength. The proton Unique-Parity (i.e. Oh 11/12 ) Spin mode for 164 Dy is obtained just below Ex = 3 MeV with B(M1) ∼ 0.2 μ 2 N ) in the sum rule limit. This is in a good agreement to the recent experimental data

A versatile electrical penetration design qualified to IEEE Std. 317-1983

International Nuclear Information System (INIS)

Lankenau, W.; Wetherill, T.M.

1994-01-01

Although worldwide demand for new construction of nuclear power stations has been on a decline, the available opportunities for the design and construction of qualified electrical penetrations continues to offer challenges, requiring a highly versatile design. Versatility is necessary in order to meet unique customer requirements within the constraints of a design basis qualified to IEEE Std. 317-1983. This paper summarizes such a versatile electrical penetration designed, built and tested to IEEE Std. 317-1983. The principal features are described including major materials of construction. Some of the design constraints such as sealing requirements, and conductor density (including numerical example) are discussed. The requirements for qualification testing of the penetration assembly to IEEE Std. 317-1983 are delineated in a general sense, and some typical test ranges for preconditioning, radiation exposure, and LOCA are provided. The paper concludes by describing ways in which this versatile design has been adapted to meet unique customer requirements in a variety of nuclear power plants

Authentic sheep meat in the European Union: Factors influencing and validating its unique meat quality.

Science.gov (United States)

Erasmus, Sara W; Muller, Magdalena; Hoffman, Louwrens C

2017-05-01

Authentic meat products are gaining attention through their unique quality characteristics linked to their origin. Various factors are known to influence the quality of fresh meat. This review describes the different Protected Designation of Origin (PDO) and Protected Geographical Indication (PGI) lamb types and discusses the factors which influences its unique sensory and chemical characteristics. Flavour, aroma, texture and colour play an integral part in the sensory quality of denomination of origin fresh meat products. For authentic fresh sheep meat the sensory (as well as chemical) quality is largely influenced by diet followed by breed, age and gender. However, diet forms the link with the geographical area of origin, which together with the traditional production system and sheep breeds used, lends the product its authentic nature. This review shows how diet linked to origin can affect the quality of the meat and furthermore how other factors such as breed can also have an effect. Research relating to the authentic lamb types were evaluated and the shortcomings highlighted in order to assist with the development of PDO and PGI specifications in the future. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

Study on integrated design and analysis platform of NPP

International Nuclear Information System (INIS)

Lu Dongsen; Gao Zuying; Zhou Zhiwei

2001-01-01

Many calculation software have been developed to nuclear system's design and safety analysis, such as structure design software, fuel design and manage software, thermal hydraulic analysis software, severe accident simulation software, etc. This study integrates those software to a platform, develops visual modeling tool for Retran, NGFM90. And in this platform, a distribution calculation method is also provided for couple calculation between different software. The study will improve the design and analysis of NPP

Inertial Fusion Energy reactor design studies: Prometheus-L, Prometheus-H

International Nuclear Information System (INIS)

Waganer, L.M.; Driemeyer, D.E.; Lee, V.D.

1992-03-01

This report contains a review of design studies for inertial confinement reactors. The first of three volumes briefly discusses the following: Introduction; Key objectives, requirements, and assumptions; Systems modeling and trade studies; Prometheus-L reactor plant design overview; Prometheus-H reactor plant design overview; Key technical issues and R ampersand D requirements; Comparison of IFE designs; and study conclusions

Uniqueness of the gauge invariant action for cosmological perturbations

International Nuclear Information System (INIS)

Prokopec, Tomislav; Weenink, Jan

2012-01-01

In second order perturbation theory different definitions are known of gauge invariant perturbations in single field inflationary models. Consequently the corresponding gauge invariant cubic actions do not have the same form. Here we show that the cubic action for one choice of gauge invariant variables is unique in the following sense: the action for any other, non-linearly related variable can be brought to the same bulk action, plus additional boundary terms. These boundary terms correspond to the choice of hypersurface and generate extra, disconnected contributions to the bispectrum. We also discuss uniqueness of the action with respect to conformal frames. When expressed in terms of the gauge invariant curvature perturbation on uniform field hypersurfaces the action for cosmological perturbations has a unique form, independent of the original Einstein or Jordan frame. Crucial is that the gauge invariant comoving curvature perturbation is frame independent, which makes it extremely helpful in showing the quantum equivalence of the two frames, and therefore in calculating quantum effects in nonminimally coupled theories such as Higgs inflation

Design for software a playbook for developers

CERN Document Server

Klimczak, Erik

2013-01-01

A unique resource to help software developers create a desirable user experience Today, top-flight software must feature a desirable user experience. This one-of-a-kind book creates a design process specifically for software, making it easy for developers who lack design background to create that compelling user experience. Appealing to both tech-savvy designers and creative-minded technologists, it establishes a hybrid discipline that will produce first-rate software. Illustrated in full color, it shows how to plan and visualize the design to create software that works on every l

CULTURE–INCLUSIVE TOILET DESIGN FOR YPAB BLIND SCHOOL IN SURABAYA

Directory of Open Access Journals (Sweden)

TANUWIDJAJA Gunawan

2014-12-01

Full Text Available Toileting culture affects the toileting design. Adaptive - inclusive toilet design strategy was needed to respond the local unique toileting culture of Surabaya people. Based on toileting culture and five Inclusive design principles directed by Tanuwidjaja, the inclusive toilet was produced. The project involved four steps such as: literature review, interview and photo documents, participative design workshops and design development. Therefore, a final design was produced and found acceptable for Surabaya people.

A proven twin header design for small PWRs

International Nuclear Information System (INIS)

Davidov, Maurice

1987-01-01

A unique design of PWR steam generator, developed by Foster Wheeler in Britain more than 30 years ago, avoids the problem of tubesheet sludge accumulation. The twin header steam generator uses a vertical, inverted U-tube bundle connected to cylindrical inlet and outlet headers. The advantages of the design and operating experience are outlined. (author)

Uniqueness of Gibbs states and global Markov property for Euclidean fields

International Nuclear Information System (INIS)

Albeverio, S.; Hoeegh-Krohn, R.

1981-01-01

The authors briefly discuss the proof of the uniqueness of solutions of the DLR equations (uniqueness of Gibbs states) in the class of regular generalized random fields (in the sense of having second moments bounded by those of some Euclidean field), for the Euclidean fields with trigonometric interaction. (Auth.)

Is subjective social status a unique correlate of physical health? A meta-analysis.

Science.gov (United States)

Cundiff, Jenny M; Matthews, Karen A

2017-12-01

Both social stratification (e.g., social rank) as well as economic resources (e.g., income) are thought to contribute to socioeconomic health disparities. It has been proposed that subjective socioeconomic status (an individual's perception of his or her hierarchical rank) provides increased predictive utility for physical health over and above more traditional, well-researched socioeconomic constructs such as education, occupation, and income. PsycINFO and PubMed databases were systematically searched for studies examining the association of subjective socioeconomic status (SES) and physical health adjusting for at least 1 measure of objective SES. The final sample included 31 studies and 99 unique effects. Meta-analyses were performed to: (a) estimate the overlap among subjective and objective indicators of SES and (b) estimate the cumulative association of subjective SES with physical health adjusting for objective SES. Potential moderators such as race and type of health indicator assessed (global self-reports vs. more specific and biologically based indicators) were also examined. Across samples, subjective SES shows moderate overlap with objective indicators of SES, but associations are much stronger in Whites than Blacks. Subjective SES evidenced a unique cumulative association with physical health in adults, above and beyond traditional objective indicators of SES (Z = .07, SE = .01, p Subjective SES may provide unique information relevant to understanding disparities in health, especially self-rated health. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Design thinking for website optimization. A case study

DEFF Research Database (Denmark)

Somoza Sanchez, Vella Veronica; Andersen, Frederik; Schneider-Kamp, Peter

This paper presents results from a pilot study, which is part of a larger research project where we study the process innovation of website optimization as a service through the use of big data. Over a process of design thinking we investigate which type of website design best addresses the needs...... for observing the users in their native environment. Furthermore, we use the method of Digital Anthropology to complete the loop between the human-centric designs and the possibilities offered by the analysis of big data....

Marketing the Uniqueness of Small Towns. Revised.

Science.gov (United States)

Dunn, Douglas; Hogg, David H.

The key to marketing a town is determining and promoting the town's "differential advantage" or uniqueness that would make people want to visit or live there. Exercises to help communities gain important insights into the town's competitive edge include a brainstorming session with knowledgeable community members, a visitor…

Arab Teens Lifestyle Study (ATLS): objectives, design, methodology and implications.

Science.gov (United States)

Al-Hazzaa, Hazzaa M; Musaiger, Abdulrahman O

2011-01-01

There is a lack of comparable data on physical activity, sedentary behavior, and dietary habits among Arab adolescents, which limits our understanding and interpretation of the relationship between obesity and lifestyle parameters. Therefore, we initiated the Arab Teens Lifestyle Study (ATLS). The ATLS is a multicenter collaborative project for assessing lifestyle habits of Arab adolescents. The objectives of the ATLS project were to investigate the prevalence rates for overweight and obesity, physical activity, sedentary activity and dietary habits among Arab adolescents, and to examine the interrelationships between these lifestyle variables. This paper reports on the objectives, design, methodology, and implications of the ATLS. The ATLS is a school-based cross-sectional study involving 9182 randomly selected secondary-school students (14-19 years) from major Arab cities, using a multistage stratified sampling technique. The participating Arab cities included Riyadh, Jeddah, and Al-Khobar (Saudi Arabia), Bahrain, Dubai (United Arab Emirates), Kuwait, Amman (Jordan), Mosel (Iraq), Muscat (Oman), Tunisia (Tunisia) and Kenitra (Morocco). Measured variables included anthropometric measurements, physical activity, sedentary behavior, sleep duration, and dietary habits. The ATLS project will provide a unique opportunity to collect and analyze important lifestyle information from Arab adolescents using standardized procedures. This is the first time a collaborative Arab project will simultaneously assess broad lifestyle variables in a large sample of adolescents from numerous urbanized Arab regions. This joint research project will supply us with comprehensive and recent data on physical activity/inactivity and eating habits of Arab adolescents relative to obesity. Such invaluable lifestyle-related data are crucial for developing public health policies and regional strategies for health promotion and disease prevention.

Unique phytochrome responses of the holoparasitic plant Orobanche minor.

Science.gov (United States)

Takagi, Kazuteru; Okazawa, Atsushi; Wada, Yu; Mongkolchaiyaphruek, Anchaya; Fukusaki, Eiichiro; Yoneyama, Koichi; Takeuchi, Yasutomo; Kobayashi, Akio

2009-06-01

Holoparasitic plants such as Orobanche spp. have lost their photosynthetic ability, so photoresponses to optimize photosynthesis are not necessary in these plants. Photoresponses are also involved in the regulation of plant development but the photoresponses of holoparasites have not been characterized in detail. In this study, the phytochrome (phy)-related photoresponse of Orobanche minor was investigated. Its photoreceptor, phytochrome A (OmphyA), was also characterized. Light effects on germination, shoot elongation, anthocyanin biosynthesis, and OmphyA expression and subcellular localization were analyzed. Red light (R):far-red light (FR) reversible inhibition of O. minor seed germination demonstrated that phy-mediated responses are retained in this holoparasite. Shoot elongation was inhibited by FR but not by R. This pattern is unique among known patterns of plant photoresponses. Additionally, molecular analysis showed that OmphyA is able to respond to the light signals. Interestingly, the unique pattern of photoresponses in O. minor seems to have been modified for adaptation to its parasitic life cycle. We hypothesize that this alteration has resulted from the loss or alteration of some phy-signaling components. Elucidation of altered components in phy signaling in this parasite will provide useful information not only about its physiological characteristics but also about general plant photoreception systems.

Efficient Serial and Parallel Algorithms for Selection of Unique Oligos in EST Databases.

Science.gov (United States)

Mata-Montero, Manrique; Shalaby, Nabil; Sheppard, Bradley

2013-01-01

Obtaining unique oligos from an EST database is a problem of great importance in bioinformatics, particularly in the discovery of new genes and the mapping of the human genome. Many algorithms have been developed to find unique oligos, many of which are much less time consuming than the traditional brute force approach. An algorithm was presented by Zheng et al. (2004) which finds the solution of the unique oligos search problem efficiently. We implement this algorithm as well as several new algorithms based on some theorems included in this paper. We demonstrate how, with these new algorithms, we can obtain unique oligos much faster than with previous ones. We parallelize these new algorithms to further improve the time of finding unique oligos. All algorithms are run on ESTs obtained from a Barley EST database.

RF quadrupole beam dynamics design studies

International Nuclear Information System (INIS)

Crandall, K.R.; Stokes, R.H.; Wangler, T.P.

1979-01-01

The radio-frequency quadrupole (RFQ) linear accelerator structure is expected to permit considerable flexibility in achieving linac design objectives at low velocities. Calculational studies show that the RFQ can accept a high-current, low-velocity, dc beam, bunch it with high efficiency, and accelerate it to a velocity suitable for injection into a drift-tube linac. Although it is relatively easy to generate a satisfactory design for an RFQ linac for low beam currents, the space-charge effects produced by high currents dominate the design criteria. Methods have been developed to generate solutions that make suitable compromises between the effects of emittance growth, transmission efficiency, and overall structure length. Results are given for a test RFQ linac operating at 425 MHz

A unique Fock quantization for fields in non-stationary spacetimes

International Nuclear Information System (INIS)

Cortez, Jerónimo; Marugán, Guillermo A. Mena; Olmedo, Javier; Velhinho, José M.

2010-01-01

In curved spacetimes, the lack of criteria for the construction of a unique quantization is a fundamental problem undermining the significance of the predictions of quantum field theory. Inequivalent quantizations lead to different physics. Recently, however, some uniqueness results have been obtained for fields in non-stationary settings. In particular, for vacua that are invariant under the background symmetries, a unitary implementation of the classical evolution suffices to pick up a unique Fock quantization in the case of Klein-Gordon fields with time-dependent mass, propagating in a static spacetime whose spatial sections are three-spheres. In fact, the field equation can be reinterpreted as describing the propagation in a Friedmann-Robertson-Walker spacetime after a suitable scaling of the field by a function of time. For this class of fields, we prove here an even stronger result about the Fock quantization: the uniqueness persists when one allows for linear time-dependent transformations of the field in order to account for a scaling by background functions. In total, paying attention to the dynamics, there exists a preferred choice of quantum field, and only one SO(4)-invariant Fock representation for it that respects the standard probabilistic interpretation along the evolution. The result has relevant implications e.g. in cosmology