WorldWideScience

Sample records for unique structural hierarchy

  1. Hamiltonian Structure of PI Hierarchy

    Directory of Open Access Journals (Sweden)

    Kanehisa Takasaki

    2007-03-01

    Full Text Available The string equation of type (2,2g+1 may be thought of as a higher order analogue of the first Painlevé equation that corresponds to the case of g = 1. For g > 1, this equation is accompanied with a finite set of commuting isomonodromic deformations, and they altogether form a hierarchy called the PI hierarchy. This hierarchy gives an isomonodromic analogue of the well known Mumford system. The Hamiltonian structure of the Lax equations can be formulated by the same Poisson structure as the Mumford system. A set of Darboux coordinates, which have been used for the Mumford system, can be introduced in this hierarchy as well. The equations of motion in these Darboux coordinates turn out to take a Hamiltonian form, but the Hamiltonians are different from the Hamiltonians of the Lax equations (except for the lowest one that corresponds to the string equation itself.

  2. Periodic Hamiltonian hierarchies and non-uniqueness of superpotentials

    Indian Academy of Sciences (India)

    PARTHA MANDAL; ABHIJIT BANERJEE

    2017-01-01

    In this article, a family of periodic quantum Hamiltonians, that is subject to a closure condition is considered. In the context of the factorization method, we address the question of non-uniqueness of the governing superpotentials and study an alternative factorization to generate new hierarchies of potentials.

  3. Size structures sensory hierarchy in ocean life

    DEFF Research Database (Denmark)

    Martens, Erik Andreas; Wadhwa, Navish; Jacobsen, Nis Sand

    2015-01-01

    the use of remote sensing. In this study, we explore how sensing mode and range depend on body size. We reveal a hierarchy of sensing modes (chemosensing, mechanosensing, vision, hearing, and echolocation) where body size determines the available battery of sensing modes and where larger body size means...... a longer sensing range. The size-dependent hierarchy and the transitions between primary sensory modes are explained on the grounds of limiting factors set by physiology and the physical laws governing signal generation, transmission and reception. We characterize the governing mechanisms and theoretically...... predict the body size limits for various sensory modes, which align very well with size ranges found in literature. The treatise of all ocean life, from unicellular organisms to whales, demonstrates how body size determines available sensing modes, and thereby acts as a major structuring factor of aquatic...

  4. Size structures sensory hierarchy in ocean life.

    Science.gov (United States)

    Martens, Erik A; Wadhwa, Navish; Jacobsen, Nis S; Lindemann, Christian; Andersen, Ken H; Visser, André

    2015-09-22

    Survival in aquatic environments requires organisms to have effective means of collecting information from their surroundings through various sensing strategies. In this study, we explore how sensing mode and range depend on body size. We find a hierarchy of sensing modes determined by body size. With increasing body size, a larger battery of modes becomes available (chemosensing, mechanosensing, vision, hearing and echolocation, in that order) while the sensing range also increases. This size-dependent hierarchy and the transitions between primary sensory modes are explained on the grounds of limiting factors set by physiology and the physical laws governing signal generation, transmission and reception. We theoretically predict the body size limits for various sensory modes, which align well with size ranges found in literature. The treatise of all ocean life, from unicellular organisms to whales, demonstrates how body size determines available sensing modes, and thereby acts as a major structuring factor of aquatic life. © 2015 The Author(s).

  5. Structural hierarchy governs fibrin gel mechanics.

    Science.gov (United States)

    Piechocka, Izabela K; Bacabac, Rommel G; Potters, Max; Mackintosh, Fred C; Koenderink, Gijsje H

    2010-05-19

    Fibrin gels are responsible for the mechanical strength of blood clots, which are among the most resilient protein materials in nature. Here we investigate the physical origin of this mechanical behavior by performing rheology measurements on reconstituted fibrin gels. We find that increasing levels of shear strain induce a succession of distinct elastic responses that reflect stretching processes on different length scales. We present a theoretical model that explains these observations in terms of the unique hierarchical architecture of the fibers. The fibers are bundles of semiflexible protofibrils that are loosely connected by flexible linker chains. This architecture makes the fibers 100-fold more flexible to bending than anticipated based on their large diameter. Moreover, in contrast with other biopolymers, fibrin fibers intrinsically stiffen when stretched. The resulting hierarchy of elastic regimes explains the incredible resilience of fibrin clots against large deformations.

  6. Hamiltonian and Godunov Structures of the Grad Hierarchy

    CERN Document Server

    Grmela, Miroslav; Jou, David; Lebon, Georgy; Pavelka, Michal

    2016-01-01

    The time evolution governed by the Boltzmann kinetic equation is compatible with mechanics and thermodynamics. The former compatibility is mathematically expressed in the Hamiltonian and Godunov structures, the latter in the structure of gradient dynamics guaranteeing the growth of entropy and consequently the approach to equilibrium. We carry all three structures to the Grad reformulation of the Boltzmann equation (to the Grad hierarchy). First, we recognize the structures in the infinite Grad hierarchy and then in several examples of finite hierarchies representing extended hydrodynamic equations. In the context of Grad's hierarchies we also investigate relations between Hamiltonian and Godunov structures.

  7. The Academic Structure in Japan: Institutional Hierarchy and Academic Mobility.

    Science.gov (United States)

    Arimoto, Akira

    The characteristics of the Japanese academic structure are examined with attention to the evolution of institutional hierarchy, the closed academic structure, and the effects of the academic structure upon academic research. The evolution of Japan's institutional hierarchy in academics has been tightly related to factors of nationalism,…

  8. OPTIMAL HIERARCHY STRUCTURES FOR MULTI-ATTRIBUTE-CRITERIA DECISIONS

    Institute of Scientific and Technical Information of China (English)

    Stan LIPOVETSKY

    2009-01-01

    A problem of a hierarchy structure optimization is considered. Hierarchical structures are widely used in the Analytic Hierarchy Process, conjoint analysis, and various other methods of multiple criteria decision making. The problem consists in finding a structure that needs a minimum number of pair comparisons for a given total number of the alternatives. For an optimal hierarchy, the minimum efforts are needed for eliciting data and synthesizing the local References across the hierarchy to get the global priorities or utilities. Special estimation techniques are developed and numerical simulations performed. Analytical and numerical results suggest optimal ways of priority evaluations for practical managerial decisions in a complex environment.

  9. Integrable Coupling of KN Hierarchy and Its Hamiltonian Structure

    Institute of Scientific and Technical Information of China (English)

    GUO Fu-Kui; ZHANG Yu-Feng

    2006-01-01

    The Hamiltonian structure of the integrable couplings obtained by our method has not been solved. In this paper, the Hamiltonian structure of the KN hierarchy is obtained by making use of the quadratic-form identity.

  10. Hamiltonian Structures for the Generalized Dispersionless KdV Hierarchy

    OpenAIRE

    Brunelli, J. C.

    1996-01-01

    We study from a Hamiltonian point of view the generalized dispersionless KdV hierarchy of equations. From the so called dispersionless Lax representation of these equations we obtain three compatible Hamiltonian structures. The second and third Hamiltonian structures are calculated directly from the r-matrix approach. Since the third structure is not related recursively with the first two ones the generalized dispersionless KdV hierarchy can be characterized as a truly tri-Hamiltonian system.

  11. INTEGRABLE COUPLINGS OF THE TB HIERARCHY AND ITS HAMILTONIAN STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper,we obtain integrable couplings of the TB hierarchy using the new subalgebra of the loop algebra A_3.Then the Hamiltonian structure of the above system is given by the quadratic-form identity.

  12. Fibrous Protein Structures: Hierarchy, History and Heroes.

    Science.gov (United States)

    Squire, John M; Parry, David A D

    2017-01-01

    During the 1930s and 1940s the technique of X-ray diffraction was applied widely by William Astbury and his colleagues to a number of naturally-occurring fibrous materials. On the basis of the diffraction patterns obtained, he observed that the structure of each of the fibres was dominated by one of a small number of different types of molecular conformation. One group of fibres, known as the k-m-e-f group of proteins (keratin - myosin - epidermin - fibrinogen), gave rise to diffraction characteristics that became known as the α-pattern. Others, such as those from a number of silks, gave rise to a different pattern - the β-pattern, while connective tissues yielded a third unique set of diffraction characteristics. At the time of Astbury's work, the structures of these materials were unknown, though the spacings of the main X-ray reflections gave an idea of the axial repeats and the lateral packing distances. In a breakthrough in the early 1950s, the basic structures of all of these fibrous proteins were determined. It was found that the long protein chains, composed of strings of amino acids, could be folded up in a systematic manner to generate a limited number of structures that were consistent with the X-ray data. The most important of these were known as the α-helix, the β-sheet, and the collagen triple helix. These studies provided information about the basic building blocks of all proteins, both fibrous and globular. They did not, however, provide detailed information about how these molecules packed together in three-dimensions to generate the fibres found in vivo. A number of possible packing arrangements were subsequently deduced from the X-ray diffraction and other data, but it is only in the last few years, through the continued improvements of electron microscopy, that the packing details within some fibrous proteins can now be seen directly. Here we outline briefly some of the milestones in fibrous protein structure determination, the role of the

  13. The quadratic-form identity for constructing Hamiltonian structures of the Guo hierarchy

    Institute of Scientific and Technical Information of China (English)

    Dong Huan-He; Zhang Ning

    2006-01-01

    The trace identity is extended to the quadratic-form identity. The Hamiltonian structures of the multi-component Guo hierarchy, integrable coupling of Guo hierarchy and (2+1)-dimensional Guo hierarchy are obtained by the quadraticform identity. The method can be used to produce the Hamiltonian structures of the other integrable couplings or multi-component hierarchies.

  14. Global network structure of dominance hierarchy of ant workers.

    Science.gov (United States)

    Shimoji, Hiroyuki; Abe, Masato S; Tsuji, Kazuki; Masuda, Naoki

    2014-10-06

    Dominance hierarchy among animals is widespread in various species and believed to serve to regulate resource allocation within an animal group. Unlike small groups, however, detection and quantification of linear hierarchy in large groups of animals are a difficult task. Here, we analyse aggression-based dominance hierarchies formed by worker ants in Diacamma sp. as large directed networks. We show that the observed dominance networks are perfect or approximate directed acyclic graphs, which are consistent with perfect linear hierarchy. The observed networks are also sparse and random but significantly different from networks generated through thinning of the perfect linear tournament (i.e. all individuals are linearly ranked and dominance relationship exists between every pair of individuals). These results pertain to global structure of the networks, which contrasts with the previous studies inspecting frequencies of different types of triads. In addition, the distribution of the out-degree (i.e. number of workers that the focal worker attacks), not in-degree (i.e. number of workers that attack the focal worker), of each observed network is right-skewed. Those having excessively large out-degrees are located near the top, but not the top, of the hierarchy. We also discuss evolutionary implications of the discovered properties of dominance networks. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

  15. A Complex Integrable Hierarchy and Its Hamiltonian Structure for Integrable Couplings of WKI Soliton Hierarchy

    Directory of Open Access Journals (Sweden)

    Fajun Yu

    2014-01-01

    Full Text Available We generate complex integrable couplings from zero curvature equations associated with matrix spectral problems in this paper. A direct application to the WKI spectral problem leads to a novel soliton equation hierarchy of integrable coupling system; then we consider the Hamiltonian structure of the integrable coupling system. We select the U¯, V¯ and generate the nonlinear composite parts, which generate new extended WKI integrable couplings. It is also indicated that the method of block matrix is an efficient and straightforward way to construct the integrable coupling system.

  16. Structural Measures to Track the Evolution of SNOMED CT Hierarchies

    Science.gov (United States)

    Wei, Duo; Gu, Huanying (Helen); Perl, Yehoshua; Halper, Michael; Ochs, Christopher; Elhanan, Gai; Chen, Yan

    2015-01-01

    The Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT) is an extensive reference terminology with an attendant amount of complexity. It has been updated continuously and revisions have been released semi-annually to meet users’ needs and to reflect the results of quality assurance (QA) activities. Two measures based on structural features are proposed to track the effects of both natural terminology growth and QA activities based on aspects of the complexity of SNOMED CT. These two measures, called the structural density measure and accumulated structural measure, are derived based on two abstraction networks, the area taxonomy and the partial-area taxonomy. The measures derive from attribute relationship distributions and various concept groupings that are associated with the abstraction networks. They are used to track the trends in the complexity of structures as SNOMED CT changes over time. The measures were calculated for consecutive releases of five SNOMED CT hierarchies, including the Specimen hierarchy. The structural density measure shows that natural growth tends to move a hierarchy’s structure toward a more complex state, whereas the accumulated structural measure shows that QA processes tend to move a hierarchy’s structure toward a less complex state. It is also observed that both the structural density and accumulated structural measures are useful tools to track the evolution of an entire SNOMED CT hierarchy and reveal internal concept migration within it. PMID:26260003

  17. Causal structure and hierarchies of models.

    Science.gov (United States)

    Hoover, Kevin D

    2012-12-01

    Economics prefers complete explanations: general over partial equilibrium, microfoundational over aggregate. Similarly, probabilistic accounts of causation frequently prefer greater detail to less as in typical resolutions of Simpson's paradox. Strategies of causal refinement equally aim to distinguish direct from indirect causes. Yet, there are countervailing practices in economics. Representative-agent models aim to capture economic motivation but not to reduce the level of aggregation. Small structural vector-autoregression and dynamic stochastic general-equilibrium models are practically preferred to larger ones. The distinction between exogenous and endogenous variables suggests partitioning the world into distinct subsystems. The tension in these practices is addressed within a structural account of causation inspired by the work of Herbert Simon's, which defines cause with reference to complete systems adapted to deal with incomplete systems and piecemeal evidence. The focus is on understanding the constraints that a structural account of causation places on the freedom to model complex or lower-order systems as simpler or higher-order systems and on to what degree piecemeal evidence can be incorporated into a structural account.

  18. A Hierarchy of Tree-Automatic Structures

    CERN Document Server

    Finkel, Olivier

    2011-01-01

    We consider $\\omega^n$-automatic structures which are relational structures whose domain and relations are accepted by automata reading ordinal words of length $\\omega^n$ for some integer $n\\geq 1$. We show that all these structures are $\\omega$-tree-automatic structures presentable by Muller or Rabin tree automata. We prove that the isomorphism relation for $\\omega^2$-automatic (resp. $\\omega^n$-automatic for $n>2$) boolean algebras (respectively, partial orders, rings, commutative rings, non commutative rings, non commutative groups) is not determined by the axiomatic system ZFC. We infer from the proof of the above result that the isomorphism problem for $\\omega^n$-automatic boolean algebras, $n > 1$, (respectively, rings, commutative rings, non commutative rings, non commutative groups) is neither a $\\Sigma_2^1$-set nor a $\\Pi_2^1$-set. We obtain that there exist infinitely many $\\omega^n$-automatic, hence also $\\omega$-tree-automatic, atomless boolean algebras $B_n$, $n\\geq 1$, which are pairwise isomorp...

  19. Structural hierarchy of autism spectrum disorder symptoms: an integrative framework.

    Science.gov (United States)

    Kim, Hyunsik; Keifer, Cara M; Rodriguez-Seijas, Craig; Eaton, Nicholas R; Lerner, Matthew D; Gadow, Kenneth D

    2017-02-14

    In an attempt to resolve questions regarding the symptom classification of autism spectrum disorder (ASD), previous research generally aimed to demonstrate superiority of one model over another. Rather than adjudicating which model may be optimal, we propose an alternative approach that integrates competing models using Goldberg's bass-ackwards method, providing a comprehensive understanding of the underlying symptom structure of ASD. The study sample comprised 3,825 individuals, consecutive referrals to a university hospital developmental disabilities specialty clinic or a child psychiatry outpatient clinic. This study analyzed DSM-IV-referenced ASD symptom statements from parent and teacher versions of the Child and Adolescent Symptom Inventory-4R. A series of exploratory structural equation models was conducted in order to produce interpretable latent factors that account for multivariate covariance. Results indicated that ASD symptoms were structured into an interpretable hierarchy across multiple informants. This hierarchy includes five levels; key features of ASD bifurcate into different constructs with increasing specificity. This is the first study to examine an underlying structural hierarchy of ASD symptomatology using the bass-ackwards method. This hierarchy demonstrates how core features of ASD relate at differing levels of resolution, providing a model for conceptualizing ASD heterogeneity and a structure for integrating divergent theories of cognitive processes and behavioral features that define the disorder. These findings suggest that a more coherent and complete understanding of the structure of ASD symptoms may be reflected in a metastructure rather than at one level of resolution. © 2017 Association for Child and Adolescent Mental Health.

  20. Improving resource utilization in hierarchy network by optimizing topological structure

    Science.gov (United States)

    Liu, G. L.; Peng, H. P.; Li, L. X.; Sun, F.; Yang, Y. X.

    2012-02-01

    We study the performance of peer-to-peer (P2P) network built on the top of hierarchy topological structure of local area networks (LAN). We find that the topological structure of the underlying physical network has significant impacts on the resource utilization of the P2P overlay network. The larger size of the physical network is, the lower resource utilization of the overlay network is. Through optimizing the topological structure of physical network, we propose two novel schemes to improve the resource utilization. The experimental results show that in any case the resource utilization of P2P network can always achieve 100% by these two schemes.

  1. Seeking structure in social organization: compensatory control and the psychological advantages of hierarchy.

    Science.gov (United States)

    Friesen, Justin P; Kay, Aaron C; Eibach, Richard P; Galinsky, Adam D

    2014-04-01

    Hierarchies are a ubiquitous form of human social organization. We hypothesized that 1 reason for the prevalence of hierarchies is that they offer structure and therefore satisfy the core motivational needs for order and control relative to less structured forms of social organization. This hypothesis is rooted in compensatory control theory, which posits that (a) individuals have a basic need to perceive the world as orderly and structured, and (b) personal and external sources of control are capable of satisfying this need because both serve the comforting belief that the world operates in an orderly fashion. Our first 2 studies confirmed that hierarchies were perceived as more structured and orderly relative to egalitarian arrangements (Study 1) and that working in a hierarchical workplace promotes a feeling of self-efficacy (Study 2). We threatened participants' sense of personal control and measured perceptions of and preferences for hierarchy in 5 subsequent experiments. Participants who lacked control perceived more hierarchy occurring in ambiguous social situations (Study 3) and preferred hierarchy more strongly in workplace contexts (Studies 4-5). We also provide evidence that hierarchies are indeed appealing because of their structure: Preference for hierarchy was higher among individuals high in Personal Need for Structure and a control threat increased preference for hierarchy even among participants low in Personal Need for Structure (Study 5). Framing a hierarchy as unstructured reversed the effect of control threat on hierarchy (Study 6). Finally, hierarchy-enhancing jobs were more appealing after control threat, even when they were low in power and status (Study 7). (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  2. Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.

    Science.gov (United States)

    Parker, Kevin K; Ingber, Donald E

    2007-08-29

    The spatial and temporal scales of cardiac organogenesis and pathogenesis make engineering of artificial heart tissue a daunting challenge. The temporal scales range from nanosecond conformational changes responsible for ion channel opening to fibrillation which occurs over seconds and can lead to death. Spatial scales range from nanometre pore sizes in membrane channels and gap junctions to the metre length scale of the whole cardiovascular system in a living patient. Synchrony over these scales requires a hierarchy of control mechanisms that are governed by a single common principle: integration of structure and function. To ensure that the function of ion channels and contraction of muscle cells lead to changes in heart chamber volume, an elegant choreography of metabolic, electrical and mechanical events are executed by protein networks composed of extracellular matrix, transmembrane integrin receptors and cytoskeleton which are functionally connected across all size scales. These structural control networks are mechanoresponsive, and they process mechanical and chemical signals in a massively parallel fashion, while also serving as a bidirectional circuit for information flow. This review explores how these hierarchical structural networks regulate the form and function of living cells and tissues, as well as how microfabrication techniques can be used to probe this structural control mechanism that maintains metabolic supply, electrical activation and mechanical pumping of heart muscle. Through this process, we delineate various design principles that may be useful for engineering artificial heart tissue in the future.

  3. Nonlinear Super Integrable Couplings of Super Dirac Hierarchy and Its Super Hamiltonian Structures

    Institute of Scientific and Technical Information of China (English)

    尤福财

    2012-01-01

    We construct nonlinear super integrable couplings of the super integrable Dirac hierarchy based on an enlarged matrix Lie superalgebra. Then its super Hamiltonian structure is furnished by super trace identity. As its reduction, we gain the nonlinear integrable couplings of the classical integrable Dirac hierarchy.

  4. New integrable lattice hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Pickering, Andrew [Area de Matematica Aplicada, ESCET, Universidad Rey Juan Carlos, c/ Tulipan s/n, 28933 Mostoles, Madrid (Spain); Zhu Zuonong [Departamento de Matematicas, Universidad de Salamanca, Plaza de la Merced 1, 37008 Salamanca (Spain) and Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200030 (China)]. E-mail: znzhu2@yahoo.com.cn

    2006-01-23

    In this Letter we give a new integrable four-field lattice hierarchy, associated to a new discrete spectral problem. We obtain our hierarchy as the compatibility condition of this spectral problem and an associated equation, constructed herein, for the time-evolution of eigenfunctions. We consider reductions of our hierarchy, which also of course admit discrete zero curvature representations, in detail. We find that our hierarchy includes many well-known integrable hierarchies as special cases, including the Toda lattice hierarchy, the modified Toda lattice hierarchy, the relativistic Toda lattice hierarchy, and the Volterra lattice hierarchy. We also obtain here a new integrable two-field lattice hierarchy, to which we give the name of Suris lattice hierarchy, since the first equation of this hierarchy has previously been given by Suris. The Hamiltonian structure of the Suris lattice hierarchy is obtained by means of a trace identity formula.

  5. Hierarchy in industrial structure: The cases of China and the USA

    Science.gov (United States)

    Hu, Fei; Zhao, Shangmei; Bing, Tao; Chang, Yiming

    2017-03-01

    Although several studies have investigated the industrial structure from the perspective of network, the focus is mainly on the identification of key sectors, and little is known about the hierarchical structure, and its impact on economic performance. Using the World Input-Output Tables (WIOTs), this paper performs a comparative study of the hierarchy in industrial structures of China and the USA. Specifically, the hierarchy is generally confirmed in the networks of industrial structure, although in different levels for China and the USA: the level of hierarchy in industrial structure of the USA is much higher than that of China. To intuitively comprehend the evolution over time in a much visualized way, we also present the backbone network of industrial structure via minimum spanning tree (MST), leading to interesting insights about the origins of hierarchy. Further, the impact of the hierarchy in network on economic performance is also explored, and the result suggests that a hierarchy of a moderate range might be better for economic growth.

  6. Hamiltonian Structures and Integrability for a Discrete Coupled KdV-Type Equation Hierarchy

    Institute of Scientific and Technical Information of China (English)

    ZHAO Hai-Qiong; ZHU Zuo-Nong; ZHANG Jing-Li

    2011-01-01

    @@ Coupled Korteweg-de Vries(KdV) systems have many important physical applications.By considering a 4 × 4spectral problem,we derive a discrete coupled KdV-type equation hierarchy.Our hierarchy includes the coupled Volterra system proposed by Lou et al.(e-print arXiv:0711.0420) as the first member which is a discrete version of the coupled KdV equation.We also investigate the integrability in the Liouville sense and the multi-Hamiltonian structures for the obtained hierarchy.%Coupled Korteweg-de Vries (KdV) systems have many important physical applications.By considering a 4 × 4 spectral problem, we derive a discrete coupled KdV-type equation hierarchy.Our hierarchy includes the coupled Volterra system proposed by Lou et al.(e-print arXiv: 0711.0420) as the first member which is a discrete version of the coupled KdV equation.We also investigate the integrability in the Liouville sense and the multi-Hamiltonian structures for the obtained hierarchy.

  7. Bi-Hamiltonian structure of the $N=2$ supersymmetric $\\alpha = 1$ KdV hierarchy

    NARCIS (Netherlands)

    Kersten, P.H.M.; Sorin, A.S.

    2002-01-01

    The $N=2$ supersymmetric ${\\alpha}=1$ KdV hierarchy in $N=2$ superspace is considered and its rich symmetry structure is uncovered. New nonpolynomial and nonlocal, bosonic and fermionic symmetries and Hamiltonians, bi-Hamiltonian structure as well as a recursion operator connecting all symmetries an

  8. Bi-Hamiltonian structure of the N=2 supersymmetric α=1 KdV hierarchy

    NARCIS (Netherlands)

    Kersten, P.H.M.; Sorin, A.S.

    2002-01-01

    The N=2 supersymmetric α=1 KdV hierarchy in N=2 superspace is considered and its rich symmetry structure is uncovered. New nonpolynomial and nonlocal, bosonic and fermionic symmetries and Hamiltonians, bi-Hamiltonian structure as well as a recursion operator connecting all symmetries and Hamiltonian

  9. Lagrangian and Hamiltonian structures in an integrable hierarchy and space-time duality

    CERN Document Server

    Avan, Jean; Doikou, Anastasia; Kundu, Anjan

    2016-01-01

    We define and illustrate the novel notion of dual integrable hierarchies, on the example of the nonlinear Schr\\"odinger (NLS) hierarchy. For each integrable nonlinear evolution equation (NLEE) in the hierarchy, dual integrable structures are characterized by the fact that the zero-curvature representation of the NLEE can be realized by two Hamiltonian formulations stemming from two inequivalent Poisson structures and two distinct Hamiltonians. This is different from the standard bi-Hamiltonian structure. One is well-known and based on the standard Poisson structure for NLS. The other one is new and based on a different Poisson structure at each level of the hierarchy, yielding the corresponding NLEE as a {\\it space} evolution equation. We emphasize the role of the Lagrangian formulation as a unifying framework for deriving both Poisson structures, using ideas from covariant field theory. One of our main results is to show that the two matrices of the Lax pair satisfy the same form of ultralocal Poisson algebr...

  10. Lagrangian and Hamiltonian structures in an integrable hierarchy and space–time duality

    Energy Technology Data Exchange (ETDEWEB)

    Avan, Jean, E-mail: Jean.Avan@u-cergy.fr [Laboratoire de Physique Théorique et Modélisation (CNRS UMR 8089), Université de Cergy-Pontoise, F-95302 Cergy-Pontoise (France); Caudrelier, Vincent, E-mail: v.caudrelier@city.ac.uk [Department of Mathematics, City University London, Northampton Square, EC1V 0HB London (United Kingdom); Doikou, Anastasia, E-mail: A.Doikou@hw.ac.uk [Department of Mathematics, Heriot-Watt University, EH14 4AS, Edinburgh (United Kingdom); Kundu, Anjan, E-mail: Anjan.Kundu@saha.ac.in [Saha Institute of Nuclear Physics, Theory Division, Kolkata (India)

    2016-01-15

    We define and illustrate the novel notion of dual integrable hierarchies, on the example of the nonlinear Schrödinger (NLS) hierarchy. For each integrable nonlinear evolution equation (NLEE) in the hierarchy, dual integrable structures are characterized by the fact that the zero-curvature representation of the NLEE can be realized by two Hamiltonian formulations stemming from two distinct choices of the configuration space, yielding two inequivalent Poisson structures on the corresponding phase space and two distinct Hamiltonians. This is fundamentally different from the standard bi-Hamiltonian or generally multitime structure. The first formulation chooses purely space-dependent fields as configuration space; it yields the standard Poisson structure for NLS. The other one is new: it chooses purely time-dependent fields as configuration space and yields a different Poisson structure at each level of the hierarchy. The corresponding NLEE becomes a space evolution equation. We emphasize the role of the Lagrangian formulation as a unifying framework for deriving both Poisson structures, using ideas from covariant field theory. One of our main results is to show that the two matrices of the Lax pair satisfy the same form of ultralocal Poisson algebra (up to a sign) characterized by an r-matrix structure, whereas traditionally only one of them is involved in the classical r-matrix method. We construct explicit dual hierarchies of Hamiltonians, and Lax representations of the triggered dynamics, from the monodromy matrices of either Lax matrix. An appealing procedure to build a multi-dimensional lattice of Lax pair, through successive uses of the dual Poisson structures, is briefly introduced.

  11. New DLW Hierarchy of an Integrable Coupling and Its Harniltonian Structure

    Institute of Scientific and Technical Information of China (English)

    LIN Chang; LIN Mai-Mai

    2011-01-01

    A type of higher-dimensional loop algebra is constructed from which an isospectral problem is established.It follows that an integrable coupling, actually an extended integrable model of the existed solitary hierarchy of equations,is obtained by taking use of the zero curvature equation, whose Hamiltonian structure is worked out by employing the constructed quadratic identity.

  12. Super-Hamiltonian Structures and Conservation Laws of a New Six-Component Super-Ablowitz-Kaup-Newell-Segur Hierarchy

    Directory of Open Access Journals (Sweden)

    Fucai You

    2014-01-01

    Full Text Available A six-component super-Ablowitz-Kaup-Newell-Segur (-AKNS hierarchy is proposed by the zero curvature equation associated with Lie superalgebras. Supertrace identity is used to furnish the super-Hamiltonian structures for the resulting nonlinear superintegrable hierarchy. Furthermore, we derive the infinite conservation laws of the first two nonlinear super-AKNS equations in the hierarchy by utilizing spectral parameter expansions. PACS: 02.30.Ik; 02.30.Jr; 02.20.Sv.

  13. Zero curvature representation, bi-Hamiltonian structure, and an integrable hierarchy for the Zakharov-Ito system

    Science.gov (United States)

    Baxter, Mathew; Choudhury, S. Roy; Van Gorder, Robert A.

    2015-06-01

    In the present paper, we present an integrable hierarchy for the Zakharov-Ito system. We first construct the Lenard recursion sequence and zero curvature representation for the Zakharov-Ito system, following Cao's method as significantly generalized by other authors. We then construct the bi-Hamiltonian structures employing variational trace identities but woven together with the Lenard recursion sequences. From this, we are in a position to construct an integrable hierarchy of equations from the Zakharov-Ito system, and we obtain the recursion operator and Poisson brackets for constructing this hierarchy. Finally, we demonstrate that the obtained hierarchy is indeed Liouville integrable.

  14. The Liouville integrable coupling system of the m-AKNS hierarchy and its Hamiltonian structure

    Institute of Scientific and Technical Information of China (English)

    Yue Chao; Yang Geng-Wen; Xu Yue-Cai

    2007-01-01

    In this paper a type of 9-dimensional vector loop algebra (F) is constructed,which is devoted to establish an isospectral problem.It follows that a Liouville integrable coupling system of the m-AKNS hierarchy is obtained by employing the Tu scheme,whose Hamiltonian structure is worked out by making use of constructed quadratic identity.The method given in the paper can be used to obtain many other integrable couplings and their Hamiltonian structures.

  15. A generalized super AKNS hierarchy associated with Lie superalgebra sl(2|1) and its super bi-Hamiltonian structure

    Science.gov (United States)

    Han, Jingwei; Yu, Jing

    2017-03-01

    Starting from a 3 × 3 matrix-valued spectral problem associated with a Lie superalgebra sl(2|1), a generalized super Ablowitz-Kaup-Newell-Segur (AKNS) hierarchy is derived. The resulting super AKNS hierarchy has a super bi-Hamiltonian structure by the supertrace identity.

  16. On flow structures and the hierarchy of shears

    Science.gov (United States)

    Dif-Pradalier, G.; Diamond, P. H.; McDevitt, C. J.; Sarazin, Y.; Grandgirard, V.; Garbet, X.; Chang, C. S.; Ku, S.

    2010-11-01

    We investigate the consequences of mean profile dynamics in flux-driven gyrokinetics. We report the emergence of a novel flow structure in plasma turbulence, which we call the ``ExB staircase.'' This structure connects to strong, standing corrugations in the plasma profiles, which is not related to rational q surfaces. We also show that the ExB shear associated to these mean profile corrugations is strongly dominant as compared to the usually-invoked zonal flow shear. Discussion of the dynamics of mean profiles (i) as another channel for turbulence regulation, missing in ``usual'' gyrokinetic approaches, (ii) its connection with turbulent stresses and the transport of potential vorticity, its link (iii) to the observed flow patterns and (iv) to the question of locality vs non-locality in transport is presented.

  17. Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.

    Science.gov (United States)

    Yamada, Takeshi; Abei, Masato; Danjoh, Inaho; Shirota, Ryoko; Yamashita, Taro; Hyodo, Ichinosuke; Nakamura, Yukio

    2015-04-11

    cells more effectively than the reverse sequence or either alone. We identified a unique HCC line, Li-7, which not only shows heterogeneity for a CD13(+) CSC hierarchy, but also undergoes a "population change" upon CSC differentiation. Sorafenib targeted the CSC in vitro, supporting the use of this model for screening drugs targeting the CSC. This type of "heterogeneous, unstable" cell line may prove more useful in the CSC era than conventional "homogeneous, stable" cell lines.

  18. Convectively Aggregated Structures Across a Hierarchy of Models

    Science.gov (United States)

    Silvers, Levi; Dipankar, Anurag; Hohenegger, Cathy

    2015-04-01

    Convective clouds are among the most interesting and poorest understood atmospheric phenomena. This study explores the interaction between deep convection and the lower troposphere with a focus on the coupling of deep convection to the lower tropospheric clouds, water vapor, and relative humidity. We are particularly interested in the controlling factors of the cloud amount and cloud size at cloud base across various model set-ups. In particular we seek to determine how the generation of large convective structures depends on the characteristics of the lower troposphere and parameterization choices. Our experiments are analyzed by comparing the mean state, the probability distribution functions of particular quantities, and snapshots in time of the spatial distribution of cloud related fields. It is shown that the formation of aggregated convective structures depends on the different model setups. Experiments performed using an NWP model (ICON-NWP) and two cloud-resolving models (ICON-LES and UCLA-LES) are compared. The ICOsahedral Nonhydrostatic (ICON) model is used to provide a unified modeling framework in which both the NWP and CRM versions use the same dynamical core but different physics packages. This allows for a fair comparison between the GCM and CRM and leads to a better understanding of both. To check the robustness of the CRM results we also compare the ICON experiments with the UCLA-LES model. The initial analysis looks at the ICON-NWP and both CRM experiments with a uniform domain size of (1800 km)2 and doubly periodic boundary conditions to determine some of the fundamental differences between the models. The NWP experiment has an effective resolution of 13.5 km while the CRM's have resolutions in the range of 5 km. We run the NWP experiments with the full suit of physics parameterizations as well as with the convection turned off. Further sensitivity studies are then made to isolate some of the key characteristics of the convection in each model

  19. Influence of Perceptual Saliency Hierarchy on Learning of Language Structures: An Artificial Language Learning Experiment.

    Science.gov (United States)

    Gong, Tao; Lam, Yau W; Shuai, Lan

    2016-01-01

    Psychological experiments have revealed that in normal visual perception of humans, color cues are more salient than shape cues, which are more salient than textural patterns. We carried out an artificial language learning experiment to study whether such perceptual saliency hierarchy (color > shape > texture) influences the learning of orders regulating adjectives of involved visual features in a manner either congruent (expressing a salient feature in a salient part of the form) or incongruent (expressing a salient feature in a less salient part of the form) with that hierarchy. Results showed that within a few rounds of learning participants could learn the compositional segments encoding the visual features and the order between them, generalize the learned knowledge to unseen instances with the same or different orders, and show learning biases for orders that are congruent with the perceptual saliency hierarchy. Although the learning performances for both the biased and unbiased orders became similar given more learning trials, our study confirms that this type of individual perceptual constraint could contribute to the structural configuration of language, and points out that such constraint, as well as other factors, could collectively affect the structural diversity in languages.

  20. Human infants' learning of social structures: the case of dominance hierarchy.

    Science.gov (United States)

    Mascaro, Olivier; Csibra, Gergely

    2014-01-01

    We tested 15-month-olds' capacity to represent social-dominance hierarchies with more than two agents. Our results showed that infants found it harder to memorize dominance relations that were presented in an order that hindered the incremental formation of a single structure (Study 1). These results suggest that infants attempt to build structures incrementally, relation by relation, thereby simplifying the complex problem of recognizing a social structure. Infants also found circular dominance structures harder to process than linear dominance structures (Study 2). These expectations about the shape of structures may facilitate learning. Our results suggest that infants attempt to represent social structures composed of social relations. They indicate that human infants go beyond learning about individual social partners and their respective relations and form hypotheses about how social groups are organized.

  1. Functional hierarchy of coronary circulation: direct evidence of a structure-function relation.

    Science.gov (United States)

    Kassab, Ghassan S

    2005-12-01

    The heart muscle is nourished by a complex system of blood vessels that make up the coronary circulation. Here we show that the design of the coronary circulation has a functional hierarchy. A full anatomic model of the coronary arterial tree, containing millions of blood vessels down to the capillary vessels, was simulated based on previously measured porcine morphometric data. A network analysis of blood flow through every vessel segment was carried out based on the laws of fluid mechanics and appropriate boundary conditions. Our results show an abrupt change in cross-sectional area that demarcates the transition from epicardial (EPCA) to intramyocardial (IMCA) coronary arteries. Furthermore, a similar pattern of blood flow was observed with a corresponding transition from EPCA to IMCA. These results suggest functional differences between the two types of vessels. An additional abrupt change occurs in the IMCA in relation to flow velocity. The velocity is fairly uniform proximal to these vessels but drops significantly distal to those vessels toward the capillary branches. This finding suggests functional differences between large and small IMCA. Collectively, these observations suggest a novel functional hierarchy of the coronary vascular tree and provide direct evidence of a structure-function relation.

  2. Understanding `galaxy groups' as a unique structure in the universe

    Science.gov (United States)

    Paul, S.; John, R. S.; Gupta, P.; Kumar, H.

    2017-10-01

    'Galaxy groups' have hardly been realized as a separate class of objects with specific characteristics in the structural hierarchy. The presumption that the self-similarity of dark matter structures is a valid prescription for the baryonic universe at all scales has rendered smaller structures undetectable by current observational facilities, leading to lesser dedicated studies on them. Some recent reports that indicate a deviation from LX-T scaling in groups compared to clusters have motivated us to study their physical properties in depth. In this article, we report the extensive study on physical properties of groups in comparison to the clusters through cosmological hydrodynamic plus N-body simulations using enzo 2.2 code. As additional physics, radiative cooling, heating due to supernova and star motions, star formation and stellar feedback have been implemented. We have produced a mock sample of 362 objects with mass ranging from 5 × 1012 M⊙ to 2.5 × 1015 M⊙. Strikingly, we have found that objects with mass below ∼8 × 1013 M⊙ do not follow any of the cluster self-similar laws in hydrostatics, not even in thermal and non-thermal energies. Two distinct scaling laws are observed to be followed with breaks at ∼8 × 1013 M⊙ for mass, ∼1 keV for temperature and ∼1 Mpc for radius. This places groups as a distinct entity in the hierarchical structures, well demarcated from clusters. This study reveals that groups are mostly far away from virialization, suggesting the need for formulating new models for deciphering their physical parameters. They are also shown to have high turbulence and more non-thermal energy stored, indicating better visibility in the non-thermal regime.

  3. Exploring the significance of structural hierarchy in material systems-A review

    Science.gov (United States)

    Pan, Ning

    2014-06-01

    Structural hierarchy and heterogeneity are inherent features in biological materials, but their significance in affecting the system behaviors is yet to be fully understood. In Sec. I, this article first identifies the major characteristics that manifest, or are resulted from, such hierarchy and heterogeneity in materials. Then in Sec. II, it presents several typical natural material systems including wood, bone, and others from animals to illustrate the proposed views. The paper also discusses a man-made smart material, textiles, to demonstrate that textiles are hierarchal, multifunctional, highly complex, and arguably the engineered material closest on a par with biological materials in complexity, and, more importantly, we can still learn quite a few new things from them in development of novel materials. In Sec. III, the paper summarizes several general approaches in developing a hierarchal material system at various scales, including structure thinning and splitting, laminating and layering, spatial and angular orientation, heterogenization and hybridization, and analyzes the advantages associated with them. It also stresses the adverse consequences once the existing structural hierarchy breaks down due to various mutations in biological systems. It discusses, in particular, the influences of moisture and air on material properties, given the near ubiquitousness of both air and water in materials. It next deals with in Sec. IV, some theoretical issues in material research including packing and ordering, the bi-modular mechanics, the behavior non-affinities due to disparity in hierarchal levels, the importance of system dimensionality in a hierarchal material system, and more philosophically, the issues of Nature's wisdom versus Intelligent Design. Section V then offers some concluding remarks, including a recap of the major issues covered in this article, and some general conclusions derived from the analyses and discussions. The main purpose of this paper is

  4. IT vendor selection model by using structural equation model & analytical hierarchy process

    Science.gov (United States)

    Maitra, Sarit; Dominic, P. D. D.

    2012-11-01

    Selecting and evaluating the right vendors is imperative for an organization's global marketplace competitiveness. Improper selection and evaluation of potential vendors can dwarf an organization's supply chain performance. Numerous studies have demonstrated that firms consider multiple criteria when selecting key vendors. This research intends to develop a new hybrid model for vendor selection process with better decision making. The new proposed model provides a suitable tool for assisting decision makers and managers to make the right decisions and select the most suitable vendor. This paper proposes a Hybrid model based on Structural Equation Model (SEM) and Analytical Hierarchy Process (AHP) for long-term strategic vendor selection problems. The five steps framework of the model has been designed after the thorough literature study. The proposed hybrid model will be applied using a real life case study to assess its effectiveness. In addition, What-if analysis technique will be used for model validation purpose.

  5. Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex

    Energy Technology Data Exchange (ETDEWEB)

    Seok, Seung-Hyeon; Lee, Woojong; Jiang, Li; Molugu, Kaivalya; Zheng, Aiping; Li, Yitong; Park, Sanghyun; Bradfield, Christopher A.; Xing, Yongna (UW)

    2017-04-10

    he aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and mediates broad responses to numerous environmental pollutants and cellular metabolites, modulating diverse biological processes from adaptive metabolism, acute toxicity, to normal physiology of vascular and immune systems. The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin response element (DRE) in the promoter of downstream genes. We determined the crystal structure of the mammalian AHR–ARNT heterodimer in complex with the DRE, in which ARNT curls around AHR into a highly intertwined asymmetric architecture, with extensive heterodimerization interfaces and AHR interdomain interactions. Specific recognition of the DRE is determined locally by the DNA-binding residues, which discriminates it from the closely related hypoxia response element (HRE), and is globally affected by the dimerization interfaces and interdomain interactions. Changes at the interdomain interactions caused either AHR constitutive nuclear localization or failure to translocate to nucleus, underlying an allosteric structural pathway for mediating ligand-induced exposure of nuclear localization signal. These observations, together with the global higher flexibility of the AHR PAS-A and its loosely packed structural elements, suggest a dynamic structural hierarchy for complex scenarios of AHR activation induced by its diverse ligands.

  6. Constructing Black Titania with Unique Nanocage Structure for Solar Desalination.

    Science.gov (United States)

    Zhu, Guilian; Xu, Jijian; Zhao, Wenli; Huang, Fuqiang

    2016-11-23

    Solar desalination driven by solar radiation as heat source is freely available, however, hindered by low efficiency. Herein, we first design and synthesize black titania with a unique nanocage structure simultaneously with light trapping effect to enhance light harvesting, well-crystallized interconnected nanograins to accelerate the heat transfer from titania to water and with opening mesopores (4-10 nm) to facilitate the permeation of water vapor. Furthermore, the coated self-floating black titania nanocages film localizes the temperature increase at the water-air interface rather than uniformly heating the bulk of the water, which ultimately results in a solar-thermal conversion efficiency as high as 70.9% under a simulated solar light with an intensity of 1 kW m(-2) (1 sun). This finding should inspire new black materials with rationally designed structure for superior solar desalination performance.

  7. Structured Numbers. Properties of a hierarchy of internal operations in binary tress.

    OpenAIRE

    Blondel, Vincent

    1998-01-01

    We introduce a hierarchy of operations on (finite and infinite) binary trees. The operations are obtained by successive repetition of one initial operation. The first three operations are generalizations of the operations of addition, multiplication and exponentiation for positive integers.

  8. Intergroup Consensus/Disagreement in Support of Group-Based Hierarchy: An Examination of Socio-Structural and Psycho-Cultural Factors

    Science.gov (United States)

    Lee, I-Ching; Pratto, Felicia; Johnson, Blair T.

    2011-01-01

    A meta-analysis examined the extent to which socio-structural and psycho-cultural characteristics of societies correspond with how much gender and ethnic/racial groups differ on their support of group-based hierarchy. Robustly, women opposed group-based hierarchy more than men did, and members of lower power ethnic/racial groups opposed…

  9. Structural and Functional Hierarchy in Photosynthetic Energy Conversion—from Molecules to Nanostructures

    Science.gov (United States)

    Szabó, Tibor; Magyar, Melinda; Hajdu, Kata; Dorogi, Márta; Nyerki, Emil; Tóth, Tünde; Lingvay, Mónika; Garab, Győző; Hernádi, Klára; Nagy, László

    2015-12-01

    Basic principles of structural and functional requirements of photosynthetic energy conversion in hierarchically organized machineries are reviewed. Blueprints of photosynthesis, the energetic basis of virtually all life on Earth, can serve the basis for constructing artificial light energy-converting molecular devices. In photosynthetic organisms, the conversion of light energy into chemical energy takes places in highly organized fine-tunable systems with structural and functional hierarchy. The incident photons are absorbed by light-harvesting complexes, which funnel the excitation energy into reaction centre (RC) protein complexes containing redox-active chlorophyll molecules; the primary charge separations in the RCs are followed by vectorial transport of charges (electrons and protons) in the photosynthetic membrane. RCs possess properties that make their use in solar energy-converting and integrated optoelectronic systems feasible. Therefore, there is a large interest in many laboratories and in the industry toward their use in molecular devices. RCs have been bound to different carrier matrices, with their photophysical and photochemical activities largely retained in the nano-systems and with electronic connection to conducting surfaces. We show examples of RCs bound to carbon-based materials (functionalized and non-functionalized single- and multiwalled carbon nanotubes), transitional metal oxides (ITO) and conducting polymers and porous silicon and characterize their photochemical activities. Recently, we adapted several physical and chemical methods for binding RCs to different nanomaterials. It is generally found that the P+(QAQB)- charge pair, which is formed after single saturating light excitation is stabilized after the attachment of the RCs to the nanostructures, which is followed by slow reorganization of the protein structure. Measuring the electric conductivity in a direct contact mode or in electrochemical cell indicates that there is an

  10. Growth Mechanism of a Unique Hierarchical Vaterite Structure

    Science.gov (United States)

    Ma, Guobin; Xu, Yifei; Wang, Mu

    2013-03-01

    Calcium carbonate is one of the most significant minerals in nature as well as in biogenic sources. Calcium carbonate occurs naturally in three crystalline polymorphs, i.e., calcite, aragonite, and vaterite. Although it has been attracted much research attention to understanding of the formation mechanisms of the material, the properties of the vaterite polymorph is not well known. Here we report synthesis and formation mechanism of a unique hierarchical structure of vaterite. The material is grown by a controlled diffusion method. The structure possesses a core and an outer part. The core is convex lens-like and is formed by vaterite nanocrystals that have small misorientations. The outer part is separated into six garlic clove-like segments. Each segment possesses piles of plate-like vaterite crystals, and the orientations of the plates continuously change from pile to pile. Based on real-time experimental results and the structural analysis, a growth mechanism is presented. Work supported by NSFC (Grant No. 51172104) and MOST of China (Grant No. 2101CB630705)

  11. Why hierarchies thrive.

    Science.gov (United States)

    Leavitt, Harold J

    2003-03-01

    Hardly anyone has a good word to say about hierarchies. Academics, consultants, and management gurus regularly forecast their imminent replacement because hierarchies--even when populated by considerate and intelligent people--can be cruel and stupid. They routinely transform motivated and loyal employees into disaffected Dilberts. It's no wonder that we continue to search for more humane and productive alternatives to them. Yet the intensity with which we struggle against hierarchies only serves to highlight their durability. Hierarchy, it seems, may be intrinsic not only to the natural world but also to our own natures. In this article, organizational behavior expert Harold J. Leavitt presents neither a defense of human hierarchies nor another attack on them. Instead, he offers a reality check, a reminder that hierarchy remains the basic structure of most, if not all, large, ongoing human organizations. That's because although they are often depicted as being out of date, hierarchies have proved to be extraordinarily adaptive. Over the past 50 years, for example, they have co-opted the three major managerial movements--human relations, analytic management, and communities of practice. Hierarchies also persist because they deliver real practical and psychological value, and they fulfill our deep need for order and security. Despite the good they may do, hierarchies are inevitably authoritarian. That authoritarianism shows up in all kinds of ways and influences everything in organizations, particularly communication. In multilevel organizations, for instance, messages get distorted as they travel up and down the ladder of command. Self-protection and self-interest weigh in, and relevant information is lost as messages make stops along the route. Sensitive leaders take steps to make speaking the truth as painless as possible. But it never is in organizations, because authoritarianism is an immutable element of hierarchy.

  12. Super-Affine Hierarchies and their Poisson Embeddings

    CERN Document Server

    Toppan, F

    1998-01-01

    The link between (super)-affine Lie algebras as Poisson brackets structures and integrable hierarchies provides both a classification and a tool for obtaining superintegrable hierarchies. The lack of a fully systematic procedure for constructing matrix-type Lax operators, which makes the supersymmetric case essentially different from the bosonic counterpart, is overcome via the notion of Poisson embeddings (P.E.), i.e. Poisson mappings relating affine structures to conformal structures (in their simplest version P.E. coincide with the Sugawara construction). A full class of hierarchies can be recovered by using uniquely Lie-algebraic notions. The group-algebraic properties implicit in the super-affine picture allow a systematic derivation of reduced hierarchies by imposing either coset conditions or hamiltonian constraints (or possibly both).

  13. Unique Structural Features of Influenza Virus H15 Hemagglutinin

    Energy Technology Data Exchange (ETDEWEB)

    Tzarum, Netanel; McBride, Ryan; Nycholat, Corwin M.; Peng, Wenjie; Paulson, James C.; Wilson, Ian A. (Scripps)

    2017-04-12

    Influenza A H15 viruses are members of a subgroup (H7-H10-H15) of group 2 hemagglutinin (HA) subtypes that include H7N9 and H10N8 viruses that were isolated from humans during 2013. The isolation of avian H15 viruses is, however, quite rare and, until recently, geographically restricted to wild shorebirds and waterfowl in Australia. The HAs of H15 viruses contain an insertion in the 150-loop (loop beginning at position 150) of the receptor-binding site common to this subgroup and a unique insertion in the 260-loop compared to any other subtype. Here, we show that the H15 HA has a high preference for avian receptor analogs by glycan array analyses. The H15 HA crystal structure reveals that it is structurally closest to H7N9 HA, but the head domain of the H15 trimer is wider than all other HAs due to a tilt and opening of the HA1 subunits of the head domain. The extended 150-loop of the H15 HA retains the conserved conformation as in H7 and H10 HAs. Furthermore, the elongated 260-loop increases the exposed HA surface and can contribute to antigenic variation in H15 HAs. Since avian-origin H15 HA viruses have been shown to cause enhanced disease in mammalian models, further characterization and immune surveillance of H15 viruses are warranted.

    IMPORTANCEIn the last 2 decades, an apparent increase has been reported for cases of human infection by emerging avian influenza A virus subtypes, including H7N9 and H10N8 viruses isolated during 2013. H15 is the other member of the subgroup of influenza A virus group 2 hemagglutinins (HAs) that also include H7 and H10. H15 viruses have been restricted to Australia, but recent isolation of H15 viruses in western Siberia suggests that they could be spread more globally via the avian flyways that converge and emanate from this region. Here we report on characterization of the three-dimensional structure and receptor specificity of the H15 hemagglutinin, revealing distinct features and specificities that can

  14. A structure-based software reliability allocation using fuzzy analytic hierarchy process

    Science.gov (United States)

    Chatterjee, Subhashis; Singh, Jeetendra B.; Roy, Arunava

    2015-02-01

    During the design phase of a software, it is often required to evaluate the reliability of the software system. At this stage of development, one crucial question arises 'how to achieve a target reliability of the software?' Reliability allocation methods can be used to set reliability goals for individual components. In this paper, a software reliability allocation model has been proposed incorporating the user view point about various functions of a software. Proposed reliability allocation method attempts to answer the question 'how reliable should the system components be?' The proposed model will be useful for determining the reliability goal at the planning and design phase of a software project, hence making reliability a singular measure for performance evaluation. Proposed model requires a systematic formulation of user requirements and preference into the technical design and reliability of the software. To accomplish this task, a system hierarchy has been established, which combines the user's view of the system with that of the software manager and the programmer. Fuzzy analytic hierarchy process (FAHP) has been used to derive the required model parameters from the hierarchy. Sensitivity analysis has also been carried out in this paper. Finally, an example has been given to illustrate the effectiveness and feasibility of the proposed method.

  15. Nonlinear Integrable Couplings of Levi Hierarchy and WKI Hierarchy

    Directory of Open Access Journals (Sweden)

    Zhengduo Shan

    2014-01-01

    Full Text Available With the help of the known Lie algebra, a type of new 8-dimensional matrix Lie algebra is constructed in the paper. By using the 8-dimensional matrix Lie algebra, the nonlinear integrable couplings of the Levi hierarchy and the Wadati-Konno-Ichikawa (WKI hierarchy are worked out, which are different from the linear integrable couplings. Based on the variational identity, the Hamiltonian structures of the above hierarchies are derived.

  16. Nonlinear Integrable Couplings of Levi Hierarchy and WKI Hierarchy

    OpenAIRE

    Zhengduo Shan; Hongwei Yang; Baoshu Yin

    2014-01-01

    With the help of the known Lie algebra, a type of new 8-dimensional matrix Lie algebra is constructed in the paper. By using the 8-dimensional matrix Lie algebra, the nonlinear integrable couplings of the Levi hierarchy and the Wadati-Konno-Ichikawa (WKI) hierarchy are worked out, which are different from the linear integrable couplings. Based on the variational identity, the Hamiltonian structures of the above hierarchies are derived.

  17. Structure-function hierarchies and von Kármán-Howarth relations for turbulence in magnetohydrodynamical equations

    Science.gov (United States)

    Basu, Abhik; Naji, Ali; Pandit, Rahul

    2014-01-01

    We generalize the method of A. M. Polyakov, [Phys. Rev. E 52, 6183 (1995), 10.1103/PhysRevE.52.6183] for obtaining structure-function relations in turbulence in the stochastically forced Burgers equation, to develop structure-function hierarchies for turbulence in three models for magnetohydrodynamics (MHD). These are the Burgers analogs of MHD in one dimension [Eur. Phys. J. B 9, 725 (1999), 10.1007/s100510050817], and in three dimensions (3DMHD and 3D Hall MHD). Our study provides a convenient and unified scheme for the development of structure-function hierarchies for turbulence in a variety of coupled hydrodynamical equations. For turbulence in the three sets of MHD equations mentioned above, we obtain exact relations for third-order structure functions and their derivatives; these expressions are the analogs of the von Kármán-Howarth relations for fluid turbulence. We compare our work with earlier studies of such relations in 3DMHD and 3D Hall MHD.

  18. A Soliton Hierarchy Associated with a Spectral Problem of 2nd Degree in a Spectral Parameter and Its Bi-Hamiltonian Structure

    Directory of Open Access Journals (Sweden)

    Yuqin Yao

    2016-01-01

    Full Text Available Associated with so~(3,R, a new matrix spectral problem of 2nd degree in a spectral parameter is proposed and its corresponding soliton hierarchy is generated within the zero curvature formulation. Bi-Hamiltonian structures of the presented soliton hierarchy are furnished by using the trace identity, and thus, all presented equations possess infinitely commuting many symmetries and conservation laws, which implies their Liouville integrability.

  19. On the analytic hierarchy process and decision support based on fuzzy-linguistic preference structures

    DEFF Research Database (Denmark)

    Franco de los Rios, Camilo Andres

    2014-01-01

    The Analytic Hierarchy Process (AHP) has received different fuzzy formulations, where two main lines of research can be identified in literature. The most popular one refers to the Extent Analysis Method, which has been subject of recent criticism, among other things, due to a number......, where experts value pairs of alternatives/criteria with words, making it essentially fuzzy under the view that words can be represented by fuzzy sets for their respective computation. Hence, reasoning with fuzzy logic is justified by the analytical framework that it offers to design the meaning of words...

  20. Participatory hierarchies

    DEFF Research Database (Denmark)

    Kristiansen, Marianne; Bloch-Poulsen, Jørgen

    2016-01-01

    is to show that a participatory approach can unintentionally create new hierarchies or reinforce existing ones, thus leading to the exclusion of certain employees (or action researchers) in terms of voice and/or choice. Second, the theoretical purpose is to show how participation in OAR projects can......This article focuses on employee participation in organisational action research (OAR), presenting three examples of OAR in one private and two public organisations in Denmark, respectively. Each of these examples shows how participatory hierarchies between employees and between them and action...... researchers are constructed in OAR projects, leading in these cases to the exclusion of silent pedagogues, elderly foremen, and a critical employee. Based on these examples, the article has three mutually connected purposes, an empirical, theoretical, and methodological purpose. First, the empirical purpose...

  1. Social structure in a family group of Guanaco (Lama guanicoe, Ungulate): is female hierarchy based on 'prior attributes' or 'social dynamics'?

    Science.gov (United States)

    Correa, Loreto A; Zapata, Beatriz; Samaniego, Horacio; Soto-Gamboa, Mauricio

    2013-09-01

    Social life involves costs and benefits mostly associated with how individuals interact with each other. The formation of hierarchies inside social groups has evolved as a common strategy to avoid high costs stemming from social interactions. Hierarchical relationships seem to be associated with different features such as body size, body condition and/or age, which determine dominance ability ('prior attributes' hypothesis). In contrast, the 'social dynamic' hypothesis suggests that an initial social context is a determinant in the formation of the hierarchy, more so than specific individual attributes. Hierarchical rank places individuals in higher positions, which presumably increases resource accessibility to their benefit, including opportunities for reproduction. We evaluate the maintenance of hierarchy in a family group of guanacos (Lama guanicoe) and evaluate the possible mechanisms involved in the stability of these interactions and their consequences. We estimate the linearity of social hierarchy and their dynamics. We find evidence of the formation of a highly linear hierarchy among females with males positioned at the bottom of the hierarchy. This hierarchy is not affected by physical characteristics or age, suggesting that it is established only through intra-group interactions. Rank is not related with calves' weight gain either; however, subordinated females, with lower rank, exhibit higher rates of allosuckling. We found no evidence of hierarchical structure in calves suggesting that hierarchical relationship in guanacos could be established during the formation of the family group. Hence, our results suggest that hierarchical dynamics could be related more to social dynamics than to prior attributes. We finally discuss the importance of hierarchies established by dominance and their role in minimizing social costs of interactions. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Structure Matters: The Role of Clique Hierarchy in the Relationship Between Adolescent Social Status and Aggression and Prosociality.

    Science.gov (United States)

    Pattiselanno, Kim; Dijkstra, Jan Kornelis; Steglich, Christian; Vollebergh, Wilma; Veenstra, René

    2015-12-01

    Peer cliques form an important context for the social development of adolescents. Although clique members are often similar in social status, also within cliques, status differences exist. How differences in social status between clique members are related to behaviors of its individual members is rather unknown. This study examined to what extent the relationship of individual social status (i.e., perceived popularity) with aggression and prosocial behavior depends on the level of internal clique hierarchy. The sample consists of 2674 adolescents (49.8% boys), with a mean age of 14.02. We focused specifically on physical and relational aggression, and practical and emotional support, because these behaviors have shown to be of great importance for social relationships and social standing among adolescents. The internal status hierarchy of cliques was based on the variation in individual social status between clique members (i.e., clique hierarchization) and the structure of status scores within a clique (pyramid shape, inverted pyramid, or equal distribution of social status scores) (i.e., clique status structure). The results showed that differences in aggressive and prosocial behaviors were particularly moderated by clique status structure: aggression was stronger related to individual social status in (girls') cliques where the clique status structure reflected an inverted pyramid with relatively more high status adolescents within the clique than low status peers, and prosocial behavior showed a significant relationship with individual social status, again predominantly in inverted pyramid structured (boys' and girls') cliques. Furthermore, these effects differed by types of gender cliques: the associations were found in same gender but not mixed-gender cliques. The findings stress the importance of taking into account internal clique characteristics when studying adolescent social status in relationship to aggression and prosociality.

  3. Delegation Within Hierarchies

    DEFF Research Database (Denmark)

    Dobrajska, Magdalena; Billinger, Stephan; Karim, Samina

    2015-01-01

    We investigate trade-offs associated with delegating authority over multiple interrelated decisions in a complex task structure. The empirical setting is a business process of a global Fortune 50 firm. The firm decentralized its organization and redefined decision authority across organizational......-relevant knowledge, the matching of required knowledge and managers’ expertise, and information processing intensity affect (a) the occurrence of delegation and, (b) if delegation occurs, how far down the organizational hierarchy authority is delegated. We discuss how these findings complement existing theories...... hierarchies between 2008 and 2011. We employ regression analysis of microlevel data on the allocation of decision authority between formal and real authority, and further on the organization design of 761 decision tasks within a hierarchy. Our findings show how the specialization of decision...

  4. Homodiselenacalix[4]arenes: Molecules with Unique Channelled Crystal Structures.

    Science.gov (United States)

    Thomas, Joice; Dobrzańska, Liliana; Van Meervelt, Luc; Quevedo, Mario Alfredo; Woźniak, Krzysztof; Stachowicz, Marcin; Smet, Mario; Maes, Wouter; Dehaen, Wim

    2016-01-18

    A synthetic route towards homodiselenacalix[4]arene macrocycles is presented, based on the dynamic covalent chemistry of diselenides. The calixarene inner rim is decorated with either alkoxy or tert-butyl ester groups. Single-crystal X-ray analysis of two THF solvates with methoxy and ethoxy substituents reveals the high similarity of their molecular structures and alterations on the supramolecular level. In both crystal structures, solvent channels are present and differ in both shape and capacity. Furthermore, the methoxy-substituted macrocycle undergoes a single-crystal-to-single-crystal transformation during which the molecular structure changes its conformation from 1,3-alternate (loaded with THF/water) to 1,2-alternate (apohost form). Molecular modelling techniques were applied to explore the conformational and energetic behaviour of the macrocycles.

  5. Gelled Complex Fluids: Combining Unique Structures with Mechanical Stability.

    Science.gov (United States)

    Stubenrauch, Cosima; Gießelmann, Frank

    2016-03-01

    Gelled complex fluids are soft materials in which the microstructure of the complex fluid is combined with the mechanical stability of a gel. To obtain a gelled complex fluid one either adds a gelator to a complex fluid or replaces the solvent in a gel by a complex fluid. The most prominent example of a "natural" gelled complex fluid is the cell. There are various strategies by which one can form a gelled complex fluid; one such strategy is orthogonal self-assembly, that is, the independent but simultaneous formation of two coexisting self-assembled structures within one system. The aim of this Review is to describe the structure and potential applications of various man-made gelled complex fluids and to clarify whether or not the respective system is formed by orthogonal self-assembly.

  6. Generalized W-algebras and integrable hierarchies

    CERN Document Server

    Burroughs, N J; Hollowood, Timothy J; Miramontes, J L

    1992-01-01

    We report on generalizations of the KdV-type integrable hierarchies of Drinfel'd and Sokolov. These hierarchies lead to the existence of new classical $W$-algebras, which arise as the second Hamiltonian structure of the hierarchies. In particular, we present a construction of the $W_n^{(l)}$ algebras.

  7. Ansatz for dynamical hierarchies

    DEFF Research Database (Denmark)

    Rasmussen, S.; Baas, N.A.; Mayer, B.

    2001-01-01

    Complex, robust functionalities can be generated naturally in at least two ways: by the assembly of structures and by the evolution of structures. This work is concerned with spontaneous formation of structures. We define the notion of dynamical hierarchies in natural systems and show...... the importance of this particular kind of organization for living systems. We then define a framework that enables us to formulate, investigate, and manipulate such dynamical hierarchies. This framework allows us to simultaneously investigate different levels of description together with them interrelationship...... three. Formulating this system as a simple two-dimensional molecular dynamics (MD) lattice gas allows us within one dynamical system to demonstrate the successive emergence of two higher levels (three levels all together) of robust structures with associated properties. Second, we demonstrate how...

  8. Electrospun superhydrophobic membranes with unique structures for membrane distillation.

    Science.gov (United States)

    Liao, Yuan; Loh, Chun-Heng; Wang, Rong; Fane, Anthony G

    2014-09-24

    With modest temperature demand, low operating pressure, and high solute rejection, membrane distillation (MD) is an attractive option for desalination, waste treatment, and food and pharmaceutical processing. However, large-scale practical applications of MD are still hindered by the absence of effective membranes with high hydrophobicity, high porosity, and adequate mechanical strength, which are important properties for MD permeation fluxes, stable long-term performance, and effective packing in modules without damage. This study describes novel design strategies for highly robust superhydrophobic dual-layer membranes for MD via electrospinning. One of the newly developed membranes comprises a durable and ultrathin 3-dimensional (3D) superhydrophobic skin and porous nanofibrous support whereas another was fabricated by electrospinning 3D superhydrophobic layers on a nonwoven support. These membranes exhibit superhydrophobicity toward distilled water, salty water, oil-in-water emulsion, and beverages, which enables them to be used not only for desalination but also for other processes. The superhydrophobic dual-layer membrane #3S-N with nanofibrous support has a competitive permeation flux of 24.6 ± 1.2 kg m(-2) h(-1) in MD (feed and permeate temperate were set as 333 and 293 K, respectively) due to the higher porosity of the nanofibrous scaffold. Meanwhile, the membranes with the nonwoven support exhibit greater mechanical strength due to this support combined with better long-term performance because of the thicker 3D superhydrophobic layers. The morphology, pore size, porosity, mechanical properties, and liquid enter pressure of water of these superhydrophobic composite membranes with two different structures are reported and compared with commercial polyvinylidene fluoride membranes.

  9. Dispersionless noncommutative Kadomtsev Petviashvili hierarchy: Multi-Hamiltonian structure and large N-like V-algebras

    Science.gov (United States)

    Wang, Ning; Zhang, Xiao Wen

    2006-07-01

    We propose a dispersionless limit of the NC Kadomtsev Petviashvili hierarchy. Multi-Hamiltonian formulation, l-reductions and relevant W-algebras are investigated. As examples, Gelfand Dickey (GD) Poisson brackets for dispersionless NCKdV and NC Boussinesq hierarchies are constructed explicitly. The associated GD Poisson algebras are shown large N-like analogs of classical V-algebras.

  10. Existence and Uniqueness of Endemic States for the Age-structured MSEIR Epidemic Model

    Institute of Scientific and Technical Information of China (English)

    Xue-zhi Li; Geni Gupur; Guang-tian Zhu

    2002-01-01

    The existence and uniqueness of positive steady states for the age-structured MSEIR epidemic model with age-dependent transmission coefficient is considered. Threshold results for the existence of endemic states are established; under certain conditions, uniqueness is also shown.

  11. ELEMENTS OF CONTROL OVER HIERARCHIE SYSTEMS WITH ASSUMED HIERARCHY

    Directory of Open Access Journals (Sweden)

    Kushnir N. V.

    2015-05-01

    Full Text Available The article presents a mathematical model of control over dynamic hierarchy system. The model was proposed for dealing with systems with assumed order in the technical problem of predicting destructions depending onto the amount of defects on different scale levels. The problem of the closest to a certain point of shelf life of hierarchy system is solved. The example of approach control during the given time is given. The problem concerns mathematic programming. Formulation of multi-parameter vector optimization criteria (improvement with its own hierarchy and the formal exercise of multi-criteria optimization of the model parameters. The research can achieve clarity about the conditions under which the structure is preserved. Managing sustainable development system with a given level of the hierarchy for the technical systems can only be achieved in keeping

  12. The Monge-Ampère equation: Hamiltonian and symplectic structures, recursions, and hierarchies

    NARCIS (Netherlands)

    Kersten, P.H.M.; Krasil'shchik, I.; Verbovetsky, A.V.

    2004-01-01

    Using methods of geometry and cohomology developed recently, we study the Monge-Ampère equation, arising as the first nontrivial equation in the associativity equations, or WDVV equations. We describe Hamiltonian and symplectic structures as well as recursion operators for this equation in its

  13. A Novel Environmental Performance Evaluation of Thailand’s Food Industry Using Structural Equation Modeling and Fuzzy Analytic Hierarchy Techniques

    Directory of Open Access Journals (Sweden)

    Anirut Pipatprapa

    2016-03-01

    Full Text Available Currently, the environment and sustainability are important topics for every industry. The food industry is particularly complicated in this regard because of the dynamic and complex character of food products and their production. This study uses structural equation modeling (SEM and a fuzzy analytic hierarchy process (FAHP to investigate which factors are suitable for evaluating the environmental performance of Thailand’s food industry. A first-stage questionnaire survey was conducted with 178 managers in the food industry that obtained a certificate from the Department of Industrial Work of Thailand to synthesize the performance measurement model and the significance of the relationship between the indicators. A second-stage questionnaire measured 18 experts’ priorities regarding the criteria and sub-factors involved in the different aspects and assessment items regarding environmental performance. SEM showed that quality management, market orientation, and innovation capability have a significantly positive effect on environmental performance. The FAHP showed that the experts were most concerned about quality management, followed by market orientation and innovation capability; the assessment items for quality policy, quality assurance, and customer orientation were of the most concern. The findings of this study can be referenced and support managerial decision making when monitoring environmental performance.

  14. Intergroup consensus/disagreement in support of group-based hierarchy: an examination of socio-structural and psycho-cultural factors.

    Science.gov (United States)

    Lee, I-Ching; Pratto, Felicia; Johnson, Blair T

    2011-11-01

    A meta-analysis examined the extent to which socio-structural and psycho-cultural characteristics of societies correspond with how much gender and ethnic/racial groups differ on their support of group-based hierarchy. Robustly, women opposed group-based hierarchy more than men did, and members of lower power ethnic/racial groups opposed group-based hierarchy more than members of higher power ethnic/racial groups did. As predicted by social dominance theory, gender differences were larger, more stable, and less variable from sample to sample than differences between ethnic/racial groups. Subordinate gender and ethnic/racial group members disagreed more with dominants in their views of group-based hierarchy in societies that can be considered more liberal and modern (e.g., emphasizing individualism and change from traditions), as well as in societies that enjoyed greater gender equality. The relations between gender and ethnic/racial groups are discussed, and implications are developed for social dominance theory, social role theory, biosocial theory, social identity theory, system justification theory, realistic group conflict theory, and relative deprivation theory. (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  15. Intergroup Consensus/Disagreement in Support of Group Based Hierarchy: An Examination of Socio-Structural and Psycho-Cultural Factors

    Science.gov (United States)

    Lee, I-Ching; Pratto, Felicia; Johnson, Blair T.

    2011-01-01

    A meta-analysis examined the extent to which socio-structural and psycho-cultural characteristics of societies correspond with how much gender and ethnic/racial groups differ on their support of group-based hierarchy. Robustly, women opposed group-based hierarchy more than men did and members of lower-power ethnic/racial groups opposed group-based hierarchy more than members of higher-power ethnic/racial groups. As predicted by social dominance theory, gender differences were larger, more stable, and less variable from sample to sample than differences between ethnic/racial groups. Subordinate gender and ethnic/racial group members disagreed more with dominants in their views of group-based hierarchy in societies that can be considered more liberal and modern (e.g., emphasizing individualism and change from traditions), as well as in societies that enjoyed greater gender equality. The relations between gender and ethnic/racial groups are discussed and implications are developed for social dominance theory, social role theory and biosocial theory, social identity theory, system justification theory, realistic group conflict theory and relative deprivation theory. PMID:22023142

  16. Higher-Order Hierarchies

    DEFF Research Database (Denmark)

    Ernst, Erik

    2003-01-01

    . Finally, it must be possible to write generic code that works on every hierarchy derived from the hierarchy for which it was written. This paper presents a language design that supports such a notion of higher-order hierarchies. It has been implemented in context of a full-fledged, statically typed...... be possible to create hierarchies incrementally based on existing hierarchies, such that commonalities are expressed via reuse, not duplication. Second, the hierarchies must themselves be organized into hierarchies, such that their relationships are made explicit and can be exploited in a type safe manner...... language....

  17. Generic uniqueness of a structured matrix factorization and applications in blind source separation

    OpenAIRE

    Domanov, Ignat; De Lathauwer, Lieven

    2016-01-01

    Algebraic geometry, although little explored in signal processing, provides tools that are very convenient for investigating generic properties in a wide range of applications. Generic properties are properties that hold "almost everywhere". We present a set of conditions that are sufficient for demonstrating the generic uniqueness of a certain structured matrix factorization. This set of conditions may be used as a checklist for generic uniqueness in different settings. We discuss two partic...

  18. Theoretical Thermochemistry for Organic Molecules: Development of the Generalized Connectivity-Based Hierarchy.

    Science.gov (United States)

    Ramabhadran, Raghunath O; Raghavachari, Krishnan

    2011-07-12

    A generalized, unique thermochemical hierarchy applicable for all closed shell organic molecules is developed in this paper. In this chemically intuitive, structure-based approach, the connectivity of the atoms in an organic molecule is used to construct our hierarchy called "connectivity-based hierarchy" (CBH). The hierarchy has several rungs and ascending up the hierarchy increasingly balances the reaction energy. It requires no prior knowledge of the types of molecules and hybridizations for the appropriate balancing of the bond types and the bonding environments of the atoms. The rungs can be generated by an automated computer program for any closed shell organic molecule, and the first three rungs generate the simplest reactions for the widely used isodesmic, hypohomodesmotic, and hyperhomodesmotic schemes. The generated reaction schemes are unique for each rung and are derived in a simpler manner than previous approaches, avoiding potential errors. This work also suggests that for closed shell organic molecules, the previously well-studied homodesmotic scheme does not have a fundamental structure-based origin. In a preliminary application of CBH, density functional theory has been used to calculate accurate enthalpies of formation for a test set of 20 organic molecules. The performance of the hierarchy suggests that it will be useful to predict accurate thermodynamic properties of larger organic molecules.

  19. Generic Uniqueness of a Structured Matrix Factorization and Applications in Blind Source Separation

    Science.gov (United States)

    Domanov, Ignat; Lathauwer, Lieven De

    2016-06-01

    Algebraic geometry, although little explored in signal processing, provides tools that are very convenient for investigating generic properties in a wide range of applications. Generic properties are properties that hold "almost everywhere". We present a set of conditions that are sufficient for demonstrating the generic uniqueness of a certain structured matrix factorization. This set of conditions may be used as a checklist for generic uniqueness in different settings. We discuss two particular applications in detail. We provide a relaxed generic uniqueness condition for joint matrix diagonalization that is relevant for independent component analysis in the underdetermined case. We present generic uniqueness conditions for a recently proposed class of deterministic blind source separation methods that rely on mild source models. For the interested reader we provide some intuition on how the results are connected to their algebraic geometric roots.

  20. An Operational Investigation of the CPS Hierarchy

    DEFF Research Database (Denmark)

    Danvy, Olivier; Yang, Zhe

    1999-01-01

    We explore the hierarchy of control induced by successive transformations into continuation-passing style (CPS) in the presence of “control delimiters ” and “composable continuations ”. Specifically, we investigate the structural operational semantics associated with the CPS hierarchy. To this en...... a native and modular implementation of the entire hierarchy. We illustrate it with several examples, the most significant of which is layered monads....

  1. An Operational Investigation of the CPS Hierarchy

    DEFF Research Database (Denmark)

    Danvy, Olivier; Yang, Zhe

    1998-01-01

    We explore the hierarchy of control induced by successive transformations into continuation-passing style (CPS) in the presence of “control delimiters ” and “composable continuations ”. Specifically, we investigate the structural operational semantics associated with the CPS hierarchy. To this end...... a native and modular implementation of the entire hierarchy. We illustrate it with several examples, the most significant of which is layered monads....

  2. Solving Sparse Polynomial Optimization Problems with Chordal Structure Using the Sparse, Bounded-Degree Sum-of-Squares Hierarchy

    NARCIS (Netherlands)

    Marandi, Ahmadreza; de Klerk, Etienne; Dahl, Joachim

    The sparse bounded degree sum-of-squares (sparse-BSOS) hierarchy of Weisser, Lasserre and Toh [arXiv:1607.01151,2016] constructs a sequence of lower bounds for a sparse polynomial optimization problem. Under some assumptions, it is proven by the authors that the sequence converges to the optimal

  3. On the Half Shell: An Introduction to Oysters and Their Unique Structures and Function

    Science.gov (United States)

    Frederick, J. Adam; Haines, Sarah; Romano, Christina; Takacs, Jacqueline

    2017-01-01

    The eastern oyster, "Crassostrea virginica," is an ecologically and economically important species in Chesapeake Bay. Oysters are ecologically unique in the Chesapeake Bay because they build a structure known as a bar or reef by attaching to one another over a 45 long period of time. They have been coined the "Ecological Engineers…

  4. On the Half Shell: An Introduction to Oysters and Their Unique Structures and Function

    Science.gov (United States)

    Frederick, J. Adam; Haines, Sarah; Romano, Christina; Takacs, Jacqueline

    2017-01-01

    The eastern oyster, "Crassostrea virginica," is an ecologically and economically important species in Chesapeake Bay. Oysters are ecologically unique in the Chesapeake Bay because they build a structure known as a bar or reef by attaching to one another over a 45 long period of time. They have been coined the "Ecological Engineers…

  5. EXISTENCE AND UNIQUENESS OF ENDEMIC STATES FOR THE AGE-STRUCTURED SEIR EPIDEMIC MODEL

    Institute of Scientific and Technical Information of China (English)

    Xuezhi LI; Jing CHEN

    2006-01-01

    An age-structured SEIR epidemic model of a vertically as well as horizontally transmitted disease is investigated. Threshold results for the existence of endemic states are established for most cases. Under certain conditions, uniqueness is also shown. Threshold used are explicitly computable in term of demographic and epidemiological parameters of the model.

  6. Exploiting Unique Structural and Functional Properties of Malarial Glycolytic Enzymes for Antimalarial Drug Development

    Directory of Open Access Journals (Sweden)

    Asrar Alam

    2014-01-01

    Full Text Available Metabolic enzymes have been known to carry out a variety of functions besides their normal housekeeping roles known as “moonlighting functions.” These functionalities arise from structural changes induced by posttranslational modifications and/or binding of interacting proteins. Glycolysis is the sole source of energy generation for malaria parasite Plasmodium falciparum, hence a potential pathway for therapeutic intervention. Crystal structures of several P. falciparum glycolytic enzymes have been solved, revealing that they exhibit unique structural differences from the respective host enzymes, which could be exploited for their selective targeting. In addition, these enzymes carry out many parasite-specific functions, which could be of potential interest to control parasite development and transmission. This review focuses on the moonlighting functions of P. falciparum glycolytic enzymes and unique structural differences and functional features of the parasite enzymes, which could be exploited for therapeutic and transmission blocking interventions against malaria.

  7. Exploiting Unique Structural and Functional Properties of Malarial Glycolytic Enzymes for Antimalarial Drug Development

    Science.gov (United States)

    Neyaz, Md. Kausar; Ikramul Hasan, Syed

    2014-01-01

    Metabolic enzymes have been known to carry out a variety of functions besides their normal housekeeping roles known as “moonlighting functions.” These functionalities arise from structural changes induced by posttranslational modifications and/or binding of interacting proteins. Glycolysis is the sole source of energy generation for malaria parasite Plasmodium falciparum, hence a potential pathway for therapeutic intervention. Crystal structures of several P. falciparum glycolytic enzymes have been solved, revealing that they exhibit unique structural differences from the respective host enzymes, which could be exploited for their selective targeting. In addition, these enzymes carry out many parasite-specific functions, which could be of potential interest to control parasite development and transmission. This review focuses on the moonlighting functions of P. falciparum glycolytic enzymes and unique structural differences and functional features of the parasite enzymes, which could be exploited for therapeutic and transmission blocking interventions against malaria. PMID:25580350

  8. Generalized NLS Hierarchies from Rational $W$ Algebras

    CERN Document Server

    Toppan, F

    1994-01-01

    Finite rational $\\cw$ algebras are very natural structures appearing in coset constructions when a Kac-Moody subalgebra is factored out. In this letter we address the problem of relating these algebras to integrable hierarchies of equations, by showing how to associate to a rational $\\cw$ algebra its corresponding hierarchy. We work out two examples: the $sl(2)/U(1)$ coset, leading to the Non-Linear Schr\\"{o}dinger hierarchy, and the $U(1)$ coset of the Polyakov-Bershadsky $\\cw$ algebra, leading to a $3$-field representation of the KP hierarchy already encountered in the literature. In such examples a rational algebra appears as algebra of constraints when reducing a KP hierarchy to a finite field representation. This fact arises the natural question whether rational algebras are always associated to such reductions and whether a classification of rational algebras can lead to a classification of the integrable hierarchies.

  9. Unique Concept for a Low Cost, Light Weight Space Deployable Antenna Structure

    Science.gov (United States)

    Freeland, Robert E.; Bilyeu, Gayle D.; Veal, Gordon R.

    1993-01-01

    Large space deployable antennas are needed for a variety of applications that include Mobile Communications, Radiometry, Active Microwave Sensing, Very Long Baseline Interferometry and DoD Space Based Radar. These user requirements identify the need for structures up to tens of meters in size for operation from 1 to 90 GHz, based on different aperture configurations. However, the one thing the users have in common is a concept selection criteria for low cost, light weight and highly reliable deployable structures. Fortunately, a unique class of space structures has recently emerged that have tremendous potential for satisfying these criteria. They are referred to as inflatable deployable structures.

  10. Discovery of a Structurally Unique Small Molecule that Inhibits Protein Synthesis

    Science.gov (United States)

    Thakral, Durga; Tae, Hyun Seop

    2017-01-01

    Identifying and characterizing natural products and synthetic small molecules that inhibit biochemical processes such as ribosomal translation can lead to novel sources of molecular probes and therapeutics. The search for new antibiotics has been invigorated by the increasing burden of drug-resistant bacteria and has identified many clinically essential prokaryote-specific ribosome inhibitors. However, the current cohort of antibiotics is limited with regards to bacterial resistance mechanisms because of structural similarity within classes. From a high-throughput screen for translation inhibitors, we discovered a new compound, T6102, which inhibits bacterial protein synthesis in vitro, inhibits bacterial growth of Bacillus subtilis in vivo, and has a chemical structure that appears to be unique among known classes of translation-inhibiting antibiotics. T6102’s unique structure compared to current clinically-utilized antibiotics makes it an exciting new candidate for the development of next-generation antibiotics.

  11. A descending hierarchy of reflection principles

    NARCIS (Netherlands)

    Visser, A.

    2008-01-01

    This paper can best be viewed as a portrait in miniature of a fascinating structure: a. descending hierarchy of reflection principles. Ascending hierarchies of reflection principles are amply studied, e.g. in Feferman's great paper Transfinite Recursive Progressions of Axiomatic Theories (Feferman[l

  12. Mathematical hierarchies and biology

    CERN Document Server

    Mirkin, Boris; Roberts, Fred S; Roberts, Fred S; Rzhetsky, Andrey

    1997-01-01

    The mathematical approach to the study of hierarchies presents the theoretical basis for many important areas of current scientific investigation. Biology has benefited from this research and has also stimulated the mathematical study of hierarchies. This collection presents papers devoted to theoretical, algorithmical, and application issues related to (1) reconstructing hierarchies (trees or ranking) from (dis)similarity or entity-to-character data, (2) using hierarchies for modeling evolution and other processes, and (3) combining (gene) trees. The papers in this volume provide a contemporary sample of many new results in hierarchy theory with applications in biology, psychology, data analysis, and systems engineering. Features: Mathematical treatment of hierarchies in several interconnected frameworks: set systems, linear subspaces, graph objects, and tree metrics. The relationship of hierarchies to many issues of current application-from learning robots to wavelets to intron evolution to the evolution ...

  13. Domain Hierarchy of Protein Loop-Lock Structure (DHoPLLS): a server for decomposition of a protein structure on set of closed loops

    CERN Document Server

    Kogan, Simon

    2011-01-01

    DHoPLLS (http://leah.haifa.ac.il/~skogan/Apache/mydata1/main.html) is a web server that identifies closed loops, which constitute a structural basis for the protein domain hierarchy. The server was created in 2005 year on basis Prof. Trifonov's lab in Genome Diversity Center, Institute of Evolution at University of Haifa. It is based on theory of loop-lock structure developed by Prof. Trifonov's group in Weizmann Institute of Science. This theory declares that all globular protein can be decomposed on set of almost closed loop with mean length about 30 aminoacids. The lock is a place, where a loop meets itself. Investigations of Trifonov's group demonstrates that some aminoacid's sequences (about 30 aminoacids) are usually exists in proteins in form of closed loops. On basis computer programs, developed for the server, we checked the simplest assumption that most of closed loop or locks in proteins have some alphabet of consensus sequences. Unfortunately our results demonstrate that such alphabet doesn't exis...

  14. Structural Perspectives on the Evolutionary Expansion of Unique Protein-Protein Binding Sites.

    Science.gov (United States)

    Goncearenco, Alexander; Shaytan, Alexey K; Shoemaker, Benjamin A; Panchenko, Anna R

    2015-09-15

    Structures of protein complexes provide atomistic insights into protein interactions. Human proteins represent a quarter of all structures in the Protein Data Bank; however, available protein complexes cover less than 10% of the human proteome. Although it is theoretically possible to infer interactions in human proteins based on structures of homologous protein complexes, it is still unclear to what extent protein interactions and binding sites are conserved, and whether protein complexes from remotely related species can be used to infer interactions and binding sites. We considered biological units of protein complexes and clustered protein-protein binding sites into similarity groups based on their structure and sequence, which allowed us to identify unique binding sites. We showed that the growth rate of the number of unique binding sites in the Protein Data Bank was much slower than the growth rate of the number of structural complexes. Next, we investigated the evolutionary roots of unique binding sites and identified the major phyletic branches with the largest expansion in the number of novel binding sites. We found that many binding sites could be traced to the universal common ancestor of all cellular organisms, whereas relatively few binding sites emerged at the major evolutionary branching points. We analyzed the physicochemical properties of unique binding sites and found that the most ancient sites were the largest in size, involved many salt bridges, and were the most compact and least planar. In contrast, binding sites that appeared more recently in the evolution of eukaryotes were characterized by a larger fraction of polar and aromatic residues, and were less compact and more planar, possibly due to their more transient nature and roles in signaling processes.

  15. Non-redundant unique interface structures as templates for modeling protein interactions

    OpenAIRE

    Engin Cukuroglu; Attila Gursoy; Ruth Nussinov; Ozlem Keskin

    2014-01-01

    Non-Redundant Unique Interface Structures as Templates for Modeling Protein Interactions Engin Cukuroglu1, Attila Gursoy1*, Ruth Nussinov2,3, Ozlem Keskin1* 1 Center for Computational Biology and Bioinformatics and College of Engineering, Koc University, Istanbul, Turkey, 2 National Cancer Institute, Cancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., National Cancer Institute, Frederick, Maryland, United States of ...

  16. Hierarchy and information in feedforward networks

    CERN Document Server

    Corominas-Murtra, Bernat; Rodríguez-Caso, Carlos; Solé, Ricard

    2010-01-01

    In this paper we define a hierarchical index for feedforward structures taking, as the starting point, three fundamental concepts underlying hierarchy: order, predictability and pyramidal structure. Our definition applies to the so called causal graphs, i.e., connected, directed acyclic graphs in which the arrows depict a direct causal relation between two elements defining the nodes. The estimator of hierarchy is obtained by evaluating the complexity of causal paths against the uncertainty in recovering them from a given end point. This naturally leads us to a definition of mutual information which, properly normalized and weighted through the layered structure of the graph, results in suitable index of hierarchy with strong theoretical grounds.

  17. Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4

    DEFF Research Database (Denmark)

    McDonough, Michael A.; Kadirvelraj, Renuka; Harris, Pernille

    2004-01-01

    Rhamnogalacturonan lyase (RG-lyase) specifically recognizes and cleaves alpha-1,4 glycosidic bonds between L-rhamnose and D-galacturonic acids in the backbone of rhamno galacturonan-I, a major component of the plant cell wall polysaccharide, pectin. The three-dimensional structure of RG-lyase fro...... structural homology to non-catalytic domains from other carbohydrate active enzymes.......Rhamnogalacturonan lyase (RG-lyase) specifically recognizes and cleaves alpha-1,4 glycosidic bonds between L-rhamnose and D-galacturonic acids in the backbone of rhamno galacturonan-I, a major component of the plant cell wall polysaccharide, pectin. The three-dimensional structure of RG-lyase from...... Aspergillus aculeatus has been determined to 1.5 Angstrom resolution representing the first known structure from polysaccharide lyase family 4 and of an enzyme with this catalytic specificity. The 508-amino acid polypeptide displays a unique arrangement of three distinct modular domains. Each domain shows...

  18. Vector Loop Algebra and Its Applications to Tu Hierarchy

    Institute of Scientific and Technical Information of China (English)

    WANG Yan

    2007-01-01

    A vector loop algebra and its extended loop algebra are proposed, which are devoted to obtaining the Tu hierarchy. By making use of the extended trace identity, the Hamiltonian structure of the Tu hierarchy is constructed.Furthermore, we apply the quadratic-form identity to the integrable coupling system of the Tu hierarchy.

  19. The concept of hierarchy in general systems theory.

    Science.gov (United States)

    Gasparski, W

    1994-01-01

    The paper reviews main ideas related to the concept of hierarchy as they are discussed in contemporary general systems theory. After presenting a dictionary definition of the concept, the author examines the intuitive idea of hierarchy quoting Mario Bunge's notion of level structure. Then relationship between two other concepts: a system and a hierarchy is characterised on the bases of Bowler's, Bunge's again, Klir's, and the author's studies. Finally, the paper is concluded that hierarchy is not an otological concept but epistemological one.

  20. Uranium(VI) coordination polymers with pyromellitate ligand: Unique 1D channel structures and diverse fluorescence

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yingjie, E-mail: yzx@ansto.gov.au [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia); Bhadbhade, Mohan [Mark Wainwright Analytical Centre, University of New South Wales, Kensington, NSW 2052 (Australia); Karatchevtseva, Inna [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia); Price, Jason R. [Australian Synchrotron, 800 Blackburn Road, Clayton, VIC 3168 (Australia); Liu, Hao [Centre for Clean Energy Technology, School of Chemistry and Forensic Science, University of Technology Sydney, PO Box 123, Broadway, Sydney, NSW 2007 (Australia); Zhang, Zhaoming; Kong, Linggen [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia); Čejka, Jiří [Department of Mineralogy, National Museum, Václavské náměstí, 68, Prague 1, 115 79-CZ (Czech Republic); Lu, Kim; Lumpkin, Gregory R. [Australian Nuclear Science and Technology Organization, Locked Bag 2001, Kirrawee DC, NSW 2232 (Australia)

    2015-03-15

    Three new coordination polymers of uranium(VI) with pyromellitic acid (H{sub 4}btca) have been synthesized and structurally characterized. (ED)[(UO{sub 2})(btca)]·(DMSO)·3H{sub 2}O (1) (ED=ethylenediammonium; DMSO=dimethylsulfoxide) has a lamellar structure with intercalation of ED and DMSO. (NH{sub 4}){sub 2}[(UO{sub 2}){sub 6}O{sub 2}(OH){sub 6}(btca)]·~6H{sub 2}O (2) has a 3D framework built from 7-fold coordinated uranyl trinuclear units and btca ligands with 1D diamond-shaped channels (~8.5 Å×~8.6 Å). [(UO{sub 2}){sub 2}(H{sub 2}O)(btca)]·4H{sub 2}O (3) has a 3D network constructed by two types of 7-fold coordinated uranium polyhedron. The unique μ{sub 5}-coordination mode of btca in 3 enables the formation of 1D olive-shaped large channels (~4.5 Å×~19 Å). Vibrational modes, thermal stabilities and fluorescence properties have been investigated. - Graphical abstract: Table of content: three new uranium(VI) coordination polymers with pyromellitic acid (H{sub 4}btca) have been synthesized via room temperature and hydrothermal synthesis methods, and structurally characterized. Two to three dimensional (3D) frameworks are revealed. All 3D frameworks have unique 1D large channels. Their vibrational modes, thermal stabilities and photoluminescence properties have been investigated. - Highlights: • Three new coordination polymers of U(VI) with pyromellitic acid (H{sub 4}btca). • Structures from a 2D layer to 3D frameworks with unique 1D channels. • Unusual µ{sub 5}-(η{sub 1}:η{sub 2}:η{sub 1}:η{sub 2:}η{sub 1}) coordination mode of btca ligand. • Vibrational modes, thermal stabilities and luminescent properties reported.

  1. Detectability of ranking hierarchies in directed networks

    CERN Document Server

    Letizia, Elisa; Lillo, Fabrizio

    2016-01-01

    Identifying hierarchies and rankings of nodes in directed graphs is fundamental in many applications such as social network analysis, biology, economics, and finance. A recently proposed method identifies the hierarchy by finding the ordered partition of nodes which minimizes a score function, termed agony. This function penalizes the links violating the hierarchy in a way depending on the strength of the violation. To investigate the detectability of ranking hierarchies we introduce an ensemble of random graphs, the Hierarchical Stochastic Block Model. We find that agony may fail to identify hierarchies when the structure is not strong enough and the size of the classes is small with respect to the whole network. We analytically characterize the detectability threshold and we show that an iterated version of agony can partly overcome this resolution limit.

  2. Unique structure and optics of the lesser eyes of the box jellyfish Tripedalia cystophora

    DEFF Research Database (Denmark)

    Garm, A; Andersson, F; Nilsson, Dan-E

    2008-01-01

    The visual system of box jellyfish comprises a total of 24 eyes. These are of four types and each probably has a special function. To investigate this hypothesis the morphology and optics of the lesser eyes, the pit and slit eyes, were examined. The pit eyes hold one cell type only and are probably...... mere light meters. The slit eyes, comprising four cell types, are complex and highly asymmetric. They also hold a lens-like structure, but its optical power is minute. Optical modeling suggests spatial resolution, but only in one plane. These unique and intriguing traits support strong peripheral...

  3. The Analytical Hierarchy Process

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn

    2007-01-01

    The technical note gathers the theory behind the Analytical Hierarchy Process (AHP) and present its advantages and disadvantages in practical use.......The technical note gathers the theory behind the Analytical Hierarchy Process (AHP) and present its advantages and disadvantages in practical use....

  4. The Analytical Hierarchy Process

    DEFF Research Database (Denmark)

    Barfod, Michael Bruhn

    2007-01-01

    The technical note gathers the theory behind the Analytical Hierarchy Process (AHP) and present its advantages and disadvantages in practical use.......The technical note gathers the theory behind the Analytical Hierarchy Process (AHP) and present its advantages and disadvantages in practical use....

  5. The Evolutionary Origins of Hierarchy.

    Science.gov (United States)

    Mengistu, Henok; Huizinga, Joost; Mouret, Jean-Baptiste; Clune, Jeff

    2016-06-01

    Hierarchical organization-the recursive composition of sub-modules-is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments). Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force-the cost of connections-promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics.

  6. The Evolutionary Origins of Hierarchy.

    Directory of Open Access Journals (Sweden)

    Henok Mengistu

    2016-06-01

    Full Text Available Hierarchical organization-the recursive composition of sub-modules-is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments. Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force-the cost of connections-promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics.

  7. The Evolutionary Origins of Hierarchy.

    Directory of Open Access Journals (Sweden)

    Henok Mengistu

    2016-06-01

    Full Text Available Hierarchical organization-the recursive composition of sub-modules-is ubiquitous in biological networks, including neural, metabolic, ecological, and genetic regulatory networks, and in human-made systems, such as large organizations and the Internet. To date, most research on hierarchy in networks has been limited to quantifying this property. However, an open, important question in evolutionary biology is why hierarchical organization evolves in the first place. It has recently been shown that modularity evolves because of the presence of a cost for network connections. Here we investigate whether such connection costs also tend to cause a hierarchical organization of such modules. In computational simulations, we find that networks without a connection cost do not evolve to be hierarchical, even when the task has a hierarchical structure. However, with a connection cost, networks evolve to be both modular and hierarchical, and these networks exhibit higher overall performance and evolvability (i.e. faster adaptation to new environments. Additional analyses confirm that hierarchy independently improves adaptability after controlling for modularity. Overall, our results suggest that the same force-the cost of connections-promotes the evolution of both hierarchy and modularity, and that these properties are important drivers of network performance and adaptability. In addition to shedding light on the emergence of hierarchy across the many domains in which it appears, these findings will also accelerate future research into evolving more complex, intelligent computational brains in the fields of artificial intelligence and robotics.

  8. The Star Height Hierarchy Vs. The Variable Hierarchy

    OpenAIRE

    Belkhir, Walid

    2009-01-01

    The star height hierarchy (resp. the variable hierarchy) results in classifying $\\mu$-terms into classes according to the nested depth of fixed point operators (resp. to the number of bound variables). We prove, under some assumptions, that the variable hierarchy is a proper refinement of the star height hierarchy. We mean that the non collapse of the variable hierarchy implies the non collapse of the star height hierarchy. The proof relies on the combinatorial characterization of the two hie...

  9. AN INTEGRATED APPROACH OF INTERPRETIVE STRUCTURAL MODELING (ISM AND ANALYTIC HIERARCHY PROCESS (AHP IN DEVELOPING INSTITUTIONAL SYSTEM OF THE BEEF CATTLE INDUSTRY

    Directory of Open Access Journals (Sweden)

    Rimbun Sumarsono

    2016-04-01

    Full Text Available This study is aimed to knowing Structuring the sub element of Institutional System of Beef Cattle Industry, The methods used for data collection is by distributing questionnaires, interviews with experts and literature studies. Results of questionnaires and interviews with experts used to construct a hierarchy of election strategy Beef Cattle industry development. Preparation of hierarchy elections industrial development strategy Beef Cattle using AHP technique The formulation of a model institutional system Beef Cattle industry development with key elements in the element's goal is to realize a strong institutional element is the need for government support, elements of the perpetrator is a trader. While the key elements in the benchmarks is the increasing diversification of products Beef Cattle, element of constraint is the weak institutional system, lack of government support for industrial development Beef Cattle and the lack of guidance to the Breeders. For elements of the desired changes to the industrial development Beef Cattle is the formation of an independent group of cattle at the planting site Beef Cattle

  10. The Generalization of Mutual Information as the Information between a Set of Variables: The Information Correlation Function Hierarchy and the Information Structure of Multi-Agent Systems

    Science.gov (United States)

    Wolf, David R.

    2004-01-01

    The topic of this paper is a hierarchy of information-like functions, here named the information correlation functions, where each function of the hierarchy may be thought of as the information between the variables it depends upon. The information correlation functions are particularly suited to the description of the emergence of complex behaviors due to many- body or many-agent processes. They are particularly well suited to the quantification of the decomposition of the information carried among a set of variables or agents, and its subsets. In more graphical language, they provide the information theoretic basis for understanding the synergistic and non-synergistic components of a system, and as such should serve as a forceful toolkit for the analysis of the complexity structure of complex many agent systems. The information correlation functions are the natural generalization to an arbitrary number of sets of variables of the sequence starting with the entropy function (one set of variables) and the mutual information function (two sets). We start by describing the traditional measures of information (entropy) and mutual information.

  11. Responsibility and Task Structuring as the Basic Attributes of Learning Styles and Their Relation Towards Consistency and the Quality of Hierarchy of a Learner’s Mind Map

    Directory of Open Access Journals (Sweden)

    Duchovičová Jana

    2016-08-01

    Full Text Available The study focuses on the identification of the relationship between the learning style and mental representation of curriculum content. The research problem identifies the relationship between the learning style factors - responsibility and task structuring and the selected categories of curriculum content representation - consistency and the quality of hierarchy identified through mind mapping. For the purposes of the research, we used the LSI Questionnaire by R. Dunn, K. Dunn and G. E. Price, a mind mapping test and chi-square statistics were used for the evaluation of research findings. The research sample consisted of 115 respondents. By means of analysis, we found out that a learning style in the observed factors of responsibility and task structuring does not influence students’ mental representation of the curriculum content.

  12. Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18

    Science.gov (United States)

    Guo, Peng-Chao; Dong, Zhaoming; Zhao, Ping; Zhang, Yan; He, Huawei; Tan, Xiang; Zhang, Weiwei; Xia, Qingyou

    2015-01-01

    Serpins generally serve as inhibitors that utilize a mobile reactive center loop (RCL) as bait to trap protease targets. Here, we present the crystal structure of serpin18 from Bombyx mori at 1.65 Å resolution, which has a very short and stable RCL. Activity analysis showed that the inhibitory target of serpin18 is a cysteine protease rather than a serine protease. Notably, this inhibitiory reaction results from the formation of an intermediate complex, which then follows for the digestion of protease and inhibitor into small fragments. This activity differs from previously reported modes of inhibition for serpins. Our findings have thus provided novel structural insights into the unique inhibitory mechanism of serpin18. Furthermore, one physiological target of serpin18, fibroinase, was identified, which enables us to better define the potential role for serpin18 in regulating fibroinase activity during B. mori development. PMID:26148664

  13. Short Cycle Structure of Graphs on Surfaces (1)-the Uniqueness Theorems

    Institute of Scientific and Technical Information of China (English)

    Han Ren; Mo Deng

    2008-01-01

    In this paper we investigate cycle base structures of a (weighted) graph and show that much information of short cycles is contained in a MCB (minimum cycle base). After setting up a Hall type theorem for base-transformation, we give a sufficient and necessary condition for a cycle base to be a MCB. Further more, we show that the structure of MCB in a (weighted) graph is unique. In the case of nonnegative weight,every pair of MCB have the same number of k-cycles for each integer k>3. The property is also true for those having longest length (although much work has been down in evaluating MCB, little is known for those having longest length).

  14. Unique structural modulation of a non-native substrate by cochaperone DnaJ.

    Science.gov (United States)

    Tiwari, Satyam; Kumar, Vignesh; Jayaraj, Gopal Gunanathan; Maiti, Souvik; Mapa, Koyeli

    2013-02-12

    The role of bacterial DnaJ protein as a cochaperone of DnaK is strongly appreciated. Although DnaJ unaccompanied by DnaK can bind unfolded as well as native substrate proteins, its role as an individual chaperone remains elusive. In this study, we demonstrate that DnaJ binds a model non-native substrate with a low nanomolar dissociation constant and, more importantly, modulates the structure of its non-native state. The structural modulation achieved by DnaJ is different compared to that achieved by the DnaK-DnaJ complex. The nature of structural modulation exerted by DnaJ is suggestive of a unique unfolding activity on the non-native substrate by the chaperone. Furthermore, we demonstrate that the zinc binding motif along with the C-terminal substrate binding domain of DnaJ is necessary and sufficient for binding and the subsequent binding-induced structural alterations of the non-native substrate. We hypothesize that this hitherto unknown structural alteration of non-native states by DnaJ might be important for its chaperoning activity by removing kinetic traps of the folding intermediates.

  15. Diagonal gates in the Clifford hierarchy

    Science.gov (United States)

    Cui, Shawn X.; Gottesman, Daniel; Krishna, Anirudh

    2017-01-01

    The Clifford hierarchy is a set of gates that appears in the theory of fault-tolerant quantum computation, but its precise structure remains elusive. We give a complete characterization of the diagonal gates in the Clifford hierarchy for prime-dimensional qudits. They turn out to be pmth roots of unity raised to polynomial functions of the basis state to which they are applied, and we determine which level of the Clifford hierarchy a given gate sits in based on m and the degree of the polynomial.

  16. A Secure Dynamic Access Control Scheme for the Hierarchy Structure%一种针对层次结构的安全动态存取控制方案

    Institute of Scientific and Technical Information of China (English)

    施荣华

    2002-01-01

    Based on both the Rabin's scheme and the Chinese remainder theorem, this paper presents a secure accesscontrol scheme for the hierarchy structure. Compared to the existing access control schemes, the scheme's key gener-ation algorithm and derivation algorithm of successor's keys are simple. In the scheme, the predecessor not only canefficiently derive secret keys of its successors, but also can withstand the attack of collusion. The scheme's dynamicfeature is perfect. Moreover, each security class in hierarchy structure can freely select/change his own key withoutaltering other keys present in the system.

  17. Memory Hierarchy Sensitive Graph Layout

    CERN Document Server

    Roy, Amitabha

    2012-01-01

    Mining large graphs for information is becoming an increasingly important workload due to the plethora of graph structured data becoming available. An aspect of graph algorithms that has hitherto not received much interest is the effect of memory hierarchy on accesses. A typical system today has multiple levels in the memory hierarchy with differing units of locality; ranging across cache lines, TLB entries and DRAM pages. We postulate that it is possible to allocate graph structured data in main memory in a way as to improve the spatial locality of the data. Previous approaches to improving cache locality have focused only on a single unit of locality, either the cache line or virtual memory page. On the other hand cache oblivious algorithms can optimise layout for all levels of the memory hierarchy but unfortunately need to be specially designed for individual data structures. In this paper we explore hierarchical blocking as a technique for closing this gap. We require as input a specification of the units...

  18. Structural Basis of Natural Promoter Recognition by a Unique Nuclear Receptor, HNF4[alpha

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Peng; Rha, Geun Bae; Melikishvili, Manana; Wu, Guangteng; Adkins, Brandon C.; Fried, Michael G.; Chi, Young-In (Kentucky)

    2010-11-09

    HNF4{alpha} (hepatocyte nuclear factor 4{alpha}) plays an essential role in the development and function of vertebrate organs, including hepatocytes and pancreatic {beta}-cells by regulating expression of multiple genes involved in organ development, nutrient transport, and diverse metabolic pathways. As such, HNF4{alpha} is a culprit gene product for a monogenic and dominantly inherited form of diabetes, known as maturity onset diabetes of the young (MODY). As a unique member of the nuclear receptor superfamily, HNF4{alpha} recognizes target genes containing two hexanucleotide direct repeat DNA-response elements separated by one base pair (DR1) by exclusively forming a cooperative homodimer. We describe here the 2.0 {angstrom} crystal structure of human HNF4{alpha} DNA binding domain in complex with a high affinity promoter element of another MODY gene, HNF1{alpha}, which reveals the molecular basis of unique target gene selection/recognition, DNA binding cooperativity, and dysfunction caused by diabetes-causing mutations. The predicted effects of MODY mutations have been tested by a set of biochemical and functional studies, which show that, in contrast to other MODY gene products, the subtle disruption of HNF4{alpha} molecular function can cause significant effects in afflicted MODY patients.

  19. Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells.

    Science.gov (United States)

    Butler, John T; Hall, Lisa L; Smith, Kelly P; Lawrence, Jeanne B

    2009-07-01

    The complex nuclear structure of somatic cells is important to epigenomic regulation, yet little is known about nuclear organization of human embryonic stem cells (hESC). Here we surveyed several nuclear structures in pluripotent and transitioning hESC. Observations of centromeres, telomeres, SC35 speckles, Cajal Bodies, lamin A/C and emerin, nuclear shape and size demonstrate a very different "nuclear landscape" in hESC. This landscape is remodeled during a brief transitional window, concomitant with or just prior to differentiation onset. Notably, hESC initially contain abundant signal for spliceosome assembly factor, SC35, but lack discrete SC35 domains; these form as cells begin to specialize, likely reflecting cell-type specific genomic organization. Concomitantly, nuclear size increases and shape changes as lamin A/C and emerin incorporate into the lamina. During this brief window, hESC exhibit dramatically different PML-defined structures, which in somatic cells are linked to gene regulation and cancer. Unlike the numerous, spherical somatic PML bodies, hES cells often display approximately 1-3 large PML structures of two morphological types: long linear "rods" or elaborate "rosettes", which lack substantial SUMO-1, Daxx, and Sp100. These occur primarily between Day 0-2 of differentiation and become rare thereafter. PML rods may be "taut" between other structures, such as centromeres, but clearly show some relationship with the lamina, where PML often abuts or fills a "gap" in early lamin A/C staining. Findings demonstrate that pluripotent hES cells have a markedly different overall nuclear architecture, remodeling of which is linked to early epigenomic programming and involves formation of unique PML-defined structures.

  20. Hierarchy is Detrimental for Human Cooperation.

    Science.gov (United States)

    Cronin, Katherine A; Acheson, Daniel J; Hernández, Penélope; Sánchez, Angel

    2015-12-22

    Studies of animal behavior consistently demonstrate that the social environment impacts cooperation, yet the effect of social dynamics has been largely excluded from studies of human cooperation. Here, we introduce a novel approach inspired by nonhuman primate research to address how social hierarchies impact human cooperation. Participants competed to earn hierarchy positions and then could cooperate with another individual in the hierarchy by investing in a common effort. Cooperation was achieved if the combined investments exceeded a threshold, and the higher ranked individual distributed the spoils unless control was contested by the partner. Compared to a condition lacking hierarchy, cooperation declined in the presence of a hierarchy due to a decrease in investment by lower ranked individuals. Furthermore, hierarchy was detrimental to cooperation regardless of whether it was earned or arbitrary. These findings mirror results from nonhuman primates and demonstrate that hierarchies are detrimental to cooperation. However, these results deviate from nonhuman primate findings by demonstrating that human behavior is responsive to changing hierarchical structures and suggests partnership dynamics that may improve cooperation. This work introduces a controlled way to investigate the social influences on human behavior, and demonstrates the evolutionary continuity of human behavior with other primate species.

  1. Hierarchy Measure for Complex Networks

    Science.gov (United States)

    Mones, Enys; Vicsek, Lilla; Vicsek, Tamás

    2012-01-01

    Nature, technology and society are full of complexity arising from the intricate web of the interactions among the units of the related systems (e.g., proteins, computers, people). Consequently, one of the most successful recent approaches to capturing the fundamental features of the structure and dynamics of complex systems has been the investigation of the networks associated with the above units (nodes) together with their relations (edges). Most complex systems have an inherently hierarchical organization and, correspondingly, the networks behind them also exhibit hierarchical features. Indeed, several papers have been devoted to describing this essential aspect of networks, however, without resulting in a widely accepted, converging concept concerning the quantitative characterization of the level of their hierarchy. Here we develop an approach and propose a quantity (measure) which is simple enough to be widely applicable, reveals a number of universal features of the organization of real-world networks and, as we demonstrate, is capable of capturing the essential features of the structure and the degree of hierarchy in a complex network. The measure we introduce is based on a generalization of the m-reach centrality, which we first extend to directed/partially directed graphs. Then, we define the global reaching centrality (GRC), which is the difference between the maximum and the average value of the generalized reach centralities over the network. We investigate the behavior of the GRC considering both a synthetic model with an adjustable level of hierarchy and real networks. Results for real networks show that our hierarchy measure is related to the controllability of the given system. We also propose a visualization procedure for large complex networks that can be used to obtain an overall qualitative picture about the nature of their hierarchical structure. PMID:22470477

  2. Experimental study of wind loads on unique buildings and structures in Russia

    Directory of Open Access Journals (Sweden)

    Poddaeva Olga

    2016-01-01

    Full Text Available Design and construction of unique buildings and structures (sports arenas, airport complexes, business centres, etc. from an engineering point of view is a very difficult task as in most cases these facilities have an original architectural form. Therefore, consideration of wind loads is an important part of the design. The paper presents the definition of wind load for two complex of airport. Researches was applied the combined calculation an experimental method. During the experimental study a wind tunnel architectural and construction type NRU MSUCE was used. Numerical simulations were performed using the software package ANSYS. The result of research on each object are integral aerodynamic loads on the object (coefficients Cx, Cy, Cmz and picture of the distribution of aerodynamic pressure coefficient Cp obtained in the numerical simulation. In conclusion, we discuss the possible formation of deposits of snow and recommendations to eliminate them from the roof of researched objects.

  3. Existence and uniqueness of endemic states for the age-structured S-I-R epidemic model.

    Science.gov (United States)

    Cha, Y; Iannelli, M; Milner, F A

    1998-06-15

    The existence and uniqueness of positive steady states for the age structured S-I-R epidemic model with intercohort transmission is considered. Threshold results for the existence of endemic states are established for most cases. Uniqueness is shown in each case. Threshold used are explicitly computable in terms of demographic and epidemiological parameters of the model.

  4. Dissecting structural basis of the unique substrate selectivity of human enteropeptidase catalytic subunit.

    Science.gov (United States)

    Ostapchenko, Valeriy G; Gasparian, Marine E; Kosinsky, Yurij A; Efremov, Roman G; Dolgikh, Dmitry A; Kirpichnikov, Mikhail P

    2012-01-01

    Enteropeptidase is a key enzyme in the digestion system of higher animals. It initiates enzymatic cascade cleaving trypsinogen activation peptide after a unique sequence DDDDK. Recently, we have found specific activity of human enteropeptidase catalytic subunit (L-HEP) being significantly higher than that of its bovine ortholog (L-BEP). Moreover, we have discovered that L-HEP hydrolyzed several nonspecific peptidic substrates. In this work, we aimed to further characterize species-specific enteropeptidase activities and to reveal their structural basis. First, we compared hydrolysis of peptides and proteins lacking DDDDK sequence by L-HEP and L-BEP. In each case human enzyme was more efficient, with the highest hydrolysis rate observed for substrates with a large hydrophobic residue in P2-position. Computer modeling suggested enzyme exosite residues 96 (Arg in L-HEP, Lys in L-BEP) and 219 (Lys in L-HEP, Gln in L-BEP) to be responsible for these differences in enteropeptidase catalytic activity. Indeed, human-to-bovine mutations Arg96Lys, Lys219Gln shifted catalytic properties of L-HEP toward those of L-BEP. This effect was amplified in case of the double mutation Arg96Lys/Lys219Gln, but still did not cover the full difference in catalytic activities of human and bovine enzymes. To find a missing link, we studied monopeptide benzyl-arginine-β-naphthylamide hydrolysis. L-HEP catalyzed it with an order lower K (m) than L-BEP, suggesting the monopeptide-binding S1 site input into catalytic distinction between two enteropeptidase species. Together, our findings suggest structural basis of the unique catalytic properties of human enteropeptidase and instigate further studies of its tentative physiological and pathological roles.

  5. In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits

    Science.gov (United States)

    Mühleip, Alexander W.; Dewar, Caroline E.; Schnaufer, Achim; Kühlbrandt, Werner; Davies, Karen M.

    2017-01-01

    We used electron cryotomography and subtomogram averaging to determine the in situ structures of mitochondrial ATP synthase dimers from two organisms belonging to the phylum euglenozoa: Trypanosoma brucei, a lethal human parasite, and Euglena gracilis, a photosynthetic protist. At a resolution of 32.5 Å and 27.5 Å, respectively, the two structures clearly exhibit a noncanonical F1 head, in which the catalytic (αβ)3 assembly forms a triangular pyramid rather than the pseudo-sixfold ring arrangement typical of all other ATP synthases investigated so far. Fitting of known X-ray structures reveals that this unusual geometry results from a phylum-specific cleavage of the α subunit, in which the C-terminal αC fragments are displaced by ∼20 Å and rotated by ∼30° from their expected positions. In this location, the αC fragment is unable to form the conserved catalytic interface that was thought to be essential for ATP synthesis, and cannot convert γ-subunit rotation into the conformational changes implicit in rotary catalysis. The new arrangement of catalytic subunits suggests that the mechanism of ATP generation by rotary ATPases is less strictly conserved than has been generally assumed. The ATP synthases of these organisms present a unique model system for discerning the individual contributions of the α and β subunits to the fundamental process of ATP synthesis. PMID:28096380

  6. Unique genomic structure and distinct mitotic behavior of ring chromosome 21 in two unrelated cases.

    Science.gov (United States)

    Zhang, H Z; Xu, F; Seashore, M; Li, P

    2012-01-01

    A ring chromosome replacing a normal chromosome could involve variable structural rearrangements and mitotic instability. However, most previously reported cases lacked further genomic characterization. High-resolution oligonucleotide array comparative genomic hybridization with single-nucleotide polymorphism typing (aCGH+SNP) was used to study 2 unrelated cases with a ring chromosome 21. Case 1 had severe myopia, hypotonia, joint hypermobility, speech delay, and dysmorphic features. aCGH detected a 1.275-Mb duplication of 21q22.12-q22.13 and a 6.731-Mb distal deletion at 21q22.2. Case 2 showed severe growth and developmental retardations, intractable seizures, and dysmorphic features. aCGH revealed a contiguous pattern of a 3.612- Mb deletion of 21q22.12-q22.2, a 4.568-Mb duplication of 21q22.2-q22.3, and a 2.243-Mb distal deletion at 21q22.3. Mitotic instability was noted in 13, 30, and 76% of in vitro cultured metaphase cells, interphase cells, and leukocyte DNA, respectively. The different phenotypes of these 2 cases are likely associated with the unique genomic structure and distinct mitotic behavior of their ring chromosome 21. These 2 cases represent a subtype of ring chromosome 21 probably involving somatic dicentric ring breakage and reunion. A cytogenomic approach is proposed for characterizing the genomic structure and mitotic instability of ring chromosome abnormalities.

  7. The JFFMA assessment of flavoring substances structurally related to menthol and uniquely used in Japan.

    Science.gov (United States)

    Mirokuji, Yoshiharu; Abe, Hajime; Okamura, Hiroyuki; Saito, Kenji; Sekiya, Fumiko; Hayashi, Shim-mo; Maruyama, Shinpei; Ono, Atsushi; Nakajima, Madoka; Degawa, Masakuni; Ozawa, Shogo; Shibutani, Makoto; Maitani, Tamio

    2014-02-01

    Using the procedure devised by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), we performed safety evaluations on four flavoring substances structurally related to menthol (L-menthyl 2-methylbutyrate, DL-menthyl octanoate, DL-menthyl palmitate, and DL-menthyl stearate) uniquely used in Japan. While no genotoxicity study data were available in the literature, all four substances had no chemical structural alerts predictive of genotoxicity. Moreover, they all four are esters consisting of menthol and simple carboxylic acids that were assumed to be immediately hydrolyzed after ingestion and metabolized into innocuous substances for excretion. As menthol and carboxylic acids have no known genotoxicity, it was judged that the JECFA procedure could be applied to these four substances. According to Cramer's classification, these substances were categorized as class I based on their chemical structures. The estimated daily intakes for all four substances were within the range of 1.54-4.71 μg/person/day and 60-1250 μg/person/day, using the methods of Maximized Survey-Derived Intake and Single Portion Exposure Technique, respectively, based on the annual usage data of 2001, 2005, and 2010 in Japan. As the daily intakes of these substances were below the threshold of concern applied to class I substances viz., 1800 μg/person/day, it was concluded that all four substances raise no safety concerns when used for flavoring foods under the currently estimated intake levels.

  8. Extracting tag hierarchies.

    Directory of Open Access Journals (Sweden)

    Gergely Tibély

    Full Text Available Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy between the tags. The encouraging similarity between the pre-defined and reconstructed hierarchy, as well as the seemingly meaningful hierarchies obtained for other real systems indicate that tag hierarchy extraction is a very promising direction for further research with a great potential for practical applications. Tags have become very prevalent nowadays in various online platforms ranging from blogs through scientific publications to protein databases. Furthermore, tagging systems dedicated for voluntary tagging of photos, films, books, etc. with free words are also becoming popular. The emerging large collections of tags associated with different objects are often referred to as folksonomies, highlighting their collaborative origin and the "flat" organization of the tags opposed to traditional hierarchical categorization. Adding a tag hierarchy corresponding to a given folksonomy can very effectively help narrowing or broadening the scope of

  9. Extracting tag hierarchies.

    Science.gov (United States)

    Tibély, Gergely; Pollner, Péter; Vicsek, Tamás; Palla, Gergely

    2013-01-01

    Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy between the tags. The encouraging similarity between the pre-defined and reconstructed hierarchy, as well as the seemingly meaningful hierarchies obtained for other real systems indicate that tag hierarchy extraction is a very promising direction for further research with a great potential for practical applications. Tags have become very prevalent nowadays in various online platforms ranging from blogs through scientific publications to protein databases. Furthermore, tagging systems dedicated for voluntary tagging of photos, films, books, etc. with free words are also becoming popular. The emerging large collections of tags associated with different objects are often referred to as folksonomies, highlighting their collaborative origin and the "flat" organization of the tags opposed to traditional hierarchical categorization. Adding a tag hierarchy corresponding to a given folksonomy can very effectively help narrowing or broadening the scope of search. Moreover

  10. Extracting Tag Hierarchies

    Science.gov (United States)

    Tibély, Gergely; Pollner, Péter; Vicsek, Tamás; Palla, Gergely

    2013-01-01

    Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy between the tags. The encouraging similarity between the pre-defined and reconstructed hierarchy, as well as the seemingly meaningful hierarchies obtained for other real systems indicate that tag hierarchy extraction is a very promising direction for further research with a great potential for practical applications. Tags have become very prevalent nowadays in various online platforms ranging from blogs through scientific publications to protein databases. Furthermore, tagging systems dedicated for voluntary tagging of photos, films, books, etc. with free words are also becoming popular. The emerging large collections of tags associated with different objects are often referred to as folksonomies, highlighting their collaborative origin and the “flat” organization of the tags opposed to traditional hierarchical categorization. Adding a tag hierarchy corresponding to a given folksonomy can very effectively help narrowing or broadening the scope of search

  11. Amplification of local changes along the timescale processing hierarchy.

    Science.gov (United States)

    Yeshurun, Yaara; Nguyen, Mai; Hasson, Uri

    2017-08-29

    Small changes in word choice can lead to dramatically different interpretations of narratives. How does the brain accumulate and integrate such local changes to construct unique neural representations for different stories? In this study, we created two distinct narratives by changing only a few words in each sentence (e.g., "he" to "she" or "sobbing" to "laughing") while preserving the grammatical structure across stories. We then measured changes in neural responses between the two stories. We found that differences in neural responses between the two stories gradually increased along the hierarchy of processing timescales. For areas with short integration windows, such as early auditory cortex, the differences in neural responses between the two stories were relatively small. In contrast, in areas with the longest integration windows at the top of the hierarchy, such as the precuneus, temporal parietal junction, and medial frontal cortices, there were large differences in neural responses between stories. Furthermore, this gradual increase in neural differences between the stories was highly correlated with an area's ability to integrate information over time. Amplification of neural differences did not occur when changes in words did not alter the interpretation of the story (e.g., sobbing to "crying"). Our results demonstrate how subtle differences in words are gradually accumulated and amplified along the cortical hierarchy as the brain constructs a narrative over time.

  12. Europium-based iron pnictides: a unique laboratory for magnetism, superconductivity and structural effects.

    Science.gov (United States)

    Zapf, Sina; Dressel, Martin

    2017-01-01

    Despite decades of intense research, the origin of high-temperature superconductivity in cuprates and iron-based compounds is still a mystery. Magnetism and superconductivity are traditionally antagonistic phenomena; nevertheless, there is basically no doubt left that unconventional superconductivity is closely linked to magnetism. But this is not the whole story; recently, also structural effects related to the so-called nematic phase gained considerable attention. In order to obtain more information about this peculiar interplay, systematic material research is one of the most important attempts, revealing from time to time unexpected effects. Europium-based iron pnictides are the latest example of such a completely paradigmatic material, as they display not only spin-density-wave and superconducting ground states, but also local Eu(2+) magnetism at a similar temperature scale. Here we review recent experimental progress in determining the complex phase diagrams of europium-based iron pnictides. The conclusions drawn from the observations reach far beyond these model systems. Thus, although europium-based iron pnictides are very peculiar, they provide a unique platform to study the common interplay of structural-nematic, magnetic and electronic effects in high-temperature superconductors.

  13. Aphis Glycines Virus 2, a Novel Insect Virus with a Unique Genome Structure

    Directory of Open Access Journals (Sweden)

    Sijun Liu

    2016-11-01

    Full Text Available The invasive soybean aphid, Aphis glycines, is a major pest in soybeans, resulting in substantial economic loss. We analyzed the A. glycines transcriptome to identify sequences derived from viruses of A. glycines. We identified sequences derived from a novel virus named Aphis glycines virus 2 (ApGlV2. The assembled virus genome sequence was confirmed by reverse transcription polymerase chain reaction (RT-PCR and Sanger sequencing, conserved domains were characterized, and distribution, and transmission examined. This virus has a positive sense, single-stranded RNA genome of ~4850 nt that encodes three proteins. The RNA-dependent RNA polymerase (RdRp of ApGlV2 is a permuted RdRp similar to those of some tetraviruses, while the capsid protein is structurally similar to the capsid proteins of plant sobemoviruses. ApGlV2 also encodes a larger minor capsid protein, which is translated by a readthrough mechanism. ApGlV2 appears to be widespread in A. glycines populations and to persistently infect aphids with a 100% vertical transmission rate. ApGlV2 is susceptible to the antiviral RNA interference (RNAi pathway. This virus, with its unique genome structure with both plant- and insect-virus characteristics, is of particular interest from an evolutionary standpoint.

  14. Europium-based iron pnictides: a unique laboratory for magnetism, superconductivity and structural effects

    Science.gov (United States)

    Zapf, Sina; Dressel, Martin

    2017-01-01

    Despite decades of intense research, the origin of high-temperature superconductivity in cuprates and iron-based compounds is still a mystery. Magnetism and superconductivity are traditionally antagonistic phenomena; nevertheless, there is basically no doubt left that unconventional superconductivity is closely linked to magnetism. But this is not the whole story; recently, also structural effects related to the so-called nematic phase gained considerable attention. In order to obtain more information about this peculiar interplay, systematic material research is one of the most important attempts, revealing from time to time unexpected effects. Europium-based iron pnictides are the latest example of such a completely paradigmatic material, as they display not only spin-density-wave and superconducting ground states, but also local Eu2+ magnetism at a similar temperature scale. Here we review recent experimental progress in determining the complex phase diagrams of europium-based iron pnictides. The conclusions drawn from the observations reach far beyond these model systems. Thus, although europium-based iron pnictides are very peculiar, they provide a unique platform to study the common interplay of structural-nematic, magnetic and electronic effects in high-temperature superconductors.

  15. Understanding the Unique Electronic Properties of Nano Structures Using Photoemission Theory.

    Science.gov (United States)

    Kwon, Soonnam; Choi, Won Kook

    2015-12-04

    Newly emerging experimental techniques such as nano-ARPES are expected to provide an opportunity to measure the electronic properties of nano-materials directly. However, the interpretation of the spectra is not simple because it must consider quantum mechanical effects related to the measurement process itself. Here, we demonstrate a novel approach that can overcome this problem by using an adequate simulation to corroborate the experimental results. Ab initio calculation on arbitrarily-shaped or chemically ornamented nano-structures is elaborately correlated to photoemission theory. This correlation can be directly exploited to interpret the experimental results. To test this method, a direct comparison was made between the calculation results and experimental results on highly-oriented pyrolytic graphite (HOPG). As a general extension, the unique electronic structures of nano-sized graphene oxide and features from the experimental result of black phosphorous (BP) are disclosed for the first time as supportive evidence of the usefulness of this method. This work pioneers an approach to intuitive and practical understanding of the electronic properties of nano-materials.

  16. A Negative Order Generalized WKI Hierarchy, Bi-Hamiltonian Structure,and Darboux Transformation%一个广义 WKI 谱的负梯队,双哈密顿结构和达布变换

    Institute of Scientific and Technical Information of China (English)

    扎其劳

    2014-01-01

    A new negative order generalized WKI hierarchy is presented.It contains some well known coupled integrable dispersionless systems as special members.Based on the trace identity approach,bi-Hamiltonian struc-ture of the negative order generalized WKI hierarchy is proposed.With the aid of the Darboux matrix method and symbolic computation,a Darboux transformation for this soliton hierarchy is established.%给出一个广义 WKI 谱的负梯队,其中包含了一些已知的无色散可积系统。基于迹恒等式,构造了该负孤子梯队的广义双哈密顿结构。应用达布阵方法和符号计算技巧,建立了该负孤子梯队的达布变换。

  17. 朱载堉才是“需求层次理论”的鼻祖--且更独特,更显棋高一着%It States that It was the Chinese Scientist Zhu Zai Yu in Ming Dynasty that Firstly PutForward the Hierarchy Theory of Needs---Which was Superior and More Unique

    Institute of Scientific and Technical Information of China (English)

    习小林

    2014-01-01

    Academics in the past consider the American psychologist Abraham Maslow as the founder of the hierarchy theory of needs. However,the latest study results from the author have overthrown such kind of biases.It states that it was the chinese scientist Zhu Zai Yu in Ming dynasty that firstly put forward the hierarchy theory of needs which was about 360 years as earlier as Maslow.Also ,the knowledgement from Zhu Zai Yu is suoerior and more unique than that from Maslow.%以往学术界都把美国心理学家马斯洛奉为需求层次理论的鼻祖;但最新的研究成果,彻底推翻了这一陈见,认为中国明朝的科学家朱载堉才是需求层次理论的鼻祖,比美国人马斯洛还要早约三百六十多年,且朱载堉对需求层次的认知,要比马斯洛更独特,更显棋高一着。

  18. Unique Structural and Nucleotide Exchange Features of the Rho1 GTPase of Entamoeba histolytica*

    Science.gov (United States)

    Bosch, Dustin E.; Wittchen, Erika S.; Qiu, Connie; Burridge, Keith; Siderovski, David P.

    2011-01-01

    The single-celled human parasite Entamoeba histolytica possesses a dynamic actin cytoskeleton vital for its intestinal and systemic pathogenicity. The E. histolytica genome encodes several Rho family GTPases known to regulate cytoskeletal dynamics. EhRho1, the first family member identified, was reported to be insensitive to the Rho GTPase-specific Clostridium botulinum C3 exoenzyme, raising the possibility that it may be a misclassified Ras family member. Here, we report the crystal structures of EhRho1 in both active and inactive states. EhRho1 is activated by a conserved switch mechanism, but diverges from mammalian Rho GTPases in lacking a signature Rho insert helix. EhRho1 engages a homolog of mDia, EhFormin1, suggesting a role in mediating serum-stimulated actin reorganization and microtubule formation during mitosis. EhRho1, but not a constitutively active mutant, interacts with a newly identified EhRhoGDI in a prenylation-dependent manner. Furthermore, constitutively active EhRho1 induces actin stress fiber formation in mammalian fibroblasts, thereby identifying it as a functional Rho family GTPase. EhRho1 exhibits a fast rate of nucleotide exchange relative to mammalian Rho GTPases due to a distinctive switch one isoleucine residue reminiscent of the constitutively active F28L mutation in human Cdc42, which for the latter protein, is sufficient for cellular transformation. Nonconserved, nucleotide-interacting residues within EhRho1, revealed by the crystal structure models, were observed to contribute a moderating influence on fast spontaneous nucleotide exchange. Collectively, these observations indicate that EhRho1 is a bona fide member of the Rho GTPase family, albeit with unique structural and functional aspects compared with mammalian Rho GTPases. PMID:21930699

  19. Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.

    Science.gov (United States)

    Bosch, Dustin E; Wittchen, Erika S; Qiu, Connie; Burridge, Keith; Siderovski, David P

    2011-11-11

    The single-celled human parasite Entamoeba histolytica possesses a dynamic actin cytoskeleton vital for its intestinal and systemic pathogenicity. The E. histolytica genome encodes several Rho family GTPases known to regulate cytoskeletal dynamics. EhRho1, the first family member identified, was reported to be insensitive to the Rho GTPase-specific Clostridium botulinum C3 exoenzyme, raising the possibility that it may be a misclassified Ras family member. Here, we report the crystal structures of EhRho1 in both active and inactive states. EhRho1 is activated by a conserved switch mechanism, but diverges from mammalian Rho GTPases in lacking a signature Rho insert helix. EhRho1 engages a homolog of mDia, EhFormin1, suggesting a role in mediating serum-stimulated actin reorganization and microtubule formation during mitosis. EhRho1, but not a constitutively active mutant, interacts with a newly identified EhRhoGDI in a prenylation-dependent manner. Furthermore, constitutively active EhRho1 induces actin stress fiber formation in mammalian fibroblasts, thereby identifying it as a functional Rho family GTPase. EhRho1 exhibits a fast rate of nucleotide exchange relative to mammalian Rho GTPases due to a distinctive switch one isoleucine residue reminiscent of the constitutively active F28L mutation in human Cdc42, which for the latter protein, is sufficient for cellular transformation. Nonconserved, nucleotide-interacting residues within EhRho1, revealed by the crystal structure models, were observed to contribute a moderating influence on fast spontaneous nucleotide exchange. Collectively, these observations indicate that EhRho1 is a bona fide member of the Rho GTPase family, albeit with unique structural and functional aspects compared with mammalian Rho GTPases.

  20. Unique Structural and Nucleotide Exchange Features of the Rho1 GTPase of Entamoeba histolytica

    Energy Technology Data Exchange (ETDEWEB)

    Bosch, Dustin E.; Wittchen, Erika S.; Qiu, Connie; Burridge, Keith; Siderovski, David P. (UNC)

    2012-08-10

    The single-celled human parasite Entamoeba histolytica possesses a dynamic actin cytoskeleton vital for its intestinal and systemic pathogenicity. The E. histolytica genome encodes several Rho family GTPases known to regulate cytoskeletal dynamics. EhRho1, the first family member identified, was reported to be insensitive to the Rho GTPase-specific Clostridium botulinum C3 exoenzyme, raising the possibility that it may be a misclassified Ras family member. Here, we report the crystal structures of EhRho1 in both active and inactive states. EhRho1 is activated by a conserved switch mechanism, but diverges from mammalian Rho GTPases in lacking a signature Rho insert helix. EhRho1 engages a homolog of mDia, EhFormin1, suggesting a role in mediating serum-stimulated actin reorganization and microtubule formation during mitosis. EhRho1, but not a constitutively active mutant, interacts with a newly identified EhRhoGDI in a prenylation-dependent manner. Furthermore, constitutively active EhRho1 induces actin stress fiber formation in mammalian fibroblasts, thereby identifying it as a functional Rho family GTPase. EhRho1 exhibits a fast rate of nucleotide exchange relative to mammalian Rho GTPases due to a distinctive switch one isoleucine residue reminiscent of the constitutively active F28L mutation in human Cdc42, which for the latter protein, is sufficient for cellular transformation. Nonconserved, nucleotide-interacting residues within EhRho1, revealed by the crystal structure models, were observed to contribute a moderating influence on fast spontaneous nucleotide exchange. Collectively, these observations indicate that EhRho1 is a bona fide member of the Rho GTPase family, albeit with unique structural and functional aspects compared with mammalian Rho GTPases.

  1. Hierarchy of knowledge in GIS

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    An intelligent geographic information system (GIS) has to handle various types and huge volumes of geoscience-related knowledge as well as enormous amounts of data and information. More recent attention concentrates on collection,represen-tation,management,and usage of knowledge. This article presents a three-tier hi-erarchy for geoscience knowledge in a GIS. The first tier is for knowledge of data. It includes knowledge of feature objects definition,data structure,data model,and relations among data as well as rules,restrictions,and regulations about data. The second tier is for knowledge of processing. It describes analysis models,data processing procedures,workflows,and conditions. The third tier contains knowl-edge of a GIS for the public sector. This tier provides knowledge to people on how to access this GIS and what the GIS can do. The three-tier hierarchy of knowledge in a GIS provides an understandable and practical category frame to handle geo-science knowledge. One of the advantages of this hierarchy is that it separates system resource consumption into different stages so it can avoid exhausting the system at peak times when the GIS handles a complex,large task.

  2. Genetic structure of a unique admixed population: implications for medical research.

    Science.gov (United States)

    Patterson, Nick; Petersen, Desiree C; van der Ross, Richard E; Sudoyo, Herawati; Glashoff, Richard H; Marzuki, Sangkot; Reich, David; Hayes, Vanessa M

    2010-02-01

    STATEMENT: In naming population groups, we think a chief aim is to use terms that the group members use themselves, or find familiar and comfortable. The terms used in this manuscript to describe populations are as historically correct as possible and are chosen so as not to offend any population group. Two of the authors (DCP and REvdR) belong to the Coloured population, with one of the authors (REvdR) having contributed extensively to current literature on the history of the Coloured people of South Africa and served as Vice-President of the South African Institute of Race Relations. According to the 2001 South African census (http://www.statssa.gov.za/census01/HTML/CInBrief/CIB2001.pdf), "Statistics South Africa continues to classify people by population group, in order to monitor progress in moving away from the apartheid-based discrimination of the past. However, membership of a population group is now based on self-perception and self-classification, not on a legal definition. Five options were provided on the questionnaire, Black African, Coloured, Indian or Asian, White and Other. Responses in the category 'Other' were very few and were therefore imputed". We have elected to use the term Bushmen rather than San to refer to the hunter-gatherer people of Southern Africa. Although they have no collective name for themselves, this decision was based on the term Bushmen (or Bossiesman) being the more familiar to the communities themselves, while the term San is the more accepted academic classification. Understanding human genetic structure has fundamental implications for understanding the evolution and impact of human diseases. In this study, we describe the complex genetic substructure of a unique and recently admixed population arising approximately 350 years ago as a direct result of European settlement in South Africa. Analysis was performed using over 900 000 genome-wide single nucleotide polymorphisms in 20 unrelated ancestry-informative marker selected

  3. Human blood basophils display a unique phenotype including activation linked membrane structures.

    Science.gov (United States)

    Stain, C; Stockinger, H; Scharf, M; Jäger, U; Gössinger, H; Lechner, K; Bettelheim, P

    1987-12-01

    To evaluate the membrane marker profile of human basophils a panel of well-established monoclonal antibodies (MoAbs, n = 60) was used for a combined toluidine/immunofluorescence staining procedure. Myeloid-associated MoAbs (particularly MoAbs against the LFA-1 family (CD11, CDw18), MoAbs directed against lactosylceramide (CDw17), anti-glycoprotein (gp) 150 MoAbs MCS 2 and MY 7 (CDw13), anti-gp 67 MoAb MY 9, anti Fc gamma-receptor (mol wt 40 kd) MoAb CIKM5, anti-CR 1 MoAb E 11, and the antiglycolipid MoAb VIM-2) were reactive with basophils, indicating a close relationship to other mature myeloid cells. Under normal conditions, basophils surprisingly express at least three activation-linked structures not detectable on mature neutrophils, ie, the p45 structure defined by MoAbs OKT-10 and VIP-2b, the p24 structure identified by the CD9 MoAb BA-2, and the receptor for interleukin 2 (IL 2) recognized by three different MoAbs (anti-TAC, IL2RI, anti-IL 2). Moreover, under short-term culture conditions basophils both in mononuclear cell (MNC) suspension and as purified fractions display the HLA-DR and T4 antigens. The neutrophilic/eosinophilic structure 3-fucosyl-N-acetyllactosamine is expressed on basophils only after neuraminidase treatment. Basophils were not stained at all by CD 16 MoAbs directed against the Fc gamma-receptor (mol wt 50 to 70 kd) of neutrophils, by the MoAb 63D3 (CDw12) recognizing the monocyte/granulocyte-associated p 200 antigen, and by the CDw 14 antibodies (VIM-13, Mo 2) defining the monocyte-specific structure p 55. Enriched basophils freshly obtained from chronic granulocytic leukemia (CGL) patients yielded identical results in FACS analyses. In summary, these data indicate that basophils generate a unique combination of surface determinants and possibly represent an activated cell population.

  4. Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist.

    Science.gov (United States)

    McCurdy, Christopher R; Sufka, Kenneth J; Smith, Grant H; Warnick, Jason E; Nieto, Marcelo J

    2006-01-01

    Salvinorin A, is a structurally unique, non-nitrogenous, kappa opioid receptor (KOP) agonist. Given the role of KOPs in analgesic processes, we set out to determine whether salvinorin A has antinociceptive activity in thermal and chemo-nociceptive assays. The tail-flick assay was employed to investigate 1) salvinorin A's (0.5, 1.0, 2.0, and 4.0 mg/kg) dose-response and time-course (10, 20, and 30 min) effects in a thermal nociceptive assay, and 2) the ability for the KOP antagonist norBNI (10.0 mg/kg) to prevent salvinorin A antinociception. The hotplate assay was utilized as a second thermal nociceptive measure to test salvinorin A's dose-response effects. The acetic acid abdominal constriction assay was used to study salvinorin A's dose-response and time-course (over 30 min) effects in a chemo-nociceptive assay. Together, these studies revealed that salvinorin A produces a dose-dependent antinociception that peaked at 10 min post-injection but rapidly returned to baseline. Additionally, pretreatment with the KOP antagonist norbinaltorphimine (norBNI) reversed salvinorin A-induced antinociception. These findings demonstrate that salvinorin A produces a KOP mediated antinociceptive effect with a short duration of action.

  5. Rethinking the waste hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, C.; Vigsoe, D. (eds.)

    2005-03-01

    There is an increasing need to couple environmental and economic considerations within waste management. Consumers and companies alike generate ever more waste. The waste-policy challenges of the future lie in decoupling growth in waste generation from growth in consumption, and in setting priorities for the waste management. This report discusses the criteria for deciding priorities for waste management methods, and questions the current principles of EU waste policies. The basis for the discussion is the so-called waste hierarchy which has dominated the waste policy in the EU since the mid-1970s. The waste hierarchy ranks possible methods of waste management. According to the waste hierarchy, the very best solution is to reduce the amount of waste. After that, reuse is preferred to recycling which, in turn, is preferred to incineration. Disposal at a landfill is the least favourable solution. (BA)

  6. Extracting tag hierarchies

    CERN Document Server

    Tibély, Gergely; Vicsek, Tamás; Palla, Gergely

    2014-01-01

    Tagging items with descriptive annotations or keywords is a very natural way to compress and highlight information about the properties of the given entity. Over the years several methods have been proposed for extracting a hierarchy between the tags for systems with a "flat", egalitarian organization of the tags, which is very common when the tags correspond to free words given by numerous independent people. Here we present a complete framework for automated tag hierarchy extraction based on tag occurrence statistics. Along with proposing new algorithms, we are also introducing different quality measures enabling the detailed comparison of competing approaches from different aspects. Furthermore, we set up a synthetic, computer generated benchmark providing a versatile tool for testing, with a couple of tunable parameters capable of generating a wide range of test beds. Beside the computer generated input we also use real data in our studies, including a biological example with a pre-defined hierarchy betwe...

  7. Hierarchy effect on electronic structure and core-to-valence transitions in bone tissue: perspectives in medical nanodiagnostics of mineralized bone

    Science.gov (United States)

    Samoilenko, Dmitrii O.; Avrunin, Alexander S.; Pavlychev, Andrey A.

    2017-06-01

    Electronic structure and core-to-valence transitions in bone tissue are examined in the framework of the morphological 3DSL model that takes into account (i) structural and functional organization of the skeleton in the normal and pathological conditions and (ii) peculiarities of electron wave propagation in a three-dimensional superlattice of "black-nanocrystallites-in-muddy-waters". Our focus is on the HAP-to-bone red shifts of core-to-valence transitions near Ca and P 2p and O 1s edges in single-crystal hydroxyapatite (HAP) Ca10(PO4)6(OH)2. The origin of the HAP-to-bone shift is discussed and the extended comparative analysis of the experimental data is performed. The detected spectral shift is assigned with the effect of hierarchical organization of bone tissue. This hierarchy effect on the core-to-valence transition energies is regarded as a promising tool for medical imaging and perspective pathway for nanodiagnostics of mineralized bone. Contribution to the Topical Issue "Dynamics of Systems at the Nanoscale", edited by Andrey Solov'yov and Andrei Korol.

  8. When Do Types Induce the Same Belief Hierarchy?

    Directory of Open Access Journals (Sweden)

    Andrés Perea

    2016-10-01

    Full Text Available Type structures are a simple device to describe higher-order beliefs. However, how can we check whether two types generate the same belief hierarchy? This paper generalizes the concept of a type morphism and shows that one type structure is contained in another if and only if the former can be mapped into the other using a generalized type morphism. Hence, every generalized type morphism is a hierarchy morphism and vice versa. Importantly, generalized type morphisms do not make reference to belief hierarchies. We use our results to characterize the conditions under which types generate the same belief hierarchy.

  9. Hierarchies in student groups

    OpenAIRE

    Güntert, Manuel

    2008-01-01

    This is a research about hierarchies in student groups. It shows how they are built und what sense they have. The position of a student in his student peer group is evaluated. The influence of the look, the style, the behaviour of the other sex, the gender, the origin, the prehistory, the appearance, achievement and their effect on hierarchies is analysed and the impact of charisma and organisation are compared. The meaning of this research is to indicate how a student must be to get the lead...

  10. SPATIAL HIERARCHY AND INTERFACIAL STRUCTURE IN INJECTION-MOLDED BARS OF POLYPROPYLENE-BASED BLENDS AND COMPOSITES

    Institute of Scientific and Technical Information of China (English)

    Ke Wang; Min Guo; Si Liang; Ping Zhao; Hong Yang; Qin Zhang; Rong-ni Du; Qiang Fu

    2007-01-01

    The hierarchical structure and interfacial morphology of injection-molded bars of polypropylene (PP) based blends and composites have been investigated in detail from the skin to the core. For preparation of injection-molded bars with high-level orientation and good interfacial adhesion, a dynamic packing injection molding technology was applied to exert oscillatory shear on the melts during solidification stage. Depending on incorporated component, interfacial adhesion and processing conditions, various oriented structure and morphology could be obtained. First, we will elucidate the epitaxial behavior between PP and high-density polyethylene occurring in practical molded processing. Then, the shear-induced transcrystalline structure will be the main focus for PP/fiber composites. At last, various oriented clay structures have been ascertained unambiguously in PP/organoclay nanocomposites along the thickness of molded bars.

  11. A Second Look at Maslow's Hierarchy of Basic Needs.

    Science.gov (United States)

    White, Charles M.

    Implications of Maslow's Need Hierarchy are considered in this paper, along with possible qualifications to the suggested structure and potential effects of superimposing relative deprivation theory onto the hierarchy as an approach to adult education. The interfacing of needs and alternative structurings is discussed in terms of two theories: (1)…

  12. A Second Look at Maslow's Hierarchy of Basic Needs.

    Science.gov (United States)

    White, Charles M.

    Implications of Maslow's Need Hierarchy are considered in this paper, along with possible qualifications to the suggested structure and potential effects of superimposing relative deprivation theory onto the hierarchy as an approach to adult education. The interfacing of needs and alternative structurings is discussed in terms of two theories: (1)…

  13. The network motif architecture of dominance hierarchies.

    Science.gov (United States)

    Shizuka, Daizaburo; McDonald, David B

    2015-04-01

    The widespread existence of dominance hierarchies has been a central puzzle in social evolution, yet we lack a framework for synthesizing the vast empirical data on hierarchy structure in animal groups. We applied network motif analysis to compare the structures of dominance networks from data published over the past 80 years. Overall patterns of dominance relations, including some aspects of non-interactions, were strikingly similar across disparate group types. For example, nearly all groups exhibited high frequencies of transitive triads, whereas cycles were very rare. Moreover, pass-along triads were rare, and double-dominant triads were common in most groups. These patterns did not vary in any systematic way across taxa, study settings (captive or wild) or group size. Two factors significantly affected network motif structure: the proportion of dyads that were observed to interact and the interaction rates of the top-ranked individuals. Thus, study design (i.e. how many interactions were observed) and the behaviour of key individuals in the group could explain much of the variations we see in social hierarchies across animals. Our findings confirm the ubiquity of dominance hierarchies across all animal systems, and demonstrate that network analysis provides new avenues for comparative analyses of social hierarchies.

  14. The Reinforcement Hierarchy

    Science.gov (United States)

    Forness, Steven R.

    1973-01-01

    Reinforcement hierarchy implies movement along a continuum from top to bottom, from primitive levels of reinforcement to more sophisticated levels. Unless it is immediately obvious that a child cannot function without the use of lower-order reinforcers, we should approach him as though he responds to topmost reinforcers until he demonstrates…

  15. Theory of uniqueness of Indian Caste System

    Directory of Open Access Journals (Sweden)

    Ashwin Kumar

    2006-08-01

    Full Text Available Classical studies on pre-modern Indian social structure have suggested apparent differences between the Indian caste system and social stratification as one can discern in other parts of the world. However, one needs to question such dogmatic assertions that such vast differences really existed. An endeavor is made in this research paper to reflect on the nature of caste hierarchy in pre-modern India. The caste system forms the significant basis of pre-modern Indian social structure. Early writers conceived the caste system of pre-modern India as something unique to India. An attempt is made to question this application of theory of uniqueness in the case of India.

  16. Theory of uniqueness of Indian Caste System

    Directory of Open Access Journals (Sweden)

    Ashwin Kumar

    2005-11-01

    Full Text Available Classical studies on pre-modern Indian social structure have suggested apparent differences between the Indian caste system and social stratification as one can discern in other parts of the world. However, one needs to question such dogmatic assertions that such vast differences really existed. An endeavor is made in this research paper to reflect on the nature of caste hierarchy in pre-modern India. The caste system forms the significant basis of pre-modern Indian social structure. Early writers conceived the caste system of pre-modern India as something unique to India. An attempt is made to question this application of theory of uniqueness in the case of India.

  17. Detecting the Neutrinos Mass Hierarchy from Cosmological Data

    CERN Document Server

    Xu, Lixin

    2016-01-01

    We propose a new parameterization to measure the neutrino mass hierarchy, namely $\\Delta=(m_3-m_1)/(m_1+m_3)$ which is dimensionless and varies in the range $[-1,1]$. Taking into account the results of neutrino oscillation experiments, $\\Delta$ is the unique parameter for determining all the masses of neutrinos, and a positive (negative) sign of $\\Delta$ denotes the normal (inverted) mass hierarchy. Adopting the currently available cosmic observations, we find that the normal mass hierarchy is slightly favored, and the mass of lightest neutrino is less than $0.030$ eV for the normal mass hierarchy and $0.024$ eV for the inverted mass hierarchy at $95\\%$ confidence level.

  18. Non-Fourier thermal transport induced structural hierarchy and damage to collagen ultrastructure subjected to laser irradiation.

    Science.gov (United States)

    Sahoo, Nilamani; Narasimhan, Arunn; Dhar, Purbarun; Das, Sarit K

    2017-07-09

    Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nanospheres have been synthesised and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region. Thermal history was observed experimentally and simulated considering non-Fourier dual phase lag (DPL) model incorporated Pennes bio-heat transfer equation using COMSOL Multiphysics software. The gross deviation in temperature i.e. rise from the classical Fourier model for bio-heat conduction suggests additional effects of temperature rise on the secondary structures and morphological and physico-chemical changes to the collagen ultrastructures building the tissue mass. The observed thermal denaturation in the collagen fibril morphologies have been explained based on the physico-chemical structure of collagen and its response to thermal radiation. The large shift in frequency of amides A and B is pronounced at a depth of maximum temperature rise compared with other positions in tissue phantom. Observations for change in band of amide I, amide II, and amide III are found to be responsible for damage to collagen ultra-structure. Variation in the concentration of gold nanostructures shows the potentiality of localised hyperthermia treatment subjected to NIR radiation through a proposed free radical mechanism.

  19. An extension of heat hierarchy

    OpenAIRE

    Wang, Joe S.

    2014-01-01

    We propose a formally completely integrable extension of heat hierarchy based on the space of symmetries isomorphic to the Weyl algebra $\\mathcal{A}_1$. The extended heat hierarchy will be the basic model for the analysis of the extension of KP hierarchy, and other integrable equations.

  20. Structural characterization and antioxidative activity of lancifonins: unique nortriterpenoids from Schisandra lancifolia.

    Science.gov (United States)

    Shi, Yi-Ming; Yang, Jie; Xu, Li; Li, Xiao-Nian; Shang, Shan-Zhai; Cao, Peng; Xiao, Wei-Lie; Sun, Han-Dong

    2014-03-01

    Six unique nortriterpenoids, lancifonins A-F (1-6), were isolated from Schisandra lancifolia. Their absolute configurations were determined by X-ray diffraction and ECD calculation. The conformational analysis of 1 was performed due to the unanticipated changes of Cotton effects in its ECD spectrum. Compounds 5 and 6 possess a unique 7/7 fused carbocyclic core with an internal ester bridge between C-9 and C-14, and 5 exhibited protective activity against H2O2-induced oxidative damage on Caco-2 cells.

  1. A hierarchy of Poisson brackets

    CERN Document Server

    Pavelka, Michal; Esen, Ogul; Grmela, Miroslav

    2015-01-01

    The vector field generating reversible time evolution of macroscopic systems involves two ingredients: gradient of a potential (a covector) and a degenerate Poisson structure transforming the covector into a vector. The Poisson structure is conveniently expressed in Poisson brackets, its degeneracy in their Casimirs (i.e. potentials whose gradients produce no vector field). In this paper we investigate in detail hierarchies of Poisson brackets, together with their Casimirs, that arise in passages from more to less detailed (i.e. more macroscopic) descriptions. In particular, we investigate the passage from mechanics of particles (in its Liouville representation) to the reversible kinetic theory and the passage from the reversible kinetic theory to the reversible fluid mechanics. From the physical point of view, the investigation includes binary mixtures and two-point formulations suitable for describing turbulent flows. From the mathematical point of view, we reveal the Lie algebra structure involved in the p...

  2. Disasters, the media and social structures: a typology of credibility hierarchy persistence based on a newspaper coverage of the Love Canal and six other disasters.

    Science.gov (United States)

    Ploughman, P

    1997-06-01

    The starting-point of this paper is the assumption that credibility and the right to be heard are differentially distributed in any social system and therefore a 'hierarchy of credibility' exists. To test this, the media coverage of the Love Canal, New York, hazardous waste landfill disaster and six other disasters was examined to determine if this hierarchy exists in all cases. A hierarchy of credibility emphasising the views of established news sources with routine and habitual access to the media was demonstrated in the majority of events examined However, the Love Canal disaster was one of two where this hierarchy was disrupted due to a number of factors. These included the contentious or political nature of the event, its duration, the extent of competition of credibility and coverage among news sources, the extent of information shortage, the type of news medium, the degree of sympathetic and representational salience of victims and the extent to which they organized and achieved status as 'newsmakers'. Building on disaster research, a model of the operation of the credibility hierarchy in coverage of disasters is presented and discussed.

  3. A Hierarchy of New Nonlinear Evolution Equations Associated with a 3 × 3 Matrix Spectral Problem

    Institute of Scientific and Technical Information of China (English)

    GENG Xian-Guo; LI Fang

    2009-01-01

    A 3 × 3 matrix spectral problem with three potentials and the corresponding hierarchy of new nonlinear evolution equations are proposed. Generalized Hamiltonian structures for the hierarchy of nonlinear evolution equations are derived with the aid of trace identity.

  4. Hierarchies in Dependence Logic

    CERN Document Server

    Durand, Arnaud

    2011-01-01

    We study fragments of dependence logic defined either by restricting the number k of universal quantifiers or the width of dependence atoms in formulas. We find the sublogics of existential second-order logic corresponding to these fragments of dependence logic. We also show that these both ways of defining fragments of dependence logic give rise to a hierarchy in expressive power with respect to k.

  5. THE HAMILTONIAN SYSTEMS OF THE LCZ HIERARCHY BY NONLINEARIZATION

    Institute of Scientific and Technical Information of China (English)

    Li Lu

    2000-01-01

    In this paper, we first search for the Hamiltonian structure of LCZ hierarchy by use of a trace identity. Then we determine a higher-order constraint condition between the potentials and the eigenfunctions of the LCZ spectral problem, and under this constraint condition, the Lax pairs of LCZ hierarchy are all nonlinearized into the finite-dimensional integrable Hamiltonian systems in Liouville sense.

  6. Nonlinear Super Integrable Couplings of Super Classical-Boussinesq Hierarchy

    Directory of Open Access Journals (Sweden)

    Xiuzhi Xing

    2014-01-01

    Full Text Available Nonlinear integrable couplings of super classical-Boussinesq hierarchy based upon an enlarged matrix Lie super algebra were constructed. Then, its super Hamiltonian structures were established by using super trace identity. As its reduction, nonlinear integrable couplings of the classical integrable hierarchy were obtained.

  7. An Operational Investigation of the CPS Hierarchy

    DEFF Research Database (Denmark)

    Danvy, Olivier; Yang, Zhe

    1998-01-01

    We explore the hierarchy of control induced by successive transformations into continuation-passing style (CPS) in the presence of “control delimiters ” and “composable continuations ”. Specifically, we investigate the structural operational semantics associated with the CPS hierarchy. To this end......, we characterize an operational notion of continuation semantics. We relate it to the traditional CPS transformation and we use it to account for the control operator shift and the control delimiter reset operationally. We then transcribe the resulting continuation semantics in ML, thus obtaining...

  8. A unique structure for the multiplexer in quantum-dot cellular automata to create a revolution in design of nanostructures

    Energy Technology Data Exchange (ETDEWEB)

    Naji Asfestani, Mazaher; Rasouli Heikalabad, Saeed, E-mail: s.rasouli@iaut.ac.ir

    2017-05-01

    Quantum-dot cellular automata (QCA) is the advent of technology and suitable replacement for semiconductor transistor technology. In this paper, a unique structure for the 2:1 multiplexer is presented in QCA. The structure of this component is simple, ultra-efficient and very useful to implement the various logical functions. The proposed structure does not follow any Boolean function. It takes advantage of the inherent characteristics of quantum technology to produce the desired output. Based on these principles, we design the new and efficient structures for the 4:1 multiplexer and 8:1 multiplexer in the QCA technology. These structures are designed with QCADesigner simulator and simulation results are examined. Investigation results indicate the amazing performance of proposed structure compared to existing structures in terms of area, complexity, power consumption and latency.

  9. 社区结构下的刚性分层与柔性治理%Rigid Hierarchy and Flexible Governance under the Community Structure

    Institute of Scientific and Technical Information of China (English)

    范和生; 许君

    2015-01-01

    From the perspective of structure-function,the governance ways of Tongling new village commu-nity which is in marginal position social resources to the disadvantaged in the area are mainly reflected in two aspects .From the aspect of system ,Tongling new village community′s governance adopts rigid hierar-chical system in strict accordance with the state administrative system to improve the community′s unity, efficiency and authority .In the specific service program , Tongling new village community′s governance emphases on flexible governance which is on the basis of interpersonal relationships and humanistic care to perform functions of the community′s comprehensive governance ,diverse governance and human nature governance .The combination of rigid hierarchy and flexible governance makes the community a benign in-teraction platform between the government and residents in the role of "connection".%从结构-功能的视角来看,社会资源处于边际地位的铜陵新村社区对辖区弱势群体的治理方式,表现为制度上严格按照国家行政体制刚性分层,提高社区的统一性、效率性和权威性;在具体的服务程序中,则偏重人际关系和人文关怀基础上的柔性治理,履行社区综合治理、多元治理和人性治理职能。刚性分层与柔性治理的结合使社区在“承上启下”的角色中成为政府与居民之间良性互动的平台。

  10. Singular sector of the Burgers-Hopf hierarchy and deformations of hyperelliptic curves

    Energy Technology Data Exchange (ETDEWEB)

    Kodama, Yuji [Department of Mathematics, Ohio State University, Columbus, OH (United States)]. E-mail: kodama@math.ohio-state.edu; Konopelchenko, Boris G. [Dipartimento di Fisica, Universita di Lecce and Sezione INFN, Lecce (Italy)]. E-mail: konopel@le.infn.it

    2002-08-09

    We discuss the structure of shock singularities of the Burgers-Hopf hierarchy. It is shown that the set of singular solutions defines a stratification of the affine space of the flow parameters in the hierarchy. The stratification is associated with the Birkhoff decomposition of the Grassmannian given by the set of linear spaces spanned by the hierarchy. We then construct integrable hierarchy on each stratum and demonstrate that it describes a deformation of a hyperelliptic curve parametrizing the stratum. The hierarchy is called the hidden Burgers-Hopf hierarchy, and we found the Riemann invariant form and the hodograph solution. (author)

  11. Block algebra in two-component BKP and D type Drinfeld-Sokolov hierarchies

    Science.gov (United States)

    Li, Chuanzhong; He, Jingsong

    2013-11-01

    We construct generalized additional symmetries of a two-component BKP hierarchy defined by two pseudo-differential Lax operators. These additional symmetry flows form a Block type algebra with some modified (or additional) terms because of a B type reduction condition of this integrable hierarchy. Further we show that the D type Drinfeld-Sokolov hierarchy, which is a reduction of the two-component BKP hierarchy, possess a complete Block type additional symmetry algebra. That D type Drinfeld-Sokolov hierarchy has a similar algebraic structure as the bigraded Toda hierarchy which is a differential-discrete integrable system.

  12. Block algebra in two-component BKP and D type Drinfeld-Sokolov hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Li, Chuanzhong, E-mail: lichuanzhong@nbu.edu.cn; He, Jingsong, E-mail: hejingsong@nbu.edu.cn [Department of Mathematics, Ningbo University, Ningbo 315211 (China)

    2013-11-15

    We construct generalized additional symmetries of a two-component BKP hierarchy defined by two pseudo-differential Lax operators. These additional symmetry flows form a Block type algebra with some modified (or additional) terms because of a B type reduction condition of this integrable hierarchy. Further we show that the D type Drinfeld-Sokolov hierarchy, which is a reduction of the two-component BKP hierarchy, possess a complete Block type additional symmetry algebra. That D type Drinfeld-Sokolov hierarchy has a similar algebraic structure as the bigraded Toda hierarchy which is a differential-discrete integrable system.

  13. Unique Reversible Crystal-to-Crystal Phase Transition – Structural and Functional Properties of Fused Ladder Thienoarenes

    KAUST Repository

    Abe, Yuichiro

    2017-08-15

    Donor-acceptor type molecules based on fused ladder thienoarenes, indacenodithiophene (IDT) and dithienocyclopenta-thienothiophene (DTCTT), coupled with benzothiadiazole, are prepared and their solid-state structures are investigated. They display a rich variety of solid phases ranging from amorphous glass states to crystalline states, upon changes in the central aromatic core and side group structures. Most notably, the DTCTT-based derivatives showed reversible crystal-to-crystal phase transitions in heating and cooling cycles. Unlike what has been seen in π−conjugated molecules variable temperature XRD revealed that structural change occurs continuously during the transition. A columnar self-assembled structure with slip-stacked π−π interaction is proposed to be involved in the solid-state. This research provides the evidence of unique structural behavior of the DTCTT-based molecules through the detailed structural analysis. This unique structural transition paves the way for these materials to have self-healing of crystal defects, leading to improved optoelectronic properties.

  14. Unique Gene-Silencing and Structural Properties of 2;#8242;-Fluoro-Modified siRNAs

    Energy Technology Data Exchange (ETDEWEB)

    Manoharan, Muthiah; Akinc, Akin; Pandey, Rajendra K.; Qin, June; Hadwiger, Philipp; John, Matthias; Mills, Kathy; Charisse, Klaus; Maier, Martin A.; Nechev, Lubomir; Greene, Emily M.; Pallan, Pradeep S.; Rozners, Eriks; Rajeev, Kallanthottathil G.; Egli, Martin (Binghamton); (Alnylam Pharm.); (Vanderbilt)

    2015-10-15

    With little or no negative impact on the activity of small interfering RNAs (siRNAs), regardless of the number of modifications or the positions within the strand, the 2'-deoxy-2'-fluoro (2'-F) modification is unique. Furthermore, the 2'-F-modified siRNA (see crystal structure) was thermodynamically more stable and more nuclease-resistant than the parent siRNA, and produced no immunostimulatory response.

  15. Nuclear Resonance Scattering of Synchrotron Radiation as a Unique Electronic, Structural, and Thermodynamic Probe

    Science.gov (United States)

    Alp, E. Ercan; Sturhahn, Wolfgang; Toellner, Thomas S.; Zhao, Jiyong; Leu, Bogdan M.

    Discovery of Mössbauer effect [1] in a nuclear transition was a remarkable development. It revealed how long-lived nuclear states with relatively low energies in the kiloelectron volt (keV) region can be excited without recoil. This new effect had a unique feature involving a coupling between nuclear physics and solid-state physics, both in terms of physics and sociology. Physics coupling originates from the fact that recoilless emission and absorption or resonance is only possible if the requirement that nuclei have to be bound in a lattice with quantized vibrational states is fulfilled, and that the finite electron density on the nucleus couples to nuclear degrees of freedom leading to hyperfine interactions. Thus, Mössbauer spectroscopy allows peering into solid-state effects using unique nuclear transitions. Sociological aspects of this coupling had been equally startling and fruitful. The interaction between diverse scientific communities, who learned to use Mössbauer spectroscopy proved to be very valuable. For example, biologists, geologists, chemists, physicists, materials scientists, and archeologists, all sharing a common spectroscopic technique, also learned to appreciate the beauty and intricacies of each other's fields. As a laboratory-based technique, Mössbauer spectroscopy matured by the end of the 1970s. Further exciting developments took place when accelerator-based techniques were employed, like synchrotron radiation or "in-beam" Mössbauer experiments with implanted radioactive ions. More recently, two Mössbauer spectrometers on the surface of the Mars kept the technique vibrant and viable up until present time.

  16. Solving moment hierarchies for chemical reaction networks

    Science.gov (United States)

    Krishnamurthy, Supriya; Smith, Eric

    2017-10-01

    The study of chemical reaction networks (CRN’s) is a very active field. Earlier well-known results (Feinberg 1987 Chem. Enc. Sci. 42 2229, Anderson et al 2010 Bull. Math. Biol. 72 1947) identify a topological quantity called deficiency, for any CRN, which, when exactly equal to zero, leads to a unique factorized steady-state for these networks. No results exist however for the steady states of non-zero-deficiency networks. In this paper, we show how to write the full moment-hierarchy for any non-zero-deficiency CRN obeying mass-action kinetics, in terms of equations for the factorial moments. Using these, we can recursively predict values for lower moments from higher moments, reversing the procedure usually used to solve moment hierarchies. We show, for non-trivial examples, that in this manner we can predict any moment of interest, for CRN’s with non-zero deficiency and non-factorizable steady states.

  17. Delegated Contracting and Corporate Hierarchies

    OpenAIRE

    Choe, Chongwoo; Park, In-Uck

    2004-01-01

    In a typical corporate hierarchy, the manager is delegated the authority to make decisions that set directions for the organization, employ subordinates and contract with external suppliers. This paper explains when such delegation of authority can be optimal, using a model of a firm with three parties: the principal, the manager and the worker. In centralization with two two-tier hierarchies, the principal designs contracts for both agents. In delegation with a three-tier hierarchy, the prin...

  18. Validation of a unique concept for a low-cost, lightweight space-deployable antenna structure

    Science.gov (United States)

    Freeland, R. E.; Bilyeu, G. D.; Veal, G. R.

    1993-01-01

    An experiment conducted in the framework of a NASA In-Space Technology Experiments Program based on a concept of inflatable deployable structures is described. The concept utilizes very low inflation pressure to maintain the required geometry on orbit and gravity-induced deflection of the structure precludes any meaningful ground-based demonstrations of functions performance. The experiment is aimed at validating and characterizing the mechanical functional performance of a 14-m-diameter inflatable deployable reflector antenna structure in the orbital operational environment. Results of the experiment are expected to significantly reduce the user risk associated with using large space-deployable antennas by demonstrating the functional performance of a concept that meets the criteria for low-cost, lightweight, and highly reliable space-deployable structures.

  19. Nuclear Magnetic Resonance Structure Shows that the Severe Acute Respiratory Syndrome Coronavirus-Unique Domain Contains a Macrodomain Fold▿

    Science.gov (United States)

    Chatterjee, Amarnath; Johnson, Margaret A.; Serrano, Pedro; Pedrini, Bill; Joseph, Jeremiah S.; Neuman, Benjamin W.; Saikatendu, Kumar; Buchmeier, Michael J.; Kuhn, Peter; Wüthrich, Kurt

    2009-01-01

    The nuclear magnetic resonance (NMR) structure of a central segment of the previously annotated severe acute respiratory syndrome (SARS)-unique domain (SUD-M, for “middle of the SARS-unique domain”) in SARS coronavirus (SARS-CoV) nonstructural protein 3 (nsp3) has been determined. SUD-M(513-651) exhibits a macrodomain fold containing the nsp3 residues 528 to 648, and there is a flexibly extended N-terminal tail with the residues 513 to 527 and a C-terminal flexible tail of residues 649 to 651. As a follow-up to this initial result, we also solved the structure of a construct representing only the globular domain of residues 527 to 651 [SUD-M(527-651)]. NMR chemical shift perturbation experiments showed that SUD-M(527-651) binds single-stranded poly(A) and identified the contact area with this RNA on the protein surface, and electrophoretic mobility shift assays then confirmed that SUD-M has higher affinity for purine bases than for pyrimidine bases. In a further search for clues to the function, we found that SUD-M(527-651) has the closest three-dimensional structure homology with another domain of nsp3, the ADP-ribose-1"-phosphatase nsp3b, although the two proteins share only 5% sequence identity in the homologous sequence regions. SUD-M(527-651) also shows three-dimensional structure homology with several helicases and nucleoside triphosphate-binding proteins, but it does not contain the motifs of catalytic residues found in these structural homologues. The combined results from NMR screening of potential substrates and the structure-based homology studies now form a basis for more focused investigations on the role of the SARS-unique domain in viral infection. PMID:19052085

  20. Hierarchy measure for complex networks

    CERN Document Server

    Mones, Enys; Vicsek, Tamás

    2012-01-01

    Nature, technology and society are full of complexity arising from the intricate web of the interactions among the units of the related systems (e.g., proteins, computers, people). Consequently, one of the most successful recent approaches to capturing the fundamental features of the structure and dynamics of complex systems has been the investigation of the networks associated with the above units (nodes) together with their relations (edges). Most complex systems have an inherently hierarchical organization and, correspondingly, the networks behind them also exhibit hierarchical features. Indeed, several papers have been devoted to describing this essential aspect of networks, however, without resulting in a widely accepted, converging concept concerning the quantitative characterization of the level of their hierarchy. Here we develop an approach and propose a quantity (measure) which is simple enough to be widely applicable, reveals a number of universal features of the organization of real-world networks...

  1. GPU accelerated tandem traversal of blocked bounding volume hierarchy collision detection for multibody dynamics

    DEFF Research Database (Denmark)

    Damkjær, Jesper; Erleben, Kenny

    2009-01-01

    hierarchies. Our approach makes it possible to perform non-convex object versus non-convex object collision on the GPU, using tandem traversals of bounding volume hierarchies. Prior work only supports single traversals on GPUs. We introduce a blocked hierarchy data structure, using imaginary nodes...

  2. Hierarchies of Inefficient Kernelizability

    CERN Document Server

    Hermelin, Danny; Sołtys, Karolina; Wahlström, Magnus; Wu, Xi

    2011-01-01

    The framework of Bodlaender et al. (ICALP 2008) and Fortnow and Santhanam (STOC 2008) allows us to exclude the existence of polynomial kernels for a range of problems under reasonable complexity-theoretical assumptions. However, there are also some issues that are not addressed by this framework, including the existence of Turing kernels such as the "kernelization" of Leaf Out Branching(k) into a disjunction over n instances of size poly(k). Observing that Turing kernels are preserved by polynomial parametric transformations, we define a kernelization hardness hierarchy, akin to the M- and W-hierarchy of ordinary parameterized complexity, by the PPT-closure of problems that seem likely to be fundamentally hard for efficient Turing kernelization. We find that several previously considered problems are complete for our fundamental hardness class, including Min Ones d-SAT(k), Binary NDTM Halting(k), Connected Vertex Cover(k), and Clique(k log n), the clique problem parameterized by k log n.

  3. The tensor hierarchy algebra

    Energy Technology Data Exchange (ETDEWEB)

    Palmkvist, Jakob, E-mail: palmkvist@ihes.fr [Institut des Hautes Etudes Scientifiques, 35 Route de Chartres, FR-91440 Bures-sur-Yvette (France)

    2014-01-15

    We introduce an infinite-dimensional Lie superalgebra which is an extension of the U-duality Lie algebra of maximal supergravity in D dimensions, for 3 ⩽ D ⩽ 7. The level decomposition with respect to the U-duality Lie algebra gives exactly the tensor hierarchy of representations that arises in gauge deformations of the theory described by an embedding tensor, for all positive levels p. We prove that these representations are always contained in those coming from the associated Borcherds-Kac-Moody superalgebra, and we explain why some of the latter representations are not included in the tensor hierarchy. The most remarkable feature of our Lie superalgebra is that it does not admit a triangular decomposition like a (Borcherds-)Kac-Moody (super)algebra. Instead the Hodge duality relations between level p and D − 2 − p extend to negative p, relating the representations at the first two negative levels to the supersymmetry and closure constraints of the embedding tensor.

  4. Classical Affine W-Algebras for gl_N and Associated Integrable Hamiltonian Hierarchies

    Science.gov (United States)

    De Sole, Alberto; Kac, Victor G.; Valeri, Daniele

    2016-11-01

    We apply the new method for constructing integrable Hamiltonian hierarchies of Lax type equations developed in our previous paper to show that all W-algebras W({gl}N, f)} carry such a hierarchy. As an application, we show that all vector constrained KP hierarchies and their matrix generalizations are obtained from these hierarchies by Dirac reduction, which provides the former with a bi-Poisson structure.

  5. Crystal structure of Mox-1, a unique plasmid-mediated class C β-lactamase with hydrolytic activity towards moxalactam.

    Science.gov (United States)

    Oguri, Takuma; Furuyama, Takamitsu; Okuno, Takashi; Ishii, Yoshikazu; Tateda, Kazuhiro; Bonomo, Robert A; Shimizu-Ibuka, Akiko

    2014-07-01

    Mox-1 is a unique plasmid-mediated class C β-lactamase that hydrolyzes penicillins, cephalothin, and the expanded-spectrum cephalosporins cefepime and moxalactam. In order to understand the unique substrate profile of this enzyme, we determined the X-ray crystallographic structure of Mox-1 β-lactamase at a 1.5-Å resolution. The overall structure of Mox-1 β-lactamase resembles that of other AmpC enzymes, with some notable exceptions. First, comparison with other enzymes whose structures have been solved reveals significant differences in the composition of amino acids that make up the hydrogen-bonding network and the position of structural elements in the substrate-binding cavity. Second, the main-chain electron density is not observed in two regions, one containing amino acid residues 214 to 216 positioned in the Ω loop and the other in the N terminus of the B3 β-strand corresponding to amino acid residues 303 to 306. The last two observations suggest that there is significant structural flexibility of these regions, a property which may impact the recognition and binding of substrates in Mox-1. These important differences allow us to propose that the binding of moxalactam in Mox-1 is facilitated by the avoidance of steric clashes, indicating that a substrate-induced conformational change underlies the basis of the hydrolytic profile of Mox-1 β-lactamase.

  6. O'nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3.

    Directory of Open Access Journals (Sweden)

    Kali D Saxton-Shaw

    Full Text Available O'nyong nyong virus (ONNV and Chikungunya virus (CHIKV are two closely related alphaviruses with very different infection patterns in the mosquito, Anopheles gambiae. ONNV is the only alphavirus transmitted by anopheline mosquitoes, but specific molecular determinants of infection of this unique vector specificity remain unidentified. Fifteen distinct chimeric viruses were constructed to evaluate both structural and non-structural regions of the genome and infection patterns were determined through artificial infectious feeds in An. gambiae with each of these chimeras. Only one region, non-structural protein 3 (nsP3, was sufficient to up-regulate infection to rates similar to those seen with parental ONNV. When ONNV non-structural protein 3 (nsP3 replaced nsP3 from CHIKV virus in one of the chimeric viruses, infection rates in An. gambiae went from 0% to 63.5%. No other single gene or viral region addition was able to restore infection rates. Thus, we have shown that a non-structural genome element involved in viral replication is a major element involved in ONNV's unique vector specificity.

  7. O'nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3.

    Science.gov (United States)

    Saxton-Shaw, Kali D; Ledermann, Jeremy P; Borland, Erin M; Stovall, Janae L; Mossel, Eric C; Singh, Amber J; Wilusz, Jeffrey; Powers, Ann M

    2013-01-01

    O'nyong nyong virus (ONNV) and Chikungunya virus (CHIKV) are two closely related alphaviruses with very different infection patterns in the mosquito, Anopheles gambiae. ONNV is the only alphavirus transmitted by anopheline mosquitoes, but specific molecular determinants of infection of this unique vector specificity remain unidentified. Fifteen distinct chimeric viruses were constructed to evaluate both structural and non-structural regions of the genome and infection patterns were determined through artificial infectious feeds in An. gambiae with each of these chimeras. Only one region, non-structural protein 3 (nsP3), was sufficient to up-regulate infection to rates similar to those seen with parental ONNV. When ONNV non-structural protein 3 (nsP3) replaced nsP3 from CHIKV virus in one of the chimeric viruses, infection rates in An. gambiae went from 0% to 63.5%. No other single gene or viral region addition was able to restore infection rates. Thus, we have shown that a non-structural genome element involved in viral replication is a major element involved in ONNV's unique vector specificity.

  8. Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly

    Science.gov (United States)

    Podobnik, Marjetka; Savory, Peter; Rojko, Nejc; Kisovec, Matic; Wood, Neil; Hambley, Richard; Pugh, Jonathan; Wallace, E. Jayne; McNeill, Luke; Bruce, Mark; Liko, Idlir; Allison, Timothy M.; Mehmood, Shahid; Yilmaz, Neval; Kobayashi, Toshihide; Gilbert, Robert J. C.; Robinson, Carol V.; Jayasinghe, Lakmal; Anderluh, Gregor

    2016-05-01

    The invertebrate cytolysin lysenin is a member of the aerolysin family of pore-forming toxins that includes many representatives from pathogenic bacteria. Here we report the crystal structure of the lysenin pore and provide insights into its assembly mechanism. The lysenin pore is assembled from nine monomers via dramatic reorganization of almost half of the monomeric subunit structure leading to a β-barrel pore ~10 nm long and 1.6-2.5 nm wide. The lysenin pore is devoid of additional luminal compartments as commonly found in other toxin pores. Mutagenic analysis and atomic force microscopy imaging, together with these structural insights, suggest a mechanism for pore assembly for lysenin. These insights are relevant to the understanding of pore formation by other aerolysin-like pore-forming toxins, which often represent crucial virulence factors in bacteria.

  9. KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure

    Science.gov (United States)

    Ksiazek, Miroslaw; Mizgalska, Danuta; Eick, Sigrum; Thøgersen, Ida B.; Enghild, Jan J.; Potempa, Jan

    2015-01-01

    Comparative genomics of virulent Tannerella forsythia ATCC 43037 and a close health-associated relative, Tannerella BU063, revealed, in the latter, the absence of an entire array of genes encoding putative secretory proteases that possess a nearly identical C-terminal domain (CTD) that ends with a -Lys-Leu-Ile-Lys-Lys motif. This observation suggests that these proteins, referred to as KLIKK proteases, may function as virulence factors. Re-sequencing of the loci of the KLIKK proteases found only six genes grouped in two clusters. All six genes were expressed by T. forsythia in routine culture conditions, although at different levels. More importantly, a transcript of each gene was detected in gingival crevicular fluid (GCF) from periodontitis sites infected with T. forsythia indicating that the proteases are expressed in vivo. In each protein, a protease domain was flanked by a unique N-terminal profragment and a C-terminal extension ending with the CTD. Partially purified recombinant proteases showed variable levels of proteolytic activity in zymography gels and toward protein substrates, including collagen, gelatin, elastin, and casein. Taken together, these results indicate that the pathogenic strain of T. forsythia secretes active proteases capable of degrading an array of host proteins, which likely represents an important pathogenic feature of this bacterium. PMID:25954253

  10. KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure

    Directory of Open Access Journals (Sweden)

    Miroslaw eKsiazek

    2015-04-01

    Full Text Available Comparative genomics of virulent Tannerella forsythia ATCC 43037 and a close health-associated relative, Tannerella BU063, revealed, in the latter, the absence of an entire array of genes encoding putative secretory proteases that possess a nearly identical C-terminal domain (CTD that ends with a -Lys-Leu-Ile-Lys-Lys motif. This observation suggests that these proteins, referred to as KLIKK proteases, may function as virulence factors. Re-sequencing of the loci of the KLIKK proteases found only six genes grouped in two clusters. All six genes were expressed by T. forsythia in routine culture conditions, although at different levels. More importantly, a transcript of each gene was detected in gingival crevicular fluid (GCF from periodontitis sites infected with T. forsythia indicating that the proteases are expressed in vivo. In each protein, a protease domain was flanked by a unique N-terminal profragment and a C-terminal extension ending with the CTD. Partially purified recombinant proteases showed variable levels of proteolytic activity in zymography gels and toward protein substrates, including collagen, gelatin, elastin, and casein. Taken together, these results indicate that the pathogenic strain of T. forsythia secretes active proteases capable of degrading an array of host proteins, which likely represents an important pathogenic feature of this bacterium.

  11. KLIKK proteases of Tannerella forsythia: putative virulence factors with a unique domain structure.

    Science.gov (United States)

    Ksiazek, Miroslaw; Mizgalska, Danuta; Eick, Sigrum; Thøgersen, Ida B; Enghild, Jan J; Potempa, Jan

    2015-01-01

    Comparative genomics of virulent Tannerella forsythia ATCC 43037 and a close health-associated relative, Tannerella BU063, revealed, in the latter, the absence of an entire array of genes encoding putative secretory proteases that possess a nearly identical C-terminal domain (CTD) that ends with a -Lys-Leu-Ile-Lys-Lys motif. This observation suggests that these proteins, referred to as KLIKK proteases, may function as virulence factors. Re-sequencing of the loci of the KLIKK proteases found only six genes grouped in two clusters. All six genes were expressed by T. forsythia in routine culture conditions, although at different levels. More importantly, a transcript of each gene was detected in gingival crevicular fluid (GCF) from periodontitis sites infected with T. forsythia indicating that the proteases are expressed in vivo. In each protein, a protease domain was flanked by a unique N-terminal profragment and a C-terminal extension ending with the CTD. Partially purified recombinant proteases showed variable levels of proteolytic activity in zymography gels and toward protein substrates, including collagen, gelatin, elastin, and casein. Taken together, these results indicate that the pathogenic strain of T. forsythia secretes active proteases capable of degrading an array of host proteins, which likely represents an important pathogenic feature of this bacterium.

  12. The Appropriateness of Hierarchies (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2010-09-01

    are complex and not easily fit into tidy boxes of absolute truth, as are commonly given preference in science, technology and medicine fields.I believe the focus on quantitative research arose within EBLIP for two reasons: 1 EBL formed within medical librarianship and those librarians identified more closely with the medical model of problem solving, which placed a higher level of trust in quantitative research; and, 2 there was a tide-swell of professional librarians who were tired of seeing our literature dominated by stories of ‚how I did it good‛, and wanted to see more research being published rather than opinion. This led to sometimes strongly worded and simplistic rhetoric noting that some forms of publication were not scientific, in order perhaps to highlight the importance of quality research. Unfortunately, qualitative research was caught up in this wave and projected as not as worthy as quantitative research. This is clearly noted in the levels of evidence hierarchies that became part of the EBLIP doctrine.In both his original published article on the levels of evidence within EBL (2000a, and a subsequent version (2002, Eldredge places qualitative forms of evidence at or near the bottom of the spectrum, although elsewhere he has recognized the role of both quantitative and qualitative research (2000b. The 2002 version of Eldredge’s levels of evidence does put ‚qualitative research‛ at the middle of the continuum for exploration-type questions, but it still seems marginalized, summed up by a single line as if all qualitative research is one; whereas in the other categories, quantitative methods are given granular description. This model has been readily accepted, but there remains a lack of research on why this would work for librarianship. My concern is that the hierarchical structure may have been too easily accepted and taken as truth, marginalizing other forms of research and not referring back to the original research question. It also could

  13. Creating Imaginative Worlds: Unique Details and Structure in Norma Fox Mazer's Young Adult Fiction.

    Science.gov (United States)

    Angel, Ann

    2001-01-01

    Discusses how writer Norma Fox Mazer has helped many readers make the leap between reality and imagination simply in the way she handles details in the lives of her characters. Explores the ideas of communicating with detail, experimenting with structure, and playing with time in crucial scenes. (SG)

  14. CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

    Science.gov (United States)

    Brown, Nicholas R.; Korolchuk, Svitlana; Martin, Mathew P.; Stanley, Will A.; Moukhametzianov, Rouslan; Noble, Martin E. M.; Endicott, Jane A.

    2015-04-01

    CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all eukaryotes. Here we report the crystal structures of complexes of CDK1-Cks1 and CDK1-cyclin B-Cks2. These structures confirm the conserved nature of the inactive monomeric CDK fold and its ability to be remodelled by cyclin binding. Relative to CDK2-cyclin A, CDK1-cyclin B is less thermally stable, has a smaller interfacial surface, is more susceptible to activation segment dephosphorylation and shows differences in the substrate sequence features that determine activity. Both CDK1 and CDK2 are potential cancer targets for which selective compounds are required. We also describe the first structure of CDK1 bound to a potent ATP-competitive inhibitor and identify aspects of CDK1 structure and plasticity that might be exploited to develop CDK1-selective inhibitors.

  15. Creating Imaginative Worlds: Unique Details and Structure in Norma Fox Mazer's Young Adult Fiction.

    Science.gov (United States)

    Angel, Ann

    2001-01-01

    Discusses how writer Norma Fox Mazer has helped many readers make the leap between reality and imagination simply in the way she handles details in the lives of her characters. Explores the ideas of communicating with detail, experimenting with structure, and playing with time in crucial scenes. (SG)

  16. Syndecans as cell surface receptors: Unique structure equates with functional diversity

    DEFF Research Database (Denmark)

    Choi, Youngsil; Chung, Heesung; Jung, Heyjung

    2011-01-01

    An increasing number of functions for syndecan cell surface heparan sulfate proteoglycans have been proposed over the last decade. Moreover, aberrant syndecan regulation has been found to play a critical role in multiple pathologies, including cancers, as well as wound healing and inflammation. A...... glycosaminoglycan chains, especially heparan sulfate. This heterodisperse polysaccharide has the potential to interact with many ligands from diverse protein families. Here, we relate the structural features of syndecans to some of their known functions....

  17. Genetic, biological and structural hierarchies during sponge spicule formation: From soft sol-gels to solid 3D silica composite structures

    NARCIS (Netherlands)

    Wang, X.; Schröder, H.C.; Wang, K.; Kaandorp, J.A.; Müller, W.E.G.

    2012-01-01

    Structural biomaterials are hierarchically organized and biofabricated. Although the structural complexity of most bioskeletons can be traced back from the millimeter-scale to the micrometer- or submicrometer-scale, the biological and/or genetic basis controlling the synthesis of these skeletons and

  18. Maslow's Hierarchy of Needs Revisited.

    Science.gov (United States)

    Frame, Douglas

    1996-01-01

    Reviews Maslow's hierarchy of needs and characterization of the self-actualizing personality, suggesting that since few people meet his self-actualization criteria, an educational system designed to produce such personalities may fail, with teachers attending only to the hierarchy's lower stages (self-esteem and self-actualization) which dilutes…

  19. Loewner equations and dispersionless hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Takebe, Takashi [Department of Mathematics, Ochanomizu University, Otsuka 2-1-1, Bunkyo-ku, Tokyo, 112-8610 (Japan); Teo, Lee-Peng [Faculty of Information Technology, Multimedia University, Jalan Multimedia, Cyberjaya, 63100, Selangor Darul Ehsan (Malaysia); Zabrodin, Anton [Institute of Biochemical Physics, Kosygina str. 4, 119991 Moscow, Russia and ITEP, Bol. Cheremushkinskaya str. 25, 117259 Moscow (Russian Federation)

    2006-09-15

    Using the Hirota representation of dispersionless dKP and dToda hierarchies, we show that the chordal Loewner equations and radial Loewner equations respectively serve as consistency conditions for one-variable reductions of these integrable hierarchies. We also clarify the geometric meaning of this result by relating it to the eigenvalue distribution of normal random matrices in the large N limit.

  20. Maslow's Hierarchy of Needs Revisited.

    Science.gov (United States)

    Frame, Douglas

    1996-01-01

    Reviews Maslow's hierarchy of needs and characterization of the self-actualizing personality, suggesting that since few people meet his self-actualization criteria, an educational system designed to produce such personalities may fail, with teachers attending only to the hierarchy's lower stages (self-esteem and self-actualization) which dilutes…

  1. Integrating partonomic hierarchies in anatomy ontologies

    Directory of Open Access Journals (Sweden)

    Yang Yiya

    2004-11-01

    Full Text Available Abstract Background Anatomy ontologies play an increasingly important role in developing integrated bioinformatics applications. One of the primary relationships between anatomical tissues represented in such ontologies is part-of. As there are a number of ways to divide up the anatomical structure of an organism, each may be represented by more than one valid partonomic (part-of hierarchy. This raises the issue of how to represent and integrate multiple such hierarchies. Results In this paper we describe a solution that is based on our work on an anatomy ontology for mouse embryo development, which is part of the Edinburgh Mouse Atlas Project (EMAP. The paper describes the basic conceptual aspects of our approach and discusses strengths and limitations of the proposed solution. A prototype was implemented in Prolog for evaluation purposes. Conclusion With the proposed name set approach, rather than having to standardise hierarchies, it is sufficient to agree on a suitable set of basic tissue terms and their meaning in order to facilitate the integration of multiple partonomic hierarchies.

  2. Euglena gracilis ascorbate peroxidase forms an intramolecular dimeric structure: its unique molecular characterization.

    Science.gov (United States)

    Ishikawa, Takahiro; Tajima, Naoko; Nishikawa, Hitoshi; Gao, Yongshun; Rapolu, Madhusudhan; Shibata, Hitoshi; Sawa, Yoshihiro; Shigeoka, Shigeru

    2010-02-09

    Euglena gracilis lacks a catalase and contains a single APX (ascorbate peroxidase) and enzymes related to the redox cycle of ascorbate in the cytosol. In the present study, a full-length cDNA clone encoding the Euglena APX was isolated and found to contain an open reading frame encoding a protein of 649 amino acids with a calculated molecular mass of 70.5 kDa. Interestingly, the enzyme consisted of two entirely homologous catalytic domains, designated APX-N and APX-C, and an 102 amino acid extension in the N-terminal region, which had a typical class II signal proposed for plastid targeting in Euglena. A computer-assisted analysis indicated a novel protein structure with an intramolecular dimeric structure. The analysis of cell fractionation showed that the APX protein is distributed in the cytosol, but not the plastids, suggesting that Euglena APX becomes mature in the cytosol after processing of the precursor. The kinetics of the recombinant mature FL (full-length)-APX and the APX-N and APX-C domains with ascorbate and H2O2 were almost the same as that of the native enzyme. However, the substrate specificity of the mature FL-APX and the native enzyme was different from that of APX-N and APX-C. The mature FL-APX, but not the truncated forms, could reduce alkyl hydroperoxides, suggesting that the dimeric structure is correlated with substrate recognition. In Euglena cells transfected with double-stranded RNA, the silencing of APX expression resulted in a significant increase in the cellular level of H2O2, indicating the physiological importance of APX to the metabolism of H2O2.

  3. Strong guest binding by cyclodextrin hosts in competing nonpolar solvents and the unique crystalline structure.

    Science.gov (United States)

    Kida, Toshiyuki; Iwamoto, Takuya; Fujino, Yoshinori; Tohnai, Norimitsu; Miyata, Mikiji; Akashi, Mitsuru

    2011-09-02

    6-O-Modified β-cyclodextrins, such as heptakis(6-O-triisopropylsilyl)-β-cyclodextrin (TIPS-β-CD) and heptakis(6-O-tert-butyldimethylsilyl)-β-cyclodextrin (TBDMS-β-CD), formed 2:1 inclusion complexes with pyrene in benzene and cyclohexane with high association constants. The X-ray crystalline structure of the TIPS-β-CD-pyrene complex obtained from the benzene solution showed that one pyrene molecule was incorporated in the form of a sandwich-type complex with two benzene molecules within the cavity of the dimer formed by two TIPS-β-CD molecules.

  4. Centrally extended W$_{1+\\infty}$ and the KP hierarchy

    CERN Document Server

    Martínez-Moras, F; Martinez-Moras, Fernando; Mas, Javier

    1994-01-01

    It is well known that the centerless \\W_{1+\\infty} algebra provides a hamiltonian structure for the KP hierarchy. In this letter we address the question whether the centerfull version plays a similar r\\^ole in any related integrable system. We find that, surprisingly enough the centrally extended W_{1+\\infty} algebra yields another Poisson structure for the same standard KP hierarchy. This is proven by explicit construction of the infinitely many new hamiltonians in closed form.

  5. Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter

    Energy Technology Data Exchange (ETDEWEB)

    Deka, Ranjit K.; Brautigam, Chad A.; Goldberg, Martin; Schuck, Peter; Tomchick, Diana R.; Norgard, Michael V. (NIH); (UTSMC)

    2012-05-25

    Treponema pallidum, the bacterial agent of syphilis, is predicted to encode one tripartite ATP-independent periplasmic transporter (TRAP-T). TRAP-Ts typically employ a periplasmic substrate-binding protein (SBP) to deliver the cognate ligand to the transmembrane symporter. Herein, we demonstrate that the genes encoding the putative TRAP-T components from T. pallidum, tp0957 (the SBP), and tp0958 (the symporter), are in an operon with an uncharacterized third gene, tp0956. We determined the crystal structure of recombinant Tp0956; the protein is trimeric and perforated by a pore. Part of Tp0956 forms an assembly similar to those of 'tetratricopeptide repeat' (TPR) motifs. The crystal structure of recombinant Tp0957 was also determined; like the SBPs of other TRAP-Ts, there are two lobes separated by a cleft. In these other SBPs, the cleft binds a negatively charged ligand. However, the cleft of Tp0957 has a strikingly hydrophobic chemical composition, indicating that its ligand may be substantially different and likely hydrophobic. Analytical ultracentrifugation of the recombinant versions of Tp0956 and Tp0957 established that these proteins associate avidly. This unprecedented interaction was confirmed for the native molecules using in vivo cross-linking experiments. Finally, bioinformatic analyses suggested that this transporter exemplifies a new subfamily of TPATs (TPR-protein-associated TRAP-Ts) that require the action of a TPR-containing accessory protein for the periplasmic transport of a potentially hydrophobic ligand(s).

  6. Structure of the Membrane-tethering GRASP Domain Reveals a Unique PDZ Ligand Interaction That Mediates Golgi Biogenesis

    Energy Technology Data Exchange (ETDEWEB)

    S Truschel; D Sengupta; A Foote; A Heroux; M Macbeth; A Linstedt

    2011-12-31

    Biogenesis of the ribbon-like membrane network of the mammalian Golgi requires membrane tethering by the conserved GRASP domain in GRASP65 and GRASP55, yet the tethering mechanism is not fully understood. Here, we report the crystal structure of the GRASP55 GRASP domain, which revealed an unusual arrangement of two tandem PDZ folds that more closely resemble prokaryotic PDZ domains. Biochemical and functional data indicated that the interaction between the ligand-binding pocket of PDZ1 and an internal ligand on PDZ2 mediates the GRASP self-interaction, and structural analyses suggest that this occurs via a unique mode of internal PDZ ligand recognition. Our data uncover the structural basis for ligand specificity and provide insight into the mechanism of GRASP-dependent membrane tethering of analogous Golgi cisternae.

  7. Structure of the Membrane-tethering GRASP Domain Reveals a Unique PDZ Ligand Interaction That Mediates Golgi Biogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Truschel, S.T.; Heroux, A.; Sengupta, D.; Foote, A.; Macbeth, M. R.; Linstedt, A. D.

    2011-06-10

    Biogenesis of the ribbon-like membrane network of the mammalian Golgi requires membrane tethering by the conserved GRASP domain in GRASP65 and GRASP55, yet the tethering mechanism is not fully understood. Here, we report the crystal structure of the GRASP55 GRASP domain, which revealed an unusual arrangement of two tandem PDZ folds that more closely resemble prokaryotic PDZ domains. Biochemical and functional data indicated that the interaction between the ligand-binding pocket of PDZ1 and an internal ligand on PDZ2 mediates the GRASP self-interaction, and structural analyses suggest that this occurs via a unique mode of internal PDZ ligand recognition. Our data uncover the structural basis for ligand specificity and provide insight into the mechanism of GRASP-dependent membrane tethering of analogous Golgi cisternae.

  8. Novel Fluorinated Indanone, Tetralone and Naphthone Derivatives: Synthesis and Unique Structural Features

    Directory of Open Access Journals (Sweden)

    Joseph C. Sloop

    2012-02-01

    Full Text Available Several fluorinated and trifluoromethylated indanone, tetralone and naphthone derivatives have been prepared via Claisen condensations and selective fluorinations in yields ranging from 22–60%. In addition, we report the synthesis of new, selectively fluorinated bindones in yields ranging from 72–92%. Of particular interest is the fluorination and trifluoroacetylation regiochemistry observed in these fluorinated products. We also note unusual transformations including a novel one pot, dual trifluoroacetylation, trifluoroacetylnaphthone synthesis via a deacetylation as well as an acetyl-trifluoroacetyl group exchange. Solid-state structural features exhibited by these compounds were investigated using crystallographic methods. Crystallographic results, supported by spectroscopic data, show that trifluoroacetylated ketones prefer a chelated cis-enol form whereas fluorinated bindone products exist primarily as the cross-conjugated triketo form.

  9. Poly(ADP-ribose)--a unique natural polymer structural features, biological role and approaches to the chemical synthesis.

    Science.gov (United States)

    Drenichev, Mikhail S; Mikhailov, Sergey N

    2015-01-01

    Poly(ADP-ribose) (PAR) is a natural polymer, taking part in numerous important cellular processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of them, poly(ADP-ribose)polymerase-1 (PARP-1) is considered to be a perspective target for the design of new drugs, affecting PAR metabolism. The structure of PAR was established by enzymatic hydrolysis and further analysis of the products, but total chemical synthesis of PAR hasn't been described yet. Several approaches have been developed on the way to chemical synthesis of this unique biopolymer.

  10. Weak Genetic Structure in Northern African Dromedary Camels Reflects Their Unique Evolutionary History

    Science.gov (United States)

    Cherifi, Youcef Amine; Gaouar, Suheil Bechir Semir; Guastamacchia, Rosangela; El-Bahrawy, Khalid Ahmed; Abushady, Asmaa Mohammed Aly; Sharaf, Abdoallah Aboelnasr; Harek, Derradji; Lacalandra, Giovanni Michele; Saïdi-Mehtar, Nadhira

    2017-01-01

    Knowledge on genetic diversity and structure of camel populations is fundamental for sustainable herd management and breeding program implementation in this species. Here we characterized a total of 331 camels from Northern Africa, representative of six populations and thirteen Algerian and Egyptian geographic regions, using 20 STR markers. The nineteen polymorphic loci displayed an average of 9.79 ± 5.31 alleles, ranging from 2 (CVRL8) to 24 (CVRL1D). Average He was 0.647 ± 0.173. Eleven loci deviated significantly from Hardy-Weinberg proportions (P<0.05), due to excess of homozygous genotypes in all cases except one (CMS18). Distribution of genetic diversity along a weak geographic gradient as suggested by network analysis was not supported by either unsupervised and supervised Bayesian clustering. Traditional extensive/nomadic herding practices, together with the historical use as a long-range beast of burden and its peculiar evolutionary history, with domestication likely occurring from a bottlenecked and geographically confined wild progenitor, may explain the observed genetic patterns. PMID:28103238

  11. Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae.

    Science.gov (United States)

    Becker, Argentina; Kannan, T R; Taylor, Alexander B; Pakhomova, Olga N; Zhang, Yanfeng; Somarajan, Sudha R; Galaleldeen, Ahmad; Holloway, Stephen P; Baseman, Joel B; Hart, P John

    2015-04-21

    Mycoplasma pneumoniae (Mp) infections cause tracheobronchitis and "walking" pneumonia, and are linked to asthma and other reactive airway diseases. As part of the infectious process, the bacterium expresses a 591-aa virulence factor with both mono-ADP ribosyltransferase (mART) and vacuolating activities known as Community-Acquired Respiratory Distress Syndrome Toxin (CARDS TX). CARDS TX binds to human surfactant protein A and annexin A2 on airway epithelial cells and is internalized, leading to a range of pathogenetic events. Here we present the structure of CARDS TX, a triangular molecule in which N-terminal mART and C-terminal tandem β-trefoil domains associate to form an overall architecture distinct from other well-recognized ADP-ribosylating bacterial toxins. We demonstrate that CARDS TX binds phosphatidylcholine and sphingomyelin specifically over other membrane lipids, and that cell surface binding and internalization activities are housed within the C-terminal β-trefoil domain. The results enhance our understanding of Mp pathogenicity and suggest a novel avenue for the development of therapies to treat Mp-associated asthma and other acute and chronic airway diseases.

  12. Context-dependent hierarchies in pigeons.

    Science.gov (United States)

    Nagy, Máté; Vásárhelyi, Gábor; Pettit, Benjamin; Roberts-Mariani, Isabella; Vicsek, Tamás; Biro, Dora

    2013-08-06

    Hierarchical organization is widespread in the societies of humans and other animals, both in social structure and in decision-making contexts. In the case of collective motion, the majority of case studies report that dominant individuals lead group movements, in agreement with the common conflation of the terms "dominance" and "leadership." From a theoretical perspective, if social relationships influence interactions during collective motion, then social structure could also affect leadership in large, swarm-like groups, such as fish shoals and bird flocks. Here we use computer-vision-based methods and miniature GPS tracking to study, respectively, social dominance and in-flight leader-follower relations in pigeons. In both types of behavior we find hierarchically structured networks of directed interactions. However, instead of being conflated, dominance and leadership hierarchies are completely independent of each other. Although dominance is an important aspect of variation among pigeons, correlated with aggression and access to food, our results imply that the stable leadership hierarchies in the air must be based on a different set of individual competences. In addition to confirming the existence of independent and context-specific hierarchies in pigeons, we succeed in setting out a robust, scalable method for the automated analysis of dominance relationships, and thus of social structure, applicable to many species. Our results, as well as our methods, will help to incorporate the broader context of animal social organization into the study of collective behavior.

  13. Extensive genetic diversity, unique population structure and evidence of genetic exchange in the sexually transmitted parasite Trichomonas vaginalis.

    Directory of Open Access Journals (Sweden)

    Melissa D Conrad

    Full Text Available Trichomonas vaginalis is the causative agent of human trichomoniasis, the most common non-viral sexually transmitted infection world-wide. Despite its prevalence, little is known about the genetic diversity and population structure of this haploid parasite due to the lack of appropriate tools. The development of a panel of microsatellite makers and SNPs from mining the parasite's genome sequence has paved the way to a global analysis of the genetic structure of the pathogen and association with clinical phenotypes.Here we utilize a panel of T. vaginalis-specific genetic markers to genotype 235 isolates from Mexico, Chile, India, Australia, Papua New Guinea, Italy, Africa and the United States, including 19 clinical isolates recently collected from 270 women attending New York City sexually transmitted disease clinics. Using population genetic analysis, we show that T. vaginalis is a genetically diverse parasite with a unique population structure consisting of two types present in equal proportions world-wide. Parasites belonging to the two types (type 1 and type 2 differ significantly in the rate at which they harbor the T. vaginalis virus, a dsRNA virus implicated in parasite pathogenesis, and in their sensitivity to the widely-used drug, metronidazole. We also uncover evidence of genetic exchange, indicating a sexual life-cycle of the parasite despite an absence of morphologically-distinct sexual stages.Our study represents the first robust and comprehensive evaluation of global T. vaginalis genetic diversity and population structure. Our identification of a unique two-type structure, and the clinically relevant phenotypes associated with them, provides a new dimension for understanding T. vaginalis pathogenesis. In addition, our demonstration of the possibility of genetic exchange in the parasite has important implications for genetic research and control of the disease.

  14. Stress amplifies memory for social hierarchy

    Directory of Open Access Journals (Sweden)

    María I Cordero

    2007-10-01

    Full Text Available Individuals differ in their social status and societies in the extent of social status differences among their members. There is great interest in understanding the key factors that contribute to the establishment of social dominance structures. Given that stress can affect behavior and cognition, we hypothesized that, given equal opportunities to become either dominant or submissive, stress experienced by one of the individuals during their first encounter would determine the long-term establishment of a social hierarchy by acting as a two-stage rocket: (1 by influencing the rank achieved after a social encounter and (2 by facilitating and/or promoting a long-term memory for the specific hierarchy. Using a novel model for the assessment of long-term dominance hierarchies in rats, we present here the first evidence supporting such hypothesis. In control conditions, the social rank established through a first interaction and food competition test between two male rats is not maintained when animals are confronted 1 week later. However, if one of the rats is stressed just before their first encounter, the dominance hierarchy developed on day 1 is still clearly observed 1 week later, with the stressed animal becoming submissive (i.e., looser in competition tests in both social interactions. Our findings also allow us to propose that stress potentiates a hierarchy-linked recognition memory between “specific” individuals through mechanisms that involve de novo protein synthesis. These results implicate stress among the key mechanisms contributing to create social imbalance and highlight memory mechanisms as key mediators of stress-induced long-term establishment of social rank.

  15. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition

    Energy Technology Data Exchange (ETDEWEB)

    Chaptal, Vincent; Kwon, Seunghyug; Sawaya, Michael R.; Guan, Lan; Kaback, H. Ronald; Abramson, Jeff (UCLA); (TTU)

    2011-08-29

    Lactose permease of Escherichia coli (LacY) with a single-Cys residue in place of A122 (helix IV) transports galactopyranosides and is specifically inactivated by methanethiosulfonyl-galactopyranosides (MTS-gal), which behave as unique suicide substrates. In order to study the mechanism of inactivation more precisely, we solved the structure of single-Cys122 LacY in complex with covalently bound MTS-gal. This structure exhibits an inward-facing conformation similar to that observed previously with a slight narrowing of the cytoplasmic cavity. MTS-gal is bound covalently, forming a disulfide bond with C122 and positioned between R144 and W151. E269, a residue essential for binding, coordinates the C-4 hydroxyl of the galactopyranoside moiety. The location of the sugar is in accord with many biochemical studies.

  16. Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition.

    Science.gov (United States)

    Chaptal, Vincent; Kwon, Seunghyug; Sawaya, Michael R; Guan, Lan; Kaback, H Ronald; Abramson, Jeff

    2011-06-07

    Lactose permease of Escherichia coli (LacY) with a single-Cys residue in place of A122 (helix IV) transports galactopyranosides and is specifically inactivated by methanethiosulfonyl-galactopyranosides (MTS-gal), which behave as unique suicide substrates. In order to study the mechanism of inactivation more precisely, we solved the structure of single-Cys122 LacY in complex with covalently bound MTS-gal. This structure exhibits an inward-facing conformation similar to that observed previously with a slight narrowing of the cytoplasmic cavity. MTS-gal is bound covalently, forming a disulfide bond with C122 and positioned between R144 and W151. E269, a residue essential for binding, coordinates the C-4 hydroxyl of the galactopyranoside moiety. The location of the sugar is in accord with many biochemical studies.

  17. Anarchy and hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Haba, Naoyuki; Murayama, Hitoshi

    2000-09-14

    We advocate a new approach to study models of fermion massesand mixings, namely anarchy proposed in hep-ph/9911341. In this approach,we scan the O(1) coefficients randomly. We argue that this is the correctapproach when the fundamental theory is sufficiently complicated.Assuming there is no physical distinction among three generations ofneutrinos, the probability distributions in MNS mixing angles can bepredicted independent of the choice of the measure. This is because themixing angles are distributed according to the Haar measure of the Liegroups whose elements diagonalize the mass matrices. The near-maximalmixings, as observed in the atmospheric neutrino data and as required inthe LMA solution to the solar neutrino problem, are highly probable. Asmall hierarchy between the Delta m2 for the atmospheric and the solarneutrinos is obtained very easily; the complex seesaw case gives ahierarchy of a factor of 20 as the most probable one, even though thisconclusion is more measure-dependent. U_e3 has to be just below thecurrent limit from the CHOOZ experiment. The CP-violating parameter sindelta is preferred to be maximal. We present a simple SU(5)-likeextension of anarchy to the charged-lepton and quark sectors which workswell phenomenologically.

  18. Scalable distributed computing hierarchy: cloud, fog and dew computing

    OpenAIRE

    Skala, Karolj; Davidović, Davor; Afgan, Enis; Sović, Ivan; Šojat, Zorislav

    2015-01-01

    The paper considers the conceptual approach for organization of the vertical hierarchical links between the scalable distributed computing paradigms: Cloud Computing, Fog Computing and Dew Computing. In this paper, the Dew Computing is described and recognized as a new structural layer in the existing distributed computing hierarchy. In the existing computing hierarchy, the Dew computing is positioned as the ground level for the Cloud and Fog computing paradigms. Vertical, complementary, hier...

  19. A unique semiconductor-carbon-metal hybrid structure design as a counter electrode in dye-sensitized solar cells.

    Science.gov (United States)

    Guo, Sheng-Qi; Wang, Ling-Chang; Zhang, Chen-Guang; Qi, Gao-Can; Gu, Bing-Chuan; Liu, Lu; Yuan, Zhi-Hao

    2017-05-25

    The catalytic activity of counter electrodes (CEs) severely restricts the photovoltaic conversion efficiency of dye-sensitized solar cells. However, electrons trapped by bulk defects greatly reduce the catalytic activity of the CE. In this study, we report a novel In2S3-C-Au hybrid structure designed by simply decorating Au particles on the surface of carbon-coated hierarchical In2S3 flower-like architectures, which could avoid the abovementioned problems. This effect can be attributed to the unique contribution of indium sulfide, carbon, and Au from the hybrid structure, as well as to their synergy. Electrochemical measurements revealed that the hybrid structure possessed high catalytic activity and electrochemical stability for the interconversion of the redox couple I3(-)/I(-). Moreover, this superior performance can be incorporated into the dye-sensitized solar cells system. We used this hybrid structure as a counter electrode by casting it on an FTO substrate to form a film, which displayed better photovoltaic conversion efficiency (8.91%) than the commercial Pt counterpart (7.67%).

  20. Hierarchies of Predominantly Connected Communities

    CERN Document Server

    Hamann, Michael; Wagner, Dorothea

    2013-01-01

    We consider communities whose vertices are predominantly connected, i.e., the vertices in each community are stronger connected to other community members of the same community than to vertices outside the community. Flake et al. introduced a hierarchical clustering algorithm that finds such predominantly connected communities of different coarseness depending on an input parameter. We present a simple and efficient method for constructing a clustering hierarchy according to Flake et al. that supersedes the necessity of choosing feasible parameter values and guarantees the completeness of the resulting hierarchy, i.e., the hierarchy contains all clusterings that can be constructed by the original algorithm for any parameter value. However, predominantly connected communities are not organized in a single hierarchy. Thus, we develop a framework that, after precomputing at most $2(n-1)$ maximum flows, admits a linear time construction of a clustering $\\C(S)$ of predominantly connected communities that contains ...

  1. 基于层次分析法的建筑工程专业课程设置研究%Course arrangement of structural engineering based on analytic hierarchy process

    Institute of Scientific and Technical Information of China (English)

    茹忠亮

    2012-01-01

    According to the curriculum system of structural engineering, the hierarchical structure of the curriculum system using analytic hierarchy process (AHP) was designed and the weight of each course in the curriculum system was determined by constructing and analyzing the judgment matrix. The results can provide a reference for the training scheme construction of structural engineering reasonably.%针对建筑工程专业课程体系设置,运用层次分析法构建课程体系模型,通过构造成对比较矩阵,确定了各门课程在课程体系中所占权重。研究结果为制定合理的专业培养方案提供参考依据。

  2. Principles of synchronous digital hierarchy

    CERN Document Server

    Jain, Rajesh Kumar

    2012-01-01

    The book presents the current standards of digital multiplexing, called synchronous digital hierarchy, including analog multiplexing technologies. It is aimed at telecommunication professionals who want to develop an understanding of digital multiplexing and synchronous digital hierarchy in particular and the functioning of practical telecommunication systems in general. The text includes all relevant fundamentals and provides a handy reference for problem solving or defining operations and maintenance strategies. The author covers digital conversion and TDM principles, line coding and digital

  3. The Return of the Hierarchy

    DEFF Research Database (Denmark)

    Tolstrup Christensen, Lene

    2015-01-01

    corporatisation. This layered set-up provided the state with a double governance grip that drove marketisation until 2011. However, the SOE as a hybrid created ripple effects between the market and the hierarchy that hampered the marketisation. The hierarchical governance turned towards centralisation and market....... It presents a case on how hybridity is altered and evolves in SOEs as a hybrid mode of governance between hierarchy and market in marketisation and how this can lead to re-centralisation....

  4. Information slows down hierarchy growth.

    Science.gov (United States)

    Czaplicka, Agnieszka; Suchecki, Krzysztof; Miñano, Borja; Trias, Miquel; Hołyst, Janusz A

    2014-06-01

    We consider models of growing multilevel systems wherein the growth process is driven by rules of tournament selection. A system can be conceived as an evolving tree with a new node being attached to a contestant node at the best hierarchy level (a level nearest to the tree root). The proposed evolution reflects limited information on system properties available to new nodes. It can also be expressed in terms of population dynamics. Two models are considered: a constant tournament (CT) model wherein the number of tournament participants is constant throughout system evolution, and a proportional tournament (PT) model where this number increases proportionally to the growing size of the system itself. The results of analytical calculations based on a rate equation fit well to numerical simulations for both models. In the CT model all hierarchy levels emerge, but the birth time of a consecutive hierarchy level increases exponentially or faster for each new level. The number of nodes at the first hierarchy level grows logarithmically in time, while the size of the last, "worst" hierarchy level oscillates quasi-log-periodically. In the PT model, the occupations of the first two hierarchy levels increase linearly, but worse hierarchy levels either do not emerge at all or appear only by chance in the early stage of system evolution to further stop growing at all. The results allow us to conclude that information available to each new node in tournament dynamics restrains the emergence of new hierarchy levels and that it is the absolute amount of information, not relative, which governs such behavior.

  5. An Imperative Type Hierarchy with Partial Products

    DEFF Research Database (Denmark)

    Schwartzbach, Michael Ignatieff; Schmidt, Erik Meineche

    1989-01-01

    notation for defining recursive types, that is superior to traditional type sums and products. We show how the ordering on types extends to an ordering on types with invariants. We allow the use of least upper bounds in type definitions and show how to compute upper bounds of invariants.......A type hierarchy for a programming language defines an ordering on the types such that any application for small types may be reused for all larger types. The imperative facet makes this non-trivial; the straight-forward definitions will yield an inconsistent system. We introduce a new type...... constructor, the partial product, and show how to define a consistent hierarchy in the context of fully recursive types. A simple polymorphism is derived by introducing a notion of placeholder types. By extending the partial product types to include structural invariants we obtain a particularly appropriate...

  6. Deep Hierarchies in the Primate Visual Cortex

    DEFF Research Database (Denmark)

    Krüger, Norbert; Jannsen, Per; Kalkan, S.

    2013-01-01

    Computational modeling of the primate visual system yields insights of potential relevance to some of the challenges that computer vision is facing, such as object recognition and categorization, motion detection and activity recognition or vision-based navigation and manipulation. This article...... reviews some functional principles and structures that are generally thought to underlie the primate visual cortex, and attempts to extract biological principles that could further advance computer vision research. Organized for a computer vision audience, we present functional principles...... of the processing hierarchies present in the primate visual system considering recent discoveries in neurophysiology. The hierarchal processing in the primate visual system is characterized by a sequence of different levels of processing (in the order of ten) that constitute a deep hierarchy in contrast to the flat...

  7. Hierarchy of Scales in Language Dynamics

    CERN Document Server

    Blythe, Richard A

    2015-01-01

    Methods and insights from statistical physics are finding an increasing variety of applications where one seeks to understand the emergent properties of a complex interacting system. One such area concerns the dynamics of language at a variety of levels of description, from the behaviour of individual agents learning simple artificial languages from each other, up to changes in the structure of languages shared by large groups of speakers over historical timescales. In this Colloquium, we survey a hierarchy of scales at which language and linguistic behaviour can be described, along with the main progress in understanding that has been made at each of them---much of which has come from the statistical physics community. We argue that future developments may arise by linking the different levels of the hierarchy together in a more coherent fashion, in particular where this allows more effective use of rich empirical data sets.

  8. The Basis of the Syllable Hierarchy: Articulatory Pressures or Universal Phonological Constraints?

    Science.gov (United States)

    Zhao, Xu; Berent, Iris

    2017-07-14

    Across languages, certain syllable types are systematically preferred to others (e.g., [Formula: see text] lbif, where [Formula: see text] indicates a preference). Previous research has shown that these preferences are active in the brains of individual speakers, they are evident even when none of these syllable types exists in participants' language, and even when the stimuli are presented in print. These results suggest that the syllable hierarchy cannot be reduced to either lexical or auditory/phonetic pressures. Here, we examine whether the syllable hierarchy is due to articulatory pressures. According to the motor embodiment view, the perception of a linguistic stimulus requires simulating its production; dispreferred syllables (e.g., lbif) are universally disliked because their production is harder to simulate. To address this possibility, we assessed syllable preferences while articulation was mechanically suppressed. Our four experiments each found significant effects of suppression. Remarkably, people remained sensitive to the syllable hierarchy regardless of suppression. Specifically, results with auditory materials (Experiments 1-2) showed strong effects of syllable structure irrespective of suppression. Moreover, syllable structure uniquely accounted for listeners' behavior even when controlling for several phonetic characteristics of our auditory materials. Results with printed stimuli (Experiments 3-4) were more complex, as participants in these experiments relied on both phonological and graphemic information. Nonetheless, readers were sensitive to most of the syllable hierarchy (e.g., [Formula: see text]), and these preferences emerged when articulation was suppressed, and even when the statistical properties of our materials were controlled via a regression analysis. Together, these findings indicate that speakers possess broad grammatical preferences that are irreducible to either sensory or motor factors.

  9. Hierarchies in Dictionary Definition Space

    CERN Document Server

    Picard, Olivier; Harnad, Stevan; Marcotte, Odile; Chicoisne, Guillaume; Gargouri, Yassine

    2009-01-01

    A dictionary defines words in terms of other words. Definitions can tell you the meanings of words you don't know, but only if you know the meanings of the defining words. How many words do you need to know (and which ones) in order to be able to learn all the rest from definitions? We reduced dictionaries to their "grounding kernels" (GKs), about 10% of the dictionary, from which all the other words could be defined. The GK words turned out to have psycholinguistic correlates: they were learned at an earlier age and more concrete than the rest of the dictionary. But one can compress still more: the GK turns out to have internal structure, with a strongly connected "kernel core" (KC) and a surrounding layer, from which a hierarchy of definitional distances can be derived, all the way out to the periphery of the full dictionary. These definitional distances, too, are correlated with psycholinguistic variables (age of acquisition, concreteness, imageability, oral and written frequency) and hence perhaps with th...

  10. Crystal structures and inhibitor binding properties of plant class V chitinases: the cycad enzyme exhibits unique structural and functional features.

    Science.gov (United States)

    Umemoto, Naoyuki; Kanda, Yuka; Ohnuma, Takayuki; Osawa, Takuo; Numata, Tomoyuki; Sakuda, Shohei; Taira, Toki; Fukamizo, Tamo

    2015-04-01

    A class V (glycoside hydrolase family 18) chitinase from the cycad Cycas revoluta (CrChiA) is a plant chitinase that has been reported to possess efficient transglycosylation (TG) activity. We solved the crystal structure of CrChiA, and compared it with those of class V chitinases from Nicotiana tabacum (NtChiV) and Arabidopsis thaliana (AtChiC), which do not efficiently catalyze the TG reaction. All three chitinases had a similar (α/β)8 barrel fold with an (α + β) insertion domain. In the acceptor binding site (+1, +2 and +3) of CrChiA, the Trp168 side chain was found to stack face-to-face with the +3 sugar. However, this interaction was not found in the identical regions of NtChiV and AtChiC. In the DxDxE motif, which is essential for catalysis, the carboxyl group of the middle Asp (Asp117) was always oriented toward the catalytic acid Glu119 in CrChiA, whereas the corresponding Asp in NtChiV and AtChiC was oriented toward the first Asp. These structural features of CrChiA appear to be responsible for the efficient TG activity. When binding of the inhibitor allosamidin was evaluated using isothermal titration calorimetry, the changes in binding free energy of the three chitinases were found to be similar to each other, i.e. between -9.5 and -9.8 kcal mol(-1) . However, solvation and conformational entropy changes in CrChiA were markedly different from those in NtChiV and AtChiC, but similar to those of chitinase A from Serratia marcescens (SmChiA), which also exhibits significant TG activity. These results provide insight into the molecular mechanism underlying the TG reaction and the molecular evolution from bacterial chitinases to plant class V chitinases.

  11. Do Convolutional Neural Networks Learn Class Hierarchy?

    Science.gov (United States)

    Alsallakh, Bilal; Jourabloo, Amin; Ye, Mao; Liu, Xiaoming; Ren, Liu

    2017-08-29

    Convolutional Neural Networks (CNNs) currently achieve state-of-the-art accuracy in image classification. With a growing number of classes, the accuracy usually drops as the possibilities of confusion increase. Interestingly, the class confusion patterns follow a hierarchical structure over the classes. We present visual-analytics methods to reveal and analyze this hierarchy of similar classes in relation with CNN-internal data. We found that this hierarchy not only dictates the confusion patterns between the classes, it furthermore dictates the learning behavior of CNNs. In particular, the early layers in these networks develop feature detectors that can separate high-level groups of classes quite well, even after a few training epochs. In contrast, the latter layers require substantially more epochs to develop specialized feature detectors that can separate individual classes. We demonstrate how these insights are key to significant improvement in accuracy by designing hierarchy-aware CNNs that accelerate model convergence and alleviate overfitting. We further demonstrate how our methods help in identifying various quality issues in the training data.

  12. Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans.

    Directory of Open Access Journals (Sweden)

    Michiko Itoh

    Full Text Available Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH is poorly understood. Here we report the unique histological structure termed "hepatic crown-like structures (hCLS" in the mouse model of human NASH; melanocortin-4 receptor deficient mice fed a Western diet. In hCLS, CD11c-positive macrophages aggregate to surround hepatocytes with large lipid droplets, which is similar to those described in obese adipose tissue. Histological analysis revealed that hCLS is closely associated with activated fibroblasts and collagen deposition. When treatment with clodronate liposomes effectively depletes macrophages scattered in the liver, with those in hCLS intact, hepatic expression of inflammatory and fibrogenic genes is unaffected, suggesting that hCLS is an important source of inflammation and fibrosis during the progression of NASH. Notably, the number of hCLS is positively correlated with the extent of liver fibrosis. We also observed increased number of hCLS in the liver of non-alcoholic fatty liver disease/NASH patients. Collectively, our data provide evidence that hCLS is involved in the development of hepatic inflammation and fibrosis, thereby suggesting its pathophysiologic role in disease progression from simple steatosis to NASH.

  13. The structure of a bottlenose dolphin society is coupled to a unique foraging cooperation with artisanal fishermen.

    Science.gov (United States)

    Daura-Jorge, F G; Cantor, M; Ingram, S N; Lusseau, D; Simões-Lopes, P C

    2012-10-23

    Diverse and localized foraging behaviours have been reported in isolated populations of many animal species around the world. In Laguna, southern Brazil, a subset of resident bottlenose dolphins (Tursiops truncatus) uses a foraging tactic involving cooperative interactions with local, beach-casting fishermen. We used individual photo-identification data to assess whether cooperative and non-cooperative dolphins were socially segregated. The social structure of the population was found to be a fission-fusion system with few non-random associations, typical for this species. However, association values were greater among cooperative dolphins than among non-cooperative dolphins or between dolphins from different foraging classes. Furthermore, the dolphin social network was divided into three modules, clustering individuals that shared or lacked the cooperative foraging tactic. Space-use patterns were not sufficient to explain this partitioning, indicating a behavioural factor. The segregation of dolphins using different foraging tactics could result from foraging behaviour driving social structure, while the closer association between dolphins engaged in the cooperation could facilitate the transmission and learning of this behavioural trait from conspecifics. This unique case of a dolphin-human interaction represents a valuable opportunity to explore hypotheses on the role of social learning in wild cetaceans.

  14. Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP).

    Science.gov (United States)

    Romanelli, M N; Manetti, D; Scapecchi, S; Borea, P A; Dei, S; Bartolini, A; Ghelardini, C; Gualtieri, F; Guandalini, L; Varani, K

    2001-11-08

    DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the past decades. A systematic modulation of the chemical structure of DMPP, aimed to establish its structure-affinity relationships, is reported. The research has allowed to identify molecules such as 11c, 13c, 14c, and 28c, with affinities for alpha(4)beta(2) receptors in the low nanomolar range, some 2 orders of magnitude lower than the lead compound. The agonistic properties of the most interesting compounds have been assessed by measuring their analgesic activity on mice (hot-plate test). Another result of the research was the identification of DMPP analogues, such as 3a (K(i) = 90 nM) and 14b (K(i) = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases.

  15. Information slows down hierarchy growth

    CERN Document Server

    Czaplicka, Agnieszka; Minano, Borja; Trias, Miquel; Holyst, Janusz A

    2013-01-01

    We consider models of a growing tree with the growth process driven by the rules of tournament selection, where a new node is attached to a contestant node at the best hierarchy level (closest to the tree root). The proposed evolution reflects limited information about the network topology that is available for new nodes. Two cases are considered: the constant tournament (CT) model where the number of tournament participants is constant throughout the tree evolution, and the proportional tournament (PT) model where it is grows proportionally to the actual tree size. The results of analytical calculations based on a rate equation fit well to numerical simulations for both models. In the CT model all hierarchy levels emerge in the tree but the birth time of the hierarchy level increases exponentially or faster with level number. The number of nodes at the first hierarchy level (just below the root) grows logarithmically in time, while the size of the last, "worst" hierarchy level oscillates quasi log-periodical...

  16. Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain.

    Science.gov (United States)

    Xia, Yitian; Shang, Yuan; Zhang, Rongguang; Zhu, Jinwei

    2017-08-10

    The PSD-95 family of membrane-associated guanylate kinases (MAGUKs) are major synaptic scaffold proteins and play crucial roles in the dynamic regulation of dendritic remodelling, which is understood to be the foundation of synaptogenesis and synaptic plasticity. The guanylate kinase (GK) domain of MAGUK family proteins functions as a phosphor-peptide binding module. However, the GK domain of PSD-95 has been found to directly bind to a peptide sequence within the C-terminal region of neuronal-specific microtubule-associated protein 1A (MAP1A), although the detailed molecular mechanism governing this phosphorylation-independent interaction at the atomic level is missing. In the present study, we determine the crystal structure of PSD-95 GK in complex with the MAP1A peptide at 2.6-Å resolution. The complex structure reveals that, unlike a linear and elongated conformation in the phosphor-peptide/GK complexes, the MAP1A peptide adopts a unique conformation with a stretch of hydrophobic residues far from each other in the primary sequence clustering and interacting with the 'hydrophobic site' of PSD-95 GK and a highly conserved aspartic acid of MAP1A (D2117) mimicking the phosphor-serine/threonine in binding to the 'phosphor-site' of PSD-95 GK. We demonstrate that the MAP1A peptide may undergo a conformational transition upon binding to PSD-95 GK. Further structural comparison of known DLG GK-mediated complexes reveals the target recognition specificity and versatility of DLG GKs. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

  17. Two unique ligand-binding clamps of Rhizopus oryzae starch binding domain for helical structure disruption of amylose.

    Directory of Open Access Journals (Sweden)

    Ting-Ying Jiang

    Full Text Available The N-terminal starch binding domain of Rhizopus oryzae glucoamylase (RoSBD has a high binding affinity for raw starch. RoSBD has two ligand-binding sites, each containing a ligand-binding clamp: a polyN clamp residing near binding site I is unique in that it is expressed in only three members of carbohydrate binding module family 21 (CBM21 members, and a Y32/F58 clamp located at binding site II is conserved in several CBMs. Here we characterized different roles of these sites in the binding of insoluble and soluble starches using an amylose-iodine complex assay, atomic force microscopy, isothermal titration calorimetry, site-directed mutagenesis, and structural bioinformatics. RoSBD induced the release of iodine from the amylose helical cavity and disrupted the helical structure of amylose type III, thereby significantly diminishing the thickness and length of the amylose type III fibrils. A point mutation in the critical ligand-binding residues of sites I and II, however, reduced both the binding affinity and amylose helix disruption. This is the first molecular model for structure disruption of the amylose helix by a non-hydrolytic CBM21 member. RoSBD apparently twists the helical amylose strands apart to expose more ligand surface for further SBD binding. Repeating the process triggers the relaxation and unwinding of amylose helices to generate thinner and shorter amylose fibrils, which are more susceptible to hydrolysis by glucoamylase. This model aids in understanding the natural roles of CBMs in protein-glycan interactions and contributes to potential molecular engineering of CBMs.

  18. Poisson hierarchy of discrete strings

    Energy Technology Data Exchange (ETDEWEB)

    Ioannidou, Theodora, E-mail: ti3@auth.gr [Faculty of Civil Engineering, School of Engineering, Aristotle University of Thessaloniki, 54249, Thessaloniki (Greece); Niemi, Antti J., E-mail: Antti.Niemi@physics.uu.se [Department of Physics and Astronomy, Uppsala University, P.O. Box 803, S-75108, Uppsala (Sweden); Laboratoire de Mathematiques et Physique Theorique CNRS UMR 6083, Fédération Denis Poisson, Université de Tours, Parc de Grandmont, F37200, Tours (France); Department of Physics, Beijing Institute of Technology, Haidian District, Beijing 100081 (China)

    2016-01-28

    The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.

  19. Inequality matters: classroom status hierarchy and adolescents' bullying.

    Science.gov (United States)

    Garandeau, Claire F; Lee, Ihno A; Salmivalli, Christina

    2014-07-01

    The natural emergence of status hierarchies in adolescent peer groups has long been assumed to help prevent future intragroup aggression. However, clear evidence of this beneficial influence is lacking. In fact, few studies have examined between-group differences in the degree of status hierarchy (defined as within-group variation in individual status) and how they are related to bullying, a widespread form of aggression in schools. Data from 11,296 eighth- and ninth-graders (mean age = 14.57, 50.6 % female) from 583 classes in 71 schools were used to determine the direction of the association between classroom degree of status hierarchy and bullying behaviors, and to investigate prospective relationships between these two variables over a 6-month period. Multilevel structural equation modeling analyses showed that higher levels of classroom status hierarchy were concurrently associated with higher levels of bullying at the end of the school year. Higher hierarchy in the middle of the school year predicted higher bullying later in the year. No evidence was found to indicate that initial bullying predicted future hierarchy. These findings highlight the importance of a shared balance of power in the classroom for the prevention of bullying among adolescents.

  20. Structural and biochemical analysis of a unique phosphatase from Bdellovibrio bacteriovorus reveals its structural and functional relationship with the protein tyrosine phosphatase class of phytase.

    Directory of Open Access Journals (Sweden)

    Robert J Gruninger

    Full Text Available Bdellovibrio bacteriovorus is an unusual δ-proteobacterium that invades and preys on other Gram-negative bacteria and is of potential interest as a whole cell therapeutic against pathogens of man, animals and crops. PTPs (protein tyrosine phosphatases are an important class of enzyme involved in desphosphorylating a variety of substrates, often with implications in cell signaling. The B. bacteriovorus open reading frame Bd1204 is predicted to encode a PTP of unknown function. Bd1204 is both structurally and mechanistically related to the PTP-like phytase (PTPLP class of enzymes and possesses a number of unique properties not observed in any other PTPLPs characterized to date. Bd1204 does not display catalytic activity against some common protein tyrosine phosphatase substrates but is highly specific for hydrolysis of phosphomonoester bonds of inositol hexakisphosphate. The structure reveals that Bd1204 has the smallest and least electropositive active site of all characterized PTPLPs to date yet possesses a unique substrate specificity characterized by a strict preference for inositol hexakisphosphate. These two active site features are believed to be the most significant contributors to the specificity of phytate degrading enzymes. We speculate that Bd1204 may be involved in phosphate acquisition outside of prey.

  1. A Hierarchy of Integrable Lattice Soliton Equations and New Integrable Symplectic Map

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Starting from a discrete spectral problem, a hierarchy of integrable lattice soliton equations is derived. It is shown that the hierarchy is completely integrable in the Liouville sense and possesses discrete bi-Hamiltonian structure.A new integrable symplectic map and finite-dimensional integrable systems are given by nonlinearization method. The binary Bargmann constraint gives rise to a B(a)cklund transformation for the resulting integrable lattice equations. At last, conservation laws of the hierarchy are presented.

  2. Cascade Hierarchy in SUSY SU(5) GUT

    CERN Document Server

    Kojima, Kentaro; Takahashi, Ryo

    2010-01-01

    We study cascade hierarchy in supersymmetric SU(5) grand unified theory. The neutrino Dirac mass matrix of the cascade form can lead to the tri-bimaximal generation mixing at the leading order in the seesaw mechanism while the down quark mass matrix of a hybrid cascade form naturally gives the CKM structure. We embed such experimentally favored mass textures into supersymmetric SU(5) GUT, which gives a relation between the down quark and charged lepton mass matrices. Related phenomenologies, such as lepton flavor violating processes and leptogenesis, are also investigated in addition to lepton mixing angles.

  3. Three New Integrable Hierarchies of Equations

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A general Lie algebra Vs and the corresponding loop algebra ~Vs are constructed, from which the linear isospectral Lax pairs are established, whose compatibility presents the zero curvature equation. As its application, a new Lax integrable hierarchy containing two parameters is worked out. It is not Liouville-integrable, however, its two reduced systems are Liouville-integrable, whose Hamiltonian structures are derived by making use of the quadratic-form identity and the γ formula (i.e. the computational formula on the constant γ appeared in the trace identity and the quadratic-form identity).

  4. An Improved Collision Detection Algorithm Based on Dynamic OBB Hierarchy Structure%一种改进的动态OBB层次结构碰撞算法

    Institute of Scientific and Technical Information of China (English)

    黄松柏

    2011-01-01

    在虚拟场景中普遍采用基于OBB包围盒的碰撞检测技术,然而传统算法对于大数据量模型的检测仍然效率不高,难以保证实时性.在分析了OBB及其改进算法的基础上,采用改进的OBB中心计算方法,使包围盒能够更紧密的包围模型,提高碰撞检测的准确性和时间效率.在碰撞检测过程中动态地建立OBB层次结构,减少了时间复杂度和空间复杂度.分析和实验结果证明,改进后的算法在处理一般曲面模型尤其是大数据曲面模型时,碰撞检测的稳定性和效率都有明显提高.%The collision detection algorithm based on the orientation bounding box (OBB) is widely used in the virtual environment, but the traditional algorithm has low efficiency while processing the large surface models, and can't guarantees the real-time performance. An improved algorithm was developed based on a new method that computes the centre of the orientation bounding box, which ensures the bounding box enclosing the model more closely and improves the accuracy and time efficiency of collision detection. By using the algorithm, the OBB hierarchy tree can be built dynamically while collision detecting, and thus the time cost and memory cost could be decreased. The theoretical analysis and experiments prove that the improved algorithm enhances the stability and efficiency obviously while processing the collision detection of large surface models.

  5. Approximation Limits of Linear Programs (Beyond Hierarchies)

    CERN Document Server

    Braun, Gábor; Pokutta, Sebastian; Steurer, David

    2012-01-01

    We develop a framework for approximation limits of polynomial-size linear programs from lower bounds on the nonnegative ranks of suitably defined matrices. This framework yields unconditional impossibility results that are applicable to any linear program as opposed to only programs generated by hierarchies. Using our framework, we prove that O(n^{1/2-eps})-approximations for CLIQUE require linear programs of size 2^{n^\\Omega(eps)}. (This lower bound applies to linear programs using a certain encoding of CLIQUE as a linear optimization problem.) Moreover, we establish a similar result for approximations of semidefinite programs by linear programs. Our main ingredient is a quantitative improvement of Razborov's rectangle corruption lemma for the high error regime, which gives strong lower bounds on the nonnegative rank of certain perturbations of the unique disjointness matrix.

  6. Assessment of Personal Goal Hierarchies.

    Science.gov (United States)

    Wadsworth, Marlene; Ford, Donald H.

    1983-01-01

    Developed a new method for measuring goal hierarchies, called the Adult Intentional and Motivational Systems Chart, by interviewing 53 men and constructing a system summarizing their goals. Results suggested the continued use of the chart for research on self-direction and adult development as well as intervention. (LLL)

  7. Maslow's Hierarchy and Student Retention.

    Science.gov (United States)

    Brookman, David M.

    1989-01-01

    Abraham Maslow's hierarchy of needs offers perspective on student motivation and a rationale for college retention programing. Student affairs and faculty interventions addressing student safety needs and engaging students' sense of purpose reinforce persistence. A mentor program is a possible cooperative effort between student personnel and…

  8. Combinatorial solutions to integrable hierarchies

    OpenAIRE

    Kazarian, M.; Lando, S.

    2015-01-01

    We give a review of modern approaches to constructing formal solutions to integrable hierarchies of mathematical physics, whose coefficients are answers to various enumerative problems. The relationship between these approaches and combinatorics of symmetric groups and their representations is explained. Applications of the results to constructing efficient computations in problems related to models of quantum field theories are given.

  9. Dressing Technique for Intermediate Hierarchies

    OpenAIRE

    Holod, P.; Pakuliak, S.

    1994-01-01

    A generalized AKNS systems introduced and discussed recently in \\cite{dGHM} are considered. It was shown that the dressing technique both in matrix pseudo-differential operators and formal series with respect to the spectral parameter can be developed for these hierarchies.

  10. Maslow's Hierarchy and Student Retention.

    Science.gov (United States)

    Brookman, David M.

    1989-01-01

    Abraham Maslow's hierarchy of needs offers perspective on student motivation and a rationale for college retention programing. Student affairs and faculty interventions addressing student safety needs and engaging students' sense of purpose reinforce persistence. A mentor program is a possible cooperative effort between student personnel and…

  11. Quark masses without Yukawa hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Fanchiotti, H.; Garcia-Canal, C. [Plata Univ. Nacional, Laboratorio de Fisica Teorica, Dept. de Fisica, Facultad de Ciencias Exactas, La Plata (Argentina); Ponce, W.A. [Antioquia Univ., Instituto de Fisica, Colombia La (Argentina)

    2005-12-15

    A model based on the local gauge group SU(3){sub c}*SU(3){sub L}*U(1){sub X} without particles with exotic electric charges is shown to be able to provide the quark mass spectrum and their mixing, by means of universal see-saw mechanisms, avoiding a hierarchy in the Yukawa coupling constants. (authors)

  12. Scale Space Hierarchy

    NARCIS (Netherlands)

    Kuijper, Arjan; Florack, L.M.J.; Viergever, M.A.

    2002-01-01

    We investigate the deep structure of a scale space image. We concentrate on scale space critical points - points with vanishing gradient with respect to both spatial and scale direction. We show that these points are always saddle points. They turn out to be extremely useful, since the iso-intensity

  13. Unique transcriptome patterns of the white and grey matter corroborate structural and functional heterogeneity in the human frontal lobe.

    Directory of Open Access Journals (Sweden)

    James D Mills

    Full Text Available The human frontal lobe has undergone accelerated evolution, leading to the development of unique human features such as language and self-reflection. Cortical grey matter and underlying white matter reflect distinct cellular compositions in the frontal lobe. Surprisingly little is known about the transcriptomal landscape of these distinct regions. Here, for the first time, we report a detailed transcriptomal profile of the frontal grey (GM and white matter (WM with resolution to alternatively spliced isoforms obtained using the RNA-Seq approach. We observed more vigorous transcriptome activity in GM compared to WM, presumably because of the presence of cellular bodies of neurons in the GM and RNA associated with the nucleus and perinuclear space. Among the top differentially expressed genes, we also identified a number of long intergenic non-coding RNAs (lincRNAs, specifically expressed in white matter, such as LINC00162. Furthermore, along with confirmation of expression of known markers for neurons and oligodendrocytes, we identified a number of genes and splicing isoforms that are exclusively expressed in GM or WM with examples of GABRB2 and PAK2 transcripts, respectively. Pathway analysis identified distinct physiological and biochemical processes specific to grey and white matter samples with a prevalence of synaptic processes in GM and myelination regulation and axonogenesis in the WM. Our study also revealed that expression of many genes, for example, the GPR123, is characterized by isoform switching, depending in which structure the gene is expressed. Our report clearly shows that GM and WM have perhaps surprisingly divergent transcriptome profiles, reflecting distinct roles in brain physiology. Further, this study provides the first reference data set for a normal human frontal lobe, which will be useful in comparative transcriptome studies of cerebral disorders, in particular, neurodegenerative diseases.

  14. Preferred hierarchy scales from the product landscape

    OpenAIRE

    Songlin Lv; Zheng Sun; Lina Wu

    2014-01-01

    The product landscape method has been recently proposed to solve hierarchy problems such as the cosmological constant problem. We suggest that the parameter distribution on logarithmic scales should be used as a benchmark for hierarchy, and the preferred hierarchy scales can be obtained from the distribution peak. It is shown that generating hierarchy from purely product distribution is very inefficient. To achieve a reasonably acceptable efficiency, other effects such as accumulation of weak...

  15. Structure and reactivity of a unique Y-shaped tricoordinate bis(silyl)platinum(II)-NHC complex

    NARCIS (Netherlands)

    Berthon-Gelloz, G.; de Bruin, B.; Tinant, B.; Markó, I.E.

    2009-01-01

    A unique, three-coordinate Y-shaped bis(silyl)platinum(II) complex was isolated and characterized. DFT studies on a model system shed light on the nature of this unusual coordination mode for platinum(II).

  16. Two principles of organization in the prefrontal cortex are cognitive hierarchy and degree of automaticity.

    Science.gov (United States)

    Jeon, Hyeon-Ae; Friederici, Angela D

    2013-01-01

    The lateral prefrontal cortex is known to be organized by cognitive hierarchies following a posterior-to-anterior gradient. Here we test whether this model applies across different cognitive domains by varying levels of cognitive hierarchy in first language, second language and non-language domains. These domains vary in their degree of automaticity with first language being the most automatic. For second language/non-language a clear gradient pattern of activation depending on the level of hierarchy is observed in the prefrontal cortex with the highest level of hierarchy recruiting its most anterior region, whereas for first language the highest level of hierarchy recruits its most posterior region. Moreover, second language/non-language and first language differ in the structural connectivity of their underlying networks. The current data strongly suggest that functional segregation of the prefrontal cortex is determined by cognitive hierarchy and the degree of automaticity.

  17. Hierarchy in directed random networks: analytical and numerical results

    CERN Document Server

    Mones, Enys

    2012-01-01

    In recent years, the theory and application of complex networks has been quickly developing in a markable way due to the increasing amount of data from real systems and to the fruitful application of powerful methods used in statistical physics. Many important characteristics of social or biological systems can be described by the study of their underlying structure of interactions. Hierarchy is one of these features that can be formulated in the language of networks. In this paper we present the analytic results on the hierarchical properties of random network models with zero correlations and also investigate the effects of different type of correlations. The behavior of hierarchy is different in the absence and the presence of the giant components. We show that the hierarchical structure can be drastically different if there are one-point correlations in the network. We also show numerical results suggesting that hierarchy does not change monotonously with the correlations and there is an optimal level of ...

  18. Reductions of Lower Triangular Toda Hierarchies

    NARCIS (Netherlands)

    Helminck, G.F.; Mishina, Marina G.; Polenkova, Svetlana V.

    2007-01-01

    Deforming commutative algebras in the lower triangular (ℤ×ℤ)-matrices yields lower triangular Toda hierarchies and their associated nonlinear equations. Like for their counterpart in the ring of pseudodifferential operators, the KP-hierarchy, one also has for these hierarchies a geometric picture:

  19. On a Schwarzian PDE associated with the KdV Hierarchy

    CERN Document Server

    Nijhoff, F W; Joshi, N; Nijhoff, Frank; Hone, Andrew; Joshi, Nalini

    1999-01-01

    We present a novel integrable non-autonomous partial differential equation of the Schwarzian type, i.e. invariant under Möbius transformations, that is related to the Korteweg-de Vries hierarchy. In fact, this PDE can be considered as the generating equation for the entire hierarchy of Schwarzian KdV equations. We present its Lax pair, establish its connection with the SKdV hierarchy, its Miura relations to similar generating PDEs for the modified and regular KdV hierarchies and its Lagrangian structure. Finally we demonstrate that its similarity reductions lead to the {\\it full} Painlevé VI equation, i.e. with four arbitary parameters.

  20. Hierarchy in inorganic membranes.

    Science.gov (United States)

    Caro, Juergen

    2016-06-13

    Thin films of a few μm thickness for particle filtration and gas separation cannot be applied as self-supporting layers since they are mechanically insufficiently strong. Therefore, these top layers for particle filtration and gas separation are usually deposited on porous mechanically strong supports with a hierarchical pore structure. To reduce the pressure drop of a gas stream over the membrane and to ensure high fluxes in filtration and gas separation, the cross section of the support is usually asymmetric or graded with a small thickness of the layer with the smallest pore size called the top layer. Since the pressure drop over a capillary with radius r is ∼r(4), the layer with the smallest pore size should be as thin as possible. The disk-like planar supports are usually prepared by sequential tape casting which is an expensive technology. Tubular supports with a hierarchical cross section can be prepared in one step by hollow fiber spinning, double mantle spinning or centrifugal casting.

  1. The unique architecture and function of cellulose-interacting proteins in oomycetes revealed by genomic and structural analyses

    Directory of Open Access Journals (Sweden)

    Larroque Mathieu

    2012-11-01

    Full Text Available Abstract Background Oomycetes are fungal-like microorganisms evolutionary distinct from true fungi, belonging to the Stramenopile lineage and comprising major plant pathogens. Both oomycetes and fungi express proteins able to interact with cellulose, a major component of plant and oomycete cell walls, through the presence of carbohydrate-binding module belonging to the family 1 (CBM1. Fungal CBM1-containing proteins were implicated in cellulose degradation whereas in oomycetes, the Cellulose Binding Elicitor Lectin (CBEL, a well-characterized CBM1-protein from Phytophthora parasitica, was implicated in cell wall integrity, adhesion to cellulosic substrates and induction of plant immunity. Results To extend our knowledge on CBM1-containing proteins in oomycetes, we have conducted a comprehensive analysis on 60 fungi and 7 oomycetes genomes leading to the identification of 518 CBM1-containing proteins. In plant-interacting microorganisms, the larger number of CBM1-protein coding genes is expressed by necrotroph and hemibiotrophic pathogens, whereas a strong reduction of these genes is observed in symbionts and biotrophs. In fungi, more than 70% of CBM1-containing proteins correspond to enzymatic proteins in which CBM1 is associated with a catalytic unit involved in cellulose degradation. In oomycetes more than 90% of proteins are similar to CBEL in which CBM1 is associated with a non-catalytic PAN/Apple domain, known to interact with specific carbohydrates or proteins. Distinct Stramenopile genomes like diatoms and brown algae are devoid of CBM1 coding genes. A CBM1-PAN/Apple association 3D structural modeling was built allowing the identification of amino acid residues interacting with cellulose and suggesting the putative interaction of the PAN/Apple domain with another type of glucan. By Surface Plasmon Resonance experiments, we showed that CBEL binds to glycoproteins through galactose or N-acetyl-galactosamine motifs. Conclusions This study

  2. Measuring Maslow's hierarchy of needs.

    Science.gov (United States)

    Lester, David

    2013-08-01

    Two scales have been proposed to measure Maslow's hierarchy of needs in college students, one by Lester (1990) and one by Strong and Fiebert (1987). In a sample of 51 college students, scores on the corresponding scales for the five needs did not correlate significantly and positively, except for the measures of physiological needs. Furthermore, there was limited support for Maslow's hypothesis that need deprivation would predict psychopathology (specifically, mania and depression).

  3. The stochastic integrable AKNS hierarchy

    OpenAIRE

    Arnaudon, Alexis

    2015-01-01

    We derive a stochastic AKNS hierarchy using geometrical methods. The integrability is shown via a stochastic zero curvature relation associated with a stochastic isospectral problem. We expose some of the stochastic integrable partial differential equations which extend the stochastic KdV equation discovered by M. Wadati in 1983 for all the AKNS flows. We also show how to find stochastic solitons from the stochastic evolution of the scattering data of the stochastic IST. We finally expose som...

  4. KP hierarchy for Hodge integrals

    OpenAIRE

    Kazarian, M.

    2008-01-01

    Starting from the ELSV formula, we derive a number of new equations on the generating functions for Hodge integrals over the moduli space of complex curves. This gives a new simple and uniform treatment of certain known results on Hodge integrals like Witten's conjecture, Virasoro constrains, Faber's lambda_g conjecture etc. Among other results we show that a properly arranged generating function for Hodge integrals satisfies the equations of the KP hierarchy.

  5. Combinatorial solutions to integrable hierarchies

    Science.gov (United States)

    Kazarian, M. E.; Lando, S. K.

    2015-06-01

    This paper reviews modern approaches to the construction of formal solutions to integrable hierarchies of mathematical physics whose coefficients are answers to various enumerative problems. The relationship between these approaches and the combinatorics of symmetric groups and their representations is explained. Applications of the results to the construction of efficient computations in problems related to models of quantum field theories are described. Bibliography: 34 titles.

  6. Solving the Wrong Hierarchy Problem

    CERN Document Server

    Blinov, Nikita

    2016-01-01

    Many theories require augmenting the Standard Model with additional scalar fields with large order one couplings. We present a new solution to the hierarchy problem for these scalar fields. We explore parity- and $\\mathbb{Z}_2$-symmetric theories where the Standard Model Higgs potential has two vacua. The parity or $\\mathbb{Z}_2$ copy of the Higgs lives in the minimum far from the origin while our Higgs occupies the minimum near the origin of the potential. This approach results in a theory with multiple light scalar fields but with only a single hierarchy problem, since the bare mass is tied to the Higgs mass by a discrete symmetry. The new scalar does not have a new hierarchy problem associated with it because its expectation value and mass are generated by dimensional transmutation of the scalar quartic coupling. The location of the second Higgs minimum is not a free parameter, but is rather a function of the matter content of the theory. As a result, these theories are extremely predictive. We develop thi...

  7. Solving the wrong hierarchy problem

    Science.gov (United States)

    Blinov, Nikita; Hook, Anson

    2016-06-01

    Many theories require augmenting the Standard Model with additional scalar fields with large order one couplings. We present a new solution to the hierarchy problem for these scalar fields. We explore parity- and Z_2 -symmetric theories where the Standard Model Higgs potential has two vacua. The parity or Z_2 copy of the Higgs lives in the minimum far from the origin while our Higgs occupies the minimum near the origin of the potential. This approach results in a theory with multiple light scalar fields but with only a single hierarchy problem, since the bare mass is tied to the Higgs mass by a discrete symmetry. The new scalar does not have a new hierarchy problem associated with it because its expectation value and mass are generated by dimensional transmutation of the scalar quartic coupling. The location of the second Higgs minimum is not a free parameter, but is rather a function of the matter content of the theory. As a result, these theories are extremely predictive. We develop this idea in the context of a solution to the strong CP problem. We show this mechanism postdicts the top Yukawa to be within 1 σ of the currently measured value and predicts scalar color octets with masses in the range 9-200 TeV.

  8. Headwater biodiversity among different levels of stream habitat hierarchy

    DEFF Research Database (Denmark)

    Göthe, Emma; Friberg, Nikolai; Kahlert, Maria

    2014-01-01

    of a- and b-diversity to y-diversity between two levels of stream habitat hierarchy (catchment and region level). The relationship between species community structure and local environmental factors was also assessed. Our results show that both a- and b-diversity made a significant contribution to y......-diversity. b-diversity remained relatively constant between the two levels of habitat hierarchy even though local environmental control of the biota decreased from the catchment to the region level. To capture most of headwater y-diversity, management should therefore target sites that are locally diverse...

  9. Structural and functional studies on a unique linear neutralizing antigenic site (G5) of the rabies virus glycoprotein.

    NARCIS (Netherlands)

    R.W.J. van der Heijden (Roger); J.P.M. Langedijk; J. Groen (Jan); F.G.C.M. Uytdehaag (Fons); R.H. Meloen; A.D.M.E. Osterhaus (Albert)

    1993-01-01

    textabstractThe core of a unique linear neutralization epitope (G5) on the glycoprotein of rabies virus, recognized by a virus-neutralizing mouse monoclonal antibody (MAb 6-15C4), was determined by Pepscan analysis. The G5 epitope was defined as an octapeptide (LHDFRSDE). The contribution of the

  10. Hierarchy-Direction Selective Approach for Locally Adaptive Sparse Grids

    Energy Technology Data Exchange (ETDEWEB)

    Stoyanov, Miroslav K [ORNL

    2013-09-01

    We consider the problem of multidimensional adaptive hierarchical interpolation. We use sparse grids points and functions that are induced from a one dimensional hierarchical rule via tensor products. The classical locally adaptive sparse grid algorithm uses an isotropic refinement from the coarser to the denser levels of the hierarchy. However, the multidimensional hierarchy provides a more complex structure that allows for various anisotropic and hierarchy selective refinement techniques. We consider the more advanced refinement techniques and apply them to a number of simple test functions chosen to demonstrate the various advantages and disadvantages of each method. While there is no refinement scheme that is optimal for all functions, the fully adaptive family-direction-selective technique is usually more stable and requires fewer samples.

  11. Unique Structural Properties of the Mg-Al Hydrotalcite Solid Base Catalyst : An In Situ Study using Mg and Al K-edge XAFS during Calcination and Rehydration

    NARCIS (Netherlands)

    Koningsberger, D.C.; Bokhoven, J.A. van; Roelofs, J.C.A.A.; Jong, K.P. de

    2001-01-01

    The changes in the layered structure of Mg-Al hydrotalcite (Mg/Al=2) during heat treatment have been investigated by using in situ XAFS simultaneously at the Mg and Al K-edges. The development of unique in situ instrumentation allowed the coordination environments at both the Mg and Al centers to be

  12. Structural aesthetics in molecular nanoscience: a unique Ni26 cluster with a 'rabbit-face' topology and a discrete Ni18 'molecular chain'.

    Science.gov (United States)

    Athanasopoulou, Angeliki A; Pilkington, Melanie; Raptopoulou, Catherine P; Escuer, Albert; Stamatatos, Theocharis C

    2014-12-11

    The use of a previously unexplored Schiff-base ligand in Ni(II) carboxylate chemistry has afforded a Ni26 cluster with a record nuclearity that crystallizes with a unique 'rabbit-face'-like topology, and a Ni18 compound that adopts an unusual 'molecular chain' structure.

  13. Cortical hierarchy governs rat claustrocortical circuit organization.

    Science.gov (United States)

    White, Michael G; Cody, Patrick A; Bubser, Michael; Wang, Hui-Dong; Deutch, Ariel Y; Mathur, Brian N

    2017-04-15

    The claustrum is a telencephalic gray matter structure with various proposed functions, including sensory integration and attentional allocation. Underlying these concepts is the reciprocal connectivity of the claustrum with most, if not all, areas of the cortex. What remains to be elucidated to inform functional hypotheses further is whether a pattern exists in the strength of connectivity between a given cortical area and the claustrum. To this end, we performed a series of retrograde neuronal tract tracer injections into rat cortical areas along the cortical processing hierarchy, from primary sensory and motor to frontal cortices. We observed that the number of claustrocortical projections increased as a function of processing hierarchy; claustrum neurons projecting to primary sensory cortices were scant and restricted in distribution across the claustrum, whereas neurons projecting to the cingulate cortex were densely packed and more evenly distributed throughout the claustrum. This connectivity pattern suggests that the claustrum may preferentially subserve executive functions orchestrated by the cingulate cortex. J. Comp. Neurol. 525:1347-1362, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  14. Modeling rises and falls in money addicted social hierarchies

    DEFF Research Database (Denmark)

    Dybiec, Bartłomiej; Mitarai, Namiko; Sneppen, Kim

    2014-01-01

    ambition by modeling the interplay of social networking and an uneven distribution of external resources. The model naturally generates social hierarchies. Remarkably, this social structure exhibits a rise-and-fall behavior. A well pronounced quasi-periodic dynamics, which is closely associated...

  15. Separation and quantification of underwater structural vibration and noise sources based on hierarchy diagnosis%基于层次诊断的水下结构振动噪声源分离量化

    Institute of Scientific and Technical Information of China (English)

    时胜国; 于树华; 韩闯; 时洁

    2014-01-01

    From acoustic point of view,a submarine has features,such as,numerous vibration and noise sources, serious coupling among them and complex transmission paths.Hierarchy diagnosis can be used to solve the problem of vibration and noise source separation and quantification by constructing a hierarchical structure,and the dominance relationship is formed from top to bottom.By means of scale,the vibration and noise source's contribution is obtained by pairwise comparison.Here,according to the decibel addition principle,the AHP comparison scale was adjusted to have physical significance,and the results of hierarchy diagnosis become the measure with actual physical significance.The hierarchy diagnosis procedure of a submarine was divided into two links including from an equipment inside the submarine to the submarine shell and the shell to the outside underwater acoustic field.The results were fused using the weighted average method and the D-S evidence theory.The feasibility of this method was validated with simulations and cabin tests.%从声学的角度看,潜艇具有振动噪声源数目众多、相互之间耦合严重以及传递路径复杂的特点。层次诊断通过建立递阶层次结构对振动噪声源分离量化问题进行分解,从而形成了自上而下的支配关系,然后借助于标度通过两两比较建立判断矩阵,从而得到各振动噪声源对评价点的贡献量。根据声学中的分贝数相加原理,对层次分析法中的标度进行调整使其具有物理意义,从而使层次诊断结果是具有实际物理意义的测度。将潜艇层次诊断过程分为两个环节,分别为从艇内设备到壳体以及从壳体到水声场,并采用加权平均方法和D-S证据理论对这两个环节的计算结果进行融合。仿真计算和舱段试验验证了层次诊断应用到舱段模型振动噪声源分离量化问题中的可行性。

  16. Theory on Structure and Coloring of Maximal Planar Graphs (3)Purely Tree-colorable and Uniquely 4-colorable Maximal Planar Graph Conjectures

    Institute of Scientific and Technical Information of China (English)

    XU Jin

    2016-01-01

    A maximal planar graph is called the recursive maximal planar graph if it can be obtained from 4 K by embedding a 3-degree vertex in some triangular face continuously. The uniquely 4-colorable maximal planar graph conjecture states that a planar graph is uniquely 4-colorable if and only if it is a recursive maximal planar graph. This conjecture, which has 43 years of history, is a very influential conjecture in graph coloring theory after the Four-Color Conjecture. In this paper, the structures and properties of dumbbell maximal planar graphs and recursive maximal planar graphs are studied, and an idea of proving the uniquely 4-colorable maximal planar graph conjecture is proposed based on the extending-contracting operation proposed in this series of article (2).

  17. Multi-Core Cache Hierarchies

    CERN Document Server

    Balasubramonian, Rajeev

    2011-01-01

    A key determinant of overall system performance and power dissipation is the cache hierarchy since access to off-chip memory consumes many more cycles and energy than on-chip accesses. In addition, multi-core processors are expected to place ever higher bandwidth demands on the memory system. All these issues make it important to avoid off-chip memory access by improving the efficiency of the on-chip cache. Future multi-core processors will have many large cache banks connected by a network and shared by many cores. Hence, many important problems must be solved: cache resources must be allocat

  18. Emergent Power Hierarchies and Group Performance.

    Science.gov (United States)

    Frauendorfer, Denise; Schmid Mast, Marianne; Sanchez-Cortes, Dairazalia; Gatica-Perez, Daniel

    2015-10-01

    In newly formed groups, informal hierarchies emerge automatically and readily. In this study, we argue that emergent group hierarchies enhance group performance (Hypothesis 1) and we assume that the more the power hierarchy within a group corresponds to the task-competence differences of the individual group members, the better the group performs (Hypothesis 2). Twelve three-person groups and 28 four-person groups were investigated while solving the Winter Survival Task. Results show that emerging power hierarchies positively impact group performance but the alignment between task-competence and power hierarchy did not affect group performance. Thus, emergent power hierarchies are beneficial for group performance and although they were on average created around individual group members' competence, this correspondence was not a prerequisite for better group performance.

  19. Predictability and hierarchy in Drosophila behavior

    CERN Document Server

    Berman, Gordon J; Shaevitz, Joshua W

    2016-01-01

    Even the simplest of animals exhibit behavioral sequences with complex temporal dynamics. Prominent amongst the proposed organizing principles for these dynamics has been the idea of a hierarchy, wherein the movements an animal makes can be understood as a set of nested sub-clusters. Although this type of organization holds potential advantages in terms of motion control and neural circuitry, measurements demonstrating this for an animal's entire behavioral repertoire have been limited in scope and temporal complexity. Here, we use a recently developed unsupervised technique to discover and track the occurrence of all stereotyped behaviors performed by fruit flies moving in a shallow arena. Calculating the optimally predictive representation of the fly's future behaviors, we show that fly behavior exhibits multiple time scales and is organized into a hierarchical structure that is indicative of its underlying behavioral programs and its changing internal states.

  20. Lax operator algebras and Hamiltonian integrable hierarchies

    CERN Document Server

    Sheinman, Oleg K

    2009-01-01

    We consider the theory of Lax equations in complex simple and reductive classical Lie algebras with the spectral parameter on a Riemann surface of finite genus. Our approach is based on the new objects -- the Lax operator algebras, and develops the approach of I.Krichever treating the $\\gl(n)$ case. For every Lax operator considered as the mapping sending a point of the cotangent bundle on the space of extended Tyrin data to an element of the corresponding Lax operator algebra we construct the hierarchy of mutually commuting flows given by Lax equations and prove that those are Hamiltonian with respect to the Krichever-Phong symplectic structure. The corresponding Hamiltonians give integrable finite-dimensional Hitchin-type systems. For example we derive elliptic $A_n$, $C_n$, $D_n$ Calogero-Moser systems in frame of our approach.

  1. Lax operator algebras and Hamiltonian integrable hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Sheinman, Oleg K [Steklov Mathematical Institute, Russian Academy of Sciences, Moscow (Russian Federation)

    2011-02-28

    This paper considers the theory of Lax equations with a spectral parameter on a Riemann surface, proposed by Krichever in 2001. The approach here is based on new objects, the Lax operator algebras, taking into consideration an arbitrary complex simple or reductive classical Lie algebra. For every Lax operator, regarded as a map sending a point of the cotangent bundle on the space of extended Tyurin data to an element of the corresponding Lax operator algebra, a hierarchy of mutually commuting flows given by the Lax equations is constructed, and it is proved that they are Hamiltonian with respect to the Krichever-Phong symplectic structure. The corresponding Hamiltonians give integrable finite-dimensional Hitchin-type systems. For example, elliptic A{sub n}, C{sub n}, and D{sub n} Calogero-Moser systems are derived in the framework of our approach. Bibliography: 13 titles.

  2. Optimal Organizational Hierarchies: Source Coding: Disaster Relief

    CERN Document Server

    Murthy, G Rama

    2011-01-01

    ulticasting is an important communication paradigm for enabling the dissemination of information selectively. This paper considers the problem of optimal secure multicasting in a communication network captured through a graph (optimal is in an interesting sense) and provides a doubly optimal solution using results from source coding. It is realized that the solution leads to optimal design (in a well defined optimality sense) of organizational hierarchies captured through a graph. In this effort two novel concepts : prefix free path, graph entropy are introduced. Some results of graph entropy are provided. Also some results on Kraft inequality are discussed. As an application Hierarchical Hybrid Communication Network is utilized as a model of structured Mobile Adhoc network for utility in Disaster Management. Several new research problems that naturally emanate from this research are summarized.

  3. Triple-stranded ferric helices: a π-π interaction-driven structural hierarchy of Fe5, Fe7, and Fe17 clusters.

    Science.gov (United States)

    Shiga, Takuya; Noguchi, Mao; Sato, Hiroki; Matsumoto, Takuto; Newton, Graham N; Oshio, Hiroki

    2013-12-07

    Three polypyridine ligand-supported multinuclear iron complexes, [Fe5], [Fe7] and [Fe17], were synthesized and their physical properties were investigated. The complexes had triple-stranded helical structures with pseudo threefold symmetry, and were stabilized by varying degrees of intramolecular π-π stacking. The pentanuclear iron complex consisted of two Fe(II) and three Fe(III) ions, supported by three ligands, while the heptanuclear complex comprised four Fe(II) centres, three Fe(III) ions, and six ligands, and the heptadecanuclear complex contained seventeen Fe(III) ions and nine ligands. Electrochemical studies revealed that the pentanuclear and heptanuclear iron complexes showed pseudo-reversible three- and five-step redox behaviours, respectively. Magnetic measurements conducted on the pentanuclear and heptanuclear complexes revealed that antiferromagnetic interactions were operative between neighbouring iron ions through the oxo- and pyrazole-bridges.

  4. Fine Structure in the Circumstellar Environment of a Young, Solar-like Star the Unique Eclipses of KH 15D

    CERN Document Server

    Herbst, W; Vrba, F J; Ibrahimov, M A; Bailer-Jones, C A L; Mundt, R; Lamm, M J; Mazeh, T; Webster, Z T; Haisch, K E; Williams, E C; Rhodes, A H; Balonek, T J; Riffeser, A; Herbst, William; Hamilton, Catrina M.; Vrba, Frederick J.; Ibrahimov, Mansur A.; Bailer-Jones, Coryn A.L.; Mundt, Reinhard; Lamm, Markus; Mazeh, Tsevi; Webster, Zodiac T.; Haisch, Karl E.; Williams, Eric C.; Rhodes, Andrew H.; Balonek, Thomas J.; Riffeser, Alexander Scholz and Arno

    2002-01-01

    Results of an international campaign to photometrically monitor the unique pre-main sequence eclipsing object KH 15D are reported. An updated ephemeris for the eclipse is derived that incorporates a slightly revised period of 48.36 d. There is some evidence that the orbital period is actually twice that value, with two eclipses occurring per cycle. The extraordinary depth (~3.5 mag) and duration (~18 days) of the eclipse indicate that it is caused by circumstellar matter, presumably the inner portion of a disk. The eclipse has continued to lengthen with time and the central brightness reversals are not as extreme as they once were. V-R and V-I colors indicate that the system is slightly bluer near minimum light. Ingress and egress are remarkably well modeled by the passage of a knife-edge across a limb-darkened star. Possible models for the system are briefly discussed.

  5. Interconvertions between delta-lactam and delta-lactone derivatives initiated by unique transannular interactions of the rigid cyclohexane boat structure in pentacycloundecane.

    Science.gov (United States)

    Kruger, Hendrik G; Martins, Frans J C; Viljoen, Agatha M

    2004-07-09

    The pentacycloundecane (PCU) cage structure resembles a perfect boat conformation, and for the first time unique lactam/lactone interconversions on the flagpole carbons of a cyclohexane boat structure are reported. The syntheses of a novel dihydroxy-PCU-delta-lactone and two novel N-substituted PCU-delta-lactams are reported. Hydrolysis of some of the PCU-delta-lactam compounds produced delta-lactones, and reaction of the lactones with ammonia or primary amines again produced delta-lactams. Reaction mechanisms to account for the unusual interconversion reactions induced by transannular interactions are proposed.

  6. The Structure of the Poxvirus A33 Protein Reveals a Dimer of Unique C-Type Lectin-Like Domains

    Energy Technology Data Exchange (ETDEWEB)

    Su, Hua-Poo; Singh, Kavita; Gittis, Apostolos G.; Garboczi, David N. (NIH)

    2010-11-03

    The current vaccine against smallpox is an infectious form of vaccinia virus that has significant side effects. Alternative vaccine approaches using recombinant viral proteins are being developed. A target of subunit vaccine strategies is the poxvirus protein A33, a conserved protein in the Chordopoxvirinae subfamily of Poxviridae that is expressed on the outer viral envelope. Here we have determined the structure of the A33 ectodomain of vaccinia virus. The structure revealed C-type lectin-like domains (CTLDs) that occur as dimers in A33 crystals with five different crystal lattices. Comparison of the A33 dimer models shows that the A33 monomers have a degree of flexibility in position within the dimer. Structural comparisons show that the A33 monomer is a close match to the Link module class of CTLDs but that the A33 dimer is most similar to the natural killer (NK)-cell receptor class of CTLDs. Structural data on Link modules and NK-cell receptor-ligand complexes suggest a surface of A33 that could interact with viral or host ligands. The dimer interface is well conserved in all known A33 sequences, indicating an important role for the A33 dimer. The structure indicates how previously described A33 mutations disrupt protein folding and locates the positions of N-linked glycosylations and the epitope of a protective antibody.

  7. The structural chemistry of metallocorroles: combined X-ray crystallography and quantum chemistry studies afford unique insights.

    Science.gov (United States)

    Thomas, Kolle E; Alemayehu, Abraham B; Conradie, Jeanet; Beavers, Christine M; Ghosh, Abhik

    2012-08-21

    Although they share some superficial structural similarities with porphyrins, corroles, trianionic ligands with contracted cores, give rise to fundamentally different transition metal complexes in comparison with the dianionic porphyrins. Many metallocorroles are formally high-valent, although a good fraction of them are also noninnocent, with significant corrole radical character. These electronic-structural characteristics result in a variety of fascinating spectroscopic behavior, including highly characteristic, paramagnetically shifted NMR spectra and textbook cases of charge-transfer spectra. Although our early research on corroles focused on spectroscopy, we soon learned that the geometric structures of metallocorroles provide a fascinating window into their electronic-structural characteristics. Thus, we used X-ray structure determinations and quantum chemical studies, chiefly using DFT, to obtain a comprehensive understanding of metallocorrole geometric and electronic structures. This Account describes our studies of the structural chemistry of metallocorroles. At first blush, the planar or mildly domed structure of metallocorroles might appear somewhat uninteresting particularly when compared to metalloporphyrins. Metalloporphyrins, especially sterically hindered ones, are routinely ruffled or saddled, but the missing meso carbon apparently makes the corrole skeleton much more resistant to nonplanar distortions. Ruffling, where the pyrrole rings are alternately twisted about the M-N bonds, is energetically impossible for metallocorroles. Saddling is also uncommon; thus, a number of sterically hindered, fully substituted metallocorroles exhibit almost perfectly planar macrocycle cores. Against this backdrop, copper corroles stand out as an important exception. As a result of an energetically favorable Cu(d(x2-y2))-corrole(π) orbital interaction, copper corroles, even sterically unhindered ones, are inherently saddled. Sterically hindered substituents

  8. Ordinal ultrafilters versus P-hierarchy

    CERN Document Server

    Starosolski, Andrzej

    2012-01-01

    An earlier paper, entitled "P-hierarchy on $\\beta\\omega$", investigated the relations between ordinal ultrafilters and the so-called P-hierarchy. This study is continued in the present paper and focuses on the aspects of characterization of classes of finite index, existence, generic existence and the Rudin-Keisler-order.

  9. A Suggested Modification to Maslow's Need Hierarchy

    Science.gov (United States)

    Groves, David L.; And Others

    1975-01-01

    Since its development, Maslow's need hierarchy has been criticized and applauded. This investigation was undertaken to explore a modification of the upper levels of the need hierarchy based upon the application of power, competition, and achievement to self, as well as the concept of "other directed." (Author)

  10. A Suggested Modification to Maslow's Need Hierarchy

    Science.gov (United States)

    Groves, David L.; And Others

    1975-01-01

    Since its development, Maslow's need hierarchy has been criticized and applauded. This investigation was undertaken to explore a modification of the upper levels of the need hierarchy based upon the application of power, competition, and achievement to self, as well as the concept of "other directed." (Author)

  11. Restructuring Large Data Hierarchies for Scientific Query Tools

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, M

    2005-02-08

    Today's large-scale scientific simulations produce data sets tens to hundreds of terabytes in size. The DataFoundry project is developing querying and analysis tools for these data sets. The Approximate Ad-Hoc Query Engine for Simulation Data (AQSIM) uses a multi-resolution, tree-shaped data structure that allows users to place runtime limits on queries over scientific simulation data. In this AQSIM data hierarchy, each node in the tree contains an abstract model describing all of the information contained in the subtree below that node. AQSIM is able to create the data hierarchy in a single pass. However, the nodes in the hierarchy frequently have low node fanout, which leads to inefficient I/O behavior during query processing. Low node fanout is a common problem in tree-shaped indices. This paper presents a set of one-pass tree ''pruning'' algorithms that efficiently restructure the data hierarchy by removing inner nodes, thereby increasing node fanout. As our experimental results show, the best approach is a combination of two algorithms, one that focuses on increasing node fanout and one that attempts to reduce the maximum tree height.

  12. A Bayesian Generative Model for Learning Semantic Hierarchies

    Directory of Open Access Journals (Sweden)

    Roni eMittelman

    2014-05-01

    Full Text Available Building fine-grained visual recognition systems that are capable of recognizing tens of thousands of categories, has received much attention in recent years. The well known semantic hierarchical structure of categories and concepts, has been shown to provide a key prior which allows for optimal predictions. The hierarchical organization of various domains and concepts has been subject to extensive research, and led to the development of the WordNet domains hierarchy [18], which was also used to organize the images in the ImageNet [11] dataset, in which the category count approaches the human capacity. Still, for the human visual system, the form of the hierarchy must be discovered with minimal use of supervision or innate knowledge. In this work, we propose a new Bayesian generative model for learning such domain hierarchies, based on semantic input. Our model is motivated by the super-subordinate organization of domain labels and concepts that characterizes WordNet, and accounts for several important challenges: maintaining context information when progressing deeper into the hierarchy, learning a coherent semantic concept for each node, and modeling uncertainty in the perception process.

  13. A Bayesian generative model for learning semantic hierarchies.

    Science.gov (United States)

    Mittelman, Roni; Sun, Min; Kuipers, Benjamin; Savarese, Silvio

    2014-01-01

    Building fine-grained visual recognition systems that are capable of recognizing tens of thousands of categories, has received much attention in recent years. The well known semantic hierarchical structure of categories and concepts, has been shown to provide a key prior which allows for optimal predictions. The hierarchical organization of various domains and concepts has been subject to extensive research, and led to the development of the WordNet domains hierarchy (Fellbaum, 1998), which was also used to organize the images in the ImageNet (Deng et al., 2009) dataset, in which the category count approaches the human capacity. Still, for the human visual system, the form of the hierarchy must be discovered with minimal use of supervision or innate knowledge. In this work, we propose a new Bayesian generative model for learning such domain hierarchies, based on semantic input. Our model is motivated by the super-subordinate organization of domain labels and concepts that characterizes WordNet, and accounts for several important challenges: maintaining context information when progressing deeper into the hierarchy, learning a coherent semantic concept for each node, and modeling uncertainty in the perception process.

  14. Hierarchy of Modular Graph Identities

    CERN Document Server

    D'Hoker, Eric

    2016-01-01

    The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analy...

  15. Flavor hierarchies from dynamical scales

    CERN Document Server

    Panico, Giuliano

    2016-07-20

    One main obstacle for any beyond the SM (BSM) scenario solving the hierarchy problem is its potentially large contributions to electric dipole moments. An elegant way to avoid this problem is to have the light SM fermions couple to the BSM sector only through bilinears, $\\bar ff$. This possibility can be neatly implemented in composite Higgs models. We study the implications of dynamically generating the fermion Yukawa couplings at different scales, relating larger scales to lighter SM fermions. We show that all flavor and CP-violating constraints can be easily accommodated for a BSM scale of few TeV, without requiring any extra symmetry. Contributions to B physics are mainly mediated by the top, giving a predictive pattern of deviations in $\\Delta F=2$ and $\\Delta F=1$ flavor observables that could be seen in future experiments.

  16. A Preliminary Study on the Value Goal, Structure and Hierarchy of China’s National Governance System%试论我国国家治理体系的价值目标、结构及层次

    Institute of Scientific and Technical Information of China (English)

    高小平; 刘杰

    2015-01-01

    As a set of closely interconnected and mutually coordinated systems, China’s national govern-ance system is the summation of systems, mechanisms, laws and regulations with which the Party guides the peo-ple in order to govern national economy, politics, culture, society and ecological civilization, etc. Based on the theory and practice of national governance, this paper applies governance concepts to value theory, structure the-ory and hierarchy theory, studies the basic principles of establishing the value goal of national governance system, and concludes that the value goal of national governance embodies “One Modernization”, “Three Confidence”, “Five Major Goals” and “Ten Prominent Relations”. The basic structure of national governance system is consti-tuted of values, systems and acts. The governance hierarchy consists of national governance, government govern-ance, social governance and community governance. The political-administrative system is a logic-based multi-layered system formed by ideology, political programs, legal rules, political supervision, organizational personnel, government responsibility, management performance, institution establishment and organizational functions.%我国的国家治理体系,是党领导人民管理国家的政治、经济、文化、社会、生态等各领域的体制、机制和法律法规的总合,是一整套紧密相连、相互协调的国家系统。本文从国家治理理论与实践的结合点出发,将治理理念融入价值理论、结构理论和层次理论,研究确立国家治理体系价值目标的基本原则,进而提出国家治理的价值目标是一个现代化、三个自信、十大关系和五大目标,国家治理体系的基本结构框架是价值、制度与行动组成的系统,国家治理的基本层次是国家治理、政府治理、社会治理、社区治理的梯次系统,政治–行政体系的层次是意识形态、政治纲领、法制规

  17. Normalization of Class Hierarchy in Databases

    Institute of Scientific and Technical Information of China (English)

    李天柱; 肖计田; 等

    1996-01-01

    In complex object oriented databases,the purpose of introducing class hierarchy is to express ISA semantics,to realize inheriting and to reuse schema definition codes.The schema defintition and schema evolution,based on the partial order of lattice,often cause the loss o information inheriting and the redundance of schema definition.Based on the fullness of the inheritance shown by class hierarchy,three normal forms of class hierarchy are given in this paper,and a general algorithm of normalization of class hierarchy is presented,following the Boolean algebra model of class hierarchy.The loss of information inheritance can be avoided when they are applied to schema design and schema evolution.

  18. Is there a hierarchy of survival reflexes?

    Science.gov (United States)

    Macphail, Kieran

    2013-10-01

    A hierarchy of survival reflexes for prioritising assessment and treatment in patients with pain of insidious onset is hypothesised. The hierarchy asserts that some systems are more vital than others and that the central nervous system (CNS) prioritises systems based on their significance to survival. The hypothesis suggests that dysfunction in more important systems will cause compensation in less important systems. This paper presents studies examining these effects for each system, arguing that each section of the hierarchy may have effects on other systems within the hierarchy. This concept is untested empirically, highly speculative and substantial research is required to validate the suggested hierarchical prioritisation by the CNS. Nonetheless, the hierarchy does provide a theoretical framework to use to exclude contributing systems in patients with pain of insidious onset. Copyright © 2013 Elsevier Ltd. All rights reserved.

  19. The recursion operator for a constrained CKP hierarchy

    CERN Document Server

    Li, Chuanzhong; He, Jingsong; Cheng, Yi

    2010-01-01

    This paper gives a recursion operator for a 1-constrained CKP hierarchy, and by the recursion operator it proves that the 1-constrained CKP hierarchy can be reduced to the mKdV hierarchy under condition $q=r$.

  20. The recursion operator for a constrained CKP hierarchy

    OpenAIRE

    Li, Chuanzhong; Tian, Kelei; He, Jingsong; Cheng, Yi

    2010-01-01

    This paper gives a recursion operator for a 1-constrained CKP hierarchy, and by the recursion operator it proves that the 1-constrained CKP hierarchy can be reduced to the mKdV hierarchy under condition $q=r$.

  1. Kinetic and structural studies reveal a unique binding mode of sulfite to the nickel center in urease

    OpenAIRE

    Mazzei, Luca; Cianci, Michele; Benini, Stefano; Bertini, Leonardo; Musiani, Francesco; Ciurli, Stefano

    2016-01-01

    Urease is the most efficient enzyme known to date, and catalyzes the hydrolysis of urea using two Ni(II) ions in the active site. Urease is a virulence factor in several human pathogens, while causing severe environmental and agronomic problems. Sporosarcina pasteurii urease has been used extensively in the structural characterization of the enzyme. Sodium sulfite has been widely used as a preservative in urease solutions to prevent oxygen-induced oxidation, but its role as an inhibitor has a...

  2. The structure of Aquifex aeolicus ribosomal protein S8 reveals a unique subdomain that contributes to an extremely tight association with 16S rRNA.

    Science.gov (United States)

    Menichelli, Elena; Edgcomb, Stephen P; Recht, Michael I; Williamson, James R

    2012-01-20

    The assembly of ribonucleoprotein complexes occurs under a broad range of conditions, but the principles that promote assembly and allow function at high temperature are poorly understood. The ribosomal protein S8 from Aquifex aeolicus (AS8) is unique in that there is a 41-residue insertion in the consensus S8 sequence. In addition, AS8 exhibits an unusually high affinity for the 16S ribosomal RNA, characterized by a picomolar dissociation constant that is approximately 26,000-fold tighter than the equivalent interaction from Escherichia coli. Deletion analysis demonstrated that binding to the minimal site on helix 21 occurred at the same nanomolar affinity found for other bacterial species. The additional affinity required the presence of a three-helix junction between helices 20, 21, and 22. The crystal structure of AS8 was solved, revealing the helix-loop-helix geometry of the unique AS8 insertion region, while the core of the molecule is conserved with known S8 structures. The AS8 structure was modeled onto the structure of the 30S ribosomal subunit from E. coli, suggesting the possibility that the unique subdomain provides additional backbone and side-chain contacts between the protein and an unpaired base within the three-way junction of helices 20, 21, and 22. Point mutations in the protein insertion subdomain resulted in a significantly reduced RNA binding affinity with respect to wild-type AS8. These results indicate that the AS8-specific subdomain provides additional interactions with the three-way junction that contribute to the extremely tight binding to ribosomal RNA.

  3. Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis.

    Directory of Open Access Journals (Sweden)

    Halina Wójtowicz

    2009-05-01

    Full Text Available Infection, survival, and proliferation of pathogenic bacteria in humans depend on their capacity to impair host responses and acquire nutrients in a hostile environment. Among such nutrients is heme, a co-factor for oxygen storage, electron transport, photosynthesis, and redox biochemistry, which is indispensable for life. Porphyromonas gingivalis is the major human bacterial pathogen responsible for severe periodontitis. It recruits heme through HmuY, which sequesters heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR. Here we report that heme binding does not significantly affect the secondary structure of HmuY. The crystal structure of heme-bound HmuY reveals a new all-beta fold mimicking a right hand. The thumb and fingers pinch heme iron through two apical histidine residues, giving rise to highly symmetric octahedral iron co-ordination. The tetrameric quaternary arrangement of the protein found in the crystal structure is consistent with experiments in solution. It shows that thumbs and fingertips, and, by extension, the bound heme groups, are shielded from competing heme-binding proteins from the host. This may also facilitate heme transport to HmuR for internalization. HmuY, both in its apo- and in its heme-bound forms, is resistant to proteolytic digestion by trypsin and the major secreted proteases of P. gingivalis, gingipains K and R. It is also stable against thermal and chemical denaturation. In conclusion, these studies reveal novel molecular properties of HmuY that are consistent with its role as a putative virulence factor during bacterial infection.

  4. A New Star-shaped Carbazole Derivative with Polyhedral Oligomeric Silsesquioxane Core: Crystal Structure and Unique Photoluminescence Property.

    Science.gov (United States)

    Xu, Zixuan; Yu, Tianzhi; Zhao, Yuling; Zhang, Hui; Zhao, Guoyun; Li, Jianfeng; Chai, Lanqin

    2016-01-01

    A new inorganic–organic hybrid material based on polyhedral oligomeric silsesquioxane (POSS) capped with carbazolyl substituents, octakis[3-(carbazol-9-yl)propyldimethylsiloxy]-silsesquioxane (POSS-8Cz), was successfully synthesized and characterized. The X-ray crystal structure of POSS-8Cz were described. The photophysical properties of POSS-8Cz were investigated by using UV–vis,photoluminescence spectroscopic analysis. The hybrid material exhibits blue emission in the solution and the solid film.The morphology and thermal stablity properties were measured by X-ray diffraction (XRD) and TG-DTA analysis.

  5. Kinetic and structural studies reveal a unique binding mode of sulfite to the nickel center in urease.

    Science.gov (United States)

    Mazzei, Luca; Cianci, Michele; Benini, Stefano; Bertini, Leonardo; Musiani, Francesco; Ciurli, Stefano

    2016-01-01

    Urease is the most efficient enzyme known to date, and catalyzes the hydrolysis of urea using two Ni(II) ions in the active site. Urease is a virulence factor in several human pathogens, while causing severe environmental and agronomic problems. Sporosarcina pasteurii urease has been used extensively in the structural characterization of the enzyme. Sodium sulfite has been widely used as a preservative in urease solutions to prevent oxygen-induced oxidation, but its role as an inhibitor has also been suggested. In the present study, isothermal titration microcalorimetry was used to establish sulfite as a competitive inhibitor for S. pasteurii urease, with an inhibition constant of 0.19mM at pH7. The structure of the urease-sulfite complex, determined at 1.65Å resolution, shows the inhibitor bound to the dinuclear Ni(II) center of urease in a tridentate mode involving bonds between the two Ni(II) ions in the active site and all three oxygen atoms of the inhibitor, supporting the observed competitive inhibition kinetics. This coordination mode of sulfite has never been observed, either in proteins or in small molecule complexes, and could inspire synthetic coordination chemists as well as biochemists to develop urease inhibitors based on this chemical moiety.

  6. Qanat -a unique system of water supply in iran. Specifics of structures and principles of engineering devices

    Directory of Open Access Journals (Sweden)

    Rodionovskaya Inna Serafimovna

    2016-11-01

    Full Text Available A considerable part of the world population is living in a geographical belt of hot and dry climate. The rainfalls there are rare and there is lack of fresh water basins and water sources. That’s why a powerful water supply system was developed here, which has been operating for centuries, and a technology of its construction has been improved to the level of art. The specific nature of hydro-technical water supply system of Iranian settlements is considered in this article. Such specificity is typical for the regions with mountain relief in the conditions of hot-dry climate. Also, the construction characteristics of the system, its structure and building components are given as well as short information about the features of buildings constructions and their technical operation. Functional, urban-architectural and environmental aspects are considered; the influence of the hydraulic system on the population resettlement is specified. The role of these structures is noted in respect of environment greening. Informational and cognitive nature of the given material allows using it in educational process of architects and civil engineers, expanding their professional horizons, as well as in scientific researches aimed at finding the ways of ecologization of modern architectural environment in the condition of urbanization development.

  7. Crystal structure of TNF-α-inducing protein from Helicobacter pylori in active form reveals the intrinsic molecular flexibility for unique DNA-binding.

    Directory of Open Access Journals (Sweden)

    Mingming Gao

    Full Text Available Tipα (TNF-α-inducing protein from Helicobacter pylori is a carcinogenic effector. Studies on this protein revealed that a homodimer linked by a pair of intermolecular disulfide bridges (Cys25-Cys25 and Cys27-Cys27 was absolutely necessary for its biological functions. The activities of Tipα would be abolished when both disulfide bridges were disrupted. The crystal structures of Tipα reported to date, however, were based on inactive, monomeric mutants with their N-terminal, including residues Cys25 and Cys27, truncated. Here we report the crystal structure of H. pylori Tipα protein, TipαN(25, at 2.2Å resolution, in which Cys25 and Cys27 form a pair of inter-chain disulfide bridges linking an active dimer. The disulfide bridges exhibit structural flexibility in the present structure. A series of structure-based mutagenesis, biochemical assays and molecular dynamic simulations on DNA-Tipα interactions reveal that Tipα utilizes the dimeric interface as the DNA-binding site and that residues His60, Arg77 and Arg81 located at the interface are crucial for DNA binding. Tipα could bind to one ssDNA, two ssDNA or one dsDNA in experiments, respectively, in the native or mutant states. The unique DNA-binding activities of Tipα indicate that the intrinsic flexible nature of disulfide bridges could endow certain elasticity to the Tipα dimer for its unique bioactivities. The results shed light on the possible structural mechanism for the functional performances of Tipα.

  8. The crystal structure of Haloferax volcanii proliferating cell nuclear antigen reveals unique surface charge characteristics due to halophilic adaptation

    Directory of Open Access Journals (Sweden)

    Morroll Shaun

    2009-08-01

    Full Text Available Abstract Background The high intracellular salt concentration required to maintain a halophilic lifestyle poses challenges to haloarchaeal proteins that must stay soluble, stable and functional in this extreme environment. Proliferating cell nuclear antigen (PCNA is a fundamental protein involved in maintaining genome integrity, with roles in both DNA replication and repair. To investigate the halophilic adaptation of such a key protein we have crystallised and solved the structure of Haloferax volcanii PCNA (HvPCNA to a resolution of 2.0 Å. Results The overall architecture of HvPCNA is very similar to other known PCNAs, which are highly structurally conserved. Three commonly observed adaptations in halophilic proteins are higher surface acidity, bound ions and increased numbers of intermolecular ion pairs (in oligomeric proteins. HvPCNA possesses the former two adaptations but not the latter, despite functioning as a homotrimer. Strikingly, the positive surface charge considered key to PCNA's role as a sliding clamp is dramatically reduced in the halophilic protein. Instead, bound cations within the solvation shell of HvPCNA may permit sliding along negatively charged DNA by reducing electrostatic repulsion effects. Conclusion The extent to which individual proteins adapt to halophilic conditions varies, presumably due to their diverse characteristics and roles within the cell. The number of ion pairs observed in the HvPCNA monomer-monomer interface was unexpectedly low. This may reflect the fact that the trimer is intrinsically stable over a wide range of salt concentrations and therefore additional modifications for trimer maintenance in high salt conditions are not required. Halophilic proteins frequently bind anions and cations and in HvPCNA cation binding may compensate for the remarkable reduction in positive charge in the pore region, to facilitate functional interactions with DNA. In this way, HvPCNA may harness its environment as

  9. Evidence for predilection of macrophage infiltration patterns in the deeper midline and mesial temporal structures of the brain uniquely in patients with HIV-associated dementia

    Directory of Open Access Journals (Sweden)

    Hsu Kenneth

    2009-12-01

    Full Text Available Abstract Background HIV-1 penetrates the central nervous system, which is vital for HIV-associated dementia (HAD. But the role of cellular infiltration and activation together with HIV in the development of HAD is poorly understood. Methods To study activation and infiltration patterns of macrophages, CD8+ T cells in relation to HIV in diverse CNS areas of patients with and without dementia. 46 brain regions from two rapidly progressing severely demented patients and 53 regions from 4 HIV+ non-dementia patients were analyzed. Macrophage and CD8+ T cell infiltration of the CNS in relation to HIV was assessed using immuno-histochemical analysis with anti-HIV (P24, anti-CD8 and anti-CD68, anti-S-100A8 and granzyme B antibodies (cellular activation. Statistical analysis was performed with SPSS 12.0 with Student's t test and ANOVA. Results Overall, the patterns of infiltration of macrophages and CD8+ T cells were indiscernible between patients with and without dementia, but the co-localization of macrophages and CD8+ T cells along with HIV P24 antigen in the deeper midline and mesial temporal structures of the brain segregated the two groups. This predilection of infected macrophages and CD8+ T cells to the middle part of the brain was unique to both HAD patients, along with unique nature of provirus gag gene sequences derived from macrophages in the midline and mesial temporal structures. Conclusion Strong predilection of infected macrophages and CD8+ T cells was typical of the deeper midline and mesial temporal structures uniquely in HAD patients, which has some influence on neurocognitive impairment during HIV infection.

  10. Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

    Energy Technology Data Exchange (ETDEWEB)

    Han, Seungil; Mistry, Anil; Chang, Jeanne S.; Cunningham, David; Griffor, Matt; Bonnette, Peter C.; Wang, Hong; Chrunyk, Boris A.; Aspnes, Gary E.; Walker, Daniel P.; Brosius, Arthur D.; Buckbinder, Leonard; Pfizer

    2009-05-21

    Proline-rich tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and considered a viable drug target for osteoporosis treatment. The high-resolution structures of the human PYK2 kinase domain with different inhibitor complexes establish the conventional bilobal kinase architecture and show the conformational variability of the DFG loop. The basis for the lack of selectivity for the classical kinase inhibitor, PF-431396, within the FAK family is explained by our structural analyses. Importantly, the novel DFG-out conformation with two diarylurea inhibitors (BIRB796, PF-4618433) reveals a distinct subclass of non-receptor tyrosine kinases identifiable by the gatekeeper Met-502 and the unique hinge loop conformation of Leu-504. This is the first example of a leucine residue in the hinge loop that blocks the ATP binding site in the DFG-out conformation. Our structural, biophysical, and pharmacological studies suggest that the unique features of the DFG motif, including Leu-504 hinge-loop variability, can be exploited for the development of selective protein kinase inhibitors.

  11. Encoding Lexicalized Tree Adjoining Grammars with a Nonmonotonic Inheritance Hierarchy

    CERN Document Server

    Evans, R; Weir, D; Evans, Roger; Gazdar, Gerald; Weir, David

    1995-01-01

    This paper shows how DATR, a widely used formal language for lexical knowledge representation, can be used to define an LTAG lexicon as an inheritance hierarchy with internal lexical rules. A bottom-up featural encoding is used for LTAG trees and this allows lexical rules to be implemented as covariation constraints within feature structures. Such an approach eliminates the considerable redundancy otherwise associated with an LTAG lexicon.

  12. An Integrable Symplectic Map of a Differential-Difference Hierarchy

    Institute of Scientific and Technical Information of China (English)

    DONG Huan-He; YI Fang-Jiao; SU Jie; LU Guo-Zhi

    2012-01-01

    By choosing a discrete matrix spectral problem, a hierarchy of integrable differential-difference equations is derived from the discrete zero curvature equation, and the Hamiltonian structures are built. Through a higher-order Bargmann symmetry constraint, the spatial part and the temporal part of the Lax pairs and adjoint Lax pairs, which we obtained are respectively nonlinearized into a new integrable symplectic map and a finite-dimensional integrable Hamiltonian system in Liouville sense.

  13. Application of Fuzzy QFD to Aircraft Top Hierarchy Design

    Institute of Scientific and Technical Information of China (English)

    XIE Jian-xi; SONG Bi-feng; LIU Dong-xia

    2004-01-01

    In this paper, based on the Quality Function Deployment (QFD) method, the Fuzzy Quality Function Deployment (FQFD) theory and the step-by-step hierarchy structure in aircraft top decision design are studied. The fuzzy model for computing competitive factor in evaluation is presented.The decision of key technologies for improving the performance and affordability of a fixed-wing aircraft is studied using the model, and the result proves the feasibility of this model.

  14. Quantitative Analysis of Major Factors Affecting Black Carbon Transport and Concentrations in the Unique Atmospheric Structures of Urban Environment

    Science.gov (United States)

    Liang, Marissa Shuang

    Black carbon (BC) from vehicular emission in transportation is a principal component of particulate matters ≤ 2.5 mum (PM2.5). PM2.5 and other diesel emission pollutants (e.g., NOx) are regulated by the Clean Air Act (CAA) according to the National Ambient Air Quality standards (NAAQS). This doctoral dissertation details a study on transport behaviors of black carbon and PM2.5 from transportation routes, their relations with the atmospheric structure of an urban formation, and their relations with the use of biodiesel fuels. The results have implications to near-road risk assessment and to the development of sustainable transportation solutions in urban centers. The first part of study quantified near-roadside black carbon transport as a function of particulate matter (PM) size and composition, as well as microclimatic variables (temperature and wind fields) at the interstate highway I-75 in northern Cincinnati, Ohio. Among variables examined, wind speed and direction significantly affect the roadside transport of black carbon and hence its effective emission factor. Observed non-Gaussian dispersion occurred during low wind and for wind directions at acute angles or upwind to the receptors, mostly occurring in the morning hours. Meandering of air pollutant mass under thermal inversion is likely the driving force. In contrary, Gaussian distribution predominated in daytime of strong downwinds. The roles of urban atmospheric structure, wind fields, and the urban heat island (UHI) effects were further examined on pollutant dispersion and transport. Spatiotemporal variations of traffic flow, atmospheric structure, ambient temperature and PM2.5 concentration data from 14 EPA-certified NAAQS monitoring stations, were analyzed in relation to land-use in the Cincinnati metropolitan area. The results show a decade-long UHI effects with higher interior temperature than that in exurban, and a prominent nocturnal thermal inversion frequent in urban boundary layer. The

  15. Systematic study of aggregation structure and thermal behavior of a series of unique H-shape alkane molecules.

    Science.gov (United States)

    Yamamoto, Hiroko; Tashiro, Kohji; Nemoto, Norio; Motoyama, Yukihiro; Takahashi, Yoshiaki

    2011-08-11

    The H-shape alkanes of various arm lengths have been synthesized successfully through the Grignard reaction. The detailed investigation of these novel compounds may allow us to widen the topological chemistry field furthermore. The molecular form and molecular packing structure in the crystal lattice have been revealed successfully on the basis of X-ray structure analysis as well as the analysis of Raman longitudinal acoustic modes (LAM) sensitive to the alkyl zigzag chain segments. The molecular conformation in the crystal lattice is deformed markedly from the originally imagined H-shape. In the cases of C3HOH to C6HOH, for example, the molecules are packed in a complicated manner and the OH···O hydrogen bonds govern the whole intermolecular interactions mainly. Since the alkyl segmental length is not very long, the conformational change is not very drastic, i.e., the small configurational entropy. Synergic effect of the hydrogen bonds and the small configurational entropy gives the higher melting point as known from the thermal data. On the other hand, in the cases of C10HOH and C12HOH, one of the long alkyl chain arms is found to be bent by 90° so that all of the alky chain segments of planar-zigzag conformation can be packed as closely as possible, and the intermolecular OH···O hydrogen bonds are also formed effectively without any mistake. As a result, the contribution of nonbonded intra- and intermolecular van der Waals interactions between the trans-zigzag alkyl chain segments become major, and the coupling of this enthalpy effect with the larger configurational entropy effect of the molecular shape results in the decrement of the melting point which approaches gradually that of longer n-alkane compound. In this way a sensitive balance between the nonbonded van der Waals interactions, the OH···O hydrogen bonds, as well as the configurational entropy effect gives the characteristic thermal behavior of the H-shape compounds. The thus

  16. Formal language theory: refining the Chomsky hierarchy.

    Science.gov (United States)

    Jäger, Gerhard; Rogers, James

    2012-07-19

    The first part of this article gives a brief overview of the four levels of the Chomsky hierarchy, with a special emphasis on context-free and regular languages. It then recapitulates the arguments why neither regular nor context-free grammar is sufficiently expressive to capture all phenomena in the natural language syntax. In the second part, two refinements of the Chomsky hierarchy are reviewed, which are both relevant to the extant research in cognitive science: the mildly context-sensitive languages (which are located between context-free and context-sensitive languages), and the sub-regular hierarchy (which distinguishes several levels of complexity within the class of regular languages).

  17. UC hierarchy and monodromy preserving deformation

    CERN Document Server

    Tsuda, Teruhisa

    2010-01-01

    The UC hierarchy is an extension of the KP hierarchy, which possesses not only an infinite set of positive time evolutions but also that of negative ones. Through a similarity reduction we derive from the UC hierarchy a class of the Schlesinger systems including the Garnier system and the sixth Painleve equation, which describes the monodromy preserving deformations of Fuchsian linear differential equations with certain spectral types. We also present a unified formulation of the above Schlesinger systems as a canonical Hamiltonian system whose Hamiltonian functions are polynomials in the canonical variables.

  18. Reduced graphene oxide composites with water soluble copolymers having tailored lower critical solution temperatures and unique tube-like structure

    Science.gov (United States)

    Namvari, Mina; Biswas, Chandra S.; Galluzzi, Massimiliano; Wang, Qiao; Du, Bing; Stadler, Florian J.

    2017-01-01

    Nanohybrids of graphene with water soluble polymer were synthesized using ‘grafting from’ method. GO, prepared by modified Hummers’ method, was first reacted with sodium azide. Alkyne-terminated RAFT-CTA was synthesized by reaction of propargyl alcohol and S-1-dodecyl-S’-(α,α‘-dimethyl-α”-acetic acid) trithiocarbonate. RAFT-CTA was grafted onto the GO sheets by facile click-reaction and subsequently, N-isopropylacrylamide (NIPAM) and N-ethyleacrylamide (NEAM) were polymerized on graphene sheets via RAFT polymerization method. The respective copolymers with different ratios were also prepared. The nanohybrids were characterized by FTIR, XRD, TGA, Raman, SEM, and AFM. Both SEM and AFM clearly showed rod-like structures for rGO-PNEAM. XRD showed a small peak at 2θ = 19.21°, corresponding to d-spacing ≈ 4.6 Å. In addition, the nanohybrids showed a very broad temperature range for the LCST in water between ca. 30 and 70 °C. PMID:28291225

  19. 3-cm Fine Structure Masers: A Unique Signature of Supermassive Black Hole Formation via Direct Collapse in the Early Universe

    CERN Document Server

    Dijkstra, Mark; Loeb, Abraham

    2016-01-01

    The direct collapse black hole (DCBH) scenario describes the isothermal collapse of a pristine gas cloud directly into a massive, M_BH=10^4-10^6 M_sun black hole. In this paper we show that large HI column densities of primordial gas at T~10^4 K with low molecular abundance - which represent key aspects of the DCBH scenario - provide optimal conditions for pumping of the 2p-level of atomic hydrogen by trapped Lyman alpha (Lya) photons. This Lya pumping mechanism gives rise to inverted level population of the 2s_1/2-2p_3/2 transition, and therefore to stimulated fine structure emission at 3.04 cm (rest-frame). We show that simplified models of the DCBH scenario amplify the CMB by up to a factor of 10^5, above which the maser saturates. Hyperfine splitting of the 3-cm transition gives rise to a characteristic broad (FWHM ~ tens of MHz in the observers frame) asymmetric line profile. This signal subtends an angular scale of ~ 1-10 mas, which translates to a flux of ~ 0.3-3 microJy, which is detectable with ultra...

  20. Reduced graphene oxide composites with water soluble copolymers having tailored lower critical solution temperatures and unique tube-like structure

    Science.gov (United States)

    Namvari, Mina; Biswas, Chandra S.; Galluzzi, Massimiliano; Wang, Qiao; Du, Bing; Stadler, Florian J.

    2017-03-01

    Nanohybrids of graphene with water soluble polymer were synthesized using ‘grafting from’ method. GO, prepared by modified Hummers’ method, was first reacted with sodium azide. Alkyne-terminated RAFT-CTA was synthesized by reaction of propargyl alcohol and S-1-dodecyl-S’-(α,α‘-dimethyl-α”-acetic acid) trithiocarbonate. RAFT-CTA was grafted onto the GO sheets by facile click-reaction and subsequently, N-isopropylacrylamide (NIPAM) and N-ethyleacrylamide (NEAM) were polymerized on graphene sheets via RAFT polymerization method. The respective copolymers with different ratios were also prepared. The nanohybrids were characterized by FTIR, XRD, TGA, Raman, SEM, and AFM. Both SEM and AFM clearly showed rod-like structures for rGO-PNEAM. XRD showed a small peak at 2θ = 19.21°, corresponding to d-spacing ≈ 4.6 Å. In addition, the nanohybrids showed a very broad temperature range for the LCST in water between ca. 30 and 70 °C.

  1. Topological Strings and Integrable Hierarchies

    CERN Document Server

    Aganagic, M; Klemm, A D; Marino, M; Vafa, C; Aganagic, Mina; Dijkgraaf, Robbert; Klemm, Albrecht; Marino, Marcos; Vafa, Cumrun

    2006-01-01

    We consider the topological B-model on local Calabi-Yau geometries. We show how one can solve for the amplitudes by using W-algebra symmetries which encodes the symmetries of holomorphic diffeomorphisms of the Calabi-Yau. In the highly effective fermionic/brane formulation this leads to a free fermion description of the amplitudes. Furthermore we argue that topological strings on Calabi-Yau geometries provide a unifying picture connecting non-critical (super)strings, integrable hierarchies, and various matrix models. In particular we show how the ordinary matrix model, the double scaling limit of matrix models, and Kontsevich-like matrix model are all related and arise from studying branes in specific local Calabi-Yau three-folds. We also show how A-model topological string on P^1 and local toric threefolds (and in particular the topological vertex) can be realized and solved as B-model topological string amplitudes on a Calabi-Yau manifold.

  2. Topological Strings and Integrable Hierarchies

    Science.gov (United States)

    Aganagic, Mina; Dijkgraaf, Robbert; Klemm, Albrecht; Mariño, Marcos; Vafa, Cumrun

    2006-01-01

    We consider the topological B-model on local Calabi-Yau geometries. We show how one can solve for the amplitudes by using -algebra symmetries which encode the symmetries of holomorphic diffeomorphisms of the Calabi-Yau. In the highly effective fermionic/brane formulation this leads to a free fermion description of the amplitudes. Furthermore we argue that topological strings on Calabi-Yau geometries provide a unifying picture connecting non-critical (super)strings, integrable hierarchies, and various matrix models. In particular we show how the ordinary matrix model, the double scaling limit of matrix models, and Kontsevich-like matrix model are all related and arise from studying branes in specific local Calabi-Yau three-folds. We also show how an A-model topological string on P1 and local toric threefolds (and in particular the topological vertex) can be realized and solved as B-model topological string amplitudes on a Calabi-Yau manifold.

  3. Quark masses and their hierarchies

    Science.gov (United States)

    Ida, M.

    1987-12-01

    Electroweak symmetry breaking is attributed to dynamical generation of quark masses. Quarks q (and leptons l) are assumed to be produced by hypercolor confinement of preons at an intermediate scale Λ hc. Hierarchies observed in the q mass spectra can be explained by a BCS mechanism if the color interaction is enough asymptotically free and if residual ones emerging by the confinement are medium strong. The former assumption claims that N≦4, where N is the family number of q and l. Dynamical equations to determine q masses and mixings are given, but they require knowledge on the physics at Λ hc. A phenomenological approach is also made on the basis of an SU(7)× SU(7) chiral preon model with N=4. The mass ratio m t/ mb is related to ( m c/ m s)ηB with η B≃1.1 and m t'/ mb' to ( m u/ m d)ηA with η A≃1.4. In this scheme the fourth down quark is the heaviest (˜ 110 GeV) and contributes dominantly to F 2, where F is the Fermi scale.

  4. Hierarchy of modular graph identities

    Energy Technology Data Exchange (ETDEWEB)

    D’Hoker, Eric; Kaidi, Justin [Mani L. Bhaumik Institute for Theoretical Physics, Department of Physics and Astronomy,University of California,Los Angeles, CA 90095 (United States)

    2016-11-09

    The low energy expansion of Type II superstring amplitudes at genus one is organized in terms of modular graph functions associated with Feynman graphs of a conformal scalar field on the torus. In earlier work, surprising identities between two-loop graphs at all weights, and between higher-loop graphs of weights four and five were constructed. In the present paper, these results are generalized in two complementary directions. First, all identities at weight six and all dihedral identities at weight seven are obtained and proven. Whenever the Laurent polynomial at the cusp is available, the form of these identities confirms the pattern by which the vanishing of the Laurent polynomial governs the full modular identity. Second, the family of modular graph functions is extended to include all graphs with derivative couplings and worldsheet fermions. These extended families of modular graph functions are shown to obey a hierarchy of inhomogeneous Laplace eigenvalue equations. The eigenvalues are calculated analytically for the simplest infinite sub-families and obtained by Maple for successively more complicated sub-families. The spectrum is shown to consist solely of eigenvalues s(s−1) for positive integers s bounded by the weight, with multiplicities which exhibit rich representation-theoretic patterns.

  5. Modeling Leadership Hierarchy in Multilevel Animal Societies

    CERN Document Server

    Ozogány, Katalin

    2014-01-01

    A typical feature of many natural and social networks is the presence of communities giving rise to multiple levels of organization. We investigate the decision-making process of a group combining self organization and social dynamics, and reproduce the simultaneous emergence of a hierarchical and modular leadership network. All individuals in the model try, with varying degrees of ability, to find a direction of movement, with the result that leader-follower relationships evolve between them, since they tend to follow the more successful ones. The harem-forming ambitions of male individuals inspired by an observed Przewalski horse herd (Hortob\\'agy, Hungary) leads to modular structure. In this approach we find that the harem-leader to harem-member ratio observed in horses corresponds to an optimal network regarding common success, and that modularly structured hierarchy is more benefical than a non-modular one, in the sense that common success is higher, and the underlying network is more hierarchical. We al...

  6. Mirror quintic vacua: hierarchies and inflation

    CERN Document Server

    Bizet, Nana Cabo; Zavala, Ivonne

    2016-01-01

    We study the moduli space of type IIB string theory flux compactifications on the mirror of the CY quintic 3-fold in P4. We focus on the dynamics of the four dimensional moduli space, defined by the axio-dilaton {\\tau} and the complex structure modulus z. The z-plane has critical points, the conifold, the orbifold and the large complex structure with non trivial monodromies. We find the solutions to the Picard-Fuchs equations obeyed by the periods of the CY in the full z-plane as a series expansion in z around the critical points to arbitrary order. This allows us to discard fake vacua, which appear as a result of keeping only the leading order term in the series expansions. Due to monodromies vacua are located at a given sheet in the z-plane. A dS vacuum appears for a set of fluxes. We revisit vacua with hierarchies among the 4D and 6D physical scales close to the conifold point and compare them with those found at leading order in [1, 2]. We explore slow-roll inflationary directions of the scalar potential ...

  7. 3-cm Fine Structure Masers: A Unique Signature of Supermassive Black Hole Formation via Direct Collapse in the Early Universe

    Science.gov (United States)

    Dijkstra, Mark; Sethi, Shiv; Loeb, Abraham

    2016-03-01

    The direct collapse black hole (DCBH) scenario describes the isothermal collapse of a pristine gas cloud directly into a massive, {M}{BH} = 104-106{M}⊙ black hole. In this paper we show that large H i column densities of primordial gas at T˜ {10}4 K with low molecular abundance—which represent key aspects of the DCBH scenario—provide optimal conditions for the pumping of the 2p-level of atomic hydrogen by trapped Lyα photons. This Lyα pumping mechanism gives rise to an inverted level population of the 2{s}1/2-2{p}3/2 transition, and therefore also gives rise to stimulated fine structure emission at λ =3.04 {cm} (rest-frame). We show that simplified models of the DCBH scenario amplify the CMB by up to a factor of ˜ {10}5, above which the maser saturates. Hyperfine splitting of the 3 cm transition gives rise to a characteristic broad (FWHM ˜ tens of MHz in the observers frame) asymmetric line profile. This signal subtends an angular scale of ˜1-10 mas, which translates to a flux of ˜0.3-3 μJy, which is detectable with ultra-deep surveys being planned with SKA1-MID. While challenging, as the signal is visible for a fraction of the collapse time of the cloud, the matching required physical conditions imply that a detection of the redshifted 3-cm emission line could provide direct evidence for the DCBH scenario.

  8. Structural and functional characterization of the Geobacillus copper nitrite reductase: involvement of the unique N-terminal region in the interprotein electron transfer with its redox partner.

    Science.gov (United States)

    Fukuda, Yohta; Koteishi, Hiroyasu; Yoneda, Ryohei; Tamada, Taro; Takami, Hideto; Inoue, Tsuyoshi; Nojiri, Masaki

    2014-03-01

    The crystal structures of copper-containing nitrite reductase (CuNiR) from the thermophilic Gram-positive bacterium Geobacillus kaustophilus HTA426 and the amino (N)-terminal 68 residue-deleted mutant were determined at resolutions of 1.3Å and 1.8Å, respectively. Both structures show a striking resemblance with the overall structure of the well-known CuNiRs composed of two Greek key β-barrel domains; however, a remarkable structural difference was found in the N-terminal region. The unique region has one β-strand and one α-helix extended to the northern surface of the type-1 copper site. The superposition of the Geobacillus CuNiR model on the electron-transfer complex structure of CuNiR with the redox partner cytochrome c551 in other denitrifier system led us to infer that this region contributes to the transient binding with the partner protein during the interprotein electron transfer reaction in the Geobacillus system. Furthermore, electron-transfer kinetics experiments using N-terminal residue-deleted mutant and the redox partner, Geobacillus cytochrome c551, were carried out. These structural and kinetics studies demonstrate that the region is directly involved in the specific partner recognition.

  9. Random walk hierarchy measure: What is more hierarchical, a chain, a tree or a star?

    CERN Document Server

    Czégel, Dániel

    2015-01-01

    Signs of hierarchy are prevalent in a wide range of systems in nature and society. One of the key problems is quantifying the importance of hierarchical organisation in the structure of the network representing the interactions or connections between the fundamental units of the studied system. Although a number of notable methods are already available, their vast majority is treating all directed acyclic graphs as already maximally hierarchical. Here we propose a hierarchy measure based on random walks on the network. The novelty of our approach is that directed trees corresponding to multi level pyramidal structures obtain higher hierarchy scores compared to directed chains and directed stars. Furthermore, in the thermodynamic limit the hierarchy measure of regular trees is converging to a well defined limit depending only on the branching number. When applied to real networks, our method is computationally very effective, as the result can be evaluated with arbitrary precision by subsequent multiplications...

  10. A Game-Theoretical Winner and Loser Model of Dominance Hierarchy Formation.

    Science.gov (United States)

    Kura, Klodeta; Broom, Mark; Kandler, Anne

    2016-06-01

    Many animals spend large parts of their lives in groups. Within such groups, they need to find efficient ways of dividing available resources between them. This is often achieved by means of a dominance hierarchy, which in its most extreme linear form allocates a strict priority order to the individuals. Once a hierarchy is formed, it is often stable over long periods, but the formation of hierarchies among individuals with little or no knowledge of each other can involve aggressive contests. The outcome of such contests can have significant effects on later contests, with previous winners more likely to win (winner effects) and previous losers more likely to lose (loser effects). This scenario has been modelled by a number of authors, in particular by Dugatkin. In his model, individuals engage in aggressive contests if the assessment of their fighting ability relative to their opponent is above a threshold [Formula: see text]. Here we present a model where each individual can choose its own value [Formula: see text]. This enables us to address questions such as how aggressive should individuals be in order to take up one of the first places in the hierarchy? We find that a unique strategy evolves, as opposed to a mixture of strategies. Thus, in any scenario there exists a unique best level of aggression, and individuals should not switch between strategies. We find that for optimal strategy choice, the hierarchy forms quickly, after which there are no mutually aggressive contests.

  11. On (not) overcoming our history of hierarchy: Complexities of university/school collaboration

    Science.gov (United States)

    Carlone, Heidi B.; Webb, Sandra M.

    2006-05-01

    Science educators have recently begun to enact and study new, collaborative forms of professional development. Yet, few recognize that doing so requires contesting historical meanings of university-school collaboration and professional development, both of which may operate to sustain a hierarchy model of collaboration. The hierarchy model maintains the flow of information and knowledge from universities to teachers to students. In science education, the hierarchy model may be strengthened by science's own history of hierarchy. This study describes the authors' attempt to contest the hierarchy model by facilitating a collaborative planning project with elementary teachers. Critical discourse analysis is used as the primary theoretical and methodological tool to (1) explain how the hierarchy model was shaped by and shaped the group's actions, interactions, and identities; (2) explain the complexities of collaboration by moving beyond deficit-based explanations (e.g., blaming individuals or organizational structures); (3) offer theoretical and methodological approaches for understanding better the nature of collaboration and practical solutions for those attempting to challenge the history of hierarchy. In focusing on how meaning is made in interaction, the authors demonstrate how language and interaction are inextricably bound with history and culture.

  12. Comparing the Hierarchy of Keywords in On-Line News Portals

    Science.gov (United States)

    Tibély, Gergely; Sousa-Rodrigues, David; Pollner, Péter; Palla, Gergely

    2016-01-01

    Hierarchical organization is prevalent in networks representing a wide range of systems in nature and society. An important example is given by the tag hierarchies extracted from large on-line data repositories such as scientific publication archives, file sharing portals, blogs, on-line news portals, etc. The tagging of the stored objects with informative keywords in such repositories has become very common, and in most cases the tags on a given item are free words chosen by the authors independently. Therefore, the relations among keywords appearing in an on-line data repository are unknown in general. However, in most cases the topics and concepts described by these keywords are forming a latent hierarchy, with the more general topics and categories at the top, and more specialized ones at the bottom. There are several algorithms available for deducing this hierarchy from the statistical features of the keywords. In the present work we apply a recent, co-occurrence-based tag hierarchy extraction method to sets of keywords obtained from four different on-line news portals. The resulting hierarchies show substantial differences not just in the topics rendered as important (being at the top of the hierarchy) or of less interest (categorized low in the hierarchy), but also in the underlying network structure. This reveals discrepancies between the plausible keyword association frameworks in the studied news portals. PMID:27802319

  13. Comparing the Hierarchy of Keywords in On-Line News Portals.

    Science.gov (United States)

    Tibély, Gergely; Sousa-Rodrigues, David; Pollner, Péter; Palla, Gergely

    2016-01-01

    Hierarchical organization is prevalent in networks representing a wide range of systems in nature and society. An important example is given by the tag hierarchies extracted from large on-line data repositories such as scientific publication archives, file sharing portals, blogs, on-line news portals, etc. The tagging of the stored objects with informative keywords in such repositories has become very common, and in most cases the tags on a given item are free words chosen by the authors independently. Therefore, the relations among keywords appearing in an on-line data repository are unknown in general. However, in most cases the topics and concepts described by these keywords are forming a latent hierarchy, with the more general topics and categories at the top, and more specialized ones at the bottom. There are several algorithms available for deducing this hierarchy from the statistical features of the keywords. In the present work we apply a recent, co-occurrence-based tag hierarchy extraction method to sets of keywords obtained from four different on-line news portals. The resulting hierarchies show substantial differences not just in the topics rendered as important (being at the top of the hierarchy) or of less interest (categorized low in the hierarchy), but also in the underlying network structure. This reveals discrepancies between the plausible keyword association frameworks in the studied news portals.

  14. An Analytic Hierarchy Process (AHP) Approach to Port Selection Decisions – Empirical Evidence from Nigerian Ports

    OpenAIRE

    Chinonye Ugboma; Ogochukwu Ugboma; Innocent C Ogwude

    2006-01-01

    This study presents the findings of a survey to determine the service characteristics that shippers consider important when selecting a port and the way these characteristics are prioritised according to their importance. Seven criteria for the port selection decision and four ports were identified, and the decision problem was structured into a three-level hierarchy using the Analytic Hierarchy Process. The findings suggest that shippers place high emphasis on efficiency, frequency of ship v...

  15. An integrable Poisson map generated from the eigenvalue problem of the Lotka-Volterra hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Wu Yongtang [Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong (China); Wang Hongye [Department of Mathematics, Zhengzhou University, Henan (China); Du Dianlou [Department of Mathematics, Zhengzhou University, Henan (China)]. E-mail: ddl@zzu.edu.cn

    2002-05-03

    A 3x3 discrete eigenvalue problem associated with the Lotka-Volterra hierarchy is studied and the corresponding nonlinearized one, an integrable Poisson map with a Lie-Poisson structure, is also presented. Moreover, a 2x2 nonlinearized eigenvalue problem, which also begets the Lotka-Volterra hierarchy, is proved to be a reduction of the Poisson map on the leaves of the symplectic foliation. (author)

  16. Integrable Couplings of the Coupled Burgers Hierarchy

    Institute of Scientific and Technical Information of China (English)

    XIATie-Cheng; CHENXiao-Hong; CHENDeng-Yuan; ZHANGYu-Feng

    2004-01-01

    In this letter, a new loop algebra G is constructed, from which a new isospectral problem is established. It follows that integrable couplings of the well-known coupled Burgers hierarchy are obtained.

  17. 我国大都市区轨道交通网络结构演进:由等级到协同%Evolution of Metropolitan Rail Transit Network Structure in China:From Hierarchy to Synergy

    Institute of Scientific and Technical Information of China (English)

    陈小君

    2015-01-01

    大都市区轨道交通网络在新型城镇化、工业化、运输化快速推进过程中的基础作用毋庸置疑。而针对目前我国大都市区轨道交通网络结构演进过程中存在服务半径与大都市区交通需求分布不一致的问题,应重视从协同发展视角而非等级视角来明晰轨道交通网络结构中线路与节点的转变内容及特征,重新确立市郊铁路及重要节点在我国大都市区轨道交通网络结构演进过程中的地位与作用,补充完善我国大都市区轨道交通网络结构演变的指标内容,以期推进我国大都市区轨道交通网络演进过程的顺利进行。%Metropolitan rail transit network plays a foundational role in promoting the fast development of new-type urbanization ,industrialization and transportation .In response to the inconsistency between the service radius and the distribution of metropolitan transportation needs the evolution of metropolitan rail transit network in China ,this paper argues that the perspective of synergy rather than that of hierarchy shall be taken to fulfill three purposes ,namely ,to clarify the transformation and features of the lines and the nodes in rail transit network ,to re-establish the status and functions of suburban railway and important nodes and to complete the index system of the structural evolution of metropolitan rail transit network .It is hoped thus the evolution of metropolitan rail transit network in China can be promoted .

  18. Theory of uniqueness of Indian Caste System

    OpenAIRE

    Kumar, Ashwin

    2006-01-01

    Classical studies on pre-modern Indian social structure have suggested apparent differences between the Indian caste system and social stratification as one can discern in other parts of the world. However, one needs to question such dogmatic assertions that such vast differences really existed. An endeavor is made in this research paper to reflect on the nature of caste hierarchy in pre-modern India. The caste system forms the significant basis of pre-modern Indian social structure. Early wr...

  19. Cities, Wages, and the Urban Hierarchy

    OpenAIRE

    Juan D. Soto; Dusan Paredes

    2014-01-01

    We present evidence regarding the unequal spatial distribution of population in the north and south of Chile which implies that even when geographical distances to the main urban center are similar, the distances in a context of urban hierarchy are completely di?erent. Given this economic geography, we postulate that Central Place Theory provides a better understanding for the study of city size wage gap in Chile. In order to test our hypothesis, we construct ?ve tiers of urban hierarchy usin...

  20. The analytic hierarchy process in decisionmaking for caprine health programmes.

    Science.gov (United States)

    Maino, M; Pérez, P; Oviedo, P; Sotomayor, G; Abalos, P

    2012-12-01

    The purpose of this study was to apply the analytic hierarchy process (AHP) to assist decision-making when planning animal health programmes, by assigning priorities to issues of concern to producers in Chile's main goat production region. This process allows a multi-criteria approach to problems, by analysing and ranking them in a hierarchical structure. Industry experts have highlighted the following animal health and disease control criteria: acceptance by breeders of disease control measures; impact of specific diseases on regional animal trade; the cost and efficacy of control measures; a decrease in flock production; and the impact of caprine diseases on human public health. Using these criteria in the AHP, the study found that the most important impacts were on human public health and on the animal trade. The disease priorities were tuberculosis, brucellosis and echinococcosis/hydatidosis, due mainlyto their zoonotic impact. The analytic hierarchy process proved useful when several criteria were involved in public health issues.

  1. Existence of Hierarchies and Human's Pursuit of Top Hierarchy Lead to Power Law

    CERN Document Server

    Yu, Shuiyuan; Liu, Haitao

    2016-01-01

    The power law is ubiquitous in natural and social phenomena, and is considered as a universal relationship between the frequency and its rank for diverse social systems. However, a general model is still lacking to interpret why these seemingly unrelated systems share great similarity. Through a detailed analysis of natural language texts and simulation experiments based on the proposed 'Hierarchical Selection Model', we found that the existence of hierarchies and human's pursuit of top hierarchy lead to the power law. Further, the power law is a statistical and emergent performance of hierarchies, and it is the universality of hierarchies that contributes to the ubiquity of the power law.

  2. Evaluating, Comparing, and Interpreting Protein Domain Hierarchies

    Science.gov (United States)

    2014-01-01

    Abstract Arranging protein domain sequences hierarchically into evolutionarily divergent subgroups is important for investigating evolutionary history, for speeding up web-based similarity searches, for identifying sequence determinants of protein function, and for genome annotation. However, whether or not a particular hierarchy is optimal is often unclear, and independently constructed hierarchies for the same domain can often differ significantly. This article describes methods for statistically evaluating specific aspects of a hierarchy, for probing the criteria underlying its construction and for direct comparisons between hierarchies. Information theoretical notions are used to quantify the contributions of specific hierarchical features to the underlying statistical model. Such features include subhierarchies, sequence subgroups, individual sequences, and subgroup-associated signature patterns. Underlying properties are graphically displayed in plots of each specific feature's contributions, in heat maps of pattern residue conservation, in “contrast alignments,” and through cross-mapping of subgroups between hierarchies. Together, these approaches provide a deeper understanding of protein domain functional divergence, reveal uncertainties caused by inconsistent patterns of sequence conservation, and help resolve conflicts between competing hierarchies. PMID:24559108

  3. Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence.

    Science.gov (United States)

    Harris, Golda G; Lombardi, Patrick M; Pemberton, Travis A; Matsui, Tsutomu; Weiss, Thomas M; Cole, Kathryn E; Köksal, Mustafa; Murphy, Frank V; Vedula, L Sangeetha; Chou, Wayne K W; Cane, David E; Christianson, David W

    2015-12-01

    Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two distinct active sites are required for catalysis: the N-terminal domain catalyzes the ionization and cyclization of farnesyl diphosphate to form germacradienol and inorganic pyrophosphate (PPi), and the C-terminal domain catalyzes the protonation, cyclization, and fragmentation of germacradienol to form geosmin and acetone through a retro-Prins reaction. A unique αα domain architecture is predicted for ScGS based on amino acid sequence: each domain contains the metal-binding motifs typical of a class I terpenoid cyclase, and each domain requires Mg(2+) for catalysis. Here, we report the X-ray crystal structure of the unliganded N-terminal domain of ScGS and the structure of its complex with three Mg(2+) ions and alendronate. These structures highlight conformational changes required for active site closure and catalysis. Although neither full-length ScGS nor constructs of the C-terminal domain could be crystallized, homology models of the C-terminal domain were constructed on the basis of ∼36% sequence identity with the N-terminal domain. Small-angle X-ray scattering experiments yield low-resolution molecular envelopes into which the N-terminal domain crystal structure and the C-terminal domain homology model were fit, suggesting possible αα domain architectures as frameworks for bifunctional catalysis.

  4. Rapidly Mixing Gibbs Sampling for a Class of Factor Graphs Using Hierarchy Width.

    Science.gov (United States)

    De Sa, Christopher; Zhang, Ce; Olukotun, Kunle; Ré, Christopher

    2015-12-01

    Gibbs sampling on factor graphs is a widely used inference technique, which often produces good empirical results. Theoretical guarantees for its performance are weak: even for tree structured graphs, the mixing time of Gibbs may be exponential in the number of variables. To help understand the behavior of Gibbs sampling, we introduce a new (hyper)graph property, called hierarchy width. We show that under suitable conditions on the weights, bounded hierarchy width ensures polynomial mixing time. Our study of hierarchy width is in part motivated by a class of factor graph templates, hierarchical templates, which have bounded hierarchy width-regardless of the data used to instantiate them. We demonstrate a rich application from natural language processing in which Gibbs sampling provably mixes rapidly and achieves accuracy that exceeds human volunteers.

  5. Enabling cell-cell communication via nanopore formation: structure, function and localization of the unique cell wall amidase AmiC2 of Nostoc punctiforme.

    Science.gov (United States)

    Büttner, Felix M; Faulhaber, Katharina; Forchhammer, Karl; Maldener, Iris; Stehle, Thilo

    2016-04-01

    To orchestrate a complex life style in changing environments, the filamentous cyanobacterium Nostoc punctiforme facilitates communication between neighboring cells through septal junction complexes. This is achieved by nanopores that perforate the peptidoglycan (PGN) layer and traverse the cell septa. The N-acetylmuramoyl-l-alanine amidase AmiC2 (Npun_F1846; EC 3.5.1.28) in N. punctiforme generates arrays of such nanopores in the septal PGN, in contrast to homologous amidases that mediate daughter cell separation after cell division in unicellular bacteria. Nanopore formation is therefore a novel property of AmiC homologs. Immunofluorescence shows that native AmiC2 localizes to the maturing septum. The high-resolution crystal structure (1.12 Å) of its catalytic domain (AmiC2-cat) differs significantly from known structures of cell splitting and PGN recycling amidases. A wide and shallow binding cavity allows easy access of the substrate to the active site, which harbors an essential zinc ion. AmiC2-cat exhibits strong hydrolytic activity in vitro. A single point mutation of a conserved glutamate near the zinc ion results in total loss of activity, whereas zinc removal leads to instability of AmiC2-cat. An inhibitory α-helix, as found in the Escherichia coli AmiC(E. coli) structure, is absent. Taken together, our data provide insight into the cell-biological, biochemical and structural properties of an unusual cell wall lytic enzyme that generates nanopores for cell-cell communication in multicellular cyanobacteria. The novel structural features of the catalytic domain and the unique biological function of AmiC2 hint at mechanisms of action and regulation that are distinct from other amidases. The AmiC2-cat structure has been deposited in the Protein Data Bank under accession number 5EMI. © 2016 Federation of European Biochemical Societies.

  6. Unique Physically Anchored Cryptographic Theoretical Calculation of the Fine-Structure Constant {\\alpha} Matching both the g/2 and Interferometric High-Precision Measurements

    CERN Document Server

    Rhodes, Charles Kirkham

    2010-01-01

    The fine-structure constant {\\alpha}, the dimensionless number that represents the strength of electromagnetic coupling in the limit of sufficiently low energy interactions, is the crucial fundamental physical parameter that governs a nearly limitless range of phenomena involving the interaction of radiation with materials. Ideally, the apparatus of physical theory should be competent to provide a calculational procedure that yields a quantitatively correct value for {\\alpha} and the physical basis for its computation. This study presents the first demonstration of an observationally anchored theoretical procedure that predicts a unique value for {\\alpha} that stands in full agreement with the best (~370 ppt) high-precision experimental determinations. In a directly connected cryptographic computation, the method that gives these results also yields the magnitude of the cosmological constant {\\Omega}{\\Lambda} in conformance with the observational data and the condition of perfect flatness ({\\Omega}{\\Lambda} +...

  7. Developing a hierarchy of needs for Type 1 diabetes.

    Science.gov (United States)

    Beran, D

    2014-01-01

    The aim of this study was to use the concept of Maslow's hierarchy of needs and apply this to Type 1 diabetes. Qualitative methods were employed using semi-structured interviews with 101 people from 13 countries. Grounded theory was used for data collection and analysis, with thematic analysis employed to identify the interviewees' needs. Sixteen needs were identified and links between these were mapped. Aligning these with Maslow's hierarchy allowed for a hierarchy to be developed for Type 1 diabetes with 'Policies', 'Organization of health system', 'Insulin', 'Delivery of insulin', 'Control', 'Healthcare workers' and 'Information and education' at the base, as they were needed for survival. Next came 'Community, family and peers' and changing roles for 'Healthcare workers' in their approach to care and delivering 'Information and education'. This enabled people to learn how to use 'Insulin', 'Delivery of insulin' and 'Control' flexibly. People's 'Experience' and 'Personality' then helped them 'Adapt' and 'Be open' about their diabetes, allowing for 'Acceptance' and viewing 'Diabetes as something positive'. Despite limitations, this work highlights that some needs are required for survival and others for well-being. Some are tangible as they can be directly provided, whereas others are intangible and cannot be provided directly by the health system. These results might be used for policy and practice in identifying needs that are met within a health system or what needs are lacking for the individual to then implement targeted interventions. © 2013 The Author. Diabetic Medicine © 2013 Diabetes UK.

  8. Exploring memory hierarchy design with emerging memory technologies

    CERN Document Server

    Sun, Guangyu

    2014-01-01

    This book equips readers with tools for computer architecture of high performance, low power, and high reliability memory hierarchy in computer systems based on emerging memory technologies, such as STTRAM, PCM, FBDRAM, etc.  The techniques described offer advantages of high density, near-zero static power, and immunity to soft errors, which have the potential of overcoming the “memory wall.”  The authors discuss memory design from various perspectives: emerging memory technologies are employed in the memory hierarchy with novel architecture modification;  hybrid memory structure is introduced to leverage advantages from multiple memory technologies; an analytical model named “Moguls” is introduced to explore quantitatively the optimization design of a memory hierarchy; finally, the vulnerability of the CMPs to radiation-based soft errors is improved by replacing different levels of on-chip memory with STT-RAMs.   ·         Provides a holistic study of using emerging memory technologies i...

  9. The Ups and Downs of Hierarchy: the causes and consequences of hierarchy struggles and positional loss

    NARCIS (Netherlands)

    M.E. Schouten (Maartje)

    2016-01-01

    markdownabstractScholars have assumed that social hierarchies, the rank ordering of individuals with respect to a valued social dimension within a team, are stable over time. However, hierarchies change and the more changeable they are, the more likely they are to lead to conflicts and have other ne

  10. The Ups and Downs of Hierarchy: the causes and consequences of hierarchy struggles and positional loss

    NARCIS (Netherlands)

    M.E. Schouten (Maartje)

    2016-01-01

    markdownabstractScholars have assumed that social hierarchies, the rank ordering of individuals with respect to a valued social dimension within a team, are stable over time. However, hierarchies change and the more changeable they are, the more likely they are to lead to conflicts and have other

  11. On the Monadic Second-Order Transduction Hierarchy

    CERN Document Server

    Blumensath, Achim

    2010-01-01

    We compare classes of finite relational structures via monadic second-order transductions. More precisely, we study the preorder C <= K :iff C is a subset of tau(K) for some transduction tau. If we only consider classes of incidence structures we can completely describe the resulting hierarchy. It is linear of order type omega + 3. Each level can be characterised in terms of a suitable variant of tree-width. Canonical representatives of the various levels are: the class of all trees of height n, for each n in N, of all paths, of all trees, and of all grids.

  12. The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins.

    Science.gov (United States)

    Yatime, Laure; Betzer, Cristine; Jensen, Rasmus Kjeldsen; Mortensen, Sofia; Jensen, Poul Henning; Andersen, Gregers Rom

    2016-12-06

    S100 proteins are calcium-dependent regulators of homeostatic processes. Upon cellular response to stress, and notably during tumorigenesis, they relocalize to the extracellular environment where they induce pro-inflammatory signals by activating the receptor for advanced glycation end products (RAGE), thereby facilitating tumor growth and metastasis. Despite its importance in sustaining inflammation, the structural basis for RAGE-S100 crosstalk is still unknown. Here we report two crystal structures of the RAGE:S100A6 complex encompassing a full-length RAGE ectodomain. The structures, in combination with a comprehensive interaction analysis, suggest that the primary S100A6 binding site is formed by the RAGE C1 domain. Complex formation with S100A6 induces a unique dimeric conformation of RAGE that appears suited for signal transduction and intracellular effector recruitment. Intriguingly, S100A6 adopts a dimeric conformation radically different from all known S100 dimers. We discuss the physiological relevance of this non-canonical homodimeric form in vivo. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis.

    Science.gov (United States)

    Sleeman, Mark C; Sorensen, John L; Batchelar, Edward T; McDonough, Michael A; Schofield, Christopher J

    2005-10-14

    The first step in the biosynthesis of the medicinally important carbapenem family of beta-lactam antibiotics is catalyzed by carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily. CarB catalyzes formation of (2S,5S)-carboxymethylproline [(2S,5S)-t-CMP] from malonyl-CoA and l-glutamate semialdehyde. In addition to using a cosubstrate, CarB catalyzes C-C and C-N bond formation processes as well as an acyl-coenzyme A hydrolysis reaction. We describe the crystal structure of CarB in the presence and absence of acetyl-CoA at 2.24 A and 3.15 A resolution, respectively. The structures reveal that CarB contains a conserved oxy-anion hole probably required for decarboxylation of malonyl-CoA and stabilization of the resultant enolate. Comparison of the structures reveals that conformational changes (involving His(229)) in the cavity predicted to bind l-glutamate semialdehyde occur on (co)substrate binding. Mechanisms for the formation of the carboxymethylproline ring are discussed in the light of the structures and the accompanying studies using isotopically labeled substrates; cyclization via 1,4-addition is consistent with the observed labeling results (providing that hydrogen exchange at the C-6 position of carboxymethylproline does not occur). The side chain of Glu(131) appears to be positioned to be involved in hydrolysis of the carboxymethylproline-CoA ester intermediate. Labeling experiments ruled out the possibility that hydrolysis proceeds via an anhydride in which water attacks a carbonyl derived from Glu(131), as proposed for 3-hydroxyisobutyryl-CoA hydrolase. The structural work will aid in mutagenesis studies directed at altering the selectivity of CarB to provide intermediates for the production of clinically useful carbapenems.

  14. Mirror quintic vacua: hierarchies and inflation

    Science.gov (United States)

    Bizet, Nana Cabo; Loaiza-Brito, Oscar; Zavala, Ivonne

    2016-10-01

    We study the moduli space of type IIB string theory flux compactifications on the mirror of the CY quintic 3-fold in P^4 . We focus on the dynamics of the four dimensional moduli space, defined by the axio-dilaton τ and the complex structure modulus z. The z-plane has critical points, the conifold, the orbifold and the large complex structure with non trivial monodromies. We find the solutions to the Picard-Fuchs equations obeyed by the periods of the CY in the full z-plane as a series expansion in z around the critical points to arbitrary order. This allows us to discard fake vacua, which appear as a result of keeping only the leading order term in the series expansions. Due to monodromies vacua are located at a given sheet in the z-plane. A dS vacuum appears for a set of fluxes. We revisit vacua with hierarchies among the 4D and 6D physical scales close to the conifold point and compare them with those found at leading order in [1, 2]. We explore slow-roll inflationary directions of the scalar potential by looking at regions where the multi-field slow-roll parameters ɛ and η are smaller than one. The value of ɛ depends strongly on the approximation of the periods and to achieve a stable value, several orders in the expansion are needed. We do not find realizations of single field axion monodromy inflation. Instead, we find that inflationary regions appear along linear combinations of the four real field directions and for certain configurations of fluxes.

  15. Mirror quintic vacua: hierarchies and inflation

    Energy Technology Data Exchange (ETDEWEB)

    Bizet, Nana Cabo [Mandelstam Institute for Theoretical Physics, School of Physics,and NITheP, University of the Witwatersrand, WITS 2050, Johannesburg (South Africa); Departamento de Física, Universidad de Guanajuato,Loma del Bosque 103, CP 37150, León, Guanajuato (Mexico); Loaiza-Brito, Oscar [Departamento de Física, Universidad de Guanajuato,Loma del Bosque 103, CP 37150, León, Guanajuato (Mexico); Zavala, Ivonne [Department of Physics, Swansea University, Singleton Park,Swansea, SA2 8PP (United Kingdom)

    2016-10-17

    We study the moduli space of type IIB string theory flux compactifications on the mirror of the CY quintic 3-fold in ℙ{sup 4}. We focus on the dynamics of the four dimensional moduli space, defined by the axio-dilaton τ and the complex structure modulus z. The z-plane has critical points, the conifold, the orbifold and the large complex structure with non trivial monodromies. We find the solutions to the Picard-Fuchs equations obeyed by the periods of the CY in the full z-plane as a series expansion in z around the critical points to arbitrary order. This allows us to discard fake vacua, which appear as a result of keeping only the leading order term in the series expansions. Due to monodromies vacua are located at a given sheet in the z-plane. A dS vacuum appears for a set of fluxes. We revisit vacua with hierarchies among the 4D and 6D physical scales close to the conifold point and compare them with those found at leading order in http://dx.doi.org/10.1103/PhysRevD.66.106006, http://dx.doi.org/10.1007/JHEP03(2011)119. We explore slow-roll inflationary directions of the scalar potential by looking at regions where the multi-field slow-roll parameters ϵ and η are smaller than one. The value of ϵ depends strongly on the approximation of the periods and to achieve a stable value, several orders in the expansion are needed. We do not find realizations of single field axion monodromy inflation. Instead, we find that inflationary regions appear along linear combinations of the four real field directions and for certain configurations of fluxes.

  16. The Atypical Response Regulator Protein ChxR Has Structural Characteristics and Dimer Interface Interactions That Are Unique within the OmpR/PhoB Subfamily

    Energy Technology Data Exchange (ETDEWEB)

    Hickey, John M.; Lovell, Scott; Battaile, Kevin P.; Hu, Lei; Middaugh, C. Russell; Hefty, P. Scott (Kansas); (HWMRI)

    2013-05-29

    Typically as a result of phosphorylation, OmpR/PhoB response regulators form homodimers through a receiver domain as an integral step in transcriptional activation. Phosphorylation stabilizes the ionic and hydrophobic interactions between monomers. Recent studies have shown that some response regulators retain functional activity in the absence of phosphorylation and are termed atypical response regulators. The two currently available receiver domain structures of atypical response regulators are very similar to their phospho-accepting homologs, and their propensity to form homodimers is generally retained. An atypical response regulator, ChxR, from Chlamydia trachomatis, was previously reported to form homodimers; however, the residues critical to this interaction have not been elucidated. We hypothesize that the intra- and intermolecular interactions involved in forming a transcriptionally competent ChxR are distinct from the canonical phosphorylation (activation) paradigm in the OmpR/PhoB response regulator subfamily. To test this hypothesis, structural and functional studies were performed on the receiver domain of ChxR. Two crystal structures of the receiver domain were solved with the recently developed method using triiodo compound I3C. These structures revealed many characteristics unique to OmpR/PhoB subfamily members: typical or atypical. Included was the absence of two {alpha}-helices present in all other OmpR/PhoB response regulators. Functional studies on various dimer interface residues demonstrated that ChxR forms relatively stable homodimers through hydrophobic interactions, and disruption of these can be accomplished with the introduction of a charged residue within the dimer interface. A gel shift study with monomeric ChxR supports that dimerization through the receiver domain is critical for interaction with DNA.

  17. Cohesion and Hierarchy in Physically Abusive Families

    Directory of Open Access Journals (Sweden)

    Clarissa De Antoni

    2009-06-01

    Full Text Available This paper investigates cohesion (emotional bonding and hierarchy (powerstructure in families with abuse against their children. Twenty low-incomefamilies participated. Father, mother and child’s perspective of family relations(cohesion and hierarchy were evaluated by the Family System Test(FAST. The relationship between father-child, mother-child, couple, andamong siblings were evaluated at typical and conflictive situations. Resultsshow a significance regarding to cohesion in typical and conflictive situationfor father-child and mother-child dyads in all perspectives (by father, mother,and child. There is no significant differences regarding to hierarchy. Theseresults suggest that the families see the intrafamilial violence as a constant,since they cannot differentiate between both situations.

  18. The mammary cellular hierarchy and breast cancer.

    Science.gov (United States)

    Oakes, Samantha R; Gallego-Ortega, David; Ormandy, Christopher J

    2014-11-01

    Advances in the study of hematopoietic cell maturation have paved the way to a deeper understanding the stem and progenitor cellular hierarchy in the mammary gland. The mammary epithelium, unlike the hematopoietic cellular hierarchy, sits in a complex niche where communication between epithelial cells and signals from the systemic hormonal milieu, as well as from extra-cellular matrix, influence cell fate decisions and contribute to tissue homeostasis. We review the discovery, definition and regulation of the mammary cellular hierarchy and we describe the development of the concepts that have guided our investigations. We outline recent advances in in vivo lineage tracing that is now challenging many of our assumptions regarding the behavior of mammary stem cells, and we show how understanding these cellular lineages has altered our view of breast cancer.

  19. Formal language theory: refining the Chomsky hierarchy

    Science.gov (United States)

    Jäger, Gerhard; Rogers, James

    2012-01-01

    The first part of this article gives a brief overview of the four levels of the Chomsky hierarchy, with a special emphasis on context-free and regular languages. It then recapitulates the arguments why neither regular nor context-free grammar is sufficiently expressive to capture all phenomena in the natural language syntax. In the second part, two refinements of the Chomsky hierarchy are reviewed, which are both relevant to the extant research in cognitive science: the mildly context-sensitive languages (which are located between context-free and context-sensitive languages), and the sub-regular hierarchy (which distinguishes several levels of complexity within the class of regular languages). PMID:22688632

  20. Transitivity performance, relational hierarchy knowledge and awareness: results of an instructional framing manipulation.

    Science.gov (United States)

    Kumaran, Dharshan; Ludwig, Hans

    2013-12-01

    The transitive inference (TI) paradigm has been widely used to examine the role of the hippocampus in generalization. Here we consider a surprising feature of experimental findings in this task: the relatively poor transitivity performance and levels of hierarchy knowledge achieved by adult human subjects. We focused on the influence of the task instructions on participants' subsequent performance--a single-word framing manipulation which either specified the relation between items as transitive (i.e., OLD-FRAME: choose which item is "older") or left it ambiguous (i.e., NO-FRAME: choose which item is "correct"). We show a marked but highly specific effect of manipulating prior knowledge through instruction: transitivity performance and levels of relational hierarchy knowledge were enhanced, but premise performance unchanged. Further, we show that hierarchy recall accuracy, but not conventional awareness scores, was a significant predictor of inferential performance across the entire group of participants. The current study has four main implications: first, our findings establish the importance of the task instructions, and prior knowledge, in the TI paradigm--suggesting that they influence the size of the overall hypothesis space (e.g., to favor a linear hierarchical structure over other possibilities in the OLD-FRAME). Second, the dissociable effects of the instructional frame on premise and inference performance provide evidence for the operation of distinct underlying mechanisms (i.e., an associative mechanism vs. relational hierarchy knowledge). Third, our findings suggest that a detailed measurement of hierarchy recall accuracy may be a more sensitive index of relational hierarchy knowledge, than conventional awareness score--and should be used in future studies investigating links between awareness and inferential performance. Finally, our study motivates an experimental setting that ensures robust hierarchy learning across participants

  1. A High-Resolution Crystal Structure of a Psychrohalophilic α–Carbonic Anhydrase from Photobacterium profundum Reveals a Unique Dimer Interface

    Energy Technology Data Exchange (ETDEWEB)

    Somalinga, Vijayakumar; Buhrman, Greg; Arun, Ashikha; Rose, Robert B.; Grunden, Amy M. (NCSU)

    2016-12-09

    Bacterial α–carbonic anhydrases (α-CA) are zinc containing metalloenzymes that catalyze the rapid interconversion of CO2 to bicarbonate and a proton. We report the first crystal structure of a pyschrohalophilic α–CA from a deep-sea bacterium, Photobacterium profundum. Size exclusion chromatography of the purified P. profundum α–CA (PprCA) reveals that the protein is a heterogeneous mix of monomers and dimers. Furthermore, an “in-gel” carbonic anhydrase activity assay, also known as protonography, revealed two distinct bands corresponding to monomeric and dimeric forms of PprCA that are catalytically active. The crystal structure of PprCA was determined in its native form and reveals a highly conserved “knot-topology” that is characteristic of α–CA’s. Similar to other bacterial α–CA’s, PprCA also crystallized as a dimer. Furthermore, dimer interface analysis revealed the presence of a chloride ion (Cl-) in the interface which is unique to PprCA and has not been observed in any other α–CA’s characterized so far. Molecular dynamics simulation and chloride ion occupancy analysis shows 100% occupancy for the Cl- ion in the dimer interface. Zinc coordinating triple histidine residues, substrate binding hydrophobic patch residues, and the hydrophilic proton wire residues are highly conserved in PprCA and are identical to other well-studied α–CA’s.

  2. Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism.

    Science.gov (United States)

    Murray, David S; Chinnam, Nagababu; Tonthat, Nam Ky; Whitfill, Travis; Wray, Lewis V; Fisher, Susan H; Schumacher, Maria A

    2013-12-13

    Glutamine synthetase (GS), which catalyzes the production of glutamine, plays essential roles in nitrogen metabolism. There are two main bacterial GS isoenzymes, GSI-α and GSI-β. GSI-α enzymes, which have not been structurally characterized, are uniquely feedback-inhibited by Gln. To gain insight into GSI-α function, we performed biochemical and cellular studies and obtained structures for all GSI-α catalytic and regulatory states. GSI-α forms a massive 600-kDa dodecameric machine. Unlike other characterized GS, the Bacillus subtilis enzyme undergoes dramatic intersubunit conformational alterations during formation of the transition state. Remarkably, these changes are required for active site construction. Feedback inhibition arises from a hydrogen bond network between Gln, the catalytic glutamate, and the GSI-α-specific residue, Arg(62), from an adjacent subunit. Notably, Arg(62) must be ejected for proper active site reorganization. Consistent with these findings, an R62A mutation abrogates Gln feedback inhibition but does not affect catalysis. Thus, these data reveal a heretofore unseen restructuring of an enzyme active site that is coupled with an isoenzyme-specific regulatory mechanism. This GSI-α-specific regulatory network could be exploited for inhibitor design against Gram-positive pathogens.

  3. BiOI/TiO2 nanotube arrays, a unique flake-tube structured p-n junction with remarkable visible-light photoelectrocatalytic performance and stability.

    Science.gov (United States)

    Liu, Jiaqin; Ruan, Lili; Adeloju, Samuel B; Wu, Yucheng

    2014-01-28

    A series of unique flake-tube structured p-n heterojunctions of BiOI/TiO2 nanotube arrays (TNTAs) were successfully prepared by loading large amounts of BiOI nanoflakes onto both the outer and inner walls of well-separated TiO2 nanotubes using anodization followed by the sequential chemical bath deposition (S-CBD) method. The as-prepared BiOI/TNTAs samples were characterized by X-ray diffraction, electron microscopy, X-ray photoelectron spectroscopy, UV-vis diffuse reflectance spectroscopy and nitrogen sorption. The photoelectrocatalytic (PEC) activity and stability of the BiOI/TNTAs samples toward degradation of methyl orange (MO) solutions under visible-light irradiation (λ > 420 nm) were evaluated. The visible-light PEC performance of BiOI/TNTAs samples was further confirmed by the transient photocurrent response test. The results from the current study revealed that the 5-BiOI/TNTAs sample exhibited the best PEC activity, favourable stability, and the highest photocurrent density among all the BiOI/TNTAs heterostructured samples. The combined effects of several factors may contribute to the remarkable visible-light PEC performance for the 5-BiOI/TNTAs sample including a 3D connected intertube spacing system and an open tube-mouth structure, strong visible-light absorption by BiOI, the formation of a p-n junction, larger specific surface area, and the impact of the applied external electrostatic field.

  4. Cardiac contractility structure-activity relationship and ligand-receptor interactions; the discovery of unique and novel molecular switches in myosuppressin signaling.

    Directory of Open Access Journals (Sweden)

    Megan Leander

    Full Text Available Peptidergic signaling regulates cardiac contractility; thus, identifying molecular switches, ligand-receptor contacts, and antagonists aids in exploring the underlying mechanisms to influence health. Myosuppressin (MS, a decapeptide, diminishes cardiac contractility and gut motility. Myosuppressin binds to G protein-coupled receptor (GPCR proteins. Two Drosophila melanogaster myosuppressin receptors (DrmMS-Rs exist; however, no mechanism underlying MS-R activation is reported. We predicted DrmMS-Rs contained molecular switches that resembled those of Rhodopsin. Additionally, we believed DrmMS-DrmMS-R1 and DrmMS-DrmMS-R2 interactions would reflect our structure-activity relationship (SAR data. We hypothesized agonist- and antagonist-receptor contacts would differ from one another depending on activity. Lastly, we expected our study to apply to other species; we tested this hypothesis in Rhodnius prolixus, the Chagas disease vector. Searching DrmMS-Rs for molecular switches led to the discovery of a unique ionic lock and a novel 3-6 lock, as well as transmission and tyrosine toggle switches. The DrmMS-DrmMS-R1 and DrmMS-DrmMS-R2 contacts suggested tissue-specific signaling existed, which was in line with our SAR data. We identified R. prolixus (RhpMS-R and discovered it, too, contained the unique myosuppressin ionic lock and novel 3-6 lock found in DrmMS-Rs as well as transmission and tyrosine toggle switches. Further, these motifs were present in red flour beetle, common water flea, honey bee, domestic silkworm, and termite MS-Rs. RhpMS and DrmMS decreased R. prolixus cardiac contractility dose dependently with EC50 values of 140 nM and 50 nM. Based on ligand-receptor contacts, we designed RhpMS analogs believed to be an active core and antagonist; testing on heart confirmed these predictions. The active core docking mimicked RhpMS, however, the antagonist did not. Together, these data were consistent with the unique ionic lock, novel 3-6 lock

  5. Integrable couplings of a generalized AKNS hierarchy

    Institute of Scientific and Technical Information of China (English)

    张玉峰; 张鸿庆; 闫庆友

    2002-01-01

    A generalized AKNS isospectral problem where the trace of corresponding spectral matrix is not zero, is transformed to a new isospectral problem where the trace of the resulting matrix is zero, by using transformation of Lax pairs, and these two spectral problems lead to the same hierarchy of equations. The authors started from the transformed spectral problem and constructed a new loop algebra which has not appeared before, and obtained the integrable coupling of the generalized AKNS hierarchy. Specially, the integrable couplings of the KdV equation and MKdV equation are obtained.

  6. Structure of the human angiotensin II type 1 (AT1) receptor bound to angiotensin II from multiple chemoselective photoprobe contacts reveals a unique peptide binding mode.

    Science.gov (United States)

    Fillion, Dany; Cabana, Jérôme; Guillemette, Gaétan; Leduc, Richard; Lavigne, Pierre; Escher, Emanuel

    2013-03-22

    Breakthroughs in G protein-coupled receptor structure determination based on crystallography have been mainly obtained from receptors occupied in their transmembrane domain core by low molecular weight ligands, and we have only recently begun to elucidate how the extracellular surface of G protein-coupled receptors (GPCRs) allows for the binding of larger peptide molecules. In the present study, we used a unique chemoselective photoaffinity labeling strategy, the methionine proximity assay, to directly identify at physiological conditions a total of 38 discrete ligand/receptor contact residues that form the extracellular peptide-binding site of an activated GPCR, the angiotensin II type 1 receptor. This experimental data set was used in homology modeling to guide the positioning of the angiotensin II (AngII) peptide within several GPCR crystal structure templates. We found that the CXC chemokine receptor type 4 accommodated the results better than the other templates evaluated; ligand/receptor contact residues were spatially grouped into defined interaction clusters with AngII. In the resulting receptor structure, a β-hairpin fold in extracellular loop 2 in conjunction with two extracellular disulfide bridges appeared to open and shape the entrance of the ligand-binding site. The bound AngII adopted a somewhat vertical binding mode, allowing concomitant contacts across the extracellular surface and deep within the transmembrane domain core of the receptor. We propose that such a dualistic nature of GPCR interaction could be well suited for diffusible linear peptide ligands and a common feature of other peptidergic class A GPCRs.

  7. Structure of the Human Angiotensin II Type 1 (AT1) Receptor Bound to Angiotensin II from Multiple Chemoselective Photoprobe Contacts Reveals a Unique Peptide Binding Mode*

    Science.gov (United States)

    Fillion, Dany; Cabana, Jérôme; Guillemette, Gaétan; Leduc, Richard; Lavigne, Pierre; Escher, Emanuel

    2013-01-01

    Breakthroughs in G protein-coupled receptor structure determination based on crystallography have been mainly obtained from receptors occupied in their transmembrane domain core by low molecular weight ligands, and we have only recently begun to elucidate how the extracellular surface of G protein-coupled receptors (GPCRs) allows for the binding of larger peptide molecules. In the present study, we used a unique chemoselective photoaffinity labeling strategy, the methionine proximity assay, to directly identify at physiological conditions a total of 38 discrete ligand/receptor contact residues that form the extracellular peptide-binding site of an activated GPCR, the angiotensin II type 1 receptor. This experimental data set was used in homology modeling to guide the positioning of the angiotensin II (AngII) peptide within several GPCR crystal structure templates. We found that the CXC chemokine receptor type 4 accommodated the results better than the other templates evaluated; ligand/receptor contact residues were spatially grouped into defined interaction clusters with AngII. In the resulting receptor structure, a β-hairpin fold in extracellular loop 2 in conjunction with two extracellular disulfide bridges appeared to open and shape the entrance of the ligand-binding site. The bound AngII adopted a somewhat vertical binding mode, allowing concomitant contacts across the extracellular surface and deep within the transmembrane domain core of the receptor. We propose that such a dualistic nature of GPCR interaction could be well suited for diffusible linear peptide ligands and a common feature of other peptidergic class A GPCRs. PMID:23386604

  8. Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy.

    Science.gov (United States)

    Alcorlo, Martin; Martínez-Barricarte, Ruben; Fernández, Francisco J; Rodríguez-Gallego, César; Round, Adam; Vega, M Cristina; Harris, Claire L; de Cordoba, Santiago Rodríguez; Llorca, Oscar

    2011-08-01

    Activation of C3, deposition of C3b on the target surface, and subsequent amplification by formation of a C3-cleaving enzyme (C3-convertase; C3bBb) triggers the effector functions of complement that result in inflammation and cell lysis. Concurrently, surface-bound C3b is proteolyzed to iC3b by factor I and appropriate cofactors. iC3b then interacts with the complement receptors (CR) of the Ig superfamily, CR2 (CD21), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) on leukocytes, down-modulating inflammation, enhancing B cell-mediated immunity, and targeting pathogens for clearance by phagocytosis. Using EM and small-angle X-ray scattering, we now present a medium-resolution structure of iC3b (24 Å). iC3b displays a unique conformation with structural features distinct from any other C3 fragment. The macroglobulin ring in iC3b is similar to that in C3b, whereas the TED (thioester-containing domain) domain and the remnants of the CUB (complement protein subcomponents C1r/C1s, urchin embryonic growth factor and bone morphogenetic protein 1) domain have moved to locations more similar to where they were in native C3. A consequence of this large conformational change is the disruption of the factor B binding site, which renders iC3b unable to assemble a C3-convertase. This structural model also justifies the decreased interaction between iC3b and complement regulators and the recognition of iC3b by the CR of the Ig superfamily, CR2, CR3, and CR4. These data further illustrate the extraordinary conformational versatility of C3 to accommodate a great diversity of functional activities.

  9. Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

    Science.gov (United States)

    Alcorlo, Martin; Martínez-Barricarte, Ruben; Fernández, Francisco J.; Rodríguez-Gallego, César; Round, Adam; Vega, M. Cristina; Harris, Claire L.; de Cordoba, Santiago Rodríguez; Llorca, Oscar

    2011-01-01

    Activation of C3, deposition of C3b on the target surface, and subsequent amplification by formation of a C3-cleaving enzyme (C3-convertase; C3bBb) triggers the effector functions of complement that result in inflammation and cell lysis. Concurrently, surface-bound C3b is proteolyzed to iC3b by factor I and appropriate cofactors. iC3b then interacts with the complement receptors (CR) of the Ig superfamily, CR2 (CD21), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) on leukocytes, down-modulating inflammation, enhancing B cell-mediated immunity, and targeting pathogens for clearance by phagocytosis. Using EM and small-angle X-ray scattering, we now present a medium-resolution structure of iC3b (24 Å). iC3b displays a unique conformation with structural features distinct from any other C3 fragment. The macroglobulin ring in iC3b is similar to that in C3b, whereas the TED (thioester-containing domain) domain and the remnants of the CUB (complement protein subcomponents C1r/C1s, urchin embryonic growth factor and bone morphogenetic protein 1) domain have moved to locations more similar to where they were in native C3. A consequence of this large conformational change is the disruption of the factor B binding site, which renders iC3b unable to assemble a C3-convertase. This structural model also justifies the decreased interaction between iC3b and complement regulators and the recognition of iC3b by the CR of the Ig superfamily, CR2, CR3, and CR4. These data further illustrate the extraordinary conformational versatility of C3 to accommodate a great diversity of functional activities. PMID:21788512

  10. On the hierarchy of partially invariant submodels of differential equations

    Energy Technology Data Exchange (ETDEWEB)

    Golovin, Sergey V [Lavrentyev Institute of Hydrodynamics SB RAS, Novosibirsk 630090 (Russian Federation)], E-mail: sergey@hydro.nsc.ru

    2008-07-04

    It is noted that the partially invariant solution (PIS) of differential equations in many cases can be represented as an invariant reduction of some PISs of the higher rank. This introduces a hierarchic structure in the set of all PISs of a given system of differential equations. An equivalence of the two-step and the direct ways of construction of PISs is proved. The hierarchy simplifies the process of enumeration and analysis of partially invariant submodels to the given system of differential equations. In this framework, the complete classification of regular partially invariant solutions of ideal MHD equations is given.

  11. Two Expanding Integrable Models of the Geng-Cao Hierarchy

    Directory of Open Access Journals (Sweden)

    Xiurong Guo

    2014-01-01

    interesting results. In the paper, we will deduce two kinds of expanding integrable models of the Geng-Cao (GC hierarchy by constructing different 6-dimensional Lie algebras. One expanding integrable model (actually, it is a nonlinear integrable coupling reduces to a generalized Burgers equation and further reduces to the heat equation whose expanding nonlinear integrable model is generated. Another one is an expanding integrable model which is different from the first one. Finally, the Hamiltonian structures of the two expanding integrable models are obtained by employing the variational identity and the trace identity, respectively.

  12. Lagrangian Approach to Dispersionless KdV Hierarchy

    Directory of Open Access Journals (Sweden)

    Amitava Choudhuri

    2007-09-01

    Full Text Available We derive a Lagrangian based approach to study the compatible Hamiltonian structure of the dispersionless KdV and supersymmetric KdV hierarchies and claim that our treatment of the problem serves as a very useful supplement of the so-called r-matrix method. We suggest specific ways to construct results for conserved densities and Hamiltonian operators. The Lagrangian formulation, via Noether's theorem, provides a method to make the relation between symmetries and conserved quantities more precise. We have exploited this fact to study the variational symmetries of the dispersionless KdV equation.

  13. Spatial hierarchy and emerging typologies inside world city network

    Directory of Open Access Journals (Sweden)

    Chubarov Ilya

    2015-12-01

    Full Text Available The first part of the paper provides a new approach to measuring a spatial structure of world city network (WCN. Based upon the results of media- popular ‘global city rankings’ produced by several international think tanks, our calculation allowed to reveal global urban hierarchy and identify several subnetworks inside of world cities. The second part of the paper devotes to recent discussions on nature of globalization and urban macrosystems, bearing in mind ranking results. It is shown that a typological approach can provide more insights to a role of city as part of WCN from functional and relationships prospective.

  14. Power at work: navigating hierarchies, teamwork and webs.

    Science.gov (United States)

    DiPalma, Carolyn

    2004-01-01

    I explore tensions between the dynamics observed during a shadowing experience in a clinic and a hospital and theories of power and organizations. Commenting on what the tensions reveal about "power at work" (in the dual sense of how power works and power in the workplace), I suggest that some of the most gratifying experiences of workplace collaboration for healthcare professionals may occur as a result of their having successfully navigated complex coalitions of hierarchies, teams and webs rather than dutifully adhering to any single organizational structure.

  15. Authority and Hierarchy within Anonymous Internet Relay Chat Networks

    Directory of Open Access Journals (Sweden)

    Stewart Kenton Bertram

    2015-09-01

    Full Text Available 'The protest group Anonymous has emerged as one of the most significant social movements of recent years, announcing their arrival as a globally recognized brand with regular disruptive cyber attacks and the leak of large volumes of sensitive data. Despite the obvious significance of Anonymous, to date, little academic research has been focused on what role hierarchy and internal authority play (if any within the group. Bespoke software was used to structure over 5000 examples of IRC log files, so that a base line descriptive statistical picture could be drawn, as well as a more granular enumeration of the privileges associated with individual users.'

  16. A Model of Quark and Lepton Mixing and Mass Hierarchy

    CERN Document Server

    Barr, S M

    2015-01-01

    It is shown that an idea proposed in 1996 that relates in a qualitatively correct way the inter-family mass hierarchies of the up quarks, down quarks, charged leptons, and neutrinos, can be combined with a predictive scheme recently proposed for relating quark mixing and neutrino mixing. In the resulting model, the entire flavor structure of the quarks and leptons is expressible in terms of two "master matrices": a diagonal matrix that gives the inter-family mass ratios, and an off-diagonal matrix that controls all flavor mixing.

  17. Breaking through the Glass Ceiling: Consumers in Mental Health Organisations' Hierarchies.

    Science.gov (United States)

    Scholz, Brett; Bocking, Julia; Happell, Brenda

    2017-05-01

    Contemporary mental health policies call for consumers to be engaged in all levels of mental health service planning, implementation, and delivery. Critical approaches to traditional healthcare hierarchies can effectively challenge barriers to better engagement with consumers in mental health organisations. This qualitative exploratory study analyses how particular strategies for consumer leadership facilitate or hinder relationships between consumers and mental health services, and how these strategies influence hierarchical structures. Fourteen participants from a range of mental health organisations were interviewed. These interviews were analysed using thematic analytic and discursive psychological techniques. The findings highlight several benefits of having consumers within mental health organisational hierarchies, and elaborate on ways that employees within mental health services can support integration of consumers into existing hierarchies. Specific barriers to consumers in hierarchies are discussed, including a lack of clarity of structures and roles within hierarchies, and resistance to consumers reaching the highest levels of leadership within organisations. Alternative hierarchical models which privilege consumers' control over resources and power are also discussed. Mental health organisations are encouraged to integrate consumer leaders into their hierarchical structures to improve their organisational offerings, their reputation, and their service innovation.

  18. Large hierarchies from approximate R symmetries

    Energy Technology Data Exchange (ETDEWEB)

    Kappl, Rolf; Ratz, Michael [Technische Univ. Muenchen, Garching (Germany). Physik Dept. T30; Nilles, Hans Peter [Bonn Univ. (Germany). Bethe Zentrum fuer Theoretische Physik und Physikalisches Inst.; Ramos-Sanchez, Saul; Schmidt-Hoberg, Kai [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Vaudrevange, Patrick K.S. [Ludwig-Maximilians-Univ. Muenchen (Germany). Arnold Sommerfeld Zentrum fuer Theoretische Physik

    2008-12-15

    We show that hierarchically small vacuum expectation values of the superpotential in supersymmetric theories can be a consequence of an approximate R symmetry. We briefly discuss the role of such small constants in moduli stabilization and understanding the huge hierarchy between the Planck and electroweak scales. (orig.)

  19. Integrable hierarchies of Heisenberg ferromagnet equation

    Science.gov (United States)

    Nugmanova, G.; Azimkhanova, A.

    2016-08-01

    In this paper we consider the coupled Kadomtsev-Petviashvili system. From compatibility conditions we obtain the form of matrix operators. After using a gauge transformation, obtained a new type of Lax representation for the hierarchy of Heisenberg ferromagnet equation, which is equivalent to the gauge coupled Kadomtsev-Petviashvili system.

  20. Geometrical hierarchy and spontaneous symmetry breaking

    Energy Technology Data Exchange (ETDEWEB)

    Farakos, K.; Koutsoumbas, G.; Surridge, M.; Zoupanos, G.

    1987-06-04

    A four-dimensional gauge theory, where Higgs fields and the corresponding potential appear naturally, is obtained by dimensionally reducing a pure gauge theory over a compact coset space S/R. We show, using an explicit example, that a hierarchy of the scales in the coset space can change the spontaneous symmetry breaking of the four-dimensional gauge theory.

  1. Beyond Hierarchy: The Search for High Performance.

    Science.gov (United States)

    Galagan, Patricia A.; And Others

    1992-01-01

    This special report of the reorganization of work looks at approaches to organizational renewal that are challenging the notion of the hierarchy as the only form that works. Looks at models for organizing work presented by Gary Rummler, D. Quinn Mills, and Marvin Weisbord and a blueprint for creating common futures with large groups of people.…

  2. Dark energy and the hierarchy problem

    CERN Document Server

    Chen, P

    2007-01-01

    The well-known hierarchy between the Planck scale (~10^{19}GeV) and the TeV scale, namely a ratio of ~10^{16} between the two, is coincidentally repeated in a inverted order between the TeV scale and the dark energy scale at \\~10^{-3}eV implied by the observations. We argue that this is not a numerical coincidence. The same brane-world setups to address the first hierarchy problem may also in principle address this second hierarchy issue. Specifically, we consider supersymmetry in the bulk and its breaking on the brane and resort to the Casimir energy induced by the bulk graviton-gravitino mass-shift on the brane as the dark energy. For the ADD model we found that our notion is sensible only if the number of extra dimension n=2. We extend our study to the Randall-Sundrum model. Invoking the chirality-flip on the boundaries for SUSY-breaking, the zero-mode gravitino contribution to the Casimir energy does give rise to the double hierarchy. Unfortunately since the higher Kaluza-Klein modes acquire relative mass...

  3. Beyond Hierarchy: The Search for High Performance.

    Science.gov (United States)

    Galagan, Patricia A.; And Others

    1992-01-01

    This special report of the reorganization of work looks at approaches to organizational renewal that are challenging the notion of the hierarchy as the only form that works. Looks at models for organizing work presented by Gary Rummler, D. Quinn Mills, and Marvin Weisbord and a blueprint for creating common futures with large groups of people.…

  4. Self-organization of divided hierarchy

    Science.gov (United States)

    Odagaki, Takashi; Kitada, Keigo; Omizo, Kenta; Fujie, Ryo

    2015-03-01

    There are two types of extreme form of hierarchy, one is the plutonomy where small fraction of winners and losers and many people in the middle class appear and the other a divided hierarchy where half of population become winners and the remaining half become losers. We study the emergence of the divided hierarchy in a model society which consists of bellicose individuals who always try to fight and fight with the strongest neighbor and pacific individuals who always try not to fight and when necessary fight with the weakest neighbor. In our model society, (1) individuals make random walk on a square lattice, (2) when two individuals encounter they fight each other and (3) the winner deprives wealth from the loser. By a Monte Carlo simulation, we show that there are two transitions when the population density is increased; one is a transition from the egalitarian society to a hierarchical society I where winners, losers and middle classes coexist and the other is a transition from the hierarchical society I to a hierarchical society II where winners and losers exist but no middle classes exist, that is the divided hierarchy. We also show that clusters consisting mostly of bellicose individuals appear in the hierarchical society I.

  5. The FO^2 alternation hierarchy is decidable

    CERN Document Server

    Kufleitner, Manfred

    2012-01-01

    We consider the two-variable fragment FO^2[<] of first-order logic over finite words. Numerous characterizations of this class are known. Th\\'erien and Wilke have shown that it is decidable whether a given regular language is definable in FO^2[<]. From a practical point of view, as shown by Weis, FO^2[<] is interesting since its satisfiability problem is in NP. Restricting the number of quantifier alternations yields an infinite hierarchy inside the class of FO^2[<]-definable languages. We show that each level of this hierarchy is decidable. For this purpose, we relate each level of the hierarchy with a decidable variety of finite monoids. Our result implies that there are many different ways of climbing up the FO^2[<]-quantifier alternation hierarchy: deterministic and co-deterministic products, Mal'cev products with definite and reverse definite semigroups, iterated block products with J-trivial monoids, and some inductively defined omega-term identities. A combinatorial tool in the process o...

  6. Using Analytic Hierarchy Process in Textbook Evaluation

    Science.gov (United States)

    Kato, Shigeo

    2014-01-01

    This study demonstrates the application of the analytic hierarchy process (AHP) in English language teaching materials evaluation, focusing in particular on its potential for systematically integrating different components of evaluation criteria in a variety of teaching contexts. AHP is a measurement procedure wherein pairwise comparisons are made…

  7. The Analytic Hierarchy Process and Participatory Decisionmaking

    Science.gov (United States)

    Daniel L. Schmoldt; Daniel L. Peterson; Robert L. Smith

    1995-01-01

    Managing natural resource lands requires social, as well as biophysical, considerations. Unfortunately, it is extremely difficult to accurately assess and quantify changing social preferences, and to aggregate conflicting opinions held by diverse social groups. The Analytic Hierarchy Process (AHP) provides a systematic, explicit, rigorous, and robust mechanism for...

  8. Primary structure and phosphorylation of dentin matrix protein 1 (DMP1) and dentin phosphophoryn (DPP) uniquely determine their role in biomineralization.

    Science.gov (United States)

    Deshpande, Atul Suresh; Fang, Ping-An; Zhang, Xiaoyuan; Jayaraman, Thottala; Sfeir, Charles; Beniash, Elia

    2011-08-08

    The SIBLING (small integrin-binding ligand N-linked glycoproteins) family is the major group of noncollagenous proteins in bone and dentin. These extremely acidic and highly phosphorylated extracellular proteins play critical roles in the formation of collagenous mineralized tissues. Whereas the lack of individual SIBLINGs causes significant mineralization defects in vivo, none of them led to a complete cessation of mineralization suggesting that these proteins have overlapping functions. To assess whether different SIBLINGs regulate biomineralization in a similar manner and how phosphorylation impacts their activity, we studied the effects of two SIBLINGs, dentin matrix protein 1 (DMP1) and dentin phosphophoryn (DPP), on mineral morphology and organization in vitro. Our results demonstrate distinct differences in the effects of these proteins on mineralization. We show that phosphorylation has a profound effect on the regulation of mineralization by both proteins. Specifically, both phosphorylated proteins facilitated organized mineralization of collagen fibrils and phosphorylated DMP1-induced formation of organized mineral bundles in the absence of collagen. In summary, these results indicate that the primary structure and phosphorylation uniquely determine functions of individual SIBLINGs in regulation of mineral morphology and organization.

  9. Unique structural properties of 2,4,6-tri-tert-butylanilide: isomerization and switching between separable amide rotamers through the reaction of anilide enolates.

    Science.gov (United States)

    Tsukagoshi, Shiori; Ototake, Nobutaka; Ohnishi, Yusuke; Shimizu, Mayu; Kitagawa, Osamu

    2013-05-17

    Herein, we report a unique structural property of 2,4,6-tri-tert-butylanilide, which can be separated into its amide rotamers at room temperature. Interconversion between the rotamers of anilide enolates occurs readily at room temperature and their reaction with electrophiles gives mixtures of the rotamers in a ratio that depends on the reactivity of the corresponding electrophile. That is, the reaction of the 2,4,6-tri-tert-butylacetanilide enolate with reactive electrophiles, such as allyl bromide or protic acids, gives mixtures of the anilide rotamers in which the E rotamer is the major component, whereas less-reactive electrophiles, such as 1-bromopropane and 2-iodopropane, yield mixtures of the rotamers in which the Z rotamer is the major component. The rotameric ratio of the product is also strongly dependent on the reactivity of the anilide enolate. Switching between the anilide rotamers can be achieved through protonation of a less-reactive enolate by a less-reactive protic acid and thermal isomerization of the anilide.

  10. Nanoporous PdZr surface alloy as highly active non-platinum electrocatalyst toward oxygen reduction reaction with unique structure stability and methanol-tolerance

    Science.gov (United States)

    Duan, Huimei; Xu, Caixia

    2016-06-01

    Nanoporous (NP) PdZr alloy with controllable bimetallic ratio is successfully fabricated by a simple dealloying method. By leaching out the more reactive Al from PdZrAl precursor alloy, NP-PdZr alloy with smaller ligament size was generated, characterized by the nanoscaled interconnected network skeleton and hollow channels extending in all three dimensions. Upon voltammetric scan in acid solution, the dissolution of surface Zr atoms generates the highly active Pd-Zr surface alloy with a nearly pure Pd surface and Pd-Zr alloy core. The NP-Pd80Zr20 surface alloy exhibits markedly enhanced specific and mass activities as well as higher catalytic stability toward oxygen reduction reaction (ORR) compared with NP-Pd and the state-of-the-art Pt/C catalysts. In addition, the NP-Pd80Zr20 surface alloy shows a better selectivity for ORR than methanol in the 0.1 M HClO4 and 0.1 M methanol mixed solution. X-ray photoelectron spectroscopy and density functional theory calculations both demonstrate that the weakened Pd-O bond and improved ORR performances in turn depend on the downshifted d-band center of Pd due to the alloying Pd with Zr (20 at.%). The as-made NP-PdZr alloy holds prospective applications as a cathode electrocatalyst in fuel-cell-related technologies with the advantages of superior overall ORR performances, unique structure stability, and easy preparation.

  11. Formation of a unique cluster of G-quadruplex structures in the HIV-1 Nef coding region: implications for antiviral activity.

    Directory of Open Access Journals (Sweden)

    Rosalba Perrone

    Full Text Available G-quadruplexes are tetraplex structures of nucleic acids that can form in G-rich sequences. Their presence and functional role have been established in telomeres, oncogene promoters and coding regions of the human chromosome. In particular, they have been proposed to be directly involved in gene regulation at the level of transcription. Because the HIV-1 Nef protein is a fundamental factor for efficient viral replication, infectivity and pathogenesis in vitro and in vivo, we investigated G-quadruplex formation in the HIV-1 nef gene to assess the potential for viral inhibition through G-quadruplex stabilization. A comprehensive computational analysis of the nef coding region of available strains showed the presence of three conserved sequences that were uniquely clustered. Biophysical testing proved that G-quadruplex conformations were efficiently stabilized or induced by G-quadruplex ligands in all three sequences. Upon incubation with a G-quadruplex ligand, Nef expression was reduced in a reporter gene assay and Nef-dependent enhancement of HIV-1 infectivity was significantly repressed in an antiviral assay. These data constitute the first evidence of the possibility to regulate HIV-1 gene expression and infectivity through G-quadruplex targeting and therefore open a new avenue for viral treatment.

  12. Sociality, hierarchy, health comparative biodemography: a collection of papers

    National Research Council Canada - National Science Library

    Weinstein, Maxine; Lane, Meredith A

    2014-01-01

    "Sociality, Hierarchy, Health: Comparative Biodemography is a collection of papers that examine cross-species comparisons of social environments with a focus on social behaviors along with social hierarchies and connections...

  13. FIXING THE ONTOLOGICAL HIERARCHY IN ANCIENT GREEK EPIC

    Directory of Open Access Journals (Sweden)

    Vasiljeva A. S.

    2015-05-01

    Full Text Available The article is devoted to the analysis of representations of hierarchical structure of the universe in ancient Greek mythic-epic tradition. In the research there was shown that the myth reflects the main program of interpretation of main principles of the universe by a man in its structure; the Chaos in itself possesses the generative power and forms an order from itself but the hierarchy appears together with the formation of the order-outer space. The first deities – Gaea and born from her Uranus, mountains, Pontus, - possess the great power and in the first place, the power of generation. From works of Gomer and Gesiodus we ascertained that the history of gods was connected with the fight of children with the father-sovereign. One generation of gods became that support on which the other stands. The third generation of gods is sovereigns in greater extent than another one. The generation of Titans is implacable but lives according to unlimited forces of nature. Titans are unbridled. Gods-Olympians, on contrary, have the relation to conscious restriction. Gods of the third generation possess passions: love, hate. However, Olympians as well as humans must submit to transcendental law of the universe. Gods of the third generation join to the rationale. The order of the universe submitted to the law – Destiny is disseminated in human community. Power as an accidental of initial hierarchy gives itself in hands of that who can submit its will to absolute power of Destiny. The legitimacy of power is determined by initial hierarchy of the universe

  14. CAUSAL INFERENCE WITH A GRAPHICAL HIERARCHY OF INTERVENTIONS.

    Science.gov (United States)

    Shpitser, Ilya; Tchetgen, Eric Tchetgen

    2016-12-01

    Identifying causal parameters from observational data is fraught with subtleties due to the issues of selection bias and confounding. In addition, more complex questions of interest, such as effects of treatment on the treated and mediated effects may not always be identified even in data where treatment assignment is known and under investigator control, or may be identified under one causal model but not another. Increasingly complex effects of interest, coupled with a diversity of causal models in use resulted in a fragmented view of identification. This fragmentation makes it unnecessarily difficult to determine if a given parameter is identified (and in what model), and what assumptions must hold for this to be the case. This, in turn, complicates the development of estimation theory and sensitivity analysis procedures. In this paper, we give a unifying view of a large class of causal effects of interest, including novel effects not previously considered, in terms of a hierarchy of interventions, and show that identification theory for this large class reduces to an identification theory of random variables under interventions from this hierarchy. Moreover, we show that one type of intervention in the hierarchy is naturally associated with queries identified under the Finest Fully Randomized Causally Interpretable Structure Tree Graph (FFRCISTG) model of Robins (via the extended g-formula), and another is naturally associated with queries identified under the Non-Parametric Structural Equation Model with Independent Errors (NPSEM-IE) of Pearl, via a more general functional we call the edge g-formula. Our results motivate the study of estimation theory for the edge g-formula, since we show it arises both in mediation analysis, and in settings where treatment assignment has unobserved causes, such as models associated with Pearl's front-door criterion.

  15. Improving Maslow’s Hierarchy of Needs: New Approach to needs hierarchy

    OpenAIRE

    Babak Nemati

    2013-01-01

    In this article Maslow's hierarchy of needs is reviewed with two viewpoints: critical and supportive. We try to extract and classify the relevant subject related to the research content after studying and analysis of documents. Thus, because of their common characters, the needs that have been cited from some scientists could be gathered and make some new levels.The new Maslow's hierarchy of needs has been presented in this research and we added three levels EPISTEMOLOGY, LOG and EROS (Freedo...

  16. Dispersionless and multicomponent BKP hierarchies with quantum torus symmetries

    Science.gov (United States)

    Li, Chuanzhong

    2017-09-01

    In this article, we will construct the additional perturbative quantum torus symmetry of the dispersionless BKP hierarchy based on the W∞ infinite dimensional Lie symmetry. These results show that the complete quantum torus symmetry is broken from the BKP hierarchy to its dispersionless hierarchies. Further a series of additional flows of the multicomponent BKP hierarchy will be defined and these flows constitute an N-folds direct product of the positive half of the quantum torus symmetries.

  17. Structure of the hypothetical protein Ton1535 from Thermococcus onnurineus NA1 reveals unique structural properties by a left-handed helical turn in normal α-solenoid protein.

    Science.gov (United States)

    Jeong, Jae-Hee; Kim, Yi-Seul; Rojvirija, Catleya; Cha, Hyung Jin; Kim, Yeon-Gil; Ha, Sung Chul

    2014-06-01

    The crystal structure of Ton1535, a hypothetical protein from Thermococcus onnurineus NA1, was determined at 2.3 Å resolution. With two antiparallel α-helices in a helix-turn-helix motif as a repeating unit, Ton1535 consists of right-handed coiled N- and C-terminal regions that are stacked together using helix bundles containing a left-handed helical turn. One left-handed helical turn in the right-handed coiled structure produces two unique structural properties. One is the presence of separated concave grooves rather than one continuous concave groove, and the other is the contribution of α-helices on the convex surfaces of the N-terminal region to the extended surface of the concave groove of the C-terminal region and vice versa.

  18. Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus

    Directory of Open Access Journals (Sweden)

    Yehoshua Perl

    2008-01-01

    Full Text Available Gene terminologies are playing an increasingly important role in the ever-growing field of genomic research. While errors in large, complex terminologies are inevitable, gene terminologies are even more susceptible to them due to the rapid growth of genomic knowledge and the nature of its discovery. It is therefore very important to establish quality- assurance protocols for such genomic-knowledge repositories. Different kinds of terminologies oftentimes require auditing methodologies adapted to their particular structures. In light of this, an auditing methodology tailored to the characteristics of the NCI Thesaurus’s (NCIT’s Gene hierarchy is presented. The Gene hierarchy is of particular interest to the NCIT’s designers due to the primary role of genomics in current cancer research. This multiphase methodology focuses on detecting role-errors, such as missing roles or roles with incorrect or incomplete target structures, occurring within that hierarchy. The methodology is based on two kinds of abstraction networks, called taxonomies, that highlight the role distribution among concepts within the IS-A (subsumption hierarchy. These abstract views tend to highlight portions of the hierarchy having a higher concentration of errors. The errors found during an application of the methodology

  19. Detecting Role Errors in the Gene Hierarchy of the NCI Thesaurus

    Science.gov (United States)

    Min, Hua; Cohen, Barry; Halper, Michael; Oren, Marc; Perl, Yehoshua

    2008-01-01

    Gene terminologies are playing an increasingly important role in the ever-growing field of genomic research. While errors in large, complex terminologies are inevitable, gene terminologies are even more susceptible to them due to the rapid growth of genomic knowledge and the nature of its discovery. It is therefore very important to establish quality-assurance protocols for such genomic-knowledge repositories. Different kinds of terminologies oftentimes require auditing methodologies adapted to their particular structures. In light of this, an auditing methodology tailored to the characteristics of the NCI Thesaurus’s (NCIT’s) Gene hierarchy is presented. The Gene hierarchy is of particular interest to the NCIT’s designers due to the primary role of genomics in current cancer research. This multiphase methodology focuses on detecting role-errors, such as missing roles or roles with incorrect or incomplete target structures, occurring within that hierarchy. The methodology is based on two kinds of abstraction networks, called taxonomies, that highlight the role distribution among concepts within the IS-A (subsumption) hierarchy. These abstract views tend to highlight portions of the hierarchy having a higher concentration of errors. The errors found during an application of the methodology are reported. Hypotheses pertaining to the efficacy of our methodology are investigated. PMID:19221606

  20. Basic Studies of Learning Hierarchies in School Subjects. Final Report.

    Science.gov (United States)

    Gagne, Robert M.

    This study explores three areas of learning hierarchies: (1) the condition for learning in accordance with learning hierarchies; (2) the use of hierarchies in the diagnosis and learning of prerequisite intellectual skills; and (3) the conditions of learning and retention of principles. There were seven studies undertaken using elementary and…

  1. The multicomponent (2+1)-dimensional Glachette-Johnson (GJ) equation hierarchy and its super-integrable coupling system

    Institute of Scientific and Technical Information of China (English)

    Yu Fa-Jun; Zhang Hong-Qing

    2008-01-01

    This paper presents a set of multicomponent matrix Lie algebra,which is used to construct a new loop algebra (A)M.By using the Tu scheme,a Liouville integrable multicomponent equation hierarchy is generated,which possesses the Hamiltonian structure.As its reduction cases,the multicomponent (2+1)-dimensional Glaehette-Johnson (GJ) hierarchy is given.Finally,the super-integrable coupling system of multicomponent (2+1)-dimensional GJ hierarchy is established through enlarging the spectral problem.

  2. New Matrix Lie Algebra, a Powerful Tool for Constructing Multi-component C-KdV Equation Hierarchy

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    A set of new multi-component matrix Lie algebra is constructed, which is devoted to obtaining a new loop algebra A-2M. It follows that an isospectral problem is established. By making use of Tu scheme, a Liouville integrable multi-component hierarchy of soliton equations is generated, which possesses the multi-component Hamiltonian structures. As its reduction cases, the multi-component C-KdV hierarchy is given. Finally, the multi-component integrable coupling system of C-KdV hierarchy is presented through enlarging matrix spectral problem.

  3. The bounding-surfaces record of a barrier spit from Huangqihai Lake, North China: implications for coastal barrier boundary hierarchy

    Science.gov (United States)

    Shan, Xin; Yu, Xinghe; Clift, Peter D.; Wang, Tianyi; Tan, Chengpeng; Jin, Lina

    2016-09-01

    Ground-penetrating radar and trenching studies of a barrier spit on the north shore of Huangqihai Lake were made, that reveal important implications for the coastal washover barrier boundary hierarchy and interpretations of this depositional record. A four-fold hierarchy bounding-surface model, representing different levels of impact and genesis, is defined. Each level of the hierarchy is enclosed by a distinct kind of surface characterized by different ground-penetrating radar reflection features, sedimentary characteristics (color, grain size, sorting, rounding and sedimentary structures) and origin. We suggest that this hierarchical model can be applied to any coastal washover barrier deposits.

  4. Approximate Matching of Hierarchial Data

    DEFF Research Database (Denmark)

    Augsten, Nikolaus

    The goal of this thesis is to design, develop, and evaluate new methods for the approximate matching of hierarchical data represented as labeled trees. In approximate matching scenarios two items should be matched if they are similar. Computing the similarity between labeled trees is hard...... as in addition to the data values also the structure must be considered. A well-known measure for comparing trees is the tree edit distance. It is computationally expensive and leads to a prohibitively high run time. Our solution for the approximate matching of hierarchical data are pq-grams. The pq...... formally proof that the pq-gram index can be incrementally updated based on the log of edit operations without reconstructing intermediate tree versions. The incremental update is independent of the data size and scales to a large number of changes in the data. We introduce windowed pq...

  5. Heterarchies: Reconciling Networks and Hierarchies.

    Science.gov (United States)

    Cumming, Graeme S

    2016-08-01

    Social-ecological systems research suffers from a disconnect between hierarchical (top-down or bottom-up) and network (peer-to-peer) analyses. The concept of the heterarchy unifies these perspectives in a single framework. Here, I review the history and application of 'heterarchy' in neuroscience, ecology, archaeology, multiagent control systems, business and organisational studies, and politics. Recognising complex system architecture as a continuum along vertical and lateral axes ('flat versus hierarchical' and 'individual versus networked') suggests four basic types of heterarchy: reticulated, polycentric, pyramidal, and individualistic. Each has different implications for system functioning and resilience. Systems can also shift predictably and abruptly between architectures. Heterarchies suggest new ways of contextualising and generalising from case studies and new methods for analysing complex structure-function relations.

  6. Cumulative hierarchies and computability over universes of sets

    Directory of Open Access Journals (Sweden)

    Domenico Cantone

    2008-05-01

    Full Text Available Various metamathematical investigations, beginning with Fraenkel’s historical proof of the independence of the axiom of choice, called for suitable definitions of hierarchical universes of sets. This led to the discovery of such important cumulative structures as the one singled out by von Neumann (generally taken as the universe of all sets and Godel’s universe of the so-called constructibles. Variants of those are exploited occasionally in studies concerning the foundations of analysis (according to Abraham Robinson’s approach, or concerning non-well-founded sets. We hence offer a systematic presentation of these many structures, partly motivated by their relevance and pervasiveness in mathematics. As we report, numerous properties of hierarchy-related notions such as rank, have been verified with the assistance of the ÆtnaNova proof-checker.Through SETL and Maple implementations of procedures which effectively handle the Ackermann’s hereditarily finite sets, we illustrate a particularly significant case among those in which the entities which form a universe of sets can be algorithmically constructed and manipulated; hereby, the fruitful bearing on pure mathematics of cumulative set hierarchies ramifies into the realms of theoretical computer science and algorithmics.

  7. Nucleosomes, Linker DNA, and Linker Histone form a Unique Structural Motif that Directs the Higher-Order Folding and Compaction of Chromatin

    Science.gov (United States)

    Bednar, Jan; Horowitz, Rachel A.; Grigoryev, Sergei A.; Carruthers, Lenny M.; Hansen, Jeffrey C.; Koster, Abraham J.; Woodcock, Christopher L.

    1998-11-01

    The compaction level of arrays of nucleosomes may be understood in terms of the balance between the self-repulsion of DNA (principally linker DNA) and countering factors including the ionic strength and composition of the medium, the highly basic N termini of the core histones, and linker histones. However, the structural principles that come into play during the transition from a loose chain of nucleosomes to a compact 30-nm chromatin fiber have been difficult to establish, and the arrangement of nucleosomes and linker DNA in condensed chromatin fibers has never been fully resolved. Based on images of the solution conformation of native chromatin and fully defined chromatin arrays obtained by electron cryomicroscopy, we report a linker histone-dependent architectural motif beyond the level of the nucleosome core particle that takes the form of a stem-like organization of the entering and exiting linker DNA segments. DNA completes ≈ 1.7 turns on the histone octamer in the presence and absence of linker histone. When linker histone is present, the two linker DNA segments become juxtaposed ≈ 8 nm from the nucleosome center and remain apposed for 3-5 nm before diverging. We propose that this stem motif directs the arrangement of nucleosomes and linker DNA within the chromatin fiber, establishing a unique three-dimensional zigzag folding pattern that is conserved during compaction. Such an arrangement with peripherally arranged nucleosomes and internal linker DNA segments is fully consistent with observations in intact nuclei and also allows dramatic changes in compaction level to occur without a concomitant change in topology.

  8. A 2 + 1 non-isospectral integrable lattice hierarchy related to a generalized discrete second Painleve hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Gordoa, Pilar R. [Area de Matematica Aplicada, ESCET, Universidad Rey Juan Carlos, C/Tulipan s/n, 28933 Mostoles, Madrid (Spain); Pickering, Andrew [Area de Matematica Aplicada, ESCET, Universidad Rey Juan Carlos, C/Tulipan s/n, 28933 Mostoles, Madrid (Spain)]. E-mail: andrew.pickering@urjc.es; Zhu Zuonong [Department of Mathematics, Shanghai Jiao Tong University, Shanghai, 200030 (China); Departamento de Matematicas, Universidad de Salamanca, Plaza de la Merced 1, 37008 Salamanca (Spain)

    2006-08-15

    In this article, by considering a 2 + 1 dimensional discrete non-isospectral linear problem, a new 2 + 1 dimensional integrable lattice hierarchy is constructed. It is shown that a generalization of the discrete second Painleve hierarchy can be obtained as a reduction. Other reductions include new 1 + 1 dimensional integrable lattice hierarchies.

  9. Emergence of hierarchy in cost driven growth of spatial networks

    CERN Document Server

    Louf, Rémi; Barthelemy, Marc

    2013-01-01

    One of the most important features of spatial networks such as transportation networks, power grids, Internet, neural networks, is the existence of a cost associated with the length of links. Such a cost has a profound influence on the global structure of these networks which usually display a hierarchical spatial organization. The link between local constraints and large-scale structure is however not elucidated and we introduce here a generic model for the growth of spatial networks based on the general concept of cost benefit analysis. This model depends essentially on one single scale and produces a family of networks which range from the star-graph to the minimum spanning tree and which are characterised by a continuously varying exponent. We show that spatial hierarchy emerges naturally, with structures composed of various hubs controlling geographically separated service areas, and appears as a large-scale consequence of local cost-benefit considerations. Our model thus provides the first building bloc...

  10. Neural basis of social status hierarchy across species.

    Science.gov (United States)

    Chiao, Joan Y

    2010-12-01

    Social status hierarchy is a ubiquitous principle of social organization across the animal kingdom. Recent findings in social neuroscience reveal distinct neural networks associated with the recognition and experience of social hierarchy in humans, as well as modulation of these networks by personality and culture. Additionally, allelic variation in the serotonin transporter gene is associated with prevalence of social hierarchy across species and cultures, suggesting the importance of the study of genetic factors underlying social hierarchy. Future studies are needed to determine how genetic and environmental factors shape neural systems involved in the production and maintenance of social hierarchy across ontogeny and phylogeny. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. Mass Hierarchy of Collisional Energy Loss

    CERN Document Server

    Kolevatov, Rodion

    2008-01-01

    Collisional parton energy loss is revisited within a simple model assuming incoherent elastic scattering of on-shell projectile partons on partonic constituents of the QGP with HTL screening. The thermal motion of plasma particles is carefully taken into account. Results on $dE/dx$ are found to be consistent with other authors. There is a significant discrepancy in the energy loss pattern for the cases with thermal motion on and off, which illustrates the importance of taking the kinematics into account exactly. The dependence on the mass of the partons forming the plasma is included in the calculations and its influence on the collisional energy loss is studied. The mass hierarchy of collisional energy loss is found to have a strong dependence on the mass introduced for plasma particles. Due to difference in the mass hierarchy with radiative energy loss, the collisional one when included increases the relative suppression of heavy quarks compared to light quarks.

  12. Feminist Praxis, Critical Theory and Informal Hierarchies

    Directory of Open Access Journals (Sweden)

    Eva Giraud

    2015-05-01

    Full Text Available This article draws on my experiences teaching across two undergraduate media modules in a UK research-intensive institution to explore tactics for combatting both institutional and informal hierarchies within university teaching contexts. Building on Sara Motta’s (2012 exploration of implementing critical pedagogic principles at postgraduate level in an elite university context, I discuss additional tactics for combatting these hierarchies in undergraduate settings, which were developed by transferring insights derived from informal workshops led by the University of Nottingham’s Feminism and Teaching network into the classroom. This discussion is framed in relation to the concepts of “cyborg pedagogies” and “political semiotics of articulation,” derived from the work of Donna Haraway, in order to theorize how these tactics can engender productive relationships between radical pedagogies and critical theory.

  13. Homology and the hierarchy of biological systems.

    Science.gov (United States)

    Sommer, Ralf J

    2008-07-01

    Homology is the similarity between organisms due to common ancestry. Introduced by Richard Owen in 1843 in a paper entitled "Lectures on comparative anatomy and physiology of the invertebrate animals", the concept of homology predates Darwin's "Origin of Species" and has been very influential throughout the history of evolutionary biology. Although homology is the central concept of all comparative biology and provides a logical basis for it, the definition of the term and the criteria of its application remain controversial. Here, I will discuss homology in the context of the hierarchy of biological organization. I will provide insights gained from an exemplary case study in evolutionary developmental biology that indicates the uncoupling of homology at different levels of biological organization. I argue that continuity and hierarchy are separate but equally important issues of homology. (c) 2008 Wiley Periodicals, Inc.

  14. Hamiltonian hierarchy and the Hulthen potential

    CERN Document Server

    Gönül, B

    2000-01-01

    We deal with the Hamiltonian hierarchy problem of the Hulth\\'{e}n potential within the frame of the supersymmetric quantum mechanics and find that the associated superymmetric partner potentials simulate the effect of the centrifugal barrier. Incorporating the supersymmetric solutions and using the first-order perturbation theory we obtain an expression for the energy levels of theHulth\\'{e}n potential which gives satisfactory values for the non-zero angular momentum states.

  15. INFORMATION GATHERING, DELEGATED CONTRACTING AND CORPORATE HIERARCHIES

    OpenAIRE

    Chongwoo Choe; In-Uck Park

    2008-01-01

    In a typical corporate hierarchy, the manager is delegated the authority to make strategic decisions, and to contract with other employees. We study when such delegation can be optimal. In centralization, the owner retains the authority, which fails to motivate the manager to acquire valuable information, leading to suboptimal decisions and inefficient incentive provision to the worker. Beneficial delegation should necessarily motivate the manager to acquire information, which is possible onl...

  16. Using the Attribute Hierarchy Method to Make Diagnostic Inferences about Examinees' Knowledge and Skills in Mathematics: An Operational Implementation of Cognitive Diagnostic Assessment

    Science.gov (United States)

    Gierl, Mark J.; Alves, Cecilia; Majeau, Renate Taylor

    2010-01-01

    The purpose of this study is to apply the attribute hierarchy method in an operational diagnostic mathematics program at Grades 3 and 6 to promote cognitive inferences about students' problem-solving skills. The attribute hierarchy method is a psychometric procedure for classifying examinees' test item responses into a set of structured attribute…

  17. Comparing the hierarchy of keywords in on-line news portals

    CERN Document Server

    Tibély, Gergely; Pollner, Péter; Palla, Gergely

    2016-01-01

    The tagging of on-line content with informative keywords is a widespread phenomenon from scientific article repositories through blogs to on-line news portals. In most of the cases, the tags on a given item are free words chosen by the authors independently. Therefore, relations among keywords in a collection of news items is unknown. However, in most cases the topics and concepts described by these keywords are forming a latent hierarchy, with the more general topics and categories at the top, and more specialised ones at the bottom. Here we apply a recent, cooccurrence-based tag hierarchy extraction method to sets of keywords obtained from four different on-line news portals. The resulting hierarchies show substantial differences not just in the topics rendered as important (being at the top of the hierarchy) or of less interest (categorised low in the hierarchy), but also in the underlying network structure. This reveals discrepancies between the plausible keyword association frameworks in the studied news...

  18. Who's on First? Investigating the referential hierarchy in simple native ASL narratives.

    Science.gov (United States)

    Frederiksen, Anne Therese; Mayberry, Rachel I

    2016-09-01

    Discussions of reference tracking in spoken languages often invoke some version of a referential hierarchy. In this paper, we asked whether this hierarchy applies equally well to reference tracking in a visual language, American Sign Language, or whether modality differences influence its structure. Expanding the results of previous studies, this study looked at ASL referential devices beyond nouns, pronouns, and zero anaphora. We elicited four simple narratives from eight native ASL signers, and examined how the signers tracked reference throughout their stories. We found that ASL signers follow general principles of the referential hierarchy proposed for spoken languages by using nouns for referent introductions, and zero anaphora for referent maintenance. However, we also found significant differences such as the absence of pronouns in the narratives, despite their existence in ASL, and differential use of verbal and constructed action zero anaphora. Moreover, we found that native signers' use of classifiers varied with discourse status in a way that deviated from our expectations derived from the referential hierarchy for spoken languages. On this basis, we propose a tentative hierarchy of referential expressions for ASL that incorporates modality specific referential devices.

  19. Unique Path Partitions

    DEFF Research Database (Denmark)

    Bessenrodt, Christine; Olsson, Jørn Børling; Sellers, James A.

    2013-01-01

    We give a complete classification of the unique path partitions and study congruence properties of the function which enumerates such partitions.......We give a complete classification of the unique path partitions and study congruence properties of the function which enumerates such partitions....

  20. DECISION MAKING-THE ANALYTIC HIERARCHY AND NETWORK PROCESSES(AHP/ANP)

    Institute of Scientific and Technical Information of China (English)

    Thomas L.SAATY

    2004-01-01

    This is the first part of an introduction to multicriteria decision making using the Analytic Hierarchy Process (AHP) and its generalization, the Analytic Network Process (ANP). The discussion involves individual and group decisions both with the independence of the criteria from the alternatives as in the AHP and also with dependence and feedback in the entire decision structure as in the ANP. This part explains the Analytic Hierarchy Process, with examples, and presents in some detail the mathematical foundations. An exposition of the Analytic Network Process and its applications will appear in later issues of this journal.

  1. Research on Marketing Channel of Mobile Manufacturer Based on Analytic Hierarchy Process

    Institute of Scientific and Technical Information of China (English)

    XIONG Hui; LI Shi-ming; LAN Yong

    2006-01-01

    Research on "marketing channel" of mobile attracts much attention in these years,but there're only few articles referring to how to optimize the disposition of channel resources for mobile manufacturers. Based on a typically multiplex marketing channel system of mobile manufacturer, the analytic hierarchy process (AHP) structure model is established. Through the judgment matrix, simple and total hierarchy arrangement, consistent test, this paper gets the weight of each kind of marketing channel of mobile manufacturer. It provides the practical reference value for mobile manufacturers to distribute resources of marketing channels.

  2. Lax Triad Approach to Symmetries of Scalar Modified Kadomtsev–Petviashvili Hierarchy

    Science.gov (United States)

    Deng, Xiao; Chen, Kui; Zhang, Da-Jun

    2017-02-01

    By means of Lax triads we reconstruct isospectral and nonisospectral scalar modified Kadomtsev–Petviashvili (mKP) hierarchies. In this approach the argument y is treated as an independent variable which is independent of time parameters \\{{t}1,{t}2,\\ldots \\}. Consequently, the isospectral and nonisospectral scalar mKP flows can have clear zero curvature representations, which enables us to handle investigation of symmetries of the scalar isospectral mKP hierarchy as freely as for (1+1)-dimensional systems. As a result, we obtain Lie algebraic structures of the scalar mKP flows and construct symmetries for the scalar isospectral mKP hierarchy. Supported by the National Natural Science Foundation of China under Grant No. 11371241

  3. Dual Hierarchies of a Multi-Component Camassa-Holm System

    Science.gov (United States)

    Li, Hong-Min; Li, Yu-Qi; Chen, Yong

    2015-10-01

    In this paper, we derive the bi-Hamiltonian structure of a multi-component Camassa-Holm system, which associates with the multi-component AKNS hierarchy and multi-component KN hierarchy via the tri-Hamiltonian duality method. Furthermore, the spectral problems of the dual hierarchies may be obtained. Supported by the National Natural Science Foundation of China under Grant Nos. 11275072 and 11375090, Research Fund for the Doctoral Program of Higher Education of China under No. 20120076110024, the Innovative Research Team Program of the National Natural Science Foundation of China under Grant No. 61321064, Shanghai Knowledge Service Platform for Trustworthy Internet of Things under Grant No. ZF1213, Talent Fund and K.C. Wong Magna Fund in Ningbo University

  4. Comparative Analysis between Fuzzy and Traditional Analytical Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Mulubrhan Freselam

    2014-07-01

    Full Text Available Analytic Hierarchy Process (AHP is one of the techniques commonly used for prioritizing different alternatives, by using complex criteria. In real applications, conventional AHP assumes the expert judgment as it is exact and use crisp number leading to inconsideration of the uncertainty that came from linguistic variable. Fuzzy logic deals with situations which are vague or unwell defined and gives a quantify value. In this study a comparison is made between traditional AHP and fuzzy AHP by taking a case of selecting an effective oil refinery. The selection is conducted using system effectiveness as a criterion. The two approaches have been compared on the same hierarchy structure and criteria set and the result show that in both case dual drum scheme (DDS has the highest priority but different value that is 0.51 and 0.36 for AHP and FAHP respectively which shows that if the expert opinion is certain AHP should be used if not FAHP should be preferred

  5. Hierarchy, causation and explanation: ubiquity, locality and pluralism.

    Science.gov (United States)

    Love, Alan C

    2012-02-06

    The ubiquity of top-down causal explanations within and across the sciences is prima facie evidence for the existence of top-down causation. Much debate has been focused on whether top-down causation is coherent or in conflict with reductionism. Less attention has been given to the question of whether these representations of hierarchical relations pick out a single, common hierarchy. A negative answer to this question undermines a commonplace view that the world is divided into stratified 'levels' of organization and suggests that attributions of causal responsibility in different hierarchical representations may not have a meaningful basis for comparison. Representations used in top-down and bottom-up explanations are primarily 'local' and tied to distinct domains of science, illustrated here by protein structure and folding. This locality suggests that no single metaphysical account of hierarchy for causal relations to obtain within emerges from the epistemology of scientific explanation. Instead, a pluralist perspective is recommended-many different kinds of top-down causation (explanation) can exist alongside many different kinds of bottom-up causation (explanation). Pluralism makes plausible why different senses of top-down causation can be coherent and not in conflict with reductionism, thereby illustrating a productive interface between philosophical analysis and scientific inquiry.

  6. On spectrum of ILW hierarchy in conformal field theory II: coset CFT’s

    Energy Technology Data Exchange (ETDEWEB)

    Alfimov, M.N. [LPT, Ecole Normale Superieure, 75005 Paris (France); Insitut de Physique Theorique, CEA Saclay, 91191 Gif-sur-Yvette Cedex (France); P.N. Lebedev Physical Institute, 119991 Moscow (Russian Federation); Moscow Institute of Physics and Technology, 141700 Dolgoprudny (Russian Federation); Litvinov, A.V. [Landau Institute for Theoretical Physics, 142432 Chernogolovka (Russian Federation); NHETC, Department of Physics and Astronomy, Rutgers University, Piscataway, NJ 08855-0849 (United States)

    2015-02-24

    We study integrable structure of the coset conformal field theory and define the system of Integrals of Motion which depends on external parameters. This system can be viewed as a quantization of the ILW type hierarchy. We propose a set of Bethe anzatz equations for its spectrum.

  7. The Implications of A. H. Maslow's "Hierarchy of Needs" Theory for Adult Education.

    Science.gov (United States)

    Warren, Earle Theodore

    The Maslow Hierarchy of Needs was reviewed and implications were sought for adult education theory, program planning and operation, promotional activities, and program evaluation. Maslow's work suggested self-actualization as an ultimate goal, meaning that adult education programs should be structured to foster both the acquisition of facts,…

  8. The Use of the Analytic Hierarchy Process to Aid Decision Making in Acquired Equinovarus Deformity

    NARCIS (Netherlands)

    Til, van J.A.; Renzenbrink, G.J.; Dolan, J.G.; IJzerman, M.J.

    2008-01-01

    Objective: To increase the transparency of decision making about treatment in patients with equinovarus deformity poststroke. - Design: The analytic hierarchy process (AHP) was used as a structured methodology to study the subjective rationale behind choice of treatment. - Setting: An 8-hour meeting

  9. Isolating causal pathways between flow and fish in the regulated river hierarchy

    Science.gov (United States)

    Ryan McManamay; Donald J. Orth; Charles A. Dolloff; David C. Mathews

    2015-01-01

    Unregulated river systems are organized in a hierarchy in which large scale factors (i.e. landscape and segment scales) influence local habitats (i.e. reach, meso- and microhabitat scales), and both differentially exert selective pressures on biota. Dams, however, create discontinua in these processes and change the hierarchical structure. We examined the relative...

  10. Nanostructural hierarchy increases the strength of aluminium alloys.

    Science.gov (United States)

    Liddicoat, Peter V; Liao, Xiao-Zhou; Zhao, Yonghao; Zhu, Yuntian; Murashkin, Maxim Y; Lavernia, Enrique J; Valiev, Ruslan Z; Ringer, Simon P

    2010-09-07

    Increasing the strength of metallic alloys while maintaining formability is an interesting challenge for enabling new generations of lightweight structures and technologies. In this paper, we engineer aluminium alloys to contain a hierarchy of nanostructures and possess mechanical properties that expand known performance boundaries-an aerospace-grade 7075 alloy exhibits a yield strength and uniform elongation approaching 1 GPa and 5%, respectively. The nanostructural architecture was observed using novel high-resolution microscopy techniques and comprises a solid solution, free of precipitation, featuring (i) a high density of dislocations, (ii) subnanometre intragranular solute clusters, (iii) two geometries of nanometre-scale intergranular solute structures and (iv) grain sizes tens of nanometres in diameter. Our results demonstrate that this novel architecture offers a design pathway towards a new generation of super-strong materials with new regimes of property-performance space.

  11. Recognition and stabilization of a unique CPRI--structural motif in cucurbitaceae family trypsin inhibitor peptides: molecular dynamics based homology modeling using the X-ray structure of MCTI-II.

    Science.gov (United States)

    Chakraborty, S; Haldar, U; Bera, A K; Pal, A K; Bhattacharya, S; Ghosh, S; Mukhopadhyay, B P; Banerjee, A

    2001-02-01

    The high resolution crystallographic structure of MCTI-II complexed with beta trypsin (PDB entry 1MCT) was used to model the corresponding structures of the six inhibitor peptides belonging to Cucurbitaceae family (MCTI-I, LA-1, LA-2, CMTI-I, CMTI-III, CMTI-IV). Two model inhibitors, LA-1 and LA-2 were refined by molecular dynamics to estimate the average solution structure. The difference accessible surface area (DASA) study of the inhibitors with and without trypsin revealed the Arginine and other residues of the inhibitors which bind to trypsin. The hydration dynamics study of LA1 and LA2 also confirm the suitability of water molecules at the active Arg site. Moreover, the presence of a unique 3D-structural motif comprises with the four CPRI residues from the amino terminal is thought to be conserved in all the six studied inhibitors, which seems essential for the directional fixation for proper complexation of the Arg (5) residue towards the trypsin S1-binding pocket. The role of the disulphide linkage in the geometrical stabilization of CPRI (Cysteine, Proline, Arginine, Isoleucine) motif has also been envisaged from the comparative higher intra molecular Cys (3) -Cys (20) disulphide dihedral energies.

  12. Hierarchy, Dominance, and Deliberation: Egalitarian Values Require Mental Effort.

    Science.gov (United States)

    Van Berkel, Laura; Crandall, Christian S; Eidelman, Scott; Blanchar, John C

    2015-09-01

    Hierarchy and dominance are ubiquitous. Because social hierarchy is early learned and highly rehearsed, the value of hierarchy enjoys relative ease over competing egalitarian values. In six studies, we interfere with deliberate thinking and measure endorsement of hierarchy and egalitarianism. In Study 1, bar patrons' blood alcohol content was correlated with hierarchy preference. In Study 2, cognitive load increased the authority/hierarchy moral foundation. In Study 3, low-effort thought instructions increased hierarchy endorsement and reduced equality endorsement. In Study 4, ego depletion increased hierarchy endorsement and caused a trend toward reduced equality endorsement. In Study 5, low-effort thought instructions increased endorsement of hierarchical attitudes among those with a sense of low personal power. In Study 6, participants' thinking quickly allocated more resources to high-status groups. Across five operationalizations of impaired deliberative thought, hierarchy endorsement increased and egalitarianism receded. These data suggest hierarchy may persist in part because it has a psychological advantage. © 2015 by the Society for Personality and Social Psychology, Inc.

  13. Evidence of a dominance hierarchy in captive Caribbean flamingos and its relation to pair bonding and physiological measures of health.

    Science.gov (United States)

    Royer, Erica A; Anderson, Matthew J

    2014-06-01

    Caribbean flamingo social structure, how pair bonds affect the structure of the flock, and how social stress affects health measured by heterophil to lymphocyte ratios (H/L) were investigated at the Philadelphia Zoo. It was hypothesized that a hierarchy may become apparent by analyzing agonistic interactions and that paired individuals would share similar places within the hierarchy. Furthermore, it was hypothesized that a negative relationship between H/L ratio and dominance would exist. Forty observations were conducted and in 70% of interactions instigating bird(s) won the encounter, suggesting either some advantage for instigating birds or a prior expectation of an encounter's outcome based upon an understanding of the flock's hierarchy. The flock possessed a semi-linear hierarchy (in terms of wins/losses) and birds with higher pair-bond strengths maintained dominant positions, suggesting that pair-bonding may help individuals become more successful in agonistic encounters. Birds who won more often had higher lymphocytes percentages and analyses suggested a trend indicating dominant birds may be less stressed. A semi-linear hierarchy was also found in terms of initiation/being targeted, and a bird's rank on the dominance (wins/losses) and initiate/target hierarchies were positively correlated, suggesting that subdominant birds were targeted by dominant birds more frequently than vice versa. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Memory-Scalable GPU Spatial Hierarchy Construction.

    Science.gov (United States)

    Qiming Hou; Xin Sun; Kun Zhou; Lauterbach, C; Manocha, D

    2011-04-01

    Recent GPU algorithms for constructing spatial hierarchies have achieved promising performance for moderately complex models by using the breadth-first search (BFS) construction order. While being able to exploit the massive parallelism on the GPU, the BFS order also consumes excessive GPU memory, which becomes a serious issue for interactive applications involving very complex models with more than a few million triangles. In this paper, we propose to use the partial breadth-first search (PBFS) construction order to control memory consumption while maximizing performance. We apply the PBFS order to two hierarchy construction algorithms. The first algorithm is for kd-trees that automatically balances between the level of parallelism and intermediate memory usage. With PBFS, peak memory consumption during construction can be efficiently controlled without costly CPU-GPU data transfer. We also develop memory allocation strategies to effectively limit memory fragmentation. The resulting algorithm scales well with GPU memory and constructs kd-trees of models with millions of triangles at interactive rates on GPUs with 1 GB memory. Compared with existing algorithms, our algorithm is an order of magnitude more scalable for a given GPU memory bound. The second algorithm is for out-of-core bounding volume hierarchy (BVH) construction for very large scenes based on the PBFS construction order. At each iteration, all constructed nodes are dumped to the CPU memory, and the GPU memory is freed for the next iteration's use. In this way, the algorithm is able to build trees that are too large to be stored in the GPU memory. Experiments show that our algorithm can construct BVHs for scenes with up to 20 M triangles, several times larger than previous GPU algorithms.

  15. Vanishing point: Scale independence in geomorphological hierarchies

    Science.gov (United States)

    Phillips, Jonathan D.

    2016-08-01

    Scale linkage problems in geosciences are often associated with a hierarchy of components. Both dynamical systems perspectives and intuition suggest that processes or relationships operating at fundamentally different scales are independent with respect to influences on system dynamics. But how far apart is "fundamentally different"-that is, what is the "vanishing point" at which scales are no longer interdependent? And how do we reconcile that with the idea (again, supported by both theory and intuition) that we can work our way along scale hierarchies from microscale to planetary (and vice-versa)? Graph and network theory are employed here to address these questions. Analysis of two archetypal hierarchical networks shows low algebraic connectivity, indicating low levels of inferential synchronization. This explains the apparent paradox between scale independence and hierarchical linkages. Incorporating more hierarchical levels results in an increase in complexity or entropy of the network as a whole, but at a nonlinear rate. Complexity increases as a power α of the number of levels in the hierarchy, with α < 1 and usually ≤ 0.6. However, algebraic connectivity decreases at a more rapid rate. Thus, the ability to infer one part of the hierarchical network from other level decays rapidly as more levels are added. Relatedness among system components decreases with differences in scale or resolution, analogous to distance decay in the spatial domain. These findings suggest a strategy of identifying and focusing on the most important or interesting scale levels, rather than attempting to identify the smallest or largest scale levels and work top-down or bottom-up from there. Examples are given from soil geomorphology and karst flow networks.

  16. Fossil insects may provide unique information on structures and disturbances in past forest ecosystems - examples from Holocene studies in southern Sweden

    Science.gov (United States)

    Lemdahl, Geoffrey; Gustavsson, Gunnar; Olsson, Fredrik; Gaillard, Marie-José

    2010-05-01

    Insects are complex organisms that play an important role in all types of forest ecosystems. Insect remains are often abundant in waterlogged sediments and peat, and the majority of the fossils may be identified to species level, thus contributing with specific information. The occurrence of species feeding or confined to one or a few species of herbaceous plants, shrubs and trees may confirm or improve/refine the interpretations based on pollen and plant macrofossil analyses. Many insects, particularly ground living animals, select open, sun exposed habitats or closed shaded areas. Such indicators are valuable for reconstructions of forest/landscape openness. However, unique information can be provided by fossil insect assemblages. Insect studies carried out at two natural sites in southern Sweden with complete Holocene peat stratigraphies (Olsson and Lemdahl 2009) and a number of sites covering parts of the Holocene (e.g. Gaillard and Lemdahl 1994, Gustavsson et al. 2009) provide strong evidence on changes in forest structure and the occurrence and nature of disturbances. Studies in Britain have yielded similar results (e.g. Whitehouse 2006). Saproxylic beetles indicate the presence of dead wood, which clearly was a more prominent component in ancient woodlands than in present forests, and beetles confined to wood mould suggest the presence of large hollow trees. Finds of pyrophilic species, of which some are very rare in European woodlands today, together with layers of charcoal, suggest that fire was a major disturbance factor during most of the Holocene in southern Sweden. Whereas macroscopic charcoal fragments indicate local fires, the presence of pyrophilic insects is an indication of continuous fire activity at the regional spatial scale. Remains of dung beetles indicate extensive grazing by megaherbivores during early Holocene, and more intensive grazing during late Holocene, whereas such indicators are absent from mid Holocene records, which correlates

  17. White Paper: Measuring the Neutrino Mass Hierarchy

    CERN Document Server

    Cahn, R N; Freedman, S J; Haxton, W C; Kadel, R W; Kolomensky, Yu G; Luk, K B; McDonald, P; Gann, G D Orebi; Poon, A W P

    2013-01-01

    This white paper is a condensation of a report by a committee appointed jointly by the Nuclear Science and Physics Divisions at Lawrence Berkeley National Laboratory (LBNL). The goal of this study was to identify the most promising technique(s) for resolving the neutrino mass hierarchy. For the most part, we have relied on calculations and simulations presented by the proponents of the various experiments. We have included evaluations of the opportunities and challenges for these experiments based on what is available already in the literature.

  18. Mixed superposition rules and the Riccati hierarchy

    Science.gov (United States)

    Grabowski, Janusz; de Lucas, Javier

    Mixed superposition rules, i.e., functions describing the general solution of a system of first-order differential equations in terms of a generic family of particular solutions of first-order systems and some constants, are studied. The main achievement is a generalization of the celebrated Lie-Scheffers Theorem, characterizing systems admitting a mixed superposition rule. This somehow unexpected result says that such systems are exactly Lie systems, i.e., they admit a standard superposition rule. This provides a new and powerful tool for finding Lie systems, which is applied here to studying the Riccati hierarchy and to retrieving some known results in a more efficient and simpler way.

  19. Mixed superposition rules and the Riccati hierarchy

    CERN Document Server

    Grabowski, Janusz

    2012-01-01

    Mixed superposition rules, i.e., functions describing the general solution of a system of first-order differential equations in terms of a generic family of particular solutions of first-order systems and some constants, are studied. The main achievement is a generalization of the celebrated Lie-Scheffers Theorem, characterizing systems admitting a mixed superposition rule. This somehow unexpected result says that such systems are exactly Lie systems, i.e., they admit a standard superposition rule. This provides a new and powerful tool for finding Lie systems, which is applied here to studying the Riccati hierarchy and to retrieving some known results in a more efficient and simpler way.

  20. The Hierarchy Solution to the LHC Inverse Problem

    CERN Document Server

    Gainer, James S; Park, Myeonghun

    2015-01-01

    Supersymmetric (SUSY) models, even those described by relatively few parameters, generically allow many possible SUSY particle (sparticle) mass hierarchies. As the sparticle mass hierarchy determines, to a great extent, the collider phenomenology of a model, the enumeration of these hierarchies is of the utmost importance. We therefore provide a readily generalizable procedure for determining the number of sparticle mass hierarchies in a given SUSY model. As an application, we analyze the gravity-mediated SUSY breaking scenario with various combinations of GUT-scale boundary conditions involving different levels of universality among the gaugino and scalar masses. For each of the eight considered models, we provide the complete list of forbidden hierarchies in a compact form. Our main result is that the complete (typically rather large) set of forbidden hierarchies among the eight sparticles considered in this analysis can be fully specified by just a few forbidden relations involving much smaller subsets of ...

  1. The hierarchy solution to the LHC inverse problem

    Science.gov (United States)

    Gainer, James S.; Matchev, Konstantin T.; Park, Myeonghun

    2015-06-01

    Supersymmetric (SUSY) models, even those described by relatively few parameters, generically allow many possible SUSY particle (sparticle) mass hierarchies. As the sparticle mass hierarchy determines, to a great extent, the collider phenomenology of a model, the enumeration of these hierarchies is of the utmost importance. We therefore provide a readily generalizable procedure for determining the number of sparticle mass hierarchies in a given SUSY model. As an application, we analyze the gravity-mediated SUSY breaking scenario with various combinations of GUT-scale boundary conditions involving different levels of universality among the gaugino and scalar masses. For each of the eight considered models, we provide the complete list of forbidden hierarchies in a compact form. Our main result is that the complete (typically rather large) set of forbidden hierarchies among the eight sparticles considered in this analysis can be fully specified by just a few forbidden relations involving much smaller subsets of sparticles.

  2. Neuroanatomical Markers of Social Hierarchy Recognition in Humans: A Combined ERP/MRI Study.

    Science.gov (United States)

    Santamaría-García, Hernando; Burgaleta, Miguel; Sebastián-Gallés, Nuria

    2015-07-29

    Social hierarchy is an ubiquitous principle of social organization across animal species. Although some progress has been made in our understanding of how humans infer hierarchical identity, the neuroanatomical basis for perceiving key social dimensions of others remains unexplored. Here, we combined event-related potentials and structural MRI to reveal the neuroanatomical substrates of early status recognition. We designed a covertly simulated hierarchical setting in which participants performed a task either with a superior or with an inferior player. Participants showed higher amplitude in the N170 component when presented with a picture of a superior player compared with an inferior player. Crucially, the magnitude of this effect correlated with brain morphology of the posterior cingulate cortex, superior temporal gyrus, insula, fusiform gyrus, and caudate nucleus. We conclude that early recognition of social hierarchies relies on the structural properties of a network involved in the automatic recognition of social identity. Humans can perceive social hierarchies very rapidly, an ability that is key for social interactions. However, some individuals are more sensitive to hierarchical information than others. Currently, it is unknown how brain structure supports such fast-paced processes of social hierarchy perception and their individual differences. Here, we addressed this issue for the first time by combining the high temporal resolution of event-related potentials (ERPs) and the high spatial resolution of structural MRI. This methodological approach allowed us to unveil a novel association between ERP neuromarkers of social hierarchy perception and the morphology of several cortical and subcortical brain regions typically assumed to play a role in automatic processes of social cognition. Our results are a step forward in our understanding of the human social brain. Copyright © 2015 the authors 0270-6474/15/3510843-08$15.00/0.

  3. The Impact of Formal Hierarchies on Enterprise Social Networking Behavior

    DEFF Research Database (Denmark)

    Behrendt, Sebastian; Klier, Julia; Klier, Mathias

    2015-01-01

    With more and more companies using enterprise social networks (ESN) for employee communication and collaboration, the influence of ESN on organizational hierarchies has been subject of countless discussions in practice-oriented media and first academic studies. Conversely, the question whether...... impact on social networking behavior. By applying means of social network analysis and supported by statements from interviews, we illustrate how deeply formal hierarchy impacts the three examined types of relationships. Our results motivate academics to further study the interrelation between hierarchy...

  4. Evaluating supplier quality performance using fuzzy analytical hierarchy process

    Science.gov (United States)

    Ahmad, Nazihah; Kasim, Maznah Mat; Rajoo, Shanmugam Sundram Kalimuthu

    2014-12-01

    Evaluating supplier quality performance is vital in ensuring continuous supply chain improvement, reducing the operational costs and risks towards meeting customer's expectation. This paper aims to illustrate an application of Fuzzy Analytical Hierarchy Process to prioritize the evaluation criteria in a context of automotive manufacturing in Malaysia. Five main criteria were identified which were quality, cost, delivery, customer serviceand technology support. These criteria had been arranged into hierarchical structure and evaluated by an expert. The relative importance of each criteria was determined by using linguistic variables which were represented as triangular fuzzy numbers. The Center of Gravity defuzzification method was used to convert the fuzzy evaluations into their corresponding crisps values. Such fuzzy evaluation can be used as a systematic tool to overcome the uncertainty evaluation of suppliers' performance which usually associated with human being subjective judgments.

  5. The constrained KP hierarchy and the generalised Miura transformation

    CERN Document Server

    Mas, J; Mas, Javier; Ramos, Eduardo

    1995-01-01

    Recently much attention has been paid to the restriction of KP to the submanifold of operators which can be represented as a ratio of two purely differential operators L=AB^{-1}. Whereas most of the aspects concerning this reduced hierarchy, like the Lax flows and the Hamiltonians, are by now well understood, there still lacks a clear and conclusive statement about the associated Poisson structure. We fill this gap by placing the problem in a more general framework and then showing how the required result follows from an interesting property of the second Gelfand-Dickey brackets under multiplication and inversion of Lax operators. As a byproduct we give an elegant and simple proof of the generalised Kupershmidt-Wilson theorem.

  6. Hierarchy-Based Team Software Process Simulation Model

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    According to the characteristic of Team Software Process (TSP), it adopts a hierarchy-based model combined discrete event model with system dynamics model. This model represents TSP as form of two levels, the inner level embodies the continuity of the software process, the outer embodies the software development process by phases, and the structure and principle of the model is explained in detail, then formalization description of the model is offered. At last, an example is presented to demonstrate the simulation process and result. This model can simulate team software process from various angles, supervise and predict the software process. Also it can make the management of software development become more scientific and improve the quality of software.

  7. Aplikasi Analytical Hierarchy Process (AHP pada Pemilihan Software Manajemen Proyek

    Directory of Open Access Journals (Sweden)

    Siti Komsiyah

    2014-12-01

    Full Text Available The problem with many alternative decisions in the areas of management and administration commonly referred to as multi-attribute decision problems. For example, the decision problem with many variables so that the target decision can not always be determined easily. Well-known method of approach, to overcome this kind of problem is called the Analytical Hierarchy Process (AHP. AHP technique is given by arranging alternative levels of decision, so as to provide a structured quantitative description. Application of multi-attribute types of problems such as problems in the selection of software, car, project proposal, the university, the best employees, and so forth. In this paper, the approach developed using the AHP in software selection project management.

  8. The Spontaneous Origin of New Levels in a Scalar Hierarchy

    Directory of Open Access Journals (Sweden)

    Stanley N. Salthe

    2004-06-01

    Full Text Available Abstract: Given a background of universal thermodynamic disequilibrium, I suggest that the interpolation of new levels in a material scale hierarchy is favored when the entropy production of a local region would be increased by such structural complexification. This would involve the separation by order of magnitude of the average dynamical rate of the new level compared to those of the resulting contiguous levels from which it became disentangled, thereby facilitating laminar flows. Here the Second Law of thermodynamics is understood as a final cause, which can be expressed in this creative way when the surrounding superstructure has a form allowing it to mediate this change (by, e.g., focusing kinetics, etc., and given, as well, sufficiently differentiated local energy gradients to materially support the increased local dissipation.

  9. The Impact of Formal Hierarchies on Enterprise Social Networking Behavior

    DEFF Research Database (Denmark)

    Behrendt, Sebastian; Klier, Julia; Klier, Mathias;

    2015-01-01

    and how formal organizational hierarchies influence ESN usage behavior has not yet been addressed. Drawing on a rich data set comprising 2.5 years of relationship building via direct messages, confirmed contact requests, and group messages, we are able to show that formal hierarchies have an important...... impact on social networking behavior. By applying means of social network analysis and supported by statements from interviews, we illustrate how deeply formal hierarchy impacts the three examined types of relationships. Our results motivate academics to further study the interrelation between hierarchy...

  10. Correlating Dimensions of Inheritance Hierarchy with Complexity & Reuse

    Directory of Open Access Journals (Sweden)

    Nasib S. Gill

    2011-09-01

    Full Text Available Inheritance is the vital feature of any object oriented software which provides reuse of exiting classes for designing new classes. Higher reuse provides higher productivity and greater quality.Inheritance hierarchy is one of the very important artifacts targeted for measurement of reuse and reusability. Reuse through inheritance hierarchy can be measured from two dimensions- Depth and Breadth. Higher depth and breadth may increase complexity of software which makes the software difficult to understand and maintain. This paper aimed to correlate the depth and breadth of inheritance hierarchy with reuse and complexity of inheritance hierarchy using design oriented metrics.

  11. An extended integrable fractional-order KP soliton hierarchy

    Energy Technology Data Exchange (ETDEWEB)

    Li Li, E-mail: li07099@163.co [College of Maths and Systematic Science, Shenyang Normal University, Shenyang 110034 (China)

    2011-01-17

    In this Letter, we consider the modified derivatives and integrals of fractional-order pseudo-differential operators. A sequence of Lax KP equations hierarchy and extended fractional KP (fKP) hierarchy are introduced, and the fKP hierarchy has Lax presentations with the extended Lax operators. In the case of the extension with the half-order pseudo-differential operators, a new integrable fKP hierarchy is obtained. A few particular examples of fractional order will be listed, together with their Lax pairs.

  12. The analytic hierarchy process as a support for decision making

    Directory of Open Access Journals (Sweden)

    Filipović Milanka

    2007-01-01

    Full Text Available The first part of this text deals with a convention site selection as one of the most lucrative areas in the tourism industry. The second part gives a further description of a method for decision making - the analytic hierarchy process. The basic characteristics: hierarchy constructions and pair wise comparison on the given level of the hierarchy are allured. The third part offers an example of application. This example is solved using the Super - Decision software, which is developed as a computer support for the analytic hierarchy process. This indicates that the AHP approach is a useful tool to help support a decision of convention site selection. .

  13. Random walk hierarchy measure: What is more hierarchical, a chain, a tree or a star?

    Science.gov (United States)

    Czégel, Dániel; Palla, Gergely

    2015-01-01

    Signs of hierarchy are prevalent in a wide range of systems in nature and society. One of the key problems is quantifying the importance of hierarchical organisation in the structure of the network representing the interactions or connections between the fundamental units of the studied system. Although a number of notable methods are already available, their vast majority is treating all directed acyclic graphs as already maximally hierarchical. Here we propose a hierarchy measure based on random walks on the network. The novelty of our approach is that directed trees corresponding to multi level pyramidal structures obtain higher hierarchy scores compared to directed chains and directed stars. Furthermore, in the thermodynamic limit the hierarchy measure of regular trees is converging to a well defined limit depending only on the branching number. When applied to real networks, our method is computationally very effective, as the result can be evaluated with arbitrary precision by subsequent multiplications of the transition matrix describing the random walk process. In addition, the tests on real world networks provided very intuitive results, e.g., the trophic levels obtained from our approach on a food web were highly consistent with former results from ecology. PMID:26657012

  14. Random walk hierarchy measure: What is more hierarchical, a chain, a tree or a star?

    Science.gov (United States)

    Czégel, Dániel; Palla, Gergely

    2015-12-10

    Signs of hierarchy are prevalent in a wide range of systems in nature and society. One of the key problems is quantifying the importance of hierarchical organisation in the structure of the network representing the interactions or connections between the fundamental units of the studied system. Although a number of notable methods are already available, their vast majority is treating all directed acyclic graphs as already maximally hierarchical. Here we propose a hierarchy measure based on random walks on the network. The novelty of our approach is that directed trees corresponding to multi level pyramidal structures obtain higher hierarchy scores compared to directed chains and directed stars. Furthermore, in the thermodynamic limit the hierarchy measure of regular trees is converging to a well defined limit depending only on the branching number. When applied to real networks, our method is computationally very effective, as the result can be evaluated with arbitrary precision by subsequent multiplications of the transition matrix describing the random walk process. In addition, the tests on real world networks provided very intuitive results, e.g., the trophic levels obtained from our approach on a food web were highly consistent with former results from ecology.

  15. Gravitational inflaton decay and the hierarchy problem

    CERN Document Server

    Watanabe, Yuki

    2007-01-01

    We study implications of the large-N species solution to the hierarchy problem, proposed by G. Dvali, for reheating of the universe after inflation. Dvali's proposal contains additional N~10^{32} Z_2-conserved quantum fields beyond the Standard Model particles with mass ~1 TeV, which weaken gravity by a factor of 1/N, and thus explain the hierarchy between the Plank scale and the electroweak scale. We show that, in this scenario, the decay rates of inflaton fields through gravitational decay channels are enhanced by a factor of N, and thus they decay into N species of the quantum fields very efficiently, in the limit that quantum gravity effects are unimportant for the gravitational decay rate. In order not to over-reheat the universe, inflaton mass, vacuum expectation value of inflaton, or non-minimal gravitational coupling should be tightly fine-tuned. Our conclusion holds even when the gravitational decay is prohibited by some symmetry of the theory; the universe may still be over-reheated via annihilation...

  16. Instability-induced hierarchy in bipedal locomotion

    Science.gov (United States)

    Ohgane, Kunishige; Ueda, Kei-Ichi

    2008-05-01

    One of the important features of human locomotion is its instant adaptability to various unpredictable changes of physical and environmental conditions. This property is known as flexibility. Modeling the bipedal locomotion system, we show that initial-state coordination by a global variable which encodes the attractor basins of the system can yield flexibility. This model is based on the following hypotheses: (i) the walking velocity is a global variable, and (ii) the leg posture at the beginning of the stance phase is the initial state of the gait. Moreover, we confirm these hypotheses. We investigate the regions near the neutral states between walking and falling phases using numerical experiments and demonstrate that global variables can be defined as the dominant unstable directions of the system dynamics near the neutral states. We propose the concept of an “instability-induced hierarchy.” In this hierarchy, global variables govern other variables near neutral states; i.e., they become elements of a higher level.

  17. Adapting Memory Hierarchies for Emerging Datacenter Interconnects

    Institute of Scientific and Technical Information of China (English)

    江涛; 董建波; 侯锐; 柴琳; 张立新; 孙凝晖; 田斌

    2015-01-01

    Efficient resource utilization requires that emerging datacenter interconnects support both high performance communication and efficient remote resource sharing. These goals require that the network be more tightly coupled with the CPU chips. Designing a new interconnection technology thus requires considering not only the interconnection itself, but also the design of the processors that will rely on it. In this paper, we study memory hierarchy implications for the design of high-speed datacenter interconnects—particularly as they affect remote memory access—and we use PCIe as the vehicle for our investigations. To that end, we build three complementary platforms: a PCIe-interconnected prototype server with which we measure and analyze current bottlenecks; a software simulator that lets us model microarchitectural and cache hierarchy changes;and an FPGA prototype system with a streamlined switchless customized protocol Thunder with which we study hardware optimizations outside the processor. We highlight several architectural modifications to better support remote memory access and communication, and quantify their impact and limitations.

  18. Retribution as hierarchy regulation: Hierarchy preferences moderate the effect of offender socioeconomic status on support for retribution.

    Science.gov (United States)

    Redford, Liz; Ratliff, Kate A

    2017-09-17

    People punish others for various reasons, including deterring future crime, incapacitating the offender, and retribution, or payback. The current research focuses on retribution, testing whether support for retribution is motivated by the desire to maintain social hierarchies. If so, then the retributive tendencies of hierarchy enhancers or hierarchy attenuators should depend on whether offenders are relatively lower or higher in status, respectively. Three studies showed that hierarchy attenuators were more retributive against high-status offenders than for low-status offenders, that hierarchy enhancers showed a stronger orientation towards retributive justice, and that relationship was stronger for low-status, rather than high-status, criminal offenders. These findings clarify the purpose and function of retributive punishment. They also reveal how hierarchy-regulating motives underlie retribution, motives which, if allowed to influence judgements, may contribute to biased or ineffective justice systems. © 2017 The British Psychological Society.

  19. ON GAUGE EQUIVALENT INTEGRABLE SYSTEMS AND r-MATRICES FOR AKNS HIERARCHY AND A COUPLED MKdV HIERARCHY

    Institute of Scientific and Technical Information of China (English)

    刘响林; 陈庆辉; 张保才

    2003-01-01

    The new coupled MKdV hierarchy is obtained. By using gauge transformation,the corns trained flow, the integrable system and Lax representation for the coupled MKdVhierarchy were first corstructed from the AKNS hierarchy and then using the Laxrepresentation, the r-matrix for the constrained flow of the coupled MKdV hierarchy wasconstructed. The second set of conserved integrals of this constrained flow and theirinvolutivity were also given.

  20. Emergence of functional hierarchy in a multiple timescale neural network model: a humanoid robot experiment.

    Directory of Open Access Journals (Sweden)

    Yuichi Yamashita

    2008-11-01

    Full Text Available It is generally thought that skilled behavior in human beings results from a functional hierarchy of the motor control system, within which reusable motor primitives are flexibly integrated into various sensori-motor sequence patterns. The underlying neural mechanisms governing the way in which continuous sensori-motor flows are segmented into primitives and the way in which series of primitives are integrated into various behavior sequences have, however, not yet been clarified. In earlier studies, this functional hierarchy has been realized through the use of explicit hierarchical structure, with local modules representing motor primitives in the lower level and a higher module representing sequences of primitives switched via additional mechanisms such as gate-selecting. When sequences contain similarities and overlap, however, a conflict arises in such earlier models between generalization and segmentation, induced by this separated modular structure. To address this issue, we propose a different type of neural network model. The current model neither makes use of separate local modules to represent primitives nor introduces explicit hierarchical structure. Rather than forcing architectural hierarchy onto the system, functional hierarchy emerges through a form of self-organization that is based on two distinct types of neurons, each with different time properties ("multiple timescales". Through the introduction of multiple timescales, continuous sequences of behavior are segmented into reusable primitives, and the primitives, in turn, are flexibly integrated into novel sequences. In experiments, the proposed network model, coordinating the physical body of a humanoid robot through high-dimensional sensori-motor control, also successfully situated itself within a physical environment. Our results suggest that it is not only the spatial connections between neurons but also the timescales of neural activity that act as important mechanisms

  1. Emergence of functional hierarchy in a multiple timescale neural network model: a humanoid robot experiment.

    Science.gov (United States)

    Yamashita, Yuichi; Tani, Jun

    2008-11-01

    It is generally thought that skilled behavior in human beings results from a functional hierarchy of the motor control system, within which reusable motor primitives are flexibly integrated into various sensori-motor sequence patterns. The underlying neural mechanisms governing the way in which continuous sensori-motor flows are segmented into primitives and the way in which series of primitives are integrated into various behavior sequences have, however, not yet been clarified. In earlier studies, this functional hierarchy has been realized through the use of explicit hierarchical structure, with local modules representing motor primitives in the lower level and a higher module representing sequences of primitives switched via additional mechanisms such as gate-selecting. When sequences contain similarities and overlap, however, a conflict arises in such earlier models between generalization and segmentation, induced by this separated modular structure. To address this issue, we propose a different type of neural network model. The current model neither makes use of separate local modules to represent primitives nor introduces explicit hierarchical structure. Rather than forcing architectural hierarchy onto the system, functional hierarchy emerges through a form of self-organization that is based on two distinct types of neurons, each with different time properties ("multiple timescales"). Through the introduction of multiple timescales, continuous sequences of behavior are segmented into reusable primitives, and the primitives, in turn, are flexibly integrated into novel sequences. In experiments, the proposed network model, coordinating the physical body of a humanoid robot through high-dimensional sensori-motor control, also successfully situated itself within a physical environment. Our results suggest that it is not only the spatial connections between neurons but also the timescales of neural activity that act as important mechanisms leading to functional

  2. Unique selectivity reversal in Am(3+)-Eu(3+) extraction in a tripodal TREN-based diglycolamide in ionic liquid: extraction, luminescence, complexation and structural studies.

    Science.gov (United States)

    Leoncini, Andrea; Mohapatra, Prasanta K; Bhattacharyya, Arunasis; Raut, Dhaval R; Sengupta, Arijit; Verma, Parveen K; Tiwari, Nidhi; Bhattacharyya, Dibyendu; Jha, Sambhunath; Wouda, Anna M; Huskens, Jurriaan; Verboom, Willem

    2016-02-14

    An N-pivot diglycolamide extractant (DGA-TREN) was synthesized for the first time and its complexation behaviour was studied towards trivalent lanthanide/actinide ions. The solvent extraction studies suggested a unique selectivity reversal in the extraction of trivalent actinides versus trivalent lanthanides which was observed performing extraction studies in an ionic liquid vis-à-vis a molecular diluent for a tripodal TREN-based diglycolamide ligand (DGA-TREN) vs. a tripodal diglycolamide ligand (T-DGA) which may have great significance in radioactive waste remediation. The nature of the bonding to Eu(3+) ion was investigated by EXAFS as well as by DFT calculations.

  3. Pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of family: A forensic approach to identify family hierarchy.

    Science.gov (United States)

    Mala, Sankeerti; Rathod, Vanita; Pundir, Siddharth; Dixit, Sudhanshu

    2017-01-01

    The unique pattern and structural diversity of fingerprints, lip prints, palatal rugae, and their occurrence in different patterns among individuals make it questionable whether they are completely unique even in a family hierarchy? Do they have any repetition of the patterns among the generations? Or is this a mere chaos theory? The present study aims to assess the pattern self-repetition of fingerprints, lip prints, and palatal rugae among three generations of ten different families. The present study was conducted at Rungta College of Dental Science and Research, Bhilai, India. Participants birth by origin of Chhattisgarh were only included in the study. Thirty participants from three consecutive generations of ten different families were briefed about the purpose of the study, and their fingerprints, lip prints, and palatal rugae impression were recorded and analyzed for the pattern of self-repetition. Multiple comparisons among the generations and one-way analysis of variance test were performed using SPSS 20 trial version. Among the pattern of primary palatal rugae, 10% showed repetition in all the three generations. Thirty percent showed repetition of the pattern of thumb fingerprints in all the three generation. The pattern of lip prints in the middle 1/3(rd) of lower lip, 20% showed repetition in alternative generations. The evaluations of fingerprints, lip prints, and palatal rugae showed fractal dimensions, occurring variations in dimensions according to the complexity of each structure. Even though a minute self-repetition in the patterns of lip, thumb, and palate among the three consequent generations in a family was observed considering the sample size, these results need to be confirmed in a larger sample, either to establish the role of chaos theory in forensic science or identifying a particular pattern of the individual in his family hierarchy.

  4. Unique Access to Learning

    Science.gov (United States)

    Goble, Don

    2009-01-01

    This article describes the many learning opportunities that broadcast technology students at Ladue Horton Watkins High School in St. Louis, Missouri, experience because of their unique access to technology and methods of learning. Through scaffolding, stepladder techniques, and trial by fire, students learn to produce multiple television programs,…

  5. Analysis on River Hierarchy and Ecological Structure of Donghe River in Three Gorges Reservoir Area%三峡库区东河河流等级及生态结构分析

    Institute of Scientific and Technical Information of China (English)

    熊森; 刘红; 王强; 黎璇

    2011-01-01

    Stream hierarchy of Dong be River was analyed by using GIS technology. The total watershed of Dong he River was divided into six grades. Relationship between river grade and elevation and slope was researched. The result indicated that river with higher grade distributed in those areas with smaller slope and lower elevation. Vegetation in watershed of lower grade stream is better than that in watershed of higher grade. The first and second grade streams were influenced by natural disturbance and maintained high quality of ecosystem integrality. The third and fourth grade rivers with high water slope and rich hydropower potential were significantly influenced by small hydropower. Ecological water demand of the reach in the downstream of dam should be released in order to maintain habitat connexity and river health. The fifth and sixth grade rivers were influenced by intensive anthropogenic disturbance with poor water quality. Riparian vegetation with high diversity and multi layers should be reestablished in this area to decrease non-point source pollution. Ecological engineering should be carryied out in reach influenced which was by the fluctuation of the Three Gorges Reservoir in order to improve its landscape quality.%利用GIS技术进行河流等级结构划分,研究了三峡库区东河流域河流的等级体系.将整个东河流域河溪分为6级,并在此基础上研究了不同等级河溪与海拔高程和坡度的关系.研究发现,河溪在由低等级向高等级变化时,其空间分布范围逐渐由坡度大、海拔高向坡度小、低海拔的平缓地带过渡;低等级溪流周围植被生长状况好于高等级溪流周围植被.东河1、2级河流生态结构的完整性主要受自然干扰影响.3、4级河流水体落差大,水能丰富,河流主要受小水电影响;建议充分考虑河流生态需水,维护河流生境的连通性,保证水坝下游河段的河流生态健康.5、6级河流沿岸人为活动强度较大,水

  6. Face the hierarchy: ERP and oscillatory brain responses in social rank processing.

    Science.gov (United States)

    Breton, Audrey; Jerbi, Karim; Henaff, Marie-Anne; Cheylus, Anne; Baudouin, Jean-Yves; Schmitz, Christina; Krolak-Salmon, Pierre; Van der Henst, Jean-Baptiste

    2014-01-01

    Recognition of social hierarchy is a key feature that helps us navigate through our complex social environment. Neuroimaging studies have identified brain structures involved in the processing of hierarchical stimuli but the precise temporal dynamics of brain activity associated with such processing remains largely unknown. Here, we used electroencephalography to examine the effect of social hierarchy on neural responses elicited by faces. In contrast to previous studies, the key manipulation was that a hierarchical context was constructed, not by varying facial expressions, but by presenting neutral-expression faces in a game setting. Once the performance-based hierarchy was established, participants were presented with high-rank, middle-rank and low-rank player faces and had to evaluate the rank of each face with respect to their own position. Both event-related potentials and task-related oscillatory activity were investigated. Three main findings emerge from the study. First, the experimental manipulation had no effect on the early N170 component, which may suggest that hierarchy did not modulate the structural encoding of neutral-expression faces. Second, hierarchy significantly modulated the amplitude of the late positive potential (LPP) within a 400-700 ms time-window, with more a prominent LPP occurring when the participants processed the face of the highest-rank player. Third, high-rank faces were associated with the highest reduction of alpha power. Taken together these findings provide novel electrophysiological evidence for enhanced allocation of attentional resource in the presence of high-rank faces. At a broader level, this study brings new insights into the neural processing underlying social categorization.

  7. The Prelle-Singer method and Painlevé hierarchies

    Energy Technology Data Exchange (ETDEWEB)

    Gordoa, P. R.; Pickering, A. [Departamento de Matemática Aplicada, Universidad Rey Juan Carlos, C/ Tulipán s/n, 28933 Móstoles, Madrid (Spain); Senthilvelan, M. [Centre for Nonlinear Dynamics, School of Physics, Bharathidasan University, Tiruchirapalli - 620 024 (India)

    2014-05-15

    We consider systems of ordinary differential equations (ODEs) of the form BK=0, where B is a Hamiltonian operator of a completely integrable partial differential equation hierarchy, and K = (K, L){sup T}. Such systems, while of quite low order and linear in the components of K, may represent higher-order nonlinear systems if we make a choice of K in terms of the coefficient functions of B. Indeed, our original motivation for the study of such systems was their appearance in the study of Painlevé hierarchies, where the question of the reduction of order is of great importance. However, here we do not consider such particular cases; instead we study such systems for arbitrary K, where they may represent both integrable and nonintegrable systems of ordinary differential equations. We consider the application of the Prelle-Singer (PS) method—a method used to find first integrals—to such systems in order to reduce their order. We consider the cases of coupled second order ODEs and coupled third order ODEs, as well as the special case of a scalar third order ODE; for the case of coupled third order ODEs, the development of the PS method presented here is new. We apply the PS method to examples of such systems, based on dispersive water wave, Ito and Korteweg-de Vries Hamiltonian structures, and show that first integrals can be obtained. It is important to remember that the equations in question may represent sequences of systems of increasing order. We thus see that the PS method is a further technique which we expect to be useful in our future work.

  8. Inequality Matters : Classroom Status Hierarchy and Adolescents' Bullying

    NARCIS (Netherlands)

    Garandeau, Claire F.; Lee, Ihno A.; Salmivalli, Christina

    2014-01-01

    The natural emergence of status hierarchies in adolescent peer groups has long been assumed to help prevent future intragroup aggression. However, clear evidence of this beneficial influence is lacking. In fact, few studies have examined between-group differences in the degree of status hierarchy (d

  9. The Diversity Education Dilemma: Exposing Status Hierarchies without Reinforcing Them

    Science.gov (United States)

    Amoroso, Lisa M.; Loyd, Denise Lewin; Hoobler, Jenny M.

    2010-01-01

    A "diversity education dilemma" occurs when exposure to information concerning status hierarchies, related to demographic and other socially salient identity groups, reinforces those hierarchies in the classroom. Discussions of diversity-related issues in a variety of management courses (e.g., immigrant issues in labor relations, the composition…

  10. Criteria for optimizing cortical hierarchies with continuous ranges

    Directory of Open Access Journals (Sweden)

    Antje Krumnack

    2010-03-01

    Full Text Available In a recent paper (Reid et al.; 2009, NeuroImage we introduced a method to calculate optimal hierarchies in the visual network that utilizes continuous, rather than discrete, hierarchical levels, and permits a range of acceptable values rather than attempting to fit fixed hierarchical distances. There, to obtain a hierarchy, the sum of deviations from the constraints that define the hierarchy was minimized using linear optimization. In the short time since publication of that paper we noticed that many colleagues misinterpreted the meaning of the term optimal hierarchy. In particular, a majority of them were under the impression that there was perhaps only one optimal hierarchy, but a substantial difficulty in finding that one. However, there is not only more than one optimal hierarchy but also more than one option for defining optimality. Continuing the line of this work we look at additional options for optimizing the visual hierarchy: minimizing the number of violated constraints and minimizing the maximal size of a constraint violation using linear optimization and mixed integer programming. The implementation of both optimization criteria is explained in detail. In addition, using constraint sets based on the data from Felleman and Van Essen, optimal hierarchies for the visual network are calculated for both optimization methods.

  11. Inferring heuristic classification hierarchies from natural language input

    Science.gov (United States)

    Hull, Richard; Gomez, Fernando

    1993-01-01

    A methodology for inferring hierarchies representing heuristic knowledge about the check out, control, and monitoring sub-system (CCMS) of the space shuttle launch processing system from natural language input is explained. Our method identifies failures explicitly and implicitly described in natural language by domain experts and uses those descriptions to recommend classifications for inclusion in the experts' heuristic hierarchies.

  12. Reactions to Crime as a Hierarchy Regulating Strategy:

    DEFF Research Database (Denmark)

    Green, Eva G. T.; Thomsen, Lotte; Sidanius, Jim;

    2009-01-01

    Across two studies, we demonstrated that support for group-based hierarchies differentially affects evaluation of ingroup and outgroup criminal offenders and that this effect generalizes to overall evaluations of their respective groups. Drawing on social dominance theory, our results show...... of ethnicity or nationality, not education level and employment status, were the important cues for hierarchy-regulating judgments of criminal offenders...

  13. A Validation Study of Maslow's Hierarchy of Needs Theory.

    Science.gov (United States)

    Clay, Rex J.

    A study was conducted to expand the body of research that tests the validity of Abraham Maslow's hierarchy of needs theory in a work context where it often serves as a guide for the supervisor's relationships with his subordinates. Data was gathered by questionnaire which tested for a hierarchy of needs among instructors at four community colleges…

  14. Genus-zero Whitham hierarchies in conformal-map dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Alonso, Luis [Departamento de Fisica Teorica II, Universidad Complutense, E-28040 Madrid (Spain)]. E-mail: luism@fis.ucm.es; Medina, Elena [Departamento de Matematicas, Universidad de Cadiz, E-11510 Puerto Real, Cadiz (Spain)

    2006-10-26

    A scheme for solving quasiclassical string equations is developed to prove that genus-zero Whitham hierarchies describe the deformations of planar domains determined by rational conformal maps. This property is applied in normal matrix models to show that deformations of simply-connected supports of eigenvalues under changes of coupling constants are governed by genus-zero Whitham hierarchies.

  15. A Validation Study of Maslow's Hierarchy of Needs Theory.

    Science.gov (United States)

    Clay, Rex J.

    A study was conducted to expand the body of research that tests the validity of Abraham Maslow's hierarchy of needs theory in a work context where it often serves as a guide for the supervisor's relationships with his subordinates. Data was gathered by questionnaire which tested for a hierarchy of needs among instructors at four community colleges…

  16. Integrable dispersionless KdV hierarchy with sources

    OpenAIRE

    2006-01-01

    An integrable dispersionless KdV hierarchy with sources (dKdVHWS) is derived. Lax pair equations and bi-Hamiltonian formulation for dKdVHWS are formulated. Hodograph solution for the dispersionless KdV equation with sources (dKdVWS) is obtained via hodograph transformation. Furthermore, the dispersionless Gelfand-Dickey hierarchy with sources (dGDHWS) is presented.

  17. Detecting Hidden Hierarchy of Non Hierarchical Terrorist Networks

    DEFF Research Database (Denmark)

    Memon, Nasrullah

    to analyze terrorist networks and prioritize their targets. Applying recently introduced mathematical methods for constructing the hidden hierarchy of "nonhierarchical" terrorist networks; we present case studies of the terrorist attacks occurred / planned in the past, in order to identify hidden hierarchy...

  18. Penentuan Peringkat Bahaya Tsunami dengan Metode Analytical Hierarchy Process (Studi kasus: Wilayah Pesisir Kabupaten Sukabumi

    Directory of Open Access Journals (Sweden)

    Oki Oktariadi

    2014-06-01

    Full Text Available http://dx.doi.org/10.17014/ijog.vol4no2.20093Hierarchy structure of a tsunami risk encompasses the study of hazard, vulnerability, and capac- ity factors. The focus of this research is hazard factors, with indicators comprise beach slope, beach coarseness (surface material, run up, and earthquake intensity. Computation method used in the deci- sion system is the Analytical Hierarchy Process (AHP. The AHP method is to determine the weight of indicators and matrices of hazard factor hierarchy. The final total score of the hazard factors will be useful for tsunami hazard mapping through a geographic information system (GIS. It consists of four hierarchies of  tsunami hazard that are high, middle, low, and safe levels. The coastal regions in Sukabumi having high tsunami disaster risk are the Gulf of Pelabuhanratu, Ciemas plain (Gulf of Ciletuh, Ujung Genteng Cape, and some parts of coastal plain areas in Sim- penan. Those having middle tsunami disaster risk are coastal area of Surade, Cibitung, Tegalbuleud, whereas those having low tsunami disaster risk are Cisolok cliff, Simpenan, and Ciemas cliff area. The other coastal zones are included into a safe area.  

  19. Challenging knowledge hierarchies: working toward sustainable development in Sri Lanka's energy sector

    Directory of Open Access Journals (Sweden)

    Dean Nieusma

    2007-02-01

    Full Text Available This paper analyzes sustainable development practices within Sri Lanka’s energy sector. It directs attention to how expertise functions in development decision making in ways that can unintentionally inhibit sustainable development. Understanding expertise as merely specialized knowledge clouds its role as a social activity. In practice, expertise is a combination of knowledge and authority, and expert knowledge exists within a hierarchically ordered authority structure of diverse knowledge domains—what is referred to here as “knowledge hierarchies.” Knowledge hierarchies exclude the participation of some relevant knowledge domains, and thereby preclude the possibility of local sustainable development. The Energy Forum of Sri Lanka, a small renewable energy advocacy organization, strives to enable sustainability by going beyond facile calls for greater inclusion to confront the mechanisms of exclusion. The paper documents three of the Energy Forum’s development interventions intended to level out the knowledge hierarchy that inhibits sustainable energy development in Sri Lanka. Drawing insights from the Energy Forum’s approach, the paper argues that experts who wish to contribute to sustainable development must attend to the knowledge hierarchies in which they operate to ensure that their own authority does not exclude other relevant knowledge domains.

  20. Scale-independent inflation and hierarchy generation

    Directory of Open Access Journals (Sweden)

    Pedro G. Ferreira

    2016-12-01

    Full Text Available We discuss models involving two scalar fields coupled to classical gravity that satisfy the general criteria: (i the theory has no mass input parameters, (ii classical scale symmetry is broken only through −112ςϕ2R couplings where ς departs from the special conformal value of 1; (iii the Planck mass is dynamically generated by the vacuum expectations values (VEVs of the scalars (iv there is a stage of viable inflation associated with slow roll in the two-scalar potential; (v the final vacuum has a small to vanishing cosmological constant and an hierarchically small ratio of the VEVs and the ratio of the scalar masses to the Planck scale. This assumes the paradigm of classical scale symmetry as a custodial symmetry of large hierarchies.

  1. Scale-Independent Inflation and Hierarchy Generation

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Pedro G. [Oxford U.; Hill, Christopher T. [Fermilab; Ross, Graham G. [Oxford U., Theor. Phys.

    2016-03-18

    We discuss models involving two scalar fields coupled to classical gravity that satisfy the general criteria: (i) the theory has no mass input parameters, (ii) classical scale symmetry is broken only through $-\\frac{1}{12}\\varsigma \\phi^2 R$ couplings where $\\varsigma$ departs from the special conformal value of $1$; (iii) the Planck mass is dynamically generated by the vacuum expectations values (VEVs) of the scalars (iv) there is a stage of viable inflation associated with slow roll in the two--scalar potential; (v) the final vacuum has a small to vanishing cosmological constant and an hierarchically small ratio of the VEVs and the ratio of the scalar masses to the Planck scale. This assumes the paradigm of classical scale symmetry as a custodial symmetry of large hierarchies.

  2. A new wavefunction hierarchy for interacting geminals

    Science.gov (United States)

    Limacher, Peter A.

    2016-11-01

    A new truncation scheme for non-orthogonal antisymmetrized products of interacting geminals (APIG) is introduced based on antisymmetrized products of strongly orthogonal geminals (APSG). This wavefunction hierarchy of interacting geminals (IG) allows us to gradually increase the accuracy at which the ground state of a seniority-zero Hamiltonian can be estimated, ranging from APSG up to approximation-free APIG. Mathematical expressions for the lowest four orders (IG0, IG1, IG2, and IG3) are given explicitly and the computational cost to evaluate their transition density matrix is verified to scale only cubically with system size. Exemplary numerical calculations indicate that already a very early truncation level leads to results virtually identical to APIG.

  3. Scale-Independent Inflation and Hierarchy Generation

    CERN Document Server

    Ferreira, Pedro G; Ross, Graham G

    2016-01-01

    We discuss models involving two scalar fields coupled to classical gravity that satisfy the general criteria: (i) the theory has no mass input parameters, (ii) classical scale symmetry is broken only through $-\\frac{1}{12}\\varsigma \\phi^2 R$ couplings where $\\varsigma$ departs from the special conformal value of $1$; (iii) the Planck mass is dynamically generated by the vacuum expectations values (VEVs) of the scalars (iv) there is a stage of viable inflation associated with slow roll in the two--scalar potential; (v) the final vacuum has a small to vanishing cosmological constant and an hierarchically small ratio of the VEVs and the ratio of the scalar masses to the Planck scale. This assumes the paradigm of classical scale symmetry as a custodial symmetry of large hierarchies.

  4. Simple Resonance Hierarchy for Surmounting Quantum Uncertainty

    Science.gov (United States)

    Amoroso, Richard L.

    2010-12-01

    For a hundred years violation or surmounting the Quantum Uncertainty Principle has remained a Holy Grail of both theoretical and empirical physics. Utilizing an operationally completed form of Quantum Theory cast in a string theoretic Higher Dimensional (HD) form of Dirac covariant polarized vacuum with a complex Einstein energy dependent spacetime metric, M̂4±C4 with sufficient degrees of freedom to be causally free of the local quantum state, we present a simple empirical model for ontologically surmounting the phenomenology of uncertainty through a Sagnac Effect RF pulsed Laser Oscillated Vacuum Energy Resonance hierarchy cast within an extended form of a Wheeler-Feynman-Cramer Transactional Calabi-Yau mirror symmetric spacetime bachcloth.

  5. Scale-independent inflation and hierarchy generation

    Science.gov (United States)

    Ferreira, Pedro G.; Hill, Christopher T.; Ross, Graham G.

    2016-12-01

    We discuss models involving two scalar fields coupled to classical gravity that satisfy the general criteria: (i) the theory has no mass input parameters, (ii) classical scale symmetry is broken only through -1/12 ςϕ2 R couplings where ς departs from the special conformal value of 1; (iii) the Planck mass is dynamically generated by the vacuum expectations values (VEVs) of the scalars (iv) there is a stage of viable inflation associated with slow roll in the two-scalar potential; (v) the final vacuum has a small to vanishing cosmological constant and an hierarchically small ratio of the VEVs and the ratio of the scalar masses to the Planck scale. This assumes the paradigm of classical scale symmetry as a custodial symmetry of large hierarchies.

  6. HCM-Linked Δ 160E Cardiac Troponin T Mutation Causes Unique Progressive Structural and Molecular Ventricular Remodeling in Transgenic Mice

    Science.gov (United States)

    Moore, Rachel K.; Grinspan, Lauren Tal; Jimenez, Jesus; Guinto, Pia J.; Ertz-Berger, Briar; Tardiff, Jil C.

    2013-01-01

    Hypertrophic cardiomyopathy (HCM) is a primary disease of cardiac muscle, and one of the most common causes of sudden cardiac death (SCD) in young people. Many mutations in cardiac troponin T (cTnT) lead to a complex form of HCM with varying degrees of ventricular hypertrophy and ~65% of all cTnT mutations occur within or flanking the elongated N-terminal TNT1 domain. Biophysical studies have predicted that distal TNT1 mutations, including Δ160E, cause disease by a novel, yet unknown mechanism as compared to N-terminal mutations. To begin to address the specific effects of this commonly observed cTnT mutation we generated two independent transgenic mouse lines carrying variant doses of the mutant transgene. Hearts from the 30% and 70% cTnT Δ160E lines demonstrated a highly unique, dose-dependent disruption in cellular and sarcomeric architecture and a highly progressive pattern of ventricular remodeling. While adult ventricular myocytes isolated from Δ160E transgenic mice exhibited dosage-independent mechanical impairments, decreased sarcoplasmic reticulum calcium load and SERCA2a calcium uptake activity, the observed decreases in calcium transients were dosage-dependent. The latter findings were concordant with measures of calcium regulatory proteins abundance and phosphorylation state. Finally, studies of whole heart physiology in the isovolumic mode demonstrated dose-dependent differences in the degree of cardiac dysfuction. We conclude that the observed clinical severity of the cTnT Δ160E mutation is caused by a combination of direct sarcomeric disruption coupled to a profound disregulation of Ca2+ homeostasis at the cellular level that results in a unique and highly progressive pattern of ventricular remodeling. PMID:23434821

  7. Constrained KP Hierarchies Additional Symmetries, Darboux-Bäcklund Solutions and Relations to Multi-Matrix Models

    CERN Document Server

    Aratyn, H; Pacheva, S

    1996-01-01

    This paper provides a systematic description of the interplay between a specific class of reductions denoted as \\cKPrm ($r,m \\geq 1$) of the primary continuum integrable system -- the Kadomtsev-Petviashvili ({\\sf KP}) hierarchy and discrete multi-matrix models. The relevant integrable \\cKPrm structure is a generalization of the familiar $r$-reduction of the full {\\sf KP} hierarchy to the $SL(r)$ generalized KdV hierarchy ${\\sf cKP}_{r, 0}$. The important feature of \\cKPrm hierarchies is the presence of a discrete symmetry structure generated by successive Darboux-Bãcklund (DB) transformations. This symmetry allows for expressing the relevant tau-functions as Wronskians within a formalism which realizes the tau-functions as DB orbits of simple initial solutions. In particular, it is shown that any DB orbit of a ${\\sf cKP}_{r,1}$ defines a generalized 2-dimensional Toda lattice structure. Furthermore, we consider the class of truncated {\\sf KP} hierarchies ({\\sl i.e.}, those defined via Wilson-Sato dressing op...

  8. Lepton mass hierarchy from the quark mass hierarchy in the light of the quark Technicolor Dynamics

    CERN Document Server

    Sauli, Vladimir

    2013-01-01

    We explore the possibility that all electroweak symmetry breaking (EWSB) comes from the strong dynamics of Technicolor while these are the only quarks which receive masses through Technicolor dynamics. We assume the leptons are not embedded in a representation of Extended Technigroup. In this paper we suggest a model where the leptons receive their masses through the loop corrections which includes at least one closed quark loop. For this purpose we introduce model based on private family SU(2) scalar two doublets which interact very weakly with the Standard Model(SM) fermions and which do not condense at tree level. Assuming quark/lepton universality of suggested Yukawa interactions the model becomes strongly predictive and we calculate mass contributions to the all known SM lepton gauge eigenstates. Up to not yet explored mixing, the model suggests that the lepton mass hierarchy comes from the quark mass hierarchy. Within a single universal Yukawa coupling the absolute values of masses for neutrino family e...

  9. The Impact of Formal Hierarchies on Enterprise Social Networking Behavior

    DEFF Research Database (Denmark)

    Behrendt, Sebastian; Klier, Julia; Klier, Mathias

    2015-01-01

    With more and more companies using enterprise social networks (ESN) for employee communication and collaboration, the influence of ESN on organizational hierarchies has been subject of countless discussions in practice-oriented media and first academic studies. Conversely, the question whether...... and how formal organizational hierarchies influence ESN usage behavior has not yet been addressed. Drawing on a rich data set comprising 2.5 years of relationship building via direct messages, confirmed contact requests, and group messages, we are able to show that formal hierarchies have an important...... impact on social networking behavior. By applying means of social network analysis and supported by statements from interviews, we illustrate how deeply formal hierarchy impacts the three examined types of relationships. Our results motivate academics to further study the interrelation between hierarchy...

  10. "Ballet It's Too Whitey": Discursive Hierarchies of High School Dance Spaces and the Constitution of Embodied Feminine Subjectivities

    Science.gov (United States)

    Atencio, Matthew; Wright, Jan

    2009-01-01

    This article investigates (i) how the structuring practices and meanings associated with dance classes at an inner-city American high school operated as institutional spaces (re)producing "dividing practices" that supported racial and classed hierarchies; (ii) how these racist structures were created and maintained relative to dominant notions of…

  11. The crystal structure of an HSL-homolog EstE5 complex with PMSF reveals a unique configuration that inhibits the nucleophile Ser144 in catalytic triads.

    Science.gov (United States)

    Nam, Ki Hyun; Kim, Soo-Jin; Priyadarshi, Amit; Kim, Hyun Sook; Hwang, Kwang Yeon

    2009-11-13

    The esterase/lipase family (EC 3.1.1.3/EC 3.1.1.1) represents a diverse group of hydrolases that catalyze the cleavage of ester bonds and are widely distributed in animals, plants and microorganisms. Among these enzymes, hormone-sensitive lipases, play a critical role in the regulation of rodent fat cell lipolysis and are regarded as adipose tissue-specific enzymes. Recently, we reported the structural and biological characterization of EstE5 from the metagenome library [K.H. Nam, M.Y. Kim, S.J. Kim, A. Priyadarshi, W.H. Lee, K.Y. Hwang, Structural and functional analysis of a novel EstE5 belonging to the subfamily of hormone-sensitive lipase, Biochem. Biophys. Res. Commun. 379 (2009) 553-556]. The structure of this protein revealed that it belongs to the HSL-family. Here, we report the inhibition of the activity of the HSL-homolog EstE5 protein as determined by the use of esterase/lipase inhibitors. Our results revealed that the EstE5 protein is significantly inhibited by PMSF. In addition, this is the first study to identify the crystal structures of EstE5-PMSF at 2.4 and 2.5A among the HSL-homolog structures. This structural configuration is similar to that adopted when serine proteases are inhibited by PMSF. The results presented here provide valuable information regarding the properties of the HSL-family.

  12. Status hierarchy, attractiveness hierarchy and sex ratio : Three contextual factors explaining the status-aggression link among adolescents

    NARCIS (Netherlands)

    Zwaan, Michiel; Dijkstra, Jan; Veenstra, René

    2013-01-01

    The moderating effects of three specific conditions (status hierarchy, attractiveness hierarchy and sex ratio) on the link between status (popularity) and physical and relational aggression were examined in a large sample of adolescent boys (N = 1,665) and girls (N = 1,637) (M age = 13.60). In line

  13. Status hierarchy, attractiveness hierarchy and sex ratio : Three contextual factors explaining the status-aggression link among adolescents

    NARCIS (Netherlands)

    Zwaan, Michiel; Dijkstra, Jan; Veenstra, René

    The moderating effects of three specific conditions (status hierarchy, attractiveness hierarchy and sex ratio) on the link between status (popularity) and physical and relational aggression were examined in a large sample of adolescent boys (N = 1,665) and girls (N = 1,637) (M age = 13.60). In line

  14. Status Hierarchy, Attractiveness Hierarchy and Sex Ratio: Three Contextual Factors Explaining the Status-Aggression Link among Adolescents

    Science.gov (United States)

    Zwaan, Michiel; Dijkstra, Jan Kornelis; Veenstra, Rene

    2013-01-01

    The moderating effects of three specific conditions (status hierarchy, attractiveness hierarchy and sex ratio) on the link between status (popularity) and physical and relational aggression were examined in a large sample of adolescent boys ("N" = 1,665) and girls ("N" = 1,637) ("M" age = 13.60). In line with the…

  15. Selective gas adsorption and unique structural topology of a highly stable guest-free zeolite-type MOF material with N-rich chiral open channels.

    Science.gov (United States)

    Li, Jian-Rong; Tao, Ying; Yu, Qun; Bu, Xian-He; Sakamoto, Hirotoshi; Kitagawa, Susumu

    2008-01-01

    A new multifunctional di-topic tetrazolate-based ligand, 2,3-di-1H-tetrazol-5-ylpyrazine (H(2)dtp) has been designed and synthesized. The solvothermal reaction of this ligand with ZnCl(2) gave a robust guest-free three-dimensional zeolite-like chiral metal-organic framework (MOF) complex, [Zn(dtp)], which crystallized in chiral space group P6(1) and possessed chiral open channels with nitrogen-rich walls and the diameter of approximately 4.1 A. This framework presents a unique uniform etd (8,3) topology, is the first example of its type in MOFs, and exhibits high thermal stability with the decomposition temperature above 380 degrees C and permanent porosity. It is interesting that this material is able to selectively adsorb O(2) and CO(2) over N(2) gas, being a rare example in MOFs. In addition, C(2)H(2) and MeOH adsorption results show that although the framework channel holds nitrogen-rich walls that may provide H-bonding sites, no NH H-bond effect between the guest molecules and microporous surface was observed.

  16. Hierarchy of Gene Expression as a Biomarker for Breast Cancer Prognosis

    Science.gov (United States)

    Chen, Man

    2013-03-01

    Cancer is a dedifferentiation of healthy cellular and genetic processes. At the same time, specific oncological pathways are activated in the cancer state. Cancer metastasis exposes cancer cells to a variety of microenvironments, in which physics of evolution suggests modularity is a relevant order parameter. We were thus motivated to examine the structure in gene and tissue networks of breast cancer patients. We studied the relation between metastasis and breast cancer network structure. We found that hierarchy of cancer networks distinguishes non-metastatic from metastatic patient populations. We also found that for cancer-associated genes, likelihood of metastasis is correlated with increased network hierarchy. Conversely for tissue networks using all gene data, reduced network structure is correlated with likelihood of metastasis. We suggest hierarchy of gene expression may be useful as a biomarker for breast cancer breast cancer metastasis and recurrence. For those patients with reduced structure, which is at least 5% of the patient population, this biomarker provides a strong signal for likelihood of cancer metastasis.

  17. NASA's unique networking environment

    Science.gov (United States)

    Johnson, Marjory J.

    1988-01-01

    Networking is an infrastructure technology; it is a tool for NASA to support its space and aeronautics missions. Some of NASA's networking problems are shared by the commercial and/or military communities, and can be solved by working with these communities. However, some of NASA's networking problems are unique and will not be addressed by these other communities. Individual characteristics of NASA's space-mission networking enviroment are examined, the combination of all these characteristics that distinguish NASA's networking systems from either commercial or military systems is explained, and some research areas that are important for NASA to pursue are outlined.

  18. Optimal Intra-Urban Hierarchy of Activity Centers—A Minimized Household Travel Energy Consumption Approach

    Directory of Open Access Journals (Sweden)

    Jie Zhang

    2015-08-01

    Full Text Available An intra-urban hierarchy of activity centers interconnected by non-motorized and public transportation is broadly believed to be the ideal urban spatial structure for sustainable cities. However, the proper hinterland area for centers at each level lacks empirical study. Based on the concentric structure of everyday travel distances, working centers, shopping centers, and neighborhood centers are extracted from corresponding types of POIs in 286 Chinese cities at the prefectural level and above. A U-shaped curve between Household Transportation Energy Consumption (HTEC per capita and center density at each of the three levels has been found through regression analysis. An optimal intra-urban hierarchy of activity centers is suggested to construct energy-efficient cities.

  19. Unique fluorophores in the dimeric archaeal histones hMfB and hPyA1 reveal the impact of nonnative structure in a monomeric kinetic intermediate.

    Science.gov (United States)

    Stump, Matthew R; Gloss, Lisa M

    2008-02-01

    Homodimeric archaeal histones and heterodimeric eukaryotic histones share a conserved structure but fold through different kinetic mechanisms, with a correlation between faster folding/association rates and the population of kinetic intermediates. Wild-type hMfB (from Methanothermus fervidus) has no intrinsic fluorophores; Met35, which is Tyr in hyperthermophilic archaeal histones such as hPyA1 (from Pyrococcus strain GB-3A), was mutated to Tyr and Trp. Two Tyr-to-Trp mutants of hPyA1 were also characterized. All fluorophores were introduced into the long, central alpha-helix of the histone fold. Far-UV circular dichroism (CD) indicated that the fluorophores did not significantly alter the helical content of the histones. The equilibrium unfolding transitions of the histone variants were two-state, reversible processes, with DeltaG degrees (H2O) values within 1 kcal/mol of the wild-type dimers. The hPyA1 Trp variants fold by two-state kinetic mechanisms like wild-type hPyA1, but with increased folding and unfolding rates, suggesting that the mutated residues (Tyr-32 and Tyr-36) contribute to transition state structure. Like wild-type hMfB, M35Y and M35W hMfB fold by a three-state mechanism, with a stopped-flow CD burst-phase monomeric intermediate. The M35 mutants populate monomeric intermediates with increased secondary structure and stability but exhibit decreased folding rates; this suggests that nonnative interactions occur from burial of the hydrophobic Tyr and Trp residues in this kinetic intermediate. These results implicate the long central helix as a key component of the structure in the kinetic monomeric intermediates of hMfB as well as the dimerization transition state in the folding of hPyA1.

  20. The basis of clinical tribalism, hierarchy and stereotyping: a laboratory-controlled teamwork experiment

    OpenAIRE

    Braithwaite, Jeffrey; Clay-Williams, Robyn; VECELLIO, ELIA; Marks, Danielle; Hooper, Tamara; Westbrook, Mary; Westbrook, Johanna; Blakely, Brette; Ludlow, Kristiana

    2016-01-01

    Objectives To examine the basis of multidisciplinary teamwork. In real-world healthcare settings, clinicians often cluster in profession-based tribal silos, form hierarchies and exhibit stereotypical behaviours. It is not clear whether these social structures are more a product of inherent characteristics of the individuals or groups comprising the professions, or attributable to a greater extent to workplace factors. Setting Controlled laboratory environment with well-appointed, quiet rooms ...