WorldWideScience

Sample records for unified treatment approach

  1. A unifying probabilistic Bayesian approach to derive electron density from MRI for radiation therapy treatment planning

    International Nuclear Information System (INIS)

    Gudur, Madhu Sudhan Reddy; Hara, Wendy; Le, Quynh-Thu; Wang, Lei; Xing, Lei; Li, Ruijiang

    2014-01-01

    MRI significantly improves the accuracy and reliability of target delineation in radiation therapy for certain tumors due to its superior soft tissue contrast compared to CT. A treatment planning process with MRI as the sole imaging modality will eliminate systematic CT/MRI co-registration errors, reduce cost and radiation exposure, and simplify clinical workflow. However, MRI lacks the key electron density information necessary for accurate dose calculation and generating reference images for patient setup. The purpose of this work is to develop a unifying method to derive electron density from standard T1-weighted MRI. We propose to combine both intensity and geometry information into a unifying probabilistic Bayesian framework for electron density mapping. For each voxel, we compute two conditional probability density functions (PDFs) of electron density given its: (1) T1-weighted MRI intensity, and (2) geometry in a reference anatomy, obtained by deformable image registration between the MRI of the atlas and test patient. The two conditional PDFs containing intensity and geometry information are combined into a unifying posterior PDF, whose mean value corresponds to the optimal electron density value under the mean-square error criterion. We evaluated the algorithm’s accuracy of electron density mapping and its ability to detect bone in the head for eight patients, using an additional patient as the atlas or template. Mean absolute HU error between the estimated and true CT, as well as receiver operating characteristics for bone detection (HU > 200) were calculated. The performance was compared with a global intensity approach based on T1 and no density correction (set whole head to water). The proposed technique significantly reduced the errors in electron density estimation, with a mean absolute HU error of 126, compared with 139 for deformable registration (p = 2  ×  10 −4 ), 283 for the intensity approach (p = 2  ×  10 −6 ) and 282

  2. Cognitive-behavior therapy for problem gambling: a critique of current treatments and proposed new unified approach.

    Science.gov (United States)

    Tolchard, Barry

    2017-06-01

    There is evidence supporting the use of cognitive-behavioral therapy (CBT) in the treatment of problem gambling. Despite this, little is known about how CBT works and which particular approach is most effective. This paper aims to synthesize the evidence for current CBT and propose a more unified approach to treatment. A literature review and narrative synthesis of the current research evidence of CBT for the treatment of problem gambling was conducted, focusing on the underlying mechanisms within the treatment approach. Several CBT approaches were critiqued. These can be divided into forms of exposure therapy (including aversion techniques, systematic desensitization and other behavioral experiments) those focusing on cognitive restructuring techniques (such as reinforcement of nongambling activity, use of diaries, motivational enhancement and audio-playback techniques and third wave techniques including mindfulness. Findings, in relation to the treatment actions, from this synthesis are reported. The debate surrounding the treatment of problem gambling has been conducted as an either/or rather than a both/and discourse. This paper proposes a new, unified approach to the treatment of problem gambling that incorporates the best elements of both exposure and cognitive restructuring techniques, alongside the use of techniques borrowed from mindfulness and other CBT approaches.

  3. Unified approach to dense matter

    International Nuclear Information System (INIS)

    Park, Byung-Yoon; Lee, Hee-Jung; Vento, Vicente; Kim, Joon-Il; Min, Dong-Pil; Rho, Mannque

    2005-01-01

    We apply the Skyrme model to dense hadronic matter, which provides a unified approach to high density, valid in the large N c limit. In our picture, dense hadronic matter is described by the classical soliton configuration with minimum energy for the given baryon number density. By incorporating the meson fluctuations on such ground state we obtain an effective Lagrangian for meson dynamics in a dense medium. Our starting point has been the Skyrme model defined in terms of pions, thereafter we have extended and improved the model by incorporating other degrees of freedom such as dilaton, kaons and vector mesons

  4. A unified approach to the Darwin approximation

    International Nuclear Information System (INIS)

    Krause, Todd B.; Apte, A.; Morrison, P. J.

    2007-01-01

    There are two basic approaches to the Darwin approximation. The first involves solving the Maxwell equations in Coulomb gauge and then approximating the vector potential to remove retardation effects. The second approach approximates the Coulomb gauge equations themselves, then solves these exactly for the vector potential. There is no a priori reason that these should result in the same approximation. Here, the equivalence of these two approaches is investigated and a unified framework is provided in which to view the Darwin approximation. Darwin's original treatment is variational in nature, but subsequent applications of his ideas in the context of Vlasov's theory are not. We present here action principles for the Darwin approximation in the Vlasov context, and this serves as a consistency check on the use of the approximation in this setting

  5. Unified theory in the worldline approach

    Directory of Open Access Journals (Sweden)

    James P. Edwards

    2015-11-01

    Full Text Available We explore unified field theories based on the gauge groups SU(5 and SO(10 using the worldline approach for chiral fermions with a Wilson loop coupling to a background gauge field. Representing path ordering and chiral projection operators with functional integrals has previously reproduced the sum over the chiralities and representations of standard model particles in a compact way. This paper shows that for SU(5 the 5¯ and 10 representations – into which the Georgi–Glashow model places the left-handed fermionic content of the standard model – appear naturally and with the familiar chirality. We carry out the same analysis for flipped SU(5 and uncover a link to SO(10 unified theory. We pursue this by exploring the SO(10 theory in the same framework, the less established unified theory based on SU(6 and briefly consider the Pati–Salam model using SU(4×SU(2×SU(2.

  6. Filament Winding. A Unified Approach

    NARCIS (Netherlands)

    Koussios, S.

    2004-01-01

    In this dissertation we have presented an overview and comprehensive treatment of several facets of the filament winding process. With the concepts of differential geometry and the theory of thin anisotropic shells of revolution, a parametric shape generator has been formulated for the design

  7. Location theory a unified approach

    CERN Document Server

    Nickel, Stefan

    2006-01-01

    Although modern location theory is now more than 90 years old, the focus of researchers in this area has been mainly problem oriented. However, a common theory, which keeps the essential characteristics of classical location models, is still missing.This monograph addresses this issue. A flexible location problem called the Ordered Median Problem (OMP) is introduced. For all three main subareas of location theory (continuous, network and discrete location) structural properties of the OMP are presented and solution approaches provided. Numerous illustrations and examples help the reader to bec

  8. SU-G-JeP2-02: A Unifying Multi-Atlas Approach to Electron Density Mapping Using Multi-Parametric MRI for Radiation Treatment Planning

    Energy Technology Data Exchange (ETDEWEB)

    Ren, S [Stanford University, Stanford, CA (United States); Tianjin University, Tianjin (China); Hara, W; Le, Q; Wang, L; Xing, L; Li, R [Stanford University, Stanford, CA (United States)

    2016-06-15

    Purpose: MRI has a number of advantages over CT as a primary modality for radiation treatment planning (RTP). However, one key bottleneck problem still remains, which is the lack of electron density information in MRI. In the work, a reliable method to map electron density is developed by leveraging the differential contrast of multi-parametric MRI. Methods: We propose a probabilistic Bayesian approach for electron density mapping based on T1 and T2-weighted MRI, using multiple patients as atlases. For each voxel, we compute two conditional probabilities: (1) electron density given its image intensity on T1 and T2-weighted MR images, and (2) electron density given its geometric location in a reference anatomy. The two sources of information (image intensity and spatial location) are combined into a unifying posterior probability density function using the Bayesian formalism. The mean value of the posterior probability density function provides the estimated electron density. Results: We evaluated the method on 10 head and neck patients and performed leave-one-out cross validation (9 patients as atlases and remaining 1 as test). The proposed method significantly reduced the errors in electron density estimation, with a mean absolute HU error of 138, compared with 193 for the T1-weighted intensity approach and 261 without density correction. For bone detection (HU>200), the proposed method had an accuracy of 84% and a sensitivity of 73% at specificity of 90% (AUC = 87%). In comparison, the AUC for bone detection is 73% and 50% using the intensity approach and without density correction, respectively. Conclusion: The proposed unifying method provides accurate electron density estimation and bone detection based on multi-parametric MRI of the head with highly heterogeneous anatomy. This could allow for accurate dose calculation and reference image generation for patient setup in MRI-based radiation treatment planning.

  9. SU-G-JeP2-02: A Unifying Multi-Atlas Approach to Electron Density Mapping Using Multi-Parametric MRI for Radiation Treatment Planning

    International Nuclear Information System (INIS)

    Ren, S; Hara, W; Le, Q; Wang, L; Xing, L; Li, R

    2016-01-01

    Purpose: MRI has a number of advantages over CT as a primary modality for radiation treatment planning (RTP). However, one key bottleneck problem still remains, which is the lack of electron density information in MRI. In the work, a reliable method to map electron density is developed by leveraging the differential contrast of multi-parametric MRI. Methods: We propose a probabilistic Bayesian approach for electron density mapping based on T1 and T2-weighted MRI, using multiple patients as atlases. For each voxel, we compute two conditional probabilities: (1) electron density given its image intensity on T1 and T2-weighted MR images, and (2) electron density given its geometric location in a reference anatomy. The two sources of information (image intensity and spatial location) are combined into a unifying posterior probability density function using the Bayesian formalism. The mean value of the posterior probability density function provides the estimated electron density. Results: We evaluated the method on 10 head and neck patients and performed leave-one-out cross validation (9 patients as atlases and remaining 1 as test). The proposed method significantly reduced the errors in electron density estimation, with a mean absolute HU error of 138, compared with 193 for the T1-weighted intensity approach and 261 without density correction. For bone detection (HU>200), the proposed method had an accuracy of 84% and a sensitivity of 73% at specificity of 90% (AUC = 87%). In comparison, the AUC for bone detection is 73% and 50% using the intensity approach and without density correction, respectively. Conclusion: The proposed unifying method provides accurate electron density estimation and bone detection based on multi-parametric MRI of the head with highly heterogeneous anatomy. This could allow for accurate dose calculation and reference image generation for patient setup in MRI-based radiation treatment planning.

  10. Unified Approach in the DSS Development Process

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The structure of today's decision support environment become very complex due to new generation of Business Intelligence applications and technologies like Data Warehouse, OLAP (On Line Analytical Processing and Data Mining. In this respect DSS development process are not simple and needs an adequate methodology or framework able to manage different tools and platforms to achieve manager's requirements. The DSS development process must be view like a unified and iterative set of activities and operations. The new techniques based on Unified Process (UP methodology and UML (Unified Modeling Language it seems to be appropriate for DSS development using prototyping and RAD (Rapid Application Development techniques. In this paper we present a conceptual framework for development and integrate Decision Support Systems using Unified Process Methodology and UML.

  11. Unified treatment of the luminosity distance in cosmology

    International Nuclear Information System (INIS)

    Yoo, Jaiyul; Scaccabarozzi, Fulvio

    2016-01-01

    Comparing the luminosity distance measurements to its theoretical predictions is one of the cornerstones in establishing the modern cosmology. However, as shown in Biern and Yoo, its theoretical predictions in literature are often plagued with infrared divergences and gauge-dependences. This trend calls into question the sanity of the methods used to derive the luminosity distance. Here we critically investigate four different methods—the geometric approach, the Sachs approach, the Jacobi mapping approach, and the geodesic light cone (GLC) approach to modeling the luminosity distance, and we present a unified treatment of such methods, facilitating the comparison among the methods and checking their sanity. All of these four methods, if exercised properly, can be used to reproduce the correct description of the luminosity distance.

  12. Unified treatment of the luminosity distance in cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jaiyul; Scaccabarozzi, Fulvio, E-mail: jyoo@physik.uzh.ch, E-mail: fulvio@physik.uzh.ch [Center for Theoretical Astrophysics and Cosmology, Institute for Computational Science, University of Zürich, Zürich (Switzerland)

    2016-09-01

    Comparing the luminosity distance measurements to its theoretical predictions is one of the cornerstones in establishing the modern cosmology. However, as shown in Biern and Yoo, its theoretical predictions in literature are often plagued with infrared divergences and gauge-dependences. This trend calls into question the sanity of the methods used to derive the luminosity distance. Here we critically investigate four different methods—the geometric approach, the Sachs approach, the Jacobi mapping approach, and the geodesic light cone (GLC) approach to modeling the luminosity distance, and we present a unified treatment of such methods, facilitating the comparison among the methods and checking their sanity. All of these four methods, if exercised properly, can be used to reproduce the correct description of the luminosity distance.

  13. Top-down approach to unified supergravity models

    International Nuclear Information System (INIS)

    Hempfling, R.

    1994-03-01

    We introduce a new approach for studying unified supergravity models. In this approach all the parameters of the grand unified theory (GUT) are fixed by imposing the corresponding number of low energy observables. This determines the remaining particle spectrum whose dependence on the low energy observables can now be investigated. We also include some SUSY threshold corrections that have previously been neglected. In particular the SUSY threshold corrections to the fermion masses can have a significant impact on the Yukawa coupling unification. (orig.)

  14. The group manifold approach to unified gravity

    International Nuclear Information System (INIS)

    Regge, T.

    1984-01-01

    These lectures start with a synopsis of historical results in the construction of unified theories of gravity. The author keeps some mathematical rigour throughout the lectures. He gives a provisional description of supermanifolds and a set of formal rules intended to manipulate superforms or supermanifolds. Super Lie groups are discussed as well as the dimensional reduction of gravity theories, the Kaluza-Klein theory. A formal introduction of supersymmetry is given. (Auth.)

  15. Mechanical systems a unified approach to vibrations and controls

    CERN Document Server

    Gans, Roger F

    2015-01-01

    This essential textbook covers analysis and control of engineering mechanisms, which include almost any apparatus with moving parts used in daily life, from musical instruments to robots. The text  presents both vibrations and controls with considerable breadth and depth using a unified notation. It strikes a nice balance between the analytical and the practical.  This text contains enough material for a two semester sequence, but it can also be used in a single semester course combining the two topics. Mechanical Systems: A Unified Approach to Vibrations and Controls presents a common notation and approach to these closely related areas. Examples from the both vibrations and controls components are integrated throughout this text. This book also: ·         Presents a unified approach to vibrations and controls, including an excellent diagram that simultaneously discusses embedding classical vibrations (mechanical systems) in a discussion of models, inverse models, and open and closed loop control ...

  16. Argumentation and Inference: A Unified Approach

    Directory of Open Access Journals (Sweden)

    Christophe Fouqueré

    2013-12-01

    Full Text Available We propose in this paper to use Ludics as a unified framework for the analysis of dialogue and the reasoning system. Not only is Ludics a logical theory, but it may also be built by means of concepts of game theory. We first present the main concepts of Ludics. A design is an abstraction and a generalization of the concept of proof. Interaction between designs is equivalent to cut elimination or modus ponens in logical theories. It appears to be a natural means for representing dialogues and also for reasoning. A design is a set of sequences of alternate actions, similar to a move in game theory. We apply Ludics to argumentative dialogues. We discuss how to model the speech acts of argumentative dialogues in terms of dialogue acts. A dialogue act is given by a Ludics action together with the expression that reveals the action in a turn of speech. We show also how arguments may be stored in a commitment state used for reasoning. Finally we revisit an example of juridical dialogue that has been analyzed by Prakken in a different framework.

  17. a Unified Matrix Polynomial Approach to Modal Identification

    Science.gov (United States)

    Allemang, R. J.; Brown, D. L.

    1998-04-01

    One important current focus of modal identification is a reformulation of modal parameter estimation algorithms into a single, consistent mathematical formulation with a corresponding set of definitions and unifying concepts. Particularly, a matrix polynomial approach is used to unify the presentation with respect to current algorithms such as the least-squares complex exponential (LSCE), the polyreference time domain (PTD), Ibrahim time domain (ITD), eigensystem realization algorithm (ERA), rational fraction polynomial (RFP), polyreference frequency domain (PFD) and the complex mode indication function (CMIF) methods. Using this unified matrix polynomial approach (UMPA) allows a discussion of the similarities and differences of the commonly used methods. the use of least squares (LS), total least squares (TLS), double least squares (DLS) and singular value decomposition (SVD) methods is discussed in order to take advantage of redundant measurement data. Eigenvalue and SVD transformation methods are utilized to reduce the effective size of the resulting eigenvalue-eigenvector problem as well.

  18. A Unified Approach to Modeling and Programming

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann; Møller-Pedersen, Birger

    2010-01-01

    of this paper is to go back to the future and get inspiration from SIMULA and propose a unied approach. In addition to reintroducing the contributions of SIMULA and the Scandinavian approach to object-oriented programming, we do this by discussing a number of issues in modeling and programming and argue3 why we......SIMULA was a language for modeling and programming and provided a unied approach to modeling and programming in contrast to methodologies based on structured analysis and design. The current development seems to be going in the direction of separation of modeling and programming. The goal...

  19. A unifying approach to existence of Nash equilibria

    NARCIS (Netherlands)

    Balder, E.J.

    1997-01-01

    An approach initiated in [4] is shown to unify results about the existence of (i) Nash equilibria in games with at most countably many players, (ii) Cournot-Nash equilibrium distributions for large, anonymous games, and (iii) Nash equilibria (both mixed and pure) for continuum games. A new, central

  20. Mechanics of composite materials: Unified micromechanical approach

    International Nuclear Information System (INIS)

    Aboundi, J.

    1991-01-01

    Although many books have been written on the mechanics of composite materials, only a vew few have been devoted almost exclusively to the micromechanics aspects. The present monograph is devoted primarily to the micromechanics of fiber and particle reinforced composites with some additional treatment of laminates as well. Thus, this book would probably be more suitable as a reference book than a textbook

  1. A unified innovation approach to emerging markets

    DEFF Research Database (Denmark)

    Agarwal, Nivedita; Brem, Alexander; Grottke, Michael

    2014-01-01

    for emerging markets (2) and establish relative importance of key factors for product managers while conceptualizing a new product for emerging markets. In the first part, the study assembles the list of characteristics from the selected innovation theories revolving around emerging markets. Subsequently...... the overarching innovation approach for emerging markets and provides a common definition for a product considered relevant for emerging market. The results show high prioritization given to cost effective, easy to use and problem centric as compared to the sustainability, no-frills, resourceful, breakthrough...... and fast-to-market factors by product managers. However, the paper acknowledges that the prioritization results are subject to change given different motivation behind the various theories. Finally the paper proposes that, the eight key factors required factors to “play in” emerging markets would...

  2. A unified approach of catastrophic events

    Directory of Open Access Journals (Sweden)

    S. Nikolopoulos

    2004-01-01

    Full Text Available Although there is an accumulated charge of theoretical, computational, and numerical work, like catastrophe theory, bifurcation theory, stochastic and deterministic chaos theory, there is an important feeling that these matters do not completely cover the physics of real catastrophic events. Recent studies have suggested that a large variety of complex processes, including earthquakes, heartbeats, and neuronal dynamics, exhibits statistical similarities. Here we are studying in terms of complexity and non linear techniques whether isomorphic signatures emerged indicating the transition from the normal state to the both geological and biological shocks. In the last 15 years, the study of Complex Systems has emerged as a recognized field in its own right, although a good definition of what a complex system is, actually is eluded. A basic reason for our interest in complexity is the striking similarity in behaviour close to irreversible phase transitions among systems that are otherwise quite different in nature. It is by now recognized that the pre-seismic electromagnetic time-series contain valuable information about the earthquake preparation process, which cannot be extracted without the use of important computational power, probably in connection with computer Algebra techniques. This paper presents an analysis, the aim of which is to indicate the approach of the global instability in the pre-focal area. Non-linear characteristics are studied by applying two techniques, namely the Correlation Dimension Estimation and the Approximate Entropy. These two non-linear techniques present coherent conclusions, and could cooperate with an independent fractal spectral analysis to provide a detection concerning the emergence of the nucleation phase of the impending catastrophic event. In the context of similar mathematical background, it would be interesting to augment this description of pre-seismic electromagnetic anomalies in order to cover biological

  3. DiPS: A Unifying Approach for developing System Software

    OpenAIRE

    Michiels, Sam; Matthijs, Frank; Walravens, Dirk; Verbaeten, Pierre

    2002-01-01

    In this paper we unify three essential features for flexible system software: a component oriented approach, self-adaptation and separation of concerns.We propose DiPS (Distrinet Protocol Stack), a component framework, which offers components, an anonymous interaction model and connectors to handle non-functional aspects such as concurrency. DiPS has effectively been used in industrial protocol stacks and device drivers.

  4. A unified treatment of kinetic effects in a tokamak pedestal

    International Nuclear Information System (INIS)

    Catto, Peter J; Landreman, Matt; Kagan, Grigory; Pusztai, Istvan

    2011-01-01

    We consider the effects of a finite pedestal radial electric field on ion orbits using a unified approach. We then employ these modified orbit results to retain finite E x B drift departures from flux surfaces in an improved drift-kinetic equation. The procedure allows us to make a clear distinction between transit averages and flux surface averages when solving this kinetic equation. The technique outlined here is intended to clarify and unify recent evaluations of the banana regime decrease and plateau regime alterations in the ion heat diffusivity; the reduction and possible reversal of the poloidal flow in the banana regime, and its augmentation in the plateau regime; the increase in the bootstrap current; and the enhancement of the residual zonal flow regulation of turbulence.

  5. Engineering system dynamics a unified graph-centered approach

    CERN Document Server

    Brown, Forbes T

    2006-01-01

    For today's students, learning to model the dynamics of complex systems is increasingly important across nearly all engineering disciplines. First published in 2001, Forbes T. Brown's Engineering System Dynamics: A Unified Graph-Centered Approach introduced students to a unique and highly successful approach to modeling system dynamics using bond graphs. Updated with nearly one-third new material, this second edition expands this approach to an even broader range of topics. What's New in the Second Edition? In addition to new material, this edition was restructured to build students' competence in traditional linear mathematical methods before they have gone too far into the modeling that still plays a pivotal role. New topics include magnetic circuits and motors including simulation with magnetic hysteresis; extensive new material on the modeling, analysis, and simulation of distributed-parameter systems; kinetic energy in thermodynamic systems; and Lagrangian and Hamiltonian methods. MATLAB(R) figures promi...

  6. A Unified Approach to Model-Based Planning and Execution

    Science.gov (United States)

    Muscettola, Nicola; Dorais, Gregory A.; Fry, Chuck; Levinson, Richard; Plaunt, Christian; Norvig, Peter (Technical Monitor)

    2000-01-01

    Writing autonomous software is complex, requiring the coordination of functionally and technologically diverse software modules. System and mission engineers must rely on specialists familiar with the different software modules to translate requirements into application software. Also, each module often encodes the same requirement in different forms. The results are high costs and reduced reliability due to the difficulty of tracking discrepancies in these encodings. In this paper we describe a unified approach to planning and execution that we believe provides a unified representational and computational framework for an autonomous agent. We identify the four main components whose interplay provides the basis for the agent's autonomous behavior: the domain model, the plan database, the plan running module, and the planner modules. This representational and problem solving approach can be applied at all levels of the architecture of a complex agent, such as Remote Agent. In the rest of the paper we briefly describe the Remote Agent architecture. The new agent architecture proposed here aims at achieving the full Remote Agent functionality. We then give the fundamental ideas behind the new agent architecture and point out some implication of the structure of the architecture, mainly in the area of reactivity and interaction between reactive and deliberative decision making. We conclude with related work and current status.

  7. Cloud Computing - A Unified Approach for Surveillance Issues

    Science.gov (United States)

    Rachana, C. R.; Banu, Reshma, Dr.; Ahammed, G. F. Ali, Dr.; Parameshachari, B. D., Dr.

    2017-08-01

    Cloud computing describes highly scalable resources provided as an external service via the Internet on a basis of pay-per-use. From the economic point of view, the main attractiveness of cloud computing is that users only use what they need, and only pay for what they actually use. Resources are available for access from the cloud at any time, and from any location through networks. Cloud computing is gradually replacing the traditional Information Technology Infrastructure. Securing data is one of the leading concerns and biggest issue for cloud computing. Privacy of information is always a crucial pointespecially when an individual’s personalinformation or sensitive information is beingstored in the organization. It is indeed true that today; cloud authorization systems are notrobust enough. This paper presents a unified approach for analyzing the various security issues and techniques to overcome the challenges in the cloud environment.

  8. Unified treatment of the classical and quantum mechanics

    International Nuclear Information System (INIS)

    Shirokov, Yu.M.

    1979-01-01

    Classical and Quantum Mechanics are unified in the sense that almost all axioms of both mechanics are identical. The only distinction is the explicit form of one algebraic identity. The unified theory is applied to scattering problem. (Z.M.)

  9. A unified approach for the spatial enhancement of sound

    Science.gov (United States)

    Choi, Joung-Woo; Jang, Ji-Ho; Kim, Yang-Hann

    2005-09-01

    This paper aims to control the sound field spatially, so that the desired or target acoustic variable is enhanced within a zone where a listener is located. This is somewhat analogous to having manipulators that can draw sounds in any place. This also means that one can somehow see the controlled shape of sound in frequency or in real time. The former assures its practical applicability, for example, listening zone control for music. The latter provides a mean of analyzing sound field. With all these regards, a unified approach is proposed that can enhance selected acoustic variables using multiple sources. Three kinds of acoustic variables that have to do with magnitude and direction of sound field are formulated and enhanced. The first one, which has to do with the spatial control of acoustic potential energy, enables one to make a zone of loud sound over an area. Otherwise, one can control directional characteristic of sound field by controlling directional energy density, or one can enhance the magnitude and direction of sound at the same time by controlling acoustic intensity. Throughout various examples, it is shown that these acoustic variables can be controlled successfully by the proposed approach.

  10. Unified Approach to the Biomechanics of Dental Implantology

    Science.gov (United States)

    Grenoble, D. E.; Knoell, A. C.

    1973-01-01

    The human need for safe and effective dental implants is well-recognized. Although many implant designs have been tested and are in use today, a large number have resulted in clinical failure. These failures appear to be due to biomechanical effects, as well as biocompatibility and surgical factors. A unified approach is proposed using multidisciplinary systems technology, for the study of the biomechanical interactions between dental implants and host tissues. The approach progresses from biomechanical modeling and analysis, supported by experimental investigations, through implant design development, clinical verification, and education of the dental practitioner. The result of the biomechanical modeling, analysis, and experimental phases would be the development of scientific design criteria for implants. Implant designs meeting these criteria would be generated, fabricated, and tested in animals. After design acceptance, these implants would be tested in humans, using efficient and safe surgical and restorative procedures. Finally, educational media and instructional courses would be developed for training dental practitioners in the use of the resulting implants.

  11. Unified communications

    OpenAIRE

    Kravos, Urban

    2011-01-01

    In the modern business world, communication are becoming more and more complex. As a solution to this problem unified communications occurred. Using a single communication approach unified communications are the integration of various communication technologies (eg, telephony, unified messaging, audio, video and web conferencing and collaboration tools). Unified Messaging, which represents only part of the unified communications means the integration of different non real time communication t...

  12. Adhesion at Entangled Polymer Interfaces: A Unified Approach..

    Science.gov (United States)

    Wool, Richard

    2006-03-01

    A unified theory of fracture of polymer interfaces was developed which was based on the Rigidity Percolation model of fracture [R.P. Wool, J.Polym.Sci. Part A: Polym Phys., 43,168(2005)]. The polymer fractured critically when the normalized entanglement density p, approached the percolation threshold pc. The fracture energy was found to be G1c ˜ [p-pc]. When applied to interfaces of width X, containing an areal density σ of chains, each contributing L chain entanglements, the percolation term p ˜ σL/X and the percolation threshold was related to σc, Lc, or Xc. For welding of A/A symmetric interfaces, p = σL/X, and pc Lc/M 0, such that when σ/X ˜1/M for randomly distributed chain ends, p˜L ˜ (t/M)^1/2, G/G* = (t/τ*)^1/2, where the weld time τ* ˜ M. When the chain ends are segregated to the surface, σ is constant with time and G/G* = [t/τ*]^1/4. For sub-Tg welding, there exists a surface mobile layer (due to the critical Lindemann Atom fraction) of depth X ˜ 1/δT^ν such that G ˜ δT-2ν, where the critical exponent v = 0.8. For incompatible A/B interfaces of Helfand width d, normalized width w = d/Rge, and entanglement density Nent ˜ d/Le, p ˜ d such that, G1c ˜ [d-dc], G1c ˜ [w-1], and G ˜ [Nent-Nc]. For incompatible A/B interfaces reinforced by an areal density σ of compatibilizer chains, L and X are constant, p ˜ σ, pc ˜σc, such that G1c ˜ [σ-σc], which is in excellent agreement with experimental data.

  13. Modeling of hydrodynamic cavitation reactors: a unified approach

    NARCIS (Netherlands)

    Moholkar, V.S.; Pandit, A.B.

    2001-01-01

    An attempt has been made to present a unified theoretical model for the cavitating flow in a hydrodynamic cavitation reactor using the nonlinear continuum mixture model for two-phase flow as the basis. This model has been used to describe the radial motion of bubble in the cavitating flow in two

  14. Unified Approach to Universal Cloning and Phase-Covariant Cloning

    OpenAIRE

    Hu, Jia-Zhong; Yu, Zong-Wen; Wang, Xiang-Bin

    2008-01-01

    We analyze the problem of approximate quantum cloning when the quantum state is between two latitudes on the Bloch's sphere. We present an analytical formula for the optimized 1-to-2 cloning. The formula unifies the universal quantum cloning (UQCM) and the phase covariant quantum cloning.

  15. Estimating High-Frequency Based (Co-) Variances: A Unified Approach

    DEFF Research Database (Denmark)

    Voev, Valeri; Nolte, Ingmar

    We propose a unified framework for estimating integrated variances and covariances based on simple OLS regressions, allowing for a general market microstructure noise specification. We show that our estimators can outperform, in terms of the root mean squared error criterion, the most recent...... and commonly applied estimators, such as the realized kernels of Barndorff-Nielsen, Hansen, Lunde & Shephard (2006), the two-scales realized variance of Zhang, Mykland & Aït-Sahalia (2005), the Hayashi & Yoshida (2005) covariance estimator, and the realized variance and covariance with the optimal sampling...

  16. Concept of Draft International Standard for a Unified Approach to Space Program Quality Assurance

    Science.gov (United States)

    Stryzhak, Y.; Vasilina, V.; Kurbatov, V.

    2002-01-01

    For want of the unified approach to guaranteed space project and product quality assurance, implementation of many international space programs has become a challenge. Globalization of aerospace industry and participation of various international ventures with diverse quality assurance requirements in big international space programs requires for urgent generation of unified international standards related to this field. To ensure successful fulfillment of space missions, aerospace companies should design and process reliable and safe products with properties complying or bettering User's (or Customer's) requirements. Quality of the products designed or processed by subcontractors (or other suppliers) should also be in compliance with the main user (customer)'s requirements. Implementation of this involved set of unified requirements will be made possible by creating and approving a system (series) of international standards under a generic title Space Product Quality Assurance based on a system consensus principle. Conceptual features of the baseline standard in this system (series) should comprise: - Procedures for ISO 9000, CEN and ECSS requirements adaptation and introduction into space product creation, design, manufacture, testing and operation; - Procedures for quality assurance at initial (design) phases of space programs, with a decision on the end product made based on the principle of independence; - Procedures to arrange incoming inspection of products delivered by subcontractors (including testing, audit of supplier's procedures, review of supplier's documentation), and space product certification; - Procedures to identify materials and primary products applied; - Procedures for quality system audit at the component part, primary product and materials supplier facilities; - Unified procedures to form a list of basic performances to be under configuration management; - Unified procedures to form a list of critical space product components, and unified

  17. Exponential stability for formation control systems with generalized controllers: A unified approach

    NARCIS (Netherlands)

    Sun, Zhiyong; Mou, Shaoshuai; Anderson, Brian D.O.; Cao, Ming

    2016-01-01

    This paper discusses generalized controllers for distance-based rigid formation shape stabilization and aims to provide a unified approach for the convergence analysis. We consider two types of formation control systems according to different characterizations of target formations: minimally rigid

  18. A unifying energy-based approach to stability of power grids with market dynamics

    NARCIS (Netherlands)

    Stegink, Tjerk; De Persis, Claudio; van der Schaft, Arjan

    2017-01-01

    In this paper a unifying energy-based approach is provided to the modeling and stability analysis of power systems coupled with market dynamics. We consider a standard model of the power network with a third-order model for the synchronous generators involving voltage dynamics. By applying the

  19. A unified approach for impulsive lag synchronization of chaotic systems with time delay

    International Nuclear Information System (INIS)

    Li Chuandong; Liao Xiaofeng; Zhang Rong

    2005-01-01

    In this paper, we propose a unified approach for impulsive lag-synchronization of a class of chaotic systems with time delay by employing the stability theory of impulsive delayed differential equations. Three well-known delayed chaotic systems are presented to illustrate our results. Also, the estimates of the stable regions for these systems are given, respectively

  20. Structure versus level: A unified approach to campaign evaluation

    DEFF Research Database (Denmark)

    Scholderer, Joachim; Grunert, Klaus G.

    2001-01-01

    Based on a modified version of the theory of planned behavior (Ajzen, 1985), a general model for the evaluation of social interventions is developed. Whilst common practice defines campaign success in terms of absolute levels of the target variables, the present approach stresses changes...

  1. Taxes, subsidies and unemployment - a unified optimization approach

    Directory of Open Access Journals (Sweden)

    Erik Bajalinov

    2010-12-01

    Full Text Available Like a linear programming (LP problem, linear-fractional programming (LFP problem can be usefully applied in a wide range of real-world applications. In the last few decades a lot of research papers and monographs were published throughout the world where authors (mainly mathematicians investigated different theoretical and algorithmic aspects of LFP problems in various forms. In this paper we consider these two approaches to optimization (based on linear and linear-fractional objective functions on the same feasible set, compare results they lead to and give interpretation in terms of taxes, subsidies and manpower requirement. We show that in certain cases both approaches are closely connected with one another and may be fruitfully utilized simultaneously.

  2. Statistical analysis of questionnaires a unified approach based on R and Stata

    CERN Document Server

    Bartolucci, Francesco; Gnaldi, Michela

    2015-01-01

    Statistical Analysis of Questionnaires: A Unified Approach Based on R and Stata presents special statistical methods for analyzing data collected by questionnaires. The book takes an applied approach to testing and measurement tasks, mirroring the growing use of statistical methods and software in education, psychology, sociology, and other fields. It is suitable for graduate students in applied statistics and psychometrics and practitioners in education, health, and marketing.The book covers the foundations of classical test theory (CTT), test reliability, va

  3. Monitoring the shorebirds of North America: Towards a unified approach

    Science.gov (United States)

    Skagen, S.K.; Bart, J.; Andres, B.; Brown, S.; Donaldson, G.; Harrington, B.; Johnston, V.; Jones, S.L.; Morrison, R.I.G.

    2003-01-01

    The Program for Regional and International Shorebird Monitoring (PRISM) has recently developed a single blueprint for monitoring shorebirds in Canada and the United States in response to needs identified by recent shorebird conservation plans. The goals of PRISM are to: (1) estimate the size of breeding populations of 74 shorebird taxa in North America; (2) describe the distribution, abundance, and habitat relationships for these taxa; (3) monitor trends in shorebird population size; (4) monitor shorebird numbers at stopover locations, and; (5) assist local managers in meeting their shorebird conservation goals. The initial focus has been on developing methods to estimate trends in population size. A three-part approach for estimating trends includes: (1) breeding surveys in arctic, boreal, and temperate regions, (2) migration surveys, and (3) wintering surveys.

  4. A unified approach to failure assessment of engineering structures

    International Nuclear Information System (INIS)

    Harrison, R.P.

    1977-01-01

    A codified procedure for the failure assessment of engineering structures is presented which has as its basis the two criteria approach of Dowling and Townley (Int. J. Press. Vessels and Piping; 3:77 (1975)) and the Bilby, Cottrell and Swinden (Proc. R. Soc.; A272:304 (1963)) and Dugdale (J. Mech. Phys. Sol.; 8:100 (1960)) model of yielding ahead of a crack tip. The procedure consists of independently assessing the risk of failure (a) under linear elastic conditions only and (b) under plastic collapse conditions only. These two limiting criteria are then plotted as a co-ordinate point on a Failure Assessment Diagram. From this a measure of the degree of safety of the structure can be obtained. As examples, several of the HSST vessel tests are used to indicate the simplicity and versatility of the procedure. It is shown how maximum allowable pressures or defect sizes can be obtained and how safety factors can be readily incorporated on any of the parameters used in the assessment. It is also demonstrated how helpful the procedure is in designing not only working structures, but also structures that are to be used for testing. (author)

  5. A Unified Approach for Reporting ARM Measurement Uncertainties Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Campos, E [Argonne National Lab. (ANL), Argonne, IL (United States); Sisterson, Douglas [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-12-01

    : 1) identifying how the uncertainty of individual ARM measurements is currently expressed, 2) identifying a consistent approach to measurement uncertainty, and then 3) reclassifying ARM instrument measurement uncertainties in a common framework.

  6. Unified Approach to Modeling and Simulation of Space Communication Networks and Systems

    Science.gov (United States)

    Barritt, Brian; Bhasin, Kul; Eddy, Wesley; Matthews, Seth

    2010-01-01

    Network simulator software tools are often used to model the behaviors and interactions of applications, protocols, packets, and data links in terrestrial communication networks. Other software tools that model the physics, orbital dynamics, and RF characteristics of space systems have matured to allow for rapid, detailed analysis of space communication links. However, the absence of a unified toolset that integrates the two modeling approaches has encumbered the systems engineers tasked with the design, architecture, and analysis of complex space communication networks and systems. This paper presents the unified approach and describes the motivation, challenges, and our solution - the customization of the network simulator to integrate with astronautical analysis software tools for high-fidelity end-to-end simulation. Keywords space; communication; systems; networking; simulation; modeling; QualNet; STK; integration; space networks

  7. A new and unifying approach to spin dynamics and beam polarization in storage rings

    International Nuclear Information System (INIS)

    Heinemann, K.; Ellison, J.A.

    2014-09-01

    With this paper we extend our studies on polarized beams by distilling tools from the theory of principal bundles. Four major theorems are presented, one which ties invariant fields with the notion of normal form, one which allows one to compare different invariant fields, and two that relate the existence of invariant fields to the existence of certain invariant sets and relations between them. We then apply the theory to the dynamics of spin-1/2 and spin-1 particles and their density matrices describing statistically the particle-spin content of bunches. Our approach thus unifies the spin-vector dynamics from the T-BMT equation with the spin-tensor dynamics and other dynamics. This unifying aspect of our approach relates the examples elegantly and uncovers relations between the various underlying dynamical systems in a transparent way.

  8. Energy-Efficient Distributed Filtering in Sensor Networks: A Unified Switched System Approach.

    Science.gov (United States)

    Zhang, Dan; Shi, Peng; Zhang, Wen-An; Yu, Li

    2016-04-21

    This paper is concerned with the energy-efficient distributed filtering in sensor networks, and a unified switched system approach is proposed to achieve this goal. For the system under study, the measurement is first sampled under nonuniform sampling periods, then the local measurement elements are selected and quantized for transmission. Then, the transmission rate is further reduced to save constrained power in sensors. Based on the switched system approach, a unified model is presented to capture the nonuniform sampling, the measurement size reduction, the transmission rate reduction, the signal quantization, and the measurement missing phenomena. Sufficient conditions are obtained such that the filtering error system is exponentially stable in the mean-square sense with a prescribed H∞ performance level. Both simulation and experiment studies are given to show the effectiveness of the proposed new design technique.

  9. Unified approach for determining the enthalpic fictive temperature of glasses with arbitrary thermal history

    DEFF Research Database (Denmark)

    Guo, Xiaoju; Potuzak, M.; Mauro, J. C.

    2011-01-01

    We propose a unified routine to determine the enthalpic fictive temperature of a glass with arbitrary thermal history under isobaric conditions. The technique is validated both experimentally and numerically using a novel approach for modeling of glass relaxation behavior. The technique is applic......We propose a unified routine to determine the enthalpic fictive temperature of a glass with arbitrary thermal history under isobaric conditions. The technique is validated both experimentally and numerically using a novel approach for modeling of glass relaxation behavior. The technique...... is applicable to glasses of any thermal history, as proved through a series of numerical simulations where the enthalpic fictive temperature is precisely known within the model. Also, we demonstrate that the enthalpic fictive temperature of a glass can be determined at any calorimetric scan rate in excellent...

  10. Unified approach to the study of solid fuel combustion characteristics at high airflow speeds

    Science.gov (United States)

    Vnuchkov, D. A.; Lukashevich, S. V.; Nalivaychenko, D. G.; Zvegintsev, V. I.

    2017-10-01

    The main objective of the research is the development of guidelines for a unified approach to testing the combustion of different solid fuels in gaseous oxidant high-speed flow, so that research outcomes could be presented in a standardized and cohesive form. All the experiments were performed on a special experimental installation designed for quantification of the burning characteristics of different fuels in a wide range of the airflow parameters at the same geometry of the combustion chamber.

  11. A unified Monte Carlo approach to fast neutron cross section data evaluation.

    Energy Technology Data Exchange (ETDEWEB)

    Smith, D.; Nuclear Engineering Division

    2008-03-03

    A unified Monte Carlo (UMC) approach to fast neutron cross section data evaluation that incorporates both model-calculated and experimental information is described. The method is based on applications of Bayes Theorem and the Principle of Maximum Entropy as well as on fundamental definitions from probability theory. This report describes the formalism, discusses various practical considerations, and examines a few numerical examples in some detail.

  12. A unified modeling approach for physical experiment design and optimization in laser driven inertial confinement fusion

    Energy Technology Data Exchange (ETDEWEB)

    Li, Haiyan [Mechatronics Engineering School of Guangdong University of Technology, Guangzhou 510006 (China); Huang, Yunbao, E-mail: Huangyblhy@gmail.com [Mechatronics Engineering School of Guangdong University of Technology, Guangzhou 510006 (China); Jiang, Shaoen, E-mail: Jiangshn@vip.sina.com [Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Jing, Longfei, E-mail: scmyking_2008@163.com [Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China); Tianxuan, Huang; Ding, Yongkun [Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang 621900 (China)

    2015-11-15

    Highlights: • A unified modeling approach for physical experiment design is presented. • Any laser facility can be flexibly defined and included with two scripts. • Complex targets and laser beams can be parametrically modeled for optimization. • Automatically mapping of laser beam energy facilitates targets shape optimization. - Abstract: Physical experiment design and optimization is very essential for laser driven inertial confinement fusion due to the high cost of each shot. However, only limited experiments with simple structure or shape on several laser facilities can be designed and evaluated in available codes, and targets are usually defined by programming, which may lead to it difficult for complex shape target design and optimization on arbitrary laser facilities. A unified modeling approach for physical experiment design and optimization on any laser facilities is presented in this paper. Its core idea includes: (1) any laser facility can be flexibly defined and included with two scripts, (2) complex shape targets and laser beams can be parametrically modeled based on features, (3) an automatically mapping scheme of laser beam energy onto discrete mesh elements of targets enable targets or laser beams be optimized without any additional interactive modeling or programming, and (4) significant computation algorithms are additionally presented to efficiently evaluate radiation symmetry on the target. Finally, examples are demonstrated to validate the significance of such unified modeling approach for physical experiments design and optimization in laser driven inertial confinement fusion.

  13. Unified approach to redshift in cosmological/black hole spacetimes and synchronous frame

    Science.gov (United States)

    Toporensky, A. V.; Zaslavskii, O. B.; Popov, S. B.

    2018-01-01

    Usually, interpretation of redshift in static spacetimes (for example, near black holes) is opposed to that in cosmology. In this methodological note, we show that both explanations are unified in a natural picture. This is achieved if, considering the static spacetime, one (i) makes a transition to a synchronous frame, and (ii) returns to the original frame by means of local Lorentz boost. To reach our goal, we consider a rather general class of spherically symmetric spacetimes. In doing so, we construct frames that generalize the well-known Lemaitre and Painlevé-Gullstand ones and elucidate the relation between them. This helps us to understand, in a unifying approach, how gravitation reveals itself in different branches of general relativity. This framework can be useful for general relativity university courses.

  14. Unified Treatment of a Class of Spherically Symmetric Potentials: Quasi-Exact Solution

    International Nuclear Information System (INIS)

    Baradaran, M.; Panahi, H.

    2016-01-01

    We investigate the Schrödinger equation for a class of spherically symmetric potentials in a simple and unified manner using the Lie algebraic approach within the framework of quasi-exact solvability. We illustrate that all models give rise to the same basic differential equation, which is expressible as an element of the universal enveloping algebra of sl(2). Then, we obtain the general exact solutions of the problem by employing the representation theory of sl(2) Lie algebra.

  15. Randomized controlled trial of false safety behavior elimination therapy: a unified cognitive behavioral treatment for anxiety psychopathology.

    Science.gov (United States)

    Schmidt, Norman B; Buckner, Julia D; Pusser, Andrea; Woolaway-Bickel, Kelly; Preston, Jennifer L; Norr, Aaron

    2012-09-01

    We tested the efficacy of a unified cognitive-behavioral therapy protocol for anxiety disorders. This group treatment protocol, termed false safety behavior elimination therapy (F-SET), is a cognitive-behavioral approach designed for use across various anxiety disorders such as panic disorder (PD), social anxiety disorder (SAD), and generalized anxiety disorder (GAD). F-SET simplifies, as well as broadens, key therapeutic elements of empirically validated treatments for anxiety disorders to allow for easier delivery to heterogeneous groups of patients with anxiety psychopathology. Patients with a primary anxiety disorder diagnosis (N=96) were randomly assigned to F-SET or a wait-list control. Data indicate that F-SET shows good efficacy and durability when delivered to mixed groups of patients with anxieties (i.e., PD, SAD, GAD) by relatively inexperienced clinicians. Findings are discussed in the context of balancing treatment efficacy and clinical utility. Copyright © 2012. Published by Elsevier Ltd.

  16. Modeling of Electromagnetic Fields in Parallel-Plane Structures: A Unified Contour-Integral Approach

    Directory of Open Access Journals (Sweden)

    M. Stumpf

    2017-04-01

    Full Text Available A unified reciprocity-based modeling approach for analyzing electromagnetic fields in dispersive parallel-plane structures of arbitrary shape is described. It is shown that the use of the reciprocity theorem of the time-convolution type leads to a global contour-integral interaction quantity from which novel both time- and frequency-domain numerical schemes can be arrived at. Applications of the numerical method concerning the time-domain radiated interference and susceptibility of parallel-plane structures are discussed and illustrated on numerical examples.

  17. Modeling of annular two-phase flow using a unified CFD approach

    Energy Technology Data Exchange (ETDEWEB)

    Li, Haipeng, E-mail: haipengl@kth.se; Anglart, Henryk, E-mail: henryk@kth.se

    2016-07-15

    Highlights: • Annular two-phase flow has been modeled using a unified CFD approach. • Liquid film was modeled based on a two-dimensional thin film assumption. • Both Eulerian and Lagrangian methods were employed for the gas core flow modeling. - Abstract: A mechanistic model of annular flow with evaporating liquid film has been developed using computational fluid dynamics (CFD). The model is employing a separate solver with two-dimensional conservation equations to predict propagation of a thin boiling liquid film on solid walls. The liquid film model is coupled to a solver of three-dimensional conservation equations describing the gas core, which is assumed to contain a saturated mixture of vapor and liquid droplets. Both the Eulerian–Eulerian and the Eulerian–Lagrangian approach are used to describe the droplet and vapor motion in the gas core. All the major interaction phenomena between the liquid film and the gas core flow have been accounted for, including the liquid film evaporation as well as the droplet deposition and entrainment. The resultant unified framework for annular flow has been applied to the steam-water flow with conditions typical for a Boiling Water Reactor (BWR). The simulation results for the liquid film flow rate show good agreement with the experimental data, with the potential to predict the dryout occurrence based on criteria of critical film thickness or critical film flow rate.

  18. Modeling of annular two-phase flow using a unified CFD approach

    International Nuclear Information System (INIS)

    Li, Haipeng; Anglart, Henryk

    2016-01-01

    Highlights: • Annular two-phase flow has been modeled using a unified CFD approach. • Liquid film was modeled based on a two-dimensional thin film assumption. • Both Eulerian and Lagrangian methods were employed for the gas core flow modeling. - Abstract: A mechanistic model of annular flow with evaporating liquid film has been developed using computational fluid dynamics (CFD). The model is employing a separate solver with two-dimensional conservation equations to predict propagation of a thin boiling liquid film on solid walls. The liquid film model is coupled to a solver of three-dimensional conservation equations describing the gas core, which is assumed to contain a saturated mixture of vapor and liquid droplets. Both the Eulerian–Eulerian and the Eulerian–Lagrangian approach are used to describe the droplet and vapor motion in the gas core. All the major interaction phenomena between the liquid film and the gas core flow have been accounted for, including the liquid film evaporation as well as the droplet deposition and entrainment. The resultant unified framework for annular flow has been applied to the steam-water flow with conditions typical for a Boiling Water Reactor (BWR). The simulation results for the liquid film flow rate show good agreement with the experimental data, with the potential to predict the dryout occurrence based on criteria of critical film thickness or critical film flow rate.

  19. A new approach to homeostatic regulation: towards a unified view of physiological and ecological concepts.

    Directory of Open Access Journals (Sweden)

    Cédric L Meunier

    Full Text Available Stoichiometric homeostasis is the ability of an organism to keep its body chemical composition constant, despite varying inputs. Stoichiometric homeostasis therefore constrains the metabolic needs of consumers which in turn often feed on resources not matching these requirements. In a broader context, homeostasis also relates to the capacity of an organism to maintain other biological parameters (e.g. body temperature at a constant level over ambient environmental variations. Unfortunately, there are discrepancies in the literature and ecological and physiological definitions of homeostasis are disparate and partly contradictory. Here, we address this matter by reviewing the existing knowledge considering two distinct groups, regulators and conformers and, based on examples of thermo- and osmoregulation, we propose a new approach to stoichiometric homeostasis, unifying ecological and physiological concepts. We suggest a simple and precise graphical way to identify regulators and conformers: for any given biological parameter (e.g. nutrient stoichiometry, temperature, a sigmoidal relation between internal and external conditions can be observed for conformers while an inverse sigmoidal response is characteristic of regulators. This new definition and method, based on well-studied physiological mechanisms, unifies ecological and physiological approaches and is a useful tool for understanding how organisms are affected by and affect their environment.

  20. Robust Estimation of Electron Density From Anatomic Magnetic Resonance Imaging of the Brain Using a Unifying Multi-Atlas Approach

    Energy Technology Data Exchange (ETDEWEB)

    Ren, Shangjie [Tianjin Key Laboratory of Process Measurement and Control, School of Electrical Engineering and Automation, Tianjin University, Tianjin (China); Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California (United States); Hara, Wendy; Wang, Lei; Buyyounouski, Mark K.; Le, Quynh-Thu; Xing, Lei [Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California (United States); Li, Ruijiang, E-mail: rli2@stanford.edu [Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, California (United States)

    2017-03-15

    Purpose: To develop a reliable method to estimate electron density based on anatomic magnetic resonance imaging (MRI) of the brain. Methods and Materials: We proposed a unifying multi-atlas approach for electron density estimation based on standard T1- and T2-weighted MRI. First, a composite atlas was constructed through a voxelwise matching process using multiple atlases, with the goal of mitigating effects of inherent anatomic variations between patients. Next we computed for each voxel 2 kinds of conditional probabilities: (1) electron density given its image intensity on T1- and T2-weighted MR images; and (2) electron density given its spatial location in a reference anatomy, obtained by deformable image registration. These were combined into a unifying posterior probability density function using the Bayesian formalism, which provided the optimal estimates for electron density. We evaluated the method on 10 patients using leave-one-patient-out cross-validation. Receiver operating characteristic analyses for detecting different tissue types were performed. Results: The proposed method significantly reduced the errors in electron density estimation, with a mean absolute Hounsfield unit error of 119, compared with 140 and 144 (P<.0001) using conventional T1-weighted intensity and geometry-based approaches, respectively. For detection of bony anatomy, the proposed method achieved an 89% area under the curve, 86% sensitivity, 88% specificity, and 90% accuracy, which improved upon intensity and geometry-based approaches (area under the curve: 79% and 80%, respectively). Conclusion: The proposed multi-atlas approach provides robust electron density estimation and bone detection based on anatomic MRI. If validated on a larger population, our work could enable the use of MRI as a primary modality for radiation treatment planning.

  1. Unifying the concept of consciousness across the disciplines: A concept-based, cross-cultural approach

    Science.gov (United States)

    Jones, Peter N.

    The majority of studies concerning consciousness have examined and modeled the concept of consciousness in terms of particular lines of inquiry, a process that has circumscribed the general applicability of any results from such approaches. The purpose of this dissertation was to study consciousness from a concept-based, cross-cultural approach and to attempt to unify the concept across the cultures examined. The 4 cultures are the academic disciplines of philosophy, physics, psychology, and anthropology. Consciousness was examined in terms of how the concept is framed and where the major limitations in each line of inquiry occur. The rationale for examining consciousness as a concept across 4 cultures was to determine whether there was any common component in each line's framing that could be used to unify the concept. The study found that experience itself was the primary unifying factor in each field's framing and that experience was treated as a nonreducible property within each line of inquiry. By taking experience itself (but not subjective experience) as a fundamental property, each culture's concept of consciousness becomes tractable. As such, this dissertation argues that experience should be taken as a fundamental property of the concept. The significance of this analysis is that by taking experience as a fundamental property, it becomes possible to unify the concept across the 4 cultures. This unification is presented as a unity thesis, which is a theory arguing for unification of the concept based on the fundamental of experience. Following this theoretical examination, this paper discusses several key implications of the unity thesis, including implications of the unity thesis for the current status of altered states of consciousness and for the so-called hard and easy problems associated with the concept (at least within Occidental ontology). It is argued that the so-called hard problem does not exist when experience is taken as a fundamental property

  2. New Application’s Approach to Unified Power Quality Conditioners for Mitigation of Surge Voltages

    Directory of Open Access Journals (Sweden)

    Yeison Alberto Garcés Gomez

    2016-01-01

    Full Text Available This paper outlines a new approach for the compensation of power systems presented through the use of a unified power quality conditioner (UPQC which compensates impulsive and oscillatory electromagnetic transients. The newly proposed control technique involves a dual analysis of the UPQC where the parallel compensator is modelled as a sinusoidal controlled voltage source, while the series compensator is modelled as a sinusoidal controlled current source, opposed to the traditional approach where the parallel and series compensators are modelled as current and voltage nonsinusoidal sources, respectively. Also a new compensation algorithm is proposed through the application of the theory of generalized reactive power; this is then compared with the theory of active and reactive instantaneous power, or pq theory. The results are presented by means of simulations in MATLAB-Simulink®.

  3. The Dynamics of Heat A Unified Approach to Thermodynamics and Heat Transfer

    CERN Document Server

    Fuchs, Hans U

    2010-01-01

    Based on courses for students of science, engineering, and systems science at the Zurich University of Applied Sciences at Winterthur, this text approaches the fundamentals of thermodynamics from the point of view of continuum physics. By describing physical processes in terms of the flow and balance of physical quantities, the author achieves a unified approach to hydraulics, electricity, mechanics and thermodynamics. In this way, it becomes clear that entropy is the fundamental property that is transported in thermal processes (i.e., heat), and that temperature is the corresponding potential. The resulting theory of the creation, flow, and balance of entropy provides the foundation of a dynamical theory of heat. This extensively revised and updated second edition includes new material on dynamical chemical processes, thermoelectricity, and explicit dynamical modeling of thermal and chemical processes. To make the book more useful for courses on thermodynamics and physical chemistry at different levels, cove...

  4. Unified treatment: analyticity, Regge trajectories, Veneziano amplitude, fundamental regions and Moebius transformations

    International Nuclear Information System (INIS)

    Choudhary, A.R.

    2003-01-01

    In this paper we present a unified treatment that combines the analyticity properties of the scattering amplitudes, the threshold and asymptotic behaviors, the invariance group of Moebius transformations, the automorphic functions defined over this invariance group, the fundamental region in (Poincare) geometry, and the generators of the invariance group as they relate to the fundamental region. Using these concepts and techniques, we provide a theoretical basis for Veneziano type amplitudes with the ghost elimination condition built in, related the Regge trajectory functions to the generators of the invariance group, constrained the values of the Regge trajectories to take only inverse integer values at the threshold, used the threshold behavior in the forward direction to deduce the Pomeranchuk trajectory as well as other relations. The enabling tool for this unified treatment came from the multi-sheet conformal mapping techniques that map the physical sheet to a fundamental region which in turn defines a Riemann surface on which a global uniformization variable for the scattering amplitude is calculated via an automorphic function, which in turn can be constructed as a quotient of two automorphic forms of the same dimension. (orig.)

  5. Unified semimicroscopic approach scattering of low energy protons and alpha-particles by nuclei

    International Nuclear Information System (INIS)

    Dao Tien Khoa; Kukhtina, I.N.; Knyaz'kov, O.M.; Feofilov, G.A.

    1988-01-01

    The unified approach has been developed to the description of the interaction of low energy nucleons and α-particles with nuclei. The analysis of elastic and inelastic scattering of 25.05 MeV protons and 104 MeV α-particles from 90 Zr is made. The differences in deformations of neutron and proton density distributions for 90 Zr nucleus are extracted. The energy dependence of the obtained α-particle - nucleus semimicroscopic potential is investigated, including the energy dependence for the geometry of the potential. The feaures of angular distributions of elastic α-particle scattering and the role of nucleon-nucleon correlations are analysed as a function of α-particle energy

  6. A Unified Simulation Approach for the Fast Outage Capacity Evaluation over Generalized Fading Channels

    KAUST Repository

    Rached, Nadhir B.

    2016-01-06

    The outage capacity (OC) is among the most important performance metrics of communication systems over fading channels. The evaluation of the OC, when equal gain combining (EGC) or maximum ratio combining (MRC) diversity techniques are employed, boils down to computing the cumulative distribution function (CDF) of the sum of channel envelopes (equivalently amplitudes) for EGC or channel gains (equivalently squared enveloped/ amplitudes) for MRC. Closed-form expressions of the CDF of the sum of many generalized fading variates are generally unknown and constitute open problems. We develop a unified hazard rate twisting Importance Sampling (IS) based approach to efficiently estimate the CDF of the sum of independent arbitrary variates. The proposed IS estimator is shown to achieve an asymptotic optimality criterion, which clearly guarantees its efficiency. Some selected simulation results are also shown to illustrate the substantial computational gain achieved by the proposed IS scheme over crude Monte Carlo simulations.

  7. A unified simulation approach for the fast outage capacity evaluation over generalized fading channels

    KAUST Repository

    Rached, Nadhir B.

    2015-06-14

    The outage capacity (OC) is among the most important performance metrics of communication systems over fading channels. The evaluation of the OC, when Equal Gain Combining (EGC) or Maximum Ratio Combining (MRC) diversity techniques are employed, boils down to computing the Cumulative Distribution Function (CDF) of the sum of channel envelopes (equivalently amplitudes) for EGC or channel gain (equivalently squared enveloped/amplitudes) for MRC. Closed-form expressions of the CDF of the sum of many generalized fading variates are generally unknown and constitute open problems. In this paper, we develop a unified hazard rate twisting Importance Sampling (IS) based approach to efficiently estimate the CDF of the sum of independent arbitrary variates. The proposed IS estimator is shown to achieve an asymptotic optimality criterion, which clearly guarantees its efficiency. Some selected simulation results are also shown to illustrate the substantial computational gain achieved by the proposed IS scheme over crude Monte-Carlo simulations.

  8. A unified approach for radiative losses and backscattering in optical waveguides

    International Nuclear Information System (INIS)

    Melati, D; Morichetti, F; Melloni, A

    2014-01-01

    Sidewall roughness in optical waveguides represents a severe impairment for the proper functionality of photonic integrated circuits. The interaction between the propagating mode and the roughness is responsible for both radiative losses and distributed backscattering. In this paper, a unified vision on these extrinsic loss phenomena is discussed, highlighting the fundamental role played by the sensitivity of the effective index n eff of the optical mode to waveguide width variations. The n w model presented applies to both 2D slab waveguides and 3D laterally confined waveguides and is in very good agreement with existing models that individually describe radiative loss or backscattering only. Experimental results are presented, demonstrating the validity of the n w model for arbitrary waveguide geometries and technologies. This approach enables an accurate description of realistic optical waveguides and provides simple design rules for optimization of the waveguide geometry in order to reduce the propagation losses generated by sidewall roughness. (paper)

  9. A detailed and unified treatment of spin-orbit systems using tools distilled from the theory of bundles

    International Nuclear Information System (INIS)

    Heinemann, K.; Ellison, J.A.

    2015-01-01

    We return to our study (2001) of invariant spin fields and spin tunes for polarized beams in storage rings but in contrast to the continuous-time treatment in this study, we now employ a discrete-time formalism, beginning with the Poincare maps of the continuous time formalism. We then substantially extend our toolset and generalize the notions of invariant spin field and invariant frame field. We revisit some old theorems and prove several theorems believed to be new. In particular we study two transformation rules, one of them known and the other new, where the former turns out to be an SO(3)-gauge transformation rule. We then apply the theory to the dynamics of spin-1/2 and spin-1 particle bunches and their density matrix functions, describing semiclassically the particle-spin content of bunches. Our approach thus unifies the spin-vector dynamics from the T-BMT equation with the spin-tensor dynamics and other dynamics. This unifying aspect of our approach relates the examples elegantly and uncovers relations between the various underlying dynamical systems in a transparent way. The particle motion is integrable but we now allow for nonlinear particle motion on each torus. Since this work is inspired by notions from the theory of bundles, we also provide insight into the underlying bundle-theoretic aspects of the well-established concepts of invariant spin field, spin tune and invariant frame field. Thus the group theoretical notion is exhibited. Since we neglect, as is usual, the Stern-Gerlach force, the underlying principal bundle is of product form so that we can present the theory in a fashion which does not use bundle theory. Nevertheless we occasionally mention the bundle-theoretic meaning of our concepts and we also mention the similarities with the geometrical approach to Yang-Mills Theory.

  10. A detailed and unified treatment of spin-orbit systems using tools distilled from the theory of bundles

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, K.; Ellison, J.A. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Mathematics and Statistics; Barber, D.P.; Vogt, M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2015-01-15

    We return to our study (2001) of invariant spin fields and spin tunes for polarized beams in storage rings but in contrast to the continuous-time treatment in this study, we now employ a discrete-time formalism, beginning with the Poincare maps of the continuous time formalism. We then substantially extend our toolset and generalize the notions of invariant spin field and invariant frame field. We revisit some old theorems and prove several theorems believed to be new. In particular we study two transformation rules, one of them known and the other new, where the former turns out to be an SO(3)-gauge transformation rule. We then apply the theory to the dynamics of spin-1/2 and spin-1 particle bunches and their density matrix functions, describing semiclassically the particle-spin content of bunches. Our approach thus unifies the spin-vector dynamics from the T-BMT equation with the spin-tensor dynamics and other dynamics. This unifying aspect of our approach relates the examples elegantly and uncovers relations between the various underlying dynamical systems in a transparent way. The particle motion is integrable but we now allow for nonlinear particle motion on each torus. Since this work is inspired by notions from the theory of bundles, we also provide insight into the underlying bundle-theoretic aspects of the well-established concepts of invariant spin field, spin tune and invariant frame field. Thus the group theoretical notion is exhibited. Since we neglect, as is usual, the Stern-Gerlach force, the underlying principal bundle is of product form so that we can present the theory in a fashion which does not use bundle theory. Nevertheless we occasionally mention the bundle-theoretic meaning of our concepts and we also mention the similarities with the geometrical approach to Yang-Mills Theory.

  11. Robust Pedestrian Tracking and Recognition from FLIR Video: A Unified Approach via Sparse Coding

    Directory of Open Access Journals (Sweden)

    Xin Li

    2014-06-01

    Full Text Available Sparse coding is an emerging method that has been successfully applied to both robust object tracking and recognition in the vision literature. In this paper, we propose to explore a sparse coding-based approach toward joint object tracking-and-recognition and explore its potential in the analysis of forward-looking infrared (FLIR video to support nighttime machine vision systems. A key technical contribution of this work is to unify existing sparse coding-based approaches toward tracking and recognition under the same framework, so that they can benefit from each other in a closed-loop. On the one hand, tracking the same object through temporal frames allows us to achieve improved recognition performance through dynamical updating of template/dictionary and combining multiple recognition results; on the other hand, the recognition of individual objects facilitates the tracking of multiple objects (i.e., walking pedestrians, especially in the presence of occlusion within a crowded environment. We report experimental results on both the CASIAPedestrian Database and our own collected FLIR video database to demonstrate the effectiveness of the proposed joint tracking-and-recognition approach.

  12. The Ritz - Sublaminate Generalized Unified Formulation approach for piezoelectric composite plates

    Science.gov (United States)

    D'Ottavio, Michele; Dozio, Lorenzo; Vescovini, Riccardo; Polit, Olivier

    2018-01-01

    This paper extends to composite plates including piezoelectric plies the variable kinematics plate modeling approach called Sublaminate Generalized Unified Formulation (SGUF). Two-dimensional plate equations are obtained upon defining a priori the through-thickness distribution of the displacement field and electric potential. According to SGUF, independent approximations can be adopted for the four components of these generalized displacements: an Equivalent Single Layer (ESL) or Layer-Wise (LW) description over an arbitrary group of plies constituting the composite plate (the sublaminate) and the polynomial order employed in each sublaminate. The solution of the two-dimensional equations is sought in weak form by means of a Ritz method. In this work, boundary functions are used in conjunction with the domain approximation expressed by an orthogonal basis spanned by Legendre polynomials. The proposed computational tool is capable to represent electroded surfaces with equipotentiality conditions. Free-vibration problems as well as static problems involving actuator and sensor configurations are addressed. Two case studies are presented, which demonstrate the high accuracy of the proposed Ritz-SGUF approach. A model assessment is proposed for showcasing to which extent the SGUF approach allows a reduction of the number of unknowns with a controlled impact on the accuracy of the result.

  13. GREIT: a unified approach to 2D linear EIT reconstruction of lung images.

    Science.gov (United States)

    Adler, Andy; Arnold, John H; Bayford, Richard; Borsic, Andrea; Brown, Brian; Dixon, Paul; Faes, Theo J C; Frerichs, Inéz; Gagnon, Hervé; Gärber, Yvo; Grychtol, Bartłomiej; Hahn, Günter; Lionheart, William R B; Malik, Anjum; Patterson, Robert P; Stocks, Janet; Tizzard, Andrew; Weiler, Norbert; Wolf, Gerhard K

    2009-06-01

    Electrical impedance tomography (EIT) is an attractive method for clinically monitoring patients during mechanical ventilation, because it can provide a non-invasive continuous image of pulmonary impedance which indicates the distribution of ventilation. However, most clinical and physiological research in lung EIT is done using older and proprietary algorithms; this is an obstacle to interpretation of EIT images because the reconstructed images are not well characterized. To address this issue, we develop a consensus linear reconstruction algorithm for lung EIT, called GREIT (Graz consensus Reconstruction algorithm for EIT). This paper describes the unified approach to linear image reconstruction developed for GREIT. The framework for the linear reconstruction algorithm consists of (1) detailed finite element models of a representative adult and neonatal thorax, (2) consensus on the performance figures of merit for EIT image reconstruction and (3) a systematic approach to optimize a linear reconstruction matrix to desired performance measures. Consensus figures of merit, in order of importance, are (a) uniform amplitude response, (b) small and uniform position error, (c) small ringing artefacts, (d) uniform resolution, (e) limited shape deformation and (f) high resolution. Such figures of merit must be attained while maintaining small noise amplification and small sensitivity to electrode and boundary movement. This approach represents the consensus of a large and representative group of experts in EIT algorithm design and clinical applications for pulmonary monitoring. All software and data to implement and test the algorithm have been made available under an open source license which allows free research and commercial use.

  14. GREIT: a unified approach to 2D linear EIT reconstruction of lung images

    International Nuclear Information System (INIS)

    Adler, Andy; Arnold, John H; Bayford, Richard; Tizzard, Andrew; Borsic, Andrea; Brown, Brian; Dixon, Paul; Faes, Theo J C; Frerichs, Inéz; Weiler, Norbert; Gagnon, Hervé; Gärber, Yvo; Grychtol, Bartłomiej; Hahn, Günter; Lionheart, William R B; Malik, Anjum; Patterson, Robert P; Stocks, Janet; Wolf, Gerhard K

    2009-01-01

    Electrical impedance tomography (EIT) is an attractive method for clinically monitoring patients during mechanical ventilation, because it can provide a non-invasive continuous image of pulmonary impedance which indicates the distribution of ventilation. However, most clinical and physiological research in lung EIT is done using older and proprietary algorithms; this is an obstacle to interpretation of EIT images because the reconstructed images are not well characterized. To address this issue, we develop a consensus linear reconstruction algorithm for lung EIT, called GREIT (Graz consensus Reconstruction algorithm for EIT). This paper describes the unified approach to linear image reconstruction developed for GREIT. The framework for the linear reconstruction algorithm consists of (1) detailed finite element models of a representative adult and neonatal thorax, (2) consensus on the performance figures of merit for EIT image reconstruction and (3) a systematic approach to optimize a linear reconstruction matrix to desired performance measures. Consensus figures of merit, in order of importance, are (a) uniform amplitude response, (b) small and uniform position error, (c) small ringing artefacts, (d) uniform resolution, (e) limited shape deformation and (f) high resolution. Such figures of merit must be attained while maintaining small noise amplification and small sensitivity to electrode and boundary movement. This approach represents the consensus of a large and representative group of experts in EIT algorithm design and clinical applications for pulmonary monitoring. All software and data to implement and test the algorithm have been made available under an open source license which allows free research and commercial use

  15. Unified approach to catechin hetero-oligomers: first total synthesis of trimer EZ-EG-CA isolated from Ziziphus jujuba.

    Science.gov (United States)

    Yano, Takahisa; Ohmori, Ken; Takahashi, Haruko; Kusumi, Takenori; Suzuki, Keisuke

    2012-10-14

    A catechin hetero-trimer isolated from Ziziphus jujuba has been synthesized. Among three constituent monomers, (-)-epiafzelechin and (-)-epigallocatechin were prepared by de novo synthesis. Trimer formation relied on the unified approach to oligomers based on the bromo-capping and the orthogonal activation, reaching the reported structure of the natural product.

  16. Climate Justice: A Constitutional Approach to Unify the Lex Specialis Principles of International Climate Law

    NARCIS (Netherlands)

    Thorp, Teresa

    2012-01-01

    Legal principles legitimise ubiquitous social values. They make certain social norms lawful and legitimate. Legal principles may act as governing vectors. They may give effect to a unified and legitimate constitutional framework insofar as a constitution unifies the fundamental principles on which a

  17. A Unifying Approach to Axiomatic Non-Expected Utility Theories: Correction and Comment

    NARCIS (Netherlands)

    S.H. Chew; L.G. Epstein (Larry); P.P. Wakker (Peter)

    1993-01-01

    textabstractChew and Epstein attempted to provide a unifying axiomatic framework for a number of generalizations of expected utility theory. Wakker pointed out that Theorem A, on which the central unifying proposition is based, is false. In this note, we apply Segal′s result to prove that Theorem 2

  18. A unifying approach to axiomatic non-expected utility theories: correction and comment

    NARCIS (Netherlands)

    Hong, C.S.; Epstein, L.G.; Wakker, P.

    1993-01-01

    Chew and Epstein attempted to provide a unifying axiomatic framework for a number of generalizations of expected utility theory. Wakker pointed out that Theorem A, on which the central unifying proposition is based, is false. In this note, we apply Segal's result to prove that Theorem 2 is

  19. A unified approach to the analysis and design of elasto-plastic structures with mechanical contact

    Science.gov (United States)

    Bendsoe, Martin P.; Olhoff, Niels; Taylor, John E.

    1990-01-01

    With structural design in mind, a new unified variational model has been developed which represents the mechanics of deformation elasto-plasticity with unilateral contact conditions. For a design problem formulated as maximization of the load carrying capacity of a structure under certain constraints, the unified model allows for a simultaneous analysis and design synthesis for a whole range of mechanical behavior.

  20. Unified treatment of coupled optical and acoustic phonons in piezoelectric cubic materials

    DEFF Research Database (Denmark)

    Willatzen, Morten; Wang, Zhong Lin

    2015-01-01

    A unified treatment of coupled optical and acoustic phonons in piezoelectric cubic materials is presented whereby the lattice displacement vector and the internal ionic displacement vector are found simultaneously. It is shown that phonon couplings exist in pairs only; either between the electric...... piezoelectricity in a cubic structured material slab. First, it is shown that isolated optical phonon modes generally cannot exist in piezoelectric cubic slabs. Second, we prove that confined acousto-optical phonon modes only exist for a discrete set of in-plane wave numbers in piezoelectric cubic slabs. Third...... potential and the lattice displacement coordinate perpendicular to the phonon wave vector or between the two other lattice displacement components. The former leads to coupled acousto-optical phonons by virtue of the piezoelectric effect. We then establish three new conjectures that entirely stem from...

  1. A Unified Approach to Functional Principal Component Analysis and Functional Multiple-Set Canonical Correlation.

    Science.gov (United States)

    Choi, Ji Yeh; Hwang, Heungsun; Yamamoto, Michio; Jung, Kwanghee; Woodward, Todd S

    2017-06-01

    Functional principal component analysis (FPCA) and functional multiple-set canonical correlation analysis (FMCCA) are data reduction techniques for functional data that are collected in the form of smooth curves or functions over a continuum such as time or space. In FPCA, low-dimensional components are extracted from a single functional dataset such that they explain the most variance of the dataset, whereas in FMCCA, low-dimensional components are obtained from each of multiple functional datasets in such a way that the associations among the components are maximized across the different sets. In this paper, we propose a unified approach to FPCA and FMCCA. The proposed approach subsumes both techniques as special cases. Furthermore, it permits a compromise between the techniques, such that components are obtained from each set of functional data to maximize their associations across different datasets, while accounting for the variance of the data well. We propose a single optimization criterion for the proposed approach, and develop an alternating regularized least squares algorithm to minimize the criterion in combination with basis function approximations to functions. We conduct a simulation study to investigate the performance of the proposed approach based on synthetic data. We also apply the approach for the analysis of multiple-subject functional magnetic resonance imaging data to obtain low-dimensional components of blood-oxygen level-dependent signal changes of the brain over time, which are highly correlated across the subjects as well as representative of the data. The extracted components are used to identify networks of neural activity that are commonly activated across the subjects while carrying out a working memory task.

  2. A Unified Current Loop Tuning Approach for Grid-Connected Photovoltaic Inverters

    Directory of Open Access Journals (Sweden)

    Weiyi Zhang

    2016-09-01

    Full Text Available High level penetration of renewable energy sources has reshaped modern electrical grids. For the future grid, distributed renewable power generation plants can be integrated in a larger scale. Control of grid-connected converters is required to achieve fast power reference tracking and further to present grid-supporting and fault ride-through performance. Among all of the aspects for converter control, the inner current loop for grid-connected converters characterizes the system performance considerably. This paper proposes a unified current loop tuning approach for grid-connected converters that is generally applicable in different cases. A direct discrete-time domain tuning procedure is used, and particularly, the selection of the phase margin and crossover frequency is analyzed, which acts as the main difference compared with the existing studies. As a general method, the approximation in the modeling of the controller and grid filter is avoided. The effectiveness of the tuning approach is validated in both simulation and experimental results with respect to power reference tracking, frequency and voltage supporting.

  3. Unified path integral approach to theories of diffusion-influenced reactions

    Science.gov (United States)

    Prüstel, Thorsten; Meier-Schellersheim, Martin

    2017-08-01

    Building on mathematical similarities between quantum mechanics and theories of diffusion-influenced reactions, we develop a general approach for computational modeling of diffusion-influenced reactions that is capable of capturing not only the classical Smoluchowski picture but also alternative theories, as is here exemplified by a volume reactivity model. In particular, we prove the path decomposition expansion of various Green's functions describing the irreversible and reversible reaction of an isolated pair of molecules. To this end, we exploit a connection between boundary value and interaction potential problems with δ - and δ'-function perturbation. We employ a known path-integral-based summation of a perturbation series to derive a number of exact identities relating propagators and survival probabilities satisfying different boundary conditions in a unified and systematic manner. Furthermore, we show how the path decomposition expansion represents the propagator as a product of three factors in the Laplace domain that correspond to quantities figuring prominently in stochastic spatially resolved simulation algorithms. This analysis will thus be useful for the interpretation of current and the design of future algorithms. Finally, we discuss the relation between the general approach and the theory of Brownian functionals and calculate the mean residence time for the case of irreversible and reversible reactions.

  4. A unified approach to validation, reliability, and education study design for surgical technical skills training.

    Science.gov (United States)

    Sweet, Robert M; Hananel, David; Lawrenz, Frances

    2010-02-01

    To present modern educational psychology theory and apply these concepts to validity and reliability of surgical skills training and assessment. In a series of cross-disciplinary meetings, we applied a unified approach of behavioral science principles and theory to medical technical skills education given the recent advances in the theories in the field of behavioral psychology and statistics. While validation of the individual simulation tools is important, it is only one piece of a multimodal curriculum that in and of itself deserves examination and study. We propose concurrent validation throughout the design of simulation-based curriculum rather than once it is complete. We embrace the concept that validity and curriculum development are interdependent, ongoing processes that are never truly complete. Individual predictive, construct, content, and face validity aspects should not be considered separately but as interdependent and complementary toward an end application. Such an approach could help guide our acceptance and appropriate application of these exciting new training and assessment tools for technical skills training in medicine.

  5. EKSPLORASI DAN IMPLEMENTASI UNIFIED APPROACH DALAM PERANCANGAN SISTEM INFORMASI : STUDI KASUS SISTEM RESERVASI HOTEL

    Directory of Open Access Journals (Sweden)

    Fajar Baskoro

    2002-07-01

    Full Text Available Perancangan perangkat lunak merupakan tahapan yang penting di dalam rekayasa perangkat lunak. Pemilihan perangkat perancangan yang dapat membantu memodelkan perangkat lunak menentukan kemudahan spesifikasi, implementasi, visualisasi, pengujian, dan dokumentasi perangkat lunak. UML, Unified Modelling Language sebagai Bahasa Pemodelan Terpadu mempunyai perangkat untuk memodelkan perangkat lunak memvisualisasikan use case, statis, dan perilaku perangkat lunak di dalam sistem. Penggunaan UML di dalam perancangan sistem informasi berbeda dengan penggunaan UML di dalam perangkat Lunak Waktu Nyata (Realtime. Pendekatan Unified adalah salah satu panduan yang digunakan untuk perancangan perangkat lunak dengan menggunakan UML. Kata kunci: UML, pendekatan unified, reservasi hotel.

  6. Adapting Rational Unified Process (RUP) approach in designing a secure e-Tendering model

    Science.gov (United States)

    Mohd, Haslina; Robie, Muhammad Afdhal Muhammad; Baharom, Fauziah; Darus, Norida Muhd; Saip, Mohamed Ali; Yasin, Azman

    2016-08-01

    e-Tendering is an electronic processing of the tender document via internet and allow tenderer to publish, communicate, access, receive and submit all tender related information and documentation via internet. This study aims to design the e-Tendering system using Rational Unified Process approach. RUP provides a disciplined approach on how to assign tasks and responsibilities within the software development process. RUP has four phases that can assist researchers to adjust the requirements of various projects with different scope, problem and the size of projects. RUP is characterized as a use case driven, architecture centered, iterative and incremental process model. However the scope of this study only focusing on Inception and Elaboration phases as step to develop the model and perform only three of nine workflows (business modeling, requirements, analysis and design). RUP has a strong focus on documents and the activities in the inception and elaboration phases mainly concern the creation of diagrams and writing of textual descriptions. The UML notation and the software program, Star UML are used to support the design of e-Tendering. The e-Tendering design based on the RUP approach can contribute to e-Tendering developers and researchers in e-Tendering domain. In addition, this study also shows that the RUP is one of the best system development methodology that can be used as one of the research methodology in Software Engineering domain related to secured design of any observed application. This methodology has been tested in various studies in certain domains, such as in Simulation-based Decision Support, Security Requirement Engineering, Business Modeling and Secure System Requirement, and so forth. As a conclusion, these studies showed that the RUP one of a good research methodology that can be adapted in any Software Engineering (SE) research domain that required a few artifacts to be generated such as use case modeling, misuse case modeling, activity

  7. Towards a Unified Approach to Information Integration - A review paper on data/information fusion

    Energy Technology Data Exchange (ETDEWEB)

    Whitney, Paul D.; Posse, Christian; Lei, Xingye C.

    2005-10-14

    Information or data fusion of data from different sources are ubiquitous in many applications, from epidemiology, medical, biological, political, and intelligence to military applications. Data fusion involves integration of spectral, imaging, text, and many other sensor data. For example, in epidemiology, information is often obtained based on many studies conducted by different researchers at different regions with different protocols. In the medical field, the diagnosis of a disease is often based on imaging (MRI, X-Ray, CT), clinical examination, and lab results. In the biological field, information is obtained based on studies conducted on many different species. In military field, information is obtained based on data from radar sensors, text messages, chemical biological sensor, acoustic sensor, optical warning and many other sources. Many methodologies are used in the data integration process, from classical, Bayesian, to evidence based expert systems. The implementation of the data integration ranges from pure software design to a mixture of software and hardware. In this review we summarize the methodologies and implementations of data fusion process, and illustrate in more detail the methodologies involved in three examples. We propose a unified multi-stage and multi-path mapping approach to the data fusion process, and point out future prospects and challenges.

  8. A unified momentum equation approach for computing thermal residual stresses during melting and solidification

    Science.gov (United States)

    Yeo, Haram; Ki, Hyungson

    2018-03-01

    In this article, we present a novel numerical method for computing thermal residual stresses from a viewpoint of fluid-structure interaction (FSI). In a thermal processing of a material, residual stresses are developed as the material undergoes melting and solidification, and liquid, solid, and a mixture of liquid and solid (or mushy state) coexist and interact with each other during the process. In order to accurately account for the stress development during phase changes, we derived a unified momentum equation from the momentum equations of incompressible fluids and elastoplastic solids. In this approach, the whole fluid-structure system is treated as a single continuum, and the interaction between fluid and solid phases across the mushy zone is naturally taken into account in a monolithic way. For thermal analysis, an enthalpy-based method was employed. As a numerical example, a two-dimensional laser heating problem was considered, where a carbon steel sheet was heated by a Gaussian laser beam. Momentum and energy equations were discretized on a uniform Cartesian grid in a finite volume framework, and temperature-dependent material properties were used. The austenite-martensite phase transformation of carbon steel was also considered. In this study, the effects of solid strains, fluid flow, mushy zone size, and laser heating time on residual stress formation were investigated.

  9. Possible Cosmological consequences of thermodynamics in a unified approach to gravitational and strong interactions

    International Nuclear Information System (INIS)

    Recami, E.; Tonin Zanchin, V.; Martinez, J.M.

    1986-01-01

    A unified geometrical approach to strong and gravitational interactions has been recently proposed, based on the classical methods of General Relativity. According to it, hadrons can be regarded as black-hole type solutions of new field equations describing two tensorial metric-field (the ordinary gravitational field, and the strong one). In this paper, we first seize the opportunity for an improved exposition of some elements of the theory relevant to our present scope. Secondly, by extending the Bekenstein-Hawking thermodynamics to the above mentioned strong black-holes (SBH), it is shown: 1) that SBH thermodynamics seems to require a new expansion of our cosmos after its Big Crunch (i.e. that a recontraction of our cosmos has to be followed by a new creation); 2) that a collapsing star with mass M approximately in the range 3 to 5 solar masses, once reached the neutron-star density, could re-explode tending to form a (radiating) object with a diameter of the order of 1 light-day: thus failing to create a gravitational black-hole

  10. A unified approach to assess performance of different techniques for recovering exhaust heat from gas turbines

    International Nuclear Information System (INIS)

    Carapellucci, Roberto

    2009-01-01

    Exhaust heat from gas turbines can be recovered externally or internally to the cycle itself. Of the technology options for external recovery, the combined gas-steam power plant is by far the most effective and commonly used worldwide. For internal recovery conventional solutions are based on thermodynamic regeneration and steam injection, while innovative solutions rely on humid air regeneration and steam reforming of fuel. In this paper a unified approach for analysing different exhaust heat recovery techniques is proposed. It has been possible to define a characteristic internal heat recovery plane, based on a few meaningful parameters and to identify an innovative scheme for repowering existing combined cycles. The characteristic plane indicates directly the performance obtainable with the different recovery techniques, showing that performances close to combined cycle plants (external recovery) can only be achieved with combined recovery techniques (humid air regeneration, steam reforming of fuel). The innovative repowering scheme, which requires the addition of a gas turbine and one-pressure level HRSG to an existing combined gas-steam power plant, significantly increases power output with fairly high marginal efficiency.

  11. A unified effective-field renormalization-group framework approach for the quenched diluted Ising models

    Science.gov (United States)

    de Albuquerque, Douglas F.; Fittipaldi, I. P.

    1994-05-01

    A unified effective-field renormalization-group framework (EFRG) for both quenched bond- and site-diluted Ising models is herein developed by extending recent works. The method, as in the previous works, follows up the same strategy of the mean-field renormalization-group scheme (MFRG), and is achieved by introducing an alternative way for constructing classical effective-field equations of state, based on rigorous Ising spin identities. The concentration dependence of the critical temperature, Tc(p), and the critical concentrations of magnetic atoms, pc, at which the transition temperature goes to zero, are evaluated for several two- and three-dimensional lattice structures. The obtained values of Tc and pc and the resulting phase diagrams for both bond and site cases are much more accurate than those estimated by the standard MFRG approach. Although preserving the same level of simplicity as the MFRG, it is shown that the present EFRG method, even by considering its simplest size-cluster version, provides results that correctly distinguishes those lattices that have the same coordination number, but differ in dimensionality or geometry.

  12. Development of a unified transport approach for the assessment of power-plant impact

    International Nuclear Information System (INIS)

    Akin, E.J.; Barton, J.M.; Bledsoe, J.L.

    1977-01-01

    Progress during the first 18 months in implementation of the Unified Transport Approach (UTA) is summarized in this report, which covers the period through December 1976. The goal of this project is to develop mathematical models for fast-transient, one-and two-dimensional transport of thermal, radiological, chemical, and biological properties in rivers, estuaries, lakes, and coastal regions for assessing the impact of power-plant operations. Development and validation of these models are illustrated in applications at several sites where data is available. The models include submodels for sediment transport, exchange of a soluble isotope with sediment, and zone-matching models to connect near-field problems of reentrainment and recirculation with far-field convective transport. Several types of automated data preparation have been introduced, and the codes have been designed to allow input of specified plant operating conditions for given durations. The UTA provides a common basis for calculating the transport of intensive quantities that depend on basic flow properties, which can be obtained from a common set of data for geometry, bathymetry, and meteorology that must be prepared only once. The formulation and calculation are based on a stable set of algorithms that have been tested and proven valid. The user can then focus on understanding and interpreting thermal, chemical, or radiological transport results with confidence that the basic calculations are direct, efficient, and meaningful. Recent work in each of the three areas is described

  13. A unified conformational selection and induced fit approach to protein-peptide docking.

    Directory of Open Access Journals (Sweden)

    Mikael Trellet

    Full Text Available Protein-peptide interactions are vital for the cell. They mediate, inhibit or serve as structural components in nearly 40% of all macromolecular interactions, and are often associated with diseases, making them interesting leads for protein drug design. In recent years, large-scale technologies have enabled exhaustive studies on the peptide recognition preferences for a number of peptide-binding domain families. Yet, the paucity of data regarding their molecular binding mechanisms together with their inherent flexibility makes the structural prediction of protein-peptide interactions very challenging. This leaves flexible docking as one of the few amenable computational techniques to model these complexes. We present here an ensemble, flexible protein-peptide docking protocol that combines conformational selection and induced fit mechanisms. Starting from an ensemble of three peptide conformations (extended, a-helix, polyproline-II, flexible docking with HADDOCK generates 79.4% of high quality models for bound/unbound and 69.4% for unbound/unbound docking when tested against the largest protein-peptide complexes benchmark dataset available to date. Conformational selection at the rigid-body docking stage successfully recovers the most relevant conformation for a given protein-peptide complex and the subsequent flexible refinement further improves the interface by up to 4.5 Å interface RMSD. Cluster-based scoring of the models results in a selection of near-native solutions in the top three for ∼75% of the successfully predicted cases. This unified conformational selection and induced fit approach to protein-peptide docking should open the route to the modeling of challenging systems such as disorder-order transitions taking place upon binding, significantly expanding the applicability limit of biomolecular interaction modeling by docking.

  14. Some aspects of a unified approach to gauge, dual and Gribov theories

    International Nuclear Information System (INIS)

    Veneziano, G.

    1976-01-01

    Quantum chromodynamics (QCD) with Nsub(c) colours and Nsub(f) flavours is considered. Large N expansions for this theory are discussed and their advantages are pointed out, especially in relation to the possibility of unifying gauge, dual and Gribov theories of strong interactions. First it is recalled how the 1/Nsub(c) expansion of 't Hooft can be related to a dual loop expansion with a fixed coupling constant. The necessity for quarkless (purely gluonic) bound states to appear and their importance in maintaining confinement at higher orders in 1/Nsub(c) is pointed out. It is shown how non-orientable dual loops are reinterpreted in QCD and how a paradox appears when Nsub(f) is such that asymptotic freedom is lost. Some recent results of Cornwall and Tiktopoulos are analyzed in leading order in 1/Nsub(c). Then a 1/N expansion is introduced at rho equivalent to Nsub(f)/Nsub(c) fixed and it is shown how it is related to the hadronic topological expansion (TE). This allows an unambiguous definition of reggeon field theory concepts such as the bare pomeron and diffractive dissociation in QCD. The parameter rho is related to the clustering of hadronic final states into resonances. Decreasing rho corresponds to increasing cluster over gap size. Renormalization of the dual coupling constant as a function of rho is discussed and an apparent paradox is resolved. Some new light on the problem of f extinction in the TE is also shed. Finally, the approach is compared to other schemes trying to relate different aspects of hadron physics. (Auth.)

  15. Robust Hydrological Forecasting for High-resolution Distributed Models Using a Unified Data Assimilation Approach

    Science.gov (United States)

    Hernandez, F.; Liang, X.

    2017-12-01

    Reliable real-time hydrological forecasting, to predict important phenomena such as floods, is invaluable to the society. However, modern high-resolution distributed models have faced challenges when dealing with uncertainties that are caused by the large number of parameters and initial state estimations involved. Therefore, to rely on these high-resolution models for critical real-time forecast applications, considerable improvements on the parameter and initial state estimation techniques must be made. In this work we present a unified data assimilation algorithm called Optimized PareTo Inverse Modeling through Inverse STochastic Search (OPTIMISTS) to deal with the challenge of having robust flood forecasting for high-resolution distributed models. This new algorithm combines the advantages of particle filters and variational methods in a unique way to overcome their individual weaknesses. The analysis of candidate particles compares model results with observations in a flexible time frame, and a multi-objective approach is proposed which attempts to simultaneously minimize differences with the observations and departures from the background states by using both Bayesian sampling and non-convex evolutionary optimization. Moreover, the resulting Pareto front is given a probabilistic interpretation through kernel density estimation to create a non-Gaussian distribution of the states. OPTIMISTS was tested on a low-resolution distributed land surface model using VIC (Variable Infiltration Capacity) and on a high-resolution distributed hydrological model using the DHSVM (Distributed Hydrology Soil Vegetation Model). In the tests streamflow observations are assimilated. OPTIMISTS was also compared with a traditional particle filter and a variational method. Results show that our method can reliably produce adequate forecasts and that it is able to outperform those resulting from assimilating the observations using a particle filter or an evolutionary 4D variational

  16. A unified approach to determining forms for the 2D Navier-Stokes equations -- the general interpolants case

    International Nuclear Information System (INIS)

    Foias, C; Jolly, M S; Kravchenko, R; Titi, E S

    2014-01-01

    It is shown that the long-time dynamics (the global attractor) of the 2D Navier-Stokes system is embedded in the long-time dynamics of an ordinary differential equation, called a determining form, in a space of trajectories which is isomorphic to C b 1 (R;R N ) for sufficiently large N depending on the physical parameters of the Navier-Stokes equations. A unified approach is presented, based on interpolant operators constructed from various determining parameters for the Navier-Stokes equations, namely, determining nodal values, Fourier modes, finite volume elements, finite elements, and so on. There are two immediate and interesting consequences of this unified approach. The first is that the constructed determining form has a Lyapunov function, and thus its solutions converge to the set of steady states of the determining form as the time goes to infinity. The second is that these steady states of the determining form can be uniquely identified with the trajectories in the global attractor of the Navier-Stokes system. It should be added that this unified approach is general enough that it applies, in an almost straightforward manner, to a whole class of dissipative dynamical systems. Bibliography: 23 titles

  17. Quality of life in stomized oncological patients: an approach of integrality from Brazilian Unified Health System

    Directory of Open Access Journals (Sweden)

    Cristilene Akiko Kimura

    2016-01-01

    Full Text Available Introduction: Integrality is considered an essential constitutional doctrinal principle of SUS, being considered as a major challenge in health in Brazil. This involves practicing focusing on the quality of life of oncological stomized people. Objective: To analyze quality of life of oncological stomized people from the Health Department, the Federal District, Brazil, from the perspective of integrality of the Unified Health System in Brazil. Methods: Cross-sectional, exploratory and descriptive study with a quantitative and qualitative approach in the light of a content analysis. This was a convenience sample, including 120 patients registered in the Stomized People Program of the Health Department, the Federal District, Brazil. In this study, sociodemographic, clinical, and WHOQOL-bref questionnaires and an individual interview were used. Data were analyzed by Microsoft® Office Excel 2010 program and SPSS 20.0 software. Statistical significance was accepted at 5%. Results: Physical, Social Affairs, and Environment domains are correlated with the mean score, with statistically significant results (p < 0.0001, the content analysis resulted in three categories: complications with the stoma, self-care, and Comprehensive health care. Conclusion: Our results highlight the need to realize the integrality as a principle at various levels of discussion and of the practice of health care for stomized oncological people. Resumo: Introdução: A integralidade é considerada um princípio doutrinário constitucional e essencial do SUS, e é apreciada como um grande desafio no âmbito da saúde no Brasil. Isto implica práticas voltadas para a qualidade de vida das pessoas oncológicas estomizadas. Objetivo: Analisar a qualidade de vida de pessoas oncológicas estomizadas da Secretária de Saúde do Distrito Federal, Brasil, sob a perspectiva da integralidade do Sistema Único de Saúde do Brasil. Métodos: Estudo transversal, explorat

  18. Feasibility of a unified approach to intensity-modulated radiation therapy and volume-modulated arc therapy optimization and delivery

    International Nuclear Information System (INIS)

    Hoover, Douglas A.; Chen, Jeff Z.; MacFarlane, Michael; Wong, Eugene; Battista, Jerry J.

    2015-01-01

    Purpose: To study the feasibility of unified intensity-modulated arc therapy (UIMAT) which combines intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) optimization and delivery to produce superior radiation treatment plans, both in terms of dose distribution and efficiency of beam delivery when compared with either VMAT or IMRT alone. Methods: An inverse planning algorithm for UIMAT was prototyped within the PINNACLE treatment planning system (Philips Healthcare). The IMRT and VMAT deliveries are unified within the same arc, with IMRT being delivered at specific gantry angles within the arc. Optimized gantry angles for the IMRT and VMAT phases are assigned automatically by the inverse optimization algorithm. Optimization of the IMRT and VMAT phases is done simultaneously using a direct aperture optimization algorithm. Five treatment plans each for prostate, head and neck, and lung were generated using a unified optimization technique and compared with clinical IMRT or VMAT plans. Delivery verification was performed with an ArcCheck phantom (Sun Nuclear) on a Varian TrueBeam linear accelerator (Varian Medical Systems). Results: In this prototype implementation, the UIMAT plans offered the same target dose coverage while reducing mean doses to organs at risk by 8.4% for head-and-neck cases, 5.7% for lung cases, and 3.5% for prostate cases, compared with the VMAT or IMRT plans. In addition, UIMAT can be delivered with similar efficiency as VMAT. Conclusions: In this proof-of-concept work, a novel radiation therapy optimization and delivery technique that interlaces VMAT or IMRT delivery within the same arc has been demonstrated. Initial results show that unified VMAT/IMRT has the potential to be superior to either standard IMRT or VMAT

  19. A unified approach to computing real and complex zeros of zero-dimensional ideals

    NARCIS (Netherlands)

    J.B. Lasserre; M. Laurent (Monique); P. Rostalski; M. Putinar; S. Sullivant

    2009-01-01

    textabstractIn this paper we propose a unified methodology for computing the set $V_K(I)$ of complex ($K = C$) or real ($K = R$) roots of an ideal $I$ in $R[x]$, assuming $V_K(I)$ is finite. We show how moment matrices, defined in terms of a given set of generators of the ideal I, can be used to

  20. Database Capture of Natural Language Echocardiographic Reports: A Unified Medical Language System Approach

    OpenAIRE

    Canfield, K.; Bray, B.; Huff, S.; Warner, H.

    1989-01-01

    We describe a prototype system for semi-automatic database capture of free-text echocardiography reports. The system is very simple and uses a Unified Medical Language System compatible architecture. We use this system and a large body of texts to create a patient database and develop a comprehensive hierarchical dictionary for echocardiography.

  1. Climate Justice: A Constitutional Approach to Unify the Lex Specialis Principles of International Climate Law

    Directory of Open Access Journals (Sweden)

    Teresa Thorp

    2012-11-01

    Full Text Available Legal principles legitimise ubiquitous social values. They make certain social norms lawful and legitimate. Legal principles may act as governing vectors. They may give effect to a unified and legitimate constitutional framework insofar as a constitution unifies the fundamental principles on which a state or competent authority is governed.Concerning international climate law, however, there is a certain shortcoming. The failure to comprehend a unified constitutional framework of lex specialis principles could debilitate intra and inter-regime governance and lead to uncertainties. At one time, uncertainties incite the law-making process. At another time, they constrain it. Such a shortcoming may lead to inconsistencies in interpreting consequential climate norms. It may thwart dispute resolution and it may impede climate negotiations. To traverse this abyss, the inquiry uses instruments of legal philosophy (the philosophy of language, legal systematics (the study of legal systems, and legal hermeneutics (the legal practice of interpretation to delineate, distinguish and unify lex specialis principles that could form the foundations of a universal constitutional framework of international climate law. In doing so, it shows that climate justice is a function of the quality of the legal system.

  2. A unified approach for description of gas hydrate formation kinetics in the presence of kinetic promoters in gas hydrate converters

    International Nuclear Information System (INIS)

    ZareNezhad, Bahman; Varaminian, Farshad

    2013-01-01

    Highlights: • A unified kinetic model for description of promoted and non-promoted gas hydrate formation processes is presented. • Effects of impeller speed, promoter concentration and different kinetic promoters are investigated. • A unique region of gas hydrate formation is identified regarding gas hydrate formation processes. • The proposed model is useful for understanding the behavior of gas hydrate formation processes and design of GTH converters. - Abstract: The kinetic promoters have found wide applications in enhancing the rate of energy conversion and storage via gas hydrate formation processes. Effects of different kinetic promoters such as anionic surfactants sodium dodecyl sulfate (SDS), dodecylbenzene sulfonic acid (DBSA), and sodium dodecyl benzene sulfonate (SDBS); cationic surfactants, Cetyl trimethyl ammonium bromide (CTAB), dodecyl trimethyl ammonium bromide (DTAB) and non-ionic surfactants, alkylpolyglucoside (APG), dodecyl polysaccharide glycoside (DPG), TritonX-100 (TX100) on methane (CH 4 ), ethane (C 2 H 6 ) and propane (C 3 H 8 ) gas hydrate formation processes are investigated in this work. A macroscopic kinetic model based on the time variations of reaction chemical potential is also presented for global description of gas hydrate formation processes. Experimental gas hydrate formation data are employed to validate the proposed kinetic model. Effects of promoter’s concentrations and agitation intensities on the gas consumption profiles are also investigated. A universal correlation and a unified kinetic map have been proposed for macroscopic description of gas hydrate formation kinetics in the presence or absence of kinetic promoters. According to the presented unified kinetic map, a unique region of gas hydrate formation is identified for the first time. For negligible amounts of kinetic promoters, the presented region disappears and approaches to a unique path at high agitation intensities. The presented unified approach is

  3. Approaches to methadone treatment

    DEFF Research Database (Denmark)

    Järvinen, Margaretha

    2008-01-01

    and does not focus on the consequences of drug use alone but also on their problematic relationship to drugs (legal as well as illegal). Furthermore, the users’ attitudes towards methadone are far more ambivalent than the staff's. For the users, methadone is not just medicine; it is also a dependence...... in the model are three dimensions (1) treatment goals at the methadone centres (abstinence vs. stabilisation) (2) treatment focus (focus on addiction vs. focus on the consequences of addiction) and (3) conceptualisation of methadone (methadone as similar to or different from heroin). The paper shows......-producing and ‘dangerous’ drug....

  4. The unified approach to integrable relativistic equations: Soliton solutions over non-vanishing backgrounds - 1

    International Nuclear Information System (INIS)

    Barashenkov, I.V.; Getmanov, B.S.; Kovtun, V.E.

    1992-01-01

    The scheme for unified description of integrable relativistic massive systems provides an inverse scattering formalism that covers universally all (1+1)- dimensional systems of this kind. In this work we construct the N-soliton solution (over an arbitrary background) for some generic system which is associated with the sl(2,C) case of the scheme and whose reductions include the complex sine-Gordon equation, the massive Thirring model and other equations, both in the Euclidean and Minkowski spaces. Thus the N-soliton solutions for all these systems emerge in a unified form differing only in the type of constraints imposed on their parameters. In an earlier paper the case of the zero background was considered while here we concentrate on the case of the non-vanishing constant background i.e., on the N-kink solutions. (author). 18 refs

  5. A Unified Approach to Diffusion Direction Sensitive Slice Registration and 3-D DTI Reconstruction From Moving Fetal Brain Anatomy

    DEFF Research Database (Denmark)

    Hansen, Mads Fogtmann; Seshamani, Sharmishtaa; Kroenke, Christopher

    2014-01-01

    to the underlying anatomy. Previous image registration techniques have been described to estimate the between slice fetal head motion, allowing the reconstruction of 3D a diffusion estimate on a regular grid using interpolation. We propose Approach to Unified Diffusion Sensitive Slice Alignment and Reconstruction...... (AUDiSSAR) that explicitly formulates a process for diffusion direction sensitive DW-slice-to-DTI-volume alignment. This also incorporates image resolution modeling to iteratively deconvolve the effects of the imaging point spread function using the multiple views provided by thick slices acquired...

  6. Neutrino-nucleus cross-sections: a unified theoretical approach for nucleon knock-out, coherent and incoherent pion production

    CERN Document Server

    Martini, M; G. Chanfray; Marteau, J

    2010-01-01

    Neutrino-nucleus cross-sections are needed to interpret neutrino oscillation data, as neutrino detectors involve complex nuclei. We present a theory of neutrino interactions with nuclei aimed at a unified description of the partial cross-sections, namely quasi-elastic and multi-nucleon emission, coherent and incoherent single pion production. We compare our approach to the available neutrino experimental data on carbon. We also discuss the evolution of the neutrino cross-sections with the mass number in view of future precision ex- periments which will use a liquid argon chamber.

  7. Unified approach for the optimization of energy and water in multipurpose batch plants using a flexible scheduling framework

    CSIR Research Space (South Africa)

    Adekola, O

    2013-05-01

    Full Text Available & Engineering Chemistry Research Vol. 52(25)/ pp 8488-8506 Unified Approach for the Optimization of Energy and Water in Multipurpose Batch Plants Using a Flexible Scheduling Framework Omobolanle Adekola,† Jane D. Stamp,† Thokozani Majozi,*,†,‡ Anurag... Garg,§ and Santanu Bandyopadhyay⊥ †Department of Chemical Engineering, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa ‡Modelling and Digital S ien e, S , Meiring aud oad, retoria, 02, South Africa §Centre...

  8. A unified approach to the minimal unitary realizations of noncompact groups and supergroups

    International Nuclear Information System (INIS)

    Guenaydin, Murat; Pavlyk, Oleksandr

    2006-01-01

    We study the minimal unitary representations of non-compact groups and supergroups obtained by quantization of their geometric realizations as quasi-conformal groups and supergroups. The quasi-conformal groups G leave generalized light-cones defined by a quartic norm invariant and have maximal rank subgroups of the form H x SL(2, R) such that G/H x SL(2, R) are para-quaternionic symmetric spaces. We give a unified formulation of the minimal unitary representations of simple non-compact groups of type A 2 , G 2 , D 4 , F 4 , E 6 , E 7 , E 8 and Sp(2n, R). The minimal unitary representations of Sp(2n, R) are simply the singleton representations and correspond to a degenerate limit of the unified construction. The minimal unitary representations of the other noncompact groups SU(m, n), SO(m, n), SO*(2n) and SL(m, R) are also given explicitly. We extend our formalism to define and construct the corresponding minimal representations of non-compact supergroups G whose even subgroups are of the form H x SL(2, R). If H is noncompact then the supergroup G does not admit any unitary representations, in general. The unified construction with H simple or Abelian leads to the minimal representations of G(3), F(4) and O Sp(n|2, R) (in the degenerate limit). The minimal unitary representations of O Sp(n|2, R) with even subgroups SO(n) x SL(2, R) are the singleton representations. We also give the minimal realization of the one parameter family of Lie superalgebras D(2, 1; σ)

  9. A global wave-driven magnetohydrodynamic solar model with a unified treatment of open and closed magnetic field topologies

    Energy Technology Data Exchange (ETDEWEB)

    Oran, R.; Van der Holst, B.; Landi, E.; Jin, M.; Sokolov, I. V.; Gombosi, T. I., E-mail: oran@umich.edu [Atmospheric, Oceanic and Atmospheric Sciences, University of Michigan, 2455 Hayward, Ann Arbor, MI, 48105 (United States)

    2013-12-01

    We describe, analyze, and validate the recently developed Alfvén Wave Solar Model, a three-dimensional global model starting from the top of the chromosphere and extending into interplanetary space (out to 1-2 AU). This model solves the extended, two-temperature magnetohydrodynamics equations coupled to a wave kinetic equation for low-frequency Alfvén waves. In this picture, heating and acceleration of the plasma are due to wave dissipation and to wave pressure gradients, respectively. The dissipation process is described by a fully developed turbulent cascade of counterpropagating waves. We adopt a unified approach for calculating the wave dissipation in both open and closed magnetic field lines, allowing for a self-consistent treatment in any magnetic topology. Wave dissipation is the only heating mechanism assumed in the model; no geometric heating functions are invoked. Electron heat conduction and radiative cooling are also included. We demonstrate that the large-scale, steady state (in the corotating frame) properties of the solar environment are reproduced, using three adjustable parameters: the Poynting flux of chromospheric Alfvén waves, the perpendicular correlation length of the turbulence, and a pseudoreflection coefficient. We compare model results for Carrington rotation 2063 (2007 November-December) with remote observations in the extreme-ultraviolet and X-ray ranges from the Solar Terrestrial Relations Observatory, Solar and Heliospheric Observatory, and Hinode spacecraft and with in situ measurements by Ulysses. The results are in good agreement with observations. This is the first global simulation that is simultaneously consistent with observations of both the thermal structure of the lower corona and the wind structure beyond Earth's orbit.

  10. A Preliminary Investigation of the Long-Term Outcome of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders

    Science.gov (United States)

    Bullis, Jacqueline R.; Fortune, Meghan R.; Farchione, Todd J.; Barlow, David H.

    2014-01-01

    Objective To conduct a preliminary examination of long-term outcomes on a broad range of affective disorder symptoms treated with a newly developed intervention: The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP). Method Maintenance of treatment gains at long-term follow-up (LTFU) were explored in patients (n = 15, mean age = 32.27; 60% female) who completed a clinical trial of the UP. Results Treatment gains observed at 6-month follow-up (6MFU) on measures of clinical severity, general symptoms of depression and anxiety, and a measure of symptom interference in daily functioning were largely maintained 12 months later (at an average of 18 months posttreatment), and any significant changes from 6MFU to LTFU reflected small increases in symptoms that remained, on average, in the subclinical range. Conclusions These findings provide the first initial support for the durability of broad treatment gains following transdiagnostic treatment. PMID:25113056

  11. Obtaining Material Data for Heat Treatment Simulation of Casr Alloy Parts with Unified Models

    DEFF Research Database (Denmark)

    Bellini, Anna; Thorborg, Jesper; Hattel, Jesper

    2004-01-01

    subjected to high temperature. In this paper a two-state variables unified model is applied in order to simulate creep behavior and time-dependent metallurgical changes. The fundamental assumption of the unified theory is that creep and viscoplasticity, which are both irreversible strains developed because...... study. The results obtained for the simulation of tensile tests and of creep tests are compared with experimental curves, showing a good agreement.......The objective of this work, which is part of the IDEAL (Integrated Development Routes for Optimized Cast Aluminium Components) project, financed by the EU in frame work 6 and born in collaboration with the automobile and foundry industries, is to simulate creep behavior of aluminum cast samples...

  12. Toward a unified approach to dose-response modeling in ecotoxicology.

    Science.gov (United States)

    Ritz, Christian

    2010-01-01

    This study reviews dose-response models that are used in ecotoxicology. The focus lies on clarification of differences and similarities between models, and as a side effect, their different guises in ecotoxicology are unravelled. A look at frequently used dose-response models reveals major discrepancies, among other things in naming conventions. Therefore, there is a need for a unified view on dose-response modeling in order to improve the understanding of it and to facilitate communication and comparison of findings across studies, thus realizing its full potential. This study attempts to establish a general framework that encompasses most dose-response models that are of interest to ecotoxicologists in practice. The framework includes commonly used models such as the log-logistic and Weibull models, but also features entire suites of models as found in various guidance documents. An outline on how the proposed framework can be implemented in statistical software systems is also provided.

  13. Graph-based stochastic control with constraints: A unified approach with perfect and imperfect measurements

    KAUST Repository

    Agha-mohammadi, Ali-akbar

    2013-06-01

    This paper is concerned with the problem of stochastic optimal control (possibly with imperfect measurements) in the presence of constraints. We propose a computationally tractable framework to address this problem. The method lends itself to sampling-based methods where we construct a graph in the state space of the problem, on which a Dynamic Programming (DP) is solved and a closed-loop feedback policy is computed. The constraints are seamlessly incorporated to the control policy selection by including their effect on the transition probabilities of the graph edges. We present a unified framework that is applicable both in the state space (with perfect measurements) and in the information space (with imperfect measurements).

  14. Decision-making in the Unified Patent Court: Ensuring a balanced approach

    DEFF Research Database (Denmark)

    Schovsbo, Jens Hemmingsen; Petersen, Clement Salung

    2016-01-01

    The Unified Patent Court (UPC) will become a central player in the future development of European patent law. For this reason it becomes important to ensure that UPC‘s decision-making reflects the double-function of the Court as an adjudicator of individual disputes and a policy maker. Because...... of its institutional design, the UPC will be biased towards technology based values. Therefore, there is a risk that non-technical values and interests will be either overlooked or underdeveloped in UPC decision-making which is likely to jeopardize public trust and legitimacy of its decisions. This paper...... analyses how these blind spots can be covered in patent litigation before the UPC within the current legislative framework. The paper focuses on the role of UPC judges as case-managers and decision-makers, on the potential role of third party interveners, and addresses the key role of the parties...

  15. Algorithms and programs of dynamic mixture estimation unified approach to different types of components

    CERN Document Server

    Nagy, Ivan

    2017-01-01

    This book provides a general theoretical background for constructing the recursive Bayesian estimation algorithms for mixture models. It collects the recursive algorithms for estimating dynamic mixtures of various distributions and brings them in the unified form, providing a scheme for constructing the estimation algorithm for a mixture of components modeled by distributions with reproducible statistics. It offers the recursive estimation of dynamic mixtures, which are free of iterative processes and close to analytical solutions as much as possible. In addition, these methods can be used online and simultaneously perform learning, which improves their efficiency during estimation. The book includes detailed program codes for solving the presented theoretical tasks. Codes are implemented in the open source platform for engineering computations. The program codes given serve to illustrate the theory and demonstrate the work of the included algorithms.

  16. [Modern treatment approaches to gambling].

    Science.gov (United States)

    Egorov, A Iu

    2014-01-01

    Compulsive gambling has received widespread attention in the last decade. Gambling has become the first non-chemical addiction, which went down to the section "Addiction and related disorders" of the modern DSM-V. The review considers non-pharmacological and pharmacological approaches to the treatment of gambling. Among non-drug approaches, cognitive-behavioral therapy and 12-step programs have gained the most popularity in the "Gamblers Anonymous" community. Among pharmacological approaches, three classes of drugs: antidepressants (mainly SSRIs), opiate antagonists (naltrexone and nalmefene) and mood stabilizers (valproate, lithium, topiramate) proved to be effective in treatment of gambling. No differences in the efficacy of the three classes of psychotropic drugs have been identified. Preliminary results for N-acetylcysteine and memantine cause optimism in terms of perspective.

  17. A unified approach to fixed-order controller design via linear matrix inequalities

    Directory of Open Access Journals (Sweden)

    Iwasaki T.

    1995-01-01

    Full Text Available We consider the design of fixed-order (or low-order linear controllers which meet certain performance and/or robustness specifications. The following three problems are considered; covariance control as a nominal performance problem, 𝒬 -stabilization as a robust stabilization problem, and robust L ∞ control problem as a robust performance problem. All three control problems are converted to a single linear algebra problem of solving a linear matrix inequality (LMI of the type B G C + ( B G C T + Q < 0 for the unknown matrix G . Thus this paper addresses the fixed-order controller design problem in a unified way. Necessary and sufficient conditions for the existence of a fixed-order controller which satisfies the design specifications for each problem are derived, and an explicit controller formula is given. In any case, the resulting problem is shown to be a search for a (structured positive definite matrix X such that X ∈ 𝒞 1 and X − 1 ∈ 𝒞 2 where 𝒞 1 and 𝒞 2 are convex sets defined by LMIs. Computational aspects of the nonconvex LMI problem are discussed.

  18. A unified approach to fixed-order controller design via linear matrix inequalities

    Directory of Open Access Journals (Sweden)

    T. Iwasaki

    1995-01-01

    Full Text Available We consider the design of fixed-order (or low-order linear controllers which meet certain performance and/or robustness specifications. The following three problems are considered; covariance control as a nominal performance problem,-stabilization as a robust stabilization problem, and robust L∞ control problem as a robust performance problem. All three control problems are converted to a single linear algebra problem of solving a linear matrix inequality (LMI of the type BGC+(BGCT+Q<0 for the unknown matrix G. Thus this paper addresses the fixed-order controller design problem in a unified way. Necessary and sufficient conditions for the existence of a fixed-order controller which satisfies the design specifications for each problem are derived, and an explicit controller formula is given. In any case, the resulting problem is shown to be a search for a (structured positive definite matrix X such that X∈1 and X−1∈2 where 1 and 2 are convex sets defined by LMIs. Computational aspects of the nonconvex LMI problem are discussed.

  19. Unified selective sorting approach to analyse multi-electrode extracellular data

    Science.gov (United States)

    Veerabhadrappa, R.; Lim, C. P.; Nguyen, T. T.; Berk, M.; Tye, S. J.; Monaghan, P.; Nahavandi, S.; Bhatti, A.

    2016-01-01

    Extracellular data analysis has become a quintessential method for understanding the neurophysiological responses to stimuli. This demands stringent techniques owing to the complicated nature of the recording environment. In this paper, we highlight the challenges in extracellular multi-electrode recording and data analysis as well as the limitations pertaining to some of the currently employed methodologies. To address some of the challenges, we present a unified algorithm in the form of selective sorting. Selective sorting is modelled around hypothesized generative model, which addresses the natural phenomena of spikes triggered by an intricate neuronal population. The algorithm incorporates Cepstrum of Bispectrum, ad hoc clustering algorithms, wavelet transforms, least square and correlation concepts which strategically tailors a sequence to characterize and form distinctive clusters. Additionally, we demonstrate the influence of noise modelled wavelets to sort overlapping spikes. The algorithm is evaluated using both raw and synthesized data sets with different levels of complexity and the performances are tabulated for comparison using widely accepted qualitative and quantitative indicators. PMID:27339770

  20. A unified approach to infrared aerosol remote sensing and type specification

    Directory of Open Access Journals (Sweden)

    L. Clarisse

    2013-02-01

    Full Text Available Atmospheric aerosols impact air quality and global climate. Space based measurements are the best way to observe their spatial and temporal distributions, and can also be used to gain better understanding of their chemical, physical and optical properties. Aerosol composition is the key parameter affecting the refractive index, which determines how much radiation is scattered and absorbed. Composition of aerosols is unfortunately not measured by state of the art satellite remote sounders. Here we use high resolution infrared measurements for aerosol type differentiation, exploiting, in that part of spectrum, the dependency of their refractive index on wavelength. We review existing detection methods and present a unified detection method based on linear discrimination analysis. We demonstrate this method on measurements of the Infrared Atmospheric Sounding Interferometer (IASI and five different aerosol types, namely volcanic ash, windblown sand, sulfuric acid droplets, ammonium sulfate and smoke particles. We compare these with traditional MODIS AOD measurements. The detection of the last three types is unprecedented in the infrared in nadir mode, but is very promising, especially for sulfuric acid droplets which are detected in the lower troposphere and up to 6 months after injection in the upper troposphere/lower stratosphere.

  1. Automatic Polyp Detection via A Novel Unified Bottom-up and Top-down Saliency Approach.

    Science.gov (United States)

    Yuan, Yixuan; Li, Dengwang; Meng, Max Q-H

    2017-07-31

    In this paper, we propose a novel automatic computer-aided method to detect polyps for colonoscopy videos. To find the perceptually and semantically meaningful salient polyp regions, we first segment images into multilevel superpixels. Each level corresponds to different sizes of superpixels. Rather than adopting hand-designed features to describe these superpixels in images, we employ sparse autoencoder (SAE) to learn discriminative features in an unsupervised way. Then a novel unified bottom-up and top-down saliency method is proposed to detect polyps. In the first stage, we propose a weak bottom-up (WBU) saliency map by fusing the contrast based saliency and object-center based saliency together. The contrast based saliency map highlights image parts that show different appearances compared with surrounding areas while the object-center based saliency map emphasizes the center of the salient object. In the second stage, a strong classifier with Multiple Kernel Boosting (MKB) is learned to calculate the strong top-down (STD) saliency map based on samples directly from the obtained multi-level WBU saliency maps. We finally integrate these two stage saliency maps from all levels together to highlight polyps. Experiment results achieve 0.818 recall for saliency calculation, validating the effectiveness of our method. Extensive experiments on public polyp datasets demonstrate that the proposed saliency algorithm performs favorably against state-of-the-art saliency methods to detect polyps.

  2. Unified approach to the study of light and heavy mesons in the frameworkof the vacuum-polarization-corrected potential model

    International Nuclear Information System (INIS)

    Barik, N.; Jena, S.N.

    1981-01-01

    Phenomenological evidence from meson spectroscopy is presented to support the view that a unified description of bound light- and heavy-quark systems is possible within the scope of a nonrelativistic-potential-model approach. The vacuum-polarization-corrected potential with its confinement part in the form of an approximately equal admixture of vector and scalar components is found to be a suitable one for the purpose. The overall systematics of the predictions based on this potential model for the meson masses, fine-hyperfine splittings, leptonic decay widths, and the Regge slopes are observed to be consistent with the premise that the forces between quarks and antiquarks are independent of the quark flavors

  3. Towards a unified treatment of Yang-Mills and Higgs fields

    International Nuclear Information System (INIS)

    Balakrishna, B.S.; Guersey, F.; Wali, K.C.

    1991-01-01

    Starting from a noncommutative algebra scrA of the form scrC direct-product scrM, where scrC is the algebra of smooth functions on space-time and scrM is the algebra of nxn Hermitian matrices, we construct an exterior algebra of differential forms over scrA. We use the one-forms of this algebra to describe Yang-Mills and Higgs fields on a similar footing and construct a Lagrangian from its two-forms. We show how, in the resulting geometrical description, a Higgs potential that leads to spontaneous symmetry breaking arises naturally. We discuss the application of this formalism to the bosonic sectors of the standard electroweak theory and a grand-unified model based on SU(5)direct-product U(1)

  4. Survey of meshless and generalized finite element methods: A unified approach

    Science.gov (United States)

    Babuška, Ivo; Banerjee, Uday; Osborn, John E.

    In the past few years meshless methods for numerically solving partial differential equations have come into the focus of interest, especially in the engineering community. This class of methods was essentially stimulated by difficulties related to mesh generation. Mesh generation is delicate in many situations, for instance, when the domain has complicated geometry; when the mesh changes with time, as in crack propagation, and remeshing is required at each time step; when a Lagrangian formulation is employed, especially with nonlinear PDEs. In addition, the need for flexibility in the selection of approximating functions (e.g., the flexibility to use non-polynomial approximating functions), has played a significant role in the development of meshless methods. There are many recent papers, and two books, on meshless methods; most of them are of an engineering character, without any mathematical analysis.In this paper we address meshless methods and the closely related generalized finite element methods for solving linear elliptic equations, using variational principles. We give a unified mathematical theory with proofs, briefly address implementational aspects, present illustrative numerical examples, and provide a list of references to the current literature.The aim of the paper is to provide a survey of a part of this new field, with emphasis on mathematics. We present proofs of essential theorems because we feel these proofs are essential for the understanding of the mathematical aspects of meshless methods, which has approximation theory as a major ingredient. As always, any new field is stimulated by and related to older ideas. This will be visible in our paper.

  5. Towards a unified description of the hydrogen bond network of liquid water: A dynamics based approach

    International Nuclear Information System (INIS)

    Ozkanlar, Abdullah; Zhou, Tiecheng; Clark, Aurora E.

    2014-01-01

    The definition of a hydrogen bond (H-bond) is intimately related to the topological and dynamic properties of the hydrogen bond network within liquid water. The development of a universal H-bond definition for water is an active area of research as it would remove many ambiguities in the network properties that derive from the fixed definition employed to assign whether a water dimer is hydrogen bonded. This work investigates the impact that an electronic-structure based definition, an energetic, and a geometric definition of the H-bond has upon both topological and dynamic network behavior of simulated water. In each definition, the use of a cutoff (either geometric or energetic) to assign the presence of a H-bond leads to the formation of transiently bonded or broken dimers, which have been quantified within the simulation data. The relative concentration of transient species, and their duration, results in two of the three definitions sharing similarities in either topological or dynamic features (H-bond distribution, H-bond lifetime, etc.), however no two definitions exhibit similar behavior for both classes of network properties. In fact, two networks with similar local network topology (as indicated by similar average H-bonds) can have dramatically different global network topology (as indicated by the defect state distributions) and altered H-bond lifetimes. A dynamics based correction scheme is then used to remove artificially transient H-bonds and to repair artificially broken bonds within the network such that the corrected network exhibits the same structural and dynamic properties for two H-bond definitions (the properties of the third definition being significantly improved). The algorithm described represents a significant step forward in the development of a unified hydrogen bond network whose properties are independent of the original hydrogen bond definition that is employed

  6. Novel approaches to epilepsy treatment

    DEFF Research Database (Denmark)

    Sørensen, Andreas T; Kokaia, Merab

    2013-01-01

    The aim of epilepsy treatment is to achieve complete seizure freedom. Nonetheless, numerous side effects and seizure resistance to antiepileptic drugs (AEDs) affecting about 30-40% of all patients are main unmet needs in today's epileptology. For this reason, novel approaches to treat epilepsy......, and inhibitory neurotransmitters. We also address new molecular-genetic approaches utilizing optogenetic technology. The therapeutic strategies presented herein are predominately aimed toward treatment of partial/focal epilepsies, but could also be envisaged for targeting key seizure propagation areas...... are highly needed. Herein, we highlight recent progress in stem-cell-based and gene transfer-based therapies in epilepsy according to findings in animal models and address their potential clinical application. Multiple therapeutic targets are described, including neuropeptides, neurotrophic factors...

  7. An unified approach for the design of focal-plane arrays in satellite communication

    NARCIS (Netherlands)

    Zamanifekri, A.; Smolders, A.B.

    2012-01-01

    The aim of this paper is to present a hybrid approach for designing focal plane arrays using commercially available software, considering the fact that the main trade-off in the EM simulation is the accuracy versus computational power. The presented approach is hybrid method based on FDTD/PO. The

  8. An enhanced unified uncertainty analysis approach based on first order reliability method with single-level optimization

    International Nuclear Information System (INIS)

    Yao, Wen; Chen, Xiaoqian; Huang, Yiyong; Tooren, Michel van

    2013-01-01

    In engineering, there exist both aleatory uncertainties due to the inherent variation of the physical system and its operational environment, and epistemic uncertainties due to lack of knowledge and which can be reduced with the collection of more data. To analyze the uncertain distribution of the system performance under both aleatory and epistemic uncertainties, combined probability and evidence theory can be employed to quantify the compound effects of the mixed uncertainties. The existing First Order Reliability Method (FORM) based Unified Uncertainty Analysis (UUA) approach nests the optimization based interval analysis in the improved Hasofer–Lind–Rackwitz–Fiessler (iHLRF) algorithm based Most Probable Point (MPP) searching procedure, which is computationally inhibitive for complex systems and may encounter convergence problem as well. Therefore, in this paper it is proposed to use general optimization solvers to search MPP in the outer loop and then reformulate the double-loop optimization problem into an equivalent single-level optimization (SLO) problem, so as to simplify the uncertainty analysis process, improve the robustness of the algorithm, and alleviate the computational complexity. The effectiveness and efficiency of the proposed method is demonstrated with two numerical examples and one practical satellite conceptual design problem. -- Highlights: ► Uncertainty analysis under mixed aleatory and epistemic uncertainties is studied. ► A unified uncertainty analysis method is proposed with combined probability and evidence theory. ► The traditional nested analysis method is converted to single level optimization for efficiency. ► The effectiveness and efficiency of the proposed method are testified with three examples

  9. A unified treatment of the non-relativistic and relativistic hydrogen atom: Pt. 2

    International Nuclear Information System (INIS)

    Swainson, R.A.; Drake, G.W.F.

    1991-01-01

    This is the second in a series of three papers in which it is shown how the radial part of non-relativistic and relativistic hydrogenic bound-state calculations involving the Green functions can be presented in a unified manner. In this paper the non-relativistic Green function is examined in detail; new functional forms are presented and a clear mathematical progression is show to link these and most other known forms. A linear transformation of the four radial parts of the relativistic Green function is given which allows for the presentation of this function as a simple generalization of the non-relativistic Green function. Thus, many properties of the non-relativistic Green function are shown to have simple relativistic generalizations. In particular, new recursion relations of the radial parts of both the non-relativistic and relativistic Green functions are presented, along with new expressions for the double Laplace transforms and recursion relations between the radial matrix elements. (author)

  10. Unified approach for estimating the probabilistic design S-N curves of three commonly used fatigue stress-life models

    International Nuclear Information System (INIS)

    Zhao Yongxiang; Wang Jinnuo; Gao Qing

    2001-01-01

    A unified approach, referred to as general maximum likelihood method, is presented for estimating probabilistic design S-N curves and their confidence bounds of the three commonly used fatigue stress-life models, namely three parameter, Langer and Basquin. The curves are described by a general form of mean and standard deviation S-N curves of the logarithm of fatigue life. Different from existent methods, i.e., the conventional method and the classical maximum likelihood method,present approach considers the statistical characteristics of whole test data. The parameters of the mean curve is firstly estimated by least square method and then, the parameters of the standard deviation curve is evaluated by mathematical programming method to be agreement with the maximum likelihood principle. Fit effects of the curves are assessed by fitted relation coefficient, total fitted standard error and the confidence bounds. Application to the virtual stress amplitude-crack initiation life data of a nuclear engineering material, Chinese 1Cr18Ni9Ti stainless steel pipe-weld metal, has indicated the validity of the approach to the S-N data where both S and N show the character of random variable. Practices to the two states of S-N data of Chinese 45 carbon steel notched specimens (k t = 2.0) have indicated the validity of present approach to the test results obtained respectively from group fatigue test and from maximum likelihood fatigue test. At the practices, it was revealed that in general the fit is best for the three-parameter model,slightly inferior for the Langer relation and poor for the Basquin equation. Relative to the existent methods, present approach has better fit. In addition, the possible non-conservative predictions of the existent methods, which are resulted from the influence of local statistical characteristics of the data, are also overcome by present approach

  11. Towards a Unified Approach to Safety and Security in Automotive Systems

    Science.gov (United States)

    Jesty, Peter H.; Ward, David D.

    At the time when IEC 61508 was being created, analogous work was also being done to harmonise security evaluation criteria. Although there was no cross-fertilisation between these two activities, the MISRA project did use the ITSEC evaluation criteria as the basis for its recommendations on the requirements for software at varying levels of integrity. This paper points out the advantages of this approach for safety engineers, and explains how it overcomes some of the difficulties that people now have in applying IEC 61508. It also shows how the approach can be used for other attributes such as electromagnetic compatibility.

  12. Unified approach to the entropy of an extremal rotating BTZ black hole: Thin shells and horizon limits

    Science.gov (United States)

    Lemos, José P. S.; Minamitsuji, Masato; Zaslavskii, Oleg B.

    2017-10-01

    Using a thin shell, the first law of thermodynamics, and a unified approach, we study the thermodymanics and find the entropy of a (2 +1 )-dimensional extremal rotating Bañados-Teitelbom-Zanelli (BTZ) black hole. The shell in (2 +1 ) dimensions, i.e., a ring, is taken to be circularly symmetric and rotating, with the inner region being a ground state of the anti-de Sitter spacetime and the outer region being the rotating BTZ spacetime. The extremal BTZ rotating black hole can be obtained in three different ways depending on the way the shell approaches its own gravitational or horizon radius. These ways are explicitly worked out. The resulting three cases give that the BTZ black hole entropy is either the Bekenstein-Hawking entropy, S =A/+ 4 G , or an arbitrary function of A+, S =S (A+) , where A+=2 π r+ is the area, i.e., the perimeter, of the event horizon in (2 +1 ) dimensions. We speculate that the entropy of an extremal black hole should obey 0 ≤S (A+)≤A/+ 4 G . We also show that the contributions from the various thermodynamic quantities, namely, the mass, the circular velocity, and the temperature, for the entropy in all three cases are distinct. This study complements the previous studies in thin shell thermodynamics and entropy for BTZ black holes. It also corroborates the results found for a (3 +1 )-dimensional extremal electrically charged Reissner-Nordström black hole.

  13. Social Learning Theory: Toward a Unified Approach of Pediatric Procedural Pain

    Science.gov (United States)

    Page, Lynn Olson; Blanchette, Jennifer A.

    2009-01-01

    Undermanaged procedural pain has been shown to have short and long term effects on children. While significant progress regarding empirically supported treatments has been made, theoretical bases for the development and management of procedural pain are lacking. This paper examines the role of social learning theory in our current understanding of…

  14. Development and application of a unified balancing approach with multiple constraints

    Science.gov (United States)

    Zorzi, E. S.; Lee, C. C.; Giordano, J. C.

    1985-01-01

    The development of a general analytic approach to constrained balancing that is consistent with past influence coefficient methods is described. The approach uses Lagrange multipliers to impose orbit and/or weight constraints; these constraints are combined with the least squares minimization process to provide a set of coupled equations that result in a single solution form for determining correction weights. Proper selection of constraints results in the capability to: (1) balance higher speeds without disturbing previously balanced modes, thru the use of modal trial weight sets; (2) balance off-critical speeds; and (3) balance decoupled modes by use of a single balance plane. If no constraints are imposed, this solution form reduces to the general weighted least squares influence coefficient method. A test facility used to examine the use of the general constrained balancing procedure and application of modal trial weight ratios is also described.

  15. Methods for extracting dose response curves from radiation therapy data. I. A unified approach

    International Nuclear Information System (INIS)

    Herring, D.F.

    1980-01-01

    This paper discusses an approach to fitting models to radiation therapy data in order to extract dose response curves for tumor local control and normal tissue damage. The approach is based on the method of maximum likelihood and is illustrated by several examples. A general linear logistic equation which leads to the Ellis nominal standard dose (NSD) equation is discussed; the fit of this equation to experimental data for mouse foot skin reactions produced by fractionated irradiation is described. A logistic equation based on the concept that normal tissue reactions are associated with the surviving fraction of cells is also discussed, and the fit of this equation to the same set of mouse foot skin reaction data is also described. These two examples illustrate the importance of choosing a model based on underlying mechanisms when one seeks to attach biological significance to a model's parameters

  16. Transdiagnostic treatment of bipolar disorder and comorbid anxiety using the Unified Protocol for Emotional Disorders: A pilot feasibility and acceptability trial.

    Science.gov (United States)

    Ellard, Kristen K; Bernstein, Emily E; Hearing, Casey; Baek, Ji Hyun; Sylvia, Louisa G; Nierenberg, Andrew A; Barlow, David H; Deckersbach, Thilo

    2017-09-01

    Comorbid anxiety in bipolar disorder (BD) is associated with greater illness severity, reduced treatment response, and greater impairment. Treating anxiety in the context of BD is crucial for improving illness course and outcomes. The current study examined the feasibility, acceptability and preliminary efficacy of the Unified Protocol (UP), a transdiagnostic cognitive behavioral therapy, as an adjunctive treatment to pharmacotherapy for BD and comorbid anxiety disorders. Twenty-nine patients with BD and at least one comorbid anxiety disorder were randomized to pharmacotherapy treatment-as-usual (TAU) or TAU with 18 sessions of the UP (UP+TAU). All patients completed assessments every four weeks to track symptoms, functioning, emotion regulation and temperament. Linear mixed-model regressions were conducted to track symptom changes over time and to examine the relationship between emotion-related variables and treatment response. Satisfaction ratings were equivalent for both treatment groups. Patients in the UP+TAU group evidenced significantly greater reductions over time in anxiety and depression symptoms (Cohen's d's>0.80). Baseline levels of neuroticism, perceived affective control, and emotion regulation ability predicted magnitude of symptom change for the UP+TAU group only. Greater change in perceived control of emotions and emotion regulation skills predicted greater change in anxiety related symptoms. This was a pilot feasibility and acceptability trial; results should be interpreted with caution. Treatment with the UP+TAU was rated high in patient satisfaction, and resulted in significantly greater improvement on indices of anxiety and depression relative to TAU. This suggests that the UP may be a feasible treatment approach for BD with comorbid anxiety. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Theoretical Approaches in Evolutionary Ecology: Environmental Feedback as a Unifying Perspective.

    Science.gov (United States)

    Lion, Sébastien

    2018-01-01

    Evolutionary biology and ecology have a strong theoretical underpinning, and this has fostered a variety of modeling approaches. A major challenge of this theoretical work has been to unravel the tangled feedback loop between ecology and evolution. This has prompted the development of two main classes of models. While quantitative genetics models jointly consider the ecological and evolutionary dynamics of a focal population, a separation of timescales between ecology and evolution is assumed by evolutionary game theory, adaptive dynamics, and inclusive fitness theory. As a result, theoretical evolutionary ecology tends to be divided among different schools of thought, with different toolboxes and motivations. My aim in this synthesis is to highlight the connections between these different approaches and clarify the current state of theory in evolutionary ecology. Central to this approach is to make explicit the dependence on environmental dynamics of the population and evolutionary dynamics, thereby materializing the eco-evolutionary feedback loop. This perspective sheds light on the interplay between environmental feedback and the timescales of ecological and evolutionary processes. I conclude by discussing some potential extensions and challenges to our current theoretical understanding of eco-evolutionary dynamics.

  18. Improvement in quality of life and sexual functioning in a comorbid sample after the unified protocol transdiagnostic group treatment.

    Science.gov (United States)

    de Ornelas Maia, Ana Claudia Corrêa; Sanford, Jenny; Boettcher, Hannah; Nardi, Antonio E; Barlow, David

    2017-10-01

    Patients with multiple mental disorders often experience sexual dysfunction and reduced quality of life. The unified protocol (UP) is a transdiagnostic treatment for emotional disorders that has the potential to improve quality of life and sexual functioning via improved emotion management. The present study evaluates changes in quality of life and sexual functioning in a highly comorbid sample treated with the UP in a group format. Forty-eight patients were randomly assigned to either a UP active-treatment group or a medication-only control group. Treatment was delivered in 14 sessions over the course of 4 months. Symptoms of anxiety and depression were assessed using the Beck Anxiety Inventory and Beck Depression Inventory. Sexual functioning was assessed by the Arizona Sexual Experience Scale (ASEX), and quality of life was assessed by the World Health Organization Quality of Life-BREF scale (WHOQOL-BREF). Quality of life, anxiety and depression all significantly improved among participants treated with the UP. Some improvement in sexual functioning was also noted. The results support the efficacy of the UP in improving quality of life and sexual functioning in comorbid patients. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. A Unified Approach to the Analysis of Multicarrier DS-CDMA over Nakagami-$M$ Fading Channels

    OpenAIRE

    Yang, L-L.; Hanzo, L.

    2001-01-01

    A class of unified multicarrier DS-CDMA (MC DS-CDMA) schemes is defined and its performance is considered over multipath Nakagami-$M$ fading channels. The spacing between two adjacent subcarriers of the unified MC DS-CDMA scheme is a variable, allowing us to gain insight into the effects of the spacing on the bit error rate (BER) performance of MC DS-CDMA systems. This unified MC DS-CDMA scheme includes the subclasses of multitone DS-CDMA and orthogonal MC DS-CDMA as special cases. The optimu...

  20. A unified aggregation and relaxation approach for stress-constrained topology optimization

    DEFF Research Database (Denmark)

    Verbart, Alexander; Langelaar, Matthijs; Keulen, Fred van

    2017-01-01

    design-independent set of constraints. The next step is to perform constraint aggregation over the reformulated local constraints using a lower bound aggregation function. We demonstrate that this approach concurrently aggregates the constraints and relaxes the feasible domain, thereby making singular...... optima accessible. The main advantage is that no separate constraint relaxation techniques are necessary, which reduces the parameter dependence of the problem. Furthermore, there is a clear relationship between the original feasible domain and the perturbed feasible domain via this aggregation parameter....

  1. A unified approach to building accelerator simulation software for the SSC

    International Nuclear Information System (INIS)

    Paxson, V.; Aragon, C.; Peggs, S.; Saltmarsh, C.; Schachinger, L.

    1989-03-01

    To adequately simulate the physics and control of a complex accelerator requires a substantial number of programs which must present a uniform interface to both the user and the internal representation of the accelerator. If these programs are to be truly modular, so that their use can be orchestrated as needed, the specification of both their graphical and data interfaces must be carefully designed. We describe the state of such SSC simulation software, with emphasis on addressing these uniform interface needs by using a standardized data set format and object-oriented approaches to graphics and modeling. 12 refs

  2. Link Performance Analysis and monitoring - A unified approach to divergent requirements

    Science.gov (United States)

    Thom, G. A.

    Link Performance Analysis and real-time monitoring are generally covered by a wide range of equipment. Bit Error Rate testers provide digital link performance measurements but are not useful during real-time data flows. Real-time performance monitors utilize the fixed overhead content but vary widely from format to format. Link quality information is also present from signal reconstruction equipment in the form of receiver AGC, bit synchronizer AGC, and bit synchronizer soft decision level outputs, but no general approach to utilizing this information exists. This paper presents an approach to link tests, real-time data quality monitoring, and results presentation that utilizes a set of general purpose modules in a flexible architectural environment. The system operates over a wide range of bit rates (up to 150 Mbs) and employs several measurement techniques, including P/N code errors or fixed PCM format errors, derived real-time BER from frame sync errors, and Data Quality Analysis derived by counting significant sync status changes. The architecture performs with a minimum of elements in place to permit a phased update of the user's unit in accordance with his needs.

  3. Fidelity Susceptibility Made Simple: A Unified Quantum Monte Carlo Approach

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2015-07-01

    Full Text Available The fidelity susceptibility is a general purpose probe of phase transitions. With its origin in quantum information and in the differential geometry perspective of quantum states, the fidelity susceptibility can indicate the presence of a phase transition without prior knowledge of the local order parameter, as well as reveal the universal properties of a critical point. The wide applicability of the fidelity susceptibility to quantum many-body systems is, however, hindered by the limited computational tools to evaluate it. We present a generic, efficient, and elegant approach to compute the fidelity susceptibility of correlated fermions, bosons, and quantum spin systems in a broad range of quantum Monte Carlo methods. It can be applied to both the ground-state and nonzero-temperature cases. The Monte Carlo estimator has a simple yet universal form, which can be efficiently evaluated in simulations. We demonstrate the power of this approach with applications to the Bose-Hubbard model, the spin-1/2 XXZ model, and use it to examine the hypothetical intermediate spin-liquid phase in the Hubbard model on the honeycomb lattice.

  4. A unified approach for suppressing sidelobes arising in the spectral response of rugate filters

    International Nuclear Information System (INIS)

    Abo-Zahhad, M.; Bataineh, M.

    2000-01-01

    This paper suggests a universal approach to reduce the side lobes which usually appear at both sides of a stop band of a ru gate filter. Both quin tic matching layers and anodization functions are to used to improve the filter's response. The proposed technique could be used to control the ripples level by properly choosing the refractive index profile after amending it to include mat aching layers and/or modulating its profile with a slowly varying anodization (or ta perine) function. Two illustrative examples are given to demonstrate the robustness of the proposed technique. The given examples suggest that combining both effects on the index of refraction profile lead to the lowest possible ripple level. A multichannel filter response is obtained by wavelet cons traction of the refractive index profile with potential applications in multimode lasers and wavelength division multiple xin networks. The obtained results demonstrate the applicability of the adopted approach to design ripple free ru gate filters. The extension to stack filters and other wave guiding structures are also visible. (authors). 14 refs., 8 figs

  5. A unified approach to linking experimental, statistical and computational analysis of spike train data.

    Directory of Open Access Journals (Sweden)

    Liang Meng

    Full Text Available A fundamental issue in neuroscience is how to identify the multiple biophysical mechanisms through which neurons generate observed patterns of spiking activity. In previous work, we proposed a method for linking observed patterns of spiking activity to specific biophysical mechanisms based on a state space modeling framework and a sequential Monte Carlo, or particle filter, estimation algorithm. We have shown, in simulation, that this approach is able to identify a space of simple biophysical models that were consistent with observed spiking data (and included the model that generated the data, but have yet to demonstrate the application of the method to identify realistic currents from real spike train data. Here, we apply the particle filter to spiking data recorded from rat layer V cortical neurons, and correctly identify the dynamics of an slow, intrinsic current. The underlying intrinsic current is successfully identified in four distinct neurons, even though the cells exhibit two distinct classes of spiking activity: regular spiking and bursting. This approach--linking statistical, computational, and experimental neuroscience--provides an effective technique to constrain detailed biophysical models to specific mechanisms consistent with observed spike train data.

  6. A unified approach for squeal instability analysis of disc brakes with two types of random-fuzzy uncertainties

    Science.gov (United States)

    Lü, Hui; Shangguan, Wen-Bin; Yu, Dejie

    2017-09-01

    Automotive brake systems are always subjected to various types of uncertainties and two types of random-fuzzy uncertainties may exist in the brakes. In this paper, a unified approach is proposed for squeal instability analysis of disc brakes with two types of random-fuzzy uncertainties. In the proposed approach, two uncertainty analysis models with mixed variables are introduced to model the random-fuzzy uncertainties. The first one is the random and fuzzy model, in which random variables and fuzzy variables exist simultaneously and independently. The second one is the fuzzy random model, in which uncertain parameters are all treated as random variables while their distribution parameters are expressed as fuzzy numbers. Firstly, the fuzziness is discretized by using α-cut technique and the two uncertainty analysis models are simplified into random-interval models. Afterwards, by temporarily neglecting interval uncertainties, the random-interval models are degraded into random models, in which the expectations, variances, reliability indexes and reliability probabilities of system stability functions are calculated. And then, by reconsidering the interval uncertainties, the bounds of the expectations, variances, reliability indexes and reliability probabilities are computed based on Taylor series expansion. Finally, by recomposing the analysis results at each α-cut level, the fuzzy reliability indexes and probabilities can be obtained, by which the brake squeal instability can be evaluated. The proposed approach gives a general framework to deal with both types of random-fuzzy uncertainties that may exist in the brakes and its effectiveness is demonstrated by numerical examples. It will be a valuable supplement to the systematic study of brake squeal considering uncertainty.

  7. A Unified approach for nucleon knock-out, coherent and incoherent pion production in neutrino interactions with nuclei

    CERN Document Server

    Martini, M.; Chanfray, G.; Marteau, J.

    2009-01-01

    We present a theory of neutrino interactions with nuclei aimed at the description of the partial cross-sections, namely quasi-elastic and multi-nucleon emission, coherent and incoherent single pion production. For this purpose, we use the theory of nuclear responses treated in the random phase approximation, which allows a unified description of these channels. It is particularly suited for the coherent pion production where collective effects are important whereas they are moderate in the other channels. We also study the evolution of the neutrino cross-sections with the mass number from carbon to calcium. We compare our approach to the available neutrino experimental data on carbon. We put a particular emphasis on the multi-nucleon channel, which at present is not easily distinguishable from the quasi-elastic events. This component turns out to be quite relevant for the interpretation of experiments (K2K, MiniBooNE, SciBooNE). It can account in particular for the unexpected behavior of the quasi-elastic cro...

  8. A unified approach to the design of advanced proportional-integral-derivative controllers for time-delay processes

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Moonyong [Yeungnam University, Gyeongsan (Korea, Republic of); Vu, Truong Nguyen Luan [University of Technical Education of Ho Chi Minh City, Ho Chi Minh (China)

    2013-03-15

    A unified approach for the design of proportional-integral-derivative (PID) controllers cascaded with first-order lead-lag filters is proposed for various time-delay processes. The proposed controller’s tuning rules are directly derived using the Padé approximation on the basis of internal model control (IMC) for enhanced stability against disturbances. A two-degrees-of-freedom (2DOF) control scheme is employed to cope with both regulatory and servo problems. Simulation is conducted for a broad range of stable, integrating, and unstable processes with time delays. Each simulated controller is tuned to have the same degree of robustness in terms of maximum sensitivity (Ms). The results demonstrate that the proposed controller provides superior disturbance rejection and set-point tracking when compared with recently published PID-type controllers. Controllers’ robustness is investigated through the simultaneous introduction of perturbation uncertainties to all process parameters to obtain worst-case process-model mismatch. The process-model mismatch simulation results demonstrate that the proposed method consistently affords superior robustness.

  9. Semihard interactions in nuclear collisions based on a unified approach to high energy scattering

    International Nuclear Information System (INIS)

    Drescher, H.J.; Hladik, M.; Werner, K.; Ostapchenko, S.; Centre National de la Recherche Scientifique, 44 - Nantes

    1998-01-01

    Our ultimate goal is the construction of a model for interactions of two nuclei in the energy range between several tens of GeV up to several TeV per nucleon in the centre-of-mass system. Such nuclear collisions are very complex, being composed of many components, and therefore some strategy is needed to construct a reliable model. The central point of our approach is the hypothesis, that the behavior of high energy interactions is universal (universality hypothesis). A model for nuclear interactions in a modular fashion is proposed. The individual modules, based on the universality hypothesis, are identified as building blocks for more elementary interactions (like e + e - , lepton-proton), and can therefore be studied in a much simpler context. With these building blocks under control, a quite reliable model is developed for nucleus-nucleus scattering, providing in particular very useful tests for the complicated numerical procedures using Monte Carlo techniques. (author)

  10. Towards a unified fronthaul-backhaul data plane for 5G The 5G-Crosshaul project approach

    OpenAIRE

    Cavaliere, Fabio; Iovanna, Paola; Mangues-Bafalluy, Josep; Baranda, Jorge; Núñez-Martínez, José; Lin, Kun-Yi; Chang, Hsien-Wen; Chanclou, Philippe; Farkas, Peter; Gomes, Jessé; Cominardi, Luca; Mourad, Alain; De La Oliva, Antonio; Hernández, José Alberto; Larrabeiti, David

    2017-01-01

    The paper presents a study of key aspects in the design of a flexible unified data plane capable of integrating both fronthaul and backhaul transport in future 5G systems. In this study, we first review candidate access and multiplexing technologies from the state of the art and assess their capability to support legacy and new fronthaul and backhaul traffic. We then propose a new design framework for the targeted flexible unified data plane, featuring a primary packet-switching path supporte...

  11. High-precision optical systems with inexpensive hardware: a unified alignment and structural design approach

    Science.gov (United States)

    Winrow, Edward G.; Chavez, Victor H.

    2011-09-01

    High-precision opto-mechanical structures have historically been plagued by high costs for both hardware and the associated alignment and assembly process. This problem is especially true for space applications where only a few production units are produced. A methodology for optical alignment and optical structure design is presented which shifts the mechanism of maintaining precision from tightly toleranced, machined flight hardware to reusable, modular tooling. Using the proposed methodology, optical alignment error sources are reduced by the direct alignment of optics through their surface retroreflections (pips) as seen through a theodolite. Optical alignment adjustments are actualized through motorized, sub-micron precision actuators in 5 degrees of freedom. Optical structure hardware costs are reduced through the use of simple shapes (tubes, plates) and repeated components. This approach produces significantly cheaper hardware and more efficient assembly without sacrificing alignment precision or optical structure stability. The design, alignment plan and assembly of a 4" aperture, carbon fiber composite, Schmidt-Cassegrain concept telescope is presented.

  12. PyMVPA: a unifying approach to the analysis of neuroscientific data

    Directory of Open Access Journals (Sweden)

    Michael Hanke

    2009-02-01

    Full Text Available The Python programming language is steadily increasing in popularity as the language of choice for scientific computing. The ability of this scripting environment to access a huge code base in various languages, combined with its syntactical simplicity, make it the ideal tool for implementing and sharing ideas among scientists from numerous fields and with heterogeneous methodological backgrounds. The recent rise of reciprocal interest between the machine learning and neuroscience communities is an example of the desire for an inter-disciplinary transfer of computational methods that can benefit from a Python-based framework. For many years, a large fraction of both research communities have addressed, almost independently, very high-dimensional problems with almost completely non-overlapping methods. However, a number of recently published studies that applied machine learning methods to neuroscience research questions attracted a lot of attention from researchers from both fields, as well as the general public, and showed that this approach can provide novel and fruitful insights into the functioning of the brain. In this article we show how PyMVPA, a specialized Python framework for machine-learning based data analysis, can help to facilitate this inter-disciplinary technology transfer by providing a single interface to a wide array of machine-learning libraries and neural data-processing methods. We demonstrate the general applicability and power of PyMVPA via analyses of a number of neural data modalities, including fMRI, EEG, MEG, and extracellular recordings.

  13. A unified approach for development of Urdu Corpus for OCR and demographic purpose

    Science.gov (United States)

    Choudhary, Prakash; Nain, Neeta; Ahmed, Mushtaq

    2015-02-01

    This paper presents a methodology for the development of an Urdu handwritten text image Corpus and application of Corpus linguistics in the field of OCR and information retrieval from handwritten document. Compared to other language scripts, Urdu script is little bit complicated for data entry. To enter a single character it requires a combination of multiple keys entry. Here, a mixed approach is proposed and demonstrated for building Urdu Corpus for OCR and Demographic data collection. Demographic part of database could be used to train a system to fetch the data automatically, which will be helpful to simplify existing manual data-processing task involved in the field of data collection such as input forms like Passport, Ration Card, Voting Card, AADHAR, Driving licence, Indian Railway Reservation, Census data etc. This would increase the participation of Urdu language community in understanding and taking benefit of the Government schemes. To make availability and applicability of database in a vast area of corpus linguistics, we propose a methodology for data collection, mark-up, digital transcription, and XML metadata information for benchmarking.

  14. A Unified Experimental Approach for Estimation of Irrigationwater and Nitrate Leaching in Tree Crops

    Science.gov (United States)

    Hopmans, J. W.; Kandelous, M. M.; Moradi, A. B.

    2014-12-01

    Groundwater quality is specifically vulnerable in irrigated agricultural lands in California and many other(semi-)arid regions of the world. The routine application of nitrogen fertilizers with irrigation water in California is likely responsible for the high nitrate concentrations in groundwater, underlying much of its main agricultural areas. To optimize irrigation/fertigation practices, it is essential that irrigation and fertilizers are applied at the optimal concentration, place, and time to ensure maximum root uptake and minimize leaching losses to the groundwater. The applied irrigation water and dissolved fertilizer, as well as root growth and associated nitrate and water uptake, interact with soil properties and fertilizer source(s) in a complex manner that cannot easily be resolved. It is therefore that coupled experimental-modeling studies are required to allow for unraveling of the relevant complexities that result from typical field-wide spatial variations of soil texture and layering across farmer-managed fields. We present experimental approaches across a network of tree crop orchards in the San Joaquin Valley, that provide the necessary soil data of soil moisture, water potential and nitrate concentration to evaluate and optimize irrigation water management practices. Specifically, deep tensiometers were used to monitor in-situ continuous soil water potential gradients, for the purpose to compute leaching fluxes of water and nitrate at both the individual tree and field scale.

  15. A unified approach for EIT imaging of regional overdistension and atelectasis in acute lung injury.

    Science.gov (United States)

    Gómez-Laberge, Camille; Arnold, John H; Wolf, Gerhard K

    2012-03-01

    Patients with acute lung injury or acute respiratory distress syndrome (ALI/ARDS) are vulnerable to ventilator-induced lung injury. Although this syndrome affects the lung heterogeneously, mechanical ventilation is not guided by regional indicators of potential lung injury. We used electrical impedance tomography (EIT) to estimate the extent of regional lung overdistension and atelectasis during mechanical ventilation. Techniques for tidal breath detection, lung identification, and regional compliance estimation were combined with the Graz consensus on EIT lung imaging (GREIT) algorithm. Nine ALI/ARDS patients were monitored during stepwise increases and decreases in airway pressure. Our method detected individual breaths with 96.0% sensitivity and 97.6% specificity. The duration and volume of tidal breaths erred on average by 0.2 s and 5%, respectively. Respiratory system compliance from EIT and ventilator measurements had a correlation coefficient of 0.80. Stepwise increases in pressure could reverse atelectasis in 17% of the lung. At the highest pressures, 73% of the lung became overdistended. During stepwise decreases in pressure, previously-atelectatic regions remained open at sub-baseline pressures. We recommend that the proposed approach be used in collaborative research of EIT-guided ventilation strategies for ALI/ARDS.

  16. Permutation-based inference for the AUC: A unified approach for continuous and discontinuous data.

    Science.gov (United States)

    Pauly, Markus; Asendorf, Thomas; Konietschke, Frank

    2016-11-01

    We investigate rank-based studentized permutation methods for the nonparametric Behrens-Fisher problem, that is, inference methods for the area under the ROC curve. We hereby prove that the studentized permutation distribution of the Brunner-Munzel rank statistic is asymptotically standard normal, even under the alternative. Thus, incidentally providing the hitherto missing theoretical foundation for the Neubert and Brunner studentized permutation test. In particular, we do not only show its consistency, but also that confidence intervals for the underlying treatment effects can be computed by inverting this permutation test. In addition, we derive permutation-based range-preserving confidence intervals. Extensive simulation studies show that the permutation-based confidence intervals appear to maintain the preassigned coverage probability quite accurately (even for rather small sample sizes). For a convenient application of the proposed methods, a freely available software package for the statistical software R has been developed. A real data example illustrates the application. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Radially and azimuthally dependent resonance self-shielding treatment for general multi-region geometry based on a unified theory

    International Nuclear Information System (INIS)

    Koike, Hiroki; Kirimura, Kazuki; Yamaji, Kazuya; Kosaka, Shinya; Yamamoto, Akio

    2018-01-01

    A unified resonance self-shielding method, which can treat general sub-divided fuel regions, is developed for lattice physics calculations in reactor physics field. In a past study, a hybrid resonance treatment has been developed by theoretically integrating equivalence theory and ultra-fine-group slowing-down calculation. It can be applied to a wide range of neutron spectrum conditions including low moderator density ranges in severe accident states, as long as each fuel region is not sub-divided. In order to extend the method for radially and azimuthally sub-divided multi-region geometry, a new resonance treatment is established by incorporating the essence of sub-group method. The present method is composed of two-step flux calculation, i.e. 'coarse geometry + fine energy' (first step) and 'fine geometry + coarse energy' (second step) calculations. The first step corresponds to a hybrid model of the equivalence theory and the ultra-fine-group calculation, and the second step corresponds to the sub-group method. From the verification results, effective cross-sections by the new method show good agreement with the continuous energy Monte-Carlo results for various multi-region geometries including non-uniform fuel compositions and temperature distributions. The present method can accurately generate effective cross-sections with short computation time in general lattice physics calculations. (author)

  18. A unified approach for proportional-integral-derivative controller design for time delay processes

    International Nuclear Information System (INIS)

    Shamsuzzoha, Mohammad

    2015-01-01

    An analytical design method for PI/PID controller tuning is proposed for several types of processes with time delay. A single tuning formula gives enhanced disturbance rejection performance. The design method is based on the IMC approach, which has a single tuning parameter to adjust the performance and robustness of the controller. A simple tuning formula gives consistently better performance as compared to several well-known methods at the same degree of robustness for stable and integrating process. The performance of the unstable process has been compared with other recently published methods which also show significant improvement in the proposed method. Furthermore, the robustness of the controller is investigated by inserting a perturbation uncertainty in all parameters simultaneously, again showing comparable results with other methods. An analysis has been performed for the uncertainty margin in the different process parameters for the robust controller design. It gives the guidelines of the M s setting for the PI controller design based on the process parameters uncertainty. For the selection of the closed-loop time constant, (τ c ), a guideline is provided over a broad range of θ/τ ratios on the basis of the peak of maximum uncertainty (M s ). A comparison of the IAE has been conducted for the wide range of θ/τ ratio for the first order time delay process. The proposed method shows minimum IAE in compared to SIMC, while Lee et al. shows poor disturbance rejection in the lag dominant process. In the simulation study, the controllers were tuned to have the same degree of robustness by measuring the M s , to obtain a reasonable comparison

  19. Towards an unified microscopic approach of the description of the nuclear structure and reaction

    International Nuclear Information System (INIS)

    Hoang, Sy Than

    2009-09-01

    This thesis contains 3 main parts. The first one: nuclear matter. The motivation of the study is to establish a link between the bare nucleon-nucleon interaction and nuclear matter properties. The properties of nuclear matter are examined using finite range effective interactions either derived from the Brueckner theory or determined in a purely phenomenological way. Skyrme-type interactions are also used for comparison. We have focused our discussion on several main aspects: the pressure ins symmetric nuclear matter and in neutron matter, the density dependence of the symmetric energy S and the nuclear matter incompressibility. The second part: the structure of finite nuclei and of the inner crust of neutrons stars. We present the non-relativistic HF and HF-BCS approaches in coordinate representation using finite-range density-dependent interactions in both the mean field and pairing channels. An iterative scheme is used for solving the integral-differential HF equations. We have studied the doubly magic nuclei, the Sn isotopes and the possible occurrence of bubble structures in the nuclei O 22 , Si 34 , Ar 46 and Ar 68 . We have also examined the different zones of the inner crust of neutron stars. The third part: nuclear reactions. Using the same effective interactions derived from the Brueckner theory we have performed a coupled channel analysis of (p,n) charge exchange reactions at 35 and 45 MeV incident energies on Ca 48 , Zr 90 , Sn 120 and Pb 208 targets leading to isobaric analog states. (A.C.)

  20. A Unified Approach for Reporting ARM Measurement Uncertainties Technical Report: Updated in 2016

    Energy Technology Data Exchange (ETDEWEB)

    Sisterson, Douglas [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-15

    The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility is observationally based, and quantifying the uncertainty of its measurements is critically important. With over 300 widely differing instruments providing over 2,500 datastreams, concise expression of measurement uncertainty is quite challenging. ARM currently provides data and supporting metadata (information about the data or data quality) to its users through several sources. Because the continued success of the ARM Facility depends on the known quality of its measurements, ARM relies on Instrument Mentors and the ARM Data Quality Office to ensure, assess, and report measurement quality. Therefore, an easily accessible, well-articulated estimate of ARM measurement uncertainty is needed. This report is a continuation of the work presented by Campos and Sisterson (2015) and provides additional uncertainty information from instruments not available in their report. As before, a total measurement uncertainty has been calculated as a function of the instrument uncertainty (calibration factors), the field uncertainty (environmental factors), and the retrieval uncertainty (algorithm factors). This study will not expand on methods for computing these uncertainties. As before, it will focus on the practical identification, characterization, and inventory of the measurement uncertainties already available to the ARM community through the ARM Instrument Mentors and their ARM instrument handbooks. This study continues the first steps towards reporting ARM measurement uncertainty as: (1) identifying how the uncertainty of individual ARM measurements is currently expressed, (2) identifying a consistent approach to measurement uncertainty, and then (3) reclassifying ARM instrument measurement uncertainties in a common framework.

  1. Partial information decomposition as a unified approach to the specification of neural goal functions.

    Science.gov (United States)

    Wibral, Michael; Priesemann, Viola; Kay, Jim W; Lizier, Joseph T; Phillips, William A

    2017-03-01

    In many neural systems anatomical motifs are present repeatedly, but despite their structural similarity they can serve very different tasks. A prime example for such a motif is the canonical microcircuit of six-layered neo-cortex, which is repeated across cortical areas, and is involved in a number of different tasks (e.g. sensory, cognitive, or motor tasks). This observation has spawned interest in finding a common underlying principle, a 'goal function', of information processing implemented in this structure. By definition such a goal function, if universal, cannot be cast in processing-domain specific language (e.g. 'edge filtering', 'working memory'). Thus, to formulate such a principle, we have to use a domain-independent framework. Information theory offers such a framework. However, while the classical framework of information theory focuses on the relation between one input and one output (Shannon's mutual information), we argue that neural information processing crucially depends on the combination of multiple inputs to create the output of a processor. To account for this, we use a very recent extension of Shannon Information theory, called partial information decomposition (PID). PID allows to quantify the information that several inputs provide individually (unique information), redundantly (shared information) or only jointly (synergistic information) about the output. First, we review the framework of PID. Then we apply it to reevaluate and analyze several earlier proposals of information theoretic neural goal functions (predictive coding, infomax and coherent infomax, efficient coding). We find that PID allows to compare these goal functions in a common framework, and also provides a versatile approach to design new goal functions from first principles. Building on this, we design and analyze a novel goal function, called 'coding with synergy', which builds on combining external input and prior knowledge in a synergistic manner. We suggest that

  2. The Pan-African Rabies Control Network (PARACON): A unified approach to eliminating canine rabies in Africa.

    Science.gov (United States)

    Scott, T P; Coetzer, A; de Balogh, K; Wright, N; Nel, L H

    2015-12-01

    Even though Africa has the highest per capita death rate from rabies of any continent, and the disease is almost entirely transmitted by the bites of rabid dogs, there has been no coordinated pan-African approach to controlling canine rabies. In order to attain an inclusive and unified network, the Pan-African Rabies Control Network (PARACON) was established in 2014. By following the 'One Health' concept, which involves close coordination between animal and human health sectors across national, regional and continental levels, PARACON will provide a platform to facilitate and promote coordinated and sustainable control strategies and programmes. Meetings will take place at regular intervals and will be centred on the involvement by key focal persons from the medical and veterinary sectors. The inaugural meeting was held in South Africa in June, 2015 and was focused around interactive discussions and workshops, whilst updating country representatives on the tools available to aid them in developing and implementing sustainable rabies intervention strategies. Experts from various global organizations, institutions and industry participated in the discussions and shared their experience and expertise. The workshops focused on the latest format of the Rabies Blueprint platform (www.rabiesblueprint.com), which in the broadest sense assists with control and elimination campaigns, including educational and advocacy drives, improvement of surveillance and diagnosis and the systematic monitoring of progress. Together with the Stepwise Approach towards Rabies Elimination, the Blueprint is a planning tool to help countries free themselves from canine-transmitted rabies. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Towards an unified microscopic approach of the description of the nuclear structure and reaction

    International Nuclear Information System (INIS)

    Hoang, Sy-Than

    2009-01-01

    This thesis contains 3 main parts: 1. Nuclear matter: The properties of nuclear matter are examined using finite range effective interactions, either derived from the Brueckner theory (M3Y-type interactions) or determined in a purely phenomenological way (Gogny-type interactions). Skyrme-type interactions are also used for comparison. The motivation of the study is to establish a link between the bare NN interaction and nuclear matter properties via the effective Brueckner G-matrix parameterized in the M3Y form. We have concentrated our discussion on several main aspects: the pressure in symmetric nuclear matter and in neutron matter, the density dependence of the symmetry energy S, the neutron star cooling, and the nuclear matter incompressibility for the symmetric and asymmetric nuclear matter. 2. Structure of finite nuclei and of the inner crust of neutron stars: We present the non-relativistic HF and HF-BCS approaches in coordinate representation using finite-range density-dependent interactions in both the mean field and pairing channels. The method for solving the HF equations in coordinate space is presented. We limit the study to the spherical symmetry case. An iterative scheme is used for solving the integro-differential HF equations. We adopt the method of Brueckner-Gammel-Weizner which is free of poles in the local equivalent potentials, in contrast to the usually used Vautherin-Veneroni method. Alternatively, we have developed a method using a basis of spherical Bessel functions. The latter method is useful for treating systems containing many nucleons in large boxes like the Wigner-Seitz (WS) cells of the neutron star inner crust. We have thus studied, using the effective interactions mentioned above, the doubly magic nuclei, the Sn isotopes, and the possible occurrence of bubble structures in the nuclei 22 O, 34 Si, 46 Ar and 68 Ar. We also present for the first time a study of Wigner-Seitz cells in the inner crust of neutron stars using finite range

  4. Cromatografia unificada Unified chromatography

    Directory of Open Access Journals (Sweden)

    Carin von Mühlen

    2004-10-01

    Full Text Available The scope of this study encompasses an overview of the principles of unified chromatography as well as the principles of chromatographic techniques as applied to unified systems, which include gas chromatography, liquid chromatography, supercritical fluid chromatography, high temperature and high pressure liquid chromatography, micro-liquid chromatography, enhanced fluidity chromatography, and solvating gas chromatography. Theoretical considerations and individual instrumental parameters such as mobile phase, sample introduction system, columns, and detection system are also discussed. Future applications of this separation approach are discussed.

  5. Unified treatment for accurate and fast evaluation of the Fermi–Dirac functions

    International Nuclear Information System (INIS)

    Guseinov, I. I.; Mamedov, B. A.

    2010-01-01

    A new analytical approach to the computation of the Fermi-Dirac (FD) functions is presented, which was suggested by previous experience with various algorithms. Using the binomial expansion theorem, these functions are expressed through the binomial coefficients and familiar incomplete Gamma functions. This simplification and the use of the memory of the computer for the calculation of binomial coefficients may extend the limits to large arguments for users and result in speedier calculation, should such limits be required in practice. Some numerical results are presented for significant mapping examples and they are briefly discussed. (general)

  6. Unifying Abstractions

    DEFF Research Database (Denmark)

    Torgersen, Mads

    This thesis presents the RUNE language, a semantic construction of related and tightly coupled programming constructs presented in the shape of a programming language. The major contribution is the succesfull design of a highly unified and general programming model, capable of expressing some of ...... a unified name declaration mechanism. The resulting expressiveness allows for argument covariance, dependent types and module types, plus a solution to the so-called expression problem of two way extensibility in object-oriented languages....... of the most complex type relations put forth in type systems research, without compromising such fundamental qualities as conceptuality, modularity and static typing. While many new constructs and unifications are put forth  to substantiate their conceptual validity, type rules are given to support...

  7. Why unify

    International Nuclear Information System (INIS)

    Georgi, H.

    1980-01-01

    Unified gauge theories such as SU(5) of particle interactions are built on the colour SU(3) and SU(2) x U(1) gauge theories which apparently describe strong and weak and electromagnetic interactions at distances as small as 10 -16 cm. In this article the classical reasons for going beyond SU(3)xSU(2)xU(1) to a fully unified theory such as SU(5) are reviewed, and a new reason formulated. A class of imaginary worlds similar to our own is considered and it is shown that unification is possible only in ours. This suggests that the low-energy interactions are unique in that they are constructed to make unification possible. (author)

  8. Tackling the Transition to UC: To Implement Unified Communications on Campus, It Often Pays to Take a Phased Approach

    Science.gov (United States)

    Ramaswami, Rama

    2011-01-01

    In this article, the author talks about the challenges faced by two schools that lie, coincidentally, just 110 miles apart in the vast spaces of North Dakota. Both schools, members of the North Dakota University System, decided to forge ahead with a unified communications (UC) implementation. And while their final solutions differ, how the two…

  9. A unified approach to model uptake kinetics of trace elements in complex aqueous – solid solution systems

    International Nuclear Information System (INIS)

    Thien, Bruno M.J.; Kulik, Dmitrii A.; Curti, Enzo

    2014-01-01

    Highlights: • There are several models able to describe trace element partitioning in growing minerals. • To describe complex systems, those models must be embedded in a geochemical code. • We merged two models into a unified one suitable for implementation in a geochemical code. • This unified model was tested against coprecipitation experimental data. • We explored how our model reacts to solution depletion effects. - Abstract: Thermodynamics alone is usually not sufficient to predict growth-rate dependencies of trace element partitioning into host mineral solid solutions. In this contribution, two uptake kinetic models were analyzed that are promising in terms of mechanistic understanding and potential for implementation in geochemical modelling codes. The growth Surface Entrapment Model (Watson, 2004) and the Surface Reaction Kinetic Model (DePaolo, 2011) were shown to be complementary, and under certain assumptions merged into a single analytical expression. This Unified Uptake Kinetics Model was implemented in GEMS3K and GEM-Selektor codes ( (http://gems.web.psi.ch)), a Gibbs energy minimization package for geochemical modelling. This implementation extends the applicability of the unified uptake kinetics model to accounting for non-trivial factors influencing the trace element partitioning into solid solutions, such as the changes in aqueous solution composition and speciation, or the depletion effects in closed geochemical systems

  10. Greater confinement disposal of high activity and special case wastes at the Nevada Test Site: A unified migration assessment approach

    International Nuclear Information System (INIS)

    Davis, P.A.; Olague, N.E.; Johnson, V.L.; Dickman, P.T.; O'Neill, L.J.

    1993-01-01

    The Department of Energy's Nevada Field Office has disposed of a small quantity of high activity and special case wastes using Greater Confinement Disposal facilities in Area 5 of the Nevada Test Site. Because some of these wastes are transuranic radioactive wastes, the Environmental Protection Agency standards for their disposal under 40 CFR Part 191 which requires a compliance assessment. In conducting the 40 CFR Part 191 compliance assessment, review of the Greater Confinement Disposal inventory revealed potentially land disposal restricted hazardous wastes. The regulatory options for disposing of land disposal restricted wastes consist of (1) treatment and monitoring, or (2) developing a no-migration petition. Given that the waste is already buried without treatment, a no-migration petition becomes the primary option. Based on a desire to minimize costs associated with site characterization and performance assessment, a single approach has been developed for assessing compliance with 40 CFR Part 191, DOE Order 5820.2A (which regulates low-level radioactive wastes contained in Greater Confinement Disposal facilities) and developing a no-migration petition. The approach consists of common points of compliance, common time frame for analysis, and common treatment of uncertainty. The procedure calls for conservative bias of modeling assumptions, including model input parameter distributions and adverse processes and events that can occur over the regulatory time frame, coupled with a quantitative treatment of data and parameter uncertainty. This approach provides a basis for a defensible regulatory decision. In addition, the process is iterative between modeling and site characterization activities, where the need for site characterization activities is based on a quantitative definition of the most important and uncertain parameters or assumptions

  11. Exploring the bases for a mixed reality stroke rehabilitation system, Part I: A unified approach for representing action, quantitative evaluation, and interactive feedback

    Science.gov (United States)

    2011-01-01

    Background Although principles based in motor learning, rehabilitation, and human-computer interfaces can guide the design of effective interactive systems for rehabilitation, a unified approach that connects these key principles into an integrated design, and can form a methodology that can be generalized to interactive stroke rehabilitation, is presently unavailable. Results This paper integrates phenomenological approaches to interaction and embodied knowledge with rehabilitation practices and theories to achieve the basis for a methodology that can support effective adaptive, interactive rehabilitation. Our resulting methodology provides guidelines for the development of an action representation, quantification of action, and the design of interactive feedback. As Part I of a two-part series, this paper presents key principles of the unified approach. Part II then describes the application of this approach within the implementation of the Adaptive Mixed Reality Rehabilitation (AMRR) system for stroke rehabilitation. Conclusions The accompanying principles for composing novel mixed reality environments for stroke rehabilitation can advance the design and implementation of effective mixed reality systems for the clinical setting, and ultimately be adapted for home-based application. They furthermore can be applied to other rehabilitation needs beyond stroke. PMID:21875441

  12. Treatment Approaches in Down's Syndrome: A Review.

    Science.gov (United States)

    Foreman, Philip J.; Ward, James

    1986-01-01

    The paper reviews research into treatment approaches in Down's Syndrome. Pharmacological treatments reviewed include thyroid therapy, 5-hydroxytryptophan, vitamin therapy, and cell therapy. Other treatments considered are movement patterning, early intervention, and facial surgery. Early educational intervention is seen as the most effective…

  13. Geodesic curve-of-sight formulae for the cosmic microwave background: a unified treatment of redshift, time delay, and lensing

    International Nuclear Information System (INIS)

    Saito, Ryo; Naruko, Atsushi; Hiramatsu, Takashi; Sasaki, Misao

    2014-01-01

    In this paper, we introduce a new approach to a treatment of the gravitational effects (redshift, time delay and lensing) on the observed cosmic microwave background (CMB) anisotropies based on the Boltzmann equation. From the Liouville's theorem in curved spacetime, the intensity of photons is conserved along a photon geodesic when non-gravitational scatterings are absent. Motivated by this fact, we derive a second-order line-of-sight formula by integrating the Boltzmann equation along a perturbed geodesic (curve) instead of a background geodesic (line). In this approach, the separation of the gravitational and intrinsic effects are manifest. This approach can be considered as a generalization of the remapping approach of CMB lensing, where all the gravitational effects can be treated on the same footing

  14. Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop

    Directory of Open Access Journals (Sweden)

    Kerns William P

    2011-02-01

    Full Text Available Abstract Background Envenomation by crotaline snakes (rattlesnake, cottonmouth, copperhead is a complex, potentially lethal condition affecting thousands of people in the United States each year. Treatment of crotaline envenomation is not standardized, and significant variation in practice exists. Methods A geographically diverse panel of experts was convened for the purpose of deriving an evidence-informed unified treatment algorithm. Research staff analyzed the extant medical literature and performed targeted analyses of existing databases to inform specific clinical decisions. A trained external facilitator used modified Delphi and structured consensus methodology to achieve consensus on the final treatment algorithm. Results A unified treatment algorithm was produced and endorsed by all nine expert panel members. This algorithm provides guidance about clinical and laboratory observations, indications for and dosing of antivenom, adjunctive therapies, post-stabilization care, and management of complications from envenomation and therapy. Conclusions Clinical manifestations and ideal treatment of crotaline snakebite differ greatly, and can result in severe complications. Using a modified Delphi method, we provide evidence-informed treatment guidelines in an attempt to reduce variation in care and possibly improve clinical outcomes.

  15. Detection and typing of human papillomaviruses in mucosal and cutaneous biopsies from immunosuppressed and immunocompetent patients and patients with epidermodysplasia verruciformis: a unified diagnostic approach.

    OpenAIRE

    Surentheran, T; Harwood, C A; Spink, P J; Sinclair, A L; Leigh, I M; Proby, C M; McGregor, J M; Breuer, J

    1998-01-01

    AIM: To develop a unified diagnostic approach for the detection of human papillomavirus (HPV) DNA in skin and mucosal biopsies from both immunocompetent and immunosuppressed individuals using a degenerate polymerase chain reaction (PCR) method. METHODS: The sensitivity and specificity of three published degenerate primer sets (HVP2/B5 and F14/B15; MY09/MY11; CP62/69 outer and CP65/68 nested primer pairs) were evaluated in PCR reactions with serial dilutions of 12 representative cloned HPV typ...

  16. Unified approach to numerical transfer matrix methods for disordered systems: applications to mixed crystals and to elasticity percolation

    International Nuclear Information System (INIS)

    Lemieux, M.A.; Breton, P.; Tremblay, A.M.S.

    1985-01-01

    It is shown that the Negative Eigenvalue Theorem and transfer matrix methods may be considered within a unified framework and generalized to compute projected densities of states or, more generally, any linear combination of matrix elements of the inverse of large symmetric random matrices. As examples of applications, extensive simulations for one- and two-mode behaviour in the Raman spectrum of one-dimensional mixed crystals and a finite-size analysis of critical exponents for the central force percolation universality class are presented

  17. Unifying Physics

    Science.gov (United States)

    Goradia, Shantilal

    2013-04-01

    Century old GR fails to unify quantum physics, nuclear force or distinguish between the mass of living bodies from inert mass. Probabilistic gravity [1] explains strong coupling (nuclear force). The natural log of the age of the universe, 10E60 in Planck times, equaling 137 (1/Alpha) extends physics to deeper science, if we stand on the shoulders of giants like Feynman and Gamow. Implications of [1] are that it is not the earth, but M and S numbers of the particles of the earth are remotely interacting with corresponding numbers of the particles of the moon and the sun respectively, neglecting other heavenly bodies in this short draft. This new physics is likely to enable creative scientific minds to throw light on a theoretical basis for an otherwise arbitrary cosmological constant, uniformity of microwave background, further vindication of Boltzmann, quantum informatics, Einstein’s later publicized views and more, eliminating the need to spend money for implicitly nonexistent quantum gravity and graviton.[4pt] [1] Journal of Physical Science and Applications 2 (7) (2012) 265-268.

  18. Complex Regional Pain Syndrome and Treatment Approaches

    Directory of Open Access Journals (Sweden)

    Neslihan Gokcen

    2013-08-01

    Full Text Available Complex Regional Pain Syndrome is a symptom complex including severe pain which is disproportioned by the initiating event. Formerly, it was known as reflex sympathetic dystropy, Sudeck’s atrophy and algoneurodystrophy. There are two types of complex regional pain syndrome (CPRS. CRPS type 1 (Reflex sympathetic dystropy occurs after a minor trauma of the extremities, CRPS type 2 (Causalgia occurs following peripheral nevre injury. Diagnosis is made according to the history, symptoms and physical findings of the patients. Patient education, physical therapy and medical treatment are the most common treatment approaches of complex regional pain syndrome. The aim of this review is to revise the treatment options ofcomplex regional pain syndrome, as well as to overview the new treatment approaches and options for the refractory complex regional pain syndrome cases. [Archives Medical Review Journal 2013; 22(4.000: 514-531

  19. Unified Bohm criterion

    Energy Technology Data Exchange (ETDEWEB)

    Kos, L. [LECAD Laboratory, Faculty of Mechanical Engineering, University of Ljubljana, SI-1000 Ljubljana (Slovenia); Tskhakaya, D. D.; Jelić, N. [Institute for Theoretical Physics, Fusion@ÖAW, University of Innsbruck, A-6020 Innsbruck (Austria)

    2015-09-15

    Recent decades have seen research into the conditions necessary for the formation of the monotonic potential shape in the sheath, appearing at the plasma boundaries like walls, in fluid, and kinetic approximations separately. Although either of these approaches yields a formulation commonly known as the much-acclaimed Bohm criterion (BC), the respective results involve essentially different physical quantities that describe the ion gas behavior. In the fluid approach, such a quantity is clearly identified as the ion directional velocity. In the kinetic approach, the ion behavior is formulated via a quantity (the squared inverse velocity averaged by the ion distribution function) without any clear physical significance, which is, moreover, impractical. In the present paper, we try to explain this difference by deriving a condition called here the Unified Bohm Criterion, which combines an advanced fluid model with an upgraded explicit kinetic formula in a new form of the BC. By introducing a generalized polytropic coefficient function, the unified BC can be interpreted in a form that holds, irrespective of whether the ions are described kinetically or in the fluid approximation.

  20. Clinical approaches to treatment of Internet addiction.

    Science.gov (United States)

    Przepiorka, Aneta Małgorzata; Blachnio, Agata; Miziak, Barbara; Czuczwar, Stanisław Jerzy

    2014-04-01

    Internet appearance was one of the main breakthroughs for the mankind in the latest decades. It revolutionized our lives in many aspects and brought about many undeniably positive changes. However, at the same time caused negative consequences. It has led to the emergence of the Internet addiction (IA). The paper is concerned with the issue of treatment of IA. The paper reviews the current findings on the approaches to IA treatment and evaluates their effectiveness. The main focus of the article concentrates on cognitive and pharmacologic treatment. The individual approach to IA treatment is advisable. Among drugs for the management of IA, antidepressants, antipsychotics, opioid receptor antagonists, glutamate receptor antagonists, and psychostimulants may be recommended. Some antiepileptics, and especially valproate, are considered as potential drugs for the treatment of IA. Effective therapy may require an individual approach and best results are expected when psychological and pharmacological treatments are combined. Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  1. Treatment and Counseling Approaches for Eating Disorders.

    Science.gov (United States)

    Hamilton, Kristin L.

    Maladaptive eating behaviors are a growing phenomenon which has captured the interest of not only health and psychology professionals, but also the general public. This paper examines the various types of treatment and counseling approaches for treating anorexia nervosa and bulimia nervosa. Definitions for both disorders are provided, followed by…

  2. Different approaches to acute organophosphorus poison treatment.

    Science.gov (United States)

    Nurulain, Syed Muhammad

    2012-07-01

    Organophosphorus compounds (OPCs) have a wide variety of applications and are a serious threat for self-poisoning, unintentional misuse, terrorist attack, occupational hazard and warfare attack. The present standard treatment has been reported to be unsatisfactory. Many novel approaches are being used and tested for acute organophosphorus (OP) poison treatment. The bioscavenger concept captured high attention among the scientific community during the last few decades. Other approaches like alkalinisation of blood plasma/serum and use of weak inhibitors against strong inhibitors, though it showed promising results, did not get such wide attention. The introduction of a novel broad-spectrum oxime has also been in focus. In this mini-review, an update of the overview of four different approaches has been discussed. The standard therapy that is atropine+oxime+benzodiazepine along with supportive measures will continue to be the best option with only the replacement of a single oxime to improve its broad-spectrum efficacy.

  3. Multidisciplinary treatment approach in Treacher Collins syndrome.

    Science.gov (United States)

    Hylton, Joseph B; Leon-Salazar, Vladimir; Anderson, Gary C; De Felippe, Nanci L O

    2012-01-01

    Treacher Collins syndrome (TCS) is a common genetic disorder with high penetrance and phenotypic variability. First and second branchial arches are affected in TCS, resulting in craniofacial and intraoral anomalies such as: severe convex facial profile; mid-face hypoplasia; microtia; eyelid colobomas; mandibular retrognathism; cleft palate; dental hypoplasia; heterotopic teeth; maxillary transverse hypoplasia; anterior open bite; and Angle Class II molar relationship. A high incidence of caries is also a typical finding in TCS patients. Nonetheless, even simple dental restorative procedures can be challenging in this patient population due to other associated medical conditions, such as: congenital heart defects; decreased oropharyngeal airways; hearing loss; and anxiety toward treatment. These patients often require a multidisciplinary treatment approach, including: audiology; speech and language pathology; otorhinolaryngology; general dentistry; orthodontics; oral and maxillofacial surgery; and plastic and reconstructive surgeries to improve facial appearance. This paper's purpose was to present a current understanding of Treacher Collins syndrome etiology, phenotype, and current treatment approaches.

  4. Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations

    Science.gov (United States)

    Schulz-Hildebrandt, H.; Münter, Michael; Ahrens, M.; Spahr, H.; Hillmann, D.; König, P.; Hüttmann, G.

    2018-03-01

    Optical coherence tomography (OCT) images scattering tissues with 5 to 15 μm resolution. This is usually not sufficient for a distinction of cellular and subcellular structures. Increasing axial and lateral resolution and compensation of artifacts caused by dispersion and aberrations is required to achieve cellular and subcellular resolution. This includes defocus which limit the usable depth of field at high lateral resolution. OCT gives access the phase of the scattered light and hence correction of dispersion and aberrations is possible by numerical algorithms. Here we present a unified dispersion/aberration correction which is based on a polynomial parameterization of the phase error and an optimization of the image quality using Shannon's entropy. For validation, a supercontinuum light sources and a costume-made spectrometer with 400 nm bandwidth were combined with a high NA microscope objective in a setup for tissue and small animal imaging. Using this setup and computation corrections, volumetric imaging at 1.5 μm resolution is possible. Cellular and near cellular resolution is demonstrated in porcine cornea and the drosophila larva, when computational correction of dispersion and aberrations is used. Due to the excellent correction of the used microscope objective, defocus was the main contribution to the aberrations. In addition, higher aberrations caused by the sample itself were successfully corrected. Dispersion and aberrations are closely related artifacts in microscopic OCT imaging. Hence they can be corrected in the same way by optimization of the image quality. This way microscopic resolution is easily achieved in OCT imaging of static biological tissues.

  5. Unified Internet Messaging

    OpenAIRE

    Healy, Paul; Barber, Declan

    2015-01-01

    As telephony services, mobile services and internet services continue to converge, the prospect of providing Unified Messaging and even Unified Communications becomes increasingly achievable. This paper discusses the growing importance of IP-based networks to Unified Messaging developments and examines some of the key services and protocols that are likely to make Unified Messaging more widely available. In this initial paper, we limit ourselves initially to the unification of text-based mess...

  6. [Approaches in the treatment of pathologic gambling].

    Science.gov (United States)

    Nespor, K

    1994-06-01

    In the treatment of pathological gambling the diagnosis, treatment of the accessory psychopathology and the somatic condition are important. Motivation training, behavioural and reality-oriented therapy, modification of the lifestyle relaxation techniques and yoga proved useful. There is also experience with dynamically oriented treatment techniques self-esteem reinforcement, training of social skills, strategies which promote impulse control, artetherapy, group therapy, provision of relevant information etc. Family therapy is important both for a pathological gambler and his/her relatives. Very important is contact with the family of the pathological gambler for his own treatment and with regard to the needs of his/her relatives. A therapeutic approach common abroad is participation in a self-help group, Gamblers Anonymous.

  7. Adult orthodontics: multi- or interdisciplinary treatment approach

    DEFF Research Database (Denmark)

    Melsen, Birte

    2007-01-01

    An increasing number of adult patients seen in the orthodontic offices are presenting with an ongoing degeneration caused either by loss of one or more teeth and/or progressing periodontal disease. The treatment of these patients can rarely stand alone and both diagnosis and treatment planning...... experiments carried out on monkeys and dogs have repeatedly demonstrated that it is possible to regain lost attachment even in the case of horizontal bone loss through a carefully conducted combined periodontal- and orthodontic treatment and long-term follow-up have confirmed that the results can...... of the conservative approach practiced in many places within periodontology, it should be appreciated that any orthodontic tooth movement involving intrusive components should not be performed in the presence of pathological pockets. New regenerative periodontal treatment procedures have improved the prognosis...

  8. ACHP | Unified Federal Review

    Science.gov (United States)

    Search skip specific nav links Home arrow Unified Federal Review Three logos: 1) Executive Office of the Homeland Security. Unified Federal Environmental and Historic Preservation Review Process Please visit the new location for the Unified Federal Review located here: http://www.fema.gov/environmental-historic

  9. A rational quantitative approach to determine the best dosing regimen for a target therapeutic effect: a unified formalism for antibiotic evaluation.

    Science.gov (United States)

    Li, Jun; Nekka, Fahima

    2013-02-21

    The determination of an optimal dosing regimen is a critical step to enhance the drug efficacy and avoid toxicity. Rational dosing recommendations based on mathematical considerations are increasingly being adopted in the process of drug development and use. In this paper, we propose a quantitative approach to evaluate the efficacy of antibiotic agents. By integrating both pharmacokinetic (PK) and pharmacodynamic (PD) information, this approach gives rise to a unified formalism able to measure the cause-effect of dosing regimens. This new pharmaco-metric allows to cover a whole range of antibiotics, including the two well known concentration and time dependent classes, through the introduction of the Hill-dependency concept. As a direct fallout, our formalism opens a new path toward the bioequivalence evaluation in terms of PK and PD, which associates the in vivo drug concentration and the in vitro drug effect. Using this new approach, we succeeded to reveal unexpected, but relevant behaviors of drug performance when different drug regimens and drug classes are considered. Of particular notice, we found that the doses required to reach the same therapeutic effect, when scheduled differently, exhibit completely different tendencies for concentration and time dependent drugs. Moreover, we theoretically confirmed the previous experimental results of the superiority of the once daily regimen of aminoglycosides. The proposed methodology is appealing for its computational features and can easily be applicable to design fair clinical protocols or rationalize prescription decisions. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Budget impact analysis of the percutaneous septal occluder for treatment of ostium secundum atrial septal defects in the Brazilian Unified National Health System.

    Science.gov (United States)

    Senna, Kátia Marie Simões e; Sarti, Flavia Mori; Costa, Márcia Gisele Santos da; Nita, Marcelo Eidi; Santos, Marisa da Silva; Tura, Bernardo Rangel; Correia, Marcelo Goulart

    2015-08-01

    The aim of this study was to perform a budget impact analysis on the adoption of percutaneous occlusion of ostium secundum atrial septal defects in the Brazilian Unified National Health System. Costs were collected using micro-costing technique from medical records for each treatment technique (conventional surgery versus percutaneous septal occluder) at a public federal hospital specialized in high-complexity cardiology. The analysis showed that expenditures associated with percutaneous occlusion were lower than with conventional surgery, and sensitivity analysis confirmed the cost reduction in several scenarios, showing a significant budget impact with a 30% adoption rate for the percutaneous occluder (savings of approximately 1.5 million dollars per year). The study indicates that the adoption of the percutaneous septal occluder would mean cost savings of approximately 3.5 million dollars for the Brazilian public health system.

  11. Unified treatment of microscopic boundary conditions and efficient algorithms for estimating tangent operators of the homogenized behavior in the computational homogenization method

    Science.gov (United States)

    Nguyen, Van-Dung; Wu, Ling; Noels, Ludovic

    2017-03-01

    This work provides a unified treatment of arbitrary kinds of microscopic boundary conditions usually considered in the multi-scale computational homogenization method for nonlinear multi-physics problems. An efficient procedure is developed to enforce the multi-point linear constraints arising from the microscopic boundary condition either by the direct constraint elimination or by the Lagrange multiplier elimination methods. The macroscopic tangent operators are computed in an efficient way from a multiple right hand sides linear system whose left hand side matrix is the stiffness matrix of the microscopic linearized system at the converged solution. The number of vectors at the right hand side is equal to the number of the macroscopic kinematic variables used to formulate the microscopic boundary condition. As the resolution of the microscopic linearized system often follows a direct factorization procedure, the computation of the macroscopic tangent operators is then performed using this factorized matrix at a reduced computational time.

  12. Recent considerations in regenerative endodontic treatment approaches

    Directory of Open Access Journals (Sweden)

    Hacer Aksel

    2014-09-01

    Conclusion: Although the regenerative treatment approaches have good clinical outcomes in the majority of case reports, the outcomes are unpredictable. Since the current clinical protocols for regenerative endodontics do not fully fulfill the triad of tissue engineering ((growth factors, scaffold and stem cells, further translational studies are required to achieve more pulp- and dentin-like tissue in the root canal system to achieve pulp regeneration.

  13. A Unified Spatiotemporal Modeling Approach for Predicting Concentrations of Multiple Air Pollutants in the Multi-Ethnic Study of Atherosclerosis and Air Pollution

    Science.gov (United States)

    Olives, Casey; Kim, Sun-Young; Sheppard, Lianne; Sampson, Paul D.; Szpiro, Adam A.; Oron, Assaf P.; Lindström, Johan; Vedal, Sverre; Kaufman, Joel D.

    2014-01-01

    Background: Cohort studies of the relationship between air pollution exposure and chronic health effects require predictions of exposure over long periods of time. Objectives: We developed a unified modeling approach for predicting fine particulate matter, nitrogen dioxide, oxides of nitrogen, and black carbon (as measured by light absorption coefficient) in six U.S. metropolitan regions from 1999 through early 2012 as part of the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air). Methods: We obtained monitoring data from regulatory networks and supplemented those data with study-specific measurements collected from MESA Air community locations and participants’ homes. In each region, we applied a spatiotemporal model that included a long-term spatial mean, time trends with spatially varying coefficients, and a spatiotemporal residual. The mean structure was derived from a large set of geographic covariates that was reduced using partial least-squares regression. We estimated time trends from observed time series and used spatial smoothing methods to borrow strength between observations. Results: Prediction accuracy was high for most models, with cross-validation R2 (R2CV) > 0.80 at regulatory and fixed sites for most regions and pollutants. At home sites, overall R2CV ranged from 0.45 to 0.92, and temporally adjusted R2CV ranged from 0.23 to 0.92. Conclusions: This novel spatiotemporal modeling approach provides accurate fine-scale predictions in multiple regions for four pollutants. We have generated participant-specific predictions for MESA Air to investigate health effects of long-term air pollution exposures. These successes highlight modeling advances that can be adopted more widely in modern cohort studies. Citation: Keller JP, Olives C, Kim SY, Sheppard L, Sampson PD, Szpiro AA, Oron AP, Lindström J, Vedal S, Kaufman JD. 2015. A unified spatiotemporal modeling approach for predicting concentrations of multiple air pollutants in the Multi

  14. Intensity modulated radiotherapy (IMRT) for patients of the Brazilian unified health system (SUS): an analysis of 508 treatments two years after the technique implementation

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Harley Francisco de; Trevisan, Felipe Amstalden; Bighetti, Viviane Marques; Guimaraes, Flavio da Silva; Amaral, Leonardo Lira; Barbi, Gustavo Lazaro; Borges, Leandro Federiche; Peria, Fernanda Maris, E-mail: harley@fmrp.usp.br [Universidade de Sao Paulo (FMRP/USP), Ribeirao Preto, SP (Brazil). Faculdade de Medicina

    2014-11-15

    Objective: the offering of high-technology radiotherapy to the population assisted by the Brazilian unified health system (SUS) is limited since it is not included in the system’s list of procedures and, many times, because of the insufficient installed capacity and lack of specialized human resources. Thus the access to intensity-modulated radiotherapy (IMRT) is restricted to few centers in Brazil. The present study is aimed at presenting the characteristics of the first 508 cases treated with IMRT during the first years after the technique implementation in a university hospital. Materials and methods: the first consecutive 508 cases of IMRT treatment completed in the period from May/2011 to September/2013 were reviewed. Static multi leaf was the technique employed. Results: amongst 4,233 treated patients, 12.5% were submitted to IMRT. Main indications for the treatment included cancers located in the skull, head and neck and prostate. Intensity modulated radiotherapy was utilized in about 30% of cranial and 50% of prostate treatments. Treatment toxicity was observed in 4% of the patients. Conclusion: because of restricted access to radiotherapy in addition to lack of coverage for the procedure, IMRT indications for SUS patients should be based on institutional clinical protocols, with special attention to the reduction of toxicity. (author)

  15. Narcolepsy: current treatment options and future approaches

    Science.gov (United States)

    Billiard, Michel

    2008-01-01

    The management of narcolepsy is presently at a turning point. Three main avenues are considered in this review: 1) Two tendencies characterize the conventional treatment of narcolepsy. Modafinil has replaced methylphenidate and amphetamine as the first-line treatment of excessive daytime sleepiness (EDS) and sleep attacks, based on randomized, double blind, placebo-controlled clinical trials of modafinil, but on no direct comparison of modafinil versus traditional stimulants. For cataplexy, sleep paralysis, and hypnagogic hallucinations, new antidepressants tend to replace tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) in spite of a lack of randomized, double blind, placebo-controlled clinical trials of these compounds; 2) The conventional treatment of narcolepsy is now challenged by sodium oxybate, the sodium salt of gammahydroxybutyrate, based on a series of randomized, double-blind, placebo-controlled clinical trials and a long-term open label study. This treatment has a fairly good efficacy and is active on all symptoms of narcolepsy. Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3) A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy. PMID:18830438

  16. Narcolepsy: current treatment options and future approaches

    Directory of Open Access Journals (Sweden)

    Michel Billiard

    2008-06-01

    Full Text Available Michel BilliardDepartment of Neurology, Gui de Chauliac Hospital, Montpellier, FranceAbstract: The management of narcolepsy is presently at a turning point. Three main avenues are considered in this review: 1 Two tendencies characterize the conventional treatment of narcolepsy. Modafinil has replaced methylphenidate and amphetamine as the first-line treatment of excessive daytime sleepiness (EDS and sleep attacks, based on randomized, double blind, placebo-controlled clinical trials of modafinil, but on no direct comparison of modafinil versus traditional stimulants. For cataplexy, sleep paralysis, and hypnagogic hallucinations, new antidepressants tend to replace tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs in spite of a lack of randomized, double blind, placebo-controlled clinical trials of these compounds; 2 The conventional treatment of narcolepsy is now challenged by sodium oxybate, the sodium salt of gammahydroxybutyrate, based on a series of randomized, double-blind, placebo-controlled clinical trials and a long-term open label study. This treatment has a fairly good efficacy and is active on all symptoms of narcolepsy. Careful titration up to an adequate level is essential both to obtain positive results and avoid adverse effects; 3 A series of new treatments are currently being tested, either in animal models or in humans, They include novel stimulant and anticataplectic drugs, endocrine therapy, and, more attractively, totally new approaches based on the present state of knowledge of the pathophysiology of narcolepsy with cataplexy, hypocretine-based therapies, and immunotherapy.Keywords: narcolepsy, treatment, conventional drugs, modafinil, sodium oxybate, future treatments

  17. A UNIFIED APPROACH FOR DETECTION AND PREVENTION OF DDOS ATTACKS USING ENHANCED SUPPORT VECTOR MACHINES AND FILTERING MECHANISMS

    Directory of Open Access Journals (Sweden)

    T. Subbulakshmi

    2014-10-01

    Full Text Available Distributed Denial of Service (DDoS attacks were considered to be a tremendous threat to the current information security infrastructure. During DDoS attack, multiple malicious hosts that are recruited by the attackers launch a coordinated attack against one host or a network victim, which cause denial of service to legitimate users. The existing techniques suffer from more number of false alarms and more human intervention for attack detection. The objective of this paper is to monitor the network online which automatically initiates detection mechanism if there is any suspicious activity and also defense the hosts from being arrived at the network. Both spoofed and non spoofed IP’s are detected in this approach. Non spoofed IP’s are detected using Enhanced Support Vector Machines (ESVM and spoofed IP’s are detected using Hop Count Filtering (HCF mechanism. The detected IP’s are maintained separately to initiate the defense process. The attack strength is calculated using Lanchester Law which initiates the defense mechanism. Based on the calculated attack strength any of the defense schemes such as Rate based limiting or History based IP filtering is automatically initiated to drop the packets from the suspected IP. The integrated online monitoring approach for detection and defense of DDoS attacks is deployed in an experimental testbed. The online approach is found to be obvious in the field of integrated DDoS detection and defense.

  18. A Unified Approach to Adaptive Neural Control for Nonlinear Discrete-Time Systems With Nonlinear Dead-Zone Input.

    Science.gov (United States)

    Liu, Yan-Jun; Gao, Ying; Tong, Shaocheng; Chen, C L Philip

    2016-01-01

    In this paper, an effective adaptive control approach is constructed to stabilize a class of nonlinear discrete-time systems, which contain unknown functions, unknown dead-zone input, and unknown control direction. Different from linear dead zone, the dead zone, in this paper, is a kind of nonlinear dead zone. To overcome the noncausal problem, which leads to the control scheme infeasible, the systems can be transformed into a m -step-ahead predictor. Due to nonlinear dead-zone appearance, the transformed predictor still contains the nonaffine function. In addition, it is assumed that the gain function of dead-zone input and the control direction are unknown. These conditions bring about the difficulties and the complicacy in the controller design. Thus, the implicit function theorem is applied to deal with nonaffine dead-zone appearance, the problem caused by the unknown control direction can be resolved through applying the discrete Nussbaum gain, and the neural networks are used to approximate the unknown function. Based on the Lyapunov theory, all the signals of the resulting closed-loop system are proved to be semiglobal uniformly ultimately bounded. Moreover, the tracking error is proved to be regulated to a small neighborhood around zero. The feasibility of the proposed approach is demonstrated by a simulation example.

  19. A unified factor-analytic approach to the detection of item and test bias: Illustration with the effect of providing calculators to students with dyscalculia

    Directory of Open Access Journals (Sweden)

    Lee, M. K.

    2016-01-01

    Full Text Available An absence of measurement bias against distinct groups is a prerequisite for the use of a given psychological instrument in scientific research or high-stakes assessment. Factor analysis is the framework explicitly adopted for the identification of such bias when the instrument consists of a multi-test battery, whereas item response theory is employed when the focus narrows to a single test composed of discrete items. Item response theory can be treated as a mild nonlinearization of the standard factor model, and thus the essential unity of bias detection at the two levels merits greater recognition. Here we illustrate the benefits of a unified approach with a real-data example, which comes from a statewide test of mathematics achievement where examinees diagnosed with dyscalculia were accommodated with calculators. We found that items that can be solved by explicit arithmetical computation became easier for the accommodated examinees, but the quantitative magnitude of this differential item functioning (measurement bias was small.

  20. Endoscopic approaches to treatment of achalasia

    Science.gov (United States)

    Friedel, David; Modayil, Rani; Iqbal, Shahzad; Grendell, James H.

    2013-01-01

    Endoscopic therapy for achalasia is directed at disrupting or weakening the lower esophageal sphincter (LES). The two most commonly utilized endoscopic interventions are large balloon pneumatic dilation (PD) and botulinum toxin injection (BTI). These interventions have been extensively scrutinized and compared with each other as well as with surgical disruption (myotomy) of the LES. PD is generally more effective in improving dysphagia in achalasia than BTI, with the latter reserved for infirm older people, and PD may approach treatment results attained with myotomy. However, PD may need to be repeated. Small balloon dilation and endoscopic stent placement for achalasia have only been used in select centers. Per oral endoscopic myotomy is a newer endoscopic modality that will likely change the treatment paradigm for achalasia. It arose from the field of natural orifice transluminal endoscopic surgery and represents a scarless endoscopic approach to Heller myotomy. This is a technique that requires extensive training and preparation and thus there should be rigorous accreditation and monitoring of outcomes to ensure safety and efficacy. PMID:23503707

  1. A new approach for water treatment

    CERN Document Server

    Principe, R

    1999-01-01

    A quantity of up to 4000 m3/h of water is used at CERN for cooling purposes: experiments, magnets and radio frequency cavities are refrigerated by closed circuits filled with deionized water; other utilities, such as air-conditioning, use chilled/hot water, also in closed circuits. All these methods all employ a cold source, the primary supply of water, coming from the cooling towers. About 500 kCHF are spent every year on water treatment in order to keep the water within these networks in operational conditions. In the line of further rationalization of resources, the next generation of contracts with the water treatment industry will aim for improved performance and better monitoring of quality related parameters in this context. The author will provide a concise report based upon an examination of the state of the installations and of the philosophy followed up until now for water treatment. Furthermore, he/she will propose a new approach from both a technical and contractual point of view, in preparation ...

  2. A Unified Moment-Based Approach for the Evaluation of the Outage Probability with Noise and Interference

    KAUST Repository

    Rached, Nadhir Ben

    2016-12-05

    In this paper, we develop a novel moment-based approach for the evaluation of the outage probability (OP) in a generalized fading environment with interference and noise. Our method is based on the derivation of a power series expansion of the OP of the signal-to-interference-plus-noise ratio (SINR). It does not necessitate stringent requirements, the only major ones being the existence of a power series expansion of the cumulative distribution function of the desired user power and the knowledge of the cross-moments of the interferers’ powers. The newly derived formula is shown to be applicable for most of the well-practical fading models of the desired user under some assumptions on the parameters of the powers’ distributions. A further advantage of our method is that it is applicable irrespective of the nature of the fading models of the interfering powers, the only requirement being the perfect knowledge of their crossmoments. In order to illustrate the wide scope of applicability of our technique, we present a convergence study of the provided formula for the Generalized Gamma and the Rice fading models. Moreover, we show that our analysis has direct bearing on recent multi-channel applications using selection diversity techniques. Finally, we assess by simulations the accuracy of the proposed formula for various fading environments.

  3. A unified approach for designing a photovoltaic solar system for the underground water pumping well-34 at Disi aquifer

    International Nuclear Information System (INIS)

    Ebaid, Munzer S.Y.; Qandil, Hasan; Hammad, Mahmoud

    2013-01-01

    Highlights: • Photovoltaic system for the underground water pumping wells at Disi aquifer was designed. • Solar irradiation values on horizontal and tilted surfaces were identified. • Method of the worst month MWM and peak sun hours PSH method were applied. • Thirty-eight percentage of the total PV panels would not be used beyond the design conditions (December). • Dust accumulation problem were solved by cleaning or as a 5% power loss factor. - Abstract: This paper aims to present a detailed design of a standalone photovoltaic system used to power continuously a submersible water pump from a selected well (Well-34 of a current static water level, SWL = 147.3 m), out of 55 production wells located at the Disi aquifer, where each of these wells should have a continuously-operating water flow rate of 80 l/s (288 m 3 /h) according to the Disi project specifications. Initially, solar irradiation calculations on horizontal and tilted surfaces were carried out to identify the potential of solar energy available in kW h/m 2 /day in the Disi aquifer. Then, a system design approach based on the worst month of the year (December) was carried out to choose and size the components of photovoltaic system that is required to operate the submersible pump over the 25-year operation period. The system sizing implies defining the number and type of solar panels required to capture the available solar energy, the capacity and number of batteries, inverter rating, cable sizing, charge controller numbers and rating to ensure the maximum reliability of the system. Furthermore, beyond the design conditions of the worst month (December), extra energy can be produced by the PV system during the rest of the year time, which can be used for many purposes. Also, the design process considers the problem of dust accumulation on PV surfaces and this can be dealt with by periodic cleaning

  4. Physical treatment planning by several approaches

    International Nuclear Information System (INIS)

    Burger, G.; Morhart, A.; Wittmann, A.

    1985-01-01

    Neutron isodose planning may be performed by commercial treatment planning systems for photons, providing that certain modifications are applied. All geometry-related corrections such as for nonregular surfaces and oblique incidence remain unchanged. The main modifications concern the tissue-air-ratio, containing essentially the attenuation correction function. We have as a first step applied this modified commercial system to a few regular exposure situations in a homogenious water phantom and compared the generated isodose charts with those derived by direct Monte Carlo calculations of the neutron transport for the corresponding fields. As expected the commercial methods do not incorporate the necessary corrections for the change of scatter conditions in case of oblique incidence or wedged fields. For this reason we developed another approach, based upon the numerical superposition of dose matrices for pencil beams. These matrices were again Monte Carlo calculated. From it build-up functions can be derived by partial radial integration. The isodose charts generated by superposition of pencil beam dose distributions agree much better with directly Monte Carlo calculated ones, than those from the commercial treatment planning system. Based upon these results the method was finally applied to real patients cross sections, as derived from CT or MR-tomography. In the latter case one can even perform a pixelwise attenuation correction, if spin density images are available

  5. [Treatment of generalized anxiety: new pharmacologic approaches].

    Science.gov (United States)

    Boulenger, J P

    1995-01-01

    . However, it will also be important to know if wether or not the efficacy of these new drugs, like that of buspirone, is associated with some effects on depressive symptomatology, develops only progressively over time and is different in previous BZD users compared to GAD patients who did not receive BZD before the new drug. Among these drugs in development for GAD, the most likely to reach the market in a near future are a BZD partial agonist (abecarnil), 5-HT1A agonists like ipsapirone and 5-HT3 antagonists like ondansetron. However, another area of new developments concerning the drug treatment of GAD is the use of antidepressants, which have demonstrated efficacy in this indication even in patients without depressive features or panic attacks symptoms. Considering the chronic nature of GAD, these drugs, like those acting on the 5-HT-system, would be more adapted than BZD for the long-term management of this condition. If confirmed by clinical trials involving antidepressants other than tricyclics, the efficacy of these drugs in GAD may suggest that common neurobiological mechanisms are involved in the pathogenesis of both anxiety and depressive disorders. Despite the potential interest of these new treatments of GAD, recent years have shown that the development of new anxiolytic drugs often appears limited by high-rates of placebo response in numerous clinical trials. This phenomenon may be related--in part--to the increasingly sophisticated designs used in such trials, such as extensive diagnostic workups, repeated evaluations and inclusion criteria selecting the less severe types of anxiety. As emphasized by other authors, much more research needs to be done to establish what effects various ways of conducting a trial have on the trial's results in order to facilitate the emergence of new psychopharmacological approaches in the treatment of GAD.

  6. A Unified Electronic Tool for CPR and Emergency Treatment Escalation Plans Improves Communication and Early Collaborative Decision Making for Acute Hospital Admissions.

    Science.gov (United States)

    Johnson, Mae; Whyte, Martin; Loveridge, Robert; Yorke, Richard; Naleem, Shairana

    2017-01-01

    The National Confidential Enquiry into Patient Outcomes and Death (NCEPOD) report 'Time to Intervene' (2012) stated that in a substantial number of cases, resuscitation is attempted when it was thought a 'do not attempt cardiopulmonary resuscitation' (DNACPR) decision should have been in place. Early decisions about CPR status and advance planning about limits of care now form part of national recommendations by the UK Resuscitation Council (2016). Treatment escalation plans (TEP) document what level of treatment intervention would be appropriate if a patient were to become acutely unwell and were not previously formally in place at King's College Hospital. A unifying paper based form was successfully piloted in the Acute Medical Unit, introducing the TEP and bringing together decision making around both treatment escalation and CPR status. Subsequently an electronic order-set for CPR status and treatment escalation was launched in April 2015 which led to a highly visible CPR and escalation status banner on the main screen at the top of the patient's electronic record. Ultimately due to further iterations in the electronic process by December 2016, all escalation decisions for acutely admitted patients now have high quality supporting, explanatory documentation with 100% having TEPs in place. There is now widespread multidisciplinary engagement in the process of defining limits of care for acutely admitted medical patients within the first 14 hours of admission and a strategy for rolling this process out across all the divisions of the hospital through our Deteriorating Patient Group (DPG). The collaborative design with acute medical, palliative and intensive care teams and the high visibility provided by the electronic process in the Electronic Patient Record (EPR) has enhanced communication with these teams, patients, nursing staff and the multidisciplinary team by ensuring clarity through a universally understood process about escalation and CPR. Clarity and

  7. A unified grand tour of theoretical physics

    CERN Document Server

    Lawrie, Ian D

    2013-01-01

    A Unified Grand Tour of Theoretical Physics invites its readers to a guided exploration of the theoretical ideas that shape our contemporary understanding of the physical world at the fundamental level. Its central themes, comprising space-time geometry and the general relativistic account of gravity, quantum field theory and the gauge theories of fundamental forces, and statistical mechanics and the theory of phase transitions, are developed in explicit mathematical detail, with an emphasis on conceptual understanding. Straightforward treatments of the standard models of particle physics and cosmology are supplemented with introductory accounts of more speculative theories, including supersymmetry and string theory. This third edition of the Tour includes a new chapter on quantum gravity, focusing on the approach known as Loop Quantum Gravity, while new sections provide extended discussions of topics that have become prominent in recent years, such as the Higgs boson, massive neutrinos, cosmological perturba...

  8. Osteopetroses, emphasizing potential approaches to treatment.

    Science.gov (United States)

    Teti, Anna; Econs, Michael J

    2017-09-01

    interfering RNA approach and novel pharmacologic treatments. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Writing Treatment for Aphasia: A Texting Approach

    Science.gov (United States)

    Beeson, Pelagie M.; Higginson, Kristina; Rising, Kindle

    2013-01-01

    Purpose: Treatment studies have documented the therapeutic and functional value of lexical writing treatment for individuals with severe aphasia. The purpose of this study was to determine whether such retraining could be accomplished using the typing feature of a cellular telephone, with the ultimate goal of using text messaging for…

  10. Current treatment approach of bone metastases

    International Nuclear Information System (INIS)

    Gómez Cabrera, Erasmo Pablo

    2016-01-01

    The document deals with the cancer situation in Cuba; the factors that produce and causes destruction of bone metastases. It also describes osteoblastic and osteolytic lesions; and details the different treatments for bone metastases

  11. Vasculitis : Clinical approach, pathophysiology and treatment

    NARCIS (Netherlands)

    Kallenberg, GGM

    2000-01-01

    Systemic vasculitides constitute a heterogeneous group of diseases characterized by inflammation of blood vessels. Classification of the disease is mandatory for the assessment of prognosis and the institution of treatment. Secondary forms of vasculitis should be distinguished from primary

  12. [Clinical laboratory approaches to parodontitis treatment optimization].

    Science.gov (United States)

    Soboleva, L A; Shul'diakov, A A; Oseeva, A O; Aleksandrova, E A

    2010-01-01

    In order to determine cycloferon liniment clinical-pathogenetic efficacy in comprehensive parodontitis therapy examination and treatment of 80 patients was done. It was determined that the cycloferon liniment use in comprehensive treatment of patients with parodontitis let to reduce infectious load in parodontal pockets and local inflammation intensity, to normalize the secretory immunoglobulin level and immune status indices that provided speed up of healing process and reduction relapse frequency.

  13. A critical review of treatment approaches for gambling disorders.

    Science.gov (United States)

    Stea, Jonathan N; Hodgins, David C

    2011-06-01

    This review presents the theoretical model, evidence base, and theoretical and methodological issues for seven treatment approaches to gambling disorders: 1) psychoanalytic and psychodynamic treatments, 2) Gamblers Anonymous, 3) behavioural treatments, 4) cognitive and cognitive-behavioural therapies, 5) brief, motivational, and self-directed interventions, 6) pharmacotherapies, and 7) family therapy approaches. Throughout the review, broader clinical and research issues are also discussed, including barriers to treatment-seeking, controlled gambling versus abstinence as a treatment goal, comorbidity, and the evaluation of treatment efficacy and effectiveness.

  14. Nanotechnology-Based Approach in Tuberculosis Treatment

    Directory of Open Access Journals (Sweden)

    Mohammad Nasiruddin

    2017-01-01

    Full Text Available Tuberculosis, commonly known as TB, is the second most fatal infectious disease after AIDS, caused by bacterium called Mycobacterium tuberculosis. Prolonged treatment, high pill burden, low compliance, and stiff administration schedules are factors that are responsible for emergence of MDR and XDR cases of tuberculosis. Till date, only BCG vaccine is available which is ineffective against adult pulmonary TB, which is the most common form of disease. Various unique antibodies have been developed to overcome drug resistance, reduce the treatment regimen, and elevate the compliance to treatment. Therefore, we need an effective and robust system to subdue technological drawbacks and improve the effectiveness of therapeutic drugs which still remains a major challenge for pharmaceutical technology. Nanoparticle-based ideology has shown convincing treatment and promising outcomes for chronic infectious diseases. Different types of nanocarriers have been evaluated as promising drug delivery systems for various administration routes. Controlled and sustained release of drugs is one of the advantages of nanoparticle-based antituberculosis drugs over free drug. It also reduces the dosage frequency and resolves the difficulty of low poor compliance. This paper reviews various nanotechnology-based therapies which can be used for the treatment of TB.

  15. Grand unified theories

    International Nuclear Information System (INIS)

    Rosner, J.L.

    1987-01-01

    This paper reports on a pedagogical introduction that attempts to unify the strong and electroweak interactions. Unifying groups discussed include SU(5), SO(10), and E 6 . Particular attention is paid to the questions of whether the low-energy gauge group (that accessible at accelerator experiments in the foreseeable future) extends beyond SU(3) x SU(2) L x U(1). Low-energy studies of neutral-current effects, direct production of gauge bosons, and new fermions all can shed light on this question. Brief remarks are made concerning the role of monopoles, cosmic strings, baryogenesis, supersymmetry, and higher dimensions in this program

  16. Juvenile Fibromyalgia: A Multidisciplinary Approach to Treatment.

    Science.gov (United States)

    Tesher, Melissa S

    2015-06-01

    A 14-year-old boy presented with months of severe widespread musculoskeletal pain. He was profoundly fatigued and unable to attend school. Laboratory evaluation, including complete blood count, comprehensive metabolic panel, inflammatory markers, and thyroid function, was unrevealing. Physical examination was also normal except for multiple tender points. The patient was diagnosed with juvenile primary fibromyalgia syndrome and referred for multidisciplinary treatment including physical therapy, exercise, and counseling, and his daily functioning gradually improves. Juvenile fibromyalgia is a complex syndrome that often severely limits patients' activities and can impede normal adolescent development. Effective treatment requires an understanding of the biologic, psychologic, and social factors contributing to the perpetuation of chronic pain. The author reviews the diagnostic criteria, pathophysiology, and treatment of juvenile fibromyalgia. Medications, particularly antidepressants and anticonvulsants, can be useful adjuncts to therapy. However, multimodal pain management including intensive physical therapy, exercise, counseling, and sleep hygiene is most effective in treating fibromyalgia. Copyright 2015, SLACK Incorporated.

  17. Current approaches in atrial fibrillation treatment

    Directory of Open Access Journals (Sweden)

    Cenk Sarı

    2014-09-01

    Full Text Available Atrial fibrillation (AF is the most common sustained arrhythmia encountered in clinical practice. Its incidence increases with age. AF is classified into subtypes according to the duration and/or able to provide sinus rhytym. İnitially, patients should be evaluated for rhythm or rate control for appropriate treatment. Second stage of strategy aimed to investigate the feasibility of anticoagulation therapy. Recently, due to the progress made in treatment with rhythm control and anticoagulation therapy, either American or European guidelines have been renovated. These developments have taken place in the newly published guide. In this article, the current change in the management of AF is discussed.

  18. Radiotherapy treatments using Tsallis entropy statistical approach

    International Nuclear Information System (INIS)

    Rodríguez-Pérez D; Sotolongo-Grau O; Sotolongo-Costa O; Antoranz J C

    2014-01-01

    Several radiobiological models mimic the biologic effect of one single radiation dose on a living tissue. However, the actual fractionated radiotherapy requires accounting for a new magnitude, i.e., time. Here, we explore the biological consequences posed by the mathematical prolongation of a previous single radiation model to fractionated treatment. The survival fraction is obtained, together with the equivalent physical dose, in terms of a time dependent factor (similar to a repair coefficient) describing the tissue trend to recovering its radioresistance. The model describes how dose fractions add up to obtain the equivalent dose and how the repair coefficient poses a limit to reach an equivalent dose equal to the critical one that would completely annihilate the tumor. On the other hand, the surrounding healthy tissue is a limiting factor to treatment planning. This tissue has its own repair coefficient and thus should limit the equivalent dose of a treatment. Depending on the repair coefficient and the critical dose of each tissue, unexpected results (failure to fully remove the tumor) can be obtained. To illustrate these results and predictions, some realistic example calculations will be performed using parameter values within actual clinical ranges. In conclusion, the model warns about treatment limitations and proposes ways to overcome them

  19. Unified electricity market

    International Nuclear Information System (INIS)

    Anon

    2011-01-01

    A unified European electricity market means a unification and harmonisation of functioning of the national electricity market into one European Market or into one entity. It gives an opportunity to Slovenske elektrarne to open room for their wider activity within Europe where common rules for cross-boarder trade and markets functioning will apply. (author)

  20. Unified field theory

    International Nuclear Information System (INIS)

    Prasad, R.

    1975-01-01

    Results of researches into Unified Field Theory over the past seven years are presented. The subject is dealt with in chapters entitled: the choice of affine connection, algebraic properties of the vector fields, field laws obtained from the affine connection based on the path integral method, application to quantum theory and cosmology, interpretation of physical theory in terms of geometry. (U.K.)

  1. Finite unified models

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Mondragon, M. (Technische Univ. Muenchen, Garching (Germany). Physik Dept.); Zoupanos, G. (National Technical Univ., Athens (Greece). Physics Dept.)

    1993-09-01

    We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

  2. Finite unified models

    International Nuclear Information System (INIS)

    Kapetanakis, D.; Mondragon, M.; Zoupanos, G.

    1993-01-01

    We present phenomenologically viable SU(5) unified models which are finite to all orders before the spontaneous symmetry breaking. In the case of two models with three families the top quark mass is predicted to be 178.8 GeV. (orig.)

  3. Comorbidities and treatment of trichotillomania systemic approach

    Directory of Open Access Journals (Sweden)

    Maričić Mina

    2016-01-01

    Full Text Available Introduction: Trichotillomania is a type of traumatic alopecia and is defined as the irresistible urge to pull out the hair. It is classified as impulse control disorder. This chronic, recurrent disorder with dermatologic expression has specific symptomatology, affects daily activities and leads to social isolation. Goal: The aim of the study was to investigate mannerism between symptoms in population with trichotillomania and to determine connection with other habits and disorders as well as treatment differences and efficiency. Material and methods: This prospective research was conducted within 880 people with trichotillomania from all around the world in a period from November 5th to December 15th, 2016. The data were collected by using a standardized internet questionnaire. Results: Symptoms of trichotillomania usually start between 9 and 13 years. 48,5% respondents localize their disorder on one specific body region. The most involved are scalp, eyebrows and eyelashes. 56,5% of the patients pull their hairs everyday, 61,6% even in company. Oral habits are present in 20,9%. Trichotillomania is associated with dermatillomania in 42.0%, nail biting habit in 37.0%, alcohol (21.7% and drug abuse (12.3%, anxiety (60.6%, affective (55.3%, obsessive-compulsive (19.4% and sleep disorders (11.3%. The most effective treatment seem to be combination of psychotherapy, antipsychotic and antidepressant. Conclusion: Trichotillomania shows diverse psychiatric appearance in most cases, so there is not specific treatment for this condition. It is necessary to treat trichotillomania with their comorbidities, especially the ones with oral habits, who present potential surgical patients.

  4. The Unified Theory of Physics

    OpenAIRE

    Chung, Ding-Yu

    2002-01-01

    The unified theory of physics unifies various phenomena in our observable universe and other universes. The unified theory is based on the zero-energy universe and the space-object structures. Different universes in different developmental stages are the different expressions of the space-object structures. The unified theory is divided into five parts: the space-object structures, cosmology, the periodic table of elementary particles, the galaxy formation, and the extreme force field. The sp...

  5. A unified transmission loss allocation method

    International Nuclear Information System (INIS)

    Ding, Qifeng; Abur, Ali

    2007-01-01

    A new unified method which allocates transmission losses either to buses in a pool market or to individual transactions in a bilateral contract market is presented in this paper. A detailed derivation of the method is given. A bus-loss matrix and a transaction-loss matrix are developed to show the interactions between bus injections and transactions. It is further demonstrated that the ''Physical-power-flow-based'' method can be obtained as an approximation of this unified approach under certain simplifying assumptions. Test systems are used to illustrate how the proposed method behaves under different possible scenarios. (author)

  6. Breast cancer treatment by nanophotolysis approach

    Science.gov (United States)

    Ashiq, Muhammad Gul Bahar

    2018-06-01

    In this work, gold nanoparticles irradiated with nanosecond short pulse laser for breast cancer treatment is studied theoretically. Nanophotolysis is involved for selective damaging of breast cancer cells. Results shows that laser fluence of 1.5 J/cm2 interact with gold nanoparticles and generates a maximum number of ions. Laser light in the visible region interacts with the gold foil. At 700 nm, 12 × 1012 ions are produced for the laser intensity of 8.89 × 107 W/cm2. Slow increase in the Coulomb explosion pressure from 0.6 × 106 Pa to 2 × 106 Pa is observed for a cluster size of range 10 nm to 20 nm. Penetration of nanobullets in tumor increases with the increase of temperature from 39.83 °C to 62.20 °C. Number of cell damaged increases by increasing the number of ions (6 × 1016 cells are damaged by 9.59 × 1020 gold ions). Findings are compared with the other experimental results and are found in excellent agreement. It is concluded from current work that nanophotolysis therapy is may be useful in future for selective damaging of breast cancer cells.

  7. Mialgias: Approaches to differential diagnosis, treatment

    Directory of Open Access Journals (Sweden)

    Nadezhda Aleksandrovna Shostak

    2013-01-01

    Full Text Available Differential diagnosis in muscle pains often presents great difficulties so all existing signs of the disease should be carefully considered to make its diagnosis and to prescribe adequate therapy. The paper considers the causes of muscle pains, laboratory and instrumental studies (immunological tests, determination of the level of specific muscular enzymes, primarily creatine phosphokinase – CPK, etc., and the main reasons for enhanced plasma CPK activity. It also describes acute and chronic mialgias associated with enhanced plasma CPK activity, as well as diseases in which mialgias are related to the normal level of CPK, myofascial syndrome (MFS and fibromyalgia (FM in particular. The characteristic features of MFS are given in its diagnostic criteria. It is stated that a differential diagnosis should be made between MFS and major muscle pain-associated abnormalities, such as polymyalgia rheumatica, FM, etc. Diagnosticcriteria for polymyalgia rheumatica are given. A MFS treatment algorithm is presented. Local exposure methods applied to altered musculoligamentous structures in combination with myorelaxants and non-steroidal anti-inflammatory drugs assume paramount importance in MFS.

  8. Clinical approach in treatment of resistant hypertension

    Directory of Open Access Journals (Sweden)

    Jennifer Frank

    2009-07-01

    Full Text Available Jennifer Frank, David SommerfeldUniversity of Wisconsin School of Medicine and Public Health, Department of Family Medicine, Appleton, WI, USAAbstract: Resistant hypertension, defined as failure to achieve target blood pressure despite the use of optimal or maximum doses of at least 3 agents, one of which is a diuretic, or requiring 4 or more medications to achieve blood pressure goal, is likely to affect up to 20% of all patients with hypertension. Apparent resistant hypertension may be caused by medication nonadherence, substances that either interfere with antihypertensive mediations or cause blood pressure elevation, and under- or inappropriate medication treatment. Certain patient characteristics are associated with the presence of resistant hypertension and include chronic kidney disease, diabetes, obesity, and presence of end-organ damage (microalbuminuria, retinopathy, left-ventricular hypertrophy. Secondary causes of resistant hypertension are not uncommon and include obstructive sleep apnea, chronic kidney disease, primary aldosteronism, renal artery stenosis, pheochromocytoma, and Cushing’s disease. Initial medication management usually includes adding or increasing the dose of a diuretic, which is effective in lowering the blood pressure of a large number of patients with resistant hypertension. Additional management options include maximizing lifestyle modification, combination therapy of antihypertensive agents depending on individual patient characteristics, adding less-commonly used fourth- or fifth-line antihypertensive agents, and referral to a hypertension specialist.Keywords: resistant hypertension, blood pressure, diuretic

  9. [Treatment approaches for synthetic drug addiction].

    Science.gov (United States)

    Kobayashi, Ohji

    2015-09-01

    In Japan, synthetic drugs have emerged since late 2000s, and cases of emergency visits and fatal traffic accidents due to acute intoxication have rapidly increased. The synthetic drugs gained popularity mainly because they were cheap and thought to be "legal". The Japanese government restricted not only production and distribution, but also its possession and use in April 2014. As the synthetic drug dependent patients have better social profiles compared to methamphetamine abusers, this legal sanction may have triggered the decrease in the number of synthetic drug dependent patient visits observed at Kanagawa Psychiatric Center since July 2014. Treatment of the synthetic drug dependent patients should begin with empathic inquiry into the motives and positive psychological effects of the drug use. In the maintenance phase, training patients to trust others and express their hidden negative emotions through verbal communications is essential. The recovery is a process of understanding the relationship between psychological isolation and drug abuse, and gaining trust in others to cope with negative emotions that the patients inevitably would face in their subsequent lives.

  10. A Holistic Treatment Approach to Male Erectile Disorder.

    Science.gov (United States)

    Millner, Vaughn S.; Ullery, Elizabeth K.

    2002-01-01

    This article offers information about erectile functioning, provides a DSM-IV-TR interpretation of erectile dysfunction, and discusses a biophysical approach to erectile dysfunction treatment. (Contains 36 references.) (GCP)

  11. IINTESTINAL COLIC IN INFANTS: APPROACHES TO THE COMPLEX TREATMENT

    Directory of Open Access Journals (Sweden)

    Yu. V. Rovenskaya

    2013-01-01

    Full Text Available The authors describe the causes and mechanisms of development of intestinal colic syndrome in infants and give the approaches to treatment of this condition with modern anti-foaming agents on the base of simethicone. 

  12. Grand unified theories

    International Nuclear Information System (INIS)

    Langacker, P.

    1981-01-01

    In this talk I discuss the present status of these theories and of their observational and experimental implications. In section II, I briefly review the standard SU 3 sup(c) x SU 2 x U 1 model of the strong and electroweak interactions. Although phenomenologically successful, the standard model leaves many questions unanswered. Some of these questions are addressed by grand unified theories, which are defined and discussed in Section III. The Georgi-Glashow SU 5 model is described, as are theories based on larger groups such as SO 10 , E 6 , or SO 16 . It is emphasized that there are many possible grand unified theories and that it is an experimental problem not only to test the basic ideas but to discriminate between models. (orig./HSI)

  13. A unified universe

    DEFF Research Database (Denmark)

    Codello, Alessandro; Jain, Rajeev Kumar

    2018-01-01

    We present a unified evolution of the universe from very early times until the present epoch by including both the leading local correction R2 and the leading non-local term R1□2R to the classical gravitational action. We find that the inflationary phase driven by R2 term gracefully exits...... in a transitory regime characterized by coherent oscillations of the Hubble parameter. The universe then naturally enters into a radiation dominated epoch followed by a matter dominated era. At sufficiently late times after radiation–matter equality, the non-local term starts to dominate inducing an accelerated...... expansion of the universe at the present epoch. We further exhibit the fact that both the leading local and non-local terms can be obtained within the covariant effective field theory of gravity. This scenario thus provides a unified picture of inflation and dark energy in a single framework by means...

  14. Operation Unified Protector

    DEFF Research Database (Denmark)

    Buhl, Kenneth Øhlenschlæger

    2012-01-01

    Formålet med denne artikel er at se nærmere på erfaringerne fra den maritime kampagne under den militære indsats i konflikten i Libyen i 2011, som i NATO regi blev kendt som Operation Unified Protector (OUP). Dækningen i de danske medier fokuserede primært på luftkampagnen, hvilket må tilskrives,...

  15. Unified Engineering Software System

    Science.gov (United States)

    Purves, L. R.; Gordon, S.; Peltzman, A.; Dube, M.

    1989-01-01

    Collection of computer programs performs diverse functions in prototype engineering. NEXUS, NASA Engineering Extendible Unified Software system, is research set of computer programs designed to support full sequence of activities encountered in NASA engineering projects. Sequence spans preliminary design, design analysis, detailed design, manufacturing, assembly, and testing. Primarily addresses process of prototype engineering, task of getting single or small number of copies of product to work. Written in FORTRAN 77 and PROLOG.

  16. Rational Unified Process

    OpenAIRE

    Kopal, Nils

    2016-01-01

    In this German seminar paper, which was written in the year 2011 at the University of Duisburg for a Bachelor Colloquium in Applied computer science, we show a brief overview of the Rational Unified Process (RUP). Thus, interested students or generally interested people in software development gain a first impression of RUP. The paper includes a survey and overview of the underlying process structure, the phases of the process, its workflows, and describes the always by the RUP developers pos...

  17. The Effectiveness of the Unified Protocol on Emotional Dysregulation and Cognitive Emotion Regulation Strategies in Patients with Psychosomatic Disorders

    Directory of Open Access Journals (Sweden)

    Mina Mazaheri

    2014-01-01

    Full Text Available Background: The unified treatment approach (UP is an emotion-focused cognitive-behavioral therapy in which the main object of treatment is emotional processes. The aim of the present research was to examine the effectiveness of The Unified Protocol (UP on emotional dysregulation and cognitive emotion regulation strategies in patients with psychosomatic disorders. Methods: Emotion-focused cognitive behavioral therapy (ECBT, a unified treatment, with 12 weekly group sessions of 2 hours, was presented to 14 patients with psychosomatic complaints at the Subspecialty Center of Psychiatry in Isfahan in 2013. Pre- and post-intervention assessments were done by means of the self-report tests of Difficulties in Emotion Regulation Scale (DERS and Cognitive Emotion Regulation Questionnaire (CERQ. Results: Significant reductions in post-test scores of total emotional dysregulation (P < 0.01 as well as the factors of non-acceptance (P < 0.05 and strategy (P < 0.01 were seen, while the other factors (goal, impulse, awareness, and clarity did not change. Moreover, a significant reduction was observed in the catastrophizing strategy score (P < 0.05, in comparison with other cognitive strategies. Conclusion: This pilot study including 14 patients with psychosomatic disorders indicates that the Unified treatment approach is an effective treatment in improvement of emotional dysregulation and in reduction of utilizing maladaptive cognitive strategies.

  18. SU-F-T-340: Direct Editing of Dose Volume Histograms: Algorithms and a Unified Convex Formulation for Treatment Planning with Dose Constraints

    Energy Technology Data Exchange (ETDEWEB)

    Ungun, B [Stanford University, Stanford, CA (United States); Stanford University School of Medicine, Stanford, CA (United States); Fu, A; Xing, L [Stanford University School of Medicine, Stanford, CA (United States); Boyd, S [Stanford University, Stanford, CA (United States)

    2016-06-15

    Purpose: To develop a procedure for including dose constraints in convex programming-based approaches to treatment planning, and to support dynamic modification of such constraints during planning. Methods: We present a mathematical approach that allows mean dose, maximum dose, minimum dose and dose volume (i.e., percentile) constraints to be appended to any convex formulation of an inverse planning problem. The first three constraint types are convex and readily incorporated. Dose volume constraints are not convex, however, so we introduce a convex restriction that is related to CVaR-based approaches previously proposed in the literature. To compensate for the conservatism of this restriction, we propose a new two-pass algorithm that solves the restricted problem on a first pass and uses this solution to form exact constraints on a second pass. In another variant, we introduce slack variables for each dose constraint to prevent the problem from becoming infeasible when the user specifies an incompatible set of constraints. We implement the proposed methods in Python using the convex programming package cvxpy in conjunction with the open source convex solvers SCS and ECOS. Results: We show, for several cases taken from the clinic, that our proposed method meets specified constraints (often with margin) when they are feasible. Constraints are met exactly when we use the two-pass method, and infeasible constraints are replaced with the nearest feasible constraint when slacks are used. Finally, we introduce ConRad, a Python-embedded free software package for convex radiation therapy planning. ConRad implements the methods described above and offers a simple interface for specifying prescriptions and dose constraints. Conclusion: This work demonstrates the feasibility of using modifiable dose constraints in a convex formulation, making it practical to guide the treatment planning process with interactively specified dose constraints. This work was supported by the

  19. SU-F-T-340: Direct Editing of Dose Volume Histograms: Algorithms and a Unified Convex Formulation for Treatment Planning with Dose Constraints

    International Nuclear Information System (INIS)

    Ungun, B; Fu, A; Xing, L; Boyd, S

    2016-01-01

    Purpose: To develop a procedure for including dose constraints in convex programming-based approaches to treatment planning, and to support dynamic modification of such constraints during planning. Methods: We present a mathematical approach that allows mean dose, maximum dose, minimum dose and dose volume (i.e., percentile) constraints to be appended to any convex formulation of an inverse planning problem. The first three constraint types are convex and readily incorporated. Dose volume constraints are not convex, however, so we introduce a convex restriction that is related to CVaR-based approaches previously proposed in the literature. To compensate for the conservatism of this restriction, we propose a new two-pass algorithm that solves the restricted problem on a first pass and uses this solution to form exact constraints on a second pass. In another variant, we introduce slack variables for each dose constraint to prevent the problem from becoming infeasible when the user specifies an incompatible set of constraints. We implement the proposed methods in Python using the convex programming package cvxpy in conjunction with the open source convex solvers SCS and ECOS. Results: We show, for several cases taken from the clinic, that our proposed method meets specified constraints (often with margin) when they are feasible. Constraints are met exactly when we use the two-pass method, and infeasible constraints are replaced with the nearest feasible constraint when slacks are used. Finally, we introduce ConRad, a Python-embedded free software package for convex radiation therapy planning. ConRad implements the methods described above and offers a simple interface for specifying prescriptions and dose constraints. Conclusion: This work demonstrates the feasibility of using modifiable dose constraints in a convex formulation, making it practical to guide the treatment planning process with interactively specified dose constraints. This work was supported by the

  20. Approach to osteomyelitis treatment with antibiotic loaded PMMA.

    Science.gov (United States)

    Wentao, Zhang; Lei, Guangyu; Liu, Yang; Wang, Wei; Song, Tao; Fan, Jinzhu

    2017-01-01

    To reduce the incidence of osteomyelitis infection, local antibiotic impregnated delivery systems are commonly used as a promising and effective approach to deliver high antibiotic concentrations at the infection site. The objective of this review was to provide a literature review regarding approach to osteomyelitis treatment with antibiotic loaded PMMA. Literature study regarding osteomyelitis treatment with antibiotic loaded carriers using key terms Antibiotic, osteomyelitis, biodegradable PMMA through published articles. Hands searching of bibliographies of identified articles were also undertaken. We concluded that Antibiotic-impregnated PMMA beads are useful options for the treatment of osteomyelitis for prolonged drug therapy. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Unifying the field: developing an integrative paradigm for behavior therapy.

    Science.gov (United States)

    Eifert, G H; Forsyth, J P; Schauss, S L

    1993-06-01

    The limitations of early conditioning models and treatments have led many behavior therapists to abandon conditioning principles and replace them with loosely defined cognitive theories and treatments. Systematic theory extensions to human behavior, using new concepts and processes derived from and built upon the basic principles, could have prevented the divisive debates over whether psychological dysfunctions are the results of conditioning or cognition and whether they should be treated with conditioning or cognitive techniques. Behavior therapy could also benefit from recent advances in experimental cognitive psychology that provide objective behavioral methods of studying dysfunctional processes. We suggest a unifying paradigm for explaining abnormal behavior that links and integrates different fields of study and processes that are frequently believed to be incompatible or antithetical such as biological vulnerability variables, learned behavioral repertoires, and that also links historical and current antecedents of the problem. An integrative paradigmatic behavioral approach may serve a unifying function in behavior therapy (a) by promoting an understanding of the dysfunctional processes involved in different disorders and (b) by helping clinicians conduct functional analyses that lead to theory-based, individualized, and effective treatments.

  2. WE-H-BRC-06: A Unified Machine-Learning Based Probabilistic Model for Automated Anomaly Detection in the Treatment Plan Data

    International Nuclear Information System (INIS)

    Chang, X; Liu, S; Kalet, A; Yang, D

    2016-01-01

    Purpose: The purpose of this work was to investigate the ability of a machine-learning based probabilistic approach to detect radiotherapy treatment plan anomalies given initial disease classes information. Methods In total we obtained 1112 unique treatment plans with five plan parameters and disease information from a Mosaiq treatment management system database for use in the study. The plan parameters include prescription dose, fractions, fields, modality and techniques. The disease information includes disease site, and T, M and N disease stages. A Bayesian network method was employed to model the probabilistic relationships between tumor disease information, plan parameters and an anomaly flag. A Bayesian learning method with Dirichlet prior was useed to learn the joint probabilities between dependent variables in error-free plan data and data with artificially induced anomalies. In the study, we randomly sampled data with anomaly in a specified anomaly space.We tested the approach with three groups of plan anomalies – improper concurrence of values of all five plan parameters and values of any two out of five parameters, and all single plan parameter value anomalies. Totally, 16 types of plan anomalies were covered by the study. For each type, we trained an individual Bayesian network. Results: We found that the true positive rate (recall) and positive predictive value (precision) to detect concurrence anomalies of five plan parameters in new patient cases were 94.45±0.26% and 93.76±0.39% respectively. To detect other 15 types of plan anomalies, the average recall and precision were 93.61±2.57% and 93.78±3.54% respectively. The computation time to detect the plan anomaly of each type in a new plan is ∼0.08 seconds. Conclusion: The proposed method for treatment plan anomaly detection was found effective in the initial tests. The results suggest that this type of models could be applied to develop plan anomaly detection tools to assist manual and

  3. WE-H-BRC-06: A Unified Machine-Learning Based Probabilistic Model for Automated Anomaly Detection in the Treatment Plan Data

    Energy Technology Data Exchange (ETDEWEB)

    Chang, X; Liu, S [Washington University in St. Louis, St. Louis, MO (United States); Kalet, A [University of Washington Medical Center, Seattle, WA (United States); Yang, D [Washington University in St Louis, St Louis, MO (United States)

    2016-06-15

    Purpose: The purpose of this work was to investigate the ability of a machine-learning based probabilistic approach to detect radiotherapy treatment plan anomalies given initial disease classes information. Methods In total we obtained 1112 unique treatment plans with five plan parameters and disease information from a Mosaiq treatment management system database for use in the study. The plan parameters include prescription dose, fractions, fields, modality and techniques. The disease information includes disease site, and T, M and N disease stages. A Bayesian network method was employed to model the probabilistic relationships between tumor disease information, plan parameters and an anomaly flag. A Bayesian learning method with Dirichlet prior was useed to learn the joint probabilities between dependent variables in error-free plan data and data with artificially induced anomalies. In the study, we randomly sampled data with anomaly in a specified anomaly space.We tested the approach with three groups of plan anomalies – improper concurrence of values of all five plan parameters and values of any two out of five parameters, and all single plan parameter value anomalies. Totally, 16 types of plan anomalies were covered by the study. For each type, we trained an individual Bayesian network. Results: We found that the true positive rate (recall) and positive predictive value (precision) to detect concurrence anomalies of five plan parameters in new patient cases were 94.45±0.26% and 93.76±0.39% respectively. To detect other 15 types of plan anomalies, the average recall and precision were 93.61±2.57% and 93.78±3.54% respectively. The computation time to detect the plan anomaly of each type in a new plan is ∼0.08 seconds. Conclusion: The proposed method for treatment plan anomaly detection was found effective in the initial tests. The results suggest that this type of models could be applied to develop plan anomaly detection tools to assist manual and

  4. Unified approach to catastrophic events: from the normal state to geological or biological shock in terms of spectral fractal and nonlinear analysis

    Directory of Open Access Journals (Sweden)

    K. A. Eftaxias

    2006-01-01

    Full Text Available An important question in geophysics is whether earthquakes (EQs can be anticipated prior to their occurrence. Pre-seismic electromagnetic (EM emissions provide a promising window through which the dynamics of EQ preparation can be investigated. However, the existence of precursory features in pre-seismic EM emissions is still debatable: in principle, it is difficult to prove associations between events separated in time, such as EQs and their EM precursors. The scope of this paper is the investigation of the pre-seismic EM activity in terms of complexity. A basic reason for our interest in complexity is the striking similarity in behavior close to irreversible phase transitions among systems that are otherwise quite different in nature. Interestingly, theoretical studies (Hopfield, 1994; Herz and Hopfield 1995; Rundle et al., 1995; Corral et al., 1997 suggest that the EQ dynamics at the final stage and neural seizure dynamics should have many similar features and can be analyzed within similar mathematical frameworks. Motivated by this hypothesis, we evaluate the capability of linear and non-linear techniques to extract common features from brain electrical activities and pre-seismic EM emissions predictive of epileptic seizures and EQs respectively. The results suggest that a unified theory may exist for the ways in which firing neurons and opening cracks organize themselves to produce a large crisis, while the preparation of an epileptic shock or a large EQ can be studied in terms of ''Intermittent Criticality''.

  5. Unified Symmetry of Hamilton Systems

    International Nuclear Information System (INIS)

    Xu Xuejun; Qin Maochang; Mei Fengxiang

    2005-01-01

    The definition and the criterion of a unified symmetry for a Hamilton system are presented. The sufficient condition under which the Noether symmetry is a unified symmetry for the system is given. A new conserved quantity, as well as the Noether conserved quantity and the Hojman conserved quantity, deduced from the unified symmetry, is obtained. An example is finally given to illustrate the application of the results.

  6. Beyond the Unified Model

    Science.gov (United States)

    Frauendorf, S.

    2018-04-01

    The key elements of the Unified Model are reviewed. The microscopic derivation of the Bohr Hamiltonian by means of adiabatic time-dependent mean field theory is presented. By checking against experimental data the limitations of the Unified Model are delineated. The description of the strong coupling between the rotational and intrinsic degrees of freedom in framework of the rotating mean field is presented from a conceptual point of view. The classification of rotational bands as configurations of rotating quasiparticles is introduced. The occurrence of uniform rotation about an axis that differs from the principle axes of the nuclear density distribution is discussed. The physics behind this tilted-axis rotation, unknown in molecular physics, is explained on a basic level. The new symmetries of the rotating mean field that arise from the various orientations of the angular momentum vector with respect to the triaxial nuclear density distribution and their manifestation by the level sequence of rotational bands are discussed. Resulting phenomena, as transverse wobbling, rotational chirality, magnetic rotation and band termination are discussed. Using the concept of spontaneous symmetry breaking the microscopic underpinning of the rotational degrees is refined.

  7. Rapid detox: understanding new treatment approaches for the addicted patient.

    Science.gov (United States)

    McCabe, S

    2000-01-01

    Despite substantive advances in understanding of genetic and biochemical basis of substance abuse and addiction in the last decade, little information has been translated into alternative treatment models for the addicted patient. Rapid detox, an alternative form of detox treatment, is gaining in both acceptance and popularity. To increase readers' understanding of the neurobiology of addiction and the mode of action of new detox approaches for patients addicted to opiate drugs. A review of the current literature pertaining to rapid detox. Rapid detox is a viable alternative for selected patients attempting to detox from opiate agents of abuse. Increasing knowledge of new treatment approaches allows nurses working to assist addicted patients in planning and receiving treatment based on new awareness of the neurobiology of addiction.

  8. Holistic approach to treatment of intractable central neuropathic itch.

    Science.gov (United States)

    Curtis, Ashley R; Tegeler, Charles; Burdette, Jonathan; Yosipovitch, Gil

    2011-05-01

    Central neuropathic itch can be a lifelong debilitating condition and treatment challenge. We report a patient with a traumatic brain injury with severe intractable pruritus who failed extensive pharmacologic and nonpharmacologic treatment but responded to a holistic approach using healing touch. We discuss the complexity of this type of neuropathic itch and present a holistic approach as an adjunct to therapy in reducing itch intensity. This case presentation along with the literature discussed suggests a therapeutic strategy for the management of complicated central neuropathic itch. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  9. Evolution of transoral approaches, endoscopic endonasal approaches, and reduction strategies for treatment of craniovertebral junction pathology: a treatment algorithm update.

    Science.gov (United States)

    Dlouhy, Brian J; Dahdaleh, Nader S; Menezes, Arnold H

    2015-04-01

    The craniovertebral junction (CVJ), or the craniocervical junction (CCJ) as it is otherwise known, houses the crossroads of the CNS and is composed of the occipital bone that surrounds the foramen magnum, the atlas vertebrae, the axis vertebrae, and their associated ligaments and musculature. The musculoskeletal organization of the CVJ is unique and complex, resulting in a wide range of congenital, developmental, and acquired pathology. The refinements of the transoral approach to the CVJ by the senior author (A.H.M.) in the late 1970s revolutionized the treatment of CVJ pathology. At the same time, a physiological approach to CVJ management was adopted at the University of Iowa Hospitals and Clinics in 1977 based on the stability and motion dynamics of the CVJ and the site of encroachment, incorporating the transoral approach for irreducible ventral CVJ pathology. Since then, approaches and techniques to treat ventral CVJ lesions have evolved. In the last 40 years at University of Iowa Hospitals and Clinics, multiple approaches to the CVJ have evolved and a better understanding of CVJ pathology has been established. In addition, new reduction strategies that have diminished the need to perform ventral decompressive approaches have been developed and implemented. In this era of surgical subspecialization, to properly treat complex CVJ pathology, the CVJ specialist must be trained in skull base transoral and endoscopic endonasal approaches, pediatric and adult CVJ spine surgery, and must understand and be able to treat the complex CSF dynamics present in CVJ pathology to provide the appropriate, optimal, and tailored treatment strategy for each individual patient, both child and adult. This is a comprehensive review of the history and evolution of the transoral approaches, extended transoral approaches, endoscopie assisted transoral approaches, endoscopie endonasal approaches, and CVJ reduction strategies. Incorporating these advancements, the authors update the

  10. [Evaluated treatment approaches in child and adolescent psychiatry I].

    Science.gov (United States)

    Baving, L; Schmidt, M H

    2001-08-01

    The principle of evidence-based medicine is to integrate data concerning the efficacy of interventions into clinical practice. This article assesses the level of evaluation of psychosocial, psychopharmacological and combined interventions for mental disorders in childhood and adolescence (autistic disorders, hyperkinetic disorders, conduct disorders, tic disorders, enuresis, and encopresis). Three different levels of evaluation were defined for both psychosocial and psychopharmacological interventions: A (> or = 2 randomized controlled studies), B (1 randomized controlled study), and C (open studies and case studies). The level of evaluation was judged on the basis of original papers found in a comprehensive literature search. For most disorders presented in this article there are several A-level treatments. The efficacy of both psychosocial and psychopharmacological interventions that target specific problem behaviors or symptoms, respectively, has been repeatedly demonstrated with regard to autistic disorders. Many studies have evaluated treatment approaches for hyperkinetic disorders and conduct disorders. With regard to the treatment of tic disorders in children and adolescents, far more studies evaluated the efficacy of pharmacotherapy than of psychotherapy. Further research should compare the efficacy of different treatment approaches, examine specific and differential treatment effects and investigate combined treatment approaches.

  11. Systemic multimodal approach to speech therapy treatment in autistic children.

    Science.gov (United States)

    Tamas, Daniela; Marković, Slavica; Milankov, Vesela

    2013-01-01

    Conditions in which speech therapy treatment is applied in autistic children are often not in accordance with characteristics of opinions and learning of people with autism. A systemic multimodal approach means motivating autistic people to develop their language speech skill through the procedure which allows reliving of their personal experience according to the contents that are presented in the their natural social environment. This research was aimed at evaluating the efficiency of speech treatment based on the systemic multimodal approach to the work with autistic children. The study sample consisted of 34 children, aged from 8 to 16 years, diagnosed to have different autistic disorders, whose results showed a moderate and severe clinical picture of autism on the Childhood Autism Rating Scale. The applied instruments for the evaluation of ability were the Childhood Autism Rating Scale and Ganzberg II test. The study subjects were divided into two groups according to the type of treatment: children who were covered by the continuing treatment and systemic multimodal approach in the treatment, and children who were covered by classical speech treatment. It is shown that the systemic multimodal approach in teaching autistic children affects the stimulation of communication, socialization, self-service and work as well as that the progress achieved in these areas of functioning was retainable after long time, too. By applying the systemic multimodal approach when dealing with autistic children and by comparing their achievements on tests applied before, during and after the application of this mode, it has been concluded that certain improvement has been achieved in the functionality within the diagnosed category. The results point to a possible direction in the creation of new methods, plans and programs in dealing with autistic children based on empirical and interactive learning.

  12. MULTIDISCIPLINARY APPROACH TO SUPPORTING TREATMENT COMPLIANCE IN TUBERCULOSIS PATIENTS

    Directory of Open Access Journals (Sweden)

    T. V. Sherstneva

    2017-01-01

    Full Text Available The article presents the algorithm for working with tuberculosis patients in TB hospital, providing implementation of multidisciplinary patient-centered activities for early diagnostics of psychiatric and social disorders, therapy and rehabilitation of concurrent psychiatric disorders and addictions. Multidisciplinary approach to activities within TB unit is aimed at improvement of treatment compliance of tuberculosis patients. The training programme has been developed in order to improve competency of medical personnel on the issue of treatment interruption prevention and motivating patients to undergo the continuous treatment.

  13. Breast cancer treatment: historical review and current approaches

    International Nuclear Information System (INIS)

    Kulakowski, A.

    1994-01-01

    The evolution and development of opinions on the diagnosis and treatment of breast cancer since Galen to present time is presented. The concept of breast cancer as a local disease has been replaced by the understanding of its systemic character. On this background described are the methods of surgical treatment beginning from early - supraradical, to present -conservative approaches. The ''milestones'' in diagnosis and treatment of breast cancer of the last 40 years are presented. Current methods of breast cancer management include correct diagnosis (clinical examination, mammography, ultrasound, fine needle aspiration biopsy), TNM staging, adequate loco-regional therapy, systemic therapy, rehabilitation, reconstruction and careful follow-up. (author)

  14. Meseron Therapy: An African Approach To Psychological Treatment ...

    African Journals Online (AJOL)

    Meseron therapy is a psychological treatment approach of African origin that consists of a direct and holistic counter-attack on undesirable conditions. It derives from an African custom of rejecting the negative while accepting the positive circumstances of life. Based on the philosophy of “I can”, and the concept of man as a ...

  15. The stochastic system approach for estimating dynamic treatments effect.

    Science.gov (United States)

    Commenges, Daniel; Gégout-Petit, Anne

    2015-10-01

    The problem of assessing the effect of a treatment on a marker in observational studies raises the difficulty that attribution of the treatment may depend on the observed marker values. As an example, we focus on the analysis of the effect of a HAART on CD4 counts, where attribution of the treatment may depend on the observed marker values. This problem has been treated using marginal structural models relying on the counterfactual/potential response formalism. Another approach to causality is based on dynamical models, and causal influence has been formalized in the framework of the Doob-Meyer decomposition of stochastic processes. Causal inference however needs assumptions that we detail in this paper and we call this approach to causality the "stochastic system" approach. First we treat this problem in discrete time, then in continuous time. This approach allows incorporating biological knowledge naturally. When working in continuous time, the mechanistic approach involves distinguishing the model for the system and the model for the observations. Indeed, biological systems live in continuous time, and mechanisms can be expressed in the form of a system of differential equations, while observations are taken at discrete times. Inference in mechanistic models is challenging, particularly from a numerical point of view, but these models can yield much richer and reliable results.

  16. Direction: unified theory of interactions

    International Nuclear Information System (INIS)

    Valko, P.

    1987-01-01

    Briefly characterized are the individual theories, namely, the general relativity theory, the Kaluza-Klein theory, the Weyl theory, the unified theory of electromagnetic and weak interactions, the supergravity theory, and the superstring theory. The history is recalled of efforts aimed at creating a unified theory of interactions, and future prospects are outlined. (M.D.). 2 figs

  17. Grand unified theories. Pt. 2

    International Nuclear Information System (INIS)

    Ellis, J.

    1982-01-01

    The author gives an introduction to the construction of grand unified theories on the base of the SU(3)xSU(2)xU(1) model of the strong, weak, and electromagnetic interactions. Especially he discusses the proton decay, neutrino masses and oscillations, and cosmological implications in connection with grand unified theories. (orig./HSI)

  18. Clinical Significance: a Therapeutic Approach Topsychological Assessment in Treatment Planning

    Directory of Open Access Journals (Sweden)

    Afolabi Olusegun Emmanuel

    2015-06-01

    Full Text Available Psychological assessment has long been reported as a key component of clinical psychology. This paper examines the complexities surrounding the clinical significance of therapeutic approach to treatment planning. To achieve this objective, the paper searched and used the PsycINFO and PubMed databases and the reference sections of chapters and journal articles to analysed, 1 a strong basis for the usage of therapeutic approach to psychological assessment in treatment plans, 2 explained the conceptual meaning of clinical significant change in therapeutic assessment, 3 answered some of the questions regarding practicability and the clinical significance of therapeutic approach to treatment plans, particularly during or before treatment, 4 linked therapeutic assessment to change in clients’ clinical impression, functioning and therapeutic needs 5 analysed the empirically documenting clinically significant change in therapeutic assessment. Finally, the study suggested that though therapeutic assessment is not sufficient for the systematic study of psychotherapy outcome and process, it is still consistent with both the layman and professional expectations regarding treatment outcome and also provides a precise method for classifying clients as ‘changed’ or ‘unchanged’ on the basis of clinical significance criteria.

  19. Open Issues in Supervisory Control of Hybrid Electric Vehicles: A Unified Approach Using Optimal Control Methods Questions ouvertes sur la supervision énergétique des véhicules hybrides électriques : une approche unifiée par la théorie de la commande optimale

    Directory of Open Access Journals (Sweden)

    Serrao L.

    2013-03-01

    Full Text Available Energy management of hybrid propulsion systems is considered, presenting new issues that extend the energy management role beyond the standard torque splitting to maximize system efficiency. The new issues include additional optimization criteria, constraints and relevant dynamics to deal with. New optimization criteria in addition the sole fuel consumption minimization include engine-out pollutant emissions and battery aging. State constraints are modified to account for plug-in hybrid vehicles. Moreover, specific supervisory control problems are recognized to need additional state variables. The latter comprise: engine and catalyst temperature to deal with engine warm-up effects on fuel consumption and after-catalyst emissions; thermal dynamics of heat recovery systems (Rankine or Thermo-Electric Generators, TEGs; and battery temperature, which influences battery performance and aging. It is shown that all these control problems can be treated in an unified fashion by extending the well-known ECMS (Equivalent Consumption Minimization Strategy, which is an implementation of Pontryagin Minimum Principle (PMP as formulated by optimal control theory. Extended definitions of the Hamiltonian function and Lagrange multipliers are introduced. Optimization runs performed off line are reported. Results show the benefits of the proposed unified approach and enlighten some first online implementation issues. Cet article a pour objet la gestion optimale de l’énergie pour un système de propulsion hybride. Le problème traditionnel de répartition de la puissance est modifié avec des nouveaux objectifs d’optimisation et des nouvelles contraintes. Les nouveaux objectifs d’optimisation incluent les émissions de polluants et le vieillissement de la batterie. Les contraintes sont modifiées pour prendre en compte des batteries à recharge externe (hybrides plug-in. De plus, des problèmes spécifiques sont traités avec une modélisation plus d

  20. Placebo treatment facilitates social trust and approach behavior.

    Science.gov (United States)

    Yan, Xinyuan; Yong, Xue; Huang, Wenhao; Ma, Yina

    2018-05-29

    Placebo effect refers to beneficial changes induced by the use of inert treatment, such as placebo-induced relief of physical pain and attenuation of negative affect. To date, we know little about whether placebo treatment could facilitate social functioning, a crucial aspect for well-being of a social species. In the present study, we develop and validate a paradigm to induce placebo effects on social trust and approach behavior (social placebo effect), and show robust evidence that placebo treatment promotes trust in others and increases preference for a closer interpersonal distance. We further examine placebo effects in real-life social interaction and show that placebo treatment makes single, but not pair-bonded, males keep closer to an attractive first-met female and perceive less social anxiety in the female. Finally, we show evidence that the effects of placebo treatment on social trust and approach behavior can be as strong as the effect of intranasal administration of oxytocin, a neuropeptide known for its function in facilitating social cognition and behavior. The finding of the social placebo effect extends our understanding of placebo effects on improvement of physical, mental, and social well-being and suggests clinical potentials in the treatment of social dysfunction.

  1. A unified metabolism for Mars: A new approach developed from research on extraterrestrial life detection by enzymatically induced exchange of O 18

    Science.gov (United States)

    1972-01-01

    A general graded life detection approach ranging from environmental and in situ observations to specific metabolic experiments on Mars is reported. A zero dead volume leak and computer mediated data acquisition system is also discussed. Soil analyses were also conducted.

  2. Combined endoscopic approaches to the cardiac sphincter achalasia treatment

    Directory of Open Access Journals (Sweden)

    V. N. Klimenko

    2015-12-01

    Full Text Available Aim. To assess combined endoscopic approaches to the cardiac sphincter achalasia treatment. Results. There are preliminary results of treatment and methods of carrying out of combined endoscopic pneumocardiodilatation and injections of botulotoxin type A ‘Disport’ at achalasia cardia are described in the article. Aethio-pathogenetic aspects in the development of achalasia cardia, action of botulotoxin type A and balloon pneumocardiodilatation of the esophagus, were described. And modern roentgen-endoscopic classification of achalasia cardia was given. Prognostic estimation scale of possibility to implement further combined endoscopic or surgical treatment is defined and is being in subsequent working out. Conclusion. Described clinical cases most brightly demonstrate variety of clinical achalasia cardia manifestations and also determine of the earlier display of surgical treatment.

  3. Treatment for spasmodic dysphonia: limitations of current approaches

    Science.gov (United States)

    Ludlow, Christy L.

    2009-01-01

    Purpose of review Although botulinum toxin injection is the gold standard for treatment of spasmodic dysphonia, surgical approaches aimed at providing long-term symptom control have been advancing over recent years. Recent findings When surgical approaches provide greater long-term benefits to symptom control, they also increase the initial period of side effects of breathiness and swallowing difficulties. However, recent analyses of quality-of-life questionnaires in patients undergoing regular injections of botulinum toxin demonstrate that a large proportion of patients have limited relief for relatively short periods due to early breathiness and loss-of-benefit before reinjection. Summary Most medical and surgical approaches to the treatment of spasmodic dysphonia have been aimed at denervation of the laryngeal muscles to block symptom expression in the voice, and have both adverse effects as well as treatment benefits. Research is needed to identify the central neuropathophysiology responsible for the laryngeal muscle spasms in order target treatment towards the central neurological abnormality responsible for producing symptoms. PMID:19337127

  4. Lattice mechanics of ionic crystals - unified study

    International Nuclear Information System (INIS)

    Sengupta, S.; Roy, D.; Basu, A.N.

    1979-01-01

    The up-to-date situation in the understanding of the mechanical properties of ionic solids is reviewed. These properties are determined by the Born-Oppenheimer (B-O) potential energy function. For ionic crystals this potential energy function can be written down with some precision. To keep the expression tractable, the dominant electron deformation, the dipolar deformation, is treated as an adiabatic variable and the energy then becomes a function of both the nuclear coordinates and the ionic dipole moments. All the well known models for ionic crystals are discussed in terms of the energy expression they imply. This makes the comparison straight forward and brings out the essential difference between the models clearly. Next various quantum mechanical treatments for ionic crystals are reviewed. An attempt is made to obtain the B-O potential energy expression using a Heitler-London approach. By comparing the various models one can arrive at some definitive conclusions about the degree of validity and the assumptions underlying these models. Finally a comprehensive review of the results of actual computation on various ionic crystals done by different authors is undertaken. The crucial quantitative results are examined and the success and shortcoming of each calculation are critically analysed. The guiding principle in this part is the unified approach. i.e. to see how far a model with a given set of parameters accounts for both the dynamic and static properties. The discussion is divided in three sections for crystals with sodium chloride, cesium chloride and zinc sulfide structures. Outstanding problems and difficulties in the present understanding are pointed out. (auth.)

  5. NEW APPROACH TO TREATMENT OF CHRONIC CONSTIPATION IN CHILDREN

    Directory of Open Access Journals (Sweden)

    A.V. Gorelov

    2009-01-01

    Full Text Available Authors discuss the problem of constipation in children and modern approach to treatment and prophylaxis of this disorder in children of different age group. Stimulating effectiveness of laxative agents and spasmolytics are analyzed. Effectiveness of sodium picosulfate (Guttalax in monotherapy was compared with combined treatment with sodium picosulfate and spasmolytic (Buscopan in children with chronic constipation.Key words: children, chronic constipation, sodium picosulfate, hyoscine butylbromide.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(1:85-89

  6. Seven Deadliest Unified Communications Attacks

    CERN Document Server

    York, Dan

    2010-01-01

    Do you need to keep up with the latest hacks, attacks, and exploits effecting Unified Communications technology? Then you need Seven Deadliest Unified Communication Attacks. This book pinpoints the most dangerous hacks and exploits specific to Unified Communications, laying out the anatomy of these attacks including how to make your system more secure. You will discover the best ways to defend against these vicious hacks with step-by-step instruction and learn techniques to make your computer and network impenetrable. Attacks featured in this book include: UC Ecosystem Attacks Insecure Endpo

  7. New approaches to addiction treatment based on learning and memory.

    Science.gov (United States)

    Kiefer, Falk; Dinter, Christina

    2013-01-01

    Preclinical studies suggest that physiological learning processes are similar to changes observed in addicts at the molecular, neuronal, and structural levels. Based on the importance of classical and instrumental conditioning in the development and maintenance of addictive disorders, many have suggested cue-exposure-based extinction training of conditioned, drug-related responses as a potential new treatment of addiction. It may also be possible to facilitate this extinction training with pharmacological compounds that strengthen memory consolidation during cue exposure. Another potential therapeutic intervention would be based on the so-called reconsolidation theory. According to this hypothesis, already-consolidated memories return to a labile state when reactivated, allowing them to undergo another phase of consolidation-reconsolidation, which can be pharmacologically manipulated. These approaches suggest that the extinction of drug-related memories may represent a viable treatment strategy in the future treatment of addiction.

  8. General unifying features of controlled quantum phenomena

    International Nuclear Information System (INIS)

    Pechen, Alexander; Brif, Constantin; Wu, Rebing; Chakrabarti, Raj; Rabitz, Herschel

    2010-01-01

    Many proposals have been put forth for controlling quantum phenomena, including open-loop, adaptive feedback, and real-time feedback control. Each of these approaches has been viewed as operationally, and even physically, distinct from the others. This work shows that all such scenarios inherently share the same fundamental control features residing in the topology of the landscape relating the target physical observable to the applied controls. This unified foundation may provide a basis for development of hybrid control schemes that would combine the advantages of the existing approaches to achieve the best overall performance.

  9. UPQC (Unified power Quality Conditioner)

    Indian Academy of Sciences (India)

    First page Back Continue Last page Graphics. UPQC (Unified power Quality Conditioner). Hybrid of Shunt and Series compensator. Compensate both Current Quality and Voltage Quality. Costlier Solution as it involves two set of Inverters.

  10. A unified monolithic approach for multi-fluid flows and fluid-structure interaction using the Particle Finite Element Method with fixed mesh

    Science.gov (United States)

    Becker, P.; Idelsohn, S. R.; Oñate, E.

    2015-06-01

    This paper describes a strategy to solve multi-fluid and fluid-structure interaction (FSI) problems using Lagrangian particles combined with a fixed finite element (FE) mesh. Our approach is an extension of the fluid-only PFEM-2 (Idelsohn et al., Eng Comput 30(2):2-2, 2013; Idelsohn et al., J Numer Methods Fluids, 2014) which uses explicit integration over the streamlines to improve accuracy. As a result, the convective term does not appear in the set of equations solved on the fixed mesh. Enrichments in the pressure field are used to improve the description of the interface between phases.

  11. Model of unified gauge fields

    International Nuclear Information System (INIS)

    Leite Lopes, J.

    1998-04-01

    In this work, we discuss the physical ideas which represents the basis for the unified gauge field model. Despite of the difficulties that we presently have for embodying in a natural manner muons and hadrons in that model, we have the feeling that we are on the way which seems to lead to the construction of a theory in which the Maxwell electromagnetic field and the Fermi weak interaction field are manifestations of a unique subjacent physical entity - the unified gauge fields. (author)

  12. Contemporary diagnostic imaging approaches in treatment of urolithiasis

    International Nuclear Information System (INIS)

    Velichkov, B.; Naoumov, N.

    2004-01-01

    Based on an extensive review of the literature and on their own clinical experience, authors attempts to present clear guidelines for the management of urolithiasis. Ninety-eight per cent of stones can be successfully fragmented by the application of shock-waves, but the ability of the kidney and ureter to clear the resulting fragments is far more important in terms of successful treatment outcome. Extracorporeal shock-waves lithotripsy (ESWL) is a safe procedure for the treatment of urolithiasis; nevertheless some problems remain. In ureteric stones, ureteroscopy (rigid or flexible device) allows a rate of stone-free patients better than ESWL. For treatment of large staghorn calculi combined approach of Percutaneous Nephrolithotripsy (PCNL) and ESWL is preferred. For stones located at lower calyx, the stone-free rate in patients treated by ESWL fell to 50%, when unfavourable anatomy is present. Ultimate goal of treating stones by whatever means is to get the patient stone-free and prevent recurrence. The good technique of performing and interpretation of diagnostic imaging modalities is of critical importance in terms of diagnosing, successful treatment and follow up of results of treatment of urolithiasis

  13. Oral nanomedicine approaches for the treatment of psychiatric illnesses.

    Science.gov (United States)

    Dening, Tahnee J; Rao, Shasha; Thomas, Nicky; Prestidge, Clive A

    2016-02-10

    Psychiatric illnesses are a leading cause of disability and morbidity globally. However, the preferred orally dosed pharmacological treatment options available for depression, anxiety and schizophrenia are often limited by factors such as low drug aqueous solubility, food effects, high hepatic first-pass metabolism effects and short half-lives. Furthermore, the discovery and development of more effective psychotropic agents has stalled in recent times, with the majority of new drugs reaching the market offering similar efficacy, but suffering from the same oral delivery concerns. As such, the application of nanomedicine formulation approaches to currently available drugs is a viable option for optimizing oral drug delivery and maximizing treatment efficacy. This review focuses on the various delivery challenges encountered by psychotropic drugs, and the ability of nanomedicine formulation strategies to overcome these. Specifically, we critically review proof of concept in vitro and in vivo studies of nanoemulsions/microemulsions, solid lipid nanoparticles, dendrimers, polymeric micelles, nanoparticles of biodegradable polymers and nanosuspensions, and provide new insight into the various mechanisms for improved drug performance. The advantages and limitations of current oral nanomedicine approaches for psychotropic drugs are discussed, which will provide guidance for future research directions and assist in fostering the translation of such delivery systems to the clinical setting. Accordingly, emphasis has been placed on correlating the in vitro/in vivo performance of these nanomedicine approaches with their potential clinical outcomes and benefits for patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Post-fundoplication symptoms and complications: Diagnostic approach and treatment.

    Science.gov (United States)

    Sobrino-Cossío, S; Soto-Pérez, J C; Coss-Adame, E; Mateos-Pérez, G; Teramoto Matsubara, O; Tawil, J; Vallejo-Soto, M; Sáez-Ríos, A; Vargas-Romero, J A; Zárate-Guzmán, A M; Galvis-García, E S; Morales-Arámbula, M; Quiroz-Castro, O; Carrasco-Rojas, A; Remes-Troche, J M

    Laparoscopic Nissen fundoplication is currently considered the surgical treatment of choice for gastroesophageal reflux disease (GERD) and its long-term effectiveness is above 90%. Adequate patient selection and the experience of the surgeon are among the predictive factors of good clinical response. However, there can be new, persistent, and recurrent symptoms after the antireflux procedure in up to 30% of the cases. There are numerous causes, but in general, they are due to one or more anatomic abnormalities and esophageal and gastric function alterations. When there are persistent symptoms after the surgical procedure, the surgery should be described as "failed". In the case of a patient that initially manifests symptom control, but the symptoms then reappear, the term "dysfunction" could be used. When symptoms worsen, or when symptoms or clinical situations appear that did not exist before the surgery, this should be considered a "complication". Postoperative dysphagia and dyspeptic symptoms are very frequent and require an integrated approach to determine the best possible treatment. This review details the pathophysiologic aspects, diagnostic approach, and treatment of the symptoms and complications after fundoplication for the management of GERD. Copyright © 2016 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.

  15. Nutrient supplementation approaches in the treatment of ADHD.

    Science.gov (United States)

    Rucklidge, Julia J; Johnstone, Jeanette; Kaplan, Bonnie J

    2009-04-01

    Attention-deficit/hyperactivity disorder (ADHD) is a chronic, debilitating psychiatric illness that often co-occurs with other common psychiatric problems. Although empirical evidence supports pharmacological and behavioral treatments, side effects, concerns regarding safety and fears about long-term use all contribute to families searching for alternative methods of treating the symptoms of ADHD. This review presents the published evidence on supplementation, including single ingredients (e.g., minerals, vitamins, amino acids and essential fatty acids), botanicals and multi-ingredient formulas in the treatment of ADHD symptoms. In most cases, evidence is sparse, mixed and lacking information. Of those supplements where we found published studies, the evidence is best for zinc (two positive randomized, controlled trials); there is mixed evidence for carnitine, pycnogenol and essential fatty acids, and more research is needed before drawing conclusions about vitamins, magnesium, iron, SAM-e, tryptophan and Ginkgo biloba with ginseng. To date, there is no evidence to support the use of St John's wort, tyrosine or phenylalanine in the treatment of ADHD symptoms. Multi-ingredient approaches are an intriguing yet under-researched area; we discuss the benefits of this approach considering the heterogeneous nature of ADHD.

  16. The Secondary Organic Aerosol Processor (SOAP v1.0) model: a unified model with different ranges of complexity based on the molecular surrogate approach

    Science.gov (United States)

    Couvidat, F.; Sartelet, K.

    2015-04-01

    In this paper the Secondary Organic Aerosol Processor (SOAP v1.0) model is presented. This model determines the partitioning of organic compounds between the gas and particle phases. It is designed to be modular with different user options depending on the computation time and the complexity required by the user. This model is based on the molecular surrogate approach, in which each surrogate compound is associated with a molecular structure to estimate some properties and parameters (hygroscopicity, absorption into the aqueous phase of particles, activity coefficients and phase separation). Each surrogate can be hydrophilic (condenses only into the aqueous phase of particles), hydrophobic (condenses only into the organic phases of particles) or both (condenses into both the aqueous and the organic phases of particles). Activity coefficients are computed with the UNIFAC (UNIversal Functional group Activity Coefficient; Fredenslund et al., 1975) thermodynamic model for short-range interactions and with the Aerosol Inorganic-Organic Mixtures Functional groups Activity Coefficients (AIOMFAC) parameterization for medium- and long-range interactions between electrolytes and organic compounds. Phase separation is determined by Gibbs energy minimization. The user can choose between an equilibrium representation and a dynamic representation of organic aerosols (OAs). In the equilibrium representation, compounds in the particle phase are assumed to be at equilibrium with the gas phase. However, recent studies show that the organic aerosol is not at equilibrium with the gas phase because the organic phases could be semi-solid (very viscous liquid phase). The condensation-evaporation of organic compounds could then be limited by the diffusion in the organic phases due to the high viscosity. An implicit dynamic representation of secondary organic aerosols (SOAs) is available in SOAP with OAs divided into layers, the first layer being at the center of the particle (slowly

  17. TOBACCO SMOKING AND LUNG DISEASES: EFFICIENCY OF TREATMENT APPROACHES

    Directory of Open Access Journals (Sweden)

    V. A. Nikitin

    2016-01-01

    Full Text Available The review presents data on the significant increase of tobacco smoking prevalence and its harmful effect on the development and course of chronic respiratory diseases: tuberculosis, pneumonia, lung cancer, chronic obstructive pulmonary disease and asthma. Negative consequences of tobacco smoking are caused by chronic intoxication of the host by the components of tobacco smoke providing impact on various organs and cells of the host, thus causing a big variety of diseases. Both active and passive smoking deteriorates their course and increase the risk of exacerbation, hinders taking control over the disease and interferes with adequate response to drugs.Current approaches to treatment of tobacco addiction have been presented. There are several ways to overcome nicotine addiction – drug therapy and the other forms of therapy. Integrated approach to tobacco smoking management allows achieving success in 30% of cases within short period of time with continuous and quality remissions. 

  18. Metal chaperones: a holistic approach to the treatment of AD

    Directory of Open Access Journals (Sweden)

    Paul Anthony Adlard

    2012-03-01

    Full Text Available As the burden of proof for the role of metal ion dysregulation in the pathogenesis of multiple CNS disorders grows, it has become important to more precisely identify and differentiate the biological effects of various pharmacological modulators of metal ion homeostasis. This is particularly evident in disorders such as Alzheimer’s disease, where the use of metal chaperones (that transport metals, as opposed to chelators (which exclude metals from biological interactions, may prove to be the first truly disease modifying approach for this condition. The purpose of this mini-review is to highlight the emerging notion that metal chaperones, such as PBT2 (Prana Biotechnology, modulate a variety of critical pathways affecting key aspects of the AD cascade to provide a more holistic approach to the treatment of this disease.

  19. Nalmefene: a new approach to the treatment of alcohol dependence

    Directory of Open Access Journals (Sweden)

    Paille F

    2014-08-01

    Full Text Available François Paille, Hervé Martini Department of Addiction Treatment, University Hospital, Vandœuvre-lès-Nancy, France Abstract: Reduction of alcohol consumption is not yet a widely accepted treatment objective for alcohol-dependent patients, as abstinence is often considered to be the only possible objective in this situation. However, various studies have demonstrated the value of proposing these two options to such patients. Firstly, reduction of alcohol consumption very significantly reduces the risk of alcohol-related damage, and also modifies the patient's and the doctor's perception of the disease, resulting in improved access to care and better patient adherence with the proposed treatment objective and consequently better clinical results. Recent studies have shown that some medicinal products can help patients reduce their alcohol consumption. One such product, nalmefene, has been granted European marketing authorization and is now being released onto the market in various countries. The ESENSE 1 and 2 studies in alcohol-dependent patients showed that, in combination with BRENDA, a psychosocial intervention focusing on reinforcement of motivation and treatment adherence, nalmefene significantly reduced the number of heavy drinking days and mean daily total alcohol consumption versus placebo. This reduction was more marked in the marketing authorization target population, ie, patients with a high or very high drinking risk level according to World Health Organization criteria. Another original feature of this molecule is that it can be used as needed if the patient perceives a risk of drinking, which is a more flexible approach and more likely to ensure the patient's active involvement in the treatment of his/her disease. This molecule opens up interesting and original therapeutic prospects in the treatment of alcohol dependence. Keywords: alcohol dependence, reduction, consumption, damage reduction, drug therapy, nalmefene

  20. Insomnia in the elderly: cause, approach, and treatment.

    Science.gov (United States)

    Kamel, Nabil S; Gammack, Julie K

    2006-06-01

    Insomnia is a prevalent problem in late life. Sleep problems in the elderly are often mistakenly considered a normal part of aging. Insomnia, the most common sleep disorder, is a subjective report of insufficient or nonrestorative sleep despite adequate opportunity to sleep. Despite the fact that more than 50% of elderly people have insomnia, it is typically undertreated, and nonpharmacologic interventions are underused by health care practitioners. This article will review the causes of insomnia in the elderly, the approach to patient evaluation, and the nonpharmacologic and pharmacologic treatment of insomnia.

  1. Treatment Approaches to Urinary Stones Caused by Forgotten DJ Stents

    Directory of Open Access Journals (Sweden)

    Ergun Alma

    2015-03-01

    Full Text Available Ureteral DJ stents have been used widely for years in urology practice. With increased use, complications have been increased and forgotton stents have started to cause problems. The most common complications are early pain and irritative symptoms. Late complications are bacterial colonization and stone formation because of the biofilm covering the stents. Treatment for a forgotten stent varies on many factors, such as stent localization and stone formation. In this article, we aimed to discuss our clinic approach on two different cases in light to current literature. [Cukurova Med J 2015; 40(Suppl 1: 58-63

  2. Novel Approaches to the Treatment of Cancer in London UK

    Directory of Open Access Journals (Sweden)

    Judith Black

    2015-03-01

    Full Text Available An intensive and in-depth two-day conference providing an advanced level updateKEY TOPICS TO BE COVERED:New paradigms for targeted therapiesNew anti-cancer agents ~ industry viewpointNovel approaches to the treatment of breast cancer, melanoma and pancreatic cancerDrug development and precision radiotherapyEuropean drug development initiativesMarket access to novel cancer drugsRegulatory issues in marketing authorisation of anti-cancer productsGene and cell therapies and trial endpointsDeveloping cancer vaccinesCLICK HERE for more information 

  3. Non-pharmachological approaches to the treatment of chronic insomnia

    Directory of Open Access Journals (Sweden)

    Vita Štukovnik

    2013-05-01

    Full Text Available Sleep disorders have a negative impact on the quality of life and contribute to physical and mental health problems. Insomnia is a pervasive condition with various causes, manifestations, and health consequences. Even though it can be triggered by a variety of precipitating events, psychological and behavioral factors are almost always involved in perpetuating or exacerbating it over time, and lead to chronic condition. This article reviews some basic models and mechanisms of chronic insomnia as well as the rationale and objectives of cognitive-behavioral therapy (CBT in its management. CBT is a safe and effective treatment that may be used either as a monotherapy or to augment therapy with drugs. Evidence from controlled clinical trials indicates that the majority of patients (70 % to 80 % with persistent insomnia respond to this treatment, which is comparable to medication treatment. Aside from the clinically measurable changes, this therapy system enables patients to regain a feeling of control over their sleep, thereby reducing the emotional distress that sleep disorders cause. But despite the evidence for effectiveness and efficacy of these therapies and also the preference for non-pharmacological treatments expressed by many patients, psychological and behavioral approaches still remain underutilized by health care practitioners. Thus, an important challenge for the future is to disseminate these evidence-based therapies more effectively and increase their routine use in clinical practice.

  4. An algorithmic approach for the treatment of severe uncontrolled asthma

    Science.gov (United States)

    Zervas, Eleftherios; Samitas, Konstantinos; Papaioannou, Andriana I.; Bakakos, Petros; Loukides, Stelios; Gaga, Mina

    2018-01-01

    A small subgroup of patients with asthma suffers from severe disease that is either partially controlled or uncontrolled despite intensive, guideline-based treatment. These patients have significantly impaired quality of life and although they constitute asthma patients, they are responsible for more than half of asthma-related healthcare costs. Here, we review a definition for severe asthma and present all therapeutic options currently available for these severe asthma patients. Moreover, we suggest a specific algorithmic treatment approach for the management of severe, difficult-to-treat asthma based on specific phenotype characteristics and biomarkers. The diagnosis and management of severe asthma requires specialised experience, time and effort to comprehend the needs and expectations of each individual patient and incorporate those as well as his/her specific phenotype characteristics into the management planning. Although some new treatment options are currently available for these patients, there is still a need for further research into severe asthma and yet more treatment options. PMID:29531957

  5. Alcoholism and its treatment approach from a citizen perspective.

    Science.gov (United States)

    Gual, Antoni; Arbesú, José Ángel; Zarco, José; López Pelayo, Hugo; Miquel, Laia; Bobes, Julio

    2016-06-14

    The main objective of the study is to describe alcohol consumption in the general Spanish population, to discover citizens' opinion on their alcohol consumption, on alcoholism and on treatment approaches.   In 2015 a cross-sectional study was carried out by means of a telephone survey. A representative sample was selected. Participants were asked about their alcohol consumption, their perception of risk regarding their pattern of alcohol consumption, about their opinion on alcoholism, alcohol consequences and the treatment approach. A questionnaire was designed. The Alcohol Use Disorders Identification Test-C was used to define the pattern of alcohol intake. A descriptive and an statistical inference analysis were done. 22.1% were classified as risky drinkers, with a higher proportion in young males. The majority of individuals think that alcoholism is an illness, and more than 75% agree that alcohol has negative consequences on health, social functioning, occupational functioning and family relationships. Furthermore, the perception of risk that citizens have regarding their own drinking pattern is high (37.6%). 67.7% considered that the general practitioner can manage alcoholism, with females and older people believing this most strongly. Alcohol consumption is very prevalent in the Spanish population, especially in young people (31.8%). The perception of alcohol risk is high. The majority agree with the fact that general practitioners are well prepared for treating alcohol problems.

  6. [SURGICAL HIP DISLOCATION APPROACH FOR TREATMENT OF FEMORAL HEAD FRACTURE].

    Science.gov (United States)

    Tang, Yanfeng; Liu, Youwen; Zhu, Yingjie; Li, Jianming; Li, Wuyin; Li, Qiyi; Jia, Yudong

    2015-11-01

    To discuss the value of surgical hip dislocation approach in the treatment of femoral head fracture. A retrospectively analysis was made on the clinical data of 15 patients with femoral head fractures treated through surgical hip dislocation approach between January 2010 and February 2013. There were 11 men and 4 women with an average age of 30.8 years (range, 15-63 years). The causes included traffic accident injury in 9 cases, falling injury from height in 5 cases, and sports injury in 1 case. According to Pipkin typing, 2 cases were rated as type I, 7 cases as type II, 1 case as type III, and 5 cases as type IV. The interval of injury and operation was 2-10 days (mean, 4.1 days). Reduction was performed in 10 patients within 6 hours after injury, and then bone traction was given for 4-6 weeks except 5 patients who received reduction in the other hospital. Primary healing of incision was obtained in all patients after surgery without complications of dislocation and lower limbs deep venous thrombosis. The mean follow-up time was 29.9 months (range, 25-36 months). During follow-up, there was no infection, breakage of internal fixation, or nonunion of femoral greater trochanter fracture. In 3 patients having necrosis of the femoral head, 2 had no obvious symptoms [staging as IIa and IIb respectively according to Association Research Circulation Osseous (ARCO) staging system], and 1 (stage IIIb) had nonunion of the femoral neck fracture, who underwent total hip arthroplasty (THA). In 4 patients having myositis ossificans (2 cases of grade I, 1 case of grade II, and 1 case of grade III based on Brooker grading), no treatment was given in 3 cases and the focus was removed during THA in 1 case. According to the Thompson-Epstein scale at last follow-up, the results were excellent in 9 cases, good in 3 cases, fair in 1 case, and poor in 2 cases, and the excellent and good rate was 80%. Surgical hip dislocation approach can not only protect the residual vessels of the

  7. Novel approaches to diagnosis and treatment of Juvenile Myelomonocytic Leukemia.

    Science.gov (United States)

    Locatelli, Franco; Algeri, Mattia; Merli, Pietro; Strocchio, Luisa

    2018-02-01

    Juvenile myelomonocytic leukemia (JMML) is a clonal hematopoietic disorder of infancy/early childhood, resulting from oncogenic mutations in genes involved in the Ras pathway. As JMML often exhibits an aggressive course, the timing of diagnosis and treatment is critical to outcome. Areas covered: This review summarizes current approaches to diagnosis and treatment of JMML, highlighting most recent insights into genetic and epigenetic mechanisms underlying the disease, and providing an overview of novel potential therapeutic strategies. Expert commentary: At present, allogeneic HSCT remains the only potentially effective therapy, being able to cure more than 50% of patients, relapse representing the main cause of treatment failure. Prompt HSCT is recommended for all children with NF1, somatic PTPN11 and KRAS mutations, and for most children with somatic NRAS mutations. Conversely, a 'watch and wait' strategy should be adopted in children with germline CBL mutations, specific somatic NRAS mutation, and in Noonan syndrome patients, since spontaneous resolution has been reported to occur. Novel drugs targeting relevant nodes of JMML leukemogenesis have been explored in pre-HSCT window or at relapse. The use of 5-azacytidine, a DNA-hypomethylating agent reported to induce hematologic and molecular remission in some JMML children, is currently being investigated in clinical trials.

  8. Acne Scar Treatment: A Multimodality Approach Tailored to Scar Type.

    Science.gov (United States)

    Zaleski-Larsen, Lisa A; Fabi, Sabrina G; McGraw, Timothy; Taylor, Mark

    2016-05-01

    Acne scarring can be classified into atrophic icepick, boxcar, and rolling scars in addition to keloidal and hypertrophic scars. Additionally, these scars can be erythematous, hyperpigmented, and/or hypopigmented. Each scar type has a different structural cause warranting a customized approach. Many cosmetic options exist to address these changes individually, but little literature exists about the safety and efficacy of combining such procedures and devices. A Medline search was performed on combination treatments because it relates to facial acne scarring, and results are summarized. Practical applications for these combinations of procedures are also discussed. Studies examining the efficacy and safety of ablative, nonablative, fractionated, and nonfractionated lasers, dermabrasion, chemical peels, needling, subcision, radiofrequency, stem cell therapy, fat transplantation, platelet-rich plasma, and hyaluronic acid dermal fillers for acne scars were found. The authors review their experience in combining these techniques. Review of the literature revealed multiple single options for facial acne scarring treatment with minimal evidence in the literature found on the safety and efficacy of combining such procedures and devices. The authors' experience is that combining acne scar treatment techniques can be performed safely and synergistically with optimal patient outcomes.

  9. Current approach to the treatment of chronic myeloid leukaemia.

    Science.gov (United States)

    Pasic, Ivan; Lipton, Jeffrey H

    2017-04-01

    Of all the cancers, chronic myeloid leukaemia (CML) has witnessed the most rapid evolution of the therapeutic milieu in recent decades. The introduction of tyrosine kinase inhibitors (TKIs) as a therapeutic option has profoundly changed patient experience and outcome. The availability of multiple new highly effective therapies has increasingly underscored the importance of a good understanding of the underlying pathophysiological basis in CML, as well as patient-specific factors in choosing the right treatment for every individual. The treatment of CML has migrated in many jurisdictions from the office of a highly specialized malignant hematologist to the general hematologist or even a general practitioner. The goal of this review is to offer an overview of the modern approach to the treatment of CML, with an emphasis on chronic phase (CP) CML, including both TKI-based therapies such as imatinib, dasatinib, nilotinib, bosutinib and ponatinib, and non-TKI medications, such as omacetaxine. We discuss evidence behind each drug, most common and material adverse reactions and outline how this information can be used in selecting the right drug for the right patient. We also discuss evidence as it relates to other therapies, including stem cell transplant (SCT), and patients in accelerated (AP) and blastic phase (BP). Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Unifying hydrotropy under Gibbs phase rule.

    Science.gov (United States)

    Shimizu, Seishi; Matubayasi, Nobuyuki

    2017-09-13

    The task of elucidating the mechanism of solubility enhancement using hydrotropes has been hampered by the wide variety of phase behaviour that hydrotropes can exhibit, encompassing near-ideal aqueous solution, self-association, micelle formation, and micro-emulsions. Instead of taking a field guide or encyclopedic approach to classify hydrotropes into different molecular classes, we take a rational approach aiming at constructing a unified theory of hydrotropy based upon the first principles of statistical thermodynamics. Achieving this aim can be facilitated by the two key concepts: (1) the Gibbs phase rule as the basis of classifying the hydrotropes in terms of the degrees of freedom and the number of variables to modulate the solvation free energy; (2) the Kirkwood-Buff integrals to quantify the interactions between the species and their relative contributions to the process of solubilization. We demonstrate that the application of the two key concepts can in principle be used to distinguish the different molecular scenarios at work under apparently similar solubility curves observed from experiments. In addition, a generalization of our previous approach to solutes beyond dilution reveals the unified mechanism of hydrotropy, driven by a strong solute-hydrotrope interaction which overcomes the apparent per-hydrotrope inefficiency due to hydrotrope self-clustering.

  11. Towards a Unified Sentiment Lexicon Based on Graphics Processing Units

    Directory of Open Access Journals (Sweden)

    Liliana Ibeth Barbosa-Santillán

    2014-01-01

    Full Text Available This paper presents an approach to create what we have called a Unified Sentiment Lexicon (USL. This approach aims at aligning, unifying, and expanding the set of sentiment lexicons which are available on the web in order to increase their robustness of coverage. One problem related to the task of the automatic unification of different scores of sentiment lexicons is that there are multiple lexical entries for which the classification of positive, negative, or neutral {P,N,Z} depends on the unit of measurement used in the annotation methodology of the source sentiment lexicon. Our USL approach computes the unified strength of polarity of each lexical entry based on the Pearson correlation coefficient which measures how correlated lexical entries are with a value between 1 and −1, where 1 indicates that the lexical entries are perfectly correlated, 0 indicates no correlation, and −1 means they are perfectly inversely correlated and so is the UnifiedMetrics procedure for CPU and GPU, respectively. Another problem is the high processing time required for computing all the lexical entries in the unification task. Thus, the USL approach computes a subset of lexical entries in each of the 1344 GPU cores and uses parallel processing in order to unify 155802 lexical entries. The results of the analysis conducted using the USL approach show that the USL has 95.430 lexical entries, out of which there are 35.201 considered to be positive, 22.029 negative, and 38.200 neutral. Finally, the runtime was 10 minutes for 95.430 lexical entries; this allows a reduction of the time computing for the UnifiedMetrics by 3 times.

  12. [Leukotriene antagonists: a new approach in the treatment of asthma].

    Science.gov (United States)

    Devillier, P; Bessard, G; Advenier, C

    1997-06-01

    Inflammation plays an essential role in the genesis of airflow obstruction and bronchial hyper-reactivity in the early stages of clinical asthma. The treatment of bronchial inflammation has become an essential element in the therapeutic strategy and principally rests on inhaled glucocorticoids. Amongst a number of inflammatory mediators leukotrienes occupy a privileged place by the power of their inflammatory and constrictor effects on bronchial smooth muscles. These properties have justified the clinical development of inhibitors of their synthesis and of specific antagonists to their receptors. Leukotriene antagonists are specific for a sub type of leukotriene receptors C4, D4 and E4 which is implicated in the majority of the bronchial constrictor and inflammatory effects of leukotrienes. The antagonists of Cys-LT1 receptor but also the inhibitors of the leukotriene synthesis exert an additive bronchodilator effect to those of B2 stimulants confirming an efficacious protection vis a vis bronchial provocation tests and above all they improve the clinical scores, lung function and also enable a decrease in the consumption of beta 2 agonists. The marketing of these products represents a major event because it corresponds to the advent of a new therapeutic class. The ease of administration by the oral route, their demonstrated efficacy and their good tolerance profile (in particular for ICI 204.219, and antagonists to Cys-LT1 receptors) are elements which foresee a success for this new asthmatic treatment. However numerous studies, notably comparative studies vis a vis reference treatments will be necessary to define their place in the strategic approach to the treatment of asthma.

  13. Experimental status of unified theories

    International Nuclear Information System (INIS)

    Bilen'kij, S.M.

    1979-01-01

    A standard SU(2)xU(1) theory is discussed. It is based on an assumption that the left components of fields form doublets, and the rignt ones - singlets. From the weak interaction lagrangian an expression is obtained for the effective hamiltonian describing neutrino-lepton processes. The results of discussing the experimental status of the unified theories of weak and electromagnetic interactions are in agreement with the simplest version of the unified theories - the Weinberg-Salam theory. It has been noted that the accuracy of the experiments (not exceeding 20%) is insufficient and no information is available on diagonal terms of the hamiltonian

  14. The Simplest Unified Growth Theory

    DEFF Research Database (Denmark)

    Strulik, Holger; Weisdorf, Jacob Louis

    This paper provides a unified growth theory, i.e. a model that explains the very long-run economic and demographic development path of industrialized economies, stretching from the pre-industrial era to present-day and beyond. Making strict use of Malthus' (1798) so-called preventive check...... hypothesis - that fertility rates vary inversely with the price of food - the current study offers a new and straightforward explanation for the demographic transition and the break with the Malthusian era. The current framework lends support to existing unified growth theories and is well in tune...

  15. Treatment approaches and antibiotic use for emergency dental treatment in Turkey

    Directory of Open Access Journals (Sweden)

    Kaptan RF

    2013-11-01

    Full Text Available Rabia Figen Kaptan,1 Faruk Haznedaroglu,2 Fatima Betul Basturk,3 Mehmet Baybora Kayahan11Department of Endodontics, Yeditepe University, 2Department of Endodontics, Istanbul University, 3Department of Endodontics, Marmara University, Istanbul, TurkeyAbstract: The purpose of this study was to gather information about Turkish general dental practitioners' treatment approaches towards endodontic emergencies, antibiotic-prescribing habits, and their participation in lifelong learning programs. Questionnaires were given to dentists who attended the 16th National Congress organized by the Turkish Dental Association. From 1,400 questionnaires distributed, 589 (43% were deemed usable in this study. This survey dealt with questions that were subdivided into two main topics: dental emergency treatment approaches, and antibiotic prescription and information on lifelong learning program participation. The statistical analysis was conducted with a Χ2 test at a significance level of P<0.05. For irreversible pulpitis cases in vital teeth, most of the dental practitioners (65.3% preferred single-visit root canal treatments. For teeth presenting a periapical lesion, the preferred treatment approach was root canal treatment (91.5%. The rate of prescription of analgesics and antibiotics was 21.7% in untreated acute apical periodontitis cases and 41% in acute apical abscess cases. Frequently prescribed antibiotics were amoxicillin–clavulanate (61.8% and amoxicillin (46.5%. There was a tendency for practitioners to attend congresses as their years of professional practice increased (P<0.0001. There have been discrepancies between taught and observed practice. Educational initiatives are needed to prevent inappropriate prescription of antibiotics.Keywords: antibiotic prescription, endodontic emergency, survey, Turkey

  16. A Unified Approach to Abductive Inference

    Science.gov (United States)

    2014-09-30

    nEmesis: Which Restaurants Should You Avoid Today?, First AAAI Conference on Human Computation and Crowdsourcing (HCOMP). 07-NOV-13, . : , Young Chol...Relationships in Consumer Photo Collections using Markov Logic, 3rd International Workshop on Semantic Learning and Applications in Multimedia Applications...noisy and fragmentary observations of their behaviour . During the reporting period, we made significant progress on both applied and fundamental work

  17. A unified kinetic approach to binary nucleation

    Energy Technology Data Exchange (ETDEWEB)

    Kevrekidis, P.G. [Department of Physics, Rutgers University, 136 Frelinghuysen Road]|[E.O.H.S.I., Rutgers University]|[UMDNJ, 170 Frelinghuysen Road, Piscataway, New Jersey 08854-8019 (United States); Lazaridis, M. [Norwegian Institute for Air Research (NILU), Instittutvein 18, P. O. Box 100, N-2007 Kjeller (Norway); Drossinos, Y. [European Commission, Joint Research Centre, I-21020 Ispra (Vatican City State, Holy See) (Italy); Georgopoulos, P.G. [E.O.H.S.I., Rutgers University]|[UMDNJ, 170 Frelinghuysen Road, Piscataway, New Jersey 08854 (United States)

    1999-11-01

    Two different methods to calculate the steady-state nucleation rate in heteromolecular systems proposed by Stauffer (1976) and Langer (1969) are analyzed. Their mathematical equivalence is explicitly demonstrated, thereby obtaining a generic expression for the rate of binary nucleation. Its numerical evaluation does not entail rotation of the coordinate system at the saddle point, but it only requires data in the natural coordinate system of number fluctuations, namely molecular impingement rates, the droplet free energy and its second order derivatives at the saddle point, and the total density of condensible vapors. {copyright} {ital 1999 American Institute of Physics.}

  18. Orchestrating a unified approach to information management.

    Science.gov (United States)

    Friedman, B A

    1997-01-01

    Articles in both business and healthcare literature make frequent reference to the need for integration in healthcare organizations. In healthcare, the term horizontal integration can refer to the purchase of one hospital by another in the same geographical area, particularly where the hospitals' services overlap. Services might be consolidated in this example or one hospital may totally shut down the acquired one. Vertical integration refers to a hospital exercising control of its inputs or outputs. In one sense, patients referred to a hospital can be considered inputs. A hospital that purchases physician practices or integrated delivery systems is an example. Purchasing a nursing facility by an integrated delivery system (IDS) is another. This article focuses on organizational or holographic integration, where an organization is understood and embedded--like a hologram--in each of its smaller components, and each operating unit has knowledge about the whole system in which it is embedded. Conceptually, a hospital can achieve organizational integration relatively easily. One way is to assign administrative responsibility for two departments, radiology and pathology, for example, to one person who will handle billing, budgeting and human resources issues. Organizational integration breaks down turf barriers between distinct functional areas (often known as stovepipes or the silo mentality) because the result is less energy expended to solve problems. Organizational integration must include the merging of information technology (IT) into a single computer system that can report results across several departments, for example, in order entry, result reporting, resource scheduling or billing. At the University of Michigan Health System, technical and organizational integration are taking place across the information systems of the radiology and pathology departments. Deployment of an intranet-based architecture for ancillary information systems will provide the means to achieve high level integration across previously heterogeneous and non-integrated department-based clinical information systems.

  19. Unified approach to alpha decay calculations

    Indian Academy of Sciences (India)

    2014-05-02

    nucleus systems, is also being .... It can be seen from (7) that n is the number of nodes of WKB wave function between ..... It will be very interesting to have a systematic comparative study of these three ... C 80, 014314 (2009); Phys.

  20. New therapeutic approaches for treatment of tularaemia: a review

    Directory of Open Access Journals (Sweden)

    Sandrine eBOISSET

    2014-03-01

    Full Text Available Antibiotic treatment of tularaemia is based on a few drugs, including the fluoroquinolones, the tetracyclines and the aminoglycosides. Because no effective and safe vaccine is currently available, tularaemia prophylaxis following proven exposure to F. tularensis also relies on administration of antibiotics. A number of reasons make it necessary to search for new therapeutic alternatives: the potential toxicity of first-line drugs, especially in children and pregnant women; a high rate of treatment relapses and failures, especially for severe and/or suppurated forms of the disease; and the possible use of antibiotic-resistant strains in the context of a biological threat. This review presents novel therapeutic approaches that have been explored in recent years to improve tularaemia patients’ management and prognosis. First, the activities of newly available antibiotic compounds were evaluated against F. tularensis, including tigecycline (a glycylcycline, ketolides (telithromycin and cethromycin and fluoroquinolones (moxifloxacin, gatifloxacin, trovafloxacin and grepafloxacin. The liposome delivery of some antibiotics was evaluated. The effect of antimicrobial peptides against F. tularensis was also considered. Other drugs were evaluated for their ability to suppress the intracellular multiplication of F. tularensis. The effects of the modulation of the innate immune response (especially via TLR receptors on the course of F. tularensis infection were characterized. Another approach was the administration of specific antibodies to induce passive resistance to F. tularensis infection. All of these studies highlight the need to develop new therapeutic strategies to improve the management of patients with tularaemia. Many possibilities exist, some unexplored. Moreover, it is likely that new therapeutic alternatives that are effective against this intracellular pathogen could be, at least partially, extrapolated to other human pathogens.

  1. Treatment approaches for interoceptive dysfunctions in drug addiction.

    Science.gov (United States)

    Paulus, Martin P; Stewart, Jennifer L; Haase, Lori

    2013-10-18

    There is emerging evidence that individuals with drug addiction have dysfunctions in brain systems that are important for interoceptive processing, which include, among others, the insular and the anterior cingulate cortices. These individuals may not be expending sufficient neural resources to process perturbations of the interoceptive state but may exert over-activation of these systems when processing drug-related stimuli. As a consequence, insufficient detection and processing of interoceptive state changes may result in inadequate anticipation and preparation to adapt to environmental challenges, e.g., adapt to abstinence in the presence of withdrawal symptoms. Here, we integrate interoceptive dysfunction in drug-addicted individuals, with the neural basis for meditation and exercise to develop a heuristic to target the interoceptive system as potential treatments for drug addiction. First, it is suggested that mindfulness-based approaches can modulate both interoceptive function and insular activation patterns. Second, there is an emerging literature showing that the regulation of physical exercise in the brain involves the insula and anterior cingulate cortex and that intense physical exercise is associated with a insula changes that may provide a window to attenuate the increased interoceptive response to drug-related stimuli. It is concluded that the conceptual framework of interoceptive dysfunctions in drug addiction and the experimental findings in meditation and exercise provide a useful approach to develop new interventions for drug addiction.

  2. Treatment of cyanide containing wastewater using cavitation based approach.

    Science.gov (United States)

    Jawale, Rajashree H; Gogate, Parag R; Pandit, Aniruddha B

    2014-07-01

    Industrial wastewater streams containing high concentrations of biorefractory materials like cyanides should ideally be treated at source. In the present work, degradation of potassium ferrocyanide (K4Fe(CN)6) as a model pollutant has been investigated using cavitational reactors with possible intensification studies using different approaches. Effect of different operating parameters such as initial concentration, temperature and pH on the extent of degradation using acoustic cavitation has been investigated. For the case of hydrodynamic cavitation, flow characteristics of cavitating device (venturi) have been established initially followed by the effect of inlet pressure and pH on the extent of degradation. Under the optimized set of operating parameters, the addition of hydrogen peroxide (ratio of K4Fe(CN)6:H2O2 varied from 1:1 to 1:30 mol basis) as process intensifying approach has been investigated. The present work has conclusively established that under the set of optimized operating parameters, cavitation can be effectively used for degradation of potassium ferrocyanide. The comparative study of hydrodynamic cavitation and acoustic cavitation suggested that hydrodynamic cavitation is more energy efficient and gives higher degradation as compared to acoustic cavitation for equivalent power/energy dissipation. The present work is the first one to report comparison of cavitation based treatment schemes for degradation of cyanide containing wastewaters. Copyright © 2014 Elsevier B.V. All rights reserved.

  3. [Supra-aortic trunks occlusive disease: three different treatment approaches].

    Science.gov (United States)

    Dias, P; Almeida, P; Sampaio, S; Silva, A; Leite-Moreira, A; Pinho, P; Roncon de Albuquerque, R

    2010-01-01

    Unlike carotid bifurcation atherosclerotic stenosis, supra-aortic trunks (SAT) occlusive disease is rare and its revascularization uncommon, accouting for less than 10% of the operations performed on the extracranial brain-irrigating arteries. There are three different treatment approaches: transthoracic, extra-anatomic cervical and endovascular. Endovascular repair is gaining popularity as first-line therapy for proximal lesions with favorable anatomy because of its low morbidity and rare mortality. Extra-anatomic bypass is a safe and durable reconstruction and should be considered in patients with single vessel disease, with cardiopulmonary high-risk or with limited life expectancy. If cardiac surgery is needed, central transthoracic reconstruction is preferable, and the two procedures should be combined. The long-term patency of bypasses with aortic origin, specially when multiple vessels are involved, is superior to other repair techniques. We present three clinical cases that illustrate each of these therapeutic strategies: central brachiocephalic revascularization and synchronous cardiac surgery in a patient with complex SAT atherosclerosis disease; subclavian-carotid transposition for disabling upper limb claudication; and subclavian artery stenting for subclavian-steal syndrome. Surgical approach selection should be based on the individual patient's anatomy and operative risk.

  4. A Novel Approach for Pathogen Reduction in Wastewater Treatment

    Directory of Open Access Journals (Sweden)

    Dhevagi Periasamy

    2013-06-01

    Full Text Available Many sewage waste treatment systems are aiming for complete pathogen removal which necessitates search for novel approaches that does not harm the environment. One such novel approach is exploring the possibilities of bacteriophages for pathogen removal. Hospital wastewater was collected from different locations of Tamil Nadu and used for the study. The total heterotroph and total coliform population ranged from 1.6 × 105 to 8.3 × 106 per mL and from 1.2 × 103 to 1.6 × 103/ 100 mL of sample respectively. Higher frequency of antibiotic resistant E. coli, Pseudomonas sp. Streptococcus sp and Bacillus spp were observed in all the places, which clearly indicated the extent of pollution. All the samples had specific phages against E. coli and none of the samples had phages against MTCC culture. E. coli specific phage was isolated and the population of phage required for effective killing of E. coli has been standardized as 3 × 104 pfu / mL of lysate. The inoculation resulted in 100% removal of pathogen from sewage water within 14 hours of incubation.

  5. Treatment Approaches for Interoceptive Dysfunctions in Drug Addiction

    Directory of Open Access Journals (Sweden)

    Martin P Paulus

    2013-10-01

    Full Text Available There is emerging evidence that individuals with drug addiction have dysfunctions in brain systems that are important for interoceptive processing, which include, among others, the insular and the anterior cingulate cortices. These individuals may not be expending sufficient neural resources to process perturbations of the interoceptive state but may exert over-activation of these systems when processing drug-related stimuli. As a consequence, insufficient detection and processing of interoceptive state changes may result in inadequate anticipation and preparation to adapt to environmental challenges, e.g. adapt to abstinence in the presence of withdrawal symptoms. Here, we integrate interoceptive dysfunction in drug-addicted individuals, with the neural basis for meditation and exercise to develop a heuristic to target the interoceptive system as potential treatments for drug addiction. First, it is suggested that mindfulness-based approaches can modulate both interoceptive function and insular activation patterns. Second, there is an emerging literature that the regulation of physical exercise in the brain involves the insula and anterior cingulate cortex and that intense physical exercise is associated with a state-dependent activation difference in the insula that may provide a window to attenuate the increased interoceptive response drug related stimuli. It is concluded that the conceptual framework of interoceptive dysfunctions in drug addiction and the experimental findings in meditation and exercise provide a useful approach to develop new interventions for drug addiction.

  6. Integrated approach in the treatment of metabolic syndrome

    Directory of Open Access Journals (Sweden)

    2014-03-01

    Full Text Available The Goal of this study was to investigate the efficacy of the integrated approach for the treatment of metabolic syndrome (MS aiming to correct all of its components versus standard therapy using clinical outcomes (BMI, waist circumference, blood pressure, lipid levels, assessment of psychological status (Beck Depression Inventory, and quality of life (SF-36. Methods: A total of 60 patients with MS were included in the study. The study group (30 subjects mean age 41.0±11 years, women - 23 (76.7%, men - 7 (23.3% received the complex therapy of MS - pharmacotherapy of obesity (orlistat and insulin resistance (metformin, lipid-lowering therapy (statins or fibrates, antihypertensive therapy. Control group (30 patients mean age 43.4±9.5 years, women - 26 (86.7%, men - 4 (13.3% was treated with statins or fibrates and received antihypertensive therapy when needed. At the inclusion in the study and after 6 months of therapy all patients underwent clinical and laboratory investigation, assessment of depression and quality of life. Results: We found a more significant reduction of all clinical outcomes (body weight, blood pressure, improvement in glucose and lipid metabolism, a significant decrease in the prevalence and severity of the depression, and an improvement in the quality of life in patients of study group compared with standard therapy. Conclusion: Complex treatment of the MS, including pharmacotherapy of obesity (orlistat, Xenical and insulin resistance (metformin, Glucophage is characterized by a greater clinical efficacy compared with standard therapy.

  7. Polymer Therapeutics: Biomarkers and New Approaches for Personalized Cancer Treatment.

    Science.gov (United States)

    Atkinson, Stuart P; Andreu, Zoraida; Vicent, María J

    2018-01-23

    Polymer therapeutics (PTs) provides a potentially exciting approach for the treatment of many diseases by enhancing aqueous solubility and altering drug pharmacokinetics at both the whole organism and subcellular level leading to improved therapeutic outcomes. However, the failure of many polymer-drug conjugates in clinical trials suggests that we may need to stratify patients in order to match each patient to the right PT. In this concise review, we hope to assess potential PT-specific biomarkers for cancer treatment, with a focus on new studies, detection methods, new models and the opportunities this knowledge will bring for the development of novel PT-based anti-cancer strategies. We discuss the various "hurdles" that a given PT faces on its passage from the syringe to the tumor (and beyond), including the passage through the bloodstream, tumor targeting, tumor uptake and the intracellular release of the active agent. However, we also discuss other relevant concepts and new considerations in the field, which we hope will provide new insight into the possible applications of PT-related biomarkers.

  8. Minimally invasive approaches for the treatment of inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    Marco Zoccali; Alessandro Fichera

    2012-01-01

    Despite significant improvements in medical management of inflammatory bowel disease,many of these patients still require surgery at some point in the course of their disease.Their young age and poor general conditions,worsened by the aggressive medical treatments,make minimally invasive approaches particularly enticing to this patient population.However,the typical inflammatory changes that characterize these diseases have hindered wide diffusion of laparoscopy in this setting,currently mostly pursued in high-volume referral centers,despite accumulating evidences in the literature supporting the benefits of minimally invasive surgery.The largest body of evidence currently available for terminal ileal Crohn's disease shows improved short term outcomes after laparoscopic surgery,with prolonged operative times.For Crohn's colitis,high quality evidence supporting laparoscopic surgery is lacking.Encouraging preliminary results have been obtained with the adoption of laparoscopic restorative total proctocolectomy for the treatment of ulcerative colitis.A consensus about patients' selection and the need for staging has not been reached yet.Despite the lack of conclusive evidence,a wave of enthusiasm is pushing towards less invasive strategies,to further minimize surgical trauma,with single incision laparoscopic surgery being the most realistic future development.

  9. The Laparoscopic Approach in the Treatment of Diverticular Colon Disease

    Science.gov (United States)

    del Olmo, J. C. Martin; Blanco, J. I.; de la Cuesta, C.; Atienza, R.

    1998-01-01

    Background and Objectives: The experience with treatment of diverticular colon disease (DCD) by the laparoscopic method is analyzed. Methods: Between January 1994 and July 1997, a group of 22 patients with criteria for symptomatic diverticular disease in the descending and sigmoid colon underwent laparoscopy with average resections of 40 cm. Intra-abdominal mechanical anastomosis completed the procedure. Results: The operative morbidity was 28%. Two cases, in acute diverticulitis phase, were reconverted to open surgery, and three cases presented postoperative rectorrhagia which ceased spontaneously. No long-term complications have been found. Postoperative hospitalization was 4-8 days (mean 5.5) and mean operative time was 165 minutes (range 120-240). Conclusions: Nevertheless, the learning curve precise to practice this type of surgery, the acceptable morbity-mortality rates which the laparoscopic method presents, especially with these high-risk groups of patients (age > 65, high blood pressure, etc), encouraged us to modified the criteria indicating surgery for the disease, offering first choice operative treatment with efficiency and safety. However, we feel that those patients with acute complications of diverticular colon disease must be excluded initially for laparoscopic approach. PMID:9876730

  10. Selection of treatment and surgical approach for vestibular schwannomas

    International Nuclear Information System (INIS)

    Eguchi, Kuniki; Yamaguchi, Satoshi; Sakoda, Eiichiro

    2007-01-01

    Described are the present state of selection of stereotactic radiotherapy or surgical treatment and their combination for schwannomas in the title, and authors' policy of surgery as a first choice treatment. The policy stands on the concept that surgery is useful for the controllability thereafter of the tumor, of which size is at first larger than 25 mm diameter, and radiotherapy like a gamma-knife is applicable to the residual tissue grown after operation and to the tissue with less than the size before surgery because the smaller the size, the better is thought the control by the knife (reportedly 100% for the tissue of <14 mm diameter). The basis of authors' selection of two surgical approaches of through-lower lateral occiput and trans-labyrinthine, and their outcomes like hearing loss are described and discussed in details for 24 patients (two underwent radiotherapy before surgery) during the period Sep. 2003-Aug. 2006 of authors' hospital. Radiotherapy is thought essentially useful for the control of the tumor with a small or surgically reduced size. (R.T.)

  11. Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

    Directory of Open Access Journals (Sweden)

    Chien WT

    2013-09-01

    Full Text Available Wai Tong Chien, Annie LK Yip School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Abstract: During the last three decades, an increasing understanding of the etiology, psychopathology, and clinical manifestations of schizophrenia spectrum disorders, in addition to the introduction of second-generation antipsychotics, has optimized the potential for recovery from the illness. Continued development of various models of psychosocial intervention promotes the goal of schizophrenia treatment from one of symptom control and social adaptation to an optimal restoration of functioning and/or recovery. However, it is still questionable whether these new treatment approaches can address the patients' needs for treatment and services and contribute to better patient outcomes. This article provides an overview of different treatment approaches currently used in schizophrenia spectrum disorders to address complex health problems and a wide range of abnormalities and impairments resulting from the illness. There are different treatment strategies and targets for patients at different stages of the illness, ranging from prophylactic antipsychotics and cognitive–behavioral therapy in the premorbid stage to various psychosocial interventions in addition to antipsychotics for relapse prevention and rehabilitation in the later stages of the illness. The use of antipsychotics alone as the main treatment modality may be limited not only in being unable to tackle the frequently occurring negative symptoms and cognitive impairments but also in producing a wide variety of adverse effects to the body or organ functioning. Because of varied pharmacokinetics and treatment responsiveness across agents, the medication regimen should be determined on an individual basis to ensure an optimal effect in its long-term use. This review also highlights that the recent practice guidelines and standards have

  12. Toward a Unified Communication Theory.

    Science.gov (United States)

    McMillan, Saundra

    After discussing the nature of theory itself, the author explains her concept of the Unified Communication Theory, which rests on the assumption that there exists in all living structures a potential communication factor which is delimited by species and ontogeny. An organism develops "symbol fixation" at the level where its perceptual abilities…

  13. A model unified field equation

    International Nuclear Information System (INIS)

    Perring, J.K.; Skyrme, T.H.R.

    1994-01-01

    The classical solutions of a unified field theory in a two-dimensional space-time are considered. This system, a model of a interacting mesons and baryons, illustrates how the particle can be built from a wave-packet of mesons and how reciprocally the meson appears as a tightly bound combination of particle and antiparticle. (author). 6 refs

  14. Rationales and treatment approaches underpinning the use of acupuncture and related techniques for plantar heel pain: a critical interpretive synthesis.

    Science.gov (United States)

    Clark, Maria T; Clark, Richard J; Toohey, Shane; Bradbury-Jones, Caroline

    2017-03-01

    Acupuncture shows promise as a treatment for plantar heel pain (PHP) or plantar fasciitis (PF), but data heterogeneity has undermined demonstration of efficacy. Recognising that acupuncture is a diverse field of practice, the aim of this study was to gain a broader, global perspective on the different approaches and rationales used in the application of acupuncture in PHP. We built upon an earlier systematic review (which was limited by the necessity of a methodological focus on efficacy) using the critical interpretive synthesis (CIS) method to draw upon a wider international sample of 25 clinical sources, including case reports and case series. Multiple tracks of analysis led to an emergent synthesis. Findings are presented at three levels: primary (summarised data); secondary (patterns observed); and tertiary (emergent synthesis). Multiple treatments and rationales were documented but no single approach dominated. Notable contradictions emerged such as the application of moxibustion by some authors and ice by others. Synthesis of findings revealed a 'patchwork' of factors influencing the approaches taken. The complexity of the field of acupuncture was illustrated through the 'lens' of PHP. The 'patchwork' metaphor provides a unifying framework for a previously divergent community of practice and research. Several directions for future research were identified, such as: importance of prior duration; existence of diagnostic subgroups; and how practitioners make clinical decisions and report their findings. CIS was found to provide visibility for multiple viewpoints in developing theory and modelling the processes of 'real world' practice by acupuncturists addressing the problem of PHP. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  15. Cincinnati's Bold New Venture: A Unified K-12 Reading/Communication Arts Program.

    Science.gov (United States)

    Green, Reginald Leon

    1989-01-01

    Describes a unified reading/communication arts program in the Cincinnati Public School System which uses new basal texts, support materials, and a customized instructional system for each grade level, integrating listening, speaking, reading, writing, and thinking skills into a unified language approach. Discusses intervention strategies,…

  16. The Multidisciplinary Conservative Approach in Treatment of TOS

    Directory of Open Access Journals (Sweden)

    F. Layeghi

    2010-10-01

    Full Text Available Objectives: The aims of this study were to evaluate the efficacy of conservative treatment in patients with and without cervical ribs and Thoracic Outlet Syndrome (TOS. From so many kinds of conservative treatment in literature, we used a multidisciplinary approach (correction of posture, maximizing muscle endurance and power, stretch shorten muscles, massage for trigger points and maximize thoracic span with stomach breathing to get more effective treatment and a longer time of relief with less duration and more long-term relief. Methods: Twenty six female patients with or without cervical ribs, pain and numbness were included in this study. They were assessed in terms of posture, muscle testing and shortness in muscles in all part of the body. Initial pain status were recorded and after eight weeks treatment including posture correction, their pain were assessed again with visual analogue scale that 0 was no pain and 10 was intolerable pain. Results: In 100 % of patients initial pain score were more than 5 in visual analogue scale. 23.1% of cases showed reduced pain scores to lower than 5 scales. Age was not a significant factor (P=0.93 on pain reducing. Type of posture was independent from pain and pain diminishing (0.004. Cervical rib was effective in initial pain (P=0.08 and degree of diminishing pain (P=0.236. Initial pain of 57.1% of patients with cervical rib was 10 due to visual analogue scale (VAS. In 33.3% of the persons with bilateral cervical rib we saw more than 5 degree in diminishing pain. In the 85.7% patients with unilateral cervical rib, we had more than 5 degree diminishing pain and we saw this in all of the non cervical rib TOS. Dicussion: Faulty posture can cause narrowing of the thoracic outlet space and may lead to pain and numbness, and some other symptoms. Correction of posture despite of cervical rib can widen the space and reduces pressure on vessels and nerves. Postural correction and long time follow up must be

  17. A unifying theory The universe on a string

    CERN Multimedia

    Greene, Brian

    2006-01-01

    Seventy-five years ago, Albert Einstein completed his unified field theory; but, as had happened before and would happen again, Einstein had to go bak to the drawing board. Much progress have been inspired, with the most recent advances coming from an approach called string theory. (1,5 page)

  18. Novel electrophysiological approaches to clinical epilepsy. Diagnosis and treatment

    International Nuclear Information System (INIS)

    Kanazawa, Kyoko; Matsumoto, Riki; Ikeda, Akio; Kinoshita, Masako

    2011-01-01

    Seizure onset zone (SOZ) is currently defined by ictal epileptiform discharges, which are most commonly recorded as regional low-voltage fast waves or repetitive spikes. Interictal epileptiform discharges, on the other hand, are not specific enough for SOZ as they are recorded at zones other than the SOZ; they are also recorded from areas that do not generate the ictal pattern and from areas to which ictal discharges propagate. Besides spikes and sharp waves, a novel index of human epileptogenicity has been investigated in association with wide-band electroencephalography (EEG) analysis. We primarily noted the following during clinical neurophysiological analysis for clinical epilepsy. Recent development of digital EEG technology enabled us to record wide-band EEG in a clinical setting. Thus, high frequency (>200 Hz) and low frequency (<1 Hz) components can be reliably recorded using subdural electrodes. Direct current shift, slow shift, ripple, and fast ripple can be well delineated, and they will be potentially useful in the diagnosis and management of epileptic patients. Fiber tractography (morphological parameter) and cortico-cortical-evoked potentials with single cortical stimulation (electrophysiological parameter) elucidated cortico-cortical connections in human brain. The data thus obtained can help us understand the mechanism of seizure propagation and normal cortical functional connectivity. Non-invasive simultaneous recording of EEG and functional magnetic resonance imaging (fMRI) provided information on the roles of deep brain structures associated with scalp-recorded epileptiform discharges. Interventional neurophysiology can shed light on the non-pharmacological treatment of epilepsy. In this report, we discuss these novel electrophysiological approaches to the diagnosis and treatment of clinical epilepsy. (author)

  19. A novel Antibody based approach to Cancer Treatment

    Directory of Open Access Journals (Sweden)

    Yoshikazu Kurosawa

    2010-01-01

    Full Text Available Cancer is one of the leading causes of death among the human race. No valid modalities of treatment other than surgical treatment have been established for this disease. We aimed to identify and to characterize cancer using large number of human monoclonal antibodies (mAbs which are specific against their surface for new molecular targeted immunotherapy. In order to find proper targets for therapeutic antibodies against cancers we developed a screening strategy. We used a huge phage library of human antibodies. At the first step we comprehensively isolated many monoclonal antibodies (mAbs that specifically bound to surface of cancer cells. Development of ICOS (Isolation of antigen/antibody complexes through organic solvent method allowed us to succeed in isolation of a huge number of mAbs with various characteristics (Y Akahori et al. 2009. At the next step we selected clones that showed tumor-specific staining patterns in immunohistochemical (IHC analysis by using many fresh cancer tissues reseted. Many surgeons took part in this project. Finally the antigens recognized by these clones were identified by immunoprecipitation (IP followed by analysis with mass (MS spectrometry (G Kurosawa et al. 2009. We have succeeded in identification of 29 tumor-associated antigens (TAAs and in isolation of 441 human mAbs that specifically bound to one of the 29 TAAs (G Kurosawa et al. 2008. In these screenings of the library, rounds of the selection process, mixing of cells and phage particles centrifugation growth of phages, were repeated three to four times in each screening. Therefore, numbers of phages of the clones whose antigens were abundantly present on the cell surface increased during the screenings. Recently we developed a new method for isolation of clones whose antigens were less abundantly present on the cell surface. Hence, we would like to talk on these methodology and discuss regarding this “A novel antibody based approach to Cancer

  20. A unified treatment of high energy interactions

    International Nuclear Information System (INIS)

    Drescher, H.J.; Werner, K.; Ostapchenko, S.; Centre National de la Recherche Scientifique, 44 - Nantes

    1999-01-01

    It is well known that high energy interactions as different as electron-positron annihilation, deep inelastic lepton-nucleon scattering, proton-proton interactions, and nucleus-nucleus collisions have many features in common. Based upon this observation, a model for all these interactions is constructed which relies on the fundamental hypothesis that the behavior of high energy interactions is universal. (author)

  1. Designer's unified cost model

    Science.gov (United States)

    Freeman, William T.; Ilcewicz, L. B.; Swanson, G. D.; Gutowski, T.

    1992-01-01

    A conceptual and preliminary designers' cost prediction model has been initiated. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state of the art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a data base and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. The approach, goals, plans, and progress is presented for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

  2. Designers' unified cost model

    Science.gov (United States)

    Freeman, W.; Ilcewicz, L.; Swanson, G.; Gutowski, T.

    1992-01-01

    The Structures Technology Program Office (STPO) at NASA LaRC has initiated development of a conceptual and preliminary designers' cost prediction model. The model will provide a technically sound method for evaluating the relative cost of different composite structural designs, fabrication processes, and assembly methods that can be compared to equivalent metallic parts or assemblies. The feasibility of developing cost prediction software in a modular form for interfacing with state-of-the-art preliminary design tools and computer aided design programs is being evaluated. The goal of this task is to establish theoretical cost functions that relate geometric design features to summed material cost and labor content in terms of process mechanics and physics. The output of the designers' present analytical tools will be input for the designers' cost prediction model to provide the designer with a database and deterministic cost methodology that allows one to trade and synthesize designs with both cost and weight as objective functions for optimization. This paper presents the team members, approach, goals, plans, and progress to date for development of COSTADE (Cost Optimization Software for Transport Aircraft Design Evaluation).

  3. New Approaches to Treatment of Severe Intrauterine Growth Restriction

    Directory of Open Access Journals (Sweden)

    Zhanar Kurmangali

    2014-12-01

    Full Text Available Introduction. Intrauterine growth restriction (IUGR is a leading cause of perinatal morbidity and mortality due to placental insufficiency. Currently, one of the new approaches to treating this disease is the injection of nutrients to the fetus through intravascular port-systems (catheters.Objective. To assess the impact of nutrient injections as treatment to fetuses with severe growth retardation.Materials and methods. Pregnant women with IUGR (abdominal circumference (AC < 5th percentile with the absence of diastolic flow in the umbilical artery and a fetal gestational age of less than 30 weeks were randomly divided into two groups. The treatment group included six pregnant women who had an intravascular port-system for the infusion of nutrients (amino acids and glucose in the umbilical vein of the fetus for 14 ± 3 days. The control group consisted of eight patients who received only traditional dynamic monitoring and delivery at the optimum time of pregnancy. Fetal status was assessed using ultrasound equipment Accuvix V20 (Medison, South Korea by examining indicators of biometry and Doppler study of blood flow in utero, umbilical arteries, middle cerebral artery, and ductus venosus with fetal vascular resistance index calculation - pulsatility index (PI. Criteria for blood flow disturbances in the vessels were considered PI values above normal values for their gestational age, which were defined as absence or reverse blood flow in a diastole in the umbilical artery.Results. In a comparative analysis of the two groups, the treatment led to a 44.7% increase in AC of the fetus (121.0 ± 11.5 mm and 219.3 ± 18.3 mm, respectively, p ˂ 0.001. In all cases, the profile of blood flow in the umbilical artery had a positive diastolic component. As a result, there was a 45.3% decrease in PI in the umbilical artery (2.14 ± 0.54 and 1.17 ± 0.15, respectively, p < 0.05. Average fetal weight in the study group was not significantly higher than the

  4. Treatment Approach for Infection of Healed Fractures After Internal Fixation.

    Science.gov (United States)

    Lawrenz, Joshua M; Frangiamore, Salvatore J; Rane, Ajinkya A; Cantrell, William Alex; Vallier, Heather A

    2017-11-01

    To review the efficacy of a treatment approach for patients with infection and colonized implants after open reduction and internal fixation of fractures. Retrospective case series. Level one trauma center. Twenty patients were treated for wound infection with colonized implants after open reduction and internal fixation. Surgical debridement, removal of implants, and a short postoperative oral antibiotic course. The course of patients after surgical debridement and removal of implants, including culture results, antibiotic administration, and presence of recurrent clinical infection and radiographic union. Twenty patients had clinical presentations, including skin breakdown, serous drainage, purulent drainage and/or exposed implants, most commonly of the tibia (15 of 20). Mean time from index procedure to debridement with implant removal was 19.7 months. At the time of debridement and implant removal, 18 of 20 (90%) patients had a positive intraoperative culture (16 routine cultures and 2 broth cultures). The most common bacteria were Enterobacter cloacae (5/17) and methicillin-sensitive Staphylococcus aureus (4/17). All patients had soft tissue healing without signs of recurrent infection after mean follow up of 40 months after implant removal. Surgical debridement with implant removal plus a short oral antibiotic course is effective to resolve wound infection with a colonized implant in the setting of healed fracture after internal fixation. Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

  5. Post-fundoplication symptoms and complications: Diagnostic approach and treatment

    Directory of Open Access Journals (Sweden)

    S. Sobrino-Cossío

    2017-07-01

    Full Text Available Laparoscopic Nissen fundoplication is currently considered the surgical treatment of choice for gastroesophageal reflux disease (GERD and its long-term effectiveness is above 90%. Adequate patient selection and the experience of the surgeon are among the predictive factors of good clinical response. However, there can be new, persistent, and recurrent symptoms after the antireflux procedure in up to 30% of the cases. There are numerous causes, but in general, they are due to one or more anatomic abnormalities and esophageal and gastric function alterations. When there are persistent symptoms after the surgical procedure, the surgery should be described as “failed”. In the case of a patient that initially manifests symptom control, but the symptoms then reappear, the term “dysfunction” could be used. When symptoms worsen, or when symptoms or clinical situations appear that did not exist before the surgery, this should be considered a “complication”. Postoperative dysphagia and dyspeptic symptoms are very frequent and require an integrated approach to determine the best possible treatment. This review details the pathophysiologic aspects, diagnostic approach, and treatment of the symptoms and complications after fundoplication for the management of GERD. Resumen: En la actualidad la funduplicatura laparoscópica tipo Nissen se considera el tratamiento quirúrgico de elección para la enfermedad por reflujo gastroesofágico (ERGE y su efectividad a largo plazo es mayor del 90%. Dentro de los factores predictores de buena respuesta clínica están la adecuada selección del paciente y la experiencia del cirujano. Sin embargo, la prevalencia de síntomas nuevos, persistentes y recurrentes posteriores al procedimiento antirreflujo puede ser de hasta un 30%. Las causas son múltiples pero en general se deben a una o más alteraciones en la anatomía y en la función esofagogástrica. Ante la

  6. GUDM: Automatic Generation of Unified Datasets for Learning and Reasoning in Healthcare.

    Science.gov (United States)

    Ali, Rahman; Siddiqi, Muhammad Hameed; Idris, Muhammad; Ali, Taqdir; Hussain, Shujaat; Huh, Eui-Nam; Kang, Byeong Ho; Lee, Sungyoung

    2015-07-02

    A wide array of biomedical data are generated and made available to healthcare experts. However, due to the diverse nature of data, it is difficult to predict outcomes from it. It is therefore necessary to combine these diverse data sources into a single unified dataset. This paper proposes a global unified data model (GUDM) to provide a global unified data structure for all data sources and generate a unified dataset by a "data modeler" tool. The proposed tool implements user-centric priority based approach which can easily resolve the problems of unified data modeling and overlapping attributes across multiple datasets. The tool is illustrated using sample diabetes mellitus data. The diverse data sources to generate the unified dataset for diabetes mellitus include clinical trial information, a social media interaction dataset and physical activity data collected using different sensors. To realize the significance of the unified dataset, we adopted a well-known rough set theory based rules creation process to create rules from the unified dataset. The evaluation of the tool on six different sets of locally created diverse datasets shows that the tool, on average, reduces 94.1% time efforts of the experts and knowledge engineer while creating unified datasets.

  7. Unified theory of effective interaction

    Energy Technology Data Exchange (ETDEWEB)

    Takayanagi, Kazuo, E-mail: k-takaya@sophia.ac.jp

    2016-09-15

    We present a unified description of effective interaction theories in both algebraic and graphic representations. In our previous work, we have presented the Rayleigh–Schrödinger and Bloch perturbation theories in a unified fashion by introducing the main frame expansion of the effective interaction. In this work, we start also from the main frame expansion, and present various nonperturbative theories in a coherent manner, which include generalizations of the Brandow, Brillouin–Wigner, and Bloch–Horowitz theories on the formal side, and the extended Krenciglowa–Kuo and the extended Lee–Suzuki methods on the practical side. We thus establish a coherent and comprehensive description of both perturbative and nonperturbative theories on the basis of the main frame expansion.

  8. Split supersymmetry in unified models

    International Nuclear Information System (INIS)

    Dutta, Bhaskar; Mimura, Yukihiro

    2005-01-01

    In the context of split supersymmetry, the gaugino mass spectrum seems to be very important to satisfy the dark matter content of the universe and the gauge coupling unification. In this Letter, we have considered various sources of gaugino masses in the context of unified models. We show that the gaugino mass spectrum varies in different unification pictures. In the context of SU(5), we have found that the bino/wino mass ratio can be close to one at the weak scale which is helpful to satisfy the WMAP data. The gluino/wino mass ratio is also different from the usual scenario of unified gaugino masses. The gaugino masses can be around one TeV and m SUSY is chosen so that the gluino mass does not create any cosmological problem. In the context of the Pati-Salam model, we show that the gluino mass can be made very heavy even after maintaining the unification of the gauge couplings

  9. Unified theory of the nucleus

    International Nuclear Information System (INIS)

    Wildermuth, K.; Tang, Y.C.

    1977-01-01

    The purpose of this monograph is to describe a microscopic nuclear theory which can be used to consider all low-energy nuclear phenomena from a unified viewpoint. In this theory, the Pauli principle is completely taken into account and translationally invariant wave functions are always employed. It can be utilized to study reactions initiated not only by nucleons but also by arbitrary composite particles

  10. Cow-specific treatment of clinical mastitis: an economic approach

    NARCIS (Netherlands)

    Steeneveld, W.; Werven, van T.; Barkema, H.W.; Hogeveen, H.

    2011-01-01

    Under Dutch circumstances, most clinical mastitis (CM) cases of cows on dairy farms are treated with a standard intramammary antimicrobial treatment. Several antimicrobial treatments are available for CM, differing in antimicrobial compound, route of application, duration, and cost. Because cow

  11. Developing a dependable approach for evaluating waste treatment data

    International Nuclear Information System (INIS)

    Gering, K.L.

    1997-01-01

    Decision makers involved with hazardous waste treatment issues are faced with the challenge of making objective evaluations concerning treatment formulations. This work utilizes an effectiveness factor (denoted as η) as the basis for waste treatment evaluations, which was recently developed for application to mixed waste treatability studies involving solidification and stabilization at the Idaho National Engineering and Environmental Laboratory. The effectiveness factor incorporates an arbitrary treatment criterion Φ, which in practice could be the Toxicity Characteristic Leaching Procedure, Unconfined Compressive Strength, Leachability Index, or any other criterion used to judge treatment performance. Three values for Φ are utilized when assessing a given treatment formulation: before treatment, after treatment, and a reference value (typically a treatment standard). The expression for η also incorporates the waste loading as the prime experimental parameter, and accounts for the contribution that each hazard has upon the overall treatment performance. Also discussed are general guidelines for numerical boundaries and statistical interpretations of treatment data. Case studies are presented that demonstrate the usefulness of the effectiveness factor and related numerical methods, where the typical hazards encountered are toxic metals within mixed waste

  12. Uniframe: A Unified Framework for Developing Service-Oriented, Component-Based Distributed Software Systems

    National Research Council Canada - National Science Library

    Raje, Rajeev R; Olson, Andrew M; Bryant, Barrett R; Burt, Carol C; Auguston, Makhail

    2005-01-01

    .... It describes how this approach employs a unifying framework for specifying such systems to unite the concepts of service-oriented architectures, a component-based software engineering methodology...

  13. Current approaches and future directions in the treatment of leprosy

    Directory of Open Access Journals (Sweden)

    Worobec SM

    2012-08-01

    Full Text Available Sophie M WorobecDepartment of Dermatology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USAAbstract: This review surveys current treatments and future treatment trends in leprosy from a clinical perspective. The World Health Organization provides a multidrug treatment regimen that targets the Mycobacterium leprae bacillus which causes leprosy. Several investigational drugs are available for the treatment of drug-resistant M. leprae. Future directions in leprosy treatment will focus on: the molecular signaling mechanism M. leprae uses to avoid triggering an immune response; prospective studies of the side effects experienced during multiple-drug therapy; recognition of relapse rates post-completion of designated treatments; combating multidrug resistance; vaccine development; development of new diagnostic tests; and the implications of the recent discovery of a genetically distinct leprosy-causing bacillus, Mycobacterium lepromatosis.Keywords: epidemiology, leprosy, Hansen’s disease, multidrug resistance, multidrug therapy

  14. SUGERE - a unified system for waste management

    International Nuclear Information System (INIS)

    Silva, Eliane Magalhaes Pereira da; Vasconcelos, Vanderley de; Senne Junior, Murillo; Jordao, Elizabete

    2005-01-01

    Generation and disposal of wastes has been responsible for many economical, ecological and public health problems. In order to manage hazardous wastes in an environment friendly manner, many technical and administrative procedures should be implemented, including prevention, control of generation, and final disposal. A software named SUGERE - a unified system for waste management - is being developed. It is an easy to use tool that integrates all the steps involved in hazardous and radioactive waste management. This system is intended to help generators, transporters and owners of treatment, storage and disposal facilities to manage hazardous and radioactive wastes, by assuring compliance with environmental laws and consumer requirements. This paper presents the current status of the SUGERE software, developed using Borland Delphi package. The nuclear industry is used as a reference for developing this work. (author)

  15. [Malnutrition in anorexia nervosa: psychosomatic approach and multidisciplinary treatment].

    Science.gov (United States)

    Cabetas Hernández, I

    2004-01-01

    image, tend to undervalue their own, unable to withstand the development of the body or the internal tension this entails. Controlled exercise, improved nutrition and hormone treatment are currently the combined therapies applied in AN, with agreement being reached with patients on a specific personal diet of low volume, attempting to ensure the necessary minimum of fat and carbohydrates. With simultaneous psychological attention through an integral multidisciplinary approach in order to reduce the high prevalence of partially treated cases that accumulate over time.

  16. Water Supply Treatment Sustainability of Semambu Water Supply Treatment Process - Water Footprint Approach

    Science.gov (United States)

    Aziz, Edriyana A.; Malek, Marlinda Abdul; Moni, Syazwan N.; Hadi, Iqmal H.; Zulkifli, Nabil F.

    2018-03-01

    In this study, the assessment by using Water Footprint (WF) approach was conducted to assess water consumption within the water supply treatment process (WSTP) services of Semambu Water Treatment Plant (WTP). Identification of the type of WF at each stage of WSTP was carried out and later the WF accounting for the period 2010 – 2016 was calculated. Several factors that might influence the accounting such as population, and land use. The increasing value of total WF per year was due to the increasing water demand from population and land use activities. However, the pattern of rainfall intensity from the monsoonal changes was not majorly affected the total amount of WF per year. As a conclusion, if the value of WF per year keeps increasing due to unregulated development in addition to the occurrences of climate changing, the intake river water will be insufficient and may lead to water scarcity. The findings in this study suggest actions to reduce the WF will likely have a great impact on freshwater resources availability and sustainability.

  17. Treatment for primary hypothyroidism: current approaches and future possibilities

    Science.gov (United States)

    Chakera, Ali J; Pearce, Simon HS; Vaidya, Bijay

    2012-01-01

    Primary hypothyroidism is the most common endocrine disease. Although the diagnosis and treatment of hypothyroidism is often considered simple, there are large numbers of people with this condition who are suboptimally treated. Even in those people with hypothyroidism who are biochemically euthyroid on levothyroxine replacement there is a significant proportion who report poorer quality of life. This review explores the historical and current treatment options for hypothyroidism, reasons for and potential solutions to suboptimal treatment, and future possibilities in the treatment of hypothyroidism. PMID:22291465

  18. Cow-specific treatment of clinical mastitis: an economic approach.

    Science.gov (United States)

    Steeneveld, W; van Werven, T; Barkema, H W; Hogeveen, H

    2011-01-01

    Under Dutch circumstances, most clinical mastitis (CM) cases of cows on dairy farms are treated with a standard intramammary antimicrobial treatment. Several antimicrobial treatments are available for CM, differing in antimicrobial compound, route of application, duration, and cost. Because cow factors (e.g., parity, stage of lactation, and somatic cell count history) and the causal pathogen influence the probability of cure, cow-specific treatment of CM is often recommended. The objective of this study was to determine if cow-specific treatment of CM is economically beneficial. Using a stochastic Monte Carlo simulation model, 20,000 CM cases were simulated. These CM cases were caused by Streptococcus uberis and Streptococcus dysgalactiae (40%), Staphylococcus aureus (30%), or Escherichia coli (30%). For each simulated CM case, the consequences of using different antimicrobial treatment regimens (standard 3-d intramammary, extended 5-d intramammary, combination 3-d intramammary+systemic, combination 3-d intramammary+systemic+1-d nonsteroidal antiinflammatory drugs, and combination extended 5-d intramammary+systemic) were simulated simultaneously. Finally, total costs of the 5 antimicrobial treatment regimens were compared. Some inputs for the model were based on literature information and assumptions made by the authors were used if no information was available. Bacteriological cure for each individual cow depended on the antimicrobial treatment regimen, the causal pathogen, and the cow factors parity, stage of lactation, somatic cell count history, CM history, and whether the cow was systemically ill. Total costs for each case depended on treatment costs for the initial CM case (including costs for antibiotics, milk withdrawal, and labor), treatment costs for follow-up CM cases, costs for milk production losses, and costs for culling. Average total costs for CM using the 5 treatments were (US) $224, $247, $253, $260, and $275, respectively. Average probabilities

  19. Detection of consensuses and treatment principles of diabetic nephropathy in traditional Chinese medicine: A new approach

    Directory of Open Access Journals (Sweden)

    Xu Tong

    2015-10-01

    Conclusion: The results suggest that the community detection-based approach is useful and feasible for uncovering consensuses and treatment principles of DN treatment in TCM, and could be used to address other similar problems in TCM.

  20. The Intersystem Model of Psychotherapy: An Integrated Systems Treatment Approach

    Science.gov (United States)

    Weeks, Gerald R.; Cross, Chad L.

    2004-01-01

    This article introduces the intersystem model of psychotherapy and discusses its utility as a truly integrative and comprehensive approach. The foundation of this conceptually complex approach comes from dialectic metatheory; hence, its derivation requires an understanding of both foundational and integrational constructs. The article provides a…

  1. Einstein's theory of unified fields

    CERN Document Server

    Tonnelat, Marie Antoinette

    2014-01-01

    First published in1966, here is presented a comprehensive overview of one of the most elusive scientific speculations by the pre-eminent genius of the 20th century. The theory is viewed by some scientists with deep suspicion, by others with optimism, but all agree that it represents an extreme challenge. As the author herself affirms, this work is not intended to be a complete treatise or 'didactic exposition' of the theory of unified fields, but rather a tool for further study, both by students and professional physicists. Dealing with all the major areas of research whic

  2. A Cognitive-Behavioral Treatment Approach for Body Dysmorphic Disorder

    Science.gov (United States)

    Wilhelm, Sabine; Buhlmann, Ulrike; Hayward, Laura C.; Greenberg, Jennifer L.; Dimaite, Ruta

    2010-01-01

    Although body dysmorphic disorder (BDD) has been described in the literature for more than a century, there has been only a limited focus on the development of cognitive behavioral treatments for BDD. Our case report provides a detailed description of a course of cognitive behavioral treatment (CBT) for an individual with BDD. The patient was…

  3. Treatment of Conduct Disorder with a Multisystemic and Multimodal Approach

    Science.gov (United States)

    Ubinger, Nicole

    2006-01-01

    Conduct disorder is a childhood disorder that is often resistant to treatment. Current treatment methods often focus on separate interventions for each environment that the child or adolescent is exhibiting antisocial behavior. Additionally the focus is on the behavior of the child and often does not focus on the family unit or the biology behind…

  4. Psychological approaches in the treatment of specific phobias: A meta-analysis

    NARCIS (Netherlands)

    Wolitzky-Taylor, K.B.; Horowitz, J.D.; Powers, M.B.; Telch, M.J.

    2008-01-01

    Data from 33 randomized treatment studies were subjected to a meta-analysis to address questions surrounding the efficacy of psychological approaches in the treatment of specific phobia. As expected, exposure-based treatment produced large effects sizes relative to no treatment. They also

  5. A Fuzzy PROMETHEE Approach for Breast Cancer Treatment Techniques

    Directory of Open Access Journals (Sweden)

    Dilber Uzun Ozsahin

    2018-05-01

    Full Text Available Breast tumor is a growth that occur in the healthy breast tissue, whereby abnormal cells undergo division in an uncontrolled manner. It comes in different types and stages and the ability to metastasize and infect distant tissues. Several studies have showed that one in eight women in the US have develop breast cancer during their life time. Therefore, early diagnosis and treatment is widely approved as being essential to effectively alleviate the disease. The aim of this study is to comparatively analyze certain breast cancer treatment procedures which include surgery, hormone therapy, chemotherapy, and radiation therapy. Fuzzy PROMETHEE (preference ranking organization method for enrichment of evaluations a multi-criteria decision-making process was used to evaluate the treatments on factors that include side effects, overall survival rate, cost of treatment and treatment time.

  6. Pharmacological Approaches for Treatment-resistant Bipolar Disorder

    Science.gov (United States)

    Poon, Shi Hui; Sim, Kang; Baldessarini, Ross J.

    2015-01-01

    Bipolar disorder is prevalent, with high risks of disability, substance abuse and premature mortality. Treatment responses typically are incomplete, especially for depressive components, so that many cases can be considered “treatment resistant.” We reviewed reports on experimental treatments for such patients: there is a striking paucity of such research, mainly involving small incompletely controlled trials of add-on treatment, and findings remain preliminary. Encouraging results have been reported by adding aripiprazole, bupropion, clozapine, ketamine, memantine, pramipexole, pregabalin, and perhaps tri-iodothyronine in resistant manic or depressive phases. The urgency of incomplete responses in such a severe illness underscores the need for more systematic, simpler, and better controlled studies in more homogeneous samples of patients. PMID:26467409

  7. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

    Science.gov (United States)

    Mamo, Tewodros; Moseman, E Ashley; Kolishetti, Nagesh; Salvador-Morales, Carolina; Shi, Jinjun; Kuritzkes, Daniel R; Langer, Robert; von Andrian, Ulrich

    2010-01-01

    Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century. It has a vast potential to radically advance the treatment and prevention of HIV/AIDS. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for HIV/AIDS by advancing antiretroviral therapy, gene therapy, immunotherapy, vaccinology and microbicides. PMID:20148638

  8. Green Walls as an Approach in Grey Water Treatment

    Science.gov (United States)

    Rysulova, Martina; Kaposztasova, Daniela; Vranayova, Zuzana

    2017-10-01

    Grey water contributes significantly to waste water parameters such as biochemical oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS), total phosphorus (Ptotal), total nitrogen (Ntotal), ammonium, boron, metals, salts, surfactants, synthetic chemicals, oils and greases, xenobiotic substances and microorganisms. Concentration of these pollutants and the water quality highlights the importance of treatment process in grey water systems. Treatment technologies operating under low energy and maintenance are usually preferred, since they are more cost effective for users. Treatment technologies based on natural processes represent an example of such technology including vegetated wall. Main aim of this paper is to introduce the proposal of vegetated wall managing grey water and brief characteristic of proposed system. Is expected that prepared experiment will establish the purifying ability and the potential of green wall application as an efficient treatment technology.

  9. Treatment of premature ejaculation: a new combined approach

    Directory of Open Access Journals (Sweden)

    Adel Kurkar

    2015-01-01

    Causes of PE differ considerably. In this paper, we compared the outcomes of two single treatment lines together with a combination of both. The combination therapy was more effective than either line alone.

  10. Current treatment approaches in patients with ankylosing spondylitis

    Directory of Open Access Journals (Sweden)

    Bilal Elbey

    2015-03-01

    Full Text Available Ankylosing spondylitis (AS is a chronic, inflammatory, rheumatic disease that mainly affects sacroiliac joints and spine. AS predominantly occurs more often in males and typically begins in the second or third decade. The mainstay of therapy in AS are nonsteroidal anti-inflammatory drugs, which reduce inflammation and pain. Disease modifying antirheumatic drugs (DMARD did not have enough evidence to prove their effect in AS treatment. The use of DMARD may not sufficient to improve the treatment and symptoms. Currently, TNF-blockers such as, Golimumab Etanersept Adalimumab İnfliksimab have promising results in the treatment of AS. TNF-blockers improve the clinical signs and symptoms, and improve the patients’ physical function and quality of life. This manuscript is focused that Current pharmacological treatments in patients with ankylosing spondylitis.

  11. Lupus nephritis: An approach to diagnosis and treatment in South ...

    African Journals Online (AJOL)

    In all patients, treatment should include adjunctive therapies such as renin angiotensin aldosterone system .... Switching to an alternative agent is recommended for ... gastritis, cataracts, avascular necrosis of femur, cushingoid appearance.

  12. Acoustic Wave Treatment For Cellulite—A New Approach

    Science.gov (United States)

    Russe-Wilflingseder, Katharina; Russe, Elisabeth

    2010-05-01

    Background and Objectives: Cellulite is a biological caused modification of the female connective tissue. In extracorporeal shockwave therapy (ESWT) pulses are penetrating into the tissue without causing a thermal effect or micro lesions, but leading to a stimulation of tissue metabolism and blood circulation, inducing a natural repair process with cell activation and stem cells proliferation. Recently ESWT treatment showed evidence of remodelling collagen within the dermis and of stimulating microcirculation in fatty tissue. Study Design and Methods: The study was designed to assess acoustic wave treatment for cellulite by comparison treated vs. untreated side (upper-leg and buttock). Each individual served as its own control. 11 females with a BMI less then 30 and an age over 18 years were included. 6 treatments were given weekly with radial acoustic waves. Documentation was done before and 1, 4, 12 weeks after last treatment by standardized photo documentation, relaxed and with muscle contraction, measurement of body weight and circumference of the thigh, pinch test, and evaluation of hormonal status and lifestyle. The efficacy of AWT/EPAT was evaluated before and 1, 4, 12 weeks after last treatment. Patients rated the improvement of cellulite, overall satisfaction and acceptance. The therapist assessed improvement of cellulite, side effects and photo documentation treated vs. untreated side, before vs. after treatment. The blinded investigator evaluated the results using photo documentation right vs. left leg, before vs. after treatment in a frontal, lateral and dorsal view, relaxed and with muscle contraction. Results: The improvement of cellulite at the treated side was rated by patients with 27,3% at week 4 and 12, by the therapist with 34,1% at week 4 and 31,2% at week 12 after the last treatment The blinded investigator could verify an improvement of cellulite in an increasing number of patients with increasing time interval after treatment. No side

  13. FUNCTIONAL FECAL INCONTINENCE IN CHILDREN (DIFFERENTIAL DIAGNOSTICS AND TREATMENT APPROACHES

    Directory of Open Access Journals (Sweden)

    V.N. Kopeikin

    2009-01-01

    Full Text Available Impairment of the intestinal content continence, a common clinical situation with various pathogenetic mechanisms. Disease proceeds with the child’s maladjustment events. 33 cases of encopresis have been analyzed. This condition has various clinical and instrumental diagnostic criteria depending on the origin which simplifies differential diagnostics. Using a differential diagnostics table helps expedite the process of making a diagnosis and hence start an adequate treatment in a timely manner.Key words: encopresis, differential diagnostics, treatment, children.

  14. Current approaches to the treatment of Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Joseph Jankovic

    2008-09-01

    Full Text Available Joseph Jankovic, L Giselle AguilarParkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of MedicineAbstract: Enormous progress has been made in the treatment of Parkinson’s disease (PD. As a result of advances in experimental therapeutics, many promising therapies for PD are emerging. Levodopa remains the most potent drug for controlling PD symptoms, yet is associated with significant complications such as the “wearing off” effect, levodopa-induced dyskinesias and other motor complications. Catechol-o-methyl-transferase inhibitors, dopamine agonists and nondopaminergic therapy are alternative modalities in the management of PD and may be used concomitantly with levodopa or one another. The neurosurgical treatment, focusing on deep brain stimulation, is reviewed briefly. Although this review has attempted to highlight the most recent advances in the treatment of PD, it is important to note that new treatments are not necessarily better than the established conventional therapy and that the treatment options must be individualized and tailored to the needs of each individual patient.Keywords: Parkinson’s disease, levodopa, medical treatment, pallidotomy, deep brain stimulation

  15. Unified Health Gamification can significantly improve well-being in corporate environments.

    Science.gov (United States)

    Shahrestani, Arash; Van Gorp, Pieter; Le Blanc, Pascale; Greidanus, Fabrizio; de Groot, Kristel; Leermakers, Jelle

    2017-07-01

    There is a multitude of mHealth applications that aim to solve societal health problems by stimulating specific types of physical activities via gamification. However, physical health activities cover just one of the three World Health Organization (WHO) dimensions of health. This paper introduces the novel notion of Unified Health Gamification (UHG), which covers besides physical health also social and cognitive health and well-being. Instead of rewarding activities in the three WHO dimensions using different mHealth competitions, UHG combines the scores for such activities on unified leaderboards and lets people interact in social circles beyond personal interests. This approach is promising in corporate environments since UHG can connect the employees with intrinsic motivation for physical health with those who have quite different interests. In order to evaluate this approach, we realized an app prototype and we evaluated it in two corporate pilot studies. In total, eighteen pilot users participated voluntarily for six weeks. Half of the participants were recruited from an occupational health setting and the other half from a treatment setting. Our results suggest that the UHG principles are worth more investigation: various positive health effects were found based on a validated survey. The mean mental health improved significantly at one pilot location and at the level of individual pilot participants, multiple other effects were found to be significant: among others, significant mental health improvements were found for 28% of the participants. Most participants intended to use the app beyond the pilot, especially if it would be further developed.

  16. Novel pharmacological approaches for the treatment of acne vulgaris.

    Science.gov (United States)

    Valente Duarte de Sousa, Isabel Cristina

    2014-10-01

    Acne vulgaris is the most common skin disease worldwide; yet, current treatment options, although effective, are associated with unwanted side effects, chronicity, relapses and recurrences. The adequate control of the four pathogenic mechanisms, involved in the appearance of acne lesions, is paramount to treatment success. The authors discuss and evaluate the pathogenic pathways related to the mechanisms of action of novel molecules, which are currently under investigation for the treatment of acne vulgaris. The manuscript is based on comprehensive searches made through PubMed, GoogleScholar and ClinicalTrial.gov, using different combination of key words, which include acne vulgaris, pathogenesis, treatment, sebogenesis and Propionibacterium acnes. In the near future, more effective treatments with fewer side effects are expected. The use of topical antiandrogens, acetylcholine inhibitors and PPAR modulators seem to be promising options for controlling sebum production. Retinoic acid metabolism-blocking agents and IL-1α inhibitors have the potential to become legitimate alternative options to retinoid therapy in the management of infundibular dyskeratosis. Indeed, the authors believe that there will likely be a decline in the use of antibiotics for controlling P. acnes colonization and targeting the inflammation cascade.

  17. An Approach for Practical Multiobjective IMRT Treatment Planning

    International Nuclear Information System (INIS)

    Craft, David; Halabi, Tarek; Shih, Helen A.; Bortfeld, Thomas

    2007-01-01

    Purpose: To introduce and demonstrate a practical multiobjective treatment planning procedure for intensity-modulated radiation therapy (IMRT) planning. Methods and Materials: The creation of a database of Pareto optimal treatment plans proceeds in two steps. The first step solves an optimization problem that finds a single treatment plan which is close to a set of clinical aspirations. This plan provides an example of what is feasible, and is then used to determine mutually satisfiable hard constraints for the subsequent generation of the plan database. All optimizations are done using linear programming. Results: The two-step procedure is applied to a brain, a prostate, and a lung case. The plan databases created allow for the selection of a final treatment plan based on the observed tradeoffs between the various organs involved. Conclusions: The proposed method reduces the human iteration time common in IMRT treatment planning. Additionally, the database of plans, when properly viewed, allows the decision maker to make an informed final plan selection

  18. Pressure sores--a multifaceted approach to prevention and treatment.

    Science.gov (United States)

    Staas, W. E.; Cioschi, H. M.

    1991-01-01

    The incidence and effect of pressure sores on the disabled and elderly population have created a challenge to physicians and health care professionals, from emergency departments to rehabilitation units, and in the community. If not prevented, the morbidity and mortality of patients and the direct and indirect costs to both patients and the health care system are radically increased. In this article we define the impact on our health care system of pressure sores, provide an overview of a multifaceted approach to their prevention and management, and introduce successful behavioral and educational approaches for patients with chronic, recurrent sores. A coordinated approach with patients as informed participants and their care givers enhances the chances for success. PMID:1830985

  19. BACK PAIN ASSOCIATED WITH OSTEOPOROSIS — TREATMENT PATTERNS, APPROACHES TO THERAPY

    Directory of Open Access Journals (Sweden)

    N. A. Shostak

    2014-07-01

    Full Text Available The article highlights current approaches to diagnosis and treatment of back pain, associated with osteoporosis. An algorithm for management of patients with vertebral compression fracture, complicated by pain, the main approaches to drug treatment of back pain and osteoporosis are described.

  20. [Our current approach in the treatment of sigmoid colon volvulus].

    Science.gov (United States)

    Taviloğlu, Korhan; Aydin, Erol; Ertekin, Cemalettin; Güloğlu, Recep; Kurtoğlu, Mehmet

    2002-04-01

    Our aim was to emphasize the role of endoscopic detorsion in the treatment of sigmoid colon volvulus, which we currently apply in the majority of our cases. The data of 37 patients were analyzed in a retrospective manner, during a 86-month period, between May 1994 and July 2001. The patients were classified into three groups. The first group consisted of 9 patients with resection and anastomosis, the second group consisted of 20 patients with Hartmann's procedure, and the third group consisted of 8 patients with endoscopic detorsion. Complications were encountered in 7 patients (19%), and 3 patients (8%) died following treatment. We favor colonic resection following endoscopic treatment. Resection should be preferred, if endoscopic detorsion is not successful or in the presence of a complication.

  1. Plasma Onco-Immunotherapy: Novel Approach to Cancer Treatment

    Science.gov (United States)

    Fridman, Alexander

    2015-09-01

    Presentation is reviewing the newest results obtained by researchers of A.J. Drexel Plasma Institute on direct application of non-thermal plasma for direct treatment of different types of cancer by means of specific stimulation of immune system in the frameworks of the so-called onco-immunotherapy. Especial attention is paid to analysis of depth of penetration of different plasma-medical effects, from ROS, RNS, and ions to special biological signaling and immune system related processes. General aspects of the plasma-stimulation of immune system are discussed, pointing out specific medical applications. Most of experiments have been carried out using nanosecond pulsed DBD at low power and relatively low level of treatment doses, guaranteeing non-damage no-toxicity treatment regime. The nanosecond pulsed DBD physics is discussed mostly regarding its space uniformity and control of plasma parameters relevant to plasma medical treatment, and especially relevant to depth of penetration of different plasma medical effects. Detailed mechanism of the plasma-induced onco-immunotherapy has been suggested based upon preliminary in-vitro experiments with DBD treatment of different cancer cells. Sub-elements of this mechanism related to activation of macrophages and dendritic cells, specific stressing of cancer cells and the immunogenic cell death (ICD) are to be discussed based on results of corresponding in-vitro experiments. In-vivo experiments focused on the plasma-induced onco-immunotherapy were carried out in collaboration with medical doctors from Jefferson University hospital of Philadelphia. Todays achievements and nearest future prospective of clinical test focused on plasma-controlled cancer treatment are discussed in conclusion.

  2. Psychosocial Aspects of Adolescent Dysphonia: An Approach to Treatment.

    Science.gov (United States)

    Beery, Quinter C.

    1991-01-01

    This paper presents an approach to voice therapy with adolescents, emphasizing the importance of psychosocial and family influences as they relate to vocal behavior. The goals of therapy for the adolescent with dysphonia usually follow an orderly sequence, first dealing with individual behavior and later with family and peer group influences. (JDD)

  3. A Psychoeducational Approach in the Treatment of Anorexia Nervosa.

    Science.gov (United States)

    Cotugno, Albert J.

    1980-01-01

    Anorexia nervosa exists as a clinical entity with significant ego disturbances which appear as primary features. Noneating and accompanying weight loss are often secondary features of the disturbance. The psychoeducational approach is most valuable because it integrates the psychological view with educational goals. (Author)

  4. Re-expasion pulmonary edema and its treatment approaches ...

    African Journals Online (AJOL)

    Indomethacin suppositories were administered to 11(55%) patients. Twenty-five percent of RPE cases required bronchodilators while only one case (5%) had received a bronchodilator drug. We concluded that RPE is not a rare complication. Early diagnosis and appropriate approach can reduce mortality. For patients with ...

  5. Eating disorders: Insights from imaging and behavioral approaches to treatment.

    Science.gov (United States)

    Stice, Eric; Shaw, Heather

    2017-11-01

    Understanding factors that contribute to eating disorders, which affect 13% of females, is critical to developing effective prevention and treatment programs. In this paper, we summarize results from prospective studies that identified factors predicting onset and persistence of eating disorders and core symptom dimensions. Next, implications for intervention targets for prevention, and treatment interventions from the risk- and maintenance-factor findings are discussed. Third, given that evidence suggests eating disorders are highly heritable, implying biological risk and maintenance factors for eating disorders, we offer working hypotheses about biological factors that might contribute to eating disorders, based on extant risk factor findings, theory, and cross-sectional studies. Finally, potentially fruitful directions for future research are presented. We suggest that it would be useful for experimental therapeutics trials to evaluate the effects of reducing the risk factors on future onset of eating pathology and on reducing maintenance factors on the risk for persistence of eating pathology, and encourage researchers to utilize prospective high-risk studies so that knowledge regarding potential intervention targets for prevention and treatment interventions for eating disorders can be advanced. Using the most rigorous research designs should help improve the efficacy of prevention and treatment interventions for eating disorders.

  6. Childhood obesity treatment and prevention. Psychological perspectives of clinical approaches

    OpenAIRE

    Maria Catena Quattropani; Teresa Buccheri

    2013-01-01

    Objective: This work focuses on clinical psychologist’ presence within childhood obesity prevention programmes in several countries. Method: The Authors collected articles considering psychological, biological and social aspects linked to childhood obesity. Results: Studies reveal that childhood obesity prevention programmes are based on biological, medical and educational aspects; clinical psychologists up until now have been engaged almost exclusively in the treatment of obesity. Conclusion...

  7. Humanistic Approaches to the Understanding and Treatment of Anorexia Nervosa.

    Science.gov (United States)

    Dittmar, Helga; Bates, Brian

    1987-01-01

    Summarizes some attempts to understand the causes and consequent treatments of anorexia nervosa from the viewpoints of psychoanalytically informed, family, existential and feminist psychology. These perspectives, which focus on the individual experience of the anorexic, leave many questions unanswered, but provide fresh frameworks from which to…

  8. A Family Approach to Treatment of Postpartum Depression

    Science.gov (United States)

    McKay, Judith; Shaver-Hast, Laura; Sharnoff, Wendy; Warren, Mary Ellen; Wright, Harry

    2009-01-01

    Postpartum depression (PPD) has an impact on the entire family. The authors describe a model of intervention that emphasizes the family system and includes mothers, fathers, and children in the treatment of PPD. The intervention is provided by a multidisciplinary team consisting of a psychiatrist, social worker, child psychologist, and therapists.…

  9. Towards personalized treatment in cardiovascular disease : a molecular epidemiological approach

    NARCIS (Netherlands)

    Regieli, J.J.

    2009-01-01

    Patients who have experienced cardiovascular disease each differ in terms of their future risk, yet currently we have no ways to predict individual prognosis. Mass preventive treatment is therefore currently recommended for the group as a whole whereas in fact this group is highly heterogeneous and

  10. Current pharmacotherapeutic approaches for the treatment of Tourette syndrome.

    Science.gov (United States)

    Egolf, A; Coffey, B J

    2014-02-01

    Tourette syndrome is a childhood onset neurodevelopmental disorder characterized by multiple motor and vocal tics. Although many youth experience attenuation or even remission of tics in adolescence and young adulthood, some individuals experience persistent tics which can be debilitating or disabling. The majority of patients also have one or more psychiatric comorbid disorders, such as attention deficit hyperactivity disorder and/or obsessive-compulsive disorder. Treatment is multimodal, including both pharmacotherapy and cognitive behavioral treatment, and requires disentanglement of tics and the comorbid symptoms. Although the only two formally approved medications in the United States are haloperidol and pimozide, these treatments are generally not used as first-line interventions due to their significant potential for adverse effects. The α-adrenoceptor agonists guanfacine and clonidine have an established evidence base for both efficacy and tolerability, and are usually recommended as initial pharmacotherapy. Atypical neuroleptics, such as aripiprazole or risperidone, are typically used if the α-adrenoceptor agonists are ineffective or intolerable. However, many other pharmacological agents reviewed in this manuscript have been studied as treatment alternatives. Copyright 2014 Prous Science, S.A.U. or its licensors. All rights reserved.

  11. Mathematical modelling approach to the treatment of insulin ...

    African Journals Online (AJOL)

    Medical scientists have various ways of handling cases of insulin-dependent diabetes diseases of which one of the most popularly used methods is carrying out experiments on the patient. However, each time a case is presented, the need for fresh experiment to determine the treatment procedure will arise. To therefore ...

  12. Multimodal Therapy for Anorexia Nervosa: An Holistic Approach to Treatment.

    Science.gov (United States)

    O'Keefe, Edward J.; Castaldo, Christine

    1985-01-01

    Anorexia nervosa has received considerable attention lately because of its increased incidence, potential danger, and resistance to treatment. A review of the literature on anorexia nervosa suggests that, although it is characterized by complex interrelated psychological and physiological processes, it is often conceptualized and treated in…

  13. A holistic approach to the treatment of irritable bowel syndrome ...

    African Journals Online (AJOL)

    Group 1 (n = 13) received IBS medication and holistic psychotherapy, Group 2 (n = 23) received IBS medication only, Group 3 (n = 13) received holistic psychotherapy only and Group 4 (n = 21) received no treatment until the study was completed. During the intervention phase the relevant participants received one-hour ...

  14. Cartoon Hypnotherapy: An Innovative Treatment Approach for Childhood Emotional Disturbances.

    Science.gov (United States)

    Crowley, Richard J.; Mills, Joyce C.

    Cartoon research includes the areas of experimental designs carried out in school classroom environments to determine the effects of cartoon viewing on children's behavior and the medical utilization of cartoons as part of an overall treatment program. This study differs from previous research by accepting the reality of cartoon viewing and…

  15. Cough in Children: Current Approaches to the Treatment

    Directory of Open Access Journals (Sweden)

    O.O. Rechkina

    2016-03-01

    Full Text Available Introduction. Cough is one of the most common symptoms in the practice of doctors of various specialties, including pediatricians. Cough treatment should be started with the identification of its cause and correct diagnosis. Most often, cough in children is due to the increased viscosity of bronchial secretions, i.e. violation of sputum transport in the bronchial tree, and insufficient activity of ciliated epithelium. The main objective of the treatment of productive cough is dilution of sputum, bronchial secretion and excretion, thus necessitating the administration of mucolytics. Currently, one of the most famous mucolytics is acetylcysteine, cysteine amino acid product, such as ACC®. However, today the question of ACC® (acetylcysteine application in infants and young children is still debatable. This article presents a study whose objective was to evaluate the therapeutic efficacy and tolerability of ACC® (20 mg/ml solution in the treatment of bronchopulmonary diseases in children aged 2 to 6 years. Materials and methods. The study involved 60 children with acute tracheitis, simple bronchitis, acute obstructive bronchitis, recurrent bronchitis in the acute phase, community-acquired pneumonia, asthma exacerbation, cystic fibrosis. Patients of the main groups (n = 40 received ACC® (20 mg/ml solution at the age-specific dosage 3 times a day in combined treatment. Therapy of patients in the control group (n = 20 was conducted without ACC®. Results. During follow-up, patients who received ACC® had significant positive changes in the nature of cough, sputum viscosity and its amount as opposed to a comparison group of patients. Complete disappearance of cough was achieved on day 5–8 from the beginning of treatment, while in the control group patients, this time was longer. The evaluation of the effectiveness of the study drug showed that very good efficacy was achieved in 75 % of patients and good — in 20 %, and among patients who

  16. Towards a Unified Programming Language

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    2000-01-01

    The goal of research in programming languages should be to develop languages that integrates the best of concepts and constructs from the various programming paradigms. We do not argue for a multi-paradigm language, where the programmer alternates between the different paradigms/styles. Instead, we...... find that the languages of the future should integrate the best available concepts and constructs in such a way that the programmer does not think of multiple paradigms when using a given language. In this paper, we describe to what extent the BETA language has been successful in obtaining a unified...... style and where more research is needed. In addition to traditional paradigms such as object-oriented-, imperative-functional- and logic programming, we also discuss concurrent programming and prototype-based programming. We discuss language features such as the BETA pattern construct, virtual...

  17. A unified plant information network

    International Nuclear Information System (INIS)

    Niederauer, G.F.

    1986-01-01

    Technology is bringing power plants fully into the age of computerization. Microcomputers, data base managers, networking, and friendly, expert software are principal technology factors. Monitoring will improve, and the number and power of computers is increasing. The huge information flow will cause computers to be integrated into a communication network. The total plant operating triangle includes process, engineering, and management systems. The total network will integrate all of these into a Total Unified Plant Information Network (TUPIN). Software will take the type of information beyond monitored data. Analysis will improve through direct access to logical, physical, and procedural models by end users. Information management will improve through widespread use of hierarchical, relational, and expert data base managers. Expert systems will aid in diagnostics and interpretation. The goal is to automate plant operations to enhance safety and performance and to reduce cost by making both the plants and the personnel more expert

  18. Cosmology and unified gauge theory

    Science.gov (United States)

    Oraifeartaigh, L.

    1981-09-01

    Theoretical points in common between cosmology and unified gauge theory (UGT) are reviewed, with attention given to areas of one which have proven useful for the other. The underlying principles for both theoretical frameworks are described, noting the differences in scale, i.e., 10 to the 25th cm in cosmology and 10 to the -15th cm for UGT. Cosmology has produced bounds on the number of existing neutrino species, and also on the mass of neutrinos, two factors of interest in particle physics. Electrons, protons, and neutrinos, having been spawned from the same massive leptons, each composed of three quarks, have been predicted to be present in equal numbers in the Universe by UGT, in line with necessities of cosmology. The Grand UGT also suggests specific time scales for proton decay, thus accounting for the observed baryon assymmetry.

  19. Unifying physical concepts of reality

    Energy Technology Data Exchange (ETDEWEB)

    Gilbert, T.L.

    1983-08-01

    Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences.

  20. Phenomenology of unified gauge theories

    International Nuclear Information System (INIS)

    Ellis, J.

    1983-01-01

    Part I of these lectures treats the standard Glashow-Weinberg-Salam model of weak and electromagnetic interactions, discussing in turn its basic structure and weak neutral currents, charged currents, mixing angles and CP violation, and the phenomenology of weak vector and Higgs bosons. Part II of the lectures discusses the structure of theories of dynamical symmetry breaking such as technicolour, phenomenological consequences, frustrations and alternatives. The third part of these lectures offers the standard menu of grand unified theories (GUTs) of the strong, weak and electromagnetic interactions, including an hors d'oeuvre of constraints on the parameters of the standard model, a main course of baryon number violating processes, and desserts which violate lepton number and CP. The fourth and final part goes through different attempts to remedy the inadequacies of previous theories by invoking supersymmetry and reaching out towards gravitation. (orig./HSI)

  1. Unifying physical concepts of reality

    International Nuclear Information System (INIS)

    Gilbert, T.L.

    1983-01-01

    Physics may be characterized as the science of matter and energy. It anchors the two ends of the frontiers of science: the frontier of the very small and the frontier of the very large. All of the phenomena that we observe and study at the frontiers of science - all external experiences - are manifestations of matter and energy. One may, therefore, use physics to exemplify both the diversity and unity of science. This theme will be developed in two separate examples: first by sketching, very briefly, the historical origins of frontiers of the very small and very large and the converging unity of these two frontiers; and then by describing certain unifying concepts that play a central role in physics and provide a framework for relating developments in different sciences

  2. Unified gauge theories with spontaneous symmetry breaking

    International Nuclear Information System (INIS)

    MacDowell, S.W.

    1975-01-01

    Unified gauge theories with spontaneous symmetry breaking are studied with a view to renormalize quantum field theory. Georgi-Glashow and Weinberg-Salam models to unify weak and electromagnetic interactions are discussed in detail. Gauge theories of strong interactions are also considered [pt

  3. A new approach for treatment of xenon problem

    International Nuclear Information System (INIS)

    Mihailescu, Nicolae

    1999-01-01

    It is known that the fission product xenon 135, with a half life of 9.17 hours, has a very large absorption cross section for thermal neutrons. A small fraction of this nuclear species is formed directly in fission, but the major part results from the decay of iodine 135 with a half life of 6.59 hours. In this paper we shall present the 'fundamental' theory of an 'adiabatic' approach which appears to be promising both in cutting down computational time and in giving additional physical insight into the combined spatial-temporal variations. An adiabatic motivation is implicit in early work on reactor kinetics in which the reactor flux is separated into a product of a time dependent function and a function of all the other relevant variables, including the time; if the latter factor is slowly varying in time the approach is 'adiabatic'. (author)

  4. A unifying philosophy of governance

    Directory of Open Access Journals (Sweden)

    Sankarshan Acharya

    2012-09-01

    Full Text Available Bertrand Russell won Nobel Prize for arguing that science has triumphed over religion. Since religions are based on god, Russell’s argument implies that science has triumphed over both religion and god. But neither Russell nor anyone else has ever defined religion and god, rationally. The assertion about triumph of science (which is founded on rationality over concepts such as religion and god (which are not defined rationally or scientifically in the extant literature cannot be rational. This paper offers a novel rational philosophical foundation for the concepts of god, religion and science in which the claim that science triumphs over religion is redundant. This paper also presents substantial new insights about epistemic truths to help resolve current problems facing humanity like financial moral hazard and terrorism which have unnerved nations worldwide. The humanity now begs to answer a fundamental question of how we can govern ourselves. This paper offers a coherent set of credible answers. In particular, it offers a coherent unified philosophy about how humans have universally formed beliefs to govern themselves and how this philosophy could help resolve current problems. The universal rendering of beliefs articulated here subsumes the extant characterization of probability beliefs in mathematics, science, engineering, economics, religion and philosophy. The universal beliefs so articulated in this paper obviate the currently prevalent philosophical conflicts between religion and science or between theism and atheism and paves the way for optimal governance for prosperity amid stability. This philosophy also offers a rational characterization of the spiritual notion of Nirvana or salvation of the soul and the notion of epistemic truth. The unifying philosophy can help humanity achieve unity, stability and prosperity, sans financial moral hazard, antagonism, wars, nuclear proliferation, global warming and atmospheric pollution.

  5. Toward a Unified AGN Structure

    Science.gov (United States)

    Kazanas, Demosthenes; Fukumura, Keigo; Shrader, Chris; Behar, Ehud; Contopoulosa, Ioannis

    2012-01-01

    We present a unified model for the structure and appearance of accretion powered sources across their entire luminosity range from galactic X-ray binaries (XRB) to luminous quasars, with emphasis on AG N and their phenomenology. Central to this model is the notion of MHD winds launched by the accretion disks that power these objects. These winds provide the matter that manifests as blueshifted absorption features in the UV and X-ray spectra of a large fraction of these sources; furthermore, their density distribution in the poloidal plane determines their "appearance" (i.e. the column and velocity structure of these absorption features and the obscuration of the continuum source) as a function of the observer inclination angle (a feature to which INTEGRAL has made significant contributions). This work focuses on just the broadest characteristics of these objects; nonetheless, it provides scaling laws that allow one to reproduce within this model the properties of objects extending in luminosity from luminous quasars to XRBs. Our general conclusion is that the AGN phenomenology can be accounted for in terms of three parameters: The wind maSS flux in units of the Eddington value, m(dot), the observers' inclination angle Theta and the logarithmic slope between the 0/UV and X-ray fluxes alpha(sub ox); however because of a correlation between alpha(sub ox) and UV luminosity the number of significant parameters is two. The AGN correlations implied by this model appear to extend to and consistent with the XRB phenomenology, suggesting the presence of a truly unified underlying structure for accretion powered sources.

  6. Habitual biting of oral mucosa: A conservative treatment approach

    Directory of Open Access Journals (Sweden)

    Sarabjot Kaur Bhatia

    2013-01-01

    Full Text Available Chronic biting of oral mucosa is an innocuous self inflicted injury, commonly seen in children suffering from developmental and psychological problems and has rarely been reported in normal unaffected individuals. The management strategies vary from counseling, prescription of sedatives to different prosthetic shields. The paper highlights the efficacy of a simple approach using soft mouth guard in the management of self inflicted lesions due to habitual biting of oral mucosa in two normal healthy children.

  7. Differential approach to treatment of primary nocturnal enuresis in children

    Directory of Open Access Journals (Sweden)

    Nesterenko O.V.

    2011-09-01

    Full Text Available The aim of the work is to develop an algorithm of differentiated therapy in children with PNE. 234 children aged 5-15 years were studied. Results of treatment of children with primary nocturnal enuresis using the traditional therapeutic scheme and the algorithm of differential therapy based on identification of individual pathology were analyzed. The best clinical effect (recovery— in 73,1%, improvement— in 19,4% of cases was obtained in children undergone the complex of recommended measures: psychological consultation, rational and family psychotherapy, medication correction, physical and physiotherapy, alarm-monitoring; the complex was used differentially, i.e. depending on the identified pathology. In conclusion the article stated that individual treatment program with the obligatory inclusion of alarm-control for child with PNE should be selected after performing the recommended set of diagnostic measures

  8. [Factual approach to the treatment of genital herpes].

    Science.gov (United States)

    Nikkels, A F; Piérard, G E

    2000-05-01

    Genital herpes is a sexually transmitted disease. After the primary infection, the virus establishes a life-long latency in the sacral dorsal root ganglia. Recurrences may occur at an unpredictable rate. The clinical signs are not always easy to recognize and viral identification techniques may be helpful such as immunohistochemistry and in situ hybridization on Tzanck smears and muco-cutaneous biopsies. The treatment of genital herpes can follow one of three strategies using antiviral drugs, non-specific immunomodulators, and vaccination. The new oral antiviral drugs decrease the severity of clinical manifestations without, however, providing a definitive cure. In this article recent knowledge about the clinical aspects, differential diagnosis, diagnostic methods, treatment options and management is reviewed.

  9. Treatment for primary hypothyroidism: current approaches and future possibilities

    OpenAIRE

    Chakera, Ali J; Pearce, Simon HS; Vaidya, Bijay

    2011-01-01

    Ali J Chakera1, Simon HS Pearce2, Bijay Vaidya11Department of Endocrinology, Royal Devon and Exeter Hospital and Peninsula Medical School, Exeter, 2Endocrine Unit, Royal Victoria Infirmary and Newcastle University, Newcastle upon Tyne, UKAbstract: Primary hypothyroidism is the most common endocrine disease. Although the diagnosis and treatment of hypothyroidism is often considered simple, there are large numbers of people with this condition who are suboptimally treated. Even in those people ...

  10. Practical approaches to the treatment of severe pediatric obesity.

    Science.gov (United States)

    Lenders, C M; Gorman, K; Lim-Miller, A; Puklin, S; Pratt, J

    2011-12-01

    Pediatric obesity is a major public health threat. Obese children and adolescents are at increased risk for many medical and surgical conditions. These conditions may affect their quality of life and life expectancy. The rapidly progressive nature of type 2 diabetes mellitus within the first 5 years of obesity diagnosis is particularly concerning. Because health risk increases with degree of obesity, adolescents who may be eligible for more aggressive obesity treatment should be identified and counseled. Published by Elsevier Inc.

  11. An interprofessional approach to managing children with treatment-resistant enuresis: an educational review.

    Science.gov (United States)

    Caldwell, Patrina H Y; Lim, Melissa; Nankivell, Gail

    2017-11-06

    Enuresis (intermittent urinary incontinence during sleep in a child aged ≥ 5 years) is commonly seen in paediatric practice. Despite the availability of effective interventions, treatment resistance is encountered in up to 50% of children. In this educational review we attempt to provide insight into the causes of treatment resistance, and offer practical suggestions for addressing this condition using an interprofessional approach. We explore the pathophysiology of and standard treatments for enuresis and discuss why standard treatments may fail. An interprofessional approach to treatment resistance is proposed which utilises the expertise of professionals from different disciplines to address the problems and barriers to treatment. The two interprofessional approaches include a multidisciplinary approach that involves the patient being sent to experts in different disciplines at different times to address their treatment resistance utilising the skills of the respective experts, and an interdisciplinary approach that involves a patient being managed by members of interdisciplinary team who integrate their separate discipline perspectives into a single treatment plan. Although an interdisciplinary approach is ideal, interdisciplinary teams may not be available in all circumstances. Understanding the roles of other disciplines and engaging clinicians from other disciplines when appropriate can still be helpful when treatment resistance is encountered.

  12. Starvation Based Differential Chemotherapy: A Novel Approach for Cancer Treatment

    Directory of Open Access Journals (Sweden)

    Sidra Naveed

    2014-11-01

    Full Text Available Cancer patients undergoing chemotherapy treatment are advised to increase food intake to overcome the therapy-induced side effects, and weight loss. Dietary restriction is known to slow down the aging process and hence reduce age-related diseases such as cancer. Fasting or short-term starvation is more effective than dietary restriction to prevent cancer growth since starved cells switch off signals for growth and reproduction and enter a protective mode, while cancer cells, being mutated, are not sensitized by any external growth signals and are not protected against any stress. This phenomenon is known as differential stress resistance (DSR. Nutrient signaling pathways involving growth hormone/insulin-like growth factor-1 axis and its downstream effectors, play a key role in DSR in response to starvation controlling the other cell maintenance systems, such as autophagy and apoptosis, that are related to the tumorigenesis. Yeast cells lacking these effectors are better protected against oxidative stress compared to normal cells. In the same way, starvation protects many cell lines and mice against high-dose chemotherapeutic drugs. According to a series of studies, fasting results in overall reduction in chemotherapy side effects in cancer patients. Data shows that starvation-dependent differential chemotherapy is safe, feasible and effective in cancer treatment, but the possible side effects of starvation limit its efficacy. However, further studies and clinical trials may result in its implementation in cancer treatment.

  13. Potential approaches to the treatment of Ewing's sarcoma.

    Science.gov (United States)

    Yu, Hongjiu; Ge, Yonggui; Guo, Lianying; Huang, Lin

    2017-01-17

    Ewing's sarcoma (ES) is a highly aggressive and metastatic tumor in children and young adults caused by a chromosomal fusion between the Ewing sarcoma breakpoint region 1 (EWSR1) gene and the transcription factor FLI1 gene. ES is managed with standard treatments, including chemotherapy, surgery and radiation. Although the 5-year survival rate for primary ES has improved, the survival rate for ES patients with metastases or recurrence remains low. Several novel molecular targets in ES have recently been identified and investigated in preclinical and clinical settings, and targeting the function of receptor tyrosine kinases (RTKs), the fusion protein EWS-FLI1 and mTOR has shown promise. There has also been increasing interest in the immune responses of ES patients. Immunotherapies using T cells, NK cells, cancer vaccines and monoclonal antibodies have been considered for ES, especially for recurrent patients. Because understanding the pathogenesis of ES is extremely important for the development of novel treatments, this review focuses on the mechanisms and functions of targeted therapies and immunotherapies in ES. It is anticipated that integrating the knowledge obtained from basic research and translational and clinical studies will lead to the development of novel therapeutic strategies for the treatment of ES.

  14. Designing Psychological Treatments for Scalability: The PREMIUM Approach.

    Directory of Open Access Journals (Sweden)

    Sukumar Vellakkal

    Full Text Available Lack of access to empirically-supported psychological treatments (EPT that are contextually appropriate and feasible to deliver by non-specialist health workers (referred to as 'counsellors' are major barrier for the treatment of mental health problems in resource poor countries. To address this barrier, the 'Program for Effective Mental Health Interventions in Under-resourced Health Systems' (PREMIUM designed a method for the development of EPT for severe depression and harmful drinking. This was implemented over three years in India. This study assessed the relative usefulness and costs of the five 'steps' (Systematic reviews, In-depth interviews, Key informant surveys, Workshops with international experts, and Workshops with local experts in the first phase of identifying the strategies and theoretical model of the treatment and two 'steps' (Case series with specialists, and Case series and pilot trial with counsellors in the second phase of enhancing the acceptability and feasibility of its delivery by counsellors in PREMIUM with the aim of arriving at a parsimonious set of steps for future investigators to use for developing scalable EPT.The study used two sources of data: the usefulness ratings by the investigators and the resource utilization. The usefulness of each of the seven steps was assessed through the ratings by the investigators involved in the development of each of the two EPT, viz. Healthy Activity Program for severe depression and Counselling for Alcohol Problems for harmful drinking. Quantitative responses were elicited to rate the utility (usefulness/influence, followed by open-ended questions for explaining the rankings. The resources used by PREMIUM were computed in terms of time (months and monetary costs.The theoretical core of the new treatments were consistent with those of EPT derived from global evidence, viz. Behavioural Activation and Motivational Enhancement for severe depression and harmful drinking respectively

  15. Seagrass from Unified Florida Reef Tract Map (NODC Accession 0123059)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset is a subset of the Unified Map representing Seagrass areas. Version 1.1 - December 2013. The Unified Florida Reef Tract Map (Unified Reef Map) provides...

  16. [The comprehensive approach to the rehabilitative treatment of junior athletes].

    Science.gov (United States)

    Stepanenko, N P; Levitskaya, T E; Tsekhmeistruk, E A; Tren'kaeva, N A; Tyulyupo, S V; Dostovalova, O V; Kremeno, S V; Shakhova, S S; Chekcheeva, V D

    The objective of the present study was the development of the comprehensive program for the medico-psychological follow-up of the male and female junior athletes (rhythmic gymnastics) with the purpose of stabilizing their hormonal and emotional status, as well as improving sport performances based on the use of modern hardware-software technologies. The comprehensive examination of 72 female athletes at the mean age of 11.5±0.6 years attending R. Kuznetsov specialized school of rhythmic gymnastics of the Olympic reserve in the city of Seversk has been undertaken on the basis of Tomsk Research Institute of Balneology and Physiotherapy, the branch of Siberian Federal Research and Clinical Centre. The program of comprehensive medical psychological rehabilitation for the junior athletes of either sex engaged in sportive activities requiring precise technical actions has been elaborated. The method of the combined therapeutic treatment included physical exercises therapy, manual massage, dry carbonic bathtubs, psychological activities with the application of biological feedback trainings and cognitive trainings; it was intended for the correction of the hormonal status and the improvement of the psycho-emotional conditions of the athletes. The combined treatment based on the use of the modern hardware-software technologies was shown to promote the restoration and development of the psychophysical and psychological qualities of the male and female junior athletes indispensable for the maintenance of their high readiness for the efficient sports activities at the subsequent stages of the training cycle. In addition, such treatment enhances the adaptation resources of the athletes.

  17. Approach to and Treatment of Thyroid Disorders in the Elderly

    Science.gov (United States)

    Papaleontiou, Maria

    2012-01-01

    Synopsis Thyroid gland dysfunction is prevalent in older adults and may be associated with significant morbidity if misdiagnosed and left untreated. Due to a decreased number of symptoms at presentation, an increased susceptibility to adverse events if not treated, and a greater likelihood of harm from treatment, the diagnosis and management of thyroid disorders in older adults can be challenging. This review focuses on the epidemiology, clinical presentation, risks/complications, and management of thyroid disorders (including hyperthyroidism, hypothyroidism, thyroid nodules and thyroid cancer) in older adults. PMID:22443977

  18. Mini-Implants: New Possibilities in Interdisciplinary Treatment Approaches

    Directory of Open Access Journals (Sweden)

    Biju Sebastian

    2014-01-01

    Full Text Available The introduction of mini-implants has broadened the range of tooth movements possible by fixed appliance therapy alone. The limits of fixed orthodontic treatment have become more a matter of facial appearance than anchorage. Many complex cases which would previously have required surgery or functional appliances can now be treated with fixed appliance therapy using mini-implants. A mutilated dentition case where mini-implants were used to provide anchorage for intrusion of molars and retraction of anterior teeth is reported here to illustrate this point.

  19. Amelogenesis imperfecta and the treatment plan - interdisciplinary team approach.

    Science.gov (United States)

    Suchancova, B; Holly, D; Janska, M; Stebel, J; Lysy, J; Thurzo, A; Sasinek, S

    2014-01-01

    Amelogenesis imperfecta is a set of hereditary defects representing mainly the development defects of enamel without the presence of whole-body symptoms. Developmental disorders can manifest a complete absence of enamel, which is caused by improper differentiation of ameloblasts. This article describes the diagnosis and treatment of a patient with amelogenesis imperfecta, as well as the need for interdisciplinary cooperation to achieve the best possible morphological, skeletal, functional and aesthetic rehabilitation of the patients with this diagnosis. Furthermore, the article reviews literature dealing with other anomalies occurring in association with amelogenesis imperfect (Fig. 12, Ref. 20).

  20. Direct percutaneous transaortic approach for treatment of aortic pseudoaneurysms.

    Science.gov (United States)

    Pirelli, Luigi; Kliger, Chad; Fontana, Gregory P; Ruiz, Carlos E

    2015-05-01

    Aortic pseudoaneurysms (APAs) can develop months or years after aortic and cardiac surgery. If not treated appropriately, APAs can lead to fatal complications and ultimately death. We describe a case of a 61-year old patient with a diagnosed large pseudoaneurysm 5 years after his aortic valve surgery, who was treated with a novel transcatheter direct transaortic approach. The patient had dilated cardiomyopathy with an APA adjacent to the lower sternal plate. An Amplatzer septal occlusion device followed by coils was delivered transcutaneously through the APA to close its neck and fill the false aneurysm, respectively. Triple fusion multimodality imaging was used to guide the placement of the occlusion devices. The merging of computed tomography (CT) and echocardiography with real-time fluoroscopy was fundamental in procedural planning and guidance. Post-procedural transoesophageal echocardiogram (TOE) and CT angiography showed complete exclusion of the APA. A direct transaortic approach is a valid option for closure of an APA if the surgical risk is prohibitive, and the use of triple fusion technology is an essential tool in the hands of interventionalists and surgeons for preoperative planning and conduction of these procedures. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  1. A critical review on textile wastewater treatments: Possible approaches.

    Science.gov (United States)

    Holkar, Chandrakant R; Jadhav, Ananda J; Pinjari, Dipak V; Mahamuni, Naresh M; Pandit, Aniruddha B

    2016-11-01

    Waste water is a major environmental impediment for the growth of the textile industry besides the other minor issues like solid waste and resource waste management. Textile industry uses many kinds of synthetic dyes and discharge large amounts of highly colored wastewater as the uptake of these dyes by fabrics is very poor. This highly colored textile wastewater severely affects photosynthetic function in plant. It also has an impact on aquatic life due to low light penetration and oxygen consumption. It may also be lethal to certain forms of marine life due to the occurrence of component metals and chlorine present in the synthetic dyes. So, this textile wastewater must be treated before their discharge. In this article, different treatment methods to treat the textile wastewater have been presented along with cost per unit volume of treated water. Treatment methods discussed in this paper involve oxidation methods (cavitation, photocatalytic oxidation, ozone, H2O2, fentons process), physical methods (adsorption and filtration), biological methods (fungi, algae, bacteria, microbial fuel cell). This review article will also recommend the possible remedial measures to treat different types of effluent generated from each textile operation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Two Case Reports and Actual Treatment Approachs of Retroperitoneal Fibrosis

    Directory of Open Access Journals (Sweden)

    Eymen Gazel

    2013-06-01

    Full Text Available Retroperitoneal fibrosis (RPF is a rare disease of unclear etiology, which is characterized by a chronic non specific inflammation of the retroperitoneum. This inflammation of the retroperitoneum may entrap and obstruct retroperitoneal structures, particularly the ureters. Patients with RPF show non specific clinical symptoms, including poorly localized back pain, general malaise, weight loss, anemia, features of renal failure and occasionally, mild fever. The early symptoms are non specific and an accurate diagnosis is often achieved only subsequent to urological obstruction or the occurrence of renal failure. Although a number of scientific journals devoted to RPF are present in the litera¬ture, there is no accepted diagnostic or therapeutic strategy for this disease. However, there are several therapeutic strate¬gies which have been proven to be effective. Hereby, we reported two cases of retroperitoneal fibrosis which had similar symptoms and findings but different responses to medical treatment .We aimed to discuss challanges of RPF%u2019s diagnosis and the treatment protocol.

  3. An Integrative Approach to Treatment-Resistant Obsessive-Compulsive Disorder.

    Science.gov (United States)

    Woon, Luke Sy-Cherng; Kanapathy, Anita; Zakaria, Hazli; Alfonso, César A

    2017-01-01

    Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder that often runs a chronic unremitting course. Treatment outcomes can be unsatisfactory despite the availability of various somatic and psychological therapies. Psychodynamic psychotherapy in combination with cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) could help patients with treatment-resistant OCD achieve better outcomes. An integrative approach can help patients gain insight, strengthen the therapeutic alliance, improve treatment adherence, and provide symptomatic relief when other treatments seem insufficient or have failed. We describe the treatment process of a person with treatment-resistant OCD who received pharmacotherapy, concurrent CBT/ERP, and a brief course of psychodynamic psychotherapy. Case formulations from cognitive behavioral and psychodynamic perspectives are presented. The authors discuss the advantages of doing a psychodynamic assessment and formulation in treatment refractory cases and the wisdom of integrating psychotherapy interventions for OCD, as well as the unique clinical features of cases that warrant a multimodal treatment approach.

  4. The choice of surgical approach in the treatment of two-column acetabular fractures

    Directory of Open Access Journals (Sweden)

    A. A. Grin’

    2014-01-01

    Full Text Available The study aimed a comparison of treatment results in patients with two-column acetabular fractures (AO, Type C when using different operative approaches: ilioinguinal (12, Y-type (16 and a combination of posterior-lateral and ilioinguinal approaches (3. Surgical treatment was carried out not later than 3 weeks after injury. The joint congruence was reached in all the cases. The operative time, blood loss, complications, long-term results of treatment were evaluated. The study showed the effectiveness of ilioinguinal approach in case of the simple two-column fractures. When treating patients with complex fractures of the anterior column, the authors found no significant difference in operative time and intraoperative blood loss between the cases of V-type and combined approaches. In patients with two-column fractures accompanied with posterior wall lesion the time of surgery was significantly lower when using the Y-shaped approach as against the two different approaches.

  5. An innovative approach to the topical treatment of acne

    Directory of Open Access Journals (Sweden)

    Sparavigna A

    2015-04-01

    Full Text Available Adele Sparavigna, Beatrice Tenconi, Ileana De Ponti, Laura La PennaDermIng srl, Clinical Research and Bioengineering Institute, Monza, MB, ItalyAbstract: Acne is characterized by primary lesions on the face, chest, and back, and by a variety of other signs and symptoms. In particular, acne inflammatory lesions result from Propionibacterium acnes colonization and are of particular relevance as they can cause permanent scarring. Acne also causes significant psychological morbidity in affected patients. Products currently available for the treatment of acne include systemic and topical treatments. As these products can cause severe side effects, new, innovative therapies are needed. Farmaka Acne Cream (FAC is a novel, film-forming cream developed to treat mild and moderate acne. In vitro studies have demonstrated that FAC is as effective as 5% benzoyl peroxide in inhibiting growth of P. acnes. In 32 subjects with mild or moderate acne, FAC reduced all the major signs and symptoms of the disease. These included itching, erythema, and scaling, as well as reductions in the numbers of papules, pustules, and open and closed comedones. Acne severity improved in 38% of subjects, while none worsened. FAC was found to be effective in controlling sebum secretion, and was non-comedogenic. Most subjects (90% reported tolerability as good or very good, while clinical efficacy and cosmetic acceptability were judged as good. For assessment of contact sensitization and photosensitization, FAC was applied daily to the backs of 29 subjects in two symmetric areas for 10 days. Using a solar stimulator, one minimal erythema dose was delivered to one side of the back from days 11 to 13. The four different subareas of treated/untreated and irradiated/nonirradiated and combinations thereof were compared. No cases of contact sensitization or photosensitization were observed, and FAC is considered safe for use in intense sunlight. In vitro and in vivo studies provide

  6. Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach

    Directory of Open Access Journals (Sweden)

    Christopher Fagundes

    2015-08-01

    Full Text Available Being diagnosed and treated for breast cancer is emotionally and physically challenging. Breast cancer is the most commonly diagnosed cancer and the second leading cause of death for women in the United States. Accordingly, women with a breast cancer history are the largest group of female cancer survivors. Psychological stress substantially augments adverse autonomic, endocrine, and immune discharge, including enhanced production of proinflammatory cytokines. Importantly, inflammation is a key biological mechanism underlying the symptom cluster of pain, depression, fatigue, and sleep disturbances; there is also good evidence that inflammation contributes to breast cancer recurrence. Stress may exert direct effects on psychological and physiological risk processes. In this review, we take a biobehavioral approach to understanding predictors and mechanisms underlying somatic symptoms in breast cancer survivors.

  7. A multidisciplinary approach for the treatment of GIST liver metastasis

    Directory of Open Access Journals (Sweden)

    Paramo Juan C

    2008-05-01

    Full Text Available Abstract Background Advanced gastrointestinal stromal tumors (GISTs can metastasize and recur after a long remission period, resulting in serious morbidity, mortality, and complex management issues. Case presentation A 67-year-old woman presented with epigastric fullness, mild jaundice and weight loss with a history of a bowel resection 7 years prior for a primary GIST of the small bowel. The finding of a heterogeneous mass 15.5 cm in diameter replacing most of the left lobe of the liver by ultrasonography and CT, followed by positive cytological studies revealed a metastatic GIST. Perioperative optimization of the patient's nutritional status along with biliary drainage, and portal vein embolization were performed. Imatinib was successful in reducing the tumor size and facilitating surgical resection. Conclusion A well-planned multidisciplinary approach should be part of the standard management of advanced or metastatic GIST.

  8. A multidisciplinary approach for the treatment of GIST liver metastasis

    Science.gov (United States)

    Radkani, Pejman; Ghersi, Marcelo M; Paramo, Juan C; Mesko, Thomas W

    2008-01-01

    Background Advanced gastrointestinal stromal tumors (GISTs) can metastasize and recur after a long remission period, resulting in serious morbidity, mortality, and complex management issues. Case presentation A 67-year-old woman presented with epigastric fullness, mild jaundice and weight loss with a history of a bowel resection 7 years prior for a primary GIST of the small bowel. The finding of a heterogeneous mass 15.5 cm in diameter replacing most of the left lobe of the liver by ultrasonography and CT, followed by positive cytological studies revealed a metastatic GIST. Perioperative optimization of the patient's nutritional status along with biliary drainage, and portal vein embolization were performed. Imatinib was successful in reducing the tumor size and facilitating surgical resection. Conclusion A well-planned multidisciplinary approach should be part of the standard management of advanced or metastatic GIST. PMID:18471285

  9. Pretargeting immunotherapy: a novel treatment approach for systemic amyloidosis.

    Science.gov (United States)

    Wall, Jonathan S; Foster, James S; Martin, Emily B; Kennel, Stephen J

    2017-09-01

    The amyloidoses are a complex group of disorders characterized by the deposition of proteinaceous amyloid fibrils in vital organs. The deposits are nonimmunogenic and may be composed of one of more than 35 proteins. We have developed a two-stage immunotherapeutic approach using peptides that recognize most, if not all, amyloid deposits to facilitate amyloid clearance. In the first embodiment, we have developed a bifunctional peptope to enhance and expand the utility of currently available antibodies. In the second, we have generated peptide-reactive antibodies that can be targeted to the amyloid deposits by peptides thereby providing alternative reagents for immunotherapy of amyloidosis. These technologies provide tools for treating the many forms of amyloid disease, restoring organ function and enhancing patient survival.

  10. A sequential approach in treatment of perio-endo lesion.

    Science.gov (United States)

    Narang, Sumit; Narang, Anu; Gupta, Ruby

    2011-04-01

    The success of a combined periodontal and endodontic lesion depends on the elimination of both of these disease processes. In the case of a combined endo-perio lesion, the endodontic therapy results in healing of the endodontic component of involvement while the prognosis of tooth would finally depend on the healing of the periodontal structures. This case report evaluates the efficacy of bioactive glass in the management of furcation defect associated with an endo-perio lesion in a right mandibular first molar. A 22-year-old male patient with an endo-perio lesion in the right mandibular first molar was initially treated with endodontic therapy. Following the endodontic treatment, the furcation defect was treated using bioactive glass in a putty form. At the end of 9 months, there was a gain in the clinical attachment level and reduction in probing depth. Radiographic evidence showed that there was a significant bony fill.

  11. A sequential approach in treatment of perio-endo lesion

    Directory of Open Access Journals (Sweden)

    Sumit Narang

    2011-01-01

    Full Text Available The success of a combined periodontal and endodontic lesion depends on the elimination of both of these disease processes. In the case of a combined endo-perio lesion, the endodontic therapy results in healing of the endodontic component of involvement while the prognosis of tooth would finally depend on the healing of the periodontal structures. This case report evaluates the efficacy of bioactive glass in the management of furcation defect associated with an endo-perio lesion in a right mandibular first molar. A 22-year-old male patient with an endo-perio lesion in the right mandibular first molar was initially treated with endodontic therapy. Following the endodontic treatment, the furcation defect was treated using bioactive glass in a putty form. At the end of 9 months, there was a gain in the clinical attachment level and reduction in probing depth. Radiographic evidence showed that there was a significant bony fill.

  12. Chronic perineal pain: current pathophysiological aspects, diagnostic approaches and treatment.

    Science.gov (United States)

    Andromanakos, Nikolaos P; Kouraklis, Grigorios; Alkiviadis, Kostakis

    2011-01-01

    Chronic perineal pain is the anorectal and perineal pain without underlying organic disease, anorectal or endopelvic, which has been excluded by careful physical examination, radiological and endoscopic investigations. A variety of neuromuscular disorders of the pelvic floor lead to the different pathological conditions such as anorectal incontinence, urinary incontinence and constipation of obstructed defecation, sexual dysfunction and pain syndromes. The most common functional disorders of the pelvic floor muscles, accompanied by perineal pain are levator ani syndrome, proctalgia fugax, myofascial syndrome and coccygodynia. In the diagnosis of these syndromes, contributing to a thorough history, physical examination, selected specialized investigations and the exclusion of organic disease with proctalgia is carried out. Accurate diagnosis of the syndromes helps in choosing an appropriate treatment and in avoiding unnecessary and ineffective surgical procedures, which often are performed in an attempt to alleviate the patient's symptoms.

  13. Unified model of secondary electron cascades in diamond

    International Nuclear Information System (INIS)

    Ziaja, Beata; London, Richard A.; Hajdu, Janos

    2005-01-01

    In this article we present a detailed and unified theoretical treatment of secondary electron cascades that follow the absorption of x-ray photons. A Monte Carlo model has been constructed that treats in detail the evolution of electron cascades induced by photoelectrons and by Auger electrons following inner shell ionizations. Detailed calculations are presented for cascades initiated by electron energies between 0.1 and 10 keV. The present article expands our earlier work [B. Ziaja, D. van der Spoel, A. Szoeke, and J. Hajdu, Phys. Rev. B 64, 214104 (2001), Phys. Rev. B 66, 024116 (2002)] by extending the primary energy range, by improving the treatment of secondary electrons, especially at low electron energies, by including ionization by holes, and by taking into account their coupling to the crystal lattice. The calculations describe the three-dimensional evolution of the electron cloud, and monitor the equivalent instantaneous temperature of the free electron gas as the system cools. The dissipation of the impact energy proceeds predominantly through the production of secondary electrons whose energies are comparable to the binding energies of the valence (40-50 eV) and of the core electrons (300 eV). The electron cloud generated by a 10 keV electron is strongly anisotropic in the early phases of the cascade (t≤1 fs). At later times, the sample is dominated by low energy electrons, and these are scattered more isotropically by atoms in the sample. Our results for the total number of secondary electrons agree with available experimental data, and show that the emission of secondary electrons approaches saturation within about 100 fs following the primary impact

  14. Cancer Stem Cells – New Approach to Cancerogenensis and Treatment

    Directory of Open Access Journals (Sweden)

    Zuzana Mačingová

    2008-01-01

    Full Text Available Recently, there is an increasing evidence supporting the theory of cancer stem cells not only in leukemia but also in solid cancer. To date, the existence of cancer stem cells has been proven in acute and chronic myeloid leukemia, in breast cancer, in brain tumors, in lung cancer and gastrointestinal tumors. This review is focusing on the recent discovery of stem cells in leukemia, human brain tumors and breast cancer. A small population of cells in the tumor (less than 1 % shows the potential to give rise to the tumor and its growth. These cells have a substantial characteristic of stem cells – ability for self-renewal without loss of proliferation capacity with each cell division. Furthermore they are immortal, rather resistant to treatment and express typical markers of stem cells. The origin of these resident cancer stem cells is not clear. Whether the cancer stem cells originate from normal stem cells in consequence of genetic and epigenetic changes and/or redifferentiation from somatic tumor cells to the stem-like cells remains to be investigated. We propose the idea of the relation between normal tissue stem cells and cancer stem cells and their populations – progenitor cells. Based on this we highlight one of the major characteristic of stem cell – plasticity, which is equally important in the physiological regeneration process as well as carcinogenesis. Furthermore, we consider the microenvironment as a limiting factor for tumor genesis in AML, breast cancer and brain tumors. Thus the biological properties of cancer stem cells are just beginning to be revealed, the continuation of these studies should lead to the development of cancer stem cells target therapies for cancer treatment.

  15. Radiation therapy in the multimodal treatment approach of pituitary adenoma

    Energy Technology Data Exchange (ETDEWEB)

    Becker, G. [Klinik am Eichert, Goeppingen (Germany). Dept. of Radiooncology and Radiation Therapy; Radiooncologic Univ. Clinic, Tuebingen (Germany); Kocher, M.; Mueller, R.P. [Koeln Univ. (Germany). Clinic of Radiation Therapy; Kortmann, R.D.; Paulsen, F.; Jeremic, B.; Bamberg, M. [Radiooncologic Univ. Clinic, Tuebingen (Germany)

    2002-04-01

    In this paper, literature will be reviewed to assess the role of modern radiotherapy and radiosurgery in the management of pituitary adenomas. Material and Methods: Nowadays, magnetic resonance imaging for the definition of the target volume and a real three-dimensional (3-D) treatment planning with field conformation and the possibility for non-coplanar irradiation has to be recommended. Most groups irradiate these benign tumors with single doses of 1.8-2.0 Gy up to a total dose of 45 Gy or 50.4 Gy in extensive parasellar adenomas. Adenomas are mostly small, well circumscribed lesions, and have, therefore, attracted the use of stereotactically guided high-precision irradiation techniques which allow extreme focussing and provide steep dose gradients with selective treatment of the target and optimal protection of the surrounding brain tissue. Results: Radiation therapy controls tumor growth in 80-98% of patients with non-secreting adenomas and 67-89% for endocrine active tumors. Reviewing the recent literature including endocrine active and non-secreting adenomas, irradiated postoperatively or in case of recurrence the 5-, 10- and 15-year local control rates amount 92%, 89% and 79%. In cases of microprolactinoma primary therapy consists of dopamine agonists. Irradiation should be preferred in patients with macroprolactinomas, when drug therapy and/or surgery failed or for patients medically unsuitable for surgery. Reduction and control of prolactin secretion can be achieved in 44-70% of patients. After radiotherapy in acromegaly patients somatomedin-C and growth hormone concentrations decrease to normal levels in 70-90%, with a decrease rate of 10-30% per year. Hypercortisolism is controlled in 50-83% of adults and 80% of children with Cushing's disease, generally in less than 9 months. Hypopituitarism is the most common side effect of pituitary irradiation with an incidence of 13-56%. Long-term overall risk for brain necrosis in a total of 1,388 analyzed

  16. Radiation therapy in the multimodal treatment approach of pituitary adenoma

    International Nuclear Information System (INIS)

    Becker, G.; Kocher, M.; Mueller, R.P.

    2002-01-01

    In this paper, literature will be reviewed to assess the role of modern radiotherapy and radiosurgery in the management of pituitary adenomas. Material and Methods: Nowadays, magnetic resonance imaging for the definition of the target volume and a real three-dimensional (3-D) treatment planning with field conformation and the possibility for non-coplanar irradiation has to be recommended. Most groups irradiate these benign tumors with single doses of 1.8-2.0 Gy up to a total dose of 45 Gy or 50.4 Gy in extensive parasellar adenomas. Adenomas are mostly small, well circumscribed lesions, and have, therefore, attracted the use of stereotactically guided high-precision irradiation techniques which allow extreme focussing and provide steep dose gradients with selective treatment of the target and optimal protection of the surrounding brain tissue. Results: Radiation therapy controls tumor growth in 80-98% of patients with non-secreting adenomas and 67-89% for endocrine active tumors. Reviewing the recent literature including endocrine active and non-secreting adenomas, irradiated postoperatively or in case of recurrence the 5-, 10- and 15-year local control rates amount 92%, 89% and 79%. In cases of microprolactinoma primary therapy consists of dopamine agonists. Irradiation should be preferred in patients with macroprolactinomas, when drug therapy and/or surgery failed or for patients medically unsuitable for surgery. Reduction and control of prolactin secretion can be achieved in 44-70% of patients. After radiotherapy in acromegaly patients somatomedin-C and growth hormone concentrations decrease to normal levels in 70-90%, with a decrease rate of 10-30% per year. Hypercortisolism is controlled in 50-83% of adults and 80% of children with Cushing's disease, generally in less than 9 months. Hypopituitarism is the most common side effect of pituitary irradiation with an incidence of 13-56%. Long-term overall risk for brain necrosis in a total of 1,388 analyzed patients

  17. Quantitative safety goals for nuclear power plants: critical review and reformulation within a unified theory

    International Nuclear Information System (INIS)

    Munera, H.A.; Yadigaroglu, G.

    1988-01-01

    The first part of the paper critically reviews some of the adopted and/or proposed probabilistic safety goals and criteria in several countries. Some of the difficulties identified are:- Lack of an adequate delimitation of the scope of the non-deterministic choice problem. Consequently, the main components of the problem-probabilities and consequences-are not clearly defined. As a further consequence there is no unified treatment, including notation and terminology, for concepts like risk, probability, frequency, utility, risk-aversion, limit-line, etc. - The theoretical justifications and/or implications of limit-lines are not always fully understood. As a result three very different classes of limit-lines have emerged. The theoretical limitations of limit-lines are not always fully realized, leading to an over-emphasis in that approach and thus preventing the development of alternative methodologies. In the second part of the paper theoretical methods are indicated to compare probability distributions already existing in other disciplines, and a unified methodology to formulate probabilistic safety criteria is briefly described. The proposed theory gives due consideration to the whole probability distribution, and contains both limit-line concepts and global risk indices. The latter can easily incorporate regulatory and/or societal value-judgements, for instance risk-aversion. (author)

  18. A Product Line Enhanced Unified Process

    DEFF Research Database (Denmark)

    Zhang, Weishan; Kunz, Thomas

    2006-01-01

    The Unified Process facilitates reuse for a single system, but falls short handling multiple similar products. In this paper we present an enhanced Unified Process, called UPEPL, integrating the product line technology in order to alleviate this problem. In UPEPL, the product line related activit...... activities are added and could be conducted side by side with other classical UP activities. In this way both the advantages of Unified Process and software product lines could co-exist in UPEPL. We show how to use UPEPL with an industrial mobile device product line in our case study....

  19. A Unified Grand Tour of Theoretical Physics

    CERN Document Server

    Lawrie, Ian D

    2002-01-01

    A unified account of the principles of theoretical physics, A Unified Grand Tour of Theoretical Physics, Second Edition stresses the inter-relationships between areas that are usually treated as independent. The profound unifying influence of geometrical ideas, the powerful formal similarities between statistical mechanics and quantum field theory, and the ubiquitous role of symmetries in determining the essential structure of physical theories are emphasized throughout.This second edition conducts a grand tour of the fundamental theories that shape our modern understanding of the physical wor

  20. The unified theory of nuclear reactions

    International Nuclear Information System (INIS)

    Tobocman, W.

    A unified nuclear reaction theory is a formalism for the scattering reactions of many-body nuclear systems which is capable of describing both direct interaction and compound nucleus formation processes. The Feshbach projection operator formalism is the original unified nuclear reaction theory. An alternative unified nuclear reaction theory called the X-matrix formalism is described. The X-matrix formalism is a generalization of the Brown-de Dominicis formalism. It does not require projection operators and is readly applied to rearrangement collisions

  1. Biotechnological approaches to the treatment of aspermatogenic men

    Directory of Open Access Journals (Sweden)

    Pedro Manuel Aponte

    2013-01-01

    Full Text Available Aspermatogenesis is a severe impairment of spermatogenesis in which germ cells are completely lacking or present in an immature form, which results in sterility in approximately 25% of patients. Because assisted reproduction techniques require mature germ cells, biotechnology is a valuable tool for rescuing fertility while maintaining biological fatherhood. However, this process involves, for instance, the differentiation of preexisting immature germ cells or the production/derivation of sperm from somatic cells. This review critically addresses four potential techniques: sperm derivation in vitro, germ stem cell transplantation, xenologous systems, and haploidization. Sperm derivation in vitro is already feasible in fish and mammals through organ culture or 3D systems, and it is very useful in conditions of germ cell arrest or in type II Sertoli-cell-only syndrome. Patients afflicted by type I Sertoli-cell-only syndrome could also benefit from gamete derivation from induced pluripotent stem cells of somatic origin, and human haploid-like cells have already been obtained by using this novel methodology. In the absence of alternative strategies to generate sperm in vitro, in germ cells transplantation fertility is restored by placing donor cells in the recipient germ-cell-free seminiferous epithelium, which has proven effective in conditions of spermatogonial arrest. Grafting also provides an approach for ex-vivo generation of mature sperm, particularly using prepubertal testis tissue. Although less feasible, haploidization is an option for creating gametes based on biological cloning technology. In conclusion, the aforementioned promising techniques remain largely experimental and still require extensive research, which should address, among other concerns, ethical and biosafety issues, such as gamete epigenetic status, ploidy, and chromatin integrity.

  2. Snakebite in Australia: a practical approach to diagnosis and treatment.

    Science.gov (United States)

    Isbister, Geoffrey K; Brown, Simon G A; Page, Colin B; McCoubrie, David L; Greene, Shaun L; Buckley, Nicholas A

    2013-12-16

    Snakebite is a potential medical emergency and must receive high-priority assessment and treatment, even in patients who initially appear well. Patients should be treated in hospitals with onsite laboratory facilities, appropriate antivenom stocks and a clinician capable of treating complications such as anaphylaxis. All patients with suspected snakebite should be admitted to a suitable clinical unit, such as an emergency short-stay unit, for at least 12 hours after the bite. Serial blood testing (activated partial thromboplastin time, international normalised ratio and creatine kinase level) and neurological examinations should be done for all patients. Most snakebites will not result in significant envenoming and do not require antivenom. Antivenom should be administered as soon as there is evidence of envenoming. Evidence of systemic envenoming includes venom-induced consumption coagulopathy, sudden collapse, myotoxicity, neurotoxicity, thrombotic microangiopathy and renal impairment. Venomous snake groups each cause a characteristic clinical syndrome, which can be used in combination with local geographical distribution information to determine the probable snake involved and appropriate antivenom to use. The Snake Venom Detection Kit may assist in regions where the range of possible snakes is too broad to allow the use of monovalent antivenoms. When the snake identification remains unclear, two monovalent antivenoms (eg, brown snake and tiger snake antivenom) that cover possible snakes, or a polyvalent antivenom, can be used. One vial of the relevant antivenom is sufficient to bind all circulating venom. However, recovery may be delayed as many clinical and laboratory effects of venom are not immediately reversible. For expert advice on envenoming, contact the National Poisons Information Centre on 13 11 26.

  3. Treatment and disposal of tyres: Two EU approaches. A review.

    Science.gov (United States)

    Torretta, Vincenzo; Rada, Elena Cristina; Ragazzi, Marco; Trulli, Ettore; Istrate, Irina Aura; Cioca, Lucian Ionel

    2015-11-01

    The treatment and disposal of tyres from vehicles has long been of considerable environmental importance. The main problem lies in the mixed composition of the tyres. Studies have been undertaken to modify the structure of the tyres, especially with reference to the percentage of granulated rubber incorporated, in order to improve their performance, and also to reduce their environmental impact during normal functioning (noise, particulates, etc.) and facilitate recycling and final disposal. The aim of the present study is to review and compare how used tyres are treated and disposed of in two different EU countries. The first is Italy, which has been part of the European Union since its inception, and has important industrial traditions. The second is Romania, an emerging country which recently became part of the EU, and whose economic and industrial development has had a major boost in recent years, with a strong growth in waste production, together with consumption in urban areas. The occasion was useful to consider the situation concerning the evolution of the different aspects related to the management of the end-of-life tyres. In particular, the paper considers the properties of tyre waste and their potential reuse, the enhancement of end-of-life tires and the various types of recovery, such as the reconstruction of tyres and the material recovery. The aspects related to the energy recovery and the use of the life cycle analysis, as a tool to support the choices of the best management system, were also taken into consideration, not forgetting that an adequate end-of-life planning is important when developing a sustainable product, since it can affect considerably its overall life cycle. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. New Approaches in Detection and Treatment of Familial Hypercholesterolemia.

    Science.gov (United States)

    Hartgers, Merel L; Ray, Kausik K; Hovingh, G Kees

    2015-12-01

    Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder that clinically leads to increased low density lipoprotein-cholesterol (LDL-C) levels. As a consequence, FH patients are at high risk for cardiovascular disease (CVD). Mutations are found in genes coding for the LDLR, apoB, and PCSK9, although FH cannot be ruled out in the absence of a mutation in one of these genes. It is pivotal to diagnose FH at an early age, since lipid lowering results in a decreased risk of cardiovascular complications especially if initiated early, but unfortunately FH is largely underdiagnosed. While a number of clinical criteria are available, identification of a pathogenic mutation in any of the three aforementioned genes is seen by many as a way to establish a definitive diagnosis of FH. It should be remembered that clinical treatment is based on LDL-C levels and not solely on presence or absence of genetic mutations as LDL-C is what drives risk. Traditionally, mutation detection has been done by means of dideoxy sequencing. However, novel molecular testing methods are gradually being introduced. These next generation sequencing-based methods are likely to be applied on broader scale once their efficacy and effect on cost are being established. Statins are the first-line therapy of choice for FH patients as they have been proven to reduce CVD risk across a range of conditions including hypercholesterolemia (though not specifically tested in FH). However, in a significant proportion of FH patients LDL-C goals are not met, despite the use of maximal statin doses and additional lipid-lowering therapies. This underlines the need for additional therapies, and inhibition of PCSK9 and CETP is among the most promising new therapeutic options. In this review, we aim to provide an overview of the latest information about the definition, diagnosis, screening, and current and novel therapies for FH.

  5. Epidemiology and treatment approaches in management of invasive fungal infections

    Directory of Open Access Journals (Sweden)

    Kriengkauykiat J, Ito JI

    2011-05-01

    Full Text Available Jane Kriengkauykiat1,2, James I Ito2, Sanjeet S Dadwal21Department of Pharmacy, 2Division of Infectious Diseases, City of Hope, Duarte, CA, USAAbstract: Over the past 20 years, the number of invasive fungal infections has continued to persist, due primarily to the increased numbers of patients subjected to severe immunosuppression. Despite the development of more active, less toxic antifungal agents and the standard use of antifungal prophylaxis, invasive fungal infections (especially invasive mold infections continue to be a significant factor in hematopoietic cell and solid organ transplantation outcomes, resulting in high mortality rates. Since the use of fluconazole as standard prophylaxis in the hematopoietic cell transplantation setting, invasive candidiasis has come under control, but no mold-active antifungal agent (except for posaconazole in the setting of acute myelogenous leukemia and myelodysplastic syndrome has been shown to improve the survival rate over fluconazole. With the advent of new azole and echinocandin agents, we have seen the emergence of more azole-resistant and echinocandin-resistant fungi. The recent increase in zygomycosis seen in the hematopoietic cell transplantation setting may be due to the increased use of voriconazole. This has implications for the empiric approach to pulmonary invasive mold infections when zygomycosis cannot be ruled out. It is imperative that an amphotericin B product, an antifungal that has never developed resistance in over 50 years, be initiated. The clinical presentations of invasive mold infections and invasive candidiasis can be nonspecific and the diagnostic tests insensitive, so a high index of suspicion and immediate initiation of empiric therapy is required. Unfortunately, our currently available serologic tests do not predict infection ahead of disease, and, therefore cannot be used to initiate "preemptive" therapy. Also, the Aspergillus galactomannan test gives a false negative

  6. A unified tool for performance modelling and prediction

    International Nuclear Information System (INIS)

    Gilmore, Stephen; Kloul, Leila

    2005-01-01

    We describe a novel performability modelling approach, which facilitates the efficient solution of performance models extracted from high-level descriptions of systems. The notation which we use for our high-level designs is the Unified Modelling Language (UML) graphical modelling language. The technology which provides the efficient representation capability for the underlying performance model is the multi-terminal binary decision diagram (MTBDD)-based PRISM probabilistic model checker. The UML models are compiled through an intermediate language, the stochastic process algebra PEPA, before translation into MTBDDs for solution. We illustrate our approach on a real-world analysis problem from the domain of mobile telephony

  7. A unifying conceptual model of entrepreneurial management

    DEFF Research Database (Denmark)

    Senderovitz, Martin

    This article offers a systematic analysis and synthesis of the area of entrepreneurial management. Through a presentation of two main perspectives on entrepreneurial management and a newly developed unifying conceptual entrepreneurial management model, the paper discusses a number of theoretical...

  8. Unified data model for biological data

    International Nuclear Information System (INIS)

    Idrees, M.

    2014-01-01

    A data model empowers us to store, retrieve and manipulate data in a unified way. We consider the biological data consists of DNA (De-Oxyribonucleic Acid), RNA (Ribonucleic Acid) and protein structures. In our Bioinformatics Lab (Bioinformatics Lab, Alkhawarizmi Institute of Computer Science, University of Engineering and Technology, Lahore, Pakistan), we have already proposed two data models for DNA and protein structures individually. In this paper, we propose a unified data model by using the data models of TOS (Temporal Object Oriented System) after making some necessary modifications to this data model and our already proposed the two data models. This proposed unified data model can be used for the modeling and maintaining the biological data (i.e. DNA, RNA and protein structures), in a single unified way. (author)

  9. 76 FR 19893 - Unified Command Plan 2011

    Science.gov (United States)

    2011-04-08

    ... Plan 2011 Memorandum for the Secretary of Defense Pursuant to my authority as Commander in Chief, I hereby approve and direct the implementation of the revised Unified Command Plan. Consistent with title...

  10. Development of unified gauge theories: retrospect

    International Nuclear Information System (INIS)

    Lee, B.W.

    1977-01-01

    The construction and development of unified gauge theory of weak, electromagnetic, and strong interactions is reviewed. The Weinberg and Lee contributions to this study are mainly considered as personal recollections

  11. Unified universal quantum cloning machine and fidelities

    Energy Technology Data Exchange (ETDEWEB)

    Wang Yinan; Shi Handuo; Xiong Zhaoxi; Jing Li; Mu Liangzhu [School of Physics, Peking University, Beijing 100871 (China); Ren Xijun [School of Physics and Electronics, Henan University, Kaifeng 4750011 (China); Fan Heng [Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China)

    2011-09-15

    We present a unified universal quantum cloning machine, which combines several different existing universal cloning machines together, including the asymmetric case. In this unified framework, the identical pure states are projected equally into each copy initially constituted by input and one half of the maximally entangled states. We show explicitly that the output states of those universal cloning machines are the same. One importance of this unified cloning machine is that the cloning procession is always the symmetric projection, which reduces dramatically the difficulties for implementation. Also, it is found that this unified cloning machine can be directly modified to the general asymmetric case. Besides the global fidelity and the single-copy fidelity, we also present all possible arbitrary-copy fidelities.

  12. Unified Chiral models of mesons and baryons

    International Nuclear Information System (INIS)

    Mendez-Galain, R.; Ripka, G.

    1990-01-01

    Unified Chiral models of mesons and baryons are presented. Emphasis is placed on the underlying quark structure of hadrons including the Skyrmion. The Nambu Jona-Lasinio model with vector mesons is discussed

  13. Treatment of Sexual Disorders in the 1990s: An Integrated Approach.

    Science.gov (United States)

    Rosen, Raymond C.; Leiblum, Sandra R.

    1995-01-01

    Reviews existing data regarding the etiology and treatment of male and female sexual dysfunctions. Discusses the use of multidimensional assessment models, especially in the evaluation of erectile dysfunction and sexual pain disorders. Despite the conceptual and technological sophistication of current approaches, treatment outcomes are…

  14. Usefulness of a trauma-focused treatment approach for travel phobia

    NARCIS (Netherlands)

    de Jongh, A.; Holmshaw, M.; Carswell, W.; van Wijk, A.

    2011-01-01

    Despite its prevalence and potential impact on functioning, there are surprisingly little data regarding the treatment responsiveness of travel phobia. The purpose of this non-randomized study was to evaluate the usefulness of a trauma-focused treatment approach for travel phobia, or milder travel

  15. Water Supply Treatment Sustainability of Panching Water Supply Treatment Process - Water Footprint Approach

    Science.gov (United States)

    Aziz, Edriyana A.; Malek, Marlinda Abdul; Moni, Syazwan N.; Zulkifli, Nabil F.; Hadi, Iqmal H.

    2018-03-01

    In many parts of the world, freshwater is scarce and overexploited. The purpose of this study is to determine the water footprint of Water Supply Treatment Process (WSTP) at Panching Water Treatment Plant (WTP) as well as to identify the sustainability of the Sg. Kuantan as an intake resource due to the effect of land use development. The total water footprint (WF) will be calculated by using WF accounting manual. The results obtained shows that the water intake resource is still available but it is believed that it will not be able to cope with the increasing WF. The increment of water demand percentage by 1.8% from 2015 to 2016 has increased 11 times higher of the water footprint percentage, 19.9%. This result shows that the water consumption during the water supply treatment process is two times higher than the demand thus it shows the inefficient of the water management

  16. Can a surgery-first orthognathic approach reduce the total treatment time?

    Science.gov (United States)

    Jeong, Woo Shik; Choi, Jong Woo; Kim, Do Yeon; Lee, Jang Yeol; Kwon, Soon Man

    2017-04-01

    Although pre-surgical orthodontic treatment has been accepted as a necessary process for stable orthognathic correction in the traditional orthognathic approach, recent advances in the application of miniscrews and in the pre-surgical simulation of orthodontic management using dental models have shown that it is possible to perform a surgery-first orthognathic approach without pre-surgical orthodontic treatment. This prospective study investigated the surgical outcomes of patients with diagnosed skeletal class III dentofacial deformities who underwent orthognathic surgery between December 2007 and December 2014. Cephalometric landmark data for patients undergoing the surgery-first approach were analyzed in terms of postoperative changes in vertical and horizontal skeletal pattern, dental pattern, and soft tissue profile. Forty-five consecutive Asian patients with skeletal class III dentofacial deformities who underwent surgery-first orthognathic surgery and 52 patients who underwent conventional two-jaw orthognathic surgery were included. The analysis revealed that the total treatment period for the surgery-first approach averaged 14.6 months, compared with 22.0 months for the orthodontics-first approach. Comparisons between the immediate postoperative and preoperative and between the postoperative and immediate postoperative cephalometric data revealed factors that correlated with the total treatment duration. The surgery-first orthognathic approach can dramatically reduce the total treatment time, with no major complications. Copyright © 2016 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  17. Inverted Unified Power Quality Conditioner to compensate overvoltage

    Directory of Open Access Journals (Sweden)

    Yeison Alberto Garcés Gómez

    2017-07-01

    Full Text Available Introduction: The use of unified power quality conditioners UPQC in the electric systems can correct waveform distortions in a steady state, like harmonics, flicker, and the power factor. Objective: This paper presents a novel approach for active compensation of overvoltage with a UPQC in dual topology or iUPQC. Methodology: The study it is presented in five stages, the section I shows an introduction and the state of the art, section II presents the unified power quality conditioner UPQC, section III describes the generalized reactive power theory applied to the iUPQC (dual topology, section IV shows the numerical simulations and the results and section V presents the conclusions of the study. Results: The results for the application of the iUPQC to the compensation of overvoltage are proved and compared with the more representative theory related to compensation of harmonics and low power factor. Conclusions: The control algorithm presented for the unified power quality conditioner in dual topology allows to compensate the overvoltage in three-phase systems as well as voltage and current harmonics and the low power factor.

  18. Surgical treatment of traumatic cervical facet dislocation: anterior, posterior or combined approaches?

    Directory of Open Access Journals (Sweden)

    Catarina C. Lins

    Full Text Available ABSTRACT Surgical treatment is well accepted for patients with traumatic cervical facet joint dislocations (CFD, but there is uncertainty over which approach is better: anterior, posterior or combined. We performed a systematic literature review to evaluate the indications for anterior and posterior approaches in the management of CFD. Anterior approaches can restore cervical lordosis, and cause less postoperative pain and less wound problems. Posterior approaches are useful for direct reduction of locked facet joints and provide stronger fixation from a biomechanical point of view. Combined approaches can be used in more complex cases. Although both anterior and posterior approaches can be used interchangeably, there are some patients who may benefit from one of them over the other, as discussed in this review. Surgeons who treat cervical spine trauma should be able to perform both procedures as well as combined approaches to adequately manage CFD and improve patients’ final outcomes.

  19. A unified framework for the statistical characterization of the SNR of amplify-and-forward multihop channels

    KAUST Repository

    Yilmaz, Ferkan; Kucur, Oǧuz; Alouini, Mohamed-Slim

    2010-01-01

    In this paper, we present a unified approach to analyze the exact statistical characteristics of the harmonic mean of N ≥ 2 statistically independent and non-identically distributed random variables (RVs), which we term the N-normalized harmonic

  20. Decentralized approaches to wastewater treatment and management: applicability in developing countries.

    Science.gov (United States)

    Massoud, May A; Tarhini, Akram; Nasr, Joumana A

    2009-01-01

    Providing reliable and affordable wastewater treatment in rural areas is a challenge in many parts of the world, particularly in developing countries. The problems and limitations of the centralized approaches for wastewater treatment are progressively surfacing. Centralized wastewater collection and treatment systems are costly to build and operate, especially in areas with low population densities and dispersed households. Developing countries lack both the funding to construct centralized facilities and the technical expertise to manage and operate them. Alternatively, the decentralized approach for wastewater treatment which employs a combination of onsite and/or cluster systems is gaining more attention. Such an approach allows for flexibility in management, and simple as well as complex technologies are available. The decentralized system is not only a long-term solution for small communities but is more reliable and cost effective. This paper presents a review of the various decentralized approaches to wastewater treatment and management. A discussion as to their applicability in developing countries, primarily in rural areas, and challenges faced is emphasized all through the paper. While there are many impediments and challenges towards wastewater management in developing countries, these can be overcome by suitable planning and policy implementation. Understanding the receiving environment is crucial for technology selection and should be accomplished by conducting a comprehensive site evaluation process. Centralized management of the decentralized wastewater treatment systems is essential to ensure they are inspected and maintained regularly. Management strategies should be site specific accounting for social, cultural, environmental and economic conditions in the target area.

  1. Opioid Maintenance Treatment--A Call for a Joint European Quality Care Approach.

    Science.gov (United States)

    Brandt, Laura; Unger, Annemarie; Moser, Laura; Fischer, Gabriele; Jagsch, Reinhold

    2016-01-01

    The aim of this exploratory analysis of European Quality Audit of Opioid Treatment data was to identify areas of improvement for current opioid maintenance treatment (OMT) approaches. Factors facilitating treatment entry, retention and refusal were compared between 8 European countries and between OMT patient (OMT-P) and active opioid user (AOU) sample groups. Both groups were divided into those who had never had OMT before (un-experienced OMT-P (n = 573) and AOU (n = 360)) and those who had been maintained at least once prior to this investigation (experienced OMT-P (n = 746) and AOU (n = 377)). The European comparison showed that motives for starting OMT vary distinctly between countries (p ≤ 0.001). Transnationally, experienced AOU reported concerns about their ability to follow treatment rules and negative treatment experiences as decisive reasons for staying out of OMT. Greater flexibility, less pressure to reduce their treatment dose and greater treatment structure were ranked significantly higher by experienced compared to un-experienced OMT-P as factors that might facilitate treatment retention (p ≤ 0.05). Increasing awareness of potential shortcomings of OMT delivery systems is crucial to optimally match treatment approaches to patient needs and also to reduce the considerable economic burden of addiction to society. © 2015 S. Karger AG, Basel.

  2. Goal setting in psychotherapy: the relevance of approach and avoidance goals for treatment outcome.

    Science.gov (United States)

    Wollburg, Eileen; Braukhaus, Christoph

    2010-07-01

    The present study is the first aimed at investigating the influence of goal definition on treatment outcome in a sample of depressed patients. Data from 657 inpatients admitted to a psychosomatic clinic in Germany being treated in a cognitive-behavioral therapy program were analyzed. Treatment goals were identified as either approach or avoidance, and the sample was classified accordingly. Patients who identified approach goals only were placed in the approach group, and those who identified at least one avoidance goal were placed in the avoidance group. Results showed that framing goals using avoidance terms was associated with less symptomatic improvement but did not affect goal attainment. Findings from this research should be utilized in practice not only for process management such as individual treatment planning but also to control outcome quality. Furthermore, goal definition should be considered as a control variable in research on depression.

  3. A proposed clinical approach to chronic and "resistant" depressions: evaluation and treatment.

    Science.gov (United States)

    Akiskal, H S

    1985-10-01

    Many patients referred to specialized affective disorder units in the 1970s because of chronicity, treatment resistance, or treatment failure were found to have been inadequately treated--most typically with suboptimal trials of one to two tricyclic antidepressants (TCAs). In the 1980s, patients are being declared "treatment failures" following a more sophisticated range of treatment efforts. In part, the change can be attributed to systematic feedback provided by mood clinics to referring clinicians and to nationwide educational efforts. Terminologic and conceptual issues are reviewed, and chronicity and treatment failure in patients with affective disorders are examined from a multifactorial perspective involving pharmacokinetic factors, patient compliance, adequacy of somatic treatments, physician countertransference, social and interpersonal aspects, nosologic considerations, and medical-neurologic contributions. A systematic approach for evaluating and treating such patients is outlined.

  4. A geometrical foundation of a unified field theory

    International Nuclear Information System (INIS)

    Tauber, G.E.

    1983-01-01

    In a series of two little known papers Einstein and Mayer proposed a formalism by which they were able to obtain a theory of gravitation and electromagnetism similar to that of Kaluza and Klein. Instead of assuming, as these authors did, the existence of a five-dimensional continuum they assumed that at each point of space-time, regarded as a Riemannian space there exists a five-dimensional vector space. The purpose of this work is to generalize the approach of Einstein and Mayer to N dimensions and to lay the geometrical foundation of a possible unified field theory of gravitation with other fields. (Auth.)

  5. Toward a Unified Framework for Web Service Trustworthiness

    DEFF Research Database (Denmark)

    Miotto, N.; Dragoni, Nicola

    2012-01-01

    The intrinsic openness of the Service-Oriented Computing vision makes crucial to locate useful services and recognize them as trustworthy. What does it mean that a Web service is trustworthy? How can a software agent evaluate the trustworthiness of a Web service? In this paper we present an ongoing...... research aiming at providing an answer to these key issues to realize this vision. In particular, starting from an analysis of the weaknesses of current approaches, we discuss the possibility of a unified framework for Web service trustworthiness. The founding principle of our novel framework is that “hard...

  6. Unified time analysis of photon and particle tunnelling

    International Nuclear Information System (INIS)

    Olkhovsky, Vladislav S.; Recami, Erasmo; Jakiel, Jacek

    2001-07-01

    A unified approach to the time analysis of tunnelling of nonrelativistic particles is presented, in which Time is regarded as a quantum-mechanical observable, canonically conjugated to Energy. The validity of the Hartman effect (independence of the Tunnelling Time of the opaque barrier width, with superluminal group velocities as a consequence) is verified for all the known expressions of the mean tunnelling time. Moreover, the analogy between particle and photon tunnelling is suitably exploited. On the basic of such an analogy, an explanation of some recent microwave and optics experimental results on tunnelling time is proposed. Attention is devoted to some aspects of the causality problem for particle and photon tunnelling. (author)

  7. Novel approaches based on ultrasound for treatment of wastewater containing potassium ferrocyanide.

    Science.gov (United States)

    Jawale, Rajashree H; Tandale, Akash; Gogate, Parag R

    2017-09-01

    Industrial wastewaters containing biorefractory compounds like cyanide offer significant environmental problems attributed to the fact that the conventional methods have limited effectiveness and hence developing efficient treatment approaches is an important requirement. The present work investigates the use of novel treatment approach of ultrasound (US) combined with advanced oxidation techniques for the degradation of potassium ferrocyanide (KFC) for the first time. An ultrasonic bath equipped with longitudinal horn (1kW rated power and 25kHz frequency) has been used. The effect of initial pH (2-9) on the progress of degradation has been investigated initially and subsequently using the optimized pH, effect of addition of hydrogen peroxide (ratio of KFC:H 2 O 2 varied over the range of 1:0.5-1:5) and TiO 2 in the presence of H 2 O 2 (1:1 ratio by weight of TiO 2 ) as process intensifying approach has been studied. Combination of ultrasonic irradiation with ozone (O 3 ) (100-400mg/h) and ultraviolet irradiation (UV) has also been investigated. Use of combination of US with H 2 O 2, H 2 O 2 +TiO 2 and ozone resulted in extent of KFC degradation as 54.2%, 74.82% and 82.41% respectively. Combination of US with both UV and ozone was established to be the best approach yielding 92.47% degradation. The study also focused on establishing kinetic rate constants for all the treatment approaches which revealed that all the approaches followed first order kinetic mechanism with higher rate constants for the combination approaches. Overall, it has been conclusively established that ultrasound based combined treatment schemes are very effective for the treatment of KFC containing wastewaters. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Addressing anxiety in vivo in physiotherapy treatment of women with severe vaginismus: a clinical approach.

    Science.gov (United States)

    Rosenbaum, Talli

    2011-01-01

    Physiotherapy for the treatment of vaginismus is perceived as an intervention aimed to normalize muscle tone of the pelvic floor in order to allow vaginal penetration in accordance with the traditional view of vaginal spasm as its defining feature. Newer definitions recognize the experience of anxiety as well as pain, and effective treatment approaches should address these components as well. Physiotherapists often encounter women who, as a result of severe anxiety, are unable to undergo examination and treatment, despite their expressed desire to do so. This article describes a therapeutic intervention designed to help women with vaginismus prepare for examination and treatment by addressing the component of anxiety in real-life situations. This approach is also appropriate for nurse practitioners and physicians who work with this patient population and may be adapted for sex therapists to teach as a home exercise.

  9. The superior ophthalmic vein approach for the treatment of carotid-cavernous fistulas: our first experience

    Directory of Open Access Journals (Sweden)

    Chiriac A.

    2016-06-01

    Full Text Available Complex cavernous sinus fistulae (CCF are still a technical challenge to neurovascular team. The most commonly performed treatment consists in endovascular embolization of the lesion through an arterial or venous approach. Not always these conventional routes are feasible, requiring alternative routes. We report a case of a 44-year-old woman with a complex indirect (Barrow D carotid cavernous sinus fistula treated by two interventional sessions that imposing a retrograde direct transvenous approach via the superior ophthalmic vein.

  10. A Transdiagnostic Minority Stress Treatment Approach for Gay and Bisexual Men’s Syndemic Health Conditions

    Science.gov (United States)

    Pachankis, John E.

    2015-01-01

    Developing and deploying separate treatments for separate conditions seems ill-suited to intervening upon the co-occurring, and possibly functionally similar, psychosocial conditions facing gay and bisexual men. This article argues for the need to create transdiagnostic interventions that reduce multiple syndemic conditions facing gay and bisexual men at the level of their shared source in minority stress pathways. This article first reviews psychosocial syndemic conditions affecting gay and bisexual men, then suggests pathways that might link minority stress to psychosocial syndemics based on recent advancements in emotion science, psychiatric nosology, and cognitive-affective neuroscience, and finally suggests cross-cutting psychosocial treatment principles to reduce minority stress–syndemic pathways among gay and bisexual men. Because minority stress serves as a common basis of all psychosocial syndemic conditions reviewed here, locating the pathways through which minority stress generates psychosocial syndemics and employing overarching treatment principles capable of simultaneously alleviating these pathways will ultimately create a transdiagnostic approach to improving gay and bisexual men’s health. Clinical research and training approaches are suggested to further validate the pathways suggested here, establish the efficacy of treatment approaches tied to those pathways, and generate effective methods for disseminating a transdiagnostic minority stress treatment approach for gay and bisexual men’s psychosocial syndemic health. PMID:26123065

  11. Environmental Pollution, Toxicity Profile and Treatment Approaches for Tannery Wastewater and Its Chemical Pollutants.

    Science.gov (United States)

    Saxena, Gaurav; Chandra, Ram; Bharagava, Ram Naresh

    Leather industries are key contributors in the economy of many developing countries, but unfortunately they are facing serious challenges from the public and governments due to the associated environmental pollution. There is a public outcry against the industry due to the discharge of potentially toxic wastewater having alkaline pH, dark brown colour, unpleasant odour, high biological and chemical oxygen demand, total dissolved solids and a mixture of organic and inorganic pollutants. Various environment protection agencies have prioritized several chemicals as hazardous and restricted their use in leather processing however; many of these chemicals are used and discharged in wastewater. Therefore, it is imperative to adequately treat/detoxify the tannery wastewater for environmental safety. This paper provides a detail review on the environmental pollution and toxicity profile of tannery wastewater and chemicals. Furthermore, the status and advances in the existing treatment approaches used for the treatment and/or detoxification of tannery wastewater at both laboratory and pilot/industrial scale have been reviewed. In addition, the emerging treatment approaches alone or in combination with biological treatment approaches have also been considered. Moreover, the limitations of existing and emerging treatment approaches have been summarized and potential areas for further investigations have been discussed. In addition, the clean technologies for waste minimization, control and management are also discussed. Finally, the international legislation scenario on discharge limits for tannery wastewater and chemicals has also been discussed country wise with discharge standards for pollution prevention due to tannery wastewater.

  12. Finite element analysis of structures through unified formulation

    CERN Document Server

    Carrera, Erasmo; Petrolo, Marco; Zappino, Enrico

    2014-01-01

    The finite element method (FEM) is a computational tool widely used to design and analyse  complex structures. Currently, there are a number of different approaches to analysis using the FEM that vary according to the type of structure being analysed: beams and plates may use 1D or 2D approaches, shells and solids 2D or 3D approaches, and methods that work for one structure are typically not optimized to work for another. Finite Element Analysis of Structures Through Unified Formulation deals with the FEM used for the analysis of the mechanics of structures in the case of linear elasticity. The novelty of this book is that the finite elements (FEs) are formulated on the basis of a class of theories of structures known as the Carrera Unified Formulation (CUF). It formulates 1D, 2D and 3D FEs on the basis of the same ''fundamental nucleus'' that comes from geometrical relations and Hooke''s law, and presents both 1D and 2D refined FEs that only have displacement variables as in 3D elements. It also covers 1D...

  13. New unified fracture toughness estimation scheme for structural integrity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Wallin, K.; Nevasmaa, P. [VTT, Espoo (Finland); Bannister, A. [Research and Development, British Steel plc., Swinden Technology Centre Rotherham (United Kingdom)

    1998-12-31

    At present, treatment of fracture toughness data varies depending on the type of data (K{sub IC}, J, CTOD) that are available for fracture mechanics analysis. This complicates structural integrity assessment and makes it difficult to apply any single, unified procedure. Within the Brite-Euram project `SINTAP` a fracture toughness estimation scheme has been developed for the unified treatment of data for use in structural integrity assessment. As a procedure, it can be applied to Charpy data, as well as to fracture toughness data, and is suitable for the treatment of data at both single and different temperatures. The data sets may contain results from both homogeneous and inhomogeneous material, making the procedure applicable also to welded joints. The procedure allows fracture toughness assessment with quantified probability and confidence levels. Irrespective of the type of the original data, one material-specific K{sub mat} value representing a conservative estimate of the mean fracture toughness is obtained (with its probability distribution). This information can then be applied to structural integrity assessment. (orig.) 4 refs.

  14. New unified fracture toughness estimation scheme for structural integrity assessment

    Energy Technology Data Exchange (ETDEWEB)

    Wallin, K; Nevasmaa, P [VTT, Espoo (Finland); Bannister, A [Research and Development, British Steel plc., Swinden Technology Centre Rotherham (United Kingdom)

    1999-12-31

    At present, treatment of fracture toughness data varies depending on the type of data (K{sub IC}, J, CTOD) that are available for fracture mechanics analysis. This complicates structural integrity assessment and makes it difficult to apply any single, unified procedure. Within the Brite-Euram project `SINTAP` a fracture toughness estimation scheme has been developed for the unified treatment of data for use in structural integrity assessment. As a procedure, it can be applied to Charpy data, as well as to fracture toughness data, and is suitable for the treatment of data at both single and different temperatures. The data sets may contain results from both homogeneous and inhomogeneous material, making the procedure applicable also to welded joints. The procedure allows fracture toughness assessment with quantified probability and confidence levels. Irrespective of the type of the original data, one material-specific K{sub mat} value representing a conservative estimate of the mean fracture toughness is obtained (with its probability distribution). This information can then be applied to structural integrity assessment. (orig.) 4 refs.

  15. Unifying distribution functions: some lesser known distributions.

    Science.gov (United States)

    Moya-Cessa, J R; Moya-Cessa, H; Berriel-Valdos, L R; Aguilar-Loreto, O; Barberis-Blostein, P

    2008-08-01

    We show that there is a way to unify distribution functions that describe simultaneously a classical signal in space and (spatial) frequency and position and momentum for a quantum system. Probably the most well known of them is the Wigner distribution function. We show how to unify functions of the Cohen class, Rihaczek's complex energy function, and Husimi and Glauber-Sudarshan distribution functions. We do this by showing how they may be obtained from ordered forms of creation and annihilation operators and by obtaining them in terms of expectation values in different eigenbases.

  16. Technical writing practically unified through industry

    Science.gov (United States)

    Houston, L. S.

    1981-01-01

    General background details in the development of a university level technical writing program, based upon the writing tasks of the student's occupations, are summarized. Objectives and methods for unifying the courses of study with the needs of industry are discussed. Four academic course divisions, Industries Technologies, in which preparation and training are offered are: Animal, Horticulture, Agriculture, and Agricultural Business. Occupational competence is cited as the main goal for these programs in which technical writing is to be practically unified through industry. Course descriptions are also provided.

  17. Prospects of a Unified Management System

    DEFF Research Database (Denmark)

    Jørgensen, Tine Herreborg; Simonsen, Gorm

    2002-01-01

    In this article, the trend among management systems towards a common structure and the inclusion of additional areas of corporate concern (quality, environment, occupational health and safety and social responsibility) is outlined. The article suggests that a large part of the work associated...... with implementing and maintaining standardised management systems can be rationalised by developing a ?unified system?. The unified system is proposed to consist of a common basic standard of general managerial methodology expandable with supplements, which are related to the specific areas of concern...

  18. The feminist approach in the decision-making process for treatment of women with breast cancer.

    Science.gov (United States)

    Szumacher, Ewa

    2006-09-01

    The principal aim of this review was to investigate a feminist approach to the decision-making process for women with breast cancer. Empirical research into patient preferences for being informed about and participating in healthcare decisions has some limitations because it is mostly quantitative and designed within the dominant medical culture. Indigenous medical knowledge and alternative medical treatments are not widely accepted because of the lack of confirmed efficacy of such treatments in evidence-based literature. While discussing their treatment options with oncologists, women with breast cancer frequently express many concerns regarding treatment side effects, and sometimes decline conventional treatment when the risks are too high. A search of all relevant literary sources, including Pub-Med, ERIC, Medline, and the Ontario Institute for Studies in Education at the University of Toronto was conducted. The key words for selection of the articles were "feminism," "decision-making," "patients preferences for treatment," and "breast cancer." Fifty-one literary sources were selected. The review was divided into the following themes: (1) limitations of the patient decision-making process in conventional medicine; (2) participation of native North American patients in healthcare decisions; (3) towards a feminist approach to breast cancer; and (4) towards a feminist theory of breast cancer. This article discusses the importance of a feminist approach to the decision-making process for treatment of patients with breast cancer. As the literature suggests, the needs of minority patients are not completely fulfilled in Western medical culture. Introducing feminist theory into evidence-based medicine will help patients to be better informed about treatment choices and will assist them to select treatment according to their own beliefs and values.

  19. The effectiveness of the Minnesota Model approach in the treatment of adolescent drug abusers.

    Science.gov (United States)

    Winters, K C; Stinchfield, R D; Opland, E; Weller, C; Latimer, W W

    2000-04-01

    The treatment outcome of drug-abusing adolescents treated with a 12-Step approach. The study compares drug use outcome data at 6 and 12 months post-treatment among three groups of adolescents: those who completed treatment, those who did not and those on a waiting list. Also, among treatment completers, residential and outpatient samples were compared on outcome. The treatment site is located in the Minneapolis/St Paul area of Minnesota. Two hundred and forty-five drug clinic-referred adolescents (12-18 years old), all of whom met at least one DSM-III-R substance dependence disorder. One hundred and seventy-nine subjects received either complete or incomplete 12-Step, Minnesota Model treatment and 66 were waiting list subjects. In addition to demographics and clinical background variables, measures included treatment involvement, treatment setting and drug use frequency at intake and follow-up. Absolute and relative outcome analyses indicated that completing treatment was associated with far superior outcome compared to those who did not complete treatment or receive any at all. The percentage of treatment completers who reported either abstinence or a minor lapse for the 12 months following treatment was 53%, compared to 15 and 28% for the incompleter and waiting list groups, respectively. Favorable treatment outcome for drug abuse was about two to three times more likely if treatment was completed. Also, there were no outcome differences between residential and outpatient groups. Alcohol was the most common drug used during the follow-up period, despite cannabis being the preferred drug at intake.

  20. THE MODERN APPROACH OF CHILDREN’S TREATMENT WITH VELOPHARYNGEAL INSUFFICIENCY IN THE POSTOPERATIVE PERIOD

    Directory of Open Access Journals (Sweden)

    O. V. Nelyubina

    2014-01-01

    Full Text Available Velopharyngeal insufficiency is one of the main causes of speech disorders in children with congenital cleft palate, leading to social exclusion and disability of patients. This article describes an integrated approach to the treatment of velopharyngeal insufficiency, aimed in improving the anatomical and physiological function of velopharyngeal ring. Velopharyngeal ring is considered as the nervemuscle complex in the treatment of patients with this pathology. It is shown that a one-time complex treatment of velopharyngeal insufficiency, estimated with the program «Compare» in the below-described clinical example, increased velopharyngeal closure ring by 25%, thus eliminating nasality and significantly improve the quality of speech.

  1. Caries experience of Egyptian adolescents: does the atraumatic restorative treatment approach offer a solution?

    NARCIS (Netherlands)

    Mobarak, E.H.; Shabayek, M.M.; Mulder, J.; Reda, A.H.; Frencken, J.E.F.M.

    2011-01-01

    OBJECTIVES: To assess the prevalence and severity of dental caries amongst Egyptian adolescents and the prevalence of carious lesions treatable through the atraumatic restorative treatment (ART) approach. SUBJECTS AND METHODS: Using a convenient sample procedure, two secondary schools with a dental

  2. Melding Infant Mental Health and Multisystemic Therapy Approaches to Community-Based Treatment

    Science.gov (United States)

    Willoughby, Jay C.; Carubia, Beau A.; Murgolo, Marisa A.; Carter, Debbie R.; Frankel, Karen A.

    2013-01-01

    A recent partnership between the Irving Harris Program in Child Development and Infant Mental Health and the Community Based Psychiatry Program at University of Colorado Hospital joined two different approaches to child mental health treatment: infant mental health and multisystemic therapy (MST). This article illustrates the compatibility of…

  3. Adapting Evidence-Based Mental Health Treatments in Community Settings: Preliminary Results from a Partnership Approach

    Science.gov (United States)

    Southam-Gerow, Michael A.; Hourigan, Shannon E.; Allin, Robert B., Jr.

    2009-01-01

    This article describes the application of a university-community partnership model to the problem of adapting evidence-based treatment approaches in a community mental health setting. Background on partnership research is presented, with consideration of methodological and practical issues related to this kind of research. Then, a rationale for…

  4. Twenty-five-year atraumatic restorative treatment (ART) approach: a comprehensive overview

    NARCIS (Netherlands)

    Frencken, J.E.; Leal, S.C.; Navarro, M.F.

    2012-01-01

    BACKGROUND: The atraumatic restorative treatment (ART) approach was born 25 years ago in Tanzania. It has evolved into an essential caries management concept for improving quality and access to oral care globally. RESULTS: Meta-analyses and systematic reviews have indicated that the high

  5. Integrated and Holistic Treatment Approach to PTSD and SUD: A Synergy

    Science.gov (United States)

    Weis, Melanie

    2010-01-01

    Individuals living with posttraumatic stress disorder (PTSD) and addiction experience a complex and dynamic interaction of symptoms from both diagnoses. However, heretofore, each diagnosis has been approached as if it were a separate treatment consideration. Therefore, an individual may be treated for either a substance use disorder (SUD) or PTSD,…

  6. EVALUATION OF A TWO-STAGE PASSIVE TREATMENT APPROACH FOR MINING INFLUENCE WATERS

    Science.gov (United States)

    A two-stage passive treatment approach was assessed at bench-scale using two Colorado Mining Influenced Waters (MIWs). The first-stage was a limestone drain with the purpose of removing iron and aluminum and mitigating the potential effects of mineral acidity. The second stage w...

  7. The Social Marketing Approach: A Way to Increase Reporting and Treatment of Sexual Assault

    Science.gov (United States)

    Boehm, Amnon; Itzhaky, Haya

    2004-01-01

    Objective: Too often communities remain silent in response to cases of sexual assault of children. Members of the community are afraid to report such incidents and victims are reluctant to seek and accept treatment. The purpose of the paper is to examine whether application of a social marketing approach may serve as an effective means for…

  8. Innovative in situ treatment approach for DOE Savannah River Site Sanitary Landfill

    International Nuclear Information System (INIS)

    Knapp, J.; Suer, A.

    1994-01-01

    Pursuant to a settlement agreement reached between the US Department of Energy (DOE) and the South Carolina Department of Health and Environmental Control (SCDHEC), the Sanitary Landfill at the Savannah River Site will be closed. This paper addresses the approach used to select the innovative in situ treatment alternative for the groundwater and the vadose zone associated with the landfill

  9. Calcium phosphate granulation in anaerobic treatment of black water: a new approach to phosphorus recovery

    NARCIS (Netherlands)

    Tervahauta, T.H.; Weijden, van der R.D.; Flemming, R.L.; Hernández, L.; Zeeman, G.; Buisman, C.J.N.

    2014-01-01

    Recovery of phosphorus from wastewater as calcium phosphate could diminish the need for mining of scarce phosphate rock resources. This study introduces a novel approach to phosphorus recovery by precipitation of calcium phosphate granules in anaerobic treatment of black water. The granules formed

  10. Approach to treatment of a patient with burns from a radiological accident

    International Nuclear Information System (INIS)

    Roberto, Maria Angelica

    2009-01-01

    Lesions by exposure to ionizing radiation can result from an atomic bomb blast, an industrial accident such as Chernobyl, or from cancer therapy. The gravity of lesions depends on the exposure time and on the deposited energy. A short review is made on the approach to treatment in the Hospital Sao Jose, Lisbon. (author)

  11. Holistic Treatment Approaches to ADHD: Nutrition, Sleep,and Exercise, Part 7

    Science.gov (United States)

    Lavoie, Theresa

    2009-01-01

    This article is part of a series exploring Attention Deficit Hyperactivity Disorder (ADHD). In this seventh installment, the author discusses three holistic treatments for children and adults with ADHD: diet and nutrition, sleep, and exercise. These approaches focus and improve the overall health of ADHD patients. (For Part 6 of this series, see…

  12. [New anterolateral approach of distal femur for treatment of distal femoral fractures].

    Science.gov (United States)

    Zhang, Bin; Dai, Min; Zou, Fan; Luo, Song; Li, Binhua; Qiu, Ping; Nie, Tao

    2013-11-01

    To assess the effectiveness of the new anterolateral approach of the distal femur for the treatment of distal femoral fractures. Between July 2007 and December 2009, 58 patients with distal femoral fractures were treated by new anterolateral approach of the distal femur in 28 patients (new approach group) and by conventional approach in 30 patients (conventional approach group). There was no significant difference in gender, age, cause of injury, affected side, type of fracture, disease duration, complication, or preoperative intervention (P > 0.05). The operation time, intraoperative blood loss, intraoperative fluoroscopy frequency, hospitalization days, and Hospital for Special Surgery (HSS) score of knee were recorded. Operation was successfully completed in all patients of 2 groups, and healing of incision by first intention was obtained; no vascular and nerves injuries occurred. The operation time and intraoperative fluoroscopy frequency of new approach group were significantly less than those of conventional approach group (P 0.05). All patients were followed up 12-36 months (mean, 19.8 months). Bone union was shown on X-ray films; the fracture healing time was (12.62 +/- 2.34) weeks in the new approach group and was (13.78 +/- 1.94) weeks in the conventional approach group, showing no significant difference (t=2.78, P=0.10). The knee HSS score at last follow-up was 94.4 +/- 4.2 in the new approach group, and was 89.2 +/- 6.0 in the conventional approach group, showing significant difference between 2 groups (t=3.85, P=0.00). New anterolateral approach of the distal femur for distal femoral fractures has the advantages of exposure plenitude, minimal tissue trauma, and early function rehabilitation training so as to enhance the function recovery of knee joint.

  13. Laboratory evaluation of the in situ chemical treatment approach to soil and groundwater remediation

    International Nuclear Information System (INIS)

    Thorton, E.C.; Trader, D.E.

    1993-10-01

    Results of initial proof of principle laboratory testing activities successfully demonstrated the viability of the in situ chemical treatment approach for remediation of soil and groundwater contaminated by hexavalent chromium. Testing activities currently in progress further indicate that soils contaminated with hexavalent chromium and uranium at concentrations of several hundred parts per million can be successfully treated with 100 ppM hydrogen sulfide gas mixtures. Greater than 90% immobilization of hexavalent chromium and 50% immobilization of uranium have been achieved in these tests after a treatment period of one day. Activities associated with further development and implementation of the in situ chemical treatment approach include conducting additional bench scale tests with contaminated geomedia, and undertaking scale-up laboratory tests and a field demonstration. This report discusses the testing and further development of this process

  14. The unified coordination language UnCL.

    NARCIS (Netherlands)

    F.S. de Boer (Frank); J.V. Guillen Scholten (Juan); J.F. Jacob (Joost)

    2005-01-01

    textabstractIn this paper we show how to use a (subset) of UML as an Unified Coordination Language (UnCL) that is based on a separation of concerns between coordination and computation. As such UnCL provides a general language for the coordination of, in particular, object-oriented applications. The

  15. A Unified Introduction to Ordinary Differential Equations

    Science.gov (United States)

    Lutzer, Carl V.

    2006-01-01

    This article describes how a presentation from the point of view of differential operators can be used to (partially) unify the myriad techniques in an introductory course in ordinary differential equations by providing students with a powerful, flexible paradigm that extends into (or from) linear algebra. (Contains 1 footnote.)

  16. Unifying Learning Object Repositories in MACE

    NARCIS (Netherlands)

    Prause, Christian; Ternier, Stefaan; De Jong, Tim; Apelt, Stefan; Scholten, Marius; Wolpers, Martin; Eisenhauer, Markus; Vandeputte, Bram; Specht, Marcus; Duval, Erik

    2007-01-01

    Prause, C., Ternier, S., De Jong, T., Apelt, S., Scholten, M., Wolpers, M., et al. (2007). Unifying Learning Object Repositories in MACE. In D. Massart, J.-N. Colin & F. V. Assche (Eds.). Proceedings of the First International Workshop on Learning Object Discovery & Exchange (LODE'07). September,

  17. Unify a hazardous materials/waste program

    International Nuclear Information System (INIS)

    Carson, H.T.

    1988-01-01

    Efficiently managing a hazardous materials/waste program in a multi-facility, multi-product corporation is a major challenge. This paper describes several methods to help unify a program and gain maximum efficiency of manpower and to minimize risk

  18. A unified theory in higher dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kapetanakis, D. (National Research Centre for the Physical Sciences Democritos, Athens (Greece)); Zoupanos, G. (European Organization for Nuclear Research, Geneva (Switzerland))

    1990-10-11

    We present a grand unified model defined in ten dimensions and based on the group SO(13). The model is dimensionally reduced over the non-simply-connected space (Su(3)/U(1)xU(1))/Z{sub 2} giving in four dimensions the standard model. (orig.).

  19. A unified theory in higher dimensions

    International Nuclear Information System (INIS)

    Kapetanakis, D.; Zoupanos, G.

    1990-01-01

    We present a grand unified model defined in ten dimensions and based on the group SO(13). The model is dimensionally reduced over the non-simply-connected space [Su(3)/U(1)xU(1)]/Z 2 giving in four dimensions the standard model. (orig.)

  20. Toward a Unified Theory of Human Reasoning.

    Science.gov (United States)

    Sternberg, Robert J.

    1986-01-01

    The goal of this unified theory of human reasoning is to specify what constitutes reasoning and to characterize the psychological distinction between inductive and deductive reasoning. The theory views reasoning as the controlled and mediated application of three processes (encoding, comparison and selective combination) to inferential rules. (JAZ)

  1. IDEA: A Unifying Theory for Evaluation Systems

    DEFF Research Database (Denmark)

    Bella, Giampaolo; Giustolisi, Rosario

    2017-01-01

    Secure systems for voting, exams, auctions and conference paper management are theorised to address the same problem, that of secure evaluations. In support of such a unifying theory comes a model for Secure Evaluation Systems (SES), which offers innovative common grounds to understand all four...

  2. Modified Risdon approach using periangular incision in surgical treatment of subcondylar mandibular fractures

    Directory of Open Access Journals (Sweden)

    Nikolić Živorad S.

    2016-01-01

    Full Text Available Introduction. No consensus has been reached yet on the surgical approach for treatment of condylar fractures. Objective. The aim of this study was to present modified Risdon approach (without facial nerve identification in the treatment of subcondylar mandibular fractures. Method. This is a retrospective study of a period 2005-2012. During this seven-year period, 25 condylar mandibular fractures in 22 men and three women (19-68 years old were treated by modified Risdon approach without identifying the facial nerve. The main inclusion criterion was subcondylar fracture according to Lindahl classification. Results. No additional morbidity related to postoperative complications, such as infection or salivary fistula, was observed in this series. Only two (8% patients developed temporary weakness of the marginal branch of the facial nerve, which resolved six weeks postoperatively. Each patient achieved good mouth opening postoperatively. Scar was camouflaged in the first cervical wrinkle. Two patients developed temporomandibular joint dysfunction. No patient had postoperative occlusal disturbance. In all of the patients good aesthetic result was achieved in a two-year follow-up. Conclusion. In comparison with techniques described in the literature, the main advantages of the modified Risdon approach are the following: no need for facial vessels identification; direct, fast, and safe approach to mandibular angle and subcondylar region; relatively simple surgical technique and good cosmetic result - due to aesthetically placed incision. This approach could be recommended for subcondylar fracture as a simplified and safe procedure. [Projekat Ministarstva nauke Republike Srbije, br. 175075

  3. Comparison of various approaches for the treatment of fractures of the mandibular condylar process.

    Science.gov (United States)

    Handschel, Jörg; Rüggeberg, Tim; Depprich, Rita; Schwarz, Frank; Meyer, Ulrich; Kübler, Norbert R; Naujoks, Christian

    2012-12-01

    Fractures of the mandibular condyle process are the most common fractures of the lower jaw. Unfortunately, the type of treatment is still a matter of debate. The aim of this investigation was to compare the outcome of different treatment approaches regarding function and surgical side-effects. 111 fractures of the mandibular condyle representing all types according to the classification of Spiessl and Schroll were included. Both closed reduction (CR) and open reduction with internal fixation (ORIF) including the retromandibular/transparotid, submandibular, preauricular and intraoral approach were performed. The clinical examination included functional and aesthetic aspects at least 1 year after the fracture. The majority of fractures (45%) were classified into Type II and IV according to Spiessl and Schroll followed by fractures without any displacement or dislocation (29.7%). The submandibular approach showed the worst outcome regarding permanent palsy of the facial nerve and hypertrophic scarring. No significant differences between the various approaches were detected in the functional status in any diagnosis group. Inferior condylar neck fractures benefit from ORIF by an intraoral approach whereas in high condylar neck fractures the retromandibular/transparotid approach shows the best results. Fractures of the condylar head were almost all treated by CR and our results cannot contribute to the debate of CR vs. ORIF in this type of fracture. Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  4. Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

    International Nuclear Information System (INIS)

    Scorsetti, Marta; Navarria, Pierina; Pessina, Federico; Ascolese, Anna Maria; D’Agostino, Giuseppe; Tomatis, Stefano; De Rose, Fiorenza; Villa, Elisa; Maggi, Giulia; Simonelli, Matteo; Clerici, Elena; Soffietti, Riccardo; Santoro, Armando; Cozzi, Luca; Bello, Lorenzo

    2015-01-01

    Long-term local control in Glioblastoma is rarely achieved and nearly all patients relapse. In this study we evaluated the clinical effect of different treatment approaches in recurrent patients. Forty-three patients, with median age of 51 years were evaluated for salvage treatment: re-resection and/or re-irradiation plus chemotherapy or chemotherapy alone. Response was recorded using the Response Assessment in Neuro-Oncology criteria. Hematologic and non-hematologic toxicities were graded according to Common Terminology Criteria for Adverse Events 4.0. Twenty-one patients underwent chemotherapy combined with local treatment, surgery and/or radiation therapy, and 22 underwent chemotherapy only. The median follow up was 7 months (range 3–28 months). The 1 and 2-years Progression Free Survival was 65 and 10 % for combined treatment and 22 and 0 % for chemotherapy alone (p < 0.01). The 1 and 2-years overall survival was 69 and 29 % for combined and 26 and 0 % for chemotherapy alone (p < 0.01). No toxicity greater than grade 2 was recorded. These data showed that in glioblastoma recurrence the combination of several approaches in a limited group of patients is more effective than a single treatment alone. This stress the importance of multimodality treatment whenever clinically feasible

  5. Treatment decision-making among Canadian youth with severe haemophilia: a qualitative approach.

    Science.gov (United States)

    Lane, S J; Walker, I; Chan, A K; Heddle, N M; Poon, M-C; Minuk, L; Jardine, L; Arnold, E; Sholapur, N; Webert, K E

    2015-03-01

    The first generation of young men using primary prophylaxis is coming of age. Important questions regarding the management of severe haemophilia with prophylaxis persist: Can prophylaxis be stopped? At what age? To what effect? Can the regimen be individualized? The reasons why some individuals discontinue or poorly comply with prophylaxis are not well understood. These issues have been explored using predominantly quantitative research approaches, yielding little insight into treatment decision-making from the perspectives of persons with haemophilia (PWH). Positioning the PWH as a source of expertise about their condition and its management, we undertook a qualitative study: (i) to explore and understand the lived experience of young men with severe haemophilia A or B and (ii) to identify the factors and inter-relationships between factors that affect young men's treatment decision-making. This manuscript reports primarily on the second objective. A modified Straussian, grounded theory methodology was used for data collection (interviews) and preliminary analysis. The study sample, youth aged 15-29, with severe haemophilia A or B, was chosen selectively and recruited through three Canadian Haemophilia Treatment Centres. We found treatment decision-making to be multi-factorial and used the Framework method to analyze the inter-relationships between factors. A typology of four distinct approaches to treatment was identified: lifestyle routine prophylaxis, situational prophylaxis, strict routine prophylaxis and no prophylaxis. Standardized treatment definitions (i.e.: 'primary' and 'secondary', 'prophylaxis') do not adequately describe the ways participants treat. Naming the variation of approaches documented in this study can improve PWH/provider communication, treatment planning and education. © 2014 John Wiley & Sons Ltd.

  6. Radial and Regge excitations in unified, grand unified and subconstituent models

    International Nuclear Information System (INIS)

    Schnitzer, H.J.

    1981-01-01

    Necessary group theoretic conditions for all elementary gauge bosons and fermions of an arbitrary renormalizable gauge theory to lie on Regge trajectories are reviewed. It is then argued that in properly unified gauge theories all particles of a given spin lie on Regge trajectories. This then implies that a properly unified gauge theory has no local U(1) factor groups, and no massive fermion singlets. A consideration of the general pattern of Regge and radial recurrences to be expected in quantum field theories suggests that the presence or absence of spin 3/2 quarks and/or leptons in the TeV region will provide crucial clues to enable one to distinguish between various classes of unified, grand unified, and subconstituent models. The correct interpretation of such excited fermions will require correlation with the higgs boson mass and possible radial and Regge excitations of the weak vector bosons. (orig.)

  7. MBR technology: a promising approach for the (pre-)treatment of hospital wastewater.

    Science.gov (United States)

    Beier, S; Cramer, C; Mauer, C; Köster, S; Schröder, H Fr; Pinnekamp, J

    2012-01-01

    Membrane bioreactor (MBR) technology is a very reliable and extensively tested solution for biological wastewater treatment. Nowadays, separate treatment of highly polluted wastewater streams especially from hospitals and other health care facilities is currently under investigation worldwide. In this context, the MBR technology will play a decisive role because an effluent widely cleaned up from solids and nutrients is absolutely mandatory for a subsequent further elimination of organic trace pollutants. Taking hospital wastewater as an example, the aim of this study was to investigate to what extent MBR technology is an adequate 'pre-treatment' solution for further elimination of trace pollutants. Therefore, we investigated - within a 2-year period - the performance of a full-scale hospital wastewater treatment plant (WWTP) equipped with a MBR by referring to conventional chemical and microbiological standard parameters. Furthermore, we measured the energy consumption and tested different operating conditions. According to our findings the MBR treatment of the hospital wastewater was highly efficient in terms of the removal of solids and nutrients. Finally, we did not observe any major adverse effects on the operation and performance of the MBR system which potentially could derive from the composition of the hospital wastewater. In total, the present study proved that MBR technology is a very efficient and reliable treatment approach for the treatment of highly polluted wastewater from hospitals and can be recommended as a suitable pre-treatment solution for further trace pollutant removal.

  8. designing a framework for a unified electronic identity system

    African Journals Online (AJOL)

    DJFLEX

    In this paper, a Unified Identity System is proposed where single electronic identity (eID) is issued that can be used ... online commerce and public sector organizations. Because ..... SearchUnifiedCommunications.com Definitions, Access date.

  9. Comparison of three different surgical approaches for treatment of thoracolumbar burst fracture

    Directory of Open Access Journals (Sweden)

    WU Han

    2013-02-01

    Full Text Available 【Abstract】Objective: The main treatment method used for thoracolumbar fractures is open reduction and in-ternal fixation. Commonly there are three surgical approaches: anterior, posterior and paraspinal. We attempt to compare the three approaches based on our clinical data analysis. Methods: A group of 94 patients with Denis type A or B thoracolumbar burst fracture between March 2008 and September 2010 were recruited in this study. These patients were treated by anterior-, posterior- or paraspinal-approach reduction with or without decompression. The fracture was fixed with titanium mesh and Z-plate via anterior approach (24 patients, screw and rod system via posterior approach (38 patients or paraspinal approach (32 patients. Clinical evaluations included operation duration, blood loss, inci-sion length, preoperative and postoperative Oswestry dis-ability index (ODI. Results: The average operation duration (94.1 min±13.7 min, blood loss (86.7 ml±20.0 ml, length of incision (9.3 mm± 0.7 mm and postoperative ODI (6±0.5 were signifi-cantly lower (P<0.05 in paraspinal approach group than in traditional posterior approach group (operation duration 94.1 min±13.7 min, blood loss 143.3 ml±28.3 ml, length of incision 15.4 cm±2.1 cm and ODI 12±0.7 and anterior approach group (operation duration 176.3 min±20.7 min, blood loss 255.1 ml±38.4 ml, length of incision 18.6 cm±2.4 cm and ODI 13±2.4. There was not statistical difference in terms of Cobb angle on radiographs among the three approaches. Conclusion: The anterior approach surgery is conve-nient for resection of the vertebrae and reconstruction of vertebral height, but it is more complicated and traumatic. Hence it is mostly used for severe Denis type B fracture. The posterior approach is commonly applied to most thora-columbar fractures and has fewer complications compared with the anterior approach, but it has some shortcomings as well. The paraspinal approach has great advantages

  10. Learning, epigenetics, and computation: An extension on Fitch's proposal. Comment on “Toward a computational framework for cognitive biology: Unifying approaches from cognitive neuroscience and comparative cognition” by W. Tecumseh Fitch

    Science.gov (United States)

    Okanoya, Kazuo

    2014-09-01

    The comparative computational approach of Fitch [1] attempts to renew the classical David Marr paradigm of computation, algorithm, and implementation, by introducing evolutionary view of the relationship between neural architecture and cognition. This comparative evolutionary view provides constraints useful in narrowing down the problem space for both cognition and neural mechanisms. I will provide two examples from our own studies that reinforce and extend Fitch's proposal.

  11. Subcranial approach in the surgical treatment of anterior skull base trauma.

    Science.gov (United States)

    Schaller, B

    2005-04-01

    Fractures of the anterior skull base, because of the region's anatomical relationships, are readily complicated by neurological damage to the brain or cranial nerves. This review highlights the use of a subcranial approach in the operative treatment of injuries of the anterior skull base and compares it to the more traditional neurosurgical transcranial approach. The extended anterior subcranial approach takes advantage of the specific features of injuries in this region and allows direct access to the central anterior cranial base in order to repair fractures, close CSF fistulae and relieve of optic nerve compression. It avoids extensive frontal lobe manipulation. The success of the approach in achieving the aims of surgery with low morbidity is reviewed.

  12. Principles and approaches to the treatment of immune-mediated movement disorders.

    Science.gov (United States)

    Mohammad, Shekeeb S; Dale, Russell C

    2018-03-01

    Immune mediated movement disorders include movement disorders in the context of autoimmune encephalitis such as anti-NMDAR encephalitis, post-infectious autoimmune movement disorders such as Sydenham chorea, paraneoplastic autoimmune movement disorders such as opsoclonus myoclonus ataxia syndrome, and infection triggered conditions such as paediatric acute neuropsychiatric syndrome. This review focuses on the approach to treatment of immune mediated movement disorders, which requires an understanding of the immunopathogenesis, whether the disease is destructive or 'altering', and the natural history of disease. Factors that can influence outcome include the severity of disease, the delay before starting therapy, use of multimodal therapy and whether the course is monophasic or relapsing. Although the four main conditions listed above have different pathophysiological processes, there are general themes that broadly apply including: early diagnosis and treatment is better, minimise the severity of disease, escalate treatment if the patient is not responding to initial treatments, and minimise relapse. Copyright © 2017. Published by Elsevier Ltd.

  13. Treatment of Aphasia Combining Neuromodulation and Behavioral Intervention: Taking an Impairment and Functional Approach

    Directory of Open Access Journals (Sweden)

    Elizabeth E. Galletta

    2014-04-01

    Baseline measures of naming nouns and verbs in single words, and sentences, were obtained. While there was no improvement in production of nouns or verbs in single words or sentence production after sham tDCS, and no improvement of noun production after anodal tDCS and speech-language treatment, production of verbs in sentences improved after a 10-session treatment block of anodal tDCS and behavioral therapy. Conclusion Administering a behavioral treatment that is impairment-based as well as functionally-based in conjunction with tDCS is both feasible and promising. Anodal tDCS in conjunction with behavioral intervention is a treatment approach that warrants continued investigation. The results will be discussed in relation to the tDCS and aphasia literature.

  14. Host-Directed Therapeutics as a Novel Approach for Tuberculosis Treatment.

    Science.gov (United States)

    Kim, Ye-Ram; Yang, Chul-Su

    2017-09-28

    Despite significant efforts to improve the treatment of tuberculosis (TB), it remains a prevalent infectious disease worldwide owing to the limitations of current TB therapeutic regimens. Recent work on novel TB treatment strategies has suggested that directly targeting host factors may be beneficial for TB treatment. Such strategies, termed host-directed therapeutics (HDTs), focus on host-pathogen interactions. HDTs may be more effective than the currently approved TB drugs, which are limited by the long durations of treatment needed and the emergence of drug-resistant strains. Targets of HDTs include host factors such as cytokines, immune checkpoints, immune cell functions, and essential enzyme activities. This review article discusses examples of potentially promising HDTs and introduces novel approaches for their development.

  15. Dependence of patients' life quality on severity of oral pathology: optimization of treatment approaches

    Directory of Open Access Journals (Sweden)

    Ivanova S.V.

    2011-03-01

    Full Text Available The research goals include: 1 assessment the quality of life of those patients who have defects of tooth rows not replaced by orthopedic appliances on the basis of the complex analysis; 2 choice of more reasonable method of treatment. The use of dental questionnaires such as Oral Health Impact Profile-14 (OHIP-14 while treating oral pathology allows both optimizing an approach to choosing an appropriate treatment method and making more successful prognosis as to the efficiency of treatment being performed. The quality of life of those patients who have tooth rows defects not replaced by orthopedic appliances depends on sex, age, family status, employment and extent of tooth rows defects. Patients with tooth rows defects not replaced by orthopedic appliances accompanied by diseases of peri-odontium are characterized by worse quality of life. This fact must be taken into consideration while planning patients' treatment

  16. Unified commutation-pruning technique for efficient computation of composite DFTs

    Science.gov (United States)

    Castro-Palazuelos, David E.; Medina-Melendrez, Modesto Gpe.; Torres-Roman, Deni L.; Shkvarko, Yuriy V.

    2015-12-01

    An efficient computation of a composite length discrete Fourier transform (DFT), as well as a fast Fourier transform (FFT) of both time and space data sequences in uncertain (non-sparse or sparse) computational scenarios, requires specific processing algorithms. Traditional algorithms typically employ some pruning methods without any commutations, which prevents them from attaining the potential computational efficiency. In this paper, we propose an alternative unified approach with automatic commutations between three computational modalities aimed at efficient computations of the pruned DFTs adapted for variable composite lengths of the non-sparse input-output data. The first modality is an implementation of the direct computation of a composite length DFT, the second one employs the second-order recursive filtering method, and the third one performs the new pruned decomposed transform. The pruned decomposed transform algorithm performs the decimation in time or space (DIT) data acquisition domain and, then, decimation in frequency (DIF). The unified combination of these three algorithms is addressed as the DFTCOMM technique. Based on the treatment of the combinational-type hypotheses testing optimization problem of preferable allocations between all feasible commuting-pruning modalities, we have found the global optimal solution to the pruning problem that always requires a fewer or, at most, the same number of arithmetic operations than other feasible modalities. The DFTCOMM method outperforms the existing competing pruning techniques in the sense of attainable savings in the number of required arithmetic operations. It requires fewer or at most the same number of arithmetic operations for its execution than any other of the competing pruning methods reported in the literature. Finally, we provide the comparison of the DFTCOMM with the recently developed sparse fast Fourier transform (SFFT) algorithmic family. We feature that, in the sensing scenarios with

  17. Dynamic Cognitive Tracing: Towards Unified Discovery of Student and Cognitive Models

    Science.gov (United States)

    Gonzalez-Brenes, Jose P.; Mostow, Jack

    2012-01-01

    This work describes a unified approach to two problems previously addressed separately in Intelligent Tutoring Systems: (i) Cognitive Modeling, which factorizes problem solving steps into the latent set of skills required to perform them; and (ii) Student Modeling, which infers students' learning by observing student performance. The practical…

  18. Metrics for aggregating the climate effects of different emissions: a unifying framework

    NARCIS (Netherlands)

    Tol, R.S.J.; Berntsen, T.K.; O'Neill, B.C.; Fuglestvedt, J.S.; Shine, K.P.

    2012-01-01

    Multi-gas approaches to climate change policies require a metric establishing equivalences among emissions of various species. Climate scientists and economists have proposed four kinds of such metrics and debated their relative merits. We present a unifying framework that clarifies the

  19. Causal fermion systems as a candidate for a unified physical theory

    International Nuclear Information System (INIS)

    Finster, Felix; Kleiner, Johannes

    2015-01-01

    The theory of causal fermion systems is an approach to describe fundamental physics. Giving quantum mechanics, general relativity and quantum field theory as limiting cases, it is a candidate for a unified physical theory. We here give a non-technical introduction. (paper)

  20. Causal fermion systems as a candidate for a unified physical theory

    Science.gov (United States)

    Finster, Felix; Kleiner, Johannes

    2015-07-01

    The theory of causal fermion systems is an approach to describe fundamental physics. Giving quantum mechanics, general relativity and quantum field theory as limiting cases, it is a candidate for a unified physical theory. We here give a non-technical introduction.